category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	83/722	238/9376	4.52878325845574	F13A1/C1QA/C1QC/C1QB/RPL27A/CYBB/FCGR2A/RPLP1/RPS23/RPS11/RPL23/UBA52/RPL21/RPL13A/RPL23A/RPL14/RPS2/RPL28/RPL15/CCL2/RPS12/RPL27/RPL38/RPL19/RPS24/RPS14/RPLP2/CXCL8/RPL41/RPS7/RPS18/MMP1/RPL35/CFD/C3AR1/RPS4X/RPL26/RPS15/C2/RPL39/RPS20/RPL18/SYK/RPS16/RPL30/RPL24/RPS19/RPL9/RPL10/RPL10A/RPS27A/RPL37/RPL37A/RPL17/RPL18A/C1R/RPL12/RPS25/FAU/RPL7A/RPL6/RPL7/RPL11/RPS13/RPL13/RPL31/PRKCB/RPL32/RPL22/RPL29/RPS3A/TLR2/NLRP3/RPLP0/RPL36A/RPS15A/RPL8/RPS3/TLR4/RPL5/TLR7/RPS10/NRP1	15.9269889070912
Genetic Information Processing	Translation	hsa03010	Ribosome	72/722	222/9376	4.21172418956353	RPL27A/RPLP1/RPS23/RPS11/RPL23/UBA52/RPL21/RPL13A/RPL23A/RPL14/RPS2/RPL28/RPL15/RPS12/RPL27/RPL38/RPL19/RPS24/RPS14/RPLP2/RPL41/RPS7/RPS18/RPL35/RPS4X/RPL26/RPS15/RPL39/RPS20/RPL18/RPS16/RPL30/RPL24/RPS19/RPL9/RPL10/RPL10A/RPS27A/RPL37/RPL37A/RPL17/RPL18A/RPL12/RPS25/FAU/RPL7A/RPL6/RPL7/RPL11/RPS13/RPL13/RPL31/RPL32/RPL22/RPL29/RPS3A/RPLP0/RPL36A/RPS15A/MRPS11/RPL8/RPS3/RPL5/RPS10/MRPL37/MRPL47/MRPL33/RACK1/MRPS18A/MRPL11/MRPL42/MRPS18B	13.987982084818
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	55/722	275/9376	2.59722991689751	C1QA/C1QC/MT-ATP6/CYBA/C1QB/MT-CO2/CYBB/MT-CYB/MT-CO3/MT-ND5/MT-ND1/MT-ND3/NCF4/MT-ND2/MT-CO1/TUBA1B/ATP5F1E/UQCRB/ITPR2/UQCR10/NCF2/COX4I1/PSMB2/RYR1/UQCRC2/RYR2/ATP5MC1/PSMB3/GRIN2C/COX6C/NDUFA4L2/COX4I2/ADRM1/PSMD4/NDUFB9/PSMB5/GRIN2B/ATP5MC3/PSMC1/NDUFC2/PSMC2/COX7A2L/NDUFB1/PSMC5/NDUFA5/UQCR11/PSMD3/NCAM2/NDUFS7/PSMC4/COX7C/NDUFS3/SOD1/SEM1/NDUFA9	7.76488480932103
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	52/722	268/9376	2.51970066564684	MT-ATP6/MT-CO2/MT-CYB/MT-CO3/MT-ND5/MT-ND1/UBA52/MT-ND3/MT-ND2/MT-CO1/TUBA1B/ATP5F1E/UQCRB/ITPR2/RPS27A/UQCR10/CALM1/UBB/COX4I1/PSMB2/UQCRC2/ATP5MC1/PSMB3/COX6C/NDUFA4L2/COX4I2/ADRM1/PSMD4/SLC39A1/CALM2/NDUFB9/PSMB5/ATP5MC3/PSMC1/NDUFC2/PSMC2/COX7A2L/NDUFB1/PSMC5/NDUFA5/TRAP1/UQCR11/PSMD3/UBE2L3/NDUFS7/PSMC4/COX7C/UBA7/NDUFS3/SOD1/SEM1/NDUFA9	7.29054057416614
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	43/722	205/9376	2.72392405918519	CD36/MT-ATP6/CYBA/MT-CO2/COL3A1/SLC2A1/CYBB/MT-CYB/MT-CO3/MT-ND5/MT-ND1/COL1A1/MT-ND3/NCF4/MT-ND2/MT-CO1/ATP5F1E/UQCRB/UQCR10/COL1A2/NCF2/COX4I1/PRKCB/CTSD/UQCRC2/RYR2/ATP5MC1/COX6C/NDUFA4L2/PPP1CC/COX4I2/NDUFB9/ATP5MC3/NDUFC2/COX7A2L/NDUFB1/NDUFA5/UQCR11/NDUFS7/COX7C/NDUFS3/NDUFA9/G6PD	7.20829424039856
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	32/722	138/9376	3.01128106306957	MT-ATP6/MT-CO2/MT-CYB/MT-CO3/MT-ND5/MT-ND1/MT-ND3/MT-ND2/MT-CO1/ATP5F1E/UQCRB/UQCR10/ATP5MF/COX4I1/UQCRC2/ATP5MC1/COX6C/NDUFA4L2/COX4I2/NDUFB9/ATP5MC3/NDUFC2/ATP6AP1/ATP5MG/COX7A2L/NDUFB1/NDUFA5/UQCR11/NDUFS7/COX7C/NDUFS3/NDUFA9	6.87494329432475
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	49/722	308/9376	2.06597834298665	MT-ATP6/MT-CO2/MT-CYB/MT-CO3/MT-ND5/MT-ND1/DNAH8/MT-ND3/MT-ND2/MT-CO1/TUBA1B/ATP5F1E/UQCRB/UQCR10/GPX7/COX4I1/PSMB2/CLTA/UQCRC2/ATP5MC1/PSMB3/COX6C/NDUFA4L2/COX4I2/ADRM1/PSMD4/NDUFB9/PSMB5/GRIN2B/DCTN3/ATP5MC3/PSMC1/NDUFC2/POLR2F/PSMC2/COX7A2L/NDUFB1/PSMC5/NDUFA5/UQCR11/PSMD3/NDUFS7/PSMC4/GRIA4/COX7C/NDUFS3/SOD1/SEM1/NDUFA9	5.49431779238593
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	67/722	480/9376	1.81265004616805	MT-ATP6/MT-CO2/CYBB/MT-CYB/MT-CO3/MT-ND5/WNT2/MT-ND1/UBA52/DNAH8/MT-ND3/MT-ND2/MT-CO1/TUBA1B/ATP5F1E/UQCRB/ITPR2/RPS27A/UQCR10/CALM1/UBB/GPX7/COX4I1/PRKCB/PSMB2/LRP6/RYR1/UQCRC2/RYR2/ATP5MC1/PSMB3/GRIN2C/COX6C/NDUFA4L2/CHRM3/COX4I2/ADRM1/PSMD4/CALM2/NDUFB9/PSMB5/GRIN2B/DCTN3/ATP5MC3/PSMC1/NDUFC2/PSMC2/COX7A2L/NDUFB1/PSMC5/FZD2/NDUFA5/TRAP1/UQCR11/PSMD3/UBE2L3/NDUFS7/VAPB/PSMC4/GRIA4/HRAS/COX7C/UBA7/NDUFS3/SOD1/SEM1/NDUFA9	5.2792543626877
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	55/722	368/9376	1.94086474768156	MT-ATP6/MT-CO2/MT-CYB/MT-CO3/ACTB/MT-ND5/MT-ND1/DNAH8/MT-ND3/MT-ND2/MT-CO1/TUBA1B/ATP5F1E/UQCRB/UQCR10/PFN1/GPX7/COX4I1/CHCHD10/PSMB2/UQCRC2/ATP5MC1/PSMB3/GRIN2C/COX6C/NDUFA4L2/COX4I2/ADRM1/PSMD4/NDUFB9/PSMB5/GRIN2B/DCTN3/ATP5MC3/PSMC1/NDUFC2/SEC13/PSMC2/UBQLN4/COX7A2L/NDUFB1/PSMC5/NUP214/NDUFA5/UQCR11/PSMD3/NDUFS7/VAPB/PSMC4/COX7C/NDUFS3/SOD1/SEM1/NDUFA9/NUP54	5.31842095381203
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	56/722	388/9376	1.87428963075078	MT-ATP6/MT-CO2/CYBB/APOE/MT-CYB/MT-CO3/MT-ND5/WNT2/MT-ND1/MT-ND3/MT-ND2/MT-CO1/TUBA1B/ATP5F1E/UQCRB/ITPR2/UQCR10/CALM1/LRP1/COX4I1/PSMB2/LRP6/UQCRC2/ATP5MC1/PSMB3/GRIN2C/COX6C/NDUFA4L2/CHRM3/COX4I2/ADRM1/PSMD4/SLC39A1/CALM2/NDUFB9/PSMB5/GRIN2B/ATP5MC3/PSMC1/NDUFC2/PSMC2/PSENEN/COX7A2L/NDUFB1/PSMC5/FZD2/NDUFA5/UQCR11/PSMD3/NDUFS7/PSMC4/HRAS/COX7C/NDUFS3/SEM1/NDUFA9	5.08025427620168
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	14/722	46/9376	3.95230639527882	PSMB2/PSME2/PSMB3/ADRM1/PSMD4/PSMB5/PSMC1/PSMF1/PSMC2/PSMC5/POMP/PSMD3/PSMC4/SEM1	5.79756081284963
