category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	61/842	238/9376	2.85402902253538	F13A1/C1QA/FCGR2A/AGTR1/C1QC/CYBB/RPL23/RPL27A/C1QB/RPS11/CXCL8/SYK/RPS20/PRKCB/UBA52/RPS23/RPL13A/RPL23A/RPS14/C3AR1/RPLP2/RPL27/RPL15/RPLP1/RPS18/RPL38/RPS12/RPS15/RPL28/RPL35/RPS7/RPL26/RPS27A/NLRP3/RPL39/RPL14/RPL21/RPS17/RPS24/CFD/TLR2/IL6ST/TLR7/RPL18/RPS10/MMP1/RPL31/RPL9/RPL7/C2/CASP1/NRP1/RPL24/RPS6/PRKCA/RPS25/TNF/TLR4/ACE/OAS3/RPS16	9.10007128921891
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	54/842	212/9376	2.83637341460135	PLCB1/HGF/IGF1/KDR/FYB1/GNAI2/CSF1R/DOCK4/ID1/PRKCB/LCP2/P2RY1/FLT1/VAV3/RAPGEF5/PDGFC/SIPA1L2/RASGRP3/CTNNB1/TEK/AFDN/ITGB2/VAV1/MAGI1/FGFR3/EFNA5/GNAS/CDC42/ADCY4/CALM1/APBB1IP/RAPGEF1/MAGI3/PFN1/ITGAM/GNAQ/RAC2/MET/NRAS/LPAR5/FPR1/CDH1/PLCB2/PRKCA/RAPGEF2/SKAP1/CALM3/RALA/CTNND1/FGFR2/ITGAL/KIT/RAC1/RAPGEF3	8.49477248544963
NA	NA	hsa04517	IgSF CAM signaling	66/842	299/9376	2.4579794882387	MTSS1/CADM1/PTPRD/ROBO2/KDR/JAM2/LYN/PRKCB/LCP2/EZR/SLIT2/CADM3/EPB41L3/VAV3/ARPC3/INPP5D/CD28/CD86/ICAM2/CTNNB1/ARPC1B/AFDN/TUBA1B/KIRREL3/ITGB2/VAV1/MAGI1/ITGA4/IL1RAPL1/CD84/CD209/DOK2/CDC42/MYL12A/MYL12B/GRIP1/ROBO4/ITGAM/CADM2/GRB2/PAK4/TJP1/PTPN6/NCK2/RASA1/IL1RAPL2/ACTR2/ARPC2/NCAM2/LRRTM4/GRIP2/CLEC4M/NRP1/LMO7/SRGAP3/CDH1/PRKCA/RAPGEF2/SLAMF1/F11R/CASKIN2/GSK3B/ITGAL/RAC1/JAM3/CABLES1	8.04787468400042
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	33/842	116/9376	3.16782701285937	PECAM1/CYBA/CYBB/CDH5/JAM2/GNAI2/PRKCB/NCF4/EZR/VAV3/CTNNB1/AFDN/ITGB2/VAV1/ITGA4/CDC42/TXK/MYL12A/MYL12B/ITGAM/RAC2/NCF2/VCAM1/CLDN11/CXCR4/PRKCA/OCLN/F11R/CTNND1/ITGAL/RAC1/RAPGEF3/JAM3	7.37927150497456
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	45/842	205/9376	2.4443543247784	MT-CO2/COX4I2/PLCB1/MT-ATP6/MT-CYB/AGTR1/MT-ND1/CD36/MT-ND2/MT-CO3/CYBA/CYBB/MT-CO1/SLC2A1/MT-ND3/MT-ND5/MT-ND4/PRKCB/NCF4/ATP5F1E/NDUFA4L2/UQCR10/NDUFC2/TBC1D4/COX6C/RAC2/MT-ND6/PPP1CA/ATP5PF/UQCR11/UQCRB/NDUFA1/COX4I1/NCF2/COX8A/PLCB2/PRKCA/PARP1/ACE/NDUFB3/ATP5MC3/ATP5MC2/GSK3B/NDUFA13/RAC1	6.56761512941275
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	28/842	98/9376	3.18154054971157	MARCKS/FCGR2A/FCGR2B/FCGR3A/PTPRC/SYK/LYN/PRKCB/VAV3/ARPC3/INPP5D/FCGR1A/ARPC1B/VAV1/HCK/SCIN/CDC42/MYO10/WAS/BIN1/RAC2/ACTR2/ARPC2/LIMK2/PLD1/PRKCA/MARCKSL1/RAC1	6.81890293366749
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	18/842	50/9376	4.00874109263658	HBB/HBA2/HGF/HBA1/CD36/PECAM1/CR1/CXCL8/ITGB2/CR1L/TLR2/MET/VCAM1/KLRB1/TNF/TLR4/GYPB/ITGAL	6.70019556194408
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	32/842	138/9376	2.58211986643258	MT-CO2/COX4I2/MT-ATP6/MT-CYB/MT-ND1/MT-ND2/MT-CO3/MT-CO1/MT-ND3/MT-ND5/MT-ND4/ATP5F1E/NDUFA4L2/ATP5MG/UQCR10/NDUFC2/ATP6V1G1/ATP5MF/COX6C/MT-ND6/ATP5PF/UQCR11/UQCRB/NDUFA1/COX4I1/ATP6V0C/COX8A/NDUFB3/ATP5MC3/ATP5MC2/ATP6V1C2/NDUFA13	5.8810559736711
NA	NA	hsa04518	Integrin signaling	34/842	154/9376	2.45846315204985	SPP1/HGF/LAMA2/IGF1/CCND1/LAMC3/KDR/FLT1/ITGA9/PDGFC/FREM1/ICAM2/CTNNB1/ITGA6/ITGB2/ITGA4/CDC42/PARVB/ITGAM/RAC2/MET/COL4A5/ITGA2/NCK2/COL6A6/VCAM1/VTN/CCND2/ITGB4/CDH1/FERMT3/GSK3B/ITGAL/RAC1	5.73203227842781
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	39/842	193/9376	2.25015691728305	CXCL14/PLCB1/GNGT1/CCL3/CCL4/GNG11/CCL4L2/GNG2/ELMO1/CCL3L1/CXCL8/GNAI2/LYN/PRKCB/VAV3/DOCK2/PREX1/SOS1/CCR1/GNG10/VAV1/HCK/CDC42/ADCY4/WAS/GNG5/GNAQ/RAC2/GRB2/PIK3R5/NRAS/ARRB2/PIK3CG/GRK3/CX3CR1/CXCR4/PLCB2/GSK3B/RAC1	5.51208943216906
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	31/842	138/9376	2.50142862060656	FCGR2A/ELMO1/FYB1/CXCL8/LCP2/VAV3/ARPC3/ARPC1B/VAV1/ITGA4/RPS6KA2/PKN2/WIPF1/CDC42/NLRP3/SKAP2/WAS/CD4/GNAQ/RAC2/ACTR2/ARPC2/CASP1/GIT2/PYCARD/TNF/TLR4/RPS6KA1/GSK3B/ARHGEF12/RAC1	5.58111047437205
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	24/842	93/9376	2.87364952877174	CDH5/LEF1/PTPRB/CTNNB1/ARHGAP29/AFDN/PTPRJ/CDC42/MYL12A/MYL12B/WAS/RAC2/MET/TJP1/PTPN6/NLK/RASIP1/HEG1/LMO7/CDH1/RADIL/CTNND1/RAC1/YES1	5.70362576157886
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	40/842	204/9376	2.18341018117461	WNT2/HGF/IGF1/ITPR2/CCND1/LUM/KDR/HPSE2/GPC3/PRKCB/DCN/EZR/IGF2/VAV3/CTNNB1/SOS1/WNT3A/VAV1/FZD1/HCLS1/CDC42/TLR2/GRB2/MET/PPP1CA/WNT2B/ITGA2/PTPN6/TWIST1/PDCD4/NRAS/VTN/RPS6/PRKCA/TNF/TLR4/CTSL/ARHGEF12/RAC1/FZD2	5.36764427699609
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	33/842	155/9376	2.37076086123669	CD14/FCGR2A/CD36/CYBA/CYBB/FCGR2B/FCGR3A/MRC1/MSR1/COLEC12/SCARB1/NCF4/CLEC7A/FCGR1A/TUBA1B/CTSS/ITGB2/CORO1A/ATP6V1G1/CD209/CALR/STX7/TLR2/ITGAM/ITGA2/NCF2/ATP6V0C/CLEC4M/TLR6/TLR4/CTSL/ATP6V1C2/RAC1	5.40510205605622
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	37/842	184/9376	2.239182071672	ROBO2/SEMA3A/ABLIM3/GNAI2/SLIT2/SEMA6D/SSH2/EPHA3/NTNG1/EFNB2/ABLIM1/EFNA5/CDC42/MYL12A/MYL12B/SEMA3G/RAC2/MET/BMP7/PAK4/EPHA7/NCK2/NRAS/RASA1/PLXNC1/NRP1/FES/LIMK2/SRGAP3/EPHA4/CXCR4/BMPR2/PRKCA/EPHB4/GSK3B/ARHGEF12/RAC1	5.33217494442008
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	51/842	300/9376	1.89301662707838	AREG/CD14/HGF/IGF1/KDR/MEF2C/DUSP6/CSF1R/STMN1/PRKCB/FLT1/IGF2/PDGFC/DUSP9/RASGRP3/SOS1/TEK/MECOM/RASGRF2/MAP3K1/MKNK1/RPS6KA2/FGFR3/MAPT/EFNA5/CDC42/CACNB4/MAP4K2/RAC2/GRB2/MET/NLK/NRAS/RASA1/MAP3K11/DUSP4/CDC25B/ARRB2/TAOK2/MAP4K1/PRKCA/RAPGEF2/TNF/MAP2K5/CACNA1D/RPS6KA1/FGFR2/KIT/RASA2/RAC1/RPS6KA5	4.93785455429749
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	35/842	178/9376	2.18954335584083	PLCB1/WNT2/CCND1/LRP6/RSPO3/LEF1/RSPO2/PRKCB/CTNNB1/CTNNBIP1/PRICKLE1/WNT3A/GPC4/BAMBI/FZD1/VANGL2/RAC2/NOTUM/TLE4/WNT2B/SFRP1/NLK/LGR5/SOX17/CCND2/INVS/PLCB2/PRKCA/CCDC88C/GSK3B/RBX1/RAC1/CTBP1/FZD2/FRZB	5.03279150151975
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	41/842	227/9376	2.01123818891458	PLCB1/GNGT1/CCL3/CCL4/GNG11/B2M/CCL4L2/GNG2/CDK6/ITPR2/CCND1/CCL3L1/CXCL8/GNAI2/PRKCB/CTNNB1/SOS1/CCR1/GNG10/CALR/GNAS/ADCY4/CALM1/RB1/GNG5/GNAQ/RAC2/GRB2/IL10RA/NRAS/PTGER4/CXCR4/PLCB2/PRKCA/TNF/CALM3/IL10RB/GSK3B/EIF4EBP1/ARHGEF12/RAC1	4.84445517336072
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	42/842	238/9376	1.96506916305715	GNGT1/HGF/GNG11/GNG2/IGF1/KDR/CSF1R/RALGAPA2/PRKCB/FLT1/IGF2/RAPGEF5/PDGFC/RASGRP3/SOS1/TEK/RASGRF2/AFDN/GNG10/RGL1/PLA2G2A/FGFR3/EFNA5/CDC42/CALM1/PLAAT3/GNG5/RAC2/GRB2/MET/RASA4/PAK4/NRAS/RASA1/PLD1/PRKCA/CALM3/RALA/FGFR2/KIT/RASA2/RAC1	4.73681807355811
Organismal Systems	Immune system	hsa04611	Platelet activation	27/842	126/9376	2.38615541228368	PLCB1/FCGR2A/FCER1G/VAMP8/ITPR2/GUCY1A2/GNAI2/SYK/LYN/LCP2/P2RY1/TBXAS1/GNAS/ADCY4/MYL12A/MYL12B/APBB1IP/GNAQ/PPP1CA/ITGA2/PIK3R5/PIK3CG/TBXA2R/ORAI1/PLCB2/FERMT3/ARHGEF12	4.92030127529456
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	40/842	227/9376	1.96218359894106	MT-CO2/COX4I2/MT-ATP6/MT-CYB/HGF/MT-ND1/MT-ND2/MT-CO3/CYBA/MT-CO1/MT-ND3/MT-ND5/MGST2/MT-ND4/ATP5F1E/SOS1/NDUFA4L2/UQCR10/NDUFC2/PTPRJ/COX6C/MT-ND6/GRB2/MET/ATP5PF/UQCR11/UQCRB/NDUFA1/COX4I1/NRAS/NCF2/AHR/COX8A/SLC26A2/PLD1/NDUFB3/ATP5MC3/ATP5MC2/NDUFA13/RAC1	4.60945340544943
Organismal Systems	Endocrine system	hsa04924	Renin secretion	18/842	69/9376	2.90488484973665	PLCB1/AGTR1/ITPR2/ADRB1/GUCY1A2/GNAI2/PDE3B/GNAS/CALM1/GNAQ/NPR1/PTGER4/ORAI1/PLCB2/CACNA1D/CALM3/ACE/ADRB2	4.98831397192808
Genetic Information Processing	Translation	hsa03010	Ribosome	39/842	222/9376	1.95621750016049	RPL23/RPL27A/RPS11/RPS20/UBA52/RPS23/RPL13A/RPL23A/RPS14/RPLP2/RPL27/RPL15/RPLP1/RPS18/RPL38/RPS12/RPS15/RPL28/RPL35/RPS7/RPL26/RPS27A/RPL39/RPL14/RPL21/RPS17/RPS24/RPL18/RPS10/RPL31/MRPL17/RPL9/MRPS28/RPL7/RPL24/RPS6/RPS25/MRPS6/RPS16	4.52890369293745
