category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	78/2701	142/9376	1.90677422550855	MID1/UBE2E2/CBLB/UBC/UBE2H/ANAPC16/UBE2R2/UBE2L6/ANAPC5/HERC1/UBE2G1/UBE2G2/ELOC/UBA6/UBE2N/UBE2B/NEDD4/UBA2/CUL1/UBE2Z/WWP2/UBE2Q2/CDC27/CUL4A/SMURF1/STUB1/HUWE1/TRIP12/UBE2J1/UBE2Q1/UBE2D2/HERC4/UBR5/PRKN/FBXW11/FBXW7/UBE3C/PML/UBE2D3/UBE2E1/UBE2K/UBE2W/MAP3K1/CDC26/CUL3/ANAPC7/MGRN1/SAE1/UBE4A/UBA1/CUL5/SOCS3/FBXW8/RHOBTB1/PIAS1/TRAF6/SMURF2/ITCH/NEDD4L/MDM2/CBL/FANCL/HERC2/CUL4B/BIRC3/KLHL13/CDC16/TRIM37/UBE4B/BIRC6/ANAPC4/DDB2/ANAPC1/FZR1/PIAS3/VHL/BRCA1/UBOX5	6.92581201461857
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	98/2701	205/9376	1.65945404141194	CDKN1A/HLA-DRB1/HLA-B/HLA-A/HLA-F/AKT3/RELB/HLA-E/HLA-C/JAK1/CCND3/HLA-DPA1/HLA-DPB1/HLA-DRB5/MYC/IKBKB/STAT3/TAPBP/HLA-DQB1/PIK3CB/TBK1/SNW1/SIN3A/TNFAIP3/TAP1/PIK3R3/GADD45A/NFKBIA/HLA-DMA/NEDD4/STAT1/PSMD13/PLCG2/CD40/POLK/RELA/HES1/HLA-DRA/NFKBIB/IRF3/TAP2/BCL2/CYCS/HDAC1/RIPK1/PSMD11/TRAF3/SEM1/PSMC5/MAP3K14/PSMD2/PSMC3/PSMD14/BCL2L11/IFNAR1/E2F3/PSMD7/NFKB2/EIF2AK2/HLA-DQA1/MAP2K3/NCOR2/OAS1/HLA-DQA2/MAPK8/IRAK4/ISG15/MAP2K4/TRAF6/TRAF5/MDM2/SAP30L/HLA-DOA/SAP30/GADD45B/CASP3/IRF7/OAS2/RAC1/NFKBIE/DDB2/IL6/TAPBPL/MAPK12/TRAF2/VIM/AKT2/MAPK11/GADD45G/ICAM1/MAP2K7/TYK2/ENTPD1/CCNE2/MAP2K6/CD3E/HLA-DQB2/RUNX3	6.07261031893384
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	104/2701	224/9376	1.61167821441794	TGFBR2/CREB5/CDKN1A/NFATC1/ETS1/HLA-DRB1/HLA-B/HLA-A/HLA-F/AKT3/FOSL1/ETS2/RELB/HLA-E/HLA-C/JAK1/CCND3/HLA-DPA1/PPP3CA/HLA-DPB1/HLA-DRB5/MYC/IKBKB/PPP3CC/HLA-DQB1/TGFB2/SMAD3/IL15/PIK3CB/ANAPC16/NFATC2/FDPS/ZFP36/ADCY4/ANAPC5/DLG1/MAPK3/PIK3R3/NFKBIA/HLA-DMA/KAT2B/ELK4/CDKN2C/CD40/RELA/SMAD2/CRTC3/CDC27/HLA-DRA/STAT5B/MAP3K3/IL1R1/TLN1/TNFRSF1A/STAT5A/RAN/GPS2/MAPK1/SMAD4/IL15RA/MAP3K14/TBPL1/ATF2/MAP3K1/CREB1/CDC26/LTBR/E2F3/NFKB2/HLA-DQA1/ANAPC7/HLA-DQA2/POLB/PPP3CB/ATR/MAP2K1/MAPK8/HRAS/BUB3/MAP2K4/CREBBP/ATF6B/HLA-DOA/EP300/CDC16/CREB3L2/TRRAP/ANAPC4/ANAPC1/IL6/AKT2/ELK1/ADCY6/KAT2A/ICAM1/RANBP3/TGFB3/KAT5/TBP/CCNE2/LCK/CD3E/HLA-DQB2/ADCY1	5.89401601579519
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	113/2701	250/9376	1.5690307293595	TGFBR2/ASAP1/CBLB/HLA-B/HLA-A/HLA-F/PARD6G/EHD2/DNM3/RAB11A/HLA-E/HLA-C/EEA1/HSPA1A/HSPA1B/RAB11FIP5/CHMP3/PRKCZ/ARPC5L/LDLR/HSPA8/CHMP4B/PARD3/SMAD3/ARFGAP3/EHD4/AP2B1/ARAP3/SPART/HSPA6/VPS37B/GRK5/ARFGEF2/ASAP2/ZFYVE9/SH3GL1/NEDD4/RAB11FIP1/PIP5K1A/RAB11FIP3/SMAD2/EHD1/CHMP4A/SMURF1/AGAP3/GBF1/RAB22A/RUFY1/SNX1/ARRB1/VPS26A/IGF2R/CLTB/PML/AP2A1/ARF5/RAB11B/CYTH2/TSG101/VPS36/PDCD6IP/GIT1/RUFY2/RAB8A/RAB7A/RAB5A/CHMP2A/ARFGEF1/ARAP2/CHMP2B/IQSEC1/RABEP1/EGFR/SPG21/USP8/VPS4A/RAB35/HRAS/EPS15/DNM2/EPN2/TRAF6/AGAP1/SMURF2/PRKCI/WIPF2/ITCH/ASAP3/PIP5K1C/NEDD4L/MDM2/CBL/HGS/ZFYVE27/SNX12/STAMBP/CYTH1/VPS37C/PLD2/CLTCL1/ARFGAP1/IGF1R/WASHC2A/AGAP9/CXCR4/WIPF3/CHMP4C/HSPA1L/IQSEC3/ACAP1/ACTR3B/IQSEC2/ACTR3C	5.80079860423331
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	82/2701	169/9376	1.68430276754829	AKT3/MAP1LC3A/OPTN/CAMKK2/DAPK1/UBC/SQSTM1/RRAS2/GABARAPL1/DAPK3/CALCOCO2/DAPK2/VMP1/PIK3CB/PRKAA2/HIF1A/TBK1/MAPK3/MAP1LC3B/ERN1/PIK3R3/BECN1/EIF2S1/UVRAG/ATG101/BCL2/GABARAPL2/RB1CC1/WDR45B/ATG2B/MAPK1/VPS39/ATG4B/PPP2CA/ULK1/RPS6KB1/RAB8A/STX17/RAB7A/DDIT4/RRAGC/IGBP1/ATG5/PRKAA1/RPTOR/MAP2K1/MAPK8/PPP2CB/PIK3C3/ATG12/HRAS/MTMR3/MTOR/TRAF6/RUBCN/CFLAR/PLEKHM1/BNIP3/ZFYVE1/WDR45/WDR41/PRKCQ/AMBRA1/BIRC6/EIF2AK3/PIK3R4/ATG13/MRAS/ULK2/RRAGB/MTMR4/DEPTOR/AKT2/GORASP1/TP53INP2/ATG9A/IGF1R/IRS2/AKT1S1/ATG4A/YKT6/RAB7B	5.71024671243828
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	110/2701	248/9376	1.53969258697496	RHOJ/TUBB6/ANXA2/AHNAK/AKT3/MYL9/TCF7L1/S100A10/FLNA/CASP4/TXN/MYC/IKBKB/WASF3/DYNC1I2/ARPC5L/TUBB4B/HSP90AB1/TNFRSF10B/KLC1/PIK3CB/DYNC1H1/MLKL/DYNC1LI2/DCTN2/NOD1/TUBA1A/MAPK3/TCF7L2/HSP90AA1/MYO6/PIK3C2A/MYL12A/NCKAP1/NFKBIA/DYNC1I1/ROCK2/RELA/KPNA4/DCTN3/PAK3/DYNC1LI1/DYNLT1/BCL2/KPNA1/DYNC2H1/CYCS/TNFRSF1A/RIPK1/MAPK1/PLEKHM2/BRK1/GSDMD/GAPDH/DYNLL1/CYTH2/CASP7/VPS39/DYNLT3/RAB7A/MAP2K3/ACBD3/RAB5A/TUBA1C/EXOC4/TNFRSF10A/RALA/DCTN1/ACTR1A/MAP2K1/MAPK8/KPNA3/AHNAK2/IRAK4/PIK3C3/HRAS/DNM2/MAP2K4/TRAF6/PLEKHM1/TUBA4A/STX10/ACTR1B/DYNC2LI1/BIRC3/RIPK2/CASP3/RAC1/RILP/MYL12B/CYTH1/ACTG1/IL6/MAPK12/TRAF2/AKT2/MAPK11/FYCO1/SNX33/MAP2K7/ELMO1/DYNLRB2/LEF1/ACTR3B/TUBB3/KLC2/ACTR3C/MAP2K6/RAB9B/RAB7B	5.47906903873778
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	51/2701	93/9376	1.90361992571449	ACTN1/TGFBR2/INSR/MYL9/TCF7L1/NECTIN3/RAP1B/WASF3/CTNNA1/PARD3/SMAD3/YES1/FGFR1/PTPRM/MAPK3/TCF7L2/RASIP1/SORBS1/MYL12A/ROCK2/NECTIN2/SMURF1/IQGAP1/CSNK2B/MAPK1/FER/SMAD4/PTPN1/ROCK1/WASF1/CSNK2A1/EGFR/VCL/MET/SMURF2/CSNK2A2/FYN/RAP1A/CREBBP/BAIAP2/SNAI1/EP300/NLK/RAC1/MYL12B/ACTG1/SNAI2/IGF1R/PTPRF/LEF1/HEG1	5.57064384824517
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	110/2701	253/9376	1.50926387972249	ACTN1/FOXO1/PLCE1/AKT3/MYL9/CAPNS1/FNBP1L/CAST/MAP1LC3A/CAPN2/CASP4/SEPTIN6/BCAR1/UBC/SQSTM1/DOCK1/IKBKB/PXN/DIAPH1/ARPC5L/CALCOCO2/CTTN/PRKCE/PIK3CB/BCL10/PLCB4/HK1/NOD1/ITGA5/SEPTIN9/TBK1/MAPK3/CBX3/MAP1LC3B/MYL12A/PIK3R3/UBE2N/NFKBIA/RBCK1/BECN1/CUL1/ROCK2/PLCG2/RELA/IL1R1/TLN1/NFKBIB/UBE2D2/IRF3/BCL2/CYCS/MALT1/FBXW11/TNFRSF1A/RIPK1/MAPK1/UBE2D3/ILK/CYTH2/ROCK1/RPS6KB1/WASF1/TNIP1/RRAGC/PTK2/ATG5/EGFR/VCL/RPTOR/MAPK8/ITPR3/PIK3C3/ATG12/GSK3A/GSK3B/SEPTIN11/MTOR/TRAF6/SEPTIN8/TRAF5/BNIP3/MDM2/C3/PLCG1/CGAS/PRKCQ/RIPK2/RAC1/PIK3R4/MYL12B/CYTH1/ACTG1/GLMN/ITGB1/FOXO3/RRAGB/MAPK12/TRAF2/AKT2/MAPK11/PLCB1/ELMO1/AKT1S1/U2AF1L4/ACTR3B/HK2/PLCD4/RNF31/ACTR3C/PLCD1	5.22343978673124
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	57/2701	112/9376	1.76664727349659	HLA-DRB1/AKT3/LAMA4/JAK1/HLA-DPA1/LAMA3/LAMB1/HLA-DPB1/HSPA1A/HLA-DRB5/HSPA1B/IKBKB/STAT3/LDLR/HSPA8/HLA-DQB1/TGFB2/ITGA6/HSPA6/MAPK3/NFKBIA/HLA-DMA/STAT1/CD40/RELA/HLA-DRA/NFKBIB/BCL2/LAMB2/CYCS/TNFRSF1A/MAPK1/GNAI3/CIITA/HLA-DQA1/MAP2K3/HLA-DQA2/MAPK8/IRAK4/TRAF6/HLA-DOA/BIRC3/CASP3/LAMC1/ITGB1/MAPK12/AKT2/MAPK11/TGFB3/PPIF/TYK2/HSPA1L/IFNG/MAP2K6/GNAO1/HLA-DQB2/JAK2	5.19191565938945
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	91/2701	203/9376	1.55610310357594	ACTN1/RELN/SHC1/FLT4/VWF/EMP1/TNXB/THBS1/AKT3/MYL9/LAMA4/EMP2/CAPN2/ITGA9/ITGB4/PDGFD/FLNA/CCND3/BCAR1/FLNB/LAMA3/LAMB1/VAV3/RAP1B/DOCK1/TNC/PXN/DIAPH1/ITGA1/PARVA/ITGAV/PIK3CB/PDGFA/ITGA6/ITGA5/MAPK3/ZYX/PARVB/MYL12A/PIK3R3/ITGB3/ROCK2/PIP5K1A/PPP1R12B/BRAF/TLN1/PAK3/PAK2/VEGFA/BCL2/LAMB2/PPP1R12C/MAPK1/ILK/PGF/ROCK1/PTK2/COL4A5/EGFR/VCL/MAP2K1/MAPK8/ITGA8/VEGFC/MET/SOS2/HRAS/GSK3B/THBS3/FYN/RAP1A/PIP5K1C/BIRC3/ARHGAP35/RAC1/ITGA10/LAMC1/MYL12B/THBS2/PDGFB/ACTG1/ITGB1/AKT2/ELK1/COL6A3/IGF1R/ITGB8/FLT1/ITGA11/SHC2/ITGA7	5.09530207589301
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	84/2701	184/9376	1.58472707370861	SEMA3A/SEMA3D/SEMA6A/EFNA5/SSH1/MYL9/PARD6G/LIMK2/PPP3CA/PRKCZ/PPP3CC/PARD3/EPHB1/DPYSL2/PIK3CB/EPHB4/NFATC2/PTPN11/MAPK3/BOC/ABLIM1/RND1/MYL12A/PIK3R3/CAMK2D/ROCK2/UNC5A/PLCG2/NCK1/EFNA1/SRGAP1/ABLIM3/PAK3/ABLIM2/PAK2/NTN1/SEMA4A/RYK/SRGAP2/MAPK1/ILK/GNAI3/NTN4/CFL2/RGS3/EPHA2/ROCK1/WNT5A/SEMA6B/PLXNA2/PTK2/ABL1/UNC5B/ARHGEF12/PPP3CB/SSH2/MET/RHOD/HRAS/GSK3B/EPHA4/SEMA4D/FYN/ENAH/PLXNA4/SRGAP3/WNT5B/NEO1/PLCG1/RAC1/ROBO3/TRPC4/MYL12B/ITGB1/BMPR2/CXCR4/EPHB2/GDF7/PLXNB1/PTCH1/SEMA4F/SSH3/SEMA6C/SEMA5A	5.09541312833398
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	88/2701	196/9376	1.55854596559098	ANGPT2/GNG12/CDKN1A/CLEC2B/NFATC1/HLA-B/HLA-A/HLA-F/AKT3/TCF7L1/HLA-E/MAP1LC3A/HLA-C/JAK1/UBC/PPP3CA/MYC/IKBKB/MAPKAPK2/STAT3/PPP3CC/GNB5/PIK3CB/HIF1A/NFATC2/ZFP36/TBK1/MAPK3/TCF7L2/MAP1LC3B/PIK3R3/NFKBIA/BECN1/STAT1/GNB1/PLCG2/RELA/PTGS2/VEGFA/IRF3/CYCS/TNFRSF1A/MAPK1/TRAF3/CXCL2/CREB1/TICAM1/IFNAR1/E2F3/EIF2AK2/FGF2/PPP3CB/MAP2K1/MAPK8/ITPR3/PIK3C3/HRAS/GSK3B/CXCL1/MTOR/MAP2K4/CREBBP/GNG11/C3/EP300/PLCG1/RCAN1/CASP3/IRF7/CALML4/RAC1/MICA/PDGFB/IL6/MAPK12/TRAF2/AKT2/MAPK11/ICAM1/MAP2K7/CXCL3/TYK2/LEF1/GNGT2/MICB/MAP2K6/TLR3/JAK2	5.02675721072796
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	59/2701	119/9376	1.72106813847346	CREB5/AKT3/IKBKB/IRF1/IL15/PIK3CB/MLKL/BCL3/MAPK3/TNFAIP3/PIK3R3/VCAM1/NFKBIA/RELA/SELE/FRMD8/PTGS2/TNFRSF1A/RIPK1/MAPK1/DAB2IP/TRAF3/CXCL2/MAP3K14/ADAM17/CASP7/ATF2/CREB1/MAP2K3/DNM1L/CX3CL1/MAP2K1/MAPK8/VEGFC/SOCS3/CXCL1/CSF1/CASP10/MAP2K4/LIF/CFLAR/ITCH/TRAF5/ATF6B/BIRC3/CREB3L2/CASP3/IL6/MAPK12/TRAF2/AKT2/MAPK11/ICAM1/MAP2K7/CXCL3/MAP2K6/IL18R1/TRAF1/EDN1	5.03543448829908
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	79/2701	174/9376	1.57605314336538	DNAJB1/HSPH1/CRYAB/WFS1/CAPN2/PPP1R15A/DAD1/HSPA1A/HSPA1B/ATXN3/DDIT3/SVIP/BCAP29/HSP90AB1/HSPA8/BCAP31/DNAJA1/OS9/ATF6/UBQLN1/HSPA6/VCP/HSP90AA1/SEC62/UBE2G1/UBE2G2/NPLOC4/KRTCAP2/SSR4/ERN1/UBXN4/EIF2S1/CUL1/SEC24D/RAD23B/RNF185/NFE2L2/STUB1/UBE2J1/UBE2D2/BCL2/SEC63/PRKN/LMAN1/UBXN1/DNAJC3/UFD1/UBE2D3/BAG1/TXNDC5/GANAB/RRBP1/SEC24B/HSPA4L/RNF5/SEC31A/DERL1/MAPK8/SEC24A/UGGT2/EDEM3/NGLY1/ERO1B/HSPA5/DNAJC5G/ATF6B/MBTPS1/SEC24C/DNAJC1/UBE4B/EIF2AK3/UBXN2A/HSPBP1/TRAF2/HYOU1/SEC61A2/MAP2K7/HSPA1L/SEC31B	4.87885999589419
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	53/2701	105/9376	1.75218349464925	MAP1LC3A/OPTN/UBC/SQSTM1/RRAS2/GABARAPL1/CALCOCO2/HIF1A/TBC1D15/TBK1/VCP/MAP1LC3B/BECN1/EIF2S1/RELA/SMURF1/HUWE1/PINK1/GABARAPL2/PRKN/CSNK2B/ULK1/RAB7A/RAB5A/CSNK2A1/MON1B/BCL2L13/MAPK8/USP8/TFE3/HRAS/PHB2/SP1/RABGEF1/SMURF2/CSNK2A2/OPA1/BNIP3/CCZ1/TFEB/MFN1/AMBRA1/MFN2/TOMM70/EIF2AK3/ARIH1/MRAS/CCZ1B/FOXO3/TRAF2/SAMM50/ATG9A/RAB7B	4.9303466303617
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	54/2701	109/9376	1.71973003542691	RORA/TGFBR2/NFATC1/HLA-DRB1/JAK1/HLA-DPA1/PPP3CA/HLA-DPB1/HLA-DRB5/IKBKB/STAT3/PPP3CC/HSP90AB1/HLA-DQB1/SMAD3/HIF1A/NFATC2/MAPK3/HSP90AA1/IL4R/NFKBIA/HLA-DMA/STAT1/RELA/SMAD2/HLA-DRA/STAT5B/IL1R1/NFKBIB/STAT5A/AHR/MAPK1/SMAD4/RARA/HLA-DQA1/IL6R/HLA-DQA2/PPP3CB/MAPK8/MTOR/HLA-DOA/PLCG1/PRKCQ/NFKBIE/IL6/MAPK12/MAPK11/TYK2/IFNG/LCK/CD3E/LAT/HLA-DQB2/JAK2	4.80768040214056
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	58/2701	120/9376	1.6777983462915	SHC1/RPS6KA2/AKT3/GAB1/RPS6KA3/RAP1B/IKBKB/MAPKAPK2/IRAK2/PIK3CB/PTPN11/MAPK3/PIK3R3/NFKBIA/CAMK2D/PLCG2/RELA/BRAF/MAP3K3/NFKBIB/BCL2/ARHGDIA/PSEN1/MAPK1/IRAK3/MAP3K1/MAGED1/ABL1/KIDINS220/MAP2K1/MAPK8/IRAK4/SOS2/HRAS/GSK3B/YWHAE/TRAF6/ZNF274/RAP1A/PRDM4/SH2B1/PLCG1/RIPK2/MAPK7/CALML4/RAC1/NFKBIE/PSEN2/FOXO3/MAPK12/AKT2/MAPK11/RPS6KA6/MAP2K7/NTF3/SHC2/NGF/NTRK1	4.75337141570787
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	54/2701	110/9376	1.70409612601393	ANGPT2/TIMP1/CDKN1A/INSR/AKT3/SERPINE1/PFKP/STAT3/LDHA/PIK3CB/HK1/HIF1A/MAPK3/ELOC/PIK3R3/PFKFB3/CAMK2D/PLCG2/EGLN3/RELA/VEGFA/ENO1/BCL2/NOS3/EIF4E/MAPK1/GAPDH/LTBR/RPS6KB1/IL6R/EGLN1/EGFR/MAP2K1/MTOR/HMOX1/CREBBP/MKNK2/EP300/PDHA1/PLCG1/IL6/TF/AKT2/IGF1R/FLT1/VHL/PFKM/ALDOC/HK2/ALDOB/ALDOA/IFNG/EDN1/ENO2	4.72502863420967
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	122/2701	300/9376	1.41166481550043	ANGPT2/HSPB1/GNG12/TGFBR2/FLT4/NFATC1/INSR/RPS6KA2/AKT3/EFNA5/RASGRP3/RELB/PDGFD/FLNA/NR4A1/PPP3CA/DUSP5/HSPA1A/HSPA1B/MYC/RPS6KA3/RAP1B/RRAS2/IKBKB/MAPKAPK2/DDIT3/PPP3CC/HSPA8/TGFB2/DUSP16/PDGFA/PLA2G4C/HSPA6/FGFR1/MAPK3/JUND/GADD45A/ELK4/RELA/MAP3K13/BRAF/DUSP6/EFNA1/MAP3K3/IL1R1/CACNB2/MAX/PAK2/VEGFA/ARRB1/TNFRSF1A/MAPK1/MAP3K14/GNA12/PGF/ATF2/MAP3K1/EPHA2/DUSP2/NFKB2/MAP2K3/FGF2/PPP3CB/PPM1B/EGFR/MAP2K1/STK3/MAPK8/MAP3K4/VEGFC/IRAK4/MET/SOS2/MAP4K4/HRAS/PPP5C/NF1/RET/CSF1/TAOK1/MAP2K4/TRAF6/ECSIT/MAPK8IP3/RAP1A/CDC25B/MKNK2/DAXX/GADD45B/NLK/CASP3/MAPK7/RAC1/ARAF/CACNA1C/PDGFB/MRAS/DUSP4/MAPK12/TRAF2/AKT2/DUSP10/PTPN5/FLT3LG/ELK1/MAPK11/GADD45G/IGF1R/RPS6KA6/TGFB3/MAP2K7/FLT1/NTF3/MAP3K10/PLA2G4A/HSPA1L/NGF/PTPN7/MAP2K6/MAPK8IP1/NTRK1/RASGRP1	4.60977182306047
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	46/2701	90/9376	1.7742235386071	NFATC1/AKT3/JAK1/PPP3CA/IKBKB/STAT3/PPP3CC/PIK3CB/HIF1A/NFATC2/PTPN11/MAPK3/PIK3R3/NFKBIA/STAT1/RELA/MAP3K3/NFKBIB/CSNK2B/MAPK1/CD274/TICAM1/RPS6KB1/MAP2K3/CSNK2A1/PPP3CB/EGFR/MAP2K1/HRAS/MTOR/TRAF6/CSNK2A2/BATF3/PLCG1/PRKCQ/NFKBIE/MAPK12/AKT2/MAPK11/IFNG/MAP2K6/LCK/CD3E/LAT/JAK2/RASGRP1	4.69456742909071
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	49/2701	98/9376	1.73565346168086	ITPKC/INPP4B/PLCE1/PIK3CB/PLCB4/MTMR6/INPP1/PIK3C2A/PIK3R3/PIP5K1A/PLCG2/INPP5A/IP6K2/CDS2/CDIPT/DGKE/SYNJ2/PIP4K2A/IMPA1/ITPR3/PIK3C3/ITPKB/IP6K1/MTMR3/MTMR2/INPP5B/PIP5K1C/PI4K2B/DGKH/ITPK1/PLCG1/MTMR8/IPPK/OCRL/CALML4/PIP4P1/MTMR1/MTMR4/PLCB1/IMPA2/DGKA/PIP4K2C/DGKD/DGKI/PPIP5K1/DGKQ/PLCD4/PLCD1/INPP5E	4.65673400962834
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	35/2701	63/9376	1.92850384631207	KMT2E/SMYD2/AASS/KMT2A/PHYKPL/ALDH2/HADHA/PRDM2/EHMT1/ALDH9A1/DLST/KMT2C/SETD7/SETD2/KMT5B/EZH1/NSD3/ALDH3A2/CAMKMT/EZH2/ASH1L/ACAT1/PLOD3/SMYD3/DOT1L/PLOD2/KMT2D/NSD2/KMT2B/SETDB2/DHTKD1/SETD1A/HYKK/EHHADH/SETMAR	4.70361184815813
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	41/2701	78/9376	1.82466133151065	ITPKC/INPP4B/PLCE1/PIK3CB/PLCB4/MTMR6/INPP1/PIK3C2A/PIP5K1A/PLCG2/TPI1/INPP5A/IP6K2/CDIPT/SYNJ2/PIP4K2A/IMPA1/PIK3C3/ITPKB/IP6K1/MTMR3/MTMR2/INPP5B/PIP5K1C/PI4K2B/ITPK1/PLCG1/MTMR8/IPPK/INPP5K/OCRL/MTMR1/MTMR4/PLCB1/IMPA2/PIP4K2C/ALDH6A1/PPIP5K1/PLCD4/PLCD1/INPP5E	4.65211515729405
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	50/2701	101/9376	1.71846877394144	FOXO1/TGFBR2/NFATC1/PLCE1/AKT3/SERPINE1/STAT3/PRKCZ/THBD/DIAPH1/TGFB2/SMAD3/PRKCE/PIK3CB/PLCB4/MAPK3/PIK3R3/VCAM1/STAT1/PLCG2/RELA/SMAD2/SELE/STAT5B/MMP2/VEGFA/BCL2/STAT5A/NOS3/MAPK1/SMAD4/COL4A5/MAPK8/VEGFC/HRAS/PLCG1/CASP3/RAC1/NOX4/IL6/MAPK12/AKT2/MAPK11/PLCB1/ICAM1/TGFB3/PLCD4/PLCD1/EDN1/JAK2	4.61778725344137
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	44/2701	87/9376	1.75560350147029	TGFBR2/CDKN1A/RALGDS/AKT3/TCF7L1/MYC/TGFB2/SMAD3/PIK3CB/MAPK3/TCF7L2/RALB/PIK3R3/GADD45A/POLK/SMAD2/BRAF/BCL2/CYCS/MAPK1/SMAD4/MLH1/BCL2L11/RPS6KB1/RALA/EGFR/MAP2K1/MAPK8/APC/SOS2/HRAS/GSK3B/MTOR/GADD45B/CASP3/RAC1/AXIN1/ARAF/DDB2/AKT2/GADD45G/TGFB3/BBC3/LEF1	4.50392761291678
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	42/2701	83/9376	1.75656494917099	SFMBT2/PHC2/JARID2/L3MBTL4/ASXL1/CBX3/MAX/UBE2D2/KDM2A/SCMH1/HDAC1/CSNK2B/YAF2/UBE2D3/FOXK1/PHF1/RBBP4/SUZ12/L3MBTL3/EZH1/E2F6/TEX10/EZH2/RING1/RYBP/CREBBP/PCGF2/PHC3/SCML2/EP300/PCGF3/PCGF5/HCFC1/USP45/CBX7/L3MBTL1/FBRS/PHC1/ASXL3/EPOP/WDR5/PCGF6	4.40382030866807
