category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	135/1442	268/9376	3.2753017161074	RPS27A/MT-CO2/UCHL1/NDUFA13/COX4I1/NDUFA4/COX5B/UQCR10/NDUFC2/UQCRH/UBA52/COX7A2/MT-CO1/UBB/PSMA7/SLC25A6/COX6A1/NDUFS5/UQCRB/TUBA1B/COX6B1/ATP5MC2/ATP5F1E/TXN/COX8A/NDUFA11/UQCR11/COX6C/CALM2/ATP5MC3/ATP5F1D/PARK7/GNAS/NDUFB2/PSMB1/UQCRQ/ATP5PF/MT-CYB/NDUFS6/GNAI2/TUBA4A/TUBB/ATP5F1B/SLC25A5/COX7B/COX7C/ATP5F1A/NDUFB10/PSMB5/PSMD2/NDUFB11/PSMB3/NDUFB7/NDUFV2/HSPA5/PSMD8/CALM1/NDUFA1/PSMA2/NDUFB9/NDUFS8/PSMB6/PSMA1/NDUFB4/NDUFB8/COX5A/PSMA6/ATP5F1C/BAX/ADRM1/UQCRC1/NDUFAB1/VDAC2/PSMA4/SOD1/SLC39A8/ATP5PD/ATP5PO/ITPR2/PSMC5/NDUFA2/VDAC1/ATP5MC1/NDUFB3/NDUFB5/UQCRFS1/MT-CO3/PSMB2/CYCS/PSMA5/PSMB7/TUBB3/CYC1/PSMA3/SEM1/COX7A2L/SLC39A13/UBE2L3/CALM3/PSMD3/NDUFA6/ATP5PB/NDUFA8/NDUFS7/PSMB4/PSMC2/TUBA1C/NDUFA7/NDUFA12/MT-ATP6/PSMD4/SLC39A7/NDUFC1/NDUFS2/KIF5B/PSMC3/NDUFB6/COX4I2/PSMC6/PSMD7/CALML4/UBE2J2/PSMD1/SLC25A4/ITPR3/PSMD9/SDHC/KEAP1/PSMD6/SDHD/PSMC4/KLC2/ITPR1/NDUFS3/PSMC1	16.1107979376449
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	137/1442	275/9376	3.23921825747068	CYBA/MT-CO2/NDUFA13/COX4I1/NDUFA4/COX5B/UQCR10/PRNP/NDUFC2/UQCRH/COX7A2/MT-CO1/PSMA7/SLC25A6/COX6A1/NDUFS5/UQCRB/TUBA1B/COX6B1/ATP5MC2/ATP5F1E/COX8A/NDUFA11/UQCR11/COX6C/IL6/ATP5MC3/ATP5F1D/NDUFB2/CYBB/PSMB1/UQCRQ/ATP5PF/MT-CYB/NDUFS6/RYR2/TUBA4A/TUBB/RAC2/ATP5F1B/SLC25A5/COX7B/COX7C/ATP5F1A/NDUFB10/PSMB5/PSMD2/NDUFB11/PSMB3/NDUFB7/NDUFV2/HSPA5/RAC1/C1QA/PSMD8/NDUFA1/PSMA2/NDUFB9/NDUFS8/PSMB6/HSPA8/PSMA1/IL1A/NDUFB4/NDUFB8/COX5A/PSMA6/ATP5F1C/C1QC/CSNK2B/BAX/ADRM1/UQCRC1/NDUFAB1/VDAC2/PSMA4/NCF4/SOD1/ATP5PD/ATP5PO/ITPR2/PSMC5/NDUFA2/VDAC1/ATP5MC1/NDUFB3/NDUFB5/UQCRFS1/MT-CO3/PSMB2/CYCS/PSMA5/PSMB7/IL1B/TUBB3/CYC1/PSMA3/SEM1/COX7A2L/PSMD3/NDUFA6/ATP5PB/NDUFA8/C6/NDUFS7/PSMB4/PSMC2/TUBA1C/NDUFA7/NDUFA12/MT-ATP6/PSMD4/NDUFC1/NDUFS2/KIF5B/PSMC3/NDUFB6/GRIN2C/COX4I2/PSMC6/PSMD7/MAPK13/PSMD1/SLC25A4/ITPR3/PSMD9/SDHC/PSMD6/PPP3R1/SDHD/PSMC4/PIK3CD/KLC2/ITPR1/NDUFS3/PSMC1/CSNK2A1	16.0672069128401
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	146/1442	308/9376	3.08215501558081	PLCB1/MT-CO2/AP2S1/NDUFA13/COX4I1/CLTA/NDUFA4/COX5B/UQCR10/NDUFC2/UQCRH/COX7A2/MT-CO1/PSMA7/SLC25A6/AP2M1/COX6A1/NDUFS5/UQCRB/TUBA1B/COX6B1/ATP5MC2/ATP5F1E/COX8A/NDUFA11/UQCR11/COX6C/CLTC/ATP5MC3/ATP5F1D/POLR2L/NDUFB2/PSMB1/UQCRQ/ATP5PF/MT-CYB/NDUFS6/TUBA4A/TUBB/ATP5F1B/SLC25A5/COX7B/COX7C/ATP5F1A/NDUFB10/PSMB5/PSMD2/NDUFB11/PSMB3/NDUFB7/NDUFV2/GRIA4/PSMD8/NDUFA1/PSMA2/NDUFB9/NDUFS8/PSMB6/PSMA1/NDUFB4/NDUFB8/COX5A/PSMA6/ATP5F1C/BAX/ADRM1/UQCRC1/NDUFAB1/VDAC2/PSMA4/SOD1/ATP5PD/ATP5PO/GPX7/BDNF/PSMC5/NDUFA2/POLR2K/VDAC1/ATP5MC1/NDUFB3/POLR2J/GRIA3/NDUFB5/DNAH8/UQCRFS1/MT-CO3/PSMB2/CYCS/PSMA5/PSMB7/POLR2E/TUBB3/WIPI2/CYC1/PSMA3/SEM1/COX7A2L/PSMD3/NDUFA6/DNAH14/DCTN3/ATP5PB/NDUFA8/NDUFS7/PSMB4/PSMC2/TUBA1C/POLR2G/NDUFA7/NDUFA12/MT-ATP6/PSMD4/NDUFC1/NDUFS2/KIF5B/HDAC2/PSMC3/NDUFB6/COX4I2/PSMC6/POLR2I/PSMD7/POLR2F/GPX8/PSMD1/SLC25A4/DCTN4/DCTN6/PSMD9/SDHC/POLR2B/PSMD6/SDHD/TBPL1/PSMC4/HDAC1/POLR2A/ACTR10/KLC2/ITPR1/PLCB2/NDUFS3/TFAM/DNALI1/PSMC1	15.8399874173841
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	84/1442	138/9376	3.95778809624314	MT-CO2/NDUFA13/COX4I1/NDUFA4/COX5B/ATP6V1G1/UQCR10/ATP6V0B/NDUFC2/UQCRH/ATP6V1F/COX7A2/MT-CO1/ATP5MG/COX6A1/NDUFS5/UQCRB/COX6B1/ATP5MC2/ATP5F1E/COX8A/NDUFA11/ATP6V0E1/UQCR11/COX6C/ATP5MF/ATP5MC3/ATP5F1D/NDUFB2/ATP6V0C/UQCRQ/ATP5PF/MT-CYB/NDUFS6/ATP5F1B/COX7B/COX7C/ATP5F1A/NDUFB10/NDUFB11/NDUFB7/NDUFV2/NDUFA1/NDUFB9/NDUFS8/NDUFB4/NDUFB8/COX5A/ATP6AP1/ATP5F1C/UQCRC1/NDUFAB1/ATP6V1A/ATP5PD/ATP5PO/NDUFA2/ATP5MC1/ATP6V0D1/NDUFB3/NDUFB5/UQCRFS1/MT-CO3/CYCS/COX17/CYC1/COX7A2L/NDUFA6/ATP5ME/ATP5PB/NDUFA8/ATP6V1D/NDUFS7/ATP6V1E1/NDUFA7/NDUFA12/MT-ATP6/NDUFC1/NDUFS2/NDUFB6/COX4I2/SDHC/ATP6V1B2/SDHD/NDUFS3	14.92243828125
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	155/1442	388/9376	2.59748058967356	PLCB1/MT-CO2/GAPDH/NDUFA13/COX4I1/NDUFA4/COX5B/UQCR10/NDUFC2/UQCRH/COX7A2/MT-CO1/PSMA7/SLC25A6/COX6A1/NDUFS5/UQCRB/TUBA1B/COX6B1/ATP5MC2/ATP5F1E/COX8A/NDUFA11/UQCR11/COX6C/IL6/CALM2/ATP5MC3/ATP5F1D/NDUFB2/CYBB/PSMB1/WNT2/UQCRQ/ATP5PF/MT-CYB/NDUFS6/TUBA4A/TUBB/ATP5F1B/SLC25A5/COX7B/COX7C/ATP5F1A/NDUFB10/PSMB5/PSMD2/NDUFB11/PSMB3/NDUFB7/NDUFV2/PSMD8/MAP2K2/CALM1/NDUFA1/PSMA2/NDUFB9/NDUFS8/PSMB6/PSMA1/IL1A/NDUFB4/NDUFB8/COX5A/PSMA6/TNFRSF1A/ATP5F1C/CSNK2B/ADRM1/UQCRC1/NDUFAB1/VDAC2/PSMA4/SLC39A8/ATP5PD/BID/ATP5PO/ITPR2/PSMC5/NDUFA2/VDAC1/FZD4/ATP5MC1/LRP1/NDUFB3/NDUFB5/UQCRFS1/MT-CO3/PSMB2/CYCS/FZD2/PSMA5/PSMB7/IL1B/TUBB3/WIPI2/CYC1/PSMA3/SEM1/COX7A2L/SLC39A13/CALM3/PSMD3/NDUFA6/ATP5PB/NDUFA8/FZD7/NDUFS7/PSMB4/PSMC2/TUBA1C/NDUFA7/NDUFA12/MT-ATP6/APOE/HRAS/PSMD4/ADAM10/SLC39A7/NDUFC1/NDUFS2/KIF5B/APH1A/HSD17B10/PSMC3/NDUFB6/GRIN2C/COX4I2/PSMC6/PSMD7/APP/CALML4/PSMD1/SLC25A4/ITPR3/PSMD9/SDHC/PSMD6/PPP3R1/SDHD/NCSTN/PSMC4/PIK3CD/KLC2/AKT1/ITPR1/PLCB2/CAPN1/NDUFS3/ATP2A2/CDK5/PSMC1/CSNK2A1/DVL3/WNT10A	13.7006790009669
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	175/1442	480/9376	2.3705501618123	PLCB1/RPS27A/MT-CO2/UCHL1/NDUFA13/COX4I1/NDUFA4/COX5B/UQCR10/PRNP/NDUFC2/UQCRH/UBA52/COX7A2/MT-CO1/UBB/PSMA7/SLC25A6/COX6A1/NDUFS5/UQCRB/SQSTM1/TUBA1B/COX6B1/ATP5MC2/ATP5F1E/COX8A/NDUFA11/UQCR11/COX6C/IL6/CALM2/ATP5MC3/ATP5F1D/PARK7/NDUFB2/CYBB/PSMB1/WNT2/UQCRQ/ATP5PF/MT-CYB/NDUFS6/RYR2/TUBA4A/TUBB/ATP5F1B/SLC25A5/COX7B/COX7C/ATP5F1A/NDUFB10/PSMB5/PSMD2/NDUFB11/PSMB3/NDUFB7/NDUFV2/HSPA5/RAC1/GRIA4/PSMD8/MAP2K2/CALM1/NDUFA1/PSMA2/NDUFB9/NDUFS8/PSMB6/PSMA1/IL1A/NDUFB4/NDUFB8/COX5A/PSMA6/TNFRSF1A/ATP5F1C/CSNK2B/BAX/ADRM1/UQCRC1/NDUFAB1/VDAC2/PSMA4/SOD1/VCP/ATP5PD/BID/ATP5PO/GPX7/ITPR2/BDNF/PSMC5/NDUFA2/VDAC1/FZD4/ATP5MC1/NDUFB3/GRIA3/NDUFB5/DNAH8/UQCRFS1/MT-CO3/PSMB2/CYCS/FZD2/PSMA5/PSMB7/IL1B/TUBB3/PRKCB/WIPI2/CYC1/PSMA3/SEM1/COX7A2L/UBE2L3/CALM3/PSMD3/NDUFA6/DNAH14/DCTN3/ATP5PB/NDUFA8/FZD7/NDUFS7/PSMB4/PSMC2/TUBA1C/NDUFA7/NDUFA12/MT-ATP6/HRAS/PSMD4/NDUFC1/NDUFS2/KIF5B/HSD17B10/PSMC3/NDUFB6/GRIN2C/COX4I2/PSMC6/PSMD7/APP/MAPK13/GPX8/CALML4/UBE2J2/PSMD1/SLC25A4/ITPR3/DCTN4/DCTN6/PSMD9/SDHC/SIGMAR1/PSMD6/PPP3R1/SDHD/PSMC4/ACTR10/TOMM40/KLC2/ITPR1/PLCB2/CAPN1/NDUFS3/ATP2A2/CDK5/DNALI1/PSMC1/CSNK2A1/DVL3/WNT10A	13.1413607391108
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	101/1442	205/9376	3.20346402354453	PLCB1/COL1A2/COL3A1/CYBA/COL1A1/MT-CO2/GAPDH/NDUFA13/COX4I1/NDUFA4/COX5B/CTSD/UQCR10/NDUFC2/MMP2/UQCRH/COX7A2/MT-CO1/SLC25A6/COX6A1/NDUFS5/UQCRB/MPC2/COX6B1/ATP5MC2/ATP5F1E/COX8A/NDUFA11/UQCR11/COX6C/G6PD/ATP5MC3/ATP5F1D/NDUFB2/CYBB/UQCRQ/ATP5PF/MT-CYB/NDUFS6/RYR2/RAC2/ATP5F1B/SLC25A5/COX7B/COX7C/ATP5F1A/NDUFB10/NDUFB11/NDUFB7/NDUFV2/RAC1/CD36/NDUFA1/PPP1CA/NDUFB9/NDUFS8/NDUFB4/NDUFB8/COX5A/ATP5F1C/UQCRC1/NDUFAB1/VDAC2/NCF4/ATP5PD/ATP5PO/NDUFA2/VDAC1/ATP5MC1/NDUFB3/NDUFB5/UQCRFS1/MT-CO3/PRKCB/CYC1/COX7A2L/NDUFA6/ATP5PB/NDUFA8/NDUFS7/TGFB1/NDUFA7/NDUFA12/GSR/PDHB/MT-ATP6/GYS1/NDUFC1/NDUFS2/NDUFB6/COX4I2/MAPK13/SLC25A4/SDHC/SDHD/PIK3CD/AKT1/PLCB2/CPT2/NDUFS3/ATP2A2	13.5986788725798
Genetic Information Processing	Translation	hsa03010	Ribosome	102/1442	222/9376	2.98744236608314	RPL19/RPS19/RPS27A/RPS14/RPS12/RPL28/RPLP1/RPL15/RPS2/RPS15/RPS23/RPS4X/RPL7A/RPL10/RPL11/RPS18/RPL23A/RPS7/RPS10/RPL13/RPS5/RPL29/RPL10A/RPL13A/RPLP0/RPL18/RPL26/RACK1/RPL14/RPL32/RPS9/RPS11/UBA52/RPL6/FAU/RPS26/RPL12/RPS6/RPL17/RPS27L/RPL7/RPS15A/RPL5/RPL27/RPL23/RPS3A/RPS3/RPL22/RPL30/RPL35/RPL18A/RPSA/RPL3/RPS24/RPL36AL/RPL24/RPL8/RPS8/RPL21/RPS13/RPS16/RPS25/RPLP2/RPL34/RPL9/RPL35A/RPL41/RPL27A/RPS20/RPL4/MRPL51/MRPL14/MRPS6/RPL39/MRPL41/MRPL20/RPS17/RPS28/MRPS34/MRPS21/MRPL28/MRPS24/MRPS12/MRPL17/RPL22L1/MRPL12/MRPL52/MRPL24/MRPL27/MRPS18C/MRPL32/MRPS15/MRPS23/MRPL13/MRPL36/MRPL48/MRPL22/MRPL37/MRPS7/RSL24D1/MRPL43/MRPS26	12.7757894807226
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	103/1442	227/9376	2.95028319697923	CYBA/NQO1/MT-CO2/CYP1B1/NDUFA13/COX4I1/HIF1A/NDUFA4/COX5B/UQCR10/NDUFC2/UQCRH/COX7A2/MT-CO1/SLC25A6/COX6A1/NDUFS5/GSTO1/UQCRB/COX6B1/ATP5MC2/ATP5F1E/COX8A/NDUFA11/UQCR11/COX6C/ATP5MC3/ATP5F1D/NDUFB2/UQCRQ/ATP5PF/MT-CYB/NDUFS6/HGF/ATP5F1B/SLC25A5/COX7B/COX7C/ATP5F1A/NDUFB10/NDUFB11/NDUFB7/NDUFV2/RAC1/HMOX1/GSTM3/CBR1/MAP2K2/AKR1C1/MGST3/NDUFA1/NDUFB9/NDUFS8/NDUFB4/NDUFB8/COX5A/ATP5F1C/PLD1/UQCRC1/NDUFAB1/VDAC2/SOD1/ATP5PD/AKR1A1/ATP5PO/NDUFA2/VDAC1/ATP5MC1/NDUFB3/PTPRJ/NDUFB5/UQCRFS1/MGST1/MT-CO3/CYP1A2/GSTT2B/CYC1/COX7A2L/NDUFA6/ATP5PB/NDUFA8/NDUFS7/MGST2/NDUFA7/NDUFA12/EPHX1/MT-ATP6/HRAS/NDUFC1/NDUFS2/NDUFB6/COX4I2/GRB2/ACP1/MAPK13/SLC25A4/SDHC/KEAP1/SDHD/PIK3CD/AKT1/AKR1C3/NDUFS3	12.680779887697
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	138/1442	368/9376	2.43828016643551	PFN1/MT-CO2/NDUFA13/COX4I1/NDUFA4/COX5B/UQCR10/NDUFC2/UQCRH/COX7A2/MT-CO1/PSMA7/COX6A1/NDUFS5/UQCRB/SQSTM1/TUBA1B/COX6B1/ATP5MC2/ATP5F1E/COX8A/NDUFA11/UQCR11/COX6C/ATP5MC3/ATP5F1D/NDUFB2/PSMB1/UQCRQ/ATP5PF/MT-CYB/NDUFS6/TUBA4A/TUBB/ATP5F1B/COX7B/COX7C/ATP5F1A/NDUFB10/PSMB5/PSMD2/NDUFB11/PSMB3/NDUFB7/NDUFV2/HSPA5/RAC1/PSMD8/NDUFA1/PSMA2/NDUFB9/NDUFS8/PSMB6/PSMA1/NDUFB4/NDUFB8/COX5A/PSMA6/TNFRSF1A/ATP5F1C/BAX/ADRM1/UQCRC1/NDUFAB1/PSMA4/SOD1/VCP/ATP5PD/BID/ATP5PO/ACTG1/GPX7/PSMC5/NDUFA2/HNRNPA1/VDAC1/ATP5MC1/PFN2/NDUFB3/NDUFB5/DNAH8/UQCRFS1/MT-CO3/PSMB2/CYCS/PSMA5/PSMB7/TUBB3/WIPI2/CYC1/PSMA3/SEM1/COX7A2L/PSMD3/NDUFA6/DNAH14/DCTN3/CASP1/ATP5PB/CHCHD10/NDUFA8/NDUFS7/PSMB4/ALYREF/PSMC2/TUBA1C/NDUFA7/NDUFA12/MT-ATP6/PSMD4/NDUFC1/NDUFS2/KIF5B/PSMC3/NDUFB6/GRIN2C/COX4I2/PSMC6/PSMD7/MAPK13/GPX8/PSMD1/ITPR3/DCTN4/DCTN6/PSMD9/SDHC/SIGMAR1/PSMD6/PPP3R1/SDHD/PSMC4/ACTR10/TOMM40/KLC2/NDUFS3/DNALI1/PSMC1	11.9998379873648
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	97/1442	238/9376	2.65000757584587	RPL19/RPS19/RPS27A/RPS14/RPS12/RPL28/RPLP1/RPL15/RPS2/RPS15/RPS23/RPS4X/NRP1/RPL7A/F13A1/RPL10/RPL11/RPS18/CCL2/RPL23A/RPS7/RPS10/RPL13/RPS5/RPL29/RPL10A/RPL13A/RPLP0/RPL18/RPL26/RPL14/RPL32/RPS9/RPS11/UBA52/RPL6/FAU/RPS26/RPL12/RPS6/RPL17/RPS27L/RPL7/RPS15A/RPL5/RPL27/RPL23/IL6/CXCL8/RPS3A/RPS3/RPL22/RPL30/RPL35/RPL18A/RPSA/RPL3/RPS24/RPL36AL/RPL24/RPL8/RPS8/MMP1/RPL21/RPS13/CYBB/RPS16/RPS25/RPLP2/CFB/RPL34/RPL9/RPL35A/RPL41/RPL27A/RPS20/RPL4/C1QA/RPL39/TNFRSF1A/C1QC/RPS17/RPS28/IKBKE/C3AR1/IL1B/PRKCB/SYK/CASP1/RPL22L1/C6/IRAK1/FCGR2A/TLR7/MAPK13/PIK3CD/RSL24D1	10.9918554937693