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	38/722	235/9376	2.09988801791713	MT-ATP6/MT-CO2/MT-CYB/MT-CO3/ACTB/MT-ND5/MT-ND1/MT-ND3/MT-ND2/MT-CO1/ATP5F1E/UQCRB/UQCR10/ATP5MF/COX4I1/UQCRC2/ATP5MC1/PRDM16/COA4/COX20/COX6C/NDUFA4L2/COX4I2/NDUFB9/ATP5MC3/SIRT6/NDUFC2/ATP5MG/COX7A2L/NDUFB1/NDUFA5/COA3/UQCR11/NDUFS7/HRAS/COX7C/NDUFS3/NDUFA9	4.93209393154971
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	14/722	50/9376	3.63612188365651	HBA2/HBB/CD36/HBA1/HGF/CR1/CCL2/CXCL8/ITGB2/LRP1/GYPC/TLR2/TLR4/GYPB	5.3981950742258
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	28/722	155/9376	2.34588508623001	CD36/CD14/CYBA/FCGR2B/CYBB/FCGR3A/FCGR2A/MRC1/ACTB/COLEC12/NCF4/FCGR1A/TUBA1B/CLEC7A/SCARB1/ITGB2/C1R/MSR1/CORO1A/NCF2/CD209/ITGAM/TLR2/TLR4/RILP/CALR/CTSS/ATP6AP1	4.88012122609484
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	36/722	227/9376	2.0594774671434	MT-ATP6/CYBA/MT-CO2/MT-CYB/MT-CO3/HGF/MT-ND5/MT-ND1/MT-ND3/MT-ND2/MT-CO1/ATP5F1E/UQCRB/UQCR10/NCF2/COX4I1/UQCRC2/ATP5MC1/COX6C/NDUFA4L2/COX4I2/PTPRJ/NDUFB9/ATP5MC3/NDUFC2/COX7A2L/NDUFB1/GSTO1/NDUFA5/UQCR11/NDUFS7/HRAS/COX7C/NDUFS3/SOD1/NDUFA9	4.6672775825736
NA	NA	hsa04518	Integrin signaling	25/722	154/9376	2.10814116631291	SPP1/LAMA2/HGF/ACTB/COL1A1/IGF1/PDGFC/FREM1/ITGB2/COL1A2/CCND1/COL4A1/FRAS1/FERMT3/CCND2/ITGAM/VTN/COL6A2/COL4A2/ILK/COL6A1/LAMC3/NCK2/KDR/TLN1	4.00487238433285
NA	NA	hsa04517	IgSF CAM signaling	39/722	299/9376	1.69384559797664	ACTB/SLIT2/MTSS1/PTPRD/TUBA1B/GRIP2/CADM3/CD28/CD86/ITGB2/LCP2/ARPC3/ANK2/IL1RAPL1/PRKCB/DOK2/CD209/CD84/ITGAM/LRFN5/ROBO2/VAV1/SCN8A/LYN/MYL6/LRRTM4/ARPC4/EPB41L1/EZR/NRP1/DYNLL2/ANK3/SLAMF1/NCK2/KDR/CLMP/NCAM2/ARPC1A/CDH2	3.52186784401399
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	15/722	78/9376	2.4973364585553	C1QA/CD14/C1QC/C1QB/CXCL8/C2/ITGB2/CALM1/C1R/C4BPB/ITGAM/NLRP3/TLR4/CALM2/PYCARD	3.83546232665135
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	30/722	212/9376	1.83766267705012	HGF/ACTB/ANGPT1/IGF1/CSF1R/PDGFC/P2RY1/FYB1/ITGB2/LCP2/CALM1/PFN1/SIPA1L2/PRKCB/ITGAM/VAV1/FPR1/FGFR3/CALM2/FGF7/GRIN2B/RASGRP2/LPAR5/KITLG/KDR/FGF10/APBB1IP/TLN1/HRAS/FARP2	3.56320121009935
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	17/722	98/9376	2.25269941771723	FCGR2B/FCGR3A/FCGR2A/PTPRC/FCGR1A/SYK/ARPC3/BIN1/MARCKS/PRKCB/HCK/VAV1/LYN/SCIN/WAS/ARPC4/ARPC1A	3.60063020900611
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	11/722	52/9376	2.74707010441082	CD36/PLTP/APOE/ABCA1/APOC1/SCARB1/LRP1/NPC2/MYLIP/LRPAP1/VAPB	3.64885548433955
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	23/722	157/9376	1.90242955696314	MT-CO2/MT-CYB/MT-CO3/MT-CO1/CXCL8/UQCRB/UQCR10/COX4I1/UQCRC2/COX6C/NDUFA4L2/COX4I2/NDUFB9/CEBPA/NDUFC2/COX7A2L/NDUFB1/NDUFA5/UQCR11/NDUFS7/COX7C/NDUFS3/NDUFA9	3.29357093485509
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	17/722	103/9376	2.14334507705134	COL3A1/COL15A1/SLC16A10/COL1A1/COL14A1/ATP1B1/COL11A1/COL1A2/COL4A1/KCNQ1/COL6A2/COL4A2/COL5A1/SLC7A7/COL6A1/COL8A2/KCNE3	3.37001318600746
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	15/722	87/9376	2.23899130767026	MT-CO2/MT-CYB/MT-CO3/ATP1B1/MT-CO1/UQCRB/UQCR10/COX4I1/UQCRC2/RYR2/COX6C/COX4I2/COX7A2L/UQCR11/COX7C	3.35342961939372
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	15/722	88/9376	2.21354822462856	F13A1/C1QA/C1QC/C1QB/CR1/VSIG4/CFD/C3AR1/C2/F3/ITGB2/C1R/C4BPB/ITGAM/VTN	3.30356657625442
Organismal Systems	Immune system	hsa04611	Platelet activation	19/722	126/9376	1.95822890559733	FCER1G/COL3A1/FCGR2A/VAMP8/ACTB/COL1A1/P2RY1/SYK/ITPR2/LCP2/TBXAS1/COL1A2/FERMT3/LYN/PPP1CC/GUCY1B1/RASGRP2/APBB1IP/TLN1	3.12773150895878
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	16/722	99/9376	2.09877165001819	C1QA/C1QC/C1QB/FCGR2B/FCGR3A/FCGR2A/FCGR1A/CFD/C3AR1/C2/ITGB2/C1R/ITGAM/FPR1/KRT18/KRT19	3.1744395109061
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	26/722	193/9376	1.74942947770298	CXCL14/GNGT1/CCL3/CCL4/CCL4L2/CCL3L1/GNG2/CCL2/CXCL8/CCR1/DOCK2/PRKCB/CCL8/GNG11/HCK/VAV1/LYN/GRK3/WAS/ARRB2/CXCL12/GNG10/CX3CR1/RASGRP2/CCL13/HRAS	3.03852577935591
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	16/722	100/9376	2.07778393351801	CXCL14/CCL3/CCL4/CCL4L2/CSF1R/CCL3L1/CCL2/CXCL8/CCR1/CCL8/CXCL12/CX3CR1/TNFRSF14/CCL13/IL10RA/TNFSF10	3.12965976682241
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	42/722	362/9376	1.5066803385317	SPP1/GNGT1/LAMA2/IGF2/HGF/CSH1/ANGPT1/COL1A1/IGF1/CSF1R/GNG2/CDK6/PDGFC/PRLR/SYK/AREG/COL1A2/CCND1/COL4A1/PIK3AP1/GNG11/CCND2/TLR2/VTN/COL6A2/FGFR3/PPP2R1A/COL4A2/TLR4/G6PC3/FGF7/GNG10/COL6A1/LPAR5/LAMC3/KITLG/CDK4/LPAR6/KDR/FGF10/HRAS/EIF4EBP1	2.83971890036892
