ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003712 transcription coregulator activity 250/5838 495/18639 0.505050505050505 1.61247625276402 1.92730254160872e-19 2.62305875912947e-16 GO:0031625 ubiquitin protein ligase binding 158/5838 302/18639 0.52317880794702 1.67035453945264 1.92441894117909e-14 1.06290154975041e-11 GO:0044389 ubiquitin-like protein ligase binding 166/5838 322/18639 0.515527950310559 1.64592762347354 2.34291304133081e-14 1.06290154975041e-11 GO:0003713 transcription coactivator activity 137/5838 256/18639 0.53515625 1.70859495439363 1.08653514803931e-13 3.69693584120375e-11 GO:0045296 cadherin binding 164/5838 334/18639 0.491017964071856 1.56767451735788 6.52366136675302e-12 1.77574062403017e-09 GO:0106310 protein serine kinase activity 174/5838 361/18639 0.481994459833795 1.53886514848272 1.08459663748177e-11 2.46022670602115e-09 GO:0141003 histone H2AX kinase activity 170/5838 354/18639 0.480225988700565 1.53321894542477 2.7210049732679e-11 5.29041109802517e-09 GO:0140996 histone H3 kinase activity 170/5838 357/18639 0.476190476190476 1.52033475260608 6.3627553795711e-11 1.08246375894953e-08 GO:0035173 histone kinase activity 170/5838 360/18639 0.472222222222222 1.50766529633436 1.45428271891306e-10 2.19919864493408e-08 GO:0140857 histone H3T45 kinase activity 123/5838 246/18639 0.5 1.59635149023638 6.57237789258526e-10 5.17320675645433e-08 GO:0035402 histone H3T11 kinase activity 123/5838 247/18639 0.497975708502024 1.58988852873745 9.08196666820297e-10 5.17320675645433e-08 GO:0004676 3-phosphoinositide-dependent protein kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:0004711 ribosomal protein S6 kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:0035175 histone H3S10 kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:0035979 histone H2AXS139 kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:0044022 histone H3S28 kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:0044023 histone H4S1 kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:0044024 histone H2AS1 kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:0044025 histone H2BS14 kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:0072354 histone H3T3 kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:0072371 histone H2AS121 kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:0072518 Rho-dependent protein serine/threonine kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:0140823 histone H2BS36 kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:0140855 histone H3S57 kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:0140995 histone H2A kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:0140997 histone H4 kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:0140998 histone H2B kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:1990244 histone H2AT120 kinase activity 122/5838 245/18639 0.497959183673469 1.58983576986807 1.06428941352477e-09 5.17320675645433e-08 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 121/5838 243/18639 0.497942386831276 1.58978214253994 1.24720415962826e-09 5.67083598283359e-08 GO:0004679 AMP-activated protein kinase activity 123/5838 248/18639 0.495967741935484 1.58347768789577 1.25000058401916e-09 5.67083598283359e-08 GO:0004677 DNA-dependent protein kinase activity 122/5838 246/18639 0.495934959349593 1.58337302283609 1.46477568901254e-09 6.43083778305183e-08 GO:0004674 protein serine/threonine kinase activity 194/5838 433/18639 0.448036951501155 1.43044891041967 1.84735576025718e-09 7.85703496784384e-08 GO:0035403 histone H3T6 kinase activity 122/5838 247/18639 0.493927125506073 1.57696260573958 2.0079968146722e-09 8.28146565081473e-08 GO:0060589 nucleoside-triphosphatase regulator activity 212/5838 490/18639 0.43265306122449 1.38133271808209 1.19203364468729e-08 4.77164056005705e-07 GO:0140297 DNA-binding transcription factor binding 211/5838 488/18639 0.432377049180328 1.38045149360605 1.37276657243955e-08 5.33810087168637e-07 GO:0030695 GTPase regulator activity 211/5838 489/18639 0.431492842535787 1.37762848441667 1.67447302023426e-08 6.33043827927451e-07 GO:0016887 ATP hydrolysis activity 184/5838 417/18639 0.441247002398082 1.40877061968103 1.94643785424274e-08 7.1597349179037e-07 GO:0051020 GTPase binding 145/5838 315/18639 0.46031746031746 1.46965692751921 2.55005469593304e-08 9.13322221359175e-07 GO:0004386 helicase activity 81/5838 155/18639 0.52258064516129 1.66844478334383 4.50019583660945e-08 1.57045295733986e-06 GO:0019902 phosphatase binding 95/5838 190/18639 0.5 1.59635149023638 5.57909019885522e-08 1.89828544016049e-06 GO:0031267 small GTPase binding 131/5838 283/18639 0.462897526501767 1.47789431251566 7.91989767438389e-08 2.62901969142353e-06 GO:0003714 transcription corepressor activity 100/5838 204/18639 0.490196078431373 1.5650504806239 8.93194399899202e-08 2.89437518634003e-06 GO:0140658 ATP-dependent chromatin remodeler activity 81/5838 158/18639 0.512658227848101 1.63676545201452 1.33082208869706e-07 4.21220665748071e-06 GO:0003779 actin binding 190/5838 443/18639 0.428893905191874 1.3693308494127 1.44132951498216e-07 4.45829424975162e-06 GO:0001221 transcription coregulator binding 63/5838 115/18639 0.547826086956522 1.74904598060682 1.48509963876335e-07 4.49160135190425e-06 GO:0019903 protein phosphatase binding 75/5838 144/18639 0.520833333333333 1.6628661356629 1.67146644026213e-07 4.91099494204569e-06 GO:0070063 RNA polymerase binding 38/5838 59/18639 0.644067796610169 2.05631717386381 1.69593506448308e-07 4.91099494204569e-06 GO:0004842 ubiquitin-protein transferase activity 191/5838 449/18639 0.425389755011136 1.35814313868663 2.68793549637624e-07 7.62141710535014e-06 GO:0140597 protein carrier chaperone 92/5838 188/18639 0.48936170212766 1.5623865649122 3.1715284086845e-07 8.61736688613134e-06 GO:0001098 basal transcription machinery binding 38/5838 60/18639 0.633333333333333 2.02204522096608 3.22913821596399e-07 8.61736688613134e-06 GO:0001099 basal RNA polymerase II transcription machinery binding 38/5838 60/18639 0.633333333333333 2.02204522096608 3.22913821596399e-07 8.61736688613134e-06 GO:0002039 p53 binding 42/5838 69/18639 0.608695652173913 1.94338442289647 3.8781770268774e-07 1.01503825645772e-05 GO:0019787 ubiquitin-like protein transferase activity 201/5838 479/18639 0.419624217118998 1.33973548867438 4.30500898244007e-07 1.10549381605678e-05 GO:0140097 catalytic activity, acting on DNA 148/5838 336/18639 0.44047619047619 1.40630964616062 5.23803564712402e-07 1.32017898439552e-05 GO:0008186 ATP-dependent activity, acting on RNA 46/5838 79/18639 0.582278481012658 1.85904224179427 6.84002263174562e-07 1.69259469123742e-05 GO:0061775 cohesin loader activity 77/5838 153/18639 0.503267973856209 1.60678516010721 7.00971597381022e-07 1.70361132863495e-05 GO:0003724 RNA helicase activity 45/5838 77/18639 0.584415584415584 1.86586537819837 7.81500354984859e-07 1.83372532640596e-05 GO:0000510 H3-H4 histone complex chaperone activity 76/5838 151/18639 0.503311258278146 1.60692335441013 8.21875421827799e-07 1.83372532640596e-05 GO:0140584 chromatin extrusion motor activity 76/5838 151/18639 0.503311258278146 1.60692335441013 8.21875421827799e-07 1.83372532640596e-05 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 76/5838 151/18639 0.503311258278146 1.60692335441013 8.21875421827799e-07 1.83372532640596e-05 GO:0140849 ATP-dependent H2AZ histone chaperone activity 76/5838 151/18639 0.503311258278146 1.60692335441013 8.21875421827799e-07 1.83372532640596e-05 GO:0140098 catalytic activity, acting on RNA 166/5838 387/18639 0.428940568475452 1.36947983141726 8.59729425986931e-07 1.88724475607776e-05 GO:0001222 transcription corepressor binding 32/5838 49/18639 0.653061224489796 2.08503051785976 1.00947927075537e-06 2.18079569444135e-05 GO:0008094 ATP-dependent activity, acting on DNA 99/5838 210/18639 0.471428571428571 1.50513140508002 1.05074425895697e-06 2.23447333818818e-05 GO:0043021 ribonucleoprotein complex binding 86/5838 177/18639 0.485875706214689 1.55125681537095 1.10946983141067e-06 2.32157989792605e-05 GO:0015616 DNA translocase activity 76/5838 152/18639 0.5 1.59635149023638 1.14287915621635e-06 2.32157989792605e-05 GO:0140674 ATP-dependent histone chaperone activity 76/5838 152/18639 0.5 1.59635149023638 1.14287915621635e-06 2.32157989792605e-05 GO:0003689 DNA clamp loader activity 79/5838 160/18639 0.49375 1.57639709660843 1.34504597199253e-06 2.6920699527674e-05 GO:0005085 guanyl-nucleotide exchange factor activity 106/5838 230/18639 0.460869565217391 1.47141963447875 1.70512140614696e-06 3.36329019386379e-05 GO:0016755 aminoacyltransferase activity 204/5838 496/18639 0.411290322580645 1.31312783874283 1.89131483722188e-06 3.67725641922711e-05 GO:0140104 molecular carrier activity 113/5838 249/18639 0.453815261044177 1.44889733651977 2.00256679320842e-06 3.83872310641783e-05 GO:0005525 GTP binding 161/5838 378/18639 0.425925925925926 1.35985497316433 2.07483773136403e-06 3.92201965609228e-05 GO:0003725 double-stranded RNA binding 43/5838 75/18639 0.573333333333333 1.83048304213772 2.76809385157656e-06 5.16078867396671e-05 GO:0000993 RNA polymerase II complex binding 25/5838 36/18639 0.694444444444444 2.21715484755053 2.88527594911416e-06 5.30656833343833e-05 GO:0042393 histone binding 111/5838 247/18639 0.449392712550607 1.43477745276306 4.31813535390856e-06 7.83597628889273e-05 GO:0048156 tau protein binding 28/5838 43/18639 0.651162790697674 2.07896938263343 5.22871852257627e-06 9.36353409108724e-05 GO:0032182 ubiquitin-like protein binding 61/5838 120/18639 0.508333333333333 1.62295734840699 6.40393981466413e-06 0.000113191715425427 GO:0019001 guanyl nucleotide binding 166/5838 400/18639 0.415 1.3249717368962 9.09318052818022e-06 0.000156655932896877 GO:0032561 guanyl ribonucleotide binding 166/5838 400/18639 0.415 1.3249717368962 9.09318052818022e-06 0.000156655932896877 GO:0140713 histone chaperone activity 78/5838 164/18639 0.475609756097561 1.51848068583461 9.34619683170359e-06 0.000159002173599357 GO:0043175 RNA polymerase core enzyme binding 27/5838 42/18639 0.642857142857143 2.05245191601821 1.10082014925829e-05 0.000184964965819818 GO:0015631 tubulin binding 160/5838 385/18639 0.415584415584416 1.3268376022744 1.19325563112834e-05 0.000198051330971423 GO:0042162 telomeric DNA binding 25/5838 38/18639 0.657894736842105 2.10046248715313 1.28196241288082e-05 0.000210210945051903 GO:0042054 histone methyltransferase activity 38/5838 67/18639 0.567164179104478 1.81078676504425 1.46221242536467e-05 0.000236913227490633 GO:0180051 translation factor activity 45/5838 84/18639 0.535714285714286 1.71037659668184 1.85415675440926e-05 0.000296883216794236 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 146/5838 349/18639 0.418338108882521 1.33562932707457 1.88411447576116e-05 0.000298172069943132 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 78/5838 167/18639 0.467065868263473 1.49120258968189 2.11224088276356e-05 0.000330432165682898 GO:0061659 ubiquitin-like protein ligase activity 154/5838 372/18639 0.413978494623656 1.32171037363657 2.19878710070413e-05 0.000340062414097537 GO:0061630 ubiquitin protein ligase activity 147/5838 353/18639 0.41643059490085 1.32953920149999 2.33878544975305e-05 0.000357650224394821 GO:0051010 microtubule plus-end binding 16/5838 21/18639 0.761904761904762 2.43253560416973 3.03255133884949e-05 0.000458589152463795 GO:0008135 translation factor activity, RNA binding 44/5838 83/18639 0.530120481927711 1.69251724266026 3.22221373112884e-05 0.000481915701985314 GO:0003924 GTPase activity 138/5838 331/18639 0.416918429003021 1.33109671089197 3.82525019329426e-05 0.000565887555768857 GO:0005096 GTPase activator activity 116/5838 271/18639 0.428044280442804 1.36661824994406 4.03240176612156e-05 0.000590118150934563 GO:0140938 histone H3 methyltransferase activity 28/5838 47/18639 0.595744680851064 1.90203581815399 5.82771798666829e-05 0.000843779168069739 GO:0008168 methyltransferase activity 90/5838 204/18639 0.441176470588235 1.40854543256151 7.67850556544113e-05 0.00110004695521741 GO:0051219 phosphoprotein binding 47/5838 93/18639 0.505376344086022 1.61351656002387 8.52975026626083e-05 0.00120926980337302 GO:0051082 unfolded protein binding 58/5838 121/18639 0.479338842975207 1.53038655262331 9.44030099708355e-05 0.00132456182031244 GO:0008017 microtubule binding 116/5838 276/18639 0.420289855072464 1.34186067295232 0.000102399904068033 0.00142210479016932 GO:0004713 protein tyrosine kinase activity 65/5838 140/18639 0.464285714285714 1.48232638379093 0.000122945120100357 0.0016901849339049 GO:0043130 ubiquitin binding 49/5838 100/18639 0.49 1.56442446043165 0.000163317814071307 0.00222275544951049 GO:0023026 MHC class II protein complex binding 18/5838 27/18639 0.666666666666667 2.12846865364851 0.000167439351902491 0.0022562867122702 GO:0042800 histone H3K4 methyltransferase activity 14/5838 19/18639 0.736842105263158 2.35251798561151 0.000180552554518817 0.00240913751666774 GO:0004725 protein tyrosine phosphatase activity 48/5838 98/18639 0.489795918367347 1.56377288839482 0.000191938782365491 0.00253620080387799 GO:0005484 SNAP receptor activity 22/5838 36/18639 0.611111111111111 1.95109626584447 0.000214962182237776 0.00280900661088906 GO:0016922 nuclear receptor binding 63/5838 137/18639 0.45985401459854 1.46817728299113 0.000216712486512381 0.00280900661088906 GO:0050660 flavin adenine dinucleotide binding 43/5838 86/18639 0.5 1.59635149023638 0.000227941392696356 0.00292668146660133 GO:0016741 transferase activity, transferring one-carbon groups 92/5838 215/18639 0.427906976744186 1.36617988001625 0.000242606699841624 0.00308586652789206 GO:0004860 protein kinase inhibitor activity 42/5838 84/18639 0.5 1.59635149023638 0.000268189471469843 0.00337944538194771 GO:0030515 snoRNA binding 20/5838 32/18639 0.625 1.99543936279548 0.000270653597819471 0.00337944538194771 GO:0051721 protein phosphatase 2A binding 19/5838 30/18639 0.633333333333333 2.02204522096608 0.000300836916940632 0.00372217312687455 GO:0140030 modification-dependent protein binding 76/5838 173/18639 0.439306358381503 1.40257471974526 0.000311498518212232 0.00379804450020805 GO:0000287 magnesium ion binding 97/5838 230/18639 0.421739130434783 1.34648777872112 0.000312550318900295 0.00379804450020805 GO:0019887 protein kinase regulator activity 106/5838 255/18639 0.415686274509804 1.32716280756907 0.000325123804478045 0.00391587166278424 GO:0016278 lysine N-methyltransferase activity 36/5838 70/18639 0.514285714285714 1.64196153281456 0.000358456424974691 0.00425485837210312 GO:0008276 protein methyltransferase activity 46/5838 95/18639 0.484210526315789 1.54594039054471 0.000359521464211506 0.00425485837210312 GO:0023023 MHC protein complex binding 22/5838 37/18639 0.594594594594595 1.89836393433516 0.000373920271745913 0.00438711629177748 GO:0050321 tau-protein kinase activity 15/5838 22/18639 0.681818181818182 2.17684294123143 0.000412968134994432 0.00480384300621728 GO:0061791 GTPase motor activity 23/5838 40/18639 0.575 1.83580421377184 0.000541796044481603 0.00619650770201228 GO:1990606 membrane scission GTPase motor activity 23/5838 40/18639 0.575 1.83580421377184 0.000541796044481603 0.00619650770201228 GO:0051117 ATPase binding 41/5838 84/18639 0.488095238095238 1.55834312142123 0.000597161674168946 0.00675437766493527 GO:0016279 protein-lysine N-methyltransferase activity 35/5838 69/18639 0.507246376811594 1.61948701908039 0.000600499410328558 0.00675437766493527 GO:0016791 phosphatase activity 111/5838 273/18639 0.406593406593407 1.29813198107134 0.000638859843039007 0.00712695283914827 GO:0031072 heat shock protein binding 59/5838 131/18639 0.450381679389313 1.43793493013659 0.000653056632558331 0.00722609818627552 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 109/5838 268/18639 0.406716417910448 1.29852471966989 0.00070154622392411 0.00770003557065091 GO:0035591 signaling adaptor activity 58/5838 129/18639 0.449612403100775 1.43547885943737 0.000760474000162392 0.00828004091376812 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 16/5838 25/18639 0.64 2.04332990750257 0.000768394743683527 0.00829988290597842 GO:0019210 kinase inhibitor activity 43/5838 90/18639 0.477777777777778 1.52540253511477 0.000782959484805129 0.00839061306157308 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 9/5838 11/18639 0.818181818181818 2.61221152947772 0.00082129804583653 0.00873270812799623 GO:0008170 N-methyltransferase activity 46/5838 98/18639 0.469387755102041 1.49861568471171 0.000846736017542384 0.00893339317732701 GO:0001217 DNA-binding transcription repressor activity 112/5838 278/18639 0.402877697841727 1.28626882666529 0.000896662244375601 0.00938736395842456 GO:0031994 insulin-like growth factor I binding 10/5838 13/18639 0.769230769230769 2.45592536959443 0.000951044109596085 0.00980584116030509 GO:0046975 histone H3K36 methyltransferase activity 10/5838 13/18639 0.769230769230769 2.45592536959443 0.000951044109596085 0.00980584116030509 GO:0005520 insulin-like growth factor binding 13/5838 19/18639 0.684210526315789 2.18448098663926 0.000971265542700727 0.00989400366631862 GO:0019207 kinase regulator activity 115/5838 287/18639 0.400696864111498 1.27930607231487 0.000974134086176852 0.00989400366631862 GO:0016776 phosphotransferase activity, phosphate group as acceptor 22/5838 39/18639 0.564102564102564 1.80101193770259 0.00101476680674226 0.0102303527701941 GO:0032452 histone demethylase activity 18/5838 30/18639 0.6 1.91562178828366 0.00109606589020619 0.0109687182100782 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 94/5838 229/18639 0.410480349344978 1.31054183477921 0.00111085700265787 0.0110355940191048 GO:0001046 core promoter sequence-specific DNA binding 24/5838 44/18639 0.545454545454545 1.74147435298514 0.00115744812484517 0.0114151224486541 GO:0035401 histone H3Y41 kinase activity 52/5838 115/18639 0.452173913043478 1.44365699986595 0.00118481319560914 0.0115180768516003 GO:0140801 histone H2AXY142 kinase activity 52/5838 115/18639 0.452173913043478 1.44365699986595 0.00118481319560914 0.0115180768516003 GO:0141052 histone H3 demethylase activity 17/5838 28/18639 0.607142857142857 1.93842680957275 0.00125014082659589 0.0120669621630993 GO:0035198 miRNA binding 23/5838 42/18639 0.547619047619048 1.74838496549699 0.00135793957527562 0.0129367830734101 GO:0031593 polyubiquitin modification-dependent protein binding 30/5838 59/18639 0.508474576271186 1.62340829515564 0.00136877058234464 0.0129367830734101 GO:0045309 protein phosphorylated amino acid binding 30/5838 59/18639 0.508474576271186 1.62340829515564 0.00136877058234464 0.0129367830734101 GO:0032451 demethylase activity 22/5838 40/18639 0.55 1.75598663926002 0.00159284218283861 0.0148483439098859 GO:0140662 ATP-dependent protein folding chaperone 22/5838 40/18639 0.55 1.75598663926002 0.00159284218283861 0.0148483439098859 GO:0004407 histone deacetylase activity 14/5838 22/18639 0.636363636363636 2.03172007848267 0.00178969660293157 0.0164579532202018 GO:0033558 protein lysine deacetylase activity 14/5838 22/18639 0.636363636363636 2.03172007848267 0.00178969660293157 0.0164579532202018 GO:0140457 protein demethylase activity 18/5838 31/18639 0.580645161290323 1.8538275370487 0.001852785344001 0.016923764115338 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 30/5838 60/18639 0.5 1.59635149023638 0.0019257116137098 0.0174726233750602 GO:0043022 ribosome binding 50/5838 112/18639 0.446428571428571 1.4253138305682 0.00203702053259422 0.0183601651977532 GO:0032395 MHC class II receptor activity 8/5838 10/18639 0.8 2.55416238437821 0.00216872233453713 0.0192917065183335 GO:0099122 RNA polymerase II C-terminal domain binding 8/5838 10/18639 0.8 2.55416238437821 0.00216872233453713 0.0192917065183335 GO:0140693 molecular condensate scaffold activity 25/5838 48/18639 0.520833333333333 1.6628661356629 0.00218662476779087 0.019324651356905 GO:0140296 general transcription initiation factor binding 27/5838 53/18639 0.509433962264151 1.6264713296748 0.00225396549292173 0.0197796231963736 GO:0003774 cytoskeletal motor activity 65/5838 153/18639 0.42483660130719 1.35637708320738 0.00227013961725955 0.0197796231963736 GO:0004721 phosphoprotein phosphatase activity 73/5838 175/18639 0.417142857142857 1.33181324328292 0.00228170524748762 0.0197796231963736 GO:0034450 ubiquitin-ubiquitin ligase activity 11/5838 16/18639 0.6875 2.19498329907503 0.00230691589980302 0.0198715983521007 GO:0017166 vinculin binding 9/5838 12/18639 0.75 2.39452723535457 0.00236754240261788 0.0201389075622684 GO:0035259 nuclear glucocorticoid receptor binding 9/5838 12/18639 0.75 2.39452723535457 0.00236754240261788 0.0201389075622684 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 41/5838 89/18639 0.460674157303371 1.47079575504925 0.00244574505303716 0.0205472778838492 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 41/5838 89/18639 0.460674157303371 1.47079575504925 0.00244574505303716 0.0205472778838492 GO:0003743 translation initiation factor activity 26/5838 51/18639 0.509803921568627 