ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 71/844 175/18639 0.405714285714286 8.95984427894381 3.33514437116147e-49 3.14837628637643e-46 GO:0022853 active monoatomic ion transmembrane transporter activity 30/844 118/18639 0.254237288135593 5.61460759900394 6.12003030479723e-15 2.8886543038643e-12 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 22/844 68/18639 0.323529411764706 7.14486339559521 1.14163740020252e-13 3.59235235263727e-11 GO:0015078 proton transmembrane transporter activity 35/844 185/18639 0.189189189189189 4.17807736646599 4.87247933243941e-13 1.1499051224557e-10 GO:0005201 extracellular matrix structural constituent 33/844 168/18639 0.196428571428571 4.33795277589709 7.59275489637483e-13 1.43351212443557e-10 GO:0009055 electron transfer activity 26/844 116/18639 0.224137931034483 4.94988968785749 9.04877765890461e-12 1.42367435166766e-09 GO:0015399 primary active transmembrane transporter activity 30/844 166/18639 0.180722891566265 3.99110660652087 7.48228204409198e-11 1.00903917851755e-08 GO:0004129 cytochrome-c oxidase activity 9/844 15/18639 0.6 13.2504739336493 3.00433227405381e-09 3.5451120833835e-07 GO:0016675 oxidoreductase activity, acting on a heme group of donors 9/844 16/18639 0.5625 12.4223193127962 6.5906776417842e-09 6.91288854871588e-07 GO:0005178 integrin binding 25/844 161/18639 0.15527950310559 3.42921168055106 6.7073433172457e-08 6.33173209147994e-06 GO:1990948 ubiquitin ligase inhibitor activity 7/844 11/18639 0.636363636363636 14.0535329599311 1.07154586507024e-07 9.19581178751185e-06 GO:0019843 rRNA binding 15/844 65/18639 0.230769230769231 5.09633612832665 1.51759926839471e-07 1.19384475780384e-05 GO:0038024 cargo receptor activity 14/844 65/18639 0.215384615384615 4.75658038643821 9.68523130672847e-07 7.03296796427052e-05 GO:0055105 ubiquitin-protein transferase inhibitor activity 7/844 15/18639 0.466666666666667 10.3059241706161 1.78083182965216e-06 0.000120078946227974 GO:0030695 GTPase regulator activity 46/844 489/18639 0.0940695296523517 2.07744308434856 2.34214543168849e-06 0.000146042474906767 GO:0060589 nucleoside-triphosphatase regulator activity 46/844 490/18639 0.0938775510204082 2.07320340458458 2.47529618486045e-06 0.000146042474906767 GO:0003954 NADH dehydrogenase activity 11/844 44/18639 0.25 5.5210308056872 2.9889261857077e-06 0.000165973312900475 GO:0019838 growth factor binding 20/844 136/18639 0.147058823529412 3.247665179816 3.23557106238916e-06 0.00016968772682752 GO:0022804 active transmembrane transporter activity 43/844 457/18639 0.0940919037199125 2.07793719601356 4.9599583992717e-06 0.00023729759511868 GO:0005539 glycosaminoglycan binding 28/844 242/18639 0.115702479338843 2.55518781089656 5.26418352183144e-06 0.00023729759511868 GO:0001664 G protein-coupled receptor binding 32/844 297/18639 0.107744107744108 2.379434151946 5.27886599310623e-06 0.00023729759511868 GO:0038187 pattern recognition receptor activity 11/844 48/18639 0.229166666666667 5.06094490521327 7.46076409527881e-06 0.0003201346048156 GO:0008137 NADH dehydrogenase (ubiquinone) activity 10/844 41/18639 0.24390243902439 5.38637151774361 1.07163565397789e-05 0.000439836546676141 GO:0030020 extracellular matrix structural constituent conferring tensile strength 10/844 44/18639 0.227272727272727 5.01911891426109 2.09672619833565e-05 0.00082471230467869 GO:0031386 protein tag activity 6/844 15/18639 0.4 8.83364928909953 2.98115790803467e-05 0.00108238964045566 GO:0141047 molecular tag activity 6/844 15/18639 0.4 8.83364928909953 2.98115790803467e-05 0.00108238964045566 GO:0004857 enzyme inhibitor activity 38/844 416/18639 0.0913461538461538 2.01729971746263 3.36291575161892e-05 0.00117577498871417 GO:0031720 haptoglobin binding 5/844 10/18639 0.5 11.0420616113744 3.91937236167228e-05 0.00132138839622094 GO:0048027 mRNA 5'-UTR binding 7/844 24/18639 0.291666666666667 6.44120260663507 6.69498604421082e-05 0.00217666642044629 GO:0019864 IgG binding 5/844 11/18639 0.454545454545455 10.0382378285222 6.91737209887594e-05 0.00217666642044629 GO:0019955 cytokine binding 18/844 144/18639 0.125 2.7605154028436 9.09500749065402e-05 0.00276957647457335 GO:0016209 antioxidant activity 13/844 86/18639 0.151162790697674 3.33829769646203 0.0001249483347053 0.00364007926646106 GO:0005085 guanyl-nucleotide exchange factor activity 24/844 230/18639 0.104347826086957 2.30443024933031 0.000127248533679253 0.00364007926646106 GO:0005044 scavenger receptor activity 7/844 27/18639 0.259259259259259 5.72551342812006 0.000152525154902011 0.00423481606551467 GO:0016651 oxidoreductase activity, acting on NAD(P)H 13/844 88/18639 0.147727272727273 3.26242729426971 0.000158598320918695 0.00427762328420708 GO:0035325 Toll-like receptor binding 5/844 13/18639 0.384615384615385 8.49389354721108 0.000178607930202125 0.00455691584083258 GO:0070700 BMP receptor binding 5/844 13/18639 0.384615384615385 8.49389354721108 0.000178607930202125 0.00455691584083258 GO:0050840 extracellular matrix binding 11/844 67/18639 0.164179104477612 3.62575157388413 0.000193679024354236 0.00481139471027366 GO:0017124 SH3 domain binding 15/844 115/18639 0.130434782608696 2.88053781166289 0.000213542182096327 0.00493343204938425 GO:0004601 peroxidase activity 10/844 57/18639 0.175438596491228 3.87440758293839 0.000214269824178765 0.00493343204938425 GO:0016504 peptidase activator activity 10/844 57/18639 0.175438596491228 3.87440758293839 0.000214269824178765 0.00493343204938425 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 10/844 58/18639 0.172413793103448 3.80760745219807 0.00024855030805075 0.00553310980627511 GO:0061134 peptidase regulator activity 23/844 226/18639 0.101769911504425 2.24749926603196 0.000252037840751938 0.00553310980627511 GO:0005344 oxygen carrier activity 5/844 14/18639 0.357142857142857 7.88718686526743 0.000267501624658822 0.0056115896372873 GO:0019763 immunoglobulin receptor activity 5/844 14/18639 0.357142857142857 7.88718686526743 0.000267501624658822 0.0056115896372873 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 10/844 59/18639 0.169491525423729 3.74307173266929 0.000287305931078018 0.00589601736820975 GO:0005126 cytokine receptor binding 26/844 275/18639 0.0945454545454545 2.08795346833262 0.000332272887328906 0.00667373629018057 GO:0001540 amyloid-beta binding 12/844 83/18639 0.144578313253012 3.1928852852167 0.000344776407374267 0.00678060267836058 GO:0044325 transmembrane transporter binding 16/844 136/18639 0.117647058823529 2.5981321438528 0.00043963703308565 0.00846974202516027 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 6/844 24/18639 0.25 5.5210308056872 0.000564997753104442 0.0106671575786119 GO:0005031 tumor necrosis factor receptor activity 4/844 10/18639 0.4 8.83364928909953 0.000704071546287756 0.013032226268542 GO:0030169 low-density lipoprotein particle binding 5/844 17/18639 0.294117647058824 6.495330359632 0.000738158445553665 0.0134004148577435 GO:1901681 sulfur compound binding 25/844 275/18639 0.0909090909090909 2.00764756570444 0.000762905357595292 0.0135883520296218 GO:0008201 heparin binding 18/844 172/18639 0.104651162790698 2.31112917447371 0.000823580993118303 0.0142515704348572 GO:0008009 chemokine activity 8/844 45/18639 0.177777777777778 3.9260663507109 0.000830335141861385 0.0142515704348572 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 5/844 18/18639 0.277777777777778 6.13447867298578 0.000984231067628101 0.0165913237114451 GO:0055106 ubiquitin-protein transferase regulator activity 7/844 36/18639 0.194444444444444 4.29413507109005 0.00100524309377504 0.0166482365004147 GO:0001851 complement component C3b binding 4/844 11/18639 0.363636363636364 8.03059026281775 0.00106687030360147 0.0167854261099964 GO:0048407 platelet-derived growth factor binding 4/844 11/18639 0.363636363636364 8.03059026281775 0.00106687030360147 0.0167854261099964 GO:0097493 structural molecule activity conferring elasticity 4/844 11/18639 0.363636363636364 8.03059026281775 0.00106687030360147 0.0167854261099964 GO:0043394 proteoglycan binding 7/844 37/18639 0.189189189189189 4.17807736646599 0.00119201653897526 0.0184469444720106 GO:0005518 collagen binding 10/844 72/18639 0.138888888888889 3.06723933649289 0.0014448708874252 0.0219993244795062 GO:0015026 coreceptor activity 9/844 61/18639 0.147540983606557 3.25831326237278 0.00160354756929632 0.0240277604034242 GO:0033612 receptor serine/threonine kinase binding 6/844 30/18639 0.2 4.41682464454976 0.00197709439412182 0.0291621423132969 GO:0001846 opsonin binding 5/844 21/18639 0.238095238095238 5.25812457684496 0.00208802609830511 0.0303245636430773 GO:0005035 death receptor activity 4/844 13/18639 0.307692307692308 6.79511483776887 0.00214971977895266 0.0307475071413835 GO:0005125 cytokine activity 21/844 234/18639 0.0897435897435897 1.98190849434925 0.00227476493441 0.0320504193743737 GO:0030021 extracellular matrix structural constituent conferring compression resistance 5/844 22/18639 0.227272727272727 5.01911891426109 0.00260260777113486 0.0356066918253812 GO:0061133 endopeptidase activator activity 5/844 22/18639 0.227272727272727 5.01911891426109 0.00260260777113486 0.0356066918253812 GO:0071813 lipoprotein particle binding 6/844 32/18639 0.1875 4.1407731042654 0.00279395733782778 0.036739310195281 GO:0071814 protein-lipid complex binding 6/844 32/18639 0.1875 4.1407731042654 0.00279395733782778 0.036739310195281 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 8/844 54/18639 0.148148148148148 3.27172195892575 0.00280215077760618 0.036739310195281 GO:0046332 SMAD binding 10/844 79/18639 0.126582278481013 2.79545863579099 0.00292397234180973 0.0377311992778775 GO:0005096 GTPase activator activity 23/844 271/18639 0.0848708487084871 1.8742982808975 0.0029577423162743 0.0377311992778775 GO:0031681 G-protein beta-subunit binding 5/844 23/18639 0.217391304347826 4.80089635277148 0.00320319721313374 0.04031757558931 GO:0140311 protein sequestering activity 6/844 33/18639 0.181818181818182 4.01529513140888 0.00328618491976091 0.0408178758454513 GO:0005041 low-density lipoprotein particle receptor activity 4/844 15/18639 0.266666666666667 5.88909952606635 0.00381761082002369 0.0443277404350698 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 5/844 24/18639 0.208333333333333 4.60085900473934 0.00389746022893093 0.0443277404350698 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 5/844 24/18639 0.208333333333333 4.60085900473934 0.00389746022893093 0.0443277404350698 GO:0005540 hyaluronic acid binding 5/844 24/18639 0.208333333333333 4.60085900473934 0.00389746022893093 0.0443277404350698 GO:0042625 ATPase-coupled ion transmembrane transporter activity 5/844 24/18639 0.208333333333333 4.60085900473934 0.00389746022893093 0.0443277404350698 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 5/844 24/18639 0.208333333333333 4.60085900473934 0.00389746022893093 0.0443277404350698 GO:0046961 proton-transporting ATPase activity, rotational mechanism 5/844 24/18639 0.208333333333333 4.60085900473934 0.00389746022893093 0.0443277404350698 GO:0061135 endopeptidase regulator activity 17/844 184/18639 0.0923913043478261 2.04038094992788 0.00425545267416321 0.0477736452703541 GO:0033218 amide binding 21/844 247/18639 0.0850202429149798 1.87759752096245 0.00430165238133485 0.0477736452703541 GO:0001848 complement binding 5/844 25/18639 0.2 4.41682464454976 0.00469302634456741 0.0515141496426934 GO:0005324 long-chain fatty acid transmembrane transporter activity 4/844 16/18639 0.25 5.5210308056872 0.00490977866876879 0.05327392026802 GO:0020037 heme binding 14/844 142/18639 0.0985915492957746 2.1773079233696 0.0051290087558175 0.0550202757442241 GO:0031625 ubiquitin protein ligase binding 24/844 302/18639 0.0794701986754967 1.755029660086 0.00556792236538223 0.058065746464006 GO:0004112 cyclic-nucleotide phosphodiesterase activity 5/844 26/18639 0.192307692307692 4.24694677360554 0.00559743954261075 0.058065746464006 GO:0019865 immunoglobulin binding 5/844 26/18639 0.192307692307692 4.24694677360554 0.00559743954261075 0.058065746464006 GO:0008081 phosphoric diester hydrolase activity 10/844 87/18639 0.114942528735632 2.53840496813205 0.00588059252500369 0.0603399928652552 GO:0015278 intracellularly gated calcium channel activity 4/844 17/18639 0.235294117647059 5.1962642877056 0.00619335412206575 0.0628658740992481 GO:0004364 glutathione transferase activity 5/844 27/18639 0.185185185185185 4.08965244865719 0.00661811190926696 0.0657631330773474 GO:0015252 proton channel activity 5/844 27/18639 0.185185185185185 4.08965244865719 0.00661811190926696 0.0657631330773474 GO:0030228 lipoprotein particle receptor activity 4/844 18/18639 0.222222222222222 4.90758293838863 0.00768167499476221 0.0747577442789229 GO:0035615 clathrin adaptor activity 4/844 18/18639 0.222222222222222 4.90758293838863 0.00768167499476221 0.0747577442789229 GO:0005080 protein kinase C binding 7/844 52/18639 0.134615384615385 2.97286274152388 0.00862312637422262 0.0825096658273642 GO:0005131 growth hormone receptor binding 3/844 10/18639 0.3 6.62523696682464 0.0087404307020513 0.0825096658273642 GO:0043422 protein kinase B binding 3/844 10/18639 0.3 6.62523696682464 0.0087404307020513 0.0825096658273642 GO:0003785 actin monomer binding 5/844 29/18639 0.172413793103448 3.80760745219807 0.0090369668403685 0.0844643237357214 GO:0046906 tetrapyrrole binding 14/844 152/18639 0.0921052631578947 2.03406398104265 0.00921593142530982 0.0852925418185536 GO:0015245 fatty acid transmembrane transporter activity 4/844 19/18639 0.210526315789474 4.64928909952607 0.00938709361486311 0.0860331686643764 GO:0042277 peptide binding 20/844 249/18639 0.0803212851405622 1.77382515845372 0.00963322888581442 0.0874400775789309 GO:0001618 virus receptor activity 9/844 81/18639 0.111111111111111 2.45379146919431 0.0108499484329991 0.0975462030547725 GO:0004713 protein tyrosine kinase activity 13/844 140/18639 0.0928571428571429 2.05066858496953 0.0111023933035432 0.0986193010936449 GO:0003779 actin binding 31/844 443/18639 0.0699774266365688 1.54539011265285 0.011178247051928 0.0986193010936449 GO:0008046 axon guidance receptor activity 3/844 11/18639 0.272727272727273 6.02294269711331 0.01161801585147 0.0987272083558191 GO:0042608 T cell receptor binding 3/844 11/18639 0.272727272727273 6.02294269711331 0.01161801585147 0.0987272083558191 GO:0140031 phosphorylation-dependent protein binding 3/844 11/18639 0.272727272727273 6.02294269711331 0.01161801585147 0.0987272083558191 GO:0140313 molecular sequestering activity 7/844 55/18639 0.127272727272727 2.81070659198621 0.011644394449942 0.0987272083558191 GO:0140272 exogenous protein binding 9/844 82/18639 0.109756097560976 