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	56/842	362/9376	1.72260206558969	AREG/SPP1/GNGT1/HGF/LAMA2/GNG11/GNG2/IGF1/CSH1/CDK6/CCND1/LAMC3/KDR/LPAR6/CSF1R/SYK/FLT1/IGF2/ITGA9/PDGFC/SOS1/PIK3AP1/TEK/ITGA6/GNG10/MAGI1/ITGA4/FGFR3/PKN2/EFNA5/CSF3R/TLR2/GNG5/GRB2/MET/COL4A5/ITGA2/PIK3R5/NRAS/LPAR5/COL6A6/PIK3CG/VTN/CCND2/RPS6/YWHAE/ITGB4/YWHAB/PRKCA/TLR4/IL2RB/FGFR2/GSK3B/EIF4EBP1/KIT/RAC1	4.40412941067996
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	22/842	97/9376	2.525552807503	PLCB1/GNGT1/GNG11/GNG2/GUCY1A2/GNAI2/PRKCB/GNG10/RYR1/GNAS/ADCY4/CALM1/GNG5/GNAQ/KCNJ5/PLCB2/PRKCA/CACNA1D/CALM3/GRIN2C/RPS6KA5/GRIA4	4.74381659406666
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	45/842	275/9376	1.82215504210754	MT-CO2/COX4I2/C1QA/MT-ATP6/MT-CYB/MT-ND1/MT-ND2/C1QC/MT-CO3/CYBA/CYBB/MT-CO1/C1QB/ITPR2/MT-ND3/MT-ND5/MT-ND4/NCF4/ATP5F1E/NDUFA4L2/TUBA1B/UQCR10/NDUFC2/RYR1/COX6C/RAC2/MT-ND6/ATP5PF/UQCR11/UQCRB/NDUFA1/COX4I1/NCF2/NCAM2/COX8A/PSMA4/TNF/CACNA1D/GRIN2C/NDUFB3/ATP5MC3/ATP5MC2/GSK3B/NDUFA13/RAC1	4.34651196012863
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	36/842	203/9376	1.97474930671753	SPP1/HGF/LAMA2/IGF1/CCND1/LAMC3/KDR/PRKCB/FLT1/VAV3/ITGA9/PDGFC/CTNNB1/SOS1/ITGA6/VAV1/ITGA4/CDC42/MYL12A/PARVB/MYL12B/RAPGEF1/RAC2/GRB2/MET/PPP1CA/COL4A5/ITGA2/PAK4/COL6A6/VTN/CCND2/ITGB4/PRKCA/GSK3B/RAC1	4.41012218344506
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	40/842	235/9376	1.89538585940264	MT-CO2/COX4I2/MT-ATP6/MT-CYB/MT-ND1/MT-ND2/MT-CO3/MT-CO1/MT-ND3/MT-ND5/MT-ND4/ATP5F1E/SOS1/NDUFA4L2/ATP5MG/UQCR10/NDUFC2/RPS6KA2/PPARG/ATP5MF/GNAS/ADCY4/COX6C/MT-ND6/GRB2/NPR1/ATP5PF/UQCR11/UQCRB/NDUFA1/COX4I1/NRAS/COX16/COX8A/RPS6/RPS6KA1/NDUFB3/ATP5MC3/ATP5MC2/NDUFA13	4.36629095989936
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	12/842	37/9376	3.61147846183476	HBB/PLCB1/HBA2/IDO2/HBA1/PRKCB/IDO1/GNAQ/VCAM1/PLCB2/PRKCA/TNF	4.99922274256501
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	24/842	116/9376	2.30387419117045	PLCB1/GNGT1/GNG11/GNG2/ITPR2/GNAI2/PRKCB/GNG10/GNAS/SHANK3/ADCY4/GNG5/GNAQ/SHANK2/GRK3/GRIK4/PLD1/PLCB2/PRKCA/GRM7/CACNA1D/SLC1A3/GRIN2C/GRIA4	4.43838074159104
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	39/842	232/9376	1.87189778032599	TMSB4X/EZR/VAV3/ITGA9/PDGFC/ARPC3/IQGAP2/SSH2/SOS1/ITGA6/ARPC1B/ITGB2/VAV1/NCKAP1L/ITGA4/FGFR3/CHRM3/SCIN/CDC42/MYL12A/MYL12B/PFN1/ITGAM/RAC2/PPP1CA/ITGA2/PAK4/NRAS/LPAR5/ACTR2/ARPC2/LIMK2/ITGB4/CXCR4/FGD3/FGFR2/ITGAL/ARHGEF12/RAC1	4.22383379316625
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	20/842	89/9376	2.50233526381809	PLCB1/ITPR2/ADRB1/GUCY1A2/GNAI2/GJA1/PRKCB/PDGFC/SOS1/TUBA1B/GNAS/ADCY4/GNAQ/GRB2/TJP1/NRAS/CDK1/PLCB2/PRKCA/MAP2K5	4.47290327342454
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	27/842	140/9376	2.14753987105531	SPP1/PLCB1/GNGT1/AGTR1/GNG11/GNG2/APLNR/ITPR2/APLN/CCND1/MEF2C/GNAI2/GNG10/PDE3B/RYR1/KLF2/ADCY4/CALM1/GNG5/GNAQ/PIK3R5/NRAS/PIK3CG/RPS6/CDH1/PLCB2/CALM3	4.2968995816057
NA	NA	hsa04519	Cadherin signaling	59/842	404/9376	1.62620822652336	WNT2/CDH5/KDR/LRP6/PCDH18/LEF1/KRT18/GJA1/PCDH12/VAV3/ARPC3/FMN1/CTNNB1/ARPC1B/PRICKLE1/AFDN/WNT3A/CDH19/VAV1/KRT8/DSP/KRT23/NCKAP1L/PCDH11X/PCDH17/WWC1/FZD1/CDC42/RERE/PCDH10/VANGL2/DSC2/MYO1F/RAC2/KRT7/CDH8/MET/PPP1CA/WNT2B/DCHS1/TJP1/NRAS/TMC6/ACTR2/ARPC2/MYO7A/TAOK2/TMC8/GABRA3/YWHAE/YWHAB/CDH1/KRT1/APH1A/CTNND1/KRT19/GSK3B/RAC1/FZD2	4.04138461145946
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	28/842	149/9376	2.09255687162238	PLCB1/GNGT1/MT-ND1/GNG11/MT-ND2/GNG2/ITPR2/MT-ND3/MT-ND5/MT-ND4/GNAI2/PRKCB/NDUFA4L2/GNG10/NDUFC2/ADCY4/GNG5/GNAQ/MT-ND6/NDUFA1/KCNJ5/GABRA3/PLCB2/PRKCA/CACNA1D/NDUFB3/NDUFA13/GRIA4	4.22252560188798
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	21/842	98/9376	2.38615541228368	PLCB1/AGTR1/ITPR2/SCARB1/ATP1B1/PRKCB/GNAS/ADCY4/CALM1/KCNK3/GNAQ/NPR1/ATP2B1/KCNJ5/ORAI1/NR4A2/PLCB2/PRKCA/CACNA1D/CALM3/ATP1B3	4.33274513672915
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	18/842	78/9376	2.56970582861319	C1QA/CD14/C1QC/C1QB/CXCL8/GNAI2/LY96/ITGB2/CALM1/NLRP3/C4BPB/ITGAM/C2/CASP1/PYCARD/TNF/CALM3/TLR4	4.37256391098016
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	18/842	78/9376	2.56970582861319	FCGR2A/CYBA/CYBB/FCGR3A/CR1/PRKCB/NCF4/FCGR1A/ITGB2/CR1L/ITGA4/TLR2/ITGAM/PTPN6/NCF2/TNF/TLR4/MARCKSL1	4.37256391098016
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	36/842	216/9376	1.85589865399842	CD14/PLCB1/CCL3/CD36/CYBA/CYBB/CCL3L1/TNFSF10/CXCL8/LYN/NCF4/VAV3/LY96/VAV1/POU2F2/PPARG/CDC42/CALM1/NLRP3/TANK/TLR2/MMP1/NRAS/NCF2/VCAM1/CASP1/PYCARD/PLCB2/PRKCA/TLR6/TNF/CALM3/TLR4/GSK3B/RAC1/TNFRSF10A	3.99730095039171
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	20/842	95/9376	2.34429303662958	CCL3/CCL3L1/CXCL8/FLT1/CD28/CD86/TEK/ITGB2/TNFSF13B/ATP6V1G1/TNFRSF11A/TLR2/MMP1/ATP6V0C/LTB/TNF/TLR4/CTSL/ITGAL/ATP6V1C2	4.13641143460589
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/842	68/9376	2.62009221740953	CD14/CCND1/DUSP6/LEF1/CSF1R/FCGR1A/SOS1/SPI1/ITGAM/GRB2/NRAS/CEBPA/BCL2A1/EIF4EBP1/KIT/RUNX1T1	4.21144729012749
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	6/842	12/9376	5.56769596199525	FCGR2B/CD209/NCAM2/CLEC4M/SLAMF1/CD46	4.97304596778433
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	16/842	69/9376	2.58211986643258	FCER1G/SYK/LYN/LCP2/VAV3/INPP5D/SOS1/VAV1/ALOX5AP/RAC2/GRB2/NRAS/PRKCA/ALOX5/TNF/RAC1	4.14309066297719
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	31/842	181/9376	1.90716657261716	CD14/FCGR2A/FCER1G/FCGR2B/FCGR3A/CR1/MRC1/SYK/CLEC7A/FCGR1A/CTSS/ITGB2/CR1L/TLR1/CORO1A/CD209/CALM1/TLR2/ITGAM/CD74/IL10RA/LSP1/CASP10/ATP6V0C/CLEC4M/TLR6/TNF/CALM3/TLR4/IL10RB/ARHGEF12	3.87093451382028
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	17/842	76/9376	2.49081135141893	PLCB1/ITPR2/GNAI2/ATP1B1/PRKCB/EZR/KCNQ1/CHRM3/GNAS/ADCY4/CALM1/GNAQ/HRH2/PLCB2/PRKCA/CALM3/ATP1B3	4.09876838281196
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	19/842	91/9376	2.32497194017384	FCGR2B/SYK/LYN/PRKCB/VAV3/INPP5D/RASGRP3/SOS1/PIK3AP1/VAV1/LILRB5/RAC2/GRB2/PTPN6/NRAS/BLNK/BANK1/GSK3B/RAC1	3.98934676326374
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	33/842	200/9376	1.83733966745843	FCGR2A/TNFSF10/CXCL8/EZR/ARPC3/ARPC1B/CYTH4/TUBA1B/NCKAP1L/WIPF1/MYO5A/HCLS1/CDC42/MYO10/NLRP3/MYO1F/TJP1/PTPN6/NCK2/LPAR5/ACTR2/ARPC2/CASP1/PYCARD/CLDN11/TNF/TLR4/OCLN/ARHGEF12/RAC1/CYTH1/TMBIM6/TNFRSF10A	3.75971846806923
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	39/842	250/9376	1.73712114014252	DAB2/FOLR2/WWP1/PSD3/SNX2/ARAP2/ARPC3/RAB11FIP1/SH3KBP1/ARPC1B/CYTH4/SNX6/MVB12B/CLTC/FGFR3/WIPF1/NEDD4L/CDC42/CLTA/BIN1/ARRB2/ACTR2/ARPC2/ARAP1/GRK3/CHMP5/GIT2/CXCR4/PLD1/SNX4/EPS15/AP2S1/CAPZA2/IL2RB/IQSEC1/FGFR2/ACAP2/CYTH1/CAPZA1	3.71051339264015
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	28/842	160/9376	1.94869358669834	PECAM1/CADM1/PTPRD/CDH5/PTPRC/CD34/JAM2/CADM3/ITGA9/CD28/CD86/ICAM2/ITGA6/NTNG1/ITGB2/SIGLEC1/ITGA4/ITGAM/CD4/VCAM1/NCAM2/CLDN11/CDH1/OCLN/F11R/ITGAL/ICOSLG/JAM3	3.80171965104163
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	65/842	480/9376	1.50791765637371	MT-CO2/COX4I2/PLCB1/MT-ATP6/WNT2/MT-CYB/MT-ND1/MT-ND2/MT-CO3/CYBB/MT-CO1/ITPR2/MT-ND3/MT-ND5/LRP6/MT-ND4/PRKCB/UBA52/DNAH8/ATP5F1E/CTNNB1/UBB/NDUFA4L2/TUBA1B/WNT3A/UQCR10/NDUFC2/CHRM3/FZD1/MAPT/RYR1/CALM1/RPS27A/TANK/COX6C/GNAQ/MT-ND6/WNT2B/SNCA/ATP5PF/UQCR11/UQCRB/NDUFA1/COX4I1/NRAS/COX8A/GPX7/PLCB2/PSMA4/PRKCA/TNF/CACNA1D/TNFRSF1B/CALM3/GRIN2C/NDUFB3/ATP5MC3/GPR37/ATP5MC2/GSK3B/NDUFA13/RAC1/DNAH2/GRIA4/FZD2	3.58824349669077
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	33/842	201/9376	1.82819867408799	CD14/IGF1/FLI1/MEF2C/DUSP6/CXCL8/MAF/CSF1R/BMP2K/FLT1/CD86/FCGR1A/ID2/PROM1/SPI1/HHEX/LYL1/HPGD/PPARG/SPINT1/LMO2/ERG/ITGAM/ATM/MET/TSPAN7/CCND2/ETV5/CEBPA/BCL2A1/HDAC2/IL2RB/RUNX1T1	3.72816296407138
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	29/842	170/9376	1.89956685762191	CCND1/JAM2/CGNL1/EZR/GATA4/ARPC3/ARPC1B/AFDN/MAP3K1/TUBA1B/MAGI1/HCLS1/NEDD4L/CDC42/MYL12A/PCNA/MYL12B/WAS/TJP1/ACTR2/ARPC2/CLDN11/RAPGEF2/CACNA1D/OCLN/EPB41L4B/F11R/RAC1/JAM3	3.71781509689392