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	94/1442	235/9376	2.60083217753121	MT-CO2/NDUFA13/COX4I1/NDUFA4/COX5B/UQCR10/NDUFC2/UQCRH/COX7A2/MT-CO1/ATP5MG/COX6A1/NDUFS5/UQCRB/RPS6/COX6B1/ATP5MC2/ATP5F1E/COX8A/NDUFA11/UQCR11/COX6C/ATP5MF/ATP5MC3/ATP5F1D/GNAS/NDUFB2/UQCRQ/ATP5PF/MT-CYB/NDUFS6/ATP5F1B/COX7B/COX7C/ATP5F1A/NDUFB10/NDUFB11/NDUFB7/NDUFV2/NDUFA1/NDUFB9/NDUFS8/NDUFB4/NDUFB8/COX5A/ATP5F1C/UQCRC1/NDUFAB1/ATP5PD/ATP5PO/ACTG1/COX14/NDUFA2/NDUFAF3/ATP5MC1/NDUFB3/NDUFB5/UQCRFS1/MT-CO3/COX17/CYC1/COX7A2L/NDUFA6/ATP5ME/COA1/ATP5PB/NDUFA8/RPS6KB2/NDUFS7/NDUFAF8/COX16/NDUFA7/NDUFA12/MT-ATP6/HRAS/AKT1S1/NDUFC1/NDUFS2/NDUFB6/COX4I2/GRB2/CPT1C/MAPK13/ADCY8/SDHC/COA4/SDHD/SMARCB1/RPS6KA1/NDUFAF4/CPT2/MLST8/NDUFS3/COA3	10.5950998087758
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	71/1442	157/9376	2.94043128351458	MT-CO2/NDUFA13/COX4I1/NDUFA4/COX5B/UQCR10/NDUFC2/UQCRH/COX7A2/MT-CO1/COX6A1/NDUFS5/UQCRB/COX6B1/COX8A/NDUFA11/UQCR11/COX6C/IL6/CXCL8/NDUFB2/UQCRQ/MT-CYB/NDUFS6/COX7B/COX7C/NDUFB10/NDUFB11/NDUFB7/NDUFV2/RAC1/NDUFA1/NDUFB9/NDUFS8/IL1A/NDUFB4/NDUFB8/COX5A/TNFRSF1A/BAX/UQCRC1/NDUFAB1/BID/CDC42/NDUFA2/NDUFB3/NDUFB5/UQCRFS1/MT-CO3/CYCS/IL1B/CYC1/COX7A2L/ADIPOR1/NDUFA6/NDUFA8/NDUFS7/TGFB1/NDUFA7/NDUFA12/NDUFC1/NDUFS2/NDUFB6/COX4I2/MAPK13/SDHC/SDHD/PIK3CD/MAP3K11/AKT1/NDUFS3	10.4526968881616
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	33/1442	46/9376	4.66453597057227	POMP/PSMA7/PSMB1/PSMB5/PSMD2/PSMB3/PSMD8/PSMA2/PSMB6/PSMA1/PSMB8/PSMA6/ADRM1/PSMA4/PSMC5/PSMB2/PSMA5/PSMB7/PSMA3/SEM1/PSMD3/PSME2/PSMB4/PSMC2/PSMD4/PSMC3/PSMC6/PSMD7/PSMD1/PSMD9/PSMD6/PSMC4/PSMC1	10.6213385824957
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	77/1442	250/9376	2.00264077669903	AP2S1/CD63/LGMN/CLTA/CTSD/NPC2/ATP6V1G1/VAMP8/ATP6V0B/ATP6V1F/AP2M1/ATP6V0E1/CLTC/ATP6V0C/ASAH1/LAMTOR1/LAMTOR5/LAMTOR4/CTSB/LAMP1/CTSC/BLOC1S1/SLC2A6/PSAP/AP1S1/ATP6AP1/HEXA/ATP6V1A/CTSL/CTSA/FUCA1/NEU1/AP1S2/ATP6V0D1/SCARB2/LAMP2/CD68/CD164/CTSZ/FUCA2/ACP2/LAPTM4B/MANBA/ATP6V1D/ATP6V1E1/MCOLN2/RRAGA/OSBPL6/VPS29/CLN8/SMPD1/AKT1S1/BLOC1S4/GPR155/GLB1/TLR7/M6PR/GLA/AP1B1/LAMTOR2/CLCN7/ARSB/OSTM1/ATP6V1B2/BLOC1S2/VPS18/LAPTM5/MAN2B1/GNPTAB/CLN6/PLA2G15/ABCB9/NAGLU/MLST8/SLC15A4/CTBS/HYAL2	6.85010621481848
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	51/1442	144/9376	2.30282015718909	PLCB1/PSMA7/SLC25A6/PSMB1/SLC25A5/PSMB5/PSMD2/PSMB3/PSMD8/PSMA2/PSMB6/PSMA1/PSMA6/ADRM1/VDAC2/PSMA4/ITPR2/PSMC5/VDAC1/GRIA3/PSMB2/CYCS/PSMA5/PSMB7/PRKCB/WIPI2/PSMA3/SEM1/PSMD3/PSMB4/PSMC2/PSMD4/PSMC3/GRIN2C/PSMC6/PSMD7/PSMD1/SLC25A4/ITPR3/PSMD9/PSMD6/KAT5/TBPL1/PSMC4/PIK3CD/DAB1/AKT1/ITPR1/PLCB2/ATP2A2/PSMC1	6.71645312035914
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	35/1442	87/9376	2.61577948889633	MT-CO2/COX4I1/ATP1B1/COX5B/UQCR10/UQCRH/COX7A2/MT-CO1/COX6A1/UQCRB/COX6B1/COX8A/UQCR11/COX6C/ASPH/UQCRQ/MT-CYB/ATP1B3/RYR2/COX7B/COX7C/COX5A/UQCRC1/TPM3/TPM2/CACNG8/UQCRFS1/MT-CO3/CYC1/COX7A2L/ATP1A1/CACNA2D4/COX4I2/CACNB4/ATP2A2	6.45474969955515
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	49/1442	149/9376	2.13826806541995	PLCB1/NDUFA13/NDUFA4/NDUFC2/NDUFS5/GNG11/NDUFA11/GNGT1/GNG10/GNG5/NDUFB2/NDUFS6/GNAI2/NDUFB10/NDUFB11/NDUFB7/NDUFV2/GRIA4/NDUFA1/NDUFB9/NDUFS8/GNG2/NDUFB4/NDUFB8/NDUFAB1/GNB2/ITPR2/NDUFA2/NDUFB3/GRIA3/NDUFB5/PRKCB/GABRE/NDUFA6/NDUFA8/NDUFS7/NDUFA7/NDUFA12/NDUFC1/NDUFS2/NDUFB6/MAPK13/KCNJ5/ADCY8/ITPR3/ITPR1/KCNJ6/PLCB2/NDUFS3	5.97075974226304
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	48/1442	155/9376	2.01354749228222	HLA-C/CYBA/ITGA2/CALR/CD14/ATP6V1G1/ATP6V0B/SEC61G/ATP6V1F/TUBA1B/SEC61B/HLA-A/ATP6V0E1/FCGR3A/HLA-B/CYBB/ATP6V0C/TUBA4A/TUBB/ITGB1/RAC1/CD36/LAMP1/ATP6AP1/ATP6V1A/NCF4/CTSL/ACTG1/RAB5C/FCGR1A/MRC2/COLEC12/ATP6V0D1/SEC61A1/LAMP2/TUBB3/CD209/ATP6V1D/ATP6V1E1/CLEC7A/TUBA1C/CORO1A/FCGR2A/RAB7B/M6PR/ATP6V1B2/ITGAM/HLA-F	5.42429264270261
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	66/1442	248/9376	1.73039237618004	PFN1/GAPDH/ARPC1B/CD14/ARPC3/TUBA1B/TXN/BRK1/IL6/CXCL8/S100A10/RPS3/ARPC2/MYL12A/DYNLL1/DYNLT1/TUBA4A/TUBB/RAC1/MYL12B/PYCARD/MAP2K2/SKP1/HSP90B1/ARPC5/TNFRSF1A/BAX/ACTG1/RAB5C/ARPC1A/CDC42/DYNLRB1/ACTR3C/PFN2/LY96/CYTH4/CYCS/ACTR2/IL1B/TUBB3/RAB9A/DCTN3/CASP1/PTPRC/RALA/MYL5/IRAK1/NCKAP1L/TUBA1C/HRAS/KIF5B/RAB7B/TNFRSF10B/M6PR/MAPK13/DCTN4/DCTN6/PIK3CG/KPNA3/VPS18/PIK3CD/AHNAK2/ACTR10/ARPC5L/KLC2/AKT1	4.96954269844928
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	21/1442	51/9376	2.67732724157624	ATP6V1G1/ATP6V0B/SEC61G/ATP6V1F/SEC61B/ATP6V0E1/GNAS/ATP6V0C/ATP6AP1/KDELR1/ATP6V1A/KDELR2/ACTG1/ATP6V0D1/SEC61A1/ATP6V1D/ATP6V1E1/PDIA4/KCNQ1/ATP6V1B2/ERO1A	5.12036167816718
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	23/1442	59/9376	2.53470932556007	GPX4/GCLM/GSTP1/GSTO1/G6PD/HPGDS/GSTM3/PGD/MGST3/LAP3/GPX7/MGST1/IDH1/GSTT2B/PRDX6/IDH2/SRM/MGST2/GSR/GPX8/RRM2B/ODC1/SMS	5.04122707989954
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	60/1442	227/9376	1.71861157105586	HLA-C/PLCB1/B2M/CCL2/CALR/GNG11/PDIA3/HLA-A/GNGT1/IL6/CALM2/GNG10/CXCL8/HLA-B/CCL3/GNG5/GNAS/GNAI2/RAC2/CDK6/RAC1/MAP2K2/CDKN2A/CALM1/CCL4L2/CCND1/CCL4/GNG2/TNFRSF1A/BAX/GNB2/BID/EIF4EBP1/ITPR2/CCL3L1/CCR1/CYCS/IL1B/PRKCB/CALM3/TAPBP/RPS6KB2/HRAS/RB1/CDK4/GRB2/MAPK13/ADCY8/CALML4/ITPR3/PPP3R1/RAC3/PIK3CD/IL10RA/AKT1/E2F3/ITPR1/PLCB2/HLA-F/ELK1	4.67242663600129
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	49/1442	174/9376	1.83104564222743	CALR/P4HB/SEC61G/SEC61B/PDIA3/OSTC/SSR4/DAD1/SSR2/RPN2/HSPA5/CKAP4/RBX1/SKP1/HSP90B1/HSPA8/TUSC3/TRAM1/BAX/VCP/STUB1/KRTCAP2/SEC61A1/PDIA6/ERP29/BCAP31/TMEM258/FBXO2/DDOST/RAD23A/LMAN2/RPN1/LMAN1/SEC62/DNAJB11/UBXN1/UBXN6/PDIA4/PRKCSH/UBE2J2/DERL2/ERO1A/MAN1B1/BAG1/OS9/NGLY1/CAPN1/GANAB/ERLEC1	4.71715944945755
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	32/1442	98/9376	2.12312830818874	ARPC1B/CFL1/ARPC3/FCGR3A/ARPC2/MARCKS/RAC2/RAC1/ARPC5/PLD1/ARPC1A/CDC42/FCGR1A/PLPP2/LYN/ACTR3C/ACTR2/PRKCB/SYK/PTPRC/RPS6KB2/BIN1/VAV1/FCGR2A/WAS/HCK/SCIN/PIK3CD/ARPC5L/AKT1/MARCKSL1/LIMK2	4.76472014762068
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	30/1442	95/9376	2.05328856120885	CCL2/ATP6V1G1/ATP6V0B/ATP6V1F/ATP6V0E1/IL6/CXCL8/CCL3/MMP1/ATP6V0C/IL11/IL1A/ATP6AP1/ICAM1/ATP6V1A/CXCL1/CTSL/CXCL6/CD86/CCL3L1/ATP6V0D1/TNFSF13B/CD28/CXCL5/IL1B/ATP6V1D/ATP6V1E1/TGFB1/TNFRSF11A/ATP6V1B2	4.39879734619778
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	40/1442	142/9376	1.83157195600789	CYBA/NQO1/GSTP1/CCL2/MMP2/SUMO2/GSTO1/SQSTM1/TXN/CALM2/RAC2/RAC1/HMOX1/GSTM3/CALM1/MGST3/BMP4/HSP90B1/IL1A/MEF2C/TNFRSF1A/SUMO1/ICAM1/CTSL/ACTG1/MGST1/IL1B/GSTT2B/CALM3/MGST2/MAPK7/MAPK13/CALML4/KEAP1/ACVR2A/RAC3/PIK3CD/VCAM1/AKT1/ASS1	4.25668234482593
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	51/1442	196/9376	1.6918678705879	HLA-C/RPS27A/HIF1A/UBA52/UBB/GNG11/HLA-A/GNGT1/IL6/CALM2/GNG10/CXCL8/HLA-B/GNG5/CDK6/RAC1/MAP2K2/CALM1/CCND1/GNG2/TNFRSF1A/BAX/ICAM1/GNB2/BID/CXCL1/ITPR2/CD86/CCR1/LYN/IKBKE/CYCS/SYK/CALM3/CD200R1/HRAS/RB1/CDK4/MAPK13/CALML4/HCK/MICA/ITPR3/PIK3CG/PPP3R1/PIK3CD/AKT1/E2F3/ITPR1/ATG3/HLA-F	4.17303501141184
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	23/1442	67/9376	2.23205746579171	GAPDH/PKM/LDHB/TPI1/GPI/PGAM1/ENO1/LDHA/AKR1A1/ALDH2/PFKP/PGK1/ADH5/HK2/PDHB/GALM/G6PC3/PGM1/DLD/ADPGK/ALDH3A2/ALDH9A1/MINPP1	4.31458492016477
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	34/1442	116/9376	1.90578219905304	GAPDH/PKM/ME1/TPI1/G6PD/TKT/GPI/PGD/TALDO1/PGAM1/ENO1/ACAT2/PGLS/GCSH/PFKP/PGK1/IDH1/MDH2/IDH2/MDH1/ADH5/HK2/PGP/PDHB/ESD/PHGDH/ECHS1/DLD/ADPGK/SDHC/GPT2/SDHD/ACO1/ACO2	4.18474937354885
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	54/1442	214/9376	1.64071188769492	HLA-C/B2M/CALR/CFL1/ELOB/GNG11/PDIA3/HLA-A/GNGT1/CALM2/GNG10/HLA-B/GNG5/GNAI2/RNF7/RAC2/RAC1/MAP2K2/CALM1/RBX1/SKP1/ELOC/GNG2/AP1S1/TNFRSF1A/BAX/GNB2/BID/ITPR2/AP1S2/BST2/CYCS/PRKCB/CALM3/TAPBP/RPS6KB2/IRAK1/ATM/HRAS/CD4/CUL4B/MAPK13/AP1B1/CALML4/ITPR3/PPP3R1/CCNB2/RAC3/PIK3CD/DDB1/AKT1/ITPR1/HLA-F/LIMK2	4.04200359265692
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	13/1442	31/9376	2.72667889579885	SRP14/SEC61G/SEC61B/SEC11A/SPCS1/HSPA5/TMEM208/SPCS2/SRP9/SEC61A1/SEC62/SEC11C/BAG6	4.10511138364664
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	17/1442	47/9376	2.3518163307463	PKM/ME1/LDHB/LDHA/ACAT2/AKR1A1/ALDH2/MDH2/MDH1/ADH5/GLO1/PDHB/ACACA/DLD/ALDH3A2/GRHPR/ALDH9A1	3.96069355281809
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	29/1442	101/9376	1.86693398882191	PLCB1/COL1A2/COL3A1/COL1A1/CCL2/MMP2/IL6/CXCL8/CYBB/RAC1/CCND1/IL1A/BAX/ICAM1/CDC42/IL1B/PRKCB/TGFB1/HRAS/CDK4/VEGFB/MAPK13/FN1/PIK3CD/VEGFC/VCAM1/AKT1/PLCB2/PLCD4	3.73432341876034
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	59/1442	253/9376	1.51629543946977	PLCB1/PFN1/RPS27A/ARPC1B/CD14/ARPC3/UBA52/UBB/SQSTM1/CXCL8/ARPC2/MYL12A/ITGB1/RAC1/MYL12B/PYCARD/RBX1/SKP1/ARPC5/TNFRSF1A/BAX/ACTG1/ITPR2/ARPC1A/CDC42/VDAC1/ACTR3C/PFN2/CYTH4/SEPTIN7/CYCS/ACTR2/IL1B/WIPI2/TIFA/TLN1/CASP1/HK2/RPS6KB2/CBX3/CAPNS1/MYL5/TNIP1/ATM/RRAGA/SEPTIN2/AKT1S1/UBE2V1/MAPK13/ITPR3/UBE2V2/PIK3CD/CTTN/ARPC5L/AKT1/ITPR1/PLCB2/CAPN1/PLCD4	3.54904807541459
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	15/1442	42/9376	2.32217158708143	SLC7A11/FTH1/FTL/GPX4/GCLM/PRNP/CYBB/HMOX1/SLC40A1/NCOA4/VDAC2/SLC39A8/SLC3A2/ATG7/SAT2	3.66100850127898
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	23/1442	78/9376	1.91728013087236	CFL1/CD14/IL6/CALM2/CXCL8/GNAI2/ITGB1/C1QA/PYCARD/CALM1/IL1A/C1QC/CXCL6/LY96/CXCL5/IL1B/C4BPB/CALM3/CASP1/IRAK1/MAPK13/CALML4/ITGAM	3.46798082186795
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	39/1442	157/9376	1.61516647967702	HLA-C/SLC25A6/SQSTM1/HLA-A/IL6/CALM2/CXCL8/HLA-B/CDK6/SLC25A5/MAP2K2/CDKN2A/CALM1/PPP1CA/CCND1/IL1A/VDAC2/EIF4EBP1/ITPR2/CCND2/VDAC1/CALM3/TGFB1/ATM/HRAS/RB1/CDK4/MAPK13/CALML4/SLC25A4/ITPR3/PPP3R1/CCNB2/PIK3CD/AKT1/E2F3/ITPR1/CAPN1/HLA-F	3.31377297534331
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	18/1442	56/9376	2.08995442837329	OSTC/MGAT4B/DAD1/RPN2/TUSC3/KRTCAP2/ST6GAL1/TMEM258/DDOST/RPN1/MGAT2/FUT8/SRD5A3/B4GALT2/ALG3/MAN1B1/GANAB/DOLK	3.48751888388742
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	9/1442	20/9376	2.92593619972261	MSMO1/SQLE/DHCR7/DHCR24/EBP/FDFT1/CYP51A1/HSD17B7/NSDHL	3.6756483679768
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	15/1442	44/9376	2.21661833312319	OSTC/MGAT4B/DAD1/RPN2/TUSC3/HEXA/KRTCAP2/TMEM258/DDOST/RPN1/MGAT2/FUT8/B4GALT2/ALG3/MAN1B1	3.44838303659146
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	9/1442	21/9376	2.78660590449772	ALDH2/BCAT1/ENPP1/VNN1/PANK1/ALDH3A2/PPCS/AASDHPPT/PANK3	3.4941270048757
