category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	92/550	238/9376	6.58970206264324	F13A1/C1QA/CCL2/RPS23/CYBB/RPS4X/RPLP1/RPS18/C1QC/C1QB/RPS11/RPS12/RPS27A/RPL30/RPL27A/RPL21/RPL26/CFD/RPL39/RPL32/RPL23A/RPL15/RPS14/RPL23/RPS2/RPL13/RPS19/RPL37A/RPL28/FAU/NRP1/RPL11/RPL10/RPL37/RPS24/RPS15/RPL41/RPL24/RPL7A/RPL13A/RPL29/RPL35/RPS15A/UBA52/RPS3A/RPL17/RPL9/RPL35A/RPL18/RPL18A/RPS7/RPLP2/RPL19/RPS9/RPL36/RPL3/RPL34/RPS28/RPL27/RPL38/RPL10A/RPL14/RPS6/RPS16/FCGR2A/RPS20/RPS13/RPL36A/RPS21/RPS5/RPS27/RPS25/RPL8/C1R/RPL12/RPL22/C2/PRKCB/RPS10/JUN/RPS3/AGTR1/RPL5/PRKCA/MMP1/SYK/NLRP3/TLR4/C3AR1/RPL36AL/NFKB1/TNFRSF1A	21.8040205756073
Genetic Information Processing	Translation	hsa03010	Ribosome	72/550	222/9376	5.52884520884521	RPS23/RPS4X/RPLP1/RPS18/RPS11/RPS12/RPS27A/RPL30/RPL27A/RPL21/RPL26/RPL39/RPL32/RPL23A/RPL15/RPS14/RPL23/RPS2/RPL13/RPS19/RPL37A/RPL28/FAU/RPL11/RPL10/RPL37/RPS24/RPS15/RPL41/RPL24/RPL7A/RPL13A/RPL29/RPL35/RPS15A/UBA52/RPS3A/RPL17/RPL9/RPL35A/RPL18/RPL18A/RPS7/RPLP2/RPL19/RPS9/RPL36/RPL3/RPL34/RPS28/RPL27/RPL38/RPL10A/RPL14/RPS6/RPS16/RPS20/RPS13/RPL36A/RPS21/RPS5/RPS27/RPS25/RPL8/RPL12/RPL22/RACK1/RPS10/RPS3/RPL5/RPL36AL/MRPS21	17.0468261383763
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	51/550	205/9376	4.2410288248337	MT-CO2/CD36/MT-ATP6/MT-CYB/COL3A1/COL1A1/CYBA/CYBB/MT-ND1/MT-CO3/MT-CO1/COL1A2/MT-ND2/COX6C/RYR2/ATP5F1E/MT-ND4/UQCRB/MMP2/COX4I2/MT-ND3/NDUFA4L2/COX5B/MT-ND5/COX4I1/UQCR10/NDUFA4/COX6B1/NDUFA13/PRKCB/NCF4/NDUFA1/COX7C/AGTR1/PRKCA/ATP5MC2/COX8A/COX7B/RAC2/TBC1D4/UQCRH/UQCR11/PLCB1/NDUFB2/NFKB1/COX7A2/NDUFS5/SLC25A5/NDUFC2/NDUFB11/NDUFA11	11.7121465721122
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	41/550	138/9376	5.06476943346509	MT-CO2/MT-ATP6/MT-CYB/MT-ND1/MT-CO3/MT-CO1/MT-ND2/COX6C/ATP5F1E/MT-ND4/UQCRB/COX4I2/MT-ND3/NDUFA4L2/COX5B/MT-ND5/COX4I1/UQCR10/NDUFA4/COX6B1/NDUFA13/NDUFA1/COX7C/ATP5MC2/ATP5MG/COX8A/COX7B/ATP6V0B/ATP6V0C/UQCRH/UQCR11/ATP6V1G1/NDUFB2/ATP6V1F/COX7A2/NDUFS5/ATP5ME/NDUFC2/NDUFB11/ATP6V0E1/NDUFA11	12.0080227410881
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	49/550	275/9376	3.03751404958678	MT-CO2/MT-ATP6/C1QA/MT-CYB/CYBA/CYBB/MT-ND1/MT-CO3/C1QC/C1QB/MT-CO1/MT-ND2/COX6C/RYR2/EGR1/ATP5F1E/MT-ND4/UQCRB/HSPA1A/COX4I2/MT-ND3/TUBA1B/NDUFA4L2/COX5B/MT-ND5/COX4I1/UQCR10/NDUFA4/COX6B1/NDUFA13/ITPR2/NCF4/NDUFA1/COX7C/ATP5MC2/COX8A/COX7B/RAC2/UQCRH/UQCR11/NDUFB2/COX7A2/NDUFS5/SLC25A5/NDUFC2/NDUFB11/GRIN2C/NDUFA11/PRNP	8.56066343958078
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	43/550	227/9376	3.22921906287545	MT-CO2/MT-ATP6/MT-CYB/HGF/CYBA/MT-ND1/MT-CO3/MT-CO1/MT-ND2/COX6C/ATP5F1E/MT-ND4/UQCRB/COX4I2/MT-ND3/NDUFA4L2/COX5B/MT-ND5/COX4I1/UQCR10/NDUFA4/COX6B1/NDUFA13/JUN/NDUFA1/COX7C/ATP5MC2/COX8A/COX7B/PTPRJ/GSTA4/MGST2/UQCRH/UQCR11/NDUFB2/PLD1/NFKB1/COX7A2/NDUFS5/SLC25A5/NDUFC2/NDUFB11/NDUFA11	8.48718921256289
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	44/550	268/9376	2.79880597014925	MT-CO2/MT-ATP6/MT-CYB/MT-ND1/MT-CO3/RPS27A/MT-CO1/MT-ND2/COX6C/ATP5F1E/UBB/UBA52/MT-ND4/UQCRB/COX4I2/MT-ND3/TUBA1B/GNAI2/NDUFA4L2/COX5B/MT-ND5/COX4I1/UQCR10/NDUFA4/COX6B1/NDUFA13/ITPR2/NDUFA1/COX7C/ATP5MC2/COX8A/COX7B/UQCRH/UQCR11/NDUFB2/SNCA/COX7A2/NDUFS5/PRKN/SLC25A5/NDUFC2/NDUFB11/CALM2/NDUFA11	7.45804892013534
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	23/550	87/9376	4.50675026123302	MT-CO2/MT-CYB/MT-CO3/MT-CO1/COX6C/RYR2/UQCRB/COX4I2/COX5B/COX4I1/UQCR10/COX6B1/SLC8A1/ATP1B1/COX7C/ATP1B3/COX8A/COX7B/CACNB4/UQCRH/UQCR11/COX7A2/TPM3	8.20285442546203
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	39/550	235/9376	2.82912185686654	MT-CO2/MT-ATP6/MT-CYB/MT-ND1/MT-CO3/PRKG1/MT-CO1/MT-ND2/COX6C/ACTB/ATP5F1E/MT-ND4/UQCRB/COX4I2/RPS6/MT-ND3/NDUFA4L2/COX5B/MT-ND5/COX4I1/UQCR10/NDUFA4/COX6B1/NDUFA13/NDUFA1/COX7C/ATP5MC2/ATP5MG/COX8A/COX7B/UQCRH/UQCR11/NDUFB2/COX7A2/NDUFS5/ATP5ME/NDUFC2/NDUFB11/NDUFA11	7.08866964639032
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	30/550	155/9376	3.29947214076246	CD36/CD14/CYBA/CYBB/FCGR3A/ACTB/HLA-C/MRC1/FCGR1A/FCGR2A/TUBA1B/C1R/HLA-A/ITGB2/NCF4/CLEC7A/CTSS/CORO1A/CD209/TLR4/ATP6V0B/HLA-E/ATP6V0C/MSR1/ATP6V1G1/SEC61G/ATP6V1F/COLEC12/ATP6V0E1/ITGAM	7.20592954771964
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	30/550	157/9376	3.25744064852345	MT-CO2/MT-CYB/MT-CO3/MT-CO1/COX6C/UQCRB/COX4I2/NDUFA4L2/COX5B/COX4I1/UQCR10/NDUFA4/COX6B1/NDUFA13/JUN/NDUFA1/COX7C/COX8A/COX7B/SOCS3/UQCRH/UQCR11/NDUFB2/NFKB1/COX7A2/NDUFS5/NDUFC2/NDUFB11/TNFRSF1A/NDUFA11	7.12048016502537
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	43/550	308/9376	2.37997638724911	MT-CO2/MT-ATP6/MT-CYB/MT-ND1/MT-CO3/MT-CO1/MT-ND2/COX6C/ATP5F1E/MT-ND4/UQCRB/COX4I2/MT-ND3/TUBA1B/NDUFA4L2/COX5B/MT-ND5/COX4I1/UQCR10/NDUFA4/COX6B1/NDUFA13/CLTA/NDUFA1/COX7C/ATP5MC2/COX8A/COX7B/CLTC/UQCRH/UQCR11/PLCB1/NDUFB2/AP2S1/COX7A2/NDUFS5/DCTN4/SLC25A5/NDUFC2/NDUFB11/POLR2L/NDUFA11/SLC1A2	6.14718493957806
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	58/550	480/9376	2.05987878787879	MT-CO2/MT-ATP6/MT-CYB/CYBB/MT-ND1/MT-CO3/WNT2/RPS27A/MT-CO1/MT-ND2/COX6C/RYR2/ATP5F1E/UBB/UBA52/MT-ND4/UQCRB/COX4I2/MT-ND3/TUBA1B/NDUFA4L2/COX5B/MT-ND5/COX4I1/UQCR10/NDUFA4/COX6B1/NDUFA13/ITPR2/PRKCB/TNFRSF1B/NDUFA1/COX7C/PRKCA/ATP5MC2/COX8A/COX7B/CSF1/UQCRH/UQCR11/PLCB1/NDUFB2/SNCA/NFKB1/COX7A2/NDUFS5/LRP6/PRKN/DCTN4/SLC25A5/TANK/NDUFC2/NDUFB11/CALM2/TNFRSF1A/GRIN2C/NDUFA11/PRNP	5.95065063411851
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	15/550	50/9376	5.11418181818182	CD36/CCL2/HBB/HGF/HBA1/HBA2/CR1/VCAM1/GYPC/PECAM1/CD81/ITGB2/ICAM1/TLR4/LRP1	7.28124758353023
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	49/550	388/9376	2.15287722586692	MT-CO2/MT-ATP6/MT-CYB/CYBB/MT-ND1/MT-CO3/WNT2/MT-CO1/MT-ND2/COX6C/ATP5F1E/MT-ND4/UQCRB/COX4I2/MT-ND3/TUBA1B/NDUFA4L2/COX5B/MT-ND5/COX4I1/UQCR10/NDUFA4/COX6B1/NDUFA13/ITPR2/NDUFA1/COX7C/ATP5MC2/COX8A/COX7B/LRP1/CSF1/UQCRH/UQCR11/PLCB1/NDUFB2/SNCA/APOE/NFKB1/COX7A2/NDUFS5/LRP6/SLC25A5/NDUFC2/NDUFB11/CALM2/TNFRSF1A/GRIN2C/NDUFA11	5.78965136259835
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	31/550	193/9376	2.73816297691945	CXCL14/CCL2/CCL3/CCL4L2/GNG2/CCL4/GNG11/LYN/GNAI2/HCK/GNGT1/PRKCB/GNG10/DOCK2/ELMO1/ARRB2/CCL8/CCL3L1/CCR1/RAC2/VAV1/WAS/GRK3/CCL13/PLCB1/PIK3CG/PREX1/GNB4/NFKB1/JAK3/GNG5	6.09062525384176