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	94/2701	227/9376	1.4374574924934	GNG12/CREB5/CDKN1A/NFATC1/HLA-B/HLA-A/HLA-F/AKT3/HLA-E/HLA-C/JAK1/BCAR1/PPP3CA/MYC/IKBKB/STAT3/PXN/TAPBP/PPP3CC/GNB5/ITGAV/PIK3CB/PLCB4/NFATC2/ADCY4/TBK1/MAPK3/TAP1/PIK3R3/NFKBIA/ITGB3/GNB1/ROCK2/RELA/PTK2B/IL1R1/PTGS2/VEGFA/IRF3/TAP2/CYCS/TNFRSF1A/RIPK1/MAPK1/GNAI3/GNA12/ATF2/AKAP13/CREB1/ROCK1/E2F3/RPS6KB1/IL6R/PTK2/ARHGEF12/PPP3CB/EGFR/CX3CL1/MAP2K1/SOS2/ITPR3/HRAS/GSK3B/MTOR/SP1/GNA11/TRAF5/ATF6B/MDM2/GNG11/CGAS/CREB3L2/PTGER3/CASP3/CALML4/RAC1/GNAQ/ARHGEF1/ARHGEF11/IL6/TAPBPL/MAPK12/TRAF2/AKT2/ELK1/MAPK11/PLCB1/GNAS/ADCY6/CXCR4/GNGT2/MAP2K6/GNAO1/ADCY1	4.24408691550895
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	69/2701	157/9376	1.5256062274647	SMAD1/WWTR1/TGFBR2/FRMD6/SERPINE1/PARD6G/TCF7L1/CCN2/PPP2R1B/YWHAG/DLG2/BMP2/TEAD4/CCND3/FZD6/MYC/PRKCZ/TEAD1/CTNNA1/PARD3/TGFB2/SMAD3/YWHAQ/LATS2/TEAD2/YAP1/DLG1/TCF7L2/TP53BP2/SMAD2/YWHAH/CSNK1E/FBXW11/RASSF1/PATJ/PPP2R2D/FZD8/SMAD4/YWHAZ/CSNK1D/WNT5A/PPP2CA/AMOT/STK3/PPP2CB/APC/SAV1/GSK3B/BMP6/LIMD1/YWHAE/YWHAB/PRKCI/WNT5B/BIRC3/AXIN1/ACTG1/NF2/WTIP/SNAI2/WNT9A/LLGL2/BMPR2/TGFB3/WNT2B/BBC3/GDF7/DVL1/LEF1	4.22464981931143
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	71/2701	163/9376	1.51204166600418	TGFBR2/CREB5/CDKN1A/NFATC1/AKT3/JAK1/HSPG2/MYC/IKBKB/STAT3/TGFB2/SMAD3/YWHAQ/PIK3CB/NFATC2/TBK1/MAPK3/PIK3R3/NFKBIA/STAT1/RELA/BRAF/STAT5B/PTK2B/IRF3/BCL2/CYCS/STAT5A/MAPK1/SMAD4/TRAF3/YWHAZ/ATF2/MAP3K1/CREB1/TICAM1/IFNAR1/E2F3/MAP2K3/MAP2K1/MAPK8/IRAK4/SOS2/HRAS/CASP10/YWHAB/MAP2K4/TRAF6/EGR3/CREBBP/ATF6B/IFIH1/EP300/CREB3L2/CASP3/IRF7/ARAF/DDB2/IL6/MAPK12/AKT2/DDX3X/ELK1/MAPK11/TGFB3/MAP2K7/TYK2/CCNE2/MAP2K6/TLR3/JAK2	4.19489276992088
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	60/2701	133/9376	1.56600312332108	FOXO1/TGFBR2/CDKN1A/INSR/PRKAG2/AKT3/GABARAPL1/IKBKB/STAT3/TGFB2/SMAD3/HOMER1/SOD2/HOMER3/PIK3CB/PRKAA2/SGK3/MAPK3/PLK3/PIK3R3/GADD45A/BCL6/BRAF/CSNK1E/GABARAPL2/MAPK1/SMAD4/FBXO32/BCL2L11/SETD7/PRKAA1/EGFR/MAP2K1/MAPK8/SOS2/ATG12/HRAS/RBL2/FBXO25/CREBBP/PRKAG1/BNIP3/MDM2/DEPP1/G6PC3/EP300/GADD45B/NLK/ARAF/IL6/FOXO3/MAPK12/AKT2/MAPK11/GADD45G/IGF1R/TGFB3/KLF2/IRS2/IL7R	4.18177312259404
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	51/2701	109/9376	1.62418947790319	FOXO1/CREB5/INSR/PRKAG2/RPS6KA2/AKT3/RPS6KA3/IKBKB/STAT3/PRKCZ/PRKCE/PIK3CB/PRKAA2/PTPN11/ACACB/PIK3R3/CPT1A/NFKBIA/RELA/PPP1R3B/MLXIP/SLC27A3/TNFRSF1A/NOS3/NR1H2/CREB1/PTPN1/RPS6KB1/PRKAA1/MAPK8/SOCS3/GSK3B/PYGB/MTOR/GYS1/PRKAG1/SLC27A4/G6PC3/PRKCQ/CREB3L2/GFPT2/IL6/AKT2/PPP1R3E/RPS6KA6/MLX/TRIB3/IRS2/SLC27A1/PTPRF/PPP1R3C	4.16948490743134
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	73/2701	170/9376	1.4906200317965	TGFBR2/SHC1/CDKN1A/AKT3/TCF7L1/FZD6/GAB1/MYC/TGFB2/SMAD3/PIK3CB/MAPK3/TCF7L2/MGST2/PIK3R3/GADD45A/PLCG2/LRP5/POLK/SMAD2/BRAF/SMARCA2/SMARCE1/MGST3/NFE2L2/SMARCC1/TXNRD1/GSTO1/FZD8/MAPK1/SMAD4/ARID1B/WNT5A/SMARCA4/E2F3/RPS6KB1/CSNK1A1/SMARCC2/EGFR/MAP2K1/APC/MET/SOS2/HRAS/GSTM3/GSK3B/MTOR/HMOX1/WNT5B/SMARCD1/MGST1/PLCG1/GADD45B/GSTT2B/ARID2/AXIN1/ARAF/DDB2/ACTG1/AKT2/ELK1/WNT9A/PHF10/GADD45G/IGF1R/TGFB3/WNT2B/SHC2/DVL1/TXNRD3/LEF1/GSTO2/GSTM2	4.10635551964461
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	21/2701	34/9376	2.14404251148812	RORA/PRKAG2/CRY1/NFIL3/PRKAA2/PER1/BHLHE40/NPAS2/CUL1/RORB/CSNK1E/FBXW11/PER3/CRY2/PER2/CSNK1D/NR1D2/CREB1/PRKAA1/NR1D1/PRKAG1	4.25093030857489
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	76/2701	180/9376	1.46566292319717	HLA-DRB1/HLA-B/HLA-A/HLA-F/AKT3/HLA-E/HLA-C/JAK1/CD74/HLA-DPA1/HLA-DPB1/HLA-DRB5/IKBKB/TAPBP/HLA-DQB1/PIK3CB/SRSF4/ITGA5/PTPN11/TBK1/TAP1/PIK3R3/NFKBIA/ITGB3/SRPK1/HLA-DMA/STAT1/EIF2S1/SP100/RELA/HLA-DRA/NECTIN2/POU2F1/IRF3/TAP2/BCL2/CYCS/TNFRSF1A/PML/TRAF3/PILRB/TICAM1/TNFRSF14/IFNAR1/EIF2AK2/HLA-DQA1/OAS1/HLA-DQA2/EIF2B2/IRAK4/SOCS3/MTOR/ZC3HAV1/TRAF6/TRAF5/DAXX/IFIH1/HLA-DOA/C3/BIRC3/CGAS/CASP3/IRF7/OAS2/HCFC1/EIF2B5/IL6/TAPBPL/TRAF2/AKT2/TYK2/EIF2B1/IFNG/HLA-DQB2/TLR3/JAK2	4.01264488338386
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	128/2701	333/9376	1.33431617474565	FOXO1/RELN/CREB5/CDKN1A/VWF/TNXB/THBS1/MAGI1/HLA-B/HLA-A/HLA-F/AKT3/PARD6G/TCF7L1/LAMA4/PPP2R1B/HLA-E/HLA-C/DLG2/JAK1/ITGA9/ITGB4/CCND3/PKM/LAMA3/FZD6/LAMB1/IKBKB/TNC/PXN/PRKCZ/ITGA1/PARD3/BCAP31/ITGAV/PPP2R5C/IRF1/PIK3CB/ITGA6/ITGA5/DLG1/TBK1/MAPK3/TCF7L2/PPP2R3A/PIK3R3/HES4/ITGB3/STAT1/RELA/HES1/PPP2R5A/PTGS2/VEGFA/IRF3/LAMB2/PPP2R5E/TNFRSF1A/HDAC1/PATJ/PPP2R2D/FZD8/NFX1/PSEN1/MAPK1/TRAF3/MX1/TBPL1/NOTCH1/CREB1/WNT5A/TICAM1/PPP2CA/IFNAR1/RPS6KB1/EIF2AK2/CSNK1A1/PPP2R3C/PTK2/COL4A5/ATR/EGFR/MAP2K1/ITGA8/PPP2CB/APC/SOS2/HRAS/GSK3B/RBL2/THBS3/UBR4/MTOR/ISG15/PRKCI/CREBBP/MDM2/WNT5B/EP300/RFNG/CREB3L2/CASP3/PPP2R5B/PPP2R5D/AXIN1/ITGA10/ATP6V0A2/MAML1/LAMC1/THBS2/ITGB1/AKT2/COL6A3/WNT9A/GNAS/ITGB8/LLGL2/WNT2B/ITGA11/TYK2/TUBG2/DVL1/TBP/ITGA7/OASL/CCNE2/ATP6V1E2/TLR3	3.95135032331626
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	61/2701	138/9376	1.53441827771786	NFATC1/ARHGEF28/RPS6KA2/AKT3/SKAP2/BCAR1/RPS6KA3/VAV3/DOCK1/IKBKB/PXN/ARPC5L/ARHGEF7/PIK3CB/NFATC2/ITGA5/TBK1/MAPK3/PIK3R3/NFKBIA/ROCK2/PIP5K1A/RELA/PTK2B/IRF3/MAPK1/ROCK1/TICAM1/MAP2K3/PTK2/ARHGEF12/MAP2K1/MAPK8/IRAK4/GSK3B/MAP2K4/TRAF6/WIPF2/PIP5K1C/BAIAP2/PLCG1/RAC1/GNAQ/ARHGEF1/ACTG1/IL6/ITGB1/MAPK12/TRAF2/AKT2/MAPK11/RPS6KA6/MAP2K7/ELMO1/WIPF3/ACTR3B/ACTR3C/MAP2K6/LCK/LAT/CD8A	4.02303825798193
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	55/2701	122/9376	1.56493344905651	NFATC1/CBLB/AKT3/PPP2R1B/PPP3CA/VAV3/IKBKB/PPP3CC/PPP2R5C/PIK3CB/BCL10/NFATC2/PTPN11/DLG1/MAPK3/PPP2R3A/PIK3R3/NFKBIA/NCK1/RELA/PPP2R5A/PAK3/PAK2/NFKBIB/MALT1/PPP2R5E/PPP2R2D/MAPK1/MAP3K14/PPP2CA/PPP2R3C/PPP3CB/MAP2K1/MAPK8/PPP2CB/SOS2/HRAS/GSK3B/FYN/PLCG1/PRKCQ/PPP2R5B/PPP2R5D/NFKBIE/MAPK12/AKT2/MAPK11/MAP2K7/ITK/IFNG/LCK/CD3E/LAT/CD8A/RASGRP1	3.99516529671394
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	22/2701	37/9376	2.06402033280967	CDKN1A/TCF7L1/MYC/MAPK3/TCF7L2/GADD45A/POLK/BRAF/MAPK1/CCDC6/TFG/TPR/MAP2K1/HRAS/TPM3/RET/PPARG/GADD45B/DDB2/GADD45G/LEF1/NTRK1	4.12498996876453
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	137/2701	362/9376	1.31372665331645	ANGPT2/RELN/GNG12/CREB5/FLT4/CDKN1A/VWF/TNXB/THBS1/MAGI1/INSR/AKT3/EFNA5/IL7/LAMA4/PPP2R1B/YWHAG/JAK1/ITGA9/ITGB4/PDGFD/MCL1/CCND3/NR4A1/LAMA3/LAMB1/MYC/IKBKB/TNC/GHR/ITGA1/HSP90AB1/GNB5/YWHAQ/OSMR/ITGAV/PPP2R5C/PIK3CB/PDGFA/PRKAA2/CDC37/ITGA6/ITGA5/FGFR1/SGK3/MAPK3/HSP90AA1/CSF3/PPP2R3A/MAGI2/IL4R/PIK3R3/ITGB3/GNB1/IL3RA/RELA/YWHAH/EFNA1/PPP2R5A/VEGFA/BCL2/LAMB2/PPP2R5E/PPP2R2D/NOS3/EIF4E/MAPK1/YWHAZ/PGF/ATF2/BCL2L11/CREB1/EPHA2/PHLPP2/PPP2CA/IFNAR1/EIF4B/RPS6KB1/IL6R/DDIT4/FGF2/PPP2R3C/PTK2/COL4A5/PRKAA1/EGFR/RPTOR/MAP2K1/ITGA8/PPP2CB/VEGFC/MET/SOS2/HRAS/GSK3B/RBL2/RET/YWHAE/THBS3/CSF1/THEM4/MTOR/YWHAB/GYS1/ATF6B/MDM2/PKN3/GNG11/G6PC3/CREB3L2/RAC1/PPP2R5B/PPP2R5D/ITGA10/LAMC1/THBS2/PDGFB/IL6/ITGB1/FOXO3/PHLPP1/AKT2/FLT3LG/COL6A3/IGF1R/ITGB8/FLT1/NTF3/ITGA11/BRCA1/IL7R/ITGA7/GNGT2/NGF/CCNE2/NTRK1/JAK2	3.87230199877313
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	40/2701	82/9376	1.69332045042035	HLA-DRB1/HLA-B/HLA-A/HLA-F/HLA-E/HLA-C/CD74/HSPA4/HLA-DPA1/HLA-DPB1/HSPA1A/HLA-DRB5/HSPA1B/TAPBP/HSP90AB1/HSPA8/HLA-DQB1/HSPA6/HSP90AA1/TAP1/HLA-DMA/PSME1/HLA-DRA/PSME2/TAP2/CIITA/CREB1/HLA-DQA1/HLA-DQA2/NFYC/HSPA5/HLA-DOA/PSME3/TAPBPL/KLRD1/HSPA1L/IFNG/RFX5/HLA-DQB2/CD8A	4.01108530064249
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	38/2701	77/9376	1.71311250763306	TGFBR2/CDKN1A/RALGDS/AKT3/JAK1/IKBKB/STAT3/TGFB2/SMAD3/PIK3CB/MAPK3/RALB/PIK3R3/GADD45A/STAT1/POLK/RELA/SMAD2/BRAF/RALBP1/VEGFA/MAPK1/SMAD4/E2F3/RPS6KB1/RALA/EGFR/MAP2K1/MAPK8/MTOR/GADD45B/RAC1/ARAF/DDB2/PLD2/AKT2/GADD45G/TGFB3	3.99675556031012
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	38/2701	77/9376	1.71311250763306	TGFBR2/SHC1/CDKN1A/BCR/AKT3/CTBP2/MYC/IKBKB/TGFB2/SMAD3/PIK3CB/PTPN11/MAPK3/PIK3R3/GADD45A/NFKBIA/POLK/RELA/BRAF/STAT5B/HDAC1/STAT5A/MAPK1/SMAD4/E2F3/ABL1/MAP2K1/SOS2/HRAS/MDM2/CBL/GADD45B/ARAF/DDB2/AKT2/GADD45G/TGFB3/SHC2	3.99675556031012
NA	NA	hsa04518	Integrin signaling	66/2701	154/9376	1.48770296715502	ACTN1/RELN/FLT4/VWF/LIMS1/TNXB/THBS1/AKT3/LAMA4/ITGA9/ITGB4/PDGFD/FLNA/CCND3/FLNB/LAMA3/LAMB1/TNC/PXN/ITGA1/FBN1/PARVA/ITGAV/NPNT/PIK3CB/PDGFA/ITGA6/ITGA5/PARVB/PIK3R3/VCAM1/ITGB3/TLN1/VEGFA/LAMB2/FERMT2/ILK/PGF/PTK2/COL4A5/EGFR/VCL/LIMS2/ITGA8/VEGFC/MET/GSK3B/THBS3/MTOR/ITGAE/C3/RAC1/ITGA10/LAMC1/THBS2/PDGFB/ACTG1/ITGB1/AKT2/COL6A3/IGF1R/ITGB8/ICAM1/FLT1/ITGA11/ITGA7	3.88173152414428
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	67/2701	157/9376	1.48138575710341	FOXO1/TGFBR2/CDKN1A/NFATC1/HIPK3/ETS1/HLA-B/HLA-A/HLA-F/AKT3/SERPINE1/HLA-E/HLA-C/CAPN2/CCND3/SQSTM1/PPP3CA/MCU/MYC/RRAS2/MAPKAPK2/ZFP36L2/PPP3CC/TGFB2/SMAD3/PIK3CB/NFATC2/MAPK3/PIK3R3/GADD45A/RELA/SMAD2/HIPK2/RAD9A/FBXW11/HIPK1/MAPK1/E2F3/MAP2K3/RBBP4/PPP3CB/ATR/TRPM7/MAP2K1/ITPR3/HRAS/RBL2/MTOR/TRAF3IP2/MDM2/GADD45B/CALML4/MRE11/MRAS/IL6/HUS1/FOXO3/MAPK12/AKT2/MAPK11/RAD50/GADD45G/TGFB3/LIN54/LIN52/CCNE2/MAP2K6	3.86922023655547
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	20/2701	33/9376	2.10382237779498	VAMP5/VAMP3/STX11/SNAP23/STX8/VAMP2/STX5/STX2/STX4/STX17/STX6/GOSR1/VTI1A/STX18/STX16/GOSR2/YKT6/STX1A/VAMP1/STX19	4.04050161845935
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	87/2701	216/9376	1.39816528857625	NFATC1/AKT3/HSPA4/PPP3CA/HSPD1/HSPA1A/HSPA1B/VAV3/RAP1B/IKBKB/STAT3/DDIT3/LDLR/PPP3CC/HSP90AB1/HSPA8/TNFRSF10B/SOD2/PIK3CB/PLCB4/ATF6/NFATC2/HSPA6/TBK1/MAPK3/HSP90AA1/ERN1/PIK3R3/VCAM1/NFKBIA/CAMK2D/EIF2S1/ROCK2/CD40/RELA/SELE/ABCG1/NFE2L2/POU2F1/IRF3/BCL2/CYCS/TNFRSF1A/NOS3/MAPK1/TRAF3/CXCL2/CASP7/TICAM1/MAP2K3/PTK2/TNFRSF10A/PPP3CB/MAPK8/IRAK4/HRAS/GSK3B/CXCL1/PPARG/MAP2K4/TRAF6/RAP1A/HSPA5/PLCG1/CASP3/IRF7/CALML4/RAC1/EIF2AK3/ARHGEF1/IL6/MAPK12/TRAF2/AKT2/MAPK11/VLDLR/PLCB1/ICAM1/MAP2K7/CXCL3/CASP6/APOB/HSPA1L/MIB2/APOA1/MAP2K6/JAK2	3.76586571991962
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	47/2701	103/9376	1.58399442133981	PPP2R1B/SMG6/PPP2R5C/DDX39B/PPP2R3A/NXT1/SMG1/RBM8A/FUS/PPP2R5A/PAPOLA/RNPS1/SMG7/PPP2R5E/PPP2R2D/GSPT1/CASC3/UPF3A/PNN/WDR33/TARDBP/ACIN1/PPP2CA/UPF2/PPP2R3C/CPSF6/SSU72/DAZAP1/RNGTT/PPP2CB/CSTF3/ETF1/UPF3B/SMG5/SYMPK/PELO/CPSF7/DDX19B/HBS1L/DDX19A/UPF1/PAPOLG/PPP2R5B/PPP2R5D/GSPT2/BCL2L2-PABPN1/MSI2	3.7908751043857
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	92/2701	232/9376	1.37655274547103	ACTN1/GNG12/GSN/AKT3/SSH1/MYL9/ITGA9/ITGB4/LIMK2/PDGFD/BCAR1/MYH11/VAV3/RRAS2/DOCK1/MYH9/PXN/DIAPH1/ARPC5L/ARHGEF7/ITGA1/SPATA13/RDX/ITGAV/MYH10/PIK3CB/PDGFA/ITGA6/DIAPH2/ITGA5/TIAM1/FGFR1/MAPK3/MYL12A/PIK3R3/NCKAP1/ITGB3/MSN/ROCK2/PIP5K1A/PPP1R12B/BRAF/PAK3/PAK2/PPP1R12C/BDKRB2/IQGAP1/MAPK1/BRK1/GNA12/CFL2/ROCK1/GIT1/WASF1/FGF2/PTK2/ARHGEF12/SSH2/EGFR/PIP4K2A/VCL/MAP2K1/ITGA8/APC/SOS2/HRAS/ENAH/PIP5K1C/BAIAP2/ITGAE/ARHGAP35/RAC1/ITGA10/ARHGEF1/ARAF/MYL12B/PDGFB/ACTG1/MRAS/ITGB1/AKT2/ITGB8/PIP4K2C/ITGA11/RGCC/CXCR4/BDKRB1/ACTR3B/ITGA7/ACTR3C/SSH3/CHRM5	3.69423056694291
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	43/2701	93/9376	1.60501287854359	NFATC1/HLA-DRB1/JAK1/HLA-DPA1/PPP3CA/HLA-DPB1/HLA-DRB5/IKBKB/PPP3CC/HLA-DQB1/NFATC2/MAPK3/IL4R/NFKBIA/HLA-DMA/STAT1/RELA/HLA-DRA/STAT5B/NFKBIB/STAT5A/MAPK1/NOTCH1/HLA-DQA1/HLA-DQA2/PPP3CB/MAPK8/HLA-DOA/PLCG1/PRKCQ/NFKBIE/MAML1/MAPK12/MAPK11/TYK2/DLL1/IFNG/LCK/CD3E/LAT/HLA-DQB2/JAK2/RUNX3	3.72978856935127
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	30/2701	59/9376	1.76507131696359	CDKN1A/AKT3/TCF7L1/MYC/CTNNA1/PIK3CB/MAPK3/TCF7L2/PIK3R3/GADD45A/POLK/BRAF/MAPK1/ILK/MLH1/EGFR/MAP2K1/APC/SOS2/HRAS/GSK3B/GADD45B/AXIN1/ARAF/DDB2/FOXO3/AKT2/ELK1/GADD45G/LEF1	3.74983513193038
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	38/2701	80/9376	1.64887078859682	SHC1/AKT3/JAK1/PDGFD/GAB1/STAT3/PIK3CB/PDGFA/MAPK3/PIK3R3/GAS6/PLCG2/BRAF/VEGFA/BCL2/EIF4E/MAPK1/BCL2L11/RPS6KB1/IL6R/FGF2/EGFR/MAP2K1/MET/SOS2/HRAS/GSK3B/NF1/MTOR/PLCG1/ARAF/PDGFB/IL6/FOXO3/AKT2/IGF1R/SHC2/JAK2	3.70746836875214
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	19/2701	32/9376	2.06108848574602	GABARAPL1/BECN1/ATG101/GABARAPL2/ATG2B/ATG4B/PPP2CA/IGBP1/ATG5/RPTOR/PPP2CB/PIK3C3/ATG12/MTOR/PIK3R4/ATG13/ULK2/ATG9A/ATG4A	3.82456874356897
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	66/2701	158/9376	1.45003960089793	CDKN1A/PPP2R1B/YWHAG/CCND3/MYC/TGFB2/SMAD3/YWHAQ/PPP2R5C/ANAPC16/ANAPC5/GADD45A/CUL1/CDKN2C/SMAD2/CDC27/YWHAH/PDS5A/PPP2R5A/WEE1/PPP2R5E/HDAC1/ZBTB17/TFDP2/SMAD4/YWHAZ/CDC26/PPP2CA/E2F3/CDC14B/ANAPC7/ABL1/CCNH/ATR/STAG1/PPP2CB/GSK3B/BUB3/RBL2/YWHAE/YWHAB/CDC14A/MAD2L2/CDC25B/CREBBP/MDM2/ORC2/CDK7/EP300/GADD45B/CDC16/PPP2R5B/PPP2R5D/ANAPC4/NIPBL/ANAPC1/FZR1/ESCO1/ORC3/GADD45G/ORC5/TGFB3/DBF4B/CDC7/CCNE2/MAD2L1BP	3.6289686609238
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	34/2701	70/9376	1.68606336277569	CDKN1A/ETS1/AKT3/GAB1/RAP1B/TGFB2/PIK3CB/HIF1A/PTPN11/MAPK3/ELOC/PIK3R3/EGLN3/BRAF/PAK3/PAK2/VEGFA/MAPK1/EGLN1/MAP2K1/MET/SOS2/TFE3/HRAS/FLCN/RAP1A/CREBBP/EP300/RAC1/ARAF/PDGFB/AKT2/TGFB3/VHL	3.66483156122463
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	53/2701	122/9376	1.50802677818173	FOXO1/CREB5/INSR/PRKAG2/AKT3/PPP2R1B/CAMKK2/PFKP/PPP2R5C/PIK3CB/PRKAA2/LEPR/PPP2R3A/ACACB/PIK3R3/CPT1A/PFKFB3/PPP2R5A/RAB14/PPP2R5E/PPP2R2D/STRADA/RAB11B/CREB1/CAB39/PPP2CA/ULK1/ELAVL1/RPS6KB1/RAB8A/TBC1D1/PPP2R3C/PRKAA1/RPTOR/PPP2CB/PPARG/ACACA/MTOR/GYS1/ADIPOR2/PRKAG1/G6PC3/CREB3L2/PPP2R5B/PPP2R5D/CAB39L/FOXO3/AKT2/HMGCR/IGF1R/IRS2/AKT1S1/PFKM	3.59272575802111
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	53/2701	122/9376	1.50802677818173	SHC1/CREB5/AKT3/SOCS2/BCAR1/STAT3/GHR/PIK3CB/PLCB4/ADCY4/MAPK3/PIK3R3/STAT1/PLCG2/STAT5B/STAT5A/MAPK1/GNAI3/ATF2/MAP3K1/CREB1/MAP2K3/PTK2/MAP2K1/MAPK8/SOS2/ITPR3/HRAS/SOCS3/GSK3B/MTOR/MAP2K4/CREBBP/GNA11/ATF6B/EP300/PLCG1/CREB3L2/GNAQ/CACNA1C/MAPK12/AKT2/MAPK11/PLCB1/GNAS/ADCY6/IRS2/SHC2/MRAP2/ADCY10/MAP2K6/JAK2/ADCY1	3.59272575802111
Cellular Processes	Cell motility	hsa04814	Motor proteins	78/2701	194/9376	1.39568010320729	MYO1D/TUBB6/ACTG2/MYO5C/MYL9/STARD9/MYH11/ACTA2/TPM4/MYH9/DYNC1I2/TUBB4B/KIFC3/KIF9/TPM2/MYH10/KLC1/DYNC1H1/KIF3C/DYNC1LI2/DCTN2/TUBA1A/MYO18A/MYO1E/MYO6/MYL12A/DNAH14/HOOK3/DYNC1I1/KIF16B/DCTN3/KIF2A/KIF1C/MYO5A/DYNC1LI1/MYL6B/DYNLT1/DYNC2H1/KIFAP3/KIF13A/MYO1C/DYNLL1/MYO1B/DYNLT3/MYO9B/KIF17/TUBA1C/DCTN1/ACTR1A/MYO9A/TPM3/KIF3B/KIF13B/MYO19/KIF21A/MYO15B/TUBA4A/ACTR1B/DYNC2LI1/KIF27/DNAL1/DNAH6/MYL12B/TUBE1/ACTG1/KIF22/KIF3A/DYNLRB2/TUBG2/KIF21B/BICDL1/DNAL4/MYL6/TUBB3/DNAH1/KIF26A/KLC2/KIFC2	3.54240920990647
