category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	149/1479	275/9376	3.43481221955867	C1QA/CYBB/CYBA/C1QC/ATP5F1E/TUBA1B/MT-CO2/COX6C/C1QB/COX5B/UQCR10/NDUFS5/COX4I1/UQCR11/MT-ATP6/NDUFA4/RYR2/COX7C/UQCRB/NDUFA13/COX6B1/MT-CYB/ATP5MC2/HSPA1A/EGR1/NDUFC2/SLC25A6/ATP5MC3/COX8A/NDUFB7/NDUFB2/COX7B/ATP5F1D/ATP5PF/COX7A2/NDUFB11/PSMA7/UQCRQ/UQCRH/NDUFA1/NDUFS6/NDUFB10/NCF4/COX6A1/NDUFA2/NDUFB4/NDUFA3/MT-CO1/NDUFA11/ATP5PD/NDUFA4L2/TUBB/PSMB6/MT-CO3/ATP5MC1/SLC25A5/MT-ND1/NDUFB8/NDUFB1/PSMB3/HSPA8/PSMB1/COX4I2/NDUFB3/PSMA2/NDUFA6/NDUFV2/NDUFC1/PSMB4/ATP5F1C/PSMA1/SOD1/ATP5F1B/ATP5PB/NDUFA12/MT-ND2/ATP5PO/NDUFS8/SEM1/RAC1/PSMA4/NDUFAB1/TUBA1A/COX5A/TUBB2A/COX7A2L/PRNP/NCF1/PSMC5/NDUFB5/CYCS/PSMD4/PSMD8/NDUFB9/BAX/UQCRFS1/NDUFA5/PSMC3/PSMB5/ATP5F1A/PSMC4/GRIN2C/NCAM2/NDUFB6/PSMB2/PIK3R2/MT-ND5/NDUFS3/NDUFA7/RYR1/PIK3CD/NDUFS7/PPP3R1/VDAC3/ADRM1/CSNK2B/VDAC2/VDAC1/CYC1/UQCRC1/HSPA6/PSMA3/PSMC2/KIF5B/IL1B/NDUFV3/NDUFA8/MAPK10/NDUFS2/PSMD7/NCF2/NDUFS4/PSMA6/PSMD2/SDHD/TNF/RAC2/PSMD6/BAD/PRKACA/C9/PSMD13/EIF2S1/CREB1/ATF6B/UQCRC2/SDHC/COX7B2/PSMD3	17.7347846218181
Genetic Information Processing	Translation	hsa03010	Ribosome	130/1479	222/9376	3.71227210983803	RPS23/RPS11/RPLP1/RPS12/RPS15A/RPS18/RPS15/RPL28/RPL10/RPL30/RPL13/RPS14/RPL13A/RPS27A/RPS4X/RPL27A/RPL39/RPL26/RPL32/RPL11/RPL23A/RPS9/RPS19/RPL23/RPS8/RPL17/UBA52/RPS2/RPL19/RPL34/RPL14/RPL15/FAU/RPL3/RPL35/RPS25/RPL21/RPL18/RPL41/RPL29/RPL7A/RPS24/RPL7/RPS13/RPL24/RPS7/RPL9/RPL12/RPL22/RPLP2/RPS6/RPL27/RPS20/RPL36A/RPLP0/RPL10A/RPL37/RPL36/RPL18A/RPS16/RPL35A/RPL37A/RPL31/RPL6/RPL38/RPL5/RACK1/RPS17/RPS5/RPS3A/RPS28/RPL8/RPL36AL/RPS21/RPS3/RPSA/RPS26/RPS10/RPL4/RPS27L/RPS27/RPL22L1/MRPL14/MRPS21/MRPL52/MRPL54/MRPL51/MRPS24/MRPS18C/MRPL18/MRPL20/MRPL43/RPL26L1/MRPL40/MRPL41/RSL24D1/MRPL27/MRPL47/MRPS16/MRPL55/MRPS34/MRPS26/MRPL17/MRPS15/MRPL33/MRPL50/MRPL34/MRPL36/MRPS17/MRPS7/MRPS12/MRPL16/MRPL21/MRPS18A/MRPL19/MRPS33/MRPL11/MRPL22/MRPL2/MRPL28/MRPS23/MRPL35/MRPS18B/MRPL15/MRPL23/MRPL42/MRPS14/MRPS25/MRPL9/MRPS6	17.6987643761536
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	143/1479	268/9376	3.38260018366585	RPS27A/UBA52/ATP5F1E/TUBA1B/UBB/MT-CO2/COX6C/COX5B/UQCR10/NDUFS5/COX4I1/UQCR11/MT-ATP6/GNAI2/NDUFA4/CALM2/COX7C/UQCRB/NDUFA13/COX6B1/MT-CYB/ATP5MC2/NDUFC2/SLC25A6/ATP5MC3/COX8A/NDUFB7/NDUFB2/COX7B/ATP5F1D/ATP5PF/COX7A2/NDUFB11/PSMA7/UQCRQ/UQCRH/NDUFA1/NDUFS6/NDUFB10/COX6A1/NDUFA2/NDUFB4/NDUFA3/MT-CO1/NDUFA11/ATP5PD/PARK7/NDUFA4L2/TUBB/PSMB6/MT-CO3/CALM1/ATP5MC1/SLC25A5/MT-ND1/CALM3/NDUFB8/NDUFB1/PSMB3/PSMB1/COX4I2/NDUFB3/PSMA2/NDUFA6/NDUFV2/NDUFC1/PSMB4/ATP5F1C/PSMA1/GNAS/SOD1/ATP5F1B/ATP5PB/TXN2/NDUFA12/MT-ND2/ATP5PO/NDUFS8/SEM1/PSMA4/NDUFAB1/TUBA1A/COX5A/TUBB2A/COX7A2L/PSMC5/NDUFB5/CYCS/PSMD4/PSMD8/NDUFB9/BAX/UQCRFS1/NDUFA5/PSMC3/PSMB5/ATP5F1A/PSMC4/NDUFB6/PSMB2/SLC39A4/MT-ND5/NDUFS3/NDUFA7/MAP3K5/NDUFS7/VDAC3/ADRM1/VDAC2/CALML4/ATF6/VDAC1/SLC39A3/CYC1/UQCRC1/CAMK2D/PSMA3/PSMC2/SLC39A6/NFE2L2/KIF5B/NDUFV3/NDUFA8/MAPK10/NDUFS2/PSMD7/NDUFS4/PSMA6/PRKN/UBE2J1/PSMD2/SDHD/PSMD6/PRKACA/PSMD13/EIF2S1/GNAI3/LRRK2/DAXX/UQCRC2/SDHC/COX7B2/PSMD3	17.1255967312043
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	94/1479	138/9376	4.31815464816611	ATP5F1E/MT-CO2/COX6C/COX5B/UQCR10/NDUFS5/ATP5MF/ATP5MG/COX4I1/UQCR11/MT-ATP6/NDUFA4/COX7C/UQCRB/NDUFA13/COX6B1/MT-CYB/ATP5MC2/NDUFC2/ATP5MC3/COX8A/NDUFB7/NDUFB2/COX7B/ATP5F1D/ATP6V1F/ATP5PF/COX7A2/NDUFB11/UQCRQ/UQCRH/ATP6V1G1/NDUFA1/ATP6V0B/NDUFS6/NDUFB10/COX6A1/ATP5ME/NDUFA2/NDUFB4/NDUFA3/MT-CO1/NDUFA11/ATP5PD/ATP6V0C/NDUFA4L2/MT-CO3/ATP5MC1/MT-ND1/NDUFB8/NDUFB1/COX4I2/NDUFB3/NDUFA6/NDUFV2/NDUFC1/ATP5F1C/ATP5F1B/ATP5PB/NDUFA12/MT-ND2/ATP5PO/NDUFS8/NDUFAB1/COX5A/COX7A2L/COX17/NDUFB5/CYCS/ATP6V0E1/NDUFB9/UQCRFS1/NDUFA5/ATP5F1A/NDUFB6/ATP6AP1/MT-ND5/NDUFS3/NDUFA7/NDUFS7/ATP6V1B2/CYC1/UQCRC1/NDUFV3/NDUFA8/NDUFS2/NDUFS4/SDHD/PPA1/ATP6V1D/ATP6V0D1/UQCRC2/SDHC/COX7B2	16.9936176913111
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	118/1479	205/9376	3.64903115156912	CD36/COL3A1/CYBB/CYBA/ATP5F1E/COL1A1/MT-CO2/COX6C/COX5B/UQCR10/NDUFS5/COL1A2/COX4I1/UQCR11/MT-ATP6/NDUFA4/RYR2/MMP2/COX7C/UQCRB/NDUFA13/COX6B1/MT-CYB/ATP5MC2/NDUFC2/SLC25A6/ATP5MC3/COX8A/NDUFB7/NDUFB2/COX7B/ATP5F1D/ATP5PF/COX7A2/NDUFB11/UQCRQ/UQCRH/NDUFA1/NDUFS6/NDUFB10/NCF4/COX6A1/NDUFA2/NDUFB4/NDUFA3/MT-CO1/NDUFA11/ATP5PD/NDUFA4L2/MT-CO3/ATP5MC1/SLC25A5/MT-ND1/PRKCB/NDUFB8/NDUFB1/COX4I2/CTSD/PPP1CA/NDUFB3/NDUFA6/NDUFV2/NDUFC1/ATP5F1C/ATP5F1B/ATP5PB/PLCB1/NDUFA12/MT-ND2/ATP5PO/NDUFS8/RAC1/GAPDH/NDUFAB1/COX5A/COX7A2L/NCF1/NDUFB5/AGTR1/NDUFB9/UQCRFS1/NDUFA5/ATP5F1A/MPC2/NDUFB6/PRKCA/PPP1CC/PIK3R2/MT-ND5/NDUFS3/NDUFA7/IRS1/PIK3CD/NDUFS7/VDAC3/VDAC2/PARP1/VDAC1/CYC1/UQCRC1/CAMK2D/MPC1/PLCB2/NDUFV3/NDUFA8/MAPK10/NDUFS2/AKT1/NCF2/NDUFS4/PDK2/TGFB3/SDHD/RAC2/PTPA/UQCRC2/SDHC/COX7B2	16.595651467953
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	139/1479	308/9376	2.86097134778676	ATP5F1E/TUBA1B/MT-CO2/COX6C/COX5B/UQCR10/NDUFS5/COX4I1/UQCR11/MT-ATP6/NDUFA4/COX7C/UQCRB/NDUFA13/COX6B1/MT-CYB/ATP5MC2/CLTA/NDUFC2/SLC25A6/ATP5MC3/COX8A/NDUFB7/POLR2L/NDUFB2/COX7B/ATP5F1D/ATP5PF/COX7A2/NDUFB11/PSMA7/UQCRQ/UQCRH/AP2S1/NDUFA1/NDUFS6/NDUFB10/COX6A1/NDUFA2/NDUFB4/NDUFA3/POLR2K/MT-CO1/NDUFA11/ATP5PD/NDUFA4L2/TUBB/PSMB6/CLTC/MT-CO3/ATP5MC1/SLC25A5/MT-ND1/AP2M1/NDUFB8/NDUFB1/PSMB3/POLR2I/PSMB1/COX4I2/NDUFB3/PSMA2/POLR2J/NDUFA6/NDUFV2/NDUFC1/PSMB4/ATP5F1C/PSMA1/SOD1/SOD2/ATP5F1B/ATP5PB/PLCB1/NDUFA12/MT-ND2/ATP5PO/NDUFS8/SEM1/PSMA4/NDUFAB1/TUBA1A/COX5A/TUBB2A/COX7A2L/PSMC5/NDUFB5/CYCS/PSMD4/DCTN3/PSMD8/NDUFB9/BAX/UQCRFS1/NDUFA5/PSMC3/PSMB5/ATP5F1A/PSMC4/BDNF/POLR2E/NDUFB6/PSMB2/MT-ND5/NDUFS3/NDUFA7/MAP3K5/NDUFS7/VDAC3/ADRM1/POLR2F/VDAC2/DNAH8/POLR2G/VDAC1/CYC1/UQCRC1/PSMA3/PSMC2/TFAM/PLCB2/KIF5B/DCTN6/NDUFV3/NDUFA8/MAPK10/NDUFS2/PSMD7/NDUFS4/PSMA6/PSMD2/SDHD/PSMD6/PSMD13/CREB1/UQCRC2/SDHC/COX7B2/PSMD3	14.3713625419372
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	114/1479	227/9376	3.18367273994513	HGF/CYBA/ATP5F1E/MT-CO2/COX6C/COX5B/UQCR10/NDUFS5/COX4I1/UQCR11/JUN/MT-ATP6/NDUFA4/COX7C/UQCRB/NDUFA13/COX6B1/MT-CYB/ATP5MC2/NDUFC2/SLC25A6/ATP5MC3/COX8A/NDUFB7/NDUFB2/COX7B/ATP5F1D/ATP5PF/COX7A2/NDUFB11/UQCRQ/UQCRH/NDUFA1/PTPRJ/NDUFS6/NDUFB10/COX6A1/NDUFA2/NDUFB4/NDUFA3/MT-CO1/NDUFA11/ATP5PD/NDUFA4L2/MT-CO3/ATP5MC1/SLC25A5/GSTO1/HIF1A/MT-ND1/AKR1A1/NDUFB8/NDUFB1/COX4I2/NDUFB3/PLD1/NDUFA6/NDUFV2/NDUFC1/ATP5F1C/SOD1/SOD2/ATP5F1B/ATP5PB/NDUFA12/MT-ND2/ATP5PO/NDUFS8/RAC1/NDUFAB1/COX5A/COX7A2L/NCF1/MAP2K2/MGST3/NDUFB5/NDUFB9/UQCRFS1/NDUFA5/HMOX1/MGST2/ATP5F1A/CAT/ACP1/NDUFB6/PIK3R2/MT-ND5/NDUFS3/NDUFA7/MAP3K5/PIK3CD/NDUFS7/VDAC3/VDAC2/VDAC1/CYC1/UQCRC1/PTPN1/NFE2L2/NDUFV3/NDUFA8/MAPK10/NDUFS2/AKT1/NCF2/NDUFS4/SDHD/BAD/CBR1/HRAS/PRKD1/UQCRC2/SDHC/COX7B2	14.4129315331272
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	117/1479	238/9376	3.11643683842705	F13A1/CCL2/RPS23/C1QA/RPS11/RPLP1/RPS12/CYBB/RPS15A/RPS18/RPS15/RPL28/RPL10/RPL30/RPL13/RPS14/NRP1/RPL13A/RPS27A/RPS4X/RPL27A/RPL39/RPL26/RPL32/RPL11/RPL23A/RPS9/RPS19/RPL23/RPS8/RPL17/UBA52/RPS2/RPL19/C1QC/RPL34/RPL14/RPL15/FAU/RPL3/RPL35/RPS25/RPL21/RPL18/RPL41/RPL29/RPL7A/RPS24/RPL7/RPS13/RPL24/RPS7/RPL9/RPL12/RPL22/RPLP2/RPS6/CFD/RPL27/RPS20/RPL36A/C1QB/RPLP0/RPL10A/RPL37/RPL36/RPL18A/RPS16/RPL35A/RPL37A/RPL31/RPL6/RPL38/RPL5/RPS17/RPS5/RPS3A/RPS28/JUN/RPL8/RPL36AL/FCGR2A/CXCL8/RPS21/RPS3/RPSA/RPS26/SYK/RPS10/RPL4/C3AR1/RPS27L/NLRP3/RPS27/PRKCB/MMP1/C1R/RPL22L1/TNFRSF1A/CASP1/TLR4/TLR2/C2/RPL26L1/RSL24D1/AGTR1/PRKCA/PIK3R2/PIK3CD/TLR7/IL1B/IRF9/MAPK10/TLR8/TNF/HBEGF/C9	14.3122156070976
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	153/1479	388/9376	2.49982225382154	CYBB/WNT2/ATP5F1E/TUBA1B/MT-CO2/COX6C/COX5B/UQCR10/NDUFS5/COX4I1/UQCR11/MT-ATP6/NDUFA4/CALM2/COX7C/UQCRB/NDUFA13/APOE/COX6B1/MT-CYB/ATP5MC2/NDUFC2/SLC25A6/ATP5MC3/COX8A/NDUFB7/NDUFB2/COX7B/ATP5F1D/ATP5PF/COX7A2/NDUFB11/PSMA7/UQCRQ/UQCRH/NDUFA1/NDUFS6/NDUFB10/COX6A1/NDUFA2/NDUFB4/NDUFA3/MT-CO1/NDUFA11/ATP5PD/NDUFA4L2/TUBB/PSMB6/MT-CO3/CALM1/ATP5MC1/SLC25A5/MT-ND1/CALM3/NDUFB8/NDUFB1/PSMB3/PSMB1/COX4I2/NDUFB3/PSMA2/NDUFA6/NDUFV2/NDUFC1/PSMB4/ATP5F1C/PSMA1/ATP5F1B/TNFRSF1A/ATP5PB/PLCB1/NDUFA12/MT-ND2/ATP5PO/NDUFS8/SEM1/GAPDH/PSMA4/PSENEN/NDUFAB1/TUBA1A/COX5A/TUBB2A/COX7A2L/MAP2K2/PSMC5/NDUFB5/CYCS/PSMD4/LRP6/PSMD8/NDUFB9/LRP1/UQCRFS1/NDUFA5/PSMC3/PSMB5/ATP5F1A/PSMC4/GRIN2C/CSF1/NDUFB6/PSMB2/SLC39A4/PIK3R2/BID/MT-ND5/NDUFS3/NDUFA7/IRS1/MAP3K5/PIK3CD/NDUFS7/PPP3R1/VDAC3/APH1A/ADRM1/CSNK2B/VDAC2/CALML4/ATF6/HSD17B10/VDAC1/SLC39A3/CYC1/UQCRC1/PSMA3/PSMC2/SLC39A6/PLCB2/KIF5B/IL1B/NDUFV3/NDUFA8/MAPK10/NDUFS2/AKT1/FZD2/PSMD7/NDUFS4/PSMA6/PSMD2/SDHD/TNF/PSMD6/BAD/PSMD13/HRAS/EIF2S1/UQCRC2/SDHC/COX7B2/PSMD3	13.0575825561886
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	145/1479	368/9376	2.49786871270247	ATP5F1E/TUBA1B/MT-CO2/COX6C/ACTB/COX5B/UQCR10/NDUFS5/COX4I1/UQCR11/MT-ATP6/NDUFA4/PFN1/COX7C/UQCRB/NDUFA13/COX6B1/MT-CYB/ATP5MC2/NDUFC2/ATP5MC3/COX8A/NDUFB7/NDUFB2/COX7B/ATP5F1D/ATP5PF/ACTG1/COX7A2/NDUFB11/PSMA7/UQCRQ/UQCRH/NDUFA1/NDUFS6/NDUFB10/COX6A1/NDUFA2/NDUFB4/NDUFA3/MT-CO1/NDUFA11/CHCHD10/ATP5PD/NDUFA4L2/TUBB/PSMB6/MT-CO3/ATP5MC1/MT-ND1/NDUFB8/NDUFB1/PSMB3/PSMB1/COX4I2/HNRNPA1/NDUFB3/PSMA2/NDUFA6/NDUFV2/NDUFC1/PSMB4/ATP5F1C/PSMA1/SOD1/ATP5F1B/TNFRSF1B/TNFRSF1A/CASP1/ATP5PB/NDUFA12/MT-ND2/ATP5PO/NDUFS8/SEM1/RAC1/PSMA4/NDUFAB1/TUBA1A/TANK/COX5A/TUBB2A/COX7A2L/HNRNPA3/SRSF3/PSMC5/NDUFB5/CYCS/PSMD4/DCTN3/PSMD8/NDUFB9/BAX/UQCRFS1/NDUFA5/PSMC3/PSMB5/ATP5F1A/PSMC4/GRIN2C/CAT/VCP/NDUFB6/PSMB2/BID/MT-ND5/NDUFS3/NDUFA7/MAP3K5/NDUFS7/PPP3R1/ADRM1/ATF6/DNAH8/VDAC1/CYC1/UQCRC1/PSMA3/PSMC2/RAB8A/C9orf72/ANXA7/KIF5B/DCTN6/NDUFV3/NDUFA8/NDUFS2/PSMD7/ALYREF/NDUFS4/SIGMAR1/PSMA6/PRKN/PSMD2/SDHD/TNF/PSMD6/BAD/PSMD13/EIF2S1/DAXX/UQCRC2/SDHC/COX7B2/PSMD3	12.6859246104031
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	83/1479	157/9376	3.35141234178714	MT-CO2/COX6C/COX5B/UQCR10/NDUFS5/COX4I1/UQCR11/JUN/NDUFA4/COX7C/UQCRB/NDUFA13/CXCL8/COX6B1/MT-CYB/NDUFC2/COX8A/NDUFB7/NDUFB2/COX7B/COX7A2/NDUFB11/UQCRQ/UQCRH/NDUFA1/NDUFS6/NDUFB10/COX6A1/NDUFA2/NDUFB4/NDUFA3/MT-CO1/NDUFA11/NDUFA4L2/MT-CO3/NDUFB8/NDUFB1/COX4I2/NDUFB3/NDUFA6/NDUFV2/NDUFC1/TNFRSF1A/NDUFA12/NDUFS8/RAC1/NDUFAB1/SOCS3/COX5A/COX7A2L/CDC42/NDUFB5/CYCS/NDUFB9/BAX/UQCRFS1/NDUFA5/NDUFB6/PIK3R2/BID/NDUFS3/NDUFA7/IRS1/MAP3K5/PIK3CD/NDUFS7/ADIPOR1/CYC1/UQCRC1/IL1B/NDUFV3/NDUFA8/MAPK10/NDUFS2/AKT1/NDUFS4/CEBPA/SDHD/TNF/EIF2S1/UQCRC2/SDHC/COX7B2	12.8580576388972