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	47/1442	205/9376	1.4907208822435	HLA-C/B2M/CALR/PDIA3/HLA-A/IL6/HLA-B/CDK6/PSMD2/RAC1/PSMD8/CCND1/BAX/ADRM1/ICAM1/BID/PSMC5/CCND2/LYN/IKBKE/CYCS/SEM1/SYK/PSMD3/TAPBP/PSMC2/IRAK1/PSMD4/RB1/CD40/HDAC2/PSMC3/PSMC6/CDK4/PSMD7/MAPK13/PSMD1/JAK3/SKP2/PSMD6/PSMC4/PIK3CD/HDAC1/AKT1/E2F3/HLA-F/PSMC1	3.02848406980741
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	14/1442	42/9376	2.16736014794267	CYP1B1/TDO2/ACAT2/ALDH2/KYNU/INMT/CYP1A2/HAAO/HADHA/ECHS1/DLD/ALDH3A2/IL4I1/ALDH9A1	3.23234553474729
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	50/1442	224/9376	1.4513572419259	HLA-C/B2M/NRP1/CALR/SLC25A6/HLA-A/IL6/HLA-B/TSPO/FDPS/RAN/SLC25A5/ANAPC11/MAP2K2/CDKN2A/CCND1/TNFRSF1A/VAC14/BAX/VDAC2/ICAM1/CCND2/VDAC1/TLN1/TGFB1/SPI1/ATM/HRAS/RB1/RANBP1/CD40/CD4/CDK4/ANAPC16/ADCY8/XPO1/SLC25A4/JAK3/PPP3R1/KAT5/CCNB2/TBPL1/PIK3CD/CDKN2C/MAP3K1/AKT1/E2F3/HLA-F/ELK1/ANAPC10	2.91479884508424
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	11/1442	30/9376	2.38409616273694	ACLY/IDH1/MDH2/IDH2/MDH1/PDHB/DLD/SDHC/SDHD/ACO1/ACO2	3.23695136311153
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	14/1442	43/9376	2.11695642357191	ACAT2/ALDH2/HADHB/ACADVL/ADH5/HADHA/ACAA2/ECHS1/CPT1C/ALDH3A2/ALDH9A1/ECI2/ACAA1/CPT2	3.1295507258207
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	23/1442	85/9376	1.75938647303582	NME2/GUK1/LACC1/APRT/AK1/AK4/DGUOK/ENPP1/NME4/NT5C/TYMS/TYMP/AK6/NME1/NME3/RRM2B/DUT/DCK/AK3/HDDC2/CMPK2/GMPR/NT5C3B	2.99821836430172
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	17/1442	57/9376	1.93921697447502	FADS1/SCD/ACAT2/ELOVL2/FADS2/HADHB/ACADVL/HADHA/TECR/ACACA/FASN/ACAA2/ECHS1/CPT1C/HACD4/ACAA1/CPT2	3.03208153251924
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	15/1442	48/9376	2.03190013869626	ACAT2/ALDH2/HMGCLL1/HMGCS1/HADHB/BCAT1/HADHA/HSD17B10/ACAA2/ECHS1/DLD/ALDH3A2/IL4I1/ALDH9A1/ACAA1	3.05552746038691
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	21/1442	76/9376	1.79662749105774	PLCB1/ATP1B1/CALM2/GNAS/GNAI2/ATP1B3/CALM1/ACTG1/SLC4A2/ITPR2/HRH2/PRKCB/CALM3/ATP1A1/ADCY8/KCNQ1/CALML4/ITPR3/KCNJ15/ITPR1/PLCB2	2.97264317823865
Organismal Systems	Immune system	hsa04611	Platelet activation	31/1442	126/9376	1.59971820443388	PLCB1/COL1A2/COL3A1/COL1A1/ITGA2/VAMP8/MYL12A/GNAS/FCER1G/GNAI2/ITGB1/MYL12B/PPP1CA/ACTG1/ITPR2/ORAI1/LYN/PTGS1/TBXAS1/SYK/TLN1/GUCY1A1/FCGR2A/MAPK13/ADCY8/ITPR3/PIK3CG/PIK3CD/AKT1/ITPR1/PLCB2	2.88924126230401
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	34/1442	142/9376	1.55683616260671	RPS27A/UBA52/UBB/ELOB/RNF7/UBE2M/ANAPC11/WWP1/RBX1/SKP1/ELOC/NEDD4L/STUB1/UBE2S/FBXO2/UBE2E3/UBE2L3/PIAS2/UBA6/UBE2I/ANAPC16/CUL4B/TRIM32/UBE2J2/KEAP1/SKP2/CDC34/DDB1/TRIM37/MAP3K1/UBE2C/UBE2A/UBE2O/ANAPC10	2.85035425401732
NA	NA	hsa04517	IgSF CAM signaling	63/1442	299/9376	1.37000357177647	CDH2/NRP1/ARPC1B/CADM3/ARPC3/TUBA1B/ARPC2/MYL12A/DYNLL1/MTSS1/MYL6/TUBA4A/TUBB/ITGB1/SLIT3/RAC1/MYL12B/MAP2K2/GRIP1/ROBO2/CASK/ARPC5/ICAM1/NRP2/ACTG1/PTPRD/RDX/ARPC1A/ROBO1/CDC42/CD86/LYN/ACTR3C/SLITRK4/CD28/LMO7/ACTR2/TUBB3/PRKCB/KIRREL1/CD209/MYL6B/TUBA1C/VAV1/DOK2/GRB2/UNC5B/EPB41L1/APP/MAPK13/PPFIA4/IL1RAPL1/KIRREL3/ITGAM/CNTNAP1/PIK3CD/ARPC5L/AKT1/PTPN6/ANK3/RAPGEF6/PTPRS/PLXNA3	2.77199545106428
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	9/1442	23/9376	2.54429234758488	FDPS/IDI1/ACAT2/HMGCS1/MVD/HMGCR/MVK/RCE1/PCYOX1	3.16111387166555
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	47/1442	212/9376	1.44149896632036	PLCB1/PFN1/CALM2/GNAS/GNAI2/ID1/HGF/RAC2/ITGB1/EFNA5/RAC1/MAP2K2/CALM1/SIPA1L1/ACTG1/CDC42/FGF10/CSF1R/PFN2/FYB1/PDGFC/PRKCB/CALM3/TLN1/RALA/FGFR4/FGF7/HRAS/VAV1/FPR1/KITLG/VEGFB/ADORA2B/MAPK13/ADCY8/CALML4/LPAR5/ITGAM/RAC3/PIK3CD/VEGFC/EFNA4/RGS14/AKT1/PLCB2/RAPGEF6/FGFR3	2.77189804160337
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	25/1442	97/9376	1.67579392882165	PLCB1/GNG11/GNGT1/CALM2/GNG10/GNG5/GNAS/GNAI2/RYR2/GRIA4/CALM1/GNG2/GNB2/GRIA3/PRKCB/CALM3/GUCY1A1/GRIN2C/KCNJ5/ADCY8/CALML4/ITPR3/ITPR1/KCNJ6/PLCB2	2.85214588750801
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	33/1442	138/9376	1.55484532352409	ARPC1B/CCL2/ARPC3/IL6/CXCL8/ARPC2/RAC2/ITGB1/RAC1/PYCARD/MAP2K2/ARPC5/SKAP2/ACTG1/ARPC1A/CDC42/ACTR3C/FYB1/ACTR2/IL1B/CASP1/IRAK1/VAV1/FCGR2A/CD4/WAS/MAPK13/FN1/RAC3/PIK3CD/ARPC5L/RPS6KA1/AKT1	2.79926919255807
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	18/1442	63/9376	1.85773726966515	POLR2L/RBX1/POLR2K/POLR2J/POLR2E/RAD23A/PCNA/GTF2H5/POLD4/POLR2G/CETN2/POLR2I/POLR2F/CUL4B/POLR2B/DDB1/ERCC6/POLR2A	2.91207076684776
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	21/1442	78/9376	1.75056011949216	ARPC1B/CLTA/ARPC3/CLTC/ARPC2/ITGB1/RAC1/SHC3/ARPC5/SHC1/ACTG1/ARPC1A/CDC42/ACTR3C/ACTR2/SEPTIN2/DNM1/FN1/PIK3CD/CTTN/ARPC5L	2.83765887045024
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	24/1442	93/9376	1.67795624356852	PLCB1/MMP2/CALM2/GNAS/MMP14/MAP2K2/CALM1/PLD1/ITPR2/CDC42/PRKCB/CALM3/MAP3K2/HRAS/MAPK7/GRB2/MAPK13/ADCY8/CALML4/ITPR3/MAP3K1/ITPR1/PLCB2/ELK1	2.80105175951124
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	11/1442	32/9376	2.23509015256588	AKR1B1/PFKP/HK2/GALM/G6PC3/GLB1/GLA/GALE/AKR1B10/B4GALT2/PGM1	2.98352309278287
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	15/1442	50/9376	1.9506241331484	LAP3/ALDH2/SMOX/P4HA1/SRM/P4HA2/OAT/ALDH3A2/SAT2/ODC1/GATM/ALDH9A1/ARG2/AZIN2/SMS	2.87321617263209
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	43/1442	193/9376	1.44865004707049	CXCL14/PLCB1/CCL2/GNG11/GNGT1/GNG10/CXCL8/CCL3/GNG5/GNAI2/RAC2/RAC1/SHC3/CCL4L2/CCL4/GNG2/SHC1/GNB2/CXCL1/CXCL6/CDC42/CCL3L1/CCR1/LYN/DOCK2/CXCL5/PRKCB/HRAS/VAV1/GRB2/WAS/ADCY8/HCK/JAK3/CX3CR1/PIK3CG/CCL28/RAC3/PIK3CD/CCL8/AKT1/PLCB2/ARRB2	2.68482665170509
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	47/1442	216/9376	1.41480454101813	PLCB1/CYBA/CCL2/CD14/IL6/CALM2/CXCL8/CCL3/MMP1/CYBB/HSPA5/RAC1/PYCARD/CALM1/CD36/POU2F2/HSP90B1/HSPA8/TNFRSF1A/BAX/ICAM1/NCF4/BID/CXCL1/CDC42/CCL3L1/LYN/IKBKE/LY96/CYCS/IL1B/CALM3/CASP1/IRAK1/HRAS/VAV1/CD40/TNFRSF10B/MAPK13/CALML4/ERO1A/PPP3R1/PIK3CD/VCAM1/AKT1/ITPR1/PLCB2	2.62932827182412
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	19/1442	70/9376	1.76485040618189	HLA-C/HLA-A/HLA-B/RAC2/RAC1/CCND1/ICAM1/EIF4G2/BID/ACTG1/CD86/CD28/CYCS/SNTA1/EIF4G1/SGCA/CD40/RAC3/HLA-F	2.73820631609637
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	53/1442	250/9376	1.37844105409154	HLA-C/AP2S1/ARPC1B/DAB2/CLTA/ARPC3/AP2M1/HLA-A/CLTC/HLA-B/ARPC2/FOLR2/SNX3/SH3KBP1/CAPZB/WWP1/PSD3/HSPA8/SH3GLB1/ARPC5/PLD1/SNX6/CHMP5/NEDD4L/RAB5C/ARPC1A/SNX2/CDC42/ACTR3C/CHMP2A/RAB10/CYTH4/ACTR2/SNF8/CAPZA2/FGFR4/BIN1/VPS25/VPS29/VPS28/HRAS/KIF5B/ACAP2/PSD4/DNM1/SPG21/ARF3/ARPC5L/ARAP1/CHMP1B/HLA-F/ARRB2/FGFR3	2.58553359969029
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	20/1442	75/9376	1.73388811835414	CDK6/CDKN2A/CCND1/CD82/BAX/BID/CCND2/CCNG1/CYCS/SIVA1/ZMAT3/EI24/ATM/TNFRSF10B/CDK4/CCNG2/PMAIP1/RRM2B/CCNB2/TP53I3	2.72030648197025
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	36/1442	158/9376	1.48148668340385	ATP6V1G1/ATP6V1F/RPS6/DDIT4/WNT2/LAMTOR1/LAMTOR5/LAMTOR4/MAP2K2/TNFRSF1A/ATP6V1A/SLC3A2/EIF4EBP1/FZD4/FZD2/PRKCB/EIF4E2/FZD7/ATP6V1D/RPS6KB2/ATP6V1E1/TBC1D7/RRAGA/HRAS/AKT1S1/GRB2/LAMTOR2/ATP6V1B2/SKP2/PIK3CD/STRADB/RPS6KA1/AKT1/MLST8/DVL3/WNT10A	2.60205601900642
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	38/1442	170/9376	1.45340621685567	NQO1/GSTP1/GSTO1/WNT2/HGF/CDK6/HMOX1/GSTM3/SHC3/MAP2K2/CDKN2A/MGST3/CCND1/SHC1/BAX/ACTG1/FZD4/MGST1/FZD2/PRKCB/GSTT2B/TXNRD1/FZD7/RPS6KB2/TGFB1/MGST2/HRAS/RB1/CDK4/GRB2/KEAP1/PIK3CD/SMARCB1/AKT1/E2F3/DVL3/WNT10A/ELK1	2.54330600319148
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	35/1442	154/9376	1.47774555541546	NQO1/NME2/GCLM/TDO2/AK1/QPRT/AKR1A1/ALDH2/AK4/KYNU/BCAT1/MMAB/GGH/PTS/NME4/MOCS2/HAAO/PANK1/PDXK/GGCX/RDH11/PDXP/AK6/NME1/UROS/DLD/ALDH3A2/NME3/PPCS/ALAS1/AK3/NAPRT/UROD/PANK3/CMPK2	2.54839431275019
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	35/1442	154/9376	1.47774555541546	PLCB1/CALM2/GNAS/GNAI2/MYL6/RYR2/MAP2K2/CALM1/PPP1CA/CCND1/MEF2C/ACTG1/ITPR2/CACNG8/EEF2/PRKCB/CALM3/GUCY1A1/MYL6B/HRAS/CACNA2D4/MAPK7/CACNB4/KCNJ5/ADCY8/CALML4/TRPM2/ITPR3/PIK3CG/KCNJ12/PPP3R1/ITPR1/KCNJ6/PLCB2/ELK1	2.54839431275019
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	43/1442	200/9376	1.39794729542302	GAPDH/ARPC1B/ARPC3/TUBA1B/BRK1/IL6/CXCL8/RPS3/ARPC2/TUBA4A/TUBB/ITGB1/RAC1/PYCARD/ARPC5/TNFRSF1A/BAX/TMBIM6/MYO1B/ACTG1/ARPC1A/CDC42/ACTR3C/CYTH4/CYCS/ACTR2/IL1B/TUBB3/CASP1/CLDN11/MYO5B/IRAK1/NCKAP1L/CLDN23/TUBA1C/FCGR2A/TNFRSF10B/MAPK13/MYO5A/LPAR5/CTTN/ARPC5L/PTPN6	2.42513557889022
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	7/1442	18/9376	2.52858683926645	HEXA/FUCA1/NEU1/FUCA2/MANBA/GLB1/MAN2B1	2.76730494119717
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	15/1442	54/9376	1.80613345661889	GCLM/LDHB/LACC1/LDHA/ADI1/BCAT1/MDH2/MDH1/SRM/PHGDH/AHCYL2/DNMT3A/IL4I1/APIP/SMS	2.53262824962759
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	25/1442	105/9376	1.54811439138762	CD14/CXCL8/CCL4L2/CCL4/TNFRSF1A/CSNK2B/ICAM1/CXCL1/LYN/TNFSF13B/LY96/EDA/IL1B/PRKCB/SYK/IRAK1/ATM/UBE2I/CD40/TNFRSF11A/CARD11/PLAU/VCAM1/BCL2A1/CSNK2A1	2.40782397494795
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	14/1442	50/9376	1.82058252427184	CCL2/GYPC/IL6/CXCL8/HGF/CR1/CD36/ICAM1/LRP1/IL1B/TGFB1/CD40/ACKR1/VCAM1	2.4801716025329
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	39/1442	181/9376	1.40100075861488	CTSD/CD14/ATP6V0B/IL6/CALM2/FCGR3A/ATP6V0C/FCER1G/CR1/CALM1/LAMP1/IL1A/TNFRSF1A/ATP6AP1/BAX/BID/RAB5C/FCGR1A/MRC2/ATP6V0D1/LAMP2/CYCS/IL1B/SYK/CALM3/LSP1/CD209/TLR1/TGFB1/CLEC7A/IRAK1/CORO1A/FCGR2A/MAPK13/CALML4/ITGAM/PPP3R1/IL10RA/AKT1	2.32236664435232
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	19/1442	75/9376	1.64719371243643	GAPDH/PKM/TPI1/TKT/TALDO1/PGAM1/ENO1/PFKP/BCAT1/PGK1/IDH1/IDH2/PHGDH/ASL/GPT2/ACO1/ASS1/ARG2/ACO2	2.39895592666027
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	17/1442	65/9376	1.7005441160781	AKR1B1/PLPP4/GPAM/DGKI/AKR1A1/ALDH2/PLPP2/GK/AGPAT2/PNPLA3/DGAT2/GLA/AKR1B10/ALDH3A2/ALDH9A1/LIPG/MBOAT2	2.41610706386531
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	43/1442	204/9376	1.37053656414022	COL1A2/COL1A1/ITGA2/CD63/HIF1A/MMP2/RPS6/WNT2/PLAUR/HGF/ITGB1/RAC1/TWIST1/MAP2K2/PPP1CA/VTN/CCND1/CTSL/ACTG1/ITPR2/RDX/CDC42/FZD4/FZD2/PRKCB/FZD7/RPS6KB2/TGFB1/HRAS/VAV1/GRB2/MAPK13/ITPR3/PLAU/FN1/PIK3CD/CTTN/AKT1/ITPR1/PTPN6/ANK3/WNT10A/ELK1	2.2810578582024
