category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	116/1362	222/9376	3.5970419758966	RPL27A/RPS23/RPL37A/RPS18/RPL23A/RPL36/RPS11/RPL37/RPL38/RPL32/RPL35/RPS14/RPLP1/RPL39/MRPS16/RPL41/RPLP2/RPL27/RPL23/RPS28/RSL24D1/MRPL21/MRPS6/RPL29/MRPS35/RPL24/MRPS15/MRPL40/RPL14/MRPS24/MRPS28/MRPL47/RPL22L1/RPL7A/MRPS7/RPL26L1/MRPS25/MRPS18C/RPS29/UBA52/RPS24/RPL15/MRPL27/MRPS34/MRPS33/MRPL9/MRPS5/MRPL11/MRPL13/MRPL2/RPL26/RPS15/MRPS12/MRPL22/MRPL1/MRPL38/MRPL4/MRPS14/MRPS18B/MRPL3/MRPL28/MRPL24/MRPS31/MRPL41/MRPS18A/MRPL37/RPS27A/RPL8/RPL18A/RPS25/MRPL43/RPL9/MRPS9/MRPL48/MRPS11/RPL10A/RPS7/MRPL45/RPS4X/MRPL34/MRPS22/MRPL39/MRPS27/RPS21/MRPS23/RPS12/RPS15A/MRPL19/MRPL16/RPS3/MRPL14/MRPL20/MRPL33/RPL22/RPS27L/RPL36A/RPS10/MRPL49/MRPS21/RPL18/MRPL36/MRPL12/MRPL10/RPL30/MRPL51/MRPS17/MRPL35/RPL13A/MRPL32/RPL19/MRPL50/RPL3/RPL5/RPL35A/MRPL44/MRPL17	16.1435679224316
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	103/1362	268/9376	2.64571416047516	MT-ND1/MT-ND3/MT-CYB/MT-CO2/MT-CO3/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND5/PSMD11/ADRM1/MT-ND4L/PSMD4/PSMC4/PSMD2/ATP5F1E/NDUFV3/SDHC/PSMD9/VDAC2/PSMC5/PSMA3/NDUFV1/PSMB2/PSMC2/ATP5PB/PRKACB/SDHB/PSMA5/PSMC6/NDUFS1/PSMD6/PSMA4/SLC39A6/UBE2J2/NDUFA6/NDUFB6/TP53/NDUFS8/COX6C/SLC39A1/ATP5PO/VDAC1/PSMD13/NDUFA5/PSMD3/NDUFS7/UBE2L3/PSMC3/PSMB4/NDUFB11/NDUFB9/SLC39A3/NDUFB5/PSMA2/ATP5PD/NDUFA3/COX4I2/PSMB6/UQCRB/NDUFS4/VDAC3/NDUFS2/PSMD8/PSMA1/CYC1/NDUFA7/ATP5F1A/UBA52/KEAP1/NDUFA11/PSMB1/SDHD/NDUFA12/ATP5MC1/COX5A/COX7A2L/ATP5F1B/TUBB2A/RPS27A/NDUFB1/ATP5F1C/NDUFS3/NDUFA4L2/CALM2/NDUFA2/NDUFV2/COX7C/NDUFB4/TXN2/GNAI1/NDUFB10/PARK7/COX6A1/UQCR10/NDUFAB1/NDUFA8/NDUFB8/UQCR11/UBA7/PSMB5/ATP5F1D	11.2683366921686
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	112/1362	308/9376	2.50327059137632	MT-ND1/MT-ND3/MT-CYB/MT-CO2/MT-CO3/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND5/PSMD11/POLR2E/ADRM1/MT-ND4L/PSMD4/PSMC4/PSMD2/ATP5F1E/NDUFV3/SDHC/PSMD9/VDAC2/PSMC5/PSMA3/NDUFV1/PSMB2/PSMC2/ATP5PB/TFAM/SDHB/PSMA5/PSMC6/DCTN2/NDUFS1/PSMD6/PSMA4/NDUFA6/NDUFB6/TP53/POLR2F/NDUFS8/COX6C/ATP5PO/VDAC1/PSMD13/NDUFA5/PSMD3/NDUFS7/DCTN3/AP2A1/PSMC3/PSMB4/NDUFB11/NDUFB9/NDUFB5/PSMA2/ATP5PD/NDUFA3/COX4I2/POLR2G/PSMB6/UQCRB/NDUFS4/VDAC3/NDUFS2/PSMD8/PSMA1/CYC1/NDUFA7/POLR2H/ATP5F1A/TBPL1/DCTN6/NDUFA11/PSMB1/SDHD/NDUFA12/ATP5MC1/AP2M1/COX5A/COX7A2L/ATP5F1B/TUBB2A/BDNF/TAF4/NDUFB1/ATP5F1C/NDUFS3/ACTR10/NDUFA4L2/GRIA4/NDUFA2/NDUFV2/COX7C/POLR2I/NDUFB4/NDUFB10/COX6A1/UQCR10/POLR2K/NDUFAB1/NDUFA8/NDUFB8/POLR2J/BBC3/DNAH8/UQCR11/CREB3L1/DNAL1/PSMB5/ATP5F1D/CLTC	11.0587562789693
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	103/1362	275/9376	2.57836870911761	MT-ND1/MT-ND3/MT-CYB/MT-CO2/MT-CO3/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND5/C7/RYR2/LAMC1/PSMD11/ADRM1/MT-ND4L/PSMD4/PSMC4/PSMD2/ATP5F1E/NDUFV3/SDHC/PSMD9/VDAC2/PSMC5/PSMA3/NDUFV1/PSMB2/PSMC2/ATP5PB/PRKACB/SDHB/PSMA5/PSMC6/NDUFS1/PSMD6/PSMA4/NDUFA6/NDUFB6/NDUFS8/COX6C/ATP5PO/PIK3CD/VDAC1/PSMD13/NDUFA5/PSMD3/NDUFS7/PSMC3/PSMB4/NDUFB11/NDUFB9/NDUFB5/PSMA2/ATP5PD/NDUFA3/COX4I2/NCF4/ATF6B/PSMB6/UQCRB/NDUFS4/VDAC3/NDUFS2/PSMD8/PIK3R2/PSMA1/CYC1/NDUFA7/ATP5F1A/NDUFA11/PSMB1/SDHD/NDUFA12/ATP5MC1/COX5A/COX7A2L/ATP5F1B/MAPK3/TUBB2A/NDUFB1/ATP5F1C/RAC2/NDUFS3/NDUFA4L2/NDUFA2/NDUFV2/COX7C/NDUFB4/NDUFB10/CAV1/COX6A1/UQCR10/NDUFAB1/BAD/NDUFA8/NDUFB8/CYBB/UQCR11/CREB3L1/PSMB5/ATP5F1D/GRIN2C	10.9516555303312
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	85/1362	205/9376	2.85433902797178	MT-ND1/MT-ND3/MT-CYB/MT-CO2/MT-CO3/MT-ATP6/MT-ND4/MT-ND2/COL3A1/MT-CO1/CD36/COL1A1/MT-ND5/COL1A2/RYR2/MT-ND4L/ATP5F1E/NDUFV3/SDHC/PARP1/VDAC2/PPP1CC/NDUFV1/ATP5PB/SDHB/NDUFS1/AKT1/NDUFA6/NDUFB6/NDUFS8/COX6C/ATP5PO/PIK3CD/VDAC1/NDUFA5/PTPA/NDUFS7/NDUFB11/NDUFB9/NDUFB5/PDHA1/ATP5PD/NDUFA3/COX4I2/NCF4/UQCRB/NDUFS4/VDAC3/NDUFS2/PIK3R2/CYC1/NDUFA7/ATP5F1A/PPARA/NDUFA11/MMP9/SDHD/NDUFA12/ATP5MC1/COX5A/PPP1CA/CPT2/COX7A2L/PDHB/ATP5F1B/NDUFB1/ATP5F1C/RAC2/NDUFS3/NDUFA4L2/NDUFA2/AGTR1/NDUFV2/COX7C/IRS1/NDUFB4/NDUFB10/COX6A1/UQCR10/NDUFAB1/NDUFA8/NDUFB8/CYBB/UQCR11/ATP5F1D	11.0664224681039
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	66/1362	138/9376	3.29234501691885	MT-ND1/MT-ND3/MT-CYB/MT-CO2/MT-CO3/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND5/MT-ND4L/ATP5F1E/NDUFV3/SDHC/NDUFV1/ATP5PB/SDHB/NDUFS1/NDUFA6/NDUFB6/NDUFS8/COX6C/ATP5PO/COX17/NDUFA5/NDUFS7/NDUFB11/NDUFB9/NDUFB5/ATP5PD/NDUFA3/COX4I2/UQCRB/NDUFS4/NDUFS2/CYC1/NDUFA7/ATP5F1A/NDUFA11/SDHD/NDUFA12/ATP5MC1/COX5A/COX7A2L/ATP5F1B/NDUFB1/ATP5F1C/ATP6V1E2/NDUFS3/NDUFA4L2/NDUFA2/NDUFV2/COX7C/NDUFB4/NDUFB10/COX6A1/UQCR10/NDUFAB1/COX11/NDUFA8/NDUFB8/UQCR11/ATP6V0E2/ATP5MG/ATP6V1G1/ATP5F1D	11.183559954422
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	91/1362	235/9376	2.66571687443372	MT-ND1/MT-ND3/MT-CYB/MT-CO2/MT-CO3/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND5/PRKG1/ACTB/MT-ND4L/COX20/ATP5F1E/NDUFV3/SDHC/NDUFV1/ATP5PB/PRKACB/SDHB/ACTG1/NDUFS1/NDUFA6/NDUFB6/NDUFS8/COX6C/ATP5PO/COX17/NDUFA5/NDUFAF3/NDUFS7/SMARCD2/NDUFB11/NDUFB9/COA3/NDUFB5/ATP5PD/NDUFA3/COX4I2/UQCRB/NDUFS4/NDUFS2/CYC1/NDUFA7/COA4/ATP5F1A/NDUFAF6/COX14/RPS6KB2/NDUFAF2/NDUFAF7/NDUFA11/SDHD/SMARCB1/NDUFA12/ATP5MC1/SMARCD1/COX5A/CPT2/COA1/COX7A2L/ATP5F1B/COA5/NDUFB1/ATP5F1C/NDUFS3/NDUFA4L2/NDUFA2/NDUFV2/COX7C/NDUFB4/NDUFAF4/COX16/NDUFB10/COA6/COX6A1/UQCR10/MLST8/NDUFAB1/COX11/NDUFA8/NDUFB8/ACTL6A/UQCR11/NDUFAF8/ATP5MG/CREB3L1/NDUFAF1/HRAS/ATP5F1D	10.6607506361389
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	114/1362	368/9376	2.13254165868608	MT-ND1/MT-ND3/MT-CYB/MT-CO2/MT-CO3/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND5/ACTB/PSMD11/ADRM1/MT-ND4L/PSMD4/PSMC4/PSMD2/ATP5F1E/NDUFV3/SDHC/PSMD9/PSMC5/PSMA3/NDUFV1/PSMB2/PSMC2/ATP5PB/NUP214/SDHB/PSMA5/ACTG1/PSMC6/DCTN2/NDUFS1/PSMD6/PSMA4/NDUFA6/NDUFB6/TP53/NDUFS8/COX6C/ATP5PO/VDAC1/PSMD13/NDUFA5/PSMD3/NDUFS7/DCTN3/PSMC3/PSMB4/NDUFB11/NDUFB9/NDUFB5/PSMA2/RAE1/ATP5PD/NDUFA3/COX4I2/FIG4/CCS/SEH1L/PSMB6/WDR41/UQCRB/NDUFS4/NDUFS2/PSMD8/PSMA1/CYC1/NDUFA7/ATP5F1A/GLE1/DCTN6/NDUFA11/PSMB1/SDHD/NDUFA12/ATP5MC1/COX5A/ALYREF/COX7A2L/ATP5F1B/TUBB2A/ALS2/NDUFB1/ATP5F1C/NUP205/NDUFS3/ACTR10/NDUFA4L2/NDUFA2/NDUFV2/COX7C/CHCHD10/NDUFB4/NDUFB10/TNFRSF1A/COX6A1/SIGMAR1/NUP155/UQCR10/NUP107/NDUFAB1/BAD/NDUFA8/NDUFB8/DNAH8/UQCR11/TOMM40/DNAL1/NUP160/PSMB5/ATP5F1D/GRIN2C	9.13720627434762
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	81/1362	227/9376	2.45640319043645	MT-ND1/MT-ND3/MT-CYB/MT-CO2/MT-CO3/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND5/MT-ND4L/ATP5F1E/NDUFV3/SDHC/HGF/VDAC2/NDUFV1/ATP5PB/SDHB/NDUFS1/CBR1/AKT1/NDUFA6/NDUFB6/NDUFS8/COX6C/ATP5PO/PIK3CD/VDAC1/NDUFA5/NDUFS7/NDUFB11/NDUFB9/ACP1/NDUFB5/MAP2K2/ATP5PD/NDUFA3/COX4I2/UQCRB/NDUFS4/VDAC3/NDUFS2/PIK3R2/CYC1/NDUFA7/ATP5F1A/KEAP1/NDUFA11/IKBKG/SDHD/NDUFA12/ATP5MC1/COX5A/COX7A2L/ATP5F1B/MAPK3/NDUFB1/ATP5F1C/AKR1A1/NDUFS3/NDUFA4L2/NDUFA2/NDUFV2/ARNT/COX7C/MGST2/PRKD1/NDUFB4/NDUFB10/COX6A1/UQCR10/NDUFAB1/BAD/NDUFA8/NDUFB8/UQCR11/PLD1/HRAS/ATP5F1D/GSTM4	9.15708529235872
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	116/1362	388/9376	2.05810133672434	MT-ND1/MT-ND3/MT-CYB/MT-CO2/MT-CO3/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND5/WNT2/PSMD11/ADRM1/MT-ND4L/PSMD4/PSMC4/PSMD2/ATP5F1E/NDUFV3/SDHC/PSMD9/VDAC2/PSMC5/PSMA3/NDUFV1/PSMB2/PSMC2/ATP5PB/APH1A/SDHB/PSMA5/PSMC6/NDUFS1/NCSTN/PSMD6/AKT1/PSMA4/SLC39A6/NDUFA6/NDUFB6/NDUFS8/COX6C/SLC39A1/ATP5PO/PIK3CD/VDAC1/PSMD13/NDUFA5/PSMD3/CASP7/NDUFS7/PSMC3/PSMB4/NDUFB11/NDUFB9/SLC39A3/NDUFB5/MAP2K2/PSMA2/ATP5PD/NDUFA3/COX4I2/PSENEN/PSMB6/UQCRB/HSD17B10/NDUFS4/VDAC3/NDUFS2/PSMD8/PIK3R2/PSMA1/CYC1/NDUFA7/ATP5F1A/NDUFA11/IKBKG/PSMB1/SDHD/NDUFA12/ATP5MC1/COX5A/APOE/COX7A2L/ATP5F1B/MAPK3/TUBB2A/CAPN1/NDUFB1/ATP5F1C/NDUFS3/NDUFA4L2/CALM2/NDUFA2/NDUFV2/COX7C/IRS1/NDUFB4/NDUFB10/TNFRSF1A/COX6A1/NAE1/UQCR10/NDUFAB1/BAD/NDUFA8/NDUFB8/LRP6/DVL1/CYBB/UQCR11/HRAS/PSMB5/ATP5F1D/BACE1/GRIN2C	8.77528271079487
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	124/1362	480/9376	1.77836514929026	MT-ND1/MT-ND3/MT-CYB/MT-CO2/MT-CO3/MT-ATP6/MT-ND4/MT-ND2/MT-CO1/MT-ND5/WNT2/RYR2/PSMD11/ADRM1/MT-ND4L/PSMD4/PSMC4/PSMD2/ATP5F1E/NDUFV3/SDHC/PSMD9/VDAC2/PSMC5/PSMA3/NDUFV1/PSMB2/PSMC2/ATP5PB/SDHB/PSMA5/PSMC6/DCTN2/NDUFS1/PSMD6/PSMA4/UBE2J2/NDUFA6/NDUFB6/NDUFS8/COX6C/ATP5PO/VDAC1/PSMD13/NDUFA5/PSMD3/CASP7/NDUFS7/DCTN3/UBE2L3/PSMC3/PSMB4/NDUFB11/NDUFB9/NDUFB5/MAP2K2/PSMA2/ATP5PD/NDUFA3/COX4I2/FIG4/CCS/PSMB6/WDR41/UQCRB/HSD17B10/NDUFS4/VDAC3/NDUFS2/PSMD8/PSMA1/CYC1/NDUFA7/ATP5F1A/UBA52/DCTN6/NDUFA11/PSMB1/SDHD/NDUFA12/ATP5MC1/COX5A/COX7A2L/ATP5F1B/MAPK3/TUBB2A/ALS2/RPS27A/BDNF/CAPN1/NDUFB1/ATP5F1C/NDUFS3/ACTR10/NDUFA4L2/GRIA4/CALM2/NDUFA2/NDUFV2/COX7C/NDUFB4/BAK1/NDUFB10/TNFRSF1A/PARK7/COX6A1/SIGMAR1/UQCR10/NDUFAB1/BAD/NDUFA8/NDUFB8/DNAH8/LRP6/DVL1/CYBB/UQCR11/UBA7/TOMM40/DNAL1/HRAS/PSMB5/ATP5F1D/GRIN2C	7.21699055613877