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	169/1479	480/9376	2.23200360604012	CYBB/RPS27A/UBA52/WNT2/ATP5F1E/TUBA1B/UBB/MT-CO2/COX6C/COX5B/UQCR10/NDUFS5/COX4I1/UQCR11/MT-ATP6/NDUFA4/CALM2/RYR2/COX7C/UQCRB/NDUFA13/COX6B1/MT-CYB/ATP5MC2/NDUFC2/SLC25A6/ATP5MC3/COX8A/NDUFB7/NDUFB2/COX7B/ATP5F1D/ATP5PF/COX7A2/NDUFB11/PSMA7/UQCRQ/UQCRH/NDUFA1/NDUFS6/NDUFB10/COX6A1/NDUFA2/NDUFB4/NDUFA3/MT-CO1/NDUFA11/ATP5PD/PARK7/NDUFA4L2/TUBB/PSMB6/MT-CO3/CALM1/ATP5MC1/SLC25A5/MT-ND1/CALM3/PRKCB/NDUFB8/NDUFB1/PSMB3/PSMB1/COX4I2/NDUFB3/PSMA2/NDUFA6/NDUFV2/NDUFC1/PSMB4/ATP5F1C/PSMA1/SOD1/ATP5F1B/TNFRSF1B/TNFRSF1A/ATP5PB/PLCB1/NDUFA12/MT-ND2/ATP5PO/NDUFS8/SEM1/RAC1/PSMA4/NDUFAB1/TUBA1A/TANK/COX5A/TUBB2A/COX7A2L/PRNP/MAP2K2/PSMC5/NDUFB5/CYCS/PSMD4/DCTN3/LRP6/PSMD8/NDUFB9/BAX/UQCRFS1/NDUFA5/PSMC3/PSMB5/ATP5F1A/PSMC4/GRIN2C/BDNF/CAT/CSF1/VCP/NDUFB6/PRKCA/PSMB2/BID/MT-ND5/NDUFS3/NDUFA7/MAP3K5/RYR1/NDUFS7/PPP3R1/VDAC3/ADRM1/CSNK2B/VDAC2/CALML4/ATF6/DNAH8/HSD17B10/VDAC1/CYC1/UQCRC1/CAMK2D/PSMA3/PSMC2/PLCB2/RAB8A/C9orf72/KIF5B/IL1B/DCTN6/NDUFV3/NDUFA8/MAPK10/NDUFS2/FZD2/PSMD7/NDUFS4/SIGMAR1/PSMA6/PRKN/UBE2J1/PSMD2/SDHD/TNF/PSMD6/BAD/PSMD13/HRAS/EIF2S1/LRRK2/DAXX/UQCRC2/SDHC/COX7B2/PSMD3	11.9915098012719
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	102/1479	235/9376	2.75157740278797	ATP5F1E/RPS6/MT-CO2/COX6C/ACTB/COX5B/UQCR10/PRKG1/NDUFS5/ATP5MF/ATP5MG/COX4I1/UQCR11/MT-ATP6/NDUFA4/COX7C/UQCRB/NDUFA13/COX6B1/MT-CYB/ATP5MC2/NDUFC2/ATP5MC3/COX8A/NDUFB7/NDUFB2/COX7B/ATP5F1D/ATP5PF/ACTG1/COX7A2/NDUFB11/UQCRQ/UQCRH/NDUFA1/NDUFS6/NDUFB10/COX6A1/ATP5ME/NDUFA2/NDUFB4/NDUFA3/MT-CO1/NDUFA11/ATP5PD/NDUFA4L2/MT-CO3/ATP5MC1/MT-ND1/NDUFB8/NDUFB1/COX4I2/NDUFAF3/NDUFB3/NDUFA6/NDUFV2/NDUFC1/ATP5F1C/GNAS/ATP5F1B/ATP5PB/NDUFA12/MT-ND2/ATP5PO/NDUFS8/NDUFAB1/COX14/COX5A/COX7A2L/COX17/NDUFAF8/NDUFB5/NDUFB9/UQCRFS1/NDUFA5/COA3/COX16/ATP5F1A/COX20/NDUFB6/MT-ND5/NDUFS3/NDUFA7/MAP3K5/NDUFS7/CYC1/UQCRC1/NDUFV3/NDUFA8/COA6/NDUFS2/NDUFS4/COA4/SDHD/PRKACA/NDUFAF4/HRAS/CREB1/UQCRC2/RPS6KA3/SDHC/COX7B2	11.7680652176877
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	31/1479	46/9376	4.27221683276009	PSMA7/POMP/PSMB6/PSMB3/PSMB1/PSMA2/PSMB4/PSMA1/PSMB8/SEM1/PSMA4/PSME1/PSMC5/PSMD4/PSMB10/PSMD8/PSMC3/PSMB5/PSME2/PSMC4/PSMB2/ADRM1/PSMA3/PSMF1/PSMC2/PSMD7/PSMA6/PSMD2/PSMD6/PSMD13/PSMD3	9.6276174308823
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	57/1479	155/9376	2.33127003860499	CD36/CD14/CYBB/FCGR3A/CYBA/TUBA1B/ACTB/MRC1/FCGR2A/HLA-C/COLEC12/SEC61B/MSR1/ATP6V1F/ACTG1/FCGR1A/ATP6V1G1/HLA-A/ATP6V0B/NCF4/CD209/SEC61G/ATP6V0C/TUBB/CLEC7A/C1R/HLA-DRA/CALR/TLR4/CTSS/RAC1/ITGB5/TUBA1A/TUBB2A/LAMP1/ITGB2/TLR2/RAB5C/NCF1/CORO1A/HLA-E/ATP6V0E1/M6PR/ITGAM/ATP6AP1/HLA-DMB/HLA-DPA1/HLA-DMA/FCGR2B/ATP6V1B2/VAMP3/HLA-DQA2/STX7/NCF2/ATP6V1D/ATP6V0D1/SEC61A1	7.23238692207259
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	55/1479	149/9376	2.34005381833363	GNG2/NDUFS5/GNAI2/NDUFA4/NDUFA13/GNG5/GNG10/NDUFC2/NDUFB7/NDUFB2/NDUFB11/GNG11/NDUFA1/NDUFS6/NDUFB10/NDUFA2/NDUFB4/NDUFA3/NDUFA11/NDUFA4L2/MT-ND1/PRKCB/NDUFB8/NDUFB1/GNB2/NDUFB3/NDUFA6/NDUFV2/NDUFC1/PLCB1/NDUFA12/MT-ND2/NDUFS8/NDUFAB1/NDUFB5/GNB4/GNGT1/KCNJ5/NDUFB9/NDUFA5/NDUFB6/PRKCA/MT-ND5/NDUFS3/NDUFA7/NDUFS7/PLCB2/GABRA3/NDUFV3/NDUFA8/MAPK10/NDUFS2/NDUFS4/PRKACA/GNAI3	7.1354894875818
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	77/1479	250/9376	1.95254090601758	LGMN/CTSC/LAPTM5/CD63/CTSZ/BLOC1S1/CLTA/NPC2/CD68/ATP6V1F/VAMP8/ATP6V1G1/AP2S1/ASAH1/ATP6V0B/CTSB/ATP6V0C/NEU1/CLTC/LAMTOR4/LAMTOR5/AP2M1/AP1S2/CTSD/LAMTOR2/LAMTOR1/VPS29/CTSS/LAMP1/FUCA1/AP1B1/OSBPL6/FUCA2/CTSH/HEXA/SUMF1/ACP2/CTSA/VPS35/ATP6V0E1/NAGA/HYAL2/PPT1/M6PR/MAN2B1/SLC15A3/LAMTOR3/MANBA/ARSB/ATP6AP1/PLA2G15/GAA/GPR155/CTBS/GLA/LITAF/CTSO/GNS/BORCS7/TPP1/RRAGA/TLR7/ATP6V1B2/NAGLU/AP1S1/MCOLN1/LIPA/DMXL2/TLR8/MCOLN2/SCARB2/CLN6/GUSB/CTSF/ATP6V1D/GNPTAB/ATP6V0D1	6.60620526014081
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	57/1479	181/9376	1.99639146952361	CD14/FCGR3A/FCER1G/CR1/MRC1/CALM2/FCGR2A/FCGR1A/SYK/ATP6V0B/CD74/CD209/ATP6V0C/CLEC7A/CALM1/CALM3/CTSD/TLR1/HLA-DRA/TNFRSF1A/TLR4/CTSS/LAMP1/ITGB2/TLR2/RAB5C/CORO1A/CYCS/HSPD1/BAX/ITGAM/LSP1/ATP6AP1/BID/HLA-DMB/HLA-DPA1/PPP3R1/CALML4/HLA-DMA/FCGR2B/CAMK2D/IL10RA/IL1B/MAPK10/HLA-DQA2/AKT1/TGFB3/TNF/BAD/HSPA9/ITGAX/CREB1/ATP6V0D1/IRAK2/RFXANK/BCL10/CASP10	5.85776679066923
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	34/1479	87/9376	2.4774739067248	MT-CO2/COX6C/COX5B/UQCR10/COX4I1/UQCR11/RYR2/COX7C/UQCRB/COX6B1/MT-CYB/COX8A/ATP1B1/COX7B/COX7A2/UQCRQ/UQCRH/COX6A1/TPM3/ATP1B3/MT-CO1/MT-CO3/SLC8A1/COX4I2/COX5A/COX7A2L/UQCRFS1/CACNB4/CYC1/UQCRC1/MYL4/UQCRC2/CACNA2D4/COX7B2	5.99147319551513
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	36/1479	95/9376	2.40230596775915	CCL2/CCL3/CCL3L1/JUN/CD86/CXCL8/ATP6V1F/ATP6V1G1/CD28/ATP6V0B/ATP6V0C/ICAM1/MMP1/HLA-DRA/TLR4/ITGB2/TLR2/TNFRSF11A/ATP6V0E1/ANGPT1/CSF1/ATP6AP1/HLA-DMB/HLA-DPA1/TEK/HLA-DMA/ATP6V1B2/TNFSF13B/IL1B/HLA-DQA2/TGFB3/CXCL12/TNF/LTB/ATP6V1D/ATP6V0D1	5.94491780987763
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	46/1479	144/9376	2.02509202914882	RBPJ/SLC25A6/PSMA7/PSMB6/SLC25A5/PRKCB/PSMB3/PSMB1/PSMA2/PSMB4/PSMA1/PLCB1/SEM1/PSMA4/SLC1A6/PSMC5/CYCS/PSMD4/PSMD8/PSMC3/PSMB5/PSMC4/GRIN2C/PRKCA/PSMB2/PIK3R2/MAP3K5/RYR1/PIK3CD/VDAC3/ADRM1/VDAC2/VDAC1/PSMA3/PSMC2/PLCB2/MAPK10/AKT1/PSMD7/PSMA6/PSMD2/PSMD6/PSMD13/GTF2B/VLDLR/PSMD3	5.36456931215207
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	45/1479	142/9376	2.00897065965774	CCL2/CYBA/MEF2C/ACTB/JUN/CALM2/MMP2/SUMO2/ACTG1/VCAM1/GSTP1/KLF2/HSP90AB1/CALM1/GSTO1/ICAM1/CALM3/PECAM1/BMP4/MEF2A/TNFRSF1A/TXN2/RAC1/SUMO1/KDR/NCF1/MGST3/HSP90AA1/ACVR2A/SUMO3/HMOX1/MGST2/CDH5/PIK3R2/MAP3K5/PIK3CD/CALML4/NFE2L2/IL1B/MAPK10/AKT1/NCF2/TNF/RAC2/RAC3	5.24283790476293
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	61/1479	216/9376	1.79029875040693	CCL2/CD36/CD14/CCL3/CYBB/CYBA/LY96/CCL3L1/JUN/CALM2/CXCL8/HSPA1A/VCAM1/NCF4/PYCARD/HSP90AB1/CALM1/NLRP3/ICAM1/POU2F2/CALM3/MMP1/HSPA8/SOD2/TNFRSF1A/CASP1/TLR4/PLCB1/RAC1/TANK/TLR2/NCF1/CDC42/CYCS/VAV1/HSP90AA1/LYN/HSPD1/BAX/PRKCA/PIK3R2/BID/MAP3K5/PIK3CD/PPP3R1/CALML4/ATF6/CAMK2D/HSPA6/PLCB2/NFE2L2/IL1B/MAPK10/AKT1/TNFRSF10B/NCF2/TNF/BAD/HRAS/EIF2S1/VLDLR	5.08521231639314
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	67/1479	248/9376	1.71266548888743	CD14/TUBA1B/ACTB/S100A10/LY96/JUN/PFN1/PTPRC/CXCL8/DYNLL1/ARPC3/RPS3/ACTG1/BRK1/MYL12B/RHOG/PYCARD/MYL12A/DYNLRB1/ARPC1B/HSP90AB1/TUBB/NLRP3/ARPC5/CYTH4/NCKAP1L/TNFRSF1A/CASP1/TLR4/TXN2/RAC1/GAPDH/TUBA1A/ELMO1/TUBB2A/TLR2/DYNLT1/RAB5C/MAP2K2/ARF6/ACTR2/CDC42/CYCS/ARPC4/HSP90AA1/DCTN3/SNX18/BAX/M6PR/PIK3CD/DYNLT3/FLNA/KIF5B/IL1B/DCTN6/MAPK10/AKT1/TNFRSF10B/DYNLL2/RAB9A/TNF/PIK3CG/HRAS/LEF1/CYFIP1/PKN1/CYTH1	4.92223573826458
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	21/1479	50/9376	2.66255578093306	CCL2/CD36/HGF/HBB/CR1/HBA1/HBA2/CXCL8/CD81/VCAM1/ICAM1/PECAM1/GYPC/TLR4/ITGB2/TLR2/LRP1/KLRB1/IL1B/TGFB3/TNF	5.10096305635046
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	33/1479	98/9376	2.13470215672476	FCGR3A/MARCKS/PTPRC/FCGR2A/CFL1/ARPC3/FCGR1A/SYK/ARPC1B/BIN1/PRKCB/ARPC5/HCK/INPP5D/PLD1/RAC1/WAS/NCF1/ARF6/ACTR2/CDC42/ARPC4/VAV1/LYN/PLPP3/MARCKSL1/PRKCA/PIK3R2/WASF2/PIK3CD/FCGR2B/AKT1/RAC2	4.88659549497828
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	26/1479	70/9376	2.35464116681155	LAMA2/ACTB/CD86/HLA-C/CCND1/ACTG1/CD28/HLA-A/ICAM1/DTNA/HLA-DRA/RAC1/ITGB2/HLA-E/CYCS/BID/HLA-DMB/SGCE/HLA-DPA1/EIF4G3/HLA-DMA/SGCB/HLA-DQA2/RAC2/RAC3/PRF1	4.92300664010352
NA	NA	hsa04517	IgSF CAM signaling	75/1479	299/9376	1.59015514867001	NRP1/MTSS1/TUBA1B/ACTB/SLIT2/CADM3/CD86/PTPRD/MYL6/DYNLL1/ARPC3/ACTG1/EPB41L2/PMP22/CD28/UNC5C/MYL12B/LCP2/MYL12A/ARPC1B/CD209/ROBO1/TUBB/ROBO2/DOK2/ICAM1/PRKCB/ARPC5/NRP2/INPP5D/MAGI1/IL1RAPL1/NLGN4X/RAC1/MSN/ANK2/TUBA1A/EPB41L3/TUBB2A/ITGB2/KDR/MAP2K2/NRCAM/ARF6/ACTR2/CDC42/ARPC4/VAV1/LYN/LMO7/KIRREL1/NCAM2/ITGAM/PRKCA/PIK3R2/PIK3CD/CD84/MAG/MYL6B/SLIT3/ANK3/ICAM2/JAM3/LRFN5/ITGA4/MAPK10/AKT1/DYNLL2/TRPC6/ITGAX/DOK1/CASK/GRIP2/MBP/CD2AP	4.48816984005609
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	36/1479	116/9376	1.96740574945793	CYBB/CYBA/ACTB/GNAI2/MMP2/ACTG1/VCAM1/NCF4/MYL12B/MYL12A/CD99/ICAM1/PECAM1/PRKCB/RAC1/MSN/ITGB2/NCF1/CDC42/TXK/ARHGAP5/THY1/VAV1/CDH5/ITGAM/PRKCA/PIK3R2/PIK3CD/SIPA1/CLDN5/JAM3/ITGA4/NCF2/CXCL12/RAC2/GNAI3	4.53702133607622
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	33/1479	103/9376	2.03107583843715	CD14/COL3A1/LAMA2/COL1A1/COL1A2/CXCL8/HSPB1/PRKCB/GNAS/TLR4/PRDX1/PLCB1/GNA14/LAMA4/ITGB2/TLR2/SERPINB9/RAB5C/ITGAM/PRKCA/PIK3R2/PIK3CD/LAMB2/PLCB2/IL1B/LAMC3/GNA15/TGFB3/SERPINB6/TNF/PRKACA/C9/ARG2	4.55342039722572
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	20/1479	51/9376	2.48604648079651	ACTB/SEC61B/ATP6V1F/ACTG1/ATP6V1G1/ATP6V0B/SEC61G/ATP6V0C/GNAS/KDELR2/ATP6V0E1/KCNQ1/ATP6AP1/PRKCA/ATP6V1B2/KDELR3/PRKACA/ATP6V1D/ATP6V0D1/SEC61A1	4.60502208732514
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	32/1479	101/9376	2.00852864191084	CCL2/COL3A1/CYBB/COL1A1/COL1A2/JUN/MMP2/CXCL8/EGR1/CCND1/VCAM1/ICAM1/PRKCB/PLCB1/RAC1/VEGFB/CDC42/AGTR1/BAX/PRKCA/CDK4/PIK3R2/PIK3CD/PLCB2/IL1B/MAPK10/AKT1/TGFB3/CDKN1B/TNF/PIM1/HRAS	4.40991908061762
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	52/1479	196/9376	1.68188654772254	RPS27A/UBA52/GNG2/UBB/JUN/CALM2/CD86/CXCL8/GNG5/HLA-C/CDK6/GNG10/CCND1/SYK/GNG11/HLA-A/CALM1/HIF1A/ICAM1/CALM3/GNB2/HCK/CD200R1/CCR1/TNFRSF1A/RAC1/RB1/MAP2K2/HLA-E/CYCS/GNB4/GNGT1/PIK3R5/LYN/BAX/CDK4/PIK3R2/BID/PIK3CD/PPP3R1/CALML4/CLEC2B/PREX1/IRF9/MAPK10/AKT1/PIK3CG/ATG3/FGF2/HRAS/CREB1/LEF1	4.17500955759352
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	55/1479	212/9376	1.64466046665901	HGF/ACTB/GNAI2/PFN1/CALM2/IGF1/PDGFC/ACTG1/DOCK4/LCP2/CALM1/CALM3/PRKCB/FGF7/KITLG/MAGI1/FYB1/GNAS/MAGI3/PLCB1/RAC1/ITGB2/KDR/MAP2K2/VEGFB/ID1/EFNA5/CDC42/VAV1/ANGPT1/SIPA1L2/FPR1/CSF1/ITGAM/PRKCA/PIK3R2/RAPGEF5/PIK3CD/SIPA1/CALML4/ENAH/TEK/CSF1R/APBB1IP/FGF10/LPAR5/PLCB2/P2RY1/AKT1/RAC2/RAC3/FGF2/HRAS/GNAI3/PRKD1	4.10861156831579
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	58/1479	227/9376	1.61976332383174	CCL2/CCL3/CCL4/GNG2/CCL4L2/CCL3L1/GNAI2/CALM2/CXCL8/GNG5/HLA-C/CDK6/GNG10/CCND1/B2M/GNG11/HLA-A/CALM1/CALM3/PRKCB/GNB2/GNAS/CCR1/TNFRSF1A/CALR/PLCB1/RAC1/RB1/MAP2K2/HLA-E/CYCS/GNB4/GNGT1/EIF4EBP1/BAX/PRKCA/CDK4/PIK3R2/BID/PIK3CD/PPP3R1/CALML4/PTGER4/IL10RA/PLCB2/IL1B/AKT1/GNA13/CXCL12/TNF/RAC2/PRKACA/RAC3/CDKN2A/HRAS/CREB1/GNAI3/ATF6B	4.09063418237048
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	26/1479	78/9376	2.11313950867703	CD14/C1QA/C1QC/C1QB/LY96/JUN/GNAI2/CALM2/CXCL8/CFL1/PYCARD/CALM1/NLRP3/CALM3/C1R/CASP1/TLR4/ITGB2/C2/ITGAM/C4BPB/CALML4/IL1B/MAPK10/TNF/GNAI3	4.27209384298358
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	26/1479	78/9376	2.11313950867703	CYBB/FCGR3A/CYBA/CR1/JUN/FCGR2A/EEF1A1/FCGR1A/NCF4/PRKCB/HLA-DRA/TLR4/ITGB2/TLR2/NCF1/MARCKSL1/ITGAM/HLA-DMB/HLA-DPA1/HLA-DMA/ITGA4/IL1B/HLA-DQA2/NCF2/TGFB3/TNF	4.27209384298358
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	47/1479	174/9376	1.71237167082449	HSPA1A/SEC61B/KRTCAP2/TMEM258/SSR4/DAD1/SEC61G/HSP90AB1/SSR2/HSPA8/MAN1A1/UBXN1/CALR/ERP29/RBX1/OSTC/SEC62/SSR1/HSP90AA1/RPN1/TXNDC5/CKAP4/HERPUD1/RAD23A/BAX/VCP/MAP3K5/DNAJB11/ATF6/STUB1/SSR3/HSPA6/TRAM1/NFE2L2/RNF5/DNAJA2/MAPK10/STT3A/BAG1/UBE2D3/PRKN/UBE2J1/DERL2/ERO1B/EIF2S1/SEC61A1/ATF6B	4.10467528347831