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	12/1442	41/9376	1.90304793477893	MMP2/CXCL8/MMP1/MAP2K2/CDKN2A/CCND1/HRAS/RB1/TYMP/CDK4/E2F3/FGFR3	2.47040263163346
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	25/1442	107/9376	1.51917767379159	PLCB1/PKM/LDHB/CALM2/GNAS/PGAM1/CALM1/LDHA/PPP4C/ITPR2/PFKP/CALM3/PRMT1/PDHB/GYS1/ACACA/G6PC3/CPT1C/CALML4/ITPR3/PPP3R1/AKT1/ITPR1/PHKG2/PLCB2	2.30257415841422
Human Diseases	Cancer: specific types	hsa05214	Glioma	19/1442	76/9376	1.625520110957	CALM2/CDK6/SHC3/MAP2K2/CDKN2A/CALM1/CCND1/SHC1/BAX/PRKCB/CALM3/HRAS/RB1/CDK4/GRB2/CALML4/PIK3CD/AKT1/E2F3	2.33415004071538
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	18/1442	71/9376	1.6484147604071	ATP6V1G1/ATP6V0B/ATP6V1F/ATP6V0E1/CXCL8/ATP6V0C/RAC1/ATP6AP1/ATP6V1A/CXCL1/CDC42/LYN/ATP6V0D1/ATP6V1D/ATP6V1E1/ADAM10/MAPK13/ATP6V1B2	2.33800829924011
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	18/1442	71/9376	1.6484147604071	SLC16A3/PKM/HIF1A/LDHB/G6PD/MAP2K2/PGAM1/LDHA/PFKP/IDH1/IDH2/HK2/PDHB/HRAS/TIGAR/PIK3CD/AKT1/FGFR3	2.33800829924011
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	9/1442	28/9376	2.08995442837329	ATP6V1G1/ATP6V1F/ATP6V0E1/ATP6V0C/ATP6V1A/ATP6V0D1/ATP6V1D/ATP6V1E1/ATP6V1B2	2.46235221388715
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	34/1442	157/9376	1.40809385407741	HIF1A/CALR/DUSP4/RAC1/C1QA/MAP2K2/CD36/C1QC/SIRPA/RAB5C/LRP1/UQCRFS1/ADAM9/CD47/CASP1/TGFB1/PROS1/ADAM10/VPS8/RAB7B/CPT1C/MAPK13/DNMT3A/EPOR/CX3CR1/GAS6/ODC1/TMEM30A/VPS18/STAB1/PLA2G15/PTPN6/ATP2A2/ARG2	2.19831611396545
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	19/1442	77/9376	1.60440946016535	RUNX1/CDK6/SHC3/MAP2K2/CDKN2A/CCND1/SHC1/BAX/TGFB1/HRAS/RB1/HDAC2/CDK4/GRB2/CTBP1/PIK3CD/HDAC1/AKT1/E2F3	2.27028647721315
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	17/1442	67/9376	1.64978160515039	PLCB1/CALM2/MAP2K2/CALM1/PPP1CA/ITPR2/PRKCB/CALM3/HRAS/GRIN2C/ADCY8/CALML4/ITPR3/PPP3R1/RPS6KA1/ITPR1/PLCB2	2.27549281817047
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/1442	24/9376	2.16736014794267	HS3ST3A1/HS2ST1/HS3ST3B1/EXT1/B3GALT6/B3GAT3/HS6ST3/B4GALT7	2.44107096516893
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	19/1442	78/9376	1.58384010811195	CYBA/FCGR3A/CYBB/EEF1A1/ITGB1/CR1/IL1A/NCF4/FCGR1A/IL1B/PRKCB/TGFB1/IRAK1/FCGR2A/MAPK13/ITGAM/PTPN6/MARCKSL1/ELK1	2.20733691903253
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	18/1442	73/9376	1.60325271217677	HGF/CDK6/MAP2K2/CDKN2A/CCND1/RARB/BAX/PRKCB/EML4/HRAS/RB1/KIF5B/CDK4/GRB2/JAK3/PIK3CD/AKT1/E2F3	2.20582661767961
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	25/1442	110/9376	1.47774555541546	GAPDH/HIF1A/ELOB/LDHB/RPS6/IL6/CYBB/HMOX1/MAP2K2/ENO1/RBX1/TIMP1/LDHA/ELOC/EIF4EBP1/PFKP/PGK1/PRKCB/HK2/MKNK1/EIF4E2/RPS6KB2/PDHB/PIK3CD/AKT1	2.14866653758052
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	21/1442	89/9376	1.53419875640886	PLCB1/TUBA1B/GNAS/GNAI2/TUBA4A/TUBB/MAP2K2/ITPR2/PDGFC/TUBB3/PRKCB/GUCY1A1/MAP3K2/TUBA1C/HRAS/MAPK7/GRB2/ADCY8/ITPR3/ITPR1/PLCB2	2.15865045379376
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	26/1442	116/9376	1.45736285809938	CYBA/MMP2/MYL12A/CYBB/GNAI2/RAC2/ITGB1/RAC1/MYL12B/CD99/ICAM1/NCF4/ACTG1/CDC42/PRKCB/ARHGAP5/CLDN11/MYL5/CLDN23/VAV1/MAPK13/ITGAM/PIK3CD/VCAM1/THY1/TXK	2.11303438720353
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	29/1442	133/9376	1.41774686369182	PLCB1/GNG11/GNGT1/CALM2/GNG10/GNG5/GNAS/GNAI2/GRIA4/CALM1/PPP1CA/GNG2/GNB2/ITPR2/GRIA3/PRKCB/CALM3/COMT/KIF5B/MAPK13/KCNJ5/CALML4/ITPR3/PPP2R1A/AKT1/ITPR1/KCNJ6/PLCB2/ARRB2	2.06849612820424
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	7/1442	21/9376	2.16736014794267	CSGALNACT1/CHPF2/DSE/CSGALNACT2/B3GALT6/B3GAT3/B4GALT7	2.2830466456389
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	6/1442	17/9376	2.29485192135106	LAMP1/NRP2/PCDH7/PCDH20/LAMP2/CD209	2.27799104723954
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	28/1442	130/9376	1.40044809559373	PLCB1/COL1A2/COL3A1/COL1A1/MMP2/GNG11/GNGT1/GNG10/GNG5/GNAS/MMP1/GNAI2/SHC3/MAP2K2/GNG2/SHC1/GNB2/TGFB1/HRAS/GRB2/VEGFB/MAPK13/ADCY8/PIK3CD/VEGFC/AKT1/PLCB2/ARRB2	1.96003187696732
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	23/1442	103/9376	1.45192087580626	PLCB1/COL1A2/COL3A1/COL1A1/PRDX1/CD14/IL6/CXCL8/GNAS/CXCL1/RAB5C/LAMA5/IL1B/PRKCB/TGFB1/RAB7B/LAMC2/SERPINB9/ITGAM/FN1/PIK3CD/PLCB2/ARG2	1.96604319898918
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	46/1442	232/9376	1.28920560524176	PFN1/ITGA2/TMSB4X/ARPC1B/CFL1/ARPC3/BRK1/BDKRB1/ARPC2/MYL12A/RAC2/ITGB1/RAC1/MYL12B/MAP2K2/PPP1CA/ITGA11/ITGA3/ARPC5/ACTG1/RDX/ARPC1A/CDC42/FGF10/ACTR3C/PFN2/PDGFC/ACTR2/C6/FGFR4/MYL5/NCKAP1L/FGF7/SSH2/HRAS/VAV1/SCIN/LPAR5/ITGAM/FN1/RAC3/PIK3CD/ARPC5L/AKT1/FGFR3/LIMK2	1.90153691135604
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/1442	31/9376	1.88770077401459	ACAT2/GCSH/MDH2/MDH1/PGP/DLD/GRHPR/ACO1/ACO2	2.11047378962332
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	35/1442	170/9376	1.33866362078812	ARPC1B/ARPC3/TUBA1B/ARPC2/RAB13/MYL12A/RUNX1/MYL6/TUBA4A/ITGB1/RAC1/MYL12B/CCND1/ARPC5/ACTG1/NEDD4L/RDX/ARPC1A/CDC42/ACTR3C/ACTR2/PCNA/CLDN11/MYL6B/CLDN23/TUBA1C/CDK4/WAS/MICALL2/CTTN/PPP2R1A/DLG3/ARPC5L/MAP3K1/RAPGEF6	1.89967668680459
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	14/1442	56/9376	1.625520110957	CD14/IL6/CXCL8/EEF1G/EEF1A1/CR1/PYCARD/HSPA8/VCP/CXCL1/CYCS/IL1B/CASP1/ITGAM	2.00147193536313
Organismal Systems	Digestive system	hsa04970	Salivary secretion	21/1442	93/9376	1.46821171312246	PLCB1/ATP1B1/CALM2/GNAS/ATP1B3/ATP2B1/CALM1/SLC4A2/ITPR2/AQP5/PRKCB/CALM3/GUCY1A1/ATP1A1/PRH1/ADCY8/CALML4/ITPR3/BST1/ITPR1/PLCB2	1.93446886182836
NA	NA	hsa04518	Integrin signaling	32/1442	154/9376	1.35108165066556	COL1A2/COL1A1/ITGA2/SPP1/HGF/RAC2/ITGB1/FRAS1/COL6A1/RAC1/VTN/CCND1/ITGA11/ITGA3/ICAM1/ACTG1/CDC42/CCND2/PDGFC/LAMA5/FREM1/TLN1/TGFB1/VEGFB/LAMC2/ITGAM/FN1/RAC3/PIK3CD/VEGFC/VCAM1/AKT1	1.87274265919444
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/1442	68/9376	1.52990128090071	CD14/RUNX1/MAP2K2/DUSP6/CCND1/EIF4EBP1/FCGR1A/CSF1R/RPS6KB2/SPI1/HRAS/GRB2/ITGAM/PIK3CD/AKT1/BCL2A1	1.86957722411551
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	18/1442	79/9376	1.48148668340385	AP2S1/CLTA/ATP6V1G1/ATP6V0B/ATP6V1F/AP2M1/ATP6V0E1/CLTC/ATP6V0C/SNAP25/ATP6V1A/ATP6V0D1/NAPA/ATP6V1D/ATP6V1E1/ATP6V1B2/DNM1/SYT1	1.83209749421399
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	29/1442	140/9376	1.34685952050723	PLCB1/SPP1/GNG11/RPS6/GNGT1/CALM2/GNG10/GNG5/GNAI2/RYR2/MAP2K2/CALM1/CCND1/GNG2/MEF2C/GNB2/ITPR2/CALM3/RPS6KB2/HRAS/ADCY8/CALML4/ITPR3/PIK3CG/AKT1/ITPR1/PLCB2/TFAM/APLN	1.76277890794999
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	13/1442	53/9376	1.59484992018423	PLCB1/AP2S1/ATP1B1/CLTA/AP2M1/CLTC/GNAS/ATP1B3/ATP2B1/PRKCB/ATP1A1/DNM1/PLCB2	1.85135486072221
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	18/1442	80/9376	1.4629680998613	RPS6/IL6/HGF/SHC3/MAP2K2/SHC1/BAX/EIF4EBP1/PDGFC/PRKCB/EIF4E2/RPS6KB2/HRAS/GRB2/GAS6/PIK3CD/AKT1/FGFR3	1.77284257956442
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	14/1442	59/9376	1.54286654599309	NME2/ENPP1/NME4/NT5C/TYMS/TYMP/NME1/NME3/RRM2B/DUT/DCK/HDDC2/CMPK2/NT5C3B	1.7832129425767
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	17/1442	75/9376	1.47380490060102	PLCB1/ATP1B1/GNAS/ATP1B3/HSPA5/HSP90B1/GPX7/ITPR2/PRKCB/ATP1A1/GSR/PDIA4/ADCY8/GPX8/ITPR3/ITPR1/PLCB2	1.75625481604031
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	29/1442	142/9376	1.32788966810572	CYBA/SQSTM1/FCGR3A/TYROBP/RAC1/IL1A/TNFRSF1A/NCF4/SIRPA/ITPR2/FCGR1A/CSF1R/IL1B/SYK/TGFB1/SPI1/LILRB5/TEC1/TNFRSF11B/FCGR2A/TNFRSF11A/GRB2/MAPK13/ITPR3/PPP3R1/PIK3CD/AKT1/ITPR1/ATP2A2	1.67841417834347
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	11/1442	44/9376	1.625520110957	HLA-C/CPE/HLA-A/HLA-B/PTPRN/IL1A/CD86/CD28/IL1B/ICA1/HLA-F	1.77297421955957
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	15/1442	65/9376	1.50048010242185	PLCB1/SPP1/MAP2K2/ITPR2/PRKCB/HRAS/KCNJ5/ITPR3/PIK3CD/KISS1/AKT1/ITPR1/KCNJ6/PLCB2/ARRB2	1.72610615524842
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	56/1442	300/9376	1.2137216828479	CD14/DUSP4/HGF/RAC2/EFNA5/RAC1/MAP2K2/AREG/DUSP6/MAP4K4/HSPA8/IL1A/MEF2C/TNFRSF1A/CACNG8/BDNF/CDC42/FGF10/CSF1R/PDGFC/IL1B/PRKCB/ARTN/MKNK1/MAP3K2/TGFB1/FGFR4/IRAK1/DUSP10/FGF7/HRAS/CACNA2D4/DUSP9/MAPK7/MAPKAPK3/KITLG/CACNB4/GRB2/VEGFB/MAPK13/PPP5C/PPP3R1/STMN1/RAC3/MAP3K11/VEGFC/EFNA4/RPS6KA1/MAP3K1/AKT1/CDC25B/MAPK8IP2/MAP3K13/ARRB2/FGFR3/ELK1	1.60392530489116
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	9/1442	34/9376	1.7211389410133	POLR2L/POLR2K/POLR2J/POLR2E/POLR2G/POLR2I/POLR2F/POLR2B/POLR2A	1.7958110732905
Organismal Systems	Nervous system	hsa04730	Long-term depression	14/1442	60/9376	1.51715210355987	PLCB1/GNAS/GNAI2/MAP2K2/ITPR2/LYN/GRIA3/PRKCB/GUCY1A1/HRAS/ITPR3/PPP2R1A/ITPR1/PLCB2	1.71317351257186
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	21/1442	99/9376	1.37922918505443	SLC22A3/HIF1A/RAC2/RAC1/MAP2K2/PLD1/DGKI/EIF4EBP1/PLPP2/LYPLA1/PDGFC/PRKCB/RPS6KB2/HRAS/GRB2/WAS/CHKB/RAC3/PIK3CD/AKT1/SLC22A4	1.61710322075958
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	66/1442	362/9376	1.18546218036643	COL1A2/COL1A1/ITGA2/SPP1/GNG11/RPS6/GNGT1/IL6/GNG10/GNG5/DDIT4/HGF/CDK6/ITGB1/EFNA5/YWHAB/COL6A1/RAC1/MAP2K2/AREG/VTN/CCND1/ITGA11/HSP90B1/GNG2/ITGA3/GNB2/EIF4EBP1/BDNF/CCND2/FGF10/CSF1R/PDGFC/LAMA5/SYK/ARTN/EIF4E2/RPS6KB2/FGFR4/MTCP1/CDC37/PIK3AP1/FGF7/HRAS/GYS1/G6PC3/KITLG/PRL/CDK4/GRB2/VEGFB/LAMC2/LPAR5/JAK3/EPOR/PIK3CG/FN1/PIK3CD/PPP2R1A/CSH1/VEGFC/EFNA4/LPAR6/AKT1/MLST8/FGFR3	1.53416842403734
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	17/1442	77/9376	1.43552425383216	RAC2/CDK6/RAC1/CDKN2A/CCND1/PLD1/BAX/CDC42/RALA/RPS6KB2/TGFB1/RB1/CDK4/RAC3/PIK3CD/AKT1/E2F3	1.63591884167893
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	22/1442	105/9376	1.36234066442111	RPS27A/GABARAP/HIF1A/UBA52/UBB/SQSTM1/TOMM7/GABARAPL2/FIS1/CSNK2B/VCP/RAB5C/TOMM20/FKBP8/HRAS/RAB7B/ATG9A/TBC1D17/TOMM40/SAMM50/PHB2/CSNK2A1	1.59173441274364
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	22/1442	105/9376	1.36234066442111	IL6/CALM2/FCER1G/PYCARD/CALM1/ITPR2/IKBKE/IL1B/SYK/CALM3/LSP1/CD209/CASP1/CLEC7A/HRAS/MAPK13/CALML4/ITPR3/PPP3R1/PIK3CD/AKT1/ITPR1	1.59173441274364
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	28/1442	139/9376	1.30977160019557	PLCB1/CTSD/MMP2/CALM2/GNAS/GNAI2/SHC3/MAP2K2/CALM1/HSP90B1/HSPA8/SHC1/ITPR2/KRT19/KRT10/CALM3/HRAS/GRB2/KCNJ5/ADCY8/CALML4/ITPR3/FKBP4/PIK3CD/AKT1/ITPR1/KCNJ6/PLCB2	1.56857647691836