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	26/550	149/9376	2.97469188529591	MT-ND1/GNG2/GNG11/MT-ND2/MT-ND4/MT-ND3/GNAI2/NDUFA4L2/MT-ND5/NDUFA4/NDUFA13/GNGT1/ITPR2/PRKCB/GNG10/NDUFA1/PRKCA/KCNJ5/PLCB1/NDUFB2/GNB4/NDUFS5/NDUFC2/NDUFB11/GNG5/NDUFA11	6.06522947448219
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	20/550	98/9376	3.47903525046382	FCGR3A/MARCKS/PTPRC/PLPP3/LYN/FCGR1A/FCGR2A/HCK/PRKCB/PRKCA/BIN1/ARPC3/SYK/INPP5D/RAC2/VAV1/WAS/ARPC1B/PLD1/CFL1	6.15819699373644
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	17/550	78/9376	3.71543123543124	CD14/C1QA/C1QC/C1QB/LY96/PYCARD/GNAI2/C1R/C2/ITGB2/JUN/NLRP3/TLR4/NFKB1/CFL1/CALM2/ITGAM	6.01141016235387
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	29/550	196/9376	2.52230055658627	GNG2/RPS27A/GNG11/HLA-C/UBB/UBA52/LYN/CD86/HCK/HLA-A/GNGT1/ITPR2/JUN/RB1/GNG10/CD200R1/SYK/ICAM1/CCR1/HLA-E/NFATC2/PIK3CG/PREX1/GNB4/NFKB1/CALM2/TNFRSF1A/GNG5/CDK6	5.37640681145091
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	11/550	37/9376	5.06810810810811	HBB/HBA1/HBA2/VCAM1/IDO2/LAMA4/PRKCB/PRKCA/ICAM1/PLCB1/IDO1	6.18910971157354
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	18/550	95/9376	3.23000956937799	CCL2/CCL3/CD86/CD28/ITGB2/JUN/MMP1/ICAM1/TLR4/ATP6V0B/CCL3L1/ANGPT1/ATP6V0C/CSF1/ATP6V1G1/ATP6V1F/TNFRSF11A/ATP6V0E1	5.45325949721378
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	43/550	368/9376	1.99193675889328	MT-CO2/MT-ATP6/MT-CYB/MT-ND1/MT-CO3/MT-CO1/MT-ND2/COX6C/ACTB/ATP5F1E/MT-ND4/UQCRB/COX4I2/MT-ND3/TUBA1B/NDUFA4L2/COX5B/MT-ND5/COX4I1/UQCR10/NDUFA4/COX6B1/NDUFA13/TNFRSF1B/NDUFA1/COX7C/ATP5MC2/COX8A/COX7B/UQCRH/UQCR11/NDUFB2/COX7A2/NDUFS5/PRKN/DCTN4/TANK/NDUFC2/NDUFB11/TNFRSF1A/GRIN2C/NDUFA11/SLC1A2	4.84594774234129
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	18/550	97/9376	3.1634114339269	GNG2/PRKG1/GNG11/GUCY1A2/RYR2/GNAI2/GNGT1/PRKCB/GNG10/PRKCA/GUCY1A1/KCNJ5/PLCB1/GNB4/CALM2/GRIN2C/GUCY1B1/GNG5	5.34637505559343
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	20/550	116/9376	2.93918495297806	CYBA/CYBB/ACTB/VCAM1/MMP2/PECAM1/GNAI2/PRKCB/ITGB2/NCF4/THY1/PRKCA/ICAM1/RAC2/VAV1/CDH5/MYL12A/TXK/MSN/ITGAM	5.24599358609917
NA	NA	hsa04517	IgSF CAM signaling	37/550	299/9376	2.10952873213743	MTSS1/NRP1/ACTB/CADM3/SLIT2/MAGI1/PTPRD/PMP22/LYN/TUBA1B/CD86/CD28/ROBO2/UNC5C/ANK2/PRKCB/ITGB2/EPB41L2/SLIT3/MYL6/LCP2/PRKCA/ARPC3/DOK2/ICAM1/CD209/INPP5D/NRP2/ROBO1/IL1RAPL1/VAV1/KDR/ARPC1B/MYL12A/DYNLL1/MSN/ITGAM	4.86729871996463
Organismal Systems	Immune system	hsa04611	Platelet activation	21/550	126/9376	2.84121212121212	COL3A1/COL1A1/FCER1G/PRKG1/COL1A2/GUCY1A2/ACTB/LYN/FCGR2A/GNAI2/TBXAS1/ITPR2/LCP2/SYK/P2RY1/GUCY1A1/FERMT3/MYL12A/PLCB1/PIK3CG/GUCY1B1	5.19401563843483
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	22/550	142/9376	2.64112676056338	CCL2/MEF2C/CYBA/ACTB/VCAM1/KLF2/MMP2/PECAM1/JUN/BMP4/ICAM1/GSTA4/MEF2A/RAC2/CDH5/MGST2/KDR/NFKB1/SUMO2/CALM2/TNFRSF1A/MAP2K5	4.91899505208711
NA	NA	hsa04518	Integrin signaling	23/550	154/9376	2.5460212514758	SPP1/LAMA2/COL1A1/HGF/COL6A1/COL1A2/COL6A2/ACTB/IGF1/VCAM1/CCND2/FREM1/LAMA4/ITGB2/ICAM1/COL6A3/FERMT3/RAC2/KDR/PDGFC/LAMC3/ITGAM/TNXB	4.82890078305255
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	41/550	362/9376	1.93076845806128	SPP1/LAMA2/COL1A1/HGF/GNG2/COL6A1/GNG11/COL1A2/CSH1/COL6A2/AREG/MAGI1/IGF1/CCND2/RPS6/LPAR6/LAMA4/GNGT1/CSF1R/GNG10/FGF7/PRKCA/SYK/KITLG/TLR4/COL6A3/ANGPT1/KDR/CSF1/PDGFC/LAMC3/PIK3CG/CSHL1/GNB4/NFKB1/PIK3AP1/IL2RA/JAK3/GNG5/CDK6/TNXB	4.50839736474329
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	28/550	214/9376	2.23048428207307	B2M/GNG2/GNG11/HLA-C/BST2/GNAI2/CD4/HLA-A/GNGT1/ITPR2/PRKCB/JUN/AP1S2/TNFRSF1B/GNG10/ELOB/PRKCA/TLR4/HLA-E/RAC2/NFATC2/GNB4/NFKB1/CFL1/CALM2/TNFRSF1A/GNG5/AP1B1	4.5454076113021
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	31/550	250/9376	2.11386181818182	LGMN/CTSC/CD68/NPC2/CD63/LAPTM5/AP1S2/CLTA/CTSZ/CTSS/CLTC/ATP6V0B/LAMTOR4/BLOC1S1/ATP6V0C/ATP6V1G1/ATP6V1F/CTSB/AP2S1/LAMTOR2/DMXL2/ASAH1/MAN2B1/ATP6V0E1/CTBS/ARSB/MANBA/FUCA1/MCOLN1/HYAL2/AP1B1	4.4560095263242
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	29/550	227/9376	2.1778454144974	CCL2/B2M/CCL3/CCL4L2/GNG2/CCL4/GNG11/HLA-C/GNAI2/HLA-A/GNGT1/ITPR2/PRKCB/RB1/GNG10/PRKCA/CCL3L1/CCR1/HLA-E/RAC2/NFATC2/PLCB1/GNB4/NFKB1/IL10RA/CALM2/TNFRSF1A/GNG5/CDK6	4.48434927839458
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	21/550	140/9376	2.55709090909091	SPP1/MEF2C/GNG2/GNG11/RYR2/EGR1/KLF2/RPS6/GNAI2/SLC8A1/GNGT1/ITPR2/GNG10/AGTR1/PDE3B/MEF2A/PLCB1/PIK3CG/GNB4/CALM2/GNG5	4.63362673782613
Human Diseases	Substance dependence	hsa05032	Morphine addiction	16/550	91/9376	2.99732267732268	GNG2/GNG11/PDE3A/GNAI2/PDE4B/GNGT1/PDE4D/PRKCB/GNG10/PRKCA/PDE3B/ARRB2/GRK3/KCNJ5/GNB4/GNG5	4.77928573921987
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	21/550	142/9376	2.52107554417414	TYROBP/CYBA/FCGR3A/FCGR1A/FCGR2A/ITPR2/JUN/NCF4/CSF1R/LCP2/LILRB5/JUNB/SYK/SPI1/SOCS3/CSF1/NFATC2/NFKB1/TNFRSF11A/TNFRSF1A/SIRPA	4.55916218993026
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	17/550	103/9376	2.81362753751103	COL3A1/COL1A1/COL14A1/COL15A1/COL6A1/COL1A2/COL6A2/SLC16A10/SLC8A1/ATP1B1/ATP1B3/COL5A2/KCNQ1/COL6A3/ELN/COL21A1/PRCP	4.61999606020089
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	20/550	138/9376	2.47061923583663	CCL2/ACTB/FCGR2A/PYCARD/FYB1/CD4/JUN/LCP2/ELMO1/ARPC3/SKAP2/NLRP3/TLR4/RAC2/VAV1/WAS/ARPC1B/NFATC2/WIPF1/NFKB1	4.34446024958271
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	27/550	216/9376	2.13090909090909	CD36/CD14/CCL2/CYBA/CYBB/CCL3/LY96/HSPA1A/VCAM1/LYN/PYCARD/JUN/NCF4/PRKCA/MMP1/NLRP3/ICAM1/TLR4/CCL3L1/VAV1/POU2F2/NFATC2/PLCB1/NFKB1/TANK/CALM2/TNFRSF1A	4.19751111990126
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	11/550	53/9376	3.53811320754717	SLC8A1/ATP1B1/PRKCB/CLTA/PRKCA/ATP2B1/ATP1B3/CLTC/PLCB1/AP2S1/KL	4.62547249841405
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	13/550	78/9376	2.84121212121212	CYBA/CYBB/FCGR3A/CR1/FCGR1A/FCGR2A/PRKCB/ITGB2/JUN/NCF4/TLR4/NFKB1/ITGAM	4.07606759180036
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	14/550	88/9376	2.71206611570248	F13A1/C1QA/C1QC/C1QB/CR1/CFD/A2M/C1R/C2/ITGB2/VSIG4/PROS1/C3AR1/ITGAM	4.02796590824262
Organismal Systems	Nervous system	hsa04730	Long-term depression	11/550	60/9376	3.12533333333333	PRKG1/GUCY1A2/IGF1/LYN/GNAI2/ITPR2/PRKCB/PRKCA/GUCY1A1/PLCB1/GUCY1B1	4.12261672032496