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	14/1479	31/9376	2.86296320530437	SRP14/SEC61B/SEC61G/SPCS1/SRP9/SPCS2/SEC62/SEC11A/TMEM208/SRP19/SEC11C/BAG6/SPCS3/SEC61A1	4.49608100928679
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	45/1479	166/9376	1.71851707030964	MEF2C/PRKG1/GNAI2/CALM2/SLC25A6/ATP1B1/PDE3A/ATP2B1/GUCY1A2/ATP1B3/CALM1/SLC25A5/CALM3/PDE3B/SLC8A1/PPP1CA/GUCY1A1/MEF2A/PLCB1/ADRB1/GATA4/MAP2K2/GTF2I/PIK3R5/AGTR1/PPP1CC/IRS1/PPP3R1/VDAC3/VDAC2/CALML4/VDAC1/PLCB2/ADRB2/AKT1/GUCY1B1/GNA13/RGS2/TRPC6/BAD/PDE5A/PIK3CG/CREB1/GNAI3/ATF6B	4.042034123163
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	39/1479	138/9376	1.79157480083488	CCL2/ACTB/JUN/FCGR2A/CXCL8/ARPC3/ACTG1/LCP2/RHOG/PYCARD/ARPC1B/NLRP3/ARPC5/CD4/FYB1/CASP1/TLR4/RAC1/WAS/ELMO1/MAP2K2/ARF6/ACTR2/CDC42/ARPC4/VAV1/PIK3R2/WASF2/PIK3CD/ITGA4/IL1B/MAPK10/AKT1/TNF/RAC2/RAC3/SKAP2/PKN1/RPS6KA3	4.05397606977064
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	30/1479	97/9376	1.96064490495807	GNG2/PRKG1/GNAI2/CALM2/RYR2/GNG5/GNG10/GNG11/GUCY1A2/CALM1/CALM3/PRKCB/GNB2/GUCY1A1/GNAS/PLCB1/GNB4/GNGT1/KCNJ5/GRIN2C/PRKCA/RYR1/PER3/CALML4/CAMK2D/PLCB2/GUCY1B1/PRKACA/CREB1/GNAI3	4.11563469473138
NA	NA	hsa04518	Integrin signaling	42/1479	154/9376	1.72893232528121	SPP1/LAMA2/HGF/COL1A1/ACTB/CCND2/COL6A1/COL1A2/COL6A2/IGF1/PDGFC/CCND1/ACTG1/VCAM1/FREM1/ICAM1/RAC1/ITGB5/LAMA4/ITGB2/KDR/VEGFB/CDC42/FERMT3/ITGAM/VTN/PIK3R2/TNXB/PIK3CD/ITGA9/ICAM2/LAMB2/FLNA/ITGA4/LAMC3/AKT1/PARVB/RAC2/RAC3/ITGAX/ILK/COL6A6	3.94705944867888
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	39/1479	140/9376	1.76598087510866	SPP1/MEF2C/GNG2/RPS6/GNAI2/CALM2/RYR2/GNG5/GNG10/EGR1/CCND1/GNG11/KLF2/CALM1/CALM3/PDE3B/SLC8A1/GNB2/MEF2A/PLCB1/MAP2K2/GNB4/GNGT1/PIK3R5/AGTR1/RYR1/CALML4/APLN/APLNR/TFAM/PLCB2/AKT1/GNA13/PRKACA/NOTCH3/MYL4/PIK3CG/HRAS/GNAI3	3.95165151391062
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	20/1479	56/9376	2.26407804501111	CD14/CR1/EEF1G/CXCL8/HSPA1A/EEF1A1/PYCARD/HSPA8/CASP1/TLR4/ITGB2/TLR2/CYCS/HSPD1/RAB1B/VCP/ITGAM/HSPA6/IL1B/TNF	4.10580767226381
Organismal Systems	Endocrine system	hsa04924	Renin secretion	23/1479	69/9376	2.11313950867703	GNAI2/CALM2/PDE3A/GUCY1A2/CTSB/CALM1/CALM3/PDE3B/GUCY1A1/GNAS/PLCB1/ADRB1/AGTR1/PPP3R1/CALML4/PTGER4/PDE1C/PLCB2/ADRB2/GUCY1B1/PRKACA/CREB1/GNAI3	4.01613166271818
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	26/1479	82/9376	2.01005953264401	LGMN/HLA-C/HSPA1A/B2M/HLA-A/CTSB/CD74/HSP90AB1/CD4/HSPA8/HLA-DRA/CALR/CTSS/PSME1/HLA-E/HSP90AA1/IFI30/PSME2/HLA-DMB/HLA-DPA1/HLA-DMA/HSPA6/HLA-DQA2/TNF/CREB1/RFXANK	3.97549507755546
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	53/1479	214/9376	1.57004290597967	GNG2/ELOB/JUN/GNAI2/CALM2/GNG5/HLA-C/CFL1/GNG10/B2M/GNG11/HLA-A/BST2/CALM1/CALM3/PRKCB/CD4/GNB2/AP1S2/RNF7/TNFRSF1B/TNFRSF1A/CALR/TLR4/RAC1/TLR2/AP1B1/MAP2K2/RBX1/HLA-E/CYCS/ELOC/GNB4/GNGT1/BAX/PRKCA/PIK3R2/BID/PIK3CD/PPP3R1/CALML4/APOBEC3C/MAPK10/AP1S1/AKT1/TNF/RAC2/BAD/CD247/RAC3/CDK1/HRAS/GNAI3	3.65054700217505
Organismal Systems	Immune system	hsa04611	Platelet activation	35/1479	126/9376	1.76094959056419	COL3A1/FCER1G/COL1A1/ACTB/PRKG1/COL1A2/GNAI2/FCGR2A/ACTG1/VAMP8/SYK/GUCY1A2/MYL12B/LCP2/MYL12A/TBXAS1/PPP1CA/GUCY1A1/GNAS/PLCB1/PIK3R5/LYN/FERMT3/PPP1CC/PIK3R2/PIK3CD/APBB1IP/PLCB2/P2RY1/AKT1/GUCY1B1/GNA13/PRKACA/PIK3CG/GNAI3	3.72142225149604
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	48/1479	193/9376	1.57664294947924	CXCL14/CCL2/CCL3/CCL4/GNG2/CCL4L2/CCL3L1/GNAI2/CXCL8/GNG5/GNG10/GNG11/CCL8/DOCK2/PRKCB/GNB2/HCK/ARRB2/CCR1/PLCB1/RAC1/WAS/ELMO1/NCF1/CDC42/GNB4/GNGT1/VAV1/PIK3R5/LYN/CCL13/ARRB1/CX3CR1/CXCL16/PIK3R2/PIK3CD/PLCB2/PREX1/AKT1/CXCL12/GRK2/RAC2/BAD/PRKACA/RAC3/PIK3CG/HRAS/GNAI3	3.50293440477205
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	54/1479	224/9376	1.5282526803825	NRP1/CCND2/JUN/HLA-C/EGR1/SLC25A6/CCND1/TSPO/B2M/HLA-A/RAN/SPI1/ANAPC11/SLC25A5/ICAM1/CD4/RANBP1/HLA-DRA/TNFRSF1A/CALR/RB1/ITGB2/MAP2K2/ANAPC13/HLA-E/EGR2/BAX/MAP3K1/CDK4/PIK3R2/HLA-DMB/HLA-DPA1/CDC26/PIK3CD/PPP3R1/VDAC3/VDAC2/LTBR/VDAC1/HLA-DMA/FDPS/ANAPC15/MAPK10/GPS2/HLA-DQA2/AKT1/IL2RA/TGFB3/TNF/PRKACA/CDKN2A/HRAS/CREB1/ATF6B	3.46295118002295
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	16/1479	44/9376	2.30524310037495	CD86/HLA-C/CD28/HLA-A/HLA-DRA/ICA1/HLA-E/HSPD1/HLA-DMB/HLA-DPA1/HLA-DMA/IL1B/HLA-DQA2/GZMB/TNF/PRF1	3.7555109754973
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	14/1479	37/9376	2.3986989017415	HBB/HBA1/HBA2/VCAM1/ICAM1/PRKCB/IDO2/PLCB1/LAMA4/PRKCA/PLCB2/IL1B/IDO1/TNF	3.68904169988737
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	36/1479	137/9376	1.66583260538044	CTSC/TUBA1B/ACTB/JUN/CTSZ/ACTG1/CTSB/CTSD/TNFRSF1A/CTSS/TUBA1A/MAP2K2/PMAIP1/CTSH/BCL2A1/CYCS/BAX/PIK3R2/BID/MAP3K5/PIK3CD/CTSO/PARP1/ENDOG/MAPK10/AKT1/TNFRSF10B/GZMB/TNF/BAD/CTSF/HRAS/EIF2S1/PRF1/DAXX/CASP10	3.39743780170466
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	58/1479	250/9376	1.47074509803922	DAB2/FOLR2/WWP1/HLA-C/CLTA/ARPC3/HSPA1A/PSD3/AP2S1/HLA-A/SNX2/SNX6/ARPC1B/BIN1/CLTC/SNX3/ARPC5/AP2M1/RAB11A/HSPA8/CYTH4/CHMP2A/ARRB2/PLD1/VPS28/VPS29/EPS15/RAB5C/ARF6/ACTR2/HLA-E/CDC42/CAPZA2/ARF5/ARPC4/VPS35/ARRB1/CHMP5/CHMP1B/ACAP2/CAPZB/EPN1/HSPA6/CAPZA1/RAB8A/RAB31/ZFYVE16/KIF5B/IL2RA/GRK2/MVB12B/CHMP3/SPG21/HRAS/MVB12A/ARF3/SNX12/CYTH1	3.26478235549369
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	78/1479	362/9376	1.3659520580951	SPP1/LAMA2/HGF/GNG2/COL1A1/RPS6/CCND2/COL6A1/COL1A2/COL6A2/IGF1/AREG/GNG5/CDK6/GNG10/PDGFC/CCND1/LPAR6/SYK/GNG11/YWHAB/HSP90AB1/FGF7/GNB2/KITLG/MAGI1/TLR4/YWHAH/RAC1/ITGB5/LAMA4/TLR2/KDR/MAP2K2/VEGFB/EFNA5/GNB4/GNGT1/HSP90AA1/PIK3R5/EIF4EBP1/ANGPT1/PIK3AP1/BDNF/CSF1/VTN/PRKCA/CDK4/PIK3R2/IRS1/TNXB/PIK3CD/TEK/CSF1R/ITGA9/EIF4E/FGF10/LAMB2/LPAR5/ITGA4/LAMC3/SGK3/AKT1/IL2RA/CDKN1B/BAD/EIF4E2/PIK3CG/FGF2/COL6A6/HRAS/PCK2/CDC37/CREB1/ATF6B/G6PC3/PKN1/PPP2CB	3.07297026946313
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	28/1479	103/9376	1.72333707503758	CCL2/CCL3/C1QA/C1QC/C1QB/CCL3L1/JUN/GNAI2/CXCL8/GNAS/TNFRSF1A/CALR/TLR4/PLCB1/GNA14/TLR2/PIK3R2/PIK3CD/PLCB2/IL1B/MAPK10/AKT1/GNA15/TGFB3/TNF/CD247/GNAI3/PPP2CB	3.19438946075787
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	48/1479	204/9376	1.49162788847791	LUM/DCN/HGF/WNT2/COL1A1/RPS6/ACTB/GPC3/COL1A2/MMP2/IGF1/CD63/CCND1/ACTG1/HIF1A/PRKCB/PPP1CA/TWIST1/TLR4/PLAUR/RAC1/MSN/ITGB5/ANK2/TLR2/PLAU/KDR/MAP2K2/CDC42/DDX5/VAV1/VTN/PRKCA/PPP1CC/PIK3R2/PIK3CD/CAMK2D/ANK3/FLNA/AKT1/FZD2/TWIST2/TNF/PRKACA/HBEGF/FGF2/HRAS/HSPB2	3.07226184937578
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	48/1479	205/9376	1.48435165487558	RBPJ/CCND2/JUN/HLA-C/CDK6/VIM/CCND1/SYK/B2M/HLA-A/ICAM1/HLA-DRA/CALR/SEM1/RAC1/RB1/TLR2/HLA-E/PSMC5/CYCS/PSMD4/LYN/PSMD8/BAX/PSMC3/PSMC4/CDK4/PIK3R2/BID/HLA-DMB/HLA-DPA1/PIK3CD/ADRM1/HLA-DMA/PSMC2/IRF9/MAPK10/HLA-DQA2/AKT1/PSMD7/CDKN1B/PSMD2/TNF/PSMD6/CD247/PSMD13/BLNK/PSMD3	3.03436645034544
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	38/1479	154/9376	1.56427210382586	MEF2C/ACTB/JUN/GNAI2/CALM2/RYR2/MYL6/CCND1/ACTG1/GUCY1A2/CALM1/CALM3/PRKCB/PPP1CA/GUCY1A1/EEF2/GNAS/PLCB1/MAP2K2/TRPM2/PIK3R5/KCNJ5/PRKCA/PPP1CC/RYR1/CACNB4/PPP3R1/CALML4/MYL6B/CAMK2D/PLCB2/GUCY1B1/RGS2/PRKACA/PIK3CG/HRAS/GNAI3/CACNA2D4	3.05544899270661
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	28/1479	105/9376	1.69051160694163	CD14/CCL4/CCL4L2/LY96/EDA/CXCL8/SYK/VCAM1/ICAM1/PRKCB/TNFRSF1A/TLR4/PLAU/TNFRSF11A/UBE2I/BCL2A1/LYN/CCL13/CSNK2B/PARP1/LTBR/TNFSF13B/IL1B/CXCL12/TNF/LTB/BCL10/BLNK	3.07922198098914
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	32/1479	125/9376	1.62289114266396	FCER1G/GNAI2/ASAH1/PRKCB/CTSD/PLD1/SGMS1/TNFRSF1A/PLCB1/RAC1/MAP2K2/BAX/DEGS1/PRKCA/PIK3R2/BID/MAP3K5/PIK3CD/CERS2/SPTSSA/PLCB2/MAPK10/S1PR1/AKT1/GNA13/S1PR2/TNF/RAC2/RAC3/HRAS/GNAI3/PPP2CB	3.03397136532413
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	20/1479	68/9376	1.86453486059738	CD14/DUSP6/CCND1/FCGR1A/RUNX1T1/SPI1/RUNX1/MAP2K2/BCL2A1/EIF4EBP1/ITGAM/PIK3R2/PIK3CD/CSF1R/AKT1/CEBPA/BAD/PIM1/HRAS/LEF1	3.09633138750969
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	14/1479	42/9376	2.11313950867703	FTL/CYBB/SLC40A1/GPX4/FTH1/NCOA4/PCBP1/PRNP/HMOX1/SAT2/VDAC3/GCLM/VDAC2/PCBP2	3.12880862803854
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	35/1479	142/9376	1.56253273528936	TYROBP/FCGR3A/CYBA/JUN/FCGR2A/FCGR1A/SYK/JUNB/NCF4/LCP2/SPI1/LILRB5/TNFRSF1A/SIRPA/RAC1/SOCS3/NCF1/TNFRSF11A/CSF1/TEC1/PIK3R2/PIK3CD/PPP3R1/CSF1R/FCGR2B/LILRB2/IL1B/IRF9/MAPK10/AKT1/NCF2/TNF/CREB1/LILRB1/BLNK	2.92304629377968
Organismal Systems	Nervous system	hsa04730	Long-term depression	18/1479	60/9376	1.90182555780933	PRKG1/GNAI2/IGF1/GUCY1A2/PRKCB/GUCY1A1/GNAS/PLCB1/MAP2K2/LYN/PRKCA/RYR1/PLCB2/GUCY1B1/GNA13/HRAS/GNAI3/PPP2CB	3.03264853029021
Human Diseases	Immune disease	hsa05330	Allograft rejection	13/1479	39/9376	2.11313950867703	CD86/HLA-C/CD28/HLA-A/HLA-DRA/HLA-E/HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/GZMB/TNF/PRF1	3.01451103328061
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	38/1479	160/9376	1.50561189993239	CADM3/PTPRC/CD86/HLA-C/PTPRD/VCAN/VCAM1/CD28/HLA-A/CD99/ICAM1/PECAM1/SIGLEC1/CD4/NLGN4X/HLA-DRA/ALCAM/ITGB2/NRCAM/HLA-E/CD34/NCAM2/CDH5/ITGAM/HLA-DMB/HLA-DPA1/MAG/CLDN5/ITGA9/HLA-DMA/ICAM2/SDC3/JAM3/ITGA4/NEGR1/HLA-DQA2/NTNG1/LRRC4	2.79154543828227
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	32/1479	130/9376	1.5604722525615	COL3A1/GNG2/COL1A1/COL1A2/JUN/GNAI2/MMP2/GNG5/GNG10/GNG11/MMP1/GNB2/ARRB2/GNAS/PLCB1/MAP2K2/VEGFB/GNB4/GNGT1/ARRB1/PRKCA/PIK3R2/PIK3CD/PLCB2/MAPK10/AKT1/GNA15/PRKACA/HRAS/CREB1/GNAI3/ATF6B	2.78475828393214
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	28/1479	110/9376	1.61367017026246	CYBB/RPS6/ELOB/IGF1/LDHB/HIF1A/PRKCB/MKNK1/TLR4/GAPDH/MAP2K2/RBX1/ELOC/ENO1/EIF4EBP1/ANGPT1/HMOX1/PRKCA/PIK3R2/PIK3CD/TEK/LTBR/EIF4E/CAMK2D/AKT1/CDKN1B/EGLN2/EIF4E2	2.80171441192666
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	46/1479	203/9376	1.43651848373119	SPP1/LAMA2/HGF/COL1A1/ACTB/CCND2/COL6A1/COL1A2/JUN/COL6A2/IGF1/PDGFC/CCND1/ACTG1/MYL12B/MYL12A/PRKCB/PPP1CA/RAC1/ITGB5/LAMA4/KDR/VEGFB/CDC42/ARHGAP5/VAV1/VTN/PRKCA/PPP1CC/PIK3R2/TNXB/PIK3CD/ITGA9/LAMB2/FLNA/ITGA4/MAPK10/LAMC3/AKT1/PARVB/RAC2/BAD/RAC3/ILK/COL6A6/HRAS	2.72103179428051
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	16/1479	53/9376	1.91378672483958	CLTA/ATP1B1/AP2S1/ATP2B1/ATP1B3/CLTC/PRKCB/AP2M1/RAB11A/SLC8A1/GNAS/PLCB1/PRKCA/PLCB2/KL/PRKACA	2.88697879099205
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	40/1479	173/9376	1.46576150890893	CCL2/ACTB/CXCL8/CDK6/SLC25A6/ACTG1/PYCARD/SLC25A5/NLRP3/ICAM1/PRKCB/RAB11A/HLA-DRA/TNFRSF1A/CASP1/TLR4/SOCS3/MAP2K2/CYCS/BAX/PRKCA/CDK4/PIK3R2/BID/HLA-DMB/HLA-DPA1/PIK3CD/VDAC1/TLR7/HLA-DMA/IL33/FDPS/IL1B/IRF9/HLA-DQA2/AKT1/TNFRSF10B/TNF/KPNA2/EIF2S1	2.67584277428501