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	21/722	149/9376	1.83026269311569	GNGT1/MT-ND5/MT-ND1/MT-ND3/GNG2/MT-ND2/ITPR2/GABRA3/PRKCB/GNG11/KCNJ5/NDUFA4L2/NDUFB9/GNG10/NDUFC2/NDUFB1/NDUFA5/NDUFS7/GRIA4/NDUFS3/NDUFA9	2.95069410681245
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	12/722	68/9376	2.29167345608604	CD14/CSF1R/FCGR1A/SPI1/RUNX1/CCND1/ITGAM/BCL2A1/CEBPA/PIM1/HRAS/EIF4EBP1	3.08762675480214
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	24/722	181/9376	1.72192038689337	CD14/FCER1G/FCGR2B/FCGR3A/FCGR2A/MRC1/CR1/FCGR1A/CLEC7A/SYK/ITGB2/CALM1/CORO1A/TLR1/CD209/CTSD/ITGAM/TLR2/TLR4/CALM2/LSP1/CTSS/ATP6AP1/IL10RA	2.83268653770206
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	13/722	78/9376	2.16435826408126	CYBA/CYBB/FCGR3A/FCGR2A/CR1/NCF4/FCGR1A/ITGB2/NCF2/PRKCB/ITGAM/TLR2/TLR4	2.9825309008489
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	26/722	204/9376	1.65509749606214	DCN/IGF2/GPC3/LUM/HGF/ACTB/WNT2/COL1A1/IGF1/CD63/ITPR2/COL1A2/CCND1/TWIST1/ANK2/PRKCB/TLR2/VAV1/VTN/PPP1CC/TLR4/EZR/ANK3/KDR/FZD2/HRAS	2.73234032519138
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	4/722	12/9376	4.32871652816251	FCGR2B/CD209/SLAMF1/NCAM2	3.33259489331955
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/722	103/9376	1.89118683269236	CD14/LAMA2/COL3A1/COL1A1/CXCL8/ITGB2/COL1A2/COL4A1/PRKCB/ITGAM/TLR2/COL4A2/TLR4/LAMC3/ARG2	2.62677597310773
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	14/722	97/9376	1.87428963075078	GNGT1/GNG2/CALM1/PRKCB/GNG11/RYR1/RYR2/KCNJ5/GRIN2C/GUCY1B1/CALM2/GRIN2B/GNG10/GRIA4	2.49997922071146
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	13/722	89/9376	1.89685331009368	SPP1/CD36/LAMA2/COL1A1/FREM1/COL1A2/COL4A1/FRAS1/VTN/COL6A2/COL4A2/COL6A1/LAMC3	2.45541264164106
Human Diseases	Substance dependence	hsa05032	Morphine addiction	13/722	91/9376	1.85516422635536	GNGT1/PDE3B/PDE1C/GNG2/PDE1A/GABRA3/PRKCB/GNG11/GRK3/KCNJ5/ARRB2/PDE4A/GNG10	2.36769119252801
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	14/722	101/9376	1.80006033844382	COL3A1/CYBB/COL1A1/CCL2/CXCL8/F3/COL1A2/CCND1/COL4A1/PRKCB/COL4A2/CDK4/PIM1/HRAS	2.33492137470917
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	28/722	248/9376	1.46617817889375	CD14/ACTB/PTPRC/TUBA1B/CXCL8/CYTH4/ARHGEF26/ARPC3/NCKAP1L/PFN1/TLR2/NLRP3/ARPC4/RPS3/TLR4/TAB3/CSE1L/DCTN3/RILP/DYNLT1/DYNLL2/PYCARD/ARPC1A/SNX33/BRK1/HRAS/VPS11/TNFSF10	2.14899674282513
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/722	56/9376	2.08705975464978	CD14/CR1/CXCL8/ITGB2/ITGAM/TLR2/TLR4/SAR1B/PYCARD	2.35659670644415
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	18/722	144/9376	1.62326869806094	RBPJ/ITPR2/PRKCB/PSMB2/RYR1/PSMB3/GRIN2C/ADRM1/PSMD4/PSMB5/GRIN2B/PSMC1/PSMC2/NOP56/PSMC5/PSMD3/PSMC4/SEM1	2.17698008382074
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	28/722	250/9376	1.4544487534626	LGMN/VAMP8/CTSC/CD68/CD63/LAPTM5/NPC2/CTSD/DMXL2/ASAH1/FUCA1/CLTA/CTSB/RRAGA/TLR7/SNAP29/PLA2G15/CTSS/HYAL4/TPP1/ATP6AP1/GLA/BORCS5/BLOC1S6/BLOC1S5/VPS35/VPS11/CLN3	2.10358700935989
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	8/722	48/9376	2.16435826408126	HMGCLL1/HIBADH/ALDH9A1/HMGCL/HADHB/DLD/ALDH7A1/IVD	2.3359243373212
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/722	95/9376	1.77705204840356	CCL3/ANGPT1/CCL3L1/CCL2/CXCL8/MMP1/CD28/CD86/ITGB2/TLR2/TLR4/CXCL12/ATP6AP1	2.19867135082331
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	14/722	105/9376	1.731486611265	CD14/CCL4/CCL4L2/CXCL8/EDA/SYK/PRKCB/LYN/BCL2A1/TLR4/CXCL12/TAB3/CYLD/CCL13	2.17712583790065
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/722	41/9376	2.21714749003446	ALAS2/GATM/GRHPR/PHGDH/DLD/ALDH7A1/PGAM1	2.25592037441147
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/722	41/9376	2.21714749003446	CXCL8/MMP1/CCND1/CDKN2A/FGFR3/CDK4/HRAS	2.25592037441147
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	23/722	201/9376	1.48597731563788	CD14/MAF/IGF1/IGFBP3/CSF1R/FCGR1A/CXCL8/PROM1/CD86/SPI1/RUNX1/NR4A3/CCND2/ITGAM/HOXA11/BMP2K/BCL2A1/LMO2/CEBPA/CDKN2C/REL/RXRB/LYL1	2.01167019583086
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/722	50/9376	2.07778393351801	GATM/P4HA2/ALDH9A1/CNDP2/ARG2/PYCR2/SRM/ALDH7A1	2.20706332171806
Organismal Systems	Endocrine system	hsa04924	Renin secretion	10/722	69/9376	1.88205066441848	ADRB1/PDE3B/PDE1C/ITPR2/PDE1A/CALM1/CTSB/GUCY1B1/CALM2/PTGER4	2.12402200332158
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	23/722	203/9376	1.47133714504046	SPP1/LAMA2/HGF/ACTB/COL1A1/IGF1/PDGFC/COL1A2/CCND1/COL4A1/PRKCB/CCND2/VAV1/VTN/COL6A2/PPP1CC/COL4A2/ILK/COL6A1/LAMC3/KDR/TLN1/HRAS	1.96096472167602
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	7/722	42/9376	2.16435826408126	IDO2/IDO1/ALDH9A1/HAAO/KYNU/DLD/ALDH7A1	2.18435473539373
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	24/722	216/9376	1.4429055093875	CD36/CD14/CCL3/CYBA/CYBB/CCL3L1/CCL2/ABCA1/NCF4/CXCL8/MMP1/CALM1/NCF2/POU2F2/TLR2/NLRP3/VAV1/LYN/TLR4/CALM2/PYCARD/RXRB/HRAS/TNFSF10	1.90211168220702