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	72/1362	238/9376	2.08255284492652	F13A1/RPL27A/RPS23/C7/RPL37A/RPS18/RPL23A/RPL36/RPS11/RPL37/RPL38/RPL32/RPL35/RPS14/RPLP1/RPL39/RPL41/RPLP2/RPL27/RPL23/RPS28/RSL24D1/IL6ST/RPL29/RPL24/PIK3CD/RPL14/RPL22L1/RPL7A/C1S/RPL26L1/IRAK4/IRF3/MAVS/PIK3R2/RPS29/UBA52/RPS24/RPL15/RPL26/IKBKG/RPS15/MAPK3/CCL2/RPS27A/RPL8/RPL18A/RPS25/RPL9/RPL10A/AGTR1/C2/RPS7/RPS4X/RPS21/RPS12/RPS15A/RPS3/TNFRSF1A/RPL22/RPS27L/RPL36A/RPS10/RPL18/RPL30/MMP1/RPL13A/CYBB/RPL19/RPL3/RPL5/RPL35A	6.97367221494437
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	25/1362	46/9376	3.74130115558961	PSMD11/ADRM1/PSMD4/PSMC4/PSMD2/PSMD9/PSMC5/PSMA3/PSMB2/PSMC2/PSMA5/PSMC6/PSMD6/PSMA4/PSMD13/PSMD3/PSMC3/PSMB4/PSMB8/PSMA2/PSMB6/PSMD8/PSMA1/PSMB1/PSMB5	7.68323941061972
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	52/1362	157/9376	2.2800490099797	MT-CYB/MT-CO2/MT-CO3/MT-CO1/NDUFV3/SDHC/NDUFV1/SDHB/NDUFS1/AKT1/NDUFA6/NDUFB6/NDUFS8/COX6C/PIK3CD/NDUFA5/CASP7/NDUFS7/NDUFB11/NDUFB9/NDUFB5/NDUFA3/COX4I2/UQCRB/NDUFS4/NDUFS2/PIK3R2/CYC1/NDUFA7/PPARA/CEBPA/NDUFA11/SDHD/NDUFA12/COX5A/COX7A2L/NDUFB1/NDUFS3/NDUFA4L2/NDUFA2/NDUFV2/COX7C/IRS1/NDUFB4/NDUFB10/TNFRSF1A/COX6A1/UQCR10/NDUFAB1/NDUFA8/NDUFB8/UQCR11	6.66782264561082
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	43/1362	149/9376	1.98665602302181	MT-ND1/MT-ND3/MT-ND4/MT-ND2/MT-ND5/GNGT1/MT-ND4L/NDUFV3/NDUFV1/PRKACB/NDUFS1/GNG11/NDUFA6/NDUFB6/NDUFS8/NDUFA5/NDUFS7/NDUFB11/NDUFB9/NDUFB5/NDUFA3/NDUFS4/NDUFS2/NDUFA7/NDUFA11/NDUFA12/MAPK3/NDUFB1/NDUFS3/NDUFA4L2/GRIA4/NDUFA2/NDUFV2/NDUFB4/GNAI1/GNB2/KCNJ5/NDUFB10/GABRA3/NDUFAB1/NDUFA8/NDUFB8/GABRR2	5.00470136918828
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	21/1362	56/9376	2.58149779735683	MAN1B1/DDOST/MGAT2/STT3A/DPAGT1/ALG5/ALG3/B4GALT3/DPM3/KRTCAP2/ALG8/MOGS/DPM2/ST6GAL1/ALG12/FUT8/OSTC/MAN1C1/MGAT4B/ALG1/TUSC3	4.89332624383976
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	18/1362	48/9376	2.58149779735683	ALDH9A1/HMGCLL1/DLD/IVD/ECHS1/ACADM/HSD17B10/HADH/HIBCH/PCCB/DBT/ACADS/AUH/HIBADH/MCCC2/BCAT2/ALDH7A1/ACAD8	4.52839669028357
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	13/1362	31/9376	2.88683624650656	SRP19/SEC11C/SEC61A1/TMEM208/SGTA/SRP9/GET3/SRPRB/SPCS1/SRP14/GET1/SPCS2/IMMP1L	4.33785396752341
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	36/1362	142/9376	1.74523794750884	UBE2F/UBE2E3/CDC26/CUL5/UBE2I/ANAPC10/UBE2J2/UBA2/UBE3C/RCHY1/RNF7/UBE2L3/ANAPC16/UBE2M/ANAPC15/CDC16/RHOBTB2/UBA52/ANAPC4/KEAP1/CDC34/UBE3B/UBE2D4/PRPF19/RPS27A/ANAPC11/FBXO4/KLHL9/CDC23/ANAPC1/RHOBTB1/PIAS3/UBA7/UBOX5/WWP1/PIAS4	3.68887314802302
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	12/1362	30/9376	2.75359765051395	IDH2/SDHC/MDH2/SDHB/IDH3B/DLD/IDH1/PDHA1/SUCLG1/MDH1/SDHD/PDHB	3.96576720359499
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	36/1362	144/9376	1.72099853157122	PSMD11/RBPJ/ADRM1/PSMD4/PSMC4/PSMD2/PSMD9/VDAC2/PSMC5/PSMA3/PSMB2/PSMC2/CIC/PSMA5/PSMC6/PSMD6/AKT1/PSMA4/PIK3CD/VDAC1/PSMD13/PSMD3/PSMC3/PSMB4/PSMA2/PSMB6/VDAC3/PSMD8/PIK3R2/PSMA1/TBPL1/PSMB1/OMA1/ATXN10/PSMB5/GRIN2C	3.5943242360988
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	16/1362	47/9376	2.34348736213953	ALDH9A1/MDH2/DLD/GLO1/HAGH/PDHA1/GRHPR/MDH1/ME2/ADH5/PDHB/AKR1A1/ACYP2/ACYP1/LDHB/ALDH7A1	3.80640057988092
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	24/1362	85/9376	1.94371598859808	ENPP1/HPRT1/NME3/ITPA/NUDT16/TK2/GMPR2/DCTD/NT5C3B/NTPCR/APRT/IMPDH1/DCK/CANT1/NT5C/DUT/NME1/NME6/DCTPP1/DTYMK/AK6/NME4/AK9/HDDC2	3.60303987712453
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	15/1362	44/9376	2.3468161794153	MAN1B1/DDOST/MGAT2/STT3A/ALG3/B4GALT3/KRTCAP2/ALG12/FUT8/OSTC/MAN1C1/ST3GAL3/MGAT4B/ALG1/TUSC3	3.6914485611807
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	22/1362	78/9376	1.94163936895214	C1D/PFKL/EXOSC6/CNOT8/LSM2/NUDT16/LSM8/EXOSC1/LSM3/LSM1/LSM7/EXOSC7/EXOSC8/PABPC4L/LSM5/ZCCHC7/EDC4/LSM4/EXOSC4/LSM6/EXOSC3/EDC3	3.44260076538294
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	29/1362	116/9376	1.72099853157122	IDH2/SDHC/MDH2/PFKL/SDHB/IDH3B/DLD/IDH1/PDHA1/ECHS1/SUCLG1/ALDOA/PGLS/PRPS1/MDH1/ESD/ME2/SHMT1/SDHD/ADH5/PDHB/HIBCH/PCCB/RPIA/SHMT2/FBP1/ACADS/ENO4/PSPH	3.2211237087619
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	11/1362	30/9376	2.52413117963779	PIGP/PIGF/PIGC/PIGH/GPAA1/PIGX/PIGB/DPM2/PIGU/PGAP3/PIGL	3.44682797927597
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	17/1362	59/9376	1.98352373130242	ENPP1/NME3/TK2/DCTD/NUDT2/NT5C3B/DCK/CANT1/NT5C/DUT/NME1/NME6/DCTPP1/DTYMK/NME4/AK9/HDDC2	3.12408127947809
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	21/1362	83/9376	1.74173345363834	HMGCLL1/IDH2/ECH1/PMVK/MPV17/IDH1/PEX16/SCP2/PEX11G/PEX14/PEX2/GNPAT/PEX10/CROT/PRDX5/MLYCD/PEX3/PEX11B/PEX7/CRAT/ACOT8	2.79806930675212
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	7/1362	17/9376	2.83458581670554	PAPSS1/INMT/KYAT3/SCLY/SEPSECS/SEPHS1/TXNRD2	3.12102531734054
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	11/1362	36/9376	2.10344264969816	RFC1/RFC2/RNASEH2C/POLE4/POLA1/SSBP1/PCNA/PRIM2/MCM4/PRIM1/RPA3	2.73449479646233
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	25/1362	108/9376	1.59351715886224	MAGOH/NUP214/THOC7/UBE2I/NCBP2/CSE1L/SUMO1/RAE1/XPO7/SEH1L/UPF3A/IPO9/GLE1/RAN/ALYREF/UPF2/IPO11/NUP205/SNUPN/THOC6/AAAS/NUP155/NUP107/MAGOHB/NUP160	2.55741770372999
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	10/1362	32/9376	2.15124816446402	DLD/ECHS1/SUCLG1/HIBCH/PCCB/DBT/ACSS3/MLYCD/ACADS/LDHB	2.68922443049797
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	33/1362	154/9376	1.47514159848962	PANK3/NME3/VKORC1/UROS/DLD/PNPO/GGCX/GSS/SHMT1/ALAS2/UROD/MOCS2/COQ4/LIAS/MMAB/AKR1A1/NME1/NME6/FECH/SHMT2/MTHFD1/UGDH/COQ5/COASY/AK6/QPRT/PMM1/NME4/MPI/AK9/BCAT2/DHFR/COQ6	2.45087058121934
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	17/1362	68/9376	1.72099853157122	RUNX1T1/AKT1/PIK3CD/MAP2K2/PIK3R2/PIM1/RPS6KB2/CEBPA/IKBKG/MAPK3/CD14/EIF4EBP1/CSF1R/LEF1/BAD/DUSP6/HRAS	2.45985876377863
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	10/1362	34/9376	2.02470415478967	POLR2E/POLR1D/POLR2F/POLR2G/POLR2H/POLR2I/POLR1A/POLR2K/POLR2J/POLR3K	2.46755900870517
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	12/1362	44/9376	1.87745294353224	PARP1/APEX1/RFC1/RFC2/POLE4/XRCC1/SMUG1/PCNA/PARP2/MPG/POLL/NEIL2	2.40498477476863
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	5/1362	12/9376	2.86833088595203	VKORC1/GGCX/COQ4/COQ5/COQ6	2.66970476580161
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	27/1362	128/9376	1.45209251101322	ENPP1/PDE3A/HPRT1/NME3/PAPSS1/PGM2/ITPA/NUDT16/GMPR2/GUCY1A2/PRPS1/NUDT2/NTPCR/APRT/NUDT5/ATIC/IMPDH1/DCK/CANT1/NT5C/NME1/NME6/AK6/NME4/ADPRM/AK9/HDDC2	2.12303869680397
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	16/1362	67/9376	1.64393889582922	ALDH9A1/PFKL/ALDH3B1/DLD/PGM2/PDHA1/ALDOA/G6PC3/ADH5/PDHB/AKR1A1/FBP1/BPGM/LDHB/ENO4/ALDH7A1	2.18062038519656
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	9/1362	31/9376	1.99857893988916	PFKL/PGM2/ALDOA/DERA/PGLS/PRPS1/RPIA/FBP1/SHPK	2.2957422109648
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	15/1362	63/9376	1.63904622054402	POLR2E/POLR2F/RFC1/RFC2/POLE4/POLR2G/XPA/POLR2H/CETN2/POLR2I/PCNA/POLR2K/GTF2H5/POLR2J/RPA3	2.09800861343239
NA	NA	hsa04518	Integrin signaling	31/1362	154/9376	1.38573907736903	SPP1/LAMA2/COL1A1/COL1A2/ACTB/COL6A1/COL6A2/LAMC1/FREM1/PDGFRA/HGF/ICAM2/ACTG1/CCND2/FERMT3/AKT1/PIK3CD/LAMC3/VCAM1/COL4A1/PIK3R2/VCL/VTN/RAC2/LAMA4/ITGA7/ITGA6/ITGAE/FRAS1/COL4A2/ITGA9	1.98971540222049
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	7/1362	23/9376	2.09512864713018	FNTA/PMVK/FDPS/PCYOX1/PDSS2/GGPS1/ICMT	2.16771964516445
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	7/1362	23/9376	2.09512864713018	RFC1/RFC2/SSBP1/PCNA/MLH3/MSH2/RPA3	2.16771964516445
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	10/1362	38/9376	1.81157740165391	PGM2/GALK1/UXS1/AMDHD2/UAP1L1/UGDH/GNPDA2/PMM1/MPI/GALK2	2.06654245604655
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	13/1362	54/9376	1.65725784521673	MDH2/DNMT3A/GSS/APIP/ADI1/ENOPH1/MDH1/KYAT3/MTAP/MPST/LDHB/BCAT2/SRM	1.99676811092444
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	12/1362	49/9376	1.68587611255956	COLGALT1/FUT11/MFNG/GXYLT2/B4GALT3/FUT10/POFUT2/ST6GAL1/C1GALT1C1/ST3GAL3/POMT1/B3GLCT	1.98436817032313
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/1362	10/9376	2.75359765051395	ETHE1/PAPSS1/SELENBP1/MPST	2.2871908300359
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	46/1362	250/9376	1.26665491923642	DAB2/CHMP4A/ARF5/PDGFRA/VPS4A/RAB4A/EPN1/ARPC5L/ARAP2/ARPC1A/ARFGAP2/CHMP2A/CHMP5/AP2A1/WASHC3/STAMBP/VPS26B/RAB11FIP2/RBSN/GIT2/VPS28/RUFY2/SNX12/VPS29/PARD3/SNX4/AP2M1/GIT1/CHMP6/CHMP7/VPS45/SH3GLB2/ARFGAP1/CAV1/MVB12A/ARPC4/LDLRAP1/DNM3/SNX2/PLD1/FOLR2/HRAS/VPS25/WWP1/CLTC/FGFR3	1.76168758991784