1.62765249984886 0.00266405474489332 0.0222440399251522 GO:0003684 damaged DNA binding 35/5838 74/18639 0.472972972972973 1.51006222049388 0.00286433268664324 0.0237704682104966 GO:0001223 transcription coactivator binding 23/5838 44/18639 0.522727272727273 1.66891292161076 0.00305174438205031 0.0251722672967907 GO:0060590 ATPase regulator activity 25/5838 49/18639 0.510204081632653 1.62893009207794 0.00315034806039949 0.0256759796460448 GO:0140793 histone H2AXY142 phosphatase activity 41/5838 90/18639 0.455555555555556 1.45445357999315 0.00315054268985267 0.0256759796460448 GO:0016779 nucleotidyltransferase activity 58/5838 136/18639 0.426470588235294 1.3615939181428 0.00341568798039108 0.0275074043864631 GO:0140789 histone phosphatase activity 58/5838 136/18639 0.426470588235294 1.3615939181428 0.00341568798039108 0.0275074043864631 GO:0140101 catalytic activity, acting on a tRNA 59/5838 139/18639 0.424460431654676 1.35517608523664 0.00359809752027097 0.0286484613121847 GO:0005178 integrin binding 67/5838 161/18639 0.416149068322981 1.32864037075575 0.00359947603555003 0.0286484613121847 GO:0044183 protein folding chaperone 35/5838 75/18639 0.466666666666667 1.48992805755396 0.00377413875578711 0.0298639700385248 GO:0051015 actin filament binding 84/5838 209/18639 0.401913875598086 1.28319162851537 0.00394000723502293 0.0308897870927194 GO:0017124 SH3 domain binding 50/5838 115/18639 0.434782608695652 1.38813173064033 0.00394917189870182 0.0308897870927194 GO:0061631 ubiquitin conjugating enzyme activity 19/5838 35/18639 0.542857142857143 1.73318161797093 0.00397943925262235 0.0309486675589658 GO:0019888 protein phosphatase regulator activity 47/5838 107/18639 0.439252336448598 1.40240224375906 0.00401643669761611 0.031058922417361 GO:0004715 non-membrane spanning protein tyrosine kinase activity 23/5838 45/18639 0.511111111111111 1.63182596779719 0.00441283715342795 0.0337408503697497 GO:0042605 peptide antigen binding 23/5838 45/18639 0.511111111111111 1.63182596779719 0.00441283715342795 0.0337408503697497 GO:0032183 SUMO binding 11/5838 17/18639 0.647058823529412 2.06586663442355 0.00469074409763483 0.0356653783065978 GO:0070412 R-SMAD binding 15/5838 26/18639 0.576923076923077 1.84194402719583 0.00479563777377718 0.0362603500561708 GO:0061980 regulatory RNA binding 28/5838 58/18639 0.482758620689655 1.54130488712478 0.00507477285611349 0.0381589273876821 GO:0051371 muscle alpha-actinin binding 10/5838 15/18639 0.666666666666667 2.12846865364851 0.00516342966062718 0.0386122404841406 GO:0046332 SMAD binding 36/5838 79/18639 0.455696202531646 1.45490262401291 0.00540967329703943 0.040232597580714 GO:0070325 lipoprotein particle receptor binding 17/5838 31/18639 0.548387096774194 1.75083711832377 0.00553385118478644 0.040864308690643 GO:0140852 histone ubiquitin ligase activity 9/5838 13/18639 0.692307692307692 2.21033283263499 0.00555466356191694 0.040864308690643 GO:0001091 RNA polymerase II general transcription initiation factor binding 14/5838 24/18639 0.583333333333333 1.86241007194245 0.00558714124411464 0.0408822539421507 GO:0008432 JUN kinase binding 8/5838 11/18639 0.727272727272727 2.32196580398019 0.00576185377107205 0.0411854557433581 GO:0042608 T cell receptor binding 8/5838 11/18639 0.727272727272727 2.32196580398019 0.00576185377107205 0.0411854557433581 GO:0140537 transcription regulator activator activity 8/5838 11/18639 0.727272727272727 2.32196580398019 0.00576185377107205 0.0411854557433581 GO:0048029 monosaccharide binding 34/5838 74/18639 0.459459459459459 1.46691758562262 0.00577448941883761 0.0411854557433581 GO:0000149 SNARE binding 46/5838 106/18639 0.433962264150943 1.38551261416743 0.00577988394341028 0.0411854557433581 GO:0019208 phosphatase regulator activity 50/5838 117/18639 0.427350427350427 1.36440298310802 0.00594628115844383 0.042150461753344 GO:0016407 acetyltransferase activity 42/5838 96/18639 0.4375 1.39680755395683 0.00685000169882644 0.0483049342595999 GO:0008173 RNA methyltransferase activity 31/5838 67/18639 0.462686567164179 1.47722078200979 0.00721994253920991 0.0506512463704366 GO:0019205 nucleobase-containing compound kinase activity 22/5838 44/18639 0.5 1.59635149023638 0.00740345003606803 0.0516722846107107 GO:0031418 L-ascorbic acid binding 12/5838 20/18639 0.6 1.91562178828366 0.00752022771002423 0.0522195403741989 GO:0051059 NF-kappaB binding 17/5838 32/18639 0.53125 1.69612345837616 0.00840066979830073 0.058037114697905 GO:0061733 protein-lysine-acetyltransferase activity 23/5838 47/18639 0.48936170212766 1.5623865649122 0.00865380204025905 0.0592856751561113 GO:0070064 proline-rich region binding 11/5838 18/18639 0.611111111111111 1.95109626584447 0.00866851532407505 0.0592856751561113 GO:0019213 deacetylase activity 19/5838 37/18639 0.513513513513513 1.63949612510764 0.00872913342755803 0.0594017529745324 GO:0005548 phospholipid transporter activity 31/5838 68/18639 0.455882352941176 1.45549694698023 0.00935249227796207 0.0633270745786387 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 10/5838 16/18639 0.625 1.99543936279548 0.00992428592866744 0.0652197679902578 GO:0140327 flippase activity 10/5838 16/18639 0.625 1.99543936279548 0.00992428592866744 0.0652197679902578 GO:0140328 floppase activity 10/5838 16/18639 0.625 1.99543936279548 0.00992428592866744 0.0652197679902578 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 53/5838 128/18639 0.4140625 1.321978577852 0.00994339050523744 0.0652197679902578 GO:0043995 histone H4K5 acetyltransferase activity 16/5838 30/18639 0.533333333333333 1.70277492291881 0.00996745903157503 0.0652197679902578 GO:0043996 histone H4K8 acetyltransferase activity 16/5838 30/18639 0.533333333333333 1.70277492291881 0.00996745903157503 0.0652197679902578 GO:0043997 histone H4K12 acetyltransferase activity 16/5838 30/18639 0.533333333333333 1.70277492291881 0.00996745903157503 0.0652197679902578 GO:0140303 intramembrane lipid transporter activity 22/5838 45/18639 0.488888888888889 1.56087701267557 0.0102640362716368 0.0668390113191279 GO:0010485 histone H4 acetyltransferase activity 18/5838 35/18639 0.514285714285714 1.64196153281456 0.0103737648664978 0.0672318761109688 GO:0051087 protein-folding chaperone binding 55/5838 134/18639 0.41044776119403 1.31043779049255 0.0107300555793109 0.069211401153754 GO:0003678 DNA helicase activity 33/5838 74/18639 0.445945945945946 1.42377295075137 0.0110795936898576 0.0705456894276138 GO:0034212 protein N-acetyltransferase activity 25/5838 53/18639 0.471698113207547 1.50599197192112 0.0112351490103624 0.0705456894276138 GO:0008174 mRNA methyltransferase activity 9/5838 14/18639 0.642857142857143 2.05245191601821 0.0112479166831684 0.0705456894276138 GO:0030983 mismatched DNA binding 9/5838 14/18639 0.642857142857143 2.05245191601821 0.0112479166831684 0.0705456894276138 GO:0032454 histone H3K9 demethylase activity 9/5838 14/18639 0.642857142857143 2.05245191601821 0.0112479166831684 0.0705456894276138 GO:0098847 sequence-specific single stranded DNA binding 9/5838 14/18639 0.642857142857143 2.05245191601821 0.0112479166831684 0.0705456894276138 GO:0036408 histone H3K14 acetyltransferase activity 15/5838 28/18639 0.535714285714286 1.71037659668184 0.011835588759809 0.0735535904205481 GO:0051393 alpha-actinin binding 15/5838 28/18639 0.535714285714286 1.71037659668184 0.011835588759809 0.0735535904205481 GO:0008080 N-acetyltransferase activity 31/5838 69/18639 0.449275362318841 1.43440278832834 0.0119753575983249 0.0740839167787278 GO:0071889 14-3-3 protein binding 17/5838 33/18639 0.515151515151515 1.6447257778193 0.0123406002322657 0.07518602472643 GO:0140416 transcription regulator inhibitor activity 17/5838 33/18639 0.515151515151515 1.6447257778193 0.0123406002322657 0.07518602472643 GO:0043531 ADP binding 19/5838 38/18639 0.5 1.59635149023638 0.0124082745379465 0.07518602472643 GO:0005078 MAP-kinase scaffold activity 8/5838 12/18639 0.666666666666667 2.12846865364851 0.0125504765079804 0.07518602472643 GO:0043047 single-stranded telomeric DNA binding 8/5838 12/18639 0.666666666666667 2.12846865364851 0.0125504765079804 0.07518602472643 GO:0019200 carbohydrate kinase activity 12/5838 21/18639 0.571428571428571 1.82440170312729 0.0125954545463821 0.07518602472643 GO:0035613 RNA stem-loop binding 12/5838 21/18639 0.571428571428571 1.82440170312729 0.0125954545463821 0.07518602472643 GO:0070182 DNA polymerase binding 12/5838 21/18639 0.571428571428571 1.82440170312729 0.0125954545463821 0.07518602472643 GO:0035091 phosphatidylinositol binding 107/5838 284/18639 0.376760563380282 1.20288457362882 0.0127356317033094 0.0756908067607168 GO:0005048 signal sequence binding 24/5838 51/18639 0.470588235294118 1.50244846139895 0.0132862369011423 0.0786198627063246 GO:0019783 ubiquitin-like protein peptidase activity 52/5838 127/18639 0.409448818897638 1.30724846444554 0.0135232670584262 0.0790430190043396 GO:0000182 rDNA binding 7/5838 10/18639 0.7 2.23489208633094 0.0136481333328581 0.0790430190043396 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 7/5838 10/18639 0.7 2.23489208633094 0.0136481333328581 0.0790430190043396 GO:0050815 phosphoserine residue binding 7/5838 10/18639 0.7 2.23489208633094 0.0136481333328581 0.0790430190043396 GO:0140999 histone H3K4 trimethyltransferase activity 7/5838 10/18639 0.7 2.23489208633094 0.0136481333328581 0.0790430190043396 GO:0030291 protein serine/threonine kinase inhibitor activity 22/5838 46/18639 0.478260869565217 1.52694490370437 0.0139499602509546 0.0804487114472423 GO:0050681 nuclear androgen receptor binding 14/5838 26/18639 0.538461538461538 1.7191477587161 0.0140654590603771 0.0807725307222498 GO:0061650 ubiquitin-like protein conjugating enzyme activity 20/5838 41/18639 0.48780487804878 1.5574160880355 0.0144741903169961 0.0827704748799651 GO:0005516 calmodulin binding 80/5838 207/18639 0.386473429951691 1.2338948716803 0.0146559099364956 0.0833349023625708 GO:0044390 ubiquitin-like protein conjugating enzyme binding 18/5838 36/18639 0.5 1.59635149023638 0.0147677155570903 0.0833349023625708 GO:0050145 nucleoside monophosphate kinase activity 11/5838 19/18639 0.578947368421053 1.84840698869476 0.0148178151151669 0.0833349023625708 GO:0140036 ubiquitin-modified protein reader activity 11/5838 19/18639 0.578947368421053 1.84840698869476 0.0148178151151669 0.0833349023625708 GO:0010484 histone H3 acetyltransferase activity 15/5838 29/18639 0.517241379310345 1.65139809334798 0.0175241602436319 0.0981478786418095 GO:0008175 tRNA methyltransferase activity 17/5838 34/18639 0.5 1.59635149023638 0.017595945913741 0.0981478786418095 GO:1990841 promoter-specific chromatin binding 30/5838 68/18639 0.441176470588235 1.40854543256151 0.0177390680122005 0.0985423329167546 GO:0001784 phosphotyrosine residue binding 22/5838 47/18639 0.468085106382979 1.49445671426385 0.0186105794763666 0.102963409216809 GO:0004402 histone acetyltransferase activity 20/5838 42/18639 0.476190476190476 1.52033475260608 0.0196449066031825 0.10706523112861 GO:0016881 acid-amino acid ligase activity 12/5838 22/18639 0.545454545454545 1.74147435298514 0.0199183052043716 0.10706523112861 GO:0061133 endopeptidase activator activity 12/5838 22/18639 0.545454545454545 1.74147435298514 0.0199183052043716 0.10706523112861 GO:0070034 telomerase RNA binding 12/5838 22/18639 0.545454545454545 1.74147435298514 0.0199183052043716 0.10706523112861 GO:0140035 ubiquitin-like protein reader activity 12/5838 22/18639 0.545454545454545 1.74147435298514 0.0199183052043716 0.10706523112861 GO:0031491 nucleosome binding 32/5838 74/18639 0.432432432432432 1.38062831588011 0.0202403686945371 0.10706523112861 GO:0000774 adenyl-nucleotide exchange factor activity 9/5838 15/18639 0.6 1.91562178828366 0.0203746472169802 0.10706523112861 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 9/5838 15/18639 0.6 1.91562178828366 0.0203746472169802 0.10706523112861 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 9/5838 15/18639 0.6 1.91562178828366 0.0203746472169802 0.10706523112861 GO:0031005 filamin binding 9/5838 15/18639 0.6 1.91562178828366 0.0203746472169802 0.10706523112861 GO:0120283 protein serine/threonine kinase binding 9/5838 15/18639 0.6 1.91562178828366 0.0203746472169802 0.10706523112861 GO:0141050 histone H3K deacetylase activity 9/5838 15/18639 0.6 1.91562178828366 0.0203746472169802 0.10706523112861 GO:0141051 histone H4K deacetylase activity 9/5838 15/18639 0.6 1.91562178828366 0.0203746472169802 0.10706523112861 GO:0042805 actinin binding 18/5838 37/18639 0.486486486486487 1.55320685536513 0.0204884775745419 0.107249299919045 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 14/5838 27/18639 0.518518518518518 1.6554756195044 0.0209247031043686 0.108634769903736 GO:0008408 3'-5' exonuclease activity 26/5838 58/18639 0.448275862068966 1.43121168090158 0.020938196001987 0.108634769903736 GO:0031369 translation initiation factor binding 16/5838 32/18639 0.5 1.59635149023638 0.0209926116713317 0.108634769903736 GO:0001216 DNA-binding transcription activator activity 175/5838 491/18639 0.356415478615071 1.13792876086096 0.0214042923076569 0.110345612995155 GO:0000049 tRNA binding 34/5838 80/18639 0.425 1.35689876670092 0.0226457283077208 0.116305042365313 GO:0004532 RNA exonuclease activity 19/5838 40/18639 0.475 1.51653391572456 0.0233418173620877 0.118982072770792 GO:0071949 FAD binding 19/5838 40/18639 0.475 1.51653391572456 0.0233418173620877 0.118982072770792 GO:0015095 magnesium ion transmembrane transporter activity 11/5838 20/18639 0.55 1.75598663926002 0.0237370886103413 0.119686225180404 GO:0140333 glycerophospholipid flippase activity 8/5838 13/18639 0.615384615384615 1.96474029567555 0.0237437772216819 0.119686225180404 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 8/5838 13/18639 0.615384615384615 1.96474029567555 0.0237437772216819 0.119686225180404 GO:1901981 phosphatidylinositol phosphate binding 71/5838 185/18639 0.383783783783784 1.2253076303436 0.0241335703201037 0.121202174190631 GO:0032266 phosphatidylinositol-3-phosphate binding 22/5838 48/18639 0.458333333333333 1.46332219938335 0.0244000243730998 0.121726716704292 GO:0000175 3'-5'-RNA exonuclease activity 17/5838 35/18639 0.485714285714286 1.5507414476582 0.0244168946805818 0.121726716704292 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 172/5838 484/18639 0.355371900826446 1.13459692694487 0.0249416281572811 0.123888890226495 GO:0050840 extracellular matrix binding 29/5838 67/18639 0.432835820895522 1.38191621542851 0.0258682792333345 0.128024465587521 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 7/5838 11/18639 0.636363636363636 2.03172007848267 0.0274491225659835 0.128361063770914 GO:0002162 dystroglycan binding 7/5838 11/18639 0.636363636363636 2.03172007848267 0.0274491225659835 0.128361063770914 GO:0004143 ATP-dependent diacylglycerol kinase activity 7/5838 11/18639 0.636363636363636 2.03172007848267 0.0274491225659835 0.128361063770914 GO:0008526 phosphatidylinositol transfer activity 7/5838 11/18639 0.636363636363636 2.03172007848267 0.0274491225659835 0.128361063770914 GO:0034511 U3 snoRNA binding 7/5838 11/18639 0.636363636363636 2.03172007848267 0.0274491225659835 0.128361063770914 GO:0034713 type I transforming growth factor beta receptor binding 7/5838 11/18639 0.636363636363636 2.03172007848267 0.0274491225659835 0.128361063770914 GO:0043522 leucine zipper domain binding 7/5838 11/18639 0.636363636363636 2.03172007848267 0.0274491225659835 0.128361063770914 GO:0070990 snRNP binding 7/5838 11/18639 0.636363636363636 2.03172007848267 0.0274491225659835 0.128361063770914 GO:0180030 inositol phosphate kinase activity 7/5838 11/18639 0.636363636363636 2.03172007848267 0.0274491225659835 0.128361063770914 GO:0033192 calmodulin-dependent protein phosphatase activity 34/5838 81/18639 0.419753086419753 1.34014693007499 0.0275396257318934 0.128361063770914 GO:0140791 histone H2AXS140 phosphatase activity 34/5838 81/18639 0.419753086419753 1.34014693007499 0.0275396257318934 0.128361063770914 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 34/5838 81/18639 0.419753086419753 1.34014693007499 0.0275396257318934 0.128361063770914 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 34/5838 81/18639 0.419753086419753 1.34014693007499 0.0275396257318934 0.128361063770914 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 34/5838 81/18639 0.419753086419753 1.34014693007499 0.0275396257318934 0.128361063770914 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 34/5838 81/18639 0.419753086419753 1.34014693007499 0.0275396257318934 0.128361063770914 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 34/5838 81/18639 0.419753086419753 1.34014693007499 0.0275396257318934 0.128361063770914 GO:1990439 MAP kinase serine/threonine phosphatase activity 34/5838 81/18639 0.419753086419753 1.34014693007499 0.0275396257318934 0.128361063770914 GO:0042578 phosphoric ester hydrolase activity 131/5838 363/18639 0.360881542699725 1.15218757697502 0.0284726085159316 0.132256724198576 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 12/5838 23/18639 0.521739130434783 1.6657580767684 0.0299807838815317 0.136879970622671 GO:0042171 lysophosphatidic acid acyltransferase activity 12/5838 23/18639 0.521739130434783 1.6657580767684 0.0299807838815317 0.136879970622671 GO:0044013 histone H2B acetyltransferase activity 12/5838 23/18639 0.521739130434783 1.6657580767684 0.0299807838815317 0.136879970622671 GO:0071617 lysophospholipid acyltransferase activity 12/5838 23/18639 0.521739130434783 1.6657580767684 0.0299807838815317 0.136879970622671 GO:0051019 mitogen-activated protein kinase binding 14/5838 28/18639 0.5 1.59635149023638 0.0300138174489281 0.136879970622671 GO:0120013 lipid transfer activity 28/5838 65/18639 0.430769230769231 1.37531820697288 0.0301719259271134 0.136879970622671 GO:0160215 deacylase activity 28/5838 65/18639 0.430769230769231 1.37531820697288 0.0301719259271134 0.136879970622671 GO:0017022 myosin binding 32/5838 76/18639 0.421052631578947 1.34429599177801 0.030414164762645 0.137520525720797 GO:0001727 lipid kinase activity 19/5838 41/18639 0.463414634146341 1.47954528363372 0.0310002225373941 0.139627552865918 GO:0016504 peptidase activator activity 25/5838 57/18639 0.43859649122807 1.40030832476876 0.0310853405719127 0.139627552865918 GO:0030145 manganese ion binding 29/5838 68/18639 0.426470588235294 1.3615939181428 0.0319130773208445 0.142405567979244 GO:0032934 sterol binding 29/5838 68/18639 0.426470588235294 1.3615939181428 0.0319130773208445 0.142405567979244 GO:0042826 histone deacetylase binding 50/5838 127/18639 0.393700787401575 1.25696967735148 0.0327680976310332 0.145743074757635 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 34/5838 82/18639 0.414634146341463 1.32380367483017 0.033215253255041 0.146772596363996 GO:0033549 MAP kinase phosphatase activity 34/5838 82/18639 0.414634146341463 1.32380367483017 0.033215253255041 0.146772596363996 GO:0005543 phospholipid binding 175/5838 497/18639 0.352112676056338 1.12419119030731 0.033374815543869 0.147000401149533 GO:0004707 MAP kinase activity 9/5838 16/18639 0.5625 1.79589542651593 0.0338108260162395 0.147488891692635 GO:0070411 I-SMAD binding 9/5838 16/18639 0.5625 1.79589542651593 0.0338108260162395 0.147488891692635 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 9/5838 16/18639 0.5625 1.79589542651593 0.0338108260162395 0.147488891692635 GO:0043014 alpha-tubulin binding 20/5838 44/18639 0.454545454545455 1.45122862748762 0.0341209263696602 0.14836607280865 GO:0070273 phosphatidylinositol-4-phosphate binding 15/5838 31/18639 0.483870967741935 1.54485628087392 0.034816068381507 0.150906589386086 GO:0050750 low-density lipoprotein particle receptor binding 13/5838 26/18639 0.5 1.59635149023638 0.0359832460802591 0.153562125253378 GO:0070006 metalloaminopeptidase activity 13/5838 26/18639 0.5 1.59635149023638 0.0359832460802591 0.153562125253378 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 11/5838 21/18639 0.523809523809524 1.67236822786669 0.0359928860806963 0.153562125253378 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 11/5838 21/18639 0.523809523809524 1.67236822786669 0.0359928860806963 0.153562125253378 GO:0009931 calcium-dependent protein serine/threonine kinase activity 11/5838 21/18639 0.523809523809524 1.67236822786669 0.0359928860806963 0.153562125253378 GO:0008374 O-acyltransferase activity 24/5838 55/18639 0.436363636363636 1.39317948238812 0.0364377585668139 0.15497434190448 GO:1990518 single-stranded 3'-5' DNA helicase activity 21/5838 47/18639 0.446808510638298 1.42652686361549 0.0371145092546136 0.157360894378595 GO:0016410 N-acyltransferase activity 38/5838 94/18639 0.404255319148936 1.29066716231878 0.0382709171266444 0.161759994439016 GO:0030332 cyclin binding 16/5838 34/18639 0.470588235294118 1.50244846139895 0.0393932237919743 0.165988165885068 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 34/5838 83/18639 0.409638554216867 1.30785423296475 0.0397425934851118 0.166639704209894 GO:0051879 Hsp90 protein binding 19/5838 