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	25/550	212/9376	2.01029159519726	HGF/ACTB/MAGI1/IGF1/GNAI2/FYB1/DOCK4/PRKCB/ITGB2/CSF1R/FGF7/LCP2/PRKCA/KITLG/P2RY1/ANGPT1/RAC2/VAV1/KDR/CSF1/PDGFC/PLCB1/CALM2/ITGAM/EVL	3.71413043625348
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	20/550	154/9376	2.21393152302243	MEF2C/GUCY1A2/RYR2/ACTB/GNAI2/ITPR2/PRKCB/JUN/MYL6/PRKCA/CACNB4/TRPM2/GUCY1A1/KCNJ5/NFATC2/PLCB1/PIK3CG/CALM2/GUCY1B1/MAP2K5	3.79163926530732
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/550	100/9376	2.55709090909091	CXCL14/CCL2/CCL3/CCL4L2/CCL4/TNFRSF1B/CSF1R/CCL8/CCL3L1/CCR1/CCL13/CSF1/IL10RA/IL2RA/TNFRSF1A	3.90767665659637
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	21/550	166/9376	2.15658269441402	MEF2C/PRKG1/GUCY1A2/PDE3A/GNAI2/SLC8A1/ATP1B1/ITPR2/AGTR1/ATP2B1/ATP1B3/PDE3B/GUCY1A1/MEF2A/NFATC2/PLCB1/PIK3CG/GATA4/SLC25A5/CALM2/GUCY1B1	3.75306373843255
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	15/550	101/9376	2.53177317731773	CCL2/COL3A1/COL1A1/CYBB/COL1A2/EGR1/VCAM1/MMP2/PRKCB/JUN/AGTR1/PRKCA/ICAM1/PLCB1/NFKB1	3.86352039811667
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	22/550	181/9376	2.07204419889503	CD14/FCER1G/FCGR3A/CR1/MRC1/FCGR1A/FCGR2A/ITGB2/CLEC7A/CTSS/CORO1A/SYK/CD209/TLR4/ATP6V0B/ATP6V0C/NFKB1/TLR1/IL10RA/CALM2/TNFRSF1A/ITGAM	3.63547475421129
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/550	103/9376	2.48261253309797	CD14/LAMA2/COL3A1/COL1A1/COL1A2/LAMA4/PRKCB/ITGB2/PRKCA/TLR4/PLCB1/LAMC3/NFKB1/GNA14/ITGAM	3.77677550657251
Organismal Systems	Digestive system	hsa04970	Salivary secretion	14/550	93/9376	2.56625610948192	PRKG1/CST3/GUCY1A2/LYZ/ATP1B1/ITPR2/PRKCB/PRKCA/ATP2B1/ATP1B3/GUCY1A1/PLCB1/CALM2/GUCY1B1	3.78917879722128
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	23/550	195/9376	2.01070396270396	CYBA/CYBB/FCGR3A/CR1/ACTB/HDAC9/FCGR1A/FCGR2A/PRKCB/ITGB2/NCF4/CLEC7A/CLCN5/PRKCA/SYK/TLR4/ATG7/RAC2/PLCB1/NFKB1/SLC25A5/HDAC8/ITGAM	3.56025661335975
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	16/550	115/9376	2.37179446640316	MEF2C/EGR1/GNAI2/NACA/PDE4B/PDE4D/ITPR2/PRKCB/PRKCA/NR4A2/ARRB2/MEF2A/PLCB1/PLD1/LRP6/KL	3.69482646864837
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	15/550	105/9376	2.43532467532468	CD14/CCL4L2/CCL4/LY96/EDA/VCAM1/LYN/PRKCB/SYK/ICAM1/TLR4/CCL13/NFKB1/TNFRSF11A/TNFRSF1A	3.69204113816941
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	16/550	116/9376	2.35134796238245	GNG2/GNG11/GNAI2/GNGT1/ITPR2/PRKCB/GNG10/PRKCA/GRK3/PLCB1/PLD1/GNB4/TRPC1/GRIN2C/GNG5/SLC1A2	3.65574347736118
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	17/550	130/9376	2.22925874125874	COL3A1/COL1A1/GNG2/GNG11/COL1A2/MMP2/GNAI2/GNGT1/JUN/GNG10/PRKCA/MMP1/ARRB2/PLCB1/GNB4/NFKB1/GNG5	3.52308448800485
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	14/550	99/9376	2.41072543617998	C1QA/FCGR3A/C1QC/C1QB/CFD/FCGR1A/FCGR2A/C1R/C2/ITGB2/ICAM1/C3AR1/PTAFR/ITGAM	3.52242161431331
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/550	89/9376	2.49005107252298	PRKG1/GUCY1A2/TUBA1B/GNAI2/GJA1/ITPR2/PRKCB/PRKCA/GUCY1A1/PDGFC/PLCB1/GUCY1B1/MAP2K5	3.52568458115008
Organismal Systems	Endocrine system	hsa04924	Renin secretion	11/550	69/9376	2.71768115942029	GUCY1A2/PDE3A/GNAI2/ITPR2/AGTR1/PDE3B/GUCY1A1/PLCB1/CTSB/CALM2/GUCY1B1	3.57476306323593
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/550	70/9376	2.67885714285714	LAMA2/ACTB/HLA-C/CD86/CD28/HLA-A/ITGB2/DTNA/ICAM1/HLA-E/RAC2	3.51938079722386
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/550	51/9376	3.00834224598931	ACTB/PRKCA/KCNQ1/ATP6V0B/ATP6V0C/ATP6V1G1/SEC61G/ATP6V1F/ATP6V0E1	3.58990877839575
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	22/550	201/9376	1.86587064676617	CD14/MEF2C/MAF/RUNX1T1/IGF1/CCND2/NR4A3/FLI1/BMP2K/FCGR1A/CD86/CSF1R/RUNX1/SPI1/DUSP6/NUPR1/PROM1/LMO2/ETV5/NFKB1/TSPAN7/ITGAM	3.09765488648664
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	22/550	203/9376	1.84748768472906	SPP1/LAMA2/COL1A1/HGF/COL6A1/COL1A2/COL6A2/ACTB/IGF1/CCND2/LAMA4/PRKCB/JUN/PRKCA/COL6A3/RAC2/VAV1/KDR/PDGFC/MYL12A/LAMC3/TNXB	3.04726862089912
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	10/550	65/9376	2.62265734265734	SPP1/KISS1/CGA/ITPR2/PRKCB/PRKCA/ARRB2/KCNJ5/PLCB1/TRPC1	3.2769540805159
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	11/550	76/9376	2.46736842105263	ACTB/GNAI2/ATP1B1/ITPR2/PRKCB/PRKCA/ATP1B3/KCNQ1/PLCB1/HRH2/CALM2	3.20619189359125
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	16/550	133/9376	2.0507997265892	TYROBP/FCER1G/HCST/FCGR3A/HLA-C/HLA-A/PRKCB/ITGB2/LCP2/PRKCA/SYK/ICAM1/HLA-E/RAC2/VAV1/NFATC2	3.04666228536382
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	13/550	100/9376	2.21614545454545	CD36/CD14/CR1/FCGR1A/CD4/CSF1R/KITLG/CD34/CSF1/CD37/CD33/IL2RA/ITGAM	3.05203965677742
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	12/550	89/9376	2.29850868232891	SPP1/CD36/LAMA2/COL1A1/COL6A1/COL1A2/COL6A2/FREM1/LAMA4/COL6A3/LAMC3/TNXB	3.07246652426803
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	18/550	160/9376	1.91781818181818	VCAN/HLA-C/CADM3/PTPRC/PTPRD/VCAM1/PECAM1/CD86/CD28/CD4/HLA-A/ITGB2/SIGLEC1/ICAM1/HLA-E/CD34/CDH5/ITGAM	2.92301091052203
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	20/550	187/9376	1.823237724842	CCL2/CYBA/CYBB/IFI16/PYCARD/ITPR2/JUN/GABARAP/ANTXR2/GPSM3/NLRP3/NAMPT/ANTXR1/TLR4/TRPM2/PLCB1/CTSB/NFKB1/CARD8/TANK	2.83855270638533
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/550	91/9376	2.24799200799201	LYN/CD81/PRKCB/JUN/LILRB5/SYK/INPP5D/RAC2/VAV1/NFATC2/NFKB1/PIK3AP1	2.9862527843782
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	13/550	103/9376	2.15159752868491	C1QA/CCL2/CCL3/C1QC/C1QB/GNAI2/JUN/TLR4/CCL3L1/PLCB1/NFKB1/GNA14/TNFRSF1A	2.93355495294413
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	21/550	204/9376	1.75486631016043	LUM/DCN/COL1A1/HGF/WNT2/COL1A2/ACTB/IGF1/CD63/MMP2/GPC3/RPS6/ANK2/ITPR2/PRKCB/PRKCA/TLR4/VAV1/KDR/TWIST1/MSN	2.72106004415972
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/550	42/9376	2.84121212121212	FTL/CYBB/SLC40A1/ATG7/NCOA4/GPX4/PRNP	2.98524234682695
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	13/550	109/9376	2.03316096747289	SPP1/CD14/CCL3/CCL4L2/CCL4/LY96/CD86/JUN/TLR4/CCL3L1/MAP3K8/NFKB1/TLR1	2.7082994350416