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	64/1362	362/9376	1.21705973503379	SPP1/LAMA2/COL1A1/COL1A2/GNGT1/COL6A1/COL6A2/MAGI1/LAMC1/PDGFRA/PPP2CB/HGF/EIF4E2/CCND2/IGF2/RBL2/GNG11/AKT1/ANGPT1/TP53/PIK3CD/STK11/PRLR/FGF7/LAMC3/CSH1/MAP2K2/PKN2/JAK3/COL4A1/ATF6B/PIK3R2/G6PC3/EFNA5/RPS6KB2/VTN/IKBKG/CDK4/MAPK3/THEM4/CRTC2/FGF10/BDNF/PPP2R5D/EIF4EBP1/LAMA4/IRS1/ANGPT2/GNB2/CSF1R/ITGA7/ITGA6/MLST8/BAD/YWHAE/GDNF/CREB3L1/COL4A2/HRAS/ITGA9/LPAR5/KITLG/FGFR3/PPP2R3B	1.73629813942652
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	17/1362	78/9376	1.50035769419029	ACTB/ACTG1/ARPC5L/ARPC1A/PIK3CD/SHC1/PIK3R2/SEPTIN11/CRKL/VCL/MAD2L2/SEPTIN1/CAV1/ARPC4/DNM3/DOCK1/CLTC	1.82929031833236
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	27/1362	137/9376	1.35669957233352	ACTB/PARP1/ACTG1/CSF2RB/AKT1/TP53/PIK3CD/CASP7/MAP2K2/PIK3R2/ATM/DFFA/IKBKG/MAPK3/CTSF/CAPN1/CTSC/LMNB2/BAK1/TNFRSF1A/CASP2/PARP2/BAD/BBC3/CASP6/ENDOG/HRAS	1.73380364485265
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	21/1362	103/9376	1.40353278302896	PPP2CB/PPP1CC/MAGOH/NCBP2/CPSF2/UPF3A/PABPN1/GLE1/FIP1L1/PPP1CA/ALYREF/UPF2/PPP2R5D/PABPC4L/PELO/CPSF1/MAGOHB/CPSF4/CSTF2T/CSTF1/PPP2R3B	1.69760571261139
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	10/1362	41/9376	1.67902295763046	DLD/GRHPR/GATM/SHMT1/ALAS2/SHMT2/SRR/BPGM/ALDH7A1/PSPH	1.79625813537362
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	16/1362	75/9376	1.46858541360744	IGFBP3/SIVA1/CCND2/MDM4/TP53/RCHY1/SESN3/CCNG1/ATM/ZMAT3/CDK4/TP53I3/EI24/CCNG2/CHEK2/BBC3	1.6795931623687
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	18/1362	87/9376	1.42427464681756	MT-CYB/MT-CO2/MT-CO3/MT-CO1/RYR2/COX6C/COX4I2/CACNA2D4/UQCRB/CYC1/COX5A/COX7A2L/SLC9A6/TNNT2/COX7C/COX6A1/UQCR10/UQCR11	1.63897280843725
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	37/1362	203/9376	1.25471814124404	SPP1/LAMA2/COL1A1/COL1A2/ACTB/COL6A1/COL6A2/LAMC1/PDGFRA/HGF/PPP1CC/ACTG1/CCND2/AKT1/PIK3CD/LAMC3/SHC1/COL4A1/PIK3R2/CRKL/VCL/VTN/PPP1CA/MAPK3/RAC2/LAMA4/CAV1/ITGA7/ITGA6/ROCK2/DOCK1/BAD/PAK4/COL4A2/HRAS/ARHGAP5/ITGA9	1.51252207572588
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	15/1362	71/9376	1.45436495625737	PDGFRA/IDH2/PFKL/AKT1/TP53/PIK3CD/IDH1/PDHA1/MAP2K2/PIK3R2/PDHB/MAPK3/LDHB/HRAS/FGFR3	1.58425591318508
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	10/1362	43/9376	1.60092886657788	ALDH9A1/ECI1/ECHS1/ACADM/HADH/ADH5/CPT2/GCDH/ACADS/ALDH7A1	1.62815663866573
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	18/1362	89/9376	1.39226847497896	SPP1/LAMA2/CD36/COL1A1/COL1A2/COL6A1/COL6A2/LAMC1/FREM1/LAMC3/COL4A1/VTN/LAMA4/ITGA7/ITGA6/FRAS1/COL4A2/ITGA9	1.53281665465459
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	24/1362	125/9376	1.3217268722467	PPP2CB/CERS2/AKT1/DEGS1/TP53/PIK3CD/S1PR1/MAP2K2/ORMDL1/PIK3R2/MAPK3/RAC2/PPP2R5D/SGPP1/SGMS1/GNAI1/SPHK2/TNFRSF1A/ROCK2/SMPD1/PLD1/S1PR2/HRAS/PPP2R3B	1.49278590521601
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	40/1362	224/9376	1.22928466540801	MMP7/VDAC2/CDC26/PRKACB/CCND2/ANAPC10/AKT1/FDPS/TP53/PIK3CD/VDAC1/ANAPC16/MAP2K2/JAK3/ATF6B/VDAC3/PIK3R2/ATM/ANAPC15/CDC16/ANAPC4/TBPL1/IKBKG/CDK4/RAN/TCF3/NFATC2/MAPK3/CRTC2/ANAPC11/TNFRSF1A/PTTG1/KAT2A/CHEK2/CDC23/NFYB/ANAPC1/CREB3L1/DLG1/HRAS	1.43182696288843
Genetic Information Processing	Transcription	hsa03040	Spliceosome	43/1362	243/9376	1.21815533921913	RBM17/BUD31/PRPF38A/SNRPD2/TXNL4A/MAGOH/SRSF1/SNRPB2/THOC7/LSM2/SF3B3/NCBP2/SNRNP27/CWC15/SF3B5/SNRPA1/RBMX2/SNRPC/SNU13/LSM8/PPIE/PHF5A/LSM3/LSM7/PRPF31/ALYREF/SNRPD1/PPIH/SNRPD3/PRPF19/SNRNP40/LSM5/SRSF9/SRSF8/THOC6/SF3B6/PLRG1/LSM4/SNRPG/MAGOHB/LSM6/GPKOW/PPIL1	1.42040364289305
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	8/1362	33/9376	1.66884706091755	IDH2/IDH3B/DLD/IDH1/PDHA1/PDHB/DBT/BCAT2	1.58668290065794
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	10/1362	44/9376	1.5645441196102	TAF10/TAF1/TAF9/TBPL1/TAF12/TAF4/GTF2A2/TAF9B/GTF2H5/TAF6	1.54734225049392
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/1362	28/9376	1.72099853157122	ELOVL2/HSD17B12/ELOVL1/ECHS1/HADH/THEM4/HACD3	1.57508344539801
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	29/1362	158/9376	1.26351790925482	CDKN1C/PPP2CB/CDC26/CCND2/SMC3/RBL2/ANAPC10/TP53/ANAPC16/ATM/ANAPC15/CDC16/ORC3/ORC2/ANAPC4/CDK4/E2F4/MAD2L2/ANAPC11/PPP2R5D/PCNA/ORC4/PTTG1/CHEK2/CDC23/ANAPC1/MCM4/YWHAE/RBL1	1.37711386443635
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	20/1362	104/9376	1.32384502428555	PLPP3/PLAAT3/DGKZ/LYPLA1/PLPP5/CDIPT/PLA2G15/LYPLA2/AGPAT2/PLA2G2A/GNPAT/SGMS1/PLA2G12A/ADPRM/CRLS1/PLD1/PEMT/CEPT1/DGKH/PTDSS2	1.36904180470003
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	12/1362	57/9376	1.44926192132313	ELOVL2/HSD17B12/ELOVL1/ECHS1/SCP2/ACADM/HADH/CPT2/HACD3/ACADS/HSD17B8/CBR4	1.40249688388846
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	13/1362	63/9376	1.42050672447148	PRDM6/KMT5A/ALDH9A1/NSD1/COLGALT1/DLD/SMYD2/ECHS1/HADH/EHMT2/TMLHE/GCDH/ALDH7A1	1.38053665225713
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	22/1362	117/9376	1.2944262459681	ACTB/RBBP7/MBD3/ING3/ACTG1/BCL7C/TFPT/SMARCD2/RUVBL1/MEAF6/ZNHIT1/CDK2AP1/SMARCB1/SMARCD1/ACTR6/DPF2/YEATS4/INO80C/DMAP1/ACTL6A/INO80B/VPS72	1.32110377445998
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1362	19/9376	1.81157740165391	DLD/PDHA1/PDHB/LIAS/DBT	1.45978183213697
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	28/1362	157/9376	1.22771869768138	IGFBP3/VDAC2/PPP1CC/CCND2/RBL2/AKT1/TP53/PIK3CD/VDAC1/MRE11/MAP2K2/VDAC3/PIK3R2/ATM/GATA4/CDK4/PPP1CA/E2F4/NFATC2/MAPK3/CAPN1/EIF4EBP1/CALM2/RAD1/CHEK2/RRAS/HRAS/RBL1	1.1861951201798
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	9/1362	42/9376	1.47514159848962	ALDH9A1/DLD/ECHS1/INMT/HADH/KYAT3/AOC1/GCDH/ALDH7A1	1.27222323886949
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	7/1362	31/9376	1.55445028658046	ALDH9A1/ALDH3B1/ECHS1/HIBCH/MLYCD/ACADS/ALDH7A1	1.2746863326855
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/1362	31/9376	1.55445028658046	MDH2/DLD/GRHPR/MDH1/SHMT1/PCCB/SHMT2	1.2746863326855
NA	NA	hsa04981	Folate transport and metabolism	7/1362	31/9376	1.55445028658046	MTHFS/SHMT1/SHMT2/MTHFD1/SLCO2B1/FOLR2/DHFR	1.2746863326855
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	42/1362	248/9376	1.16583771493534	ACTB/SNX18/ACTG1/DYNLT1/DCTN2/ARPC5L/AKT1/ARPC1A/PIK3CD/VPS39/CSE1L/DYNC1I2/CASP7/DCTN3/FBXO22/MAP2K2/IRAK4/RILP/DCTN6/IKBKG/NLRC4/BRK1/DYNLRB1/MAPK3/TUBB2A/VPS33A/VPS16/CD14/ACTR10/PYCARD/TXN2/RPS3/GSDMD/BAK1/TNFRSF1A/SNX33/ARPC4/LEF1/RIPK3/ROCK2/RRAS/HRAS	1.09111582011392
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/1362	37/9376	1.48843116243997	PGM2/GALK1/UXS1/UAP1L1/UGDH/PMM1/MPI/GALK2	1.22716670000059
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1362	37/9376	1.48843116243997	TP53/MAP2K2/NCOA4/MAPK3/BAK1/RXRB/LEF1/HRAS	1.22716670000059
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1362	15/9376	1.8357317670093	ST3GAL5/GLB1/SLC33A1/ST6GALNAC6	1.33536792455553
Human Diseases	Cancer: specific types	hsa05218	Melanoma	14/1362	73/9376	1.32021805161628	PDGFRA/HGF/AKT1/TP53/PIK3CD/FGF7/MAP2K2/PIK3R2/CDK4/MAPK3/FGF10/BAK1/BAD/HRAS	1.13225762286363
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	14/1362	73/9376	1.32021805161628	RARB/HGF/AKT1/TP53/PIK3CD/MAP2K2/JAK3/PIK3R2/CDK4/MAPK3/BAK1/RXRB/BAD/HRAS	1.13225762286363
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	7/1362	32/9376	1.50587371512482	PFKL/GLB1/PGM2/AKR1B1/GALK1/G6PC3/GANC	1.18168088814611
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/1362	21/9376	1.63904622054402	ENPP1/PANK3/AASDHPPT/COASY/BCAT2	1.20856369799325
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	17/1362	93/9376	1.25836451770799	LAMA2/RARB/LAMC1/AKT1/TP53/PIK3CD/LAMC3/COL4A1/PIK3R2/IKBKG/CDK4/LAMA4/BAK1/RXRB/ITGA6/COL4A2/CKS1B	1.03223764135218
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	29/1362	169/9376	1.18127709859326	PPP2CB/PRKACB/AKT1/PIK3CD/STK11/VPS39/YKT6/SUPT20H/MAP2K2/WDR41/PIK3R2/ATG4C/NBR1/UBA52/RPS6KB2/RRAGA/MAPK3/VPS33A/RPS27A/VPS16/IRS1/GABARAPL2/ATG9A/MLST8/BAD/RRAS/DEPTOR/HRAS/ATG4D	0.980340049764258
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	14/1362	75/9376	1.28501223690651	IDH2/PFKL/IDH3B/IDH1/ALDOA/PRPS1/SHMT1/PYCR2/RPIA/SHMT2/ARG2/ENO4/BCAT2/PSPH	1.02159518926174
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/1362	39/9376	1.41210135923792	DLD/MTHFS/SHMT1/ATIC/SHMT2/MTHFD1/ALDH7A1/DHFR	1.06311976891552
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	10/1362	51/9376	1.34980276985978	ENPP2/PLPP3/PLAAT3/PLA2G2A/TMEM86A/PAFAH1B3/PLA2G12A/GDPD1/PLD1/CEPT1	1.03260312444543
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	31/1362	184/9376	1.15980335823278	SLIT2/EPHA3/ROBO2/RYK/PIK3CD/SEMA6D/ROBO1/PLXNA1/PLXNB2/FES/PIK3R2/UNC5C/EFNA5/PARD3/ENAH/PLXNA2/NFATC2/MAPK3/RASA1/RAC2/EPHA7/SLIT3/GNAI1/ROCK2/RRAS/NTNG2/PAK4/HRAS/NTNG1/SEMA3D/EPHA6	0.902483620084467
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/1362	28/9376	1.47514159848962	CBR1/QDPR/AKR1B1/PCBD1/MOCS2/DHFR	1.03798778115405
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	15/1362	83/9376	1.24409532402739	POLR2E/POLR1D/POLR2F/CASP7/IRF3/MAVS/POLR2H/IKBKG/DDX41/PYCARD/GSDMD/RIPK3/POLR2K/POLR3K/ZDHHC11	0.920810070966225