2.42386718298463 0.0117133976015379 0.0987272083558191 GO:0044389 ubiquitin-like protein ligase binding 24/844 322/18639 0.0745341614906832 1.64602160666451 0.0118348392588209 0.0988680377020079 GO:0070325 lipoprotein particle receptor binding 5/844 31/18639 0.161290322580645 3.56195535850787 0.0120046889625226 0.0994072489528184 GO:0140312 cargo adaptor activity 4/844 21/18639 0.19047619047619 4.20649966147596 0.0134933613182387 0.110117061780663 GO:0097110 scaffold protein binding 8/844 70/18639 0.114285714285714 2.52389979688558 0.0135313338628781 0.110117061780663 GO:0140297 DNA-binding transcription factor binding 33/844 488/18639 0.0676229508196721 1.49339357858752 0.0144752394308525 0.116791675407904 GO:0035497 cAMP response element binding 3/844 12/18639 0.25 5.5210308056872 0.0149762798601297 0.118803430150945 GO:0097371 MDM2/MDM4 family protein binding 3/844 12/18639 0.25 5.5210308056872 0.0149762798601297 0.118803430150945 GO:0004715 non-membrane spanning protein tyrosine kinase activity 6/844 45/18639 0.133333333333333 2.94454976303318 0.0152909126936816 0.120288513190296 GO:0008083 growth factor activity 14/844 162/18639 0.0864197530864197 1.90850447604002 0.0155187086935703 0.12107157856802 GO:0042379 chemokine receptor binding 8/844 72/18639 0.111111111111111 2.45379146919431 0.0158636951453091 0.122748591944031 GO:0030246 carbohydrate binding 21/844 280/18639 0.075 1.65630924170616 0.0166529827627182 0.127808257951268 GO:0004180 carboxypeptidase activity 6/844 46/18639 0.130434782608696 2.88053781166289 0.0169310105127711 0.127862991392448 GO:0030276 clathrin binding 6/844 46/18639 0.130434782608696 2.88053781166289 0.0169310105127711 0.127862991392448 GO:1990782 protein tyrosine kinase binding 11/844 117/18639 0.094017094017094 2.07628508931826 0.0170905117397178 0.128043199065822 GO:0019825 oxygen binding 5/844 34/18639 0.147058823529412 3.247665179816 0.0175945436758997 0.12975975960976 GO:0051427 hormone receptor binding 5/844 34/18639 0.147058823529412 3.247665179816 0.0175945436758997 0.12975975960976 GO:0004602 glutathione peroxidase activity 4/844 23/18639 0.173913043478261 3.84071708221718 0.0185893880489437 0.132612611962326 GO:0016849 phosphorus-oxygen lyase activity 4/844 23/18639 0.173913043478261 3.84071708221718 0.0185893880489437 0.132612611962326 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 4/844 23/18639 0.173913043478261 3.84071708221718 0.0185893880489437 0.132612611962326 GO:0005504 fatty acid binding 6/844 47/18639 0.127659574468085 2.81924977311687 0.0186881851795877 0.132612611962326 GO:0017154 semaphorin receptor activity 3/844 13/18639 0.230769230769231 5.09633612832665 0.0188242478844828 0.132612611962326 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 3/844 13/18639 0.230769230769231 5.09633612832665 0.0188242478844828 0.132612611962326 GO:0019210 kinase inhibitor activity 9/844 90/18639 0.1 2.20841232227488 0.0205699703921489 0.143583361437179 GO:0002020 protease binding 12/844 136/18639 0.0882352941176471 1.9485991078896 0.0206857385121359 0.143583361437179 GO:0005161 platelet-derived growth factor receptor binding 3/844 14/18639 0.214285714285714 4.73231211916046 0.0231665135691589 0.159629115396248 GO:0048020 CCR chemokine receptor binding 6/844 50/18639 0.12 2.65009478672986 0.024696072305721 0.167829483237113 GO:0120020 cholesterol transfer activity 4/844 25/18639 0.16 3.53345971563981 0.0247343921402565 0.167829483237113 GO:0051219 phosphoprotein binding 9/844 93/18639 0.0967741935483871 2.13717321510472 0.0248899657343176 0.167829483237113 GO:0140375 immune receptor activity 13/844 156/18639 0.0833333333333333 1.84034360189573 0.0251116180692375 0.168123173456455 GO:0005021 vascular endothelial growth factor receptor activity 6/844 51/18639 0.117647058823529 2.5981321438528 0.0269545249048025 0.17919064443756 GO:0005109 frizzled binding 5/844 38/18639 0.131578947368421 2.90580568720379 0.0273932175978482 0.180833548338243 GO:0016846 carbon-sulfur lyase activity 3/844 15/18639 0.2 4.41682464454976 0.0280037392564427 0.183580068458902 GO:0050750 low-density lipoprotein particle receptor binding 4/844 26/18639 0.153846153846154 3.39755741888443 0.0282138380671012 0.183681814726507 GO:0051015 actin filament binding 16/844 209/18639 0.076555023923445 1.69065058164584 0.0285071494871072 0.184320199423488 GO:0045296 cadherin binding 23/844 334/18639 0.0688622754491018 1.52076297641683 0.0307268286333421 0.197320586597788 GO:0023026 MHC class II protein complex binding 4/844 27/18639 0.148148148148148 3.27172195892575 0.0319696165293333 0.203914310835747 GO:0005521 lamin binding 3/844 16/18639 0.1875 4.1407731042654 0.0333331147766752 0.20838715463034 GO:0015923 mannosidase activity 3/844 16/18639 0.1875 4.1407731042654 0.0333331147766752 0.20838715463034 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 3/844 16/18639 0.1875 4.1407731042654 0.0333331147766752 0.20838715463034 GO:0016798 hydrolase activity, acting on glycosyl bonds 11/844 130/18639 0.0846153846153846 1.86865658038644 0.0340072727091807 0.211203062088596 GO:0035401 histone H3Y41 kinase activity 10/844 115/18639 0.0869565217391304 1.92035854110859 0.0358337031983655 0.217551970488672 GO:0140801 histone H2AXY142 kinase activity 10/844 115/18639 0.0869565217391304 1.92035854110859 0.0358337031983655 0.217551970488672 GO:0046875 ephrin receptor binding 4/844 28/18639 0.142857142857143 3.15487474610697 0.0360041725515037 0.217551970488672 GO:0004860 protein kinase inhibitor activity 8/844 84/18639 0.0952380952380952 2.10324983073798 0.0362167571015713 0.217551970488672 GO:0051117 ATPase binding 8/844 84/18639 0.0952380952380952 2.10324983073798 0.0362167571015713 0.217551970488672 GO:0001530 lipopolysaccharide binding 5/844 41/18639 0.121951219512195 2.69318575887181 0.0366427577412064 0.217551970488672 GO:0042169 SH2 domain binding 5/844 41/18639 0.121951219512195 2.69318575887181 0.0366427577412064 0.217551970488672 GO:0005179 hormone activity 11/844 132/18639 0.0833333333333333 1.84034360189573 0.0373944297589611 0.22062713557787 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/844 17/18639 0.176470588235294 3.8971982157792 0.0391487777740915 0.226726663918665 GO:0019198 transmembrane receptor protein phosphatase activity 3/844 17/18639 0.176470588235294 3.8971982157792 0.0391487777740915 0.226726663918665 GO:0036041 long-chain fatty acid binding 3/844 17/18639 0.176470588235294 3.8971982157792 0.0391487777740915 0.226726663918665 GO:0019208 phosphatase regulator activity 10/844 117/18639 0.0854700854700855 1.88753189938024 0.0396190889682925 0.227910572689996 GO:0042056 chemoattractant activity 5/844 42/18639 0.119047619047619 2.62906228842248 0.040103153001989 0.227910572689996 GO:0170055 lipid transmembrane transporter activity 6/844 56/18639 0.107142857142857 2.36615605958023 0.0402824434301778 0.227910572689996 GO:0099604 ligand-gated calcium channel activity 4/844 29/18639 0.137931034482759 3.04608596175846 0.0403189254652853 0.227910572689996 GO:0048156 tau protein binding 5/844 43/18639 0.116279069767442 2.56792130497079 0.0437552521800129 0.244480756603037 GO:0030414 peptidase inhibitor activity 13/844 169/18639 0.0769230769230769 1.69877870944222 0.0437682710443996 0.244480756603037 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 4/844 30/18639 0.133333333333333 2.94454976303318 0.0449143076400035 0.249406508306843 GO:0070851 growth factor receptor binding 11/844 139/18639 0.079136690647482 1.74766442769955 0.0510919568139234 0.282051504282712 GO:0042605 peptide antigen binding 5/844 45/18639 0.111111111111111 2.45379146919431 0.0516389208559582 0.283413612139678 GO:0043395 heparan sulfate proteoglycan binding 3/844 19/18639 0.157894736842105 3.48696682464455 0.0522025304640375 0.284850802069661 GO:0004714 transmembrane receptor protein tyrosine kinase activity 6/844 60/18639 0.1 2.20841232227488 0.053500471311995 0.290255430566226 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 8/844 91/18639 0.0879120879120879 1.94146138221968 0.0538827057638494 0.290658709948994 GO:0043425 bHLH transcription factor binding 4/844 32/18639 0.125 2.7605154028436 0.0549440105175056 0.29303472276003 GO:0120015 sterol transfer activity 4/844 32/18639 0.125 2.7605154028436 0.0549440105175056 0.29303472276003 GO:0098631 cell adhesion mediator activity 7/844 76/18639 0.0921052631578947 2.03406398104265 0.0561193357760409 0.297621645913385 GO:0043178 alcohol binding 8/844 92/18639 0.0869565217391304 1.92035854110859 0.0567873122653942 0.299481691500179 GO:0001614 purinergic nucleotide receptor activity 3/844 20/18639 0.15 3.31261848341232 0.0594169329257309 0.308184531219175 GO:0016502 nucleotide receptor activity 3/844 20/18639 0.15 3.31261848341232 0.0594169329257309 0.308184531219175 GO:0016505 peptidase activator activity involved in apoptotic process 3/844 20/18639 0.15 3.31261848341232 0.0594169329257309 0.308184531219175 GO:0001784 phosphotyrosine residue binding 5/844 47/18639 0.106382978723404 2.34937481093073 0.0602981890001539 0.311046395716641 GO:0005319 lipid transporter activity 13/844 178/18639 0.0730337078651685 1.61288540390862 0.0613214757182789 0.314605831945953 GO:0004866 endopeptidase inhibitor activity 12/844 161/18639 0.0745341614906832 1.64602160666451 0.0622216242284877 0.317498450117256 GO:0019199 transmembrane receptor protein kinase activity 7/844 78/18639 0.0897435897435897 1.98190849434925 0.0628726559648898 0.319095630273419 GO:0019207 kinase regulator activity 19/844 287/18639 0.0662020905923345 1.46201512624469 0.0636044252493966 0.321083301793745 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/844 21/18639 0.142857142857143 3.15487474610697 0.0670708615269796 0.333236280428783 GO:0009975 cyclase activity 3/844 21/18639 0.142857142857143 3.15487474610697 0.0670708615269796 0.333236280428783 GO:0072542 protein phosphatase activator activity 3/844 21/18639 0.142857142857143 3.15487474610697 0.0670708615269796 0.333236280428783 GO:0043015 gamma-tubulin binding 4/844 35/18639 0.114285714285714 2.52389979688558 0.0720522313370018 0.336725704723016 GO:0005381 iron ion transmembrane transporter activity 2/844 10/18639 0.2 4.41682464454976 0.0724061477430498 0.336725704723016 GO:0005522 profilin binding 2/844 10/18639 0.2 4.41682464454976 0.0724061477430498 0.336725704723016 GO:0008239 dipeptidyl-peptidase activity 2/844 10/18639 0.2 4.41682464454976 0.0724061477430498 0.336725704723016 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/844 10/18639 0.2 4.41682464454976 0.0724061477430498 0.336725704723016 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/844 10/18639 0.2 4.41682464454976 0.0724061477430498 0.336725704723016 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/844 10/18639 0.2 4.41682464454976 0.0724061477430498 0.336725704723016 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/844 10/18639 0.2 4.41682464454976 0.0724061477430498 0.336725704723016 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/844 10/18639 0.2 4.41682464454976 0.0724061477430498 0.336725704723016 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/844 10/18639 0.2 4.41682464454976 0.0724061477430498 0.336725704723016 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/844 10/18639 0.2 4.41682464454976 0.0724061477430498 0.336725704723016 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/844 10/18639 0.2 4.41682464454976 0.0724061477430498 0.336725704723016 GO:0019887 protein kinase regulator activity 17/844 255/18639 0.0666666666666667 1.47227488151659 0.0724102945537843 0.336725704723016 GO:0031072 heat shock protein binding 10/844 131/18639 0.0763358778625954 1.68581093303426 0.0738829853918198 0.34026032621595 GO:0030971 receptor tyrosine kinase binding 7/844 81/18639 0.0864197530864197 1.90850447604002 0.073891278468506 0.34026032621595 GO:0008093 cytoskeletal anchor activity 3/844 22/18639 0.136363636363636 3.01147134855666 0.0751483351196894 0.342705450980612 GO:0140517 protein-RNA adaptor activity 3/844 22/18639 0.136363636363636 3.01147134855666 0.0751483351196894 0.342705450980612 GO:0042626 ATPase-coupled transmembrane transporter activity 8/844 98/18639 0.0816326530612245 1.80278556920398 0.0762771547890529 0.346180933273394 GO:0016247 channel regulator activity 12/844 168/18639 0.0714285714285714 1.57743737305349 0.0799181877465763 0.360970187716593 GO:0005158 insulin receptor binding 3/844 23/18639 0.130434782608696 2.88053781166289 0.0836321771803012 0.366983722592385 GO:0017134 fibroblast growth factor binding 3/844 23/18639 0.130434782608696 2.88053781166289 0.0836321771803012 0.366983722592385 GO:0043274 phospholipase binding 3/844 23/18639 0.130434782608696 2.88053781166289 0.0836321771803012 0.366983722592385 GO:0023023 MHC protein complex binding 4/844 37/18639 0.108108108108108 2.38747278083771 0.0847892337121784 0.366983722592385 GO:0141108 transporter regulator activity 12/844 170/18639 0.0705882352941176 1.55887928631168 0.085503524273197 0.366983722592385 GO:0005225 volume-sensitive anion channel activity 2/844 11/18639 0.181818181818182 4.01529513140888 0.0859146214967342 0.366983722592385 GO:0008271 secondary active sulfate transmembrane transporter activity 2/844 11/18639 0.181818181818182 4.01529513140888 0.0859146214967342 0.366983722592385 GO:0032050 clathrin heavy chain binding 2/844 11/18639 0.181818181818182 4.01529513140888 0.0859146214967342 0.366983722592385 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/844 11/18639 0.181818181818182 4.01529513140888 0.0859146214967342 0.366983722592385 GO:0034713 type I transforming growth factor beta receptor binding 2/844 11/18639 0.181818181818182 4.01529513140888 0.0859146214967342 0.366983722592385 GO:0050786 RAGE receptor binding 2/844 11/18639 0.181818181818182 4.01529513140888 0.0859146214967342 0.366983722592385 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/844 11/18639 0.181818181818182 4.01529513140888 0.0859146214967342 0.366983722592385 GO:0005246 calcium channel regulator activity 5/844 53/18639 0.0943396226415094 2.08340785120272 0.0908756901289592 0.384561227451247 GO:0008238 exopeptidase activity 8/844 102/18639 0.0784313725490196 1.73208809590187 0.0912492114462208 0.384561227451247 GO:0019902 phosphatase binding 13/844 190/18639 0.068421052631579 1.51101895734597 0.0912518166833467 0.384561227451247 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/844 24/18639 0.125 2.7605154028436 0.0925042348327805 0.386389370274977 GO:0050431 transforming growth factor beta binding 3/844 24/18639 0.125 2.7605154028436 0.0925042348327805 0.386389370274977 GO:0004875 complement receptor activity 2/844 12/18639 0.166666666666667 3.68068720379147 