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	25/722	227/9376	1.43019268551625	GNGT1/CCL3/CCL4/CCL4L2/CCL3L1/GNG2/CDK6/CCL2/CXCL8/ITPR2/CCR1/CALM1/CCND1/CDKN2A/PRKCB/GNG11/CXCL12/CALM2/GNG10/CALR/CDK4/PTGER4/HRAS/EIF4EBP1/IL10RA	1.8951122034815
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	22/722	196/9376	1.4576290349935	GNGT1/UBA52/GNG2/CDK6/CXCL8/CD86/SYK/ITPR2/RPS27A/CCR1/CALM1/CCND1/UBB/CD200R1/GNG11/HCK/LYN/CALM2/GNG10/ATG3/CDK4/HRAS	1.87010528598909
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/722	73/9376	1.77892460061473	HGF/IGF1/CDK6/PDGFC/CCND1/CDKN2A/FGF7/CDK4/FGF10/HRAS	1.9297059299366
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	25/722	233/9376	1.3933636893227	LAMA2/COL3A1/DCN/TNNT3/ACTB/COL1A1/ATP1B1/NEBL/SGCE/COL11A1/COL1A2/COL4A1/FBLN1/ANK2/VCAN/PKP2/COL6A2/TNNT1/COL4A2/DSC2/COL5A1/COL6A1/ANK3/LMNB1/TLN1	1.7561987378298
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	22/722	200/9376	1.42847645429363	FCGR2A/ACTB/TUBA1B/CXCL8/OCLN/CYTH4/ARPC3/NCKAP1L/CLDN11/NLRP3/ARPC4/RPS3/TLR4/TAB3/EZR/LPAR5/NCK2/PYCARD/MYO1F/ARPC1A/BRK1/TNFSF10	1.76913530107356
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/722	37/9376	2.10586209478176	HBA2/HBB/HBA1/IDO2/IDO1/PRKCB	1.94669286923335
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	14/722	116/9376	1.56729391536919	CYBA/CYBB/ACTB/NCF4/OCLN/ITGB2/CLDN11/NCF2/PRKCB/ITGAM/VAV1/CXCL12/EZR/CDH5	1.7757319886717
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/722	76/9376	1.70870389269573	ACTB/ATP1B1/ITPR2/CALM1/PRKCB/KCNQ1/HRH2/CHRM3/CALM2/EZR	1.79174388781372
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	16/722	140/9376	1.48413138108429	SPP1/GNGT1/PDE3B/GNG2/ITPR2/APLNR/CALM1/CCND1/JAG1/GNG11/RYR1/RYR2/CALM2/GNG10/APLN/HRAS	1.66698265694291
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	13/722	109/9376	1.54880683117741	SPP1/CD14/CCL3/CCL4/CCL4L2/CCL3L1/CXCL8/CD86/TLR1/TLR2/TLR4/TLR7/IRF5	1.66459646322389
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/722	22/9376	2.36111810627046	HNMT/ALDH9A1/CNDP2/ALDH7A1	1.84609591118327
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	15/722	133/9376	1.46460333659634	GNGT1/GNG2/ITPR2/CALM1/PRKCB/GNG11/KCNJ5/ARRB2/PPP1CC/PPP2R1A/CALM2/GRIN2B/GNG10/GRIA4/DRD4	1.5586458944423
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/722	60/9376	1.731486611265	IGF1/ITPR2/PRKCB/RYR1/LYN/PPP2R1A/GUCY1B1/HRAS	1.64177280764513
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/722	42/9376	1.85516422635536	FTL/FTH1/CYBB/GPX4/SLC40A1/NCOA4	1.60430177291918
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	24/722	238/9376	1.30952768919202	GNGT1/IGF2/HGF/ANGPT1/IGF1/CSF1R/GNG2/PDGFC/CALM1/PRKCB/GNG11/PLAAT3/PLA2G2A/FGFR3/CALM2/FGF7/GRIN2B/GNG10/RASGRP2/KITLG/KDR/FGF10/REL/HRAS	1.39703793379372
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	12/722	105/9376	1.48413138108429	FCER1G/CLEC7A/SYK/ITPR2/CALM1/CD209/NLRP3/CALM2/LSP1/CYLD/PYCARD/HRAS	1.44092170993309
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	15/722	138/9376	1.41153799831386	FCGR2A/ACTB/CCL2/CXCL8/FYB1/CD4/LCP2/ARPC3/NLRP3/VAV1/WAS/ARPC4/TLR4/PYCARD/ARPC1A	1.40671557735929
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	8/722	65/9376	1.59829533347539	SPP1/CGA/ITPR2/PRKCB/KISS1/KCNJ5/ARRB2/HRAS	1.39804104505585
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	23/722	232/9376	1.2874200019104	TMSB4X/ACTB/PDGFC/IQGAP2/ITGB2/ARPC3/NCKAP1L/PFN1/ITGAM/VAV1/SCIN/FGFR3/PPP1CC/CHRM3/ARPC4/CXCL12/FGF7/EZR/LPAR5/FGF10/ARPC1A/BRK1/HRAS	1.28037935597794
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/722	76/9376	1.53783350342616	IGF1/CDK6/CALM1/CCND1/CDKN2A/PRKCB/CALM2/CDK4/HRAS	1.3597496815768
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	15/722	142/9376	1.37177636455854	CYBA/TYROBP/FCGR2B/FCGR3A/FCGR2A/CSF1R/NCF4/FCGR1A/SPI1/SYK/ITPR2/LCP2/LILRB5/NCF2/CYLD	1.289367754856
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/722	67/9376	1.55058502501344	ITPR2/CALM1/PRKCB/GRIN2C/PPP1CC/CALM2/GRIN2B/HRAS	1.3063395421407
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	18/722	178/9376	1.31320613775717	WNT2/RSPO2/RSPO3/SERPINF1/VANGL2/CCND1/PRKCB/FRZB/LRP6/CCND2/TLE4/BAMBI/ROR1/CXXC4/CTNNBIP1/FZD2/RUVBL1/LGR4	1.21853877737459
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	11/722	100/9376	1.42847645429363	CD36/CD14/CR1/CSF1R/FCGR1A/CD4/ITGAM/CD33/KITLG/CD24/CD37	1.2442062628048
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	16/722	157/9376	1.32342925701784	C1QA/CD36/C1QC/C1QB/SLC2A1/ABCA1/LRP1/MERTK/ALOX5/CX3CR1/CALR/PLA2G15/ARG2/CD24/PTGER4/VPS11	1.1804103624226