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	18/1479	63/9376	1.81126243600889	POLR2L/POLR2K/POLR2I/POLR2J/GTF2H5/RBX1/PCNA/RAD23A/POLR2E/POLE4/CCNH/POLR2F/POLD4/RPA3/POLR2G/XPA/RPA2/POLE3	2.79592486675435
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	16/1479	54/9376	1.87834622993514	LDHB/SRM/ADI1/MDH2/PHGDH/BCAT1/MDH1/GCLM/APIP/CISD1/SMS/TST/MAT2A/SDSL/MAT2B/LACC1	2.80121683889862
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	28/1479	112/9376	1.58485463150778	LAMA2/LY96/GNAI2/HSPA1A/HSPA8/HLA-DRA/TNFRSF1A/TLR4/LAMA4/TLR2/CYCS/PIK3R5/HLA-DMB/HLA-DPA1/HLA-DMA/HSPA6/IL10RA/LAMB2/ALOX5/MAPK10/LAMC3/HLA-DQA2/AKT1/TGFB3/TNF/BAD/PIK3CG/GNAI3	2.69461254783438
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	14/1479	45/9376	1.9722635414319	CD86/HLA-C/CD28/HLA-A/HLA-DRA/HLA-E/HLA-DMB/HLA-DPA1/HLA-DMA/IL1B/HLA-DQA2/GZMB/TNF/PRF1	2.82920761905464
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	32/1479	133/9376	1.52527363032327	GNG2/GNAI2/CALM2/GNG5/GNG10/GNG11/CALM1/CALM3/PRKCB/GNB2/ARRB2/PPP1CA/GNAS/PLCB1/COMT/GNB4/GNGT1/KCNJ5/ARRB1/PRKCA/PPP1CC/CALML4/CAMK2D/PLCB2/KIF5B/MAPK10/AKT1/PRKACA/CREB1/GNAI3/ATF6B/PPP2CB	2.6402411718302
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	23/1479	88/9376	1.65689347839449	F13A1/C1QA/C1QC/CR1/CFD/C1QB/A2M/C3AR1/PROS1/C1R/VSIG4/CD59/PLAUR/ITGB2/PLAU/C2/CLU/ITGAM/VTN/C4BPB/CFI/ITGAX/C9	2.67925369999566
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	19/1479	69/9376	1.74563698542885	FCER1G/SYK/LCP2/INPP5D/RAC1/MAP2K2/VAV1/ALOX5AP/LYN/PRKCA/PIK3R2/PIK3CD/ALOX5/MAPK10/AKT1/TNF/RAC2/RAC3/HRAS	2.69020754607264
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	25/1479	99/9376	1.60086326414927	C1QA/FCGR3A/C1QC/CFD/C1QB/FCGR2A/FCGR1A/C3AR1/KRT10/ICAM1/C1R/HLA-DRA/ITGB2/PTAFR/C2/KRT18/FPR1/ITGAM/HLA-DMB/HLA-DPA1/HLA-DMA/FCGR2B/CFI/HLA-DQA2/FPR2	2.60092678957321
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	44/1479	200/9376	1.39467207572684	TUBA1B/ACTB/JUN/FCGR2A/CXCL8/ARPC3/RPS3/ACTG1/BRK1/PYCARD/ARPC1B/TUBB/NLRP3/ARPC5/MYO5A/CYTH4/NCKAP1L/TNFRSF1A/CASP1/TLR4/TMBIM6/RAC1/GAPDH/TUBA1A/TUBB2A/ARF6/ACTR2/MYO1B/CDC42/CYCS/ARPC4/BAX/MYO1F/NCL/WASF2/CLDN5/LPAR5/IL1B/MAPK10/TNFRSF10B/GNA13/TNF/CYFIP1/CYTH1	2.44153723185145
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	23/1479	91/9376	1.6022706164694	JUN/CD81/SYK/LILRB5/PRKCB/INPP5D/RAC1/MAP2K2/VAV1/LYN/PIK3AP1/PIK3R2/PIK3CD/PPP3R1/FCGR2B/LILRB2/AKT1/RAC2/RAC3/HRAS/LILRB1/BCL10/BLNK	2.49838908386947
Human Diseases	Substance dependence	hsa05032	Morphine addiction	23/1479	91/9376	1.6022706164694	GNG2/GNAI2/GNG5/GNG10/PDE4D/PDE3A/PDE4B/GNG11/PRKCB/PDE3B/GNB2/ARRB2/GNAS/GNB4/GNGT1/KCNJ5/ARRB1/PRKCA/PDE1C/GABRA3/GRK2/PRKACA/GNAI3	2.49838908386947
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	35/1479	154/9376	1.44077693773434	GNAI2/CALM2/RYR2/ATP1B1/ATP2B1/TPM3/ATP1B3/CALM1/CREM/CALM3/SLC8A1/PPP1CA/GNAS/PLCB1/ADRB1/SCN1B/PIK3R5/KCNQ1/AGTR1/PRKCA/PPP1CC/CACNB4/CALML4/CAMK2D/PLCB2/ADRB2/AKT1/PRKACA/MYL4/PIK3CG/CREB1/GNAI3/ATF6B/CACNA2D4/PPP2CB	2.3867411507274
Genetic Information Processing	Transcription	hsa03040	Spliceosome	51/1479	243/9376	1.33049524620406	HSPA1A/SNRPF/SNRPD2/LSM3/SF3B5/SNRPG/HSPA8/SF3B6/HNRNPA1/LSM4/LSM7/HNRNPK/SNU13/BCAS2/SNRPD1/LSM5/PCBP1/SNRPE/HNRNPA3/BUD31/SRSF3/SNRPC/DDX5/MAGOH/SRSF9/RBM8A/SRSF10/CWC15/SNRPD3/SYF2/SNRPB2/SNRPB/LSM8/LSM6/PRPF31/HSPA6/LSM2/NCBP2/SF3B2/TXNL4A/PUF60/THOC6/ALYREF/CDC40/EIF4A3/PHF5A/SF3B4/SNRNP27/PQBP1/SRSF8/ISY1	2.25891703844227
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	22/1479	89/9376	1.56704727609758	TUBA1B/PRKG1/GNAI2/PDGFC/GJA1/GUCY1A2/TUBB/PRKCB/GUCY1A1/GNAS/PLCB1/ADRB1/TUBA1A/TUBB2A/MAP2K2/PRKCA/PLCB2/GUCY1B1/PRKACA/CDK1/HRAS/GNAI3	2.32602942998971
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	42/1479	195/9376	1.36541322099131	CYBB/FCGR3A/CYBA/CR1/ACTB/HDAC9/FCGR2A/SLC25A6/ACTG1/FCGR1A/SYK/HMGB1/NCF4/CLEC7A/SLC25A5/PRKCB/CASP1/TLR4/PLCB1/RAC1/CLCN5/ITGB2/TLR2/NCF1/MAP2K2/FPR1/ITGAM/PRKCA/PIK3R2/PIK3CD/VDAC3/VDAC2/HDAC8/VDAC1/TLR7/PLCB2/AKT1/NCF2/TLR8/RAC2/SIGLEC9/FPR2	2.23149143707746
Human Diseases	Infectious disease: viral	hsa05162	Measles	31/1479	136/9376	1.44501451696297	CCND2/RACK1/JUN/CDK6/HSPA1A/CCND1/CD28/CD209/HSPA8/TLR4/MSN/TLR2/CYCS/BAX/CDK4/PIK3R2/BID/PIK3CD/CSNK2B/TLR7/FCGR2B/HSPA6/IL1B/IRF9/MAPK10/AKT1/IL2RA/CDKN1B/RAB9A/BAD/EIF2S1	2.26227972472981
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	16/1479	60/9376	1.69051160694163	HSPB1/PRKCB/RAC1/KDR/MAP2K2/CDC42/PRKCA/PIK3R2/PIK3CD/PPP3R1/AKT1/RAC2/BAD/MAPKAPK3/RAC3/HRAS	2.32204442622661
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	21/1479	85/9376	1.5662092829018	ENPP1/NME2/APRT/GUK1/TYMP/NME3/HDDC2/NME1/NME4/DCK/IMPDH2/NT5C/DUT/ADA2/NUDT16/UCK1/LACC1/DCTPP1/DGUOK/ITPA/NME6	2.26931024752724
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	9/1479	28/9376	2.03767024051	ELOVL2/PPT1/ECHS1/HACD4/HACD3/HADHB/HADHA/ELOVL1/HSD17B12	2.37967518429981
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	9/1479	28/9376	2.03767024051	ATP6V1F/ATP6V1G1/ATP6V0C/ATP6V0E1/ATP6V1B2/SLC12A7/SLC4A1/ATP6V1D/ATP6V0D1	2.37967518429981
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	30/1479	133/9376	1.42994402842807	TYROBP/HCST/FCGR3A/FCER1G/HLA-C/SYK/HLA-A/LCP2/ICAM1/PRKCB/RAC1/ITGB2/MAP2K2/HLA-E/VAV1/PRKCA/PIK3R2/BID/PIK3CD/PPP3R1/SH3BP2/ICAM2/TNFRSF10B/GZMB/TNF/RAC2/CD247/RAC3/HRAS/PRF1	2.16107540890584
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	19/1479	76/9376	1.58485463150778	ACTB/GNAI2/CALM2/ATP1B1/ACTG1/ATP1B3/CALM1/CALM3/PRKCB/GNAS/PLCB1/KCNQ1/HRH2/PRKCA/CALML4/CAMK2D/PLCB2/PRKACA/GNAI3	2.21539877647655
Human Diseases	Cancer: specific types	hsa05214	Glioma	19/1479	76/9376	1.58485463150778	CALM2/IGF1/CDK6/CCND1/CALM1/CALM3/PRKCB/RB1/MAP2K2/BAX/PRKCA/CDK4/PIK3R2/PIK3CD/CALML4/CAMK2D/AKT1/CDKN2A/HRAS	2.21539877647655
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	13/1479	47/9376	1.75345618805116	LDHB/AKR1A1/ME1/MDH2/ACSS1/MDH1/GRHPR/ADH5/ALDH9A1/GLO1/HAGH/ME2/PCK2	2.24092872026898
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	49/1479	238/9376	1.30517440241817	HGF/GNG2/CALM2/IGF1/GNG5/GNG10/PDGFC/GNG11/RGL1/CALM1/CALM3/PRKCB/FGF7/GNB2/KITLG/PLD1/RAC1/RAB5C/KDR/MAP2K2/VEGFB/ARF6/EFNA5/CDC42/GNB4/GNGT1/ANGPT1/BDNF/CSF1/PRKCA/PIK3R2/RAPGEF5/PIK3CD/RASA3/CALML4/TEK/CSF1R/FGF10/REL/MAPK10/AKT1/PLAAT3/RASA2/RAC2/BAD/PRKACA/RAC3/FGF2/HRAS	2.0637147142185
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	14/1479	52/9376	1.70676652623914	CD36/PLTP/APOE/NPC2/TSPO/LRPAP1/LRP1/APOC1/VDAC3/VDAC2/VDAC1/LIPA/STARD3NL/VAPA	2.21164372709345
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	17/1479	67/9376	1.6085091782467	CALM2/CALM1/CALM3/PRKCB/PPP1CA/PLCB1/MAP2K2/GRIN2C/PRKCA/PPP1CC/PPP3R1/CALML4/CAMK2D/PLCB2/PRKACA/HRAS/RPS6KA3	2.16317510176476
Organismal Systems	Digestive system	hsa04970	Salivary secretion	22/1479	93/9376	1.49964739325467	CST3/PRKG1/CALM2/ATP1B1/ATP2B1/GUCY1A2/ATP1B3/CALM1/CALM3/PRKCB/GUCY1A1/LYZ/GNAS/PLCB1/ADRB1/PRKCA/CALML4/PLCB2/ADRB2/GUCY1B1/PRKACA/VAMP2	2.09555749646604
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	25/1479	109/9376	1.45399507477778	SPP1/CD14/CCL3/CCL4/CCL4L2/LY96/CCL3L1/JUN/CD86/CXCL8/TLR1/TLR4/RAC1/TLR2/MAP2K2/MAP3K8/PIK3R2/PIK3CD/TLR7/IL1B/IRF9/MAPK10/AKT1/TLR8/TNF	2.06316264043961
Human Diseases	Cancer: specific types	hsa05218	Melanoma	18/1479	73/9376	1.56314429408986	HGF/IGF1/CDK6/PDGFC/CCND1/FGF7/RB1/MAP2K2/BAX/CDK4/PIK3R2/PIK3CD/FGF10/AKT1/BAD/CDKN2A/FGF2/HRAS	2.0902982832341
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	18/1479	73/9376	1.56314429408986	HGF/CDK6/CCND1/RARB/PRKCB/RB1/MAP2K2/BAX/EML4/PRKCA/CDK4/PIK3R2/PIK3CD/KIF5B/AKT1/BAD/CDKN2A/HRAS	2.0902982832341
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	38/1479	180/9376	1.33832168882879	CCL2/HLA-C/SYK/B2M/HLA-A/CD74/BST2/POU2F2/PPP1CA/HLA-DRA/TNFRSF1A/CALR/SOCS3/TLR2/SRSF3/HLA-E/CYCS/EIF4EBP1/SRSF9/BAX/PPP1CC/PIK3R2/BID/HLA-DMB/HLA-DPA1/PIK3CD/HLA-DMA/IL1B/IRF9/HLA-DQA2/AKT1/ALYREF/TNF/BAD/EIF2S1/SRSF8/HCFC1/DAXX	1.98337697630705
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	24/1479	105/9376	1.44900994880711	FCER1G/JUN/CALM2/SYK/PYCARD/CD209/CLEC7A/CALM1/NLRP3/CALM3/CASP1/EGR2/LSP1/PIK3R2/PIK3CD/PPP3R1/CALML4/IL1B/IRF9/MAPK10/AKT1/TNF/HRAS/BCL10	2.00228539267196
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	23/1479	100/9376	1.45806626098715	CD36/CD14/CR1/FCGR1A/CD4/KITLG/HLA-DRA/CD59/CD34/CSF1/ITGAM/CD33/CD37/HLA-DMB/HLA-DPA1/CD9/CSF1R/HLA-DMA/ITGA4/IL1B/HLA-DQA2/IL2RA/TNF	1.99290497386052
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	7/1479	21/9376	2.11313950867703	ENPP1/DPYD/BCAT1/PPCS/AASDHPPT/PPCDC/VNN2	2.2099172153165
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	26/1479	116/9376	1.42090415238628	ESD/PGLS/GAPDH/ME1/TALDO1/TPI1/ENO1/MDH2/ECHS1/ACSS1/PHGDH/CAT/MDH1/TKT/ADH5/PGAM1/PGP/SUCLG1/IDH3B/GLUD1/ME2/SHMT2/HIBCH/SDHD/SDSL/SDHC	1.97399190659109
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	19/1479	80/9376	1.50561189993239	HGF/RPS6/IGF1/PDGFC/GAS6/PRKCB/KDR/MAP2K2/EIF4EBP1/BAX/PRKCA/PIK3R2/PIK3CD/EIF4E/AKT1/BAD/EIF4E2/FGF2/HRAS	1.9654087218809
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	18/1479	75/9376	1.52146044624746	CCND2/IGF1/CDK6/CCND1/EI24/PMAIP1/CYCS/BAX/CDK4/BID/SIVA1/ZMAT3/SESN3/TNFRSF10B/SHISA5/CD82/CDKN2A/CDK1	1.96212123374392
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	42/1479	205/9376	1.29880769801613	HDAC9/RBPJ/CCND2/JUN/HLA-C/CDK6/CCND1/SYK/YWHAB/HLA-A/HNRNPK/RANBP1/YWHAH/RAC1/RB1/PMAIP1/HLA-E/GTF2A2/CDC42/EGR2/LYN/BAX/CDK4/PIK3R2/PIK3CD/VDAC3/HDAC8/LTBR/IRF9/REL/CDKN1B/MRPS18B/RASA2/BAD/PRKACA/CDKN2A/CDK1/GTF2B/HRAS/CREB1/ATP6V0D1/ATF6B	1.87197059169337
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	17/1479	71/9376	1.51788894285252	JUN/CXCL8/ATP6V1F/ATP6V1G1/ATP6V0B/ATP6V0C/RAC1/CDC42/ATP6V0E1/LYN/ATP6AP1/ATP6V1B2/JAM3/MAPK10/HBEGF/ATP6V1D/ATP6V0D1	1.89559816913699
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	11/1479	41/9376	1.70081960454493	MMP2/CXCL8/CCND1/MMP1/RB1/MAP2K2/TYMP/CDK4/HBEGF/CDKN2A/HRAS	1.94616503440817
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	6/1479	18/9376	2.11313950867703	NEU1/FUCA1/FUCA2/HEXA/MAN2B1/MANBA	2.04565779807401
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	21/1479	93/9376	1.43148160265218	JUN/CALM2/MMP2/EGR1/CALM1/CALM3/PRKCB/PLD1/GNAS/PLCB1/MAP2K2/CDC42/PRKCA/MAP3K1/CALML4/CAMK2D/PLCB2/MAPK10/PRKACA/HBEGF/HRAS	1.80966521437268
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	26/1479	120/9376	1.37354068064007	JUN/CALM2/CALM1/CALM3/BEX3/ARHGDIB/RAC1/SH2B3/MAP2K2/CDC42/BAX/BDNF/MAP3K1/PIK3R2/IRS1/MAP3K5/ARHGDIA/PIK3CD/CALML4/CAMK2D/MAPK10/AKT1/BAD/HRAS/IRAK2/RPS6KA3	1.78219619468579
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	58/1479	300/9376	1.22562091503268	CD14/HGF/MEF2C/JUN/IGF1/AREG/DUSP6/HSPA1A/PDGFC/STMN1/HSPB1/PRKCB/FGF7/HSPA8/KITLG/ARRB2/MKNK1/TNFRSF1A/RAC1/KDR/MAP2K2/VEGFB/EFNA5/CDC42/ANGPT1/ARRB1/MAP3K8/BDNF/LAMTOR3/CSF1/PRKCA/MAP3K1/DUSP3/MAP3K5/CACNB4/PPP3R1/TEK/CSF1R/HSPA6/FGF10/FLNA/IL1B/MAPK10/AKT1/MAP3K20/TGFB3/RASA2/TNF/RAC2/DUSP9/PRKACA/MAPKAPK3/RAC3/FGF2/HRAS/DAXX/CACNA2D4/RPS6KA3	1.71882394873704