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	9/1442	35/9376	1.67196354269863	AKR1B1/TPI1/PFKFB4/ENOSF1/PFKP/HK2/AKR1B10/TIGAR/HSD17B14	1.69787306032349
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	39/1442	205/9376	1.23698115760631	HLA-C/PKM/HLA-A/HLA-B/CDK6/YWHAB/RAC1/CDKN2A/CCND1/VAC14/GTF2A2/BAX/HNRNPK/CDC42/CCND2/HDAC8/LYN/SP100/ATP6V0D1/HDAC9/SYK/SND1/HRAS/RB1/RANBP1/HDAC2/CDK4/GRB2/HDAC3/SCIN/JAK3/PMAIP1/SKP2/TBPL1/PIK3CD/HDAC1/DDB1/HLA-F/PSMC1	1.4625292842115
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/1442	31/9376	1.67795624356852	G6PD/TKT/GPI/PGD/TALDO1/PGLS/PFKP/PGM1	1.6118143911175
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	12/1442	52/9376	1.50048010242185	ANGPTL4/NPC2/TSPO/PLTP/CD36/VDAC2/VDAC1/LRP1/STARD3NL/LRPAP1/APOE/LIPG	1.54279962856715
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	37/1442	195/9376	1.23372808421352	PLCB1/CYBA/SLC25A6/FCGR3A/CYBB/RAC2/SLC25A5/CR1/RAC1/MAP2K2/VDAC2/NCF4/ACTG1/FCGR1A/HDAC8/VDAC1/CLCN5/PRKCB/ATG7/HDAC9/SYK/CASP1/CLEC7A/FPR1/FCGR2A/HDAC2/TLR7/MAPK13/HDAC3/SLC25A4/ITGAM/PIK3CD/HDAC1/AKT1/PLCB2/CLCN3/SIGLEC9	1.40606494751109
Organismal Systems	Endocrine system	hsa04924	Renin secretion	15/1442	69/9376	1.41349574865826	PLCB1/CALM2/GNAS/GNAI2/CTSB/CALM1/ITPR2/ORAI1/CALM3/GUCY1A1/CALML4/ITPR3/PPP3R1/ITPR1/PLCB2	1.46964657700878
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	27/1442	137/9376	1.28143191228727	CTSD/TUBA1B/TUBA4A/CTSB/MAP2K2/CTSC/TNFRSF1A/BAX/BID/CTSL/ACTG1/ITPR2/CYCS/CTSZ/ATM/TUBA1C/HRAS/ENDOG/NOL3/TNFRSF10B/ITPR3/PMAIP1/PIK3CD/AKT1/ITPR1/BCL2A1/CAPN1	1.41463145958151
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	60/1442	333/9376	1.17154602591496	HLA-C/COL1A2/COL1A1/ITGA2/PKM/ATP6V1G1/ATP6V0B/ATP6V1F/SPP1/HLA-A/ATP6V0E1/HLA-B/GNAS/ATP6V0C/WNT2/CDK6/ITGB1/COL6A1/MAP2K2/VTN/CCND1/ITGA11/ITGA3/TNFRSF1A/ATP6AP1/BAX/ATP6V1A/EIF4EBP1/CDC42/CCND2/FZD4/IKBKE/ATP6V0D1/FZD2/LAMA5/BCAP31/FZD7/ATP6V1D/RPS6KB2/ATP6V1E1/ATM/HRAS/RB1/HDAC2/CDK4/GRB2/TUBG1/LAMC2/ATP6V1B2/FN1/TBPL1/PIK3CD/HDAC1/PPP2R1A/DLG3/AKT1/HLA-F/PSMC1/DVL3/WNT10A	1.35884112799356
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	35/1442	184/9376	1.23680878007598	NRP1/CFL1/MYL12A/GNAI2/RAC2/ITGB1/EFNA5/SLIT3/RAC1/MYL12B/ROBO2/EPHA3/ROBO1/CDC42/EPHA5/SEMA4B/BMP7/EFNB2/MYL5/SSH2/HRAS/NTNG1/UNC5B/PLXNB2/LRRC4/EPHB2/PPP3R1/RAC3/PIK3CD/SEMA3G/EFNA4/RHOD/CDK5/LIMK2/PLXNA3	1.38300539582113
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	16/1442	75/9376	1.38711049468331	GSTP1/GSTO1/GSTM3/CDKN2A/MGST3/BAX/BID/MGST1/CYCS/GSTT2B/MGST2/ATM/PMAIP1/PIK3CD/TOP2A/AKT1	1.43490426073033
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	8/1442	32/9376	1.625520110957	GABARAP/GABARAPL2/ATG7/WIPI2/ATG9A/ATG4D/MLST8/ATG3	1.51102629404275
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1442	27/9376	1.68572455951097	FADS1/SCD/ELOVL2/FADS2/TECR/HACD4/ACAA1	1.52114696999938
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	38/1442	203/9376	1.21713821115992	COL1A2/COL1A1/ITGA2/SPP1/MYL12A/HGF/RAC2/ITGB1/COL6A1/RAC1/MYL12B/SHC3/PPP1CA/VTN/CCND1/ITGA11/ITGA3/SHC1/ACTG1/CDC42/CCND2/PDGFC/LAMA5/PRKCB/TLN1/ARHGAP5/MYL5/HRAS/VAV1/GRB2/VEGFB/LAMC2/FN1/RAC3/PIK3CD/VEGFC/AKT1/ELK1	1.33337021080176
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	26/1442	133/9376	1.27108339503405	HLA-C/HLA-A/FCGR3A/HLA-B/HCST/FCER1G/RAC2/TYROBP/RAC1/SHC3/MAP2K2/SHC1/ICAM1/BID/SH3BP2/PRKCB/SYK/HRAS/VAV1/TNFRSF10B/GRB2/MICA/PPP3R1/RAC3/PIK3CD/PTPN6	1.34228405233953
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	19/1442	93/9376	1.32838202615841	MYL12A/RAC2/RAC1/MYL12B/HEG1/CSNK2B/ACTG1/CDC42/PTPRJ/LMO7/MYL5/ACP1/WAS/RAC3/SNAI2/PDCD10/PTPN6/CCM2/CSNK2A1	1.35674693003977
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	23/1442	116/9376	1.28920560524176	PLCB1/GNG11/GNGT1/GNG10/GNG5/GNAS/GNAI2/GRIA4/HOMER3/GNG2/PLD1/GNB2/ITPR2/GRIA3/PRKCB/GRIN2C/ADCY8/SHANK1/ITPR3/PPP3R1/NCDN/ITPR1/PLCB2	1.33614126732404
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	9/1442	38/9376	1.53996642090664	GPI/HEXA/UAP1L1/HK2/GALE/PGM1/GALK2/GNPDA1/AMDHD2	1.42185001486377
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	32/1442	169/9376	1.23116316096152	RPS27A/GABARAP/HIF1A/CTSD/VAMP8/UBA52/UBB/SQSTM1/DDIT4/GABARAPL2/CTSB/MAP2K2/LAMP1/SH3GLB1/CTSL/LAMP2/ATG7/WIPI2/RPS6KB2/RRAGA/HRAS/AKT1S1/RAB7B/ATG9A/VPS18/PIK3CD/AKT1/ITPR1/ATG4D/MLST8/EIF2AK4/ATG3	1.29278134187126
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	8/1442	33/9376	1.57626192577649	BCAT1/IDH1/IDH2/PDHB/DLD/GPT2/ACO1/ACO2	1.41369555371657
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	20/1442	100/9376	1.3004160887656	CXCL14/CCL2/IL6/CXCL8/CCL3/CCL4L2/CCL4/TNFRSF1A/CXCL1/CXCL6/CCL3L1/CCR1/CSF1R/CXCL5/IL24/TNFRSF10B/CX3CR1/CCL28/CCL8/IL10RA	1.28755262292194
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/1442	28/9376	1.625520110957	ELOVL2/HADHB/HADHA/TECR/ACAA2/ECHS1/HACD4	1.41313323745532
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	7/1442	28/9376	1.625520110957	AKR1B1/CBR1/GGH/PTS/MOCS2/AKR1B10/AKR1C3	1.41313323745532
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	29/1442	154/9376	1.22441774591567	PLCB1/ATP1B1/CALM2/SCN1B/GNAS/GNAI2/ATP1B3/RYR2/ATP2B1/CALM1/PPP1CA/POPDC3/TPM3/TPM2/CACNG8/CALM3/CREM/ATP1A1/CACNA2D4/CACNB4/MAPK13/ADCY8/KCNQ1/CALML4/PIK3CG/PPP2R1A/AKT1/PLCB2/ATP2A2	1.19709100563868
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	24/1442	125/9376	1.24839944521498	PLCB1/CTSD/FCER1G/ASAH1/GNAI2/RAC2/RAC1/MAP2K2/TNFRSF1A/PLD1/BAX/BID/DEGS1/PRKCB/ORMDL1/CERS2/SMPD1/HRAS/MAPK13/RAC3/PIK3CD/PPP2R1A/AKT1/PLCB2	1.19188254022818
Human Diseases	Cancer: specific types	hsa05218	Melanoma	15/1442	73/9376	1.33604392681398	HGF/CDK6/MAP2K2/CDKN2A/CCND1/BAX/FGF10/PDGFC/FGF7/HRAS/RB1/CDK4/PIK3CD/AKT1/E2F3	1.22876304327105
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	20/1442	102/9376	1.27491773408392	PLCB1/RAB27B/ATP1B1/GNAS/ATP1B3/RYR2/ATP2B1/RAC1/SLC4A2/ITPR2/PRSS3/PRKCB/ATP1A1/ADCY8/KCNQ1/ITPR3/BST1/ITPR1/PLCB2/ATP2A2	1.19012195267945
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	23/1442	120/9376	1.24623208506704	BEX3/CALM2/RAC1/SHC3/MAP2K2/CALM1/SHC1/BAX/BDNF/CDC42/CALM3/MAGED1/IRAK1/HRAS/MAPK7/GRB2/MAPK13/CALML4/SH2B3/PIK3CD/RPS6KA1/MAP3K1/AKT1	1.15729949346583
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/1442	19/9376	1.71107380100737	HEXA/GLB1/ARSB/NAGLU/HYAL2	1.32265121049085
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	20/1442	103/9376	1.26253989200544	DPP4/COL1A2/COL3A1/COL1A1/ATP1B1/COL5A2/ATP1B3/SLC16A10/COL6A1/COL8A2/COL14A1/SLC3A2/COL15A1/PRSS3/COL7A1/ATP1A1/COL21A1/KCNQ1/COL22A1/SLC7A7	1.14215739252978
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	20/1442	103/9376	1.26253989200544	PLCB1/CCL2/CALR/IL6/CXCL8/CCL3/GNAS/GNAI2/C1QA/TNFRSF1A/C1QC/CCL3L1/IL1B/TGFB1/IRAK1/MAPK13/PIK3CD/PPP2R1A/AKT1/PLCB2	1.14215739252978
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	21/1442	109/9376	1.25269439743476	CD14/SPP1/IL6/CXCL8/CCL3/RAC1/MAP2K2/CCL4L2/CCL4/CD86/CCL3L1/IKBKE/LY96/IL1B/TLR1/IRAK1/CD40/TLR7/MAPK13/PIK3CD/AKT1	1.13125744641419
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	14/1442	69/9376	1.31926269874771	FCER1G/RAC2/RAC1/MAP2K2/LYN/SYK/HRAS/VAV1/ALOX5AP/GRB2/MAPK13/RAC3/PIK3CD/AKT1	1.13472347395024
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	19/1442	98/9376	1.26060743298706	PLCB1/ATP1B1/CALM2/GNAS/ATP1B3/ATP2B1/CALM1/ITPR2/ORAI1/PRKCB/CALM3/ATP1A1/HSD3B2/KCNJ5/ADCY8/CALML4/ITPR3/ITPR1/PLCB2	1.10559183445005
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/1442	30/9376	1.51715210355987	IL6/FOLR2/ABCC3/IL1B/GGH/TYMS/MTHFR	1.20945079657177
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	21/1442	110/9376	1.24130626654899	GREM1/BAMBI/BMP5/PITX2/ID1/EMP3/ID3/BMP4/RBX1/SKP1/ID2/BMP7/RPS6KB2/TGFB1/SMAD6/HDAC2/GREM2/ACVR2A/GDF6/HDAC1/PPP2R1A	1.08527791491729
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	24/1442	128/9376	1.21914008321775	NME2/PDE7B/GUK1/LACC1/APRT/AK1/PDE4D/AK4/DGUOK/ENPP1/NME4/NT5C/GUCY1A1/AK6/NME1/ADCY8/NUDT5/PGM1/NME3/RRM2B/DCK/AK3/HDDC2/GMPR	1.06420444077776
Cellular Processes	Cell motility	hsa04814	Motor proteins	35/1442	194/9376	1.17305575017516	TUBA1B/MYL12A/DYNLL1/DYNLT1/MYL6/TUBA4A/TUBB/KIF26B/CAPZB/MYL12B/MYO1B/ACTG1/TPM3/TPM2/TNNT1/DYNLRB1/DNAH8/TUBB3/DNAH14/CAPZA2/DCTN3/MYO5B/MYL6B/MYL5/TUBA1C/KIF5B/TNNT3/TUBG1/MYO5A/DCTN4/DCTN6/ACTR10/KIF20B/KLC2/DNALI1	1.03834201000549
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	18/1442	93/9376	1.25846718267639	ITGA2/CDK6/ITGB1/CCND1/ITGA3/RARB/BAX/CYCS/LAMA5/RB1/CDK4/LAMC2/CKS2/SKP2/FN1/PIK3CD/AKT1/E2F3	1.06788596414548
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	52/1442	298/9376	1.1345912183861	CXCL14/IL33/BMP5/CCL2/IL6/CXCL8/GDF15/CCL3/TNFRSF21/TNFRSF12A/IL11/CCL4L2/BMP4/CCL4/IL1A/IL12RB2/TNFRSF1A/CXCL1/CXCL6/CCL3L1/CCR1/TNFSF9/TNFSF13B/CSF1R/TNFSF12/CXCL5/EDA/IL1B/BMP7/IL24/LIF/TGFB1/TNFRSF11B/CD40/TNFRSF11A/CD4/PRL/TNFRSF10B/IL13RA1/RELL2/EPOR/CX3CR1/ACVR2A/CTF1/GDF6/CCL28/IL1RN/TNFRSF25/CSH1/CCL8/IL10RA/CNTFR	1.00658843824542
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	19/1442	99/9376	1.24787402457305	MMP2/GNAS/SHC3/MAP2K2/CDKN2A/CCND1/SHC1/BAX/RPS6KB2/HRAS/RB1/CDK4/GRB2/MAPK13/ADCY8/PIK3CD/CDKN2C/AKT1/E2F3	1.05698057870255
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	19/1442	99/9376	1.24787402457305	PLCB1/CALM2/BDKRB1/GNAS/CALM1/PPP1CA/ITPR2/IL1B/PRKCB/CALM3/MAPK13/TRPA1/ADCY8/CALML4/ITPR3/PIK3CD/ITPR1/ASIC1/PLCB2	1.05698057870255
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	36/1442	201/9376	1.16455172128263	HMGA2/CD14/IL6/CXCL8/RUNX1/NUPR1/PROM1/DUSP6/MEF2C/BMP2K/BAX/FCGR1A/ID2/CCND2/CD86/RUNX2/CSF1R/GRIA3/ETV5/SPI1/FLI1/ATM/CD40/HDAC2/FUT8/PLAU/ITGAM/LDB1/HDAC1/CDKN2C/LMO2/BCL2A1/SPINT1/NR4A3/EYA1/ETV1	1.00535534714961
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	15/1442	76/9376	1.28330535075553	ANGPTL4/ME1/SCD/DBI/MMP1/PLIN2/PLTP/CD36/FADS2/HMGCS1/GK/CPT1C/SLC27A4/ACAA1/CPT2	1.05716376566885
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	42/1442	238/9376	1.14742596067553	GNG11/GNGT1/CALM2/GNG10/GNG5/HGF/RAC2/EFNA5/RAC1/SHC3/MAP2K2/CALM1/HTR7/GNG2/SHC1/PLD1/GNB2/RAB5C/BDNF/CDC42/FGF10/RGL1/CSF1R/PDGFC/PRKCB/CALM3/RALA/FGFR4/FGF7/HRAS/KITLG/GRB2/VEGFB/SYNGAP1/CALML4/RAC3/PIK3CD/VEGFC/EFNA4/AKT1/FGFR3/ELK1	0.982107524533538
