ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 109/2815 175/18639 0.622857142857143 4.12413296117737 2.53286551658697e-46 3.23700213019815e-43 GO:0009055 electron transfer activity 57/2815 116/18639 0.491379310344828 3.25357689716421 5.45743350971688e-18 3.48730001270908e-15 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 41/2815 68/18639 0.602941176470588 3.99226308640685 1.66898756755782e-17 7.10988703779632e-15 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 36/2815 58/18639 0.620689655172414 4.10978134378637 4.10864155718154e-16 1.3127109775195e-13 GO:0008137 NADH dehydrogenase (ubiquinone) activity 29/2815 41/18639 0.707317073170732 4.6833687129056 1.67038092932839e-15 4.26949365536336e-13 GO:0003954 NADH dehydrogenase activity 30/2815 44/18639 0.681818181818182 4.51453253673502 2.65833503692113e-15 5.662253628642e-13 GO:0016651 oxidoreductase activity, acting on NAD(P)H 40/2815 88/18639 0.454545454545455 3.00968835782335 1.11738303621584e-11 2.04002217183407e-09 GO:0022853 active monoatomic ion transmembrane transporter activity 45/2815 118/18639 0.38135593220339 2.52507752054671 7.66687910679335e-10 1.22478393731024e-07 GO:0015078 proton transmembrane transporter activity 60/2815 185/18639 0.324324324324324 2.14745331477125 2.37281026831367e-09 3.36939058100541e-07 GO:0019843 rRNA binding 30/2815 65/18639 0.461538461538462 3.05599125563602 2.63722308325877e-09 3.37037110040471e-07 GO:0015399 primary active transmembrane transporter activity 51/2815 166/18639 0.307228915662651 2.03425923944446 2.53258245619752e-07 2.94240034456403e-05 GO:0043021 ribonucleoprotein complex binding 53/2815 177/18639 0.299435028248588 1.98265346057742 3.70295126195979e-07 3.94364309398718e-05 GO:0140104 molecular carrier activity 64/2815 249/18639 0.257028112449799 1.70186393888164 8.54387167973782e-06 0.000839928308208072 GO:0051537 2 iron, 2 sulfur cluster binding 14/2815 28/18639 0.5 3.31065719360568 1.52514906131143e-05 0.00139224321454 GO:0016853 isomerase activity 48/2815 180/18639 0.266666666666667 1.7656838365897 4.01648575640854e-05 0.00301431012327413 GO:0032977 membrane insertase activity 10/2815 17/18639 0.588235294117647 3.89489081600669 4.24550721587905e-05 0.00301431012327413 GO:0048038 quinone binding 10/2815 17/18639 0.588235294117647 3.89489081600669 4.24550721587905e-05 0.00301431012327413 GO:0070402 NADPH binding 10/2815 17/18639 0.588235294117647 3.89489081600669 4.24550721587905e-05 0.00301431012327413 GO:0051287 NAD binding 20/2815 54/18639 0.37037037037037 2.45233866193014 6.32569254432349e-05 0.0042548605640239 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 10/2815 18/18639 0.555555555555556 3.6785079928952 8.25730750124818e-05 0.00527641949329759 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 44/2815 167/18639 0.263473053892216 1.74453792237904 0.000111505083384253 0.0067858807888131 GO:0140297 DNA-binding transcription factor binding 103/2815 488/18639 0.211065573770492 1.39753152025158 0.00020144028654779 0.0117018493730944 GO:0051536 iron-sulfur cluster binding 24/2815 76/18639 0.315789473684211 2.09094138543517 0.000226549100450029 0.0122692234298715 GO:0016859 cis-trans isomerase activity 16/2815 42/18639 0.380952380952381 2.52240548084243 0.000230407951734677 0.0122692234298715 GO:0051540 metal cluster binding 24/2815 77/18639 0.311688311688312 2.06378630250744 0.000282578845551898 0.014445430584613 GO:0016741 transferase activity, transferring one-carbon groups 52/2815 215/18639 0.241860465116279 1.60143417737205 0.000297598772089279 0.01462812425885 GO:0048407 platelet-derived growth factor binding 7/2815 11/18639 0.636363636363636 4.21356370095269 0.000334535807265638 0.0158346948772402 GO:0043022 ribosome binding 31/2815 112/18639 0.276785714285714 1.83268523217458 0.000436205140737763 0.0199096489236736 GO:0016860 intramolecular oxidoreductase activity 18/2815 53/18639 0.339622641509434 2.24874828244914 0.000502839576310002 0.0221596199491098 GO:0016209 antioxidant activity 25/2815 86/18639 0.290697674418605 1.92480069395679 0.000689765678440255 0.0278783978953045 GO:0003995 acyl-CoA dehydrogenase activity 7/2815 12/18639 0.583333333333333 3.86243339253996 0.000698050651525622 0.0278783978953045 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 7/2815 12/18639 0.583333333333333 3.86243339253996 0.000698050651525622 0.0278783978953045 GO:0050750 low-density lipoprotein particle receptor binding 11/2815 26/18639 0.423076923076923 2.80132531766635 0.000779297569896099 0.0301800695250671 GO:0008168 methyltransferase activity 48/2815 204/18639 0.235294117647059 1.55795632640267 0.000947206658871167 0.0356038267658045 GO:0008170 N-methyltransferase activity 27/2815 98/18639 0.275510204081633 1.82423967810925 0.00106875459148448 0.0390248105119192 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 14/2815 39/18639 0.358974358974359 2.3768820877169 0.00111710633101383 0.0396572747509911 GO:0016504 peptidase activator activity 18/2815 57/18639 0.315789473684211 2.09094138543517 0.00132494976028379 0.0453483254643309 GO:0031720 haptoglobin binding 6/2815 10/18639 0.6 3.97278863232682 0.00143029206456765 0.0453483254643309 GO:0033204 ribonuclease P RNA binding 6/2815 10/18639 0.6 3.97278863232682 0.00143029206456765 0.0453483254643309 GO:0047429 nucleoside triphosphate diphosphatase activity 6/2815 10/18639 0.6 3.97278863232682 0.00143029206456765 0.0453483254643309 GO:0008276 protein methyltransferase activity 26/2815 95/18639 0.273684210526316 1.81214920071048 0.00145483673242376 0.0453483254643309 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 13/2815 36/18639 0.361111111111111 2.39103019538188 0.00156485969427322 0.0454520611200267 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 13/2815 36/18639 0.361111111111111 2.39103019538188 0.00156485969427322 0.0454520611200267 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 13/2815 36/18639 0.361111111111111 2.39103019538188 0.00156485969427322 0.0454520611200267 GO:0004549 tRNA-specific ribonuclease activity 8/2815 17/18639 0.470588235294118 3.11591265280535 0.00180883935269574 0.0513710376165592 GO:0030145 manganese ion binding 20/2815 68/18639 0.294117647058824 1.94744540800334 0.00194791737493593 0.054118226199307 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 31/2815 122/18639 0.254098360655738 1.68246513117666 0.00201821099729501 0.0545654757663544 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 18/2815 59/18639 0.305084745762712 2.02006201643737 0.00204940754052035 0.0545654757663544 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 32/2815 128/18639 0.25 1.65532859680284 0.00228466386131095 0.0585137903913089 GO:0016530 metallochaperone activity 7/2815 14/18639 0.5 3.31065719360568 0.0022892719245426 0.0585137903913089 GO:0140101 catalytic activity, acting on a tRNA 34/2815 139/18639 0.244604316546763 1.61960208032508 0.00250685992985457 0.0628189605951792 GO:0070990 snRNP binding 6/2815 11/18639 0.545454545454545 3.61162602938802 0.00274519957333006 0.067468558744535 GO:0008175 tRNA methyltransferase activity 12/2815 34/18639 0.352941176470588 2.33693448960401 0.00293231525946545 0.0707075264452235 GO:0061133 endopeptidase activator activity 9/2815 22/18639 0.409090909090909 2.70871952204101 0.00309025000393781 0.0727130817243934 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 72/2815 349/18639 0.206303724928367 1.36600182200349 0.00312927972992304 0.0727130817243934 GO:0005201 extracellular matrix structural constituent 39/2815 168/18639 0.232142857142857 1.53709083988835 0.00346254284472557 0.0787024528902135 GO:0004601 peroxidase activity 17/2815 57/18639 0.298245614035088 1.97477797513321 0.00351020329792032 0.0787024528902135 GO:0005523 tropomyosin binding 7/2815 15/18639 0.466666666666667 3.08994671403197 0.00373648148892823 0.0795870557141712 GO:0016846 carbon-sulfur lyase activity 7/2815 15/18639 0.466666666666667 3.08994671403197 0.00373648148892823 0.0795870557141712 GO:0055105 ubiquitin-protein transferase inhibitor activity 7/2815 15/18639 0.466666666666667 3.08994671403197 0.00373648148892823 0.0795870557141712 GO:0034212 protein N-acetyltransferase activity 16/2815 53/18639 0.30188679245283 1.99888736217702 0.00399057055206175 0.0836057240251626 GO:0070325 lipoprotein particle receptor binding 11/2815 31/18639 0.354838709677419 2.34949865352661 0.00413646388733622 0.0852645298067046 GO:0015252 proton channel activity 10/2815 27/18639 0.37037037037037 2.45233866193014 0.00433885477993046 0.088016768392875 GO:0004526 ribonuclease P activity 6/2815 12/18639 0.5 3.31065719360568 0.0047923484951345 0.0927972935876044 GO:0016423 tRNA (guanine) methyltransferase activity 6/2815 12/18639 0.5 3.31065719360568 0.0047923484951345 0.0927972935876044 GO:0036009 protein-glutamine N-methyltransferase activity 6/2815 12/18639 0.5 3.31065719360568 0.0047923484951345 0.0927972935876044 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 16/2815 54/18639 0.296296296296296 1.96187092954411 0.00489063583040108 0.0932870536007847 GO:0016829 lyase activity 44/2815 200/18639 0.22 1.4566891651865 0.00573632478185219 0.107809162811869 GO:0048027 mRNA 5'-UTR binding 9/2815 24/18639 0.375 2.48299289520426 0.00611602183513491 0.112262937340897 GO:0140939 histone H4 methyltransferase activity 8/2815 20/18639 0.4 2.64852575488455 0.00614898717829638 0.112262937340897 GO:0000287 magnesium ion binding 49/2815 230/18639 0.21304347826087 1.41062784771025 0.00708258626035959 0.126435805023392 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 31/2815 132/18639 0.234848484848485 1.55500565154206 0.00712314394497985 0.126435805023392 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 17/2815 61/18639 0.278688524590164 1.84528433741956 0.0074535423702103 0.13048804313875 GO:0140597 protein carrier chaperone 41/2815 188/18639 0.218085106382979 1.44401005253014 0.00868283748136173 0.146799237399911 GO:0140098 catalytic activity, acting on RNA 76/2815 387/18639 0.196382428940568 1.3003098021397 0.00873945612186145 0.146799237399911 GO:0008173 RNA methyltransferase activity 18/2815 67/18639 0.26865671641791 1.77886058163887 0.00900177524427882 0.146799237399911 GO:0042054 histone methyltransferase activity 18/2815 67/18639 0.26865671641791 1.77886058163887 0.00900177524427882 0.146799237399911 GO:0015035 protein-disulfide reductase activity 11/2815 34/18639 0.323529411764706 2.14218994880368 0.00907444425242014 0.146799237399911 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 11/2815 34/18639 0.323529411764706 2.14218994880368 0.00907444425242014 0.146799237399911 GO:0140030 modification-dependent protein binding 38/2815 173/18639 0.219653179190751 1.45439275557244 0.00996623295506237 0.152570955695262 GO:0032356 oxidized DNA binding 5/2815 10/18639 0.5 3.31065719360568 0.0101475205274627 0.152570955695262 GO:0043295 glutathione binding 5/2815 10/18639 0.5 3.31065719360568 0.0101475205274627 0.152570955695262 GO:0097177 mitochondrial ribosome binding 5/2815 10/18639 0.5 3.31065719360568 0.0101475205274627 0.152570955695262 GO:0140940 histone H2A methyltransferase activity 5/2815 10/18639 0.5 3.31065719360568 0.0101475205274627 0.152570955695262 GO:1990259 histone H2AQ104 methyltransferase activity 5/2815 10/18639 0.5 3.31065719360568 0.0101475205274627 0.152570955695262 GO:0030020 extracellular matrix structural constituent conferring tensile strength 13/2815 44/18639 0.295454545454545 1.95629743258518 0.0109294048261344 0.162416039160463 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 8/2815 22/18639 0.363636363636364 2.40775068625868 0.0118070670597901 0.171119644762445 GO:0005344 oxygen carrier activity 6/2815 14/18639 0.428571428571429 2.83770616594773 0.011884956558463 0.171119644762445 GO:0017069 snRNA binding 15/2815 54/18639 0.277777777777778 1.8392539964476 0.0119167827729715 0.171119644762445 GO:0031593 polyubiquitin modification-dependent protein binding 16/2815 59/18639 0.271186440677966 1.79561068127766 0.01216711725992 0.1720957853858 GO:0003684 damaged DNA binding 19/2815 74/18639 0.256756756756757 1.70006720752724 0.0122540817449983 0.1720957853858 GO:0030331 nuclear estrogen receptor binding 12/2815 40/18639 0.3 1.98639431616341 0.0125242486513411 0.17397814974363 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 16/2815 60/18639 0.266666666666667 1.7656838365897 0.0143243127441036 0.196843781580262 GO:0140102 catalytic activity, acting on a rRNA 8/2815 23/18639 0.347826086956522 2.30306587381265 0.0157550823906677 0.214202077609291 GO:0043425 bHLH transcription factor binding 10/2815 32/18639 0.3125 2.06916074600355 0.0162741374709521 0.214969103610809 GO:1900750 oligopeptide binding 5/2815 11/18639 0.454545454545455 3.00968835782335 0.0163161213225732 0.214969103610809 GO:1990948 ubiquitin ligase inhibitor activity 5/2815 11/18639 0.454545454545455 3.00968835782335 0.0163161213225732 0.214969103610809 GO:0004129 cytochrome-c oxidase activity 6/2815 15/18639 0.4 2.64852575488455 0.0173172732714861 0.225831380009789 GO:0016410 N-acyltransferase activity 22/2815 94/18639 0.234042553191489 1.54966932466649 0.0217963094390025 0.28094288618744 GO:0051082 unfolded protein binding 27/2815 121/18639 0.223140495867769 1.47748337565874 0.0219830114387668 0.28094288618744 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 12/2815 43/18639 0.27906976744186 1.84780866619852 0.022339671621185 0.282674260711629 GO:0005507 copper ion binding 16/2815 63/18639 0.253968253968254 1.68160365389495 0.022601458366677 0.283182978358953 GO:0004527 exonuclease activity 20/2815 84/18639 0.238095238095238 1.57650342552652 0.0233660262973672 0.28992020978675 GO:0016675 oxidoreductase activity, acting on a heme group of donors 6/2815 16/18639 0.375 2.48299289520426 0.0242367391877604 0.297832237326517 GO:0097371 MDM2/MDM4 family protein binding 5/2815 12/18639 0.416666666666667 2.7588809946714 0.0245473876278865 0.29877677512799 GO:0008080 N-acetyltransferase activity 17/2815 69/18639 0.246376811594203 1.63133832728396 0.0254756000375415 0.302496903692236 GO:0016279 protein-lysine N-methyltransferase activity 17/2815 69/18639 0.246376811594203 1.63133832728396 0.0254756000375415 0.302496903692236 GO:0016874 ligase activity 35/2815 167/18639 0.209580838323353 1.38770062007424 0.0255631186218791 0.302496903692236 GO:0000030 mannosyltransferase activity 8/2815 25/18639 0.32 2.11882060390764 0.0263526576705429 0.30540997628569 GO:0016790 thiolester hydrolase activity 12/2815 44/18639 0.272727272727273 1.80581301469401 0.0266185216693289 0.30540997628569 GO:0019205 nucleobase-containing compound kinase activity 12/2815 44/18639 0.272727272727273 1.80581301469401 0.0266185216693289 0.30540997628569 GO:0050661 NADP binding 14/2815 54/18639 0.259259259259259 1.7166370633511 0.026765193539904 0.30540997628569 GO:0016407 acetyltransferase activity 22/2815 96/18639 0.229166666666667 1.51738454706927 0.0273254701551919 0.309043812905621 GO:0016278 lysine N-methyltransferase activity 17/2815 70/18639 0.242857142857143 1.60803349403705 0.0290609508710078 0.325788554501298 GO:0140312 cargo adaptor activity 7/2815 21/18639 0.333333333333333 2.20710479573712 0.0296538525626426 0.329544552826585 GO:0016791 phosphatase activity 53/2815 273/18639 0.194139194139194 1.28545663927547 0.0304780080687049 0.33578357165349 GO:0015036 disulfide oxidoreductase activity 11/2815 40/18639 0.275 1.82086145648313 0.0311460739902296 0.337327818300961 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 11/2815 40/18639 0.275 1.82086145648313 0.0311460739902296 0.337327818300961 GO:0051539 4 iron, 4 sulfur cluster binding 12/2815 45/18639 0.266666666666667 1.7656838365897 0.0314636664186551 0.337903913302867 GO:0003712 transcription coregulator activity 90/2815 495/18639 0.181818181818182 1.20387534312934 0.0326259030021395 0.343418622013415 GO:0004550 nucleoside diphosphate kinase activity 6/2815 17/18639 0.352941176470588 2.33693448960401 0.0327833113346139 0.343418622013415 GO:0004659 prenyltransferase activity 6/2815 17/18639 0.352941176470588 2.33693448960401 0.0327833113346139 0.343418622013415 GO:0008198 ferrous iron binding 8/2815 26/18639 0.307692307692308 2.03732750375734 0.0331675369540821 0.344618798596073 GO:0009982 pseudouridine synthase activity 5/2815 13/18639 0.384615384615385 2.54665937969668 0.0350316797160763 0.355321322834488 GO:0019104 DNA N-glycosylase activity 5/2815 13/18639 0.384615384615385 2.54665937969668 0.0350316797160763 0.355321322834488 GO:0070700 BMP receptor binding 5/2815 13/18639 0.384615384615385 2.54665937969668 0.0350316797160763 0.355321322834488 GO:0070273 phosphatidylinositol-4-phosphate binding 9/2815 31/18639 0.290322580645161 1.92231708015814 0.0353114421642715 0.355338764456212 GO:0055106 ubiquitin-protein transferase regulator activity 10/2815 36/18639 0.277777777777778 1.8392539964476 0.036477737339601 0.361743632317455 GO:0016830 carbon-carbon lyase activity 13/2815 51/18639 0.254901960784314 1.68778602026956 0.0365140286142032 0.361743632317455 GO:0008649 rRNA methyltransferase activity 7/2815 22/18639 0.318181818181818 2.10678185047634 0.0379823524639736 0.370545392740139 GO:0140517 protein-RNA adaptor activity 7/2815 22/18639 0.318181818181818 2.10678185047634 0.0379823524639736 0.370545392740139 GO:0008320 protein transmembrane transporter activity 8/2815 27/18639 0.296296296296296 1.96187092954411 0.0410867771309989 0.397794705859217 GO:0004521 RNA endonuclease activity 17/2815 73/18639 0.232876712328767 1.54194992578895 0.0420619316816707 0.401726714115451 GO:0140142 nucleocytoplasmic carrier activity 9/2815 32/18639 0.28125 1.8622446714032 0.0427608222616573 0.401726714115451 GO:0061733 protein-lysine-acetyltransferase activity 12/2815 47/18639 0.25531914893617 1.69054835418163 0.0429882050390532 0.401726714115451 GO:0098641 cadherin binding involved in cell-cell adhesion 6/2815 18/18639 0.333333333333333 2.20710479573712 0.0430646008089333 0.401726714115451 GO:1901611 phosphatidylglycerol binding 6/2815 18/18639 0.333333333333333 2.20710479573712 0.0430646008089333 0.401726714115451 GO:0004402 histone acetyltransferase activity 11/2815 42/18639 0.261904761904762 1.73415376807917 0.0434575419049086 0.402454627206327 GO:0004518 nuclease activity 41/2815 209/18639 0.196172248803828 1.29891813337639 0.0448094772423222 0.411989294357466 GO:0008408 3'-5' exonuclease activity 14/2815 58/18639 0.241379310344828 