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	24/550	250/9376	1.63653818181818	DAB2/FOLR2/HLA-C/WWP1/HSPA1A/PSD3/HLA-A/CYTH4/CLTA/BIN1/ARPC3/CLTC/ARRB2/HLA-E/EPS15/SNX6/GRK3/ARPC1B/SNX3/PLD1/AP2S1/WIPF1/CAPZA2/IL2RA	2.54647403811799
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	23/550	238/9376	1.64742551566081	HGF/GNG2/GNG11/IGF1/RGL1/GNGT1/PRKCB/CSF1R/GNG10/FGF7/PRKCA/KITLG/ANGPT1/RAC2/KDR/CSF1/PDGFC/PLD1/GNB4/NFKB1/CALM2/GNG5/RALGAPA2	2.52544395147353
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	11/550	89/9376	2.10696629213483	GNG2/GNG11/GNAI2/GNGT1/PRKCB/GNG10/GABARAP/PRKCA/GNB4/SLC12A5/GNG5	2.61924846738598
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/550	56/9376	2.43532467532468	CD14/CR1/HSPA1A/PYCARD/ITGB2/TLR4/NFKB1/ITGAM	2.68918840348025
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	10/550	79/9376	2.15788262370541	SYT1/CLTA/CLTC/ATP6V0B/ATP6V0C/ATP6V1G1/ATP6V1F/AP2S1/ATP6V0E1/SLC1A2	2.57983356049164
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	13/550	115/9376	1.92708300395257	GNG2/GNG11/GNAI2/GNGT1/ITPR2/PRKCB/GNG10/PRKCA/KCNQ1/PLCB1/PIK3CG/GNB4/GNG5	2.49702918733839
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	13/550	115/9376	1.92708300395257	GNG2/GNG11/GNAI2/GNGT1/ITPR2/PRKCB/GNG10/PRKCA/KCNJ5/PLCB1/GNB4/TRPC1/GNG5	2.49702918733839
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/550	68/9376	2.25625668449198	CD14/RUNX1T1/FCGR1A/CSF1R/RUNX1/SPI1/DUSP6/NFKB1/ITGAM	2.59531260520082
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	16/550	154/9376	1.77114521841795	RYR2/GNAI2/SLC8A1/ATP1B1/CREM/AGTR1/PRKCA/ATP2B1/ATP1B3/KCNQ1/CACNB4/SCN1B/PLCB1/PIK3CG/CALM2/TPM3	2.40862390831369
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/550	69/9376	2.22355731225296	FCER1G/LYN/LCP2/PRKCA/SYK/INPP5D/RAC2/VAV1/ALOX5AP	2.54641407784336
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/550	38/9376	2.69167464114833	IGF1/ATP1B1/PRKCB/PRKCA/ATP1B3/HSD11B2	2.60835515000815
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	14/550	133/9376	1.79444976076555	GNG2/GNG11/GNAI2/GNGT1/ITPR2/PRKCB/GNG10/PRKCA/ARRB2/KCNJ5/PLCB1/GNB4/CALM2/GNG5	2.30340764514393
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	26/550	298/9376	1.48734594264796	CXCL14/CCL2/BMP5/CCL3/CCL4L2/CCL4/CSH1/IL12RB2/EDA/GDF15/CD4/BMP4/TNFRSF1B/CSF1R/CCL8/CCL3L1/CCR1/CCL13/CSF1/CSHL1/IL10RA/TNFRSF11A/TNFSF12/IL2RA/TNFRSF1A/TNFRSF25	2.13420149093845
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	11/550	98/9376	1.9134693877551	ATP1B1/ITPR2/PRKCB/AGTR1/PRKCA/NR4A2/ATP2B1/ATP1B3/KCNJ5/PLCB1/CALM2	2.26915871264487
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	26/550	300/9376	1.4774303030303	CD14/MEF2C/HGF/AREG/IGF1/HSPA1A/MKNK1/PRKCB/JUN/CSF1R/FGF7/PRKCA/KITLG/DUSP6/ARRB2/CACNB4/ANGPT1/RAC2/KDR/CSF1/PDGFC/DUSP9/MAP3K8/NFKB1/TNFRSF1A/MAP2K5	2.09801401902313
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	21/550	233/9376	1.53644947327351	DCN/LAMA2/COL3A1/COL1A1/COL6A1/COL1A2/COL6A2/VCAN/ACTB/ATP1B1/ANK2/VIM/DTNA/ATP1B3/COL5A2/COL6A3/ELN/FBLN2/FBLN1/CAPZA2/TPM3	2.06989085233031
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	11/550	102/9376	1.83843137254902	RYR2/ATP1B1/ITPR2/PRKCB/PRKCA/ATP2B1/ATP1B3/KCNQ1/PLCB1/TRPC1/CCK	2.12529432191639
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	20/550	224/9376	1.52207792207792	B2M/NRP1/EGR1/HLA-C/CCND2/CD4/HLA-A/ITGB2/JUN/RB1/SPI1/ICAM1/TSPO/HLA-E/NFATC2/NFKB1/SLC25A5/IL2RA/JAK3/TNFRSF1A	1.97417820397546
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/550	44/9376	2.32462809917355	HLA-C/CD86/CD28/HLA-A/HLA-E/ICA1	2.19845691100673
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/550	105/9376	1.78590476190476	FCER1G/PYCARD/ITPR2/JUN/CLEC7A/SYK/NLRP3/CD209/NFATC2/NFKB1/CALM2	2.02155844006463
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/550	93/9376	1.83304007820137	CGA/EGR1/MMP2/ITPR2/PRKCB/JUN/PRKCA/PLCB1/PLD1/CALM2	2.01533949808521
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/550	82/9376	1.8710421286031	LGMN/B2M/HLA-C/HSPA1A/CD4/HLA-A/CTSS/HLA-E/CTSB	1.97756047792671
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	13/550	134/9376	1.65383989145183	PRKG1/GUCY1A2/ITPR2/PRKCB/MYL6/AGTR1/PRKCA/RAMP2/GUCY1A1/PPP1R14A/PLCB1/CALM2/GUCY1B1	1.9029433176551
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/550	71/9376	1.92081946222791	LYN/JUN/ATP6V0B/ATP6V0C/ATP6V1G1/ATP6V1F/NFKB1/ATP6V0E1	1.94415325541065
NA	NA	hsa04081	Hormone signaling	19/550	219/9376	1.47898713158987	GNG2/PRKG1/CGA/GNG11/CSH1/SLC40A1/SLC16A10/IGF1/GNAI2/GNGT1/GNG10/AGTR1/RAMP2/PLCB1/CSHL1/GNB4/GNA14/GNG5/CCK	1.79041751432944
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	21/550	248/9376	1.44351906158358	CD14/LY96/ACTB/PTPRC/PYCARD/TUBA1B/CYTH4/JUN/RPS3/NCKAP1L/ELMO1/ARPC3/NLRP3/TLR4/ARPC1B/MYL12A/PIK3CG/DYNLL1/NFKB1/DCTN4/TNFRSF1A	1.76699506182679
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	11/550	110/9376	1.70472727272727	CYBB/IGF1/RPS6/MKNK1/PRKCB/ELOB/PRKCA/LDHB/TLR4/ANGPT1/NFKB1	1.85590736369447
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/550	112/9376	1.67428571428571	LAMA2/LY96/HSPA1A/GNAI2/LAMA4/TLR4/LAMC3/PIK3CG/NFKB1/IL10RA/TNFRSF1A	1.79200294129873
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/550	61/9376	1.95624441132638	FTL/SLC40A1/SLC8A1/ATP1B1/ATP2B1/ATP1B3/ATOX1	1.87036953185846
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	21/550	254/9376	1.4094201861131	HGF/RYR2/SLC8A1/ITPR2/PRKCB/HRH1/FGF7/AGTR1/PRKCA/ATP2B1/PTAFR/KDR/NFATC2/PDGFC/PLCB1/HRH2/GNA14/SLC25A5/CALM2/GRIN2C/MCOLN1	1.65130044190799
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/550	17/9376	3.00834224598931	CD209/NRP2/PCDH11X	2.06886657105731
Human Diseases	Immune disease	hsa05330	Allograft rejection	5/550	39/9376	2.18554778554779	HLA-C/CD86/CD28/HLA-A/HLA-E	1.85196472024847
NA	NA	hsa04082	Neuroactive ligand signaling	17/550	199/9376	1.45629968021928	GNG2/GNG11/TAC3/GNAI2/GNGT1/PRKCB/HRH1/GNG10/PRKCA/P2RY1/PLCB1/OGFRL1/GNB4/HRH2/GRIN2C/GNG5/SLC1A2	1.6240947338816
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	8/550	76/9376	1.79444976076555	CD36/PLTP/MMP1/SLC27A4/FABP5/GK/FABP4/DBI	1.73586833837189
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	14/550	157/9376	1.52013896931094	CD36/C1QA/C1QC/C1QB/GAS6/PECAM1/STAB1/PROS1/ELMO1/ATP8A1/LRP1/NFATC2/HAVCR2/SIRPA	1.6406363624478