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	30/2701	60/9376	1.73565346168086	HSPB1/SPHK1/AKT3/PPP3CA/MAPKAPK2/PXN/PPP3CC/PIK3CB/NFATC2/PLA2G4C/MAPK3/PIK3R3/PLCG2/PTGS2/VEGFA/NOS3/MAPK1/PTK2/PPP3CB/MAP2K1/HRAS/PLCG1/RAC1/MAPK12/AKT2/MAPK11/SHC2/PLA2G4A/SPHK2/SH2D2A	3.63627285107496
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	39/2701	85/9376	1.59271729424832	PNP/GUK1/UPP1/UCK2/NT5E/AK2/NME1/ENTPD4/ADA/NT5C2/NME7/CDA/NT5C3A/AK3/CMPK1/DCTPP1/DGUOK/GMPS/NME2/NUDT16/AK1/ASMTL/ADK/DCTD/NT5C3B/CTPS1/IMPDH1/CTPS2/RRM1/AK9/GMPR2/UCKL1/AK4/GMPR/ENTPD5/ENTPD1/UCK1/AK7/NT5M	3.49179008392608
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	92/2701	238/9376	1.341849735081	ANGPT2/GNG12/SHC1/FLT4/RALGDS/INSR/ETS1/PLCE1/AKT3/EFNA5/ETS2/RASGRP3/PDGFD/GAB1/RASAL2/RAP1B/RRAS2/IKBKB/ABL2/GNB5/PLA1A/PIK3CB/PDGFA/PLA2G4C/PTPN11/TIAM1/FGFR1/TBK1/MAPK3/RALB/PIK3R3/GNB1/RALGAPA2/PLCG2/RELA/RALGAPA1/EFNA1/PAK3/RALBP1/PAK2/VEGFA/RASSF1/MAPK1/RGL2/PGF/EPHA2/SYNGAP1/SHOC2/FGF2/REL/RAB5A/ABL1/RALA/EGFR/MAP2K1/MAPK8/VEGFC/MET/SOS2/HRAS/NF1/CSF1/PLA2G12A/RASAL3/RASA3/RAPGEF5/RAP1A/GNG11/BRAP/PLCG1/RASA4/CALML4/RAC1/PDGFB/MRAS/PLA2G6/PLD2/AKT2/FLT3LG/ELK1/IGF1R/RIN1/RASA4B/FLT1/NTF3/SHC2/PLA2G4A/GNGT2/NGF/LAT/NTRK1/RASGRP1	3.39797707589946
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	46/2701	105/9376	1.5207630330918	CCL21/RELB/IKBKB/PPP1R13L/BCL10/TNFAIP3/GADD45A/VCAM1/NFKBIA/PLCG2/CD40/TRIM25/RELA/IL1R1/PTGS2/CARD10/BCL2/MALT1/TNFRSF1A/RIPK1/CSNK2B/ERC1/TRAF3/CXCL2/MAP3K14/TICAM1/LTBR/NFKB2/CSNK2A1/IRAK4/CXCL1/TRAF6/CFLAR/CSNK2A2/TRAF5/BIRC3/PLCG1/GADD45B/PRKCQ/TRAF2/GADD45G/ICAM1/CXCL3/LCK/LAT/TRAF1	3.41345201494799
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	47/2701	108/9376	1.51066134627778	IPO11/NUP153/NUP98/TNPO1/DDX39B/NXT1/RBM8A/KPNB1/KPNA4/RNPS1/SUMO3/IPO7/KPNA1/AHCTF1/RAN/CASC3/UPF3A/PNN/IPO5/RANGAP1/ACIN1/UPF2/TPR/TNPO3/NUP88/RANBP17/THOC1/KPNA3/THOC7/UPF3B/SEH1L/XPO4/SENP2/NUP58/DDX19B/NUP188/XPO5/NUP107/DDX19A/UPF1/NUP205/NUP43/NUP155/NUP85/NUP35/THOC5/AAAS	3.39526867238237
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	64/2701	157/9376	1.41505505156146	THBS1/NFATC1/ATP11B/ATP11C/SPHK1/MFGE8/BCAR1/ATP11A/DUSP5/DOCK1/MAPKAPK2/TMEM30A/ITGAV/DUSP16/HIF1A/NFATC2/PTPN11/PBX1/MAPK3/CPT1A/ITGB3/CAMK2D/GAS6/XKR6/PTGS2/STAB2/ATP2A2/RAB14/ANO6/SIRPA/TGFBRAP1/MAPK1/ADAM10/NR1H2/ADAM17/CASP7/CREB1/PPARD/VPS39/DUSP2/ODC1/RAB7A/RAB5A/PTK2/CX3CL1/MAP2K1/PPARG/SCARF1/PANX1/CASP3/RAC1/ANO5/ARG2/RAB17/PLA2G6/DUSP4/MAPK12/GULP1/SLC16A1/MAPK11/ELMO1/SPHK2/JAK2/RAB7B	3.33607586242153
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	36/2701	78/9376	1.60214165693618	SHC1/DNM3/SEPTIN6/BCAR1/GAB1/DOCK1/PXN/ARPC5L/CTNNA1/CTTN/PIK3CB/ITGA5/SEPTIN9/PIK3R3/CLTB/ILK/WASF1/ARHGAP10/PTK2/CD2AP/VCL/MET/DNM2/SEPTIN11/SEPTIN8/MAD2L2/CBL/RAC1/ACTG1/ITGB1/CLTCL1/SEPTIN1/ELMO1/SHC2/ACTR3B/ACTR3C	3.39682754851563
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	30/2701	62/9376	1.67966464033632	FOXO1/INSR/PRKAG2/AKT3/CRYAB/HSPA1A/HSPA1B/HSPA8/SOD2/PIK3CB/PRKAA2/ADCY4/HSPA6/PIK3R3/HDAC1/RPS6KB1/ATG5/PRKAA1/RPTOR/HRAS/MTOR/PRKAG1/FOXO3/AKT2/ADCY6/IGF1R/IRS2/AKT1S1/HSPA1L/ADCY1	3.41542457909142
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	33/2701	70/9376	1.63647326387052	SNTB2/CD55/HLA-DRB1/HLA-B/HLA-A/HLA-F/HLA-E/HLA-C/HLA-DPA1/HLA-DPB1/HLA-DRB5/ABL2/HLA-DQB1/EIF4G1/HLA-DMA/CD40/SGCD/HLA-DRA/CYCS/HLA-DQA1/ABL1/HLA-DQA2/FYN/HLA-DOA/CXADR/CASP3/RAC1/ACTG1/NOS1/ICAM1/DMD/SNTA1/HLA-DQB2	3.3999298488571
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	69/2701	173/9376	1.38450969775699	DNAJB1/HLA-DRB1/AKT3/RAB11A/JAK1/CCND3/HLA-DPA1/HLA-DPB1/HLA-DRB5/IKBKB/CALCOCO2/HLA-DQB1/TNFRSF10B/PIK3CB/NUP98/FDPS/TBK1/MAPK3/NXT1/PIK3R3/NFKBIA/HLA-DMA/STAT1/EIF2S1/TRIM25/RELA/HLA-DRA/ADAR/NFKBIB/IRF3/KPNA1/CYCS/TNFRSF1A/DNAJC3/MAPK1/PML/HNRNPUL1/TRAF3/RAB11B/MX1/CIITA/TICAM1/IFNAR1/EIF2AK2/HLA-DQA1/OAS1/HLA-DQA2/TNFRSF10A/MAP2K1/IRAK4/SOCS3/IL33/CREBBP/IFIH1/HLA-DOA/EP300/CASP3/IRF7/OAS2/ACTG1/IL6/AKT2/ICAM1/TYK2/BCL2L2-PABPN1/IFNG/HLA-DQB2/TLR3/JAK2	3.24704220403452
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	45/2701	104/9376	1.50200780337767	AGPAT4/PLA1A/SGMS2/LPIN2/PLA2G4C/GPAT3/AGPAT5/LPGAT1/LPIN1/MBOAT7/CHKA/SELENOI/CDS2/GPCPD1/CDIPT/DGKE/CHPT1/GNPAT/MBOAT1/PLPP1/AGPAT3/PISD/PTDSS1/PLA2G12A/DGKH/LPCAT3/PLPP5/GPAT4/PEMT/CRLS1/PLA2G6/PLD2/GDPD5/DGKA/ADPRM/DGKD/DGKI/PLA2G4A/PCYT2/DGKQ/LPCAT4/PNPLA7/LCAT/ACHE/PLPP2	3.27463365875432
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	30/2701	63/9376	1.65300329683891	POLE4/RFC1/POLR2L/POLR2H/POLR2I/POLD4/POLR2J3/RAD23B/CUL4A/ERCC1/POLR2B/XPC/CETN2/CCNH/GTF2H1/POLD2/RFC2/CDK7/CUL4B/ERCC6/POLD3/DDB2/RPA1/POLR2D/UVSSA/POLR2M/GTF2H4/POLE2/GTF2H2/RPA4	3.30798203593604
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	47/2701	110/9376	1.48319477634546	SMAD1/TGFBR2/THBS1/PPP2R1B/BMP2/NBL1/MYC/FBN1/TGFB2/SMAD3/INHBB/MAPK3/SIN3A/ZFYVE9/CUL1/SKI/SMAD2/SMURF1/HDAC1/LRRC32/NCOR1/MAPK1/SMAD4/ROCK1/PPP2CA/RPS6KB1/SKIL/PPP2CB/ACVR1B/THSD4/BMP6/SP1/SMURF2/TGIF1/CREBBP/LEMD3/NEO1/EP300/TF/BMPR2/TGFB3/INHBA/GDF7/CHRD/IFNG/RGMB/ID4	3.24261002124539
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	37/2701	83/9376	1.54745007426968	FAR2/ACSL4/ACSL5/SOD2/GSTK1/FAR1/PHYH/MPV17/ECI2/PMVK/GNPAT/PRDX1/PXMP2/ABCD4/HACL1/SLC25A17/PEX14/CRAT/PEX26/PEX11B/PEX10/EPHX2/PEX5/DHRS4/PEX16/PEX19/PECR/PEX6/MPV17L2/ACOX3/NUDT7/PEX7/EHHADH/ACOT8/PAOX/DDO/PEX11A	3.18660249551924
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	38/2701	86/9376	1.53383329171797	SHC1/CDKN1A/CBLB/AKT3/GAB1/MYC/ABL2/PIK3CB/MAPK3/PIK3R3/CAMK2D/PLCG2/NCK1/BRAF/STAT5B/PAK3/PAK2/STAT5A/MAPK1/RPS6KB1/PTK2/ABL1/EGFR/MAP2K1/MAPK8/SOS2/HRAS/GSK3B/MTOR/MAP2K4/CBL/PLCG1/ARAF/HBEGF/AKT2/ELK1/MAP2K7/SHC2	3.16351077724868
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	29/2701	62/9376	1.62367581899177	TLE1/CTBP2/SPEN/DTX1/SNW1/KAT2B/HES1/NUMB/APH1B/HDAC1/PSEN1/ADAM17/NOTCH1/PSENEN/NCOR2/NUMBL/TLE2/CREBBP/ITCH/EP300/RFNG/PSEN2/MAML1/DTX3/KAT2A/DTX4/DVL1/ATXN1L/DLL1	3.13407171000603
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	78/2701	204/9376	1.3272644118736	CDKN1A/THBS1/PLCE1/AKT3/HSPG2/FLNA/FZD6/GAB1/MYC/VAV3/HOXD10/RRAS2/STAT3/PXN/TGFB2/CTTN/RDX/SDC4/ITGAV/PIK3CB/HIF1A/ITGA5/PTPN11/TIAM1/FGFR1/MAPK3/PIK3R3/ITGB3/MSN/CAMK2D/ROCK2/PLCG2/PPP1R12B/SMAD2/BRAF/MMP2/VEGFA/PPP1R12C/IQGAP1/TIMP3/FZD8/MAPK1/ROCK1/WNT5A/EIF4B/RPS6KB1/DDX5/FGF2/PTK2/ARHGEF12/EGFR/MAP2K1/MET/SOS2/ITPR3/HRAS/MTOR/MDM2/WNT5B/CBL/PLCG1/CASP3/RAC1/ARHGEF1/ARAF/ACTG1/MRAS/ITGB1/MAPK12/HBEGF/AKT2/HPSE/ELK1/MAPK11/WNT9A/IGF1R/WNT2B/PTCH1	3.00610493666448
NA	NA	hsa04517	IgSF CAM signaling	109/2701	299/9376	1.26545971453655	ACTN1/FOXO1/APP/TUBB6/TRIO/MAGI1/TJP2/NRP2/AKT3/MYL9/PARD6G/SPTBN1/NECTIN3/BCAR1/MYH11/EPB41L2/MAP2/ROBO4/VAV3/RAP1B/MYH9/PXN/ARPC5L/TUBB4B/PARD3/RDX/CABLES1/MYH10/PIK3CB/PVR/ITGA5/TUBA1A/PTPN11/FGFR1/MAPK3/SORBS1/MAGI2/MYL12A/CASK/PIK3R3/ITGB3/MSN/UNC5A/PLCG2/EPB41L3/NCK1/F11R/NECTIN2/SRGAP1/PAK3/PAK2/NTN1/MYL6B/IQGAP1/SRGAP2/MPDZ/NLGN1/MAPK1/ERC1/DYNLL1/PMP22/GIT1/PLXNA2/PTK2/ABL1/TUBA1C/UNC5B/CD2AP/VCL/MAP2K1/MAPK8/PPFIA1/GSK3B/TRAF6/PRKCI/FYN/RAP1A/NCAM1/PLXNA4/SRGAP3/TUBA4A/BAIAP2/EPB41L1/MTSS2/CXADR/PLCG1/PRKCQ/RAC1/ROBO3/MYL12B/ACTG1/ITGB1/MAPK12/AKT2/MAPK11/CLEC4M/ICAM1/PTPRF/CADM4/MYL6/ACTR3B/PPFIA3/NLGN2/TUBB3/CD2/LRFN4/ACTR3C/PPFIA2/LCK	2.96746321946949
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	39/2701	90/9376	1.50423300012341	FOXO1/CREB5/SESN3/INSR/PRKAG2/AKT3/CAMKK2/SOD2/PIK3CB/PRKAA2/ADCY4/PIK3R3/RELA/ATG101/RB1CC1/EHMT1/EIF4E/ATF2/CREB1/ULK1/RPS6KB1/ATG5/PRKAA1/RPTOR/HRAS/PPARG/MTOR/ADIPOR2/PRKAG1/ATF6B/CREB3L2/ATG13/FOXO3/AKT2/ADCY6/IGF1R/IRS2/AKT1S1/ADCY1	3.05745782840805
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	40/2701	93/9376	1.4930352358545	CDKN1A/AKT3/LAMA4/LAMA3/LAMB1/MYC/IKBKB/ITGAV/PIK3CB/ITGA6/PIK3R3/GADD45A/NFKBIA/POLK/RELA/PTGS2/MAX/BCL2/LAMB2/CYCS/ZBTB17/TRAF3/E2F3/PTK2/COL4A5/TRAF6/CKS1B/TRAF5/BIRC3/GADD45B/CASP3/LAMC1/DDB2/ITGB1/FHIT/TRAF2/AKT2/GADD45G/CCNE2/TRAF1	3.03946783976606
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	31/2701	68/9376	1.58250756800314	AKT3/TCF7L1/JUP/MYC/ZBTB16/IKBKB/STAT3/PIK3CB/MAPK3/TCF7L2/PIK3R3/RELA/BRAF/STAT5B/DUSP6/STAT5A/MAPK1/PML/RARA/PER2/PPARD/RPS6KB1/MAP2K1/SOS2/HRAS/MTOR/RUNX1T1/ARAF/AKT2/LEF1/PIM2	3.06655060879236
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	22/2701	44/9376	1.73565346168086	CREB5/RAB11A/DYNC1I2/DYNC1H1/DYNC1LI2/DCTN2/VAMP2/DYNC1I1/DYNC1LI1/DYNC2H1/STX4/ARHGDIA/RAB11B/DYNLL1/CREB1/RAB5A/DCTN1/DYNC2LI1/CREB3L2/AVPR2/GNAS/ADCY6	3.11124743362239
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	42/2701	99/9376	1.47267566445649	RALGDS/AKT3/PDGFD/WASF3/PIK3CB/PDGFA/SLC22A4/HIF1A/PLA2G4C/MAPK3/PIK3R3/PIP5K1A/CHKA/MAPK1/GPCPD1/RPS6KB1/WASF1/DGKE/EGFR/CHPT1/MAP2K1/MAPK8/SOS2/HRAS/PLPP1/MTOR/SP1/PIP5K1C/DGKH/PLCG1/RAC1/PDGFB/PLD2/AKT2/SLC44A3/DGKA/DGKD/DGKI/PLA2G4A/DGKQ/SLC22A5/PLPP2	3.0074565225189
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	51/2701	125/9376	1.41629322473158	SPHK1/AKT3/PPP2R1B/CERS6/PRKCZ/PRKCE/PPP2R5C/PIK3CB/PLCB4/SGMS2/MAPK3/PPP2R3A/PIK3R3/ROCK2/RELA/PPP2R5A/BCL2/BDKRB2/PPP2R5E/ORMDL2/TNFRSF1A/PPP2R2D/NOS3/ACER2/MAPK1/GNAI3/GNA12/SPTLC1/ROCK1/PPP2CA/CERS5/PPP2R3C/MAP2K1/MAPK8/PPP2CB/HRAS/FYN/CERS4/NSMAF/RAC1/PPP2R5B/PPP2R5D/GNAQ/MAPK12/PLD2/TRAF2/AKT2/MAPK11/PLCB1/SPHK2/S1PR3	2.98045318085328
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	16/2701	29/9376	1.91520381978578	WWTR1/FRMD6/TEAD4/TEAD1/LATS2/TEAD2/YAP1/CSNK1E/RASSF1/STK3/SAV1/LIMD1/FAT4/NF2/WTIP/DCHS1	3.13980731514883
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	87/2701	233/9376	1.29615322889472	PDLIM1/LMNA/SNTB2/ACTG2/DES/THBS1/PDLIM3/SYNE1/MYL9/CSRP1/SPTBN1/FLNC/ATP1A1/ITGA9/ITGB4/HSPG2/DSP/PDLIM4/JUP/MYH11/TPM4/MYH9/SUN2/PDLIM2/DIAPH1/ITGA1/FBN1/TPM2/PLEC/SDC4/ITGAV/MYH10/TMOD3/ITGA6/FHL3/FHL1/SYNE2/DIAPH2/ITGA5/TMOD2/ZYX/TMOD1/DAAM1/ITGB3/SUN1/SGCD/TLN1/ENO1/TMEM43/TTN/LMOD1/COL4A5/FHL2/VCL/ITGA8/TPM3/THBS3/EMD/PDLIM7/SYNPO2/FMNL3/INF2/SYNE3/OBSCN/ITGA10/COL27A1/THBS2/ACTG1/NID1/ITGB1/AGRN/VIM/CAPN3/COL6A3/ANKRD1/ITGB8/ITGA11/TRIM54/COL5A3/ACTN2/DMD/FBLN2/SNTA1/ITGA7/ENO2/MYOM3/LDB3	2.91187258715582
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	59/2701	149/9376	1.37454435220363	SHC1/RALGDS/INSR/SPHK1/AKT3/RAPGEF4/DNM3/PDGFD/GAB1/RRAS2/AGPAT4/PIK3CB/PDGFA/PLCB4/PLA2G4C/PTPN11/ADCY4/MAPK3/RALB/PIK3R3/PIP5K1A/PLCG2/AGPAT5/PTK2B/MAPK1/CYTH2/GNA12/DGKE/RALA/EGFR/MAP2K1/SOS2/HRAS/PLPP1/DNM2/AGPAT3/MTOR/FYN/PIP5K1C/DGKH/PLCG1/CYTH1/PDGFB/MRAS/AVPR2/PLD2/AKT2/PLCB1/GNAS/ADCY6/DGKA/DGKD/SHC2/DGKI/PLA2G4A/DGKQ/SPHK2/PLPP2/ADCY1	2.93149003249423
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	66/2701	170/9376	1.34768386436396	ACTN1/MAGI1/TJP2/YBX3/PRKAG2/MYL9/PARD6G/PPP2R1B/DLG2/HSPA4/RAB13/MYH11/MYH9/RAB8B/PRKCZ/ARPC5L/CLDN5/PARD3/CTTN/RDX/PRKCE/MYH10/ARHGAP17/PRKAA2/SYNPO/TUBA1A/TIAM1/DLG1/MYL12A/NEDD4/MSN/ROCK2/F11R/MYL6B/PATJ/PPP2R2D/MPDZ/MAP3K1/ROCK1/PPP2CA/RAB8A/AMOTL1/TUBA1C/AMOT/PRKAA1/MAPK8/PPP2CB/PRKCI/RAP1A/SYMPK/PRKAG1/TUBA4A/NEDD4L/RAC1/MYL12B/ACTG1/ITGB1/NF2/MICALL2/TJAP1/LLGL2/MAP2K7/MYL6/ACTR3B/ACTR3C/CLDN12	2.91001888017997
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	55/2701	138/9376	1.38349188974561	FOXO1/SHC1/INSR/CBLB/PRKAG2/AKT3/PRKAR1B/SOCS2/IKBKB/PRKCZ/PIK3CB/PRKAA2/HK1/FLOT1/MAPK3/SORBS1/ACACB/PIK3R3/BRAF/PPP1R3B/EIF4E/MAPK1/INPP5A/PTPN1/RHOQ/RPS6KB1/PRKAA1/RPTOR/SOCS4/MAP2K1/MAPK8/SOS2/HRAS/SOCS3/GSK3B/ACACA/PYGB/MTOR/PRKCI/GYS1/MKNK2/PRKAG1/CBL/G6PC3/CALML4/ARAF/TRIP10/AKT2/ELK1/PPP1R3E/IRS2/PTPRF/SHC2/HK2/PPP1R3C	2.88688207046483
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	56/2701	142/9376	1.36896611062152	PLAT/AKT3/TXN/SQSTM1/IKBKB/PRKCZ/THBD/HSP90AB1/SDC4/ITGAV/PIK3CB/PDGFA/PRKAA2/ASS1/HSP90AA1/MGST2/PIK3R3/VCAM1/ITGB3/RELA/SELE/MGST3/IL1R1/NFE2L2/MMP2/SUMO3/VEGFA/BCL2/GSTO1/TNFRSF1A/NOS3/PTK2/PRKAA1/MAPK8/GSTM3/HMOX1/MAP2K4/MGST1/GSTT2B/MAPK7/CALML4/RAC1/PDGFB/ACTG1/MAPK12/AKT2/MAPK11/ICAM1/BMPR2/MAP2K7/KLF2/GSTO2/IFNG/MAP2K6/EDN1/GSTM2	2.81811045136012
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	27/2701	59/9376	1.58856418526723	DPYD/UPP1/UCK2/NT5E/NME1/ENTPD4/NT5C2/NME7/CDA/NT5C3A/DHODH/CMPK1/DCTPP1/NME2/ASMTL/DCTD/NT5C3B/CTPS1/CTPS2/CDADC1/RRM1/AK9/UCKL1/ENTPD5/ENTPD1/UCK1/NT5M	2.88472278384484
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	79/2701	212/9376	1.29355305163007	ANGPT2/FLT4/THBS1/MAGI1/RALGDS/INSR/PLCE1/AKT3/EFNA5/PARD6G/RASGRP3/RAPGEF4/PDGFD/BCAR1/PRKD2/VAV3/RAP1B/PRKD1/PRKCZ/DOCK4/PARD3/PIK3CB/PDGFA/PLCB4/ARAP3/ADCY4/TIAM1/FGFR1/MAPK3/RALB/MAGI2/PIK3R3/ITGB3/BRAF/EFNA1/TLN1/VEGFA/MAPK1/GNAI3/PGF/F2RL3/PRKD3/EPHA2/MAP2K3/FGF2/RALA/EGFR/MAP2K1/VEGFC/MET/HRAS/CSF1/CNR1/RAPGEF5/PRKCI/RAP1A/ENAH/SIPA1L1/PLCG1/CALML4/RAC1/GNAQ/PDGFB/ACTG1/MRAS/ITGB1/MAPK12/AKT2/MAPK11/PLCB1/GNAS/ADCY6/IGF1R/FLT1/NGF/MAP2K6/GNAO1/LAT/ADCY1	2.7500100750065
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	49/2701	122/9376	1.39421343643217	FOXO1/PLCE1/AKT3/ATP1A1/PFKP/MYC/ITGAV/PIK3CB/PLCB4/HIF1A/MAPK3/SIN3A/PIK3R3/ITGB3/STAT1/KAT2B/PLCG2/ATP2A2/HDAC1/NCOR1/MAPK1/NOTCH1/MED27/MED13/MAP2K1/HRAS/GSK3B/MTOR/CREBBP/RCAN2/MDM2/HDAC3/MED17/EP300/PLCG1/MED14/RCAN1/ACTG1/AKT2/THRB/FXYD2/PLCB1/KAT2A/MED13L/PFKM/MED24/PLN/PLCD4/PLCD1	2.78784668063545
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	75/2701	200/9376	1.30174009626064	MYO1D/TUBB6/MYO5C/CASP4/MYH11/MYH9/IKBKB/WASF3/ARPC5L/TUBB4B/CLDN5/TNFRSF10B/CTTN/MYH10/TUBA1A/PTPN11/MAPK3/MYO1E/MYO6/NCKAP1/NFKBIA/ROCK2/SEC24D/NCK1/RELA/MYO5A/IL1R1/PAK3/PAK2/NFKBIB/CYCS/TNFRSF1A/RIPK1/MYO1C/MAPK1/BRK1/GAPDH/CYTH2/GNA12/CASP7/MYO1B/SEC24B/ROCK1/WASF1/ABL1/TUBA1C/TNFRSF10A/ARHGEF12/MAPK8/IRAK4/SEC24A/BAIAP2L1/TRAF6/FYN/WIPF2/ABCF2/TUBA4A/BAIAP2/SEC24C/CASP3/RAC1/ARHGEF1/ARHGEF11/CYTH1/ACTG1/IL6/ITGB1/MAPK12/TRAF2/MAPK11/WIPF3/ACTR3B/TUBB3/ACTR3C/CLDN12	2.74374417271389
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	54/2701	137/9376	1.36825236395279	LMNA/AKT3/CAPN2/MCL1/IKBKB/DDIT3/TNFRSF10B/PIK3CB/TUBA1A/MAPK3/ERN1/PIK3R3/GADD45A/NFKBIA/EIF2S1/IL3RA/RELA/CTSH/BCL2/CYCS/CTSF/TNFRSF1A/RIPK1/MAPK1/PARP4/DAB2IP/MAP3K14/CASP7/BCL2L11/TUBA1C/TNFRSF10A/MAP2K1/MAPK8/ITPR3/HRAS/CASP10/CFLAR/TUBA4A/DAXX/HTRA2/BIRC3/GADD45B/CASP3/EIF2AK3/PTPN13/ACTG1/TRAF2/AKT2/GADD45G/CASP6/BBC3/NGF/TRAF1/NTRK1	2.76194889666919
