category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	33/404	233/9376	3.28695873879233	TPM1/FN1/ITGA5/COL4A2/COL4A1/FMNL2/FBN1/SYNE2/ITGB1/DSP/THBS1/FBLN1/HSPG2/COL27A1/DIAPH1/DES/ACTG2/MYH11/FBN2/PKP2/TNNI2/PDLIM3/THBS3/MYH9/BGN/SDC4/SYNE1/MYH10/DSG2/PDLIM5/DAG1/ENO1/LMOD1	7.50107690470371
NA	NA	hsa04518	Integrin signaling	26/404	154/9376	3.91822039346792	FLT1/FN1/ITGA5/COL4A2/COL4A1/FBN1/ITGB1/VEGFA/FLNB/LAMB1/PIK3CB/LAMA3/THBS1/EGFR/LAMB3/TNC/PIK3R1/PDGFD/CDH1/AKT3/PTK2/ACTN1/FERMT2/THBS3/ACTN4/TGFB1	7.74814211553923
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	29/404	204/9376	3.29916521063871	TIMP3/FN1/ITGA5/EZR/ITGB1/VEGFA/CTSL/PIK3CB/THBS1/EGFR/HSPG2/PIK3R1/FGFR1/IGF2/TIAM1/AKT3/PPP1R12B/PTK2/CAMK2G/RRAS2/VAV2/PLCG2/SDC4/CD44/TGFB2/GPC1/EIF4B/WNT5A/TGFB1	7.04506376682607
NA	NA	hsa04517	IgSF CAM signaling	36/404	299/9376	2.79426471075201	RASA1/ITGA5/EZR/FOXO1/IL1RAP/ITGB1/TRIO/PTPRF/PIK3CB/SORBS1/PIK3R1/PARD3/FGFR1/GRIP1/CDH1/RAPGEF2/AKT3/NLGN1/PTK2/MYH11/KCNQ3/F11R/VAV2/ACTN1/CLMP/ACTR3C/TJP2/MYH9/TJP1/AFDN/JAM2/PLCG2/ACTN4/MYH10/MAGI2/NECTIN4	6.6908705928708
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/404	101/9376	4.13606509165768	SERPINE1/FN1/COL4A2/COL4A1/FOXO1/VEGFA/PIK3CB/PIK3R1/DIAPH1/AKT3/SMAD3/F3/PLCG2/PRKCZ/TGFB2/PRKCE/JAK2/TGFB1	6.7238882094362
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	26/404	203/9376	2.97244305711359	FLT1/FN1/ITGA5/COL4A2/COL4A1/ITGB1/VEGFA/FLNB/LAMB1/PIK3CB/LAMA3/THBS1/EGFR/LAMB3/TNC/PIK3R1/PDGFD/DIAPH1/AKT3/PPP1R12B/PTK2/VAV2/ACTN1/THBS3/ACTN4/DOCK1	6.02876679541293
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	23/404	170/9376	3.13989516598719	EZR/ITGB1/PARD3/TIAM1/RAPGEF2/CLDN4/PRKAG2/RAB8B/MYH11/F11R/PATJ/ACTN1/CLDN19/ACTR3C/TJP2/MYH9/TJP1/AFDN/JAM2/PRKCZ/ACTN4/MYH10/PRKCE	5.9746595247811
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	27/404	232/9376	2.70092181631956	FN1/ITGA5/EZR/ITGB1/PIK3CB/SSH2/EGFR/PIK3R1/PDGFD/FGFR1/DIAPH1/TIAM1/KNG1/AKT3/PPP1R12B/PTK2/MYH11/RRAS2/VAV2/ACTN1/ARHGEF7/LPAR1/ACTR3C/MYH9/ACTN4/MYH10/DOCK1	5.56662445988938
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	17/404	110/9376	3.58667866786679	SERPINE1/FLT1/TF/INSR/EPAS1/VEGFA/PIK3CB/EGFR/PIK3R1/ALDOB/AKT3/CAMK2G/HK2/PLCG2/LDHA/EGLN3/ENO1	5.79061064593646
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	15/404	89/9376	3.91144732450773	FN1/ITGA5/COL4A2/COL4A1/ITGB1/LAMB1/LAMA3/THBS1/LAMB3/HSPG2/TNC/THBS3/SDC4/CD44/DAG1	5.8559573615207
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	14/404	93/9376	3.49366549558182	TCF7L2/INSR/PTPRF/EGFR/SORBS1/PARD3/FGFR1/CDH1/SMAD3/ACTN1/TJP1/AFDN/ACTN4/NECTIN4	5.1282263212566
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	14/404	93/9376	3.49366549558182	FN1/COL4A2/COL4A1/ITGB1/LAMB1/PIK3CB/LAMA3/LAMB3/PIK3R1/PTGS2/AKT3/PTK2/BIRC7/NFKBIA	5.1282263212566
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	23/404	212/9376	2.51784046329161	FLT1/ITGB1/INSR/VEGFA/PIK3CB/THBS1/EGFR/PIK3R1/PDGFD/PARD3/FGFR1/TIAM1/CDH1/RAPGEF2/AKT3/VAV2/LPAR1/CNR1/AFDN/PRKCZ/MAGI2/EVL/EFNA4	4.74332852122435
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	22/404	200/9376	2.55287128712871	EZR/TNFSF10/ITGB1/BAIAP2L1/MYO1E/CLDN4/IL1R1/MYH11/CLDN19/LPAR1/MYO6/MYO5B/ACTR3C/MYH9/TJP1/WIPF1/NCL/CYTH3/NFKBIA/MYH10/FOS/ARF1	4.71037456824106
NA	NA	hsa04519	Cadherin signaling	35/404	404/9376	2.01058719733359	TEAD1/TCF7L2/WWTR1/DSP/EGFR/FGFR1/LIMA1/PTK2B/KRT8/CDH1/MYO1E/DES/KRT6A/YWHAZ/PTK2/RRAS2/KRT19/PKP2/VAV2/ACTN1/FAT1/CTNND2/ANKRD6/ACTR3C/TJP1/AFDN/PCDH7/KRT7/ACTN4/NFKBIA/TMC1/AXIN1/DSG2/WNT5A/EVL	4.40607139881306
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	15/404	109/9376	3.19375056771732	FOXO1/INSR/PTPRF/PIK3CB/PIK3R1/CREB3L2/CREB5/AKT3/PRKAG2/IRS2/CPT1B/PRKCZ/NFKBIA/RPS6KA6/PRKCE	4.88835347409166
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	32/404	362/9376	2.05152890979706	FLT1/FN1/ITGA5/COL4A2/COL4A1/ITGB1/INSR/VEGFA/LAMB1/PIK3CB/LAMA3/THBS1/EGFR/LAMB3/TNC/PIK3R1/PDGFD/FGFR1/CREB3L2/IGF2/CREB5/AKT3/YWHAZ/PTK2/LPAR1/JAK1/THBS3/EIF4B/JAK2/MAGI2/HSP90B1/EFNA4	4.32960637109276
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	30/404	333/9376	2.09080367496209	HLA-G/FN1/ITGA5/TCF7L2/COL4A2/COL4A1/FOXO1/ITGB1/VEGFA/LAMB1/PIK3CB/LAMA3/THBS1/EGFR/LAMB3/TNC/PIK3R1/PARD3/CREB3L2/PTGS2/CREB5/AKT3/PTK2/PATJ/JAK1/THBS3/PRKCZ/AXIN1/CHD4/WNT5A	4.30074934689064
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/404	103/9376	3.15447467076805	FN1/COL4A2/COL4A1/LAMB1/PIK3CB/LAMA3/LAMB3/PIK3R1/IL1R1/PTK2/ACTN1/ACTN4/TGFB2/TGFB1	4.66532134824838
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	15/404	116/9376	3.00102424035507	EZR/ITGB1/PIK3CB/PIK3R1/PTK2B/CLDN4/PTK2/F11R/VAV2/ACTN1/CLDN19/AFDN/JAM2/PLCG2/ACTN4	4.60158595988207
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	23/404	238/9376	2.24278226141942	FLT1/RASA1/INSR/VEGFA/PIK3CB/EGFR/RASGRF2/PLA2G5/RASAL2/PIK3R1/PDGFD/FGFR1/PLA2G4A/IGF2/TIAM1/ETS2/AKT3/RRAS2/AFDN/PLCG2/PLA2G2A/EFNA4/KSR1	4.12087684721726
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	16/404	138/9376	2.6907734251686	FN1/ITGA5/ITGB1/PIK3CB/PIK3R1/PTK2B/AKT3/PTK2/VAV2/ARHGEF7/ACTR3C/WIPF1/NFKBIA/RPS6KA6/FOS/DOCK1	4.24587951151085
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	11/404	78/9376	3.27291190657527	FN1/ITGA5/ITGB1/PIK3CB/PIK3R1/CDH1/PTK2/CLTB/ACTR3C/ARHGAP10/DOCK1	4.27727154345038
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/404	17/9376	6.82585905649388	MYH11/MYH9/PCDH7/MYH10/DAG1	5.10154120745
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	15/404	133/9376	2.61743467579841	TNFSF10/FOXO1/INSR/HOMER1/PIK3CB/FBXO32/EGFR/PIK3R1/AKT3/PRKAG2/SMAD3/IRS2/TGFB2/GABARAPL1/TGFB1	3.98637161591847
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	13/404	106/9376	2.84625443676443	TCF7L2/FOXO1/PIK3CB/EGFR/PIK3R1/PDGFD/FGFR1/CREB3L2/CREB5/AKT3/NFKBIA/HSP90B1/SPINT1	4.05635826628002