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	25/1479	115/9376	1.37813446218067	MEF2C/NACA/GNAI2/EGR1/PDE4D/PDE4B/NR4A2/PRKCB/ARRB2/PLD1/MEF2A/GNAS/PLCB1/MAFB/LRP6/ARRB1/PRKCA/PLCB2/KL/GNA13/PRKACA/HBEGF/CREB1/GNAI3/ATF6B	1.76565111856913
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	18/1479	78/9376	1.46294273677641	LSM3/LSM4/LSM7/BTG2/LSM5/ENO1/HSPD1/C1D/LSM8/LSM1/LSM6/PABPC4L/CNOT7/LSM2/NUDT16/EXOSC4/EXOSC8/HSPA9	1.77671783277821
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	18/1479	78/9376	1.46294273677641	ACTB/CLTA/ARPC3/ACTG1/RHOG/ARPC1B/CLTC/ARPC5/RAC1/ELMO1/ACTR2/CDC42/ARPC4/PIK3R2/WASF2/PIK3CD/ILK/CD2AP	1.77671783277821
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	29/1479	138/9376	1.33219664677465	RPS6/CALM2/CALM1/CALM3/PDE3B/PRKAR1A/PPP1CA/MKNK1/SOCS3/MAP2K2/FLOT1/EIF4EBP1/PPP1CC/PIK3R2/IRS1/PIK3CD/CALML4/EIF4E/PTPN1/PYGL/MAPK10/PHKG1/AKT1/BAD/PRKACA/EIF4E2/HRAS/PCK2/G6PC3	1.70131395676328
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	29/1479	139/9376	1.3226124982367	JUN/GNAI2/CALM2/MMP2/HSPA1A/KRT10/HSP90AB1/CALM1/CALM3/HSPA8/CTSD/GNAS/PLCB1/MAP2K2/KRT18/HSP90AA1/KCNJ5/PIK3R2/PIK3CD/CALML4/HSPA6/PLCB2/AKT1/PRKACA/HBEGF/HRAS/CREB1/GNAI3/ATF6B	1.65829492929914
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	6/1479	19/9376	2.0019216397993	HEXA/HYAL2/ARSB/GNS/NAGLU/GUSB	1.89182473163605
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	37/1479	184/9376	1.27477437751712	NRP1/EPHA3/SLIT2/GNAI2/CFL1/UNC5C/MYL12B/MYL12A/ROBO1/ROBO2/RAC1/EFNA5/CDC42/EFNB2/EPHA7/SEMA3B/PRKCA/PIK3R2/PIK3CD/PPP3R1/SEMA3G/ENAH/EPHA5/SLIT3/CAMK2D/ABLIM3/FES/TRPC6/CXCL12/RAC2/RAC3/ILK/NTNG1/LRRC4/HRAS/TRPC1/GNAI3	1.6289914037715
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	16/1479	69/9376	1.47001009299272	JUN/CALM2/CALM1/CALM3/PRKCB/PPP1CA/GNAS/GRIN2C/PRKCA/PPP1CC/PPP3R1/CALML4/CAMK2D/PRKACA/CREB1/ATF6B	1.6957644585885
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	34/1479	168/9376	1.28297755883963	FTL/CYBB/PPIA/SLC25A6/FTH1/HMGB1/PYCARD/HSP90AB1/SLC25A5/NLRP3/CHMP2A/TNFRSF1A/CASP1/TLR4/HSP90AA1/BAX/CHMP5/CHMP1B/BID/VDAC3/VDAC2/PARP1/VDAC1/CAMK2D/IL33/PYGL/IL1B/IRF9/MAPK10/TNFRSF10B/GLUD1/TNF/CHMP3/SHARPIN	1.60163163203775
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	14/1479	59/9376	1.50426880278704	ENPP1/NME2/DPYD/TYMP/NME3/HDDC2/NME1/NME4/DCK/NT5C/DUT/UCK1/DCTPP1/NME6	1.68146841976452
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	32/1479	157/9376	1.29211078237577	CD36/C1QA/C1QC/C1QB/STAB1/PROS1/GAS6/HIF1A/PECAM1/CALR/CASP1/SIRPA/RAC1/ITGB5/ELMO1/RAB5C/MAP2K2/BSG/HAVCR2/CD47/LRP1/UQCRFS1/CX3CR1/PLA2G15/CAMK2D/PTGER4/ALOX5/S1PR1/LIPA/RAB14/ARG2/CREB1	1.5973282141899
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/1479	44/9376	1.58485463150778	DYNLL1/RAB11A/ARHGDIB/GNAS/RAB5C/ARHGDIA/DCTN6/DYNLL2/PRKACA/VAMP2/CREB1	1.68277310722189
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	16/1479	70/9376	1.44900994880711	HGF/ELOB/JUN/HIF1A/RAC1/MAP2K2/RBX1/CDC42/ELOC/PIK3R2/PIK3CD/AKT1/TGFB3/EGLN2/BAD/HRAS	1.63178191657411
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	9/1479	34/9376	1.67808137453764	POLR2L/POLR2K/POLR2I/POLR2J/POLR2E/POLR2F/POLR2G/POLR3GL/POLR1D	1.71411517065829
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	45/1479	232/9376	1.22962859341121	TMSB4X/ACTB/PFN1/CFL1/ARPC3/PDGFC/ACTG1/BRK1/MYL12B/MYL12A/ARPC1B/ARPC5/FGF7/IQGAP2/PPP1CA/NCKAP1L/RAC1/MSN/ITGB5/ITGB2/MAP2K2/ACTR2/CDC42/ARPC4/VAV1/ITGAM/PPP1CC/PIK3R2/WASF2/PIK3CD/ENAH/ITGA9/FGF10/LPAR5/ITGA4/AKT1/GNA13/CXCL12/RAC2/RAC3/ITGAX/C9/FGF2/HRAS/CYFIP1	1.53264123368639
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	15/1479	65/9376	1.46294273677641	SPP1/KISS1/PRKCB/ARRB2/PLCB1/MAP2K2/KCNJ5/ARRB1/PRKCA/PIK3R2/PIK3CD/PLCB2/AKT1/HRAS/TRPC1	1.62078140678142
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	19/1479	87/9376	1.38447071258151	JUN/AREG/CCND1/RAC1/MAP2K2/PMAIP1/CYCS/BAX/PIK3R2/PIK3CD/MAPK10/AKT1/APPL1/TGFB3/RAC2/BAD/RAC3/HRAS/LEF1	1.5591111006482
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	8/1479	30/9376	1.69051160694163	FOLR2/ABCC4/SLC46A1/ABCC5/IL1B/SHMT2/TNF/ABCG2	1.63929599679531
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	17/1479	77/9376	1.3996118823705	CDK6/CCND1/PLD1/RAC1/RB1/CDC42/BAX/CDK4/PIK3R2/PIK3CD/MAPK10/AKT1/TGFB3/RAC2/BAD/RAC3/CDKN2A	1.52371691351824
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	23/1479	110/9376	1.32551478271559	BMP5/DCN/PITX2/BMP4/BAMBI/EMP3/RBX1/ID1/SMAD6/ID2/ID3/ACVR2A/SMAD5/FMOD/GDF6/ZFYVE16/NRROS/TGFB3/TNF/TGIF2/NBL1/FST/PPP2CB	1.48613946420012
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	21/1479	99/9376	1.34472514188539	JUN/MMP2/IGF1/CCND1/GNAS/RB1/MAP2K2/BAX/CDK4/PIK3R2/PIK3CD/MAPK10/AKT1/CDKN1B/BAD/PRKACA/HBEGF/NOTCH3/CDKN2A/HRAS/DLL4	1.4921944975927
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	39/1479	201/9376	1.23003643042395	CD14/MEF2C/MAF/CCND2/IGF1/CD86/CXCL8/DUSP6/FCGR1A/RUNX1T1/NR4A3/SPI1/RUNX1/PROM1/FLI1/BMP2K/LMO2/PLAU/TSPAN7/ID2/DDX5/PBX3/BCL2A1/ETV5/LYL1/BAX/ITGAM/HHEX/ETV1/CSF1R/KLF3/CDK14/REL/CEBPA/CDKN1B/GZMB/SPINT1/MLLT1/MEIS1	1.42669213890639
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	48/1479	253/9376	1.20273553063041	CD14/RPS27A/UBA52/UBB/ACTB/JUN/PFN1/CXCL8/ARPC3/ACTG1/MYL12B/PYCARD/MYL12A/ARPC1B/NLRP3/ARPC5/CYTH4/SEPTIN7/TNFRSF1A/CASP1/TLR4/PLCB1/RAC1/ELMO1/ARF6/RBX1/ACTR2/CDC42/CYCS/ARPC4/CAPNS1/BAX/PIK3R2/WASF2/PIK3CD/RRAGA/TIFA/VDAC1/PLCB2/IL1B/MAPK10/AKT1/UBE2D3/TNF/ILK/SHARPIN/BCL10/CYTH1	1.41468564741726
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	22/1479	105/9376	1.32825911973985	RPS27A/UBA52/UBB/TOMM7/GABARAP/JUN/FIS1/HIF1A/GABARAPL2/TOMM20/FKBP8/RAB5C/VCP/CSNK2B/USP15/MAPK10/FUNDC1/PHB2/PRKN/MTX1/HRAS/EIF2S1	1.46381709851336
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	21/1479	100/9376	1.33127789046653	CXCL14/CCL2/CCL3/CCL4/CCL4L2/CCL3L1/CXCL8/CCL8/TNFRSF1B/CCR1/TNFRSF1A/CCL13/CSF1/CX3CR1/CSF1R/LTBR/IL10RA/TNFRSF10B/IL2RA/CXCL12/TNF	1.44128789188271
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	26/1479	128/9376	1.28769438810007	ENPP1/NME2/PDE4D/PDE3A/PDE4B/GUCY1A2/APRT/PDE3B/GUK1/GUCY1A1/NME3/HDDC2/NME1/NME4/DCK/IMPDH2/NT5C/PDE1C/ADA2/NUDT16/GUCY1B1/PDE5A/LACC1/DGUOK/ITPA/NME6	1.41824454202817
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	14/1479	62/9376	1.43148160265218	IGF1/HSPA1A/HSPA8/SOD1/SOD2/CAT/PIK3R2/IRS1/PIK3CD/EIF4EBP2/HSPA6/AKT1/PRKACA/HRAS	1.47512446990754
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	9/1479	36/9376	1.58485463150778	SSBP1/PCNA/RNASEH2C/POLE4/POLD4/RPA3/MCM3/RPA2/POLE3	1.52147353299022
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	31/1479	157/9376	1.25173232042652	CCND2/CALM2/CXCL8/HLA-C/CDK6/SLC25A6/CCND1/HLA-A/CALM1/SLC25A5/CALM3/PPP1CA/RB1/GATA4/MAP2K2/HLA-E/EIF4EBP1/CDK4/PPP1CC/PIK3R2/PIK3CD/PPP3R1/VDAC3/VDAC2/CALML4/VDAC1/AKT1/TGFB3/CDKN2A/CDK1/HRAS	1.37652959801917
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	17/1479	79/9376	1.36417867015859	SYT1/CLTA/ATP6V1F/ATP6V1G1/AP2S1/ATP6V0B/ATP6V0C/CLTC/AP2M1/SLC1A6/ATP6V0E1/ATP6V1B2/NAPA/VAMP2/ATP6V1D/ATP6V0D1/STX2	1.4066799329489
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	19/1479	90/9376	1.33832168882879	IGF1/SOD2/EIF4EBP1/BAX/CAT/PIK3R2/IRS1/PIK3CD/ADIPOR1/EIF4E/KL/SESN3/AKT1/APPL1/PRKACA/EIF4E2/HRAS/CREB1/ATF6B	1.39564643733779
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	31/1479	158/9376	1.24380996396813	WNT2/RPS6/IGF1/ATP6V1F/ATP6V1G1/LAMTOR4/LAMTOR5/PRKCB/LAMTOR2/LAMTOR1/TNFRSF1A/MAP2K2/EIF4EBP1/LRP6/LAMTOR3/PRKCA/PIK3R2/IRS1/PIK3CD/RRAGA/EIF4E/ATP6V1B2/PRR5/AKT1/FZD2/TNF/EIF4E2/STRADB/HRAS/ATP6V1D/RPS6KA3	1.33752004094992
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	33/1479	170/9376	1.23059300799427	TUBA1B/ACTB/JUN/MYL6/ARPC3/CCND1/ACTG1/MYL12B/MYL12A/ARPC1B/RUNX1/ARPC5/MAGI1/RAC1/MSN/TUBA1A/WAS/RAB13/GATA4/ACTR2/CDC42/ARPC4/PCNA/MAP3K1/CDK4/MAP3K5/MYL6B/CLDN5/RAB8A/JAM3/MAPK10/PRKACA/PPP2CB	1.31302733104658
Human Diseases	Immune disease	hsa05310	Asthma	8/1479	32/9376	1.58485463150778	FCER1G/HLA-DRA/PRG2/HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/TNF	1.43415193738798
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1479	27/9376	1.64355295119325	ELOVL2/HACD4/SCP2/HACD3/ACAA1/ELOVL1/HSD17B12	1.44917970923919
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	16/1479	75/9376	1.3524092855533	GSTP1/GSTO1/PMAIP1/MGST3/CYCS/BAX/MGST2/PIK3R2/BID/MAP3K5/PIK3CD/AKT1/TOP2A/BAD/XPA/CDKN2A	1.32602529516594
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	13/1479	59/9376	1.3968210311594	PRKG1/GNAI2/PDE3B/GNAS/ADRB1/PIK3R2/IRS1/PIK3CD/ADRB2/AKT1/PLAAT3/PRKACA/GNAI3	1.32318721385328
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	29/1479	149/9376	1.23384655875773	FCER1G/CXCL8/PDGFC/LPAR6/SYK/CYTH4/KITLG/PLD1/GNAS/PLCB1/MAP2K2/ARF6/PIK3R5/AGTR1/PLPP3/PRKCA/PIK3R2/PTGFR/PIK3CD/LPAR5/PLCB2/AKT1/GNA13/AGPAT2/AGPAT3/PIK3CG/HRAS/AGPAT1/CYTH1	1.24518108071055
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	20/1479	98/9376	1.29375888286349	CALM2/ATP1B1/ATP2B1/ATP1B3/CALM1/NR4A2/CALM3/PRKCB/GNAS/PLCB1/KCNJ5/AGTR1/PRKCA/CALML4/CAMK2D/PLCB2/PRKACA/CREB1/ATF6B/PRKD1	1.2650727991511
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	23/1479	115/9376	1.26788370520622	GNG2/GNAI2/GNG5/GNG10/GNG11/PRKCB/GNB2/PLCB1/GNB4/GNGT1/PIK3R5/KCNQ1/PRKCA/PIK3R2/PIK3CD/CAMK2D/PLCB2/AKT1/PRKACA/PIK3CG/HRAS/CREB1/GNAI3	1.25084913185673
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	9/1479	38/9376	1.50144122984947	IGF1/ATP1B1/ATP1B3/PRKCB/NR3C2/PRKCA/PIK3R2/IRS1/PIK3CD	1.34036648379815
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	12/1479	54/9376	1.40875967245136	CD86/HLA-C/CD28/HLA-A/HLA-DRA/HLA-E/HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/GZMB/PRF1	1.30361404023784
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	19/1479	93/9376	1.29515002144721	ACTB/ACTG1/PTPRJ/MYL12B/MYL12A/RAC1/WAS/CDC42/LMO7/ACP1/CDH5/WASF2/CSNK2B/PTPN1/RAC2/RAC3/PTPRB/LEF1/ARHGAP29	1.23788065018598
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	23/1479	116/9376	1.25695367326479	GNG2/GNAI2/GNG5/GNG10/GNG11/PRKCB/GNB2/PLD1/GNAS/PLCB1/SLC1A6/DLGAP1/GNB4/GNGT1/GRIN2C/PRKCA/PPP3R1/HOMER3/PLCB2/GRK2/PRKACA/TRPC1/GNAI3	1.20508307774555
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	20/1479	99/9376	1.28069061131941	CALM2/IGF1/HRH1/CALM1/CALM3/PRKCB/PPP1CA/GNAS/PLCB1/PRKCA/PPP1CC/PIK3R2/PIK3CD/CALML4/CAMK2D/PTGER4/PLCB2/IL1B/MAPK10/PRKACA	1.21501142459757
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	10/1479	44/9376	1.44077693773434	KRTCAP2/TMEM258/DAD1/MAN1A1/OSTC/HEXA/RPN1/MGAT4B/MGAT2/STT3A	1.26822553356681