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	164/2701	480/9376	1.18602986548192	APP/TUBB6/RYR3/COX7A1/MAP1LC3A/CAPN2/OPTN/HIP1/UBC/SQSTM1/PPP3CA/FZD6/MCU/IFT57/ATXN3/DDIT3/TUBB4B/PPP3CC/SNCA/NDUFS7/KLC1/PLCB4/ATF6/DCTN2/TUBA1A/UBE2L6/TBK1/VCP/MAPK3/UBE2G1/PSMB2/UBE2G2/MAP1LC3B/ERN1/DNAH14/BECN1/CAMK2D/EIF2S1/PSMD13/NDUFV1/FUS/LRP5/PSMB3/RELA/ATG101/BRAF/CSNK1E/ATP5MC1/DCTN3/PTGS2/UBE2J1/ATP2A2/BCL2/PINK1/CYCS/RB1CC1/PRKN/PSMB7/TNFRSF1A/PARK7/CSNK2B/COX6A1/NDUFC1/NDUFB1/PSMD11/FZD8/PSEN1/ATG2B/MAPK1/NDUFA10/SNCAIP/SEM1/PSMC5/PSMD2/CASP7/PSMC3/PSMD14/NDUFS4/TARDBP/WNT5A/ATXN2L/ULK1/COX7A2/RAB8A/PSMD7/MAP2K3/CSNK1A1/NDUFB2/NDUFS3/RAB5A/TUBA1C/CSNK2A1/CHMP2B/PPP3CB/PSMA7/DCTN1/ACTR1A/DERL1/UBA1/MAP2K1/ATXN2/MAPK8/APC/ITPR3/PIK3C3/HRAS/SDHA/GSK3B/CSF1/MTOR/CSNK2A2/DKK1/TUBA4A/HSPA5/ALS2/WNT5B/DAXX/ZFYVE1/HTRA2/ACTR1B/WDR41/PLCG1/MFN1/AMBRA1/MFN2/CASP3/CALML4/RAC1/DNAL1/GNAQ/AXIN1/PSEN2/EIF2AK3/DNAH6/ARAF/PIK3R4/NOX4/GRIA1/CACNA1C/SIGMAR1/ATG13/IL6/ULK2/NOS1/MAPK12/TRAF2/LRRK2/MAPK11/WNT9A/PLCB1/ATP5F1E/MAP2K7/PPIF/WNT2B/MAP3K10/DVL1/ATXN1L/DNAL4/STX1A/TUBB3/DNAH1/KLC2/MAP2K6/CHRM5	2.66151059200632
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	47/2701	117/9376	1.39445662733334	BAZ1A/CDK2AP1/BCL7C/INO80C/GATAD2A/INO80D/MBD2/SMARCA2/SMARCE1/ZNHIT1/SMARCC1/BAZ2A/MORF4L2/GATAD2B/HDAC1/EP400/MORF4L1/ARID1B/SMARCA4/BAZ1B/SMARCC2/RBBP4/SMARCA5/INO80/BICRAL/SMARCA1/CDK2AP2/BPTF/MTA3/RSF1/SRCAP/RUVBL2/MEAF6/SMARCD1/ARID2/TRRAP/ACTG1/INO80E/ING3/BAZ2B/PHF10/NFRKB/KAT5/MTA2/SS18L1/INO80B/ACTR8	2.7310675445718
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	60/2701	156/9376	1.33511804744681	CDKN1A/AKT3/PPP2R1B/YWHAG/JAK1/MYC/IKBKB/STAT3/LDLR/CLDN5/YWHAQ/PIK3CB/TBK1/MAPK3/PIK3R3/NFKBIA/STAT1/EIF2S1/RELA/BRAF/YWHAH/IRF3/CYCS/TNFRSF1A/PPP2R2D/RIPK1/MAPK1/TRAF3/YWHAZ/MX1/TICAM1/PPP2CA/IFNAR1/E2F3/EIF2AK2/OAS1/EGFR/MAP2K1/PPP2CB/SOS2/HRAS/SOCS3/GSK3B/YWHAE/PIAS1/YWHAB/TRAF6/CFLAR/PSME3/CASP3/IRF7/OAS2/ARAF/TRAF2/AKT2/CD81/TYK2/IFNG/CLDN12/TLR3	2.68483098263616
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	42/2701	103/9376	1.41548437651643	TGFBR2/AKT3/SERPINE1/PPP2R1B/IKBKB/TGFB2/PIK3CB/PLCB4/MAPK3/PIK3R3/NFKBIA/RELA/SMAD2/BDKRB2/TNFRSF1A/PPP2R2D/MAPK1/GNA14/GNAI3/TICAM1/PPP2CA/MAPK8/PPP2CB/IRAK4/MAP2K4/TRAF6/CFLAR/GNA11/C3/GNAL/GNAQ/IL6/MAPK12/AKT2/MAPK11/PLCB1/GNAS/TGFB3/IFNG/CD3E/GNAO1/ADCY1	2.69702812500132
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	43/2701	106/9376	1.40817167645806	FOXO1/CREB5/PLAT/CDKN1A/AKT3/TCF7L1/ERG/PDGFD/AR/IKBKB/HSP90AB1/PIK3CB/PDGFA/FGFR1/MAPK3/TCF7L2/HSP90AA1/PIK3R3/NFKBIA/RELA/BRAF/ZEB1/BCL2/MAPK1/CREB1/E2F3/EGFR/MAP2K1/SOS2/HRAS/GSK3B/MTOR/CREBBP/MDM2/EP300/CREB3L2/ARAF/PDGFB/AKT2/IGF1R/NKX3-1/LEF1/CCNE2	2.68830305776717
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	51/2701	130/9376	1.36182040839575	GNG12/TGFBR2/SHC1/CREB5/AKT3/ACTA2/PRKCZ/GNB5/PIK3CB/PLCB4/ADCY4/MAPK3/PIK3R3/NFKBIA/GNB1/RELA/SMAD2/MMP2/VEGFA/ARRB1/NOS3/MAPK1/GNAI3/ATF2/CREB1/EDNRB/COL4A5/EGFR/MAP2K1/MAPK8/VEGFC/SOS2/HRAS/MAP2K4/ATF6B/GNG11/CREB3L2/RXFP1/NOS1/MAPK12/AKT2/MAPK11/PLCB1/GNAS/ADCY6/MAP2K7/SHC2/GNGT2/GNAO1/EDN1/ADCY1	2.64247012725991
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	59/2701	155/9376	1.32133618373123	TUBB6/THBS1/HLA-DRB1/HLA-B/HLA-A/HLA-F/HLA-E/HLA-C/HLA-DPA1/EEA1/HLA-DPB1/HLA-DRB5/DYNC1I2/VAMP3/TUBB4B/HLA-DQB1/PLA2R1/ITGAV/DYNC1H1/DYNC1LI2/ITGA5/TUBA1A/STX12/TAP1/ITGB3/HLA-DMA/DYNC1I1/HLA-DRA/C1R/DYNC1LI1/COLEC12/TAP2/DYNC2H1/RAB7A/HLA-DQA1/RAB5A/HLA-DQA2/TUBA1C/PIK3C3/THBS3/STX18/TUBA4A/HGS/HLA-DOA/C3/RAC1/RILP/ATP6V0A2/THBS2/ACTG1/ITGB1/NOS1/CLEC4M/SEC61A2/MSR1/TUBB3/ATP6V1E2/HLA-DQB2/RAB7B	2.56601248395867
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	74/2701	201/9376	1.27799359367546	SMAD1/FOXO1/TGFBR2/PLAT/CDKN1A/ERG/JMJD1C/JUP/MLF1/MYC/ZBTB16/DDIT3/NUPR1/ETV6/PDGFA/TAF15/PBX1/TSPAN7/SIN3A/KMT2A/LMO2/GADD45A/ELK4/FUS/CDKN2C/CD40/POLK/RELA/BCL6/DUSP6/ZEB1/MAX/FLI1/HDAC1/ZBTB17/ETV1/NCOR1/PML/RARA/PER2/CCNT2/DDX5/REL/PTK2/PBX3/MET/TFE3/PPARG/SP1/AFF1/SLC45A3/KDM6A/RUNX1T1/CCNT1/MDM2/BIRC3/ATF1/GADD45B/DOT1L/CDK14/DDB2/IL6/SUPT3H/NSD2/GADD45G/IGF1R/FLT1/ASPSCR1/SS18L1/WT1/MYCN/TRAF1/NTRK1/EYA1	2.53426528937724
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	25/2701	56/9376	1.54969059078648	BOC/CUL1/CSNK1E/SMURF1/BCL2/SPOP/FBXW11/ARRB1/MOSMO/CSNK1D/HHAT/CUL3/CSNK1G1/CSNK1A1/MGRN1/CSNK1G3/GSK3B/EVC2/SMURF2/SPOPL/IQCE/KIF3A/GPR161/EVC/PTCH1	2.62437961494996
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	18/2701	37/9376	1.68874390866246	UAP1/HK1/GMDS/GPI/PGM2/PGM1/NANS/PMM2/UGDH/UGP2/CMAS/GNE/GNPNAT1/GALK2/GFPT2/GALK1/HK2/NANP	2.67011975868747
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	42/2701	105/9376	1.38852276934469	NFATC1/CBLB/AKT3/RELB/PPP3CA/RRAS2/IKBKB/MAPKAPK2/PPP3CC/IRF1/PIK3CB/BCL10/NFATC2/BCL3/PTPN11/MAPK3/PLK3/PIK3R3/NFKBIA/STAT1/PLCG2/RELA/PTGS2/MALT1/MAPK1/MAP3K14/NFKB2/ARHGEF12/PPP3CB/MAPK8/ITPR3/HRAS/EGR3/MDM2/CALML4/MRAS/IL6/MAPK12/AKT2/MAPK11/CLEC4M/IL17D	2.54665509185444
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	78/2701	214/9376	1.26524271038418	GNG12/NFATC1/HLA-B/HLA-A/HLA-F/AKT3/HLA-E/HLA-C/LIMK2/PPP3CA/IKBKB/PXN/TAPBP/PPP3CC/GNB5/PIK3CB/NFATC2/TBK1/MAPK3/ELOC/TAP1/PIK3R3/NFKBIA/CUL1/GNB1/PLCG2/RELA/CUL4A/PTK2B/WEE1/PAK3/PAK2/IRF3/TAP2/BCL2/CYCS/FBXW11/TNFRSF1A/RIPK1/DCAF1/MAPK1/GNAI3/CFL2/RPS6KB1/MAP2K3/PTK2/PPP3CB/ATR/MAP2K1/MAPK8/IRAK4/CUL5/ITPR3/HRAS/MTOR/TRAF6/GNA11/TRAF5/GNG11/CUL4B/PLCG1/CGAS/CASP3/CALML4/RAC1/GNAQ/AP1G2/TAPBPL/MAPK12/TRAF2/AKT2/MAPK11/MAP2K7/CXCR4/GNGT2/MAP2K6/CD3E/GNAO1	2.4967640090649
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	75/2701	205/9376	1.26999033781526	ACTN1/CREB5/CDKN1A/GSN/HLA-B/HLA-A/HLA-F/HLA-E/YWHAG/HLA-C/JAK1/CCND3/PKM/MAPKAPK2/STAT3/PXN/YWHAQ/HDAC4/PIK3CB/DLG1/SNW1/MAPK3/HDAC7/PIK3R3/NFKBIA/KAT2B/SP100/RELA/YWHAH/STAT5B/IRF3/HDAC1/STAT5A/MAPK1/TRAF3/YWHAZ/TBPL1/ATF2/CREB1/LTBR/NFKB2/EIF2AK2/REL/POLB/GTF2H1/HRAS/RBL2/YWHAE/UBR4/YWHAB/EGR3/CREBBP/TRAF5/ATF6B/MDM2/GTF2A1/C3/HDAC3/GTF2E2/EP300/CREB3L2/CASP3/IRF7/RAC1/TRAF2/DDX3X/HDAC5/KAT2A/HDAC6/HDAC10/GTF2H4/TBP/CCNE2/GTF2H2/TRAF1	2.48621739874245
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	69/2701	187/9376	1.28085656530459	MAP1LC3A/JAK1/CASP4/TXN/MCU/GBP2/GABARAPL1/IKBKB/HSP90AB1/TP53BP1/PLCB4/NOD1/TBK1/MAPK3/HSP90AA1/TNFAIP3/MAP1LC3B/GBP1/NFKBIA/RBCK1/STAT1/ERBIN/RELA/NFKBIB/IRF3/BCL2/GABARAPL2/RIPK1/MAPK1/GSDMD/TRAF3/CXCL2/TICAM1/IFNAR1/CARD8/OAS1/TRIP6/SUGT1/ATG5/DNM1L/TRPM7/MAPK8/IRAK4/GBP3/ITPR3/ATG12/YWHAE/CXCL1/TRAF6/PANX1/TRAF5/CARD6/BIRC3/DHX33/MFN1/RIPK2/MFN2/IRF7/OAS2/IL6/GBP4/MAPK12/TRAF2/MAPK11/PLCB1/CXCL3/TYK2/RNF31/AIM2	2.46770677358491
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	59/2701	158/9376	1.29624752201482	GRB10/INSR/RPS6KA2/AKT3/FZD6/RPS6KA3/IKBKB/RNF152/PRR5L/CLIP1/PIK3CB/PRKAA2/FNIP2/LPIN2/MAPK3/PIK3R3/FNIP1/LRP5/BRAF/LPIN1/TNFRSF1A/STRADA/FZD8/EIF4E/MAPK1/WNT5A/CAB39/ULK1/EIF4B/RPS6KB1/SLC3A2/DDIT4/RRAGC/PRR5/SLC7A5/PRKAA1/RPTOR/MAP2K1/SOS2/HRAS/GSK3B/MAPKAP1/MTOR/SEH1L/FLCN/WNT5B/WDR59/CAB39L/ULK2/RRAGB/DEPTOR/AKT2/WNT9A/IGF1R/RPS6KA6/WNT2B/AKT1S1/DVL1/ATP6V1E2	2.38884082894726
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	11/2701	20/9376	1.90921880784894	CYB5R3/UAP1/GMDS/CYB5RL/NANS/UGDH/CYB5R1/UGP2/CMAS/GNE/NANP	2.58917018514768
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	53/2701	140/9376	1.31413762098694	GNG12/PLAT/PRKAG2/SPHK1/RYR3/AKT3/SERPINE1/CCN2/MAP1LC3A/ACTA2/RRAS2/SMAD3/GNB5/PRKCE/HDAC4/PRKAA2/PLCB4/ADCY4/MAPK3/MAP1LC3B/BECN1/GNB1/SMAD2/NOS3/MAPK1/SMAD4/GNAI3/RPS6KB1/MEF2D/PRKAA1/MAP2K1/ITPR3/PIK3C3/HRAS/NRF1/MTOR/PRKAG1/GNG11/CALML4/GNAQ/PIK3R4/MRAS/NOS1/AKT2/HDAC5/PLCB1/ADCY6/KLF2/MEF2B/GNGT2/SPHK2/ADCY10/ADCY1	2.38212365311911
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	51/2701	134/9376	1.32116905292125	CALCRL/ACTG2/RAMP3/MYL9/PRKCH/ADM/MYH11/ACTA2/MYH9/PRKG1/PRKCE/MYH10/PLCB4/PLA2G4C/ADCY4/MAPK3/ROCK2/PPP1R12B/BRAF/MYL6B/PPP1R12C/NPR1/MAPK1/GNA12/RAMP1/ROCK1/ARHGEF12/MAP2K1/ITPR3/PLA2G12A/RAMP2/GNA11/CALD1/PRKCQ/CALML4/GNAQ/ARHGEF1/ARAF/ARHGEF11/CACNA1C/PLA2G6/PLCB1/GNAS/ADCY6/PLA2G4A/KCNMB1/MYL6/KCNMA1/KCNMB3/EDN1/ADCY1	2.38191030543595
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	49/2701	128/9376	1.32885968159941	PDE7B/PDE2A/PNP/GUK1/NT5E/PDE8A/AK2/ADCY4/NME1/ENTPD4/ADA/NT5C2/PGM2/NME7/AK3/PGM1/NPR1/DGUOK/GART/GMPS/PDE10A/NME2/NUDT16/PRPS2/AK1/PAICS/PDE6D/PDE7A/NUDT9/PRPS1/ADK/ENPP4/IMPDH1/RRM1/AK9/GMPR2/FHIT/AK4/ADCY6/GMPR/ADPRM/ENTPD5/PPAT/ENTPD1/PRUNE1/ADCY10/AK7/NT5M/ADCY1	2.38294490609875
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	19/2701	41/9376	1.60865442789933	CDKN1A/THBS1/DAPK1/MYC/DAPK3/DAPK2/MAPK3/BRAF/MMP2/VEGFA/RASSF1/MAPK1/E2F3/EGFR/MAP2K1/HRAS/MDM2/ARAF/HBEGF	2.48443619832274
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	20/2701	44/9376	1.57786678334624	TAF15/TAF4B/TBPL1/CCNH/GTF2H1/TAF11/TAF2/TAF1/TAF3/GTF2A1/CDK7/GTF2E2/GTF2F2/TAF9B/TAF5L/GTF2H4/TBP/TAF4/TAF6L/GTF2H2	2.44393133494362
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	20/2701	44/9376	1.57786678334624	HLA-DRB1/HLA-B/HLA-A/HLA-F/HLA-E/HLA-C/HLA-DPA1/HSPD1/HLA-DPB1/HLA-DRB5/HLA-DQB1/HLA-DMA/HLA-DRA/PTPRN2/HLA-DQA1/ICA1/HLA-DQA2/HLA-DOA/IFNG/HLA-DQB2	2.44393133494362
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	54/2701	144/9376	1.30174009626064	RORA/RELN/AKT3/MCU/ATXN3/PIK3CB/PLCB4/PSMB2/ERN1/PIK3R3/BECN1/PSMD13/PSMB3/ATG101/PUM1/ATP2A2/CYCS/RB1CC1/PSMB7/PSMD11/ATG2B/SEM1/PSMC5/TBPL1/PSMD2/PSMC3/PSMD14/ATXN2L/ULK1/PSMD7/PSMA7/ATXN2/MAPK8/ITPR3/PIK3C3/MTOR/SP1/KCND3/OPA1/AMBRA1/GNAQ/PIK3R4/GRIA1/ATG13/ULK2/TRAF2/AKT2/VLDLR/PLCB1/PPIF/KAT5/ATXN1L/TBP/BEAN1	2.32107229621743
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	17/2701	36/9376	1.63922826936526	ST6GALNAC3/GALNT18/B4GALT5/GALNT1/ST3GAL1/GALNT15/GCNT1/GALNT10/GALNT11/GALNT7/GALNT2/GCNT4/ST6GALNAC4/C1GALT1C1/GALNT4/GALNT17/ST6GALNAC2	2.44430885226561
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	52/2701	138/9376	1.30802869575949	RPS6KA2/PPP2R1B/YWHAG/PPP3CA/RPS6KA3/SLK/AR/PPP3CC/YWHAQ/PPP2R5C/ANAPC16/ADCY4/ANAPC5/MAPK3/CAMK2D/CUL1/CDC27/YWHAH/PPP2R5A/CPEB2/PPP2R5E/FBXW11/MAPK1/YWHAZ/CDC26/PPP2CA/ANAPC7/PPP3CB/MAP2K1/PPP2CB/ITPR3/YWHAE/YWHAB/CPEB3/MAD2L2/CDC16/CALML4/PPP2R5B/PPP2R5D/ANAPC4/ANAPC1/PGR/MAPK12/MAPK11/ADCY6/IGF1R/RPS6KA6/SPDYE2/CCNE2/SPDYA/ADCY1/SPDYE5	2.31880397670628
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	29/2701	70/9376	1.43811286824985	PRKAG2/AKT3/CAMKK2/ACSL4/IKBKB/STAT3/ACSL5/PRKAA2/PTPN11/LEPR/ACACB/CPT1A/NFKBIA/RELA/NFKBIB/TNFRSF1A/PRKAA1/MAPK8/SOCS3/MTOR/ADIPOR2/PRKAG1/G6PC3/PRKCQ/NFKBIE/TRAF2/AKT2/IRS2/JAK2	2.34032299938697
Human Diseases	Immune disease	hsa05330	Allograft rejection	18/2701	39/9376	1.60214165693618	HLA-DRB1/HLA-B/HLA-A/HLA-F/HLA-E/HLA-C/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/HLA-DMA/CD40/HLA-DRA/HLA-DQA1/HLA-DQA2/HLA-DOA/IFNG/HLA-DQB2	2.39689821888382
Human Diseases	Cancer: specific types	hsa05214	Glioma	31/2701	76/9376	1.41592782400281	SHC1/CDKN1A/AKT3/PIK3CB/PDGFA/MAPK3/PIK3R3/GADD45A/CAMK2D/PLCG2/POLK/BRAF/MAPK1/E2F3/EGFR/MAP2K1/SOS2/HRAS/MTOR/CAMK1/MDM2/PLCG1/GADD45B/CALML4/ARAF/DDB2/PDGFB/AKT2/GADD45G/IGF1R/SHC2	2.31582421712078
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	53/2701	142/9376	1.29562864040966	TGFBR2/NFATC1/AKT3/FOSL1/RELB/JAK1/SQSTM1/PPP3CA/IKBKB/PPP3CC/TGFB2/PIK3CB/FOSL2/NFATC2/MAPK3/JUND/PIK3R3/NFKBIA/ITGB3/STAT1/PLCG2/RELA/TNFRSF11B/IL1R1/ATP2A2/SIRPA/TNFRSF1A/MAPK1/MAP3K14/CREB1/IFNAR1/NFKB2/PPP3CB/FHL2/MAP2K1/MAPK8/ITPR3/SOCS3/PPARG/CSF1/TRAF6/FYN/RAC1/FOSB/MAPK12/TRAF2/AKT2/MAPK11/MAP2K7/TYK2/IFNG/MAP2K6/LCK	2.25796932909761
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	24/2701	56/9376	1.48770296715502	HSPD1/HSPA1A/HSPA1B/HSPA8/HSF1/HSPA6/VCP/NFKBIA/CLK1/RELA/CYCS/CXCL2/CASP7/NFKB2/BCL2L13/CXCL1/BNIP3/C3/HBS1L/CLK4/CASP3/IL6/CXCL3/HSPA1L	2.32843302506048
Human Diseases	Infectious disease: viral	hsa05162	Measles	51/2701	136/9376	1.30174009626064	CBLB/AKT3/JAK1/CCND3/HSPA1A/HSPA1B/IKBKB/STAT3/HSPA8/PIK3CB/HSPA6/TBK1/TNFAIP3/PIK3R3/NFKBIA/MSN/STAT1/EIF2S1/RELA/STAT5B/ADAR/NFKBIB/IRF3/BCL2/CYCS/CSNK2B/STAT5A/TRAF3/MX1/IFNAR1/EIF2AK2/OAS1/CSNK2A1/MAPK8/IRAK4/GSK3B/TRAF6/CSNK2A2/IFIH1/CASP3/IRF7/OAS2/IL6/AKT2/CLEC4M/TYK2/BBC3/HSPA1L/CCNE2/RAB9B/CD3E	2.25470012236137
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	29/2701	71/9376	1.41785775742943	SHC1/AKT3/SOCS2/STAT3/IRF1/PIK3CB/MAPK3/PIK3R3/STAT1/RELA/SOCS5/STAT5B/STAT5A/MAPK1/SOCS4/MAP2K1/MAPK8/SOS2/HRAS/SOCS3/GSK3B/SOCS6/FOXO3/MAPK12/AKT2/MAPK11/SHC2/ESR2/JAK2	2.24813170300789
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	38/2701	98/9376	1.34601697028312	ASAP1/GSN/SPHK1/AKT3/MARCKSL1/LIMK2/VAV3/DOCK1/WASF3/ARPC5L/PRKCE/PIK3CB/PLA2G4C/MAPK3/ASAP2/PIK3R3/PIP5K1A/PLCG2/MAPK1/CFL2/RPS6KB1/WASF1/MAP2K1/PLPP1/DNM2/ASAP3/PIP5K1C/PLCG1/RAC1/PLA2G6/PLD2/AKT2/PLA2G4A/ACTR3B/ACTR3C/SPHK2/PLPP2/LAT	2.19030980938272
Organismal Systems	Nervous system	hsa04730	Long-term depression	25/2701	60/9376	1.44637788473405	PPP2R1B/PRKG1/PLCB4/PLA2G4C/MAPK3/BRAF/MAPK1/GNAI3/GNA12/PPP2CA/MAP2K1/PPP2CB/ITPR3/HRAS/GNA11/GNAQ/ARAF/GRIA1/NOS1/PLCB1/GNAS/IGF1R/PLA2G4A/GNAZ/GNAO1	2.20640813661099
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	64/2701	178/9376	1.24811035446713	TLE1/NFATC1/FOSL1/TCF7L1/CTBP2/CCND3/PPP3CA/FZD6/MYC/PPP3CC/CELSR1/SMAD3/PLCB4/NFATC2/ANKRD6/TCF7L2/CACYBP/DAAM1/CAMK2D/CUL1/ROCK2/LRP5/TBL1X/CSNK1E/FBXW11/CSNK2B/RYK/FZD8/PSEN1/SMAD4/PPARD/WNT5A/CSNK1A1/CSNK2A1/PPP3CB/SFRP1/TBL1XR1/MAPK8/APC/GSK3B/TLE2/CSNK2A2/DKK1/CREBBP/SENP2/WNT5B/VANGL1/CHD8/EP300/NLK/INVS/RAC1/AXIN1/CCDC88C/CCN4/WNT9A/PLCB1/PORCN/WNT2B/CCAR2/PRICKLE4/DVL1/LEF1/PRICKLE3	2.12583955206706
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	31/2701	78/9376	1.37962198236171	HLA-DRB1/MARCKSL1/JAK1/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/TGFB2/MAPK3/NFKBIA/HLA-DMA/STAT1/RELA/HLA-DRA/PTGS2/NFKBIB/MAPK1/HLA-DQA1/HLA-DQA2/IRAK4/TRAF6/HLA-DOA/C3/ITGB1/MAPK12/ELK1/MAPK11/TGFB3/IFNG/HLA-DQB2/JAK2	2.14153993973721
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	21/2701	49/9376	1.48770296715502	GALNT18/GALNT1/GALNT15/GALNT10/GALNT11/GALNT7/GALNT2/POGLUT1/ST6GAL1/B3GLCT/PLOD3/ST3GAL3/RFNG/POFUT2/FUT10/C1GALT1C1/B4GALT2/XXYLT1/POMT1/GALNT4/GALNT17	2.17723218031319