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	17/404	163/9376	2.42045799671992	PIK3CB/HSPG2/PIK3R1/CREB3L2/PTK2B/CREB5/AKT3/YWHAZ/SMAD3/JAK1/NFKBIA/TGFB2/FOS/JAK2/NFATC4/DDB1/TGFB1	3.8819805131616
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	13/404	112/9376	2.69377652050919	ITGB1/LAMB1/LAMA3/LAMB3/AKT3/LDLR/BIRC7/JAK1/HSPA1B/NFKBIA/TGFB2/JAK2/TGFB1	3.82646314501946
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	16/404	157/9376	2.36513842467049	SERPINE1/TEAD1/TCF7L2/WWTR1/PARD3/BMP2/CDH1/YWHAZ/SMAD3/PATJ/PRKCZ/TGFB2/AXIN1/DLG5/WNT5A/TGFB1	3.6602967646539
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	25/404	300/9376	1.93399339933993	FLT1/RASA1/IL1RAP/INSR/VEGFA/EGFR/RASGRF2/PDGFD/FGFR1/PLA2G4A/IGF2/RAPGEF2/AKT3/IL1R1/DUSP1/RRAS2/MAP3K9/MAPK8IP3/CACNB2/HSPA1B/TGFB2/RPS6KA6/FOS/TGFB1/EFNA4	3.48890287068778
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	22/404	253/9376	2.01808006887645	ITGA5/FOXO1/ITGB1/PIK3CB/EGFR/PIK3R1/DIAPH1/AKT3/IL1R1/PTK2/HK2/ACTN1/ACTR3C/PLCG2/CYTH3/ACTN4/NFKBIA/CD44/PRKCE/DOCK1/ARF1/FNBP1L	3.48341362921558
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/404	52/9376	3.57044935262757	APOA2/APOC3/APOB/APOA1/LDLR/APOC2/APOH/ABCA1	3.94403970861341
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	10/404	80/9376	2.9009900990099	VEGFA/PIK3CB/EGFR/PIK3R1/PDGFD/AKT3/NRG2/JAK1/PLCG2/JAK2	3.62333491706529
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	12/404	109/9376	2.55500045417386	IL1RAP/GATA3/IL6ST/EBI3/IL1R1/SMAD3/JAK1/RORA/NFKBIA/FOS/JAK2/TGFB1	3.46502103941763
NA	NA	hsa04382	Cornified envelope formation	19/404	217/9376	2.03202993110371	PCSK6/COL4A2/COL4A1/DSP/COL17A1/LAMA3/LAMB3/KRT8/CLDN4/KRT6A/KRT19/PKP2/CLDN19/PRSS8/TJP1/KRT7/COL7A1/DSG2/SPRR2G	3.26384720004653
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	9/404	71/9376	2.94184911448891	PIK3CB/EGFR/PIK3R1/FGFR1/AKT3/HK2/LDHA/SLC16A3/GLS	3.48512336164395
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	14/404	144/9376	2.25632563256326	INHBA/PIK3CB/IL6ST/PIK3R1/FGFR1/AKT3/SMAD3/JAK1/ID4/LEFTY2/LIFR/AXIN1/JAK2/WNT5A	3.22379381047653
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/404	47/9376	3.4564988413735	INSR/PIK3CB/PIK3R1/IRS2/HK2/PRKCZ/PRKCE	3.58244584806726
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	13/404	130/9376	2.32079207920792	COL4A2/COL4A1/VEGFA/PIK3CB/EGFR/PIK3R1/CREB3L2/CREB5/AKT3/PRKCZ/NFKBIA/FOS/TGFB1	3.21781354677024
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/404	60/9376	3.09438943894389	VEGFA/PIK3CB/PIK3R1/PLA2G4A/PTGS2/AKT3/PTK2/PLCG2	3.45342487435064
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/404	36/9376	3.86798679867987	GALNT15/B4GALT5/GALNT2/GALNT6/GCNT1/GALNT17	3.65836175744751
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	10/404	87/9376	2.66757710253784	TCF7L2/PIK3CB/EGFR/PIK3R1/AKT3/SMAD3/TGFB2/AXIN1/FOS/TGFB1	3.31583381646589
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/404	62/9376	2.99457042478441	FOXO1/INSR/PIK3CB/PIK3R1/AKT3/PRKAG2/IRS2/HSPA1B	3.34355746206061
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	14/404	149/9376	2.18061000730946	INSR/PIK3CB/EGFR/PIK3R1/PDGFD/PLA2G4A/PTK2B/AKT3/RRAS2/DGKI/LPAR1/PLCG2/CYTH3/ARF1	3.08248535802448
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	12/404	119/9376	2.34029453365505	TNFAIP3/PIK3CB/PIK3R1/CREB3L2/PTGS2/CREB5/CEBPB/AKT3/DAB2IP/MMP14/NFKBIA/FOS	3.12226875817875
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	10/404	90/9376	2.57865786578658	FOXO1/INSR/PIK3CB/PIK3R1/CREB3L2/CREB5/AKT3/PRKAG2/IRS2/SESN1	3.19320368074554
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/404	50/9376	3.24910891089109	SAT1/AOC1/CKB/MAOA/P4HA1/AMD1/MAOB	3.38360354374772
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	9/404	77/9376	2.71261411855471	VEGFA/PIK3CB/EGFR/PIK3R1/AKT3/SMAD3/JAK1/TGFB2/TGFB1	3.20197876184208
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	16/404	184/9376	2.01808006887645	RASA1/ITGB1/PIK3CB/SSH2/SEMA5A/PIK3R1/PARD3/SEMA6D/PTK2/CAMK2G/EPHB2/PLCG2/PRKCZ/NFATC4/WNT5A/EFNA4	2.95949443208187
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	13/404	138/9376	2.18625340794949	FOXO1/INSR/PTPRF/PIK3CB/SORBS1/PIK3R1/PRKAR2B/AKT3/PRKAG2/CBLB/IRS2/HK2/PRKCZ	2.97892607329714
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	13/404	139/9376	2.17052496616568	PIK3CB/FKBP5/EGFR/NCOA1/PIK3R1/CREB3L2/CREB5/AKT3/KRT19/GREB1/HSPA1B/FOS/HSP90B1	2.950219286684
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	11/404	110/9376	2.32079207920792	FBN1/TF/INHBA/THBS1/LTBP1/BMP2/SMAD3/ID4/LEFTY2/TGFB2/TGFB1	2.95676180035046
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	14/404	157/9376	2.06949612158668	THBS1/PTGS2/CEBPB/PTK2/CAMK2G/MFGE8/CPT1B/ANO9/ABCA1/ATP11A/JAK2/NFATC4/TGFB1/DOCK1	2.86760164603711
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	13/404	142/9376	2.12466880490866	VEGFA/CTSL/PIK3CB/PIK3R1/AKT3/IL1R1/DUSP1/PTK2/SDC4/PRKCZ/FOS/GPC1/HSP90B1	2.86553405814298
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/404	55/9376	2.95373537353735	HEXB/CERS6/B4GALT5/SGMS2/SGPP1/CERS5/PSAP	3.08352531899491
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/404	98/9376	2.36815518286523	PIK3CB/PIK3R1/PLA2G4A/ASAP3/AKT3/VAV2/ACTR3C/PLCG2/PRKCE/DOCK1	2.88903565715056
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/404	70/9376	2.65233380480905	EPAS1/VEGFA/PIK3CB/PIK3R1/AKT3/TGFB2/TGFB1/EGLN3	2.94440110682795
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/404	86/9376	2.4287358968455	PIK3CB/EGFR/PIK3R1/AKT3/NRG2/CBLB/PTK2/CAMK2G/PLCG2	2.82439226467513
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/404	86/9376	2.4287358968455	ITGA5/TCF7L2/ITGB1/DSP/DES/PKP2/CACNB2/DSG2/DAG1	2.82439226467513