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	21/1479	105/9376	1.26788370520622	LAMA2/ACTB/RYR2/IGF1/ACTG1/TPM3/SLC8A1/DTNA/GNAS/ITGB5/ADRB1/SGCE/CACNB4/ITGA9/ITGA4/SGCB/TGFB3/EMD/TNF/PRKACA/CACNA2D4	1.19458295143407
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	11/1479	50/9376	1.39467207572684	CD86/CD28/HLA-DRA/HLA-DMB/HLA-DPA1/LTBR/HLA-DMA/TNFSF13B/ITGA4/HLA-DQA2/CXCL12	1.21091135752806
Organismal Systems	Digestive system	hsa04978	Mineral absorption	13/1479	61/9376	1.35102362030171	FTL/SLC40A1/ATOX1/ATP1B1/FTH1/ATP2B1/ATP1B3/SLC8A1/HMOX1/SLC39A4/SLC46A1/CYBRD1/MT1G	1.1902782152448
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	21/1479	106/9376	1.25592253817597	FOLR2/IGF1/PDGFC/CCND1/GSTP1/HSP90AB1/RB1/PLAU/MAP2K2/ETV5/HSP90AA1/PIK3R2/PIK3CD/SLC46A1/AKT1/CDKN1B/BAD/SPINT1/HRAS/CREB1/LEF1	1.1467275752547
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	18/1479	89/9376	1.28212958953438	SPP1/CD36/LAMA2/COL1A1/COL6A1/COL1A2/COL6A2/FREM1/ITGB5/LAMA4/CD47/VTN/TNXB/ITGA9/LAMB2/ITGA4/LAMC3/COL6A6	1.15729632429265
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	12/1479	56/9376	1.35844682700666	KRTCAP2/TMEM258/ST6GAL1/DAD1/MAN1A1/OSTC/RPN1/MGAT4B/DPM2/MGAT2/STT3A/DPM3	1.16425859798052
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	20/1479	101/9376	1.25533040119428	WNT2/GNAI2/CALM2/CALM1/CALM3/PRKCB/KITLG/GNAS/PLCB1/MAP2K2/PRKCA/CALML4/CAMK2D/PLCB2/FZD2/PRKACA/HRAS/CREB1/GNAI3/LEF1	1.11646448231258
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	21/1479	107/9376	1.24418494436124	CALM2/LDHB/CALM1/CALM3/PDE3B/GNAS/PLCB1/PRMT1/PPP3R1/CALML4/PGAM1/CAMK2D/PLCB2/PYGL/PHKG1/AKT1/PPP4C/PRKACA/PCK2/CREB1/G6PC3	1.09934242237434
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	11/1479	51/9376	1.36732556443808	ENPP2/PLD1/PLPP3/PLD3/LPCAT2/PLD4/CEPT1/PLAAT3/TMEM86A/PAFAH1B3/PLB1	1.13828359969594
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	12/1479	57/9376	1.33461442653286	ELOVL2/PPT1/ECHS1/HACD4/SCP2/HACD3/HADHB/ACAA1/HADHA/ELOVL1/HSD17B12/CBR4	1.09656931587515
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	7/1479	30/9376	1.47919765607392	MDH2/MDH1/SUCLG1/IDH3B/SDHD/PCK2/SDHC	1.13763011566884
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	31/1479	169/9376	1.16285191897612	RPS27A/UBA52/UBB/GABARAP/VAMP8/HMGB1/CTSB/HIF1A/GABARAPL2/CTSD/TANK/LAMP1/MAP2K2/WDFY3/PIK3R2/IRS1/PIK3CD/RRAGA/RAB8A/C9orf72/MAPK10/AKT1/STX7/VMP1/BAD/PRKACA/ATG3/HRAS/EIF2S1/PPP2CB/RAB33B	0.924518950015265
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	23/1479	122/9376	1.19513627949767	SLC16A10/ACTB/CCND1/ATP1B1/ACTG1/ATP1B3/HIF1A/PRKCB/BMP4/PLCB1/GATA4/MAP2K2/PRKCA/PIK3R2/PIK3CD/PLCB2/AKT1/THRA/BAD/PRKACA/NOTCH3/PFKFB2/HRAS	0.938840561138178
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	34/1479	187/9376	1.15262155018747	CCL2/CYBB/CYBA/GABARAP/JUN/CXCL8/IFI16/CTSB/PYCARD/HSP90AB1/NLRP3/GABARAPL2/CASP1/TLR4/PLCB1/TXN2/NAMPT/GPSM3/TANK/CARD16/TRPM2/HSP90AA1/VDAC3/VDAC2/VDAC1/PLCB2/IL1B/IRF9/MAPK10/TRIP6/TNF/SHARPIN/NLRP1/PKN1	0.912307392700166
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/1479	31/9376	1.43148160265218	MDH2/ACSS1/CAT/MDH1/GRHPR/PGP/SHMT2	1.04133899908354
NA	NA	hsa04981	Folate transport and metabolism	7/1479	31/9376	1.43148160265218	FOLR2/SLCO2B1/ABCC4/SLC46A1/ABCC5/SHMT2/ABCG2	1.04133899908354
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	9/1479	42/9376	1.35844682700666	IDO2/ECHS1/CAT/ALDH9A1/INMT/HAAO/IDO1/KYNU/HADHA	1.00752108454439
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	19/1479	99/9376	1.21665608075344	JUN/PDGFC/HIF1A/PRKCB/PLD1/RAC1/WAS/MAP2K2/EIF4EBP1/PLPP3/PRKCA/PIK3R2/WASF2/PIK3CD/MAPK10/AKT1/RAC2/RAC3/HRAS	0.93782835160244
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/1479	59/9376	1.28937325953175	HPGDS/GPX4/LAP3/GSTP1/GSTO1/SRM/MGST3/MGST2/GCLM/GSTK1/GGCT/SMS	0.964906007942047
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	16/1479	82/9376	1.23695971239631	NME2/GSTP1/GSTO1/DPYD/MGST3/TYMP/NME3/MGST2/NME1/NME4/IMPDH2/DUT/GUSB/UCK1/ITPA/NME6	0.932650145625143
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	45/1479	254/9376	1.12312532941496	HGF/CALM2/RYR2/SLC25A6/PDGFC/ATP2B1/HRH1/CALM1/SLC25A5/CALM3/PRKCB/SLC8A1/FGF7/GNAS/PLCB1/GNA14/ADRB1/KDR/VEGFB/PTAFR/AGTR1/GRIN2C/HRH2/PRKCA/PTGFR/RYR1/PPP3R1/VDAC3/CYSLTR1/VDAC2/CALML4/VDAC1/CAMK2D/CYSLTR2/FGF10/PDE1C/PLCB2/ADRB2/PHKG1/MCOLN1/GNA15/ORAI3/MCOLN2/PRKACA/FGF2	0.860910264723041
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	15/1479	77/9376	1.23495166091515	CDK6/CCND1/RUNX1/RB1/MAP2K2/BAX/CDK4/PIK3R2/PIK3CD/AKT1/TGFB3/CDKN1B/BAD/CDKN2A/HRAS	0.895868805181559
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	7/1479	32/9376	1.3867478025693	LDHB/ACSS3/ECHS1/ACSS1/SUCLG1/HIBCH/HADHA	0.948364055706274
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	13/1479	66/9376	1.24867334603643	MAF/JUN/IL12RB2/HLA-DRA/TLR4/TLR2/HLA-DMB/HLA-DPA1/HLA-DMA/IL1B/HLA-DQA2/TGFB3/TNF	0.877334123844091
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1479	16/9376	1.58485463150778	HEXA/NAGA/GLA/FUT9	1.01323143854944
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	14/1479	73/9376	1.21577889540322	PPIA/RAN/BST2/CD4/BICD1/SUPT4H1/FEZ1/FURIN/SERINC5/PIN1/APOBEC3C/PSIP1/MLLT1/MDFIC	0.800935496200801
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	19/1479	103/9376	1.16940730091836	COL3A1/COL15A1/COL1A1/COL14A1/SLC16A10/COL6A1/COL1A2/COL6A2/ATP1B1/ATP1B3/COL5A2/SLC8A1/KCNQ1/ELN/COL8A2/KCNE3/COL21A1/COL6A6/SLC7A7	0.74813377511574
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	38/1479	217/9376	1.1101285898119	JUN/GNAI2/CCND1/HSP90AB1/GSTO1/PRKCB/FGF7/ARRB2/GNAS/ADRB1/RB1/MAP2K2/PTGES3/MGST3/HSP90AA1/EIF4EBP1/ARRB1/MGST2/KLF4/PRKCA/PIK3R2/PIK3CD/AIP/FGF10/ADRB2/AKT1/PAQR8/KPNB1/BAD/PRKACA/KPNA2/FGF2/HRAS/CREB1/GNAI3/ATF6B/DLL4/RPS6KA3	0.710304509301884
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	20/1479	109/9376	1.16319605982222	CD36/PRKCB/PPP1CA/TNFRSF1A/SOCS3/SLC27A4/PPP1CC/PIK3R2/IRS1/PIK3CD/PTPN1/PYGL/MAPK10/AKT1/TNF/PTPA/PCK2/CREB1/G6PC3/RPS6KA3	0.741638031771517
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	24/1479	133/9376	1.14395522274245	CCND2/GABARAP/IGF1/CCND1/KLF2/GABARAPL2/SOD2/MAP2K2/PRMT1/CAT/PIK3R2/IRS1/PIK3CD/HOMER3/MAPK10/S1PR1/SGK3/AKT1/TGFB3/CDKN1B/CDKN2D/HRAS/PCK2/G6PC3	0.723578120132745
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	16/1479	86/9376	1.17942670251741	LAMA2/ACTB/RYR2/ACTG1/GJA1/SLC8A1/DTNA/ITGB5/SGCE/CACNB4/ITGA9/ITGA4/SGCB/EMD/LEF1/CACNA2D4	0.723381005026408
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	22/1479	122/9376	1.14317383256299	GNAI2/IGF1/JUNB/PRKCB/GNAS/PLCB1/SOCS3/MAP2K2/PRKCA/MAP3K1/PIK3R2/IRS1/PIK3CD/PLCB2/SSTR1/MAPK10/AKT1/PRKACA/HRAS/CREB1/GNAI3/ATF6B	0.68883859859255
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	14/1479	75/9376	1.18335812485914	GAPDH/TALDO1/TPI1/ENO1/PHGDH/BCAT1/TKT/PGAM1/IDH3B/SHMT2/ARG2/MAT2A/SDSL/MAT2B	0.689929356587963
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/1479	12/9376	1.58485463150778	CD209/NCAM2/FCGR2B	0.877296729153938
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	5/1479	23/9376	1.37813446218067	ICMT/PMVK/FDPS/IDI1/GGPS1	0.785730056752389
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	5/1479	23/9376	1.37813446218067	SSBP1/PCNA/POLD4/RPA3/RPA2	0.785730056752389
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/1479	23/9376	1.37813446218067	ATP1B1/ATP1B3/MDH1/GLUD1/PCK2	0.785730056752389
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	18/1479	99/9376	1.15262155018747	LAMA2/ACTB/RYR2/IGF1/ACTG1/TPM3/SLC8A1/DTNA/ITGB5/SGCE/CACNB4/ITGA9/ITGA4/SGCB/TGFB3/EMD/TNF/CACNA2D4	0.660645278607311
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	39/1479	226/9376	1.09397045360714	JUN/GNAI2/CALM2/RYR2/PDE4D/ATP1B1/PDE3A/PDE4B/ATP2B1/ATP1B3/CALM1/CALM3/PDE3B/PPP1CA/PLD1/GNAS/RAC1/ADRB1/MAP2K2/VAV1/ABCC4/GRIN2C/BDNF/PPP1CC/PIK3R2/PIK3CD/CALML4/FXYD1/CAMK2D/SSTR1/ADRB2/MAPK10/AKT1/RAC2/BAD/PRKACA/RAC3/CREB1/GNAI3	0.618833266567404
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	25/1479	142/9376	1.11609481092097	RPS27A/UBA52/UBB/ELOB/WWP1/ANAPC11/PIAS2/RNF7/SOCS3/RBX1/ANAPC13/UBE2I/ELOC/UBE2M/MAP3K1/CDC34/UBE2B/CDC26/STUB1/ANAPC15/UBE2E3/UBE2D3/PRKN/UBE2J1/FANCL	0.603254682796433
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	8/1479	41/9376	1.23695971239631	GATM/PHGDH/GRHPR/PGAM1/GAMT/PIPOX/SHMT2/SDSL	0.658033399520225
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	56/1479	333/9376	1.066088400774	SPP1/LAMA2/WNT2/COL1A1/RBPJ/CCND2/COL6A1/COL1A2/COL6A2/HLA-C/CDK6/CCND1/ATP6V1F/ATP6V1G1/HLA-A/ATP6V0B/ATP6V0C/MAGI1/GNAS/TNFRSF1A/ITGB5/RB1/LAMA4/MAP2K2/HLA-E/CDC42/ATP6V0E1/EIF4EBP1/BAX/ATP6AP1/VTN/CDK4/PIK3R2/TNXB/PIK3CD/ITGA9/ATP6V1B2/PTGER4/LAMB2/ITGA4/IRF9/LAMC3/AKT1/FZD2/CDKN1B/TNF/BAD/PRKACA/RFNG/NOTCH3/COL6A6/HRAS/ATP6V1D/CREB1/ATP6V0D1/PPP2CB	0.53141003388838
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	21/1479	119/9376	1.11872091635843	CCL2/JUN/VCAM1/JUNB/ICAM1/TNFRSF1B/TNFRSF1A/SOCS3/MAP3K8/CSF1/PIK3R2/MAP3K5/PIK3CD/IL1B/MAPK10/AKT1/RHBDF2/TNF/CREB1/ATF6B/CASP10	0.564032650674856
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	16/1479	89/9376	1.13967074625278	GNG2/GABARAP/GNAI2/GNG5/GNG10/GNG11/PRKCB/GABARAPL2/GNB2/GNB4/GNGT1/PRKCA/GABRA3/SLC12A5/PRKACA/GNAI3	0.572929771444124
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	15/1479	83/9376	1.14567804687309	PRDX5/HMGCLL1/SOD1/SOD2/PRDX1/CAT/ECH1/PMVK/SCP2/GSTK1/NUDT19/PIPOX/ACAA1/MPV17/PXMP2	0.576891106719764
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	15/1479	83/9376	1.14567804687309	CCL4/CCL4L2/IFI16/POLR2L/PYCARD/POLR2K/NLRP3/CASP1/PCBP1/POLR2E/POLR2F/IL33/IL1B/POLR3GL/POLR1D	0.576891106719764
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	28/1479	163/9376	1.08897986950228	JUN/CXCL8/YWHAB/PRKCB/TLR4/RB1/TLR2/MAP2K2/CYCS/EGR2/PCNA/BAX/ATP6AP1/PRKCA/MAP3K1/PIK3R2/BID/PIK3CD/VDAC3/MAPK10/AKT1/TGFB3/TNF/BAD/HRAS/CREB1/ATF6B/CASP10	0.49593377598695
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	9/1479	48/9376	1.18864097363083	HMGCLL1/ECHS1/BCAT1/ALDH9A1/HSD17B10/HADHB/ACAA1/HIBCH/HADHA	0.567023470061405
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	9/1479	48/9376	1.18864097363083	ATP1B1/ATP1B3/PRKCB/PLCB1/PIK3R2/PIK3CD/PLCB2/AKT1/G6PC3	0.567023470061405
Cellular Processes	Cell motility	hsa04814	Motor proteins	33/1479	194/9376	1.07835469772694	TUBA1B/ACTB/MYL6/DYNLL1/ACTG1/MYL12B/TPM3/MYL12A/DYNLRB1/TUBB/MYO5A/TNNT3/KIF1B/TUBA1A/TUBB2A/DYNLT1/MYO1B/CAPZA2/DCTN3/MYO7A/MYO1F/DYNLT3/CAPZB/DNAH8/MYL6B/TNNT1/CAPZA1/KIF5B/DCTN6/DYNLL2/MYL4/CENPE/KIF20B	0.477238988431308
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	29/1479	170/9376	1.08143021914648	HGF/WNT2/ACTB/CDK6/CCND1/ACTG1/GSTP1/GSTO1/PRKCB/RB1/MAP2K2/MGST3/LRP6/BAX/HMOX1/MGST2/PRKCA/CDK4/PIK3R2/PIK3CD/NFE2L2/AKT1/FZD2/TGFB3/BAD/CDKN2A/HRAS/LEF1/BRD7	0.463674524403183