1.59824830036136 0.0469843152734897 0.422101104269317 GO:0140103 catalytic activity, acting on a glycoprotein 7/2815 23/18639 0.304347826086957 2.01518263958607 0.0477067831210449 0.422101104269317 GO:0008474 palmitoyl-(protein) hydrolase activity 5/2815 14/18639 0.357142857142857 2.36475513828977 0.0478909703591949 0.422101104269317 GO:0071933 Arp2/3 complex binding 5/2815 14/18639 0.357142857142857 2.36475513828977 0.0478909703591949 0.422101104269317 GO:0098599 palmitoyl hydrolase activity 5/2815 14/18639 0.357142857142857 2.36475513828977 0.0478909703591949 0.422101104269317 GO:1901612 cardiolipin binding 5/2815 14/18639 0.357142857142857 2.36475513828977 0.0478909703591949 0.422101104269317 GO:0016866 intramolecular transferase activity 8/2815 28/18639 0.285714285714286 1.89180411063182 0.0501653741568334 0.427632771599058 GO:0046966 nuclear thyroid hormone receptor binding 8/2815 28/18639 0.285714285714286 1.89180411063182 0.0501653741568334 0.427632771599058 GO:0097718 disordered domain specific binding 8/2815 28/18639 0.285714285714286 1.89180411063182 0.0501653741568334 0.427632771599058 GO:0000049 tRNA binding 18/2815 80/18639 0.225 1.48979573712256 0.0503579299213127 0.427632771599058 GO:0004090 carbonyl reductase (NADPH) activity 4/2815 10/18639 0.4 2.64852575488455 0.0510279418053402 0.427632771599058 GO:0008641 ubiquitin-like modifier activating enzyme activity 4/2815 10/18639 0.4 2.64852575488455 0.0510279418053402 0.427632771599058 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 4/2815 10/18639 0.4 2.64852575488455 0.0510279418053402 0.427632771599058 GO:0140416 transcription regulator inhibitor activity 9/2815 33/18639 0.272727272727273 1.80581301469401 0.0511954726562253 0.427632771599058 GO:0003756 protein disulfide isomerase activity 6/2815 19/18639 0.315789473684211 2.09094138543517 0.0551527704314145 0.438719064324982 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 6/2815 19/18639 0.315789473684211 2.09094138543517 0.0551527704314145 0.438719064324982 GO:0033192 calmodulin-dependent protein phosphatase activity 18/2815 81/18639 0.222222222222222 1.47140319715808 0.0559555614123412 0.438719064324982 GO:0140791 histone H2AXS140 phosphatase activity 18/2815 81/18639 0.222222222222222 1.47140319715808 0.0559555614123412 0.438719064324982 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 18/2815 81/18639 0.222222222222222 1.47140319715808 0.0559555614123412 0.438719064324982 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 18/2815 81/18639 0.222222222222222 1.47140319715808 0.0559555614123412 0.438719064324982 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 18/2815 81/18639 0.222222222222222 1.47140319715808 0.0559555614123412 0.438719064324982 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 18/2815 81/18639 0.222222222222222 1.47140319715808 0.0559555614123412 0.438719064324982 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 18/2815 81/18639 0.222222222222222 1.47140319715808 0.0559555614123412 0.438719064324982 GO:1990439 MAP kinase serine/threonine phosphatase activity 18/2815 81/18639 0.222222222222222 1.47140319715808 0.0559555614123412 0.438719064324982 GO:0016776 phosphotransferase activity, phosphate group as acceptor 10/2815 39/18639 0.256410256410256 1.69777291979779 0.0599825182282437 0.46742474570546 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 18/2815 82/18639 0.219512195121951 1.45345925572932 0.0619723111499357 0.474948544459393 GO:0033549 MAP kinase phosphatase activity 18/2815 82/18639 0.219512195121951 1.45345925572932 0.0619723111499357 0.474948544459393 GO:0004519 endonuclease activity 26/2815 127/18639 0.204724409448819 1.35554467769682 0.0622121791775272 0.474948544459393 GO:0140313 molecular sequestering activity 13/2815 55/18639 0.236363636363636 1.56503794606814 0.0628336521404927 0.474948544459393 GO:0045296 cadherin binding 61/2815 334/18639 0.182634730538922 1.20928196892184 0.0631238434527736 0.474948544459393 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 5/2815 15/18639 0.333333333333333 2.20710479573712 0.0631778189030492 0.474948544459393 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 18/2815 83/18639 0.216867469879518 1.43594769843138 0.0684186167289115 0.508025743819121 GO:0000339 RNA cap binding 6/2815 20/18639 0.3 1.98639431616341 0.0690832405408205 0.508025743819121 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 6/2815 20/18639 0.3 1.98639431616341 0.0690832405408205 0.508025743819121 GO:0004721 phosphoprotein phosphatase activity 34/2815 175/18639 0.194285714285714 1.28642679522964 0.0702703323883251 0.508025743819121 GO:0008046 axon guidance receptor activity 4/2815 11/18639 0.363636363636364 2.40775068625868 0.0708632677954926 0.508025743819121 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 4/2815 11/18639 0.363636363636364 2.40775068625868 0.0708632677954926 0.508025743819121 GO:0097493 structural molecule activity conferring elasticity 4/2815 11/18639 0.363636363636364 2.40775068625868 0.0708632677954926 0.508025743819121 GO:0017025 TBP-class protein binding 7/2815 25/18639 0.28 1.85396802841918 0.0715279293884196 0.508025743819121 GO:0043995 histone H4K5 acetyltransferase activity 8/2815 30/18639 0.266666666666667 1.7656838365897 0.0719504378961352 0.508025743819121 GO:0043996 histone H4K8 acetyltransferase activity 8/2815 30/18639 0.266666666666667 1.7656838365897 0.0719504378961352 0.508025743819121 GO:0043997 histone H4K12 acetyltransferase activity 8/2815 30/18639 0.266666666666667 1.7656838365897 0.0719504378961352 0.508025743819121 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 43/2815 229/18639 0.187772925764192 1.24330357489122 0.0737524480531742 0.517612332927292 GO:0033218 amide binding 46/2815 247/18639 0.186234817813765 1.23311927858997 0.0741181979074292 0.517612332927292 GO:0016887 ATP hydrolysis activity 74/2815 417/18639 0.177458033573141 1.17500543082408 0.0749634373197974 0.520203925591236 GO:0017018 myosin phosphatase activity 18/2815 84/18639 0.214285714285714 1.41885308297386 0.0753033851599207 0.520203925591236 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 11/2815 46/18639 0.239130434782609 1.5833577882462 0.0772157873335042 0.530547183936658 GO:0016877 ligase activity, forming carbon-sulfur bonds 10/2815 41/18639 0.24390243902439 1.61495472858814 0.0801269194647974 0.535556890023439 GO:0061650 ubiquitin-like protein conjugating enzyme activity 10/2815 41/18639 0.24390243902439 1.61495472858814 0.0801269194647974 0.535556890023439 GO:0140318 protein transporter activity 10/2815 41/18639 0.24390243902439 1.61495472858814 0.0801269194647974 0.535556890023439 GO:0008142 oxysterol binding 5/2815 16/18639 0.3125 2.06916074600355 0.0808783096827259 0.535556890023439 GO:0008296 3'-5'-DNA exonuclease activity 5/2815 16/18639 0.3125 2.06916074600355 0.0808783096827259 0.535556890023439 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 5/2815 16/18639 0.3125 2.06916074600355 0.0808783096827259 0.535556890023439 GO:0017070 U6 snRNA binding 5/2815 16/18639 0.3125 2.06916074600355 0.0808783096827259 0.535556890023439 GO:0031491 nucleosome binding 16/2815 74/18639 0.216216216216216 1.43163554318084 0.0841451359569709 0.554316926561901 GO:0072542 protein phosphatase activator activity 6/2815 21/18639 0.285714285714286 1.89180411063182 0.0848549957320916 0.555707521273627 GO:0016922 nuclear receptor binding 27/2815 137/18639 0.197080291970803 1.30493057266209 0.0853799153820943 0.555707521273627 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 7/2815 26/18639 0.269230769230769 1.78266156578768 0.0856607055484386 0.555707521273627 GO:0043495 protein-membrane adaptor activity 11/2815 47/18639 0.234042553191489 1.54966932466649 0.0876742152568087 0.565897207566674 GO:0002039 p53 binding 15/2815 69/18639 0.217391304347826 1.43941617113291 0.0889606049503593 0.571314839831956 GO:0004722 protein serine/threonine phosphatase activity 21/2815 103/18639 0.203883495145631 1.34997671972271 0.0897752611899788 0.573663919003964 GO:0140097 catalytic activity, acting on DNA 60/2815 336/18639 0.178571428571429 1.18237756914489 0.091168792587598 0.577891201281736 GO:0000995 RNA polymerase III general transcription initiation factor activity 4/2815 12/18639 0.333333333333333 2.20710479573712 0.0940212078792957 0.577891201281736 GO:0005049 nuclear export signal receptor activity 4/2815 12/18639 0.333333333333333 2.20710479573712 0.0940212078792957 0.577891201281736 GO:0016208 AMP binding 4/2815 12/18639 0.333333333333333 2.20710479573712 0.0940212078792957 0.577891201281736 GO:0016273 arginine N-methyltransferase activity 4/2815 12/18639 0.333333333333333 2.20710479573712 0.0940212078792957 0.577891201281736 GO:0016274 protein-arginine N-methyltransferase activity 4/2815 12/18639 0.333333333333333 2.20710479573712 0.0940212078792957 0.577891201281736 GO:1990459 transferrin receptor binding 4/2815 12/18639 0.333333333333333 2.20710479573712 0.0940212078792957 0.577891201281736 GO:0004536 DNA nuclease activity 14/2815 64/18639 0.21875 1.44841252220249 0.0940542800208146 0.577891201281736 GO:0003697 single-stranded DNA binding 24/2815 121/18639 0.198347107438017 1.3133185561411 0.0946673148768706 0.578874777093974 GO:0019787 ubiquitin-like protein transferase activity 83/2815 479/18639 0.173277661795407 1.14732587502827 0.0961491427995936 0.58513621189467 GO:0022884 macromolecule transmembrane transporter activity 8/2815 32/18639 0.25 1.65532859680284 0.0986723077948689 0.595038176508448 GO:0032266 phosphatidylinositol-3-phosphate binding 11/2815 48/18639 0.229166666666667 1.51738454706927 0.0989556295566196 0.595038176508448 GO:0004842 ubiquitin-protein transferase activity 78/2815 449/18639 0.173719376391982 1.15025060624162 0.0996257365438749 0.595038176508448 GO:0004029 aldehyde dehydrogenase (NAD+) activity 5/2815 17/18639 0.294117647058824 1.94744540800334 0.100917892327772 0.595038176508448 GO:0042578 phosphoric ester hydrolase activity 64/2815 363/18639 0.176308539944904 1.16739427212542 0.101171658774708 0.595038176508448 GO:0004364 glutathione transferase activity 7/2815 27/18639 0.259259259259259 1.7166370633511 0.101261580494543 0.595038176508448 GO:0030021 extracellular matrix structural constituent conferring compression resistance 6/2815 22/18639 0.272727272727273 1.80581301469401 0.102432236957636 0.595038176508448 GO:0034062 5'-3' RNA polymerase activity 6/2815 22/18639 0.272727272727273 1.80581301469401 0.102432236957636 0.595038176508448 GO:0046972 histone H4K16 acetyltransferase activity 6/2815 22/18639 0.272727272727273 1.80581301469401 0.102432236957636 0.595038176508448 GO:0097747 RNA polymerase activity 6/2815 22/18639 0.272727272727273 1.80581301469401 0.102432236957636 0.595038176508448 GO:0042162 telomeric DNA binding 9/2815 38/18639 0.236842105263158 1.56820603907638 0.108994512930719 0.63029406120117 GO:0016757 glycosyltransferase activity 48/2815 267/18639 0.179775280898876 1.1903486538807 0.110010479456029 0.633303570922548 GO:0016755 aminoacyltransferase activity 85/2815 496/18639 0.171370967741935 1.13470105426001 0.112594502424368 0.64527252958898 GO:0140311 protein sequestering activity 8/2815 33/18639 0.242424242424242 1.60516712417245 0.113864895039235 0.649639892232779 GO:0036408 histone H3K14 acetyltransferase activity 7/2815 28/18639 0.25 1.65532859680284 0.118293649273779 0.664177992839661 GO:0046625 sphingolipid binding 7/2815 28/18639 0.25 1.65532859680284 0.118293649273779 0.664177992839661 GO:0140789 histone phosphatase activity 26/2815 136/18639 0.191176470588235 1.26583951520217 0.118404564328586 0.664177992839661 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 4/2815 13/18639 0.307692307692308 2.03732750375734 0.120238775951838 0.664177992839661 GO:0005338 nucleotide-sugar transmembrane transporter activity 4/2815 13/18639 0.307692307692308 2.03732750375734 0.120238775951838 0.664177992839661 GO:0005542 folic acid binding 4/2815 13/18639 0.307692307692308 2.03732750375734 0.120238775951838 0.664177992839661 GO:0008417 fucosyltransferase activity 4/2815 13/18639 0.307692307692308 2.03732750375734 0.120238775951838 0.664177992839661 GO:0005158 insulin receptor binding 6/2815 23/18639 0.260869565217391 1.72729940535949 0.121747103017609 0.664177992839661 GO:0008171 O-methyltransferase activity 6/2815 23/18639 0.260869565217391 1.72729940535949 0.121747103017609 0.664177992839661 GO:0000900 mRNA regulatory element binding translation repressor activity 5/2815 18/18639 0.277777777777778 1.8392539964476 0.123169158296557 0.664177992839661 GO:0003746 translation elongation factor activity 5/2815 18/18639 0.277777777777778 1.8392539964476 0.123169158296557 0.664177992839661 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 5/2815 18/18639 0.277777777777778 1.8392539964476 0.123169158296557 0.664177992839661 GO:0035615 clathrin adaptor activity 5/2815 18/18639 0.277777777777778 1.8392539964476 0.123169158296557 0.664177992839661 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 9/2815 39/18639 0.230769230769231 1.52799562781801 0.123698111341461 0.66422767350583 GO:0010484 histone H3 acetyltransferase activity 7/2815 29/18639 0.241379310344828 1.59824830036136 0.136700207276406 0.72703840248904 GO:0051861 glycolipid binding 7/2815 29/18639 0.241379310344828 1.59824830036136 0.136700207276406 0.72703840248904 GO:0032934 sterol binding 14/2815 68/18639 0.205882352941176 1.36321178560234 0.137548584492644 0.72703840248904 GO:0003743 translation initiation factor activity 11/2815 51/18639 0.215686274509804 1.42812663253579 0.137670808609036 0.72703840248904 GO:0048029 monosaccharide binding 15/2815 74/18639 0.202702702702703 1.34215832173203 0.140556083079124 0.738358996085212 GO:0004540 RNA nuclease activity 23/2815 121/18639 0.190082644628099 1.25859694963522 0.1415326318632 0.738358996085212 GO:0004622 lysophospholipase activity 6/2815 24/18639 0.25 1.65532859680284 0.142703186254341 0.738358996085212 GO:0043998 histone H2A acetyltransferase activity 6/2815 24/18639 0.25 1.65532859680284 0.142703186254341 0.738358996085212 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 6/2815 24/18639 0.25 1.65532859680284 0.142703186254341 0.738358996085212 GO:0050660 flavin adenine dinucleotide binding 17/2815 86/18639 0.197674418604651 1.30886447189062 0.145032655908777 0.747386025207327 GO:0052689 carboxylic ester hydrolase activity 18/2815 92/18639 0.195652173913043 1.29547455401962 0.146662416363648 0.752271900438344 GO:0097001 ceramide binding 5/2815 19/18639 0.263157894736842 1.74245115452931 0.14746072539125 0.752271900438344 GO:0010485 histone H4 acetyltransferase activity 8/2815 35/18639 0.228571428571429 1.51344328850546 0.147746672151819 0.752271900438344 GO:0030983 mismatched DNA binding 4/2815 14/18639 0.285714285714286 1.89180411063182 0.149177898188895 0.756545055100824 GO:0140713 histone chaperone activity 30/2815 164/18639 0.182926829268293 1.2112160464411 0.150186038665229 0.758647262506573 GO:0003713 transcription coactivator activity 45/2815 256/18639 0.17578125 1.163902919627 0.152561802193058 0.767614107097353 GO:0008106 alcohol dehydrogenase (NADP+) activity 7/2815 30/18639 0.233333333333333 1.54497335701599 0.156406658826923 0.783873372473756 GO:0051219 phosphoprotein binding 18/2815 93/18639 0.193548387096774 1.28154472010543 0.15760257836646 0.78678162168881 GO:0140938 histone H3 methyltransferase activity 10/2815 47/18639 0.212765957446809 1.40879029515135 0.162449279307463 0.801202572395087 GO:0098631 cell adhesion mediator activity 15/2815 76/18639 0.197368421052632 1.30683836589698 0.16503524184342 0.801202572395087 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 6/2815 25/18639 0.24 1.58911545293073 0.165179583159368 0.801202572395087 GO:0017056 structural constituent of nuclear pore 6/2815 25/18639 0.24 1.58911545293073 0.165179583159368 0.801202572395087 GO:0019211 phosphatase activator activity 6/2815 25/18639 0.24 1.58911545293073 0.165179583159368 0.801202572395087 GO:0019706 protein-cysteine S-palmitoyltransferase activity 6/2815 25/18639 0.24 1.58911545293073 0.165179583159368 0.801202572395087 GO:0019707 protein-cysteine S-acyltransferase activity 6/2815 25/18639 0.24 1.58911545293073 0.165179583159368 0.801202572395087 GO:0070063 RNA polymerase binding 12/2815 59/18639 0.203389830508475 1.34670801095824 0.171165123978196 0.801202572395087 GO:0015095 magnesium ion transmembrane transporter activity 5/2815 20/18639 0.25 1.65532859680284 0.173586553674727 0.801202572395087 GO:0016505 peptidase activator activity involved in apoptotic process 5/2815 20/18639 0.25 1.65532859680284 0.173586553674727 0.801202572395087 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 5/2815 20/18639 0.25 1.65532859680284 0.173586553674727 0.801202572395087 GO:0043024 ribosomal small subunit binding 5/2815 20/18639 0.25 1.65532859680284 0.173586553674727 0.801202572395087 GO:0061608 nuclear import signal receptor activity 5/2815 20/18639 0.25 1.65532859680284 0.173586553674727 0.801202572395087 GO:0004520 DNA endonuclease activity 9/2815 42/18639 0.214285714285714 1.41885308297386 0.173666294846733 0.801202572395087 GO:0048487 beta-tubulin binding 9/2815 42/18639 0.214285714285714 1.41885308297386 0.173666294846733 0.801202572395087 GO:0140299 molecular sensor activity 14/2815 71/18639 0.197183098591549 1.30561128761914 0.176351389376741 0.801202572395087 GO:0003714 transcription corepressor activity 36/2815 204/18639 0.176470588235294 1.16846724480201 0.177221572360043 0.801202572395087 GO:0008327 methyl-CpG binding 7/2815 31/18639 0.225806451612903 1.49513550678966 0.177322723698069 0.801202572395087 GO:0008135 translation factor activity, RNA binding 16/2815 83/18639 0.192771084337349 1.27639795416123 0.179300204251123 0.801202572395087 GO:0004953 icosanoid receptor activity 4/2815 15/18639 0.266666666666667 1.7656838365897 0.180450654292839 0.801202572395087 GO:0005041 low-density lipoprotein particle receptor activity 4/2815 15/18639 0.266666666666667 1.7656838365897 0.180450654292839 0.801202572395087 GO:0031386 protein tag activity 4/2815 15/18639 0.266666666666667 1.7656838365897 0.180450654292839 0.801202572395087 GO:0042809 nuclear vitamin D receptor binding 4/2815 15/18639 0.266666666666667 1.7656838365897 0.180450654292839 0.801202572395087 GO:0050700 CARD domain binding 4/2815 15/18639 0.266666666666667 1.7656838365897 0.180450654292839 