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	36/2701	93/9376	1.34373171226905	PLCB4/PLA2G4C/ADCY4/MAPK3/CAMK2D/MAP3K3/PTK2B/MMP2/MAPK1/MAP3K1/MAP2K3/EGFR/MAP2K1/MAPK8/MAP3K4/SOS2/ITPR3/HRAS/MAP2K4/GNA11/MAPK7/CALML4/GNAQ/CACNA1C/MAPK12/PLD2/HBEGF/ELK1/MAPK11/PLCB1/GNAS/ADCY6/MAP2K7/PLA2G4A/MAP2K6/ADCY1	2.11904020031911
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	18/2701	41/9376	1.52398840537832	POLD4/UIMC1/SEM1/BARD1/BABAM2/RBBP8/POLD2/BABAM1/TOP3A/POLD3/MRE11/RPA1/ABRAXAS1/RAD50/BRCA1/TOP3B/PALB2/RPA4	2.13884217735225
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	29/2701	73/9376	1.37901233941767	CDKN1A/AKT3/STAT3/PIK3CB/MAPK3/PIK3R3/GADD45A/PLCG2/POLK/BRAF/STAT5B/RASSF1/STAT5A/MAPK1/E2F3/EGFR/MAP2K1/MET/SOS2/HRAS/RET/PLCG1/GADD45B/ARAF/DDB2/FOXO3/FHIT/AKT2/GADD45G	2.06788110195001
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	64/2701	181/9376	1.22742344251464	HLA-DRB1/SPHK1/AKT3/JAK1/CD74/HLA-DPA1/EEA1/PPP3CA/HSPD1/HLA-DPB1/HLA-DRB5/PPP3CC/HLA-DQB1/TGFB2/IRAK2/PLA2R1/BCL10/HSPA9/MAPK3/PLK3/HLA-DMA/CAMK2D/STAT1/RELA/HLA-DRA/BCL2/CYCS/MALT1/TNFRSF1A/MAPK1/CIITA/CREB1/RAB7A/HLA-DQA1/RAB5A/HLA-DQA2/ARHGEF12/PPP3CB/MAPK8/IRAK4/PIK3C3/NFYC/CASP10/TRAF6/CREBBP/CEBPG/HLA-DOA/C3/EP300/RIPK2/CASP3/CALML4/ATP6V0A2/IL6/MAPK12/AKT2/MAPK11/CLEC4M/TGFB3/SPHK2/IFNG/RFX5/HLA-DQB2/JAK2	1.96526420971035
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	54/2701	150/9376	1.24967049241022	TGFBR2/SHC1/CDKN1A/AKT3/TCF7L1/ABCB1/JUP/FZD6/GAB1/MYC/CTNNA1/TGFB2/SMAD3/PIK3CB/MAPK3/TCF7L2/PIK3R3/GADD45A/LRP5/POLK/SMAD2/BRAF/BCL2/FZD8/MAPK1/SMAD4/MLH1/WNT5A/E2F3/RPS6KB1/CSNK1A1/FGF2/EGFR/MAP2K1/APC/MET/SOS2/HRAS/GSK3B/MTOR/WNT5B/GADD45B/AXIN1/ARAF/DDB2/AKT2/WNT9A/GADD45G/TGFB3/WNT2B/SHC2/DVL1/LEF1/CCNE2	1.96077796385705
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	26/2701	65/9376	1.38852276934469	PNPLA2/MGLL/AGPAT4/LPIN2/GPAT3/AGPAT5/ALDH2/LPIN1/ALDH9A1/DGKE/MBOAT1/PLPP1/AGPAT3/ALDH3A2/DGKH/PLPP5/GPAT4/GLA/AGK/DGKA/TKFC/DGKD/DGAT1/DGKI/DGKQ/PLPP2	1.99938894253681
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	34/2701	89/9376	1.32611725162133	RELN/VWF/TNXB/THBS1/LAMA4/ITGA9/ITGB4/HSPG2/LAMA3/LAMB1/TNC/SV2B/ITGA1/SDC4/ITGAV/NPNT/ITGA6/ITGA5/ITGB3/LAMB2/COL4A5/ITGA8/THBS3/ITGA10/LAMC1/THBS2/ITGB1/AGRN/COL6A3/ITGB8/ITGA11/GP1BB/ITGA7/GP6	1.96631616451906
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	33/2701	86/9376	1.33201312175508	LMNA/SNTB2/DES/TCF7L1/ITGA9/ITGB4/DSP/JUP/ITGA1/CTNNA1/ITGAV/ITGA6/ITGA5/TCF7L2/ITGB3/SGCD/CACNB2/ATP2A2/ITGA8/GJA1/EMD/ITGA10/CACNA1C/ACTG1/ITGB1/NOS1/ITGB8/ITGA11/LEF1/ACTN2/DMD/SNTA1/ITGA7	1.96751889617081
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	19/2701	45/9376	1.46566292319717	HLA-DRB1/HLA-B/HLA-A/HLA-F/HLA-E/HLA-C/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/HLA-DMA/HLA-DRA/HLA-DQA1/HLA-DQA2/HLA-DOA/IL6/KLRD1/IFNG/HLA-DQB2	1.99175592406872
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	20/2701	48/9376	1.44637788473405	PCCA/OXCT1/ALDH2/HADHA/MCCC1/ALDH9A1/BCKDHB/MCCC2/ALDH3A2/AUH/ACADS/HMGCS1/ACAT1/ACADM/BCAT2/AACS/ALDH6A1/ACAD8/EHHADH/AOX1	1.97220163774609
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	22/2701	54/9376	1.41423615396218	POLK/HES1/REV3L/REV1/FANCC/ERCC1/MLH1/ATR/FANCL/USP1/TOP3A/WDR48/RPA1/POLH/RMI1/BRCA1/ATRIP/PMS2/TOP3B/FANCA/PALB2/RPA4	1.94183635075313
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	37/2701	99/9376	1.29735713297357	SHC1/CDKN1A/AKT3/PIK3CB/ADCY4/MAPK3/PIK3R3/CDKN2C/BRAF/MMP2/BCL2/NCOR1/MAPK1/NOTCH1/E2F3/RPS6KB1/PTK2/EGFR/MAP2K1/MAPK8/SOS2/HRAS/MTOR/SP1/MDM2/ARAF/MAPK12/HBEGF/AKT2/MAPK11/GNAS/ADCY6/IGF1R/SHC2/DLL1/ESR2/ADCY1	1.89197099898765
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	37/2701	99/9376	1.29735713297357	LMNA/SNTB2/DES/PRKAG2/ITGA9/ITGB4/TPM4/ITGA1/TGFB2/TPM2/ITGAV/PRKAA2/ITGA6/ITGA5/ITGB3/SGCD/CACNB2/ATP2A2/TTN/PRKAA1/ITGA8/TPM3/EMD/PRKAG1/ITGA10/CACNA1C/ACTG1/IL6/ITGB1/NOS1/ITGB8/TGFB3/ITGA11/DMD/SNTA1/ITGA7/EDN1	1.89197099898765
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	28/2701	72/9376	1.34995269241845	IKBKB/ZNFX1/TBK1/NFKBIA/TRIM25/RELA/ADAR/NFKBIB/IRF3/OTUD5/RIPK1/TRAF3/MAP3K1/ATG5/MAPK8/AZI2/ATG12/CASP10/ISG15/TRAF6/IFIH1/IRF7/MAPK12/TRAF2/DDX3X/MAPK11/TKFC/TBKBP1	1.89610783068011
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	42/2701	115/9376	1.26778165896689	CREB5/CDKN1A/PLCB4/ADCY4/FGFR1/MAPK3/JUND/WNK1/LRP5/BRAF/PTHLH/STK39/BCL2/ARRB1/MAPK1/GNAI3/GNA12/ATF2/AKAP13/CREB1/MEF2D/EGFR/MAP2K1/ITPR3/SP1/MMP17/GNA11/ATF6B/CREB3L2/MMP24/GNAQ/ARHGEF1/ARAF/ARHGEF11/PLD2/HBEGF/PLCB1/GNAS/ADCY6/MMP16/WNK3/ADCY1	1.83790517721925
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	19/2701	46/9376	1.43380068573636	PSMB9/PSMB8/PSMB2/PSME1/PSMD13/PSMB3/PSME2/PSME4/PSMB7/PSMD11/SEM1/PSMC5/PSMD2/PSMC3/PSMD14/PSMD7/PSMA7/PSME3/IFNG	1.87607684552937
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	9/2701	18/9376	1.73565346168086	TCN2/CD320/MTR/PRDX1/ABCD4/ZNF143/HCFC1/ZNF76/MMAB	1.98719419722265
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	35/2701	94/9376	1.29250789699638	FOSL1/IKBKB/HSP90AB1/ANAPC5/TBK1/MAPK3/HSP90AA1/CSF3/JUND/TNFAIP3/NFKBIA/RELA/MAPK6/PTGS2/MAPK1/TRAF3/CXCL2/ELAVL1/USP25/MAPK8/GSK3B/CXCL1/TRAF3IP2/TRAF6/TRAF5/CASP3/MAPK7/FOSB/IL6/MAPK12/TRAF2/MAPK11/CXCL3/IFNG/IL17D	1.81302183907026
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	51/2701	144/9376	1.22942120202394	FOXO1/PRKAG2/AKT3/TCF7L1/CAMKK2/IKBKB/PRKAA2/LPIN2/TBK1/TCF7L2/ACACB/CPT1A/NFKBIA/RELA/ALDH2/LPIN1/IRF3/TNFRSF1A/RIPK1/ALDH9A1/TRAF3/CXCL2/MAP3K14/TICAM1/MAP2K3/TRA2A/PRKAA1/MAPK8/IRAK4/GSK3B/CXCL1/ALDH3A2/ACACA/MAP2K4/TRAF6/ADIPOR2/PRKAG1/C3/ACADM/CASP3/NOX4/IL6/FOXO3/MAPK12/AKT2/MAPK11/MAP2K7/CXCL3/ACOX3/LEF1/MAP2K6	1.76477439618332
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	28/2701	73/9376	1.33146018978258	MAP1B/NUP153/CHMP4B/MDFIC/KAT2B/AFF4/ELL/CHMP4A/RAN/MX1/CCNT2/TSG101/PDCD6IP/SUPT5H/CPSF6/SERINC5/TNPO3/VPS4A/CCNT1/CREBBP/CPSF7/HGS/EP300/BICD2/ELL2/KAT2A/PPIA/CXCR4	1.80843785601615
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	7/2701	13/9376	1.86916526642554	XRCC6/XRCC5/DCLRE1C/MRE11/RAD50/NHEJ1/POLM	1.99475160167352
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	40/2701	110/9376	1.26229342667699	RPS6KA2/AKT3/RPS6KA3/HSP90AB1/PIK3CB/ANAPC16/ADCY4/ANAPC5/MAPK3/HSP90AA1/PIK3R3/CDC27/BRAF/CPEB2/MAPK1/GNAI3/CDC26/ANAPC7/MAP2K1/MAPK8/CPEB3/MAD2L2/CDC25B/CDC16/ANAPC4/ARAF/ANAPC1/FZR1/PGR/MAPK12/AKT2/KIF22/MAPK11/ADCY6/IGF1R/RPS6KA6/SPDYE2/SPDYA/ADCY1/SPDYE5	1.76019140828111
Organismal Systems	Immune system	hsa04611	Platelet activation	45/2701	126/9376	1.23975247262918	VWF/AKT3/RAP1B/PRKCZ/PRKG1/PIK3CB/PLCB4/PLA2G4C/ADCY4/MAPK3/SNAP23/MYL12A/PIK3R3/ITGB3/ROCK2/PLCG2/STIM1/TLN1/NOS3/MAPK1/GNAI3/F2RL3/ROCK1/ARHGEF12/ITPR3/PRKCI/FYN/RAP1A/ARHGAP35/GNAQ/ARHGEF1/MYL12B/ACTG1/ITGB1/MAPK12/AKT2/MAPK11/PLCB1/GNAS/ADCY6/PLA2G4A/GP1BB/GP6/RASGRP1/ADCY1	1.7234543968313
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	16/2701	38/9376	1.46160291509967	UAP1/HK1/GPI/PGM2/PGM1/PMM2/UGDH/UGP2/GNE/GNPNAT1/GALK2/GFPT2/HEXB/GNPDA2/GALK1/HK2	1.8136592766113
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	18/2701	44/9376	1.42008010501161	POLE4/RFC1/POLD4/APTX/TDG/PARP4/PNKP/MPG/POLB/NEIL1/POLD2/RFC2/MBD4/POLD3/XRCC1/OGG1/POLE2/MUTYH	1.77661523626486
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	27/2701	71/9376	1.32007446381361	AKT3/PFKP/PKM/MYC/LDHA/GLS/PIK3CB/HK1/HIF1A/FGFR1/MAPK3/PIK3R3/MAPK1/SLC7A5/EGFR/MAP2K1/MET/HRAS/RET/MTOR/PDHA1/SCO2/SIRT3/AKT2/PFKM/HK2/NTRK1	1.72204425220979
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	54/2701	155/9376	1.20935854104215	CREB5/CDKN1A/TCF7L1/NR4A1/FZD6/RAP1B/PDE8A/LDLR/PLCB4/ADCY4/PBX1/MAPK3/TCF7L2/KMT2A/CAMK2D/CDKN2C/BRAF/AHR/FZD8/MAPK1/GNAI3/ATF2/CREB1/WNT5A/RASD1/E2F3/EGFR/MAP2K1/APC/USP8/ITPR3/GSK3B/SP1/RAP1A/GNA11/ATF6B/WNT5B/CREB3L2/GNAQ/AXIN1/KMT2D/CACNA1C/WNT9A/PLCB1/GNAS/ADCY6/WNT2B/ARMC5/DVL1/LEF1/WDR5/NCEH1/CCNE2/ADCY1	1.6718211553382
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	126/2701	388/9376	1.12728008335973	BACE2/APP/TUBB6/INSR/RYR3/SLC39A14/AKT3/COX7A1/CAPN2/PPP3CA/FZD6/MCU/IKBKB/DDIT3/TUBB4B/PPP3CC/SNCA/NDUFS7/KLC1/PIK3CB/PLCB4/ATF6/TUBA1A/MAPK3/PSMB2/ERN1/PIK3R3/BECN1/EIF2S1/PSMD13/NDUFV1/LRP5/PSMB3/RELA/ATG101/BRAF/RTN3/CSNK1E/ATP5MC1/PTGS2/APH1B/ATP2A2/CYCS/RB1CC1/PSMB7/TNFRSF1A/CSNK2B/COX6A1/NDUFC1/NDUFB1/PSMD11/FZD8/PSEN1/ATG2B/MAPK1/GAPDH/NDUFA10/SEM1/ADAM10/PSMC5/ADAM17/PSMD2/CASP7/PSMC3/PSMD14/NDUFS4/WNT5A/ULK1/COX7A2/PSMD7/EIF2AK2/PSENEN/CSNK1A1/NDUFB2/NDUFS3/TUBA1C/CSNK2A1/PPP3CB/PSMA7/MAP2K1/MAPK8/APC/RTN4/ITPR3/PIK3C3/HRAS/SDHA/GSK3B/CSF1/MTOR/CSNK2A2/DKK1/SLC39A7/TUBA4A/WNT5B/IDE/AMBRA1/CASP3/CALML4/GNAQ/AXIN1/APBB1/PSEN2/EIF2AK3/ARAF/PIK3R4/NOX4/CACNA1C/SLC39A10/ATG13/IL6/ULK2/NOS1/TRAF2/AKT2/WNT9A/PLCB1/ATP5F1E/MAP2K7/PPIF/WNT2B/IRS2/DVL1/TUBB3/KLC2/CHRM5	1.62879743699634
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	47/2701	133/9376	1.22670244660151	GNG12/CREB5/AKT3/PPP2R1B/PPP3CA/PPP3CC/GNB5/PPP2R5C/PLCB4/PPP2R3A/CAMK2D/GNB1/MAOB/PPP2R5A/PPP2R5E/ARRB1/PPP2R2D/GNAI3/ATF2/CREB1/MAOA/PPP2CA/PPP2R3C/PPP3CB/MAPK8/PPP2CB/ITPR3/GSK3A/GSK3B/ATF6B/GNG11/CREB3L2/GNAL/CALML4/PPP2R5B/PPP2R5D/GNAQ/GRIA1/CACNA1C/MAPK12/AKT2/MAPK11/PLCB1/GNAS/LRTOMT/GNGT2/GNAO1	1.67493457008138
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	29/2701	78/9376	1.29061411253192	BTG1/PFKP/HSPD1/HSPA9/XRN2/TENT4A/LSM2/ENO1/DDX6/PNPT1/PATL1/NUDT16/BTG3/CNOT4/CNOT9/MTREX/ZCCHC7/CNOT1/EXOSC10/TENT4B/TOB2/DIS3/CNOT10/CNOT6/DCPS/PFKM/PAN2/DCP1B/ENO2	1.63942489622584
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	119/2701	368/9376	1.1225150105436	TUBB6/COX7A1/MAP1LC3A/OPTN/SQSTM1/PPP3CA/MCU/DDIT3/TUBB4B/PPP3CC/NUP153/NDUFS7/KLC1/NUP98/ATF6/UBQLN1/DCTN2/TUBA1A/TBK1/VCP/PSMB2/NXT1/MAP1LC3B/ERN1/DNAH14/BECN1/EIF2S1/PSMD13/NDUFV1/FUS/PSMB3/ATG101/ATP5MC1/DCTN3/BCL2/PINK1/CYCS/RB1CC1/PRKN/PSMB7/TNFRSF1A/COX6A1/NDUFC1/NDUFB1/PSMD11/ANXA7/ATG2B/NDUFA10/SEM1/PSMC5/PSMD2/PSMC3/PSMD14/NDUFS4/TARDBP/ATXN2L/ULK1/COX7A2/RAB8A/PSMD7/MAP2K3/SETX/NDUFB2/TPR/NDUFS3/RAB5A/TUBA1C/CHMP2B/PPP3CB/NUP88/PSMA7/DCTN1/ACTR1A/DERL1/ATXN2/ITPR3/PIK3C3/SDHA/MTOR/SEH1L/NUP58/TUBA4A/HSPA5/ALS2/DAXX/NUP188/ACTR1B/NUP107/WDR41/AMBRA1/CASP3/RAC1/DNAL1/EIF2AK3/DNAH6/NUP205/PIK3R4/GRIA1/SIGMAR1/ATG13/ACTG1/NUP43/ULK2/NOS1/MAPK12/TRAF2/NUP155/ANG/MAPK11/NUP85/NUP35/ATP5F1E/HDAC6/DNAL4/MATR3/TUBB3/DNAH1/KLC2/MAP2K6	1.52518075838192
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	51/2701	148/9376	1.19619360196924	SHC1/FLT4/CDKN1A/AKT3/TCF7L1/FZD6/MYC/PIK3CB/FGFR1/MAPK3/TCF7L2/PIK3R3/GADD45A/LRP5/POLK/HES1/BRAF/FZD8/MAPK1/NOTCH1/WNT5A/E2F3/RPS6KB1/NFKB2/CSNK1A1/FGF2/EGFR/MAP2K1/APC/SOS2/HRAS/GSK3B/MTOR/SP1/WNT5B/GADD45B/AXIN1/ARAF/DDB2/PGR/AKT2/WNT9A/GADD45G/IGF1R/WNT2B/BRCA1/SHC2/DVL1/DLL1/LEF1/ESR2	1.53032685880699
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	12/2701	28/9376	1.48770296715502	ELOVL5/ELOVL1/ELOVL7/HADHA/TECR/HSD17B12/HACD2/ACOT7/THEM4/HACD1/MECR/PPT2	1.64398313099735
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	48/2701	139/9376	1.19872469295944	SHC1/CREB5/AKT3/GABBR1/HSPA1A/HSPA1B/HSP90AB1/HSPA8/PIK3CB/PLCB4/FKBP4/ADCY4/HSPA6/FKBP5/MAPK3/HSP90AA1/PIK3R3/MMP2/BCL2/EBAG9/NOS3/MAPK1/RARA/GNAI3/ATF2/CREB1/EGFR/GREB1/MAP2K1/SOS2/ITPR3/HRAS/SP1/ATF6B/CREB3L2/CALML4/GNAQ/PGR/HBEGF/AKT2/PLCB1/GNAS/ADCY6/SHC2/HSPA1L/ESR2/GNAO1/ADCY1	1.50146792219535
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	25/2701	67/9376	1.29526377737378	RPS6KA2/PPP3CA/RPS6KA3/RAP1B/PPP3CC/PLCB4/MAPK3/CAMK2D/BRAF/MAPK1/PPP3CB/MAP2K1/ITPR3/HRAS/RAP1A/CREBBP/EP300/CALML4/GNAQ/ARAF/GRIA1/CACNA1C/PLCB1/RPS6KA6/ADCY1	1.54283098727948
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	14/2701	34/9376	1.42936167432541	POLR2L/POLR2H/POLR2I/POLR2J3/POLR1D/POLR2B/POLR1C/POLR3GL/CRCP/POLR3C/POLR3E/POLR2D/POLR2M/POLR1E	1.5953835075204
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	9/2701	20/9376	1.56208811551277	SOAT1/EBP/HSD17B7/CYP51A1/MSMO1/LSS/DHCR7/DHCR24/NSDHL	1.60065077575178
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	26/2701	71/9376	1.2711828170057	IKBKB/NOD1/PTPN11/NFKBIA/PLCG2/F11R/RELA/CXCL2/ADAM10/MAP3K14/ADAM17/GIT1/EGFR/MAPK8/MET/CXCL1/MAP2K4/PLCG1/CASP3/RAC1/ATP6V0A2/MAPK12/HBEGF/MAPK11/CXCL3/ATP6V1E2	1.45900052681074
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	10/2701	23/9376	1.50926387972249	RFC1/POLD4/MLH1/POLD2/RFC2/MLH3/POLD3/RPA1/PMS2/RPA4	1.5554412795054
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	6/2701	12/9376	1.73565346168086	VKORC1/VKORC1L1/COQ7/COQ4/COQ2/COQ6	1.62201736252587
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	52/2701	154/9376	1.17212961048577	CDKN1A/NFATC1/PRKAG2/RYR3/MYL9/CAMKK2/PPP3CA/PPP3CC/PRKAA2/PLCB4/NFATC2/PLA2G4C/ADCY4/MAPK3/CAMK2D/ROCK2/PPP1R12B/PTGS2/CACNB2/MYL6B/PPP1R12C/NPR1/NOS3/MAPK1/GNAI3/OXTR/ROCK1/PPP3CB/PRKAA1/EGFR/MAP2K1/ITPR3/HRAS/CAMK1/PRKAG1/CD38/RCAN1/MAPK7/CALML4/GNAQ/CACNA1C/ACTG1/ELK1/PLCB1/GNAS/ADCY6/PLA2G4A/MYL6/KCNJ2/KCNJ14/GNAO1/ADCY1	1.37001613740219
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	19/2701	50/9376	1.31909663087745	SAT2/P4HA3/ALDH2/MAOB/P4HA1/AZIN2/ALDH9A1/NOS3/OAT/ODC1/MAOA/ALDH3A2/GOT2/GOT1/ARG2/NOS1/CKB/ALDH4A1/SAT1	1.43906963899545
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	13/2701	32/9376	1.4102184376157	BECN1/BCL2/CYCS/TNFRSF1A/CASP7/BCL2L11/MAPK8/HTRA2/BIRC3/CASP3/BIRC6/BOK/BBC3	1.47858414789756
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	18/2701	47/9376	1.32943669405342	INSR/SOCS2/PKM/IKBKB/PRKCZ/PRKCE/PIK3CB/HK1/MAPK3/PIK3R3/MAPK1/SOCS4/MAPK8/SOCS3/MTOR/CACNA1C/IRS2/HK2	1.44020942530625
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	14/2701	35/9376	1.38852276934469	PFKP/ENOSF1/HK1/GMDS/PFKFB3/TPI1/PMM2/TKFC/PFKM/ALDOC/HK2/ALDOB/ALDOA/KHK	1.46479249815075
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	64/2701	193/9376	1.15110695904223	CCL14/CCL21/GNG12/SHC1/AKT3/BCAR1/VAV3/RAP1B/IKBKB/STAT3/PXN/PRKCZ/PARD3/GNB5/PIK3CB/PLCB4/ADCY4/TIAM1/MAPK3/GRK5/PIK3R3/NFKBIA/STAT1/GNB1/ROCK2/PLCG2/RELA/BRAF/STAT5B/PTK2B/NFKBIB/ARRB1/MAPK1/GNAI3/CXCL2/ROCK1/PTK2/CX3CL1/MAP2K1/SOS2/GSK3A/HRAS/GSK3B/CXCL1/RAP1A/CCL23/GNG11/PLCG1/RAC1/GNAQ/FOXO3/AKT2/PLCB1/ADCY6/CXCL3/ELMO1/CXCR4/SHC2/CCL16/ITK/CXCL13/GNGT2/JAK2/ADCY1	1.34925216408845