0.100102289824055 0.402113028059183 GO:0005095 GTPase inhibitor activity 2/844 12/18639 0.166666666666667 3.68068720379147 0.100102289824055 0.402113028059183 GO:0015132 prostaglandin transmembrane transporter activity 2/844 12/18639 0.166666666666667 3.68068720379147 0.100102289824055 0.402113028059183 GO:0016208 AMP binding 2/844 12/18639 0.166666666666667 3.68068720379147 0.100102289824055 0.402113028059183 GO:0034452 dynactin binding 2/844 12/18639 0.166666666666667 3.68068720379147 0.100102289824055 0.402113028059183 GO:0035259 nuclear glucocorticoid receptor binding 2/844 12/18639 0.166666666666667 3.68068720379147 0.100102289824055 0.402113028059183 GO:0070679 inositol 1,4,5 trisphosphate binding 2/844 12/18639 0.166666666666667 3.68068720379147 0.100102289824055 0.402113028059183 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/844 12/18639 0.166666666666667 3.68068720379147 0.100102289824055 0.402113028059183 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 2/844 12/18639 0.166666666666667 3.68068720379147 0.100102289824055 0.402113028059183 GO:0005537 D-mannose binding 3/844 25/18639 0.12 2.65009478672986 0.101745577018125 0.403562288676932 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/844 25/18639 0.12 2.65009478672986 0.101745577018125 0.403562288676932 GO:0019211 phosphatase activator activity 3/844 25/18639 0.12 2.65009478672986 0.101745577018125 0.403562288676932 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 4/844 40/18639 0.1 2.20841232227488 0.105782942097224 0.417820490961419 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 7/844 89/18639 0.0786516853932584 1.73695351190159 0.108458252107712 0.423797660050284 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 7/844 89/18639 0.0786516853932584 1.73695351190159 0.108458252107712 0.423797660050284 GO:0019212 phosphatase inhibitor activity 5/844 56/18639 0.0892857142857143 1.97179671631686 0.108658356140224 0.423797660050284 GO:0099106 ion channel regulator activity 11/844 160/18639 0.06875 1.51828347156398 0.110860158079169 0.423797660050284 GO:0008198 ferrous iron binding 3/844 26/18639 0.115384615384615 2.54816806416332 0.111336673403041 0.423797660050284 GO:0030247 polysaccharide binding 3/844 26/18639 0.115384615384615 2.54816806416332 0.111336673403041 0.423797660050284 GO:0030507 spectrin binding 3/844 26/18639 0.115384615384615 2.54816806416332 0.111336673403041 0.423797660050284 GO:0043548 phosphatidylinositol 3-kinase binding 3/844 26/18639 0.115384615384615 2.54816806416332 0.111336673403041 0.423797660050284 GO:0070006 metalloaminopeptidase activity 3/844 26/18639 0.115384615384615 2.54816806416332 0.111336673403041 0.423797660050284 GO:0042287 MHC protein binding 4/844 41/18639 0.0975609756097561 2.15454860709745 0.113257556622199 0.425281682964314 GO:0140793 histone H2AXY142 phosphatase activity 7/844 90/18639 0.0777777777777778 1.71765402843602 0.113297805174549 0.425281682964314 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 21/844 349/18639 0.0601719197707736 1.32884409076712 0.113810481379199 0.425281682964314 GO:0005172 vascular endothelial growth factor receptor binding 2/844 13/18639 0.153846153846154 3.39755741888443 0.11488011563125 0.425281682964314 GO:0008035 high-density lipoprotein particle binding 2/844 13/18639 0.153846153846154 3.39755741888443 0.11488011563125 0.425281682964314 GO:0035673 oligopeptide transmembrane transporter activity 2/844 13/18639 0.153846153846154 3.39755741888443 0.11488011563125 0.425281682964314 GO:0071714 icosanoid transmembrane transporter activity 2/844 13/18639 0.153846153846154 3.39755741888443 0.11488011563125 0.425281682964314 GO:0005496 steroid binding 8/844 108/18639 0.0740740740740741 1.63586097946288 0.11664191579999 0.430117064512463 GO:0019894 kinesin binding 4/844 42/18639 0.0952380952380952 2.10324983073798 0.120958020161168 0.442575081519933 GO:0051879 Hsp90 protein binding 4/844 42/18639 0.0952380952380952 2.10324983073798 0.120958020161168 0.442575081519933 GO:0016829 lyase activity 13/844 200/18639 0.065 1.43546800947867 0.122091753125896 0.444521981820823 GO:0042826 histone deacetylase binding 9/844 127/18639 0.0708661417322835 1.56501660633653 0.122431901772684 0.444521981820823 GO:0051020 GTPase binding 19/844 315/18639 0.0603174603174603 1.33205822613406 0.125434572049087 0.453679065189036 GO:0045309 protein phosphorylated amino acid binding 5/844 59/18639 0.0847457627118644 1.87153586633465 0.127994455235062 0.456789724462215 GO:0008200 ion channel inhibitor activity 4/844 43/18639 0.0930232558139535 2.05433704397663 0.12887625277462 0.456789724462215 GO:0019992 diacylglycerol binding 2/844 14/18639 0.142857142857143 3.15487474610697 0.130165715974932 0.456789724462215 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/844 14/18639 0.142857142857143 3.15487474610697 0.130165715974932 0.456789724462215 GO:0032036 myosin heavy chain binding 2/844 14/18639 0.142857142857143 3.15487474610697 0.130165715974932 0.456789724462215 GO:0034236 protein kinase A catalytic subunit binding 2/844 14/18639 0.142857142857143 3.15487474610697 0.130165715974932 0.456789724462215 GO:0042043 neurexin family protein binding 2/844 14/18639 0.142857142857143 3.15487474610697 0.130165715974932 0.456789724462215 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2/844 14/18639 0.142857142857143 3.15487474610697 0.130165715974932 0.456789724462215 GO:0051019 mitogen-activated protein kinase binding 3/844 28/18639 0.107142857142857 2.36615605958023 0.131487961467544 0.458024485702442 GO:0097718 disordered domain specific binding 3/844 28/18639 0.107142857142857 2.36615605958023 0.131487961467544 0.458024485702442 GO:1901981 phosphatidylinositol phosphate binding 12/844 185/18639 0.0648648648648649 1.43248366850263 0.134922942533803 0.468261977029081 GO:0005200 structural constituent of cytoskeleton 8/844 112/18639 0.0714285714285714 1.57743737305349 0.135463488291208 0.468415871600368 GO:0016248 channel inhibitor activity 4/844 44/18639 0.0909090909090909 2.00764756570444 0.137003852723845 0.470296861713852 GO:0030547 signaling receptor inhibitor activity 4/844 44/18639 0.0909090909090909 2.00764756570444 0.137003852723845 0.470296861713852 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 5/844 61/18639 0.0819672131147541 1.81017403465154 0.141694877127473 0.481515728480063 GO:0043236 laminin binding 3/844 29/18639 0.103448275862069 2.28456447131884 0.142007465621651 0.481515728480063 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/844 29/18639 0.103448275862069 2.28456447131884 0.142007465621651 0.481515728480063 GO:0141110 transporter inhibitor activity 4/844 45/18639 0.0888888888888889 1.96303317535545 0.145332138759736 0.481515728480063 GO:0004559 alpha-mannosidase activity 2/844 15/18639 0.133333333333333 2.94454976303318 0.145882943162392 0.481515728480063 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/844 15/18639 0.133333333333333 2.94454976303318 0.145882943162392 0.481515728480063 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/844 15/18639 0.133333333333333 2.94454976303318 0.145882943162392 0.481515728480063 GO:0005523 tropomyosin binding 2/844 15/18639 0.133333333333333 2.94454976303318 0.145882943162392 0.481515728480063 GO:0015116 sulfate transmembrane transporter activity 2/844 15/18639 0.133333333333333 2.94454976303318 0.145882943162392 0.481515728480063 GO:0141050 histone H3K deacetylase activity 2/844 15/18639 0.133333333333333 2.94454976303318 0.145882943162392 0.481515728480063 GO:0141051 histone H4K deacetylase activity 2/844 15/18639 0.133333333333333 2.94454976303318 0.145882943162392 0.481515728480063 GO:0005516 calmodulin binding 13/844 207/18639 0.0628019323671498 1.38692561302287 0.146826292261406 0.482801957863873 GO:0033293 monocarboxylic acid binding 6/844 79/18639 0.0759493670886076 1.67727518147459 0.147773134374734 0.482801957863873 GO:0035091 phosphatidylinositol binding 17/844 284/18639 0.0598591549295775 1.3219369534744 0.147806955320614 0.482801957863873 GO:0001965 G-protein alpha-subunit binding 3/844 30/18639 0.1 2.20841232227488 0.152795594286279 0.495666807581605 GO:0001968 fibronectin binding 3/844 30/18639 0.1 2.20841232227488 0.152795594286279 0.495666807581605 GO:0048306 calcium-dependent protein binding 6/844 80/18639 0.075 1.65630924170616 0.154070980534561 0.498092485015841 GO:0004725 protein tyrosine phosphatase activity 7/844 98/18639 0.0714285714285714 1.57743737305349 0.155903307010798 0.500899621935828 GO:0005507 copper ion binding 5/844 63/18639 0.0793650793650794 1.75270819228165 0.156000517848658 0.500899621935828 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/844 16/18639 0.125 2.7605154028436 0.161961490074637 0.514786688991439 GO:0005159 insulin-like growth factor receptor binding 2/844 16/18639 0.125 2.7605154028436 0.161961490074637 0.514786688991439 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/844 16/18639 0.125 2.7605154028436 0.161961490074637 0.514786688991439 GO:0005184 neuropeptide hormone activity 3/844 31/18639 0.0967741935483871 2.13717321510472 0.163831928670165 0.515524468882121 GO:0017147 Wnt-protein binding 3/844 31/18639 0.0967741935483871 2.13717321510472 0.163831928670165 0.515524468882121 GO:0070273 phosphatidylinositol-4-phosphate binding 3/844 31/18639 0.0967741935483871 2.13717321510472 0.163831928670165 0.515524468882121 GO:0005216 monoatomic ion channel activity 25/844 448/18639 0.0558035714285714 1.23237294769804 0.165360021187378 0.518604186049452 GO:0140693 molecular condensate scaffold activity 4/844 48/18639 0.0833333333333333 1.84034360189573 0.171430949314039 0.527444546601559 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/844 32/18639 0.09375 2.0703865521327 0.175096196065268 0.527444546601559 GO:0160041 neuropeptide activity 3/844 32/18639 0.09375 2.0703865521327 0.175096196065268 0.527444546601559 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/844 17/18639 0.117647058823529 2.5981321438528 0.178336518381376 0.527444546601559 GO:0008429 phosphatidylethanolamine binding 2/844 17/18639 0.117647058823529 2.5981321438528 0.178336518381376 0.527444546601559 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/844 17/18639 0.117647058823529 2.5981321438528 0.178336518381376 0.527444546601559 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/844 17/18639 0.117647058823529 2.5981321438528 0.178336518381376 0.527444546601559 GO:0016805 dipeptidase activity 2/844 17/18639 0.117647058823529 2.5981321438528 0.178336518381376 0.527444546601559 GO:0046965 nuclear retinoid X receptor binding 2/844 17/18639 0.117647058823529 2.5981321438528 0.178336518381376 0.527444546601559 GO:0070492 oligosaccharide binding 2/844 17/18639 0.117647058823529 2.5981321438528 0.178336518381376 0.527444546601559 GO:0008235 metalloexopeptidase activity 5/844 66/18639 0.0757575757575758 1.67303963808703 0.178506159650075 0.527444546601559 GO:0005004 GPI-linked ephrin receptor activity 4/844 49/18639 0.0816326530612245 1.80278556920398 0.180470962449474 0.527444546601559 GO:0005008 hepatocyte growth factor receptor activity 4/844 49/18639 0.0816326530612245 1.80278556920398 0.180470962449474 0.527444546601559 GO:0005009 insulin receptor activity 4/844 49/18639 0.0816326530612245 1.80278556920398 0.180470962449474 0.527444546601559 GO:0005011 macrophage colony-stimulating factor receptor activity 4/844 49/18639 0.0816326530612245 1.80278556920398 0.180470962449474 0.527444546601559 GO:0005018 platelet-derived growth factor alpha-receptor activity 4/844 49/18639 0.0816326530612245 1.80278556920398 0.180470962449474 0.527444546601559 GO:0005020 stem cell factor receptor activity 4/844 49/18639 0.0816326530612245 1.80278556920398 0.180470962449474 0.527444546601559 GO:0008288 boss receptor activity 4/844 49/18639 0.0816326530612245 1.80278556920398 0.180470962449474 0.527444546601559 GO:0035254 glutamate receptor binding 4/844 49/18639 0.0816326530612245 1.80278556920398 0.180470962449474 0.527444546601559 GO:0036332 placental growth factor receptor activity 4/844 49/18639 0.0816326530612245 1.80278556920398 0.180470962449474 0.527444546601559 GO:0038062 protein tyrosine kinase collagen receptor activity 4/844 49/18639 0.0816326530612245 1.80278556920398 0.180470962449474 0.527444546601559 GO:0060175 brain-derived neurotrophic factor receptor activity 4/844 49/18639 0.0816326530612245 1.80278556920398 0.180470962449474 0.527444546601559 GO:0019956 chemokine binding 3/844 33/18639 0.0909090909090909 2.00764756570444 0.186568350246176 0.543581859976513 GO:0005543 phospholipid binding 27/844 497/18639 0.0543259557344064 1.19974110063223 0.188931564052454 0.544207172601777 GO:0005006 epidermal growth factor receptor activity 4/844 50/18639 0.08 1.76672985781991 0.189665423502102 0.544207172601777 GO:0005007 fibroblast growth factor receptor activity 4/844 50/18639 0.08 1.76672985781991 0.189665423502102 0.544207172601777 GO:0005017 platelet-derived growth factor receptor activity 4/844 50/18639 0.08 1.76672985781991 0.189665423502102 0.544207172601777 GO:0005019 platelet-derived growth factor beta-receptor activity 4/844 50/18639 0.08 1.76672985781991 0.189665423502102 0.544207172601777 GO:0032934 sterol binding 5/844 68/18639 0.0735294117647059 1.623832589908 0.194145946754659 0.55264625560987 GO:0003746 translation elongation factor activity 2/844 18/18639 0.111111111111111 2.45379146919431 0.194948308387804 0.55264625560987 GO:0015172 acidic amino acid transmembrane transporter activity 2/844 18/18639 0.111111111111111 2.45379146919431 0.194948308387804 0.55264625560987 GO:1990381 ubiquitin-specific protease binding 2/844 18/18639 0.111111111111111 2.45379146919431 0.194948308387804 0.55264625560987 GO:0005010 insulin-like growth factor receptor activity 4/844 51/18639 0.0784313725490196 1.73208809590187 0.199004765644682 0.559108627287439 GO:0005030 neurotrophin receptor activity 4/844 51/18639 0.0784313725490196 1.73208809590187 0.199004765644682 0.559108627287439 GO:0030544 Hsp70 protein binding 4/844 51/18639 0.0784313725490196 1.73208809590187 0.199004765644682 0.559108627287439 GO:0008013 beta-catenin binding 7/844 106/18639 0.0660377358490566 1.4583854958419 0.204715154125514 0.573445416897583 GO:0005261 monoatomic cation channel activity 19/844 341/18639 0.0557184750733138 1.23049366930272 0.206543690637031 0.576855751364963 GO:0030159 signaling receptor complex adaptor activity 4/844 52/18639 0.0769230769230769 1.69877870944222 0.208479389575075 0.579375018197365 GO:0016229 steroid dehydrogenase activity 3/844 35/18639 0.0857142857142857 1.89292484766418 0.210057680477404 0.579375018197365 GO:0008028 monocarboxylic acid transmembrane transporter