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	10/1442	48/9376	1.35460009246417	PLCB1/ATP1B1/ATP1B3/PRKCB/HK2/ATP1A1/G6PC3/PIK3CD/AKT1/PLCB2	1.04999532352901
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	17/1442	89/9376	1.24197042185479	COL1A2/COL1A1/ITGA2/SPP1/ITGB1/FRAS1/COL6A1/CD36/VTN/ITGA11/ITGA3/LAMA5/FREM1/CD47/SV2A/LAMC2/FN1	0.977781312058568
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	19/1442	101/9376	1.22316364784883	PLCB1/CALM2/GNAS/WNT2/GNAI2/MAP2K2/CALM1/FZD4/FZD2/PRKCB/CALM3/FZD7/HRAS/KITLG/ADCY8/CALML4/PLCB2/DVL3/WNT10A	0.961278767614552
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/1442	60/9376	1.3004160887656	RAC2/RAC1/MAP2K2/CDC42/PRKCB/HRAS/MAPKAPK3/MAPK13/PPP3R1/RAC3/PIK3CD/AKT1	0.995190549319862
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	27/1442	149/9376	1.17822934217018	PLCB1/CXCL8/GNAS/FCER1G/SHC3/MAP2K2/SHC1/PLD1/DGKI/PLPP2/CYTH4/PDGFC/SYK/AGPAT2/RALA/HRAS/PTGFR/KITLG/GRB2/ADCY8/LPAR5/DNM1/PIK3CG/PIK3CD/LPAR6/AKT1/PLCB2	0.934898038035625
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	7/1442	32/9376	1.42233009708738	LDHB/LDHA/HADHA/ACACA/ECHS1/DLD/ECHDC1	1.02019402779605
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	25/1442	138/9376	1.17791312388189	RPS6/CALM2/SHC3/MAP2K2/CALM1/PPP1CA/SHC1/EIF4EBP1/CALM3/HK2/MKNK1/EIF4E2/RPS6KB2/HRAS/GYS1/ACACA/G6PC3/FASN/PRKAR1A/GRB2/CALML4/PIK3CD/AKT1/PHKG2/ELK1	0.897595610018168
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	11/1442	55/9376	1.3004160887656	ASAH1/PSAP/HEXA/NEU1/PLPP2/DEGS1/CERS2/SMPD1/GLB1/GLA/B4GALT6	0.952566817030922
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	15/1442	79/9376	1.23457223616988	CYP1B1/GSTP1/GSTO1/HPGDS/GSTM3/CBR1/AKR1C1/MGST3/MGST1/CYP1A2/GSTT2B/ADH5/MGST2/EPHX1/AKR7A2	0.892567169378051
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	6/1442	27/9376	1.44490676529511	ACAT2/HMGCLL1/HMGCS1/HADHA/ECHS1/BDH1	0.986939389254974
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	17/1442	91/9376	1.21467436862721	RAC2/RAC1/MAP2K2/LYN/PRKCB/SYK/LILRB5/PIK3AP1/HRAS/VAV1/GRB2/CARD11/PPP3R1/RAC3/PIK3CD/AKT1/PTPN6	0.877267633952408
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	21/1442	115/9376	1.18733642887294	PLCB1/GNG11/GNGT1/GNG10/GNG5/GNAI2/GNG2/GNB2/ITPR2/PRKCB/HRAS/ADCY8/KCNQ1/ITPR3/PIK3CG/KCNJ12/PIK3CD/AKT1/ITPR1/KCNJ6/PLCB2	0.861716453868117
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	9/1442	45/9376	1.3004160887656	HLA-C/HLA-A/IL6/HLA-B/IL1A/CD86/CD28/IL1B/HLA-F	0.861167279195541
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	29/1442	166/9376	1.13590561970489	PLCB1/ATP1B1/SLC25A6/CALM2/GNAI2/ATP1B3/SLC25A5/ATP2B1/MAP2K2/CALM1/PPP1CA/MEF2C/VDAC2/ITPR2/VDAC1/CALM3/GUCY1A1/ATP1A1/GTF2I/ADCY8/CALML4/SLC25A4/ITPR3/PIK3CG/PPP3R1/AKT1/ITPR1/PLCB2/ATP2A2	0.753154047647412
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	12/1442	63/9376	1.2384915131101	SMYD3/ACAT2/PRDM6/PLOD2/ALDH2/HADHA/ECHS1/DLD/ALDH3A2/PLOD1/ALDH9A1/KMT5A	0.80969335020307
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	13/1442	69/9376	1.22502964883716	CALM2/GNAS/GRIA4/CALM1/PPP1CA/GRIA3/PRKCB/CALM3/HDAC2/GRIN2C/CALML4/PPP3R1/HDAC1	0.799800370891704
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	16/1442	87/9376	1.19578490920975	RAC2/RAC1/MAP2K2/AREG/CCND1/BAX/CYCS/RALA/RPS6KB2/TGFB1/HRAS/GRB2/PMAIP1/RAC3/PIK3CD/AKT1	0.782125650550421
Human Diseases	Infectious disease: viral	hsa05162	Measles	24/1442	136/9376	1.14742596067553	RACK1/IL6/CDK6/CCND1/HSPA8/IL1A/CSNK2B/BAX/BID/CCND2/IKBKE/CD28/CYCS/IL1B/RAB9A/CD209/IRAK1/EIF3H/CDK4/TLR7/JAK3/PIK3CD/AKT1/CSNK2A1	0.738294452820664
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	30/1442	173/9376	1.12752840066382	IL33/CCL2/SLC25A6/IL6/CXCL8/FDPS/CDK6/SLC25A5/PYCARD/MAP2K2/IL1A/TNFRSF1A/BAX/ICAM1/BID/ACTG1/VDAC1/IKBKE/PRSS3/CYCS/IL1B/PRKCB/CASP1/TNFRSF10B/CDK4/TLR7/XPO1/SLC25A4/PIK3CD/AKT1	0.72175104956153
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	9/1442	46/9376	1.27214617379244	FTH1/FTL/HMOX1/BLVRB/MMAB/UROS/BLVRA/ALAS1/UROD	0.788791999585365
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	18/1442	100/9376	1.17037447988904	ITGA2/CD14/IL6/CD9/CR1/IL11/CD36/IL1A/ITGA3/FCGR1A/CSF1R/IL1B/CD7/CD4/KITLG/CD33/EPOR/ITGAM	0.730207590949821
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	16/1442	88/9376	1.18219644433237	F13A1/SERPINB2/BDKRB1/PLAUR/CFB/CR1/C1QA/VTN/C1QC/C3AR1/C4BPB/C6/PROCR/PROS1/PLAU/ITGAM	0.732052621593395
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	15/1442	82/9376	1.18940495923683	HLA-C/B2M/LGMN/CALR/PDIA3/HLA-A/HLA-B/HSPA5/CTSB/HSPA8/CTSL/TAPBP/PSME2/CD4/HLA-F	0.734377070663949
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	13/1442	70/9376	1.20752922528235	CYP1B1/GSTP1/GSTO1/HPGDS/GSTM3/CBR1/MGST3/SULT1A1/MGST1/CYP1A2/GSTT2B/MGST2/EPHX1	0.742965985047235
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/1442	70/9376	1.20752922528235	HIF1A/ELOB/HGF/RAC1/MAP2K2/RBX1/ELOC/CDC42/TGFB1/HRAS/GRB2/PIK3CD/AKT1	0.742965985047235
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	25/1442	144/9376	1.12883341038681	CD14/SCD/IL6/CXCL8/C1QA/CCND1/TNFRSF1A/C1QC/CXCL1/ALDH2/IKBKE/LY96/C3AR1/IL1B/ACADVL/ADIPOR1/ADH5/IRAK1/ACACA/FASN/CPT1C/MAPK13/ALDH3A2/AKT1/ALDH9A1	0.66417728987701
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	20/1442	115/9376	1.13079659892661	PLCB1/GNG11/GNGT1/GNG10/GNG5/GNAS/GNAI2/HTR7/GNG2/GNB2/ITPR2/PRKCB/PTGS1/HRAS/APP/KCNJ5/ITPR3/ITPR1/KCNJ6/PLCB2	0.601642628095006
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	7/1442	36/9376	1.26429341963323	GPI/ENPP1/HK2/GYS1/G6PC3/PGM1/GYG1	0.677308198875425
NA	NA	hsa03272	Virion - Hepatitis viruses	9/1442	48/9376	1.21914008321775	DPP4/CD63/CD9/LAMP1/LAMP2/TGOLN2/CLDN11/CLDN23/CHMP1B	0.648888896157434
Human Diseases	Substance dependence	hsa05032	Morphine addiction	16/1442	91/9376	1.14322293517855	PDE7B/GNG11/GNGT1/GNG10/GNG5/GNAS/GNAI2/PDE4D/GNG2/GNB2/PRKCB/GABRE/KCNJ5/ADCY8/KCNJ6/ARRB2	0.585281076056143
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	21/1442	122/9376	1.1192105681999	SCD/PFKFB4/CD36/CCND1/EIF4EBP1/PFKP/EEF2/RAB10/ADIPOR1/RPS6KB2/GYS1/HMGCR/AKT1S1/ACACA/G6PC3/FASN/CPT1C/PIK3CD/PPP2R1A/STRADB/AKT1	0.565004746239008
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	21/1442	122/9376	1.1192105681999	PLCB1/ATP1B1/HIF1A/ATP1B3/SLC16A10/MAP2K2/BMP4/CCND1/ACTG1/PFKP/PRKCB/ATP1A1/HRAS/HDAC2/HDAC3/PIK3CD/HDAC1/AKT1/PLCB2/ATP2A2/PLCD4	0.565004746239008
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1442	13/9376	1.50048010242185	XRCC5/XRCC6/PRKDC	0.769791569797314
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	42/1442	254/9376	1.07514716000306	PLCB1/SLC25A6/CALM2/BDKRB1/ASPH/GNAS/RYR2/HGF/SLC25A5/ATP2B1/CALM1/HTR7/VDAC2/ITPR2/ORAI1/HRH2/VDAC1/FGF10/PDGFC/PRKCB/CALM3/FGFR4/MCOLN2/FGF7/PTGFR/GRIN2C/VEGFB/ADORA2B/ADCY8/CYSLTR1/CALML4/SLC25A4/ITPR3/PTAFR/PPP3R1/VEGFC/ITPR1/PHKG2/PLCB2/ATP2A2/FGFR3/PLCD4	0.517614658604598
Organismal Systems	Digestive system	hsa04978	Mineral absorption	11/1442	61/9376	1.17250630954276	FTH1/FTL/ATP1B1/ATOX1/MT2A/ATP1B3/ATP2B1/HMOX1/SLC40A1/STEAP1/ATP1A1	0.576236338959687
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	9/1442	49/9376	1.19425967335617	GALNT1/GXYLT2/ST6GAL1/GALNT9/C1GALT1/GALNT12/B4GALT2/B3GLCT/POGLUT1	0.581208391597962
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	7/1442	37/9376	1.23012332721071	GPI/UAP1L1/HK2/GALE/CMAS/PGM1/GALK2	0.597906795271049
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1442	37/9376	1.23012332721071	PLCB1/IL6/ICAM1/IL1B/PRKCB/VCAM1/PLCB2	0.597906795271049
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/1442	37/9376	1.23012332721071	MAP2K2/CCND1/NCOA4/BAX/TPM3/HRAS/TFG	0.597906795271049
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/1442	31/9376	1.25846718267639	ALDH2/SMOX/HADHA/ECHS1/ALDH3A2/ALDH9A1	0.614495594105838
NA	NA	hsa04981	Folate transport and metabolism	6/1442	31/9376	1.25846718267639	FOLR2/ABCC3/SLCO2B1/TYMS/MTHFR/MTHFS	0.614495594105838
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	15/1442	86/9376	1.1340837983421	ITGA2/CDH2/RYR2/ITGB1/DSG2/ITGA11/ITGA3/ACTG1/CACNG8/DSC2/SNTA1/SGCA/CACNA2D4/CACNB4/ATP2A2	0.532524806398091
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	7/1442	38/9376	1.19775166070516	QPRT/NAMPT/ENPP1/NT5C/NMRK1/BST1/NAPRT	0.52072349469595
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1442	14/9376	1.39330295224886	CHST1/FUT8/B4GALT2	0.627811224560115
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	14/1442	82/9376	1.11011129528771	NME2/GSTP1/GSTO1/GSTM3/MGST3/MGST1/GSTT2B/NME4/MGST2/TYMP/NME1/NME3/RRM2B/DUT	0.426932910343124
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	26/1442	158/9376	1.06996260468056	CDK6/YWHAB/ANAPC11/CDKN2A/RBX1/SKP1/CCND1/CCND2/HDAC8/PCNA/TGFB1/ATM/RB1/HDAC2/CDK4/ANAPC16/SKP2/PRKDC/CCNB2/HDAC1/PPP2R1A/CDKN2C/CDC25B/E2F3/ANAPC10/CDC14B	0.378092734211142
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/1442	39/9376	1.16704007966144	HLA-C/HLA-A/HLA-B/CD86/CD28/CD40/HLA-F	0.445626986178871
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	18/1442	108/9376	1.08368007397134	SUMO2/EEF1A1/RAN/SAP18/SUMO1/RBM8A/TNPO1/KPNB1/ALYREF/UBE2I/UPF3A/SRRM1/XPO1/THOC3/XPOT/KPNA3/MAGOH/IPO13	0.372874849377391
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	12/1442	71/9376	1.09894317360474	SHC3/MAP2K2/CCND1/SHC1/CCND2/HRAS/TNFRSF11A/PRL/GRB2/MAPK13/PIK3CD/AKT1	0.356762330480858
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	15/1442	90/9376	1.08368007397134	HIF1A/MAP2K2/CSNK2B/CD28/RPS6KB2/EML4/HRAS/CD4/MAPK13/BATF/PPP3R1/PIK3CD/AKT1/PTPN6/CSNK2A1	0.340056547165739
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1442	15/9376	1.3004160887656	AK1/AK4/ACP1	0.496397819122755
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	26/1442	160/9376	1.05658807212205	HLA-C/CDH2/CADM3/HLA-A/HLA-B/ITGB1/CD99/ICAM1/PTPRD/CD86/SLITRK4/CD28/PTPRC/CLDN11/SIGLEC1/CLDN23/GLG1/CD40/NTNG1/CD4/LRRC4/ITGAM/CNTNAP1/VCAM1/PTPRS/HLA-F	0.307776762486992
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	25/1442	155/9376	1.04872265223033	PLCB1/GNAS/WNT2/GNAI2/CDK6/MAP2K2/CDKN2A/CCND1/ITPR2/ORAI1/FZD4/FZD2/FZD7/HSD3B2/RB1/CDK4/ADCY8/ITPR3/ASH2L/CDKN2C/E2F3/ITPR1/PLCB2/DVL3/WNT10A	0.260753369761503
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/1442	41/9376	1.11011129528771	PGAM1/GCSH/PHGDH/DLD/ALAS1/GRHPR/GATM	0.301223471285518