0.801202572395087 GO:0141047 molecular tag activity 4/2815 15/18639 0.266666666666667 1.7656838365897 0.180450654292839 0.801202572395087 GO:0000182 rDNA binding 3/2815 10/18639 0.3 1.98639431616341 0.182433449582919 0.801202572395087 GO:0001094 TFIID-class transcription factor complex binding 3/2815 10/18639 0.3 1.98639431616341 0.182433449582919 0.801202572395087 GO:0005031 tumor necrosis factor receptor activity 3/2815 10/18639 0.3 1.98639431616341 0.182433449582919 0.801202572395087 GO:0005522 profilin binding 3/2815 10/18639 0.3 1.98639431616341 0.182433449582919 0.801202572395087 GO:0008239 dipeptidyl-peptidase activity 3/2815 10/18639 0.3 1.98639431616341 0.182433449582919 0.801202572395087 GO:0016427 tRNA (cytidine) methyltransferase activity 3/2815 10/18639 0.3 1.98639431616341 0.182433449582919 0.801202572395087 GO:0016783 sulfurtransferase activity 3/2815 10/18639 0.3 1.98639431616341 0.182433449582919 0.801202572395087 GO:0016868 intramolecular phosphotransferase activity 3/2815 10/18639 0.3 1.98639431616341 0.182433449582919 0.801202572395087 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 3/2815 10/18639 0.3 1.98639431616341 0.182433449582919 0.801202572395087 GO:0050815 phosphoserine residue binding 3/2815 10/18639 0.3 1.98639431616341 0.182433449582919 0.801202572395087 GO:0001098 basal transcription machinery binding 12/2815 60/18639 0.2 1.32426287744227 0.186392477769519 0.813002002011759 GO:0001099 basal RNA polymerase II transcription machinery binding 12/2815 60/18639 0.2 1.32426287744227 0.186392477769519 0.813002002011759 GO:0004529 DNA exonuclease activity 6/2815 26/18639 0.230769230769231 1.52799562781801 0.189035246442647 0.816172449167916 GO:0008143 poly(A) binding 6/2815 26/18639 0.230769230769231 1.52799562781801 0.189035246442647 0.816172449167916 GO:0097602 cullin family protein binding 6/2815 26/18639 0.230769230769231 1.52799562781801 0.189035246442647 0.816172449167916 GO:0051117 ATPase binding 16/2815 84/18639 0.19047619047619 1.26120274042121 0.192331828481827 0.824832472482465 GO:0180051 translation factor activity 16/2815 84/18639 0.19047619047619 1.26120274042121 0.192331828481827 0.824832472482465 GO:0022804 active transmembrane transporter activity 76/2815 457/18639 0.166301969365427 1.10113762238088 0.194571687952367 0.831647549174331 GO:0030515 snoRNA binding 7/2815 32/18639 0.21875 1.44841252220249 0.199344840150965 0.845881465007536 GO:0051059 NF-kappaB binding 7/2815 32/18639 0.21875 1.44841252220249 0.199344840150965 0.845881465007536 GO:0098632 cell-cell adhesion mediator activity 11/2815 55/18639 0.2 1.32426287744227 0.199887482341374 0.845881465007536 GO:0070182 DNA polymerase binding 5/2815 21/18639 0.238095238095238 1.57650342552652 0.201315165531801 0.849111490262843 GO:0050840 extracellular matrix binding 13/2815 67/18639 0.194029850746269 1.28473264229474 0.203848827770116 0.856969743059896 GO:0031625 ubiquitin protein ligase binding 51/2815 302/18639 0.16887417218543 1.1181689859198 0.212108641991362 0.885556544077336 GO:0003688 DNA replication origin binding 4/2815 16/18639 0.25 1.65532859680284 0.213641435829543 0.885556544077336 GO:0005521 lamin binding 4/2815 16/18639 0.25 1.65532859680284 0.213641435829543 0.885556544077336 GO:0043023 ribosomal large subunit binding 4/2815 16/18639 0.25 1.65532859680284 0.213641435829543 0.885556544077336 GO:0005044 scavenger receptor activity 6/2815 27/18639 0.222222222222222 1.47140319715808 0.214113436713534 0.885556544077336 GO:0140223 general transcription initiation factor activity 13/2815 68/18639 0.191176470588235 1.26583951520217 0.219519794362974 0.886894968095822 GO:0016758 hexosyltransferase activity 34/2815 197/18639 0.17258883248731 1.14276491962024 0.22371481307302 0.886894968095822 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 3/2815 11/18639 0.272727272727273 1.80581301469401 0.224272267753204 0.886894968095822 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 3/2815 11/18639 0.272727272727273 1.80581301469401 0.224272267753204 0.886894968095822 GO:0004143 ATP-dependent diacylglycerol kinase activity 3/2815 11/18639 0.272727272727273 1.80581301469401 0.224272267753204 0.886894968095822 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 3/2815 11/18639 0.272727272727273 1.80581301469401 0.224272267753204 0.886894968095822 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/2815 11/18639 0.272727272727273 1.80581301469401 0.224272267753204 0.886894968095822 GO:0019206 nucleoside kinase activity 3/2815 11/18639 0.272727272727273 1.80581301469401 0.224272267753204 0.886894968095822 GO:0032404 mismatch repair complex binding 3/2815 11/18639 0.272727272727273 1.80581301469401 0.224272267753204 0.886894968095822 GO:0050998 nitric-oxide synthase binding 3/2815 11/18639 0.272727272727273 1.80581301469401 0.224272267753204 0.886894968095822 GO:0003689 DNA clamp loader activity 28/2815 160/18639 0.175 1.15873001776199 0.226263243140635 0.886894968095822 GO:0032931 histone H3K56 acetyltransferase activity 5/2815 22/18639 0.227272727272727 1.50484417891167 0.23039837981832 0.886894968095822 GO:0043992 histone H3K9 acetyltransferase activity 5/2815 22/18639 0.227272727272727 1.50484417891167 0.23039837981832 0.886894968095822 GO:0043993 histone H3K18 acetyltransferase activity 5/2815 22/18639 0.227272727272727 1.50484417891167 0.23039837981832 0.886894968095822 GO:0043994 histone H3K23 acetyltransferase activity 5/2815 22/18639 0.227272727272727 1.50484417891167 0.23039837981832 0.886894968095822 GO:0043999 histone H2AK5 acetyltransferase activity 5/2815 22/18639 0.227272727272727 1.50484417891167 0.23039837981832 0.886894968095822 GO:0044012 histone H2AK9 acetyltransferase activity 5/2815 22/18639 0.227272727272727 1.50484417891167 0.23039837981832 0.886894968095822 GO:0044014 histone H2BK5 acetyltransferase activity 5/2815 22/18639 0.227272727272727 1.50484417891167 0.23039837981832 0.886894968095822 GO:0044015 histone H2BK12 acetyltransferase activity 5/2815 22/18639 0.227272727272727 1.50484417891167 0.23039837981832 0.886894968095822 GO:0044016 histone H3K4 acetyltransferase activity 5/2815 22/18639 0.227272727272727 1.50484417891167 0.23039837981832 0.886894968095822 GO:0044017 histone H3K27 acetyltransferase activity 5/2815 22/18639 0.227272727272727 1.50484417891167 0.23039837981832 0.886894968095822 GO:0044018 histone H3K36 acetyltransferase activity 5/2815 22/18639 0.227272727272727 1.50484417891167 0.23039837981832 0.886894968095822 GO:0140908 histone H3K122 acetyltransferase activity 5/2815 22/18639 0.227272727272727 1.50484417891167 0.23039837981832 0.886894968095822 GO:0044325 transmembrane transporter binding 24/2815 136/18639 0.176470588235294 1.16846724480201 0.234174178773611 0.898722523941968 GO:0044183 protein folding chaperone 14/2815 75/18639 0.186666666666667 1.23597868561279 0.235399883972358 0.900721711726567 GO:0045499 chemorepellent activity 6/2815 28/18639 0.214285714285714 1.41885308297386 0.240246106015286 0.916520965634433 GO:0016831 carboxy-lyase activity 7/2815 34/18639 0.205882352941176 1.36321178560234 0.24624163394613 0.922558490441208 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/2815 17/18639 0.235294117647059 1.55795632640267 0.248325603060857 0.922558490441208 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 4/2815 17/18639 0.235294117647059 1.55795632640267 0.248325603060857 0.922558490441208 GO:0016018 cyclosporin A binding 4/2815 17/18639 0.235294117647059 1.55795632640267 0.248325603060857 0.922558490441208 GO:0017110 nucleoside diphosphate phosphatase activity 4/2815 17/18639 0.235294117647059 1.55795632640267 0.248325603060857 0.922558490441208 GO:0019198 transmembrane receptor protein phosphatase activity 4/2815 17/18639 0.235294117647059 1.55795632640267 0.248325603060857 0.922558490441208 GO:0030169 low-density lipoprotein particle binding 4/2815 17/18639 0.235294117647059 1.55795632640267 0.248325603060857 0.922558490441208 GO:0032183 SUMO binding 4/2815 17/18639 0.235294117647059 1.55795632640267 0.248325603060857 0.922558490441208 GO:0046965 nuclear retinoid X receptor binding 4/2815 17/18639 0.235294117647059 1.55795632640267 0.248325603060857 0.922558490441208 GO:0004177 aminopeptidase activity 8/2815 40/18639 0.2 1.32426287744227 0.24987393951718 0.92461326944562 GO:0003887 DNA-directed DNA polymerase activity 5/2815 23/18639 0.217391304347826 1.43941617113291 0.260579290040739 0.92461326944562 GO:0044013 histone H2B acetyltransferase activity 5/2815 23/18639 0.217391304347826 1.43941617113291 0.260579290040739 0.92461326944562 GO:0070577 lysine-acetylated histone binding 5/2815 23/18639 0.217391304347826 1.43941617113291 0.260579290040739 0.92461326944562 GO:0000510 H3-H4 histone complex chaperone activity 26/2815 151/18639 0.172185430463576 1.14009386799666 0.263992345032977 0.92461326944562 GO:0140584 chromatin extrusion motor activity 26/2815 151/18639 0.172185430463576 1.14009386799666 0.263992345032977 0.92461326944562 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 26/2815 151/18639 0.172185430463576 1.14009386799666 0.263992345032977 0.92461326944562 GO:0140849 ATP-dependent H2AZ histone chaperone activity 26/2815 151/18639 0.172185430463576 1.14009386799666 0.263992345032977 0.92461326944562 GO:0032182 ubiquitin-like protein binding 21/2815 120/18639 0.175 1.15873001776199 0.265569589007918 0.92461326944562 GO:0001540 amyloid-beta binding 15/2815 83/18639 0.180722891566265 1.19662308202615 0.265662639688598 0.92461326944562 GO:0016417 S-acyltransferase activity 6/2815 29/18639 0.206896551724138 1.36992711459546 0.267258079599341 0.92461326944562 GO:0000340 RNA 7-methylguanosine cap binding 3/2815 12/18639 0.25 1.65532859680284 0.267689287711173 0.92461326944562 GO:0004032 aldose reductase (NADPH) activity 3/2815 12/18639 0.25 1.65532859680284 0.267689287711173 0.92461326944562 GO:0004300 enoyl-CoA hydratase activity 3/2815 12/18639 0.25 1.65532859680284 0.267689287711173 0.92461326944562 GO:0005095 GTPase inhibitor activity 3/2815 12/18639 0.25 1.65532859680284 0.267689287711173 0.92461326944562 GO:0005165 neurotrophin receptor binding 3/2815 12/18639 0.25 1.65532859680284 0.267689287711173 0.92461326944562 GO:0016801 hydrolase activity, acting on ether bonds 3/2815 12/18639 0.25 1.65532859680284 0.267689287711173 0.92461326944562 GO:0016803 ether hydrolase activity 3/2815 12/18639 0.25 1.65532859680284 0.267689287711173 0.92461326944562 GO:0016840 carbon-nitrogen lyase activity 3/2815 12/18639 0.25 1.65532859680284 0.267689287711173 0.92461326944562 GO:0043047 single-stranded telomeric DNA binding 3/2815 12/18639 0.25 1.65532859680284 0.267689287711173 0.92461326944562 GO:0045295 gamma-catenin binding 3/2815 12/18639 0.25 1.65532859680284 0.267689287711173 0.92461326944562 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 3/2815 12/18639 0.25 1.65532859680284 0.267689287711173 0.92461326944562 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 3/2815 12/18639 0.25 1.65532859680284 0.267689287711173 0.92461326944562 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 3/2815 12/18639 0.25 1.65532859680284 0.267689287711173 0.92461326944562 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 3/2815 12/18639 0.25 1.65532859680284 0.267689287711173 0.92461326944562 GO:1990247 N6-methyladenosine-containing RNA reader activity 3/2815 12/18639 0.25 1.65532859680284 0.267689287711173 0.92461326944562 GO:0038024 cargo receptor activity 12/2815 65/18639 0.184615384615385 1.22239650225441 0.270832228217251 0.925986741127761 GO:0061631 ubiquitin conjugating enzyme activity 7/2815 35/18639 0.2 1.32426287744227 0.270865374394707 0.925986741127761 GO:0045309 protein phosphorylated amino acid binding 11/2815 59/18639 0.186440677966102 1.23448234337839 0.27206534988504 0.925986741127761 GO:0001727 lipid kinase activity 8/2815 41/18639 0.195121951219512 1.29196378287051 0.272612426271633 0.925986741127761 GO:0016251 RNA polymerase II general transcription initiation factor activity 10/2815 53/18639 0.188679245283019 1.24930460136064 0.272894739238615 0.925986741127761 GO:0140296 general transcription initiation factor binding 10/2815 53/18639 0.188679245283019 1.24930460136064 0.272894739238615 0.925986741127761 GO:0005504 fatty acid binding 9/2815 47/18639 0.191489361702128 1.26791126563622 0.273158843040036 0.925986741127761 GO:0015616 DNA translocase activity 26/2815 152/18639 0.171052631578947 1.13259325044405 0.275667279510908 0.927230524683719 GO:0140674 ATP-dependent histone chaperone activity 26/2815 152/18639 0.171052631578947 1.13259325044405 0.275667279510908 0.927230524683719 GO:0042826 histone deacetylase binding 22/2815 127/18639 0.173228346456693 1.14699934266654 0.275702346932561 0.927230524683719 GO:0042393 histone binding 41/2815 247/18639 0.165991902834008 1.09908457439541 0.279178192174748 0.936455983200337 GO:0008525 phosphatidylcholine transporter activity 4/2815 18/18639 0.222222222222222 1.47140319715808 0.284084587279229 0.940570213841592 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4/2815 18/18639 0.222222222222222 1.47140319715808 0.284084587279229 0.940570213841592 GO:0030228 lipoprotein particle receptor activity 4/2815 18/18639 0.222222222222222 1.47140319715808 0.284084587279229 0.940570213841592 GO:0070064 proline-rich region binding 4/2815 18/18639 0.222222222222222 1.47140319715808 0.284084587279229 0.940570213841592 GO:1990381 ubiquitin-specific protease binding 4/2815 18/18639 0.222222222222222 1.47140319715808 0.284084587279229 0.940570213841592 GO:0061775 cohesin loader activity 26/2815 153/18639 0.169934640522876 1.12519068017971 0.28753240135565 0.943674373593246 GO:0008094 ATP-dependent activity, acting on DNA 35/2815 210/18639 0.166666666666667 1.10355239786856 0.289414465060668 0.943674373593246 GO:0001091 RNA polymerase II general transcription initiation factor binding 5/2815 24/18639 0.208333333333333 1.3794404973357 0.29159931735295 0.943674373593246 GO:0005540 hyaluronic acid binding 5/2815 24/18639 0.208333333333333 1.3794404973357 0.29159931735295 0.943674373593246 GO:0035035 histone acetyltransferase binding 5/2815 24/18639 0.208333333333333 1.3794404973357 0.29159931735295 0.943674373593246 GO:0070300 phosphatidic acid binding 5/2815 24/18639 0.208333333333333 1.3794404973357 0.29159931735295 0.943674373593246 GO:0140033 acetylation-dependent protein binding 5/2815 24/18639 0.208333333333333 1.3794404973357 0.29159931735295 0.943674373593246 GO:0015485 cholesterol binding 10/2815 54/18639 0.185185185185185 1.22616933096507 0.293259454285596 0.943674373593246 GO:0031210 phosphatidylcholine binding 6/2815 30/18639 0.2 1.32426287744227 0.294970934792446 0.943674373593246 GO:0033612 receptor serine/threonine kinase binding 6/2815 30/18639 0.2 1.32426287744227 0.294970934792446 0.943674373593246 GO:0035925 mRNA 3'-UTR AU-rich region binding 6/2815 30/18639 0.2 1.32426287744227 0.294970934792446 0.943674373593246 GO:0031492 nucleosomal DNA binding 8/2815 42/18639 0.19047619047619 1.26120274042121 0.295893868959845 0.943674373593246 GO:0043175 RNA polymerase core enzyme binding 8/2815 42/18639 0.19047619047619 1.26120274042121 0.295893868959845 0.943674373593246 GO:0004033 aldo-keto reductase (NADPH) activity 7/2815 36/18639 0.194444444444444 1.28747779751332 0.296098140697098 0.943674373593246 GO:0016409 palmitoyltransferase activity 7/2815 36/18639 0.194444444444444 1.28747779751332 0.296098140697098 0.943674373593246 GO:0016835 carbon-oxygen lyase activity 14/2815 79/18639 0.177215189873418 1.17339748634125 0.301131004296344 0.954951423053914 GO:0046332 SMAD binding 14/2815 79/18639 0.177215189873418 1.17339748634125 0.301131004296344 0.954951423053914 GO:0016836 hydro-lyase activity 11/2815 61/18639 0.180327868852459 1.19400751244795 0.310894070661505 0.956152578637994 GO:0002020 protease binding 23/2815 136/18639 0.169117647058824 1.11978110960192 0.311228436150564 0.956152578637994 GO:0002161 aminoacyl-tRNA editing activity 3/2815 13/18639 0.230769230769231 1.52799562781801 0.311924441238974 0.956152578637994 GO:0005035 death receptor activity 3/2815 13/18639 0.230769230769231 1.52799562781801 0.311924441238974 0.956152578637994 GO:0008253 5'-nucleotidase activity 3/2815 13/18639 0.230769230769231 1.52799562781801 0.311924441238974 0.956152578637994 GO:0017154 semaphorin receptor activity 3/2815 13/18639 0.230769230769231 1.52799562781801 0.311924441238974 0.956152578637994 GO:0019855 calcium channel inhibitor activity 3/2815 13/18639 0.230769230769231 1.52799562781801 0.311924441238974 0.956152578637994 GO:0046975 histone H3K36 methyltransferase activity 3/2815 13/18639 0.230769230769231 1.52799562781801 0.311924441238974 0.956152578637994 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 3/2815 13/18639 0.230769230769231 1.52799562781801 0.311924441238974 0.956152578637994 GO:0016763 pentosyltransferase activity 9/2815 49/18639 0.183673469387755 1.21615978540617 0.316953341537367 0.956152578637994 GO:0008200 ion channel inhibitor activity 8/2815 43/18639 0.186046511627907 1.23187244413235 0.319614725875274 0.956152578637994 GO:0048156 tau protein binding 8/2815 43/18639 0.186046511627907 1.23187244413235 0.319614725875274 0.956152578637994 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 4/2815 19/18639 0.210526315789474 1.39396092362345 0.320517617116023 0.956152578637994 GO:0008381 mechanosensitive monoatomic ion channel activity 4/2815 19/18639 0.210526315789474 1.39396092362345 0.320517617116023 0.956152578637994 GO:0008574 plus-end-directed microtubule motor activity 4/2815 19/18639 0.210526315789474 1.39396092362345 0.320517617116023 0.956152578637994 GO:0042577 lipid phosphatase activity 4/2815 19/18639 0.210526315789474 1.39396092362345 0.320517617116023 0.956152578637994 GO:0042800 histone H3K4 methyltransferase activity 4/2815 19/18639 0.210526315789474 1.39396092362345 0.320517617116023 0.956152578637994 GO:0050145 nucleoside monophosphate kinase activity 4/2815 19/18639 0.210526315789474 1.39396092362345 0.320517617116023 0.956152578637994 GO:0070003 threonine-type peptidase activity 4/2815 19/18639 0.210526315789474 1.39396092362345 0.320517617116023 0.956152578637994 GO:0120227 acyl-CoA binding 4/2815 19/18639 0.210526315789474 1.39396092362345 0.320517617116023 0.956152578637994 GO:0044389 ubiquitin-like protein ligase binding 52/2815 322/18639 0.161490683229814 1.06928058427016 