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	16/722	157/9376	1.32342925701784	IGFBP3/CDK6/ZFP36L1/CXCL8/ITPR2/CALM1/CCND1/CDKN2A/CCND2/GATA4/PPP1CC/CALM2/CDK4/NBN/HRAS/EIF4EBP1	1.1804103624226
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	28/722	298/9376	1.2201751287438	CXCL14/CCL3/BMP5/CCL4/CSH1/CCL4L2/CSF1R/CCL3L1/CCL2/IL12RB2/CXCL8/PRLR/EDA/CD4/CCR1/CCL8/IL13RA2/TNFRSF19/GDF15/CXCL12/TNFRSF25/CX3CR1/CNTFR/TNFRSF14/CCL13/IL10RA/TNFSF10/EBI3	1.11564774857882
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/722	69/9376	1.50564053153479	FCER1G/SYK/LCP2/VAV1/LYN/ALOX5AP/ALOX5/HRAS	1.21760762513474
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/722	91/9376	1.42704940488874	FCGR2B/SYK/PIK3AP1/LILRB5/PRKCB/VAV1/LYN/NFKBIE/BANK1/HRAS	1.18237068807089
NA	NA	hsa03272	Virion - Hepatitis viruses	6/722	48/9376	1.62326869806094	CD63/OCLN/SCARB1/CLDN11/TGOLN2/VPS4B	1.25039566034243
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	11/722	103/9376	1.3868703439744	C1QA/CCL3/C1QC/C1QB/CCL3L1/CCL2/CXCL8/TLR2/PPP2R1A/TLR4/CALR	1.14030154730829
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	16/722	160/9376	1.29861495844875	NTNG1/PTPRC/PTPRD/CADM3/OCLN/CD28/CD4/CD86/ITGB2/SIGLEC1/CLDN11/VCAN/ITGAM/CDH5/NCAM2/CDH2	1.10038866670437
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/722	10/9376	2.59722991689751	PAPSS2/PAPSS1	1.45960771749463
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/722	29/9376	1.79119304613621	GNGT1/CALM1/CALM2/PDE6G	1.23251192723068
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	17/722	174/9376	1.26876174101315	MAN1A1/STUB1/SSR1/TUSC3/BAG1/RAD23A/DNAJB11/CALR/RNF5/SEC13/SAR1B/UBXN1/UBQLN4/SSR3/ERO1B/STT3A/KRTCAP2	1.03358630661983
NA	NA	hsa04082	Neuroactive ligand signaling	19/722	199/9376	1.23988362866966	GNGT1/ADRB1/GNG2/P2RY1/GABRA3/OGFRL1/PRKCB/GRM7/GNG11/TAC3/HRH2/GRIN2C/CHRM3/GRIN2B/GNG10/HTR2C/P2RY13/GRIA4/DRD4	0.987921810683977
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	8/722	73/9376	1.42313968049178	HGF/CDK6/CCND1/CDKN2A/PRKCB/CDK4/RXRB/HRAS	1.04828522554309
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	13/722	130/9376	1.29861495844875	GNGT1/COL3A1/COL1A1/GNG2/MMP1/COL1A2/COL4A1/GNG11/ARRB2/COL4A2/GNG10/EDNRB/HRAS	0.990266487848419
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/722	52/9376	1.49840187513318	HSD17B2/IGF1/SCARB1/CGA/ALOX5/HSD17B1	1.04094072177951
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/722	63/9376	1.4429055093875	PTGDS/HPGDS/TBXAS1/GPX4/PLAAT3/ALOX5/PLA2G2A	1.01878454339646
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	23/722	250/9376	1.19472576177285	DAB2/FOLR2/CYTH4/PSD3/ARPC3/BIN1/SNX6/GRK3/CLTA/SNX2/ARRB2/FGFR3/ARPC4/ARF5/VPS45/EPN1/SH3GLB2/ARPC1A/STAM/VPS35/HRAS/WASHC3/VPS4B	0.901361440056828
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/722	75/9376	1.385189289012	IGF1/IGFBP3/CDK6/CCND1/CDKN2A/CCND2/EI24/CDK4	0.967354827310927
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/722	43/9376	1.51001739354506	CD36/ABCA1/SCARB1/PLA2G2A/AGPAT1	0.968176136254193
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	16/722	170/9376	1.22222584324589	ACTB/TUBA1B/OCLN/CGNL1/RUNX1/ARPC3/CCND1/CLDN11/GATA4/MYL6/WAS/PPP2R1A/ARPC4/EZR/CDK4/ARPC1A	0.844557707705111
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	18/722	195/9376	1.19872150010654	CYBA/CYBB/FCGR3A/FCGR2A/ACTB/CR1/NCF4/FCGR1A/CLEC7A/SYK/ITGB2/NCF2/PRKCB/ITGAM/TLR2/FPR1/TLR4/TLR7	0.809958859993603
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	9/722	89/9376	1.31320613775717	GNGT1/GNG2/GABRA3/PRKCB/GNG11/GNG10/SLC12A5/NSF/GABARAP	0.857498435288356
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/722	33/9376	1.57407873751364	VAMP8/SNAP29/BET1L/VAMP4	0.954181625156045
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/722	44/9376	1.47569881641904	MAN1A1/MGAT4C/TUSC3/STT3A/KRTCAP2	0.913517424627026
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	32/722	370/9376	1.12312645055027	ADRB1/CSH1/SPX/P2RY1/PRLR/C3AR1/CGA/VIPR1/APLNR/NPY1R/GABRA3/OGFRL1/GRM7/KISS1/TAC3/PTH2R/HRH2/GRIN2C/FPR1/CHRM3/CORT/GRIN2B/LYPD6/APLN/EDNRB/NPY5R/HTR2C/LPAR6/P2RY13/PTGER4/GRIA4/DRD4	0.697962423930982
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	17/722	187/9376	1.18055905313523	CYBA/CYBB/CARD18/CCL2/CXCL8/ITPR2/TRPM2/NLRP3/ANTXR2/CTSB/ANTXR1/TLR4/TAB3/GPSM3/PYCARD/GABARAP/SHARPIN	0.720363563304785
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/722	80/9376	1.29861495844875	HGF/IGF1/PDGFC/PRKCB/FGFR3/KDR/HRAS/EIF4EBP1	0.774736980219258
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/722	116/9376	1.23144521921865	GNGT1/GNG2/ITPR2/PRKCB/GRM7/GNG11/GRK3/GRIN2C/GRIN2B/GNG10/GRIA4	0.724465163925159
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/722	69/9376	1.31743546509294	CALM1/PRKCB/GRIN2C/PPP1CC/CALM2/GRIN2B/GRIA4	0.764400436041314