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	20/842	101/9376	2.20502810376049	PLCB1/WNT2/GNAI2/LEF1/PRKCB/CTNNB1/WNT3A/FZD1/GNAS/ADCY4/CALM1/GNAQ/WNT2B/NRAS/PLCB2/PRKCA/CALM3/GSK3B/KIT/FZD2	3.8244260534834
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	13/842	53/9376	2.7313225473939	PLCB1/KL/ATP1B1/PRKCB/CLTC/GNAS/CLTA/GNAQ/ATP2B1/PLCB2/PRKCA/AP2S1/ATP1B3	3.97011824941197
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	18/842	88/9376	2.27769380263442	F13A1/C1QA/C1QC/C1QB/CR1/F5/C3AR1/VSIG4/ITGB2/CR1L/C4BPB/CFD/ITGAM/VTN/C2/A2M/CFI/CD46	3.78244294418776
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	34/842	214/9376	1.76917441783027	GNGT1/GNG11/B2M/GNG2/ITPR2/GNAI2/AP1S2/PRKCB/GNG10/AP1B1/TRIM5/CALR/BST2/CALM1/TLR2/GNG5/CD4/GNAQ/ATM/RAC2/PAK4/NRAS/CDK1/LIMK2/CXCR4/CUL5/PRKCA/TNF/TNFRSF1B/CALM3/TLR4/CCNB2/RBX1/RAC1	3.57521315084472
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	20/842	103/9376	2.16221202407583	CD14/PLCB1/LAMA2/LAMC3/CXCL8/GNA14/PRKCB/ITGB2/GNAS/TLR2/ITGAM/GNAQ/SERPINB6/COL4A5/SERPINB9/GNA15/PLCB2/PRKCA/TNF/TLR4	3.72528249279321
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	40/842	268/9376	1.66199879462545	MT-CO2/COX4I2/MT-ATP6/MT-CYB/MT-ND1/MT-ND2/MT-CO3/MT-CO1/ITPR2/MT-ND3/MT-ND5/MT-ND4/GNAI2/UBA52/ATP5F1E/UBB/NDUFA4L2/TUBA1B/UQCR10/NDUFC2/MAPT/GNAS/CALM1/RPS27A/COX6C/MT-ND6/SNCA/ATP5PF/UQCR11/UQCRB/NDUFA1/COX4I1/COX8A/PSMA4/CALM3/NDUFB3/ATP5MC3/GPR37/ATP5MC2/NDUFA13	3.45365100388985
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	19/842	99/9376	2.13709541975575	C1QA/FCGR2A/C1QC/FCGR2B/FCGR3A/C1QB/KRT18/C3AR1/FCGR1A/ITGB2/KRT23/CFD/ITGAM/PTAFR/C2/FPR1/CFI/KRT19/ITGAL	3.57253172294379
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	31/842	195/9376	1.77024179304464	PLCB1/FCGR2A/CYBA/CYBB/FCGR3A/CR1/HDAC9/SYK/PRKCB/NCF4/CLEC7A/FCGR1A/ITGB2/CR1L/CLCN5/ATG7/TLR2/ITGAM/TLR7/RAC2/HDAC8/NCF2/FPR1/CASP1/PLCB2/PRKCA/TLR4/HDAC2/ITGAL/HMGB1/RAC1	3.41400974363121
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	19/842	100/9376	2.11572446555819	CXCL14/CCL3/CCL4/CCL4L2/ACKR3/CCL3L1/TNFSF10/CXCL8/CSF1R/CCR1/IL6ST/IL10RA/CX3CR1/CXCR4/TNF/TNFRSF1B/IL10RB/IL2RB/TNFRSF10A	3.52323775390135
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	18/842	93/9376	2.15523714657881	PLCB1/ITPR2/PRKCB/CGA/SOS1/MAP3K1/GNAS/CDC42/ADCY4/CALM1/GNAQ/GRB2/NRAS/PLD1/PLCB2/PRKCA/CACNA1D/CALM3	3.5166877523136
Organismal Systems	Digestive system	hsa04970	Salivary secretion	18/842	93/9376	2.15523714657881	PLCB1/ITPR2/ADRB1/GUCY1A2/ATP1B1/PRKCB/LYZ/CHRM3/GNAS/ADCY4/CALM1/GNAQ/ATP2B1/PLCB2/PRKCA/CALM3/ATP1B3/ADRB2	3.5166877523136
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	26/842	157/9376	1.84407764346339	AREG/WNT2/BMP5/CCND1/LEF1/ID1/ID2/CTNNB1/WNT3A/ITGB2/WWC1/BMP6/FZD1/BMP4/PPP1CA/WNT2B/BMP7/BIRC5/RASSF6/CCND2/YWHAE/BMPR2/YWHAB/CDH1/GSK3B/FZD2	3.3500838787247
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	16/842	80/9376	2.2270783847981	HGF/IGF1/KDR/PRKCB/PDGFC/SOS1/FGFR3/GRB2/MET/NRAS/RPS6/PRKCA/GAS6/FGFR2/GSK3B/EIF4EBP1	3.46206013090251
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	19/842	103/9376	2.05410142287203	C1QA/PLCB1/CCL3/C1QC/C1QB/CCL3L1/CXCL8/GNAI2/GNA14/CALR/GNAS/TLR2/GNAQ/GNA15/PLCB2/TLR6/TNF/TLR4/ACE	3.37875146264827
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	52/842	388/9376	1.4923721135245	MT-CO2/COX4I2/PLCB1/MT-ATP6/WNT2/MT-CYB/MT-ND1/MT-ND2/MT-CO3/CYBB/MT-CO1/ITPR2/MT-ND3/MT-ND5/LRP6/MT-ND4/ATP5F1E/CTNNB1/NDUFA4L2/TUBA1B/WNT3A/UQCR10/NDUFC2/CHRM3/FZD1/MAPT/CALM1/COX6C/GNAQ/MT-ND6/WNT2B/SNCA/ATP5PF/UQCR11/UQCRB/NDUFA1/COX4I1/NRAS/COX8A/PLCB2/PSMA4/TNF/CACNA1D/CALM3/GRIN2C/APH1A/NDUFB3/ATP5MC3/ATP5MC2/GSK3B/NDUFA13/FZD2	3.11130898695246
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	14/842	67/9376	2.32679831247563	PLCB1/ITPR2/PRKCB/RPS6KA2/CALM1/GNAQ/PPP1CA/NRAS/PLCB2/PRKCA/CALM3/GRIN2C/RPS6KA1/RAPGEF3	3.42338829452118
Organismal Systems	Nervous system	hsa04730	Long-term depression	13/842	60/9376	2.41266825019794	PLCB1/IGF1/ITPR2/GUCY1A2/GNAI2/LYN/PRKCB/RYR1/GNAS/GNAQ/NRAS/PLCB2/PRKCA	3.44799346812594
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	19/842	105/9376	2.014975681484	CD14/CCL4/CCL4L2/CXCL8/SYK/LYN/EDA/PRKCB/LY96/TNFSF13B/TNFRSF11A/ATM/VCAM1/LTB/TNF/PARP1/BLNK/TLR4/BCL2A1	3.28512848898995
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	25/842	154/9376	1.8076934941543	PLCB1/AGTR1/ADRB1/GNAI2/ATP1B1/KCNQ1/TPM3/CREM/GNAS/ADCY4/CALM1/CACNB4/GNAQ/PPP1CA/PIK3R5/ATP2B1/PIK3CG/PLCB2/PRKCA/CACNA1D/CALM3/ATP1B3/ADRB2/RAPGEF3/RPS6KA5	3.17438611531706
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	25/842	154/9376	1.8076934941543	PLCB1/ITPR2/CCND1/GUCY1A2/MEF2C/GNAI2/PRKCB/TRPM2/RYR1/GNAS/ADCY4/CALM1/CACNB4/GNAQ/PPP1CA/NPR1/PIK3R5/NRAS/PIK3CG/KCNJ5/PLCB2/PRKCA/MAP2K5/CACNA1D/CALM3	3.17438611531706
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	30/842	196/9376	1.70439672305977	GNGT1/GNG11/GNG2/CDK6/ITPR2/CCND1/CXCL8/LEF1/SYK/LYN/UBA52/CD86/PREX1/CTNNB1/CCR1/UBB/GNG10/HCK/CD200R1/CALM1/RPS27A/RB1/GNG5/IL6ST/PIK3R5/NRAS/PIK3CG/CALM3/GSK3B/RAC1	3.13032469001852
Human Diseases	Substance dependence	hsa05032	Morphine addiction	17/842	91/9376	2.08023805173449	GNGT1/GNG11/GNG2/PDE4D/GNAI2/PRKCB/GNG10/PDE3B/GNAS/ADCY4/PDE4B/GNG5/ARRB2/GRK3/KCNJ5/GABRA3/PRKCA	3.25247957679458
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	36/842	250/9376	1.60349643705463	LGMN/VAMP8/NPC2/AP1S2/ASAH1/LAPTM5/CTSS/CD68/SUMF1/CLTC/ATP6V1G1/AP1B1/CTSC/MANBA/GPR155/FUCA1/CLTA/SLC38A9/DMXL2/TLR7/HYAL2/MCOLN2/SLC15A3/ATP6V0C/ACP2/CTSZ/WDR7/AP3M2/NAGA/ARSB/CTSL/AP2S1/CTSO/ATP6V1C2/LAMTOR1/HYAL4	3.03787463166349
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	18/842	100/9376	2.00437054631829	CD14/CD36/CR1/CD34/CSF1R/CD24/FCGR1A/ITGA6/CR1L/ITGA4/CSF3R/ITGAM/CD4/ITGA2/CD33/CSF2RA/TNF/KIT	3.17160404466415
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	25/842	157/9376	1.77315158025326	C1QA/CD36/PECAM1/C1QC/SLC2A1/C1QB/ELMO1/CD24/ATP8A1/STAB1/PPARG/CALR/S1PR1/GULP1/SCARF1/PTPN6/DUSP4/PTGER4/VPS8/CASP1/CX3CR1/ALOX5/GAS6/SIRPA/RAC1	3.06858339973236
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	24/842	149/9376	1.79362017567632	PLCB1/AGTR1/FCER1G/LPAR6/CXCL8/SYK/PDGFC/SOS1/CYTH4/GNAS/ADCY4/GRB2/PIK3R5/NRAS/LPAR5/PIK3CG/PLD1/PLCB2/PRKCA/GRM7/RALA/KIT/RAPGEF3/CYTH1	3.06719182955846
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	22/842	133/9376	1.84194452878038	TYROBP/FCER1G/HCST/FCGR3A/TNFSF10/SYK/PRKCB/LCP2/VAV3/ICAM2/SOS1/ITGB2/VAV1/RAC2/GRB2/PTPN6/NRAS/PRKCA/TNF/ITGAL/RAC1/TNFRSF10A	3.07162495824095
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	25/842	158/9376	1.76192910189723	WNT2/IGF1/LRP6/PRKCB/SOS1/WNT3A/ATP6V1G1/RPS6KA2/FZD1/SKP2/SLC38A9/GRB2/WNT2B/FNIP2/NRAS/PRR5/RPS6/PRKCA/TNF/RPS6KA1/GSK3B/ATP6V1C2/EIF4EBP1/LAMTOR1/FZD2	3.03382215170687
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	23/842	142/9376	1.80361981867452	FCGR2A/TYROBP/CYBA/FCGR2B/FCGR3A/ITPR2/CSF1R/SYK/LCP2/NCF4/FCGR1A/SPI1/LILRB5/PPARG/TNFRSF11A/GRB2/TEC1/NCF2/CALCR/TNF/BLNK/SIRPA/RAC1	3.03085556378876
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	36/842	254/9376	1.57824452466007	PLCB1/HGF/AGTR1/ITPR2/ADRB1/KDR/GNA14/PRKCB/FLT1/PDGFC/CYSLTR1/FGFR3/CHRM3/RYR1/GNAS/ADCY4/CALM1/GNAQ/MCOLN2/PTAFR/MET/STIM2/ATP2B1/TBXA2R/HRH2/CXCR4/ORAI1/GNA15/PLCB2/PRKCA/CACNA1D/CALM3/GRIN2C/FGFR2/ADRB2/PHKB	2.93459868243048
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	42/842	308/9376	1.51846253508961	MT-CO2/COX4I2/PLCB1/MT-ATP6/MT-CYB/MT-ND1/MT-ND2/MT-CO3/MT-CO1/MT-ND3/MT-ND5/MT-ND4/DNAH8/ATP5F1E/NDUFA4L2/TUBA1B/CLTC/UQCR10/NDUFC2/PPARG/CLTA/COX6C/GNAQ/MT-ND6/ATP5PF/UQCR11/UQCRB/NDUFA1/COX4I1/COX8A/GPX7/PLCB2/PSMA4/SLC1A3/AP2S1/HDAC2/NDUFB3/ATP5MC3/ATP5MC2/NDUFA13/DNAH2/GRIA4	2.90604507511792