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	17/1442	105/9376	1.05271778614358	ITGA2/GNAS/RYR2/ITGB1/ITGA11/ITGA3/ACTG1/TPM3/TPM2/CACNG8/SNTA1/TGFB1/SGCA/CACNA2D4/CACNB4/ADCY8/ATP2A2	0.231585142403115
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	16/1442	99/9376	1.05084128385099	ITGA2/IL6/RYR2/ITGB1/ITGA11/ITGA3/ACTG1/TPM3/TPM2/CACNG8/SNTA1/TGFB1/SGCA/CACNA2D4/CACNB4/ATP2A2	0.216796615616998
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	23/1442	144/9376	1.03852673755586	WNT2/ID1/MAP2K2/ID3/BMP4/ID2/FZD4/JARID2/FZD2/LIF/FZD7/FGFR4/HRAS/DUSP9/GRB2/MAPK13/JAK3/ACVR2A/PIK3CD/AKT1/FGFR3/DVL3/WNT10A	0.198617610609154
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	22/1442	138/9376	1.03656354901606	CALM2/YWHAB/ANAPC11/CALM1/PPP1CA/RBX1/SKP1/ITPR2/CALM3/ANAPC16/MAPK13/ADCY8/CALML4/ITPR3/PPP3R1/CCNB2/PPP2R1A/CPEB1/RPS6KA1/ITPR1/AURKA/ANAPC10	0.184468016565704
Organismal Systems	Sensory system	hsa04744	Phototransduction	5/1442	29/9376	1.12104835238414	GNGT1/CALM2/CALM1/CALM3/CALML4	0.278319689010614
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1442	23/9376	1.13079659892661	ASL/GPT2/ASS1/ARG2	0.267736186014393
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/1442	23/9376	1.13079659892661	SSBP1/PCNA/POLD4/MLH3	0.267736186014393
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1442	23/9376	1.13079659892661	ATP1B1/ATP1B3/MDH1/ATP1A1	0.267736186014393
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	10/1442	62/9376	1.04872265223033	HSPA8/SOD1/RPS6KB2/HRAS/AKT1S1/HDAC2/ADCY8/PIK3CD/HDAC1/AKT1	0.164089510506139
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1442	17/9376	1.14742596067553	INMT/TXNRD1/SEPHS2	0.25936171774695
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	28/1442	180/9376	1.01143473570658	HLA-C/B2M/CCL2/CALR/PDIA3/HLA-A/IL6/HLA-B/SRSF9/PPP1CA/POU2F2/TNFRSF1A/BAX/BID/EIF4EBP1/IKBKE/SP100/BST2/CYCS/IL1B/SYK/TAPBP/ALYREF/IRAK1/SRSF2/PIK3CD/AKT1/HLA-F	0.0660366559373178
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	18/1442	115/9376	1.01771693903395	PLCB1/NACA/GNAS/GNAI2/PDE4D/MMP14/MEF2C/PLD1/ITPR2/RUNX2/MMP16/PRKCB/ADCY8/ITPR3/MMP15/ITPR1/PLCB2/ARRB2	0.0814949765487841
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	14/1442	89/9376	1.02279917093924	GABARAP/GNG11/GNGT1/GNG10/GNG5/GNAI2/GABARAPL2/GNG2/GNB2/PRKCB/GABRE/ADCY8/SLC12A5/KCNJ6	0.0921294557571769
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	10/1442	63/9376	1.03207626092508	PTGDS/GPX4/HPGDS/CBR1/LTC4S/PTGIS/PTGR1/PTGS1/TBXAS1/AKR1C3	0.108900877988173
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	19/1442	122/9376	1.0126190855142	PLCB1/GNAS/GNAI2/SHC3/MAP2K2/SHC1/ITPR2/PRKCB/HRAS/GRB2/MAPK13/ADCY8/ITPR3/PIK3CD/CSH1/MAP3K1/AKT1/ITPR1/PLCB2	0.0598088182648579
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	13/1442	83/9376	1.01839814180439	PRDX1/PRDX5/SOD1/HMGCLL1/IDH1/IDH2/MVK/ECH1/PEX2/NUDT7/ECI2/ACAA1/CRAT	0.0717723571883928
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	13/1442	83/9376	1.01839814180439	IL33/IL6/POLR2L/PYCARD/CCL4L2/CCL4/POLR2K/IKBKE/IL1B/POLR2E/CASP1/IFI16/POLR2F	0.0717723571883928
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/1442	31/9376	1.04872265223033	AKR1A1/ALDH2/ALDH3A2/HSD17B14/ALDH9A1	0.11583619560001
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1442	18/9376	1.08368007397134	PRDX1/MMADHC/MMAB	0.151491741412447
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1442	38/9376	1.02664428060442	ATP1B1/ATP1B3/NEDD4L/PRKCB/ATP1A1/PIK3CD	0.0701602346120419
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	23/1442	150/9376	0.996985668053629	WNT2/HGF/SHC3/MAP2K2/CCND1/SHC1/RARB/BAX/FGF10/FZD4/FZD2/FZD7/RPS6KB2/TGFB1/FGF7/HRAS/RB1/GRB2/PIK3CD/AKT1/E2F3/DVL3/WNT10A	-0.0158654410963851
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/1442	32/9376	1.01595006934813	TNFRSF1A/BAX/BID/CYCS/PMAIP1	0.0385294953026423
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/1442	39/9376	1.00032006828123	GCSH/TYMS/AHCYL2/MTHFR/DLD/MTHFS	0.000853873296915036
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1442	12/9376	1.08368007397134	NQO1/GGCX	0.123652854458661
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1442	19/9376	1.02664428060442	GCSH/PDHB/DLD	0.0495603831053445
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	22/1442	148/9376	0.96652547137984	WNT2/CDK6/SHC3/MAP2K2/CCND1/SHC1/BAX/FGF10/FZD4/FZD2/FZD7/RPS6KB2/FGF7/HRAS/RB1/CDK4/GRB2/PIK3CD/AKT1/E2F3/DVL3/WNT10A	-0.174990191007929
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	25/1442	168/9376	0.967571494617264	IL33/FTH1/FTL/SLC25A6/PPIA/SQSTM1/CYBB/SLC25A5/PYCARD/IL1A/TNFRSF1A/BAX/VDAC2/BID/CHMP5/VDAC1/CHMP2A/IL1B/CASP1/SMPD1/TNFRSF10B/SLC25A4/JAK3/CHMP1B/CAPN1	-0.180809434772661
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1442	20/9376	0.975312066574202	NPL/UAP1L1/CMAS	-0.0471169098012292
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	24/1442	163/9376	0.957361537741549	IL6/CXCL8/YWHAB/MAP2K2/ATP6AP1/BAX/BID/IKBKE/CYCS/PRKCB/PCNA/TGFB1/IRAK1/HRAS/RB1/GRB2/MAPK13/JAK3/PIK3CD/DDB1/MAP3K1/AKT1/E2F3/ELK1	-0.234108385847889
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	23/1442	157/9376	0.952534077758245	BMP5/WNT2/ID1/YWHAB/AREG/PPP1CA/BMP4/CCND1/ACTG1/ID2/CCND2/FZD4/FZD2/BMP7/FZD7/TGFB1/GLI2/GDF6/SNAI2/PPP2R1A/DLG3/DVL3/WNT10A	-0.255688981065838
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	15/1442	104/9376	0.937800064013656	PLPP4/GPAM/PLD1/DGKI/PLD3/PLPP2/LYPLA1/LPCAT2/AGPAT2/CHKB/PLD4/PCYT2/PLA2G15/MBOAT7/MBOAT2	-0.271920572681469
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	9/1442	63/9376	0.928868634832574	WNT2/BMP4/BAX/FZD4/FZD2/FZD7/GLI2/DVL3/WNT10A	-0.241495358119276
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	14/1442	98/9376	0.928868634832574	PLCB1/CALM2/CALM1/SYNJ2/DGKI/ITPR2/PRKCB/CALM3/CALML4/ITPR3/PIK3CD/ITPR1/PLCB2/PLCD4	-0.301765209077113
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/1442	50/9376	0.910291262135922	IL6/CD86/TNFSF13B/CD28/TGFB1/CD40/CCL28	-0.271140388161429
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/1442	43/9376	0.907267038673677	CD36/ACAT2/PLPP2/AGPAT2/DGAT2/SLC27A4	-0.259824376584207
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	5/1442	36/9376	0.903066728309447	SSBP1/PCNA/POLD4/POLA2/RNASEH2C	-0.248412161570054
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	27/1442	187/9376	0.938803058734527	PLCB1/CYBA/GABARAP/CCL2/TXN/IL6/CXCL8/CYBB/GABARAPL2/CTSB/PYCARD/VDAC2/CXCL1/CARD16/ITPR2/VDAC1/IKBKE/IL1B/NAMPT/CASP1/IFI16/GPSM3/MAPK13/TRPM2/ITPR3/ITPR1/PLCB2	-0.36036164744182
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	19/1442	133/9376	0.928868634832574	GABARAP/IL6/GABARAPL2/MAP2K2/HOMER3/CCND1/CCND2/TGFB1/ATM/PRMT1/HRAS/G6PC3/GRB2/MAPK13/CCNG2/SKP2/CCNB2/PIK3CD/AKT1	-0.352210791344795
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	15/1442	106/9376	0.92010572318321	GSTP1/FOLR2/MAP2K2/CCND1/HSP90B1/PDGFC/ETV5/HRAS/RB1/GRB2/PLAU/PIK3CD/AKT1/E2F3/SPINT1	-0.352655698449136
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1442	22/9376	0.886647333249275	ALDH2/ALDH3A2/ALDH9A1	-0.226916757847596
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/1442	65/9376	0.90028806145311	PLCB1/GNAS/ITPR2/ORAI1/HSD3B2/ADCY8/ITPR3/ITPR1/PLCB2	-0.343896570602255
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/1442	51/9376	0.892442413858747	ENPP2/PLD1/PLD3/PLPP2/PAFAH1B3/LPCAT2/PLD4	-0.328340069023318
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/1442	86/9376	0.907267038673677	SHC3/MAP2K2/AREG/SHC1/EIF4EBP1/PRKCB/RPS6KB2/HRAS/GRB2/PIK3CD/AKT1/ELK1	-0.368296564444193
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	12/1442	86/9376	0.907267038673677	PLCB1/ATP1B1/GNAS/ATP1B3/RYR2/SNAP25/PRKCB/ATP1A1/PCLO/ADCY8/ITPR3/PLCB2	-0.368296564444193
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	6/1442	44/9376	0.886647333249275	GTF2A2/GTF2H5/TAF10/GTF2I/TAF9/TBPL1	-0.321286801730306
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/1442	44/9376	0.886647333249275	MPG/PCNA/POLD4/MBD4/APEX1/NTHL1	-0.321286801730306
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/1442	37/9376	0.878659519436219	MIF/FAH/ADH5/COMT/IL4I1	-0.315267029857043
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1442	15/9376	0.866944059177069	HEXA/GLB1	-0.21985732893741
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	31/1442	217/9376	0.928868634832574	CYP1B1/GSTO1/GNAS/GNAI2/GSTM3/MAP2K2/MGST3/CCND1/HSP90B1/EIF4EBP1/FGF10/IKBKE/MGST1/CYP1A2/PRKCB/GSTT2B/KPNB1/RPS6KB2/MGST2/EPHX1/FGF7/HRAS/RB1/GRB2/ADCY8/PAQR5/KPNA3/PIK3CD/RPS6KA1/AKT1/ARRB2	-0.451948710479608
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	10/1442	73/9376	0.890695951209317	GSTP1/GSTO1/HPGDS/GSTM3/MGST3/MGST1/CYP1A2/GSTT2B/ADH5/MGST2	-0.39967624740987
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9/1442	66/9376	0.886647333249275	CYP1B1/AKR1C1/CYP1A2/COMT/HSD3B2/HSD17B7/SRD5A3/HSD17B1/AKR1C3	-0.393959011851545
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	13/1442	94/9376	0.899223891167704	CCL2/IL6/CXCL8/S100A9/MMP1/HSP90B1/CXCL1/CXCL6/IKBKE/CXCL5/IL1B/MAPK7/MAPK13	-0.4186228214463
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/1442	59/9376	0.881638026281765	MAP2K2/CCND1/BAX/HRAS/GRB2/PIK3CD/AKT1/ELK1	-0.388796482305188
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/1442	52/9376	0.875280059746079	CYP1B1/GNAS/HSD3B2/HSD17B7/ADCY8/HSD17B1/AKR1C3	-0.38446658831699
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	17/1442	122/9376	0.906027602828494	MAP2K2/CDC42/CD28/PTPRC/TEC1/HRAS/VAV1/CD4/CDK4/GRB2/MAPK13/CARD11/PPP3R1/PIK3CD/PPP2R1A/AKT1/PTPN6	-0.445387109709292
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/1442	38/9376	0.855536900503686	ORAI1/PTPRC/CD40/CD4/JAK3	-0.380403025471866
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	25/1442	178/9376	0.913213545481463	PLCB1/BAMBI/WNT2/RAC2/RAC1/RBX1/SKP1/CCND1/CSNK2B/RSPO2/CCND2/FZD4/FZD2/PRKCB/FZD7/APCDD1L/CTBP1/PPP3R1/RAC3/PLCB2/FRZB/CSNK2A1/RSPO3/DVL3/WNT10A	-0.498353388314087
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1442	16/9376	0.812760055478502	MIF/IL4I1	-0.319552883705073
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1442	16/9376	0.812760055478502	HEXA/GLA	-0.319552883705073
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/1442	54/9376	0.842862279755484	HLA-C/HLA-A/HLA-B/CD86/CD28/CD40/HLA-F	-0.493679335729995
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	11/1442	83/9376	0.861721504603713	SKP1/CSNK2B/JARID2/YY1/RBBP7/KDM2B/CBX3/HDAC2/DCAF7/HDAC1/CBX6	-0.539433474781062