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	12/722	128/9376	1.21745152354571	ENPP1/PDE3B/PDE1C/PAPSS2/PDE1A/NME3/PAPSS1/GUCY1B1/PDE4A/PDE6G/NT5C/NUDT16	0.715466527845647
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/722	93/9376	1.2567241533375	ADRB1/LYZ/ATP1B1/ITPR2/CALM1/PRKCB/CHRM3/GUCY1B1/CALM2	0.71863740900019
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	10/722	105/9376	1.23677615090357	UBA52/RPS27A/UBB/TAX1BP1/MTX1/GABARAP/HRAS/MUL1/RHOT2/RHOT1	0.704717581965534
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/722	70/9376	1.29861495844875	LAMA2/ACTB/CD28/CD86/SGCE/ITGB2/CCND1	0.724310609058099
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	14/722	154/9376	1.18055905313523	ACTB/ITPR2/CALM1/CCND1/PRKCB/TRPM2/RYR1/MYL6/RYR2/KCNJ5/PPP1CC/GUCY1B1/CALM2/HRAS	0.65254859906394
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/722	59/9376	1.32062538147331	HPGDS/GPX4/GPX7/GSTO1/SRM/G6PD	0.713561892736473
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	7/722	71/9376	1.28032460692131	SLC2A1/FGFR3/SIRT6/TIGAR/PGAM1/HRAS/G6PD	0.684822465745635
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	10/722	107/9376	1.21365883967173	SLC2A1/PDE3B/ITPR2/CALM1/PYGL/G6PC3/CALM2/PRMT1/PHKG1/PGAM1	0.642010461383051
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	22/722	254/9376	1.12478460968002	ADRB1/HGF/PDE1C/PDGFC/ITPR2/PDE1A/CALM1/PRKCB/RYR1/HRH2/RYR2/GRIN2C/FGFR3/CHRM3/CALM2/FGF7/GRIN2B/EDNRB/HTR2C/PHKG1/KDR/FGF10	0.582342706844097
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	18/722	205/9376	1.14024728058915	RBPJ/CDK6/SYK/CCND1/CCND2/TLR2/LYN/ADRM1/PSMD4/PSMC1/CALR/PSMC2/NFKBIE/CDK4/PSMC5/PSMD3/PSMC4/SEM1	0.586420068515168
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/722	37/9376	1.40390806318784	CCND1/NCOA4/RXRB/HRAS	0.711015369948815
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/722	108/9376	1.20242125782292	SUMO3/IPO9/CSE1L/NCBP2/SEC13/NUP214/KPNA5/RAN/KPNA2/NUP54	0.61111194958209
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/722	61/9376	1.27732618863812	FTL/FTH1/ATP1B1/SLC40A1/STEAP1/SLC46A1	0.627639347913966
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/722	38/9376	1.36696311415658	ENPP1/SIRT6/QPRT/NT5C	0.654686020826024
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	11/722	122/9376	1.17088233958494	SLC2A1/ACTB/SLC16A10/ATP1B1/CCND1/PRKCB/GATA4/DIO3/RXRB/HRAS/SLC16A2	0.548729287704968
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/722	62/9376	1.2567241533375	RBPJ/MAML2/HEY1/JAG1/TLE4/PSENEN	0.58578770182893
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/722	16/9376	1.62326869806094	FUT9/GLA	0.720681169638322
Human Diseases	Infectious disease: viral	hsa05162	Measles	12/722	136/9376	1.14583672804302	FCGR2B/CDK6/CD28/CCND1/CD209/CCND2/TLR2/TLR4/TLR7/CDK4/RACK1/SLAMF1	0.494818777706073
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/722	51/9376	1.2731519200478	ACTB/KCNQ1/ATP6AP1/KDELR1/KDELR2	0.564950915796612
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	6/722	63/9376	1.23677615090357	PRDM6/BBOX1/PRDM16/ALDH9A1/DLD/ALDH7A1	0.544639607484356
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/722	28/9376	1.39137316976652	ELOVL2/HACD3/HADHB	0.599040941151893
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	8/722	89/9376	1.16729434467304	ADRB1/PDGFC/TUBA1B/ITPR2/PRKCB/GUCY1B1/HTR2C/HRAS	0.45801988370018
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/722	17/9376	1.52778230405736	PAPSS2/PAPSS1	0.629086482428916
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/722	65/9376	1.19872150010654	AKR1B1/ALDH9A1/DGKB/AGPAT1/GLA/ALDH7A1	0.464353970588747
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	4/722	41/9376	1.26694142287683	GABRA3/GRIN2C/GRIN2B/GRIA4	0.49476222033304
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	21/722	253/9376	1.07790174416695	CD14/ACTB/UBA52/CXCL8/CYTH4/ITPR2/RPS27A/ARPC3/PFN1/UBB/NLRP3/RRAGA/ARPC4/TLR4/TAB3/ILK/UBE2V1/PYCARD/ARPC1A/TLN1/SHARPIN	0.3628142999963
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/722	115/9376	1.12923039865109	GNGT1/GNG2/ITPR2/PRKCB/GNG11/ALOX5/KCNJ5/GNG10/HTR2C/HRAS	0.402745274708376
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	7/722	78/9376	1.16542368065914	LSM2/CNOT8/LSM8/CNOT7/NUDT16/DIS3L/MPHOSPH6	0.423736623441535
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/722	78/9376	1.16542368065914	ACTB/ARHGEF26/ARPC3/CLTA/ARPC4/ILK/ARPC1A	0.423736623441535
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/722	67/9376	1.16293876876008	ALDH9A1/G6PC3/DLD/ALDH7A1/PGAM1/ADPGK	0.386594888907148
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	27/722	333/9376	1.05293104739088	SPP1/LAMA2/RBPJ/WNT2/COL1A1/CDK6/MAML2/HEY1/COL1A2/CCND1/COL4A1/JAG1/CCND2/VTN/COL6A2/PPP2R1A/COL4A2/PSMC1/COL6A1/LAMC3/CDK4/ATP6AP1/FZD2/HES4/PTGER4/HRAS/EIF4EBP1	0.284067880371701