0.321188138799283 0.956152578637994 GO:0019213 deacetylase activity 7/2815 37/18639 0.189189189189189 1.25268110028323 0.321806996929722 0.956152578637994 GO:0022829 wide pore channel activity 7/2815 37/18639 0.189189189189189 1.25268110028323 0.321806996929722 0.956152578637994 GO:0003707 nuclear steroid receptor activity 5/2815 25/18639 0.2 1.32426287744227 0.323204250901345 0.956152578637994 GO:0042974 nuclear retinoic acid receptor binding 5/2815 25/18639 0.2 1.32426287744227 0.323204250901345 0.956152578637994 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 5/2815 25/18639 0.2 1.32426287744227 0.323204250901345 0.956152578637994 GO:0016878 acid-thiol ligase activity 6/2815 31/18639 0.193548387096774 1.28154472010543 0.323206505455096 0.956152578637994 GO:0017147 Wnt-protein binding 6/2815 31/18639 0.193548387096774 1.28154472010543 0.323206505455096 0.956152578637994 GO:0047499 calcium-independent phospholipase A2 activity 6/2815 31/18639 0.193548387096774 1.28154472010543 0.323206505455096 0.956152578637994 GO:0016248 channel inhibitor activity 8/2815 44/18639 0.181818181818182 1.20387534312934 0.343671169051557 1 GO:0140658 ATP-dependent chromatin remodeler activity 26/2815 158/18639 0.164556962025316 1.08958338017402 0.349258971704221 1 GO:0008378 galactosyltransferase activity 6/2815 32/18639 0.1875 1.24149644760213 0.351789966679126 1 GO:0031369 translation initiation factor binding 6/2815 32/18639 0.1875 1.24149644760213 0.351789966679126 1 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 6/2815 32/18639 0.1875 1.24149644760213 0.351789966679126 1 GO:0047498 calcium-dependent phospholipase A2 activity 6/2815 32/18639 0.1875 1.24149644760213 0.351789966679126 1 GO:0070717 poly-purine tract binding 6/2815 32/18639 0.1875 1.24149644760213 0.351789966679126 1 GO:0120015 sterol transfer activity 6/2815 32/18639 0.1875 1.24149644760213 0.351789966679126 1 GO:0034237 protein kinase A regulatory subunit binding 5/2815 26/18639 0.192307692307692 1.27332968984834 0.35514925196294 1 GO:0051139 metal cation:proton antiporter activity 5/2815 26/18639 0.192307692307692 1.27332968984834 0.35514925196294 1 GO:0070006 metalloaminopeptidase activity 5/2815 26/18639 0.192307692307692 1.27332968984834 0.35514925196294 1 GO:0120014 phospholipid transfer activity 5/2815 26/18639 0.192307692307692 1.27332968984834 0.35514925196294 1 GO:0008174 mRNA methyltransferase activity 3/2815 14/18639 0.214285714285714 1.41885308297386 0.356309862070813 1 GO:0008195 phosphatidate phosphatase activity 3/2815 14/18639 0.214285714285714 1.41885308297386 0.356309862070813 1 GO:0008494 translation activator activity 3/2815 14/18639 0.214285714285714 1.41885308297386 0.356309862070813 1 GO:0015386 potassium:proton antiporter activity 3/2815 14/18639 0.214285714285714 1.41885308297386 0.356309862070813 1 GO:0015926 glucosidase activity 3/2815 14/18639 0.214285714285714 1.41885308297386 0.356309862070813 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 3/2815 14/18639 0.214285714285714 1.41885308297386 0.356309862070813 1 GO:0042813 Wnt receptor activity 3/2815 14/18639 0.214285714285714 1.41885308297386 0.356309862070813 1 GO:0070742 C2H2 zinc finger domain binding 3/2815 14/18639 0.214285714285714 1.41885308297386 0.356309862070813 1 GO:0098847 sequence-specific single stranded DNA binding 3/2815 14/18639 0.214285714285714 1.41885308297386 0.356309862070813 1 GO:0031418 L-ascorbic acid binding 4/2815 20/18639 0.2 1.32426287744227 0.357250382976347 1 GO:0140034 methylation-dependent protein binding 13/2815 76/18639 0.171052631578947 1.13259325044405 0.359110594957616 1 GO:0015631 tubulin binding 61/2815 385/18639 0.158441558441558 1.04909137044128 0.362145247242485 1 GO:1901681 sulfur compound binding 44/2815 275/18639 0.16 1.05941030195382 0.362904597151411 1 GO:0005496 steroid binding 18/2815 108/18639 0.166666666666667 1.10355239786856 0.363899829733301 1 GO:0141110 transporter inhibitor activity 8/2815 45/18639 0.177777777777778 1.17712255772647 0.367960374220274 1 GO:0017116 single-stranded DNA helicase activity 10/2815 58/18639 0.172413793103448 1.14160592882955 0.377868072643855 1 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 6/2815 33/18639 0.181818181818182 1.20387534312934 0.380552476712888 1 GO:0005385 zinc ion transmembrane transporter activity 5/2815 27/18639 0.185185185185185 1.22616933096507 0.387202846337804 1 GO:0160215 deacylase activity 11/2815 65/18639 0.169230769230769 1.12053012706654 0.391734470827471 1 GO:0004386 helicase activity 25/2815 155/18639 0.161290322580645 1.06795393342119 0.393661892435869 1 GO:0008373 sialyltransferase activity 4/2815 21/18639 0.19047619047619 1.26120274042121 0.393941022375064 1 GO:0010314 phosphatidylinositol-5-phosphate binding 4/2815 21/18639 0.19047619047619 1.26120274042121 0.393941022375064 1 GO:1904047 S-adenosyl-L-methionine binding 4/2815 21/18639 0.19047619047619 1.26120274042121 0.393941022375064 1 GO:0019838 growth factor binding 22/2815 136/18639 0.161764705882353 1.07109497440184 0.398676966831698 1 GO:0004879 nuclear receptor activity 10/2815 59/18639 0.169491525423729 1.12225667579854 0.399460465043613 1 GO:0008242 omega peptidase activity 3/2815 15/18639 0.2 1.32426287744227 0.400274664015307 1 GO:0008252 nucleotidase activity 3/2815 15/18639 0.2 1.32426287744227 0.400274664015307 1 GO:0010181 FMN binding 3/2815 15/18639 0.2 1.32426287744227 0.400274664015307 1 GO:0120283 protein serine/threonine kinase binding 3/2815 15/18639 0.2 1.32426287744227 0.400274664015307 1 GO:0050997 quaternary ammonium group binding 7/2815 40/18639 0.175 1.15873001776199 0.40048402325866 1 GO:0140662 ATP-dependent protein folding chaperone 7/2815 40/18639 0.175 1.15873001776199 0.40048402325866 1 GO:0005518 collagen binding 12/2815 72/18639 0.166666666666667 1.10355239786856 0.404070010495541 1 GO:0019825 oxygen binding 6/2815 34/18639 0.176470588235294 1.16846724480201 0.409333371591479 1 GO:0004725 protein tyrosine phosphatase activity 16/2815 98/18639 0.163265306122449 1.08103092036104 0.40942847822424 1 GO:0043177 organic acid binding 30/2815 189/18639 0.158730158730159 1.05100228368434 0.413921978395875 1 GO:0001784 phosphotyrosine residue binding 8/2815 47/18639 0.170212765957447 1.12703223612108 0.41683765478121 1 GO:0061749 forked DNA-dependent helicase activity 8/2815 47/18639 0.170212765957447 1.12703223612108 0.41683765478121 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 8/2815 47/18639 0.170212765957447 1.12703223612108 0.41683765478121 1 GO:0019789 SUMO transferase activity 5/2815 28/18639 0.178571428571429 1.18237756914489 0.419149963799221 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 10/2815 60/18639 0.166666666666667 1.10355239786856 0.421092950959937 1 GO:0098531 ligand-modulated transcription factor activity 10/2815 60/18639 0.166666666666667 1.10355239786856 0.421092950959937 1 GO:0019902 phosphatase binding 30/2815 190/18639 0.157894736842105 1.04547069271758 0.426054568079052 1 GO:0001530 lipopolysaccharide binding 7/2815 41/18639 0.170731707317073 1.1304683100117 0.426810528520695 1 GO:0140035 ubiquitin-like protein reader activity 4/2815 22/18639 0.181818181818182 1.20387534312934 0.430283831832118 1 GO:0008017 microtubule binding 43/2815 276/18639 0.155797101449275 1.03158158931192 0.437624700516543 1 GO:0000175 3'-5'-RNA exonuclease activity 6/2815 35/18639 0.171428571428571 1.13508246637909 0.437981922735639 1 GO:0004623 phospholipase A2 activity 6/2815 35/18639 0.171428571428571 1.13508246637909 0.437981922735639 1 GO:0016229 steroid dehydrogenase activity 6/2815 35/18639 0.171428571428571 1.13508246637909 0.437981922735639 1 GO:0140566 histone reader activity 6/2815 35/18639 0.171428571428571 1.13508246637909 0.437981922735639 1 GO:0009378 four-way junction helicase activity 8/2815 48/18639 0.166666666666667 1.10355239786856 0.441234922889369 1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 8/2815 48/18639 0.166666666666667 1.10355239786856 0.441234922889369 1 GO:0036121 double-stranded DNA helicase activity 8/2815 48/18639 0.166666666666667 1.10355239786856 0.441234922889369 1 GO:0043138 3'-5' DNA helicase activity 8/2815 48/18639 0.166666666666667 1.10355239786856 0.441234922889369 1 GO:0043130 ubiquitin binding 16/2815 100/18639 0.16 1.05941030195382 0.443089180788363 1 GO:0003678 DNA helicase activity 12/2815 74/18639 0.162162162162162 1.07372665738563 0.44327143792897 1 GO:0035064 methylated histone binding 12/2815 74/18639 0.162162162162162 1.07372665738563 0.44327143792897 1 GO:0000062 fatty-acyl-CoA binding 3/2815 16/18639 0.1875 1.24149644760213 0.443343870519714 1 GO:0005149 interleukin-1 receptor binding 3/2815 16/18639 0.1875 1.24149644760213 0.443343870519714 1 GO:0005159 insulin-like growth factor receptor binding 3/2815 16/18639 0.1875 1.24149644760213 0.443343870519714 1 GO:0005324 long-chain fatty acid transmembrane transporter activity 3/2815 16/18639 0.1875 1.24149644760213 0.443343870519714 1 GO:0015562 efflux transmembrane transporter activity 3/2815 16/18639 0.1875 1.24149644760213 0.443343870519714 1 GO:0030275 LRR domain binding 3/2815 16/18639 0.1875 1.24149644760213 0.443343870519714 1 GO:0031435 mitogen-activated protein kinase kinase kinase binding 3/2815 16/18639 0.1875 1.24149644760213 0.443343870519714 1 GO:0034450 ubiquitin-ubiquitin ligase activity 3/2815 16/18639 0.1875 1.24149644760213 0.443343870519714 1 GO:0070411 I-SMAD binding 3/2815 16/18639 0.1875 1.24149644760213 0.443343870519714 1 GO:1901981 phosphatidylinositol phosphate binding 29/2815 185/18639 0.156756756756757 1.03793576880611 0.444822823851475 1 GO:0035250 UDP-galactosyltransferase activity 5/2815 29/18639 0.172413793103448 1.14160592882955 0.450794106340863 1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 5/2815 29/18639 0.172413793103448 1.14160592882955 0.450794106340863 1 GO:0008374 O-acyltransferase activity 9/2815 55/18639 0.163636363636364 1.08348780881641 0.453517286265044 1 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0004955 prostaglandin receptor activity 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0005131 growth hormone receptor binding 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0005528 FK506 binding 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0015203 polyamine transmembrane transporter activity 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0030957 Tat protein binding 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0031957 very long-chain fatty acid-CoA ligase activity 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0035256 G protein-coupled glutamate receptor binding 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0045322 unmethylated CpG binding 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0050308 sugar-phosphatase activity 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0098505 G-rich strand telomeric DNA binding 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0141109 transporter activator activity 2/2815 10/18639 0.2 1.32426287744227 0.459509647127973 1 GO:0004197 cysteine-type endopeptidase activity 14/2815 88/18639 0.159090909090909 1.05339092523817 0.461362754502278 1 GO:0004602 glutathione peroxidase activity 4/2815 23/18639 0.173913043478261 1.15153293690632 0.466011103788197 1 GO:0099186 structural constituent of postsynapse 4/2815 23/18639 0.173913043478261 1.15153293690632 0.466011103788197 1 GO:0000993 RNA polymerase II complex binding 6/2815 36/18639 0.166666666666667 1.10355239786856 0.466358679143347 1 GO:0031406 carboxylic acid binding 29/2815 187/18639 0.155080213903743 1.02683485149267 0.469582222803741 1 GO:0005178 integrin binding 25/2815 161/18639 0.15527950310559 1.02815440795208 0.473639875367236 1 GO:0008238 exopeptidase activity 16/2815 102/18639 0.156862745098039 1.03863755093512 0.476673066994748 1 GO:0008375 acetylglucosaminyltransferase activity 7/2815 43/18639 0.162790697674419 1.0778883886158 0.478928692152395 1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 14/2815 89/18639 0.157303370786517 1.04155507214561 0.479320989142505 1 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 14/2815 89/18639 0.157303370786517 1.04155507214561 0.479320989142505 1 GO:0001968 fibronectin binding 5/2815 30/18639 0.166666666666667 1.10355239786856 0.481958740650546 1 GO:0051721 protein phosphatase 2A binding 5/2815 30/18639 0.166666666666667 1.10355239786856 0.481958740650546 1 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 3/2815 17/18639 0.176470588235294 1.16846724480201 0.485133499260898 1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/2815 17/18639 0.176470588235294 1.16846724480201 0.485133499260898 1 GO:0008429 phosphatidylethanolamine binding 3/2815 17/18639 0.176470588235294 1.16846724480201 0.485133499260898 1 GO:0015278 intracellularly gated calcium channel activity 3/2815 17/18639 0.176470588235294 1.16846724480201 0.485133499260898 1 GO:0036041 long-chain fatty acid binding 3/2815 17/18639 0.176470588235294 1.16846724480201 0.485133499260898 1 GO:0045125 bioactive lipid receptor activity 3/2815 17/18639 0.176470588235294 1.16846724480201 0.485133499260898 1 GO:0051787 misfolded protein binding 3/2815 17/18639 0.176470588235294 1.16846724480201 0.485133499260898 1 GO:0070403 NAD+ binding 3/2815 17/18639 0.176470588235294 1.16846724480201 0.485133499260898 1 GO:0070492 oligosaccharide binding 3/2815 17/18639 0.176470588235294 1.16846724480201 0.485133499260898 1 GO:1901567 fatty acid derivative binding 3/2815 17/18639 0.176470588235294 1.16846724480201 0.485133499260898 1 GO:0016779 nucleotidyltransferase activity 21/2815 136/18639 0.154411764705882 1.02240883920176 0.492741767721845 1 GO:0042805 actinin binding 6/2815 37/18639 0.162162162162162 1.07372665738563 0.49433642408792 1 GO:0140793 histone H2AXY142 phosphatase activity 14/2815 90/18639 0.155555555555556 1.02998223801066 0.497175548033167 1 GO:0051020 GTPase binding 48/2815 315/18639 0.152380952380952 1.00896219233697 0.497523949781617 1 GO:0042625 ATPase-coupled ion transmembrane transporter activity 4/2815 24/18639 0.166666666666667 1.10355239786856 0.500893461075248 1 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4/2815 24/18639 0.166666666666667 1.10355239786856 0.500893461075248 1 GO:0046961 proton-transporting ATPase activity, rotational mechanism 4/2815 24/18639 0.166666666666667 1.10355239786856 0.500893461075248 1 GO:0003724 RNA helicase activity 12/2815 77/18639 0.155844155844156 1.03189315125372 0.501561869291247 1 GO:0016798 hydrolase activity, acting on glycosyl bonds 20/2815 130/18639 0.153846153846154 1.01866375187867 0.50176452393877 1 GO:0001046 core promoter sequence-specific DNA binding 7/2815 44/18639 0.159090909090909 1.05339092523817 0.504517953279581 1 GO:0001223 transcription coactivator binding 7/2815 44/18639 0.159090909090909 1.05339092523817 0.504517953279581 1 GO:0002162 dystroglycan binding 2/2815 11/18639 0.181818181818182 1.20387534312934 0.511784620322366 1 GO:0004954 prostanoid receptor activity 2/2815 11/18639 0.181818181818182 1.20387534312934 0.511784620322366 1 GO:0005536 D-glucose binding 2/2815 11/18639 0.181818181818182 1.20387534312934 0.511784620322366 1 GO:0008172 S-methyltransferase activity 2/2815 11/18639 0.181818181818182 1.20387534312934 0.511784620322366 1 GO:0008526 phosphatidylinositol transfer activity 2/2815 11/18639 0.181818181818182 1.20387534312934 0.511784620322366 1 GO:0010854 adenylate cyclase regulator activity 2/2815 11/18639 0.181818181818182 1.20387534312934 0.511784620322366 1 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/2815 11/18639 0.181818181818182 1.20387534312934 0.511784620322366 1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/2815 11/18639 0.181818181818182 1.20387534312934 0.511784620322366 1 GO:0019107 myristoyltransferase activity 2/2815 11/18639 0.181818181818182 1.20387534312934 0.511784620322366 1 GO:0019203 carbohydrate phosphatase activity 2/2815 11/18639 0.181818181818182 1.20387534312934 0.511784620322366 1 GO:0032794 GTPase activating protein binding 2/2815 11/18639 0.181818181818182 1.20387534312934 0.511784620322366 1 GO:0034511 U3 snoRNA binding 2/2815 11/18639 0.181818181818182 1.20387534312934 0.511784620322366 1 GO:0045294 alpha-catenin binding 2/2815 11/18639 0.181818181818182 1.20387534312934 0.511784620322366 1 GO:0048185 activin binding 2/2815 11/18639 0.181818181818182 1.20387534312934 0.511784620322366 1 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/2815 11/18639 0.181818181818182 1.20387534312934 0.511784620322366 1 GO:0072341 modified amino acid binding 14/2815 91/18639 0.153846153846154 1.01866375187867 0.5148931856325 1 GO:0035091 phosphatidylinositol binding 43/2815 284/18639 0.151408450704225 1.00252295299327 0.518571762438897 1 GO:0005109 frizzled binding 6/2815 38/18639 0.157894736842105 1.04547069271758 0.521800781849613 1 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 6/2815 38/18639 0.157894736842105 1.04547069271758 0.521800781849613 1 GO:0008308 voltage-gated monoatomic anion channel activity 3/2815 18/18639 0.166666666666667 1.10355239786856 0.525343281657232 1 GO:0016854 racemase and epimerase activity 3/2815 18/18639 0.166666666666667 1.10355239786856 0.525343281657232 1 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 3/2815 18/18639 0.166666666666667 1.10355239786856 0.525343281657232 1 GO:0017128 phospholipid scramblase activity 3/2815 18/18639 0.166666666666667 1.10355239786856 0.525343281657232 1 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 3/2815 18/18639 0.166666666666667 1.10355239786856 0.525343281657232 1 GO:0070628 proteasome binding 3/2815 18/18639 0.166666666666667 1.10355239786856 0.525343281657232 1 GO:0046915 transition metal ion transmembrane transporter activity 7/2815 45/18639 0.155555555555556 1.02998223801066 0.529673296790506 1 GO:0008201 heparin binding 26/2815 172/18639 0.151162790697674 1.00089636085753 0.530915487265416 1 GO:0043178 alcohol binding 14/2815 92/18639 0.152173913043478 1.00759131979303 0.532442224836519 1 GO:0061659 ubiquitin-like protein ligase activity 56/2815 372/18639 0.150537634408602 0.996757004526442 0.533280112338403 1 GO:0120020 cholesterol transfer activity 4/2815 25/18639 0.16 1.05941030195382 0.534739024917895 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 8/2815 52/18639 0.153846153846154 1.01866375187867 0.536551724825418 1 GO:0030159 signaling