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	41/1362	250/9376	1.12897503671072	BORCS7/MCOLN1/NAGA/FUCA1/GLB1/VPS39/CTNS/AP2A1/ACP2/NAGLU/VPS26B/CLN6/FIG4/LGMN/CD63/KXD1/PLA2G15/LAMTOR1/VPS29/RRAGA/AP2M1/AP4E1/VPS33A/CTSF/VPS16/ATP6V1E2/TTI1/MFSD8/CTSC/CD164/ROGDI/MLST8/SMPD1/DEPTOR/BLOC1S1/ATP6V0E2/ATP6V1G1/AP1G2/SLC38A9/CLTC/AP4M1	0.852088992894309
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	14/1362	77/9376	1.25163529568816	AKT1/TP53/PIK3CD/SHC1/MAP2K2/PIK3R2/CRKL/IKBKG/CDK4/CTBP1/MAPK3/BAK1/BAD/HRAS	0.914004468854842
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	21/1362	122/9376	1.18494980862281	ACTB/BMP4/MED14/PFKL/PRKACB/ACTG1/AKT1/TP53/PIK3CD/MAP2K2/PIK3R2/GATA4/MAPK3/MED30/MED24/MED16/KAT2A/THRA/RXRB/BAD/HRAS	0.847653924282855
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	8/1362	41/9376	1.34321836610437	BABAM1/MRE11/ATM/ABRAXAS1/SSBP1/MUS81/PALB2/RPA3	0.907935107932136
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/1362	41/9376	1.34321836610437	TP53/MAP2K2/MMP9/CDK4/MAPK3/MMP1/HRAS/FGFR3	0.907935107932136
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	29/1362	174/9376	1.14733235438081	DNAJA2/UBXN1/SEC23B/SEC61A1/ERLEC1/MAN1B1/LMAN1/UBE2J2/DERL2/DDOST/SEC23A/ATF6B/SSR2/ERP29/STT3A/PDIA4/UBE2D4/UBXN6/CAPN1/UGGT2/KRTCAP2/MOGS/BAK1/TXNDC5/OSTC/UBXN8/MAN1C1/PREB/TUSC3	0.808688303239582
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	19/1362	110/9376	1.18905353090375	PFKL/EIF4E2/AKT1/ANGPT1/PIK3CD/PDHA1/MAP2K2/EGLN2/ALDOA/PIK3R2/RPS6KB2/PDHB/MAPK3/MKNK1/EIF4EBP1/ARNT/ANGPT2/LDHB/CYBB	0.822213324575968
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	19/1362	110/9376	1.18905353090375	DCN/BMP5/PITX2/BMP4/PPP2CB/THSD4/ACVR2A/RPS6KB2/IGSF1/E2F4/MAPK3/FST/SMAD5/NRROS/FMOD/SMAD6/RBL1/SMAD9/HFE	0.822213324575968
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	38/1362	233/9376	1.12271148840698	COL3A1/DCN/LAMA2/COL1A1/COL1A2/ACTB/FBLN1/NEBL/COL6A1/COL6A2/LBR/COL5A2/COL11A1/COL5A1/ACTG1/ELN/COL4A1/FBLN2/TNNT3/VCL/FHL3/FHL1/TNNI2/ANK2/PDLIM2/TNNT2/SGCE/VCAN/LMNB2/FHL2/SUN1/ITGA7/ITGA6/TNNT1/COL4A2/ITGA9/SYNE2/CSRP2	0.781930849009875
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	22/1362	130/9376	1.16498362137129	COL3A1/COL1A1/COL1A2/GNGT1/PRKACB/GNG11/AKT1/PIK3CD/SHC1/MAP2K2/COL4A1/ATF6B/PIK3R2/MMP9/MAPK3/GNAI1/GNB2/EDNRB/MMP1/CREB3L1/COL4A2/HRAS	0.780881414815348
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	13/1362	73/9376	1.22591676221511	CHMP4A/VPS4A/NELFE/FURIN/APOBEC3C/PIN1/APOBEC3G/SMARCB1/RAN/CHMP6/MLLT1/KAT2A/NELFA	0.798818101789148
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	18/1362	105/9376	1.18011327879169	PHB2/TP53/NBR1/UBA52/FKBP8/SAMM50/RPS27A/MUL1/GABARAPL2/MTX1/ATG9A/FIS1/CCZ1B/RRAS/PGAM5/TOMM40/FUNDC1/HRAS	0.765114819963145
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1362	18/9376	1.52977647250775	MMADHC/THAP11/MMAB/MMAA	0.927442347954683
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/1362	24/9376	1.43416544297602	B3GAT3/GLCE/B3GALT6/B4GALT7/EXTL2	0.877926479018584
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/1362	30/9376	1.37679882525698	SHMT1/IKBKG/ATIC/SHMT2/FOLR2/DHFR	0.852131857680853
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	28/1362	170/9376	1.13383432668221	WNT2/ACTB/HGF/ACTG1/IGF2/AKT1/TP53/PIK3CD/SMARCD2/SHC1/MAP2K2/PIK3R2/RPS6KB2/KEAP1/CDK4/SMARCB1/SMARCD1/MAPK3/TXNRD2/MGST2/BAK1/LEF1/BAD/ACTL6A/LRP6/DVL1/HRAS/GSTM4	0.725948841789108
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	14/1362	80/9376	1.20469897209985	PDGFRA/HGF/EIF4E2/AKT1/PIK3CD/SHC1/MAP2K2/PIK3R2/RPS6KB2/MAPK3/EIF4EBP1/BAD/HRAS/FGFR3	0.757987634455554
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	23/1362	138/9376	1.14733235438081	ACTB/ACTG1/ARPC5L/AKT1/ARPC1A/PIK3CD/MAP2K2/PKN2/IRAK4/IRF3/PIK3R2/GIT2/CRKL/IKBKG/NLRC4/NFATC2/MAPK3/CCL2/RAC2/PYCARD/ARPC4/ROCK2/DOCK1	0.718783693677424
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	16/1362	93/9376	1.18434307548987	ACTB/LMO7/CCM2/ACTG1/ACP1/VCL/PARD3/KRIT1/TJP1/NLK/MAPK3/RAC2/CDH5/LEF1/ROCK2/SSX2IP	0.736501525562958
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	38/1362	238/9376	1.09912511260011	GNGT1/PDGFRA/PLAAT3/HGF/PRKACB/IGF2/GNG11/AKT1/ANGPT1/PIK3CD/RALGAPB/FGF7/SHC1/MAP2K2/PIK3R2/PLA2G2A/EFNA5/IKBKG/RALGAPA2/MAPK3/FGF10/BDNF/RASA1/RAC2/CALM2/ANGPT2/GNB2/RGL1/CSF1R/PLA2G12A/BAD/RGL2/RRAS/PLD1/PAK4/HRAS/KITLG/FGFR3	0.638551777663579
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	13/1362	75/9376	1.19322564855605	AKT1/TP53/PIK3CD/XPA/PIK3R2/ATM/MAPK3/MGST2/BAK1/BAD/MSH2/BBC3/GSTM4	0.692596202708258
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1362	13/9376	1.58861402914266	MRE11/LIG4/POLL	0.87547610354637
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	37/1362	232/9376	1.09787837358854	TMSB4X/C7/ACTB/PDGFRA/PPP1CC/ACTG1/ARPC5L/AKT1/ARPC1A/PIK3CD/FGF7/MAP2K2/PIK3R2/CRKL/VCL/ENAH/BRK1/PPP1CA/GIT1/MAPK3/FGF10/RAC2/PIP4K2B/ARPC4/ITGA7/ITGA6/ROCK2/ITGAE/DOCK1/PIP4K2C/RRAS/PAK4/HRAS/ITGA9/LPAR5/FGFR3/SCIN	0.622317696441843
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	17/1362	101/9376	1.15869208066181	COL3A1/COL1A1/COL1A2/AKT1/PIK3CD/VCAM1/COL4A1/PIK3R2/PIM1/F3/CDK4/MAPK3/CCL2/AGTR1/CYBB/COL4A2/HRAS	0.661010723478432
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	11/1362	63/9376	1.20196722839895	PTGDS/HPGDS/PLAAT3/CBR1/LTC4S/PLA2G2A/HPGD/PTGR1/PTGES2/PLA2G12A/CBR3	0.663064691081872
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/1362	70/9376	1.18011327879169	HGF/AKT1/PIK3CD/MAP2K2/EGLN2/PIK3R2/CRKL/MAPK3/ARNT/BAD/PAK4/HRAS	0.623537749357821
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/1362	32/9376	1.29074889867841	PPP2CB/ATG4C/GABARAPL2/ATG9A/MLST8/ATG4D	0.679166374028823
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/1362	51/9376	1.2148224928738	ACTB/SEC61A1/PRKACB/ACTG1/PDIA4/TJP1/ATP6V1E2/ATP6V0E2/ATP6V1G1	0.634147000698606
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	23/1362	142/9376	1.11501313313065	ACTB/BMP4/ACTG1/AKT1/TP53/PIK3CD/SUMO1/VCAM1/ACVR2A/PIK3R2/KEAP1/MMP9/IKBKG/CCL2/RAC2/CDH5/CALM2/MGST2/TXN2/TNFRSF1A/CAV1/PIAS4/GSTM4	0.56930656831671
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/1362	103/9376	1.13619320530915	COL3A1/LAMA2/COL1A1/COL1A2/LAMC1/PRKACB/PIK3CD/LAMC3/SERPINB6/COL4A1/PIK3R2/VCL/CD14/LAMA4/ARG2/GNA14/COL4A2	0.572945676473296
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	15/1362	90/9376	1.14733235438081	PRKACB/EIF4E2/AKT1/TP53/PIK3CD/STK11/SESN3/ATF6B/PIK3R2/RPS6KB2/EIF4EBP1/EHMT2/IRS1/CREB3L1/HRAS	0.578968008465575
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1362	14/9376	1.47514159848962	B4GALT3/FUT8/ST3GAL3	0.733419202944879
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	11/1362	65/9376	1.16498362137129	ALDH9A1/PLPP3/DGKZ/PLPP5/AKR1B1/ABHD16A/AGPAT2/AKR1A1/ALDH7A1/DGKH/AGK	0.550235833627483
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	32/1362	204/9376	1.07984221588782	DCN/LUM/COL1A1/GPC3/WNT2/COL1A2/ACTB/TIMP3/HGF/PPP1CC/PRKACB/TWIST1/ACTG1/IGF2/AKT1/TP53/PIK3CD/MAP2K2/PIK3R2/CD63/RPS6KB2/VTN/MMP9/PPP1CA/MAPK3/ANK2/CAV1/NUDT16L1/ROCK2/RRAS/DROSHA/HRAS	0.47529710078023
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/1362	59/9376	1.16677866547201	PRKG1/PLAAT3/PRKACB/AKT1/PIK3CD/CGA/PIK3R2/IRS1/GNAI1/ADRB1	0.529758550846033
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/1362	59/9376	1.16677866547201	AKT1/TP53/PIK3CD/MAP2K2/PIK3R2/MAPK3/BAK1/LEF1/BAD/HRAS	0.529758550846033
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	25/1362	158/9376	1.08923957694381	WNT2/EIF4E2/AKT1/RICTOR/PIK3CD/STK11/MAP2K2/SEH1L/PIK3R2/LAMTOR1/RPS6KB2/RRAGA/MAPK3/ATP6V1E2/EIF4EBP1/TTI1/IRS1/TNFRSF1A/MLST8/LRP6/DEPTOR/DVL1/ATP6V1G1/HRAS/SLC38A9	0.466355622709945
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	5/1362	27/9376	1.27481372708979	ELOVL2/HSD17B12/ELOVL1/SCP2/HACD3	0.589504666485894
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	16/1362	99/9376	1.11256470727836	PLPP3/PDGFRA/AKT1/DGKZ/PIK3CD/LYPLA1/MAP2K2/SLC22A3/PIK3R2/RPS6KB2/MAPK3/RAC2/EIF4EBP1/PLD1/HRAS/DGKH	0.464157730794843
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1362	21/9376	1.31123697643521	B3GAT3/B3GALT6/B4GALT7/CHSY3	0.588611119353096
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/1362	60/9376	1.14733235438081	AKT1/PIK3CD/MAP2K2/PIK3R2/NFATC2/MAPK3/RAC2/SPHK2/BAD/HRAS	0.471963634798171
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	14/1362	87/9376	1.10776916974699	AKT1/TP53/PIK3CD/MAP2K2/PIK3R2/RPS6KB2/MAPK3/RAC2/BAK1/LEF1/BAD/MSH2/BBC3/HRAS	0.416312264067781
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/1362	35/9376	1.18011327879169	PFKL/AKR1B1/ALDOA/FBP1/PMM1/MPI	0.440080972131123
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1362	22/9376	1.25163529568816	ALDH9A1/ALDH3B1/AOC1/ALDH7A1	0.487117506599013