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	12/722	143/9376	1.08974681827867	C1QA/C1QC/C1QB/FCGR3A/FCGR2A/FCGR1A/CD28/C2/CD86/C1R/GRIN2B/SNRPD1	0.312364343623545
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	8/722	93/9376	1.1170881363	LAMA2/CDK6/CCND1/COL4A1/COL4A2/LAMC3/CDK4/RXRB	0.327760024919335
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	14/722	169/9376	1.07577570522382	VAMP8/UBA52/RPS27A/UBB/TAX1BP1/CTSD/CTSB/RRAGA/SNAP29/ATG3/GABARAP/HRAS/MTMR14/VPS11	0.287117761381741
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/722	31/9376	1.2567241533375	KL/ALDH9A1/ALDH7A1	0.413526852507721
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/722	31/9376	1.2567241533375	ALDH9A1/CNDP2/ALDH7A1	0.413526852507721
NA	NA	hsa04981	Folate transport and metabolism	3/722	31/9376	1.2567241533375	FOLR2/SLCO2B1/SLC46A1	0.413526852507721
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	12/722	144/9376	1.08217913204063	C1QA/CD14/C1QC/C1QB/CXCL8/C3AR1/C2/CCND1/ALDH9A1/TLR4/TAB3/ALDH7A1	0.287038855496364
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/722	56/9376	1.1594776414721	MAN1A1/MGAT4C/TUSC3/STT3A/KRTCAP2	0.345725690825261
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/722	56/9376	1.1594776414721	CCND1/DISP1/CCND2/GRK3/ARRB2	0.345725690825261
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/722	133/9376	1.07404244683731	FCER1G/TYROBP/FCGR3A/HCST/SYK/ITGB2/LCP2/PRKCB/VAV1/HRAS/TNFSF10	0.248396743387384
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/722	32/9376	1.21745152354571	AKR1B1/G6PC3/GLA	0.355890848597819
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/722	20/9376	1.29861495844875	NPL/CYB5R4	0.38612439582438
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	10/722	122/9376	1.06443849053176	PTPRC/CD28/CD4/LCP2/VAV1/PPP2R1A/NFKBIE/CDK4/NCK2/HRAS	0.206921833444951
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	12/722	148/9376	1.05293104739088	WNT2/IGF1/CDK6/HEY1/CCND1/JAG1/LRP6/FGF7/CDK4/FZD2/FGF10/HRAS	0.187470675455823
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/722	110/9376	1.06250314782171	SLC2A1/CYBB/ANGPT1/IGF1/PRKCB/TLR4/MKNK1/EIF4EBP1/ELOB	0.190457410949441
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/722	46/9376	1.12923039865109	FTL/FTH1/BLVRB/ALAS2	0.253774844049592
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/722	149/9376	1.04586439606611	FCER1G/PDGFC/CXCL8/SYK/CYTH4/GRM7/DGKB/LPAR5/KITLG/AGPAT1/LPAR6/HRAS	0.162998776540145
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/722	59/9376	1.10052115122776	ENPP1/NME3/DCTPP1/NT5C/DUT	0.223712990532844
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/722	59/9376	1.10052115122776	ADRB1/PDE3B/CGA/NPY1R/PLAAT3	0.223712990532844
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	11/722	137/9376	1.04268354328002	CTSC/ACTB/TUBA1B/ITPR2/CTSD/CTSB/BCL2A1/CTSS/LMNB1/HRAS/TNFSF10	0.145363059734252
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/722	21/9376	1.23677615090357	CHSY3/B3GAT3	0.31374116096597
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/722	21/9376	1.23677615090357	ENPP1/VNN2	0.31374116096597
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/722	34/9376	1.14583672804302	POLR3GL/POLR2F/POLR1A	0.246055020407749
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/722	47/9376	1.10520421995639	ALDH9A1/GRHPR/DLD/ALDH7A1	0.208838389110193
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/722	73/9376	1.06735476036884	CD4/NELFE/FEZ1/RAN/MAP1S/VPS4B	0.166864521149582
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/722	86/9376	1.05701217548154	LAMA2/ACTB/SGCE/PKP2/RYR2/DSC2/CDH2	0.153410389785092
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/722	99/9376	1.04938582500909	IGF1/ITPR2/CALM1/PRKCB/PPP1CC/CALM2/HTR2C/PTGER4	0.142679613352753
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	8/722	101/9376	1.02860590768218	WNT2/CALM1/PRKCB/CALM2/KITLG/EDNRB/FZD2/HRAS	0.0834843849652619
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/722	75/9376	1.038891966759	TKT/PHGDH/ARG2/PYCR2/PGAM1/IDH3G	0.0976723207554324
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	9/722	115/9376	1.01630735878598	GNGT1/GNG2/ITPR2/PRKCB/KCNQ1/GNG11/CHRM3/GNG10/HRAS	0.0508217243201434
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/722	36/9376	1.08217913204063	ENPP1/PYGL/G6PC3	0.142687245376265
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/722	76/9376	1.02522233561744	CD36/PLTP/MMP1/ILK/FABP5/RXRB	0.0637670628660302
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	23/722	300/9376	0.995604801477378	CD14/IGF2/HGF/STMN1/ANGPT1/IGF1/CSF1R/PDGFC/AREG/PRKCB/MAP4K2/ARRB2/FGFR3/DUSP9/FGF7/RASGRP2/MKNK1/KITLG/DUSP3/KDR/FGF10/HRAS/PPM1A	-0.0223479489902817