activity 5/844 70/18639 0.0714285714285714 1.57743737305349 0.210242643059085 0.579375018197365 GO:0019888 protein phosphatase regulator activity 7/844 107/18639 0.0654205607476635 1.44475572485273 0.211193350520665 0.579375018197365 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/844 19/18639 0.105263157894737 2.32464454976303 0.211741929320011 0.579375018197365 GO:0008381 mechanosensitive monoatomic ion channel activity 2/844 19/18639 0.105263157894737 2.32464454976303 0.211741929320011 0.579375018197365 GO:0030506 ankyrin binding 2/844 19/18639 0.105263157894737 2.32464454976303 0.211741929320011 0.579375018197365 GO:0042578 phosphoric ester hydrolase activity 20/844 363/18639 0.0550964187327824 1.21675610042693 0.213036221081091 0.581231770810839 GO:0004864 protein phosphatase inhibitor activity 4/844 53/18639 0.0754716981132075 1.66672628096217 0.218079691570676 0.586516321489226 GO:0005003 ephrin receptor activity 4/844 53/18639 0.0754716981132075 1.66672628096217 0.218079691570676 0.586516321489226 GO:0005005 transmembrane-ephrin receptor activity 4/844 53/18639 0.0754716981132075 1.66672628096217 0.218079691570676 0.586516321489226 GO:0016860 intramolecular oxidoreductase activity 4/844 53/18639 0.0754716981132075 1.66672628096217 0.218079691570676 0.586516321489226 GO:0038064 collagen receptor activity 4/844 53/18639 0.0754716981132075 1.66672628096217 0.218079691570676 0.586516321489226 GO:0015085 calcium ion transmembrane transporter activity 9/844 147/18639 0.0612244897959184 1.35208917690299 0.222756916244267 0.597393548109626 GO:0015485 cholesterol binding 4/844 54/18639 0.0740740740740741 1.63586097946288 0.227796089761076 0.609177078567863 GO:0016004 phospholipase activator activity 2/844 20/18639 0.1 2.20841232227488 0.228666928919376 0.609778477118336 GO:0035591 signaling adaptor activity 8/844 129/18639 0.062015503875969 1.36955802931776 0.230252988854935 0.612278370363546 GO:0046943 carboxylic acid transmembrane transporter activity 11/844 188/18639 0.0585106382978723 1.2921561460119 0.233320206059408 0.615848691233885 GO:0030551 cyclic nucleotide binding 3/844 37/18639 0.0810810810810811 1.79060458562828 0.234146538287791 0.615848691233885 GO:0042805 actinin binding 3/844 37/18639 0.0810810810810811 1.79060458562828 0.234146538287791 0.615848691233885 GO:0008509 monoatomic anion transmembrane transporter activity 9/844 149/18639 0.0604026845637584 1.33394032889087 0.234205169653564 0.615848691233885 GO:0043539 protein serine/threonine kinase activator activity 5/844 73/18639 0.0684931506849315 1.51261117964033 0.23514393571604 0.616599653655394 GO:0005342 organic acid transmembrane transporter activity 11/844 189/18639 0.0582010582010582 1.28531934100654 0.23845112752693 0.623539790541334 GO:0048029 monosaccharide binding 5/844 74/18639 0.0675675675675676 1.49217048802357 0.243622740784492 0.633714169677848 GO:0010314 phosphatidylinositol-5-phosphate binding 2/844 21/18639 0.0952380952380952 2.10324983073798 0.245677041276471 0.633714169677848 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/844 21/18639 0.0952380952380952 2.10324983073798 0.245677041276471 0.633714169677848 GO:0000146 microfilament motor activity 3/844 38/18639 0.0789473684210526 1.74348341232227 0.246369809609926 0.633714169677848 GO:0005501 retinoid binding 3/844 38/18639 0.0789473684210526 1.74348341232227 0.246369809609926 0.633714169677848 GO:0019840 isoprenoid binding 3/844 38/18639 0.0789473684210526 1.74348341232227 0.246369809609926 0.633714169677848 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/844 39/18639 0.0769230769230769 1.69877870944222 0.258688802838908 0.663147157289273 GO:0004867 serine-type endopeptidase inhibitor activity 6/844 95/18639 0.0631578947368421 1.39478672985782 0.260549540896447 0.663147157289273 GO:0051087 protein-folding chaperone binding 8/844 134/18639 0.0597014925373134 1.31845511777605 0.261826306502363 0.663147157289273 GO:0004407 histone deacetylase activity 2/844 22/18639 0.0909090909090909 2.00764756570444 0.262729911892149 0.663147157289273 GO:0031683 G-protein beta/gamma-subunit complex binding 2/844 22/18639 0.0909090909090909 2.00764756570444 0.262729911892149 0.663147157289273 GO:0033558 protein lysine deacetylase activity 2/844 22/18639 0.0909090909090909 2.00764756570444 0.262729911892149 0.663147157289273 GO:0033691 sialic acid binding 2/844 22/18639 0.0909090909090909 2.00764756570444 0.262729911892149 0.663147157289273 GO:0004177 aminopeptidase activity 3/844 40/18639 0.075 1.65630924170616 0.271086575331477 0.680600338066261 GO:0071855 neuropeptide receptor binding 3/844 40/18639 0.075 1.65630924170616 0.271086575331477 0.680600338066261 GO:0004879 nuclear receptor activity 4/844 59/18639 0.0677966101694915 1.49722869306772 0.277788635028415 0.69373669700218 GO:0070888 E-box binding 4/844 59/18639 0.0677966101694915 1.49722869306772 0.277788635028415 0.69373669700218 GO:0005283 amino acid:sodium symporter activity 2/844 23/18639 0.0869565217391304 1.92035854110859 0.279786839007562 0.69688331404522 GO:0017080 sodium channel regulator activity 3/844 41/18639 0.0731707317073171 1.61591145532308 0.283546761019052 0.704389848426275 GO:0098531 ligand-modulated transcription factor activity 4/844 60/18639 0.0666666666666667 1.47227488151659 0.288004492131037 0.713585933259053 GO:0030295 protein kinase activator activity 8/844 139/18639 0.0575539568345324 1.27102867469058 0.294594615637719 0.720285420564506 GO:0035198 miRNA binding 3/844 42/18639 0.0714285714285714 1.57743737305349 0.296053587238889 0.720285420564506 GO:0048487 beta-tubulin binding 3/844 42/18639 0.0714285714285714 1.57743737305349 0.296053587238889 0.720285420564506 GO:0001091 RNA polymerase II general transcription initiation factor binding 2/844 24/18639 0.0833333333333333 1.84034360189573 0.296812530296179 0.720285420564506 GO:0030552 cAMP binding 2/844 24/18639 0.0833333333333333 1.84034360189573 0.296812530296179 0.720285420564506 GO:0035035 histone acetyltransferase binding 2/844 24/18639 0.0833333333333333 1.84034360189573 0.296812530296179 0.720285420564506 GO:0060229 lipase activator activity 2/844 24/18639 0.0833333333333333 1.84034360189573 0.296812530296179 0.720285420564506 GO:0070840 dynein complex binding 2/844 24/18639 0.0833333333333333 1.84034360189573 0.296812530296179 0.720285420564506 GO:0031267 small GTPase binding 15/844 283/18639 0.0530035335689046 1.17053656657679 0.302310154175275 0.73174560395246 GO:0015179 L-amino acid transmembrane transporter activity 4/844 62/18639 0.0645161290322581 1.42478214340315 0.308581996659713 0.745016380682273 GO:0003707 nuclear steroid receptor activity 2/844 25/18639 0.08 1.76672985781991 0.313774874059488 0.749882230663688 GO:0015662 P-type ion transporter activity 2/844 25/18639 0.08 1.76672985781991 0.313774874059488 0.749882230663688 GO:0042974 nuclear retinoic acid receptor binding 2/844 25/18639 0.08 1.76672985781991 0.313774874059488 0.749882230663688 GO:0140358 P-type transmembrane transporter activity 2/844 25/18639 0.08 1.76672985781991 0.313774874059488 0.749882230663688 GO:0015171 amino acid transmembrane transporter activity 6/844 102/18639 0.0588235294117647 1.2990660719264 0.315684796931638 0.752541536119863 GO:1901682 sulfur compound transmembrane transporter activity 4/844 63/18639 0.0634920634920635 1.40216655382532 0.31892650369775 0.758354205266186 GO:0008237 metallopeptidase activity 10/844 184/18639 0.0543478260869565 1.20022408819287 0.322799782639299 0.763739925213558 GO:0008135 translation factor activity, RNA binding 5/844 83/18639 0.0602409638554217 1.33036886884029 0.32280956584768 0.763739925213558 GO:0005253 monoatomic anion channel activity 6/844 103/18639 0.058252427184466 1.28645377996595 0.323721564866845 0.763982893085755 GO:0015081 sodium ion transmembrane transporter activity 9/844 164/18639 0.0548780487804878 1.21193359149231 0.325670892908482 0.764818809664575 GO:0019903 protein phosphatase binding 8/844 144/18639 0.0555555555555556 1.22689573459716 0.328265955829996 0.764818809664575 GO:0004435 phosphatidylinositol phospholipase C activity 2/844 26/18639 0.0769230769230769 1.69877870944222 0.330644724114192 0.764818809664575 GO:0005160 transforming growth factor beta receptor binding 2/844 26/18639 0.0769230769230769 1.69877870944222 0.330644724114192 0.764818809664575 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/844 26/18639 0.0769230769230769 1.69877870944222 0.330644724114192 0.764818809664575 GO:0034237 protein kinase A regulatory subunit binding 2/844 26/18639 0.0769230769230769 1.69877870944222 0.330644724114192 0.764818809664575 GO:0050681 nuclear androgen receptor binding 2/844 26/18639 0.0769230769230769 1.69877870944222 0.330644724114192 0.764818809664575 GO:0070412 R-SMAD binding 2/844 26/18639 0.0769230769230769 1.69877870944222 0.330644724114192 0.764818809664575 GO:0180051 translation factor activity 5/844 84/18639 0.0595238095238095 1.31453114421124 0.331823158496025 0.764818809664575 GO:0046915 transition metal ion transmembrane transporter activity 3/844 45/18639 0.0666666666666667 1.47227488151659 0.333705321553878 0.764818809664575 GO:0140303 intramembrane lipid transporter activity 3/844 45/18639 0.0666666666666667 1.47227488151659 0.333705321553878 0.764818809664575 GO:0008514 organic anion transmembrane transporter activity 14/844 269/18639 0.0520446096654275 1.14935957293116 0.334910147265089 0.764818809664575 GO:0120013 lipid transfer activity 4/844 65/18639 0.0615384615384615 1.35902296755377 0.33968562609455 0.764818809664575 GO:0001671 ATPase activator activity 2/844 27/18639 0.0740740740740741 1.63586097946288 0.347395697602347 0.764818809664575 GO:0005104 fibroblast growth factor receptor binding 2/844 27/18639 0.0740740740740741 1.63586097946288 0.347395697602347 0.764818809664575 GO:0008320 protein transmembrane transporter activity 2/844 27/18639 0.0740740740740741 1.63586097946288 0.347395697602347 0.764818809664575 GO:0035255 ionotropic glutamate receptor binding 2/844 27/18639 0.0740740740740741 1.63586097946288 0.347395697602347 0.764818809664575 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/844 27/18639 0.0740740740740741 1.63586097946288 0.347395697602347 0.764818809664575 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 5/844 86/18639 0.0581395348837209 1.2839606524854 0.349913255357971 0.764818809664575 GO:0043177 organic acid binding 10/844 189/18639 0.0529100529100529 1.16847212818777 0.352889070939157 0.764818809664575 GO:0019209 kinase activator activity 8/844 148/18639 0.0540540540540541 1.19373639041885 0.355655507161674 0.764818809664575 GO:0016500 protein-hormone receptor activity 4/844 67/18639 0.0597014925373134 1.31845511777605 0.360485456077812 0.764818809664575 GO:0019789 SUMO transferase activity 2/844 28/18639 0.0714285714285714 1.57743737305349 0.364003984997332 0.764818809664575 GO:0046625 sphingolipid binding 2/844 28/18639 0.0714285714285714 1.57743737305349 0.364003984997332 0.764818809664575 GO:0004197 cysteine-type endopeptidase activity 5/844 88/18639 0.0568181818181818 1.25477972856527 0.36805244360984 0.764818809664575 GO:0001094 TFIID-class transcription factor complex binding 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0003796 lysozyme activity 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0005345 purine nucleobase transmembrane transporter activity 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0005528 FK506 binding 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0008140 cAMP response element binding protein binding 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0008519 ammonium channel activity 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0015279 store-operated calcium channel activity 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0030957 Tat protein binding 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0032356 oxidized DNA binding 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0035256 G protein-coupled glutamate receptor binding 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0043121 neurotrophin binding 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0043208 glycosphingolipid binding 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0043295 glutathione binding 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0047429 nucleoside triphosphate diphosphatase activity 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0051880 G-quadruplex DNA binding 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0070097 delta-catenin binding 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0070513 death domain binding 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0071723 lipopeptide binding 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0140135 mechanosensitive monoatomic cation channel activity 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:1905394 retromer complex binding 1/844 10/18639 0.1 2.20841232227488 0.370922586126663 0.764818809664575 GO:0032266 phosphatidylinositol-3-phosphate binding 3/844 48/18639 0.0625 1.3802577014218 0.371267910313884 0.764818809664575 GO:0001216 DNA-binding transcription activator activity 24/844 491/18639 0.0488798370672098 1.07946834490015 0.379163736784027 0.764818809664575 GO:0001217 DNA-binding transcription repressor activity 14/844 278/18639 0.0503597122302158 1.11215009035426 0.380324163786212 0.764818809664575 GO:0004181 metallocarboxypeptidase activity 2/844 29/18639 0.0689655172413793 1.52304298087923 0.380448171617752 0.764818809664575 GO:0004629 phospholipase C activity 2/844 29/18639 0.0689655172413793 1.52304298087923 0.380448171617752 0.764818809664575 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 2/844 29/18639 0.0689655172413793 1.52304298087923 0.380448171617752 0.764818809664575 GO:0005416 amino acid:monoatomic cation symporter activity 2/844 29/18639 0.0689655172413793 1.52304298087923 0.380448171617752 0.764818809664575 GO:0051861 glycolipid binding 2/844 29/18639 0.0689655172413793 1.52304298087923 0.380448171617752 0.764818809664575 GO:0097472 cyclin-dependent protein kinase activity 2/844 29/18639 0.0689655172413793 1.52304298087923 0.380448171617752 0.764818809664575 GO:0005262 calcium channel activity 7/844 131/18639 0.0534351145038168 1.18006765312398 0.382402348425736 0.764818809664575 GO:0015631 tubulin binding 19/844 385/18639 0.0493506493506494 1.08986582138241 0.383016055253004 0.764818809664575 GO:0016763 pentosyltransferase activity 3/844 49/18639 0.0612244897959184 1.35208917690299 0.383711189522433 0.764818809664575 GO:0060590 ATPase regulator activity 3/844 49/18639 0.0612244897959184 1.35208917690299 0.383711189522433 0.764818809664575 GO:1902936 