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	17/1362	109/9376	1.07365046006278	CD36/SLC27A4/PPP1CC/AKT1/PIK3CD/PTPA/PIK3R2/G6PC3/RPS6KB2/PPARA/PPP1CA/CRTC2/PYGL/IRS1/TNFRSF1A/CREB3L1/SLC27A5	0.318836956188055
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	50/1362	333/9376	1.03363275169443	SPP1/LAMA2/COL1A1/WNT2/COL1A2/COL6A1/COL6A2/MAGI1/LAMC1/RBPJ/PPP2CB/PRKACB/CCND2/RBL2/AKT1/TP53/PIK3CD/LAMC3/MAP2K2/COL4A1/IRF3/PIK3R2/ATM/RPS6KB2/PARD3/TBPL1/MFNG/VTN/IKBKG/CDK4/MAPK3/ATP6V1E2/PPP2R5D/EIF4EBP1/LAMA4/BAK1/TNFRSF1A/ITGA7/ITGA6/BAD/DVL1/ATP6V0E2/CREB3L1/ATP6V1G1/DLG1/COL4A2/HRAS/RBL1/ITGA9/PPP2R3B	0.257618931869622
Human Diseases	Cancer: specific types	hsa05214	Glioma	12/1362	76/9376	1.08694644099235	PDGFRA/AKT1/TP53/PIK3CD/SHC1/MAP2K2/PIK3R2/CDK4/MAPK3/CALM2/BAK1/HRAS	0.313737660959396
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/1362	103/9376	1.0693583108792	COL3A1/COL1A1/COL14A1/COL1A2/COL15A1/COL6A1/COL6A2/COL5A2/COL11A1/COL21A1/COL5A1/DPP4/ELN/COL4A1/KCNE3/COL4A2	0.291780667438772
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	22/1362	144/9376	1.05172132484908	WNT2/BMP4/PCGF3/AKT1/IL6ST/PIK3CD/MAP2K2/JAK3/ACVR2A/PIK3R2/TCF3/MAPK3/MEIS1/SMARCAD1/SMAD5/DUSP9/LIFR/DVL1/HRAS/PCGF6/SMAD9/FGFR3	0.257841317683485
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/1362	23/9376	1.19721636978867	B4GALT3/ST3GAL3/POMT1/POMGNT1	0.390374044418643
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1362	23/9376	1.19721636978867	NLN/AGTR1/ENPEP/THOP1	0.390374044418643
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/1362	50/9376	1.10143906020558	HBA2/HBA1/HBB/CD36/HGF/VCAM1/CCL2/ACKR1	0.296477702520151
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/1362	77/9376	1.07283025344699	AKT1/TP53/PIK3CD/PIK3R2/RPS6KB2/IKBKG/CDK4/MAPK3/RAC2/BAK1/BAD/PLD1	0.264538315009977
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	21/1362	138/9376	1.04756432356509	PPP1CC/PRKACB/EIF4E2/AKT1/PIK3CD/SHC1/MAP2K2/PIK3R2/G6PC3/RPS6KB2/CRKL/PPP1CA/MAPK3/MKNK1/EIF4EBP1/CALM2/PYGL/IRS1/FBP1/BAD/HRAS	0.232049914107908
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/1362	37/9376	1.11632337182998	HBA2/HBA1/HBB/VCAM1/LAMA4/THOP1	0.292258519354978
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	15/1362	98/9376	1.05367257034973	PLPP3/ARPC5L/AKT1/ARPC1A/PIK3CD/PIK3R2/RPS6KB2/CRKL/MAPK3/RAC2/SPHK2/ARPC4/DOCK1/PLD1/SCIN	0.220185020820878
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1362	17/9376	1.2148224928738	SCP2/ACOT8/SLC27A5	0.365459294892694
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	11/1362	71/9376	1.0665343012554	CCND2/AKT1/PIK3CD/PRLR/SHC1/MAP2K2/CGA/PIK3R2/TNFRSF11A/MAPK3/HRAS	0.23198831411154
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	28/1362	187/9376	1.03075847880201	VDAC2/CARD8/CARD16/VDAC1/TP53BP1/TRIP6/PKN2/IRAK4/ANTXR1/IRF3/MAVS/SHARPIN/VDAC3/IKBKG/NLRC4/MAPK3/CCL2/CARD9/PYCARD/TXN2/GSDMD/GABARAPL2/RNASEL/PSTPIP1/RIPK3/YWHAE/CYBB/DHX33	0.17514633482374
NA	NA	hsa04517	IgSF CAM signaling	44/1362	299/9376	1.01302923597503	SLIT2/PTPRD/ACTB/CADM3/MAGI1/LMO7/IL1RAPL1/NRCAM/ICAM2/ACTG1/ARPC5L/ROBO2/AKT1/ARPC1A/MPDZ/NFASC/PIK3CD/ROBO1/MYL6/MAP2K2/CLMP/PLXNA1/CASK/PIK3R2/UNC5C/DOK2/VCL/PARD3/CABLES1/TJP1/PLXNA2/GIT1/MAPK3/TUBB2A/ANK2/RASA1/KIRREL1/MYL6B/SLIT3/ARPC4/DOK1/PMP22/PAK4/SSX2IP	0.0943915024978992
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/1362	52/9376	1.05907601942844	CD36/PLTP/APOC1/VDAC2/VDAC1/VDAC3/APOE/LDLRAP1	0.176100782999173
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	9/1362	59/9376	1.05010079892481	HPGDS/IDH2/IDH1/GSS/GGCT/MGST2/SRM/LANCL1/GSTM4	0.15914101818431
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	25/1362	170/9376	1.01235207739483	ACTB/MAGI1/PPP2CB/PRKACB/ACTG1/ARPC5L/ARPC1A/MPDZ/STK11/MYL6/NF2/GATA4/PARD3/CDK4/TJP1/CGNL1/MYL6B/PCNA/ARPC4/ROCK2/DLG1/RAB13/EPB41L4B/AMOTL2/CLDN11	0.0670005707860088
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	18/1362	122/9376	1.01567126453383	CD36/RAB14/PPP2CB/PFKL/AKT1/PIK3CD/STK11/PIK3R2/G6PC3/RPS6KB2/CRTC2/PPP2R5D/EIF4EBP1/IRS1/FBP1/MLYCD/CREB3L1/PPP2R3B	0.0718238584808198
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	30/1362	205/9376	1.00741377457827	RBPJ/PRKACB/CCND2/RBL2/IL6ST/TP53/PIK3CD/JAK3/ATF6B/IRF3/VDAC3/PIK3R2/TBPL1/IKBKG/CDK4/MRPS18B/MAPK3/HDAC7/GTF2A2/BAK1/KAT2A/HDAC10/DNAJA3/BAD/YWHAE/CREB3L1/DLG1/HRAS/RBL1/SCIN	0.0442443158068085
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	31/1362	212/9376	1.00662178261713	ACTB/MAGI1/PDGFRA/HGF/ACTG1/AKT1/ANGPT1/PIK3CD/FGF7/SIPA1/MAP2K2/EVL/PIK3R2/EFNA5/CRKL/PARD3/ENAH/KRIT1/MAPK3/FGF10/RAC2/CALM2/PRKD1/ANGPT2/GNAI1/CSF1R/RRAS/HRAS/LPAR5/KITLG/FGFR3	0.0402022011836175
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	23/1362	157/9376	1.00848321595256	CD36/RAB14/DNMT3A/VPS39/CASP7/S1PR1/MAP2K2/STAB1/PLA2G15/BSG/CRKL/NFATC2/MAPK3/VPS33A/VPS16/ARNT/GULP1/SPHK2/ARG2/CX3CR1/DOCK1/SLC66A1/SIRPB1	0.0441893857149989
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/1362	33/9376	1.04302941307347	VTI1B/YKT6/USE1/GOSR2/STX2	0.102077198119635
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	8/1362	54/9376	1.01985098167183	POLI/MUS81/FAN1/ATRIP/PALB2/FAAP100/RPA3/FANCD2	0.0603078494404154
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	12/1362	82/9376	1.00741377457827	HPRT1/NME3/ITPA/TK2/IMPDH1/DUT/CES2/NME1/NME6/MGST2/NME4/GSTM4	0.0277967801314617
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	16/1362	110/9376	1.00130823655053	CDC26/PRKACB/ANAPC10/AKT1/PIK3CD/ANAPC16/PIK3R2/ANAPC15/CDC16/ANAPC4/MAPK3/MAD2L2/ANAPC11/GNAI1/CDC23/ANAPC1	0.0056896558260446
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	20/1362	138/9376	0.997680308157228	PPP2CB/PPP1CC/CDC26/PRKACB/SMC3/ANAPC10/ANAPC16/ANAPC15/CDC16/ANAPC4/PPP1CA/MAPK3/MAD2L2/ANAPC11/PPP2R5D/CALM2/PTTG1/CDC23/ANAPC1/YWHAE	-0.0113169756768507
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	9/1362	62/9376	0.999289469944579	RBPJ/APH1A/NCSTN/CIR1/PSENEN/MFNG/CTBP1/KAT2A/DVL1	-0.00231398054999931
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	8/1362	55/9376	1.00130823655053	PLPP3/CERS2/GLB1/DEGS1/SGPP1/SGMS1/SPHK2/SMPD1	0.00401130691615231
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/1362	27/9376	1.01985098167183	HMGCLL1/ECHS1/HADH/ACADS	0.0425824665084803
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	19/1362	133/9376	0.983427732326411	HOMER3/CCND2/RBL2/AKT1/PIK3CD/STK11/S1PR1/PRMT1/MAP2K2/PIK3R2/ATM/G6PC3/NLK/MAPK3/FBXO25/IRS1/GABARAPL2/CCNG2/HRAS	-0.0793507080373682
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/1362	42/9376	0.983427732326411	VDAC2/TP53/GSS/NCOA4/VDAC3/CYBB	-0.0443733491702825
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	15/1362	106/9376	0.974150112210124	PDGFRA/AKT1/TP53/PIK3CD/MAP2K2/PIK3R2/MMP9/IKBKG/ETV5/MAPK3/LEF1/BAD/CREB3L1/FOLR2/HRAS	-0.110337020113859
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	11/1362	78/9376	0.970819684476072	C4BPB/CASP7/C1S/IRAK4/IRF3/MAPK3/CD14/CALM2/C2/PYCARD/GNAI1	-0.106682218128345
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	15/1362	107/9376	0.965045905553954	PFKL/PRKACB/AKT1/PPP4C/PRMT1/PDHA1/G6PC3/PPARA/PDHB/CRTC2/CALM2/PYGL/FBP1/LDHB/CREB3L1	-0.149907384212497
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/1362	50/9376	0.963759177679883	ALDH9A1/GATM/PYCR2/AOC1/ARG2/SRM/ALDH7A1	-0.105921680634009
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/1362	86/9376	0.960557319946727	AKT1/PIK3CD/SHC1/MAP2K2/PIK3R2/RPS6KB2/CRKL/MAPK3/EIF4EBP1/BAD/PAK4/HRAS	-0.151480701726691
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/1362	43/9376	0.960557319946727	CD36/SLC27A4/PLPP3/AGPAT2/PLA2G2A/PLA2G12A	-0.106865995207076
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/1362	36/9376	0.956110295317344	ENPP1/PGM2/G6PC3/PYGL/GANC	-0.108765207784765
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/1362	65/9376	0.953168417485598	SPP1/AKT1/PIK3CD/MAP2K2/CGA/PIK3R2/MAPK3/KCNJ5/HRAS	-0.156187715063641
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	14/1362	101/9376	0.954217007603844	WNT2/PRKACB/MAP2K2/MAPK3/CALM2/GNAI1/LEF1/EDNRB/MC1R/ASIP/DVL1/CREB3L1/HRAS/KITLG	-0.190702956320072
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	16/1362	116/9376	0.949516431211707	ACTB/ACTG1/PIK3CD/SIPA1/VCAM1/NCF4/PIK3R2/VCL/MMP9/RAC2/CDH5/GNAI1/ROCK2/CYBB/ARHGAP5/CLDN11	-0.225539738579648
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	23/1362	166/9376	0.953806415087664	PRKG1/PDE3A/VDAC2/PPP1CC/AKT1/VDAC1/MAP2K2/ATF6B/VDAC3/GUCY1A2/GATA4/PPP1CA/NFATC2/MAPK3/CALM2/AGTR1/IRS1/GNAI1/EDNRB/ROCK2/BAD/CREB3L1/ADRB1	-0.247545718574942
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/1362	37/9376	0.930269476524983	ALDH3B1/GSTZ1/ADH5/COMT/FAHD1	-0.175195570967826
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	12/1362	89/9376	0.928178983319309	PRKG1/GJA1/PDGFRA/PRKACB/MAP2K2/GUCY1A2/TJP1/MAPK3/TUBB2A/GNAI1/ADRB1/HRAS	-0.280645673931081
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1362	15/9376	0.91786588350465	ACP1/NTPCR	-0.131237400574217