42/18639 0.452380952380952 1.44431801497577 0.0403807009178296 0.166639704209894 GO:0004705 JUN kinase activity 8/5838 14/18639 0.571428571428571 1.82440170312729 0.0404049246063666 0.166639704209894 GO:0005161 platelet-derived growth factor receptor binding 8/5838 14/18639 0.571428571428571 1.82440170312729 0.0404049246063666 0.166639704209894 GO:0008191 metalloendopeptidase inhibitor activity 8/5838 14/18639 0.571428571428571 1.82440170312729 0.0404049246063666 0.166639704209894 GO:0046030 inositol trisphosphate phosphatase activity 8/5838 14/18639 0.571428571428571 1.82440170312729 0.0404049246063666 0.166639704209894 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 8/5838 14/18639 0.571428571428571 1.82440170312729 0.0404049246063666 0.166639704209894 GO:0004722 protein serine/threonine phosphatase activity 41/5838 103/18639 0.398058252427184 1.27088176892605 0.0416085711024976 0.17082530353606 GO:0043236 laminin binding 14/5838 29/18639 0.482758620689655 1.54130488712478 0.0416708308405377 0.17082530353606 GO:0005319 lipid transporter activity 67/5838 178/18639 0.376404494382022 1.20174775107683 0.0420354919545827 0.171802716366928 GO:0008234 cysteine-type peptidase activity 70/5838 187/18639 0.374331550802139 1.19512945793098 0.0431814525425144 0.173895612119699 GO:0043998 histone H2A acetyltransferase activity 12/5838 24/18639 0.5 1.59635149023638 0.0432313897781626 0.173895612119699 GO:0140033 acetylation-dependent protein binding 12/5838 24/18639 0.5 1.59635149023638 0.0432313897781626 0.173895612119699 GO:0046527 glucosyltransferase activity 10/5838 19/18639 0.526315789473684 1.68036998972251 0.0433141899401749 0.173895612119699 GO:0046624 sphingolipid transporter activity 10/5838 19/18639 0.526315789473684 1.68036998972251 0.0433141899401749 0.173895612119699 GO:1990380 K48-linked deubiquitinase activity 10/5838 19/18639 0.526315789473684 1.68036998972251 0.0433141899401749 0.173895612119699 GO:0101005 deubiquitinase activity 45/5838 115/18639 0.391304347826087 1.2493185575763 0.0455075436050188 0.18216402013656 GO:0016879 ligase activity, forming carbon-nitrogen bonds 21/5838 48/18639 0.4375 1.39680755395683 0.0470035530513465 0.183648424612354 GO:0036121 double-stranded DNA helicase activity 21/5838 48/18639 0.4375 1.39680755395683 0.0470035530513465 0.183648424612354 GO:0043138 3'-5' DNA helicase activity 21/5838 48/18639 0.4375 1.39680755395683 0.0470035530513465 0.183648424612354 GO:0120015 sterol transfer activity 15/5838 32/18639 0.46875 1.49657952209661 0.0470132360669558 0.183648424612354 GO:0004527 exonuclease activity 34/5838 84/18639 0.404761904761905 1.29228453971517 0.0471888548959228 0.183648424612354 GO:0017018 myosin phosphatase activity 34/5838 84/18639 0.404761904761905 1.29228453971517 0.0471888548959228 0.183648424612354 GO:0004177 aminopeptidase activity 18/5838 40/18639 0.45 1.43671634121274 0.047815816993621 0.183648424612354 GO:0000995 RNA polymerase III general transcription initiation factor activity 7/5838 12/18639 0.583333333333333 1.86241007194245 0.0483072270471879 0.183648424612354 GO:0005095 GTPase inhibitor activity 7/5838 12/18639 0.583333333333333 1.86241007194245 0.0483072270471879 0.183648424612354 GO:0005527 macrolide binding 7/5838 12/18639 0.583333333333333 1.86241007194245 0.0483072270471879 0.183648424612354 GO:0016801 hydrolase activity, acting on ether bonds 7/5838 12/18639 0.583333333333333 1.86241007194245 0.0483072270471879 0.183648424612354 GO:0016803 ether hydrolase activity 7/5838 12/18639 0.583333333333333 1.86241007194245 0.0483072270471879 0.183648424612354 GO:0031543 peptidyl-proline dioxygenase activity 7/5838 12/18639 0.583333333333333 1.86241007194245 0.0483072270471879 0.183648424612354 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 7/5838 12/18639 0.583333333333333 1.86241007194245 0.0483072270471879 0.183648424612354 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 7/5838 12/18639 0.583333333333333 1.86241007194245 0.0483072270471879 0.183648424612354 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 7/5838 12/18639 0.583333333333333 1.86241007194245 0.0483072270471879 0.183648424612354 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 7/5838 12/18639 0.583333333333333 1.86241007194245 0.0483072270471879 0.183648424612354 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 7/5838 12/18639 0.583333333333333 1.86241007194245 0.0483072270471879 0.183648424612354 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 13/5838 27/18639 0.481481481481481 1.53722736096837 0.049966178843586 0.186236582998281 GO:0004518 nuclease activity 77/5838 209/18639 0.368421052631579 1.17625899280576 0.0503512391345757 0.186236582998281 GO:0004712 protein serine/threonine/tyrosine kinase activity 19/5838 43/18639 0.441860465116279 1.41072922392983 0.0516600237819535 0.186236582998281 GO:0030295 protein kinase activator activity 53/5838 139/18639 0.381294964028777 1.21736156809393 0.0516865394326972 0.186236582998281 GO:0140767 enzyme-substrate adaptor activity 53/5838 139/18639 0.381294964028777 1.21736156809393 0.0516865394326972 0.186236582998281 GO:0140566 histone reader activity 16/5838 35/18639 0.457142857142857 1.45952136250184 0.0520048693594625 0.186236582998281 GO:0008649 rRNA methyltransferase activity 11/5838 22/18639 0.5 1.59635149023638 0.0520674669570211 0.186236582998281 GO:0031683 G-protein beta/gamma-subunit complex binding 11/5838 22/18639 0.5 1.59635149023638 0.0520674669570211 0.186236582998281 GO:0032931 histone H3K56 acetyltransferase activity 11/5838 22/18639 0.5 1.59635149023638 0.0520674669570211 0.186236582998281 GO:0043992 histone H3K9 acetyltransferase activity 11/5838 22/18639 0.5 1.59635149023638 0.0520674669570211 0.186236582998281 GO:0043993 histone H3K18 acetyltransferase activity 11/5838 22/18639 0.5 1.59635149023638 0.0520674669570211 0.186236582998281 GO:0043994 histone H3K23 acetyltransferase activity 11/5838 22/18639 0.5 1.59635149023638 0.0520674669570211 0.186236582998281 GO:0043999 histone H2AK5 acetyltransferase activity 11/5838 22/18639 0.5 1.59635149023638 0.0520674669570211 0.186236582998281 GO:0044012 histone H2AK9 acetyltransferase activity 11/5838 22/18639 0.5 1.59635149023638 0.0520674669570211 0.186236582998281 GO:0044014 histone H2BK5 acetyltransferase activity 11/5838 22/18639 0.5 1.59635149023638 0.0520674669570211 0.186236582998281 GO:0044015 histone H2BK12 acetyltransferase activity 11/5838 22/18639 0.5 1.59635149023638 0.0520674669570211 0.186236582998281 GO:0044016 histone H3K4 acetyltransferase activity 11/5838 22/18639 0.5 1.59635149023638 0.0520674669570211 0.186236582998281 GO:0044017 histone H3K27 acetyltransferase activity 11/5838 22/18639 0.5 1.59635149023638 0.0520674669570211 0.186236582998281 GO:0044018 histone H3K36 acetyltransferase activity 11/5838 22/18639 0.5 1.59635149023638 0.0520674669570211 0.186236582998281 GO:0046972 histone H4K16 acetyltransferase activity 11/5838 22/18639 0.5 1.59635149023638 0.0520674669570211 0.186236582998281 GO:0140908 histone H3K122 acetyltransferase activity 11/5838 22/18639 0.5 1.59635149023638 0.0520674669570211 0.186236582998281 GO:0031489 myosin V binding 9/5838 17/18639 0.529411764705882 1.69025451907382 0.0522721342434557 0.186236582998281 GO:0048038 quinone binding 9/5838 17/18639 0.529411764705882 1.69025451907382 0.0522721342434557 0.186236582998281 GO:0070403 NAD+ binding 9/5838 17/18639 0.529411764705882 1.69025451907382 0.0522721342434557 0.186236582998281 GO:0017069 snRNA binding 23/5838 54/18639 0.425925925925926 1.35985497316433 0.052934013153476 0.188102328725537 GO:0019209 kinase activator activity 56/5838 148/18639 0.378378378378378 1.2080497763951 0.053533811269497 0.18973832587965 GO:0140272 exogenous protein binding 33/5838 82/18639 0.402439024390244 1.28486827262928 0.0540813777424523 0.191181182097345 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 20/5838 46/18639 0.434782608695652 1.38813173064033 0.0552685205082403 0.193531049894056 GO:0001968 fibronectin binding 14/5838 30/18639 0.466666666666667 1.48992805755396 0.0561870540522805 0.193531049894056 GO:0016769 transferase activity, transferring nitrogenous groups 14/5838 30/18639 0.466666666666667 1.48992805755396 0.0561870540522805 0.193531049894056 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 17/5838 38/18639 0.447368421052632 1.42831449126413 0.0566539053346522 0.193531049894056 GO:0004843 cysteine-type deubiquitinase activity 42/5838 108/18639 0.388888888888889 1.2416067146283 0.0570910547606709 0.193531049894056 GO:0001094 TFIID-class transcription factor complex binding 6/5838 10/18639 0.6 1.91562178828366 0.0577322602916876 0.193531049894056 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 6/5838 10/18639 0.6 1.91562178828366 0.0577322602916876 0.193531049894056 GO:0004445 inositol-polyphosphate 5-phosphatase activity 6/5838 10/18639 0.6 1.91562178828366 0.0577322602916876 0.193531049894056 GO:0005522 profilin binding 6/5838 10/18639 0.6 1.91562178828366 0.0577322602916876 0.193531049894056 GO:0005528 FK506 binding 6/5838 10/18639 0.6 1.91562178828366 0.0577322602916876 0.193531049894056 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 6/5838 10/18639 0.6 1.91562178828366 0.0577322602916876 0.193531049894056 GO:0016427 tRNA (cytidine) methyltransferase activity 6/5838 10/18639 0.6 1.91562178828366 0.0577322602916876 0.193531049894056 GO:0030957 Tat protein binding 6/5838 10/18639 0.6 1.91562178828366 0.0577322602916876 0.193531049894056 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 6/5838 10/18639 0.6 1.91562178828366 0.0577322602916876 0.193531049894056 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 6/5838 10/18639 0.6 1.91562178828366 0.0577322602916876 0.193531049894056 GO:0070739 protein-glutamic acid ligase activity 6/5838 10/18639 0.6 1.91562178828366 0.0577322602916876 0.193531049894056 GO:0070740 tubulin-glutamic acid ligase activity 6/5838 10/18639 0.6 1.91562178828366 0.0577322602916876 0.193531049894056 GO:0098505 G-rich strand telomeric DNA binding 6/5838 10/18639 0.6 1.91562178828366 0.0577322602916876 0.193531049894056 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 6/5838 10/18639 0.6 1.91562178828366 0.0577322602916876 0.193531049894056 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 6/5838 10/18639 0.6 1.91562178828366 0.0577322602916876 0.193531049894056 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 6/5838 10/18639 0.6 1.91562178828366 0.0577322602916876 0.193531049894056 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 25/5838 60/18639 0.416666666666667 1.33029290853032 0.0582211490273407 0.194690377951378 GO:0035254 glutamate receptor binding 21/5838 49/18639 0.428571428571429 1.36830127734547 0.0586518294486326 0.195649852646051 GO:1990782 protein tyrosine kinase binding 45/5838 117/18639 0.384615384615385 1.22796268479722 0.0599688351374516 0.198811587314906 GO:0004709 MAP kinase kinase kinase activity 12/5838 25/18639 0.48 1.53249743062693 0.0600378856623266 0.198811587314906 GO:0019211 phosphatase activator activity 12/5838 25/18639 0.48 1.53249743062693 0.0600378856623266 0.198811587314906 GO:0005080 protein kinase C binding 22/5838 52/18639 0.423076923076923 1.35075895327694 0.0618217813653131 0.203727468373344 GO:0030159 signaling receptor complex adaptor activity 22/5838 52/18639 0.423076923076923 1.35075895327694 0.0618217813653131 0.203727468373344 GO:0052745 inositol phosphate phosphatase activity 10/5838 20/18639 0.5 1.59635149023638 0.0628912912700087 0.2065869739433 GO:0042809 nuclear vitamin D receptor binding 8/5838 15/18639 0.533333333333333 1.70277492291881 0.0632966701942367 0.2065869739433 GO:0061578 K63-linked deubiquitinase activity 8/5838 15/18639 0.533333333333333 1.70277492291881 0.0632966701942367 0.2065869739433 GO:0140776 protein-containing complex destabilizing activity 8/5838 15/18639 0.533333333333333 1.70277492291881 0.0632966701942367 0.2065869739433 GO:0005518 collagen binding 29/5838 72/18639 0.402777777777778 1.28594981157931 0.0671071027894816 0.217430985153997 GO:0045499 chemorepellent activity 13/5838 28/18639 0.464285714285714 1.48232638379093 0.067258225385623 0.217430985153997 GO:0046966 nuclear thyroid hormone receptor binding 13/5838 28/18639 0.464285714285714 1.48232638379093 0.067258225385623 0.217430985153997 GO:0051959 dynein light intermediate chain binding 13/5838 28/18639 0.464285714285714 1.48232638379093 0.067258225385623 0.217430985153997 GO:0017116 single-stranded DNA helicase activity 24/5838 58/18639 0.413793103448276 1.32111847467839 0.0675708705300096 0.217924063486595 GO:0043495 protein-membrane adaptor activity 20/5838 47/18639 0.425531914893617 1.35859701296713 0.0687159362516677 0.220571672732358 GO:0061749 forked DNA-dependent helicase activity 20/5838 47/18639 0.425531914893617 1.35859701296713 0.0687159362516677 0.220571672732358 GO:0019003 GDP binding 30/5838 75/18639 0.4 1.27708119218911 0.0690203742524334 0.221027598488381 GO:0003697 single-stranded DNA binding 46/5838 121/18639 0.380165289256198 1.21375485208056 0.0691847769903495 0.221033994093582 GO:0015605 organophosphate ester transmembrane transporter activity 21/5838 50/18639 0.42 1.34093525179856 0.0721748364169769 0.228880930749074 GO:0070577 lysine-acetylated histone binding 11/5838 23/18639 0.478260869565217 1.52694490370437 0.0723135931095531 0.228880930749074 GO:0140102 catalytic activity, acting on a rRNA 11/5838 23/18639 0.478260869565217 1.52694490370437 0.0723135931095531 0.228880930749074 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 11/5838 23/18639 0.478260869565217 1.52694490370437 0.0723135931095531 0.228880930749074 GO:0001618 virus receptor activity 32/5838 81/18639 0.395061728395062 1.26131475771764 0.0725248698454373 0.229017048398237 GO:0051018 protein kinase A binding 22/5838 53/18639 0.415094339622642 1.32527293529058 0.0753861455352249 0.237501259429262 GO:0000900 mRNA regulatory element binding translation repressor activity 9/5838 18/18639 0.5 1.59635149023638 0.0762281705598988 0.239047327493139 GO:0008525 phosphatidylcholine transporter activity 9/5838 18/18639 0.5 1.59635149023638 0.0762281705598988 0.239047327493139 GO:0005172 vascular endothelial growth factor receptor binding 7/5838 13/18639 0.538461538461538 1.7191477587161 0.0769645851769447 0.239371547280422 GO:0043560 insulin receptor substrate binding 7/5838 13/18639 0.538461538461538 1.7191477587161 0.0769645851769447 0.239371547280422 GO:0097157 pre-mRNA intronic binding 7/5838 13/18639 0.538461538461538 1.7191477587161 0.0769645851769447 0.239371547280422 GO:0097110 scaffold protein binding 28/5838 70/18639 0.4 1.27708119218911 0.0770350754657052 0.239371547280422 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 46/5838 122/18639 0.377049180327869 1.2038060418176 0.0783121492654526 0.242785501481278 GO:0043539 protein serine/threonine kinase activator activity 29/5838 73/18639 0.397260273972603 1.26833406073576 0.0790394312788103 0.244483331751047 GO:0008376 acetylgalactosaminyltransferase activity 15/5838 34/18639 0.441176470588235 1.40854543256151 0.079688546784095 0.245932227150007 GO:0005112 Notch binding 12/5838 26/18639 0.461538461538462 1.47355522175666 0.0806561481612417 0.247236526232995 GO:0005160 transforming growth factor beta receptor binding 12/5838 26/18639 0.461538461538462 1.47355522175666 0.0806561481612417 0.247236526232995 GO:0043548 phosphatidylinositol 3-kinase binding 12/5838 26/18639 0.461538461538462 1.47355522175666 0.0806561481612417 0.247236526232995 GO:0140034 methylation-dependent protein binding 30/5838 76/18639 0.394736842105263 1.26027749229188 0.0809177802952333 0.247481121307444 GO:0009378 four-way junction helicase activity 20/5838 48/18639 0.416666666666667 1.33029290853032 0.0842247813947535 0.257017774614932 GO:0072542 protein phosphatase activator activity 10/5838 21/18639 0.476190476190476 1.52033475260608 0.087344386896656 0.265941186949326 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 17/5838 40/18639 0.425 1.35689876670092 0.0898641602727866 0.273002504757283 GO:0015485 cholesterol binding 22/5838 54/18639 0.407407407407407 1.30073084389631 0.0908219865476779 0.274076992663835 GO:0051287 NAD binding 22/5838 54/18639 0.407407407407407 1.30073084389631 0.0908219865476779 0.274076992663835 GO:0140463 chromatin-protein adaptor activity 22/5838 54/18639 0.407407407407407 1.30073084389631 0.0908219865476779 0.274076992663835 GO:0005159 insulin-like growth factor receptor binding 8/5838 16/18639 0.5 1.59635149023638 0.0927825143722339 0.276527055703254 GO:0008142 oxysterol binding 8/5838 16/18639 0.5 1.59635149023638 0.0927825143722339 0.276527055703254 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 8/5838 16/18639 0.5 1.59635149023638 0.0927825143722339 0.276527055703254 GO:0017070 U6 snRNA binding 8/5838 16/18639 0.5 1.59635149023638 0.0927825143722339 0.276527055703254 GO:0030275 LRR domain binding 8/5838 16/18639 0.5 1.59635149023638 0.0927825143722339 0.276527055703254 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 6/5838 11/18639 0.545454545454545 1.74147435298514 0.0940720255625324 0.276527055703254 GO:0019206 nucleoside kinase activity 6/5838 11/18639 0.545454545454545 1.74147435298514 0.0940720255625324 0.276527055703254 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 6/5838 11/18639 0.545454545454545 1.74147435298514 0.0940720255625324 0.276527055703254 GO:0034056 estrogen response element binding 6/5838 11/18639 0.545454545454545 1.74147435298514 0.0940720255625324 0.276527055703254 GO:0050998 nitric-oxide synthase binding 6/5838 11/18639 0.545454545454545 1.74147435298514 0.0940720255625324 0.276527055703254 GO:0097493 structural molecule activity conferring elasticity 6/5838 11/18639 0.545454545454545 1.74147435298514 0.0940720255625324 0.276527055703254 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 6/5838 11/18639 0.545454545454545 1.74147435298514 0.0940720255625324 0.276527055703254 GO:0070717 poly-purine tract binding 14/5838 32/18639 0.4375 1.39680755395683 0.0946104862778157 0.277510499620921 GO:0070300 phosphatidic acid binding 11/5838 24/18639 0.458333333333333 1.46332219938335 0.0969216113130372 0.283069341195373 GO:0070840 dynein complex binding 11/5838 24/18639 0.458333333333333 1.46332219938335 0.0969216113130372 0.283069341195373 GO:0016763 pentosyltransferase activity 20/5838 49/18639 0.408163265306122 1.30314407366235 0.101861299978286 0.296859163320015 GO:0001671 ATPase activator activity 12/5838 27/18639 0.444444444444444 1.41897910243234 0.105208123615366 0.305957812479729 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 9/5838 19/18639 0.473684210526316 1.51233299075026 0.10585075311765 0.306516755304514 GO:0005346 purine ribonucleotide transmembrane transporter activity 9/5838 19/18639 0.473684210526316 1.51233299075026 0.10585075311765 0.306516755304514 GO:0031490 chromatin DNA binding 47/5838 128/18639 0.3671875 1.17232062564234 0.111148634996178 0.321174718109974 GO:0015215 nucleotide transmembrane transporter activity 13/5838 30/18639 0.433333333333333 1.38350462487153 0.112412223583853 0.322770118771357 GO:0031624 ubiquitin conjugating enzyme binding 13/5838 30/18639 0.433333333333333 1.38350462487153 0.112412223583853 0.322770118771357 GO:0070566 adenylyltransferase activity 13/5838 30/18639 0.433333333333333 1.38350462487153 0.112412223583853 0.322770118771357 GO:0019905 syntaxin binding 24/5838 61/18639 0.39344262295082 1.2561454349401 0.113441093645236 0.323912994680039 GO:0005347 ATP transmembrane transporter activity 7/5838 14/18639 0.5 1.59635149023638 0.113524245747523 0.323912994680039 GO:1990825 sequence-specific mRNA binding 7/5838 14/18639 0.5 1.59635149023638 0.113524245747523 0.323912994680039 GO:0051213 dioxygenase activity 35/5838 93/18639 0.376344086021505 1.20155488512416 0.115329577871152 0.328375639085017 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 14/5838 33/18639 0.424242424242424 1.35448005232178 0.118704698394466 0.337279946795133 GO:0042277 peptide binding 87/5838 249/18639 0.349397590361446 1.11552272811699 0.121439017645825 0.344330214616601 GO:0016835 carbon-oxygen lyase activity 30/5838 79/18639 0.379746835443038 1.21241885334409 0.124643291724243 0.352680914837203 GO:0008139 nuclear localization sequence binding 11/5838 25/18639 0.44 1.40478931140802 0.125901681467167 0.354033447266145 GO:0008483 transaminase activity 11/5838 25/18639 0.44 1.40478931140802 0.125901681467167 0.354033447266145 GO:0017056 structural constituent of nuclear pore 11/5838 25/18639 0.44 1.40478931140802 0.125901681467167 0.354033447266145 GO:0004197 cysteine-type endopeptidase activity 33/5838 88/18639 0.375 1.19726361767729 0.128385378543375 0.355548802656668 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 8/5838 17/18639 0.470588235294118 1.50244846139895 0.12879174115337 0.355548802656668 GO:0004549 tRNA-specific ribonuclease activity 8/5838 17/18639 0.470588235294118 1.50244846139895 0.12879174115337 0.355548802656668 GO:0004550 nucleoside diphosphate kinase activity 8/5838 17/18639 