receptor complex adaptor activity 8/2815 52/18639 0.153846153846154 1.01866375187867 0.536551724825418 1 GO:0008186 ATP-dependent activity, acting on RNA 12/2815 79/18639 0.151898734177215 1.00576927400679 0.53957686240247 1 GO:0061630 ubiquitin protein ligase activity 53/2815 353/18639 0.15014164305949 0.994135021309356 0.54193300329895 1 GO:0071813 lipoprotein particle binding 5/2815 32/18639 0.15625 1.03458037300178 0.542246914792365 1 GO:0071814 protein-lipid complex binding 5/2815 32/18639 0.15625 1.03458037300178 0.542246914792365 1 GO:0015459 potassium channel regulator activity 9/2815 59/18639 0.152542372881356 1.01003100821868 0.542700517903663 1 GO:0000217 DNA secondary structure binding 6/2815 39/18639 0.153846153846154 1.01866375187867 0.548650513348833 1 GO:0051213 dioxygenase activity 14/2815 93/18639 0.150537634408602 0.996757004526442 0.549792671331463 1 GO:0043539 protein serine/threonine kinase activator activity 11/2815 73/18639 0.150684931506849 0.997732304922261 0.553433242897705 1 GO:0004126 cytidine deaminase activity 2/2815 12/18639 0.166666666666667 1.10355239786856 0.560603686844605 1 GO:0004859 phospholipase inhibitor activity 2/2815 12/18639 0.166666666666667 1.10355239786856 0.560603686844605 1 GO:0004875 complement receptor activity 2/2815 12/18639 0.166666666666667 1.10355239786856 0.560603686844605 1 GO:0005527 macrolide binding 2/2815 12/18639 0.166666666666667 1.10355239786856 0.560603686844605 1 GO:0008504 monoamine transmembrane transporter activity 2/2815 12/18639 0.166666666666667 1.10355239786856 0.560603686844605 1 GO:0031543 peptidyl-proline dioxygenase activity 2/2815 12/18639 0.166666666666667 1.10355239786856 0.560603686844605 1 GO:0035251 UDP-glucosyltransferase activity 2/2815 12/18639 0.166666666666667 1.10355239786856 0.560603686844605 1 GO:0035497 cAMP response element binding 2/2815 12/18639 0.166666666666667 1.10355239786856 0.560603686844605 1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/2815 12/18639 0.166666666666667 1.10355239786856 0.560603686844605 1 GO:0070410 co-SMAD binding 2/2815 12/18639 0.166666666666667 1.10355239786856 0.560603686844605 1 GO:0097677 STAT family protein binding 2/2815 12/18639 0.166666666666667 1.10355239786856 0.560603686844605 1 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/2815 12/18639 0.166666666666667 1.10355239786856 0.560603686844605 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 2/2815 12/18639 0.166666666666667 1.10355239786856 0.560603686844605 1 GO:0005520 insulin-like growth factor binding 3/2815 19/18639 0.157894736842105 1.04547069271758 0.563748093758708 1 GO:0008301 DNA binding, bending 3/2815 19/18639 0.157894736842105 1.04547069271758 0.563748093758708 1 GO:0015245 fatty acid transmembrane transporter activity 3/2815 19/18639 0.157894736842105 1.04547069271758 0.563748093758708 1 GO:0022821 solute:potassium antiporter activity 3/2815 19/18639 0.157894736842105 1.04547069271758 0.563748093758708 1 GO:0046527 glucosyltransferase activity 3/2815 19/18639 0.157894736842105 1.04547069271758 0.563748093758708 1 GO:0140036 ubiquitin-modified protein reader activity 3/2815 19/18639 0.157894736842105 1.04547069271758 0.563748093758708 1 GO:1990380 K48-linked deubiquitinase activity 3/2815 19/18639 0.157894736842105 1.04547069271758 0.563748093758708 1 GO:0050681 nuclear androgen receptor binding 4/2815 26/18639 0.153846153846154 1.01866375187867 0.567391710909705 1 GO:0052742 phosphatidylinositol kinase activity 4/2815 26/18639 0.153846153846154 1.01866375187867 0.567391710909705 1 GO:0070412 R-SMAD binding 4/2815 26/18639 0.153846153846154 1.01866375187867 0.567391710909705 1 GO:0071889 14-3-3 protein binding 5/2815 33/18639 0.151515151515152 1.00322945260778 0.571120921592271 1 GO:0005543 phospholipid binding 74/2815 497/18639 0.148893360160966 0.985869747794047 0.573240510968576 1 GO:0004532 RNA exonuclease activity 6/2815 40/18639 0.15 0.993197158081705 0.574797541011805 1 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 6/2815 40/18639 0.15 0.993197158081705 0.574797541011805 1 GO:0031267 small GTPase binding 42/2815 283/18639 0.148409893992933 0.98266856629992 0.575076314358129 1 GO:0020037 heme binding 21/2815 142/18639 0.147887323943662 0.979208465714357 0.57787475798658 1 GO:0140463 chromatin-protein adaptor activity 8/2815 54/18639 0.148148148148148 0.980935464772054 0.581836013538248 1 GO:0003924 GTPase activity 49/2815 331/18639 0.148036253776435 0.980194576958782 0.584791534994867 1 GO:0015026 coreceptor activity 9/2815 61/18639 0.147540983606557 0.976915237457415 0.585182617546354 1 GO:0003777 microtubule motor activity 10/2815 68/18639 0.147058823529412 0.973722704001672 0.588418105887386 1 GO:0005548 phospholipid transporter activity 10/2815 68/18639 0.147058823529412 0.973722704001672 0.588418105887386 1 GO:0019003 GDP binding 11/2815 75/18639 0.146666666666667 0.971126110124334 0.591548789324988 1 GO:0019842 vitamin binding 22/2815 150/18639 0.146666666666667 0.971126110124334 0.594599768625892 1 GO:0001671 ATPase activator activity 4/2815 27/18639 0.148148148148148 0.980935464772054 0.598728904748297 1 GO:0016405 CoA-ligase activity 4/2815 27/18639 0.148148148148148 0.980935464772054 0.598728904748297 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/2815 27/18639 0.148148148148148 0.980935464772054 0.598728904748297 1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 5/2815 34/18639 0.147058823529412 0.973722704001672 0.599015326764821 1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 6/2815 41/18639 0.146341463414634 0.968972837152883 0.600166743153138 1 GO:0140828 metal cation:monoatomic cation antiporter activity 6/2815 41/18639 0.146341463414634 0.968972837152883 0.600166743153138 1 GO:0016004 phospholipase activator activity 3/2815 20/18639 0.15 0.993197158081705 0.600188866249713 1 GO:0140664 ATP-dependent DNA damage sensor activity 3/2815 20/18639 0.15 0.993197158081705 0.600188866249713 1 GO:0008035 high-density lipoprotein particle binding 2/2815 13/18639 0.153846153846154 1.01866375187867 0.605818095136538 1 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 2/2815 13/18639 0.153846153846154 1.01866375187867 0.605818095136538 1 GO:0031994 insulin-like growth factor I binding 2/2815 13/18639 0.153846153846154 1.01866375187867 0.605818095136538 1 GO:0035325 Toll-like receptor binding 2/2815 13/18639 0.153846153846154 1.01866375187867 0.605818095136538 1 GO:0035673 oligopeptide transmembrane transporter activity 2/2815 13/18639 0.153846153846154 1.01866375187867 0.605818095136538 1 GO:0039706 co-receptor binding 2/2815 13/18639 0.153846153846154 1.01866375187867 0.605818095136538 1 GO:0061459 L-arginine transmembrane transporter activity 2/2815 13/18639 0.153846153846154 1.01866375187867 0.605818095136538 1 GO:0089720 caspase binding 2/2815 13/18639 0.153846153846154 1.01866375187867 0.605818095136538 1 GO:0140666 annealing activity 2/2815 13/18639 0.153846153846154 1.01866375187867 0.605818095136538 1 GO:0140852 histone ubiquitin ligase activity 2/2815 13/18639 0.153846153846154 1.01866375187867 0.605818095136538 1 GO:0004222 metalloendopeptidase activity 16/2815 110/18639 0.145454545454545 0.963100274503472 0.605861079624939 1 GO:0046906 tetrapyrrole binding 22/2815 152/18639 0.144736842105263 0.958348134991119 0.620779100959646 1 GO:0005004 GPI-linked ephrin receptor activity 7/2815 49/18639 0.142857142857143 0.94590205531591 0.624505131954862 1 GO:0005008 hepatocyte growth factor receptor activity 7/2815 49/18639 0.142857142857143 0.94590205531591 0.624505131954862 1 GO:0005009 insulin receptor activity 7/2815 49/18639 0.142857142857143 0.94590205531591 0.624505131954862 1 GO:0005011 macrophage colony-stimulating factor receptor activity 7/2815 49/18639 0.142857142857143 0.94590205531591 0.624505131954862 1 GO:0005018 platelet-derived growth factor alpha-receptor activity 7/2815 49/18639 0.142857142857143 0.94590205531591 0.624505131954862 1 GO:0005020 stem cell factor receptor activity 7/2815 49/18639 0.142857142857143 0.94590205531591 0.624505131954862 1 GO:0008288 boss receptor activity 7/2815 49/18639 0.142857142857143 0.94590205531591 0.624505131954862 1 GO:0036332 placental growth factor receptor activity 7/2815 49/18639 0.142857142857143 0.94590205531591 0.624505131954862 1 GO:0038062 protein tyrosine kinase collagen receptor activity 7/2815 49/18639 0.142857142857143 0.94590205531591 0.624505131954862 1 GO:0060175 brain-derived neurotrophic factor receptor activity 7/2815 49/18639 0.142857142857143 0.94590205531591 0.624505131954862 1 GO:0019894 kinesin binding 6/2815 42/18639 0.142857142857143 0.94590205531591 0.62469555693985 1 GO:0005154 epidermal growth factor receptor binding 5/2815 35/18639 0.142857142857143 0.94590205531591 0.625854227436352 1 GO:0034061 DNA polymerase activity 5/2815 35/18639 0.142857142857143 0.94590205531591 0.625854227436352 1 GO:0043015 gamma-tubulin binding 5/2815 35/18639 0.142857142857143 0.94590205531591 0.625854227436352 1 GO:0046875 ephrin receptor binding 4/2815 28/18639 0.142857142857143 0.94590205531591 0.628658728239809 1 GO:0051393 alpha-actinin binding 4/2815 28/18639 0.142857142857143 0.94590205531591 0.628658728239809 1 GO:0070851 growth factor receptor binding 20/2815 139/18639 0.143884892086331 0.952707106073578 0.629507149376006 1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 3/2815 21/18639 0.142857142857143 0.94590205531591 0.634563506895488 1 GO:0005123 death receptor binding 3/2815 21/18639 0.142857142857143 0.94590205531591 0.634563506895488 1 GO:0005248 voltage-gated sodium channel activity 3/2815 21/18639 0.142857142857143 0.94590205531591 0.634563506895488 1 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/2815 21/18639 0.142857142857143 0.94590205531591 0.634563506895488 1 GO:0019200 carbohydrate kinase activity 3/2815 21/18639 0.142857142857143 0.94590205531591 0.634563506895488 1 GO:0051010 microtubule plus-end binding 3/2815 21/18639 0.142857142857143 0.94590205531591 0.634563506895488 1 GO:0070279 vitamin B6 binding 8/2815 57/18639 0.140350877192982 0.929307282415631 0.645538051227952 1 GO:0005006 epidermal growth factor receptor activity 7/2815 50/18639 0.14 0.926984014209592 0.646481927973864 1 GO:0005007 fibroblast growth factor receptor activity 7/2815 50/18639 0.14 0.926984014209592 0.646481927973864 1 GO:0005017 platelet-derived growth factor receptor activity 7/2815 50/18639 0.14 0.926984014209592 0.646481927973864 1 GO:0005019 platelet-derived growth factor beta-receptor activity 7/2815 50/18639 0.14 0.926984014209592 0.646481927973864 1 GO:0015605 organophosphate ester transmembrane transporter activity 7/2815 50/18639 0.14 0.926984014209592 0.646481927973864 1 GO:0004705 JUN kinase activity 2/2815 14/18639 0.142857142857143 0.94590205531591 0.647402800647492 1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/2815 14/18639 0.142857142857143 0.94590205531591 0.647402800647492 1 GO:0031404 chloride ion binding 2/2815 14/18639 0.142857142857143 0.94590205531591 0.647402800647492 1 GO:0032036 myosin heavy chain binding 2/2815 14/18639 0.142857142857143 0.94590205531591 0.647402800647492 1 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/2815 14/18639 0.142857142857143 0.94590205531591 0.647402800647492 1 GO:0042043 neurexin family protein binding 2/2815 14/18639 0.142857142857143 0.94590205531591 0.647402800647492 1 GO:0044548 S100 protein binding 2/2815 14/18639 0.142857142857143 0.94590205531591 0.647402800647492 1 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 2/2815 14/18639 0.142857142857143 0.94590205531591 0.647402800647492 1 GO:0061665 SUMO ligase activity 2/2815 14/18639 0.142857142857143 0.94590205531591 0.647402800647492 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2/2815 14/18639 0.142857142857143 0.94590205531591 0.647402800647492 1 GO:1901474 azole transmembrane transporter activity 2/2815 14/18639 0.142857142857143 0.94590205531591 0.647402800647492 1 GO:0005484 SNAP receptor activity 5/2815 36/18639 0.138888888888889 0.919626998223801 0.651579315870708 1 GO:0044390 ubiquitin-like protein conjugating enzyme binding 5/2815 36/18639 0.138888888888889 0.919626998223801 0.651579315870708 1 GO:0003785 actin monomer binding 4/2815 29/18639 0.137931034482759 0.913284743063637 0.65711706774364 1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 4/2815 29/18639 0.137931034482759 0.913284743063637 0.65711706774364 1 GO:0097472 cyclin-dependent protein kinase activity 4/2815 29/18639 0.137931034482759 0.913284743063637 0.65711706774364 1 GO:0120013 lipid transfer activity 9/2815 65/18639 0.138461538461538 0.916797376690805 0.664103722655661 1 GO:0008970 phospholipase A1 activity 3/2815 22/18639 0.136363636363636 0.902906507347005 0.66681819243181 1 GO:0031683 G-protein beta/gamma-subunit complex binding 3/2815 22/18639 0.136363636363636 0.902906507347005 0.66681819243181 1 GO:0005010 insulin-like growth factor receptor activity 7/2815 51/18639 0.137254901960784 0.908807857068227 0.667683115991696 1 GO:0005021 vascular endothelial growth factor receptor activity 7/2815 51/18639 0.137254901960784 0.908807857068227 0.667683115991696 1 GO:0005030 neurotrophin receptor activity 7/2815 51/18639 0.137254901960784 0.908807857068227 0.667683115991696 1 GO:0005048 signal sequence binding 7/2815 51/18639 0.137254901960784 0.908807857068227 0.667683115991696 1 GO:0016597 amino acid binding 7/2815 51/18639 0.137254901960784 0.908807857068227 0.667683115991696 1 GO:0043014 alpha-tubulin binding 6/2815 44/18639 0.136363636363636 0.902906507347005 0.671041133267352 1 GO:0008237 metallopeptidase activity 26/2815 184/18639 0.141304347826087 0.935620511236389 0.675406258585754 1 GO:0008081 phosphoric diester hydrolase activity 12/2815 87/18639 0.137931034482759 0.913284743063637 0.678943060456431 1 GO:0048019 receptor antagonist activity 4/2815 30/18639 0.133333333333333 0.882841918294849 0.684064502681039 1 GO:0098918 structural constituent of synapse 4/2815 30/18639 0.133333333333333 0.882841918294849 0.684064502681039 1 GO:0070888 E-box binding 8/2815 59/18639 0.135593220338983 0.89780534063883 0.684748879802346 1 GO:0004467 long-chain fatty acid-CoA ligase activity 2/2815 15/18639 0.133333333333333 0.882841918294849 0.68542251397552 1 GO:0004559 alpha-mannosidase activity 2/2815 15/18639 0.133333333333333 0.882841918294849 0.68542251397552 1 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/2815 15/18639 0.133333333333333 0.882841918294849 0.68542251397552 1 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/2815 15/18639 0.133333333333333 0.882841918294849 0.68542251397552 1 GO:0015929 hexosaminidase activity 2/2815 15/18639 0.133333333333333 0.882841918294849 0.68542251397552 1 GO:0031005 filamin binding 2/2815 15/18639 0.133333333333333 0.882841918294849 0.68542251397552 1 GO:0045504 dynein heavy chain binding 2/2815 15/18639 0.133333333333333 0.882841918294849 0.68542251397552 1 GO:0048531 beta-1,3-galactosyltransferase activity 2/2815 15/18639 0.133333333333333 0.882841918294849 0.68542251397552 1 GO:0051371 muscle alpha-actinin binding 2/2815 15/18639 0.133333333333333 0.882841918294849 0.68542251397552 1 GO:0004620 phospholipase activity 15/2815 109/18639 0.137614678899083 0.911190053285968 0.692623022711787 1 GO:0005525 GTP binding 54/2815 378/18639 0.142857142857143 0.94590205531591 0.694541414511911 1 GO:0030971 receptor tyrosine kinase binding 11/2815 81/18639 0.135802469135802 0.899190842707717 0.695835083006308 1 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 3/2815 23/18639 0.130434782608696 0.863649702679744 0.696939255728352 1 GO:0031681 G-protein beta-subunit binding 3/2815 23/18639 0.130434782608696 0.863649702679744 0.696939255728352 1 GO:0042171 lysophosphatidic acid acyltransferase activity 3/2815 23/18639 0.130434782608696 0.863649702679744 0.696939255728352 1 GO:0071617 lysophospholipid acyltransferase activity 3/2815 23/18639 0.130434782608696 0.863649702679744 0.696939255728352 1 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 3/2815 23/18639 0.130434782608696 0.863649702679744 0.696939255728352 1 GO:0019887 protein kinase regulator activity 36/2815 255/18639 0.141176470588235 0.934773795841605 0.697004418138076 1 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 8/2815 60/18639 0.133333333333333 0.882841918294849 0.703300911037155 1 GO:0005003 ephrin receptor activity 7/2815 53/18639 0.132075471698113 0.874513220952445 0.70765660794431 1 GO:0005005 transmembrane-ephrin receptor activity 7/2815 53/18639 0.132075471698113 0.874513220952445 0.70765660794431 1 GO:0038064 collagen receptor activity 7/2815 53/18639 0.132075471698113 0.874513220952445 0.70765660794431 1 GO:0051018 protein kinase A binding 7/2815 53/18639 0.132075471698113 0.874513220952445 0.70765660794431 1 GO:0016411 acylglycerol O-acyltransferase activity 4/2815 31/18639 0.129032258064516 0.854363146736951 0.709483241352354 1 GO:0003725 double-stranded RNA binding 10/2815 75/18639 0.133333333333333 0.882841918294849 0.713952615742626 1 GO:0005096 GTPase activator activity 38/2815 271/18639 0.140221402214022 0.928449987874657 0.716673453114037 1 GO:0003774 cytoskeletal motor activity 21/2815 153/18639 0.137254901960784 0.908807857068227 0.716932302303299 1 GO:1990841 promoter-specific chromatin binding 9/2815 68/18639 0.132352941176471 0.876350433601504 0.717084596519208 1 GO:0030295 protein kinase activator activity 19/2815 139/18639 0.136690647482014 0.905071750769899 0.717192697485816 1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2/2815 16/18639 0.125 0.827664298401421 0.720005177326349 1 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/2815 16/18639 0.125 0.827664298401421 0.720005177326349 1 GO:0004707 MAP kinase activity 2/2815 16/18639 0.125 0.827664298401421 0.720005177326349 1 GO:0015385 sodium:proton antiporter activity 2/2815 16/18639 0.125 0.827664298401421 0.720005177326349 1 GO:0015923 mannosidase activity 2/2815 16/18639 0.125 0.827664298401421 0.720005177326349 1 GO:0016722 oxidoreductase activity, acting on metal ions 2/2815 16/18639 0.125 0.827664298401421 0.720005177326349 1 GO:0019841 retinol binding 2/2815 16/18639 0.125 0.827664298401421 0.720005177326349 1 GO:0055102 lipase inhibitor activity 2/2815 16/18639 0.125 0.827664298401421 0.720005177326349 1 GO:0097027 ubiquitin-protein transferase activator activity 2/2815 16/18639 0.125 0.827664298401421 