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	35/2701	100/9376	1.2149574231766	CD9/CD55/CD59/HLA-DRB1/IL7/HLA-DPA1/HLA-DPB1/HLA-DRB5/ITGA1/HLA-DQB1/ITGA6/ITGA5/CSF3/IL4R/ITGB3/HLA-DMA/IL3RA/HLA-DRA/IL1R1/HLA-DQA1/IL6R/HLA-DQA2/CSF1/HLA-DOA/CD38/IL6/FLT3LG/IL7R/GP1BB/CD2/IL11RA/CD22/CD3E/HLA-DQB2/CD8A	1.37465707812384
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	40/2701	116/9376	1.19700238736611	ACTN1/MYL9/RAPGEF4/BCAR1/VAV3/RAP1B/PXN/CTNNA1/CLDN5/PIK3CB/CD99/PTPN11/MYL12A/PIK3R3/VCAM1/MSN/ROCK2/PLCG2/F11R/PTK2B/MMP2/GNAI3/ROCK1/THY1/PTK2/VCL/RAP1A/CD99L2/ARHGAP35/PLCG1/RAC1/MYL12B/ACTG1/ITGB1/MAPK12/MAPK11/ICAM1/CXCR4/ITK/CLDN12	1.35805477137665
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	7/2701	15/9376	1.61994323090214	ST6GALNAC3/ST3GAL1/ST8SIA1/ST6GALNAC6/SLC33A1/ST6GALNAC4/HEXB	1.52847635429041
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	24/2701	66/9376	1.26229342667699	RORA/NFATC1/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/STAT3/HLA-DQB1/TGFB2/SMAD3/IL4R/HLA-DMA/STAT1/RELA/SMAD2/HLA-DRA/HLA-DQA1/HLA-DQA2/HLA-DOA/IL6/TGFB3/IFNG/IL18R1/HLA-DQB2	1.36021271255963
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	9/2701	21/9376	1.48770296715502	CHST15/CSGALNACT1/CHSY3/CHST7/CHST12/CHSY1/DSEL/CHST11/UST	1.42319839251178
Human Diseases	Cancer: specific types	hsa05218	Melanoma	26/2701	73/9376	1.23635589051239	CDKN1A/AKT3/PDGFD/PIK3CB/PDGFA/FGFR1/MAPK3/PIK3R3/GADD45A/POLK/BRAF/MAPK1/E2F3/FGF2/EGFR/MAP2K1/MET/HRAS/MDM2/GADD45B/ARAF/DDB2/PDGFB/AKT2/GADD45G/IGF1R	1.28955136414843
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	11/2701	27/9376	1.41423615396218	OXCT1/HADHA/ACADS/HMGCS1/ACAT1/AACS/L2HGDH/ALDH5A1/EHHADH/ACSM2B/ACSM2A	1.37110147581355
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	14/2701	36/9376	1.34995269241845	PGM2L1/HK1/GPI/PGM2/GYG1/PGM1/GBE1/UGP2/PYGB/GYS1/GANC/G6PC3/AGL/HK2	1.33816432242895
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	12/2701	30/9376	1.38852276934469	PIGK/PIGG/DPM2/PIGH/PGAP2/PGAP1/PIGA/PIGZ/PIGP/PIGS/PIGQ/PIGW	1.3557715302988
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	13/2701	33/9376	1.36748454556674	ACO1/BCKDHB/DLST/OGDH/ACO2/IDH3B/IDH3A/CS/GOT2/PDHA1/GOT1/BCAT2/DHTKD1	1.34516379717479
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	36/2701	105/9376	1.19016237372402	LMNA/SNTB2/DES/ITGA9/ITGB4/TPM4/ITGA1/TGFB2/TPM2/ITGAV/ITGA6/ITGA5/ADCY4/ITGB3/SGCD/CACNB2/ATP2A2/TTN/ITGA8/TPM3/EMD/ITGA10/CACNA1C/ACTG1/ITGB1/NOS1/GNAS/ADCY6/ITGB8/TGFB3/ITGA11/PLN/DMD/SNTA1/ITGA7/ADCY1	1.24645970721412
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	48/2701	144/9376	1.15710230778724	SMAD1/AKT3/JAK1/FZD6/MYC/STAT3/JARID2/SMAD3/PIK3CB/KAT6A/FGFR1/INHBB/MAPK3/PIK3R3/SMAD2/FZD8/MAPK1/SMAD4/WNT5A/FGF2/RIF1/SKIL/MAP2K1/APC/ACVR1B/ZFHX3/HRAS/GSK3B/SMARCAD1/LIF/WNT5B/PCGF2/PCGF3/PCGF5/AXIN1/MAPK12/AKT2/MAPK11/WNT9A/IGF1R/BMPR2/WNT2B/INHBA/DVL1/HOXD1/PCGF6/ID4/JAK2	1.2084764961492
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	35/2701	103/9376	1.17957031376369	ACTN1/HSPB1/LAMA4/LAMA3/LAMB1/TGFB2/PIK3CB/PLCB4/PIK3R3/RELA/IL1R1/LAMB2/GNA14/CXCL2/RAB7A/RAB5A/PTK2/COL4A5/VCL/CXCL1/PRDX1/GNA11/CASP3/GNAL/GNAQ/ARG2/LAMC1/IL6/PLCB1/GNAS/TGFB3/CXCL3/IFNG/ADCY1/RAB7B	1.16564235386318
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	39/2701	116/9376	1.16707732768196	PFKP/PKM/PCCA/HK1/ME3/ACO1/GPI/ESD/TPI1/ENO1/GAPDH/MDH2/GLUD1/DLST/PRPS2/OGDH/ACO2/SDHA/ACSS2/IDH3B/IDH3A/PRPS1/CS/ACADS/GOT2/ACAT1/PDHA1/GOT1/TKFC/ALDH6A1/PFKM/ALDOC/ACOX3/IDNK/HK2/ALDOB/ALDOA/ENO2/AMT	1.15176351454904
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	7/2701	16/9376	1.51869677897075	ST3GAL1/ABO/A4GALT/ST8SIA1/GLA/HEXB/GBGT1	1.320863421037
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	8/2701	19/9376	1.46160291509967	IDS/GUSB/HYAL1/HGSNAT/HEXB/HPSE/IDUA/HYAL3	1.28114806155438
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	12/2701	31/9376	1.34373171226905	SEC62/GET3/SEC63/SEC11A/SRPRA/SRP54/GET1/HSPA5/SRP68/IMMP2L/SRP14/SEC61A2	1.21936321905984
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	36/2701	107/9376	1.16791634804693	FOXO1/CREB5/PRKAG2/AKT3/SIK2/PFKP/PKM/PPP3CA/PPP3CC/LDHA/PRKAA2/PLCB4/ACACB/CPT1A/CAMK2D/PPP4R3B/ATF2/CREB1/PPP3CB/PRKAA1/ITPR3/ACACA/PYGB/GYS1/CREBBP/PRKAG1/G6PC3/EP300/PDHA1/CREB3L2/CALML4/GNAQ/AKT2/PLCB1/GNAS/PFKM	1.11119613818449
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	26/2701	75/9376	1.20338640009873	PFKP/PKM/ASL/ASS1/MAT2A/ACO1/TPI1/ENO1/GAPDH/PRPS2/MTR/ACO2/IDH3B/IDH3A/PRPS1/CS/GOT2/GOT1/BCAT2/ARG2/PFKM/ALDOC/ALDOB/ALDOA/CTH/ENO2	1.12488989177328
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	26/2701	75/9376	1.20338640009873	CDKN1A/AKT3/PIK3CB/MAPK3/MGST2/PIK3R3/REV3L/MGST3/BCL2/GSTO1/CYCS/ERCC1/MAPK1/MLH1/GSTM3/MDM2/MGST1/BIRC3/GSTT2B/CASP3/AKT2/POLH/BBC3/BRCA1/GSTO2/GSTM2	1.12488989177328
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	97/2701	308/9376	1.09323627131846	TUBB6/CREB5/COX7A1/HIP1/IFT57/POLR2L/TUBB4B/NDUFS7/SOD2/KLC1/AP2B1/PLCB4/POLR2H/DCTN2/TUBA1A/SIN3A/POLR2I/PSMB2/ERN1/POLR2J3/DNAH14/BECN1/PSMD13/NDUFV1/PSMB3/ATG101/ATP5MC1/DCTN3/CYCS/RB1CC1/PSMB7/TAF4B/HDAC1/COX6A1/NDUFC1/NDUFB1/PSMD11/CLTB/ATG2B/AP2A1/NDUFA10/SEM1/PSMC5/POLR2B/TBPL1/PSMD2/PSMC3/PSMD14/NDUFS4/CREB1/ULK1/COX7A2/PSMD7/TGM2/NDUFB2/NDUFS3/TUBA1C/PSMA7/DCTN1/ACTR1A/MAPK8/PIK3C3/SDHA/PPARG/NRF1/MTOR/SP1/CREBBP/TUBA4A/ACTR1B/EP300/CREB3L2/AMBRA1/CASP3/DNAL1/GNAQ/DNAH6/PIK3R4/GRIA1/ATG13/POLR2D/ULK2/TRAF2/CLTCL1/PLCB1/ATP5F1E/MAP2K7/PPIF/BBC3/MAP3K10/TBP/TAF4/DNAL4/STX1A/TUBB3/DNAH1/KLC2	1.05834386053659
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	18/2701	50/9376	1.24967049241022	HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/IL15/HLA-DMA/CD40/HLA-DRA/IL15RA/MAP3K14/LTBR/HLA-DQA1/HLA-DQA2/HLA-DOA/IL6/CXCR4/HLA-DQB2	1.12596997465189
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	24/2701	69/9376	1.20741110377799	AKT3/VAV3/PIK3CB/PLA2G4C/MAPK3/PIK3R3/PLCG2/MAPK1/MAP2K3/MAP2K1/MAPK8/SOS2/HRAS/MAP2K4/FYN/PLCG1/RAC1/MAPK12/AKT2/MAPK11/MAP2K7/PLA2G4A/MAP2K6/LAT	1.09995263991186
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	50/2701	154/9376	1.12704770239017	RFK/VKORC1/AK2/GCH1/MTHFD1L/MAT2A/NME1/PTS/ALDH2/VKORC1L1/NME7/DHRS3/RDH11/GPHN/AK3/GUSB/DHODH/CMPK1/PMM2/NME2/PANK3/UGDH/GCLC/AK1/GSS/UGP2/ALDH3A2/NMNAT2/FPGS/SPR/COQ7/CTPS1/BCAT2/NMNAT3/COQ4/CTPS2/PPOX/TPK1/AK9/MMAB/NADSYN1/AK4/COQ2/COQ6/MOCS1/NFS1/LIAS/KMO/AK7/OXSM	1.01119965358189
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	14/2701	38/9376	1.27890255071221	NNMT/PNP/NT5E/NT5C2/SIRT2/NMNAT2/CD38/NMNAT3/SIRT3/NADSYN1/SIRT5/SIRT7/NT5M/AOX1	1.09582106573251
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	20/2701	57/9376	1.21800242924973	ELOVL5/ACSL4/ACSL5/ELOVL1/CPT1A/ELOVL7/HADHA/TECR/HSD17B12/HACD2/ACACA/HACD1/ACADS/ACAT1/ACADM/MECR/ACOX3/PPT2/EHHADH/OXSM	1.05011388353555
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	12/2701	32/9376	1.30174009626064	PFKP/HK1/PGM2/PGM1/UGP2/GANC/G6PC3/GLA/B4GALT2/GALK1/PFKM/HK2	1.08758671528566
Human Diseases	Immune disease	hsa05310	Asthma	12/2701	32/9376	1.30174009626064	HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/HLA-DMA/CD40/HLA-DRA/HLA-DQA1/HLA-DQA2/HLA-DOA/HLA-DQB2	1.08758671528566
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/2701	14/9376	1.48770296715502	ST3GAL1/ST3GAL3/CHST1/B4GALT2/B3GNT7/B4GALT4	1.1616021108171
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	9/2701	23/9376	1.35833749175024	GLS/ASL/ASS1/NOS3/GLUD1/GOT2/GOT1/ARG2/NOS1	1.09446781689382
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	9/2701	23/9376	1.35833749175024	FDPS/FNTA/PMVK/ZMPSTE24/HMGCS1/ACAT1/MVD/HMGCR/FNTB	1.09446781689382
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	7/2701	17/9376	1.42936167432541	CYP46A1/CYP39A1/CYP7B1/HSD3B7/CYP27A1/CYP8B1/ACOT8	1.12708146592598
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	7/2701	17/9376	1.42936167432541	GGT5/CSAD/FMO2/ADO/FMO4/FMO5/CDO1	1.12708146592598
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	7/2701	17/9376	1.42936167432541	TXNRD1/MTR/SEPHS1/SCLY/KYAT1/TXNRD3/CTH	1.12708146592598
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	7/2701	17/9376	1.42936167432541	NRP2/MYH11/MYH9/MYH10/PCDH7/CLEC4M/PCDH9	1.12708146592598
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	16/2701	45/9376	1.23424246163972	ABCB1/ABCA5/TAP1/ABCG1/TAP2/ABCA4/ABCG2/ABCC4/ABCD4/ABCA6/ABCB8/ABCB4/ABCC3/ABCB6/ABCC9/ABCA2	1.00191315949329
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	19/2701	55/9376	1.19917875534314	SPHK1/B4GALT5/CERS6/ACER3/SGMS2/UGCG/KDSR/ACER2/SPTLC1/CERS5/CERK/GBA2/PLPP1/CERS4/GLA/HEXB/B4GALT6/SPHK2/PLPP2	0.942356868233279
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	30/2701	91/9376	1.14438689781156	NFATC1/AKT3/RASGRP3/PPP3CA/VAV3/IKBKB/PPP3CC/PIK3CB/BCL10/NFATC2/MAPK3/PIK3R3/NFKBIA/PLCG2/RELA/IFITM1/NFKBIB/MALT1/MAPK1/PPP3CB/MAP2K1/SOS2/HRAS/GSK3B/RAC1/NFKBIE/AKT2/CD79B/CD81/CD22	0.880399572441843
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	11/2701	30/9376	1.27281253856596	ACLY/ACO1/MDH2/DLST/OGDH/ACO2/SDHA/IDH3B/IDH3A/CS/PDHA1	0.951994328466595
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	33/2701	101/9376	1.13418939080135	TCF7L1/FZD6/PLCB4/ADCY4/MAPK3/TCF7L2/CAMK2D/FZD8/MAPK1/GNAI3/CREB1/WNT5A/EDNRB/MAP2K1/HRAS/GSK3B/CREBBP/WNT5B/EP300/CREB3L2/CALML4/GNAQ/WNT9A/PLCB1/GNAS/ADCY6/WNT2B/DVL1/LEF1/GNAO1/MC1R/EDN1/ADCY1	0.862470410495605
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	15/2701	43/9376	1.21092101977734	ACSL4/ACSL5/CPT1A/ALDH2/HADHA/ALDH9A1/ECI2/ALDH3A2/ACADS/ACAT1/ECI1/ACADM/CYP2U1/ACOX3/EHHADH	0.881791184136718
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	6/2701	15/9376	1.38852276934469	AK2/AK1/TPK1/AK4/NFS1/AK7	0.957906847668327
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	29/2701	89/9376	1.13110000873584	TUBB6/PDGFD/TUBB4B/PRKG1/PDGFA/PLCB4/TUBA1A/ADCY4/MAPK3/MAPK1/GNAI3/CSNK1D/TUBA1C/EGFR/MAP2K1/GJA1/SOS2/ITPR3/HRAS/GNA11/TUBA4A/MAPK7/GNAQ/PDGFB/PLCB1/GNAS/ADCY6/TUBB3/ADCY1	0.790464365390881
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	25/2701	76/9376	1.14187727742162	UBC/ACSL4/FABP4/PLIN2/ACSL5/FABP5/ME3/SORBS1/PLIN5/CPT1A/APOA2/ILK/PPARD/CYP27A1/PPARG/APOC3/SLC27A4/HMGCS1/ACADM/SLC27A1/CYP8B1/ANGPTL4/ACOX3/EHHADH/APOA1	0.789951563591303
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	21/2701	63/9376	1.15710230778724	CDKN1A/TCF7L1/BMP2/FZD6/TCF7L2/GADD45A/POLK/FZD8/WNT5A/APC/GSK3B/WNT5B/GADD45B/AXIN1/DDB2/WNT9A/GADD45G/WNT2B/DVL1/LEF1/PTCH1	0.795848373936286
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	28/2701	86/9376	1.13019295179219	CREB5/KCNN3/RAPGEF4/ATP1A1/PCLO/PLCB4/ADCY4/VAMP2/CAMK2D/ATF2/CREB1/ITPR3/GNA11/ATF6B/CREB3L2/GNAQ/CACNA1C/FXYD2/PLCB1/GNAS/ADCY6/TRPM4/KCNMB1/KCNN2/KCNMA1/STX1A/KCNMB3/ADCY1	0.77152701509294
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	52/2701	166/9376	1.0873973494868	PDE2A/CREB5/NFATC1/INSR/AKT3/MYL9/ATP2B4/ATP1A1/PPP3CA/PPP3CC/PRKG1/PRKCE/PLCB4/NFATC2/ADCY4/MAPK3/ROCK2/ATP2B1/ATP2A2/BDKRB2/NPR1/NOS3/MAPK1/GNAI3/GNA12/ATF2/CREB1/ROCK1/EDNRB/MEF2D/PPP3CB/MAP2K1/ITPR3/GNA11/ATF6B/CREB3L2/CALML4/GNAQ/CACNA1C/AKT2/FXYD2/PLCB1/ADCY6/PPIF/IRS2/ADRA2C/MEF2B/KCNMB1/PLN/KCNMA1/KCNMB3/ADCY1	0.72267792034166
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	27/2701	83/9376	1.12922032446706	IKBKB/POLR2L/MLKL/POLR2H/TBK1/POLR1D/NFKBIA/RELA/ADAR/NFKBIB/G3BP1/IRF3/RIPK1/GSDMD/CASP7/POLR1C/POLR3GL/POLR3C/DNASE2/IL33/CGAS/CASP3/IRF7/POLR3E/DDX41/IL6/AIM2	0.752166869221593
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	11/2701	31/9376	1.23175406957996	PFKP/GPI/PGM2/PGM1/PRPS2/PRPS1/PFKM/ALDOC/IDNK/ALDOB/ALDOA	0.822130685725172
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	11/2701	31/9376	1.23175406957996	DPYD/ALDH2/HADHA/ALDH9A1/ALDH3A2/CSAD/ACADS/AOC3/ALDH6A1/ACOX3/EHHADH	0.822130685725172
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	22/2701	67/9376	1.13983212408892	PFKP/PKM/LDHA/HK1/GPI/ALDH2/PGM2/TPI1/ENO1/PGM1/ALDH9A1/GAPDH/ACSS2/ALDH3A2/G6PC3/PDHA1/PFKM/ALDOC/HK2/ALDOB/ALDOA/ENO2	0.73065966973794
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	49/2701	157/9376	1.08340152385175	INSR/PRKAG2/AKT3/COX7A1/IKBKB/DDIT3/NDUFS7/PIK3CB/PRKAA2/LEPR/ERN1/PIK3R3/EIF2S1/NDUFV1/RELA/MLXIP/CYCS/TNFRSF1A/COX6A1/NDUFC1/NDUFB1/NDUFA10/CASP7/BCL2L11/NDUFS4/COX7A2/IL6R/NDUFB2/NDUFS3/PRKAA1/MAPK8/GSK3A/SOCS3/SDHA/GSK3B/PPARG/ADIPOR2/ITCH/PRKAG1/CASP3/RAC1/EIF2AK3/IL6/MAPK12/TRAF2/AKT2/MAPK11/MLX/IRS2	0.670353991751818
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	7/2701	19/9376	1.27890255071221	BCKDHB/DLST/OGDH/PDHA1/DHTKD1/LIAS/AMT	0.774075402297598
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	52/2701	168/9376	1.07445214294529	CDKN1A/AKT3/IL7/JAK1/SOCS2/MCL1/CCND3/MYC/STAT3/GHR/OSMR/IL15/PIK3CB/PDGFA/FHL1/PTPN11/CSF3/LEPR/IL4R/PIK3R3/STAT1/IL3RA/SOCS5/STAT5B/BCL2/STAT5A/IL15RA/CLCF1/IFNAR1/IL6R/EGFR/SOCS4/SOS2/HRAS/SOCS3/MTOR/PIAS1/LIF/SOCS6/CREBBP/EP300/PDGFB/IL6/PIAS3/AKT2/TSLP/TYK2/IL7R/IL11RA/IFNG/AOX1/JAK2	0.619400402636826
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	25/2701	78/9376	1.11259837287235	SERPING1/IRF1/NOD1/ITGA5/MAPK3/RELA/C1S/C1R/IRF3/MAPK1/GNAI3/CASP7/CFL2/IRF8/TICAM1/MAPK8/IRAK4/TRAF6/C3/CASP3/CALML4/IL6/ITGB1/MAPK12/MAPK11	0.635194809203107
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	11/2701	32/9376	1.19326175490559	LDHA/PCCA/ACACB/HADHA/BCKDHB/ACSS2/ACACA/ACADS/ALDH6A1/ACOX3/EHHADH	0.696589282673762
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	6/2701	16/9376	1.30174009626064	MAOB/MAOA/MIF/GOT2/GOT1/AOC3	0.768382361274201
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	31/2701	98/9376	1.09806647575728	PDE2A/CREB5/ATP2B4/ATP1A1/NR4A1/PRKD2/PRKD1/LDLR/PRKCE/PLCB4/ADCY4/CAMK2D/ATP2B1/NPR1/DAGLB/ATF2/CREB1/PRKD3/ITPR3/CAMK1/GNA11/ATF6B/ATF1/CREB3L2/CALML4/GNAQ/CACNA1C/PLCB1/GNAS/ADCY6/ADCY1	0.620767136499145
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	21/2701	65/9376	1.12149915985532	CREB5/NR4A1/PDE8A/LDLR/PLCB4/ADCY4/PBX1/ATF2/CREB1/ITPR3/SP1/GNA11/ATF6B/CREB3L2/GNAQ/CACNA1C/PLCB1/GNAS/ADCY6/NCEH1/ADCY1	0.625250553917296
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	24/2701	75/9376	1.11081821547575	CDKN1A/SESN3/THBS1/SERPINE1/CCND3/PPP1R13L/TNFRSF10B/GADD45A/BCL2/CYCS/TNFRSF10A/TP53I3/ATR/PERP/MDM2/ZNF385A/GADD45B/CASP3/DDB2/CD82/GADD45G/GORAB/BBC3/CCNE2	0.612913598709215