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	19/842	110/9376	1.92338587778018	BMP5/PITX2/ID1/DCN/SMAD6/ID2/SMAD9/BAMBI/IGSF1/BMP6/BMP4/SMAD5/NRROS/ID3/BMP7/BMPR2/TNF/HDAC2/RBX1	3.05984049206512
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	16/842	87/9376	2.04788816992929	MT-CO2/COX4I2/MT-CYB/MT-CO3/MT-CO1/ATP1B1/TPM3/UQCR10/CACNB4/COX6C/UQCR11/UQCRB/COX4I1/COX8A/CACNA1D/ATP1B3	3.0842917130762
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	13/842	65/9376	2.2270783847981	SPP1/PLCB1/ITPR2/PRKCB/CGA/KISS1/GNAQ/NRAS/ARRB2/KCNJ5/PLCB2/PRKCA/CACNA1D	3.11814412980621
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	35/842	248/9376	1.57152708604705	CD14/ELMO1/PTPRC/TNFSF10/CXCL8/S100A10/LEF1/ARPC3/CTNNB1/LY96/ARPC1B/CYTH4/TUBA1B/NCKAP1L/CDC42/NLRP3/MYL12A/MYL12B/PFN1/TLR2/PIK3C2B/ACTR2/ARPC2/PIK3CG/SNX18/CASP1/PYCARD/TLR6/TNF/RALA/TLR4/KPNA3/RAC1/CYTH1/TNFRSF10A	2.86510278543477
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	24/842	155/9376	1.72418971726304	PLCB1/WNT2/AGTR1/CDK6/ITPR2/CCND1/SCARB1/GNAI2/LEF1/CTNNB1/WNT3A/FZD1/GNAS/ADCY4/RB1/KCNK3/GNAQ/WNT2B/AHR/ORAI1/PLCB2/CACNA1D/GSK3B/FZD2	2.85558148065432
NA	NA	hsa04082	Neuroactive ligand signaling	29/842	199/9376	1.62274555676243	PLCB1/GNGT1/GNG11/GNG2/ADRB1/GNAI2/PRKCB/P2RY1/GNG10/TAC3/CHRM3/GNAS/ADCY4/P2RY14/GNG5/GNAQ/P2RY13/SLC6A4/GRIK4/GABRA3/HRH2/PLCB2/PRKCA/GRM7/SLC1A3/GRIN2C/ADRB2/OGFRL1/GRIA4	2.78902350646868
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	19/842	115/9376	1.83976040483321	PLCB1/GNGT1/GNG11/GNG2/ITPR2/GNAI2/PRKCB/KCNQ1/GNG10/CHRM3/ADCY4/GNG5/GNAQ/PIK3R5/NRAS/PIK3CG/PLCB2/PRKCA/CACNA1D	2.84603827446824
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	19/842	115/9376	1.83976040483321	PLCB1/GNGT1/GNG11/GNG2/ITPR2/GNAI2/PRKCB/GNG10/GNAS/GNG5/GNAQ/NRAS/SLC6A4/KCNJ5/PLCB2/PRKCA/ALOX5/CACNA1D/RAPGEF3	2.84603827446824
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	19/842	115/9376	1.83976040483321	PLCB1/ITPR2/KL/LRP6/MEF2C/PDE4D/GNAI2/PRKCB/GNAS/ADCY4/PDE4B/GNAQ/MAFB/ARRB2/NR4A2/PLD1/PLCB2/PRKCA/CYP24A1	2.84603827446824
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	24/842	157/9376	1.70222551704313	MT-CO2/COX4I2/MT-CYB/MT-CO3/MT-CO1/CXCL8/NDUFA4L2/UQCR10/NDUFC2/PPARG/CDC42/COX6C/UQCR11/UQCRB/NDUFA1/COX4I1/MAP3K11/COX8A/CEBPA/TNF/NDUFB3/GSK3B/NDUFA13/RAC1	2.78708292074003
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	21/842	133/9376	1.75821977747218	PLCB1/GNGT1/GNG11/GNG2/ITPR2/GNAI2/PRKCB/GNG10/GNAS/CALM1/GNG5/GNAQ/PPP1CA/ARRB2/KCNJ5/PLCB2/PRKCA/CACNA1D/CALM3/GSK3B/GRIA4	2.76617605163268
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	12/842	62/9376	2.15523714657881	RBPJ/MAML3/MFNG/HEY1/DLL4/TLE4/JAG2/HDAC2/APH1A/DTX4/NOTCH4/CTBP1	2.86658113073151
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	22/842	144/9376	1.70124043283188	WNT2/IGF1/ID1/DUSP9/ID2/CTNNB1/WNT3A/SMAD9/FGFR3/FZD1/BMP4/SMAD5/KLF4/IL6ST/GRB2/ID3/WNT2B/NRAS/BMPR2/FGFR2/GSK3B/FZD2	2.6635794892068
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	11/842	56/9376	2.18730912792671	CD14/CR1/CXCL8/ITGB2/CR1L/TLR2/ITGAM/CASP1/PYCARD/TNF/TLR4	2.79907946835141
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	39/842	298/9376	1.45731639273701	CXCL14/CCL3/BMP5/CCL4/CCL4L2/CSH1/ACKR3/CCL3L1/TNFSF10/CXCL8/IL33/IL12RB2/CSF1R/EDA/CCR1/TNFSF13B/BMP6/BMP4/TNFRSF11A/GDF15/CSF3R/CD4/IL6ST/IL10RA/TNFRSF19/BMP7/TNFRSF25/CX3CR1/CSF2RA/CXCR4/BMPR2/LTB/ACVRL1/TNF/TNFRSF1B/IL10RB/IL2RB/CSF2RB/TNFRSF10A	2.51996887495889
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	24/842	166/9376	1.60993618178176	PLCB1/AGTR1/ITPR2/ADRB1/GUCY1A2/MEF2C/GNAI2/ATP1B1/GATA4/PDE3B/ADCY4/CALM1/GNAQ/PPP1CA/NPR1/PIK3R5/ATP2B1/PIK3CG/KCNMB4/PLCB2/CACNA1D/CALM3/ATP1B3/ADRB2	2.49042799911965
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/842	37/9376	2.40765230788984	CCND1/LEF1/CTNNB1/NCOA4/TPM3/PPARG/NRAS/CDH1	2.69470628767234
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	13/842	75/9376	1.93013460015835	PLCB1/ITPR2/ATP1B1/PRKCB/CGA/GNAS/ADCY4/LRP2/GNAQ/GPX7/PLCB2/PRKCA/ATP1B3	2.54025300759485
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/842	52/9376	2.14142152384433	HSD17B2/IGF1/SCARB1/CGA/HSD17B1/CYP19A1/BMP6/GNAS/ADCY4/ALOX5	2.59245938908426
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	20/842	134/9376	1.66199879462545	PLCB1/AGTR1/ITPR2/GUCY1A2/RAMP2/PRKCB/PRKCH/PLA2G2A/GNAS/ADCY4/CALM1/GNAQ/PPP1CA/NPR1/KCNMB4/PLCB2/PRKCA/CACNA1D/CALM3/ARHGEF12	2.42433136615318
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	17/842	109/9376	1.73671250190678	SPP1/CD14/CCL3/CCL4/CCL4L2/CCL3L1/CXCL8/CD86/LY96/TLR1/TLR2/TLR7/TLR6/TNF/TLR4/IRF5/RAC1	2.43000446718051
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	16/842	102/9376	1.74672814493969	PLCB1/ITPR2/ATP1B1/PRKCB/SLC4A4/KCNQ1/PLA2G2A/CHRM3/GNAS/ADCY4/GNAQ/ATP2B1/PLCB2/PRKCA/ATP1B3/RAC1	2.38174041111835
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	18/842	120/9376	1.67030878859857	SOS1/MAP3K1/RPS6KA2/CDC42/CALM1/ARHGDIG/RAPGEF1/BEX3/GRB2/NRAS/SH2B3/YWHAE/MAP2K5/CALM3/RPS6KA1/GSK3B/RAC1/RPS6KA5	2.32123563074634
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	13/842	78/9376	1.85589865399842	ELMO1/ARPC3/CTNNB1/ARPC1B/CLTC/HCLS1/CDC42/CLTA/MET/ACTR2/ARPC2/CDH1/RAC1	2.38418657668895
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/842	70/9376	1.90892432982694	HGF/SLC2A1/SOS1/EPAS1/CDC42/RAPGEF1/GRB2/MET/PAK4/NRAS/RBX1/RAC1	2.39751089409393
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	14/842	87/9376	1.79190214868813	AREG/CCND1/LEF1/CTNNB1/SOS1/PMAIP1/RAC2/GRB2/BIRC5/NRAS/RALA/GSK3B/RAC1/MSH2	2.33083768369181
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	41/842	333/9376	1.37102423088171	SPP1/WNT2/LAMA2/RBPJ/CDK6/CCND1/LAMC3/ITGA9/CTNNB1/SOS1/ITGA6/MAML3/WNT3A/MAGI1/ATP6V1G1/ITGA4/FZD1/GNAS/CDC42/MFNG/HEY1/RB1/ATM/GRB2/WNT2B/COL4A5/ITGA2/NRAS/COL6A6/ATP6V0C/VTN/PTGER4/CCND2/ITGB4/TNF/HDAC2/GSK3B/ATP6V1C2/EIF4EBP1/NOTCH4/FZD2	2.16537685033902
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/842	71/9376	1.88203807166037	JAM2/CXCL8/LYN/ATP6V1G1/CDC42/MET/TJP1/ATP6V0C/F11R/ATP6V1C2/RAC1/JAM3	2.34327727850705
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	21/842	148/9376	1.58002182705271	WNT2/IGF1/CDK6/CCND1/LRP6/LEF1/CTNNB1/SOS1/WNT3A/FZD1/HEY1/RB1/DLL4/GRB2/WNT2B/JAG2/NRAS/GSK3B/NOTCH4/KIT/FZD2	2.23401850643089
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/842	41/9376	2.17275939980302	CCND1/CXCL8/FGFR3/RB1/MMP1/NRAS/CDH1/RPS6KA5	2.36379088948235
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	12/842	73/9376	1.83047538476556	HGF/CDK6/CCND1/PRKCB/SOS1/RARB/RB1/GRB2/MET/NRAS/FHIT/PRKCA	2.2373918346316
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	20/842	142/9376	1.56836505971697	PECAM1/CYBA/CDH5/KDR/MGST2/MEF2C/CTNNB1/BMP4/KLF2/CALM1/SUMO2/RAC2/NCF2/VCAM1/BMPR2/TNF/MAP2K5/CALM3/CTSL/RAC1	2.14359123988208
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	11/842	65/9376	1.88445094098301	PLCB1/AGTR1/ITPR2/SCARB1/GNAS/ADCY4/KCNK3/GNAQ/ORAI1/PLCB2/CACNA1D	2.24748927525238
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	18/842	125/9376	1.60349643705463	PLCB1/FCER1G/GNAI2/PRKCB/ASAH1/S1PR1/SPTLC2/GNAQ/RAC2/SGMS1/NRAS/DEGS1/PLD1/PLCB2/PRKCA/SPTLC3/TNF/RAC1	2.13353976245411
NA	NA	hsa04081	Hormone signaling	28/842	219/9376	1.42370307703988	PLCB1/GNGT1/AGTR1/GNG11/GNG2/IGF1/CSH1/ADRB1/SLC40A1/SLC16A10/RAMP2/GNAI2/GNA14/CGA/IGF2/GNG10/SMAD9/GNAS/ADCY4/SMAD5/GNG5/GNAQ/NPR1/CALCR/GNA15/PLCB2/ADRB2/RAPGEF3	1.99284000583567
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/842	59/9376	1.88735456338822	ADRB1/GNAI2/CGA/PDE3B/GNAS/ADCY4/PLAAT3/NPR1/FABP4/ADRB2	2.14758573145346