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	12/404	134/9376	2.07832126496232	ADM/PLA2G5/PLA2G4A/KCNMA1/ACTG2/PPP1R12B/MYH11/MYH9/MYH10/CALD1/PRKCE/PLA2G2A	2.66777547142255
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/404	59/9376	2.7534821278738	INSR/PIK3CB/PIK3R1/PTGS2/AKT3/IRS2/MGLL	2.86695575161788
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/404	59/9376	2.7534821278738	TCF7L2/PIK3CB/EGFR/PIK3R1/CDH1/AKT3/AXIN1	2.86695575161788
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/404	88/9376	2.37353735373537	SERPINE1/SERPINE2/SERPINC1/CD46/KNG1/F3/TFPI/SERPING1/CFH	2.74696038091374
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	10/404	105/9376	2.21027817067421	PIK3CB/PIK3R1/PTGS2/AKT3/CBLB/RRAS2/PLCG2/NFKBIA/NFATC4/KSR1	2.6463558804188
NA	NA	hsa03272	Virion - Hepatitis viruses	6/404	48/9376	2.9009900990099	EGFR/HSPG2/CLDN4/LDLR/CLDN19/TGOLN2	2.80180491757038
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/404	77/9376	2.41121254982641	PIK3CB/PIK3R1/CTBP2/AKT3/SMAD3/NFKBIA/TGFB2/TGFB1	2.63846511834348
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	13/404	157/9376	1.92167497004478	HLA-G/SERPINE1/FOXO1/PIK3CB/PIK3R1/AKT3/RRAS2/SMAD3/HIPK3/ZFP36L2/TGFB2/NFATC4/TGFB1	2.47125408672872
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/404	78/9376	2.38029956841838	ITGB1/PTGS2/JAK1/NFKBIA/TGFB2/FOS/JAK2/TGFB1	2.59751204978663
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	16/404	216/9376	1.71910524385772	TNFSF10/APOB/APOA1/PIK3CB/PIK3R1/AKT3/PTK2/CAMK2G/LDLR/VAV2/HSPA1B/ABCA1/NFKBIA/FOS/JAK2/HSP90B1	2.26883693088068
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	10/404	115/9376	2.01808006887645	PIK3CB/PIK3R1/CREB3L2/CREB5/AKT3/CAMK2G/KCNQ3/KCNJ2/FOS/JAK2	2.33095345570547
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/404	115/9376	2.01808006887645	GATA3/EGFR/GCM1/FGFR1/AKAP13/CREB3L2/CREB5/MMP15/MMP14/FOS	2.33095345570547
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	9/404	99/9376	2.10981098109811	IL1RAP/PIK3CB/PIK3R1/PLA2G4A/KNG1/IL1R1/CAMK2G/PLCG2/PRKCE	2.35556192028341
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	9/404	99/9376	2.10981098109811	TPM1/ITGA5/ITGB1/DES/PRKAG2/CACNB2/TGFB2/TGFB1/DAG1	2.35556192028341
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/404	69/9376	2.35442674702253	CREB3L2/CREB5/CAMK2G/MAOA/FOSB/MAOB/FOS	2.39611080898175
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/404	41/9376	2.83023424293649	GCSH/MAOA/GLDC/MAOB/PIPOX	2.49214399512311
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/404	70/9376	2.32079207920792	AKT3/PRKAG2/IRS2/CPT1B/NFKBIA/ACSL1/JAK2	2.35360533603488
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	16/404	224/9376	1.65770862800566	HLA-G/PIK3CB/PIK3R1/CREB3L2/CREB5/ETS2/AKT3/IL1R1/SMAD3/JAK1/NFKBIA/TGFB2/FOS/NFATC4/TGFB1/CRTC3	2.11412776966682
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/404	103/9376	2.02787657406517	SERPINE1/PIK3CB/PIK3R1/KNG1/AKT3/NFKBIA/TGFB2/FOS/TGFB1	2.22577437990541
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/404	42/9376	2.76284771334276	SAT1/TF/SLC39A14/CP/ACSL1	2.42961372273459
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	16/404	226/9376	1.6430386401472	PIK3CB/PIK3R1/CREB3L2/TIAM1/CREB5/AKT3/CRH/CAMK2G/RRAS2/VAV2/OXTR/AFDN/PDE10A/NFKBIA/FOS/VIPR2	2.07640674644576
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	16/404	227/9376	1.63580058446373	HLA-G/VEGFA/PIK3CB/EGFR/PIK3R1/AKAP13/CREB3L2/PTGS2/PTK2B/CREB5/AKT3/IL1R1/PTK2/JAK1/NFKBIA/NFATC4	2.05768421449909
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/404	43/9376	2.69859544093944	APOB/APOA1/PLA2G5/ABCA1/PLA2G2A	2.3688918690283
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/404	73/9376	2.22541706225417	PIK3CB/EGFR/PIK3R1/PDGFD/FGFR1/CDH1/AKT3	2.23031153677993
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	10/404	122/9376	1.90228858951469	FOXO1/INSR/PIK3CB/PIK3R1/CREB3L2/CREB5/AKT3/PRKAG2/IRS2/CPT1B	2.12859148886756
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	10/404	122/9376	1.90228858951469	PIK3CB/PIK3R1/CREB3L2/CREB5/AKT3/PTK2/IRS2/PLCG2/FOS/JAK2	2.12859148886756
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/404	44/9376	2.63726372637264	HEXB/MAN2A1/RPN1/MAN1A2/FUT8	2.30987937798263
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/404	90/9376	2.06292629262926	PIK3CB/EGFR/PIK3R1/AKT3/JAK1/NFKBIA/FOS/JAK2	2.15001630406713
Cellular Processes	Cell motility	hsa04814	Motor proteins	14/404	194/9376	1.67479840767582	TPM1/KIF21A/MYO1E/KIF2A/ACTG2/MYH11/TNNI2/KIFC2/MYO6/MYO5B/MYH9/KIF26B/MYH10/DNAH11	2.01529189448885
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/404	91/9376	2.04025677293004	PIK3CB/PIK3R1/AKT3/VAV2/CD22/PLCG2/NFKBIA/FOS	2.11593334424858
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	17/404	250/9376	1.57813861386139	HLA-G/EGFR/PARD3/ASAP3/RAB11FIP3/CBLB/LDLR/SMAD3/CLTB/ACTR3C/WIPF1/PRKCZ/CYTH3/HSPA1B/ARFGAP1/CBLC/ARF1	1.96604492430211
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/404	31/9376	2.99457042478441	GLUL/GCSH/GLDC/HYI	2.36032745164802
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	11/404	142/9376	1.79779668107656	PIK3CB/PIK3R1/AKT3/IL1R1/JAK1/PLCG2/FOSB/NFKBIA/TGFB2/FOS/TGFB1	2.0326993610212
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/404	125/9376	1.85663366336634	PIK3CB/PIK3R1/CERS6/KNG1/AKT3/SGMS2/SGPP1/PRKCZ/CERS5/PRKCE	2.04591455173907
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	12/404	160/9376	1.74059405940594	HLA-G/ITGB1/PTPRF/CDH1/CLDN4/NRXN3/NLGN1/F11R/CLDN19/CD22/JAM2/SDC4	2.00493672341815
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	14/404	196/9376	1.65770862800566	HLA-G/TCF7L2/VEGFA/PIK3CB/IL6ST/PIK3R1/PTGS2/AKT3/JAK1/PLCG2/NFKBIA/FOS/JAK2/NFATC4	1.97456721773268