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	8/1442	62/9376	0.83897812178426	NUMB/APH1A/HDAC2/CTBP1/NCSTN/HDAC1/DTX4/DVL3	-0.542293983757203
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	16/1442	119/9376	0.874229303371834	CCL2/IL6/MMP14/TNFRSF1A/ICAM1/CXCL1/CXCL6/CXCL5/IL1B/LIF/RHBDF2/MAPK13/PIK3CD/VEGFC/VCAM1/AKT1	-0.588626737748617
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	15/1442	112/9376	0.870814345155538	GNAI2/ITGB1/HSPA8/TNFRSF1A/LY96/CYCS/LAMA5/TGFB1/IRAK1/CD40/MAPK13/LAMC2/PIK3CG/IL10RA/AKT1	-0.586335513351018
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1442	17/9376	0.764950640450355	CA12/CA9	-0.413514725417246
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	18/1442	134/9376	0.873413790961972	PLCB1/CALM2/GNAS/MYL6/MAP2K2/CALM1/PPP1CA/ITPR2/PRKCB/CALM3/GUCY1A1/MYL6B/ADORA2B/ADCY8/CALML4/ITPR3/ITPR1/PLCB2	-0.629184450966536
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	13/1442	99/9376	0.853808543128932	FCGR3A/CFB/C1QA/C1QC/ICAM1/FCGR1A/KRT19/C3AR1/KRT10/FPR1/FCGR2A/ITGAM/PTAFR	-0.623387347468553
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	7/1442	56/9376	0.812760055478502	CCND1/CCND2/DISP1/CDON/GLI2/CSNK1G2/ARRB2	-0.599110224554373
Human Diseases	Substance dependence	hsa05034	Alcoholism	26/1442	191/9376	0.885099955704337	GNG11/GNGT1/CALM2/GNG10/GNG5/GNAS/GNAI2/SHC3/CALM1/PPP1CA/GNG2/SHC1/PKIA/GNB2/BDNF/HDAC8/HDAC9/CALM3/HRAS/HDAC2/GRIN2C/GRB2/ADORA2B/HDAC3/CALML4/HDAC1	-0.683942308230345
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1442	18/9376	0.722453382647557	ACACA/FASN	-0.502461558533733
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	9/1442	73/9376	0.801626356088386	PPIA/RAN/BST2/MAP1A/CD4/SUPT4H1/XPO1/PIN1/SMARCB1	-0.725364105546055
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1442	10/9376	0.650208044382802	SELENBP1	-0.471796713303714
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	15/1442	117/9376	0.833600056901028	CDK2AP1/TFPT/ZNHIT1/ACTG1/MORF4L1/YY1/RBBP7/HDAC2/MRGBP/INO80C/KAT5/HDAC1/MTA1/SMARCB1/MCRS1	-0.772122543408819
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	22/1442	168/9376	0.851462915263193	IL6/IL11/CCND1/IL12RB2/CCND2/PIAS2/IL24/LIF/HRAS/PRL/GRB2/PTPN2/IL13RA1/JAK3/EPOR/CTF1/PIK3CD/CSH1/IL10RA/CNTFR/AKT1/PTPN6	-0.828188225669478
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1442	36/9376	0.722453382647557	AKR1B1/AKR1A1/DCXR/AKR1B10	-0.711272341792793
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1442	36/9376	0.722453382647557	GALNT1/GALNT9/C1GALT1/GALNT12	-0.711272341792793
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/1442	44/9376	0.738872777707729	DYNLL1/GNAS/RAB5C/DCTN4/DCTN6	-0.740139005988281
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/1442	37/9376	0.702927615548975	ASL/IL4I1/GPT2/ASS1	-0.771853942421088
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	20/1442	156/9376	0.833600056901028	CDK6/YWHAB/MAP2K2/CCND1/TNFRSF1A/BAX/BID/EIF3E/IKBKE/CYCS/CLDN11/CLDN23/HRAS/RB1/CDK4/GRB2/PIK3CD/PPP2R1A/AKT1/E2F3	-0.893453968948828
Genetic Information Processing	Transcription	hsa03040	Spliceosome	32/1442	243/9376	0.856241046100809	SRSF9/SF3B6/HSPA8/SNRPD2/SNU13/HNRNPK/LSM7/RBM8A/HNRNPA1/SF3B5/SNRPB/TXNL4A/SNRPG/LSM3/SNRPB2/BUD31/SNRPE/ALYREF/SNRPD3/SNRPC/SRSF2/SNRPF/SNRPD1/LSM4/SF3B2/PRPF40A/PRPF31/THOC3/LSM8/DDX46/CCDC12/MAGOH	-0.967951243633712
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/1442	30/9376	0.650208044382802	GPAA1/PIGZ/MPPE1	-0.818049769967995
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1442	12/9376	0.541840036985668	CD209	-0.677016457284712
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/1442	78/9376	0.750240051210925	ENO1/LSM7/PFKP/LSM3/LSM4/LSM1/LSM8/CNOT7/PABPC4L	-0.944272838056007
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	13/1442	109/9376	0.775477484126277	IL6/CD36/PPP1CA/TNFRSF1A/PRKCB/RPS6KB2/GYS1/G6PC3/SLC27A3/SLC27A4/PIK3CD/RPS6KA1/AKT1	-1.00513810574441
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	30/1442	233/9376	0.837177739548672	COL1A2/COL3A1/COL1A1/ITGA2/ATP1B1/NEBL/COL5A2/ATP1B3/ITGB1/COL6A1/CAPZB/DSG2/ENO1/ITGA11/ITGA3/ACTG1/TPM3/TPM2/TNNT1/DSC2/TLN1/CAPZA2/SNTA1/ATP1A1/MYL5/SGCA/TNNT3/FN1/CSRP2/ANK3	-1.07292545919191
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	29/1442	226/9376	0.834337756066427	ATP1B1/CALM2/GNAS/GNAI2/ATP1B3/RYR2/RAC2/PDE4D/ATP2B1/RAC1/GRIA4/MAP2K2/CALM1/PPP1CA/POPDC3/PLD1/BDNF/ORAI1/GRIA3/CALM3/ATP1A1/VAV1/GRIN2C/ADCY8/CALML4/RAC3/PIK3CD/AKT1/ATP2A2	-1.07470527996356
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	13/1442	110/9376	0.768427688816038	GNAI2/ANAPC11/ANAPC16/MAPK13/ADCY8/CCNB2/PIK3CD/CPEB1/RPS6KA1/AKT1/CDC25B/AURKA/ANAPC10	-1.04149933040918
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	12/1442	103/9376	0.757523935203264	SAP18/PPP1CA/RBM8A/SSU72/ALYREF/RNMT/UPF3A/SRRM1/PELO/PPP2R1A/PABPC4L/MAGOH	-1.05487142469527
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1442	23/9376	0.565398299463306	CTSA/ATP6AP2	-0.889614888246071
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1442	49/9376	0.663477596308981	GNAS/GNAI2/BDNF/GRIN2C/CDK5	-1.0068463598584
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/1442	41/9376	0.634349311592977	SSBP1/SEM1/POLD4/ATM	-1.00028402492325
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	4/1442	41/9376	0.634349311592977	GRIA4/GRIA3/GABRE/GRIN2C	-1.00028402492325
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/1442	33/9376	0.591098222166183	VAMP8/VAMP5/BET1	-1.00312479338549
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	10/1442	90/9376	0.722453382647557	BAX/EIF4EBP1/ADIPOR1/EIF4E2/RPS6KB2/HRAS/AKT1S1/ADCY8/PIK3CD/AKT1	-1.12788552752393
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/1442	59/9376	0.661228519711324	GNAS/GNAI2/PTGS1/ADCY8/PIK3CD/AKT1	-1.11279962393249
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/1442	34/9376	0.573712980337766	RBX1/SKP1/BHLHE41	-1.06155819187044
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1442	26/9376	0.500160034140617	FADS2/ACAA1	-1.08801283104057
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/1442	78/9376	0.666880045520822	PLCB1/TPI1/SYNJ2/PIK3CG/PIK3CD/MINPP1/PLCB2/PLCD4	-1.25943381376486
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1442	28/9376	0.464434317416287	ST3GAL4/B4GALT2	-1.20991420362424
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/1442	90/9376	0.650208044382802	ATP1B1/ABCC3/GNAS/ATP1B3/SLC4A2/ATP1A1/EPHX1/HMGCR/ADCY8	-1.42147394246187
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/1442	68/9376	0.573712980337766	CYP1A2/ADH5/RDH11/LRAT/ALDH1A3/RETSAT	-1.50400939122457
Human Diseases	Immune disease	hsa05310	Asthma	2/1442	32/9376	0.406380027739251	FCER1G/CD40	-1.43396730343747
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/1442	70/9376	0.557321180899544	CD36/TNFRSF1A/ADIPOR1/G6PC3/CPT1C/AKT1	-1.58481440117676
NA	NA	hsa04082	Neuroactive ligand signaling	22/1442	199/9376	0.718822963639278	PLCB1/GNG11/GNGT1/GNG10/GNG5/GNAS/GNAI2/GRIA4/HTR7/GNG2/GNB2/HRH2/GRIA3/PRKCB/GABRE/GRIN2C/ADORA2B/ADCY8/OGFRL1/PLCB2/OGFR/P2RY13	-1.7091421780179
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/1442	45/9376	0.433472029588534	ABCC3/ABCA13/ABCB9	-1.62399874411545
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1442	23/9376	0.282699149731653	B4GALT2	-1.4682904253763
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/1442	66/9376	0.492581851805153	IL6/IL1A/IL12RB2/IL1B/TGFB1	-1.7635399147511
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/1442	47/9376	0.415026411308171	PKM/HK2/PIK3CD	-1.7139170970227
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/1442	26/9376	0.250080017070308	LRAT	-1.63236759645339
NA	NA	hsa04519	Cadherin signaling	47/1442	404/9376	0.756430150643358	CDH2/ARPC1B/ARPC3/BRK1/ARPC2/SCN1B/WNT2/RAC2/YWHAB/DSG2/RAC1/MAP2K2/PPP1CA/PCDH10/ARPC5/MYO1B/PCDH7/ACTG1/ARPC1A/CDC42/PCDH20/ACTR3C/FZD4/KRT19/KRT10/FZD2/ACTR2/DSC2/GABRE/DSC3/FZD7/PCDH12/NCKAP1L/HRAS/VAV1/ADAM10/APH1A/MAPK13/KRT1/RAC3/NCSTN/ARPC5L/CIB2/TMC6/TMC8/DVL3/WNT10A	-2.13349558237649
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	36/1442	323/9376	0.724690080426652	HMGA2/CYP1B1/MARCKS/DDIT4/ZEB2/CDK6/EFNA5/HMOX1/MAP2K2/CDKN2A/CCND1/SHC1/FSCN1/HNRNPK/RDX/CCND2/CCNG1/MMP16/PRKCB/ATM/UBE2I/HRAS/HDAC2/MAPK7/GRB2/SPRY2/DNMT3A/PLAU/STMN1/PIK3CD/HDAC1/EFNA4/CDC25B/E2F3/SOX4/FGFR3	-2.14658964911664
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	13/1442	143/9376	0.591098222166183	FCGR3A/C1QA/C1QC/FCGR1A/CD86/SNRPB/CD28/C6/SNRPD3/SNRPD1/SSB/CD40/FCGR2A	-2.10057295718772
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/1442	72/9376	0.451533364154723	CXCL8/IKBKE/MAPK13/PIN1/MAP3K1	-1.99160763046461
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/1442	109/9376	0.536869027472038	HIF1A/IL6/RUNX1/IL1B/TGFB1/CD4/MAPK13/JAK3/PPP3R1	-2.07333588182371
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1442	30/9376	0.216736014794267	CYP1A2	-1.83180005323788
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/1442	86/9376	0.378027932780699	PLCB1/SCN9A/ADCY8/ITPR3/PLCB2	-2.47021309640952
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/1442	93/9376	0.349574217410108	IL12RB2/CD4/MAPK13/JAK3/PPP3R1	-2.68730659248034
NA	NA	hsa04382	Cornified envelope formation	18/1442	217/9376	0.539343078289882	S100A6/S100A11/S100A10/S100A9/S100A13/DSG2/KRT19/KRT10/S100A16/LAMA5/COL7A1/CLDN11/CLDN23/LAMC2/KRT1/SLC27A4/PPP2R1A/CAPN1	-2.92688466262888
NA	NA	hsa04081	Hormone signaling	18/1442	219/9376	0.53441757072559	PLCB1/GNG11/GNGT1/GNG10/GNG5/GNAS/GNAI2/SLC16A10/GNG2/SLC40A1/GNB2/ADIPOR1/PRL/ADCY8/EPOR/PIK3CD/CSH1/PLCB2	-2.97210537179132
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/1442	54/9376	0.120408897107926	CENPX	-2.76341002474818
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	12/1442	183/9376	0.426365930742821	NOP10/RAN/RPP25/CSNK2B/SNU13/IMP3/EIF6/AK6/XPO1/UTP14A/CSNK2A1/POP5	-3.34082727127527
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	27/1442	370/9376	0.474476140495558	NMB/SPX/BDKRB1/TSPO/NR3C1/GRIA4/HTR7/HRH2/C3AR1/GRIA3/PRSS3/GABRE/PGRMC1/PTGFR/FPR1/GRIN2C/PRL/ADORA2B/CYSLTR1/PTAFR/OGFRL1/CSH1/LPAR6/KISS1/OGFR/P2RY13/APLN	-4.39692947150833
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/1442	449/9376	0.0868874892271004	CALM2/CALM1/CALM3/CALML4/OR3A2/ARRB2	-8.45311673768671