phosphatidylinositol bisphosphate binding 6/844 111/18639 0.0540540540540541 1.19373639041885 0.388708632869431 0.764818809664575 GO:0000099 sulfur amino acid transmembrane transporter activity 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0003953 NAD+ nucleosidase activity 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0004016 adenylate cyclase activity 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0008172 S-methyltransferase activity 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0008199 ferric iron binding 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0008503 benzodiazepine receptor activity 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0008526 phosphatidylinositol transfer activity 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0010854 adenylate cyclase regulator activity 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0015173 aromatic amino acid transmembrane transporter activity 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0015205 nucleobase transmembrane transporter activity 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0015217 ADP transmembrane transporter activity 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0019215 intermediate filament binding 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0035252 UDP-xylosyltransferase activity 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0042285 xylosyltransferase activity 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0047676 arachidonate-CoA ligase activity 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0050998 nitric-oxide synthase binding 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0070697 activin receptor binding 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0070990 snRNP binding 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:1900750 oligopeptide binding 1/844 11/18639 0.0909090909090909 2.00764756570444 0.399423382589656 0.764818809664575 GO:0140299 molecular sensor activity 4/844 71/18639 0.0563380281690141 1.2441759562112 0.40197008546445 0.768137167365265 GO:0046982 protein heterodimerization activity 18/844 369/18639 0.0487804878048781 1.07727430354872 0.406957886629905 0.775742655083673 GO:0003743 translation initiation factor activity 3/844 51/18639 0.0588235294117647 1.2990660719264 0.408415359720959 0.775742655083673 GO:0005272 sodium channel activity 3/844 51/18639 0.0588235294117647 1.2990660719264 0.408415359720959 0.775742655083673 GO:0005164 tumor necrosis factor receptor binding 2/844 31/18639 0.0645161290322581 1.42478214340315 0.41276956250398 0.782438688762564 GO:0140789 histone phosphatase activity 7/844 136/18639 0.0514705882352941 1.1366828129356 0.419735663573414 0.785073811161035 GO:0001221 transcription coregulator binding 6/844 115/18639 0.0521739130434783 1.15221512466516 0.421281872240877 0.785073811161035 GO:0005247 voltage-gated chloride channel activity 1/844 12/18639 0.0833333333333333 1.84034360189573 0.426634391022893 0.785073811161035 GO:0005527 macrolide binding 1/844 12/18639 0.0833333333333333 1.84034360189573 0.426634391022893 0.785073811161035 GO:0008179 adenylate cyclase binding 1/844 12/18639 0.0833333333333333 1.84034360189573 0.426634391022893 0.785073811161035 GO:0010853 cyclase activator activity 1/844 12/18639 0.0833333333333333 1.84034360189573 0.426634391022893 0.785073811161035 GO:0015368 calcium:monoatomic cation antiporter activity 1/844 12/18639 0.0833333333333333 1.84034360189573 0.426634391022893 0.785073811161035 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/844 12/18639 0.0833333333333333 1.84034360189573 0.426634391022893 0.785073811161035 GO:0045295 gamma-catenin binding 1/844 12/18639 0.0833333333333333 1.84034360189573 0.426634391022893 0.785073811161035 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/844 12/18639 0.0833333333333333 1.84034360189573 0.426634391022893 0.785073811161035 GO:0070008 serine-type exopeptidase activity 1/844 12/18639 0.0833333333333333 1.84034360189573 0.426634391022893 0.785073811161035 GO:0070410 co-SMAD binding 1/844 12/18639 0.0833333333333333 1.84034360189573 0.426634391022893 0.785073811161035 GO:0097677 STAT family protein binding 1/844 12/18639 0.0833333333333333 1.84034360189573 0.426634391022893 0.785073811161035 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/844 12/18639 0.0833333333333333 1.84034360189573 0.426634391022893 0.785073811161035 GO:1990459 transferrin receptor binding 1/844 12/18639 0.0833333333333333 1.84034360189573 0.426634391022893 0.785073811161035 GO:0022884 macromolecule transmembrane transporter activity 2/844 32/18639 0.0625 1.3802577014218 0.428614453599893 0.787182965366341 GO:0051018 protein kinase A binding 3/844 53/18639 0.0566037735849057 1.25004471072163 0.432810936239851 0.791809154671355 GO:0140296 general transcription initiation factor binding 3/844 53/18639 0.0566037735849057 1.25004471072163 0.432810936239851 0.791809154671355 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 23/844 484/18639 0.0475206611570248 1.04945213661823 0.436189890995441 0.79644730580212 GO:0004896 cytokine receptor activity 5/844 96/18639 0.0520833333333333 1.15021475118483 0.440320979817675 0.802438233490126 GO:0003725 double-stranded RNA binding 4/844 75/18639 0.0533333333333333 1.17781990521327 0.442943908504117 0.80393010417585 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2/844 33/18639 0.0606060606060606 1.33843171046963 0.444230331235618 0.80393010417585 GO:0140416 transcription regulator inhibitor activity 2/844 33/18639 0.0606060606060606 1.33843171046963 0.444230331235618 0.80393010417585 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/844 13/18639 0.0769230769230769 1.69877870944222 0.452613913972197 0.80393010417585 GO:0005542 folic acid binding 1/844 13/18639 0.0769230769230769 1.69877870944222 0.452613913972197 0.80393010417585 GO:0019855 calcium channel inhibitor activity 1/844 13/18639 0.0769230769230769 1.69877870944222 0.452613913972197 0.80393010417585 GO:0031432 titin binding 1/844 13/18639 0.0769230769230769 1.69877870944222 0.452613913972197 0.80393010417585 GO:0031994 insulin-like growth factor I binding 1/844 13/18639 0.0769230769230769 1.69877870944222 0.452613913972197 0.80393010417585 GO:0032396 inhibitory MHC class I receptor activity 1/844 13/18639 0.0769230769230769 1.69877870944222 0.452613913972197 0.80393010417585 GO:0039706 co-receptor binding 1/844 13/18639 0.0769230769230769 1.69877870944222 0.452613913972197 0.80393010417585 GO:0071837 HMG box domain binding 1/844 13/18639 0.0769230769230769 1.69877870944222 0.452613913972197 0.80393010417585 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/844 13/18639 0.0769230769230769 1.69877870944222 0.452613913972197 0.80393010417585 GO:0140333 glycerophospholipid flippase activity 1/844 13/18639 0.0769230769230769 1.69877870944222 0.452613913972197 0.80393010417585 GO:0017022 myosin binding 4/844 76/18639 0.0526315789473684 1.16232227488152 0.453062304471983 0.80393010417585 GO:0098632 cell-cell adhesion mediator activity 3/844 55/18639 0.0545454545454545 1.20458853942266 0.456827455270894 0.809090277252765 GO:0030332 cyclin binding 2/844 34/18639 0.0588235294117647 1.2990660719264 0.459605436814115 0.812040062533086 GO:0015108 chloride transmembrane transporter activity 6/844 121/18639 0.0495867768595041 1.09508049038424 0.46963398707712 0.812040062533086 GO:0015103 inorganic anion transmembrane transporter activity 8/844 165/18639 0.0484848484848485 1.0707453683757 0.473053338324504 0.812040062533086 GO:0031406 carboxylic acid binding 9/844 187/18639 0.0481283422459893 1.06287224066706 0.474224598482879 0.812040062533086 GO:0005154 epidermal growth factor receptor binding 2/844 35/18639 0.0571428571428571 1.26194989844279 0.474729543258764 0.812040062533086 GO:0005343 organic acid:sodium symporter activity 2/844 35/18639 0.0571428571428571 1.26194989844279 0.474729543258764 0.812040062533086 GO:0004065 arylsulfatase activity 1/844 14/18639 0.0714285714285714 1.57743737305349 0.477417621510448 0.812040062533086 GO:0005313 L-glutamate transmembrane transporter activity 1/844 14/18639 0.0714285714285714 1.57743737305349 0.477417621510448 0.812040062533086 GO:0005347 ATP transmembrane transporter activity 1/844 14/18639 0.0714285714285714 1.57743737305349 0.477417621510448 0.812040062533086 GO:0008191 metalloendopeptidase inhibitor activity 1/844 14/18639 0.0714285714285714 1.57743737305349 0.477417621510448 0.812040062533086 GO:0008195 phosphatidate phosphatase activity 1/844 14/18639 0.0714285714285714 1.57743737305349 0.477417621510448 0.812040062533086 GO:0008331 high voltage-gated calcium channel activity 1/844 14/18639 0.0714285714285714 1.57743737305349 0.477417621510448 0.812040062533086 GO:0015386 potassium:proton antiporter activity 1/844 14/18639 0.0714285714285714 1.57743737305349 0.477417621510448 0.812040062533086 GO:0015926 glucosidase activity 1/844 14/18639 0.0714285714285714 1.57743737305349 0.477417621510448 0.812040062533086 GO:0016530 metallochaperone activity 1/844 14/18639 0.0714285714285714 1.57743737305349 0.477417621510448 0.812040062533086 GO:0031404 chloride ion binding 1/844 14/18639 0.0714285714285714 1.57743737305349 0.477417621510448 0.812040062533086 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/844 14/18639 0.0714285714285714 1.57743737305349 0.477417621510448 0.812040062533086 GO:0044548 S100 protein binding 1/844 14/18639 0.0714285714285714 1.57743737305349 0.477417621510448 0.812040062533086 GO:0046030 inositol trisphosphate phosphatase activity 1/844 14/18639 0.0714285714285714 1.57743737305349 0.477417621510448 0.812040062533086 GO:0061665 SUMO ligase activity 1/844 14/18639 0.0714285714285714 1.57743737305349 0.477417621510448 0.812040062533086 GO:0061783 peptidoglycan muralytic activity 1/844 14/18639 0.0714285714285714 1.57743737305349 0.477417621510448 0.812040062533086 GO:0071933 Arp2/3 complex binding 1/844 14/18639 0.0714285714285714 1.57743737305349 0.477417621510448 0.812040062533086 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/844 36/18639 0.0555555555555556 1.22689573459716 0.489593840711313 0.828273450952472 GO:0044390 ubiquitin-like protein conjugating enzyme binding 2/844 36/18639 0.0555555555555556 1.22689573459716 0.489593840711313 0.828273450952472 GO:0045505 dynein intermediate chain binding 2/844 36/18639 0.0555555555555556 1.22689573459716 0.489593840711313 0.828273450952472 GO:0061980 regulatory RNA binding 3/844 58/18639 0.0517241379310345 1.14228223565942 0.492008893359625 0.828436330027851 GO:0004089 carbonate dehydratase activity 1/844 15/18639 0.0666666666666667 1.47227488151659 0.50109866996388 0.828436330027851 GO:0004467 long-chain fatty acid-CoA ligase activity 1/844 15/18639 0.0666666666666667 1.47227488151659 0.50109866996388 0.828436330027851 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/844 15/18639 0.0666666666666667 1.47227488151659 0.50109866996388 0.828436330027851 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/844 15/18639 0.0666666666666667 1.47227488151659 0.50109866996388 0.828436330027851 GO:0015929 hexosaminidase activity 1/844 15/18639 0.0666666666666667 1.47227488151659 0.50109866996388 0.828436330027851 GO:0030553 cGMP binding 1/844 15/18639 0.0666666666666667 1.47227488151659 0.50109866996388 0.828436330027851 GO:0031005 filamin binding 1/844 15/18639 0.0666666666666667 1.47227488151659 0.50109866996388 0.828436330027851 GO:0047372 monoacylglycerol lipase activity 1/844 15/18639 0.0666666666666667 1.47227488151659 0.50109866996388 0.828436330027851 GO:0050700 CARD domain binding 1/844 15/18639 0.0666666666666667 1.47227488151659 0.50109866996388 0.828436330027851 GO:0050780 dopamine receptor binding 1/844 15/18639 0.0666666666666667 1.47227488151659 0.50109866996388 0.828436330027851 GO:0120283 protein serine/threonine kinase binding 1/844 15/18639 0.0666666666666667 1.47227488151659 0.50109866996388 0.828436330027851 GO:0140776 protein-containing complex destabilizing activity 1/844 15/18639 0.0666666666666667 1.47227488151659 0.50109866996388 0.828436330027851 GO:0019213 deacetylase activity 2/844 37/18639 0.0540540540540541 1.19373639041885 0.504190829421228 0.830638992973193 GO:0022829 wide pore channel activity 2/844 37/18639 0.0540540540540541 1.19373639041885 0.504190829421228 0.830638992973193 GO:0042887 amide transmembrane transporter activity 2/844 38/18639 0.0526315789473684 1.16232227488152 0.518514219410745 0.839355140294736 GO:0043531 ADP binding 2/844 38/18639 0.0526315789473684 1.16232227488152 0.518514219410745 0.839355140294736 GO:0005254 chloride channel activity 4/844 83/18639 0.0481927710843374 1.06429509507223 0.521924119636608 0.839355140294736 GO:0030165 PDZ domain binding 4/844 83/18639 0.0481927710843374 1.06429509507223 0.521924119636608 0.839355140294736 GO:0000062 fatty-acyl-CoA binding 1/844 16/18639 0.0625 1.3802577014218 0.52370781528983 0.839355140294736 GO:0004708 MAP kinase kinase activity 1/844 16/18639 0.0625 1.3802577014218 0.52370781528983 0.839355140294736 GO:0005024 transforming growth factor beta receptor activity 1/844 16/18639 0.0625 1.3802577014218 0.52370781528983 0.839355140294736 GO:0008142 oxysterol binding 1/844 16/18639 0.0625 1.3802577014218 0.52370781528983 0.839355140294736 GO:0015385 sodium:proton antiporter activity 1/844 16/18639 0.0625 1.3802577014218 0.52370781528983 0.839355140294736 GO:0015562 efflux transmembrane transporter activity 1/844 16/18639 0.0625 1.3802577014218 0.52370781528983 0.839355140294736 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/844 16/18639 0.0625 1.3802577014218 0.52370781528983 0.839355140294736 GO:0019841 retinol binding 1/844 16/18639 0.0625 1.3802577014218 0.52370781528983 0.839355140294736 GO:0030275 LRR domain binding 1/844 16/18639 0.0625 1.3802577014218 0.52370781528983 0.839355140294736 GO:0070411 I-SMAD binding 1/844 16/18639 0.0625 1.3802577014218 0.52370781528983 0.839355140294736 GO:0140327 flippase activity 1/844 16/18639 0.0625 1.3802577014218 0.52370781528983 0.839355140294736 GO:0140328 floppase activity 1/844 16/18639 0.0625 1.3802577014218 0.52370781528983 0.839355140294736 GO:0015291 secondary active transmembrane transporter activity 13/844 287/18639 0.0452961672473868 1.00032613900953 0.539805919166691 0.84570222133191 GO:0004550 nucleoside diphosphate kinase activity 1/844 17/18639 0.0588235294117647 1.2990660719264 0.545293521346608 0.84570222133191 GO:0005092 GDP-dissociation inhibitor activity 1/844 17/18639 0.0588235294117647 1.2990660719264 0.545293521346608 0.84570222133191 GO:0008484 sulfuric ester hydrolase activity 1/844 17/18639 0.0588235294117647 1.2990660719264 0.545293521346608 