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	8/404	94/9376	1.97514219507057	TNFAIP3/PTGS2/CEBPB/IL17RE/FOSB/NFKBIA/FOS/HSP90B1	2.01624257988489
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/404	20/9376	3.48118811881188	UGP2/CYB5R1/GMDS	2.35700917150908
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/404	63/9376	2.21027817067421	PLA2G5/PLA2G4A/PTGS2/GGT5/PTGIS/PLA2G2A	2.04523097601062
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/404	34/9376	2.73034362259755	PRKAG2/RORA/NPAS2/RORB	2.14478405343354
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/404	49/9376	2.36815518286523	CREB3L2/CREB5/MAOA/FOSB/MAOB	2.03748349768723
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	11/404	150/9376	1.70191419141914	TCF7L2/PIK3CB/EGFR/PIK3R1/CDH1/AKT3/SMAD3/TGFB2/AXIN1/WNT5A/TGFB1	1.83888519311025
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	14/404	205/9376	1.58493117604443	MT-ATP8/INSR/MT-ND4L/PIK3CB/PDK4/PIK3R1/AKT3/CAMK2G/SMAD3/CPT1B/PRKCZ/TGFB2/TGFB1/PDK3	1.79682193799984
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/404	99/9376	1.87538753875388	PIK3CB/EGFR/PIK3R1/PDGFD/PLA2G4A/AKT3/DGKI/FOS	1.85800067479866
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	12/404	170/9376	1.63820617355853	TCF7L2/PIK3CB/EGFR/PIK3R1/IGF2/AKT3/SMAD3/PLCG2/TGFB2/AXIN1/WNT5A/TGFB1	1.78189317599889
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/404	22/9376	3.16471647164716	AOC1/MAOA/MAOB	2.15697627228774
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/404	36/9376	2.57865786578658	UGP2/UGT2B7/CRPPA/DCXR	2.0137127433591
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	11/404	154/9376	1.65770862800566	EGFR/PLA2G4A/PTGS2/PRKAG2/PPP1R12B/CAMK2G/KCNJ2/OXTR/CACNB2/FOS/NFATC4	1.74627657726297
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/404	136/9376	1.70646476412347	TNFAIP3/PIK3CB/PIK3R1/CD46/AKT3/CBLB/JAK1/HSPA1B/NFKBIA/FOS	1.76098502392534
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/404	52/9376	2.23153084539223	INSR/PLA2G4A/PTGS2/LDLR/CYP11A1	1.88963324706012
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/404	37/9376	2.50896440995451	UGP2/HK2/GMDS/GALK1	1.95146766397194
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	13/404	193/9376	1.56322782537321	PIK3CB/PIK3R1/PARD3/CCL21/PTK2B/TIAM1/AKT3/PTK2/VAV2/PLCG2/PRKCZ/NFKBIA/JAK2	1.6776530584763
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/404	23/9376	3.02712010331468	CRPPA/LARGE1/B4GAT1	2.06537834758577
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/404	103/9376	1.8025569547246	COL4A2/COL4A1/MME/COL17A1/COL27A1/SLC38A2/COL12A1/COL7A1	1.73786498623682
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/404	69/9376	2.01808006887645	PIK3CB/PIK3R1/PLA2G4A/AKT3/VAV2/PLCG2	1.80108127870808
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	11/404	158/9376	1.61574132096754	INSR/PIK3CB/LPIN1/PIK3R1/GRB10/AKT3/CASTOR2/CLIP1/RPS6KA6/EIF4B/WNT5A	1.65630448913806
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/404	38/9376	2.44293903074518	HEXB/UGP2/HK2/GALK1	1.89123080338116
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/404	105/9376	1.76822253653937	TPM1/ITGA5/ITGB1/DES/CACNB2/TGFB2/TGFB1/DAG1	1.67977104462579
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	12/404	178/9376	1.56457892980309	TCF7L2/NOTUM/SFRP1/CTBP2/DKK1/CAMK2G/SMAD3/CTNND2/ANKRD6/AXIN1/NFATC4/WNT5A	1.61368831047596
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/404	71/9376	1.96123274299261	EGFR/F11R/TJP1/JAM2/PLCG2/NFKBIA	1.72516734878361
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	8/404	107/9376	1.73517164800592	FOXO1/CREB3L2/CREB5/AKT3/PRKAG2/CAMK2G/CPT1B/LDHA	1.62291541794915
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/404	12/9376	3.86798679867987	CD46/NECTIN4	2.10944767311387
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/404	56/9376	2.07213578500707	MGAT5/MAN2A1/RPN1/MAN1A2/FUT8	1.70752683424027
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/404	41/9376	2.26418739434919	VEGFA/THBS1/EGFR/CDH1	1.72138459090507
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/404	26/9376	2.67783701447068	PLA2G5/PLA2G4A/PLA2G2A	1.81786792926717
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/404	75/9376	1.85663366336634	ALB/GPX3/CREB3L2/CREB5/TTR/HSP90B1	1.58049321144595
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	19/404	323/9376	1.36517181129878	TIMP3/TPM1/ITGA5/EZR/VEGFA/PIK3CB/THBS1/EGFR/TNC/PIK3R1/PTGS2/IRS2/PLCG2/SLC7A1/CD44/TGFB2/PRKCE/GLS/EFNA4	1.41720910862835
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	13/404	205/9376	1.47172180632697	HLA-G/PIK3CB/IL6ST/PIK3R1/CREB3L2/CREB5/YWHAZ/ACTN1/JAK1/ACTN4/NFKBIA/CHD4/DDB1	1.44905952179378
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	10/404	148/9376	1.56810275622157	TCF7L2/PIK3CB/EGFR/NCOA1/PIK3R1/FGFR1/AKT3/AXIN1/FOS/WNT5A	1.47820834396615
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/404	76/9376	1.83220427305888	APOA2/APOC3/APOA1/SORBS1/CPT1B/ACSL1	1.54570620937301
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/404	76/9376	1.83220427305888	PIK3CB/EGFR/PIK3R1/AKT3/CAMK2G/PLCG2	1.54570620937301
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/404	116/9376	1.6005462615227	HOMER1/SHANK2/PLA2G4A/GLUL/SLC38A2/SLC1A3/SLC38A1/GLS	1.38102537168274
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/404	45/9376	2.06292629262926	ABCA8/ABCA6/DEFB1/ABCA1	1.51662077378004
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/404	98/9376	1.65770862800566	CREB3L2/DAGLB/CREB5/CAMK2G/LDLR/CYP11A1/PRKCE	1.38883637040689
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	10/404	155/9376	1.49728521239221	TCF7L2/EGFR/CREB3L2/CREB5/CRH/CAMK2G/LDLR/CYP11A1/AXIN1/WNT5A	1.32468943101514