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/1479	31/9376	1.22698423084473	DPYD/ECHS1/ALDH9A1/CNDP2/HIBCH/HADHA	0.547804426197362
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	23/1479	134/9376	1.08810914999041	PRKG1/CALM2/MYL6/GUCY1A2/CALM1/CALM3/PRKCB/PPP1CA/GUCY1A1/GNAS/PLCB1/MAP2K2/RAMP2/AGTR1/PPP1R14A/PRKCA/PPP1CC/CALML4/MYL6B/PLCB2/GUCY1B1/GNA13/PRKACA	0.444558670325597
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/1479	37/9376	1.19934945087075	CCND1/TPM3/NCOA4/MAP2K2/BAX/HRAS/LEF1	0.525780377889907
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	9/1479	49/9376	1.16438299457714	JUN/GNAI2/GNAS/GRIN2C/BDNF/PRKACA/CREB1/GNAI3/ATF6B	0.499255198408749
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	21/1479	122/9376	1.0912113856283	JUN/PTPRC/CD28/LCP2/CD4/MAP2K2/CDC42/VAV1/MAP3K8/CDK4/TEC1/PIK3R2/PIK3CD/PPP3R1/MAPK10/AKT1/TNF/CD247/HRAS/BCL10/PPP2CB	0.438836636046923
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	15/1479	86/9376	1.10571253361008	JUN/AREG/PRKCB/MAP2K2/EIF4EBP1/PRKCA/PIK3R2/PIK3CD/CAMK2D/MAPK10/AKT1/CDKN1B/BAD/HBEGF/HRAS	0.42619319049974
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	9/1479	50/9376	1.1410953346856	LAP3/SRM/GATM/SAT2/ALDH9A1/GAMT/SMS/CNDP2/ARG2	0.432901017763577
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	8/1479	44/9376	1.15262155018747	HMGB1/PCNA/POLE4/POLD4/PARP1/APEX1/MPG/POLE3	0.439130386256642
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	6/1479	32/9376	1.18864097363083	TNFRSF1A/PMAIP1/CYCS/BAX/BID/MAPK10	0.462576174024563
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	16/1479	93/9376	1.09065264963976	MAF/RBPJ/JUN/IL12RB2/CD4/HLA-DRA/HLA-DMB/HLA-DPA1/PPP3R1/HLA-DMA/MAPK10/HLA-DQA2/IL2RA/CD247/NOTCH3/DLL4	0.380203803905929
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	16/1479	93/9376	1.09065264963976	LAMA2/CDK6/CCND1/RARB/RB1/LAMA4/CYCS/BAX/CKS1B/CDK4/PIK3R2/PIK3CD/LAMB2/LAMC3/AKT1/CDKN1B	0.380203803905929
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	11/1479	63/9376	1.10688259978321	PTGDS/HPGDS/GPX4/LTC4S/TBXAS1/PTGES3/ALOX5/PTGES2/PLAAT3/CBR1/PLB1	0.368358875368848
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/1479	33/9376	1.15262155018747	VAMP8/VAMP5/VAMP3/STX7/VAMP2/STX2	0.380074131786894
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	12/1479	70/9376	1.08675746160533	CD36/TNFRSF1B/TNFRSF1A/SOCS3/IRS1/ADIPOR1/MAPK10/AKT1/APPL1/TNF/PCK2/G6PC3	0.315292027162342
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	8/1479	46/9376	1.10250756974454	FTL/BLVRB/FTH1/HMOX1/BLVRA/UROD/FECH/GUSB	0.301600937746374
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	19/1479	115/9376	1.04738219125731	GNG2/GNAI2/GNG5/GNG10/GNG11/PRKCB/GNB2/GNAS/PLCB1/GNB4/GNGT1/KCNJ5/PRKCA/PLCB2/ALOX5/PRKACA/HRAS/TRPC1/GNAI3	0.221245158431915
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	15/1479	90/9376	1.05656975433852	JUN/CD28/HIF1A/CD4/TLR4/TLR2/MAP2K2/EML4/PIK3R2/PIK3CD/PPP3R1/CSNK2B/AKT1/CD247/HRAS	0.233361852670284
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	29/1479	178/9376	1.03282661379158	WNT2/SERPINF1/CCND2/JUN/PRICKLE1/CCND1/RSPO2/PRKCB/RSPO3/PLCB1/RAC1/BAMBI/RBX1/FRZB/LRP6/MCC/CACYBP/PRKCA/PPP3R1/CSNK2B/CAMK2D/PLCB2/MAPK10/FZD2/RAC2/PRKACA/RAC3/RUVBL1/LEF1	0.19134981223244
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/1479	59/9376	1.07447771627646	CCND1/MAP2K2/BAX/PIK3R2/PIK3CD/AKT1/BAD/ILK/HRAS/LEF1	0.248343596119574
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/1479	28/9376	1.13203902250555	AKR1B1/PCBD1/MOCS2/QDPR/CBR1	0.302803311639006
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1479	22/9376	1.15262155018747	HNMT/ALDH9A1/ASPA/CNDP2	0.310146706883292
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	18/1479	110/9376	1.03735939516873	GNAI2/IGF1/ANAPC11/HSP90AB1/PDE3B/ANAPC13/HSP90AA1/PIK3R2/CDC26/PIK3CD/ANAPC15/MAPK10/AKT1/CPEB4/PRKACA/CDK1/GNAI3/RPS6KA3	0.170564516473589
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1479	10/9376	1.26788370520622	SELENBP1/TST	0.366781883756949
Organismal Systems	Sensory system	hsa04744	Phototransduction	5/1479	29/9376	1.09300319414329	CALM2/CALM1/CALM3/GNGT1/CALML4	0.217069796052077
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/1479	67/9376	1.04080005651257	LDHB/AKR1A1/GAPDH/TPI1/ENO1/ACSS1/ADH5/ALDH9A1/PGAM1/PCK2/G6PC3	0.145039170408049
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	25/1479	156/9376	1.01593245609473	CD81/CDK6/CCND1/YWHAB/EIF3E/TNFRSF1A/YWHAH/SOCS3/RB1/MAP2K2/CYCS/BAX/CDK4/PIK3R2/BID/PIK3CD/CLDN5/IFIT1/IRF9/AKT1/TNF/BAD/HRAS/EIF2S1/PPP2CB	0.0868396821542542
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	37/1479	233/9376	1.00668877881181	DCN/COL3A1/LAMA2/COL1A1/ACTB/COL6A1/COL1A2/COL6A2/VIM/VCAN/ATP1B1/ACTG1/TPM3/ATP1B3/COL5A2/TNNT3/DTNA/ITGB5/ANK2/CAPZA2/ENO1/FBLN2/SGCE/CAPZB/ELN/ITGA9/TNNT1/ANK3/LBR/CAPZA1/SDC3/ITGA4/CSRP2/SGCB/EMD/MYL4/COL6A6	0.0447423809830282
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1479	17/9376	1.11872091635843	CD209/NRP2/LAMP1	0.212019415710209
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	5/1479	30/9376	1.05656975433852	PIGT/DPM2/GPAA1/PIGC/PIGP	0.134298353415896
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	9/1479	56/9376	1.018835120255	CCND2/DISP1/CCND1/ARRB2/GAS1/ARRB1/GLI2/GRK2/PRKACA	0.0611776951242792
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	12/1479	76/9376	1.00096081989965	CD36/PLTP/DBI/FABP5/MMP1/GK/ME1/SLC27A4/SCP2/ACAA1/ILK/PCK2	0.00363953556220676
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1479	18/9376	1.05656975433852	PRDX1/MMADHC/HCFC1	0.103960337581814
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1479	12/9376	1.05656975433852	VKORC1/GGCX	0.0848560612784733
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	10/1479	65/9376	0.975295157850939	AKR1A1/GK/AKR1B1/PLPP3/GLA/ALDH9A1/AGPAT2/AGPAT3/GPAT2/AGPAT1	-0.0864926601753933
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	21/1479	138/9376	0.964694123526472	CALM2/IGF1/YWHAB/ANAPC11/CALM1/CALM3/PPP1CA/YWHAH/RBX1/ANAPC13/PPP1CC/CDC26/PPP3R1/CALML4/CAMK2D/ANAPC15/CPEB4/PRKACA/CDK1/PPP2CB/RPS6KA3	-0.180815733642609
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	13/1479	86/9376	0.958284195795399	RYR2/ATP1B1/ATP1B3/PRKCB/GNAS/PLCB1/PRKCA/CAMK2D/PLCB2/PRKACA/VAMP2/CREB1/ATF6B	-0.168182438553594
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/1479	34/9376	0.932267430298691	BHLHE41/RBX1/PER3/NR1D2/CREB1	-0.171220490095083
NA	NA	hsa04081	Hormone signaling	33/1479	219/9376	0.955254846388248	GNG2/SLC16A10/SLC40A1/PRKG1/GNAI2/IGF1/GNG5/GNG10/GNG11/GNB2/GUCA2A/GNAS/PLCB1/GNA14/ADRB1/RAMP2/GNB4/GNGT1/SMAD5/AGTR1/PIK3R2/IRS1/PIK3CD/ADIPOR1/PLCB2/SSTR1/ADRB2/GNA15/THRA/GNA13/APPL1/PRKACA/GNAI3	-0.289954671345301
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	23/1479	154/9376	0.946796273368281	NME2/AKR1A1/IDO2/NME3/VKORC1/BCAT1/NME1/PPCS/MOCS2/NME4/GCLM/GGCX/UROD/HAAO/IDO1/FECH/KYNU/SHMT2/MAT2A/GUSB/PPCDC/MAT2B/NME6	-0.28809021718942
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	16/1479	108/9376	0.939173114967571	SUMO2/EEF1A1/RAN/SAP18/SUMO1/UBE2I/MAGOH/SUMO3/RBM8A/NCBP2/THOC6/ALYREF/EIF4A3/KPNB1/PNN/KPNA2	-0.275139597758882
NA	NA	hsa03272	Virion - Hepatitis viruses	7/1479	48/9376	0.924498535046202	CD63/CD81/LAMP1/CHMP1B/CD9/CLDN5/TGOLN2	-0.226944877503669
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	8/1479	55/9376	0.922097240149979	ASAH1/NEU1/SGMS1/HEXA/PLPP3/DEGS1/GLA/CERS2	-0.250750374653857
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	18/1479	122/9376	0.935324044824261	CD36/IGF1/CCND1/EEF2/EIF4EBP1/PIK3R2/IRS1/PIK3CD/ADIPOR1/RAB8A/AKT1/RAB14/STRADB/PFKFB2/PCK2/CREB1/G6PC3/PPP2CB	-0.311169251589961
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	16/1479	109/9376	0.930556847857776	JUN/RUNX1/HSP90AB1/HIF1A/CD4/HLA-DRA/HSP90AA1/HLA-DMB/HLA-DPA1/PPP3R1/HLA-DMA/IL1B/MAPK10/HLA-DQA2/IL2RA/CD247	-0.315581655162953
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1479	21/9376	0.905631218004443	CHSY3/B3GALT6/CSGALNACT2	-0.187350457238095
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	21/1479	143/9376	0.930963559766805	C1QA/FCGR3A/C1QC/C1QB/FCGR2A/CD86/FCGR1A/CD28/C1R/HLA-DRA/SNRPD1/SSB/C2/SNRPD3/SNRPB/HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/TNF/C9	-0.360009239278221
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/1479	36/9376	0.880474795282097	AKR1A1/AKR1B1/KL/DCXR/GUSB	-0.310939549259786
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/1479	43/9376	0.884570026888061	ECHS1/ADH5/ALDH9A1/HADHB/ACAA1/HADHA	-0.3283075313773
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/1479	29/9376	0.874402555314635	RASSF4/MOB1A/DCHS1/FAT4	-0.293144896297954
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	23/1479	158/9376	0.922826747460224	CCND2/CDK6/CCND1/YWHAB/ANAPC11/YWHAH/RB1/RBX1/ANAPC13/PCNA/CDKN1C/CDK4/CCNH/CDC26/HDAC8/ANAPC15/MCM3/TGFB3/CDKN1B/CDKN2A/CDK1/CDKN2D/PPP2CB	-0.423365682916609
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/1479	71/9376	0.892875848736775	CCND2/CCND1/SOCS3/MAP2K2/TNFRSF11A/PIK3R2/PIK3CD/MAPK10/AKT1/HRAS	-0.392100174771932
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	6/1479	44/9376	0.864466162640605	GTF2H5/TAF10/GTF2I/GTF2A2/CCNH/GTF2B	-0.389964761053523
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1479	23/9376	0.826880677308405	ATP6AP2/CTSA/AGTR1	-0.359726681506244
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	21/1479	148/9376	0.899512088153062	WNT2/JUN/IGF1/CDK6/CCND1/FGF7/RB1/MAP2K2/LRP6/BAX/CDK4/PIK3R2/PIK3CD/FGF10/AKT1/FZD2/NOTCH3/FGF2/HRAS/LEF1/DLL4	-0.533248377346511
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1479	31/9376	0.81798948722982	AKR1A1/ALDH9A1/KL/GUSB	-0.439264719574996
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	14/1479	102/9376	0.870116268278779	RYR2/ATP1B1/ATP2B1/ATP1B3/PRKCB/RAB11A/GNAS/PLCB1/RAC1/KCNQ1/PRKCA/PLCB2/RAB8A/TRPC1	-0.570768443898243
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	22/1479	157/9376	0.888326162883339	BMP5/WNT2/ACTB/CCND2/AREG/CCND1/ACTG1/YWHAB/BMP4/PPP1CA/YWHAH/ITGB2/ID1/ID2/MOB1A/PPP1CC/GDF6/FZD2/GLI2/TGFB3/LEF1/PPP2CB	-0.610657947517408
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/1479	75/9376	0.845255803470814	ATP1B1/ATP1B3/PRKCB/GNAS/PLCB1/PRKCA/PLCB2/PRKACA/CREB1/ATF6B	-0.582262520567991
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/1479	32/9376	0.792427315753888	AKR1B1/GAA/GLA/G6PC3	-0.508999589338857
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/1479	32/9376	0.792427315753888	GABARAP/GABARAPL2/ATG3/PPP2CB	-0.508999589338857
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	20/1479	144/9376	0.880474795282097	CD14/C1QA/C1QC/C1QB/LY96/CXCL8/CCND1/C3AR1/TNFRSF1A/TLR4/C2/MAP3K5/ADIPOR1/ADH5/ALDH9A1/IL1B/MAPK10/AKT1/TNF/LEF1	-0.625506029727662