0.470588235294118 1.50244846139895 0.12879174115337 0.355548802656668 GO:0005092 GDP-dissociation inhibitor activity 8/5838 17/18639 0.470588235294118 1.50244846139895 0.12879174115337 0.355548802656668 GO:0017110 nucleoside diphosphate phosphatase activity 8/5838 17/18639 0.470588235294118 1.50244846139895 0.12879174115337 0.355548802656668 GO:0032977 membrane insertase activity 8/5838 17/18639 0.470588235294118 1.50244846139895 0.12879174115337 0.355548802656668 GO:0038191 neuropilin binding 8/5838 17/18639 0.470588235294118 1.50244846139895 0.12879174115337 0.355548802656668 GO:0051787 misfolded protein binding 8/5838 17/18639 0.470588235294118 1.50244846139895 0.12879174115337 0.355548802656668 GO:0004879 nuclear receptor activity 23/5838 59/18639 0.389830508474576 1.24461302628599 0.129957808676252 0.358041655077691 GO:0008307 structural constituent of muscle 17/5838 42/18639 0.404761904761905 1.29228453971517 0.133381780549444 0.365312479635589 GO:0008013 beta-catenin binding 39/5838 106/18639 0.367924528301887 1.17467373809847 0.133406981126706 0.365312479635589 GO:0046875 ephrin receptor binding 12/5838 28/18639 0.428571428571429 1.36830127734547 0.133670547287673 0.365312479635589 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 12/5838 28/18639 0.428571428571429 1.36830127734547 0.133670547287673 0.365312479635589 GO:0003777 microtubule motor activity 26/5838 68/18639 0.382352941176471 1.22073937488665 0.136114234863295 0.37046368429205 GO:0002020 protease binding 49/5838 136/18639 0.360294117647059 1.15031210325857 0.137091686137594 0.37046368429205 GO:0019838 growth factor binding 49/5838 136/18639 0.360294117647059 1.15031210325857 0.137091686137594 0.37046368429205 GO:0051539 4 iron, 4 sulfur cluster binding 18/5838 45/18639 0.4 1.27708119218911 0.137188892534315 0.37046368429205 GO:0004857 enzyme inhibitor activity 141/5838 416/18639 0.338942307692308 1.08214211597755 0.137917913853021 0.37046368429205 GO:0035064 methylated histone binding 28/5838 74/18639 0.378378378378378 1.2080497763951 0.139316078684109 0.37046368429205 GO:0000340 RNA 7-methylguanosine cap binding 6/5838 12/18639 0.5 1.59635149023638 0.139836824077877 0.37046368429205 GO:0003995 acyl-CoA dehydrogenase activity 6/5838 12/18639 0.5 1.59635149023638 0.139836824077877 0.37046368429205 GO:0005165 neurotrophin receptor binding 6/5838 12/18639 0.5 1.59635149023638 0.139836824077877 0.37046368429205 GO:0016423 tRNA (guanine) methyltransferase activity 6/5838 12/18639 0.5 1.59635149023638 0.139836824077877 0.37046368429205 GO:0035251 UDP-glucosyltransferase activity 6/5838 12/18639 0.5 1.59635149023638 0.139836824077877 0.37046368429205 GO:0035497 cAMP response element binding 6/5838 12/18639 0.5 1.59635149023638 0.139836824077877 0.37046368429205 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 6/5838 12/18639 0.5 1.59635149023638 0.139836824077877 0.37046368429205 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 6/5838 12/18639 0.5 1.59635149023638 0.139836824077877 0.37046368429205 GO:0141221 histone deacetylase activity, hydrolytic mechanism 6/5838 12/18639 0.5 1.59635149023638 0.139836824077877 0.37046368429205 GO:0016411 acylglycerol O-acyltransferase activity 13/5838 31/18639 0.419354838709677 1.33887544342406 0.140308442781227 0.37046368429205 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 9/5838 20/18639 0.45 1.43671634121274 0.140999403720266 0.37046368429205 GO:0042288 MHC class I protein binding 9/5838 20/18639 0.45 1.43671634121274 0.140999403720266 0.37046368429205 GO:0043024 ribosomal small subunit binding 9/5838 20/18639 0.45 1.43671634121274 0.140999403720266 0.37046368429205 GO:0061608 nuclear import signal receptor activity 9/5838 20/18639 0.45 1.43671634121274 0.140999403720266 0.37046368429205 GO:0003727 single-stranded RNA binding 33/5838 89/18639 0.370786516853933 1.18381121747867 0.145009492466131 0.38026574035916 GO:0052866 phosphatidylinositol phosphate phosphatase activity 14/5838 34/18639 0.411764705882353 1.31464240372408 0.146016004521727 0.382092770421166 GO:0003925 G protein activity 21/5838 54/18639 0.388888888888889 1.2416067146283 0.146267695363282 0.382092770421166 GO:0098531 ligand-modulated transcription factor activity 23/5838 60/18639 0.383333333333333 1.22386947584789 0.150806829619906 0.390491546484889 GO:0000295 adenine nucleotide transmembrane transporter activity 10/5838 23/18639 0.434782608695652 1.38813173064033 0.150917379464402 0.390491546484889 GO:0003887 DNA-directed DNA polymerase activity 10/5838 23/18639 0.434782608695652 1.38813173064033 0.150917379464402 0.390491546484889 GO:0005158 insulin receptor binding 10/5838 23/18639 0.434782608695652 1.38813173064033 0.150917379464402 0.390491546484889 GO:0008171 O-methyltransferase activity 10/5838 23/18639 0.434782608695652 1.38813173064033 0.150917379464402 0.390491546484889 GO:0010181 FMN binding 7/5838 15/18639 0.466666666666667 1.48992805755396 0.157473374356648 0.404692050626196 GO:0005227 calcium-activated cation channel activity 11/5838 26/18639 0.423076923076923 1.35075895327694 0.159081739224846 0.404692050626196 GO:0008143 poly(A) binding 11/5838 26/18639 0.423076923076923 1.35075895327694 0.159081739224846 0.404692050626196 GO:0008157 protein phosphatase 1 binding 11/5838 26/18639 0.423076923076923 1.35075895327694 0.159081739224846 0.404692050626196 GO:0008198 ferrous iron binding 11/5838 26/18639 0.423076923076923 1.35075895327694 0.159081739224846 0.404692050626196 GO:0015216 purine nucleotide transmembrane transporter activity 11/5838 26/18639 0.423076923076923 1.35075895327694 0.159081739224846 0.404692050626196 GO:0030507 spectrin binding 11/5838 26/18639 0.423076923076923 1.35075895327694 0.159081739224846 0.404692050626196 GO:0034237 protein kinase A regulatory subunit binding 11/5838 26/18639 0.423076923076923 1.35075895327694 0.159081739224846 0.404692050626196 GO:0120014 phospholipid transfer activity 11/5838 26/18639 0.423076923076923 1.35075895327694 0.159081739224846 0.404692050626196 GO:0140313 molecular sequestering activity 21/5838 55/18639 0.381818181818182 1.2190320470896 0.169794807698199 0.421622491924768 GO:0003746 translation elongation factor activity 8/5838 18/18639 0.444444444444444 1.41897910243234 0.170842597628147 0.421622491924768 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 8/5838 18/18639 0.444444444444444 1.41897910243234 0.170842597628147 0.421622491924768 GO:0004706 JUN kinase kinase kinase activity 8/5838 18/18639 0.444444444444444 1.41897910243234 0.170842597628147 0.421622491924768 GO:0017128 phospholipid scramblase activity 8/5838 18/18639 0.444444444444444 1.41897910243234 0.170842597628147 0.421622491924768 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 8/5838 18/18639 0.444444444444444 1.41897910243234 0.170842597628147 0.421622491924768 GO:0070628 proteasome binding 8/5838 18/18639 0.444444444444444 1.41897910243234 0.170842597628147 0.421622491924768 GO:0071813 lipoprotein particle binding 13/5838 32/18639 0.40625 1.29703558581706 0.171575465651982 0.421622491924768 GO:0071814 protein-lipid complex binding 13/5838 32/18639 0.40625 1.29703558581706 0.171575465651982 0.421622491924768 GO:0140142 nucleocytoplasmic carrier activity 13/5838 32/18639 0.40625 1.29703558581706 0.171575465651982 0.421622491924768 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 23/5838 61/18639 0.377049180327869 1.2038060418176 0.173422932972996 0.421622491924768 GO:0004382 GDP phosphatase activity 5/5838 10/18639 0.5 1.59635149023638 0.17379149005863 0.421622491924768 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 5/5838 10/18639 0.5 1.59635149023638 0.17379149005863 0.421622491924768 GO:0008190 eukaryotic initiation factor 4E binding 5/5838 10/18639 0.5 1.59635149023638 0.17379149005863 0.421622491924768 GO:0015643 toxic substance binding 5/5838 10/18639 0.5 1.59635149023638 0.17379149005863 0.421622491924768 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 5/5838 10/18639 0.5 1.59635149023638 0.17379149005863 0.421622491924768 GO:0031434 mitogen-activated protein kinase kinase binding 5/5838 10/18639 0.5 1.59635149023638 0.17379149005863 0.421622491924768 GO:0031996 thioesterase binding 5/5838 10/18639 0.5 1.59635149023638 0.17379149005863 0.421622491924768 GO:0032356 oxidized DNA binding 5/5838 10/18639 0.5 1.59635149023638 0.17379149005863 0.421622491924768 GO:0033204 ribonuclease P RNA binding 5/5838 10/18639 0.5 1.59635149023638 0.17379149005863 0.421622491924768 GO:0043295 glutathione binding 5/5838 10/18639 0.5 1.59635149023638 0.17379149005863 0.421622491924768 GO:0045322 unmethylated CpG binding 5/5838 10/18639 0.5 1.59635149023638 0.17379149005863 0.421622491924768 GO:0047429 nucleoside triphosphate diphosphatase activity 5/5838 10/18639 0.5 1.59635149023638 0.17379149005863 0.421622491924768 GO:0051864 histone H3K36 demethylase activity 5/5838 10/18639 0.5 1.59635149023638 0.17379149005863 0.421622491924768 GO:0051880 G-quadruplex DNA binding 5/5838 10/18639 0.5 1.59635149023638 0.17379149005863 0.421622491924768 GO:0070097 delta-catenin binding 5/5838 10/18639 0.5 1.59635149023638 0.17379149005863 0.421622491924768 GO:0005154 epidermal growth factor receptor binding 14/5838 35/18639 0.4 1.27708119218911 0.176392470967831 0.427171090724588 GO:0016757 glycosyltransferase activity 91/5838 267/18639 0.340823970037453 1.08814970495514 0.180183618916038 0.435577096527048 GO:0008373 sialyltransferase activity 9/5838 21/18639 0.428571428571429 1.36830127734547 0.181240666337973 0.437355579585073 GO:0004519 endonuclease activity 45/5838 127/18639 0.354330708661417 1.13127270961633 0.181772200624456 0.437861885044044 GO:0004540 RNA nuclease activity 43/5838 121/18639 0.355371900826446 1.13459692694487 0.18219397655042 0.438102477182193 GO:0016829 lyase activity 69/5838 200/18639 0.345 1.1014825282631 0.184156281297301 0.442040033237437 GO:0030215 semaphorin receptor binding 10/5838 24/18639 0.416666666666667 1.33029290853032 0.189485785286806 0.451646503984839 GO:0035035 histone acetyltransferase binding 10/5838 24/18639 0.416666666666667 1.33029290853032 0.189485785286806 0.451646503984839 GO:0050431 transforming growth factor beta binding 10/5838 24/18639 0.416666666666667 1.33029290853032 0.189485785286806 0.451646503984839 GO:0050699 WW domain binding 10/5838 24/18639 0.416666666666667 1.33029290853032 0.189485785286806 0.451646503984839 GO:0005035 death receptor activity 6/5838 13/18639 0.461538461538462 1.47355522175666 0.193727314564391 0.456164143809924 GO:0008253 5'-nucleotidase activity 6/5838 13/18639 0.461538461538462 1.47355522175666 0.193727314564391 0.456164143809924 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 6/5838 13/18639 0.461538461538462 1.47355522175666 0.193727314564391 0.456164143809924 GO:0019104 DNA N-glycosylase activity 6/5838 13/18639 0.461538461538462 1.47355522175666 0.193727314564391 0.456164143809924 GO:0019855 calcium channel inhibitor activity 6/5838 13/18639 0.461538461538462 1.47355522175666 0.193727314564391 0.456164143809924 GO:0046974 histone H3K9 methyltransferase activity 6/5838 13/18639 0.461538461538462 1.47355522175666 0.193727314564391 0.456164143809924 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 6/5838 13/18639 0.461538461538462 1.47355522175666 0.193727314564391 0.456164143809924 GO:0035255 ionotropic glutamate receptor binding 11/5838 27/18639 0.407407407407407 1.30073084389631 0.196119849956363 0.461000199983782 GO:0019843 rRNA binding 24/5838 65/18639 0.369230769230769 1.17884417740533 0.198703942044675 0.466269077797935 GO:0140223 general transcription initiation factor activity 25/5838 68/18639 0.367647058823529 1.17378786046793 0.199521947292376 0.467382737116908 GO:0048306 calcium-dependent protein binding 29/5838 80/18639 0.3625 1.15735483042138 0.201509343698239 0.468826968042687 GO:0001965 G-protein alpha-subunit binding 12/5838 30/18639 0.4 1.27708119218911 0.201516367601008 0.468826968042687 GO:0022839 monoatomic ion-gated channel activity 12/5838 30/18639 0.4 1.27708119218911 0.201516367601008 0.468826968042687 GO:0035925 mRNA 3'-UTR AU-rich region binding 12/5838 30/18639 0.4 1.27708119218911 0.201516367601008 0.468826968042687 GO:0052689 carboxylic ester hydrolase activity 33/5838 92/18639 0.358695652173913 1.14520867777827 0.20200360669695 0.469158547294453 GO:0016853 isomerase activity 62/5838 180/18639 0.344444444444444 1.09970880438506 0.203234849303096 0.471214020275151 GO:0019956 chemokine binding 13/5838 33/18639 0.393939393939394 1.25773147715594 0.205941464369368 0.475868137532615 GO:0140311 protein sequestering activity 13/5838 33/18639 0.393939393939394 1.25773147715594 0.205941464369368 0.475868137532615 GO:0003688 DNA replication origin binding 7/5838 16/18639 0.4375 1.39680755395683 0.207788487677859 0.477702925218861 GO:0004708 MAP kinase kinase activity 7/5838 16/18639 0.4375 1.39680755395683 0.207788487677859 0.477702925218861 GO:0055102 lipase inhibitor activity 7/5838 16/18639 0.4375 1.39680755395683 0.207788487677859 0.477702925218861 GO:0016409 palmitoyltransferase activity 14/5838 36/18639 0.388888888888889 1.2416067146283 0.209590105497412 0.481032265736893 GO:0019894 kinesin binding 16/5838 42/18639 0.380952380952381 1.21626780208486 0.21510867606002 0.492866848682975 GO:0031420 alkali metal ion binding 8/5838 19/18639 0.421052631578947 1.34429599177801 0.218109393635782 0.496665699879939 GO:0042577 lipid phosphatase activity 8/5838 19/18639 0.421052631578947 1.34429599177801 0.218109393635782 0.496665699879939 GO:0097001 ceramide binding 8/5838 19/18639 0.421052631578947 1.34429599177801 0.218109393635782 0.496665699879939 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 62/5838 181/18639 0.342541436464088 1.09363306513432 0.218226369234536 0.496665699879939 GO:1902936 phosphatidylinositol bisphosphate binding 39/5838 111/18639 0.351351351351351 1.12176050665259 0.22024731682219 0.500428377621036 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 22/5838 60/18639 0.366666666666667 1.17065775950668 0.223053147397941 0.505958889347663 GO:0008093 cytoskeletal anchor activity 9/5838 22/18639 0.409090909090909 1.30610576473886 0.225893713678326 0.511549657764063 GO:0019706 protein-cysteine S-palmitoyltransferase activity 10/5838 25/18639 0.4 1.27708119218911 0.231875187833232 0.521623356431453 GO:0019707 protein-cysteine S-acyltransferase activity 10/5838 25/18639 0.4 1.27708119218911 0.231875187833232 0.521623356431453 GO:0042974 nuclear retinoic acid receptor binding 10/5838 25/18639 0.4 1.27708119218911 0.231875187833232 0.521623356431453 GO:0120020 cholesterol transfer activity 10/5838 25/18639 0.4 1.27708119218911 0.231875187833232 0.521623356431453 GO:0019789 SUMO transferase activity 11/5838 28/18639 0.392857142857143 1.25427617090001 0.236528222271397 0.531212723616124 GO:0005114 type II transforming growth factor beta receptor binding 5/5838 11/18639 0.454545454545455 1.45122862748762 0.24022437713871 0.531618499651682 GO:0005536 D-glucose binding 5/5838 11/18639 0.454545454545455 1.45122862748762 0.24022437713871 0.531618499651682 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 5/5838 11/18639 0.454545454545455 1.45122862748762 0.24022437713871 0.531618499651682 GO:0019107 myristoyltransferase activity 5/5838 11/18639 0.454545454545455 1.45122862748762 0.24022437713871 0.531618499651682 GO:0032404 mismatch repair complex binding 5/5838 11/18639 0.454545454545455 1.45122862748762 0.24022437713871 0.531618499651682 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 5/5838 11/18639 0.454545454545455 1.45122862748762 0.24022437713871 0.531618499651682 GO:0045294 alpha-catenin binding 5/5838 11/18639 0.454545454545455 1.45122862748762 0.24022437713871 0.531618499651682 GO:0047676 arachidonate-CoA ligase activity 5/5838 11/18639 0.454545454545455 1.45122862748762 0.24022437713871 0.531618499651682 GO:1900750 oligopeptide binding 5/5838 11/18639 0.454545454545455 1.45122862748762 0.24022437713871 0.531618499651682 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 13/5838 34/18639 0.382352941176471 1.22073937488665 0.243038177608384 0.536972337215927 GO:0015036 disulfide oxidoreductase activity 15/5838 40/18639 0.375 1.19726361767729 0.247033266268645 0.544914546825974 GO:0098631 cell adhesion mediator activity 27/5838 76/18639 0.355263157894737 1.13424974306269 0.249442331349448 0.549338208683817 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 24/5838 67/18639 0.358208955223881 1.14365479897532 0.250676083047995 0.550207105621497 GO:0004536 DNA nuclease activity 23/5838 64/18639 0.359375 1.1473776336074 0.250916487351652 0.550207105621497 GO:0016836 hydro-lyase activity 22/5838 61/18639 0.360655737704918 1.1514666486951 0.251049678612013 0.550207105621497 GO:0008195 phosphatidate phosphatase activity 6/5838 14/18639 0.428571428571429 1.36830127734547 0.253879616177042 0.550207257351838 GO:0016530 metallochaperone activity 6/5838 14/18639 0.428571428571429 1.36830127734547 0.253879616177042 0.550207257351838 GO:0019992 diacylglycerol binding 6/5838 14/18639 0.428571428571429 1.36830127734547 0.253879616177042 0.550207257351838 GO:0032036 myosin heavy chain binding 6/5838 14/18639 0.428571428571429 1.36830127734547 0.253879616177042 0.550207257351838 GO:0042043 neurexin family protein binding 6/5838 14/18639 0.428571428571429 1.36830127734547 0.253879616177042 0.550207257351838 GO:0070742 C2H2 zinc finger domain binding 6/5838 14/18639 0.428571428571429 1.36830127734547 0.253879616177042 0.550207257351838 GO:0071933 Arp2/3 complex binding 6/5838 14/18639 0.428571428571429 1.36830127734547 0.253879616177042 0.550207257351838 GO:0004029 aldehyde dehydrogenase (NAD+) activity 7/5838 17/18639 0.411764705882353 1.31464240372408 0.263086210245001 0.56655115845482 GO:0008429 phosphatidylethanolamine binding 7/5838 17/18639 0.411764705882353 1.31464240372408 0.263086210245001 0.56655115845482 GO:0030169 low-density lipoprotein particle binding 7/5838 17/18639 0.411764705882353 1.31464240372408 0.263086210245001 0.56655115845482 GO:0070402 NADPH binding 7/5838 17/18639 0.411764705882353 1.31464240372408 0.263086210245001 0.56655115845482 GO:0000339 RNA cap binding 8/5838 20/18639 0.4 1.27708119218911 0.269516053579459 0.578566796406377 GO:0030742 GTP-dependent protein binding 8/5838 20/18639 0.4 1.27708119218911 0.269516053579459 0.578566796406377 GO:0030165 PDZ domain binding 29/5838 83/18639 0.349397590361446 1.11552272811699 0.273287629425594 0.585620535794257 GO:0017134 fibroblast growth factor binding 9/5838 23/18639 0.391304347826087 1.2493185575763 0.274092785672992 0.585620535794257 GO:0043274 phospholipase binding 9/5838 23/18639 0.391304347826087 1.2493185575763 0.274092785672992 0.585620535794257 GO:0004435 phosphatidylinositol phospholipase C activity 10/5838 26/18639 0.384615384615385 1.22796268479722 0.277371093213474 0.589846965411779 GO:0030247 polysaccharide binding 10/5838 26/18639 0.384615384615385 1.22796268479722 0.277371093213474 0.589846965411779 GO:0097602 cullin family protein binding 10/5838 26/18639 0.384615384615385 1.22796268479722 0.277371093213474 0.589846965411779 GO:0016417 S-acyltransferase activity 11/5838 29/18639 0.379310344827586 1.21102526845519 0.27970536866305 0.593883005850875 GO:0034061 DNA polymerase activity 13/5838 35/18639 0.371428571428571 1.18586110703274 0.282419731532348 0.597937274095335 GO:0016860 intramolecular oxidoreductase activity 19/5838 53/18639 0.358490566037736 1.14455389866005 0.282493510097943 0.597937274095335 GO:0000146 microfilament motor activity 14/5838 38/18639 0.368421052631579 1.17625899280576 0.283083936426659 0.59802393625211 GO:0017080 sodium channel regulator activity 15/5838 41/18639 0.365853658536585 1.16806206602662 0.283413254138582 0.59802393625211 GO:0044325 transmembrane transporter binding 46/5838 136/18639 0.338235294117647 1.07988483163049 0.292349705150906 0.615925617198735 GO:0030971 receptor tyrosine kinase binding 28/5838 81/18639 0.345679012345679 1.10365041300293 0.30086628555833 0.63288873979117 GO:0004000 adenosine deaminase activity 5/5838 12/18639 0.416666666666667 1.33029290853032 0.311929772182161 0.643391908413063 GO:0004300 enoyl-CoA hydratase activity 5/5838 12/18639 0.416666666666667 1.33029290853032 0.311929772182161 0.643391908413063 GO:0004526 ribonuclease P activity 5/5838 12/18639 0.416666666666667 1.33029290853032 0.311929772182161 0.643391908413063 GO:0008603 cAMP-dependent protein kinase regulator activity 5/5838 12/18639 0.416666666666667 1.33029290853032 0.311929772182161 0.643391908413063 GO:0015269 calcium-activated potassium channel activity 5/5838 12/18639 0.416666666666667 1.33029290853032 0.311929772182161 0.643391908413063 GO:0016208 AMP binding 5/5838 12/18639 0.416666666666667 1.33029290853032 0.311929772182161 0.643391908413063 GO:0016273 arginine N-methyltransferase activity 5/5838 12/18639 0.416666666666667 1.33029290853032 0.311929772182161 0.643391908413063 GO:0016274 protein-arginine N-methyltransferase activity 5/5838 12/18639 0.416666666666667 1.33029290853032 0.311929772182161 0.643391908413063 