0.84570222133191 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/844 17/18639 0.0588235294117647 1.2990660719264 0.545293521346608 0.84570222133191 GO:0030548 acetylcholine receptor regulator activity 1/844 17/18639 0.0588235294117647 1.2990660719264 0.545293521346608 0.84570222133191 GO:0032183 SUMO binding 1/844 17/18639 0.0588235294117647 1.2990660719264 0.545293521346608 0.84570222133191 GO:0045125 bioactive lipid receptor activity 1/844 17/18639 0.0588235294117647 1.2990660719264 0.545293521346608 0.84570222133191 GO:0048038 quinone binding 1/844 17/18639 0.0588235294117647 1.2990660719264 0.545293521346608 0.84570222133191 GO:0051787 misfolded protein binding 1/844 17/18639 0.0588235294117647 1.2990660719264 0.545293521346608 0.84570222133191 GO:1901567 fatty acid derivative binding 1/844 17/18639 0.0588235294117647 1.2990660719264 0.545293521346608 0.84570222133191 GO:1990226 histone methyltransferase binding 1/844 17/18639 0.0588235294117647 1.2990660719264 0.545293521346608 0.84570222133191 GO:0019001 guanyl nucleotide binding 18/844 400/18639 0.045 0.993785545023697 0.545364058209609 0.84570222133191 GO:0032561 guanyl ribonucleotide binding 18/844 400/18639 0.045 0.993785545023697 0.545364058209609 0.84570222133191 GO:0004620 phospholipase activity 5/844 109/18639 0.0458715596330275 1.01303317535545 0.552483032630434 0.84570222133191 GO:0140996 histone H3 kinase activity 16/844 357/18639 0.0448179271708683 0.989764626229639 0.553332874241929 0.84570222133191 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 12/844 268/18639 0.0447761194029851 0.988841338332036 0.55769747365334 0.84570222133191 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 2/844 41/18639 0.0487804878048781 1.07727430354872 0.559796112606382 0.84570222133191 GO:0008227 G protein-coupled amine receptor activity 2/844 41/18639 0.0487804878048781 1.07727430354872 0.559796112606382 0.84570222133191 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/844 41/18639 0.0487804878048781 1.07727430354872 0.559796112606382 0.84570222133191 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/844 41/18639 0.0487804878048781 1.07727430354872 0.559796112606382 0.84570222133191 GO:0140318 protein transporter activity 2/844 41/18639 0.0487804878048781 1.07727430354872 0.559796112606382 0.84570222133191 GO:0140828 metal cation:monoatomic cation antiporter activity 2/844 41/18639 0.0487804878048781 1.07727430354872 0.559796112606382 0.84570222133191 GO:0004222 metalloendopeptidase activity 5/844 110/18639 0.0454545454545455 1.00382378285222 0.560670184029382 0.84570222133191 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0004706 JUN kinase kinase kinase activity 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0004970 glutamate-gated receptor activity 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0008308 voltage-gated monoatomic anion channel activity 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0008525 phosphatidylcholine transporter activity 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0016854 racemase and epimerase activity 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0017075 syntaxin-1 binding 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0017128 phospholipid scramblase activity 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0031690 adrenergic receptor binding 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0032393 MHC class I receptor activity 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0034185 apolipoprotein binding 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0050811 GABA receptor binding 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0070064 proline-rich region binding 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0098641 cadherin binding involved in cell-cell adhesion 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0099602 neurotransmitter receptor regulator activity 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:1901611 phosphatidylglycerol binding 1/844 18/18639 0.0555555555555556 1.22689573459716 0.565902063285361 0.84570222133191 GO:0035173 histone kinase activity 16/844 360/18639 0.0444444444444444 0.981516587677725 0.567004910988883 0.84570222133191 GO:0046873 metal ion transmembrane transporter activity 20/844 450/18639 0.0444444444444444 0.981516587677725 0.56708634121091 0.84570222133191 GO:0015297 antiporter activity 6/844 135/18639 0.0444444444444444 0.981516587677725 0.576992412641812 0.850438891094714 GO:0003756 protein disulfide isomerase activity 1/844 19/18639 0.0526315789473684 1.16232227488152 0.585577626283437 0.850438891094714 GO:0005229 intracellularly calcium-gated chloride channel activity 1/844 19/18639 0.0526315789473684 1.16232227488152 0.585577626283437 0.850438891094714 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/844 19/18639 0.0526315789473684 1.16232227488152 0.585577626283437 0.850438891094714 GO:0005520 insulin-like growth factor binding 1/844 19/18639 0.0526315789473684 1.16232227488152 0.585577626283437 0.850438891094714 GO:0008574 plus-end-directed microtubule motor activity 1/844 19/18639 0.0526315789473684 1.16232227488152 0.585577626283437 0.850438891094714 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/844 19/18639 0.0526315789473684 1.16232227488152 0.585577626283437 0.850438891094714 GO:0016918 retinal binding 1/844 19/18639 0.0526315789473684 1.16232227488152 0.585577626283437 0.850438891094714 GO:0022821 solute:potassium antiporter activity 1/844 19/18639 0.0526315789473684 1.16232227488152 0.585577626283437 0.850438891094714 GO:0042577 lipid phosphatase activity 1/844 19/18639 0.0526315789473684 1.16232227488152 0.585577626283437 0.850438891094714 GO:0042800 histone H3K4 methyltransferase activity 1/844 19/18639 0.0526315789473684 1.16232227488152 0.585577626283437 0.850438891094714 GO:0042834 peptidoglycan binding 1/844 19/18639 0.0526315789473684 1.16232227488152 0.585577626283437 0.850438891094714 GO:0046624 sphingolipid transporter activity 1/844 19/18639 0.0526315789473684 1.16232227488152 0.585577626283437 0.850438891094714 GO:0070003 threonine-type peptidase activity 1/844 19/18639 0.0526315789473684 1.16232227488152 0.585577626283437 0.850438891094714 GO:0097001 ceramide binding 1/844 19/18639 0.0526315789473684 1.16232227488152 0.585577626283437 0.850438891094714 GO:0120227 acyl-CoA binding 1/844 19/18639 0.0526315789473684 1.16232227488152 0.585577626283437 0.850438891094714 GO:0141147 intracellularly calcium-gated channel activity 1/844 19/18639 0.0526315789473684 1.16232227488152 0.585577626283437 0.850438891094714 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 3/844 67/18639 0.0447761194029851 0.988841338332036 0.590067602863602 0.854069020117507 GO:0015079 potassium ion transmembrane transporter activity 7/844 160/18639 0.04375 0.966180390995261 0.591031634085743 0.854069020117507 GO:0016922 nuclear receptor binding 6/844 137/18639 0.0437956204379562 0.967187878368561 0.591444182282345 0.854069020117507 GO:0072341 modified amino acid binding 4/844 91/18639 0.043956043956044 0.970730691109838 0.595165201113749 0.854069020117507 GO:0001223 transcription coactivator binding 2/844 44/18639 0.0454545454545455 1.00382378285222 0.59848672409896 0.854069020117507 GO:0043014 alpha-tubulin binding 2/844 44/18639 0.0454545454545455 1.00382378285222 0.59848672409896 0.854069020117507 GO:0005548 phospholipid transporter activity 3/844 68/18639 0.0441176470588235 0.974299553944801 0.600183876438361 0.854069020117507 GO:0030145 manganese ion binding 3/844 68/18639 0.0441176470588235 0.974299553944801 0.600183876438361 0.854069020117507 GO:0001972 retinoic acid binding 1/844 20/18639 0.05 1.10420616113744 0.604362399828914 0.854069020117507 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/844 20/18639 0.05 1.10420616113744 0.604362399828914 0.854069020117507 GO:0005326 neurotransmitter transmembrane transporter activity 1/844 20/18639 0.05 1.10420616113744 0.604362399828914 0.854069020117507 GO:0010851 cyclase regulator activity 1/844 20/18639 0.05 1.10420616113744 0.604362399828914 0.854069020117507 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/844 20/18639 0.05 1.10420616113744 0.604362399828914 0.854069020117507 GO:0030742 GTP-dependent protein binding 1/844 20/18639 0.05 1.10420616113744 0.604362399828914 0.854069020117507 GO:0042288 MHC class I protein binding 1/844 20/18639 0.05 1.10420616113744 0.604362399828914 0.854069020117507 GO:0043024 ribosomal small subunit binding 1/844 20/18639 0.05 1.10420616113744 0.604362399828914 0.854069020117507 GO:0052745 inositol phosphate phosphatase activity 1/844 20/18639 0.05 1.10420616113744 0.604362399828914 0.854069020117507 GO:0140939 histone H4 methyltransferase activity 1/844 20/18639 0.05 1.10420616113744 0.604362399828914 0.854069020117507 GO:0051213 dioxygenase activity 4/844 93/18639 0.043010752688172 0.949854762268766 0.612401173037079 0.864135586467867 GO:0042562 hormone binding 4/844 94/18639 0.0425531914893617 0.93974992437229 0.620846987585102 0.866442558056298 GO:0005123 death receptor binding 1/844 21/18639 0.0476190476190476 1.05162491536899 0.622296667756536 0.866442558056298 GO:0005248 voltage-gated sodium channel activity 1/844 21/18639 0.0476190476190476 1.05162491536899 0.622296667756536 0.866442558056298 GO:0008373 sialyltransferase activity 1/844 21/18639 0.0476190476190476 1.05162491536899 0.622296667756536 0.866442558056298 GO:0015125 bile acid transmembrane transporter activity 1/844 21/18639 0.0476190476190476 1.05162491536899 0.622296667756536 0.866442558056298 GO:0036122 BMP binding 1/844 21/18639 0.0476190476190476 1.05162491536899 0.622296667756536 0.866442558056298 GO:0051010 microtubule plus-end binding 1/844 21/18639 0.0476190476190476 1.05162491536899 0.622296667756536 0.866442558056298 GO:0051428 peptide hormone receptor binding 1/844 21/18639 0.0476190476190476 1.05162491536899 0.622296667756536 0.866442558056298 GO:0061891 calcium ion sensor activity 1/844 21/18639 0.0476190476190476 1.05162491536899 0.622296667756536 0.866442558056298 GO:0016874 ligase activity 7/844 167/18639 0.0419161676646707 0.925681811731986 0.636110364510908 0.879900052696206 GO:0005243 gap junction channel activity 1/844 22/18639 0.0454545454545455 1.00382378285222 0.639418894226268 0.879900052696206 GO:0008970 phospholipase A1 activity 1/844 22/18639 0.0454545454545455 1.00382378285222 0.639418894226268 0.879900052696206 GO:0015377 chloride:monoatomic cation symporter activity 1/844 22/18639 0.0454545454545455 1.00382378285222 0.639418894226268 0.879900052696206 GO:0034062 5'-3' RNA polymerase activity 1/844 22/18639 0.0454545454545455 1.00382378285222 0.639418894226268 0.879900052696206 GO:0070034 telomerase RNA binding 1/844 22/18639 0.0454545454545455 1.00382378285222 0.639418894226268 0.879900052696206 GO:0097747 RNA polymerase activity 1/844 22/18639 0.0454545454545455 1.00382378285222 0.639418894226268 0.879900052696206 GO:0140784 metal ion sensor activity 1/844 22/18639 0.0454545454545455 1.00382378285222 0.639418894226268 0.879900052696206 GO:0004521 RNA endonuclease activity 3/844 73/18639 0.0410958904109589 0.907566707784198 0.648255512945634 0.890761578196039 GO:0003712 transcription coregulator activity 21/844 495/18639 0.0424242424242424 0.936902197328738 0.652835216910253 0.89261903742295 GO:0008170 N-methyltransferase activity 4/844 98/18639 0.0408163265306122 0.901392784601992 0.65345113209297 0.89261903742295 GO:0000295 adenine nucleotide transmembrane transporter activity 1/844 23/18639 0.0434782608695652 0.960179270554296 0.655765805827119 0.89261903742295 GO:0005212 structural constituent of eye lens 1/844 23/18639 0.0434782608695652 0.960179270554296 0.655765805827119 0.89261903742295 GO:0016493 C-C chemokine receptor activity 1/844 23/18639 0.0434782608695652 0.960179270554296 0.655765805827119 0.89261903742295 GO:0099186 structural constituent of postsynapse 1/844 23/18639 0.0434782608695652 0.960179270554296 0.655765805827119 0.89261903742295 GO:0008236 serine-type peptidase activity 8/844 194/18639 0.0412371134020619 0.910685493721601 0.656503204099762 0.89261903742295 GO:0001222 transcription corepressor binding 2/844 49/18639 0.0408163265306122 0.901392784601992 0.657171854882362 0.89261903742295 GO:0019003 GDP binding 3/844 75/18639 0.04 0.883364928909953 0.666294565754375 0.90370987079329 GO:0032813 tumor necrosis factor receptor superfamily binding 2/844 50/18639 0.04 0.883364928909953 0.668049970107412 0.904102156436123 GO:0004622 lysophospholipase activity 1/844 24/18639 0.0416666666666667 0.920171800947867 0.671372469980638 0.904102156436123 GO:0005315 phosphate transmembrane transporter activity 1/844 24/18639 0.0416666666666667 0.920171800947867 0.671372469980638 0.904102156436123 GO:0019957 C-C chemokine binding 1/844 24/18639 0.0416666666666667 0.920171800947867 0.671372469980638 0.904102156436123 GO:0070300 phosphatidic acid binding 1/844 24/18639 0.0416666666666667 0.920171800947867 0.671372469980638 0.904102156436123 GO:0003823 antigen binding 7/844 174/18639 0.0402298850574713 0.888441738846217 0.678211767913508 0.904609599183019 GO:0016830 carbon-carbon lyase activity 2/844 51/18639 0.0392156862745098 0.866044047950934 0.678647301143593 0.904609599183019 GO:0017171 serine hydrolase activity 8/844 198/18639 0.0404040404040404 0.89228780697975 0.678694549926495 0.904609599183019 GO:0004721 phosphoprotein phosphatase activity 7/844 175/18639 0.04 0.883364928909953 0.683968998667113 0.904609599183019 GO:0000030 mannosyltransferase activity 1/844 25/18639 0.04 0.883364928909953 0.686272369810686 0.904609599183019 GO:0004709 MAP kinase kinase kinase activity 1/844 25/18639 0.04 0.883364928909953 0.686272369810686 0.904609599183019 GO:0005251 delayed rectifier potassium channel activity 1/844 25/18639 0.04 0.883364928909953 0.686272369810686 0.904609599183019 GO:0015271 outward rectifier potassium channel activity 1/844 25/18639 0.04 0.883364928909953 0.686272369810686 0.904609599183019 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/844 25/18639 0.04 0.883364928909953 0.686272369810686 0.904609599183019 GO:0015645 fatty acid ligase activity 1/844 25/18639 0.04 0.883364928909953 0.686272369810686 0.904609599183019 GO:0120515 fatty acid-CoA ligase activity 1/844 25/18639 0.04 0.883364928909953 0.686272369810686 0.904609599183019 GO:0022836 gated channel activity 13/844 318/18639 0.0408805031446541 0.902810068854511 0.686768843958882 0.904609599183019 GO:0004519 endonuclease activity 5/844 127/18639 0.0393700787401575 0.869453670186961 0.68694142278157 0.904609599183019 GO:0004252 serine-type endopeptidase activity 7/844 176/18639 0.0397727272727273 0.878345809995691 