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	13/404	214/9376	1.40982696400481	HLA-G/PIK3CB/PIK3R1/PTK2B/AKT3/PTK2/WEE1/PLCG2/BST2/NFKBIA/FOS/NFATC4/DDB1	1.28689750852536
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/404	63/9376	1.84189847556184	PLOD2/KMT2C/AASS/PIPOX/PLOD1	1.42271163985053
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/404	15/9376	3.09438943894389	HEXB/ST6GALNAC5	1.7225571296909
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	10/404	156/9376	1.48768723026149	PIK3CB/EGFR/PIK3R1/CLDN4/AKT3/YWHAZ/LDLR/CLDN19/JAK1/NFKBIA	1.3033765739557
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/404	30/9376	2.32079207920792	PLA2G5/PLA2G4A/PLA2G2A	1.53749560540455
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	13/404	217/9376	1.39033626864991	VEGFA/PIK3CB/EGFR/PIK3R1/CREB3L2/CREB5/AKT3/UGT2B7/KLF5/RPS6KA6/FOS/JAK2/HSP90B1	1.23445832248986
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/404	16/9376	2.9009900990099	MAOA/MAOB	1.6148552887172
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/404	48/9376	1.93399339933993	PIK3CB/PIK3R1/AKT3/HK2	1.37658123554239
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/404	66/9376	1.75817581758176	GATA3/SMAD3/RORA/TGFB2/TGFB1	1.31159195407952
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	8/404	122/9376	1.52183087161175	FOXO1/PIK3CB/NCOA1/PIK3R1/THRB/MED13L/AKT3/PLCG2	1.23105264196963
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/404	32/9376	2.17574257425743	UGP2/HK2/GALK1	1.41368453509486
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	9/404	142/9376	1.47092455724446	UBE2K/CBLB/HERC1/BIRC7/MID1/UBR5/CBLC/PRPF19/DDB1	1.19986466389942
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/404	49/9376	1.89452414629218	GALNT15/GALNT2/GALNT6/GALNT17	1.33214288055847
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/404	104/9376	1.56207159177456	PLA2G5/LPIN1/PLA2G4A/LPCAT1/DGKI/SGMS2/PLA2G2A	1.22307554365944
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/404	17/9376	2.73034362259755	GGT5/BAAT	1.51521332873477
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/404	17/9376	2.73034362259755	GLUL/CA12	1.51521332873477
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/404	50/9376	1.85663366336634	THBS1/THBS3/TGFB2/TGFB1	1.28873647915589
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/404	68/9376	1.70646476412347	TCF7L2/ZBTB16/PIK3CB/PIK3R1/AKT3	1.24064766656222
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/404	51/9376	1.8202290817317	PLA2G5/PLA2G4A/LPCAT1/PLA2G2A	1.24631413195244
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/404	51/9376	1.8202290817317	TJP2/TJP1/PLCG2/ARF1	1.24631413195244
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	14/404	248/9376	1.31012456084318	TCF7L2/TNFSF10/ANXA2/PIK3CB/AHNAK/AKT3/RHOB/MYO6/ACTR3C/CYTH3/NFKBIA/FOS/HSP90B1/ARF1	1.05028188585235
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/404	89/9376	1.56457892980309	GLUL/SLC38A2/SLC38A1/GABARAPL1/GLS/GPHN	1.13556927934422
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/404	35/9376	1.98925035360679	ALDOB/HK2/GMDS	1.24415714678482
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/404	71/9376	1.63436061916051	PIK3CB/PIK3R1/AKT3/FOS/JAK2	1.13851534449683
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/404	19/9376	2.44293903074518	GCSH/GLDC	1.33594369623319
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/404	73/9376	1.58958361589584	PIK3CB/EGFR/PIK3R1/AKT3/PLCG2	1.0730674322504
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/404	37/9376	1.88172330746588	MAOA/PNMT/MAOB	1.14028834062556
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/404	38/9376	1.83220427305888	INSR/PIK3CB/PIK3R1	1.09075319357158
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/404	95/9376	1.46576341844711	FLT1/VEGFA/CTSL/TGFB2/FOS/TGFB1	0.96819197854522
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/404	39/9376	1.78522467631379	GCSH/GLDC/MTHFD1L	1.04268770278512
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	8/404	137/9376	1.35520705355207	TNFSF10/CTSL/PIK3CB/PIK3R1/AKT3/DAB2IP/NFKBIA/FOS	0.888712051571883
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/404	98/9376	1.42089310971914	PIK3CB/PIK3R1/DGKI/INPP5B/PLCG2/SYNJ2	0.888769941492336
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/404	99/9376	1.40654065406541	PIK3CB/EGFR/PIK3R1/AKT3/PTK2/FOS	0.862878183829148
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/404	120/9376	1.35379537953795	PIK3CB/PIK3R1/AKT3/CAMK2G/PLCG2/NFKBIA/RPS6KA6	0.827680636807605
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/404	23/9376	2.01808006887645	GLUL/GLS	1.03729449820351
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/404	61/9376	1.52183087161175	TF/MT1X/STEAP2/SLC39A4	0.867630768101387
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/404	42/9376	1.65770862800566	AOC1/MAOA/MAOB	0.906475299067865
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/404	122/9376	1.33160201266028	PIK3CB/PIK3R1/AKT3/CBLB/VAV2/NFKBIA/FOS	0.782283218520673
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	9/404	166/9376	1.25826076583562	INSR/CREB3L2/CREB5/KNG1/AKT3/KCNMA1/IRS2/PRKCE/NFATC4	0.712384319891502
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/404	63/9376	1.47351878044947	TCF7L2/BMP2/AXIN1/WNT5A	0.80019230369043
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/404	105/9376	1.32616690240453	TNFAIP3/CCL21/PTGS2/IL1R1/PLCG2/NFKBIA	0.713186208832773
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/404	168/9376	1.24328147100424	PIK3CB/EGFR/IL6ST/PIK3R1/AKT3/JAK1/LIFR/IL13RA1/JAK2	0.675169331558124
Organismal Systems	Immune system	hsa04611	Platelet activation	7/404	126/9376	1.28932893289329	ITGB1/PIK3CB/PIK3R1/PLA2G4A/AKT3/PLCG2/PRKCZ	0.693805853788126