GO:0034452 dynactin binding 5/5838 12/18639 0.416666666666667 1.33029290853032 0.311929772182161 0.643391908413063 GO:0035197 siRNA binding 5/5838 12/18639 0.416666666666667 1.33029290853032 0.311929772182161 0.643391908413063 GO:0045295 gamma-catenin binding 5/5838 12/18639 0.416666666666667 1.33029290853032 0.311929772182161 0.643391908413063 GO:1990817 poly(A) RNA polymerase activity 5/5838 12/18639 0.416666666666667 1.33029290853032 0.311929772182161 0.643391908413063 GO:0015932 nucleobase-containing compound transmembrane transporter activity 20/5838 57/18639 0.350877192982456 1.12024665981501 0.314075101315831 0.643391908413063 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 19/5838 54/18639 0.351851851851852 1.12335845609227 0.315646276096346 0.643391908413063 GO:0050661 NADP binding 19/5838 54/18639 0.351851851851852 1.12335845609227 0.315646276096346 0.643391908413063 GO:0005010 insulin-like growth factor receptor activity 18/5838 51/18639 0.352941176470588 1.12683634604921 0.317175032906087 0.643391908413063 GO:0005041 low-density lipoprotein particle receptor activity 6/5838 15/18639 0.4 1.27708119218911 0.318150444057305 0.643391908413063 GO:0008252 nucleotidase activity 6/5838 15/18639 0.4 1.27708119218911 0.318150444057305 0.643391908413063 GO:0015556 C4-dicarboxylate transmembrane transporter activity 6/5838 15/18639 0.4 1.27708119218911 0.318150444057305 0.643391908413063 GO:0016846 carbon-sulfur lyase activity 6/5838 15/18639 0.4 1.27708119218911 0.318150444057305 0.643391908413063 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 6/5838 15/18639 0.4 1.27708119218911 0.318150444057305 0.643391908413063 GO:0031386 protein tag activity 6/5838 15/18639 0.4 1.27708119218911 0.318150444057305 0.643391908413063 GO:0033130 acetylcholine receptor binding 6/5838 15/18639 0.4 1.27708119218911 0.318150444057305 0.643391908413063 GO:0045504 dynein heavy chain binding 6/5838 15/18639 0.4 1.27708119218911 0.318150444057305 0.643391908413063 GO:0050700 CARD domain binding 6/5838 15/18639 0.4 1.27708119218911 0.318150444057305 0.643391908413063 GO:0141047 molecular tag activity 6/5838 15/18639 0.4 1.27708119218911 0.318150444057305 0.643391908413063 GO:0004520 DNA endonuclease activity 15/5838 42/18639 0.357142857142857 1.14025106445456 0.321360241960006 0.644178817057063 GO:0098641 cadherin binding involved in cell-cell adhesion 7/5838 18/18639 0.388888888888889 1.2416067146283 0.321786691001181 0.644178817057063 GO:1990381 ubiquitin-specific protease binding 7/5838 18/18639 0.388888888888889 1.2416067146283 0.321786691001181 0.644178817057063 GO:0045505 dynein intermediate chain binding 13/5838 36/18639 0.361111111111111 1.15292052072628 0.323584302769485 0.644178817057063 GO:0055106 ubiquitin-protein transferase regulator activity 13/5838 36/18639 0.361111111111111 1.15292052072628 0.323584302769485 0.644178817057063 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 13/5838 36/18639 0.361111111111111 1.15292052072628 0.323584302769485 0.644178817057063 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 13/5838 36/18639 0.361111111111111 1.15292052072628 0.323584302769485 0.644178817057063 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 13/5838 36/18639 0.361111111111111 1.15292052072628 0.323584302769485 0.644178817057063 GO:0140312 cargo adaptor activity 8/5838 21/18639 0.380952380952381 1.21626780208486 0.323839368804988 0.644178817057063 GO:0008187 poly-pyrimidine tract binding 11/5838 30/18639 0.366666666666667 1.17065775950668 0.32497268506739 0.644178817057063 GO:0004364 glutathione transferase activity 10/5838 27/18639 0.37037037037037 1.18248258536028 0.325165942188245 0.644178817057063 GO:0005385 zinc ion transmembrane transporter activity 10/5838 27/18639 0.37037037037037 1.18248258536028 0.325165942188245 0.644178817057063 GO:0008266 poly(U) RNA binding 10/5838 27/18639 0.37037037037037 1.18248258536028 0.325165942188245 0.644178817057063 GO:0008320 protein transmembrane transporter activity 10/5838 27/18639 0.37037037037037 1.18248258536028 0.325165942188245 0.644178817057063 GO:0051536 iron-sulfur cluster binding 26/5838 76/18639 0.342105263157895 1.09224049331963 0.332684625178642 0.658115951843215 GO:0043178 alcohol binding 31/5838 92/18639 0.33695652173913 1.07580209124626 0.347834328701965 0.687086388045535 GO:0016874 ligase activity 55/5838 167/18639 0.329341317365269 1.05148900554492 0.35335104270103 0.696972129153771 GO:0008375 acetylglucosaminyltransferase activity 15/5838 43/18639 0.348837209302326 1.11373359783934 0.36045806599863 0.709786362917602 GO:0051540 metal cluster binding 26/5838 77/18639 0.337662337662338 1.07805555184795 0.361834942860999 0.709786362917602 GO:0046625 sphingolipid binding 10/5838 28/18639 0.357142857142857 1.14025106445456 0.374409119919828 0.709786362917602 GO:0097718 disordered domain specific binding 10/5838 28/18639 0.357142857142857 1.14025106445456 0.374409119919828 0.709786362917602 GO:1901681 sulfur compound binding 89/5838 275/18639 0.323636363636364 1.03327478277119 0.375621927205912 0.709786362917602 GO:0000030 mannosyltransferase activity 9/5838 25/18639 0.36 1.1493730729702 0.377159247319905 0.709786362917602 GO:0017025 TBP-class protein binding 9/5838 25/18639 0.36 1.1493730729702 0.377159247319905 0.709786362917602 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 8/5838 22/18639 0.363636363636364 1.1609829019901 0.379808314591652 0.709786362917602 GO:0034062 5'-3' RNA polymerase activity 8/5838 22/18639 0.363636363636364 1.1609829019901 0.379808314591652 0.709786362917602 GO:0097747 RNA polymerase activity 8/5838 22/18639 0.363636363636364 1.1609829019901 0.379808314591652 0.709786362917602 GO:0008574 plus-end-directed microtubule motor activity 7/5838 19/18639 0.368421052631579 1.17625899280576 0.38226511446433 0.709786362917602 GO:0120227 acyl-CoA binding 7/5838 19/18639 0.368421052631579 1.17625899280576 0.38226511446433 0.709786362917602 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 6/5838 16/18639 0.375 1.19726361767729 0.384367617884973 0.709786362917602 GO:0005521 lamin binding 6/5838 16/18639 0.375 1.19726361767729 0.384367617884973 0.709786362917602 GO:0008296 3'-5'-DNA exonuclease activity 6/5838 16/18639 0.375 1.19726361767729 0.384367617884973 0.709786362917602 GO:0015562 efflux transmembrane transporter activity 6/5838 16/18639 0.375 1.19726361767729 0.384367617884973 0.709786362917602 GO:0022858 alanine transmembrane transporter activity 6/5838 16/18639 0.375 1.19726361767729 0.384367617884973 0.709786362917602 GO:0043023 ribosomal large subunit binding 6/5838 16/18639 0.375 1.19726361767729 0.384367617884973 0.709786362917602 GO:0002161 aminoacyl-tRNA editing activity 5/5838 13/18639 0.384615384615385 1.22796268479722 0.385806308193268 0.709786362917602 GO:0004535 poly(A)-specific ribonuclease activity 5/5838 13/18639 0.384615384615385 1.22796268479722 0.385806308193268 0.709786362917602 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 5/5838 13/18639 0.384615384615385 1.22796268479722 0.385806308193268 0.709786362917602 GO:0005338 nucleotide-sugar transmembrane transporter activity 5/5838 13/18639 0.384615384615385 1.22796268479722 0.385806308193268 0.709786362917602 GO:0017154 semaphorin receptor activity 5/5838 13/18639 0.384615384615385 1.22796268479722 0.385806308193268 0.709786362917602 GO:0030955 potassium ion binding 5/5838 13/18639 0.384615384615385 1.22796268479722 0.385806308193268 0.709786362917602 GO:0031432 titin binding 5/5838 13/18639 0.384615384615385 1.22796268479722 0.385806308193268 0.709786362917602 GO:0035673 oligopeptide transmembrane transporter activity 5/5838 13/18639 0.384615384615385 1.22796268479722 0.385806308193268 0.709786362917602 GO:0039706 co-receptor binding 5/5838 13/18639 0.384615384615385 1.22796268479722 0.385806308193268 0.709786362917602 GO:0045159 myosin II binding 5/5838 13/18639 0.384615384615385 1.22796268479722 0.385806308193268 0.709786362917602 GO:0051011 microtubule minus-end binding 5/5838 13/18639 0.384615384615385 1.22796268479722 0.385806308193268 0.709786362917602 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 5/5838 13/18639 0.384615384615385 1.22796268479722 0.385806308193268 0.709786362917602 GO:0140666 annealing activity 5/5838 13/18639 0.384615384615385 1.22796268479722 0.385806308193268 0.709786362917602 GO:0004090 carbonyl reductase (NADPH) activity 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0004862 cAMP-dependent protein kinase inhibitor activity 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0005031 tumor necrosis factor receptor activity 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0005131 growth hormone receptor binding 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0008140 cAMP response element binding protein binding 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0008641 ubiquitin-like modifier activating enzyme activity 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0015658 branched-chain amino acid transmembrane transporter activity 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0016303 1-phosphatidylinositol-3-kinase activity 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0016783 sulfurtransferase activity 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0016868 intramolecular phosphotransferase activity 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0031419 cobalamin binding 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0031957 very long-chain fatty acid-CoA ligase activity 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0035256 G protein-coupled glutamate receptor binding 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0042975 peroxisome proliferator activated receptor binding 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0043422 protein kinase B binding 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0070513 death domain binding 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0140135 mechanosensitive monoatomic cation channel activity 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:1905394 retromer complex binding 4/5838 10/18639 0.4 1.27708119218911 0.385923518412216 0.709786362917602 GO:0038064 collagen receptor activity 18/5838 53/18639 0.339622641509434 1.0843142197832 0.388365899934079 0.712353085997684 GO:1901505 carbohydrate derivative transmembrane transporter activity 18/5838 53/18639 0.339622641509434 1.0843142197832 0.388365899934079 0.712353085997684 GO:0019842 vitamin binding 49/5838 150/18639 0.326666666666667 1.04294964028777 0.39042288152443 0.715162236547441 GO:0005006 epidermal growth factor receptor activity 17/5838 50/18639 0.34 1.08551901336074 0.392183156051261 0.71742106906689 GO:0140359 ABC-type transporter activity 16/5838 47/18639 0.340425531914894 1.08687761037371 0.396148273276162 0.723496945814245 GO:0019955 cytokine binding 47/5838 144/18639 0.326388888888889 1.04206277834875 0.396567760159755 0.723496945814245 GO:0016248 channel inhibitor activity 15/5838 44/18639 0.340909090909091 1.08842147061572 0.400277622627698 0.729287609633597 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 14/5838 41/18639 0.341463414634146 1.09019126162485 0.404590808998273 0.734197454728866 GO:0016877 ligase activity, forming carbon-sulfur bonds 14/5838 41/18639 0.341463414634146 1.09019126162485 0.404590808998273 0.734197454728866 GO:0042287 MHC protein binding 14/5838 41/18639 0.341463414634146 1.09019126162485 0.404590808998273 0.734197454728866 GO:0043015 gamma-tubulin binding 12/5838 35/18639 0.342857142857143 1.09464102187638 0.413869385376444 0.750034931421226 GO:0004714 transmembrane receptor protein tyrosine kinase activity 20/5838 60/18639 0.333333333333333 1.06423432682425 0.415446676598881 0.751892189961538 GO:0008194 UDP-glycosyltransferase activity 47/5838 145/18639 0.324137931034483 1.03487613849807 0.418648062560313 0.755131239775877 GO:0008378 galactosyltransferase activity 11/5838 32/18639 0.34375 1.09749164953751 0.418900871440696 0.755131239775877 GO:0022884 macromolecule transmembrane transporter activity 11/5838 32/18639 0.34375 1.09749164953751 0.418900871440696 0.755131239775877 GO:0004629 phospholipase C activity 10/5838 29/18639 0.344827586206897 1.10093206223199 0.42425319952866 0.759748163892771 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 10/5838 29/18639 0.344827586206897 1.10093206223199 0.42425319952866 0.759748163892771 GO:0035250 UDP-galactosyltransferase activity 10/5838 29/18639 0.344827586206897 1.10093206223199 0.42425319952866 0.759748163892771 GO:0097472 cyclin-dependent protein kinase activity 10/5838 29/18639 0.344827586206897 1.10093206223199 0.42425319952866 0.759748163892771 GO:0106222 lncRNA binding 10/5838 29/18639 0.344827586206897 1.10093206223199 0.42425319952866 0.759748163892771 GO:0005021 vascular endothelial growth factor receptor activity 17/5838 51/18639 0.333333333333333 1.06423432682425 0.429687217623849 0.7629909199241 GO:0005030 neurotrophin receptor activity 17/5838 51/18639 0.333333333333333 1.06423432682425 0.429687217623849 0.7629909199241 GO:0016830 carbon-carbon lyase activity 17/5838 51/18639 0.333333333333333 1.06423432682425 0.429687217623849 0.7629909199241 GO:0030544 Hsp70 protein binding 17/5838 51/18639 0.333333333333333 1.06423432682425 0.429687217623849 0.7629909199241 GO:0004529 DNA exonuclease activity 9/5838 26/18639 0.346153846153846 1.1051664163175 0.429988270082134 0.7629909199241 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 9/5838 26/18639 0.346153846153846 1.1051664163175 0.429988270082134 0.7629909199241 GO:0052742 phosphatidylinositol kinase activity 9/5838 26/18639 0.346153846153846 1.1051664163175 0.429988270082134 0.7629909199241 GO:0033218 amide binding 79/5838 247/18639 0.319838056680162 1.02114791683137 0.434462806908773 0.769696158538221 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 16/5838 48/18639 0.333333333333333 1.06423432682425 0.43489812337685 0.769696158538221 GO:0016849 phosphorus-oxygen lyase activity 8/5838 23/18639 0.347826086956522 1.11050538451227 0.436189930014937 0.770979863312116 GO:0141110 transporter inhibitor activity 15/5838 45/18639 0.333333333333333 1.06423432682425 0.440391123747576 0.777396004436383 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 28/5838 86/18639 0.325581395348837 1.03948469131671 0.442199224390435 0.778928341608782 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 7/5838 20/18639 0.35 1.11744604316547 0.442976147248492 0.778928341608782 GO:0016505 peptidase activator activity involved in apoptotic process 7/5838 20/18639 0.35 1.11744604316547 0.442976147248492 0.778928341608782 GO:0048487 beta-tubulin binding 14/5838 42/18639 0.333333333333333 1.06423432682425 0.446206092517406 0.783089699540687 GO:0004659 prenyltransferase activity 6/5838 17/18639 0.352941176470588 1.12683634604921 0.450521112961321 0.783089699540687 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 6/5838 17/18639 0.352941176470588 1.12683634604921 0.450521112961321 0.783089699540687 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 6/5838 17/18639 0.352941176470588 1.12683634604921 0.450521112961321 0.783089699540687 GO:0015278 intracellularly gated calcium channel activity 6/5838 17/18639 0.352941176470588 1.12683634604921 0.450521112961321 0.783089699540687 GO:0016018 cyclosporin A binding 6/5838 17/18639 0.352941176470588 1.12683634604921 0.450521112961321 0.783089699540687 GO:0019198 transmembrane receptor protein phosphatase activity 6/5838 17/18639 0.352941176470588 1.12683634604921 0.450521112961321 0.783089699540687 GO:0046965 nuclear retinoid X receptor binding 6/5838 17/18639 0.352941176470588 1.12683634604921 0.450521112961321 0.783089699540687 GO:1990226 histone methyltransferase binding 6/5838 17/18639 0.352941176470588 1.12683634604921 0.450521112961321 0.783089699540687 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 13/5838 39/18639 0.333333333333333 1.06423432682425 0.452392354443627 0.784338846366594 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 13/5838 39/18639 0.333333333333333 1.06423432682425 0.452392354443627 0.784338846366594 GO:0005545 1-phosphatidylinositol binding 5/5838 14/18639 0.357142857142857 1.14025106445456 0.459098914868949 0.787936473060076 GO:0008474 palmitoyl-(protein) hydrolase activity 5/5838 14/18639 0.357142857142857 1.14025106445456 0.459098914868949 0.787936473060076 GO:0008559 ABC-type xenobiotic transporter activity 5/5838 14/18639 0.357142857142857 1.14025106445456 0.459098914868949 0.787936473060076 GO:0015926 glucosidase activity 5/5838 14/18639 0.357142857142857 1.14025106445456 0.459098914868949 0.787936473060076 GO:0034236 protein kinase A catalytic subunit binding 5/5838 14/18639 0.357142857142857 1.14025106445456 0.459098914868949 0.787936473060076 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 5/5838 14/18639 0.357142857142857 1.14025106445456 0.459098914868949 0.787936473060076 GO:0044548 S100 protein binding 5/5838 14/18639 0.357142857142857 1.14025106445456 0.459098914868949 0.787936473060076 GO:0098599 palmitoyl hydrolase activity 5/5838 14/18639 0.357142857142857 1.14025106445456 0.459098914868949 0.787936473060076 GO:0004016 adenylate cyclase activity 4/5838 11/18639 0.363636363636364 1.1609829019901 0.469180170568505 0.789435733964992 GO:0005225 volume-sensitive anion channel activity 4/5838 11/18639 0.363636363636364 1.1609829019901 0.469180170568505 0.789435733964992 GO:0008172 S-methyltransferase activity 4/5838 11/18639 0.363636363636364 1.1609829019901 0.469180170568505 0.789435733964992 GO:0010854 adenylate cyclase regulator activity 4/5838 11/18639 0.363636363636364 1.1609829019901 0.469180170568505 0.789435733964992 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 4/5838 11/18639 0.363636363636364 1.1609829019901 0.469180170568505 0.789435733964992 GO:0015173 aromatic amino acid transmembrane transporter activity 4/5838 11/18639 0.363636363636364 1.1609829019901 0.469180170568505 0.789435733964992 GO:0015217 ADP transmembrane transporter activity 4/5838 11/18639 0.363636363636364 1.1609829019901 0.469180170568505 0.789435733964992 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 4/5838 11/18639 0.363636363636364 1.1609829019901 0.469180170568505 0.789435733964992 GO:0032794 GTPase activating protein binding 4/5838 11/18639 0.363636363636364 1.1609829019901 0.469180170568505 0.789435733964992 GO:0035252 UDP-xylosyltransferase activity 4/5838 11/18639 0.363636363636364 1.1609829019901 0.469180170568505 0.789435733964992 GO:0042285 xylosyltransferase activity 4/5838 11/18639 0.363636363636364 1.1609829019901 0.469180170568505 0.789435733964992 GO:0048185 activin binding 4/5838 11/18639 0.363636363636364 1.1609829019901 0.469180170568505 0.789435733964992 GO:0070697 activin receptor binding 4/5838 11/18639 0.363636363636364 1.1609829019901 0.469180170568505 0.789435733964992 GO:0005004 GPI-linked ephrin receptor activity 16/5838 49/18639 0.326530612244898 1.04251525892988 0.473610644953618 0.789435733964992 GO:0005008 hepatocyte growth factor receptor activity 16/5838 49/18639 0.326530612244898 1.04251525892988 0.473610644953618 0.789435733964992 GO:0005009 insulin receptor activity 16/5838 49/18639 0.326530612244898 1.04251525892988 0.473610644953618 0.789435733964992 GO:0005011 macrophage colony-stimulating factor receptor activity 16/5838 49/18639 0.326530612244898 1.04251525892988 0.473610644953618 0.789435733964992 GO:0005018 platelet-derived growth factor alpha-receptor activity 16/5838 49/18639 0.326530612244898 1.04251525892988 0.473610644953618 0.789435733964992 GO:0005020 stem cell factor receptor activity 16/5838 49/18639 0.326530612244898 1.04251525892988 0.473610644953618 0.789435733964992 GO:0008288 boss receptor activity 16/5838 49/18639 0.326530612244898 1.04251525892988 0.473610644953618 0.789435733964992 GO:0036332 placental growth factor receptor activity 16/5838 49/18639 0.326530612244898 1.04251525892988 0.473610644953618 0.789435733964992 GO:0038062 protein tyrosine kinase collagen receptor activity 16/5838 49/18639 0.326530612244898 1.04251525892988 0.473610644953618 0.789435733964992 GO:0060175 brain-derived neurotrophic factor receptor activity 16/5838 49/18639 0.326530612244898 1.04251525892988 0.473610644953618 0.789435733964992 GO:0008106 alcohol dehydrogenase (NADP+) activity 10/5838 30/18639 0.333333333333333 1.06423432682425 0.473893456759294 0.789435733964992 GO:0005044 scavenger receptor activity 9/5838 27/18639 0.333333333333333 1.06423432682425 0.482399434029079 0.801643015523293 GO:0016405 CoA-ligase activity 9/5838 27/18639 0.333333333333333 1.06423432682425 0.482399434029079 0.801643015523293 GO:0008200 ion channel inhibitor activity 14/5838 43/18639 0.325581395348837 1.03948469131671 0.48760169152647 0.809299880692105 GO:0070888 E-box binding 19/5838 59/18639 0.322033898305085 1.02815858693191 0.490721010268171 0.813485133952474 GO:0004622 lysophospholipase activity 8/5838 24/18639 0.333333333333333 1.06423432682425 0.491856402070054 0.814375381042997 GO:0030331 nuclear estrogen receptor binding 