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/550	28/9376	2.43532467532468	ATP6V0C/ATP6V1G1/ATP6V1F/ATP6V0E1	1.8986933804035
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	17/550	200/9376	1.44901818181818	ACTB/FCGR2A/PYCARD/TUBA1B/CYTH4/JUN/RPS3/NCKAP1L/ARPC3/NLRP3/TLR4/ARPC1B/MYO5A/WIPF1/NFKB1/MYO1F/TNFRSF1A	1.60227569076645
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	26/550	333/9376	1.33101829101829	SPP1/LAMA2/COL1A1/WNT2/COL6A1/COL1A2/COL6A2/HLA-C/RBPJ/MAGI1/CCND2/LAMA4/HLA-A/RB1/ATP6V0B/COL6A3/HLA-E/ATP6V0C/ATP6V1G1/ATP6V1F/LAMC3/NFKB1/TNFRSF1A/ATP6V0E1/CDK6/TNXB	1.5353339908393
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/550	52/9376	1.96699300699301	CD36/PLTP/NPC2/TSPO/LRP1/APOE	1.74545595471567
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/550	18/9376	2.84121212121212	MAN2B1/MANBA/FUCA1	1.95179220333321
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/550	119/9376	1.57579831932773	CCL2/VCAM1/JUN/TNFRSF1B/JUNB/ICAM1/SOCS3/CSF1/MAP3K8/NFKB1/TNFRSF1A	1.57795190891159
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	9/550	93/9376	1.64973607038123	MAF/RBPJ/IL12RB2/CD4/JUN/NFATC2/NFKB1/IL2RA/JAK3	1.57187967330119
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/550	54/9376	1.89414141414141	CGA/HLA-C/CD86/CD28/HLA-A/HLA-E	1.64487751007081
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/550	80/9376	1.70472727272727	HGF/IGF1/GAS6/RPS6/PRKCB/PRKCA/KDR/PDGFC	1.58016717625666
Human Diseases	Infectious disease: viral	hsa05162	Measles	12/550	136/9376	1.50417112299465	HSPA1A/CCND2/CD28/RACK1/JUN/CD209/TLR4/NFKB1/MSN/IL2RA/JAK3/CDK6	1.47841533031286
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/550	45/9376	1.89414141414141	HLA-C/CD86/CD28/HLA-A/HLA-E	1.50083653841791
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	15/550	184/9376	1.3897233201581	EPHA3/NRP1/SLIT2/GNAI2/ROBO2/UNC5C/SLIT3/PRKCA/ROBO1/RAC2/NFATC2/MYL12A/EPHA7/CFL1/TRPC1	1.33273965099434
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/550	73/9376	1.6346699875467	HGF/RARB/PRKCB/RB1/PRKCA/JAK3/CDK6	1.35888561955739
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/550	23/9376	2.22355731225296	AGTR1/ATP6AP2/PRCP	1.4665530891474
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/550	75/9376	1.59107878787879	CGA/ATP1B1/ITPR2/PRKCB/PRKCA/ATP1B3/PLCB1	1.28291004303446
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	14/550	178/9376	1.34079673135853	WNT2/SERPINF1/PRICKLE1/RSPO2/CCND2/RSPO3/PRKCB/JUN/PRKCA/RAC2/NFATC2/FRZB/PLCB1/LRP6	1.14589214042096
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/550	149/9376	1.37293471629042	FCER1G/PLPP3/LPAR6/CYTH4/AGTR1/PRKCA/SYK/KITLG/PDGFC/PLCB1/PIK3CG/PLD1	1.14546205924341
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	17/550	226/9376	1.28231697506034	CGA/RYR2/PDE3A/GNAI2/PDE4B/PDE4D/ATP1B1/JUN/ATP2B1/ATP1B3/PDE3B/RAC2/VAV1/PLD1/NFKB1/CALM2/GRIN2C	1.07242192918379
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	10/550	122/9376	1.3973174366617	SLC16A10/ACTB/ATP1B1/PRKCB/BMP4/PRKCA/ATP1B3/TBC1D4/PLCB1/GATA4	1.10265033577664
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	10/550	122/9376	1.3973174366617	CSH1/IGF1/GNAI2/ITPR2/PRKCB/JUNB/PRKCA/SOCS3/PLCB1/CSHL1	1.10265033577664
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/550	125/9376	1.36378181818182	FCER1G/GNAI2/PRKCB/PRKCA/RAC2/PLCB1/PLD1/NFKB1/TNFRSF1A/ASAH1	1.02208420445912
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/550	67/9376	1.52662143826323	ITPR2/PRKCB/PRKCA/PLCB1/CALM2/GRIN2C	1.07986494319893
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	12/550	157/9376	1.30297625940938	HLA-C/CCND2/HLA-A/ITPR2/RB1/HLA-E/NFATC2/NFKB1/GATA4/SLC25A5/CALM2/CDK6	0.955655887125602
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/550	83/9376	1.43772179627601	CCL4L2/CCL4/IFI16/PYCARD/NLRP3/NFKB1/POLR2L	0.999871689239826
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	13/550	173/9376	1.28100893326327	CCL2/ACTB/PYCARD/PRKCB/PRKCA/NLRP3/ICAM1/TLR4/SOCS3/NFKB1/SLC25A5/TNFRSF1A/CDK6	0.931244001423123
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	10/550	128/9376	1.33181818181818	GUCY1A2/PDE3A/ENPP1/PDE4B/PDE4D/PDE3B/GUCY1A1/NME2/GUCY1B1/APRT	0.943552946073984
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	15/550	205/9376	1.24736141906874	B2M/HLA-C/RBPJ/CCND2/LYN/HLA-A/JUN/RB1/VIM/SYK/ICAM1/HLA-E/NFKB1/JAK3/CDK6	0.893893066985407
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/550	99/9376	1.37755739210285	PLPP3/PRKCB/JUN/PRKCA/RAC2/WAS/PDGFC/PLD1	0.942718040292825
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/550	99/9376	1.37755739210285	LAMA2/RYR2/ACTB/IGF1/SLC8A1/DTNA/CACNB4/TPM3	0.942718040292825
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	18/550	253/9376	1.21284944304707	CD14/RPS27A/ACTB/UBB/UBA52/PYCARD/CYTH4/ITPR2/JUN/ELMO1/ARPC3/NLRP3/TLR4/ARPC1B/MYL12A/PLCB1/NFKB1/TNFRSF1A	0.856739839587556
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/550	56/9376	1.52207792207792	DISP1/CCND2/ARRB2/GRK3/GAS1	0.978152133730601
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/550	86/9376	1.38756871035941	RYR2/ATP1B1/PRKCB/PRKCA/ATP1B3/PLCB1/CCK	0.901311884989146
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/550	86/9376	1.38756871035941	LAMA2/RYR2/ACTB/SLC8A1/GJA1/DTNA/CACNB4	0.901311884989146
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/550	73/9376	1.40114570361146	HGF/IGF1/RB1/FGF7/PDGFC/CDK6	0.858889089890561
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/550	59/9376	1.44468412942989	HPGDS/LAP3/GSTA4/MGST2/GPX4	0.855312087079417
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/550	59/9376	1.44468412942989	PRKG1/CGA/GNAI2/PDE3B/FABP4	0.855312087079417
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/550	105/9376	1.29883982683983	LAMA2/RYR2/ACTB/IGF1/SLC8A1/DTNA/CACNB4/TPM3	0.768696416486038
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/550	60/9376	1.42060606060606	PRKCB/PRKCA/RAC2/KDR/NFATC2	0.815870880547942
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	10/550	137/9376	1.24432647644326	CTSC/ACTB/TUBA1B/ITPR2/JUN/CTSZ/CTSS/CTSB/NFKB1/TNFRSF1A	0.71912328824555
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/550	76/9376	1.34583732057416	IGF1/PRKCB/RB1/PRKCA/CALM2/CDK6	0.755652634892317