0.720005177326349 1 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 2/2815 16/18639 0.125 0.827664298401421 0.720005177326349 1 GO:0140328 floppase activity 2/2815 16/18639 0.125 0.827664298401421 0.720005177326349 1 GO:0019210 kinase inhibitor activity 12/2815 90/18639 0.133333333333333 0.882841918294849 0.724284848144155 1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/2815 24/18639 0.125 0.827664298401421 0.724945797821653 1 GO:0060229 lipase activator activity 3/2815 24/18639 0.125 0.827664298401421 0.724945797821653 1 GO:0070840 dynein complex binding 3/2815 24/18639 0.125 0.827664298401421 0.724945797821653 1 GO:0140612 DNA damage sensor activity 3/2815 24/18639 0.125 0.827664298401421 0.724945797821653 1 GO:0005506 iron ion binding 21/2815 154/18639 0.136363636363636 0.902906507347005 0.728103762591141 1 GO:0046982 protein heterodimerization activity 52/2815 369/18639 0.140921409214092 0.933084954295369 0.729333449088149 1 GO:0019207 kinase regulator activity 40/2815 287/18639 0.139372822299652 0.922831273478936 0.734832039960686 1 GO:0051087 protein-folding chaperone binding 18/2815 134/18639 0.134328358208955 0.889430290819437 0.741149221884439 1 GO:0004860 protein kinase inhibitor activity 11/2815 84/18639 0.130952380952381 0.867076884039584 0.741326836459087 1 GO:0061791 GTPase motor activity 5/2815 40/18639 0.125 0.827664298401421 0.742712768992822 1 GO:1990606 membrane scission GTPase motor activity 5/2815 40/18639 0.125 0.827664298401421 0.742712768992822 1 GO:0008013 beta-catenin binding 14/2815 106/18639 0.132075471698113 0.874513220952445 0.747064209349411 1 GO:0061134 peptidase regulator activity 31/2815 226/18639 0.13716814159292 0.90823338939625 0.747694004603983 1 GO:0015645 fatty acid ligase activity 3/2815 25/18639 0.12 0.794557726465364 0.750883085035802 1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/2815 25/18639 0.12 0.794557726465364 0.750883085035802 1 GO:0047617 fatty acyl-CoA hydrolase activity 3/2815 25/18639 0.12 0.794557726465364 0.750883085035802 1 GO:0120515 fatty acid-CoA ligase activity 3/2815 25/18639 0.12 0.794557726465364 0.750883085035802 1 GO:0005092 GDP-dissociation inhibitor activity 2/2815 17/18639 0.117647058823529 0.778978163201337 0.751321401068409 1 GO:0016805 dipeptidase activity 2/2815 17/18639 0.117647058823529 0.778978163201337 0.751321401068409 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/2815 17/18639 0.117647058823529 0.778978163201337 0.751321401068409 1 GO:0016879 ligase activity, forming carbon-nitrogen bonds 6/2815 48/18639 0.125 0.827664298401421 0.752138551021199 1 GO:0038187 pattern recognition receptor activity 6/2815 48/18639 0.125 0.827664298401421 0.752138551021199 1 GO:0140693 molecular condensate scaffold activity 6/2815 48/18639 0.125 0.827664298401421 0.752138551021199 1 GO:0019001 guanyl nucleotide binding 56/2815 400/18639 0.14 0.926984014209592 0.753321185624575 1 GO:0032561 guanyl ribonucleotide binding 56/2815 400/18639 0.14 0.926984014209592 0.753321185624575 1 GO:0019239 deaminase activity 4/2815 33/18639 0.121212121212121 0.802583562086226 0.755753900119654 1 GO:0030170 pyridoxal phosphate binding 7/2815 56/18639 0.125 0.827664298401421 0.761344871018901 1 GO:0004812 aminoacyl-tRNA ligase activity 5/2815 41/18639 0.121951219512195 0.807477364294069 0.762510828137223 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 5/2815 41/18639 0.121951219512195 0.807477364294069 0.762510828137223 1 GO:0005539 glycosaminoglycan binding 33/2815 242/18639 0.136363636363636 0.902906507347005 0.76484382031985 1 GO:0035254 glutamate receptor binding 6/2815 49/18639 0.122448979591837 0.81077319027078 0.769947865309526 1 GO:0019903 protein phosphatase binding 19/2815 144/18639 0.131944444444444 0.873645648312611 0.772570516864253 1 GO:0033293 monocarboxylic acid binding 10/2815 79/18639 0.126582278481013 0.838141061672325 0.773412417810704 1 GO:0004112 cyclic-nucleotide phosphodiesterase activity 3/2815 26/18639 0.115384615384615 0.763997813909004 0.77481674253051 1 GO:0008157 protein phosphatase 1 binding 3/2815 26/18639 0.115384615384615 0.763997813909004 0.77481674253051 1 GO:0016289 acyl-CoA hydrolase activity 3/2815 26/18639 0.115384615384615 0.763997813909004 0.77481674253051 1 GO:0030247 polysaccharide binding 3/2815 26/18639 0.115384615384615 0.763997813909004 0.77481674253051 1 GO:0030507 spectrin binding 3/2815 26/18639 0.115384615384615 0.763997813909004 0.77481674253051 1 GO:0043548 phosphatidylinositol 3-kinase binding 3/2815 26/18639 0.115384615384615 0.763997813909004 0.77481674253051 1 GO:0052866 phosphatidylinositol phosphate phosphatase activity 4/2815 34/18639 0.117647058823529 0.778978163201337 0.776652376566965 1 GO:0090482 vitamin transmembrane transporter activity 4/2815 34/18639 0.117647058823529 0.778978163201337 0.776652376566965 1 GO:0000400 four-way junction DNA binding 2/2815 18/18639 0.111111111111111 0.735701598579041 0.779568665994807 1 GO:0004970 glutamate-gated receptor activity 2/2815 18/18639 0.111111111111111 0.735701598579041 0.779568665994807 1 GO:0008409 5'-3' exonuclease activity 2/2815 18/18639 0.111111111111111 0.735701598579041 0.779568665994807 1 GO:0022851 GABA-gated chloride ion channel activity 2/2815 18/18639 0.111111111111111 0.735701598579041 0.779568665994807 1 GO:0031690 adrenergic receptor binding 2/2815 18/18639 0.111111111111111 0.735701598579041 0.779568665994807 1 GO:0008307 structural constituent of muscle 5/2815 42/18639 0.119047619047619 0.788251712763258 0.781134513434165 1 GO:0042056 chemoattractant activity 5/2815 42/18639 0.119047619047619 0.788251712763258 0.781134513434165 1 GO:0048306 calcium-dependent protein binding 10/2815 80/18639 0.125 0.827664298401421 0.786808877913565 1 GO:0005104 fibroblast growth factor receptor binding 3/2815 27/18639 0.111111111111111 0.735701598579041 0.796827722253287 1 GO:0008266 poly(U) RNA binding 3/2815 27/18639 0.111111111111111 0.735701598579041 0.796827722253287 1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 3/2815 27/18639 0.111111111111111 0.735701598579041 0.796827722253287 1 GO:0035255 ionotropic glutamate receptor binding 3/2815 27/18639 0.111111111111111 0.735701598579041 0.796827722253287 1 GO:0008235 metalloexopeptidase activity 8/2815 66/18639 0.121212121212121 0.802583562086226 0.799273677619279 1 GO:0004890 GABA-A receptor activity 2/2815 19/18639 0.105263157894737 0.696980461811723 0.804959321551995 1 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/2815 19/18639 0.105263157894737 0.696980461811723 0.804959321551995 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/2815 19/18639 0.105263157894737 0.696980461811723 0.804959321551995 1 GO:0016918 retinal binding 2/2815 19/18639 0.105263157894737 0.696980461811723 0.804959321551995 1 GO:0043395 heparan sulfate proteoglycan binding 2/2815 19/18639 0.105263157894737 0.696980461811723 0.804959321551995 1 GO:0046624 sphingolipid transporter activity 2/2815 19/18639 0.105263157894737 0.696980461811723 0.804959321551995 1 GO:0004382 GDP phosphatase activity 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0004935 adrenergic receptor activity 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0005381 iron ion transmembrane transporter activity 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0008140 cAMP response element binding protein binding 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0008190 eukaryotic initiation factor 4E binding 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0015279 store-operated calcium channel activity 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0019911 structural constituent of myelin sheath 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0031419 cobalamin binding 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0031434 mitogen-activated protein kinase kinase binding 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0032052 bile acid binding 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0042975 peroxisome proliferator activated receptor binding 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0043121 neurotrophin binding 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0043208 glycosphingolipid binding 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0043422 protein kinase B binding 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0051880 G-quadruplex DNA binding 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0070097 delta-catenin binding 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0070513 death domain binding 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0070739 protein-glutamic acid ligase activity 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0070740 tubulin-glutamic acid ligase activity 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0099122 RNA polymerase II C-terminal domain binding 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0140135 mechanosensitive monoatomic cation channel activity 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0140999 histone H3K4 trimethyltransferase activity 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:1990757 ubiquitin ligase activator activity 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:1990763 arrestin family protein binding 1/2815 10/18639 0.1 0.662131438721137 0.805575914234707 1 GO:0019209 kinase activator activity 19/2815 148/18639 0.128378378378378 0.850033603763621 0.811271155050282 1 GO:0016500 protein-hormone receptor activity 8/2815 67/18639 0.119402985074627 0.790604702950611 0.812727029424844 1 GO:0004190 aspartic-type endopeptidase activity 4/2815 36/18639 0.111111111111111 0.735701598579041 0.814176563060054 1 GO:0030547 signaling receptor inhibitor activity 5/2815 44/18639 0.113636363636364 0.752422089455837 0.814963110781011 1 GO:0051019 mitogen-activated protein kinase binding 3/2815 28/18639 0.107142857142857 0.709426541486932 0.817008001534904 1 GO:0005319 lipid transporter activity 23/2815 178/18639 0.129213483146067 0.85556309497675 0.820873469754169 1 GO:0004714 transmembrane receptor protein tyrosine kinase activity 7/2815 60/18639 0.116666666666667 0.772486678507993 0.821266818405085 1 GO:0015297 antiporter activity 17/2815 135/18639 0.125925925925926 0.833795145056246 0.825221714208707 1 GO:0005326 neurotransmitter transmembrane transporter activity 2/2815 20/18639 0.1 0.662131438721137 0.827711594363359 1 GO:0010851 cyclase regulator activity 2/2815 20/18639 0.1 0.662131438721137 0.827711594363359 1 GO:0030627 pre-mRNA 5'-splice site binding 2/2815 20/18639 0.1 0.662131438721137 0.827711594363359 1 GO:0042288 MHC class I protein binding 2/2815 20/18639 0.1 0.662131438721137 0.827711594363359 1 GO:0140303 intramembrane lipid transporter activity 5/2815 45/18639 0.111111111111111 0.735701598579041 0.830234745730279 1 GO:0043394 proteoglycan binding 4/2815 37/18639 0.108108108108108 0.715817771590418 0.830907235223482 1 GO:0070001 aspartic-type peptidase activity 4/2815 37/18639 0.108108108108108 0.715817771590418 0.830907235223482 1 GO:1901505 carbohydrate derivative transmembrane transporter activity 6/2815 53/18639 0.113207547169811 0.749582760816381 0.83164645042189 1 GO:0030246 carbohydrate binding 37/2815 280/18639 0.132142857142857 0.874959401167216 0.834653846772204 1 GO:0008234 cysteine-type peptidase activity 24/2815 187/18639 0.128342245989305 0.849794359856004 0.834668240112661 1 GO:0000099 sulfur amino acid transmembrane transporter activity 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0003953 NAD+ nucleosidase activity 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0008432 JUN kinase binding 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0008503 benzodiazepine receptor activity 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0015173 aromatic amino acid transmembrane transporter activity 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0015217 ADP transmembrane transporter activity 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0016594 glycine binding 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0034056 estrogen response element binding 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0034713 type I transforming growth factor beta receptor binding 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0035252 UDP-xylosyltransferase activity 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0042285 xylosyltransferase activity 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0042608 T cell receptor binding 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0047676 arachidonate-CoA ligase activity 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0050786 RAGE receptor binding 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0070697 activin receptor binding 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0140031 phosphorylation-dependent protein binding 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0140537 transcription regulator activator activity 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/2815 11/18639 0.0909090909090909 0.60193767156467 0.834955043625941 1 GO:0004181 metallocarboxypeptidase activity 3/2815 29/18639 0.103448275862069 0.684963557297728 0.835456955433896 1 GO:0043236 laminin binding 3/2815 29/18639 0.103448275862069 0.684963557297728 0.835456955433896 1 GO:0099604 ligand-gated calcium channel activity 3/2815 29/18639 0.103448275862069 0.684963557297728 0.835456955433896 1 GO:0035591 signaling adaptor activity 16/2815 129/18639 0.124031007751938 0.821248296088232 0.837120605747735 1 GO:0019888 protein phosphatase regulator activity 13/2815 107/18639 0.121495327102804 0.804458757324746 0.839326161895649 1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 15/2815 122/18639 0.122950819672131 0.814096031214512 0.84053919064397 1 GO:0001221 transcription coregulator binding 14/2815 115/18639 0.121739130434783 0.806073055834427 0.844344764191606 1 GO:0017124 SH3 domain binding 14/2815 115/18639 0.121739130434783 0.806073055834427 0.844344764191606 1 GO:0004180 carboxypeptidase activity 5/2815 46/18639 0.108695652173913 0.719708085566453 0.844463223408321 1 GO:0030291 protein serine/threonine kinase inhibitor activity 5/2815 46/18639 0.108695652173913 0.719708085566453 0.844463223408321 1 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 6/2815 54/18639 0.111111111111111 0.735701598579041 0.844802776048495 1 GO:0016298 lipase activity 16/2815 130/18639 0.123076923076923 0.814931001502938 0.845704000473309 1 GO:0000146 microfilament motor activity 4/2815 38/18639 0.105263157894737 0.696980461811723 0.846362846626604 1 GO:0042887 amide transmembrane transporter activity 4/2815 38/18639 0.105263157894737 0.696980461811723 0.846362846626604 1 GO:0043531 ADP binding 4/2815 38/18639 0.105263157894737 0.696980461811723 0.846362846626604 1 GO:0008194 UDP-glycosyltransferase activity 18/2815 145/18639 0.124137931034483 0.821956268757273 0.847720207780228 1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/2815 21/18639 0.0952380952380952 0.630601370210606 0.848042971991556 1 GO:0009975 cyclase activity 2/2815 21/18639 0.0952380952380952 0.630601370210606 0.848042971991556 1 GO:0015125 bile acid transmembrane transporter activity 2/2815 21/18639 0.0952380952380952 0.630601370210606 0.848042971991556 1 GO:0015174 basic amino acid transmembrane transporter activity 2/2815 21/18639 0.0952380952380952 0.630601370210606 0.848042971991556 1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/2815 21/18639 0.0952380952380952 0.630601370210606 0.848042971991556 1 GO:0001965 G-protein alpha-subunit binding 3/2815 30/18639 0.1 0.662131438721137 0.852278339073102 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 3/2815 30/18639 0.1 0.662131438721137 0.852278339073102 1 GO:0008187 poly-pyrimidine tract binding 3/2815 30/18639 0.1 0.662131438721137 0.852278339073102 1 GO:0016769 transferase activity, transferring nitrogenous groups 3/2815 30/18639 0.1 0.662131438721137 0.852278339073102 1 GO:0070566 adenylyltransferase activity 3/2815 30/18639 0.1 0.662131438721137 0.852278339073102 1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 10/2815 86/18639 0.116279069767442 0.769920277582717 0.855218391781343 1 GO:1901682 sulfur compound transmembrane transporter activity 7/2815 63/18639 0.111111111111111 0.735701598579041 0.857953216002317 1 GO:0140767 enzyme-substrate adaptor activity 17/2815 139/18639 0.122302158273381 0.809801040162541 0.858510892097074 1 GO:0005025 transforming growth factor beta receptor activity, type I 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0005026 transforming growth factor beta receptor activity, type II 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0005078 MAP-kinase scaffold activity 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0008179 adenylate cyclase binding 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0010853 cyclase activator activity 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0015132 prostaglandin transmembrane transporter activity 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0015368 calcium:monoatomic cation antiporter activity 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0016361 activin receptor activity, type I 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0016362 activin receptor activity, type II 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0017002 activin receptor activity 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0017166 vinculin binding 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0035197 siRNA binding 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0070008 serine-type exopeptidase activity 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0140900 chloride:bicarbonate antiporter activity 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:1990817 poly(A) RNA polymerase activity 1/2815 12/18639 0.0833333333333333 0.551776198934281 0.859896076060608 1 GO:0060589 nucleoside-triphosphatase regulator activity 66/2815 490/18639 0.13469387755102 0.891850509297858 0.862192340856779 1 GO:0004407 histone deacetylase activity 2/2815 22/18639 0.0909090909090909 0.60193767156467 0.866165449947531 1 GO:0008093 cytoskeletal anchor activity 2/2815 22/18639 0.0909090909090909 0.60193767156467 0.866165449947531 1 GO:0016881 acid-amino acid ligase activity 2/2815 22/18639 0.0909090909090909 0.60193767156467 0.866165449947531 1 GO:0033558 protein lysine deacetylase