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	14/2701	42/9376	1.15710230778724	SLC39A14/MAP1LC3A/ACSL4/SAT2/ACSL5/MAP1LC3B/SLC3A2/GCLC/ATG5/GSS/HMOX1/LPCAT3/TF/SAT1	0.649076083447307
NA	NA	hsa04519	Cadherin signaling	121/2701	404/9376	1.03967360823457	ACTN1/CDH13/MYO1D/WWTR1/FLT4/DES/SCN3B/TCF7L1/YWHAG/TEAD4/DSP/JUP/FZD6/VAV3/RRAS2/IKBKB/PCDH17/ARPC5L/TEAD1/CTNNA1/CELSR1/YWHAQ/LATS2/ANKRD6/TEAD2/PCDH7/FGFR1/YAP1/MAPK3/TCF7L2/MYO1E/GABRE/NCKAP1/DAAM1/NFKBIA/ROCK2/LRP5/ERBIN/LHFPL2/RELA/YWHAH/PTK2B/APH1B/RYK/MPDZ/MYO1C/FZD8/PSEN1/MAPK1/BRK1/YWHAZ/ADAM10/LHFPL6/MYO1B/ROCK1/WNT5A/ATN1/SHOC2/MAP2K3/AMOTL1/PSENEN/WASF1/CSNK1A1/PTK2/EGFR/VCL/MAP2K1/LIMA1/STK3/MAPK8/GJA1/APC/MET/SAV1/HRAS/GSK3B/LIMD1/YWHAE/TAOK1/YWHAB/FAT4/ENAH/CDH22/CREBBP/WNT5B/VANGL1/ARHGAP35/EP300/RAC1/AXIN1/CDH24/PSEN2/PCDH19/CDH23/ACTG1/MRAS/NF2/WTIP/MAPK12/VIM/DCHS1/MAPK11/WNT9A/TMC1/IGF1R/WNT2B/PCDHB4/CDH26/PCDH9/LHFPL5/PRICKLE4/DVL1/LEF1/ACTR3B/PRICKLE3/LHFPL3/CIB2/ACTR3C/GABRR2/PCDHGB7/SCN5A	0.518525412730706
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	19/2701	59/9376	1.1178785007436	TXNDC12/MGST2/PRDX6/GSTK1/GGT5/MGST3/GSTO1/ODC1/GCLC/GGCT/GSS/GSTM3/MGST1/GSTT2B/LANCL1/RRM1/CHAC2/GSTO2/GSTM2	0.577756522283382
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	12/2701	36/9376	1.15710230778724	POLE4/RFC1/RNASEH2C/POLD4/POLD2/RFC2/RNASEH1/POLD3/RPA1/POLE2/RPA4/DNA2	0.600734635871185
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	8/2701	23/9376	1.20741110377799	LARGE1/B3GALNT2/ST3GAL3/RXYLT1/B4GALT2/CRPPA/POMT1/POMK	0.633494354282236
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	47/2701	154/9376	1.05942484024676	CREB5/AKT3/ATP2B4/RAPGEF4/PPP2R1B/ATP1A1/TPM4/TPM2/PPP2R5C/PLCB4/ADCY4/MAPK3/PPP2R3A/CAMK2D/ATP2B1/PPP2R5A/CACNB2/ATP2A2/BCL2/PPP2R5E/PPP2R2D/MAPK1/GNAI3/ATF2/CREB1/PPP2CA/PPP2R3C/PPP2CB/TPM3/ATF6B/CREB3L2/CALML4/PPP2R5B/PPP2R5D/GNAQ/CACNA1C/MAPK12/AKT2/FXYD2/MAPK11/PLCB1/GNAS/ADCY6/PLN/POPDC2/SCN5A/ADCY1	0.472974927851438
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	17/2701	53/9376	1.11343806975753	ATP2B4/DNM3/RAB11A/ATP1A1/AP2B1/PLCB4/ATP2B1/BDKRB2/CLTB/AP2A1/DNM2/GNAQ/FXYD2/CLTCL1/PLCB1/GNAS/ADCY6	0.526794480504285
Genetic Information Processing	Transcription	hsa03040	Spliceosome	73/2701	243/9376	1.04282059837615	HSPA1A/HSPA1B/HSPA8/SF1/SNU13/SNRPB/SRSF4/DDX39B/HSPA6/SNW1/HNRNPU/RBMX/SNRNP70/RBM8A/FUS/CWC25/LSM2/SNRPA/PRPF38B/DDX46/DHX15/SF3B2/CTNNBL1/SF3B3/CASC3/SRSF10/PRPF18/RBM25/TCERG1/HNRNPM/DDX23/ACIN1/PRPF3/ZMAT2/SLU7/CDC5L/TRA2A/DDX5/DDX42/SF3A2/EFTUD2/RBM22/PRPF6/THOC1/PRPF8/SNRPA1/SF3A3/PQBP1/ISY1/THOC7/BCAS2/DHX8/SNRNP40/SNIP1/SMNDC1/PPIE/SF3A1/PHF5A/DHX38/USP39/RBMX2/PRPF4/PRPF40B/XAB2/PLRG1/THOC5/DHX16/U2AF1L4/YJU2/GPKOW/HSPA1L/RBMXL1/BUD13	0.430201019341757
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	30/2701	97/9376	1.07360007939022	GNG12/RYR3/PRKG1/GNB5/PLCB4/PER1/ADCY4/MAPK3/CAMK2D/GNB1/PER3/MAPK1/PER2/GNAI3/CREB1/RASD1/ITPR3/GNG11/CALML4/GNAQ/GRIA1/CACNA1C/NOS1/PLCB1/GNAS/ADCY6/GNGT2/ADCY10/GNAO1/ADCY1	0.463485186153943
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	16/2701	50/9376	1.11081821547575	ACKR1/THBS1/TGFB2/GYPC/CSF3/VCAM1/CD40/SELE/MET/THBS3/THBS2/IL6/CD81/ICAM1/TGFB3/IFNG	0.499770645964773
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	9/2701	27/9376	1.15710230778724	ELOVL5/ELOVL1/ELOVL7/TECR/HSD17B12/HACD2/ACOT7/HACD1/ACOX3	0.520000980118369
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	12/2701	37/9376	1.12582927244164	GLS/ASL/ASS1/ASRGL1/GLUD1/GOT2/GOT1/GFPT2/PPAT/ALDH5A1/ALDH4A1/DDO	0.487814443571862
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	68/2701	227/9376	1.03986286691012	AKT3/EPHX1/COX7A1/AKR1C3/PRKD2/IKBKB/PRKD1/ABL2/NDUFS7/SOD2/PIK3CB/HIF1A/PTPN11/MAPK3/MGST2/PIK3R3/NFKBIA/NDUFV1/RELA/BRAF/ATP5MC1/MGST3/NFE2L2/VEGFA/GSTO1/COX6A1/NDUFC1/NDUFB1/AHR/MAPK1/NDUFA10/MAP3K14/NDUFS4/PRKD3/PTPN1/COX7A2/NDUFB2/NDUFS3/PTK2/ABL1/EGFR/MAP2K1/MAPK8/MET/SOS2/HRAS/GSTM3/SDHA/HMOX1/MAP2K4/MGST1/GSTT2B/RAC1/ARAF/NOX4/FOXO3/MAPK12/PLD2/EPHX2/AKT2/MAPK11/ATP5F1E/MAP2K7/PPIF/AS3MT/GSTO2/EPHX4/GSTM2	0.386738082604586
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	17/2701	54/9376	1.0928188462435	HLA-DRB1/HLA-B/HLA-A/HLA-F/HLA-E/HLA-C/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/HLA-DMA/CD40/HLA-DRA/HLA-DQA1/HLA-DQA2/HLA-DOA/HLA-DQB2	0.435111730221058
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	35/2701	115/9376	1.05648471580574	GNG12/CREB5/AKT3/GNB5/PIK3CB/PLCB4/ADCY4/MAPK3/PIK3R3/CAMK2D/GNB1/BCL2/MAPK1/GNAI3/CREB1/MAP2K1/ITPR3/HRAS/FYN/GNA11/GNG11/CREB3L2/GNAQ/CACNA1C/AKT2/PLCB1/ADCY6/KCNJ2/KCNJ14/GNGT2/ACHE/CHRM5/GNAO1/JAK2/ADCY1	0.387679843397955
Organismal Systems	Digestive system	hsa04978	Mineral absorption	19/2701	61/9376	1.08122674662086	MT2A/MT1X/MT1E/MT1G/MT1M/ATP2B4/ATP1A1/SLC30A1/MT1A/ATP2B1/HEPH/MT1F/HMOX2/TRPM6/TRPM7/HMOX1/MT1H/TF/FXYD2	0.404850650971251
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	48/2701	160/9376	1.04139207700852	HLA-DRB1/HLA-B/HLA-A/HLA-F/HLA-E/NECTIN3/HLA-C/ITGA9/NRXN3/HLA-DPA1/HLA-DPB1/HLA-DRB5/CLDN5/HLA-DQB1/SDC4/ITGAV/CD99/ITGA6/PVR/PTPRM/VCAM1/HLA-DMA/F11R/CD40/SELE/HLA-DRA/NECTIN2/ALCAM/NLGN1/CD274/HLA-DQA1/HLA-DQA2/ITGA8/CD99L2/NCAM1/NEO1/HLA-DOA/CXADR/ITGB1/ITGB8/ICAM1/PTPRF/NLGN2/CD2/CD22/CLDN12/HLA-DQB2/CD8A	0.335914130307829
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	33/2701	109/9376	1.05094613276089	AKT3/JAK1/IKBKB/PIK3CB/TBK1/MAPK3/PIK3R3/NFKBIA/STAT1/CD40/RELA/IRF3/RIPK1/MAPK1/TRAF3/TICAM1/IFNAR1/MAP2K3/MAP2K1/MAPK8/IRAK4/MAP2K4/TRAF6/IRF7/RAC1/IL6/MAPK12/AKT2/MAPK11/MAP2K7/TYK2/MAP2K6/TLR3	0.340311939176037
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	30/2701	99/9376	1.05191118889749	PRKCH/PRKCE/PIK3CB/PLCB4/PLA2G4C/ADCY4/PIK3R3/CAMK2D/PLCG2/IL1R1/BDKRB2/MAP2K3/MAPK8/ITPR3/PLCG1/PRKCQ/CALML4/GNAQ/PLA2G6/MAPK12/MAPK11/PLCB1/GNAS/ADCY6/PLA2G4A/BDKRB1/NGF/MAP2K6/NTRK1/ADCY1	0.330291266043886
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	20/2701	65/9376	1.06809443795745	KCNN3/AKT3/GABBR1/PIK3CB/PLCB4/MAPK3/PIK3R3/ARRB1/MAPK1/MAP2K1/ITPR3/HRAS/GNA11/GNAQ/TRPC4/CACNA1C/AKT2/PLCB1/KCNN2/ESR2	0.350422876193393
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	9/2701	28/9376	1.11577722536627	GCNT2/B3GNT5/ABO/A4GALT/ST3GAL6/ST8SIA1/ST3GAL3/B4GALT2/B4GALT4	0.390269935338164
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/2701	18/9376	1.15710230778724	ACSL4/ACSL5/ACACB/ACACA/MECR/OXSM	0.424374805077074
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	18/2701	59/9376	1.05904279017815	INSR/AKT3/PNPLA2/MGLL/FABP4/PRKG1/PIK3CB/ADCY4/PIK3R3/PTGS2/NPR1/GNAI3/PTGER3/AKT2/GNAS/ADCY6/IRS2/ADCY1	0.2893857395882
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	13/2701	42/9376	1.07445214294529	ALDH2/MAOB/HADHA/ALDH9A1/DLST/MAOA/ALDH3A2/ACAT1/KYAT1/DHTKD1/EHHADH/KMO/AOX1	0.307602771899672
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	17/2701	56/9376	1.05378960173481	MAN2A1/DAD1/DPM3/KRTCAP2/GANAB/ALG13/MGAT4A/ST6GAL1/DHRSX/DPM2/SRD5A3/DPAGT1/B4GALT2/ALG8/ALG6/ALG11/MGAT5	0.25680689583413
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	69/2701	235/9376	1.01923479877429	CREB5/PRKAG2/RPS6KA2/COX7A1/PNPLA2/MGLL/ACSL4/RPS6KA3/PRKG1/ACSL5/NDUFS7/PRKAA2/ADCY4/FGFR1/ZNF516/NDUFAF2/CPT1A/SLC25A29/NDUFV1/SMARCA2/SMARCE1/ATP5MC1/SMARCC1/COX6A1/NDUFC1/NDUFB1/NPR1/COA3/NDUFA10/COX20/ARID1B/ATF2/NDUFS4/CREB1/SMARCA4/COX7A2/RPS6KB1/MAP2K3/SMARCC2/NDUFB2/NDUFS3/COA4/PRKAA1/RPTOR/SOS2/HRAS/SDHA/PPARG/MTOR/CNR1/PRKAG1/SMARCD1/KDM3A/CREB3L2/NDUFAF7/KDM1A/KDM3B/ACTG1/MAPK12/MAPK11/GNAS/ADCY6/ATP5F1E/RPS6KA6/COX19/AKT1S1/COA7/ADCY10/ADCY1	0.189953377152427
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	4/2701	12/9376	1.15710230778724	NPC1/ASGR1/NCAM1/CLEC4M	0.34638954915206
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	39/2701	133/9376	1.0179020301587	SHC1/NFATC1/HLA-B/HLA-A/HLA-E/HLA-C/PPP3CA/VAV3/PPP3CC/TNFRSF10B/PIK3CB/NFATC2/PTPN11/MAPK3/PIK3R3/PLCG2/BRAF/PTK2B/MAPK1/IFNAR1/TNFRSF10A/PPP3CB/MAP2K1/SOS2/HRAS/FYN/SH3BP2/PLCG1/CASP3/RAC1/MICA/ARAF/ICAM1/KLRD1/SHC2/MICB/IFNG/LCK/LAT	0.132264691612045
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	14/2701	47/9376	1.03400631759711	PKM/LDHA/ME3/ACACB/ALDH2/ALDH9A1/ACYP2/MDH2/ACYP1/ACSS2/ALDH3A2/ACACA/ACAT1/PDHA1	0.148666557209227
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	9/2701	30/9376	1.04139207700852	IKBKB/RELA/GART/ABCG2/MTR/ABCC4/FPGS/IL6/ABCC3	0.144439924802178
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	11/2701	37/9376	1.03201016640484	LAMA4/PLCB4/VCAM1/SELE/APOL1/GNAQ/IL6/PLCB1/ICAM1/APOA1/IFNG	0.124096891052595
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	15/2701	52/9376	1.00133853558511	OSBPL5/LDLR/LRPAP1/NPC1/APOA2/VAPA/CYP27A1/SOAT1/APOC3/STARD3/APOB/ANGPTL4/NCEH1/APOA1/LCAT	0.00615676753702235
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	11/2701	38/9376	1.00485200413102	TAP1/CD40/ADA/TAP2/CIITA/DCLRE1C/IL7R/RFX5/LCK/CD3E/CD8A	0.0190637494143365
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	48/2701	168/9376	0.991801978103348	JAK1/CAPN2/SQSTM1/CHMP3/STAT3/HSP90AB1/CHMP4B/TNFRSF10B/MLKL/PLA2G4C/HSP90AA1/TNFAIP3/RBCK1/CAMK2D/STAT1/STAT5B/CHMP4A/BCL2/TNFRSF1A/RIPK1/STAT5A/SPATA2L/GLUD1/TICAM1/IFNAR1/EIF2AK2/CHMP2A/TNFRSF10A/CHMP2B/DNM1L/TRPM7/MAPK8/VPS4A/PYGB/IL33/CFLAR/TRAF5/BIRC3/TRAF2/PPIA/TYK2/PLA2G4A/CHMP4C/RNF31/IFNG/SPATA2/TLR3/JAK2	-0.06820298063607
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/2701	31/9376	1.00779878420179	PCCA/ACO1/MDH2/ACO2/ACSS2/CS/ACAT1/HYI/AMT	0.0276656190558384
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	33/2701	116/9376	0.987526969577041	GNG12/SLC38A1/SHANK3/PPP3CA/PPP3CC/GNB5/HOMER1/GLS/HOMER3/PLCB4/PLA2G4C/ADCY4/MAPK3/GNB1/MAPK1/GNAI3/PPP3CB/ITPR3/GNG11/SLC38A2/GNAQ/GRIA1/CACNA1C/SLC1A1/PLD2/PLCB1/GNAS/ADCY6/PLA2G4A/GNGT2/GNAO1/LZTS3/ADCY1	-0.0859840264166282
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	8/2701	28/9376	0.991801978103348	AKR1C3/GCH1/PCBD1/PTS/GPHN/FPGS/SPR/MOCS1	-0.0276344632148993
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/2701	10/9376	1.04139207700852	SQOR/MPST/SUOX	0.0833033444825361
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	76/2701	268/9376	0.984400470804069	TUBB6/RYR3/SLC39A14/COX7A1/TXN/UBC/MCU/DDIT3/TUBB4B/SNCA/NDUFS7/KLC1/ATF6/TUBA1A/UBE2L6/UBE2G1/PSMB2/UBE2G2/ERN1/CAMK2D/EIF2S1/PSMD13/NDUFV1/PSMB3/MAOB/ATP5MC1/NFE2L2/UBE2J1/PINK1/CYCS/PRKN/PSMB7/PARK7/COX6A1/NDUFC1/NDUFB1/PSMD11/GNAI3/NDUFA10/SNCAIP/SEM1/PSMC5/PSMD2/PSMC3/PSMD14/NDUFS4/MAOA/COX7A2/PSMD7/NDUFB2/NDUFS3/TUBA1C/PSMA7/UBA1/MAPK8/ITPR3/SDHA/SLC39A7/TUBA4A/HSPA5/DAXX/HTRA2/PLCG1/MFN1/MFN2/CASP3/GNAL/CALML4/EIF2AK3/SLC39A10/LRRK2/GNAS/ATP5F1E/PPIF/TUBB3/KLC2	-0.164812319906768
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/2701	21/9376	0.991801978103348	DPYD/ALDH2/PANK3/ALDH3A2/CSAD/BCAT2	-0.0239231917188293
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	23/2701	82/9376	0.973659258991701	DPYD/UPP1/UCK2/NME1/MGST2/MGST3/NME7/CDA/GSTO1/GUSB/CMPK1/GMPS/NME2/GSTM3/MGST1/GSTT2B/IMPDH1/CDADC1/RRM1/UCKL1/GSTO2/UCK1/GSTM2	-0.152389791765641
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	21/2701	75/9376	0.971965938541281	CREB5/ATP1A1/PLCB4/ADCY4/ALB/ASGR1/TTF1/SLC26A4/ATF2/CREB1/ITPR3/HSPA5/ATF6B/CREB3L2/GNAQ/TTF2/FXYD2/PLCB1/GNAS/ADCY6/ADCY1	-0.155050840886882
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	61/2701	217/9376	0.975805172004907	CREB5/RPS6KA2/AKT3/EPHX1/CCND3/MYC/RPS6KA3/AR/STAT3/HSP90AB1/PIK3CB/ADCY4/MAPK3/HSP90AA1/PTGES3/MGST2/PIK3R3/KPNB1/RELA/KPNA4/BCL6/STAT5B/MGST3/VEGFA/BCL2/KPNA1/GSTO1/ARRB1/STAT5A/AHR/MAPK1/GNAI3/ATF2/CREB1/RPS6KB1/FGF2/EGFR/MAP2K1/KPNA3/SOS2/HRAS/GSTM3/MTOR/ATF6B/MGST1/GSTT2B/CREB3L2/CACNA1C/PGR/EPHX2/AKT2/GNAS/ADCY6/RPS6KA6/DLL1/GSTO2/ESR2/EPHX4/GSTM2/JAK2/ADCY1	-0.229377424289045
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	15/2701	54/9376	0.964251923156033	CISD1/LDHA/MAT2A/BHMT2/MDH2/GCLC/MTR/GSS/MPST/GOT2/GOT1/BCAT2/KYAT1/CTH/CDO1	-0.167578117991771
Organismal Systems	Endocrine system	hsa04924	Renin secretion	19/2701	69/9376	0.955867123824241	PPP3CA/PPP3CC/PLCB4/AQP1/NPR1/GNAI3/CREB1/PPP3CB/ITPR3/CALML4/GNAQ/CACNA1C/PLCB1/GNAS/ADCY6/REN/KCNJ2/KCNMA1/EDN1	-0.234047612554004
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	19/2701	69/9376	0.955867123824241	CREB5/PPP3CA/PPP3CC/CAMK2D/MAOB/HDAC1/ATF2/CREB1/MAOA/PPP3CB/ATF6B/CREB3L2/CALML4/FOSB/GRIA1/CACNA1C/ARC/GNAS/STX1A	-0.234047612554004
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	6/2701	22/9376	0.946720070007741	ALDH2/MAOB/ALDH9A1/MAOA/ALDH3A2/CARNMT1	-0.159147052053926
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	69/2701	250/9376	0.958080710847834	OSBPL1A/NCOA7/VPS13A/OSBPL3/OSBPL5/IDS/AP2B1/BORCS7/ABCA5/OSBP/NPC1/ENTPD4/CTSH/AP3S1/OSBPL6/GUSB/CTSF/VPS26A/IGF2R/AP5Z1/CLTB/AP2A1/CLN8/HYAL1/DTNBP1/VPS39/AP3M2/STX17/RAB7A/GGA1/CLN5/RRAGC/LAPTM4B/RPTOR/OSTM1/TFE3/DNASE2/VPS13C/MTOR/OSBPL2/LITAF/PLEKHM1/HGSNAT/KXD1/TFEB/GLA/ATP6V0A2/HEXB/AP1G2/MEAK7/TPCN1/ARSG/RRAGB/DEPTOR/CLTCL1/ROGDI/BORCS8/AP4M1/SLC15A4/AKT1S1/IDUA/PPT2/LAMP3/TPCN2/ATP6V1E2/BLOC1S3/TLR3/ABCA2/HYAL3	-0.427332552458186
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	76/2701	275/9376	0.959343004274511	TUBB6/CREB5/RYR3/COX7A1/STIP1/PPP3CA/MCU/HSPA1A/HSPA1B/DDIT3/TUBB4B/PPP3CC/HSPA8/NDUFS7/KLC1/PIK3CB/TUBA1A/HSPA6/MAPK3/PSMB2/PIK3R3/EIF2S1/PSMD13/NDUFV1/PSMB3/ATP5MC1/CYCS/PSMB7/CSNK2B/COX6A1/NDUFC1/NDUFB1/PSMD11/MAPK1/NDUFA10/SEM1/PSMC5/PSMD2/PSMC3/PSMD14/ATF2/NDUFS4/NOTCH1/CREB1/COX7A2/PSMD7/NDUFB2/NDUFS3/TUBA1C/CSNK2A1/PPP3CB/PSMA7/MAPK8/ITPR3/SDHA/GSK3B/CSNK2A2/FYN/NCAM1/TUBA4A/HSPA5/ATF6B/CREB3L2/CASP3/RAC1/EIF2AK3/LAMC1/CACNA1C/IL6/MAPK12/MAPK11/ATP5F1E/PPIF/HSPA1L/TUBB3/KLC2	-0.435290680510738
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	10/2701	38/9376	0.913501821937294	INSR/ATP1A1/NR3C2/SCNN1B/PIK3CB/MAPK3/PIK3R3/MAPK1/NEDD4L/FXYD2	-0.339855356025055
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	25/2701	95/9376	0.913501821937294	HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/TGFB2/IL15/HLA-DMA/HLA-DRA/VEGFA/CXCL2/HLA-DQA1/HLA-DQA2/CXCL1/CSF1/HLA-DOA/ATP6V0A2/IL6/ICAM1/TGFB3/CXCL3/FLT1/IFNG/ATP6V1E2/HLA-DQB2	-0.539006089188587
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	13/2701	51/9376	0.884842941249065	PAFAH1B2/PLA2G4C/SELENOI/PAFAH1B1/CHPT1/PLPP1/PLA2G12A/PLA2G6/PAFAH2/PLD2/PLA2G4A/LPCAT4/PLPP2	-0.524533858524933