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	15/404	298/9376	1.16818393248721	IL1RL1/TNFSF10/IL1RAP/INHBA/IL6ST/CCL21/BMP2/INHA/EBI3/IL1R1/IL17RE/LIFR/TGFB2/IL13RA1/TGFB1	0.626079140144052
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/404	65/9376	1.42817974105103	CREB3L2/CREB5/LDLR/CYP11A1	0.735049046365259
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/404	65/9376	1.42817974105103	PIK3CB/PIK3R1/AKT3/KCNN2	0.735049046365259
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/404	26/9376	1.78522467631379	APOB/APOA1	0.850758890183591
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/404	86/9376	1.34929772046972	CREB3L2/CREB5/KCNMA1/CAMK2G/KCNN2	0.690508149155871
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/404	67/9376	1.38554750997488	ALDOB/HK2/LDHA/ENO1	0.67204054774139
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	6/404	109/9376	1.27750022708693	PIK3CB/PIK3R1/AKT3/JAK1/NFKBIA/FOS	0.618356170069564
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/404	68/9376	1.36517181129878	UGT2B7/CYP26A1/ALDH1A2/CYP3A5	0.64129108568385
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/404	133/9376	1.22146951537259	HLA-G/TNFSF10/PIK3CB/PIK3R1/PTK2B/VAV2/PLCG2	0.54583953409847
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	7/404	133/9376	1.22146951537259	CREB3L2/CREB5/AKT3/CAMK2G/MAOA/MAOB/FOS	0.54583953409847
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/404	29/9376	1.6005462615227	TEAD1/WWTR1	0.687291596259826
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	8/404	157/9376	1.18256921233525	INSR/PIK3CB/PIK3R1/AKT3/PRKAG2/IRS2/FOS/TGFB1	0.489516290186771
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	10/404	201/9376	1.15462292497907	FLT1/AFF1/ZBTB16/FOXO1/CEBPB/ASPSCR1/PTK2/WT1/FUT8/SPINT1	0.470219423876892
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	9/404	180/9376	1.16039603960396	HLA-G/ITGA5/PIK3CB/PIK3R1/AKT3/JAK1/BST2/NFKBIA/JAK2	0.461064941248531
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/404	93/9376	1.24773767699351	GATA3/JAK1/NFKBIA/FOS/JAK2	0.509472853586821
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/404	93/9376	1.24773767699351	EGFR/PLA2G4A/PTK2B/CAMK2G/MMP14	0.509472853586821
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/404	115/9376	1.21084804132587	PLA2G4A/PTGS2/DUSP1/MAOA/MAOB/KCNN2	0.482748838310588
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/404	73/9376	1.27166689271667	UGT2B7/CYP3A5/MAOA/MAOB	0.494445379985634
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/404	73/9376	1.27166689271667	ELL2/BST2/ELL/NELFE	0.494445379985634
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	7/404	140/9376	1.16039603960396	SERPINE1/CDH1/AKT3/PRKAG2/RRAS2/SMAD3/PRKCE	0.405739588844928
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	4/404	75/9376	1.23775577557756	SERPINE1/THBS1/PERP/SESN1	0.438660544585321
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/404	76/9376	1.22146951537259	EZR/CAMK2G/KCNJ15/KCNJ2	0.41134949216251
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	7/404	144/9376	1.12816281628163	TCF7L2/FOXO1/LPIN1/AKT3/PRKAG2/CPT1B/NFKBIA	0.328872135657194
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/404	100/9376	1.16039603960396	ITGA5/MME/IL1R1/CD22/CD44	0.34217238670592
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	11/404	235/9376	1.08632820728881	MT-ATP8/MT-ND4L/FGFR1/CREB3L2/CREB5/PRKAG2/CPT1B/CNR1/RPS6KA6/ACSL1/MGLL	0.284394692614131
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/404	78/9376	1.19014978420919	PIK3CB/INPP5B/PLCG2/SYNJ2	0.357832724901635
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/404	78/9376	1.19014978420919	ITGA5/ITGB1/SERPING1/FOS	0.357832724901635
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/404	56/9376	1.24328147100424	HSPA1B/NFKBIA/ARF1	0.38745991489357
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/404	14/9376	1.65770862800566	FUT8	0.522570545026629
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/404	36/9376	1.28932893289329	UGP2/HK2	0.369063729270692
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/404	59/9376	1.18006376908877	GPX3/GGT5/PRDX6	0.294405543256386
NA	NA	hsa04081	Hormone signaling	10/404	219/9376	1.05972241059722	INSR/PIK3CB/PIK3R1/THRB/IGF2/CRH/IRS2/OXTR/JAK2/VIPR2	0.189764280269435
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	8/404	174/9376	1.06703084101514	RRBP1/P4HB/RPN1/HSPA1B/ERP29/SELENOS/MAN1A2/HSP90B1	0.189382509190251
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/404	37/9376	1.25448220497725	GLUL/GLS	0.329109017279183
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/404	37/9376	1.25448220497725	APOA1/KNG1	0.329109017279183
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/404	37/9376	1.25448220497725	TCF7L2/CDH1	0.329109017279183
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/404	16/9376	1.45049504950495	HEXB	0.382687060607462
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	10/404	227/9376	1.02237536528983	MT-ATP8/MT-ND4L/VEGFA/PIK3CB/EGFR/PIK3R1/AKT3/PTK2/NFKBIA/FOS	0.0724149003250348
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/404	181/9376	1.02576445489853	CEBPB/AKT3/CAMK2G/JAK1/TGFB2/JAK2/TGFB1/KSR1	0.0742704520757211
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	9/404	205/9376	1.01888432745714	HLA-G/TNFAIP3/PIK3CB/PIK3R1/AKT3/JAK1/PLCG2/NFKBIA/CD44	0.0580098569695266
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/404	17/9376	1.36517181129878	BAAT	0.319770702496366
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/404	65/9376	1.07113480578827	LPIN1/DGKI/MGLL	0.122115939043962
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	11/404	254/9376	1.00506743587745	FLT1/VEGFA/EGFR/PDGFD/FGFR1/PTK2B/CAMK2G/CASQ1/OXTR/PLCG2/NFATC4	0.0173736782572347