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	9/550	122/9376	1.25758569299553	PTPRC/CD28/CD4/JUN/LCP2/VAV1/NFATC2/MAP3K8/NFKB1	0.714861530516256
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	12/550	170/9376	1.20333689839572	ACTB/MAGI1/TUBA1B/JUN/MYL6/ARPC3/RUNX1/WAS/ARPC1B/MYL12A/GATA4/MSN	0.667867317555319
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	7/550	93/9376	1.28312805474096	ACTB/PTPRJ/RAC2/CDH5/WAS/MYL12A/PTPRB	0.684960023733162
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	7/550	93/9376	1.28312805474096	LAMA2/RARB/LAMA4/RB1/LAMC3/NFKB1/CDK6	0.684960023733162
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/550	78/9376	1.31132867132867	ACTB/CLTA/ELMO1/ARPC3/CLTC/ARPC1B	0.689218093331717
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/550	19/9376	1.79444976076555	ARSB/HYAL2	0.865286535303465
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/550	63/9376	1.35295815295815	PTGDS/HPGDS/TBXAS1/LTC4S/GPX4	0.701671299190324
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/550	48/9376	1.42060606060606	ATP1B1/PRKCB/ATP1B3/PLCB1	0.729267563922913
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	14/550	205/9376	1.16420399113082	HLA-C/RBPJ/CCND2/HDAC9/LYN/HLA-A/JUN/RB1/SYK/HLA-E/NFKB1/HDAC8/JAK3/CDK6	0.593386025176329
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	11/550	158/9376	1.18683544303797	WNT2/IGF1/RPS6/PRKCB/PRKCA/LAMTOR4/ATP6V1G1/ATP6V1F/LAMTOR2/LRP6/TNFRSF1A	0.591227299612205
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/550	49/9376	1.39161410018553	GNAI2/JUN/NFKB1/GRIN2C	0.686073102816156
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	10/550	143/9376	1.19211697393516	C1QA/FCGR3A/C1QC/C1QB/FCGR1A/FCGR2A/CD86/C1R/CD28/C2	0.577892901293498
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	10/550	144/9376	1.18383838383838	CD14/C1QA/C1QC/C1QB/LY96/C2/TLR4/C3AR1/NFKB1/TNFRSF1A	0.554950903661441
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/550	66/9376	1.29146005509642	MAF/IL12RB2/JUN/TLR4/NFKB1	0.593145433670006
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/550	99/9376	1.20536271808999	IGF1/ITPR2/PRKCB/HRH1/PRKCA/PLCB1/CALM2	0.512767444622744
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/550	52/9376	1.31132867132867	CGA/HSD17B2/IGF1/HSD17B1	0.561959062076522
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/550	69/9376	1.23530961791831	PRKCB/JUN/PRKCA/CALM2/GRIN2C	0.489716107058216
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/550	101/9376	1.18149414941494	WNT2/GNAI2/PRKCB/PRKCA/KITLG/PLCB1/CALM2	0.457774270229313
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/550	38/9376	1.34583732057416	PTPRC/CD4/JAK3	0.533238800324102
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/550	70/9376	1.21766233766234	CD36/TNFRSF1B/SOCS3/NFKB1/TNFRSF1A	0.456284594973946
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/550	23/9376	1.48237154150198	ATP1B1/ATP1B3	0.578169463107472
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/550	71/9376	1.20051216389245	CGA/CCND2/SOCS3/NFKB1/TNFRSF11A	0.423347238163007
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/550	56/9376	1.21766233766234	ST6GAL1/MAN1A1/DAD1/KRTCAP2	0.407806710480718
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/550	105/9376	1.13648484848485	RPS27A/UBB/UBA52/TOMM7/JUN/GABARAP/PRKN	0.351075741959842
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/550	73/9376	1.16762141967621	BST2/CD4/BICD1/FEZ1/SERINC5	0.358892560223735
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/550	90/9376	1.13648484848485	CD28/CD4/JUN/TLR4/NFATC2/NFKB1	0.324770353790479
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/550	41/9376	1.24736141906874	MMP2/RB1/MMP1	0.396234012439152
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/550	42/9376	1.21766233766234	IDO2/INMT/IDO1	0.352906012410559
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/550	10/9376	1.70472727272727	SELENBP1	0.556581828933859
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	9/550	142/9376	1.0804609475032	RPS27A/UBB/UBA52/WWP1/ELOB/PIAS2/SOCS3/UBE2W/PRKN	0.241167844047962
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	7/550	109/9376	1.0947789824854	CD4/JUN/RUNX1/NFATC2/NFKB1/IL2RA/JAK3	0.248450989536413
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	7/550	109/9376	1.0947789824854	CD36/PRKCB/SLC27A4/SOCS3/TBC1D4/NFKB1/TNFRSF1A	0.248450989536413
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/550	43/9376	1.18934460887949	CD36/PLPP3/SLC27A4	0.310642991937067
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/550	77/9376	1.10696576151122	RB1/RAC2/PLD1/NFKB1/CDK6	0.235264850911777
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/550	44/9376	1.16231404958678	MAN1A1/DAD1/KRTCAP2	0.269389154805168
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	11/550	180/9376	1.04177777777778	CCL2/B2M/HLA-C/BST2/HLA-A/SYK/SOCS3/HLA-E/POU2F2/NFKB1/TNFRSF1A	0.141275589493652
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	14/550	232/9376	1.02871473354232	TMSB4X/ACTB/ITGB2/NCKAP1L/FGF7/ARPC3/RAC2/VAV1/ARPC1B/PDGFC/MYL12A/CFL1/MSN/ITGAM	0.1105517688466
NA	NA	hsa04519	Cadherin signaling	24/550	404/9376	1.01270927092709	WNT2/CDH11/ACTB/PRICKLE1/PCDH10/GJA1/NCKAP1L/VIM/ARPC3/PCDH12/SCN1B/PCDH18/RAC2/VAV1/CDH5/KDR/ARPC1B/PCDH11X/NFKB1/MYO1F/LRP6/TMC8/KRT1/EVL	0.0651856062931458
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/550	29/9376	1.17567398119122	GNGT1/CALM2	0.236513177379388
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/550	12/9376	1.42060606060606	CD209	0.363932187717106
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/550	98/9376	1.04371057513915	ITPR2/PRKCB/PRKCA/INPP5D/PLCB1/CALM2	0.108581889816218
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/550	30/9376	1.13648484848485	FOLR2/NFKB1	0.186903400248473
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/550	170/9376	1.0027807486631	HGF/WNT2/ACTB/PRKCB/RB1/PRKCA/GSTA4/MGST2/LRP6/CDK6	0.00913346847067033
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/550	31/9376	1.09982404692082	SRP14/SEC61G	0.138966905842501
NA	NA	hsa04981	Folate transport and metabolism	2/550	31/9376	1.09982404692082	FOLR2/SLCO2B1	0.138966905842501
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/550	32/9376	1.06545454545455	GABARAP/ATG7	0.0925834599729564