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	18/842	130/9376	1.54182349716792	PLCB1/GNGT1/GNG11/GNG2/GNAI2/SOS1/GNG10/GNAS/ADCY4/GNG5/GRB2/MMP1/COL4A5/NRAS/ARRB2/GNA15/PLCB2/PRKCA	1.95397017913857
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	13/842	86/9376	1.68325691874275	PLCB1/SLC2A1/ATP1B1/PRKCB/CHRM3/GNAS/ADCY4/GNAQ/KCNMB4/PLCB2/PRKCA/CACNA1D/ATP1B3	1.99935895141464
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/842	86/9376	1.68325691874275	LAMA2/LEF1/GJA1/ITGA9/CTNNB1/ITGA6/DSP/ITGA4/CACNB4/DSC2/ITGA2/ITGB4/CACNA1D	1.99935895141464
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	21/842	158/9376	1.48002044559367	CDK6/CCND1/CDKN1C/SKP2/CDC14A/PCNA/RB1/ATM/HDAC8/CDC25B/CDK1/CCND2/YWHAE/YWHAB/BUB1/HDAC2/CCNB2/MAD2L1/KNL1/GSK3B/RBX1	1.91132830795944
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	17/842	122/9376	1.55165297301507	PLCB1/SLC2A1/CCND1/SLC16A10/ATP1B1/PRKCB/GATA4/CTNNB1/TBC1D4/BMP4/NRAS/PLCB2/PRKCA/HDAC2/ATP1B3/GSK3B/NOTCH4	1.92640011498864
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	17/842	122/9376	1.55165297301507	PLCB1/IGF1/CSH1/ITPR2/GNAI2/PRKCB/SOS1/MAP3K1/GNAS/ADCY4/GNAQ/GRB2/NRAS/PLCB2/PRKCA/CACNA1D/GSK3B	1.92640011498864
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	15/842	105/9376	1.59077027485579	FCER1G/ITPR2/SYK/CLEC7A/CD209/CALM1/NLRP3/LSP1/NRAS/CLEC4M/CASP1/PYCARD/TNF/CALM3/ARHGEF12	1.91212094612906
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	28/842	226/9376	1.37960607907847	ADRB1/PDE4D/GNAI2/ATP1B1/CGA/VAV3/AFDN/VAV1/PDE3B/GNAS/ADCY4/CALM1/PDE4B/RAC2/PPP1CA/NPR1/ATP2B1/ORAI1/PLD1/CACNA1D/CALM3/GRIN2C/GLI3/ATP1B3/ADRB2/RAC1/RAPGEF3/GRIA4	1.8144382636939
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/842	38/9376	2.05125640705088	IGF1/ATP1B1/PRKCB/NEDD4L/PRKCA/ATP1B3/NR3C2	2.03957126131955
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	15/842	106/9376	1.57576300811186	FOLR2/IGF1/CCND1/LEF1/PDGFC/CTNNB1/SOS1/SPINT1/ERG/RB1/GRB2/NRAS/ETV5/FGFR2/GSK3B	1.87250156322067
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/842	63/9376	1.76752252761754	WNT2/LEF1/CTNNB1/WNT3A/FZD1/BMP4/WNT2B/GLI3/GSK3B/FZD2	1.91991485671328
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	13/842	89/9376	1.62651792148176	SPP1/LAMA2/CD36/LAMC3/ITGA9/FREM1/ITGA6/ITGA4/COL4A5/ITGA2/COL6A6/VTN/ITGB4	1.86533201299748
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/842	89/9376	1.62651792148176	GNGT1/GNG11/GNG2/GNAI2/PRKCB/GNG10/ADCY4/GNG5/GABRA3/PRKCA/CACNA1D/GABARAPL2/SLC12A5	1.86533201299748
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	14/842	99/9376	1.57470188824108	PLCB1/IGF1/ITPR2/PRKCB/PRKCH/GNAS/ADCY4/CALM1/GNAQ/PPP1CA/PTGER4/PLCB2/PRKCA/CALM3	1.80560108791747
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/842	99/9376	1.57470188824108	PRKCB/PDGFC/SOS1/LYPLA1/WAS/RAC2/GRB2/NRAS/SLC44A4/PLD1/PRKCA/EIF4EBP1/SLC44A5/RAC1	1.80560108791747
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	18/842	137/9376	1.46304419439291	ITPR2/TNFSF10/TUBA1B/PMAIP1/CTSS/CTSC/ATM/BIRC5/NRAS/CASP10/CTSZ/TNF/PARP1/CTSL/BCL2A1/CTSO/CSF2RB/TNFRSF10A	1.7148873949595
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	14/842	101/9376	1.54351967263235	PLCB1/AGTR1/CYBB/CCND1/CXCL8/PRKCB/CDC42/COL4A5/NRAS/VCAM1/PLCB2/PRKCA/TNF/RAC1	1.72498117687806
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	30/842	253/9376	1.32040220442575	CD14/PLCB1/ELMO1/ITPR2/CXCL8/UBA52/ARPC3/UBB/ARPC1B/CYTH4/HCLS1/CDC42/RPS27A/NLRP3/MYL12A/MYL12B/PFN1/ATM/ACTR2/ARPC2/CASP1/PYCARD/PLCB2/TNF/TLR4/GSK3B/RBX1/RAC1/RPS6KA5/CYTH1	1.6227524866142
Human Diseases	Cancer: specific types	hsa05214	Glioma	11/842	76/9376	1.61170146268284	IGF1/CDK6/CCND1/PRKCB/SOS1/CALM1/RB1/GRB2/NRAS/PRKCA/CALM3	1.681783957828
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	19/842	150/9376	1.4104829770388	WNT2/HGF/CCND1/LRP6/LEF1/CTNNB1/SOS1/WNT3A/FZD1/RARB/RB1/GRB2/MET/WNT2B/NRAS/CDH1/FGFR2/GSK3B/FZD2	1.59184002547185
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	16/842	122/9376	1.46037926872007	PTPRC/LCP2/VAV3/CD28/SOS1/VAV1/CDC42/CD4/GRB2/PAK4/PTPN6/NCK2/NRAS/TEC1/TNF/GSK3B	1.60766771790151
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	21/842	170/9376	1.37554841414	WNT2/HGF/CDK6/CCND1/MGST2/LRP6/LEF1/PRKCB/IGF2/CTNNB1/SOS1/WNT3A/FZD1/RB1/GRB2/MET/WNT2B/NRAS/PRKCA/GSK3B/FZD2	1.55210204986355
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	8/842	51/9376	1.74672814493969	ENPP2/LPCAT2/PLA2G2A/PLAAT3/PLD1/CEPT1/PLD4/AGPS	1.67953304530143
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/842	19/9376	2.34429303662958	HPSE2/HYAL2/ARSB/HYAL4	1.84233159227471
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	41/842	368/9376	1.24062790457503	MT-CO2/COX4I2/MT-ATP6/MT-CYB/MT-ND1/MT-ND2/MT-CO3/MT-CO1/MT-ND3/MT-ND5/MT-ND4/DNAH8/ATP5F1E/NDUFA4L2/TUBA1B/UQCR10/NDUFC2/TANK/PFN1/COX6C/MT-ND6/ATP5PF/UQCR11/HNRNPA1/UQCRB/NDUFA1/COX4I1/COX8A/HNRNPA2B1/GPX7/CASP1/PSMA4/TNF/TNFRSF1B/GRIN2C/NDUFB3/ATP5MC3/ATP5MC2/NDUFA13/RAC1/DNAH2	1.47918016468028
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	14/842	105/9376	1.48471892319873	LAMA2/IGF1/ADRB1/ITGA9/ITGA6/TPM3/ITGA4/GNAS/ADCY4/CACNB4/ITGA2/ITGB4/TNF/CACNA1D	1.56886906041384
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	10/842	69/9376	1.61382491652036	PRKCB/GNAS/CALM1/PPP1CA/PRKCA/CACNA1D/CALM3/HDAC2/GRIN2C/GRIA4	1.60742073612451
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/842	52/9376	1.71313721907546	LIPG/CD36/PLTP/SCARB1/NPC2/MYLIP/LRP2/APOC1	1.61971650321688
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/842	70/9376	1.59077027485579	LAMA2/CCND1/CD28/CD86/ITGB2/RAC2/EIF4G2/EIF4G3/ITGAL/RAC1	1.55830152565427
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	22/842	187/9376	1.31004610870476	PLCB1/CYBA/CYBB/ITPR2/CXCL8/CARD16/CARD18/GPSM3/PKN2/CARD8/TRPM2/NLRP3/TANK/CASP1/PYCARD/YWHAE/GBP4/PLCB2/TNF/GABARAPL2/TLR4/OAS3	1.34517357468446
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	25/842	217/9376	1.28287925391596	CCND1/ADRB1/MGST2/GNAI2/PRKCB/SOS1/RPS6KA2/PAQR7/GNAS/ADCY4/KLF4/RB1/DLL4/GRB2/BIRC5/NRAS/ARRB2/AHR/PAQR8/PRKCA/CACNA1D/RPS6KA1/ADRB2/EIF4EBP1/KPNA3	1.32425706926087
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	8/842	56/9376	1.59077027485579	CCND1/DISP1/LRP2/ARRB2/GRK3/CCND2/GLI3/GSK3B	1.39274002697908
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/842	22/9376	2.02461671345282	HNMT/CNDP2/ASPA/AOC1	1.5112609412163
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	10/842	75/9376	1.48471892319873	IGF1/CDK6/CCND1/PMAIP1/ATM/CDK1/CCND2/CCNG2/CCNB2/TNFRSF10A	1.32379625732027
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	16/842	133/9376	1.33959602093119	IGF1/CCND1/TNFSF10/SOS1/SKP2/KLF2/S1PR1/ATM/GRB2/NLK/NRAS/CCND2/CCNG2/GABARAPL2/CCNB2/PLK2	1.23893151859134
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/842	23/9376	1.93658989982443	ATP1B1/SLC4A4/CA4/ATP1B3	1.41254823093449
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	23/842	205/9376	1.24933665488674	RBPJ/CDK6/CCND1/HDAC9/SYK/LYN/PMAIP1/SKP2/SCIN/CDC42/RB1/IL6ST/GRB2/HDAC8/NRAS/HNRNPK/CDK1/CCND2/YWHAE/YWHAB/HDAC2/RASA2/RAC1	1.13375724976802
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/842	59/9376	1.50988365071058	CCND1/LEF1/CTNNB1/SOS1/GRB2/NRAS/CDH1/GSK3B	1.23402628233102
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	10/842	79/9376	1.40954328151778	SYT1/CLTC/ATP6V1G1/CLTA/SLC6A4/ATP6V0C/SLC1A3/AP2S1/ATP6V1C2/STX3	1.1481729225697
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/842	51/9376	1.52838712682223	KCNQ1/ATP6V1G1/GNAS/TJP1/ATP6V0C/PRKCA/ATP6V1C2	1.18844273678941
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/842	42/9376	1.59077027485579	FTL/CYBB/SLC40A1/NCOA4/ATG7/PCBP1	1.20524335822326