activity 2/2815 22/18639 0.0909090909090909 0.60193767156467 0.866165449947531 1 GO:0070034 telomerase RNA binding 2/2815 22/18639 0.0909090909090909 0.60193767156467 0.866165449947531 1 GO:0005164 tumor necrosis factor receptor binding 3/2815 31/18639 0.0967741935483871 0.640772360052713 0.867577813828896 1 GO:0005184 neuropeptide hormone activity 3/2815 31/18639 0.0967741935483871 0.640772360052713 0.867577813828896 1 GO:0072349 modified amino acid transmembrane transporter activity 3/2815 31/18639 0.0967741935483871 0.640772360052713 0.867577813828896 1 GO:0170055 lipid transmembrane transporter activity 6/2815 56/18639 0.107142857142857 0.709426541486932 0.868602022497907 1 GO:0015932 nucleobase-containing compound transmembrane transporter activity 6/2815 57/18639 0.105263157894737 0.696980461811723 0.879313104463587 1 GO:0004535 poly(A)-specific ribonuclease activity 1/2815 13/18639 0.0769230769230769 0.509331875939336 0.881069241137614 1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/2815 13/18639 0.0769230769230769 0.509331875939336 0.881069241137614 1 GO:0005172 vascular endothelial growth factor receptor binding 1/2815 13/18639 0.0769230769230769 0.509331875939336 0.881069241137614 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/2815 13/18639 0.0769230769230769 0.509331875939336 0.881069241137614 1 GO:0030955 potassium ion binding 1/2815 13/18639 0.0769230769230769 0.509331875939336 0.881069241137614 1 GO:0031432 titin binding 1/2815 13/18639 0.0769230769230769 0.509331875939336 0.881069241137614 1 GO:0045159 myosin II binding 1/2815 13/18639 0.0769230769230769 0.509331875939336 0.881069241137614 1 GO:0046974 histone H3K9 methyltransferase activity 1/2815 13/18639 0.0769230769230769 0.509331875939336 0.881069241137614 1 GO:0051011 microtubule minus-end binding 1/2815 13/18639 0.0769230769230769 0.509331875939336 0.881069241137614 1 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/2815 13/18639 0.0769230769230769 0.509331875939336 0.881069241137614 1 GO:0070123 transforming growth factor beta receptor activity, type III 1/2815 13/18639 0.0769230769230769 0.509331875939336 0.881069241137614 1 GO:0071714 icosanoid transmembrane transporter activity 1/2815 13/18639 0.0769230769230769 0.509331875939336 0.881069241137614 1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/2815 13/18639 0.0769230769230769 0.509331875939336 0.881069241137614 1 GO:0140333 glycerophospholipid flippase activity 1/2815 13/18639 0.0769230769230769 0.509331875939336 0.881069241137614 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/2815 13/18639 0.0769230769230769 0.509331875939336 0.881069241137614 1 GO:0060590 ATPase regulator activity 5/2815 49/18639 0.102040816326531 0.67564432522565 0.88133083724757 1 GO:0160041 neuropeptide activity 3/2815 32/18639 0.09375 0.620748223801066 0.881460951968441 1 GO:0003727 single-stranded RNA binding 10/2815 89/18639 0.112359550561798 0.743967908675435 0.882227788048014 1 GO:0000295 adenine nucleotide transmembrane transporter activity 2/2815 23/18639 0.0869565217391304 0.575766468453162 0.882282230349357 1 GO:0016917 GABA receptor activity 2/2815 23/18639 0.0869565217391304 0.575766468453162 0.882282230349357 1 GO:0017134 fibroblast growth factor binding 2/2815 23/18639 0.0869565217391304 0.575766468453162 0.882282230349357 1 GO:0030695 GTPase regulator activity 65/2815 489/18639 0.132924335378323 0.880133814251 0.885660221941578 1 GO:0008227 G protein-coupled amine receptor activity 4/2815 41/18639 0.0975609756097561 0.645981891435255 0.885727939184014 1 GO:0042169 SH2 domain binding 4/2815 41/18639 0.0975609756097561 0.645981891435255 0.885727939184014 1 GO:0032813 tumor necrosis factor receptor superfamily binding 5/2815 50/18639 0.1 0.662131438721137 0.891836026998226 1 GO:0019956 chemokine binding 3/2815 33/18639 0.0909090909090909 0.60193767156467 0.894031657153319 1 GO:0030296 protein tyrosine kinase activator activity 3/2815 33/18639 0.0909090909090909 0.60193767156467 0.894031657153319 1 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/2815 24/18639 0.0833333333333333 0.551776198934281 0.89658554239733 1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/2815 24/18639 0.0833333333333333 0.551776198934281 0.89658554239733 1 GO:0019957 C-C chemokine binding 2/2815 24/18639 0.0833333333333333 0.551776198934281 0.89658554239733 1 GO:0030215 semaphorin receptor binding 2/2815 24/18639 0.0833333333333333 0.551776198934281 0.89658554239733 1 GO:0050431 transforming growth factor beta binding 2/2815 24/18639 0.0833333333333333 0.551776198934281 0.89658554239733 1 GO:0035198 miRNA binding 4/2815 42/18639 0.0952380952380952 0.630601370210606 0.896737773473471 1 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 7/2815 67/18639 0.104477611940299 0.691779115081785 0.897070394283508 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 10/2815 91/18639 0.10989010989011 0.727616965627623 0.897837340170022 1 GO:0036002 pre-mRNA binding 6/2815 59/18639 0.101694915254237 0.673354005479122 0.898536797494306 1 GO:0004065 arylsulfatase activity 1/2815 14/18639 0.0714285714285714 0.472951027657955 0.899043582713777 1 GO:0005161 platelet-derived growth factor receptor binding 1/2815 14/18639 0.0714285714285714 0.472951027657955 0.899043582713777 1 GO:0005313 L-glutamate transmembrane transporter activity 1/2815 14/18639 0.0714285714285714 0.472951027657955 0.899043582713777 1 GO:0005347 ATP transmembrane transporter activity 1/2815 14/18639 0.0714285714285714 0.472951027657955 0.899043582713777 1 GO:0005545 1-phosphatidylinositol binding 1/2815 14/18639 0.0714285714285714 0.472951027657955 0.899043582713777 1 GO:0008191 metalloendopeptidase inhibitor activity 1/2815 14/18639 0.0714285714285714 0.472951027657955 0.899043582713777 1 GO:0019992 diacylglycerol binding 1/2815 14/18639 0.0714285714285714 0.472951027657955 0.899043582713777 1 GO:0034236 protein kinase A catalytic subunit binding 1/2815 14/18639 0.0714285714285714 0.472951027657955 0.899043582713777 1 GO:0098821 BMP receptor activity 1/2815 14/18639 0.0714285714285714 0.472951027657955 0.899043582713777 1 GO:1990825 sequence-specific mRNA binding 1/2815 14/18639 0.0714285714285714 0.472951027657955 0.899043582713777 1 GO:0001217 DNA-binding transcription repressor activity 35/2815 278/18639 0.12589928057554 0.833618717814381 0.899081584412166 1 GO:0030544 Hsp70 protein binding 5/2815 51/18639 0.0980392156862745 0.649148469334448 0.901528609864882 1 GO:0035401 histone H3Y41 kinase activity 13/2815 115/18639 0.11304347826087 0.748496408989111 0.902305665672301 1 GO:0140801 histone H2AXY142 kinase activity 13/2815 115/18639 0.11304347826087 0.748496408989111 0.902305665672301 1 GO:0017022 myosin binding 8/2815 76/18639 0.105263157894737 0.696980461811723 0.904498804401561 1 GO:0008376 acetylgalactosaminyltransferase activity 3/2815 34/18639 0.0882352941176471 0.584233622401003 0.905390942371353 1 GO:0051427 hormone receptor binding 3/2815 34/18639 0.0882352941176471 0.584233622401003 0.905390942371353 1 GO:0004712 protein serine/threonine/tyrosine kinase activity 4/2815 43/18639 0.0930232558139535 0.615936222066174 0.90680233069034 1 GO:0005537 D-mannose binding 2/2815 25/18639 0.08 0.52970515097691 0.909255321298333 1 GO:0008483 transaminase activity 2/2815 25/18639 0.08 0.52970515097691 0.909255321298333 1 GO:0015662 P-type ion transporter activity 2/2815 25/18639 0.08 0.52970515097691 0.909255321298333 1 GO:0140358 P-type transmembrane transporter activity 2/2815 25/18639 0.08 0.52970515097691 0.909255321298333 1 GO:0000774 adenyl-nucleotide exchange factor activity 1/2815 15/18639 0.0666666666666667 0.441420959147424 0.914302230480796 1 GO:0004089 carbonate dehydratase activity 1/2815 15/18639 0.0666666666666667 0.441420959147424 0.914302230480796 1 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/2815 15/18639 0.0666666666666667 0.441420959147424 0.914302230480796 1 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/2815 15/18639 0.0666666666666667 0.441420959147424 0.914302230480796 1 GO:0017081 chloride channel regulator activity 1/2815 15/18639 0.0666666666666667 0.441420959147424 0.914302230480796 1 GO:0030553 cGMP binding 1/2815 15/18639 0.0666666666666667 0.441420959147424 0.914302230480796 1 GO:0033130 acetylcholine receptor binding 1/2815 15/18639 0.0666666666666667 0.441420959147424 0.914302230480796 1 GO:0034483 heparan sulfate sulfotransferase activity 1/2815 15/18639 0.0666666666666667 0.441420959147424 0.914302230480796 1 GO:0047372 monoacylglycerol lipase activity 1/2815 15/18639 0.0666666666666667 0.441420959147424 0.914302230480796 1 GO:0050780 dopamine receptor binding 1/2815 15/18639 0.0666666666666667 0.441420959147424 0.914302230480796 1 GO:0061578 K63-linked deubiquitinase activity 1/2815 15/18639 0.0666666666666667 0.441420959147424 0.914302230480796 1 GO:0140161 monocarboxylate:sodium symporter activity 1/2815 15/18639 0.0666666666666667 0.441420959147424 0.914302230480796 1 GO:0140776 protein-containing complex destabilizing activity 1/2815 15/18639 0.0666666666666667 0.441420959147424 0.914302230480796 1 GO:0141050 histone H3K deacetylase activity 1/2815 15/18639 0.0666666666666667 0.441420959147424 0.914302230480796 1 GO:0141051 histone H4K deacetylase activity 1/2815 15/18639 0.0666666666666667 0.441420959147424 0.914302230480796 1 GO:0019208 phosphatase regulator activity 13/2815 117/18639 0.111111111111111 0.735701598579041 0.914392264937573 1 GO:1990782 protein tyrosine kinase binding 13/2815 117/18639 0.111111111111111 0.735701598579041 0.914392264937573 1 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 33/2815 268/18639 0.123134328358209 0.815311099917818 0.917733181114015 1 GO:0004864 protein phosphatase inhibitor activity 5/2815 53/18639 0.0943396226415094 0.624652300680318 0.918665478214095 1 GO:0005246 calcium channel regulator activity 5/2815 53/18639 0.0943396226415094 0.624652300680318 0.918665478214095 1 GO:0005544 calcium-dependent phospholipid binding 5/2815 53/18639 0.0943396226415094 0.624652300680318 0.918665478214095 1 GO:0017046 peptide hormone binding 5/2815 53/18639 0.0943396226415094 0.624652300680318 0.918665478214095 1 GO:0019199 transmembrane receptor protein kinase activity 8/2815 78/18639 0.102564102564103 0.679109167919115 0.918677710852434 1 GO:0097110 scaffold protein binding 7/2815 70/18639 0.1 0.662131438721137 0.920043527807527 1 GO:0001637 G protein-coupled chemoattractant receptor activity 2/2815 26/18639 0.0769230769230769 0.509331875939336 0.920458536195651 1 GO:0004950 chemokine receptor activity 2/2815 26/18639 0.0769230769230769 0.509331875939336 0.920458536195651 1 GO:0005112 Notch binding 2/2815 26/18639 0.0769230769230769 0.509331875939336 0.920458536195651 1 GO:0005227 calcium-activated cation channel activity 2/2815 26/18639 0.0769230769230769 0.509331875939336 0.920458536195651 1 GO:0008066 glutamate receptor activity 2/2815 26/18639 0.0769230769230769 0.509331875939336 0.920458536195651 1 GO:0015216 purine nucleotide transmembrane transporter activity 2/2815 26/18639 0.0769230769230769 0.509331875939336 0.920458536195651 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/2815 36/18639 0.0833333333333333 0.551776198934281 0.924859598001824 1 GO:0045505 dynein intermediate chain binding 3/2815 36/18639 0.0833333333333333 0.551776198934281 0.924859598001824 1 GO:0003925 G protein activity 5/2815 54/18639 0.0925925925925926 0.613084665482534 0.926202488639156 1 GO:0004708 MAP kinase kinase activity 1/2815 16/18639 0.0625 0.41383214920071 0.927255367357759 1 GO:0005024 transforming growth factor beta receptor activity 1/2815 16/18639 0.0625 0.41383214920071 0.927255367357759 1 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/2815 16/18639 0.0625 0.41383214920071 0.927255367357759 1 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/2815 16/18639 0.0625 0.41383214920071 0.927255367357759 1 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/2815 16/18639 0.0625 0.41383214920071 0.927255367357759 1 GO:0140327 flippase activity 1/2815 16/18639 0.0625 0.41383214920071 0.927255367357759 1 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/2815 27/18639 0.0740740740740741 0.490467732386027 0.93034900131104 1 GO:0031490 chromatin DNA binding 14/2815 128/18639 0.109375 0.724206261101243 0.930868971860601 1 GO:0030276 clathrin binding 4/2815 46/18639 0.0869565217391304 0.575766468453162 0.93196073240238 1 GO:0019955 cytokine binding 16/2815 144/18639 0.111111111111111 0.735701598579041 0.932720709036901 1 GO:0004175 endopeptidase activity 51/2815 405/18639 0.125925925925926 0.833795145056246 0.935507168779246 1 GO:0008484 sulfuric ester hydrolase activity 1/2815 17/18639 0.0588235294117647 0.389489081600669 0.938251240250843 1 GO:0008569 minus-end-directed microtubule motor activity 1/2815 17/18639 0.0588235294117647 0.389489081600669 0.938251240250843 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/2815 17/18639 0.0588235294117647 0.389489081600669 0.938251240250843 1 GO:0030548 acetylcholine receptor regulator activity 1/2815 17/18639 0.0588235294117647 0.389489081600669 0.938251240250843 1 GO:0031489 myosin V binding 1/2815 17/18639 0.0588235294117647 0.389489081600669 0.938251240250843 1 GO:0038191 neuropilin binding 1/2815 17/18639 0.0588235294117647 0.389489081600669 0.938251240250843 1 GO:1990226 histone methyltransferase binding 1/2815 17/18639 0.0588235294117647 0.389489081600669 0.938251240250843 1 GO:0140359 ABC-type transporter activity 4/2815 47/18639 0.0851063829787234 0.563516118060542 0.938869487444947 1 GO:0051959 dynein light intermediate chain binding 2/2815 28/18639 0.0714285714285714 0.472951027657955 0.939067539755359 1 GO:0000149 SNARE binding 11/2815 106/18639 0.10377358490566 0.687117530748349 0.939132557860338 1 GO:0019212 phosphatase inhibitor activity 5/2815 56/18639 0.0892857142857143 0.591188784572444 0.939436199070227 1 GO:0042626 ATPase-coupled transmembrane transporter activity 10/2815 98/18639 0.102040816326531 0.67564432522565 0.9395331650759 1 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 14/2815 130/18639 0.107692307692308 0.71306462631507 0.939625882008878 1 GO:0005501 retinoid binding 3/2815 38/18639 0.0789473684210526 0.522735346358792 0.940588369427878 1 GO:0019840 isoprenoid binding 3/2815 38/18639 0.0789473684210526 0.522735346358792 0.940588369427878 1 GO:0004629 phospholipase C activity 2/2815 29/18639 0.0689655172413793 0.456642371531818 0.946742397853245 1 GO:0106222 lncRNA binding 2/2815 29/18639 0.0689655172413793 0.456642371531818 0.946742397853245 1 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/2815 18/18639 0.0555555555555556 0.36785079928952 0.947585509324727 1 GO:0015172 acidic amino acid transmembrane transporter activity 1/2815 18/18639 0.0555555555555556 0.36785079928952 0.947585509324727 1 GO:0017075 syntaxin-1 binding 1/2815 18/18639 0.0555555555555556 0.36785079928952 0.947585509324727 1 GO:0050811 GABA receptor binding 1/2815 18/18639 0.0555555555555556 0.36785079928952 0.947585509324727 1 GO:0099602 neurotransmitter receptor regulator activity 1/2815 18/18639 0.0555555555555556 0.36785079928952 0.947585509324727 1 GO:0001222 transcription corepressor binding 4/2815 49/18639 0.0816326530612245 0.54051546018052 0.950804859824839 1 GO:0042277 peptide binding 29/2815 249/18639 0.116465863453815 0.771157097305742 0.951605268473589 1 GO:0032451 demethylase activity 3/2815 40/18639 0.075 0.496598579040853 0.953216699274764 1 GO:0071855 neuropeptide receptor binding 3/2815 40/18639 0.075 0.496598579040853 0.953216699274764 1 GO:0071949 FAD binding 3/2815 40/18639 0.075 0.496598579040853 0.953216699274764 1 GO:0015215 nucleotide transmembrane transporter activity 2/2815 30/18639 0.0666666666666667 0.441420959147424 0.953489830623255 1 GO:0022839 monoatomic ion-gated channel activity 2/2815 30/18639 0.0666666666666667 0.441420959147424 0.953489830623255 1 GO:0031624 ubiquitin conjugating enzyme binding 2/2815 30/18639 0.0666666666666667 0.441420959147424 0.953489830623255 1 GO:0001786 phosphatidylserine binding 5/2815 59/18639 0.0847457627118644 0.561128337899268 0.955305330965154 1 GO:0022840 leak channel activity 1/2815 19/18639 0.0526315789473684 0.348490230905861 0.955509186423213 1 GO:0022842 narrow pore channel activity 1/2815 19/18639 0.0526315789473684 0.348490230905861 0.955509186423213 1 GO:0030506 ankyrin binding 1/2815 19/18639 0.0526315789473684 0.348490230905861 0.955509186423213 1 GO:0031420 alkali metal ion binding 1/2815 19/18639 0.0526315789473684 0.348490230905861 0.955509186423213 1 GO:0034987 immunoglobulin receptor binding 1/2815 19/18639 0.0526315789473684 0.348490230905861 0.955509186423213 1 GO:0042562 hormone binding 9/2815 94/18639 0.0957446808510638 0.63395563281811 0.957132071709891 1 GO:0019783 ubiquitin-like protein peptidase activity 13/2815 127/18639 0.102362204724409 0.677772338848408 0.957608387574694 1 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/2815 41/18639 0.0731707317073171 0.484486418576442 0.958544759281928 1 GO:0005452 solute:inorganic anion antiporter activity 2/2815 31/18639 0.0645161290322581 0.427181573368475 0.959414797298728 1 GO:0005272 sodium channel activity 4/2815 51/18639 0.0784313725490196 0.519318775467558 0.960562709912378 1 GO:0099106 ion channel regulator activity 17/2815 160/18639 0.10625 0.703514653641208 0.960591686332844 1 GO:0005085 guanyl-nucleotide exchange factor activity 26/2815 230/18639 0.11304347826087 0.748496408989111 0.960709595575198 1 GO:0016247 channel regulator activity 18/2815 168/18639 0.107142857142857 0.709426541486932 0.960864158223275 1 GO:0061135 endopeptidase regulator activity 20/2815 184/18639 0.108695652173913 0.719708085566453 0.961629184115388 1 GO:0016408 C-acyltransferase activity 1/2815 20/18639 0.05 0.331065719360568 0.962235375478994 1 GO:0030742 GTP-dependent protein binding 1/2815 20/18639 0.05 0.331065719360568 0.962235375478994 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 6/2815 70/18639 0.0857142857142857 0.567541233189546 0.963675590503722 1 GO:0004896 cytokine receptor activity 9/2815 96/18639 0.09375 0.620748223801066 0.963829215809249 1 GO:0015106 bicarbonate transmembrane transporter activity 2/2815 32/18639 0.0625 0.41383214920071 0.964611720320747 1 GO:0005080 protein kinase C binding 4/2815 52/18639 0.0769230769230769 0.509331875939336 0.964738257740948 1 GO:0141108 