13/5838 40/18639 0.325 1.03762846865365 0.49533051045703 0.818136923218468 GO:0050997 quaternary ammonium group binding 13/5838 40/18639 0.325 1.03762846865365 0.49533051045703 0.818136923218468 GO:0009975 cyclase activity 7/5838 21/18639 0.333333333333333 1.06423432682425 0.502544536470244 0.826042408376815 GO:0010314 phosphatidylinositol-5-phosphate binding 7/5838 21/18639 0.333333333333333 1.06423432682425 0.502544536470244 0.826042408376815 GO:0036122 BMP binding 7/5838 21/18639 0.333333333333333 1.06423432682425 0.502544536470244 0.826042408376815 GO:0051428 peptide hormone receptor binding 7/5838 21/18639 0.333333333333333 1.06423432682425 0.502544536470244 0.826042408376815 GO:0016251 RNA polymerase II general transcription initiation factor activity 17/5838 53/18639 0.320754716981132 1.02407454090636 0.504459949809367 0.82819058105012 GO:0016758 hexosyltransferase activity 62/5838 197/18639 0.314720812182741 1.00481007507265 0.508751018725745 0.829305335957672 GO:0008235 metalloexopeptidase activity 21/5838 66/18639 0.318181818181818 1.01586003924133 0.511632477571901 0.829305335957672 GO:0005007 fibroblast growth factor receptor activity 16/5838 50/18639 0.32 1.02166495375128 0.51192946326061 0.829305335957672 GO:0005017 platelet-derived growth factor receptor activity 16/5838 50/18639 0.32 1.02166495375128 0.51192946326061 0.829305335957672 GO:0005019 platelet-derived growth factor beta-receptor activity 16/5838 50/18639 0.32 1.02166495375128 0.51192946326061 0.829305335957672 GO:0015035 protein-disulfide reductase activity 11/5838 34/18639 0.323529411764706 1.03293331721178 0.512699776520324 0.829305335957672 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 11/5838 34/18639 0.323529411764706 1.03293331721178 0.512699776520324 0.829305335957672 GO:0051427 hormone receptor binding 11/5838 34/18639 0.323529411764706 1.03293331721178 0.512699776520324 0.829305335957672 GO:0008308 voltage-gated monoatomic anion channel activity 6/5838 18/18639 0.333333333333333 1.06423432682425 0.514888323941391 0.829305335957672 GO:0008409 5'-3' exonuclease activity 6/5838 18/18639 0.333333333333333 1.06423432682425 0.514888323941391 0.829305335957672 GO:0017075 syntaxin-1 binding 6/5838 18/18639 0.333333333333333 1.06423432682425 0.514888323941391 0.829305335957672 GO:0030228 lipoprotein particle receptor activity 6/5838 18/18639 0.333333333333333 1.06423432682425 0.514888323941391 0.829305335957672 GO:0031690 adrenergic receptor binding 6/5838 18/18639 0.333333333333333 1.06423432682425 0.514888323941391 0.829305335957672 GO:0035615 clathrin adaptor activity 6/5838 18/18639 0.333333333333333 1.06423432682425 0.514888323941391 0.829305335957672 GO:0099602 neurotransmitter receptor regulator activity 6/5838 18/18639 0.333333333333333 1.06423432682425 0.514888323941391 0.829305335957672 GO:1901611 phosphatidylglycerol binding 6/5838 18/18639 0.333333333333333 1.06423432682425 0.514888323941391 0.829305335957672 GO:1901682 sulfur compound transmembrane transporter activity 20/5838 63/18639 0.317460317460317 1.01355650173739 0.518448258253927 0.834052103408504 GO:0005496 steroid binding 34/5838 108/18639 0.314814814814815 1.00511019755624 0.522009043591191 0.837758711408331 GO:0005452 solute:inorganic anion antiporter activity 10/5838 31/18639 0.32258064516129 1.02990418724928 0.522598931657364 0.837758711408331 GO:0016878 acid-thiol ligase activity 10/5838 31/18639 0.32258064516129 1.02990418724928 0.522598931657364 0.837758711408331 GO:0004467 long-chain fatty acid-CoA ligase activity 5/5838 15/18639 0.333333333333333 1.06423432682425 0.529573150274772 0.845949598032822 GO:0005523 tropomyosin binding 5/5838 15/18639 0.333333333333333 1.06423432682425 0.529573150274772 0.845949598032822 GO:0047372 monoacylglycerol lipase activity 5/5838 15/18639 0.333333333333333 1.06423432682425 0.529573150274772 0.845949598032822 GO:0004521 RNA endonuclease activity 23/5838 73/18639 0.315068493150685 1.00592011713525 0.530477191876858 0.846400302631188 GO:0016866 intramolecular transferase activity 9/5838 28/18639 0.321428571428571 1.0262259580091 0.533552740712408 0.850310632446824 GO:0042169 SH2 domain binding 13/5838 41/18639 0.317073170731707 1.01232045722307 0.537459657562881 0.854535740587711 GO:0140318 protein transporter activity 13/5838 41/18639 0.317073170731707 1.01232045722307 0.537459657562881 0.854535740587711 GO:0001540 amyloid-beta binding 26/5838 83/18639 0.313253012048193 1.00012382520834 0.541082702369375 0.855003564501881 GO:0005537 D-mannose binding 8/5838 25/18639 0.32 1.02166495375128 0.545831533717182 0.855003564501881 GO:0015645 fatty acid ligase activity 8/5838 25/18639 0.32 1.02166495375128 0.545831533717182 0.855003564501881 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 8/5838 25/18639 0.32 1.02166495375128 0.545831533717182 0.855003564501881 GO:0047617 fatty acyl-CoA hydrolase activity 8/5838 25/18639 0.32 1.02166495375128 0.545831533717182 0.855003564501881 GO:0120515 fatty acid-CoA ligase activity 8/5838 25/18639 0.32 1.02166495375128 0.545831533717182 0.855003564501881 GO:0042887 amide transmembrane transporter activity 12/5838 38/18639 0.315789473684211 1.0082219938335 0.547296462244779 0.855003564501881 GO:0004859 phospholipase inhibitor activity 4/5838 12/18639 0.333333333333333 1.06423432682425 0.547805369761675 0.855003564501881 GO:0005049 nuclear export signal receptor activity 4/5838 12/18639 0.333333333333333 1.06423432682425 0.547805369761675 0.855003564501881 GO:0005247 voltage-gated chloride channel activity 4/5838 12/18639 0.333333333333333 1.06423432682425 0.547805369761675 0.855003564501881 GO:0016840 carbon-nitrogen lyase activity 4/5838 12/18639 0.333333333333333 1.06423432682425 0.547805369761675 0.855003564501881 GO:0042301 phosphate ion binding 4/5838 12/18639 0.333333333333333 1.06423432682425 0.547805369761675 0.855003564501881 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 4/5838 12/18639 0.333333333333333 1.06423432682425 0.547805369761675 0.855003564501881 GO:0070410 co-SMAD binding 4/5838 12/18639 0.333333333333333 1.06423432682425 0.547805369761675 0.855003564501881 GO:0097677 STAT family protein binding 4/5838 12/18639 0.333333333333333 1.06423432682425 0.547805369761675 0.855003564501881 GO:1990459 transferrin receptor binding 4/5838 12/18639 0.333333333333333 1.06423432682425 0.547805369761675 0.855003564501881 GO:0016229 steroid dehydrogenase activity 11/5838 35/18639 0.314285714285714 1.00342093672001 0.557997039127935 0.869912909797388 GO:0015245 fatty acid transmembrane transporter activity 6/5838 19/18639 0.315789473684211 1.0082219938335 0.576099036007727 0.896080900578876 GO:0016918 retinal binding 6/5838 19/18639 0.315789473684211 1.0082219938335 0.576099036007727 0.896080900578876 GO:0098632 cell-cell adhesion mediator activity 17/5838 55/18639 0.309090909090909 0.986835466691582 0.576848748091933 0.896222769581188 GO:0016859 cis-trans isomerase activity 13/5838 42/18639 0.30952380952381 0.988217589193951 0.578366428100507 0.896533836725274 GO:0042056 chemoattractant activity 13/5838 42/18639 0.30952380952381 0.988217589193951 0.578366428100507 0.896533836725274 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 9/5838 29/18639 0.310344827586207 0.990838856008789 0.582737534245095 0.902281893182679 GO:0019199 transmembrane receptor protein kinase activity 24/5838 78/18639 0.307692307692308 0.982370147837774 0.584329835699439 0.903267969088989 GO:0038024 cargo receptor activity 20/5838 65/18639 0.307692307692308 0.982370147837774 0.58470174927803 0.903267969088989 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 40/5838 130/18639 0.307692307692308 0.982370147837774 0.58700986136229 0.90580546634249 GO:0000062 fatty-acyl-CoA binding 5/5838 16/18639 0.3125 0.997719681397739 0.595575664997408 0.91487413099489 GO:0005324 long-chain fatty acid transmembrane transporter activity 5/5838 16/18639 0.3125 0.997719681397739 0.595575664997408 0.91487413099489 GO:0031435 mitogen-activated protein kinase kinase kinase binding 5/5838 16/18639 0.3125 0.997719681397739 0.595575664997408 0.91487413099489 GO:0097027 ubiquitin-protein transferase activator activity 5/5838 16/18639 0.3125 0.997719681397739 0.595575664997408 0.91487413099489 GO:0016289 acyl-CoA hydrolase activity 8/5838 26/18639 0.307692307692308 0.982370147837774 0.597317428666093 0.916515242857443 GO:0004033 aldo-keto reductase (NADPH) activity 11/5838 36/18639 0.305555555555556 0.975548132922234 0.60155048860506 0.921970962828251 GO:0004602 glutathione peroxidase activity 7/5838 23/18639 0.304347826086957 0.971692211448233 0.613910225637996 0.938669229816816 GO:0099186 structural constituent of postsynapse 7/5838 23/18639 0.304347826086957 0.971692211448233 0.613910225637996 0.938669229816816 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 13/5838 43/18639 0.302325581395349 0.965235784794092 0.617697813949257 0.938669229816816 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 4/5838 13/18639 0.307692307692308 0.982370147837774 0.619804952680968 0.938669229816816 GO:0008035 high-density lipoprotein particle binding 4/5838 13/18639 0.307692307692308 0.982370147837774 0.619804952680968 0.938669229816816 GO:0009982 pseudouridine synthase activity 4/5838 13/18639 0.307692307692308 0.982370147837774 0.619804952680968 0.938669229816816 GO:0061459 L-arginine transmembrane transporter activity 4/5838 13/18639 0.307692307692308 0.982370147837774 0.619804952680968 0.938669229816816 GO:0070123 transforming growth factor beta receptor activity, type III 4/5838 13/18639 0.307692307692308 0.982370147837774 0.619804952680968 0.938669229816816 GO:0071714 icosanoid transmembrane transporter activity 4/5838 13/18639 0.307692307692308 0.982370147837774 0.619804952680968 0.938669229816816 GO:0140410 monoatomic cation:bicarbonate symporter activity 4/5838 13/18639 0.307692307692308 0.982370147837774 0.619804952680968 0.938669229816816 GO:0005003 ephrin receptor activity 16/5838 53/18639 0.30188679245283 0.963834862029514 0.621411444573807 0.938669229816816 GO:0005005 transmembrane-ephrin receptor activity 16/5838 53/18639 0.30188679245283 0.963834862029514 0.621411444573807 0.938669229816816 GO:0005544 calcium-dependent phospholipid binding 16/5838 53/18639 0.30188679245283 0.963834862029514 0.621411444573807 0.938669229816816 GO:0016209 antioxidant activity 26/5838 86/18639 0.302325581395349 0.965235784794092 0.626097859001325 0.944699762861201 GO:0031210 phosphatidylcholine binding 9/5838 30/18639 0.3 0.957810894141829 0.629384996024724 0.947558605740763 GO:0098918 structural constituent of synapse 9/5838 30/18639 0.3 0.957810894141829 0.629384996024724 0.947558605740763 GO:0032813 tumor necrosis factor receptor superfamily binding 15/5838 50/18639 0.3 0.957810894141829 0.631950157876875 0.949030250290996 GO:0016004 phospholipase activator activity 6/5838 20/18639 0.3 0.957810894141829 0.633151702618828 0.949030250290996 GO:0016408 C-acyltransferase activity 6/5838 20/18639 0.3 0.957810894141829 0.633151702618828 0.949030250290996 GO:0140939 histone H4 methyltransferase activity 6/5838 20/18639 0.3 0.957810894141829 0.633151702618828 0.949030250290996 GO:0070851 growth factor receptor binding 42/5838 139/18639 0.302158273381295 0.964701619998965 0.642041981923639 0.961297180855966 GO:0043394 proteoglycan binding 11/5838 37/18639 0.297297297297297 0.949181967167579 0.642966057100445 0.961622861223853 GO:0070279 vitamin B6 binding 17/5838 57/18639 0.298245614035088 0.952209660842754 0.644771835172258 0.96210829627723 GO:0004683 calcium/calmodulin-dependent protein kinase activity 8/5838 27/18639 0.296296296296296 0.945986068288227 0.645703952723783 0.96210829627723 GO:0008519 ammonium channel activity 3/5838 10/18639 0.3 0.957810894141829 0.651731260146492 0.96210829627723 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 3/5838 10/18639 0.3 0.957810894141829 0.651731260146492 0.96210829627723 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 3/5838 10/18639 0.3 0.957810894141829 0.651731260146492 0.96210829627723 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 3/5838 10/18639 0.3 0.957810894141829 0.651731260146492 0.96210829627723 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 3/5838 10/18639 0.3 0.957810894141829 0.651731260146492 0.96210829627723 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 3/5838 10/18639 0.3 0.957810894141829 0.651731260146492 0.96210829627723 GO:0140940 histone H2A methyltransferase activity 3/5838 10/18639 0.3 0.957810894141829 0.651731260146492 0.96210829627723 GO:1990259 histone H2AQ104 methyltransferase activity 3/5838 10/18639 0.3 0.957810894141829 0.651731260146492 0.96210829627723 GO:1990763 arrestin family protein binding 3/5838 10/18639 0.3 0.957810894141829 0.651731260146492 0.96210829627723 GO:0016790 thiolester hydrolase activity 13/5838 44/18639 0.295454545454545 0.943298607866953 0.655165025997977 0.96210829627723 GO:0030547 signaling receptor inhibitor activity 13/5838 44/18639 0.295454545454545 0.943298607866953 0.655165025997977 0.96210829627723 GO:0008484 sulfuric ester hydrolase activity 5/5838 17/18639 0.294117647058824 0.939030288374343 0.656015061679111 0.96210829627723 GO:0008569 minus-end-directed microtubule motor activity 5/5838 17/18639 0.294117647058824 0.939030288374343 0.656015061679111 0.96210829627723 GO:0030548 acetylcholine receptor regulator activity 5/5838 17/18639 0.294117647058824 0.939030288374343 0.656015061679111 0.96210829627723 GO:0070492 oligosaccharide binding 5/5838 17/18639 0.294117647058824 0.939030288374343 0.656015061679111 0.96210829627723 GO:1901567 fatty acid derivative binding 5/5838 17/18639 0.294117647058824 0.939030288374343 0.656015061679111 0.96210829627723 GO:0016831 carboxy-lyase activity 10/5838 34/18639 0.294117647058824 0.939030288374343 0.657304370002584 0.962961515149102 GO:0042562 hormone binding 28/5838 94/18639 0.297872340425532 0.951017909076994 0.663262437361501 0.965739546739448 GO:0005315 phosphate transmembrane transporter activity 7/5838 24/18639 0.291666666666667 0.931205035971223 0.664167682401266 0.965739546739448 GO:0019957 C-C chemokine binding 7/5838 24/18639 0.291666666666667 0.931205035971223 0.664167682401266 0.965739546739448 GO:0048027 mRNA 5'-UTR binding 7/5838 24/18639 0.291666666666667 0.931205035971223 0.664167682401266 0.965739546739448 GO:0060229 lipase activator activity 7/5838 24/18639 0.291666666666667 0.931205035971223 0.664167682401266 0.965739546739448 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 7/5838 24/18639 0.291666666666667 0.931205035971223 0.664167682401266 0.965739546739448 GO:0140612 DNA damage sensor activity 7/5838 24/18639 0.291666666666667 0.931205035971223 0.664167682401266 0.965739546739448 GO:0015175 neutral L-amino acid transmembrane transporter activity 12/5838 41/18639 0.292682926829268 0.934449652821297 0.668043955272936 0.970339192237423 GO:0005164 tumor necrosis factor receptor binding 9/5838 31/18639 0.290322580645161 0.926913768524351 0.673070204175009 0.973484110395522 GO:0017147 Wnt-protein binding 9/5838 31/18639 0.290322580645161 0.926913768524351 0.673070204175009 0.973484110395522 GO:0047499 calcium-independent phospholipase A2 activity 9/5838 31/18639 0.290322580645161 0.926913768524351 0.673070204175009 0.973484110395522 GO:0072349 modified amino acid transmembrane transporter activity 9/5838 31/18639 0.290322580645161 0.926913768524351 0.673070204175009 0.973484110395522 GO:0004065 arylsulfatase activity 4/5838 14/18639 0.285714285714286 0.912200851563647 0.684087367805775 0.980885392760793 GO:0005313 L-glutamate transmembrane transporter activity 4/5838 14/18639 0.285714285714286 0.912200851563647 0.684087367805775 0.980885392760793 GO:0008494 translation activator activity 4/5838 14/18639 0.285714285714286 0.912200851563647 0.684087367805775 0.980885392760793 GO:0042813 Wnt receptor activity 4/5838 14/18639 0.285714285714286 0.912200851563647 0.684087367805775 0.980885392760793 GO:0061665 SUMO ligase activity 4/5838 14/18639 0.285714285714286 0.912200851563647 0.684087367805775 0.980885392760793 GO:1901612 cardiolipin binding 4/5838 14/18639 0.285714285714286 0.912200851563647 0.684087367805775 0.980885392760793 GO:0005123 death receptor binding 6/5838 21/18639 0.285714285714286 0.912200851563647 0.685394569078261 0.980885392760793 GO:0005248 voltage-gated sodium channel activity 6/5838 21/18639 0.285714285714286 0.912200851563647 0.685394569078261 0.980885392760793 GO:0015174 basic amino acid transmembrane transporter activity 6/5838 21/18639 0.285714285714286 0.912200851563647 0.685394569078261 0.980885392760793 GO:1904047 S-adenosyl-L-methionine binding 6/5838 21/18639 0.285714285714286 0.912200851563647 0.685394569078261 0.980885392760793 GO:0046915 transition metal ion transmembrane transporter activity 13/5838 45/18639 0.288888888888889 0.922336416581021 0.690544289754927 0.986210072902478 GO:0050698 proteoglycan sulfotransferase activity 8/5838 28/18639 0.285714285714286 0.912200851563647 0.690564437528333 0.986210072902478 GO:0015297 antiporter activity 40/5838 135/18639 0.296296296296296 0.945986068288227 0.694911969619966 0.99137860655427 GO:0008238 exopeptidase activity 30/5838 102/18639 0.294117647058824 0.939030288374343 0.69638548448462 0.992440465323108 GO:0005200 structural constituent of cytoskeleton 33/5838 112/18639 0.294642857142857 0.940707128175011 0.69768667780606 0.993254778759464 GO:0036002 pre-mRNA binding 17/5838 59/18639 0.288135593220339 0.919931367254864 0.706703849248766 1 GO:0008201 heparin binding 51/5838 172/18639 0.296511627906977 0.946673558163436 0.708799344395923 1 GO:0015172 acidic amino acid transmembrane transporter activity 5/5838 18/18639 0.277777777777778 0.886861939020212 0.710294576193618 1 GO:0034185 apolipoprotein binding 5/5838 18/18639 0.277777777777778 0.886861939020212 0.710294576193618 1 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 9/5838 32/18639 0.28125 0.897947713257965 0.713505948323217 1 GO:0042910 xenobiotic transmembrane transporter activity 9/5838 32/18639 0.28125 0.897947713257965 0.713505948323217 1 GO:0047498 calcium-dependent phospholipase A2 activity 9/5838 32/18639 0.28125 0.897947713257965 0.713505948323217 1 GO:0030170 pyridoxal phosphate binding 16/5838 56/18639 0.285714285714286 0.912200851563647 0.717748086409951 1 GO:0000099 sulfur amino acid transmembrane transporter activity 3/5838 11/18639 0.272727272727273 0.870737176492572 0.720187918738238 1 GO:0003953 NAD+ nucleosidase activity 3/5838 11/18639 0.272727272727273 0.870737176492572 0.720187918738238 1 GO:0016176 superoxide-generating NADPH oxidase activator activity 3/5838 11/18639 0.272727272727273 0.870737176492572 0.720187918738238 1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/5838 11/18639 0.272727272727273 0.870737176492572 0.720187918738238 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 3/5838 11/18639 0.272727272727273 0.870737176492572 0.720187918738238 1 GO:0019203 carbohydrate phosphatase activity 3/5838 11/18639 0.272727272727273 0.870737176492572 0.720187918738238 1 GO:0019215 intermediate filament binding 3/5838 11/18639 0.272727272727273 0.870737176492572 0.720187918738238 1 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 3/5838 11/18639 0.272727272727273 0.870737176492572 0.720187918738238 1 GO:0140031 phosphorylation-dependent protein binding 3/5838 11/18639 0.272727272727273 0.870737176492572 0.720187918738238 1 GO:0030276 clathrin binding 13/5838 46/18639 0.282608695652174 0.902285624916216 0.72367505179785 1 GO:0004222 metalloendopeptidase activity 32/5838 110/18639 0.290909090909091 0.928786321592077 0.725956749317999 1 GO:0004864 protein phosphatase inhibitor activity 15/5838 53/18639 0.283018867924528 0.903595183152669 0.729351383594085 1 GO:0005246 calcium channel regulator activity 15/5838 53/18639 0.283018867924528 0.903595183152669 0.729351383594085 1 GO:0016782 transferase activity, transferring sulphur-containing groups 20/5838 70/18639 0.285714285714286 0.912200851563647 0.730985770208328 1 GO:0003785 actin monomer binding 8/5838 29/18639 0.275862068965517 0.88074564978559 0.731641353064804 1 GO:0099604 ligand-gated calcium channel activity 8/5838 29/18639 0.275862068965517 0.88074564978559 0.731641353064804 1 GO:0004559 alpha-mannosidase activity 4/5838 15/18639 0.266666666666667 0.851387461459404 0.740274355998867 1 GO:0005402 carbohydrate:monoatomic cation symporter activity 4/5838 15/18639 0.266666666666667 0.851387461459404 0.740274355998867 1 GO:0015929 hexosaminidase activity 4/5838 15/18639 0.266666666666667 0.851387461459404 0.740274355998867 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 4/5838 15/18639 0.266666666666667 0.851387461459404 0.740274355998867 1 GO:0055105 ubiquitin-protein transferase inhibitor activity 4/5838 15/18639 0.266666666666667 0.851387461459404 0.740274355998867 1 GO:0008237 metallopeptidase activity 54/5838 184/18639 0.293478260869565 0.936988918182225 0.743526574687186 1 GO:0030246 carbohydrate binding 83/5838 280/18639 0.296428571428571 0.946408383497284 0.748803920636102 