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1362	38/9376	0.905788700826957	ENPP1/NMRK1/NNT/NT5C/QPRT	-0.239892891526592
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/1362	38/9376	0.905788700826957	PIK3CD/PIK3R2/MAPK3/HSD11B2/IRS1	-0.239892891526592
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	18/1362	133/9376	0.931668377993442	GNGT1/PPP2CB/PPP1CC/PRKACB/GNG11/AKT1/CLOCK/ATF6B/PPP1CA/COMT/PPP2R5D/GRIA4/CALM2/GNAI1/GNB2/KCNJ5/CREB3L1/PPP2R3B	-0.327182899429228
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/1362	97/9376	0.922597150945396	PRKG1/GNGT1/RYR2/PRKACB/GNG11/GUCY1A2/MAPK3/GRIA4/CALM2/GNAI1/GNB2/KCNJ5/GRIN2C	-0.315894270684945
Organismal Systems	Immune system	hsa04611	Platelet activation	17/1362	126/9376	0.928792858308277	COL3A1/COL1A1/PRKG1/COL1A2/ACTB/PPP1CC/PRKACB/ACTG1/FERMT3/AKT1/PIK3CD/PIK3R2/GUCY1A2/PPP1CA/MAPK3/GNAI1/ROCK2	-0.331732088051357
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	28/1362	205/9376	0.940252856273056	PSMD11/RBPJ/ADRM1/PSMD4/PSMC4/PSMD2/PSMC5/PSMC2/CCND2/PSMC6/PSMD6/AKT1/TP53/PIK3CD/PSMD13/CIR1/PSMD3/PSMC3/JAK3/IRAK4/IRF3/MAVS/PSMD8/PIK3R2/IKBKG/CDK4/BAK1/SAP30L	-0.356562162458542
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/1362	46/9376	0.897912277341505	UROS/HMOX2/ALAS2/UROD/MMAB/FECH	-0.286128509620629
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1362	31/9376	0.888257306617403	ALDH9A1/AKR1A1/UGDH/ALDH7A1	-0.256897484733455
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/1362	76/9376	0.905788700826957	CD36/PLTP/SLC27A4/SCP2/ACADM/PPARA/CPT2/RXRB/MMP1/SLC27A5	-0.339952185519558
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	20/1362	149/9376	0.924026057219446	PLPP3/PDGFRA/AKT1/DGKZ/PIK3CD/SHC1/MAP2K2/PIK3R2/AGPAT2/MAPK3/AGTR1/SPHK2/PTGFR/DNM3/RRAS/PLD1/HRAS/LPAR5/DGKH/KITLG	-0.385369253908729
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	24/1362	178/9376	0.928178983319309	WNT2/RSPO2/PRICKLE1/MMP7/PRKACB/CCND2/RYK/TP53/RSPO3/RUVBL1/INVS/FRZB/NOTUM/CTBP1/SERPINF1/NLK/NFATC2/RAC2/MCC/LEF1/ROCK2/LRP6/DVL1/ROR1	-0.398808466947754
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	13/1362	99/9376	0.903958824663671	PRKACB/AKT1/TP53/PIK3CD/SHC1/MAP2K2/PIK3R2/RPS6KB2/MMP9/CDK4/MAPK3/BAD/HRAS	-0.396023363670656
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1362	16/9376	0.860499265785609	NAGA/B3GALNT1	-0.230222668381827
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/1362	32/9376	0.860499265785609	CASP7/BAK1/TNFRSF1A/BBC3	-0.325862654205749
Cellular Processes	Cell motility	hsa04814	Motor proteins	26/1362	194/9376	0.922597150945396	ACTB/ACTG1/DYNLT1/DCTN2/DYNC1I2/MYL6/KIFAP3/DCTN3/TNNT3/DCTN6/TNNI2/MYO1B/DYNLRB1/MYO1C/TUBB2A/ACTR10/KIF1C/TNNT2/MYL6B/KIF26B/KIF3B/KIF18A/DNAH8/TNNT1/DNAL1/KIF14	-0.449095486396404
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	9/1362	70/9376	0.88508495909377	CD36/AKT1/STK11/G6PC3/PPARA/IKBKG/IRS1/TNFRSF1A/RXRB	-0.397826670275116
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	29/1362	216/9376	0.924239952140099	CD36/AKT1/TP53/PIK3CD/CASP7/VCAM1/NCF4/IRAK4/IRF3/PIK3R2/HSPA2/MMP9/IKBKG/NFATC2/MAPK3/CCL2/CD14/CALM2/MIB2/PYCARD/TNFRSF1A/RXRB/ROCK2/MMP1/MIB1/BAD/CASP6/CYBB/HRAS	-0.46437507584176
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	8/1362	63/9376	0.874157984290143	WNT2/BMP4/TP53/GLI3/GLI2/BAK1/LEF1/DVL1	-0.413143250681019
NA	NA	hsa03272	Virion - Hepatitis viruses	6/1362	48/9376	0.860499265785609	CHMP4A/VPS4A/DPP4/CD63/CHMP7/CLDN11	-0.399440747982302
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	34/1362	253/9376	0.925121740291248	ACTB/ACTG1/ARPC5L/AKT1/ARPC1A/TP53/PIK3CD/VDAC1/IRF3/SHARPIN/PIK3R2/ATM/SEPTIN11/UBA52/RPS6KB2/CRKL/VCL/RRAGA/IKBKG/NLRC4/UBE2D4/MAPK3/RPS27A/CAPN1/CD14/SEPTIN7/TECPR1/PYCARD/TNFRSF1A/ARPC4/ROCK2/DOCK1/GLMN/TIFA	-0.497733289445666
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/1362	86/9376	0.880510876617833	LAMA2/ACTB/RYR2/GJA1/ACTG1/CACNA2D4/SGCE/ITGA7/LEF1/ITGA6/ITGA9	-0.458901277352114
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1362	49/9376	0.842938056279781	PRKACB/ATF6B/BDNF/GNAI1/CREB3L1/GRIN2C	-0.45440964655322
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/1362	34/9376	0.809881661915868	FBXL3/CLOCK/BHLHE41/DBP	-0.457818206032208
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	18/1362	140/9376	0.88508495909377	SPP1/GNGT1/RYR2/PRKACB/TFAM/GNG11/AKT1/MAP2K2/RPS6KB2/CCN2/MAPK3/CALM2/AGTR1/GNAI1/GNB2/SPHK2/RRAS/HRAS	-0.564739876665526
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1362	26/9376	0.794307014571332	PLAAT3/PLA2G2A/PLA2G12A	-0.432962091704795
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	28/1362	214/9376	0.900709511850357	GNGT1/CUL5/GNG11/AKT1/RNF7/PIK3CD/APOBEC3C/MAP2K2/IRAK4/IRF3/APOBEC3G/PIK3R2/ATM/RPS6KB2/CRKL/IKBKG/NFATC2/MAPK3/RAC2/CALM2/GNAI1/GNB2/BAK1/TNFRSF1A/BAD/PAK4/HRAS/AP1G2	-0.605715813163603
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1362	18/9376	0.764888236253875	HSD17B8/CBR4	-0.411593601294333
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/1362	18/9376	0.764888236253875	FUCA1/GLB1	-0.411593601294333
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	15/1362	119/9376	0.867730352052715	AKT1/PIK3CD/CASP7/VCAM1/ATF6B/PIK3R2/BAG4/MMP9/IKBKG/MAPK3/CCL2/TNFRSF1A/RIPK3/PGAM5/CREB3L1	-0.598615653709703
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	15/1362	120/9376	0.860499265785609	AKT1/TP53/PIK3CD/SHC1/MAP2K2/IRAK4/PIK3R2/CRKL/MAPK3/BDNF/CALM2/IRS1/BAD/YWHAE/HRAS	-0.634022932274738
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	19/1362	150/9376	0.871972589329418	WNT2/RARB/HGF/AKT1/TP53/PIK3CD/FGF7/SHC1/MAP2K2/PIK3R2/RPS6KB2/MAPK3/FGF10/BAK1/RXRB/LEF1/LRP6/DVL1/HRAS	-0.651615474572726
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/1362	67/9376	0.821969447914612	PPP1CC/PRKACB/MAP2K2/PPP1CA/MAPK3/CALM2/HRAS/GRIN2C	-0.602878710355388
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	23/1362	180/9376	0.879621471691956	PPP1CC/SRSF1/AKT1/TP53/PIK3CD/IRAK4/IRF3/MAVS/PIK3R2/IKBKG/PPP1CA/EIF2B1/ALYREF/CCL2/EIF4EBP1/CARD9/SRSF9/RNASEL/BAK1/SRSF8/TNFRSF1A/BAD/EIF2B4	-0.672256985513479
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	22/1362	173/9376	0.875421218371487	ACTB/ACTG1/AKT1/FDPS/PIK3CD/VDAC1/MAP2K2/RAE1/IRAK4/IRF3/MAVS/PIK3R2/PABPN1/IKBKG/CDK4/MAPK3/CCL2/PYCARD/RNASEL/BAK1/TNFRSF1A/CPSF4	-0.681792065426647
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	10/1362	83/9376	0.829396882684925	RBBP7/PCGF3/UBE2D4/L3MBTL2/BCORL1/CBX7/L3MBTL3/BAP1/PCGF6/WDR5	-0.64357262552202
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1362	19/9376	0.724630960661566	GLB1/NAGLU	-0.495305463089614
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/1362	44/9376	0.7822720598051	PRKACB/DCTN2/DYNC1I2/DCTN6/CREB3L1	-0.596764060192856
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/1362	60/9376	0.803132648066569	PRKG1/PPP2CB/MAP2K2/GUCY1A2/MAPK3/GNAI1/HRAS	-0.630643767162208
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1362	36/9376	0.764888236253875	DCXR/AKR1B1/AKR1A1/UGDH	-0.582641875159281
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1362	28/9376	0.737570799244808	B4GALT3/B3GALNT1/ST3GAL3	-0.573299211577802
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/1362	28/9376	0.737570799244808	ATP6V1E2/ATP6V0E2/ATP6V1G1	-0.573299211577802
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	15/1362	122/9376	0.846392720444862	IGFBP3/PRKACB/AKT1/PIK3CD/CSH1/SHC1/MAP2K2/ATF6B/PIK3R2/CRKL/MAPK3/IRS1/GNAI1/CREB3L1/HRAS	-0.704006207321215
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/1362	69/9376	0.798144246525783	AKT1/PIK3CD/MAP2K2/PIK3R2/MAPK3/RAC2/HRAS/ALOX5AP	-0.693761737603928
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/1362	69/9376	0.798144246525783	PPP1CC/PRKACB/ATF6B/PPP1CA/GRIA4/CALM2/CREB3L1/GRIN2C	-0.693761737603928
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	21/1362	168/9376	0.860499265785609	CHMP4A/VPS4A/PARP1/VDAC2/VDAC1/CHMP2A/CHMP5/JAK3/SHARPIN/VDAC3/CAPN1/CHMP6/CHMP7/PYGL/PYCARD/SPATA2/TNFRSF1A/RIPK3/SMPD1/CYBB/PGAM5	-0.752138815587153
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1362	20/9376	0.688399412628488	LBR/EBP	-0.575065987517866
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1362	20/9376	0.688399412628488	UAP1L1/UGDH	-0.575065987517866
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/1362	29/9376	0.71213732340878	YAP1/NF2/FAT4	-0.640026210619904
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	7/1362	62/9376	0.777225143290228	PRKACB/AKT1/PIK3CD/PIK3R2/RPS6KB2/IRS1/HRAS	-0.725510035109702
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	19/1362	156/9376	0.838435182047517	PPP2CB/AKT1/TP53/PIK3CD/MAP2K2/IRF3/MAVS/PIK3R2/PPARA/IKBKG/CDK4/MAPK3/RNASEL/BAK1/TNFRSF1A/BAD/YWHAE/HRAS/CLDN11	-0.838867090906967
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/1362	79/9376	0.784252495399543	SYT1/AP2A1/STX2/AP2M1/ATP6V1E2/DNM3/ATP6V0E2/ATP6V1G1/CLTC	-0.793848145086126