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	12/842	99/9376	1.34974447563521	LAMA2/IGF1/ITGA9/ITGA6/TPM3/ITGA4/CACNB4/ITGA2/ITGB4/TNF/CACNA1D/ACE	1.09882883390694
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/842	139/9376	1.2817717322579	PLCB1/ITPR2/GNAI2/KRT18/SOS1/KRT23/GNAS/ADCY4/CALM1/GNAQ/GRB2/NRAS/KCNJ5/PLCB2/CALM3/KRT19	1.0512468680349
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	13/842	110/9376	1.31600086374433	CYBB/IGF1/SLC2A1/PRKCB/FLT1/TEK/MKNK1/EPAS1/RPS6/PRKCA/TLR4/EIF4EBP1/RBX1	1.0471377802928
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/842	17/9376	1.96506916305715	CA8/CA4/CA1	1.25093153399506
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/842	17/9376	1.96506916305715	PCDH11X/CD209/CLEC4M	1.25093153399506
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/842	63/9376	1.41401802209403	PTGDS/HPGDS/LTC4S/PLA2G2A/HPGD/TBXAS1/PLAAT3/ALOX5	1.03564302409827
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	13/842	112/9376	1.29250084832033	LAMA2/LAMC3/GNAI2/ITGA6/LY96/TLR2/IL10RA/PIK3R5/PIK3CG/ALOX5/TNF/TLR4/IL10RB	0.978142733163299
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/842	73/9376	1.37285653857417	HGF/IGF1/CDK6/CCND1/PDGFC/RB1/MET/NRAS/CDH1	1.00451643745028
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/842	93/9376	1.31708936735371	LAMA2/CDK6/CCND1/LAMC3/ITGA6/SKP2/RARB/RB1/COL4A5/ITGA2/FHIT	0.965260074837463
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	7/842	56/9376	1.39192399049881	ST6GAL1/MAN1A1/MGAT4A/TUSC3/MGAT4C/RPN2/MGAT5	0.923960213188305
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	17/842	156/9376	1.21347219684512	CDK6/CCND1/SCARB1/CTNNB1/SOS1/RB1/GRB2/NRAS/YWHAE/CLDN11/YWHAB/PIAS1/TNF/OCLN/IFIT1/OAS3/GSK3B	0.844507523183129
Human Diseases	Infectious disease: viral	hsa05162	Measles	15/842	136/9376	1.22816822691072	FCGR2B/CDK6/CCND1/CD28/CD209/TLR2/TLR7/CLEC4M/CCND2/TLR4/SLAMF1/IL2RB/OAS3/GSK3B/CD46	0.84188738261253
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/842	28/9376	1.59077027485579	ATP6V1G1/ATP6V0C/SLC4A1/ATP6V1C2	0.983339905239034
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	10/842	86/9376	1.2948130144175	AREG/PRKCB/SOS1/GRB2/PAK4/NCK2/NRAS/PRKCA/GSK3B/EIF4EBP1	0.862687260384827
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	17/842	157/9376	1.20574307457222	CDK6/ITPR2/CCND1/CXCL8/GATA4/ZFP36L1/CALM1/RB1/ATM/PPP1CA/NRAS/CDK1/CCND2/CACNA1D/CALM3/CCNB2/EIF4EBP1	0.81657956779368
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	9/842	77/9376	1.3015393157911	CDK6/CCND1/SOS1/MECOM/RB1/GRB2/NRAS/HDAC2/CTBP1	0.834519613944632
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	15/842	138/9376	1.21036868739027	IGF1/ITPR2/RPS6KA2/ADCY4/CALM1/PPP1CA/CDK1/YWHAE/YWHAB/BUB1/CALM3/CCNB2/RPS6KA1/MAD2L1/RBX1	0.781982485587243
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/842	48/9376	1.39192399049881	PLCB1/ATP1B1/PRKCB/PLCB2/CACNA1D/ATP1B3	0.85505403949368
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/842	29/9376	1.53591612744697	WWC1/RASSF4/DCHS1/RASSF6	0.907872933974028
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	11/842	99/9376	1.23726576933228	IGF1/CCND1/SOS1/GNAS/ADCY4/RB1/DLL4/GRB2/JAG2/NRAS/NOTCH4	0.745442706901675
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/842	30/9376	1.48471892319873	FOLR2/TYMS/ABCG2/TNF	0.835224217711728
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	12/842	110/9376	1.21477002807169	IGF1/GNAI2/PDE3B/RPS6KA2/ADCY4/STK10/CDC25B/CDK1/BUB1/CCNB2/RPS6KA1/MAD2L1	0.711687328330752
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/842	50/9376	1.33624703087886	CD28/CD86/TNFSF13B/ITGA4/CXCR4/ICOSLG	0.748791868308336
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	7/842	60/9376	1.29912905779889	KDR/PRKCB/CDC42/RAC2/NRAS/PRKCA/RAC1	0.730104210434917
NA	NA	hsa04981	Folate transport and metabolism	4/842	31/9376	1.43682476438587	FOLR2/SLCO2B1/TYMS/ABCG2	0.765180352398807
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	8/842	71/9376	1.25469204777358	CCND1/CGA/SOS1/TNFRSF11A/GRB2/NRAS/CCND2/GSK3B	0.676630757491908
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/842	23/9376	1.45244242486833	FUT9/LARGE2/B4GAT1	0.682365619111698
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/842	23/9376	1.45244242486833	PCNA/RPA3/MSH2	0.682365619111698
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/842	23/9376	1.45244242486833	AGTR1/PRCP/ACE	0.682365619111698
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/842	33/9376	1.34974447563521	VAMP8/VAMP5/STX7/STX3	0.632164383146721
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	14/842	138/9376	1.12967744156425	SOS1/MKNK1/PDE3B/CALM1/RAPGEF1/GRB2/PPP1CA/NRAS/PYGL/RPS6/CALM3/GSK3B/EIF4EBP1/PHKB	0.482036986288192
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/842	44/9376	1.26538544590801	MAN1A1/MGAT4A/TUSC3/MGAT4C/RPN2	0.554219037481316
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	11/842	107/9376	1.14475991741958	PLCB1/SLC2A1/ITPR2/PDE3B/GNAS/CALM1/GNAQ/PYGL/PLCB2/CALM3/PHKB	0.473030494677428
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/842	24/9376	1.39192399049881	HS3ST3A1/NDST3/HS6ST2	0.603838201335213
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/842	55/9376	1.21477002807169	ASAH1/SPTLC2/B4GALT6/SGMS1/DEGS1/SPTLC3	0.501752019727306
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/842	98/9376	1.13626448203985	PLCB1/ITPR2/PRKCB/INPP5D/CALM1/PIK3C2B/CDS1/PLCB2/PRKCA/CALM3	0.425925741540326
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	8/842	77/9376	1.15692383625875	CDK6/CCND1/CDC42/RB1/RAC2/PLD1/RALA/RAC1	0.434291690653334
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	14/842	142/9376	1.09785554180188	WWP1/UBA52/UBB/MAP3K1/SKP2/NEDD4L/RPS27A/UBE2C/UBE2E3/PIAS2/CUL5/PIAS1/RBX1/UBA3	0.369062592068695
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	14/842	144/9376	1.08260754816574	C1QA/CD14/C1QC/C1QB/CCND1/CXCL8/LEF1/C3AR1/CTNNB1/LY96/C2/TNF/TLR4/GSK3B	0.3137750772005
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/842	16/9376	1.39192399049881	FUT9/NAGA	0.492821084421805
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	22/842	233/9376	1.05141039625661	TNNT3/LAMA2/ATP1B1/DCN/NEBL/ITGA9/ITGA6/FMNL2/TPM3/DSP/ITGA4/FBN2/NID2/DSC2/COL4A5/ITGA2/COL6A6/ITGB4/FBLN1/CAPZA2/ATP1B3/CAPZA1	0.249603066525224
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	16/842	168/9376	1.06051351657052	CSH1/CCND1/IL12RB2/SOS1/CSF3R/IL6ST/GRB2/IL10RA/PTPN6/PIAS2/CCND2/CSF2RA/PIAS1/IL10RB/IL2RB/CSF2RB	0.248593484419346
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/842	27/9376	1.23726576933228	ELOVL2/HACD3/HACD4	0.3877928106229
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/842	38/9376	1.17214651831479	PTPRC/CD4/ORAI1/BLNK	0.333986160879655
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/842	49/9376	1.13626448203985	ST6GAL1/MFNG/C1GALT1/GALNT1/XXYLT1	0.300382817180089
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	7/842	71/9376	1.09785554180188	SLC2A1/FGFR3/IDH1/MET/NRAS/FGFR2/KIT	0.259969127238123
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	8/842	82/9376	1.08637969990151	LGMN/B2M/CTSS/CALR/CD74/CD4/TNF/CTSL	0.246764480830887
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/842	28/9376	1.19307770614184	ELOVL2/HACD3/HACD4	0.321378751338892
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/842	28/9376	1.19307770614184	FUT9/ST3GAL6/B3GNT5	0.321378751338892
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/842	61/9376	1.09528445154005	FTL/SLC40A1/ATP1B1/ATOX1/ATP2B1/ATP1B3	0.234509743189195
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/842	73/9376	1.06777730777991	BICD1/TRIM5/BST2/PPIA/CD4/CXCR4/SERINC5	0.182599505996067
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/842	18/9376	1.23726576933228	MANBA/FUCA1	0.316479208137113