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/550	191/9376	0.981780104712042	GNG2/GNG11/HDAC9/GNAI2/GNGT1/GNG10/GNB4/HDAC8/CALM2/GRIN2C/GNG5	-0.063505011848899
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	8/550	139/9376	0.981137998691956	HSPA1A/MMP2/GNAI2/ITPR2/JUN/KCNJ5/PLCB1/CALM2	-0.0559261238790017
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/550	51/9376	1.0027807486631	ENPP2/PLPP3/PLD1	0.00497058410045204
Cellular Processes	Cell motility	hsa04814	Motor proteins	11/550	194/9376	0.96659793814433	ACTB/TUBA1B/MYL6/MYO5A/MYL12A/DYNLL1/MYO1F/DCTN4/CAPZA2/KIF1B/TPM3	-0.117352006083813
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/550	70/9376	0.97412987012987	HPGDS/SULT1A1/GSTA4/MGST2	-0.0542314387343736
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	6/550	106/9376	0.964939965694683	FOLR2/IGF1/RB1/PDGFC/ETV5/NFKB1	-0.0906171551314367
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/550	110/9376	0.929851239669421	DCN/BMP5/PITX2/BMP4/FMOD/GREM2	-0.184737565707837
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/550	17/9376	1.0027807486631	INMT	0.00286455058299553
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/550	17/9376	1.0027807486631	CA8	0.00286455058299553
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/550	37/9376	0.921474201474202	NCOA4/TPM3	-0.119467027264205
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/550	94/9376	0.906769825918762	CCL2/S100A9/JUN/MMP1/NFKB1	-0.22676950981684
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/550	168/9376	0.913246753246753	CSH1/IL12RB2/CCND2/PIAS2/SOCS3/CSHL1/IL10RA/IL2RA/JAK3	-0.283232277286849
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/550	38/9376	0.897224880382775	ENPP1/NAMPT	-0.158466649570582
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/550	77/9376	0.885572609208973	RB1/RUNX1/NFKB1/CDK6	-0.251676262145357
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/550	20/9376	0.852363636363636	NPL	-0.164986440290499
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/550	21/9376	0.811774891774892	CHSY3	-0.215551142126094
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/550	21/9376	0.811774891774892	ENPP1	-0.215551142126094
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/550	22/9376	0.774876033057851	HNMT	-0.263887860433624
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/550	44/9376	0.774876033057851	DYNLL1/DCTN4	-0.373633430595354
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/550	65/9376	0.786797202797203	ITPR2/AGTR1/PLCB1	-0.430562730592866
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	8/550	163/9376	0.836675962074735	PRKCB/JUN/RB1/PRKCA/TLR4/NFATC2/NFKB1/JAK3	-0.525083530485425
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	7/550	144/9376	0.828686868686869	RBPJ/ITPR2/PRKCB/PRKCA/PLCB1/SLC25A5/GRIN2C	-0.517141061873518
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/550	86/9376	0.792896405919662	AREG/PRKCB/JUN/PRKCA	-0.481630549059223
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/550	66/9376	0.774876033057851	HSD17B2/HSD17B1/HSD11B2	-0.458145981469876
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/550	107/9376	0.79660152931181	ITPR2/LDHB/PDE3B/PLCB1/CALM2	-0.528211865033637
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	19/550	370/9376	0.875400491400491	KISS1/CGA/CSH1/SPX/TAC3/LPAR6/HRH1/AGTR1/NPB/TSPO/P2RY1/LYPD6/C3AR1/PTAFR/CSHL1/OGFRL1/HRH2/GRIN2C/CCK	-0.610430523544961
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/550	46/9376	0.741185770750988	FTL/BLVRB	-0.43924948899091
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	7/550	148/9376	0.806289926289926	WNT2/IGF1/JUN/RB1/FGF7/LRP6/CDK6	-0.592944837957678
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/550	168/9376	0.811774891774892	FTL/CYBB/PYCARD/NLRP3/TLR4/SLC25A5/JAK3/TNFRSF1A	-0.614517934951707
NA	NA	hsa03272	Virion - Hepatitis viruses	2/550	48/9376	0.71030303030303	CD63/CD81	-0.502290915785522
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/550	70/9376	0.730597402597403	HGF/JUN/ELOB	-0.564747472442693
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/550	49/9376	0.695807050092764	ST6GAL1/GXYLT2	-0.532919016191666
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/550	50/9376	0.681890909090909	LAP3/GATM	-0.562987041371066
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/550	50/9376	0.681890909090909	CD86/CD28	-0.562987041371066
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/550	27/9376	0.631380471380471	HMGCLL1	-0.478809394599397
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/550	27/9376	0.631380471380471	ELOVL2	-0.478809394599397
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/550	73/9376	0.700572851805728	HPGDS/GSTA4/MGST2	-0.641100499109917
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/550	155/9376	0.769876832844575	WNT2/GNAI2/ITPR2/RB1/AGTR1/PLCB1/CDK6	-0.721144344575645
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/550	28/9376	0.608831168831169	ELOVL2	-0.517450638959043
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	7/550	156/9376	0.764941724941725	CD81/RB1/SOCS3/EIF3E/NFKB1/TNFRSF1A/CDK6	-0.739022064203733
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	7/550	157/9376	0.760069484655472	BMP5/WNT2/ACTB/AREG/CCND2/ITGB2/BMP4	-0.756795301179888
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/550	75/9376	0.681890909090909	IGF1/CCND2/CDK6	-0.690441538212541
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	10/550	217/9376	0.785588604943444	GNAI2/PRKCB/JUN/RB1/FGF7/PRKCA/ARRB2/GSTA4/MGST2/NFKB1	-0.797698400723557
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/550	29/9376	0.587836990595611	RASSF4	-0.554902793751641
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/550	99/9376	0.688778696051423	IGF1/MMP2/JUN/RB1	-0.777084342387499
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/550	120/9376	0.71030303030303	JUN/NFKB1/SH2B3/CALM2/MAP2K5	-0.797274591763508
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/550	55/9376	0.619900826446281	PLPP3/ASAH1	-0.705719369545317
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/550	78/9376	0.655664335664336	INPP5D/PLCB1/PIK3CG	-0.762288834583417
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/550	31/9376	0.549912023460411	KL	-0.626575814004322