1 GO:0019239 deaminase activity 9/5838 33/18639 0.272727272727273 0.870737176492572 0.750530576239292 1 GO:0005201 extracellular matrix structural constituent 49/5838 168/18639 0.291666666666667 0.931205035971223 0.752658692490623 1 GO:0003756 protein disulfide isomerase activity 5/5838 19/18639 0.263157894736842 0.840184994861254 0.758221554831436 1 GO:0005229 intracellularly calcium-gated chloride channel activity 5/5838 19/18639 0.263157894736842 0.840184994861254 0.758221554831436 1 GO:0008381 mechanosensitive monoatomic ion channel activity 5/5838 19/18639 0.263157894736842 0.840184994861254 0.758221554831436 1 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 5/5838 19/18639 0.263157894736842 0.840184994861254 0.758221554831436 1 GO:0022821 solute:potassium antiporter activity 5/5838 19/18639 0.263157894736842 0.840184994861254 0.758221554831436 1 GO:0030506 ankyrin binding 5/5838 19/18639 0.263157894736842 0.840184994861254 0.758221554831436 1 GO:0043395 heparan sulfate proteoglycan binding 5/5838 19/18639 0.263157894736842 0.840184994861254 0.758221554831436 1 GO:0070003 threonine-type peptidase activity 5/5838 19/18639 0.263157894736842 0.840184994861254 0.758221554831436 1 GO:0141147 intracellularly calcium-gated channel activity 5/5838 19/18639 0.263157894736842 0.840184994861254 0.758221554831436 1 GO:0015026 coreceptor activity 17/5838 61/18639 0.278688524590164 0.889769683082574 0.761703623200981 1 GO:0033612 receptor serine/threonine kinase binding 8/5838 30/18639 0.266666666666667 0.851387461459404 0.76882548289756 1 GO:0048019 receptor antagonist activity 8/5838 30/18639 0.266666666666667 0.851387461459404 0.76882548289756 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 6/5838 23/18639 0.260869565217391 0.832879038384199 0.774334233714991 1 GO:0031681 G-protein beta-subunit binding 6/5838 23/18639 0.260869565217391 0.832879038384199 0.774334233714991 1 GO:0140103 catalytic activity, acting on a glycoprotein 6/5838 23/18639 0.260869565217391 0.832879038384199 0.774334233714991 1 GO:0003720 telomerase activity 3/5838 12/18639 0.25 0.798175745118191 0.777648768397092 1 GO:0004032 aldose reductase (NADPH) activity 3/5838 12/18639 0.25 0.798175745118191 0.777648768397092 1 GO:0005025 transforming growth factor beta receptor activity, type I 3/5838 12/18639 0.25 0.798175745118191 0.777648768397092 1 GO:0005026 transforming growth factor beta receptor activity, type II 3/5838 12/18639 0.25 0.798175745118191 0.777648768397092 1 GO:0008179 adenylate cyclase binding 3/5838 12/18639 0.25 0.798175745118191 0.777648768397092 1 GO:0015132 prostaglandin transmembrane transporter activity 3/5838 12/18639 0.25 0.798175745118191 0.777648768397092 1 GO:0015368 calcium:monoatomic cation antiporter activity 3/5838 12/18639 0.25 0.798175745118191 0.777648768397092 1 GO:0016361 activin receptor activity, type I 3/5838 12/18639 0.25 0.798175745118191 0.777648768397092 1 GO:0016362 activin receptor activity, type II 3/5838 12/18639 0.25 0.798175745118191 0.777648768397092 1 GO:0017002 activin receptor activity 3/5838 12/18639 0.25 0.798175745118191 0.777648768397092 1 GO:0035014 phosphatidylinositol 3-kinase regulator activity 3/5838 12/18639 0.25 0.798175745118191 0.777648768397092 1 GO:0036009 protein-glutamine N-methyltransferase activity 3/5838 12/18639 0.25 0.798175745118191 0.777648768397092 1 GO:0070679 inositol 1,4,5 trisphosphate binding 3/5838 12/18639 0.25 0.798175745118191 0.777648768397092 1 GO:0097371 MDM2/MDM4 family protein binding 3/5838 12/18639 0.25 0.798175745118191 0.777648768397092 1 GO:1990247 N6-methyladenosine-containing RNA reader activity 3/5838 12/18639 0.25 0.798175745118191 0.777648768397092 1 GO:0004812 aminoacyl-tRNA ligase activity 11/5838 41/18639 0.268292682926829 0.856578848419522 0.782533239663038 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 11/5838 41/18639 0.268292682926829 0.856578848419522 0.782533239663038 1 GO:0140828 metal cation:monoatomic cation antiporter activity 11/5838 41/18639 0.268292682926829 0.856578848419522 0.782533239663038 1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 9/5838 34/18639 0.264705882352941 0.845127259536908 0.784092010484507 1 GO:0015179 L-amino acid transmembrane transporter activity 17/5838 62/18639 0.274193548387097 0.875418559161887 0.786460327401691 1 GO:0005024 transforming growth factor beta receptor activity 4/5838 16/18639 0.25 0.798175745118191 0.788507252999354 1 GO:0015385 sodium:proton antiporter activity 4/5838 16/18639 0.25 0.798175745118191 0.788507252999354 1 GO:0015923 mannosidase activity 4/5838 16/18639 0.25 0.798175745118191 0.788507252999354 1 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 4/5838 16/18639 0.25 0.798175745118191 0.788507252999354 1 GO:0001786 phosphatidylserine binding 16/5838 59/18639 0.271186440677966 0.865817757416343 0.797348166261009 1 GO:0015459 potassium channel regulator activity 16/5838 59/18639 0.271186440677966 0.865817757416343 0.797348166261009 1 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 16/5838 59/18639 0.271186440677966 0.865817757416343 0.797348166261009 1 GO:0005501 retinoid binding 10/5838 38/18639 0.263157894736842 0.840184994861254 0.797883224450517 1 GO:0019840 isoprenoid binding 10/5838 38/18639 0.263157894736842 0.840184994861254 0.797883224450517 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 5/5838 20/18639 0.25 0.798175745118191 0.799911505568972 1 GO:0010851 cyclase regulator activity 5/5838 20/18639 0.25 0.798175745118191 0.799911505568972 1 GO:0140664 ATP-dependent DNA damage sensor activity 5/5838 20/18639 0.25 0.798175745118191 0.799911505568972 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 8/5838 31/18639 0.258064516129032 0.823923349799423 0.802131666801056 1 GO:0008327 methyl-CpG binding 8/5838 31/18639 0.258064516129032 0.823923349799423 0.802131666801056 1 GO:0019212 phosphatase inhibitor activity 15/5838 56/18639 0.267857142857143 0.855188298340919 0.808631935687209 1 GO:0005507 copper ion binding 17/5838 63/18639 0.26984126984127 0.861523026476778 0.809372465324256 1 GO:0031492 nucleosomal DNA binding 11/5838 42/18639 0.261904761904762 0.836184113933343 0.810430046396343 1 GO:0030552 cAMP binding 6/5838 24/18639 0.25 0.798175745118191 0.811056417486233 1 GO:0004623 phospholipase A2 activity 9/5838 35/18639 0.257142857142857 0.820980766407282 0.814229794068683 1 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 37/5838 132/18639 0.28030303030303 0.894924320284032 0.818692289722584 1 GO:0016500 protein-hormone receptor activity 18/5838 67/18639 0.26865671641791 0.857741099231489 0.82047907929009 1 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 34/5838 122/18639 0.278688524590164 0.889769683082574 0.821496253139753 1 GO:0015101 organic cation transmembrane transporter activity 22/5838 81/18639 0.271604938271605 0.867153895930874 0.823095565291525 1 GO:0003964 RNA-directed DNA polymerase activity 3/5838 13/18639 0.230769230769231 0.73677761087833 0.825001913111929 1 GO:0070700 BMP receptor binding 3/5838 13/18639 0.230769230769231 0.73677761087833 0.825001913111929 1 GO:0000217 DNA secondary structure binding 10/5838 39/18639 0.256410256410256 0.818641789864811 0.825336515310394 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 4/5838 17/18639 0.235294117647059 0.751224230699474 0.82927408109789 1 GO:0036041 long-chain fatty acid binding 4/5838 17/18639 0.235294117647059 0.751224230699474 0.82927408109789 1 GO:0140299 molecular sensor activity 19/5838 71/18639 0.267605633802817 0.854385304633557 0.830766964570418 1 GO:0004601 peroxidase activity 15/5838 57/18639 0.263157894736842 0.840184994861254 0.830919547190384 1 GO:0004620 phospholipase activity 30/5838 109/18639 0.275229357798165 0.878725590955807 0.831536934168625 1 GO:0043425 bHLH transcription factor binding 8/5838 32/18639 0.25 0.798175745118191 0.831673572960336 1 GO:0003707 nuclear steroid receptor activity 6/5838 25/18639 0.24 0.766248715313464 0.842909824341335 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 6/5838 25/18639 0.24 0.766248715313464 0.842909824341335 1 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 10/5838 40/18639 0.25 0.798175745118191 0.84984315295131 1 GO:0016597 amino acid binding 13/5838 51/18639 0.254901960784314 0.81382624992443 0.853811183136995 1 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 4/5838 18/18639 0.222222222222222 0.70948955121617 0.863268225356253 1 GO:0050811 GABA receptor binding 4/5838 18/18639 0.222222222222222 0.70948955121617 0.863268225356253 1 GO:0015386 potassium:proton antiporter activity 3/5838 14/18639 0.214285714285714 0.684150638672735 0.86343315274088 1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 3/5838 14/18639 0.214285714285714 0.684150638672735 0.86343315274088 1 GO:0031404 chloride ion binding 3/5838 14/18639 0.214285714285714 0.684150638672735 0.86343315274088 1 GO:0098821 BMP receptor activity 3/5838 14/18639 0.214285714285714 0.684150638672735 0.86343315274088 1 GO:0038187 pattern recognition receptor activity 12/5838 48/18639 0.25 0.798175745118191 0.865767959382183 1 GO:0008970 phospholipase A1 activity 5/5838 22/18639 0.227272727272727 0.72561431374381 0.866054976382556 1 GO:0015377 chloride:monoatomic cation symporter activity 5/5838 22/18639 0.227272727272727 0.72561431374381 0.866054976382556 1 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:0004955 prostaglandin receptor activity 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:0005381 iron ion transmembrane transporter activity 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:0008239 dipeptidyl-peptidase activity 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:0015187 glycine transmembrane transporter activity 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:0015279 store-operated calcium channel activity 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:0019531 oxalate transmembrane transporter activity 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:0035374 chondroitin sulfate binding 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:0043121 neurotrophin binding 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:0050308 sugar-phosphatase activity 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:0097177 mitochondrial ribosome binding 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:1990757 ubiquitin ligase activator activity 2/5838 10/18639 0.2 0.638540596094553 0.870250638643001 1 GO:0004112 cyclic-nucleotide phosphodiesterase activity 6/5838 26/18639 0.230769230769231 0.73677761087833 0.870251492334641 1 GO:0051139 metal cation:proton antiporter activity 6/5838 26/18639 0.230769230769231 0.73677761087833 0.870251492334641 1 GO:0099106 ion channel regulator activity 44/5838 160/18639 0.275 0.87799331963001 0.871959328277544 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 13/5838 52/18639 0.25 0.798175745118191 0.872982227286093 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 7/5838 30/18639 0.233333333333333 0.744964028776978 0.875118533190848 1 GO:0170055 lipid transmembrane transporter activity 14/5838 56/18639 0.25 0.798175745118191 0.879746407624624 1 GO:0090482 vitamin transmembrane transporter activity 8/5838 34/18639 0.235294117647059 0.751224230699474 0.880269276965398 1 GO:0005506 iron ion binding 42/5838 154/18639 0.272727272727273 0.870737176492572 0.880935098143504 1 GO:0016247 channel regulator activity 46/5838 168/18639 0.273809523809524 0.874192482748495 0.883874388843888 1 GO:0005109 frizzled binding 9/5838 38/18639 0.236842105263158 0.756166495375128 0.885489788747062 1 GO:0004497 monooxygenase activity 28/5838 106/18639 0.264150943396226 0.843355504275825 0.885667413650576 1 GO:0008146 sulfotransferase activity 13/5838 53/18639 0.245283018867925 0.78311582539898 0.890094140185434 1 GO:0017046 peptide hormone binding 13/5838 53/18639 0.245283018867925 0.78311582539898 0.890094140185434 1 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 4/5838 19/18639 0.210526315789474 0.672147995889003 0.891280670829537 1 GO:0008301 DNA binding, bending 4/5838 19/18639 0.210526315789474 0.672147995889003 0.891280670829537 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 4/5838 19/18639 0.210526315789474 0.672147995889003 0.891280670829537 1 GO:0005283 amino acid:sodium symporter activity 5/5838 23/18639 0.217391304347826 0.694065865320166 0.89153296045688 1 GO:0016493 C-C chemokine receptor activity 5/5838 23/18639 0.217391304347826 0.694065865320166 0.89153296045688 1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 5/5838 23/18639 0.217391304347826 0.694065865320166 0.89153296045688 1 GO:0008395 steroid hydroxylase activity 6/5838 27/18639 0.222222222222222 0.70948955121617 0.893496383448081 1 GO:0004089 carbonate dehydratase activity 3/5838 15/18639 0.2 0.638540596094553 0.894222851926384 1 GO:0004953 icosanoid receptor activity 3/5838 15/18639 0.2 0.638540596094553 0.894222851926384 1 GO:0017081 chloride channel regulator activity 3/5838 15/18639 0.2 0.638540596094553 0.894222851926384 1 GO:0030553 cGMP binding 3/5838 15/18639 0.2 0.638540596094553 0.894222851926384 1 GO:0034483 heparan sulfate sulfotransferase activity 3/5838 15/18639 0.2 0.638540596094553 0.894222851926384 1 GO:0048531 beta-1,3-galactosyltransferase activity 3/5838 15/18639 0.2 0.638540596094553 0.894222851926384 1 GO:0050780 dopamine receptor binding 3/5838 15/18639 0.2 0.638540596094553 0.894222851926384 1 GO:0005343 organic acid:sodium symporter activity 8/5838 35/18639 0.228571428571429 0.729760681250918 0.899836531157017 1 GO:0048020 CCR chemokine receptor binding 12/5838 50/18639 0.24 0.766248715313464 0.900584953783436 1 GO:0141108 transporter regulator activity 46/5838 170/18639 0.270588235294118 0.863907865304395 0.902236497142573 1 GO:0004954 prostanoid receptor activity 2/5838 11/18639 0.181818181818182 0.580491450995048 0.903597909732949 1 GO:0008046 axon guidance receptor activity 2/5838 11/18639 0.181818181818182 0.580491450995048 0.903597909732949 1 GO:0008199 ferric iron binding 2/5838 11/18639 0.181818181818182 0.580491450995048 0.903597909732949 1 GO:0008271 secondary active sulfate transmembrane transporter activity 2/5838 11/18639 0.181818181818182 0.580491450995048 0.903597909732949 1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/5838 11/18639 0.181818181818182 0.580491450995048 0.903597909732949 1 GO:0032050 clathrin heavy chain binding 2/5838 11/18639 0.181818181818182 0.580491450995048 0.903597909732949 1 GO:0048407 platelet-derived growth factor binding 2/5838 11/18639 0.181818181818182 0.580491450995048 0.903597909732949 1 GO:0050786 RAGE receptor binding 2/5838 11/18639 0.181818181818182 0.580491450995048 0.903597909732949 1 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/5838 11/18639 0.181818181818182 0.580491450995048 0.903597909732949 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 2/5838 11/18639 0.181818181818182 0.580491450995048 0.903597909732949 1 GO:0005539 glycosaminoglycan binding 67/5838 242/18639 0.276859504132231 0.883930164015187 0.903801590017956 1 GO:0061134 peptidase regulator activity 62/5838 226/18639 0.274336283185841 0.875874268979254 0.911135702693382 1 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 5/5838 24/18639 0.208333333333333 0.665146454265159 0.912710998080734 1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 5/5838 24/18639 0.208333333333333 0.665146454265159 0.912710998080734 1 GO:0015295 solute:proton symporter activity 5/5838 24/18639 0.208333333333333 0.665146454265159 0.912710998080734 1 GO:0051119 sugar transmembrane transporter activity 6/5838 28/18639 0.214285714285714 0.684150638672735 0.913085119277368 1 GO:0051537 2 iron, 2 sulfur cluster binding 6/5838 28/18639 0.214285714285714 0.684150638672735 0.913085119277368 1 GO:0001972 retinoic acid binding 4/5838 20/18639 0.2 0.638540596094553 0.914122962144679 1 GO:0016298 lipase activity 34/5838 130/18639 0.261538461538462 0.835014625662108 0.91643153682285 1 GO:0016798 hydrolase activity, acting on glycosyl bonds 34/5838 130/18639 0.261538461538462 0.835014625662108 0.91643153682285 1 GO:0019841 retinol binding 3/5838 16/18639 0.1875 0.598631808838643 0.918618759371083 1 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 3/5838 16/18639 0.1875 0.598631808838643 0.918618759371083 1 GO:0005126 cytokine receptor binding 76/5838 275/18639 0.276363636363636 0.882347005512473 0.919410238509103 1 GO:0016651 oxidoreductase activity, acting on NAD(P)H 22/5838 88/18639 0.25 0.798175745118191 0.921154610324696 1 GO:0008083 growth factor activity 43/5838 162/18639 0.265432098765432 0.847445852841536 0.921246183440652 1 GO:0004126 cytidine deaminase activity 2/5838 12/18639 0.166666666666667 0.532117163412127 0.92878773800012 1 GO:0005436 sodium:phosphate symporter activity 2/5838 12/18639 0.166666666666667 0.532117163412127 0.92878773800012 1 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 2/5838 12/18639 0.166666666666667 0.532117163412127 0.92878773800012 1 GO:0010853 cyclase activator activity 2/5838 12/18639 0.166666666666667 0.532117163412127 0.92878773800012 1 GO:0015166 polyol transmembrane transporter activity 2/5838 12/18639 0.166666666666667 0.532117163412127 0.92878773800012 1 GO:0070008 serine-type exopeptidase activity 2/5838 12/18639 0.166666666666667 0.532117163412127 0.92878773800012 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 2/5838 12/18639 0.166666666666667 0.532117163412127 0.92878773800012 1 GO:0140900 chloride:bicarbonate antiporter activity 2/5838 12/18639 0.166666666666667 0.532117163412127 0.92878773800012 1 GO:0005416 amino acid:monoatomic cation symporter activity 6/5838 29/18639 0.206896551724138 0.660559237339193 0.92945945783953 1 GO:0030296 protein tyrosine kinase activator activity 7/5838 33/18639 0.212121212121212 0.67724002616089 0.929848688398949 1 GO:0015662 P-type ion transporter activity 5/5838 25/18639 0.2 0.638540596094553 0.930161291515584 1 GO:0140358 P-type transmembrane transporter activity 5/5838 25/18639 0.2 0.638540596094553 0.930161291515584 1 GO:0030551 cyclic nucleotide binding 8/5838 37/18639 0.216216216216216 0.690314157940057 0.930945234051564 1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 4/5838 21/18639 0.19047619047619 0.608133901042431 0.932575883067587 1 GO:0061891 calcium ion sensor activity 4/5838 21/18639 0.19047619047619 0.608133901042431 0.932575883067587 1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/5838 17/18639 0.176470588235294 0.563418173024606 0.937764047572481 1 GO:0009881 photoreceptor activity 3/5838 17/18639 0.176470588235294 0.563418173024606 0.937764047572481 1 GO:0016805 dipeptidase activity 3/5838 17/18639 0.176470588235294 0.563418173024606 0.937764047572481 1 GO:0045125 bioactive lipid receptor activity 3/5838 17/18639 0.176470588235294 0.563418173024606 0.937764047572481 1 GO:0045236 CXCR chemokine receptor binding 3/5838 17/18639 0.176470588235294 0.563418173024606 0.937764047572481 1 GO:0001637 G protein-coupled chemoattractant receptor activity 5/5838 26/18639 0.192307692307692 0.613981342398609 0.944425529415809 1 GO:0004950 chemokine receptor activity 5/5838 26/18639 0.192307692307692 0.613981342398609 0.944425529415809 1 GO:0042626 ATPase-coupled transmembrane transporter activity 24/5838 98/18639 0.244897959183673 0.781886444197412 0.944620861901477 1 GO:0004180 carboxypeptidase activity 10/5838 46/18639 0.217391304347826 0.694065865320166 0.945093748258721 1 GO:0072341 modified amino acid binding 22/5838 91/18639 0.241758241758242 0.771862259015394 0.946530739308198 1 GO:0005243 gap junction channel activity 4/5838 22/18639 0.181818181818182 0.580491450995048 0.947358306775371 1 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/5838 22/18639 0.181818181818182 0.580491450995048 0.947358306775371 1 GO:0140784 metal ion sensor activity 4/5838 22/18639 0.181818181818182 0.580491450995048 0.947358306775371 1 GO:0008417 fucosyltransferase activity 2/5838 13/18639 0.153846153846154 0.491185073918887 0.947657887979791 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/5838 13/18639 0.153846153846154 0.491185073918887 0.947657887979791 1 GO:0071837 HMG box domain binding 2/5838 13/18639 0.153846153846154 0.491185073918887 0.947657887979791 1 GO:0089720 caspase binding 2/5838 13/18639 0.153846153846154 0.491185073918887 0.947657887979791 1 GO:1901338 catecholamine binding 2/5838 13/18639 0.153846153846154 0.491185073918887 0.947657887979791 1 GO:0000400 four-way junction DNA binding 3/5838 18/18639 0.166666666666667 0.532117163412127 0.952663212015727 1 GO:0015280 ligand-gated sodium channel activity 3/5838 18/18639 0.166666666666667 0.532117163412127 0.952663212015727 1 GO:0016854 racemase and epimerase activity 3/5838 18/18639 0.166666666666667 0.532117163412127 0.952663212015727 1 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 3/5838 18/18639 0.166666666666667 0.532117163412127 0.952663212015727 1 GO:0005245 voltage-gated calcium channel activity 9/5838 43/18639 0.209302325581395 0.668240158703602 0.953593286255979 1 GO:0005504 fatty acid binding 10/5838 