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/842	29/9376	1.15193709558522	GNGT1/CALM1/CALM3	0.257390232694761
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	15/842	163/9376	1.02472931815863	CXCL8/PRKCB/SOS1/MAP3K1/PCNA/RB1/TLR2/GRB2/BIRC5/NRAS/CASP10/YWHAB/PRKCA/TNF/TLR4	0.100039329757576
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	10/842	109/9376	1.02159558935693	CD36/SLC2A1/PRKCB/RPS6KA2/TBC1D4/PPP1CA/PYGL/TNF/RPS6KA1/GSK3B	0.0712318285259233
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/842	42/9376	1.06051351657052	IDO2/IDO1/KYNU/AOC1	0.123454948621376
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	20/842	224/9376	0.994231421784866	B2M/SLC2A1/CCND1/MAP3K1/SPI1/ITGB2/CALR/ADCY4/RB1/CD4/ATM/NRAS/NRP1/CCND2/TNF/CCNB2/IL2RB/MAD2L1/ITGAL/MSX2	-0.0274473331460052
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/842	20/9376	1.11353919239905	SQLE/CYP24A1	0.159654460560035
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	15/842	168/9376	0.994231421784866	FTL/CYBB/TNFSF10/IL33/NLRP3/PPIA/CHMP5/CASP1/PYCARD/PYGL/TNF/PARP1/TLR4/HMGB1/TNFRSF10A	-0.0236976966455827
Human Diseases	Substance dependence	hsa05034	Alcoholism	17/842	191/9376	0.991108181716432	GNGT1/GNG11/GNG2/GNAI2/HDAC9/SOS1/GNG10/GNAS/CALM1/GNG5/GRB2/PPP1CA/HDAC8/NRAS/CALM3/HDAC2/GRIN2C	-0.0389971659606015
Human Diseases	Immune disease	hsa05310	Asthma	3/842	32/9376	1.04394299287411	FCER1G/PRG2/TNF	0.0782102315256301
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/842	90/9376	0.989812615465822	SLC2A1/SCARB1/ATP1B1/SLC4A4/GNAS/ADCY4/ABCG2/ATP1B3	-0.0305024679269021
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/842	44/9376	1.01230835672641	CD28/CD86/ICA1/TNF	0.0257042189881489
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/842	21/9376	1.06051351657052	ENPP1/VNN2	0.0871977959372437
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/842	103/9376	0.972995410834121	DPP4/SLC16A10/ATP1B1/COL15A1/KCNQ1/PRCP/COL4A5/COL6A6/ATP1B3	-0.0865588388011356
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/842	104/9376	0.963639685729947	LPCAT2/PLA2G2A/LYPLA1/PLAAT3/SGMS1/CDS1/PLD1/CEPT1/PLD4	-0.117117812227863
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/842	46/9376	0.968294949912217	FTL/BLVRB/ALAS2/FECH	-0.0677067398047908
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	8/842	93/9376	0.957883176257247	RBPJ/MAF/IL12RB2/MAML3/DLL4/CD4/JAG2/IL2RB	-0.128208929795165
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	28/842	323/9376	0.965297132729827	MARCKS/CDK6/CCND1/ZEB2/STMN1/PRKCB/EZR/FSCN1/SOS1/WNT3A/FGFR3/EFNA5/IGF2BP1/ATM/GRB2/MET/PAK4/PDCD4/NRAS/CDC25B/HNRNPK/CCND2/BMPR2/PRKCA/HDAC2/CYP24A1/NOTCH4/RPS6KA5	-0.1993589441413
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	32/842	370/9376	0.963060923155935	AGTR1/CSH1/APLNR/APLN/ADRB1/SPX/LPAR6/NR3C1/P2RY1/CGA/LYPD6/KISS1/C3AR1/TAC3/CYSLTR1/CHRM3/S1PR1/P2RY14/PTAFR/P2RY13/TBXA2R/FPR1/PTGER4/GRIK4/GABRA3/HRH2/CALCR/GRM7/GRIN2C/ADRB2/OGFRL1/GRIA4	-0.227712196794382
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/842	59/9376	0.94367728169411	HPGDS/MGST2/LAP3/IDH1/GPX7	-0.136312891352633
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/842	83/9376	0.939129439372693	CCL4/CCL4L2/IL33/NLRP3/CASP1/PYCARD/PCBP1	-0.174957975220808
NA	NA	hsa03272	Virion - Hepatitis viruses	4/842	48/9376	0.927949326999208	DPP4/SCARB1/CLDN11/OCLN	-0.157191752715
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/842	72/9376	0.927949326999208	CXCL8/MAP3K1/TANK/RNF125/CASP10/TNF	-0.192767938878376
Organismal Systems	Sensory system	hsa04742	Taste transduction	7/842	86/9376	0.90636911009225	PLCB1/SCN9A/P2RY1/CHRM3/ADCY4/GABRA3/PLCB2	-0.273984430644984
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/842	50/9376	0.89083135391924	GATM/LAP3/CNDP2/AOC1	-0.24310874729762
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	17/842	205/9376	0.923422744916285	RBPJ/B2M/CDK6/CCND1/SYK/LYN/SKP2/CALR/RB1/TLR2/CCND2/TNF/BLNK/HDAC2/OAS3/ITGAL/RAC1	-0.348203990135084
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/842	38/9376	0.879109888736092	ENPP1/QPRT/NMRK1	-0.234542205933643
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/842	75/9376	0.89083135391924	MGST2/PMAIP1/TOP2A/ATM/BIRC5/MSH2	-0.298146076379156
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/842	76/9376	0.879109888736092	CD36/PLTP/FABP5/PPARG/MMP1/FABP4	-0.33236972965863
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/842	26/9376	0.856568609537731	PLA2G2A/PLAAT3	-0.230033158093559
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/842	39/9376	0.856568609537731	TYMS/GLDC/AHCYL2	-0.281927991519687
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/842	39/9376	0.856568609537731	CD28/CD86/TNF	-0.281927991519687
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	14/842	173/9376	0.901129982288248	CDK6/TNFSF10/CXCL8/IL33/PRKCB/NLRP3/TLR7/CASP1/PYCARD/PRKCA/TNF/TLR4/OAS3/TNFRSF10A	-0.412276250074102
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/842	66/9376	0.843590297272008	MAF/IL12RB2/TLR2/TNF/TLR4	-0.400521821486697
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	10/842	128/9376	0.869952494061758	GUCY1A2/PDE4D/ENPP1/PDE3B/ADCY4/PDE4B/DCK/NPR1/FHIT/ADK	-0.465316514867703
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/842	41/9376	0.814784774926134	GATM/GLDC/ALAS2	-0.373316182071583
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/842	41/9376	0.814784774926134	RAD51B/ATM/RPA3	-0.373316182071583
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/842	41/9376	0.814784774926134	GABRA3/GRIN2C/GRIA4	-0.373316182071583
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/842	43/9376	0.7768878086505	CD36/SCARB1/PLA2G2A	-0.460587620856639
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/842	15/9376	0.742359461599366	ST3GAL5	-0.313663561705438
NA	NA	hsa04382	Cornified envelope formation	17/842	217/9376	0.87235789266285	S100A9/S100A10/KRT18/ITGA6/KRT8/DSP/KRT23/SPTLC2/KRT7/COL4A5/TJP1/CLDN11/ITGB4/SPTLC3/KRT1/OCLN/KRT19	-0.597537502791899
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	13/842	169/9376	0.856568609537731	VAMP8/UBA52/TAX1BP1/UBB/WDFY3/RPS27A/TANK/ATG7/STX7/NRAS/GABARAPL2/CTSL/HMGB1	-0.591008672810531
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/842	30/9376	0.742359461599366	PLA2G2A/PLAAT3	-0.44394309121757
Cellular Processes	Cell motility	hsa04814	Motor proteins	15/842	194/9376	0.86098391164875	TNNT3/DNAH8/KIF26B/TUBA1B/TPM3/MYO5A/MYO10/MYL12A/MYL12B/MYO1F/MYO7A/CAPZA2/KIF26A/DNAH2/CAPZA1	-0.614557678911486
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/842	44/9376	0.759231267544807	PCNA/PARP1/HMGB1	-0.502810599505018
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/842	31/9376	0.718412382192935	SPCS3/SPCS1	-0.493253428357414
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/842	45/9376	0.742359461599366	CD28/CD86/TNF	-0.544153873387299
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/842	59/9376	0.754941825355288	ENPP1/DCK/TYMS/CMPK2	-0.593092615913852
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/842	32/9376	0.695961995249406	ATG7/GABARAPL2	-0.541130250555712
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/842	32/9376	0.695961995249406	PMAIP1/BIRC5	-0.541130250555712
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/842	62/9376	0.718412382192935	IGF1/ADCY4/NRAS/HDAC2	-0.698725585689348
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/842	34/9376	0.655023054352382	BHLHE41/RBX1	-0.632958103678719
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/842	49/9376	0.681758689223908	GNAI2/GNAS/GRIN2C	-0.701534398714794
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/842	63/9376	0.707009011047016	PCNA/GTF2H5/RPA3/RBX1	-0.732900641131742