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1362	30/9376	0.688399412628488	PLAAT3/PLA2G2A/PLA2G12A	-0.704685815276216
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	19/1362	157/9376	0.833094830569507	BMP5/WNT2/ACTB/BMP4/PPP2CB/PPP1CC/ACTG1/CCND2/YAP1/NF2/PARD3/PPP1CA/CCN2/GLI2/LEF1/YWHAE/BBC3/DVL1/DLG1	-0.869415201856838
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/1362	56/9376	0.737570799244808	PRKACB/CCND2/GAS1/GLI3/CDON/GLI2	-0.811984498082443
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/1362	48/9376	0.717082721488008	AKT1/PIK3CD/PIK3R2/G6PC3/SLC37A4	-0.810093867837791
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	28/1362	227/9376	0.849127028792848	GNGT1/PDGFRA/PRKACB/GNG11/AKT1/TP53/PIK3CD/MAP2K2/ATF6B/IRF3/PIK3R2/RPS6KB2/CRKL/IKBKG/CDK4/NFATC2/MAPK3/CCL2/RAC2/EIF4EBP1/CALM2/GNAI1/GNB2/BAK1/TNFRSF1A/ROCK2/CREB3L1/HRAS	-0.948608650906242
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	12/1362	105/9376	0.786742185861129	LAMA2/ACTB/RYR2/PRKACB/ACTG1/CACNA2D4/TNNT2/SGCE/ITGA7/ITGA6/ADRB1/ITGA9	-0.905911630531718
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	10/1362	90/9376	0.764888236253875	AKT1/PIK3CD/MAP2K2/PIK3R2/RPS6KB2/IKBKG/NFATC2/MAPK3/BATF/HRAS	-0.923912403321034
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	14/1362	122/9376	0.789966539081871	PPP2CB/AKT1/PIK3CD/MAP2K2/PIK3R2/IKBKG/CDK4/NFATC2/MAPK3/PPP2R5D/PAK4/DLG1/HRAS/PPP2R3B	-0.962616229255226
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	4/1362	41/9376	0.671609183052183	GRIA4/GABRA3/GABRR2/GRIN2C	-0.868710946950825
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	18/1362	154/9376	0.804622690085245	ACTB/RYR2/PPP1CC/PRKACB/ACTG1/MYL6/MAP2K2/CACNA2D4/GUCY1A2/PPP1CA/NFATC2/MAPK3/CALM2/MYL6B/GNAI1/KCNJ5/ROCK2/HRAS	-1.00779326127201
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/1362	139/9376	0.792402201586748	PRKACB/AKT1/PIK3CD/SHC1/MAP2K2/ATF6B/PIK3R2/MMP9/KRT18/MAPK3/CALM2/GNAI1/KRT10/KCNJ5/CREB3L1/HRAS	-1.01651594358836
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	24/1362	201/9376	0.821969447914612	IGFBP3/RUNX1T1/PROM1/CCND2/TP53/LMO2/ATM/TSPAN7/CEBPA/MMP9/HPGD/ETV5/TCF3/MAF/MEIS1/CD14/MLLT1/BAK1/LYL1/FUT8/RXRB/CSF1R/MLF1/DUSP6	-1.05181425838318
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	19/1362	163/9376	0.80242876318658	AKT1/TP53/PIK3CD/MAP2K2/JAK3/ATF6B/IRAK4/IRF3/MAVS/VDAC3/PIK3R2/MMP9/IKBKG/NFATC2/MAPK3/PCNA/BAD/CREB3L1/HRAS	-1.04897830969666
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	17/1362	148/9376	0.790729055046236	WNT2/AKT1/TP53/PIK3CD/FGF7/SHC1/MAP2K2/PIK3R2/RPS6KB2/CDK4/MAPK3/FGF10/BAK1/LEF1/LRP6/DVL1/HRAS	-1.05787784795125
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/1362	69/9376	0.69837621571006	PDE3A/PRKACB/GUCY1A2/CALM2/AGTR1/GNAI1/ADRB1	-1.03665631070748
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	15/1362	134/9376	0.770596357419949	PRKG1/CALD1/PPP1CC/PRKACB/MYL6/MAP2K2/GUCY1A2/PLA2G2A/PPP1CA/MAPK3/CALM2/AGTR1/MYL6B/PLA2G12A/ROCK2	-1.10260320259158
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	11/1362	103/9376	0.735183838729453	PPP2CB/AKT1/PIK3CD/IRAK4/PIK3R2/IKBKG/MAPK3/CCL2/GNAI1/TNFRSF1A/GNA14	-1.11404437773385
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/1362	53/9376	0.649433408140083	PRKACB/AP2A1/AP2M1/DNM3/CLTC	-1.05506724928154
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8/1362	79/9376	0.697113329244038	HPGDS/CBR1/ALDH3B1/ADH5/AKR7A2/MGST2/CBR3/GSTM4	-1.11447880797609
Human Diseases	Infectious disease: viral	hsa05162	Measles	15/1362	136/9376	0.759264058046126	CCND2/AKT1/TP53/RCHY1/PIK3CD/JAK3/IRAK4/IRF3/MAVS/PIK3R2/IKBKG/CDK4/BAK1/BAD/BBC3	-1.16579966701616
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	12/1362	112/9376	0.737570799244808	LAMA2/LAMC1/AKT1/LAMC3/IRAK4/IKBKG/MAPK3/LAMA4/GNAI1/TNFRSF1A/ITGA6/BAD	-1.15178500146033
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/1362	88/9376	0.70404485382459	F13A1/SERPINE2/C7/C4BPB/C1S/F3/VTN/C2/CLU	-1.14988829099838
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/1362	45/9376	0.6119105890031	ABCB10/ABCB8/ABCB6/ABCC6	-1.0757800305344
NA	NA	hsa04519	Cadherin signaling	50/1362	404/9376	0.851979471074861	CDH11/WNT2/ACTB/GJA1/PRICKLE1/PDGFRA/PCDH10/PPP1CC/APH1A/ACTG1/ARPC5L/NCSTN/RYK/YAP1/ARPC1A/MPDZ/TMC6/TMC8/MAP2K2/EVL/PSENEN/NF2/PCDH12/VCL/ENAH/IKBKG/BRK1/PPP1CA/TJP1/KRT18/MYO1B/MYO1C/MAPK3/RAC2/PCDH18/CDH5/KRT10/KRT1/GABRA3/ARPC4/LEF1/ROCK2/YWHAE/RRAS/LRP6/DVL1/FAT4/HRAS/AMOTL2/GABRR2	-1.25376899214811
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/1362	105/9376	0.721180337039368	PARP1/UBE2I/EDA/VCAM1/IRAK4/ATM/TNFRSF11A/IKBKG/CD14/TNFRSF1A/PIAS4	-1.18441603894753
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/1362	105/9376	0.721180337039368	AKT1/PIK3CD/PIK3R2/IKBKG/NFATC2/MAPK3/CALM2/CARD9/PYCARD/RRAS/HRAS	-1.18441603894753
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	17/1362	154/9376	0.759921429524954	RYR2/PPP2CB/PPP1CC/PRKACB/AKT1/ATF6B/CACNA2D4/PPP1CA/MAPK3/PPP2R5D/CALM2/TNNT2/AGTR1/GNAI1/CREB3L1/ADRB1/PPP2R3B	-1.23837085077143
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1362	16/9376	0.430249632892805	ALDH3B1	-0.940277845601566
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/1362	98/9376	0.702448380233151	DGKZ/PIK3CD/SACM1L/CDIPT/PIK3R2/MTMR2/CALM2/PIP4K2B/PIP4K2C/DGKH	-1.22066838175907
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	26/1362	226/9376	0.791963926032773	RYR2/PDE3A/PPP1CC/PRKACB/AKT1/PIK3CD/MAP2K2/CGA/PIK3R2/VIPR2/PPARA/PPP1CA/GLI3/MAPK3/BDNF/RAC2/GRIA4/CALM2/GNAI1/ROCK2/BAD/RRAS/CREB3L1/PLD1/ADRB1/GRIN2C	-1.30506410463464
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	10/1362	99/9376	0.695352942048977	LAMA2/ACTB/RYR2/ACTG1/CACNA2D4/TNNT2/SGCE/ITGA7/ITGA6/ITGA9	-1.25620445813616
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/1362	47/9376	0.585871840534883	PIK3CD/PIK3R2/MAPK3/IRS1	-1.17331782252323
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	9/1362	91/9376	0.680834583918284	AKT1/PIK3CD/MAP2K2/PIK3R2/IKBKG/NFATC2/MAPK3/RAC2/HRAS	-1.26123231988406
Human Diseases	Substance dependence	hsa05032	Morphine addiction	9/1362	91/9376	0.680834583918284	GNGT1/PDE3A/PRKACB/GNG11/GNAI1/GNB2/KCNJ5/GABRA3/GABRR2	-1.26123231988406
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	22/1362	196/9376	0.772693218256466	GNGT1/GNG11/AKT1/IL6ST/TP53/PIK3CD/MAP2K2/IRF3/PIK3R2/UBA52/IKBKG/CDK4/NFATC2/MAPK3/RPS27A/CALM2/ANGPT2/GNB2/BAK1/TNFRSF1A/LEF1/HRAS	-1.32577129366667
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1362	38/9376	0.543473220496174	JAK3/RFXANK/IKBKG	-1.16246703055585
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1362	17/9376	0.404940830957934	CA8	-1.01232371633123
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1362	66/9376	0.62581764784408	HSD17B2/HSD17B12/COMT/HSD11B2/STS/HSD17B8	-1.25756357864278
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1362	29/9376	0.474758215605853	GNGT1/CALM2	-1.16780859855062
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	20/1362	183/9376	0.752349084839877	FBL/EIF6/NHP2/POP4/SNU13/POP5/RPP30/IMP3/REXO2/RIOK2/RAN/RRP7A/IMP4/NVL/WDR36/RPP38/AK6/NOB1/REXO5/DROSHA	-1.39471790067742
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	35/1362	300/9376	0.803132648066569	PDGFRA/HGF/PRKACB/IGF2/AKT1/ANGPT1/TP53/FGF7/STMN1/MAP2K2/IRAK4/CACNA2D4/EFNA5/CRKL/IKBKG/NLK/MAPK3/MKNK1/FGF10/BDNF/RASA1/CD14/RAC2/ANGPT2/ECSIT/TNFRSF1A/MAP4K2/CSF1R/DUSP9/RRAS/GDNF/DUSP6/HRAS/KITLG/FGFR3	-1.4286853990266
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/1362	76/9376	0.63405209057887	ACTB/PRKACB/ACTG1/SLC4A2/HRH2/CALM2/GNAI1	-1.32048695523799
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	15/1362	144/9376	0.717082721488008	ALDH9A1/AKT1/ACADM/IRAK4/IRF3/PPARA/IKBKG/ADH5/CD14/C2/TNFRSF1A/MLYCD/LEF1/IL17RC/ALDH7A1	-1.41040014152417
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	21/1362	193/9376	0.749035630321152	CXCL14/GNGT1/PRKACB/GNG11/AKT1/PIK3CD/SHC1/JAK3/PIK3R2/CRKL/PARD3/IKBKG/MAPK3/CCL2/RAC2/GNAI1/GNB2/ROCK2/CX3CR1/BAD/HRAS	-1.45227196186568
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/1362	78/9376	0.617794344666591	PIK3CD/SACM1L/CDIPT/FIG4/MTMR2/PIP4K2B/PIP4K2C	-1.39733057576881
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	16/1362	155/9376	0.710605845293923	CD36/ACTB/SEC61A1/ACTG1/DYNC1I2/CORO1A/NCF4/RILP/TUBB2A/ATP6V1E2/CD14/MRC2/COLEC12/CYBB/ATP6V0E2/ATP6V1G1	-1.49766994952945
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/1362	70/9376	0.590056639395846	LAMA2/ACTB/ACTG1/RAC2/SGCE/CAV1	-1.41919108990805
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/1362	71/9376	0.581745982502947	IKBKG/TJP1/GIT1/ATP6V1E2/ATP6V0E2/ATP6V1G1	-1.45834618473039
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/1362	89/9376	0.618785988879539	GNGT1/PRKACB/GNG11/GNAI1/GNB2/GABARAPL2/GABRA3/GABRR2	-1.48962055965486
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	11/1362	115/9376	0.658469003383771	GNGT1/PRKACB/GNG11/AKT1/PIK3CD/PIK3R2/MAPK3/GNAI1/GNB2/CREB3L1/HRAS	-1.51914639178997