0.689660378802459 0.904609599183019 GO:0043021 ribonucleoprotein complex binding 7/844 177/18639 0.0395480225988701 0.873383404289501 0.695285512332714 0.904609599183019 GO:0016791 phosphatase activity 11/844 273/18639 0.0402930402930403 0.889836466850685 0.696630654157049 0.904609599183019 GO:0008146 sulfotransferase activity 2/844 53/18639 0.0377358490566038 0.833363140481087 0.699012273158569 0.904609599183019 GO:0017046 peptide hormone binding 2/844 53/18639 0.0377358490566038 0.833363140481087 0.699012273158569 0.904609599183019 GO:0015370 solute:sodium symporter activity 3/844 79/18639 0.0379746835443038 0.838637590737297 0.700322649018456 0.904609599183019 GO:0016835 carbon-oxygen lyase activity 3/844 79/18639 0.0379746835443038 0.838637590737297 0.700322649018456 0.904609599183019 GO:0001637 G protein-coupled chemoattractant receptor activity 1/844 26/18639 0.0384615384615385 0.849389354721108 0.700497475638545 0.904609599183019 GO:0004950 chemokine receptor activity 1/844 26/18639 0.0384615384615385 0.849389354721108 0.700497475638545 0.904609599183019 GO:0005112 Notch binding 1/844 26/18639 0.0384615384615385 0.849389354721108 0.700497475638545 0.904609599183019 GO:0008066 glutamate receptor activity 1/844 26/18639 0.0384615384615385 0.849389354721108 0.700497475638545 0.904609599183019 GO:0008157 protein phosphatase 1 binding 1/844 26/18639 0.0384615384615385 0.849389354721108 0.700497475638545 0.904609599183019 GO:0015216 purine nucleotide transmembrane transporter activity 1/844 26/18639 0.0384615384615385 0.849389354721108 0.700497475638545 0.904609599183019 GO:0051139 metal cation:proton antiporter activity 1/844 26/18639 0.0384615384615385 0.849389354721108 0.700497475638545 0.904609599183019 GO:0052742 phosphatidylinositol kinase activity 1/844 26/18639 0.0384615384615385 0.849389354721108 0.700497475638545 0.904609599183019 GO:0097602 cullin family protein binding 1/844 26/18639 0.0384615384615385 0.849389354721108 0.700497475638545 0.904609599183019 GO:0120014 phospholipid transfer activity 1/844 26/18639 0.0384615384615385 0.849389354721108 0.700497475638545 0.904609599183019 GO:0005506 iron ion binding 6/844 154/18639 0.038961038961039 0.860420385301902 0.702810695142355 0.906356962041507 GO:0016298 lipase activity 5/844 130/18639 0.0384615384615385 0.849389354721108 0.706460278925031 0.908476991526987 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 2/844 54/18639 0.037037037037037 0.817930489731438 0.708786951622685 0.908476991526987 GO:0051287 NAD binding 2/844 54/18639 0.037037037037037 0.817930489731438 0.708786951622685 0.908476991526987 GO:0008017 microtubule binding 11/844 276/18639 0.0398550724637681 0.880164331341438 0.710033609214602 0.908476991526987 GO:0003714 transcription corepressor activity 8/844 204/18639 0.0392156862745098 0.866044047950934 0.71027934474696 0.908476991526987 GO:0016853 isomerase activity 7/844 180/18639 0.0388888888888889 0.85882701421801 0.711760133533277 0.908476991526987 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/844 27/18639 0.037037037037037 0.817930489731438 0.714078313255322 0.908476991526987 GO:0016405 CoA-ligase activity 1/844 27/18639 0.037037037037037 0.817930489731438 0.714078313255322 0.908476991526987 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/844 27/18639 0.037037037037037 0.817930489731438 0.714078313255322 0.908476991526987 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/844 27/18639 0.037037037037037 0.817930489731438 0.714078313255322 0.908476991526987 GO:0015101 organic cation transmembrane transporter activity 3/844 81/18639 0.037037037037037 0.817930489731438 0.71631872448086 0.91010077511431 GO:0005242 inward rectifier potassium channel activity 1/844 28/18639 0.0357142857142857 0.788718686526743 0.727044029116729 0.917107716704346 GO:0045499 chemorepellent activity 1/844 28/18639 0.0357142857142857 0.788718686526743 0.727044029116729 0.917107716704346 GO:0051393 alpha-actinin binding 1/844 28/18639 0.0357142857142857 0.788718686526743 0.727044029116729 0.917107716704346 GO:0051959 dynein light intermediate chain binding 1/844 28/18639 0.0357142857142857 0.788718686526743 0.727044029116729 0.917107716704346 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/844 28/18639 0.0357142857142857 0.788718686526743 0.727044029116729 0.917107716704346 GO:0003713 transcription coactivator activity 10/844 256/18639 0.0390625 0.862661063388626 0.727662796410546 0.917107716704346 GO:0141003 histone H2AX kinase activity 14/844 354/18639 0.0395480225988701 0.873383404289501 0.735936687292044 0.926298977071586 GO:0003924 GTPase activity 13/844 331/18639 0.0392749244712991 0.867352271588322 0.739387544730017 0.929403251964229 GO:0015276 ligand-gated monoatomic ion channel activity 7/844 186/18639 0.0376344086021505 0.83112291698517 0.742886466944556 0.930108979313612 GO:0099094 ligand-gated monoatomic cation channel activity 5/844 136/18639 0.0367647058823529 0.811916294954001 0.74289910451288 0.930108979313612 GO:0004175 endopeptidase activity 16/844 405/18639 0.0395061728395062 0.872459189046867 0.747678604784825 0.930108979313612 GO:0008234 cysteine-type peptidase activity 7/844 187/18639 0.0374331550802139 0.82667840940771 0.747836627226892 0.930108979313612 GO:0015215 nucleotide transmembrane transporter activity 1/844 30/18639 0.0333333333333333 0.736137440758294 0.751240155447121 0.930108979313612 GO:0016769 transferase activity, transferring nitrogenous groups 1/844 30/18639 0.0333333333333333 0.736137440758294 0.751240155447121 0.930108979313612 GO:0031210 phosphatidylcholine binding 1/844 30/18639 0.0333333333333333 0.736137440758294 0.751240155447121 0.930108979313612 GO:0031624 ubiquitin conjugating enzyme binding 1/844 30/18639 0.0333333333333333 0.736137440758294 0.751240155447121 0.930108979313612 GO:0048019 receptor antagonist activity 1/844 30/18639 0.0333333333333333 0.736137440758294 0.751240155447121 0.930108979313612 GO:0098918 structural constituent of synapse 1/844 30/18639 0.0333333333333333 0.736137440758294 0.751240155447121 0.930108979313612 GO:0043022 ribosome binding 4/844 112/18639 0.0357142857142857 0.788718686526743 0.752244873412405 0.930108979313612 GO:0022834 ligand-gated channel activity 7/844 188/18639 0.0372340425531915 0.822281183825754 0.752718893869689 0.930108979313612 GO:0001786 phosphatidylserine binding 2/844 59/18639 0.0338983050847458 0.748614346533858 0.753742975820883 0.930108979313612 GO:0070063 RNA polymerase binding 2/844 59/18639 0.0338983050847458 0.748614346533858 0.753742975820883 0.930108979313612 GO:0001098 basal transcription machinery binding 2/844 60/18639 0.0333333333333333 0.736137440758294 0.761981490267671 0.931204719361828 GO:0001099 basal RNA polymerase II transcription machinery binding 2/844 60/18639 0.0333333333333333 0.736137440758294 0.761981490267671 0.931204719361828 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 2/844 60/18639 0.0333333333333333 0.736137440758294 0.761981490267671 0.931204719361828 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/844 31/18639 0.032258064516129 0.712391071701575 0.762522508545225 0.931204719361828 GO:0005452 solute:inorganic anion antiporter activity 1/844 31/18639 0.032258064516129 0.712391071701575 0.762522508545225 0.931204719361828 GO:0016878 acid-thiol ligase activity 1/844 31/18639 0.032258064516129 0.712391071701575 0.762522508545225 0.931204719361828 GO:0047499 calcium-independent phospholipase A2 activity 1/844 31/18639 0.032258064516129 0.712391071701575 0.762522508545225 0.931204719361828 GO:0072349 modified amino acid transmembrane transporter activity 1/844 31/18639 0.032258064516129 0.712391071701575 0.762522508545225 0.931204719361828 GO:0016836 hydro-lyase activity 2/844 61/18639 0.0327868852459016 0.724069613860617 0.769979942907896 0.938289571852387 GO:0030515 snoRNA binding 1/844 32/18639 0.03125 0.6901288507109 0.773293736124107 0.938289571852387 GO:0031369 translation initiation factor binding 1/844 32/18639 0.03125 0.6901288507109 0.773293736124107 0.938289571852387 GO:0047498 calcium-dependent phospholipase A2 activity 1/844 32/18639 0.03125 0.6901288507109 0.773293736124107 0.938289571852387 GO:0051059 NF-kappaB binding 1/844 32/18639 0.03125 0.6901288507109 0.773293736124107 0.938289571852387 GO:0015294 solute:monoatomic cation symporter activity 4/844 116/18639 0.0344827586206897 0.761521490439614 0.77612009670552 0.940510104351747 GO:0030296 protein tyrosine kinase activator activity 1/844 33/18639 0.0303030303030303 0.669215855234813 0.783576967526872 0.947114798137474 GO:0071889 14-3-3 protein binding 1/844 33/18639 0.0303030303030303 0.669215855234813 0.783576967526872 0.947114798137474 GO:0008376 acetylgalactosaminyltransferase activity 1/844 34/18639 0.0294117647058824 0.6495330359632 0.79339428663938 0.954094530684808 GO:0015020 glucuronosyltransferase activity 1/844 34/18639 0.0294117647058824 0.6495330359632 0.79339428663938 0.954094530684808 GO:0015035 protein-disulfide reductase activity 1/844 34/18639 0.0294117647058824 0.6495330359632 0.79339428663938 0.954094530684808 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/844 34/18639 0.0294117647058824 0.6495330359632 0.79339428663938 0.954094530684808 GO:0160215 deacylase activity 2/844 65/18639 0.0307692307692308 0.679511483776887 0.799670256720462 0.959972180835927 GO:0004623 phospholipase A2 activity 1/844 35/18639 0.0285714285714286 0.630974949221395 0.802766779091751 0.959972180835927 GO:0061631 ubiquitin conjugating enzyme activity 1/844 35/18639 0.0285714285714286 0.630974949221395 0.802766779091751 0.959972180835927 GO:0004540 RNA nuclease activity 4/844 121/18639 0.0330578512396694 0.730053660256159 0.803366549640236 0.959972180835927 GO:0051082 unfolded protein binding 4/844 121/18639 0.0330578512396694 0.730053660256159 0.803366549640236 0.959972180835927 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/844 122/18639 0.0327868852459016 0.724069613860617 0.808480507643125 0.963847246541692 GO:0022832 voltage-gated channel activity 6/844 175/18639 0.0342857142857143 0.757169939065674 0.809369527090772 0.963847246541692 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/844 36/18639 0.0277777777777778 0.613447867298578 0.811714577331192 0.963847246541692 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/844 36/18639 0.0277777777777778 0.613447867298578 0.811714577331192 0.963847246541692 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/844 36/18639 0.0277777777777778 0.613447867298578 0.811714577331192 0.963847246541692 GO:0042054 histone methyltransferase activity 2/844 67/18639 0.0298507462686567 0.659227558888024 0.813202321189503 0.9644007427172 GO:0005525 GTP binding 14/844 378/18639 0.037037037037037 0.817930489731438 0.815462011893728 0.965867175944391 GO:0005267 potassium channel activity 4/844 124/18639 0.032258064516129 0.712391071701575 0.818382986989675 0.967855347677318 GO:1990841 promoter-specific chromatin binding 2/844 68/18639 0.0294117647058824 0.6495330359632 0.819657425575902 0.967855347677318 GO:0030280 structural constituent of skin epidermis 1/844 37/18639 0.027027027027027 0.596868195209427 0.820256903662024 0.967855347677318 GO:0030594 neurotransmitter receptor activity 3/844 97/18639 0.0309278350515464 0.683014120291201 0.821241666832131 0.967855347677318 GO:0016279 protein-lysine N-methyltransferase activity 2/844 69/18639 0.0289855072463768 0.640119513702864 0.825911835320286 0.972145601673754 GO:0016278 lysine N-methyltransferase activity 2/844 70/18639 0.0285714285714286 0.630974949221395 0.831970464149552 0.976840942981563 GO:0016782 transferase activity, transferring sulphur-containing groups 2/844 70/18639 0.0285714285714286 0.630974949221395 0.831970464149552 0.976840942981563 GO:0000217 DNA secondary structure binding 1/844 39/18639 0.0256410256410256 0.566259569814072 0.836197723839801 0.978154462583361 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/844 39/18639 0.0256410256410256 0.566259569814072 0.836197723839801 0.978154462583361 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/844 39/18639 0.0256410256410256 0.566259569814072 0.836197723839801 0.978154462583361 GO:0004518 nuclease activity 7/844 209/18639 0.0334928229665072 0.739659629470056 0.839937443962479 0.981313053342302 GO:0015036 disulfide oxidoreductase activity 1/844 40/18639 0.025 0.55210308056872 0.843630472284919 0.981981708800202 GO:0050997 quaternary ammonium group binding 1/844 40/18639 0.025 0.55210308056872 0.843630472284919 0.981981708800202 GO:0140662 ATP-dependent protein folding chaperone 1/844 40/18639 0.025 0.55210308056872 0.843630472284919 0.981981708800202 GO:0001727 lipid kinase activity 1/844 41/18639 0.024390243902439 0.538637151774361 0.850726331276883 0.987805235824573 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/844 41/18639 0.024390243902439 0.538637151774361 0.850726331276883 0.987805235824573 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 4/844 132/18639 0.0303030303030303 0.669215855234813 0.85385419756698 0.989584990308548 GO:0004520 DNA endonuclease activity 1/844 42/18639 0.0238095238095238 0.525812457684496 0.857500553042788 0.989584990308548 GO:0008307 structural constituent of muscle 1/844 42/18639 0.0238095238095238 0.525812457684496 0.857500553042788 0.989584990308548 GO:0016859 cis-trans isomerase activity 1/844 42/18639 0.0238095238095238 0.525812457684496 0.857500553042788 0.989584990308548 GO:0031492 nucleosomal DNA binding 1/844 42/18639 0.0238095238095238 0.525812457684496 0.857500553042788 0.989584990308548 GO:0044183 protein folding chaperone 2/844 75/18639 0.0266666666666667 0.588909952606635 0.859496190967321 0.990676928294446 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/844 43/18639 0.0232558139534884 0.513584260994159 0.863967700068217 0.993405004706938 GO:0005245 voltage-gated calcium channel activity 1/844 43/18639 0.0232558139534884 0.513584260994159 0.863967700068217 0.993405004706938 GO:0019205 nucleobase-containing compound kinase activity 1/844 44/18639 0.0227272727272727 0.501911891426109 0.870141676253548 0.99928679122062 GO:0030291 protein serine/threonine kinase inhibitor activity 1/844 46/18639 0.0217391304347826 0.480089635277148 0.881662615940369 0.99999985032179 GO:0043495 protein-membrane adaptor activity 1/844 47/18639 0.0212765957446809 0.469874962186145 0.887034355420083 0.99999985032179 GO:0061733 protein-lysine-acetyltransferase activity 1/844 47/18639 0.0212765957446809 0.469874962186145 0.887034355420083 0.99999985032179 GO:0099095 ligand-gated monoatomic anion channel activity 1/844 47/18639 0.0212765957446809 0.469874962186145 0.887034355420083 0.99999985032179 GO:0140938 histone