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/1479	47/9376	0.809287471408226	SOCS3/PIK3R2/IRS1/PIK3CD/MAPK10/TNF	-0.567217031877916
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1479	17/9376	0.745813944238953	SEPHS2/INMT	-0.453941737287754
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1479	17/9376	0.745813944238953	CA8/GLUD1	-0.453941737287754
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	14/1479	104/9376	0.853383263119571	PLD1/SGMS1/PLPP3/PLA2G15/PLD3/LPCAT2/PLD4/CEPT1/PLAAT3/AGPAT2/AGPAT3/GPAT2/AGPAT1/PLB1	-0.650657086129769
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	13/1479	98/9376	0.840943273861269	CALM2/CALM1/CALM3/PRKCB/INPP5D/PLCB1/PRKCA/PIK3R2/PIK3CD/CALML4/PLCB2/MTMR6/PIP4P2	-0.684977883217378
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/1479	41/9376	0.773099820247695	SEM1/SSBP1/POLD4/RPA3/RPA2	-0.630098235367721
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1479	26/9376	0.731471368388204	PLAAT3/ACAA1/PLB1	-0.593348875290471
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/1479	49/9376	0.776255329718094	ST6GAL1/GXYLT2/GALNT1/B3GLCT/RFNG/C1GALT1C1	-0.6795452902038
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	21/1479	155/9376	0.858888961591311	WNT2/GNAI2/CDK6/CCND1/GNAS/PLCB1/RB1/MAP2K2/AGTR1/CDK4/AIP/CAMK2D/PLCB2/FZD2/CDKN1B/PRKACA/CDKN2A/CREB1/GNAI3/LEF1/ATF6B	-0.766613533807555
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	42/1479	298/9376	0.89347509427284	CXCL14/CCL2/BMP5/CCL3/CCL4/CCL4L2/EDA/CCL3L1/CXCL8/IL12RB2/CCL8/CD4/BMP4/TNFRSF1B/CCR1/TNFRSF1A/TNFRSF11A/ACVR2A/TNFSF12/CCL13/CSF1/CX3CR1/CXCL16/CSF1R/LTBR/IL33/IL10RA/TNFSF13B/GDF15/GDF6/IL1B/IL1RN/TNFRSF10B/IL2RA/TNFRSF12A/TGFB3/CXCL12/CNTFR/TNF/LTB/RELL1/TNFSF9	-0.808728703755888
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1479	27/9376	0.704379836225678	HMGCLL1/ECHS1/HADHA	-0.665689967219293
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1479	43/9376	0.737141689073384	CD36/SLC27A4/PLPP3/AGPAT2/AGPAT1	-0.747625255691911
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	19/1479	144/9376	0.836451055517993	WNT2/IGF1/BMP4/MAP2K2/ID1/ID2/ID3/ACVR2A/SMAD5/KLF4/PIK3R2/PIK3CD/PCGF5/AKT1/FZD2/DUSP9/FGF2/HRAS/MEIS1	-0.855893542876883
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1479	36/9376	0.704379836225678	ENPP1/GAA/PYGL/G6PC3	-0.769042819822287
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	13/1479	103/9376	0.800120784838877	SAP18/PPP1CA/MAGOH/RBM8A/PPP1CC/SSU72/PABPC4L/NCBP2/RNMT/ALYREF/EIF4A3/PNN/PPP2CB	-0.882703348645683
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1479	20/9376	0.63394185260311	LBR/LIPA	-0.709183503634175
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1479	52/9376	0.731471368388204	HSD17B2/IGF1/GNAS/HSD17B1/ALOX5/PRKACA	-0.840291159245234
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/1479	38/9376	0.667307213266432	PTPRC/CD4/RFXANK/BLNK	-0.889297158259094
NA	NA	hsa04082	Neuroactive ligand signaling	26/1479	199/9376	0.82826573706939	GNG2/GNAI2/GNG5/GNG10/GNG11/HRH1/TAC3/PRKCB/OGFRL1/GNB2/GNAS/PLCB1/ADRB1/SLC1A6/GNB4/GNGT1/GRIN2C/HRH2/PRKCA/PLCB2/P2RY1/GABRA3/ADRB2/PRKACA/P2RY13/GNAI3	-1.05967278082424
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	19/1479	150/9376	0.802993013297273	HGF/WNT2/CCND1/RARB/FGF7/RB1/MAP2K2/LRP6/BAX/PIK3R2/PIK3CD/FGF10/AKT1/FZD2/TGFB3/CDKN1B/FGF2/HRAS/LEF1	-1.05258987687939
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	8/1479	70/9376	0.724504974403555	HPGDS/GSTP1/GSTO1/SULT1A1/MGST3/MGST2/GSTK1/CBR1	-1.00119786224942
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/1479	31/9376	0.613492115422365	PGLS/TALDO1/TKT	-0.932799292461175
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	7/1479	63/9376	0.704379836225678	PRDM6/ECHS1/TMLHE/ALDH9A1/KMT5A/PIPOX/HADHA	-1.01882169113715
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	8/1479	71/9376	0.71430067898942	LDHB/HIF1A/MAP2K2/PIK3R2/PIK3CD/PGAM1/AKT1/HRAS	-1.04572827303162
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1479	13/9376	0.487647578925469	XRCC6	-0.799966155343766
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/1479	79/9376	0.722212237142784	HPGDS/GSTP1/GSTO1/MGST3/AKR7A2/MGST2/ADH5/GSTK1/CBR1	-1.07298560747626
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1479	23/9376	0.55125378487227	GLUD1/ARG2	-0.932455050635561
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	7/1479	65/9376	0.682706610495657	GNAS/PLCB1/AGTR1/PLCB2/PRKACA/CREB1/ATF6B	-1.11085710034948
Human Diseases	Substance dependence	hsa05034	Alcoholism	24/1479	191/9376	0.796576149867782	GNG2/HDAC9/GNAI2/CALM2/GNG5/GNG10/GNG11/CALM1/CALM3/GNB2/PPP1CA/GNAS/GNB4/GNGT1/GRIN2C/BDNF/PPP1CC/CALML4/HDAC8/PRKACA/HRAS/CREB1/GNAI3/ATF6B	-1.22918606832105
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1479	15/9376	0.422627901735407	HEXA	-0.968453907319315
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1479	15/9376	0.422627901735407	ACP1	-0.968453907319315
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/1479	35/9376	0.543378730802666	AKR1B1/TPI1/PFKFB2	-1.17120287333527
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1479	26/9376	0.487647578925469	SLC46A1/PLB1	-1.13210919436111
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1479	16/9376	0.396213657876944	MIF	-1.04602968164699
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/1479	62/9376	0.613492115422365	RBPJ/PSENEN/APH1A/RFNG/NOTCH3/DLL4	-1.32137091094533
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/1479	94/9376	0.674406226173522	CCL2/S100A9/JUN/CXCL8/HSP90AB1/MMP1/HSP90AA1/IL1B/MAPK10/TNF	-1.37296002470305
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/1479	37/9376	0.514006907516035	MIF/COMT/ADH5	-1.28179752039436
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1479	17/9376	0.372906972119477	SCP2	-1.11990289028572
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/1479	63/9376	0.603754145336295	WNT2/BMP4/BAX/FZD2/GLI2/LEF1	-1.36561683276365
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1479	28/9376	0.452815609002222	B3GNT5/FUT9	-1.2548505928566
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/1479	72/9376	0.616332356697468	CXCL8/TANK/MAP3K1/PIN1/MAPK10/TNF/CASP10	-1.41424687563413
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/1479	38/9376	0.500480409949824	ENPP1/NAMPT/NT5C	-1.33522988667054
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/1479	18/9376	0.352189918112839	CBR4	-1.19050463607965
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/1479	73/9376	0.607889447701612	HPGDS/GSTP1/GSTO1/MGST3/MGST2/ADH5/GSTK1	-1.45544938110748
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/1479	39/9376	0.487647578925469	SHMT2/MAT2A/MAT2B	-1.38750984419988
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1479	30/9376	0.422627901735407	PLAAT3/PLB1	-1.37069928996351
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/1479	20/9376	0.316970926301555	NPL	-1.32326777866872
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/1479	78/9376	0.568922175413048	INPP5D/PLCB1/TPI1/PIK3CD/PLCB2/MTMR6/PIK3CG	-1.65442418125417
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/1479	33/9376	0.384207183395824	BCAT1/IDH3B	-1.53351161643913
NA	NA	hsa04519	Cadherin signaling	50/1479	404/9376	0.784581500746424	WNT2/CDH11/ACTB/PRICKLE1/VIM/ARPC3/ACTG1/YWHAB/GJA1/BRK1/ARPC1B/KRT10/PCDH10/ARPC5/PPP1CA/PCDH12/NCKAP1L/YWHAH/RAC1/PSENEN/KDR/MAP2K2/SCN1B/ACTR2/PCDH18/KRT18/MYO1B/CDC42/ARPC4/VAV1/LRP6/MYO7A/MOB1A/CDH5/MYO1F/TMC8/PPP1CC/APH1A/ENAH/GABRA3/MAPK10/FZD2/RAC2/RAC3/KRT1/DCHS1/HRAS/LEF1/CYFIP1/FAT4	-1.91543625003606
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/1479	54/9376	0.469586557483785	CENPX/RPA3/FANCL/RPA2	-1.69159155708372
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/1479	45/9376	0.422627901735407	ABCC4/ABCC5/ABCG2	-1.6801057221934
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1479	23/9376	0.275626892436135	FUT9	-1.50518341976488
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/1479	24/9376	0.264142438584629	B3GALT6	-1.56201710327209
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	11/1479	117/9376	0.596013707575574	ACTB/ACTG1/CDK2AP1/ZNHIT1/MEAF6/CDK2AP2/RBBP7/TFPT/RUVBL1/POLE3/BRD7	-1.90290091269923
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/1479	36/9376	0.352189918112839	GALNT1/C1GALT1C1	-1.68524936094729
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1479	37/9376	0.342671271677357	ASPA/GLUD1	-1.73369199496543
Organismal Systems	Sensory system	hsa04742	Taste transduction	7/1479	86/9376	0.515999182351369	SCN9A/PLCB1/PDE1C/PLCB2/P2RY1/GABRA3/PRKACA	-1.9513093257136
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/1479	38/9376	0.333653606633216	HEXA/NAGK	-1.78116261508199
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1479	26/9376	0.243823789462735	HHEX	-1.67086951343176
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1479	41/9376	0.309239928099078	GRIN2C/GABRA3	-1.91822987025567
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	6/1479	83/9376	0.458271218749236	SCML1/CSNK2B/PCGF5/UBE2D3/RBBP7/HCFC1	-2.14526843862724
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/1479	66/9376	0.384207183395824	HSD17B2/COMT/HSD17B1/HSD17B12	-2.17255310967572
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/1479	90/9376	0.422627901735407	ATP1B1/ATP1B3/GNAS/ABCC4/PRKACA/ABCG2	-2.3817784628316
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/1479	37/9376	0.171335635838678	NAGK	-2.18558646953649
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	14/1479	168/9376	0.528284877169258	CCND2/CCND1/IL12RB2/PIAS2/SOCS3/PIK3R2/PIK3CD/IL10RA/IRF9/AKT1/IL2RA/CNTFR/PIM1/HRAS	-2.669872003753
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/1479	68/9376	0.279680229089607	ADH5/DHRS4L2/PNPLA4	-2.57982507978046
NA	NA	hsa04382	Cornified envelope formation	16/1479	217/9376	0.467422564131325	S100A9/S100A6/S100A10/S100A11/S100A4/KRT10/SLC27A4/KRT18/S100A13/FURIN/S100A16/CLDN5/S100A12/KRT1/ELOVL1/PPP2CB	-3.43500407020634
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	12/1479	183/9376	0.415699575477449	RAN/NOP10/SNU13/RPP25/EIF6/IMP3/NHP2/CSNK2B/RRP7A/RPP25L/POP7/FBL	-3.45439322200157
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	26/1479	323/9376	0.510293751321389	ZEB2/MARCKS/CCND2/CDK6/VIM/CCND1/STMN1/PRKCB/ZFPM2/HNRNPK/FSCN1/PLAU/MAP2K2/EFNA5/UBE2I/HMOX1/PRKCA/PIK3R2/IRS1/TNXB/PIK3CD/CDKN1B/NOTCH3/CDKN2A/PIM1/HRAS	-3.87596014613968
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	31/1479	370/9376	0.531140471099903	SPX/TSPO/LPAR6/C3AR1/HRH1/TAC3/KISS1/OGFRL1/NR3C1/ADRB1/PTAFR/LYPD6/AGTR1/FPR1/GRIN2C/HRH2/PTGFR/CYSLTR1/APLN/APLNR/CYSLTR2/PTGER4/P2RY1/SSTR1/GABRA3/ADRB2/S1PR1/THRA/S1PR2/P2RY13/FPR2	-3.98213788484612
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	13/1479	449/9376	0.183546638838317	PRKG1/CALM2/CALM1/CALM3/SLC8A1/ARRB2/ARRB1/CALML4/CAMK2D/PDE1C/RGS2/GRK2/PRKACA	-7.67256260136223