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/550	79/9376	0.647364787111623	HPGDS/GSTA4/MGST2	-0.785692900295228
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/550	32/9376	0.532727272727273	LDHB	-0.660943033695827
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/550	32/9376	0.532727272727273	TNFRSF1A	-0.660943033695827
Human Diseases	Immune disease	hsa05310	Asthma	1/550	32/9376	0.532727272727273	FCER1G	-0.660943033695827
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/550	33/9376	0.516584022038567	VAMP5	-0.69441615792031
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/550	82/9376	0.623680709534368	GSTA4/MGST2/NME2	-0.854372172675189
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/550	59/9376	0.577873651771957	ENPP1/NME2	-0.811924114262914
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/550	34/9376	0.501390374331551	POLR2L	-0.727051553511558
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/550	169/9376	0.706100053792362	RPS27A/UBB/UBA52/GABARAP/ATG7/CTSB/TANK	-0.962429239282501
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/550	150/9376	0.681890909090909	HGF/WNT2/RARB/RB1/FGF7/LRP6	-0.980392558867963
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/550	85/9376	0.601668449197861	ENPP1/NME2/APRT	-0.920890433306543
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/550	62/9376	0.549912023460411	IGF1/HSPA1A	-0.887585422521817
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/550	36/9376	0.473535353535354	KL	-0.790009013064681
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/550	36/9376	0.473535353535354	ENPP1	-0.790009013064681
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/550	86/9376	0.594672304439746	SCN9A/P2RY1/PLCB1	-0.942611360408679
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/550	63/9376	0.541183261183261	WNT2/BMP4	-0.912115315987553
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	7/550	174/9376	0.685809822361547	HSPA1A/MAN1A1/SSR4/SEC61G/DAD1/PRKN/KRTCAP2	-1.04426599211003
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/550	87/9376	0.587836990595611	AREG/JUN/RAC2	-0.964115752148191
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/550	65/9376	0.524531468531468	PLPP3/GK	-0.960207989322689
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/550	90/9376	0.568242424242424	IGF1/NFKB1/KL	-1.02738188294999
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/550	138/9376	0.617654808959157	RPS6/MKNK1/PDE3B/SOCS3/CALM2	-1.12951295863546
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/550	41/9376	0.415787139689579	GATM	-0.9358169379479
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/550	41/9376	0.415787139689579	GRIN2C	-0.9358169379479
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/550	72/9376	0.473535353535354	NFKB1/TANK	-1.11940084702067
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/550	144/9376	0.591919191919192	WNT2/IGF1/BMP4/DUSP9/JAK3	-1.23186903889682
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/550	46/9376	0.370592885375494	PSMB8	-1.06820538526134
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/550	75/9376	0.454593939393939	GSTA4/MGST2	-1.18377943352429
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/550	47/9376	0.362707930367505	LDHB	-1.09333919670881
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/550	47/9376	0.362707930367505	SOCS3	-1.09333919670881
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/550	48/9376	0.355151515151515	HMGCLL1	-1.11807015563974
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/550	104/9376	0.491748251748252	PLPP3/PLD1/PHOSPHO1	-1.30104962162803
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	4/550	133/9376	0.5126999316473	IGF1/KLF2/CCND2/GABARAP	-1.41286555595554
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/550	110/9376	0.464925619834711	IGF1/GNAI2/PDE3B	-1.40912452334922
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/550	54/9376	0.315690235690236	LDHB	-1.25886769523569
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/550	57/9376	0.299074960127592	ELOVL2	-1.32498013893394
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/550	90/9376	0.378828282828283	ATP1B1/ATP1B3	-1.47809929519681
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/550	62/9376	0.274956011730205	RBPJ	-1.42980596732013
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/550	63/9376	0.270591630591631	PRDM6	-1.45004418771351
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/550	63/9376	0.270591630591631	POLR2L	-1.45004418771351
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/550	67/9376	0.254436906377205	LDHB	-1.52881631708994
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/550	158/9376	0.431576524741082	CCND2/RB1/HDAC8/CDK6	-1.79873513745039
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/550	71/9376	0.240102432778489	LDHB	-1.60439411816719
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/550	138/9376	0.370592885375494	IGF1/ITPR2/CALM2	-1.85937605306455
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/550	78/9376	0.218554778554779	BTG3	-1.72996011986017
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	10/550	323/9376	0.527779341401632	ZEB2/MARCKS/CCND2/PRKCB/VIM/PRKCA/FSCN1/NFKB1/CDK6/TNXB	-2.15593173314289
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/550	83/9376	0.20538882803943	HMGCLL1	-1.81510087356048
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/550	122/9376	0.27946348733234	CD36/IGF1	-1.99966010630641
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/550	154/9376	0.332089728453365	IDO2/NME2/IDO1	-2.08617600191564
NA	NA	hsa04382	Cornified envelope formation	5/550	217/9376	0.392794302471722	S100A9/S100A4/S100A6/SLC27A4/KRT1	-2.25905443925112
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/550	108/9376	0.157845117845118	SUMO2	-2.19733289466024
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/550	117/9376	0.145703185703186	ACTB	-2.32115796485341
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/550	183/9376	0.0931544957774466	NOP10	-3.0925393934917
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/550	243/9376	0.0701533857089413	HSPA1A	-3.66600238736407
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/550	449/9376	0.189835999190119	PRKG1/SLC8A1/ARRB2/GRK3/CALM2	-4.39165652397331