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/2701	17/9376	0.816778099614522	GLUD1/CA5B/CA13/CA8	-0.480960505850128
NA	NA	hsa03272	Virion - Hepatitis viruses	12/2701	48/9376	0.867826730840429	CD9/HSPG2/LDLR/CHMP4B/CLDN5/CHMP4A/TSG101/PDCD6IP/EGFR/VPS4A/CD81/CLDN12	-0.583972340068028
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	12/2701	48/9376	0.867826730840429	AKT3/ATP1A1/PIK3CB/PLCB4/HK1/PIK3R3/GNAT3/G6PC3/AKT2/FXYD2/PLCB1/HK2	-0.583972340068028
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	13/2701	52/9376	0.867826730840429	INSR/AKR1C3/LDLR/PLA2G4C/ADCY4/PTGS2/BMP6/HSD17B7/GNAS/ADCY6/IGF1R/PLA2G4A/ADCY1	-0.607948045517461
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	9/2701	37/9376	0.844371954331229	MAOB/MAOA/MIF/GOT2/GOT1/AOC3/LRTOMT/FAHD1/AOX1	-0.603338213985939
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	68/2701	254/9376	0.929326262947232	FLT4/ITPKC/NFATC1/SPHK1/RYR3/PLCE1/ATP2B4/ASPH/PDGFD/PPP3CA/MCU/PPP3CC/PDGFA/PLCB4/NFATC2/ADCY4/FGFR1/CAMK2D/PLCG2/STIM1/ATP2B1/PTK2B/VEGFA/ATP2A2/P2RX4/BDKRB2/NOS3/GNA14/OXTR/ORAI2/EDNRB/FGF2/PPP3CB/EGFR/VEGFC/MET/ITPR3/ITPKB/RET/CAMK1/GNA11/CD38/TFEB/PLCG1/PTGER3/GNAL/CALML4/GNAQ/CACNA1C/TPCN1/PDGFB/NOS1/PLCB1/GNAS/TACR1/PPIF/FLT1/CXCR4/BDKRB1/PLN/PLCD4/NGF/PLCD1/SPHK2/TPCN2/CHRM5/NTRK1/ADCY1	-0.726360428186242
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	12/2701	49/9376	0.850115981231441	CREB5/RELA/MAOB/GNAI3/ATF2/CREB1/MAOA/ATF6B/CREB3L2/GPSM1/FOSB/GNAS	-0.66912102438336
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/2701	18/9376	0.771401538524826	GBA2/MAN2C1/HEXB/MAN2B2	-0.617504789686645
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	29/2701	115/9376	0.875373050239042	APP/GNG12/GNB5/PLCB4/PLA2G4C/MAPK3/GNB1/BRAF/MAOB/PTGS2/CYP4X1/MAPK1/GNAI3/MAOA/MAP2K1/ITPR3/HRAS/GNG11/CASP3/GNAQ/ARAF/CACNA1C/PLCB1/GNAS/PLA2G4A/KCNN2/GNGT2/GNAO1/KCND2	-0.855370442734584
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	10/2701	43/9376	0.807280679851562	PLPP1/PLA2G12A/GOT2/SLC27A4/ACAT1/SLC27A1/APOB/DGAT1/APOA1/PLPP2	-0.805695884170803
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/2701	23/9376	0.754631939861243	ATP1A1/GLS/AQP1/GLUD1/FXYD2	-0.749426033552513
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	24/2701	100/9376	0.833113661606812	CCL14/CCL21/ACKR3/TNFRSF10B/TNFRSF10D/TNFRSF1A/CXCL2/TNFRSF14/LTBR/IL6R/TNFRSF10A/CX3CL1/CXCL1/CSF1/CCL23/TNFRSF10C/IL34/IL6/ACKR4/CXCL3/CXCR4/CCL16/CXCL13/IL18R1	-1.06724151659508
Organismal Systems	Digestive system	hsa04970	Salivary secretion	22/2701	93/9376	0.821169379719976	RYR3/ATP2B4/ATP1A1/PRKG1/PLCB4/ADCY4/VAMP2/ATP2B1/ITPR3/SLC12A2/CST3/CD38/CALML4/GNAQ/NOS1/FXYD2/PLCB1/GNAS/ADCY6/PRH1/KCNMA1/ADCY1	-1.10245653774521
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	5/2701	26/9376	0.667559023723407	PLA2G4C/PLA2G12A/PLA2G6/PLA2G4A/ACOX3	-1.07973632623041
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/2701	26/9376	0.667559023723407	TCN2/BTD/ABCD4/APOB/APOA1	-1.07973632623041
Human Diseases	Substance dependence	hsa05032	Morphine addiction	21/2701	91/9376	0.801070828468089	PDE7B/PDE2A/GNG12/GABBR1/PDE8A/GNB5/ADCY4/GRK5/GABRE/GNB1/ARRB1/GNAI3/PDE10A/PDE7A/GNG11/GNAS/ADCY6/GNGT2/GNAO1/GABRR2/ADCY1	-1.21297126136391
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/2701	39/9376	0.712062958638301	MTHFD1L/MAT2A/BHMT2/GART/MTR/DMGDH/CTH/AMT	-1.14616846989493
NA	NA	hsa04981	Folate transport and metabolism	6/2701	31/9376	0.671865856134526	BHMT2/ABCG2/MTR/ABCC4/FPGS/ABCC3	-1.16403198094816
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	20/2701	88/9376	0.788933391673118	TFPI/F8/CD55/PLAT/VWF/CD59/CLU/SERPING1/SERPINE1/CFI/THBD/CFH/PROCR/C1S/C1R/BDKRB2/F2RL3/C3/CFB/BDKRB1	-1.26538318604975
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	9/2701	44/9376	0.710040052505806	MAN2A1/DAD1/KRTCAP2/ALG13/MGAT4A/ST3GAL3/HEXB/B4GALT2/ALG11	-1.22630720778958
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	56/2701	226/9376	0.86014684826662	CREB5/NFATC1/PLCE1/AKT3/MYL9/ATP2B4/RAPGEF4/GABBR1/ATP1A1/VAV3/RAP1B/RRAS2/PIK3CB/ARAP3/ADCY4/TIAM1/MAPK3/PIK3R3/NFKBIA/CAMK2D/ROCK2/RELA/BRAF/ATP2B1/ATP2A2/NPR1/MAPK1/GNAI3/OXTR/CREB1/PDE10A/ROCK1/MAP2K1/MAPK8/ABCC4/RAP1A/CREBBP/EP300/CREB3L2/PTGER3/CALML4/RAC1/GRIA1/CACNA1C/PLD2/AKT2/FXYD2/GNAS/ADCY6/ACOX3/PLN/PTCH1/ADCY10/POPDC2/EDN1/ADCY1	-1.35374924026101
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	20/2701	89/9376	0.780068971541959	GNG12/SLC38A1/GABBR1/GABARAPL1/GNB5/GLS/ADCY4/GABRE/GNB1/GPHN/GABARAPL2/GNAI3/GNG11/SLC38A2/CACNA1C/ADCY6/GNGT2/GNAO1/GABRR2/ADCY1	-1.32606887303984
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	23/2701	102/9376	0.78274567879725	ATP2B4/RAB11A/ATP1A1/RAP1B/PLCB4/ADCY4/ATP2B1/ATP2A2/RAB8A/ITPR3/PLA2G12A/RAP1A/SLC12A2/CD38/RAC1/GNAQ/FXYD2/PLCB1/GNAS/ADCY6/KCNMA1/TPCN2/ADCY1	-1.40332175763334
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	35/2701	149/9376	0.815407666561477	GNG12/MGLL/GNB5/NDUFS7/PLCB4/ADCY4/MAPK3/GABRE/GNB1/NDUFV1/PTGS2/NDUFC1/NDUFB1/MAPK1/GNAI3/NDUFA10/DAGLB/NDUFS4/NDUFB2/NDUFS3/MAPK8/ITPR3/CNR1/GNG11/GNAQ/GRIA1/CACNA1C/MAPK12/MAPK11/PLCB1/ADCY6/GNGT2/GNAO1/GABRR2/ADCY1	-1.44477037863777
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/2701	24/9376	0.57855115389362	HS3ST1/NDST1/EXT1/HS3ST2	-1.31498420456977
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	13/2701	63/9376	0.716301428630196	AKR1C3/PLA2G4C/PTGIS/PTGES3/GGT5/PTGS2/PLA2G12A/PTGR1/PLA2G6/EPHX2/LTA4H/CYP2U1/PLA2G4A	-1.43715932561905
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	10/2701	51/9376	0.680648416345435	TJP2/PLCG2/KDELR1/SLC12A2/PLCG1/ATP6V0A2/ACTG1/GNAS/SEC61A2/ATP6V1E2	-1.45462831560047
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	15/2701	73/9376	0.71328224452638	MGST2/GSTK1/MAOB/MGST3/GSTO1/MAOA/GSTM3/MGST1/GSTT2B/GSTO2/FMO2/FMO4/FMO5/GSTM2/AOX1	-1.56432434112403
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/2701	31/9376	0.559888213445438	ALDH2/GUSB/ALDH9A1/UGDH/ALDH3A2	-1.56126451428283
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	6/2701	36/9376	0.57855115389362	GUSB/UGDH/FGGY/UGP2/XYLB/CRPPA	-1.61155442380212
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/2701	41/9376	0.592662157647123	MAOB/MAOA/AOC3/DMGDH/GCAT/CTH/AMT	-1.66269205332315
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	8/2701	46/9376	0.603705551888994	HEPH/GUSB/HMOX2/HMOX1/PPOX/FXN/HCCS/MMAB	-1.71387197521569
Organismal Systems	Digestive system	hsa04976	Bile secretion	18/2701	90/9376	0.694261384672344	EPHX1/ATP1A1/ABCB1/LDLR/AQP1/ADCY4/ABCG2/ABCC4/FXYD2/HMGCR/GNAS/ADCY6/ABCB4/KCNN2/SLC4A5/ABCC3/NCEH1/ADCY1	-1.85387097363995
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	41/2701	183/9376	0.777724501955357	REXO2/SNU13/NOP58/NXT1/XRN2/EIF6/NHP2/FBL/WDR43/GTPBP4/CSNK2B/NOP10/RAN/HEATR1/GNL2/RIOK1/FCF1/POP5/MDN1/GNL3/CSNK2A1/SBDS/WDR75/GNL3L/BMS1/IMP4/CSNK2A2/LSG1/EMG1/UTP4/UTP6/NOB1/UTP18/NAT10/EFL1/RPP38/RCL1/REXO5/RPP40/RMRP/POP1	-1.93157155903016
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	55/2701	238/9376	0.80219277640712	VWF/JAK1/RPS26/IKBKB/STAT3/PIK3CB/TBK1/MAPK3/CSF3/PIK3R3/NFKBIA/STAT1/PLCG2/RELA/ADAR/C1S/C1R/NFKBIB/IRF3/TNFRSF1A/RPS27L/MAPK1/TRAF3/MX1/ADAM17/IFNAR1/EIF2AK2/IL6R/OAS1/EGFR/MAPK8/IRAK4/ISG15/TRAF6/RPS28/IFIH1/C3/PLCG1/CGAS/OAS2/IL6/MAPK12/HBEGF/MAPK11/CFB/TYK2/RPSA/RPL35A/RPS5/RPS8/RPL36/RPS10-NUDT3/TLR3/RPS9/RPL34	-1.96619842650065
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	15/2701	79/9376	0.65910890949906	DNM3/AP2B1/VAMP2/STXBP1/STX2/UNC13B/CLTB/AP2A1/DNM2/CPLX1/ATP6V0A2/SLC1A1/CLTCL1/STX1A/ATP6V1E2	-1.93544162086635
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	46/2701	205/9376	0.778927407193361	TGFBR2/INSR/AKT3/COX7A1/PRKCZ/TGFB2/SMAD3/NDUFS7/PIK3CB/PLCB4/PIK3R3/CAMK2D/NDUFV1/RELA/SMAD2/ATP5MC1/MMP2/ATP2A2/COX6A1/NDUFC1/NDUFB1/NOS3/GAPDH/NDUFA10/NDUFS4/COX7A2/NDUFB2/NDUFS3/MAPK8/SDHA/GSK3B/MTOR/SP1/GYS1/PDHA1/RAC1/GFPT2/MAPK12/AKT2/MAPK11/PLCB1/ATP5F1E/TGFB3/PPIF/REN/PLN	-2.035756283238
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	14/2701	76/9376	0.639451275356106	ATP1A1/PLCB4/ADCY4/CAMK2D/GNAI3/ITPR3/CALML4/GNAQ/ACTG1/PLCB1/GNAS/ADCY6/KCNJ2/ADCY1	-2.00748163454606
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/2701	30/9376	0.462840923114896	PLA2G4C/PLA2G12A/PLA2G6/PLA2G4A	-1.87444608435886
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	12/2701	68/9376	0.612583574710891	ALDH1A1/DHRS3/RDH11/DHRS4L2/ALDH1A3/ALDH1A2/RDH10/RETSAT/DHRS4/DGAT1/RDH5/AOX1	-2.03951354468939
NA	NA	hsa04081	Hormone signaling	48/2701	219/9376	0.760834394161472	SMAD1/GNG12/INSR/RAMP3/RAPGEF4/STAT3/GHR/PRKG1/GNB5/ITGAV/PIK3CB/PLCB4/ADCY4/LEPR/PIK3R3/ITGB3/GNB1/STAT5B/PTHLH/HEPH/STAT5A/NPR1/GNA14/SMAD4/GNAI3/GNA12/OXTR/RAMP1/RAMP2/ADIPOR2/GNA11/GNG11/GNAQ/AVPR2/NOS1/THRB/PLCB1/GNAS/ADCY6/IGF1R/IRS2/ADRA2C/GNGT2/ESR2/GNAO1/MC1R/JAK2/ADCY1	-2.27806687956756
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/2701	28/9376	0.371925741788755	SLC12A7/ATP6V0A2/ATP6V1E2	-2.11715645598021
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	18/2701	99/9376	0.631146713338494	HLA-DRB1/CFI/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/CFH/HLA-DMA/HLA-DRA/C1S/C1R/HLA-DQA1/HLA-DQA2/HLA-DOA/C3/ICAM1/CFB/HLA-DQB2	-2.34687399043113
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/2701	23/9376	0.301852775944497	LNPEP/REN	-2.13234642138726
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/2701	29/9376	0.359100716209833	SLC24A1/GNB1/CALML4	-2.19874547725231
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	11/2701	70/9376	0.545491087956841	EPHX1/MGST2/GSTK1/MGST3/PTGS2/GSTO1/GSTM3/MGST1/GSTT2B/GSTO2/GSTM2	-2.42790782322862
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	65/2701	298/9376	0.757164261807086	CCL14/CCL21/TGFBR2/IL7/BMP2/ACKR3/RELL1/GHR/TGFB2/TNFRSF10B/OSMR/IL15/INHBB/CSF3/LEPR/IL4R/TNFRSF10D/CD40/IL3RA/TNFRSF11B/IL1R1/TNFRSF1A/IL15RA/CXCL2/CLCF1/TNFRSF14/LTBR/IFNAR1/IL6R/TNFRSF10A/CX3CL1/TNFRSF12A/ACVR1B/BMP6/CXCL1/CSF1/IL33/LIF/CCL23/TNFRSF10C/TNFRSF4/IL34/TNFSF9/IL6/IL32/ACKR4/BMPR2/TSLP/TGFB3/CXCL3/INHBA/CXCR4/TNFRSF21/GDF7/IL7R/CCL16/GDF11/TNFRSF18/CXCL13/IL11RA/NGF/TNFRSF6B/IFNG/IL18R1/IL17D	-2.70986677643397
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	71/2701	323/9376	0.763042698324093	SLC7A1/SHC1/CDKN1A/TNXB/THBS1/EFNA5/SOX4/ABCB1/MCL1/MYC/HOXD10/IKBKB/TNC/STAT3/FOXP1/TGFB2/RDX/PRKCE/HDAC4/GLS/PIK3CB/PDGFA/ITGA5/RECK/MAPK3/PIK3R3/ITGB3/PLCG2/EFNA1/PTGS2/ZEB1/VEGFA/BCL2/HDAC1/RASSF1/TIMP3/MAPK1/BCL2L11/NOTCH1/ROCK1/E2F3/DDIT4/ABL1/EGFR/RPTOR/MAP2K1/APC/MET/SOS2/HRAS/MTOR/HMOX1/EZH2/SLC45A3/CDC25B/CREBBP/MDM2/EP300/PLCG1/CASP3/MAPK7/PDGFB/VIM/HDAC5/BMPR2/IRS2/SPRY2/BRCA1/TP63/MMP16/CCNE2	-2.75675005545268
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/2701	26/9376	0.267023609489363	NR5A2/HES1	-2.3806368395607
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9/2701	66/9376	0.473360035003871	AKR1C3/CYP7B1/HSD17B12/HSD17B7/SRD5A3/DHRS11/LRTOMT/SRD5A1/RDH5	-2.73107254118062
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/2701	87/9376	0.518701034525314	COX7A1/ASPH/ATP1A1/TPM4/TPM2/CACNB2/ATP2A2/COX6A1/COX7A2/TPM3/CACNA1C/FXYD2/SLC9A7	-2.8688799038803
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	11/2701	79/9376	0.483346533632644	EPHX1/MGST2/GSTK1/MGST3/GSTO1/AKR7A2/GSTM3/MGST1/GSTT2B/GSTO2/GSTM2	-2.9333492433106
Human Diseases	Substance dependence	hsa05034	Alcoholism	36/2701	191/9376	0.654277744717392	GNG12/SHC1/CREB5/CAMKK2/GNB5/HDAC4/MAPK3/HDAC7/GNB1/BRAF/MAOB/HDAC1/MAPK1/GNAI3/ATF2/CREB1/MAOA/MAP2K1/SOS2/HRAS/ATF6B/GNG11/HDAC3/CREB3L2/CALML4/FOSB/ARAF/HDAC5/GNAS/PKIA/HDAC6/SHC2/HDAC10/CAMKK1/GNGT2/GNAO1	-3.0706246783743
NA	NA	hsa04382	Cornified envelope formation	40/2701	217/9376	0.639872243937644	S100A16/PPP2R1B/S100A10/ITGB4/DSP/JUP/LAMA3/S100A13/PCSK6/CLDN5/PLEC/PPP2R5C/ITGA6/UGCG/ELOVL1/PPP2R3A/KDSR/PPP2R5A/PPP2R5E/PPP2R2D/SPTLC1/PPP2CA/KAZN/PPP2R3C/COL4A5/PPP2CB/GBA2/SLC27A4/DST/PPP2R5B/PPP2R5D/PPL/TCHH/BLMH/EPHX2/S100A3/SLC27A1/CDSN/CLDN12/COL7A1	-3.41416674329445
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/2701	41/9376	0.253998067563052	GABRE/GRIA1/GABRR2	-3.04506813720511
Organismal Systems	Sensory system	hsa04742	Taste transduction	10/2701	86/9376	0.403640339925781	SCN3A/GABBR1/SCNN1B/PLCB4/ADCY4/ITPR3/GNAT3/CACNA1C/PLCB1/ADCY6	-3.5340437567874
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	13/2701	103/9376	0.438126116540799	COL18A1/COL8A1/ATP1A1/SLC3A2/COL4A5/COL12A1/SLC38A2/SLC1A1/COL27A1/FXYD2/COL6A3/COL5A3/COL7A1	-3.64728435542812
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	20/2701	143/9376	0.485497471798842	ACTN1/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/SNRPB/HLA-DMA/CD40/HLA-DRA/C1S/C1R/RO60/HLA-DQA1/HLA-DQA2/HLA-DOA/C3/TRIM21/IFNG/HLA-DQB2	-3.94372305559058
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	31/2701	195/9376	0.551848792944683	VWF/AKT3/CASP4/HDAC4/PIK3CB/PLCB4/MAPK3/HDAC7/PIK3R3/ITGB3/PLCG2/RELA/HDAC1/CLCN3/MAPK1/GSDMD/MAP2K1/MTOR/C3/HDAC3/PLCG1/RAC1/ACTG1/MAPK12/AKT2/MAPK11/HDAC5/PLCB1/PPIF/HDAC6/HDAC10	-4.02271419273632
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	18/2701	138/9376	0.452779163916746	COX7A1/NDUFS7/NDUFV1/ATP5MC1/CYCS/COX6A1/NDUFC1/NDUFB1/NDUFA10/NDUFS4/COX7A2/NDUFB2/NDUFS3/SDHA/ATP6V0A2/ATP5F1E/LHPP/ATP6V1E2	-4.11941441922396
NA	NA	hsa04082	Neuroactive ligand signaling	27/2701	199/9376	0.470981341360635	GNG12/GABBR1/GNB5/PLCB4/ADCY4/GABRE/GNB1/P2RX4/GNAI3/GNA11/GNG11/GNAL/GNAQ/GRIA1/SLC1A1/PLCB1/GNAS/ADCY6/TACR1/ADRA2C/GLRB/GNGT2/ACHE/CHRM5/GNAO1/GABRR2/ADCY1	-4.79810179545145
Genetic Information Processing	Translation	hsa03010	Ribosome	27/2701	222/9376	0.422185977165614	RPS26/MRPL18/MRPS6/RPS27L/DAP3/MRPS5/MRPS11/MRPL43/MRPL37/MRPL47/RPS28/MRPS25/MRPS27/MRPS10/MRPL21/MRPS30/MRPS2/MRPL50/MRPL45/RPSA/RPL35A/RPS5/RPS8/RPL36/RPS10-NUDT3/RPS9/RPL34	-5.54218994246018
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	35/2701	370/9376	0.328366871128811	CALCRL/GABBR1/ADM/GHR/LEPR/GABRE/P2RX4/BDKRB2/OXTR/F2RL3/EDNRB/CHRNA5/CNR1/LYPD6B/C3/PTGER3/RXFP1/GRIA1/AVPR2/THRB/NMB/TACR1/ADRA2C/GLRB/BDKRB1/NTS/GZMA/LYNX1/S1PR3/CHRM5/MC1R/EDN1/GABRR2/LTB4R/TMEM97	-8.38473412489406
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	9/2701	449/9376	0.0695807623836425	PDE2A/ANO2/PRKG1/CAMK2D/GNB1/ARRB1/NCALD/GNAL/CALML4	-12.852019617739