H3 methyltransferase activity 1/844 47/18639 0.0212765957446809 0.469874962186145 0.887034355420083 0.99999985032179 GO:0033192 calmodulin-dependent protein phosphatase activity 2/844 81/18639 0.0246913580246914 0.545286993154292 0.887053959615836 0.99999985032179 GO:0140791 histone H2AXS140 phosphatase activity 2/844 81/18639 0.0246913580246914 0.545286993154292 0.887053959615836 0.99999985032179 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 2/844 81/18639 0.0246913580246914 0.545286993154292 0.887053959615836 0.99999985032179 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 2/844 81/18639 0.0246913580246914 0.545286993154292 0.887053959615836 0.99999985032179 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 2/844 81/18639 0.0246913580246914 0.545286993154292 0.887053959615836 0.99999985032179 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 2/844 81/18639 0.0246913580246914 0.545286993154292 0.887053959615836 0.99999985032179 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 2/844 81/18639 0.0246913580246914 0.545286993154292 0.887053959615836 0.99999985032179 GO:1990439 MAP kinase serine/threonine phosphatase activity 2/844 81/18639 0.0246913580246914 0.545286993154292 0.887053959615836 0.99999985032179 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 2/844 82/18639 0.024390243902439 0.538637151774361 0.891128678639506 0.99999985032179 GO:0033549 MAP kinase phosphatase activity 2/844 82/18639 0.024390243902439 0.538637151774361 0.891128678639506 0.99999985032179 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 1/844 48/18639 0.0208333333333333 0.460085900473934 0.892162529044516 0.99999985032179 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 2/844 83/18639 0.0240963855421687 0.532147547536116 0.895066535170538 0.99999985032179 GO:0005244 voltage-gated monoatomic ion channel activity 5/844 173/18639 0.0289017341040462 0.638269457304879 0.896974707184006 0.99999985032179 GO:0004527 exonuclease activity 2/844 84/18639 0.0238095238095238 0.525812457684496 0.89887155045652 0.99999985032179 GO:0017018 myosin phosphatase activity 2/844 84/18639 0.0238095238095238 0.525812457684496 0.89887155045652 0.99999985032179 GO:0000287 magnesium ion binding 7/844 230/18639 0.0304347826086957 0.672125489388007 0.900703701656776 0.99999985032179 GO:0015605 organophosphate ester transmembrane transporter activity 1/844 50/18639 0.02 0.441682464454976 0.901731804783074 0.99999985032179 GO:0015293 symporter activity 4/844 146/18639 0.0273972602739726 0.605044471856132 0.901808562168659 0.99999985032179 GO:0005048 signal sequence binding 1/844 51/18639 0.0196078431372549 0.433022023975467 0.906193494855863 0.99999985032179 GO:0032182 ubiquitin-like protein binding 3/844 120/18639 0.025 0.55210308056872 0.913179074744214 0.99999985032179 GO:0005544 calcium-dependent phospholipid binding 1/844 53/18639 0.0188679245283019 0.416681570240544 0.914519003803961 0.99999985032179 GO:0034212 protein N-acetyltransferase activity 1/844 53/18639 0.0188679245283019 0.416681570240544 0.914519003803961 0.99999985032179 GO:1901505 carbohydrate derivative transmembrane transporter activity 1/844 53/18639 0.0188679245283019 0.416681570240544 0.914519003803961 0.99999985032179 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/844 53/18639 0.0188679245283019 0.416681570240544 0.914519003803961 0.99999985032179 GO:0003925 G protein activity 1/844 54/18639 0.0185185185185185 0.408965244865719 0.91840074063757 0.99999985032179 GO:0050661 NADP binding 1/844 54/18639 0.0185185185185185 0.408965244865719 0.91840074063757 0.99999985032179 GO:0003774 cytoskeletal motor activity 4/844 153/18639 0.0261437908496732 0.577362698633956 0.920115814263115 0.99999985032179 GO:0052689 carboxylic ester hydrolase activity 2/844 92/18639 0.0217391304347826 0.480089635277148 0.924984297630367 0.99999985032179 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/844 56/18639 0.0178571428571429 0.394359343263372 0.925643974779498 0.99999985032179 GO:0015932 nucleobase-containing compound transmembrane transporter activity 1/844 57/18639 0.0175438596491228 0.387440758293839 0.929021065953479 0.99999985032179 GO:0004674 protein serine/threonine kinase activity 14/844 433/18639 0.0323325635103926 0.714036316670863 0.929448733712787 0.99999985032179 GO:0008276 protein methyltransferase activity 2/844 95/18639 0.0210526315789474 0.464928909952607 0.933025325372751 0.99999985032179 GO:0001653 peptide receptor activity 3/844 128/18639 0.0234375 0.517596638033175 0.933329703947832 0.99999985032179 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 3/844 128/18639 0.0234375 0.517596638033175 0.933329703947832 0.99999985032179 GO:0015459 potassium channel regulator activity 1/844 59/18639 0.0169491525423729 0.374307173266929 0.935322570626731 0.99999985032179 GO:0031593 polyubiquitin modification-dependent protein binding 1/844 59/18639 0.0169491525423729 0.374307173266929 0.935322570626731 0.99999985032179 GO:0036002 pre-mRNA binding 1/844 59/18639 0.0169491525423729 0.374307173266929 0.935322570626731 0.99999985032179 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3/844 130/18639 0.0230769230769231 0.509633612832665 0.937645279524737 0.99999985032179 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 1/844 60/18639 0.0166666666666667 0.368068720379147 0.938260555039596 0.99999985032179 GO:0106310 protein serine kinase activity 11/844 361/18639 0.0304709141274238 0.672923422299825 0.939764362380195 0.99999985032179 GO:0005249 voltage-gated potassium channel activity 2/844 98/18639 0.0204081632653061 0.450696392300996 0.940245724395024 0.99999985032179 GO:0019905 syntaxin binding 1/844 61/18639 0.0163934426229508 0.362034806930308 0.941065231908458 0.99999985032179 GO:0043130 ubiquitin binding 2/844 100/18639 0.02 0.441682464454976 0.944641832679086 0.99999985032179 GO:0022824 transmitter-gated monoatomic ion channel activity 1/844 63/18639 0.0158730158730159 0.35054163845633 0.946298556779008 0.99999985032179 GO:0022835 transmitter-gated channel activity 1/844 63/18639 0.0158730158730159 0.35054163845633 0.946298556779008 0.99999985032179 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 4/844 167/18639 0.0239520958083832 0.528961035275421 0.94782644865866 0.99999985032179 GO:0004536 DNA nuclease activity 1/844 64/18639 0.015625 0.34506442535545 0.948738480232847 0.99999985032179 GO:0004722 protein serine/threonine phosphatase activity 2/844 103/18639 0.0194174757281553 0.428817926655317 0.950663138943557 0.99999985032179 GO:0140767 enzyme-substrate adaptor activity 3/844 139/18639 0.0215827338129496 0.476635753008967 0.954048702063471 0.99999985032179 GO:0000149 SNARE binding 2/844 106/18639 0.0188679245283019 0.416681570240544 0.956056215870682 0.99999985032179 GO:0140030 modification-dependent protein binding 4/844 173/18639 0.023121387283237 0.510615565843903 0.95674896888298 0.99999985032179 GO:0003777 microtubule motor activity 1/844 68/18639 0.0147058823529412 0.3247665179816 0.957439920668392 0.99999985032179 GO:0004843 cysteine-type deubiquitinase activity 2/844 108/18639 0.0185185185185185 0.408965244865719 0.959333134852261 0.99999985032179 GO:0008080 N-acetyltransferase activity 1/844 69/18639 0.0144927536231884 0.320059756851432 0.959374157217629 0.99999985032179 GO:0098960 postsynaptic neurotransmitter receptor activity 1/844 69/18639 0.0144927536231884 0.320059756851432 0.959374157217629 0.99999985032179 GO:0022843 voltage-gated monoatomic cation channel activity 3/844 143/18639 0.020979020979021 0.463303284393332 0.95996024564058 0.99999985032179 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/844 73/18639 0.0136986301369863 0.302522235928066 0.966271962943291 0.99999985032179 GO:0003684 damaged DNA binding 1/844 74/18639 0.0135135135135135 0.298434097604714 0.967805220687332 0.99999985032179 GO:0031491 nucleosome binding 1/844 74/18639 0.0135135135135135 0.298434097604714 0.967805220687332 0.99999985032179 GO:0019842 vitamin binding 3/844 150/18639 0.02 0.441682464454976 0.968622777018398 0.99999985032179 GO:0016741 transferase activity, transferring one-carbon groups 5/844 215/18639 0.0232558139534884 0.513584260994159 0.968875775272916 0.99999985032179 GO:0101005 deubiquitinase activity 2/844 115/18639 0.0173913043478261 0.384071708221718 0.969053862842927 0.99999985032179 GO:0035403 histone H3T6 kinase activity 6/844 247/18639 0.0242914979757085 0.5364564345607 0.970013834743293 0.99999985032179 GO:0051536 iron-sulfur cluster binding 1/844 76/18639 0.0131578947368421 0.290580568720379 0.97066602738046 0.99999985032179 GO:0140104 molecular carrier activity 6/844 249/18639 0.0240963855421687 0.532147547536116 0.971679150320126 0.99999985032179 GO:0051540 metal cluster binding 1/844 77/18639 0.012987012987013 0.286806795100634 0.971999748917436 0.99999985032179 GO:0003697 single-stranded DNA binding 2/844 121/18639 0.0165289256198347 0.36502683012808 0.975568139010914 0.99999985032179 GO:0000049 tRNA binding 1/844 80/18639 0.0125 0.27605154028436 0.975648351357594 0.99999985032179 GO:0008528 G protein-coupled peptide receptor activity 2/844 122/18639 0.0163934426229508 0.362034806930308 0.976516261979498 0.99999985032179 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 2/844 122/18639 0.0163934426229508 0.362034806930308 0.976516261979498 0.99999985032179 GO:0019783 ubiquitin-like protein peptidase activity 2/844 127/18639 0.015748031496063 0.347781468074784 0.980747305212826 0.99999985032179 GO:0050660 flavin adenine dinucleotide binding 1/844 86/18639 0.0116279069767442 0.256792130497079 0.981582479935895 0.99999985032179 GO:0016757 glycosyltransferase activity 6/844 267/18639 0.0224719101123595 0.496272431971883 0.983256879407513 0.99999985032179 GO:0008168 methyltransferase activity 4/844 204/18639 0.0196078431372549 0.433022023975467 0.984245739804547 0.99999985032179 GO:0016410 N-acyltransferase activity 1/844 94/18639 0.0106382978723404 0.234937481093072 0.987310659464428 0.99999985032179 GO:0061659 ubiquitin-like protein ligase activity 9/844 372/18639 0.0241935483870968 0.534293303776181 0.988395870218357 0.99999985032179 GO:0016407 acetyltransferase activity 1/844 96/18639 0.0104166666666667 0.230042950236967 0.988439413580086 0.99999985032179 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3/844 181/18639 0.0165745856353591 0.366035191537273 0.989728464615363 0.99999985032179 GO:0008194 UDP-glycosyltransferase activity 2/844 145/18639 0.0137931034482759 0.304608596175846 0.990672037715445 0.99999985032179 GO:0061630 ubiquitin protein ligase activity 8/844 353/18639 0.0226628895184136 0.500490044708188 0.991569528161424 0.99999985032179 GO:0004497 monooxygenase activity 1/844 106/18639 0.00943396226415094 0.208340785120272 0.992745342766041 0.99999985032179 GO:0003730 mRNA 3'-UTR binding 5/844 262/18639 0.0190839694656489 0.421452733258565 0.992938860853944 0.99999985032179 GO:0016755 aminoacyltransferase activity 12/844 496/18639 0.0241935483870968 0.534293303776181 0.995290159142698 0.99999985032179 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 4/844 243/18639 0.0164609053497942 0.363524662102861 0.995915030486355 0.99999985032179 GO:0004676 3-phosphoinositide-dependent protein kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:0004711 ribosomal protein S6 kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:0035175 histone H3S10 kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:0035979 histone H2AXS139 kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:0044022 histone H3S28 kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:0044023 histone H4S1 kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:0044024 histone H2AS1 kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:0044025 histone H2BS14 kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:0072354 histone H3T3 kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:0072371 histone H2AS121 kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:0072518 Rho-dependent protein serine/threonine kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:0140823 histone H2BS36 kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:0140855 histone H3S57 kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:0140995 histone H2A kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:0140997 histone H4 kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:0140998 histone H2B kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:1990244 histone H2AT120 kinase activity 4/844 245/18639 0.0163265306122449 0.360557113840797 0.996195753599497 0.99999985032179 GO:0004677 DNA-dependent protein kinase activity 4/844 246/18639 0.016260162601626 0.359091434516241 0.996329035629123 0.99999985032179 GO:0140857 histone H3T45 kinase activity 4/844 246/18639 0.016260162601626 0.359091434516241 0.996329035629123 0.99999985032179 GO:0035402 histone H3T11 kinase activity 4/844 247/18639 0.0161943319838057 0.357637623040467 0.996457801038544 0.99999985032179 GO:0042393 histone binding 4/844 247/18639 0.0161943319838057 0.357637623040467 0.996457801038544 0.99999985032179 GO:0004679 AMP-activated protein kinase activity 4/844 248/18639 0.0161290322580645 0.356195535850787 0.996582196344312 0.99999985032179 GO:0019787 ubiquitin-like protein transferase activity 11/844 479/18639 0.022964509394572 0.507151055219701 0.996692600546781 0.99999985032179 GO:0016887 ATP hydrolysis activity 9/844 417/18639 0.0215827338129496 0.476635753008967 0.996705348280777 0.99999985032179 GO:0031490 chromatin DNA binding 1/844 128/18639 0.0078125 0.172532212677725 0.997399692850786 0.99999985032179 GO:0016779 nucleotidyltransferase activity 1/844 136/18639 0.00735294117647059 0.1623832589908 0.998209984942264 0.99999985032179 GO:0140101 catalytic activity, acting on a tRNA 1/844 139/18639 0.00719424460431655 0.158878584336322 0.998443944110108 0.99999985032179 GO:0004842 ubiquitin-protein transferase activity 9/844 449/18639 0.0200445434298441 0.442666167048417 0.998723139171037 0.99999985032179 GO:0016758 hexosyltransferase activity 2/844 197/18639 0.0101522842639594 0.224204296677653 0.998921111900015 0.99999985032179 GO:0140098 catalytic activity, acting on RNA 6/844 387/18639 0.0155038759689922 0.342389507329439 0.999664634518844 0.99999985032179 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 2/844 229/18639 0.00873362445414847 0.192874438626627 0.999723540953925 0.99999985032179 GO:0045182 translation regulator activity 4/844 356/18639 0.0112359550561798 0.248136215985942 0.999941339291851 0.99999985032179 GO:0140097 catalytic activity, acting on DNA 1/844 336/18639 0.00297619047619048 0.0657265572105619 0.99999985032179 0.99999985032179