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/404	89/9376	1.04305261986873	EGFR/PDGFD/LPAR1/TJP1	0.0865941499716675
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/404	66/9376	1.05490549054905	UGT2B7/CYP11A1/CYP3A5	0.0949827176875946
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/404	90/9376	1.03146314631463	UGT2B7/LDLR/BAAT/KCNN2	0.0636415507103292
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/404	18/9376	1.28932893289329	ACSL1	0.260716360965496
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/404	18/9376	1.28932893289329	HEXB	0.260716360965496
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/404	43/9376	1.07943817637578	CPT1B/ACSL1	0.11078591498099
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	5/404	116/9376	1.00034141345169	ALDOB/HK2/GCSH/GLDC/ENO1	0.00078511959731828
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/404	19/9376	1.22146951537259	HEXB	0.205047335102602
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/404	44/9376	1.05490549054905	CREB3L2/CREB5	0.0774615954133813
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/404	70/9376	0.994625176803395	PTGS2/UGT2B7/CYP3A5	-0.0095777471374304
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	7/404	168/9376	0.966996699669967	TNFSF10/TNFAIP3/PLA2G4A/GLUL/CAMK2G/JAK1/JAK2	-0.0915927387772647
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/404	46/9376	1.00904003443823	UGT2B7/CP	0.0130418700093101
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/404	169/9376	0.961274825707423	CTSL/PIK3CB/PIK3R1/AKT3/RRAS2/IRS2/GABARAPL1	-0.10779766410625
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/404	21/9376	1.10513908533711	CHST11	0.102349007195253
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	7/404	173/9376	0.939048818176615	TNFSF10/PIK3CB/PIK3R1/AKT3/JAK1/NFKBIA/JAK2	-0.171700737159902
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/404	75/9376	0.928316831683168	ALDOB/GLUL/ENO1	-0.132255788844991
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/404	75/9376	0.928316831683168	PIK3CB/PIK3R1/AKT3	-0.132255788844991
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/404	23/9376	1.00904003443823	MME	0.00921064882125745
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/404	23/9376	1.00904003443823	GLS	0.00921064882125745
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/404	101/9376	0.919125575923929	TCF7L2/CREB3L2/CAMK2G/WNT5A	-0.173399011371475
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	6/404	154/9376	0.904204706184904	TPM1/CREB3L2/CREB5/AKT3/CAMK2G/CACNB2	-0.254345268829113
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/404	78/9376	0.892612338156893	ZCCHC7/BTG1/ENO1	-0.202087106319615
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	6/404	155/9376	0.898371127435324	HLA-G/ITGA5/ITGB1/CTSL/THBS1/THBS3	-0.27072329926077
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/404	158/9376	0.881313447800476	YWHAZ/SMAD3/WEE1/TGFB2/SMC3/TGFB1	-0.319259179974301
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/404	54/9376	0.85955262192886	LDHA/AMD1	-0.219627973787779
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/404	82/9376	0.849070272880947	HLA-G/CTSL/HSPA1B	-0.29128093987332
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/404	27/9376	0.85955262192886	BAAT	-0.155076012905809
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/404	83/9376	0.83884051055708	BAAT/PIPOX/ACSL1	-0.312931043826054
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	9/404	238/9376	0.877610450120642	PIK3CB/EGFR/IL6ST/PIK3R1/RPS4Y1/JAK1/PLCG2/NFKBIA/FOS	-0.405825121661417
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/404	110/9376	0.843924392439244	PIK3CB/PIK3R1/AKT3/RPS6KA6	-0.349395186166533
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	15/404	388/9376	0.897213432683475	MT-ATP8/MME/INSR/MT-ND4L/PIK3CB/PIK3R1/PTGS2/SLC39A14/AKT3/DKK1/IRS2/RTN4/AXIN1/WNT5A/SLC39A4	-0.438785615359839
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/404	28/9376	0.828854314002829	GPHN	-0.192449731107241
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/404	57/9376	0.814313010248393	CPT1B/ACSL1	-0.298377407381759
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/404	85/9376	0.819103086779266	GDA/ADK/UCK2	-0.355501205168474
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/404	60/9376	0.773597359735974	PLA2G4A/CRH	-0.373313814025298
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/404	31/9376	0.748642606196103	ALDOB	-0.29745039302594
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/404	31/9376	0.748642606196103	UGT2B7	-0.29745039302594
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/404	31/9376	0.748642606196103	IMMP2L	-0.29745039302594
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/404	117/9376	0.793433189472794	MORF4L2/MBD2/CHD4/MBD3	-0.477093083993597
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/404	144/9376	0.805830583058306	PIK3CB/PIK3R1/AKT3/KCNC3/RORA	-0.498248342862616
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/404	32/9376	0.725247524752475	LDHA	-0.330355754516904
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/404	32/9376	0.725247524752475	GABARAPL1	-0.330355754516904
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/404	32/9376	0.725247524752475	BIRC7	-0.330355754516904
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/404	149/9376	0.778789288324806	MT-ND4L/PTGS2/DAGLB/CNR1/MGLL	-0.577564797482044
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/404	67/9376	0.692773754987439	CAMK2G/RPS6KA6	-0.535520237161499
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/404	69/9376	0.672693356292151	KCNMA1/KCNJ2	-0.579036842386627
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/404	99/9376	0.703270327032703	KRT19/DEFB1/CFH	-0.629805552625113