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	6/842	90/9376	0.742359461599366	IGF1/KL/PPARG/ADCY4/NRAS/EIF4EBP1	-0.77141215518762
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/842	90/9376	0.742359461599366	CD28/TLR2/CD4/PTPN6/NRAS/TLR4	-0.77141215518762
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	13/842	180/9376	0.80422275006598	B2M/SYK/POU2F2/CALR/BST2/SRSF9/SRSF8/TLR2/CD74/PPP1CA/TNF/OAS3/EIF4EBP1	-0.833037130988066
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/842	19/9376	0.586073259157395	GLDC	-0.567279819773233
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	10/842	143/9376	0.778698735943392	C1QA/FCGR2A/C1QC/FCGR3A/C1QB/CD28/CD86/FCGR1A/C2/TNF	-0.837617727450395
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/842	78/9376	0.713807174614775	PLCB1/INPP5D/PIK3C2B/PIK3CG/PLCB2	-0.797217158176999
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/842	105/9376	0.742359461599366	UBA52/TAX1BP1/UBB/RPS27A/TOMM7/NRAS/GABARAPL2	-0.833894139592719
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	10/842	144/9376	0.773291105832673	PLCB1/RBPJ/ITPR2/PRKCB/RYR1/GNAQ/PLCB2/PSMA4/PRKCA/GRIN2C	-0.86112712880265
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/842	36/9376	0.618632884666139	KL/AKR1B1	-0.720089401313768
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/842	36/9376	0.618632884666139	ENPP1/PYGL	-0.720089401313768
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/842	36/9376	0.618632884666139	C1GALT1/GALNT1	-0.720089401313768
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/842	36/9376	0.618632884666139	PCNA/RPA3	-0.720089401313768
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/842	20/9376	0.556769596199525	NPL	-0.623253605449845
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/842	54/9376	0.618632884666139	CGA/CD28/CD86	-0.882776852942976
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/842	70/9376	0.636308109942314	CD36/SLC2A1/TNF/TNFRSF1B	-0.959326579664703
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/842	23/9376	0.484147474956109	PDSS2	-0.777999604533881
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/842	85/9376	0.655023054352382	ENPP1/DCK/TYMS/CMPK2/ADK	-1.00353764895886
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/842	57/9376	0.586073259157395	ELOVL2/HACD3/HACD4	-0.984558714665068
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/842	26/9376	0.428284304768865	HHEX	-0.916909237802223
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/842	26/9376	0.428284304768865	SCARB1	-0.916909237802223
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/842	44/9376	0.506154178363205	GNAS/ARHGDIG	-1.03132541799819
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/842	27/9376	0.412421923110759	HMGCLL1	-0.960351569206656
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/842	46/9376	0.484147474956109	POMP/PSMA4	-1.10161291636785
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/842	28/9376	0.397692568713946	AKR1B1	-1.00254355646139
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/842	78/9376	0.57104573969182	LSM6/PABPC4L/LSM3/LSM4	-1.19489262503524
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/842	63/9376	0.530256758285262	PRDM6/MECOM/BBOX1	-1.17503655743925
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/842	47/9376	0.47384646485066	TNF/CACNA1D	-1.13581928907147
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/842	94/9376	0.592308081063324	S100A9/CXCL8/MMP1/TNF/GSK3B	-1.24778744813213
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/842	48/9376	0.463974663499604	HMGCLL1/HIBADH	-1.16943754492368
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/842	30/9376	0.371179730799683	IDH1	-1.08352674568222
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/842	30/9376	0.371179730799683	PIGX	-1.08352674568222
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/842	66/9376	0.506154178363205	HSD17B2/HSD17B1/CYP19A1	-1.26460203277507
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/842	31/9376	0.359206191096468	KL	-1.12247031873552
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/842	31/9376	0.359206191096468	CNDP2	-1.12247031873552
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/842	31/9376	0.359206191096468	GLDC	-1.12247031873552
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/842	32/9376	0.347980997624703	AKR1B1	-1.16047073263705
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/842	33/9376	0.337436118908803	IDH1	-1.19758657066589
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/842	70/9376	0.477231082456736	HPGDS/MGST2/SULT1A1	-1.37893126388453
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	6/842	119/9376	0.561448332302042	CASP10/VCAM1/TNF/TNFRSF1B/RPS6KA5/RHBDF2	-1.51225308929736
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/842	35/9376	0.318154054971157	AKR1B1	-1.2693721418947
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/842	37/9376	0.30095653848623	ASPA	-1.33819750838984
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/842	37/9376	0.30095653848623	UXS1	-1.33819750838984
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/842	38/9376	0.293036629578697	UXS1	-1.37159893956024
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/842	83/9376	0.40248404544544	MTF2/RNF2/HDAC2	-1.71741775488258
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/842	83/9376	0.40248404544544	HMGCLL1/IDH1/AGPS	-1.71741775488258
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/842	65/9376	0.342627443815092	LIPG/AKR1B1	-1.67045757023985
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/842	44/9376	0.253077089181602	GTF2H5	-1.55984023649135
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/842	45/9376	0.247453153866456	ABCG2	-1.58942875904174
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	7/842	154/9376	0.506154178363205	IDO2/IDO1/KYNU/QPRT/CMPK2/ALAS2/FECH	-1.94090621090444
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/842	122/9376	0.45636852147502	CD36/IGF1/CCND1/PPARG/EIF4EBP1	-1.89838865005692
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	4/842	109/9376	0.408638235742771	CD4/IL6ST/AHR/IL2RB	-1.95057329032087
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/842	73/9376	0.30507923079426	HPGDS/MGST2	-1.87219282263947
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/842	54/9376	0.20621096155538	AHCYL2	-1.83743841847854
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/842	54/9376	0.20621096155538	RPA3	-1.83743841847854
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/842	79/9376	0.281908656303557	HPGDS/MGST2	-2.01320122676251
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/842	103/9376	0.324331803611374	PPP1CA/PABPC4L/SAP18	-2.16574501967078
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/842	108/9376	0.309316442333069	SUMO2/SAP18/KPNA3	-2.26758380825095
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	6/842	174/9376	0.383979031861741	MAN1A1/TUSC3/CALR/RPN2/TRAM1/RBX1	-2.57628775483671
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/842	75/9376	0.148471892319873	IDH1	-2.32557399350344
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/842	82/9376	0.135797462487689	MGST2	-2.46880332699821
Genetic Information Processing	Transcription	hsa03040	Spliceosome	9/842	243/9376	0.412421923110759	SRSF9/SRSF8/HNRNPA1/LSM6/HNRNPK/LSM3/LSM4/SNRPE/PCBP1	-2.91492480629272
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/842	116/9376	0.191989515930871	IDH1/GLDC	-2.75046334667979
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/842	117/9376	0.0951742899486368	HDAC2	-3.09343635945464
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/842	449/9376	0.0992017097905612	CALM1/ARRB2/GRK3/CALM3	-6.14417137958693