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/1362	116/9376	0.652792546458048	GNGT1/HOMER3/PRKACB/GNG11/MAPK3/DLGAP1/GRIA4/GNAI1/GNB2/PLD1/GRIN2C	-1.55117952601871
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	21/1362	200/9376	0.722819383259912	ACTB/ACTG1/ARPC5L/ARPC1A/CASP7/IRAK4/IKBKG/BRK1/TJP1/MYO1B/MYO1C/MAPK3/TUBB2A/PYCARD/RPS3/BAK1/TNFRSF1A/ARPC4/ROCK2/LPAR5/CLDN11	-1.63343055435916
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	17/1362	168/9376	0.696594643731208	PDGFRA/CCND2/CSF2RB/AKT1/IL6ST/PIK3CD/PRLR/CSH1/JAK3/IL12RB2/PIK3R2/PIM1/FHL1/LIFR/PIAS3/HRAS/PIAS4	-1.63585479740985
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/1362	109/9376	0.631559094154576	SPP1/AKT1/PIK3CD/MAP2K2/IRAK4/IRF3/PIK3R2/IKBKG/MAPK3/CD14	-1.59500126482296
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	23/1362	217/9376	0.729639930435724	PRKACB/AKT1/AIP/PIK3CD/FGF7/MAP2K2/ATF6B/PIK3R2/RPS6KB2/PPARA/MAPK3/FGF10/EIF4EBP1/ARNT/MGST2/GNAI1/RXRB/BAD/CREB3L1/ADRB1/HRAS/GSTM4/PAQR8	-1.66110815316759
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/1362	56/9376	0.491713866163205	CASP7/NLRC4/CD14/PYCARD	-1.5726925970054
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	8/1362	94/9376	0.585871840534883	S100A9/SRSF1/MMP9/IKBKG/MAPK3/CCL2/MMP1/IL17RC	-1.66351771436911
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	15/1362	155/9376	0.666192979963052	WNT2/PRKACB/AIP/MAP2K2/ATF6B/CDK4/ASH2L/MAPK3/AGTR1/ARNT/GNAI1/LEF1/DVL1/CREB3L1/WDR5	-1.7275149989089
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/1362	23/9376	0.299304092447168	ARG2	-1.38697155632716
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/1362	23/9376	0.299304092447168	MDH1	-1.38697155632716
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1362	37/9376	0.372107790609993	NIT2/RIMKLB	-1.57755784193624
NA	NA	hsa04081	Hormone signaling	22/1362	219/9376	0.691542788941859	PRKG1/GNGT1/PRKACB/IGF2/GNG11/PIK3CD/STK11/PRLR/CSH1/CGA/PIK3R2/VIPR2/AGTR1/IRS1/SMAD5/GNAI1/GNB2/THRA/MC1R/GNA14/ADRB1/SMAD9	-1.90410064796903
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/1362	26/9376	0.264769004857111	SLC19A3	-1.54758388517656
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/1362	72/9376	0.478055147658672	PIN1/IRF3/MAVS/SIKE1/IKBKG	-1.83275975195489
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/1362	52/9376	0.397153507285666	HSD17B2/PRKACB/CGA	-1.79703609725925
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1362	73/9376	0.471506447005813	HPGDS/ALDH3B1/ADH5/MGST2/GSTM4	-1.86869806680672
Human Diseases	Substance dependence	hsa05034	Alcoholism	18/1362	191/9376	0.648753373157737	GNGT1/HAT1/PPP1CC/PRKACB/GNG11/SHC1/ATF6B/PPP1CA/MAPK3/BDNF/CALM2/HDAC7/GNAI1/GNB2/HDAC10/CREB3L1/HRAS/GRIN2C	-2.0218027758535
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/1362	93/9376	0.518150095526819	RBPJ/JAK3/IL12RB2/IKBKG/NFATC2/MAPK3/MAF	-1.92512351654003
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/1362	93/9376	0.518150095526819	PRKACB/MAP2K2/CGA/MAPK3/CALM2/PLD1/HRAS	-1.92512351654003
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/1362	93/9376	0.518150095526819	PRKG1/PRKACB/SLC4A2/GUCY1A2/CALM2/PRH1/ADRB1	-1.92512351654003
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/1362	75/9376	0.458932941752325	PRKACB/ATF6B/CGA/PDIA4/CREB3L1	-1.9393956897196
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/1362	95/9376	0.507241672463096	ANGPT1/TNFRSF11A/CCL2/ATP6V1E2/MMP1/ATP6V0E2/ATP6V1G1	-1.98997633501231
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/1362	65/9376	0.423630407771377	PRKACB/ATF6B/AGTR1/CREB3L1	-1.92224658679145
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	12/1362	142/9376	0.581745982502947	AKT1/PIK3CD/NCF4/PIK3R2/TNFRSF11A/IKBKG/NFATC2/MAPK3/TNFRSF1A/FHL2/CSF1R/SIRPB1	-2.07032669143478
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	14/1362	160/9376	0.602349486049927	PTPRD/CADM3/NRCAM/ICAM2/NFASC/VCAM1/CDH5/VCAN/ITGA6/NTNG2/ITGA9/NTNG1/CD276/CLDN11	-2.0914131257331
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	25/1362	254/9376	0.677558476996543	RYR2/MCOLN1/PDGFRA/HGF/VDAC2/PRKACB/VDAC1/FGF7/HRH2/CYSLTR1/VDAC3/ORAI3/NFATC2/FGF10/CALM2/AGTR1/SPHK2/PTGFR/EDNRB/GDNF/GNA14/ADRB1/HRH1/FGFR3/GRIN2C	-2.14769354134648
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	18/1362	195/9376	0.635445611657065	ACTB/HAT1/VDAC2/ACTG1/AKT1/PIK3CD/VDAC1/MAP2K2/NCF4/VDAC3/PIK3R2/MAPK3/RAC2/HDAC7/GSDMD/HDAC10/CYBB/FPR2	-2.12072406885017
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/1362	115/9376	0.538747366404903	PRKACB/ATF6B/MAPK3/NACA/GNAI1/RXRB/LRP6/CREB3L1/PLD1	-2.05167402365234
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/1362	98/9376	0.491713866163205	PRKACB/ATF6B/CALM2/AGTR1/PRKD1/KCNJ5/CREB3L1	-2.08518042330705
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/1362	99/9376	0.486747059434284	PPP1CC/PRKACB/PIK3CD/PIK3R2/PPP1CA/CALM2/HRH1	-2.11638555260166
Human Diseases	Immune disease	hsa05310	Asthma	1/1362	32/9376	0.215124816446402	PRG2	-1.83340619655761
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1362	70/9376	0.393371092930564	HPGDS/CBR1/MGST2/GSTM4	-2.10010070299668
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/1362	133/9376	0.51759354332969	ICAM2/SH3BP2/PIK3CD/SHC1/MAP2K2/PIK3R2/NFATC2/MAPK3/RAC2/HRAS	-2.30984043056411
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/1362	115/9376	0.47888654791547	GNGT1/PRKACB/GNG11/MAPK3/GNAI1/GNB2/KCNJ5/HRAS	-2.31793783958353
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/1362	36/9376	0.191222059063469	C1GALT1C1	-2.00427187728283
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/1362	78/9376	0.353025339809481	NCF4/IRAK4/MAPK3/CYBB	-2.36531684399916
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/1362	100/9376	0.413039647577092	CXCL14/IL6ST/CCL2/TNFRSF1A/CSF1R/CX3CR1	-2.43264042680115
NA	NA	hsa04382	Cornified envelope formation	18/1362	217/9376	0.571022554254045	SLC27A4/S100A9/S100A6/PPP2CB/FURIN/ELOVL1/S100A11/COL4A1/TJP1/KRT18/CAPN1/PPP2R5D/KRT10/KRT1/ITGA6/COL4A2/CLDN11/PPP2R3B	-2.63566263243694
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/1362	68/9376	0.30370562321845	DHRS4L2/ADH5/PNPLA4	-2.37557463697371
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/1362	82/9376	0.335804591526091	LGMN/HSPA2/RFXANK/NFYB	-2.49029607506259
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/1362	86/9376	0.320185773315576	RYR2/PRKACB/ATF6B/CREB3L1	-2.61084530673007
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/1362	109/9376	0.378935456492745	IL6ST/JAK3/IKBKG/NFATC2/MAPK3/RXRB	-2.68862310540068
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/1362	61/9376	0.225704725451963	HMOX2/CYBRD1	-2.50109172678641
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	13/1362	181/9376	0.494430517357477	AKT1/CORO1A/IRAK4/RFXANK/MAPK3/CD14/CALM2/CARD9/SPHK2/TNFRSF1A/MRC2/NFYB/BAD	-2.83135153999216
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/1362	99/9376	0.347676471024489	C1S/KRT18/C2/KRT10/FPR2	-2.68983961557866
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/1362	100/9376	0.344199706314244	CD36/CD14/CSF1R/ITGA6/KITLG	-2.71794559844239
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/1362	66/9376	0.208605882614693	IL12RB2/MAF	-2.65974173458936
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	27/1362	323/9376	0.575442233466537	TIMP3/PDGFRA/CCND2/ZFPM2/MDM4/UBE2I/DNMT3A/TP53/PIK3CD/STMN1/SHC1/MAP2K2/CCNG1/PIK3R2/ATM/PIM1/EFNA5/CRKL/MMP9/FSCN1/MAPK3/BCL2L2/IRS1/BAK1/PAK4/HRAS/FGFR3	-3.20104156821206
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/1362	54/9376	0.127481372708979	CGA	-2.65073651663722
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/1362	86/9376	0.240139329986682	SCN9A/PRKACB/GABRA3	-2.9182658823555
NA	NA	hsa04082	Neuroactive ligand signaling	13/1362	199/9376	0.449708159003535	GNGT1/PRKACB/GNG11/HRH2/TAC3/GRIA4/GNAI1/GNB2/GABRA3/ADRB1/HRH1/GABRR2/GRIN2C	-3.23458649536014
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/1362	102/9376	0.269960553971956	RYR2/SLC4A2/PLA2G2A/PLA2G12A	-3.05606361250438
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/1362	90/9376	0.229466470876162	PRKACB/SLC4A2/SLC27A5	-3.02794497982229
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	21/1362	298/9376	0.485113680040209	CXCL14/BMP5/BMP4/TNFSF12/CSF2RB/IL6ST/PRLR/IL16/CSH1/EDA/ACVR2A/IL1RN/IL12RB2/TNFRSF11A/CCL2/TNFRSF1A/TNFRSF25/CSF1R/CX3CR1/IL17RC/LIFR	-3.72369343386826
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/1362	143/9376	0.240699095324646	C7/C1S/SNRPD1/SNRPD3/C2	-3.77189887910678
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	25/1362	370/9376	0.465134738262492	SPX/PGRMC1/PRLR/S1PR1/CSH1/HRH2/CGA/CYSLTR1/VIPR2/LYPD6/TAC3/GRIA4/AGTR1/PTGFR/GABRA3/THRA/EDNRB/MC1R/LTB4R/S1PR2/ADRB1/FPR2/HRH1/GABRR2/GRIN2C	-4.32741758991537
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/1362	449/9376	0.045995506411703	PRKG1/PRKACB/CALM2	-8.54024532674295