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/404	70/9376	0.663083451202263	HLA-G/DAG1	-0.600373517930507
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/404	100/9376	0.696237623762376	TNFSF10/IL6ST/CCL21	-0.648015359514668
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/404	38/9376	0.610734757686295	NNMT	-0.510202026047573
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/404	39/9376	0.595074892104595	HLA-G	-0.537693787889512
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/404	102/9376	0.682585905649388	PLA2G5/KCNMA1/PLA2G2A	-0.683950128554376
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/404	105/9376	0.663083451202263	CITED2/RRAS2/GABARAPL1	-0.73669104485675
Human Diseases	Substance dependence	hsa05034	Alcoholism	6/404	191/9376	0.729044632211912	CREB3L2/CREB5/CRH/MAOA/FOSB/MAOB	-0.802798496889681
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/404	138/9376	0.672693356292151	YWHAZ/CAMK2G/RPS6KA6/SMC3	-0.82193424134399
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/404	44/9376	0.527452745274527	TAF4B	-0.666677665443035
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/404	44/9376	0.527452745274527	HLA-G	-0.666677665443035
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/404	79/9376	0.587542298533651	UGT2B7/CYP3A5	-0.78118381307881
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/404	79/9376	0.587542298533651	SLC1A3/CLTB	-0.78118381307881
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	10/404	308/9376	0.753503921820753	MT-ATP8/GPX3/MT-ND4L/TAF4B/CREB3L2/CREB5/SLC1A3/CLTB/RCOR1/DNAH11	-0.933386047706447
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/404	45/9376	0.515731573157316	HLA-G	-0.690971294367598
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/404	82/9376	0.566046848587298	UGT2B7/UCK2	-0.83749095832377
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/404	47/9376	0.493785548767643	LDHA	-0.738240062851009
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/404	50/9376	0.464158415841584	TGFB1	-0.806130585435932
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/404	87/9376	0.533515420507568	TPM1/CACNB2	-0.927564513321075
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	8/404	268/9376	0.692773754987439	MT-ATP8/MT-ND4L/SLC39A14/DUSP1/CAMK2G/MAOA/MAOB/SLC39A4	-1.08279411620122
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/404	53/9376	0.437885297963759	CLTB	-0.870796601331665
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/404	154/9376	0.602803137456603	UGP2/UGT2B7/MTHFD1L/GPHN	-1.05459400726595
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/404	54/9376	0.42977631096443	HLA-G	-0.891701042402078
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/404	56/9376	0.414427157001414	HHAT	-0.932607004453127
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/404	128/9376	0.543935643564356	GDA/ADK/PDE10A	-1.10239921169014
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/404	97/9376	0.47851383076452	CAMK2G/FOS	-1.0954933931555
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/404	59/9376	0.393354589696258	UCK2	-0.991869560924358
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/404	62/9376	0.374321303098052	CTBP2	-1.04884372588899
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/404	63/9376	0.368379695112368	DDB1	-1.06736570478986
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	7/404	275/9376	0.590747074707471	MT-ATP8/MT-ND4L/PIK3CB/PIK3R1/CREB3L2/CREB5/HSPA1B	-1.46165632562686
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/404	72/9376	0.322332233223322	NFKBIA	-1.22484156182312
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	4/404	187/9376	0.496426113199555	TNFAIP3/JAK1/NFKBIA/GABARAPL1	-1.47598371961044
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/404	195/9376	0.476059913683676	PIK3CB/PIK3R1/AKT3/PLCG2	-1.56886519221187
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/404	83/9376	0.279613503519027	L3MBTL1	-1.39880871477834
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/404	83/9376	0.279613503519027	NFKBIA	-1.39880871477834
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/404	91/9376	0.255032096616255	PDE10A	-1.51530128732037
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/404	93/9376	0.249547535398701	KCNMA1	-1.54330646537752
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	2/404	138/9376	0.336346678146075	MT-ATP8/MT-ND4L	-1.6665698668198
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	5/404	250/9376	0.464158415841584	HEXB/CTSL/AP3S1/CLTB/PSAP	-1.82220768775226
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/404	143/9376	0.324586304784325	ACTN1/ACTN4	-1.72702312056582
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/404	183/9376	0.380457717902938	SBDS/RMRP/REXO2	-1.79597196990183
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/404	103/9376	0.225319619340575	MSI2	-1.67750076944335
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/404	370/9376	0.501792881990902	ADM/THRB/KNG1/CRH/LPAR1/CNR1/OXTR/VIPR2	-2.07480127946732
Genetic Information Processing	Transcription	hsa03040	Spliceosome	4/404	243/9376	0.382023387523938	HSPA1B/PRPF19/RBM25/SLU7	-2.07109555060657
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	9/404	480/9376	0.435148514851485	MT-ATP8/GPX3/MT-ND4L/PTGS2/DKK1/CAMK2G/AXIN1/WNT5A/DNAH11	-2.69580947152234
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	5/404	368/9376	0.315325010761946	MT-ATP8/GPX3/MT-ND4L/NRG2/DNAH11	-2.84332086835187
NA	NA	hsa04082	Neuroactive ligand signaling	1/404	199/9376	0.116622717548137	SLC1A3	-2.67272383773435
Genetic Information Processing	Translation	hsa03010	Ribosome	1/404	222/9376	0.104540183748105	RPS4Y1	-2.86515962872521
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/404	449/9376	0.0516880195814682	CAMK2G	-4.36971717469363