47/18639 0.212765957446809 0.679298506483567 0.954258377133781 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 16/5838 70/18639 0.228571428571429 0.729760681250918 0.954839525841338 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 5/5838 27/18639 0.185185185185185 0.591241292680142 0.956000335317565 1 GO:0008331 high voltage-gated calcium channel activity 2/5838 14/18639 0.142857142857143 0.456100425781824 0.961695343852943 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/5838 14/18639 0.142857142857143 0.456100425781824 0.961695343852943 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2/5838 14/18639 0.142857142857143 0.456100425781824 0.961695343852943 1 GO:1901474 azole transmembrane transporter activity 2/5838 14/18639 0.142857142857143 0.456100425781824 0.961695343852943 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 9/5838 44/18639 0.204545454545455 0.653052882369429 0.96175699231385 1 GO:0004190 aspartic-type endopeptidase activity 7/5838 36/18639 0.194444444444444 0.620803357314149 0.962299076971441 1 GO:0015106 bicarbonate transmembrane transporter activity 6/5838 32/18639 0.1875 0.598631808838643 0.963400885804737 1 GO:0022840 leak channel activity 3/5838 19/18639 0.157894736842105 0.504110996916752 0.964172438488138 1 GO:0022842 narrow pore channel activity 3/5838 19/18639 0.157894736842105 0.504110996916752 0.964172438488138 1 GO:0042834 peptidoglycan binding 3/5838 19/18639 0.157894736842105 0.504110996916752 0.964172438488138 1 GO:0061135 endopeptidase regulator activity 47/5838 184/18639 0.255434782608696 0.815527391751195 0.964258461595956 1 GO:0005242 inward rectifier potassium channel activity 5/5838 28/18639 0.178571428571429 0.570125532227279 0.965329730108912 1 GO:0008081 phosphoric diester hydrolase activity 20/5838 87/18639 0.229885057471264 0.733954708154659 0.966733305253345 1 GO:0001664 G protein-coupled receptor binding 79/5838 297/18639 0.265993265993266 0.849237493122385 0.967977046608613 1 GO:0004806 triacylglycerol lipase activity 4/5838 24/18639 0.166666666666667 0.532117163412127 0.968391013900023 1 GO:0008137 NADH dehydrogenase (ubiquinone) activity 8/5838 41/18639 0.195121951219512 0.622966435214198 0.968907757123853 1 GO:0070001 aspartic-type peptidase activity 7/5838 37/18639 0.189189189189189 0.60402488819755 0.969614973652745 1 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/5838 15/18639 0.133333333333333 0.425693730729702 0.97207572722626 1 GO:0008242 omega peptidase activity 2/5838 15/18639 0.133333333333333 0.425693730729702 0.97207572722626 1 GO:0015116 sulfate transmembrane transporter activity 2/5838 15/18639 0.133333333333333 0.425693730729702 0.97207572722626 1 GO:0140161 monocarboxylate:sodium symporter activity 2/5838 15/18639 0.133333333333333 0.425693730729702 0.97207572722626 1 GO:0004181 metallocarboxypeptidase activity 5/5838 29/18639 0.172413793103448 0.550466031115994 0.972802703498367 1 GO:0051861 glycolipid binding 5/5838 29/18639 0.172413793103448 0.550466031115994 0.972802703498367 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 9/5838 46/18639 0.195652173913043 0.62465927878815 0.974326540276905 1 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 12/5838 58/18639 0.206896551724138 0.660559237339193 0.974390584458152 1 GO:0001848 complement binding 4/5838 25/18639 0.16 0.510832476875642 0.975672865782773 1 GO:0015271 outward rectifier potassium channel activity 4/5838 25/18639 0.16 0.510832476875642 0.975672865782773 1 GO:0004935 adrenergic receptor activity 1/5838 10/18639 0.1 0.319270298047276 0.976679679783079 1 GO:0005345 purine nucleobase transmembrane transporter activity 1/5838 10/18639 0.1 0.319270298047276 0.976679679783079 1 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/5838 10/18639 0.1 0.319270298047276 0.976679679783079 1 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/5838 10/18639 0.1 0.319270298047276 0.976679679783079 1 GO:0019911 structural constituent of myelin sheath 1/5838 10/18639 0.1 0.319270298047276 0.976679679783079 1 GO:0032052 bile acid binding 1/5838 10/18639 0.1 0.319270298047276 0.976679679783079 1 GO:0042166 acetylcholine binding 1/5838 10/18639 0.1 0.319270298047276 0.976679679783079 1 GO:0043208 glycosphingolipid binding 1/5838 10/18639 0.1 0.319270298047276 0.976679679783079 1 GO:0141109 transporter activator activity 1/5838 10/18639 0.1 0.319270298047276 0.976679679783079 1 GO:0005149 interleukin-1 receptor binding 2/5838 16/18639 0.125 0.399087872559096 0.979712436919857 1 GO:0015378 sodium:chloride symporter activity 2/5838 16/18639 0.125 0.399087872559096 0.979712436919857 1 GO:0016722 oxidoreductase activity, acting on metal ions 2/5838 16/18639 0.125 0.399087872559096 0.979712436919857 1 GO:0001846 opsonin binding 3/5838 21/18639 0.142857142857143 0.456100425781824 0.979742835011294 1 GO:0015125 bile acid transmembrane transporter activity 3/5838 21/18639 0.142857142857143 0.456100425781824 0.979742835011294 1 GO:0033293 monocarboxylic acid binding 17/5838 79/18639 0.215189873417722 0.687037350228316 0.980390713799057 1 GO:0015145 monosaccharide transmembrane transporter activity 4/5838 26/18639 0.153846153846154 0.491185073918887 0.981354199667676 1 GO:0019865 immunoglobulin binding 4/5838 26/18639 0.153846153846154 0.491185073918887 0.981354199667676 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 20/5838 91/18639 0.21978021978022 0.701692962741267 0.981929501499626 1 GO:0003954 NADH dehydrogenase activity 8/5838 44/18639 0.181818181818182 0.580491450995048 0.9836056026985 1 GO:0001851 complement component C3b binding 1/5838 11/18639 0.0909090909090909 0.290245725497524 0.983987856788092 1 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/5838 11/18639 0.0909090909090909 0.290245725497524 0.983987856788092 1 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/5838 11/18639 0.0909090909090909 0.290245725497524 0.983987856788092 1 GO:0008503 benzodiazepine receptor activity 1/5838 11/18639 0.0909090909090909 0.290245725497524 0.983987856788092 1 GO:0015205 nucleobase transmembrane transporter activity 1/5838 11/18639 0.0909090909090909 0.290245725497524 0.983987856788092 1 GO:0016594 glycine binding 1/5838 11/18639 0.0909090909090909 0.290245725497524 0.983987856788092 1 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/5838 11/18639 0.0909090909090909 0.290245725497524 0.983987856788092 1 GO:1990948 ubiquitin ligase inhibitor activity 1/5838 11/18639 0.0909090909090909 0.290245725497524 0.983987856788092 1 GO:0015144 carbohydrate transmembrane transporter activity 7/5838 40/18639 0.175 0.558723021582734 0.984462073282212 1 GO:0033691 sialic acid binding 3/5838 22/18639 0.136363636363636 0.435368588246286 0.984856181574861 1 GO:0140517 protein-RNA adaptor activity 3/5838 22/18639 0.136363636363636 0.435368588246286 0.984856181574861 1 GO:0004896 cytokine receptor activity 21/5838 96/18639 0.21875 0.698403776978417 0.98500792410998 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/5838 17/18639 0.117647058823529 0.375612115349737 0.985305555499507 1 GO:0004175 endopeptidase activity 107/5838 405/18639 0.264197530864198 0.843504244223669 0.987205034279423 1 GO:0009055 electron transfer activity 26/5838 116/18639 0.224137931034483 0.715605840450792 0.987210514710082 1 GO:0015291 secondary active transmembrane transporter activity 73/5838 287/18639 0.254355400696864 0.812081245904222 0.988276056416014 1 GO:0031406 carboxylic acid binding 45/5838 187/18639 0.240641711229947 0.768297508669917 0.988557289656244 1 GO:0017171 serine hydrolase activity 48/5838 198/18639 0.242424242424242 0.773988601326731 0.988712755492352 1 GO:0005212 structural constituent of eye lens 3/5838 23/18639 0.130434782608696 0.4164395191921 0.988717957121569 1 GO:0016917 GABA receptor activity 3/5838 23/18639 0.130434782608696 0.4164395191921 0.988717957121569 1 GO:0022829 wide pore channel activity 6/5838 37/18639 0.162162162162162 0.517735618455043 0.988736166576806 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/5838 12/18639 0.0833333333333333 0.266058581706064 0.98900604940518 1 GO:0015085 calcium ion transmembrane transporter activity 34/5838 147/18639 0.231292517006803 0.738448308408667 0.989066620917121 1 GO:0015171 amino acid transmembrane transporter activity 22/5838 102/18639 0.215686274509804 0.688622211474518 0.989373676240931 1 GO:0015373 monoatomic anion:sodium symporter activity 2/5838 18/18639 0.111111111111111 0.354744775608085 0.989385848434979 1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/5838 18/18639 0.111111111111111 0.354744775608085 0.989385848434979 1 GO:0022851 GABA-gated chloride ion channel activity 2/5838 18/18639 0.111111111111111 0.354744775608085 0.989385848434979 1 GO:0004867 serine-type endopeptidase inhibitor activity 20/5838 95/18639 0.210526315789474 0.672147995889003 0.990554315562257 1 GO:0043177 organic acid binding 45/5838 189/18639 0.238095238095238 0.760167376303039 0.991031349157325 1 GO:0005272 sodium channel activity 9/5838 51/18639 0.176470588235294 0.563418173024606 0.991079526006357 1 GO:0099095 ligand-gated monoatomic anion channel activity 8/5838 47/18639 0.170212765957447 0.543438805186854 0.991619135465532 1 GO:0005540 hyaluronic acid binding 3/5838 24/18639 0.125 0.399087872559096 0.991621806153218 1 GO:0015149 hexose transmembrane transporter activity 3/5838 24/18639 0.125 0.399087872559096 0.991621806153218 1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/5838 24/18639 0.125 0.399087872559096 0.991621806153218 1 GO:0055056 D-glucose transmembrane transporter activity 3/5838 24/18639 0.125 0.399087872559096 0.991621806153218 1 GO:0008514 organic anion transmembrane transporter activity 67/5838 269/18639 0.24907063197026 0.795208549039685 0.991646099318619 1 GO:0042379 chemokine receptor binding 14/5838 72/18639 0.194444444444444 0.620803357314149 0.991702173108459 1 GO:0004890 GABA-A receptor activity 2/5838 19/18639 0.105263157894737 0.336073997944502 0.992352131958137 1 GO:0015020 glucuronosyltransferase activity 5/5838 34/18639 0.147058823529412 0.469515144187171 0.992378881697406 1 GO:0004465 lipoprotein lipase activity 1/5838 13/18639 0.0769230769230769 0.245592536959443 0.992451729523962 1 GO:0015293 symporter activity 33/5838 146/18639 0.226027397260274 0.721638344901378 0.992497312961804 1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/5838 25/18639 0.12 0.383124357656732 0.993796661658279 1 GO:0005326 neurotransmitter transmembrane transporter activity 2/5838 20/18639 0.1 0.319270298047276 0.994501846729115 1 GO:0015464 acetylcholine receptor activity 2/5838 20/18639 0.1 0.319270298047276 0.994501846729115 1 GO:0046982 protein heterodimerization activity 94/5838 369/18639 0.254742547425474 0.813317290418536 0.994512804037583 1 GO:0046906 tetrapyrrole binding 34/5838 152/18639 0.223684210526316 0.714157245632066 0.994547300500496 1 GO:0071855 neuropeptide receptor binding 6/5838 40/18639 0.15 0.478905447070915 0.994674809724182 1 GO:0005344 oxygen carrier activity 1/5838 14/18639 0.0714285714285714 0.228050212890912 0.99481760534481 1 GO:0043176 amine binding 1/5838 14/18639 0.0714285714285714 0.228050212890912 0.99481760534481 1 GO:0008236 serine-type peptidase activity 45/5838 194/18639 0.231958762886598 0.740575433614816 0.995239208145652 1 GO:0008009 chemokine activity 7/5838 45/18639 0.155555555555556 0.496642685851319 0.995254913534822 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 5/5838 36/18639 0.138888888888889 0.443430969510106 0.995524504142852 1 GO:0015103 inorganic anion transmembrane transporter activity 37/5838 165/18639 0.224242424242424 0.715939456227226 0.995729756779547 1 GO:0005262 calcium channel activity 28/5838 131/18639 0.213740458015267 0.682409797352957 0.995848086655564 1 GO:0001530 lipopolysaccharide binding 6/5838 41/18639 0.146341463414634 0.467224826410648 0.995876588678393 1 GO:0015294 solute:monoatomic cation symporter activity 24/5838 116/18639 0.206896551724138 0.660559237339193 0.996171992082521 1 GO:0004129 cytochrome-c oxidase activity 1/5838 15/18639 0.0666666666666667 0.212846865364851 0.996442025210421 1 GO:0008020 G protein-coupled photoreceptor activity 1/5838 15/18639 0.0666666666666667 0.212846865364851 0.996442025210421 1 GO:0015250 water channel activity 1/5838 15/18639 0.0666666666666667 0.212846865364851 0.996442025210421 1 GO:0005104 fibroblast growth factor receptor binding 3/5838 27/18639 0.111111111111111 0.354744775608085 0.996626594495941 1 GO:0008509 monoatomic anion transmembrane transporter activity 32/5838 149/18639 0.214765100671141 0.685681177014285 0.997244820381461 1 GO:0020037 heme binding 30/5838 142/18639 0.211267605633803 0.674514714184387 0.997529213176028 1 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/5838 16/18639 0.0625 0.199543936279548 0.997557331096458 1 GO:0022841 potassium ion leak channel activity 1/5838 16/18639 0.0625 0.199543936279548 0.997557331096458 1 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/5838 16/18639 0.0625 0.199543936279548 0.997557331096458 1 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/5838 16/18639 0.0625 0.199543936279548 0.997557331096458 1 GO:0030414 peptidase inhibitor activity 37/5838 169/18639 0.218934911242604 0.698994143653801 0.997602060586939 1 GO:0046943 carboxylic acid transmembrane transporter activity 42/5838 188/18639 0.223404255319149 0.713263431807745 0.997638682746721 1 GO:0005253 monoatomic anion channel activity 20/5838 103/18639 0.194174757281553 0.619942326305391 0.997674972068237 1 GO:0015370 solute:sodium symporter activity 14/5838 79/18639 0.177215189873418 0.565795464893908 0.997943012457947 1 GO:0005342 organic acid transmembrane transporter activity 42/5838 189/18639 0.222222222222222 0.70948955121617 0.99794960571006 1 GO:0019825 oxygen binding 4/5838 34/18639 0.117647058823529 0.375612115349737 0.998030350673451 1 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 8/5838 54/18639 0.148148148148148 0.472993034144113 0.998418363179467 1 GO:0004252 serine-type endopeptidase activity 38/5838 176/18639 0.215909090909091 0.68933359805662 0.998507831165882 1 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/5838 24/18639 0.0833333333333333 0.266058581706064 0.998558909516259 1 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/5838 24/18639 0.0833333333333333 0.266058581706064 0.998558909516259 1 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/5838 24/18639 0.0833333333333333 0.266058581706064 0.998558909516259 1 GO:0004866 endopeptidase inhibitor activity 34/5838 161/18639 0.211180124223602 0.674235412025304 0.998588230375352 1 GO:0004970 glutamate-gated receptor activity 1/5838 18/18639 0.0555555555555556 0.177372387804042 0.998848785814579 1 GO:0005372 water transmembrane transporter activity 1/5838 18/18639 0.0555555555555556 0.177372387804042 0.998848785814579 1 GO:0032393 MHC class I receptor activity 1/5838 18/18639 0.0555555555555556 0.177372387804042 0.998848785814579 1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/5838 18/18639 0.0555555555555556 0.177372387804042 0.998848785814579 1 GO:0034987 immunoglobulin receptor binding 1/5838 19/18639 0.0526315789473684 0.168036998972251 0.999209711028826 1 GO:0015108 chloride transmembrane transporter activity 23/5838 121/18639 0.190082644628099 0.606877426040278 0.999213103473676 1 GO:0001614 purinergic nucleotide receptor activity 1/5838 20/18639 0.05 0.159635149023638 0.999457493360389 1 GO:0016502 nucleotide receptor activity 1/5838 20/18639 0.05 0.159635149023638 0.999457493360389 1 GO:0030627 pre-mRNA 5'-splice site binding 1/5838 20/18639 0.05 0.159635149023638 0.999457493360389 1 GO:0140375 immune receptor activity 31/5838 156/18639 0.198717948717949 0.634447387145229 0.999533308159764 1 GO:0099094 ligand-gated monoatomic cation channel activity 26/5838 136/18639 0.191176470588235 0.610369687443323 0.999534345896631 1 GO:0015081 sodium ion transmembrane transporter activity 33/5838 164/18639 0.201219512195122 0.642434136314642 0.999540249868152 1 GO:0005254 chloride channel activity 13/5838 83/18639 0.156626506024096 0.500061912604168 0.999664589070974 1 GO:0015399 primary active transmembrane transporter activity 33/5838 166/18639 0.198795180722892 0.634693965997598 0.999672423516618 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 3/5838 36/18639 0.0833333333333333 0.266058581706064 0.999803853721835 1 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 9/5838 68/18639 0.132352941176471 0.422563629768454 0.999850743573041 1 GO:0005184 neuropeptide hormone activity 2/5838 31/18639 0.0645161290322581 0.205980837449856 0.9998689229453 1 GO:0160041 neuropeptide activity 2/5838 32/18639 0.0625 0.199543936279548 0.999907329290846 1 GO:0005251 delayed rectifier potassium channel activity 1/5838 25/18639 0.04 0.127708119218911 0.99991733133817 1 GO:0008066 glutamate receptor activity 1/5838 26/18639 0.0384615384615385 0.122796268479722 0.999943259115529 1 GO:0015079 potassium ion transmembrane transporter activity 29/5838 160/18639 0.18125 0.578677415210689 0.999948178328046 1 GO:0022804 active transmembrane transporter activity 106/5838 457/18639 0.231947483588621 0.740539422166549 0.99995984652603 1 GO:0015252 proton channel activity 1/5838 27/18639 0.037037037037037 0.118248258536028 0.999961055993171 1 GO:0008227 G protein-coupled amine receptor activity 3/5838 41/18639 0.0731707317073171 0.233612413205324 0.999961740394213 1 GO:0003823 antigen binding 32/5838 174/18639 0.183908045977011 0.587163766523727 0.999962132083511 1 GO:0005125 cytokine activity 46/5838 234/18639 0.196581196581197 0.627625372229689 0.999979877307249 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 5/5838 56/18639 0.0892857142857143 0.28506276611364 0.999986578624508 1 GO:0005267 potassium channel activity 19/5838 124/18639 0.153225806451613 0.489204488943408 0.999987177502442 1 GO:0008528 G protein-coupled peptide receptor activity 18/5838 122/18639 0.147540983606557 0.471054538102539 0.999992742016508 1 GO:0022853 active monoatomic ion transmembrane transporter activity 17/5838 118/18639 0.144067796610169 0.459965683627432 0.999993606661073 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 4/5838 53/18639 0.0754716981132075 0.240958715507378 0.999994435790044 1 GO:0005249 voltage-gated potassium channel activity 12/5838 98/18639 0.122448979591837 0.390943222098706 0.999997373040256 1 GO:0001653 peptide receptor activity 18/5838 128/18639 0.140625 0.448973856628983 0.999998240840288 1 GO:0015276 ligand-gated monoatomic ion channel activity 31/5838 186/18639 0.166666666666667 0.532117163412127 0.999998449001511 1 GO:0022824 transmitter-gated monoatomic ion channel activity 5/5838 63/18639 0.0793650793650794 0.253389125434346 0.999998475475934 1 GO:0022835 transmitter-gated channel activity 5/5838 63/18639 0.0793650793650794 0.253389125434346 0.999998475475934 1 GO:0098960 postsynaptic neurotransmitter receptor activity 6/5838 69/18639 0.0869565217391304 0.277626346128066 0.9999985926474 1 GO:0022843 voltage-gated monoatomic cation channel activity 21/5838 143/18639 0.146853146853147 0.468858479649847 0.999998711014706 1 GO:0046873 metal ion transmembrane transporter activity 97/5838 450/18639 0.215555555555556 0.688204864679685 0.99999884557005 1 GO:0022832 voltage-gated channel activity 28/5838 175/18639 0.16 0.510832476875642 0.999998968593351 1 GO:0022834 ligand-gated channel activity 31/5838 188/18639 0.164893617021277 0.526456342524764 0.999998976341501 1 GO:0030280 structural constituent of skin epidermis 1/5838 37/18639 0.027027027027027 0.0862892697425072 0.999999097807479 1 GO:0015078 proton transmembrane transporter activity 30/5838 185/18639 0.162162162162162 0.517735618455043 0.999999222696417 1 GO:0005244 voltage-gated monoatomic ion channel activity 27/5838 173/18639 0.15606936416185 0.498283124120027 0.999999384086765 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 6/5838 73/18639 0.0821917808219178 0.262413943600501 0.999999588193507 1 GO:0003730 mRNA 3'-UTR binding 47/5838 262/18639 0.179389312977099 0.572736794206946 0.999999730742588 1 GO:0003735 structural constituent of ribosome 24/5838 175/18639 0.137142857142857 0.437856408750551 0.999999982810765 1 GO:0008188 neuropeptide receptor activity 1/5838 48/18639 0.0208333333333333 0.0665146454265159 0.999999985697553 1 GO:0005261 monoatomic cation channel activity 62/5838 341/18639 0.181818181818182 0.580491450995048 0.999999989438016 1 GO:0030594 neurotransmitter receptor activity 7/5838 97/18639 0.0721649484536082 0.230401246013498 0.999999998575941 1 GO:0005179 hormone activity 12/5838 132/18639 0.0909090909090909 0.290245725497524 0.999999999804103 1 GO:0005216 monoatomic ion channel activity 81/5838 448/18639 0.180803571428571 0.57725210138012 0.999999999952764 1 GO:0022836 gated channel activity 49/5838 318/18639 0.154088050314465 0.491957377494231 0.999999999984026 1 GO:0030371 translation repressor activity 14/5838 329/18639 0.0425531914893617 0.135859701296713 1 1 GO:0045182 translation regulator activity 22/5838 356/18639 0.0617977528089888 0.197301869579778 1 1