transporter regulator activity 18/2815 170/18639 0.105882352941176 0.701080346881204 0.96572088718183 1 GO:0005245 voltage-gated calcium channel activity 3/2815 43/18639 0.0697674418604651 0.46195216654963 0.967536403714305 1 GO:0001846 opsonin binding 1/2815 21/18639 0.0476190476190476 0.315300685105303 0.967944995653366 1 GO:0051428 peptide hormone receptor binding 1/2815 21/18639 0.0476190476190476 0.315300685105303 0.967944995653366 1 GO:0061891 calcium ion sensor activity 1/2815 21/18639 0.0476190476190476 0.315300685105303 0.967944995653366 1 GO:0101005 deubiquitinase activity 11/2815 115/18639 0.0956521739130435 0.633343115298479 0.969882564164431 1 GO:0004713 protein tyrosine kinase activity 14/2815 140/18639 0.1 0.662131438721137 0.970484887655674 1 GO:0005243 gap junction channel activity 1/2815 22/18639 0.0454545454545455 0.300968835782335 0.972791640686978 1 GO:0015377 chloride:monoatomic cation symporter activity 1/2815 22/18639 0.0454545454545455 0.300968835782335 0.972791640686978 1 GO:0033691 sialic acid binding 1/2815 22/18639 0.0454545454545455 0.300968835782335 0.972791640686978 1 GO:0050321 tau-protein kinase activity 1/2815 22/18639 0.0454545454545455 0.300968835782335 0.972791640686978 1 GO:0140784 metal ion sensor activity 1/2815 22/18639 0.0454545454545455 0.300968835782335 0.972791640686978 1 GO:0015020 glucuronosyltransferase activity 2/2815 34/18639 0.0588235294117647 0.389489081600669 0.9731511684339 1 GO:0030332 cyclin binding 2/2815 34/18639 0.0588235294117647 0.389489081600669 0.9731511684339 1 GO:0004715 non-membrane spanning protein tyrosine kinase activity 3/2815 45/18639 0.0666666666666667 0.441420959147424 0.9746623740297 1 GO:0008009 chemokine activity 3/2815 45/18639 0.0666666666666667 0.441420959147424 0.9746623740297 1 GO:0030165 PDZ domain binding 7/2815 83/18639 0.0843373493975904 0.558424104945537 0.975640505192953 1 GO:0005343 organic acid:sodium symporter activity 2/2815 35/18639 0.0571428571428571 0.378360822126364 0.976636935505246 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/2815 23/18639 0.0434782608695652 0.287883234226581 0.976905704793233 1 GO:0005283 amino acid:sodium symporter activity 1/2815 23/18639 0.0434782608695652 0.287883234226581 0.976905704793233 1 GO:0016493 C-C chemokine receptor activity 1/2815 23/18639 0.0434782608695652 0.287883234226581 0.976905704793233 1 GO:0016849 phosphorus-oxygen lyase activity 1/2815 23/18639 0.0434782608695652 0.287883234226581 0.976905704793233 1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/2815 23/18639 0.0434782608695652 0.287883234226581 0.976905704793233 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 4/2815 56/18639 0.0714285714285714 0.472951027657955 0.977653760131004 1 GO:0051015 actin filament binding 22/2815 209/18639 0.105263157894737 0.696980461811723 0.978836457142832 1 GO:1902936 phosphatidylinositol bisphosphate binding 10/2815 111/18639 0.0900900900900901 0.596514809658682 0.979316968366432 1 GO:0004806 triacylglycerol lipase activity 1/2815 24/18639 0.0416666666666667 0.27588809946714 0.980397885766968 1 GO:0005315 phosphate transmembrane transporter activity 1/2815 24/18639 0.0416666666666667 0.27588809946714 0.980397885766968 1 GO:0015149 hexose transmembrane transporter activity 1/2815 24/18639 0.0416666666666667 0.27588809946714 0.980397885766968 1 GO:0015295 solute:proton symporter activity 1/2815 24/18639 0.0416666666666667 0.27588809946714 0.980397885766968 1 GO:0050699 WW domain binding 1/2815 24/18639 0.0416666666666667 0.27588809946714 0.980397885766968 1 GO:0055056 D-glucose transmembrane transporter activity 1/2815 24/18639 0.0416666666666667 0.27588809946714 0.980397885766968 1 GO:0005253 monoatomic anion channel activity 9/2815 103/18639 0.087378640776699 0.578561451309731 0.980486804205634 1 GO:0008083 growth factor activity 16/2815 162/18639 0.0987654320987654 0.653956976514703 0.980621939866211 1 GO:0005200 structural constituent of cytoskeleton 10/2815 112/18639 0.0892857142857143 0.591188784572444 0.981045846026126 1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 26/2815 243/18639 0.106995884773663 0.708453391224262 0.981894385099632 1 GO:0061980 regulatory RNA binding 4/2815 58/18639 0.0689655172413793 0.456642371531818 0.982294935148334 1 GO:0030280 structural constituent of skin epidermis 2/2815 37/18639 0.0540540540540541 0.357908885795209 0.982341698319377 1 GO:0001848 complement binding 1/2815 25/18639 0.04 0.264852575488455 0.983362159286494 1 GO:0005251 delayed rectifier potassium channel activity 1/2815 25/18639 0.04 0.264852575488455 0.983362159286494 1 GO:0008139 nuclear localization sequence binding 1/2815 25/18639 0.04 0.264852575488455 0.983362159286494 1 GO:0015271 outward rectifier potassium channel activity 1/2815 25/18639 0.04 0.264852575488455 0.983362159286494 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/2815 25/18639 0.04 0.264852575488455 0.983362159286494 1 GO:0031072 heat shock protein binding 12/2815 131/18639 0.0916030534351145 0.606532615622415 0.983859112814644 1 GO:0106310 protein serine kinase activity 41/2815 361/18639 0.113573407202216 0.752005235112648 0.984020050879271 1 GO:0004676 3-phosphoinositide-dependent protein kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:0004711 ribosomal protein S6 kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:0035175 histone H3S10 kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:0035979 histone H2AXS139 kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:0044022 histone H3S28 kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:0044023 histone H4S1 kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:0044024 histone H2AS1 kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:0044025 histone H2BS14 kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:0072354 histone H3T3 kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:0072371 histone H2AS121 kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:0072518 Rho-dependent protein serine/threonine kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:0140823 histone H2BS36 kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:0140855 histone H3S57 kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:0140995 histone H2A kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:0140997 histone H4 kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:0140998 histone H2B kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:1990244 histone H2AT120 kinase activity 26/2815 245/18639 0.106122448979592 0.702670098234676 0.98402712172533 1 GO:0004677 DNA-dependent protein kinase activity 26/2815 246/18639 0.105691056910569 0.699813715721527 0.985006239134475 1 GO:0140857 histone H3T45 kinase activity 26/2815 246/18639 0.105691056910569 0.699813715721527 0.985006239134475 1 GO:0004857 enzyme inhibitor activity 48/2815 416/18639 0.115384615384615 0.763997813909004 0.985526912432608 1 GO:0005160 transforming growth factor beta receptor binding 1/2815 26/18639 0.0384615384615385 0.254665937969668 0.985878304210128 1 GO:0015145 monosaccharide transmembrane transporter activity 1/2815 26/18639 0.0384615384615385 0.254665937969668 0.985878304210128 1 GO:0035402 histone H3T11 kinase activity 26/2815 247/18639 0.105263157894737 0.696980461811723 0.98593085422409 1 GO:0035403 histone H3T6 kinase activity 26/2815 247/18639 0.105263157894737 0.696980461811723 0.98593085422409 1 GO:0016782 transferase activity, transferring sulphur-containing groups 5/2815 70/18639 0.0714285714285714 0.472951027657955 0.986264409822377 1 GO:0004679 AMP-activated protein kinase activity 26/2815 248/18639 0.104838709677419 0.694170056723773 0.986803592665765 1 GO:0019905 syntaxin binding 4/2815 61/18639 0.0655737704918033 0.434184549981073 0.987580976662735 1 GO:0004843 cysteine-type deubiquitinase activity 9/2815 108/18639 0.0833333333333333 0.551776198934281 0.987691198388351 1 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/2815 27/18639 0.037037037037037 0.245233866193014 0.988014046629324 1 GO:0023026 MHC class II protein complex binding 1/2815 27/18639 0.037037037037037 0.245233866193014 0.988014046629324 1 GO:0001664 G protein-coupled receptor binding 32/2815 297/18639 0.107744107744108 0.713407610743312 0.988192320107263 1 GO:0003779 actin binding 51/2815 443/18639 0.115124153498871 0.762273213877607 0.988354606274358 1 GO:0015179 L-amino acid transmembrane transporter activity 4/2815 62/18639 0.0645161290322581 0.427181573368475 0.98898056033471 1 GO:0042379 chemokine receptor binding 5/2815 72/18639 0.0694444444444444 0.459813499111901 0.98902282969602 1 GO:0005242 inward rectifier potassium channel activity 1/2815 28/18639 0.0357142857142857 0.236475513828977 0.989826880217249 1 GO:0050698 proteoglycan sulfotransferase activity 1/2815 28/18639 0.0357142857142857 0.236475513828977 0.989826880217249 1 GO:0051119 sugar transmembrane transporter activity 1/2815 28/18639 0.0357142857142857 0.236475513828977 0.989826880217249 1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/2815 28/18639 0.0357142857142857 0.236475513828977 0.989826880217249 1 GO:0141052 histone H3 demethylase activity 1/2815 28/18639 0.0357142857142857 0.236475513828977 0.989826880217249 1 GO:0017080 sodium channel regulator activity 2/2815 41/18639 0.0487804878048781 0.322990945717628 0.989978113272075 1 GO:0042287 MHC protein binding 2/2815 41/18639 0.0487804878048781 0.322990945717628 0.989978113272075 1 GO:0022824 transmitter-gated monoatomic ion channel activity 4/2815 63/18639 0.0634920634920635 0.420400913473738 0.990228761219791 1 GO:0022835 transmitter-gated channel activity 4/2815 63/18639 0.0634920634920635 0.420400913473738 0.990228761219791 1 GO:0008514 organic anion transmembrane transporter activity 28/2815 269/18639 0.104089219330855 0.68920744550899 0.990508775091253 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 3/2815 53/18639 0.0566037735849057 0.374791380408191 0.990864266940233 1 GO:0005416 amino acid:monoatomic cation symporter activity 1/2815 29/18639 0.0344827586206897 0.228321185765909 0.991365611730249 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 17/2815 181/18639 0.0939226519337017 0.621891406533664 0.991419139803247 1 GO:0005516 calmodulin binding 20/2815 207/18639 0.0966183574879227 0.639740520503514 0.992100584755375 1 GO:0032452 histone demethylase activity 1/2815 30/18639 0.0333333333333333 0.220710479573712 0.992671673147731 1 GO:0004867 serine-type endopeptidase inhibitor activity 7/2815 95/18639 0.0736842105263158 0.487886323268206 0.992730590878795 1 GO:0004252 serine-type endopeptidase activity 16/2815 176/18639 0.0909090909090909 0.60193767156467 0.993462121502162 1 GO:0141003 histone H2AX kinase activity 38/2815 354/18639 0.107344632768362 0.710762561339073 0.99353408476788 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/2815 31/18639 0.032258064516129 0.213590786684238 0.993780235676031 1 GO:0140457 protein demethylase activity 1/2815 31/18639 0.032258064516129 0.213590786684238 0.993780235676031 1 GO:0004497 monooxygenase activity 8/2815 106/18639 0.0754716981132075 0.499721840544254 0.993847641931561 1 GO:0140996 histone H3 kinase activity 38/2815 357/18639 0.106442577030812 0.704789766705972 0.994594544265692 1 GO:0042910 xenobiotic transmembrane transporter activity 1/2815 32/18639 0.03125 0.206916074600355 0.994721155526202 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/2815 46/18639 0.0434782608695652 0.287883234226581 0.995114551751518 1 GO:0098960 postsynaptic neurotransmitter receptor activity 4/2815 69/18639 0.0579710144927536 0.383844312302108 0.995309924983292 1 GO:0035173 histone kinase activity 38/2815 360/18639 0.105555555555556 0.698916518650089 0.995492822121253 1 GO:0099095 ligand-gated monoatomic anion channel activity 2/2815 47/18639 0.0425531914893617 0.281758059030271 0.995773638113059 1 GO:0015101 organic cation transmembrane transporter activity 5/2815 81/18639 0.0617283950617284 0.408723110321689 0.996118019281632 1 GO:0005126 cytokine receptor binding 27/2815 275/18639 0.0981818181818182 0.650092685289843 0.996312721089428 1 GO:0015171 amino acid transmembrane transporter activity 7/2815 102/18639 0.0686274509803922 0.454403928534113 0.996551383490953 1 GO:0008528 G protein-coupled peptide receptor activity 9/2815 122/18639 0.0737704918032787 0.488457618728707 0.996864073324131 1 GO:0005254 chloride channel activity 5/2815 83/18639 0.0602409638554217 0.398874360675384 0.996937679485115 1 GO:0008236 serine-type peptidase activity 17/2815 194/18639 0.0876288659793814 0.580218271044295 0.996989495474887 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 53/2815 484/18639 0.109504132231405 0.725061286202898 0.997007211160912 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 4/2815 73/18639 0.0547945205479452 0.362811747244458 0.997156217244097 1 GO:0048020 CCR chemokine receptor binding 2/2815 50/18639 0.04 0.264852575488455 0.99726970098096 1 GO:0023023 MHC protein complex binding 1/2815 37/18639 0.027027027027027 0.178954442897605 0.997675652043607 1 GO:0030551 cyclic nucleotide binding 1/2815 37/18639 0.027027027027027 0.178954442897605 0.997675652043607 1 GO:0017171 serine hydrolase activity 17/2815 198/18639 0.0858585858585859 0.568496689811077 0.997849641282527 1 GO:0001216 DNA-binding transcription activator activity 53/2815 491/18639 0.107942973523422 0.714724363589007 0.997981731068304 1 GO:0030594 neurotransmitter receptor activity 6/2815 97/18639 0.0618556701030928 0.409565838384208 0.998019817432081 1 GO:0008146 sulfotransferase activity 2/2815 53/18639 0.0377358490566038 0.249860920272127 0.998241464682895 1 GO:0001653 peptide receptor activity 9/2815 128/18639 0.0703125 0.465561167850799 0.998307575177762 1 GO:0015144 carbohydrate transmembrane transporter activity 1/2815 40/18639 0.025 0.165532859680284 0.998579279786792 1 GO:0008509 monoatomic anion transmembrane transporter activity 11/2815 149/18639 0.0738255033557047 0.488821867512249 0.998631644615744 1 GO:0005262 calcium channel activity 9/2815 131/18639 0.0687022900763359 0.454899461716812 0.998764351506355 1 GO:0030414 peptidase inhibitor activity 13/2815 169/18639 0.0769230769230769 0.509331875939336 0.998817746562366 1 GO:0005179 hormone activity 9/2815 132/18639 0.0681818181818182 0.451453253673502 0.998888327480826 1 GO:0046943 carboxylic acid transmembrane transporter activity 15/2815 188/18639 0.0797872340425532 0.528296360681758 0.998907934176521 1 GO:0051879 Hsp90 protein binding 1/2815 42/18639 0.0238095238095238 0.157650342552652 0.998976802782691 1 GO:0001618 virus receptor activity 4/2815 81/18639 0.0493827160493827 0.326978488257351 0.998977993268294 1 GO:0005342 organic acid transmembrane transporter activity 15/2815 189/18639 0.0793650793650794 0.525501141842172 0.999003484095751 1 GO:0140272 exogenous protein binding 4/2815 82/18639 0.0487804878048781 0.322990945717628 0.999102443047 1 GO:0015085 calcium ion transmembrane transporter activity 10/2815 147/18639 0.0680272108843537 0.450429550150433 0.999364909250064 1 GO:0004674 protein serine/threonine kinase activity 43/2815 433/18639 0.0993071593533487 0.65754392297942 0.999456103612218 1 GO:0015108 chloride transmembrane transporter activity 7/2815 121/18639 0.0578512396694215 0.383051245541154 0.999595935137144 1 GO:0004866 endopeptidase inhibitor activity 11/2815 161/18639 0.0683229813664596 0.452387939498913 0.999596115700659 1 GO:0140375 immune receptor activity 10/2815 156/18639 0.0641025641025641 0.424443229949447 0.999757089624355 1 GO:0015291 secondary active transmembrane transporter activity 24/2815 287/18639 0.0836236933797909 0.553698764087362 0.999797093454203 1 GO:0003730 mRNA 3'-UTR binding 21/2815 262/18639 0.0801526717557252 0.530716038669613 0.999822597592787 1 GO:0015079 potassium ion transmembrane transporter activity 10/2815 160/18639 0.0625 0.41383214920071 0.99984301273263 1 GO:0015103 inorganic anion transmembrane transporter activity 10/2815 165/18639 0.0606060606060606 0.401291781043113 0.999909718812383 1 GO:0005267 potassium channel activity 6/2815 124/18639 0.0483870967741935 0.320386180026356 0.999924590862608 1 GO:0015294 solute:monoatomic cation symporter activity 5/2815 116/18639 0.0431034482758621 0.285401482207387 0.99995203897179 1 GO:0005261 monoatomic cation channel activity 28/2815 341/18639 0.0821114369501466 0.543685638832605 0.999959172655572 1 GO:0015370 solute:sodium symporter activity 2/2815 79/18639 0.0253164556962025 0.167628212334465 0.999964564758993 1 GO:0005216 monoatomic ion channel activity 40/2815 448/18639 0.0892857142857143 0.591188784572444 0.999969037003221 1 GO:0015081 sodium ion transmembrane transporter activity 9/2815 164/18639 0.0548780487804878 0.363364813932331 0.999969071567363 1 GO:0015276 ligand-gated monoatomic ion channel activity 11/2815 186/18639 0.0591397849462366 0.391583108921102 0.999973008647605 1 GO:0022834 ligand-gated channel activity 11/2815 188/18639 0.0585106382978723 0.387417331166623 0.999978441579634 1 GO:0005249 voltage-gated potassium channel activity 3/2815 98/18639 0.0306122448979592 0.202693297567695 0.99998245418462 1 GO:0099094 ligand-gated monoatomic cation channel activity 6/2815 136/18639 0.0441176470588235 0.292116811200502 0.999983683494429 1 GO:0005244 voltage-gated monoatomic ion channel activity 9/2815 173/18639 0.0520231213872832 0.344461442109262 0.999989349302782 1 GO:0022832 voltage-gated channel activity 9/2815 175/18639 0.0514285714285714 0.340524739913727 0.999991620658163 1 GO:0015293 symporter activity 6/2815 146/18639 0.0410958904109589 0.272108810433344 0.999995573176879 1 GO:0005125 cytokine activity 14/2815 234/18639 0.0598290598290598 0.396147014619484 0.999996102652982 1 GO:0022843 voltage-gated monoatomic cation channel activity 5/2815 143/18639 0.034965034965035 0.231514489063335 0.999998743203339 1 GO:0046873 metal ion transmembrane transporter activity 33/2815 450/18639 0.0733333333333333 0.485563055062167 0.999999869979757 1 GO:0022836 gated channel activity 19/2815 318/18639 0.059748427672956 0.395613123764201 0.999999899174847 1 GO:0003823 antigen binding 3/2815 174/18639 0.0172413793103448 0.114160592882955 0.999999999809522 1 GO:0045182 translation regulator activity 13/2815 356/18639 0.0365168539325843 0.241789570319516 0.999999999999702 1 GO:0030371 translation repressor activity 7/2815 329/18639 0.0212765957446809 0.140879029515135 1 1