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/722	77/9376	1.0119077598302	CDK6/RUNX1/CCND1/CDKN2A/CDK4/HRAS	0.0303042190784086
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	13/722	170/9376	0.993058497637282	IGF2/HGF/ACTB/WNT2/CDK6/CCND1/CDKN2A/PRKCB/LRP6/CDK4/GSTO1/FZD2/HRAS	-0.026380817090657
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/722	24/9376	1.08217913204063	HS3ST3A1/B3GAT3	0.116428878288009
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/722	38/9376	1.02522233561744	IGF1/ATP1B1/PRKCB	0.0449982843078673
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	13/722	173/9376	0.975837830048196	ACTB/CDK6/CCL2/CXCL8/PRKCB/NLRP3/TLR4/TLR7/CDK4/PYCARD/KPNA5/KPNA2/TNFSF10	-0.0926488572147631
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/722	93/9376	0.977452119262503	RBPJ/MAF/MAML2/IL12RB2/CD4/JAG1/NFKBIE	-0.0631173591615203
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/722	39/9376	0.998934583422118	DLD/ALDH7A1/MTHFD2	-0.0019257232142883
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/722	134/9376	0.969115640633398	ITPR2/CALM1/KCNMB4/RAMP1/PRKCB/MYL6/PLA2G2A/PPP1CC/GUCY1B1/CALM2	-0.104004901217759
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/722	53/9376	0.980086761093399	ATP1B1/PRKCB/KL/CLTA	-0.0419901850347488
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/722	26/9376	0.998934583422118	PLAAT3/PLA2G2A	-0.00157125296501778
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/722	26/9376	0.998934583422118	SCARB1/SLC46A1	-0.00157125296501778
NA	NA	hsa04519	Cadherin signaling	30/722	404/9376	0.964318038452045	ACTB/WNT2/CDH11/PCDH10/VANGL2/ARPC3/NCKAP1L/GABRA3/LRP6/PKP2/VAV1/KRT1/KRT7/PPP1CC/ARPC4/KRT18/MYO7A/DSC2/PSENEN/CDH5/KRT19/KRT8/KDR/FZD2/MYO1F/FMN1/ARPC1A/CDH2/BRK1/HRAS	-0.211758358873874
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	6/722	82/9376	0.950206067157624	LGMN/CD4/PSME2/CTSB/CALR/CTSS	-0.130806044459213
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/722	41/9376	0.950206067157624	RAD52/NBN/SEM1	-0.0922904976931031
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/722	83/9376	0.938757801288256	CCL4/CCL4L2/NLRP3/POLR3GL/POLR2F/PYCARD	-0.161866748709954
NA	NA	hsa04081	Hormone signaling	16/722	219/9376	0.948759786994523	GNGT1/IGF2/ADRB1/CSH1/SLC16A10/IGF1/GNG2/PRLR/CGA/VIPR1/RAMP1/SLC40A1/GNG11/GNG10/DRD4/SLC16A2	-0.221616539066149
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	10/722	138/9376	0.941025332209242	PDE3B/CALM1/PYGL/PPP1CC/G6PC3/CALM2/MKNK1/PHKG1/HRAS/EIF4EBP1	-0.201586692336435
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/722	27/9376	0.961937006258336	HMGCLL1/HMGCL	-0.0572068503387649
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/722	27/9376	0.961937006258336	ELOVL2/HACD3	-0.0572068503387649
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/722	70/9376	0.927582113177681	CD36/SLC2A1/G6PC3/NFKBIE/RXRB	-0.175654441369775
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/722	70/9376	0.927582113177681	SLC2A1/HGF/FLCN/HRAS/ELOB	-0.175654441369775
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	7/722	98/9376	0.927582113177681	ITPR2/CALM1/PRKCB/CALM2/DGKB/SACM1L/MTMR14	-0.208150516617935
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/722	98/9376	0.927582113177681	ATP1B1/SCARB1/ITPR2/CALM1/PRKCB/KCNJ5/CALM2	-0.208150516617935
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/722	85/9376	0.916669382434414	ENPP1/NME3/DCTPP1/NT5C/NUDT16/DUT	-0.222909524153437
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/722	71/9376	0.914517576372362	PRLR/CGA/CCND1/CCND2/HRAS	-0.208830344112552
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	7/722	99/9376	0.918212596882957	IGF1/CCND1/JAG1/CDKN2A/CDKN2C/CDK4/HRAS	-0.236290373841415
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	7/722	99/9376	0.918212596882957	PDGFC/PRKCB/WAS/DGKB/SLC22A3/HRAS/EIF4EBP1	-0.236290373841415
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/722	43/9376	0.906010436127037	ALDH9A1/HADHB/ALDH7A1	-0.178422253731826
Organismal Systems	Sensory system	hsa04742	Taste transduction	6/722	86/9376	0.906010436127037	SCN9A/PDE1C/P2RY1/PDE1A/GABRA3/CHRM3	-0.252910461803898
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/722	86/9376	0.906010436127037	SLC2A1/ATP1B1/KCNMB4/PRKCB/RYR2/CHRM3	-0.252910461803898
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/722	142/9376	0.914517576372362	CYBA/ACTB/CCL2/CALM1/NCF2/SUMO3/CALM2/CDH5/KDR/GSTO1	-0.296463926003726
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	13/722	184/9376	0.917499698904011	SLIT2/EPHA3/NTNG1/SEMA3G/ROBO2/CXCL12/SEMA6D/ILK/NRP1/NCK2/EPHA6/EPHA5/HRAS	-0.326441397784728
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/722	115/9376	0.903384318920872	ITPR2/NACA/PRKCB/KL/LRP6/ARRB2/PDE4A/RXRB	-0.301101826068089
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	8/722	116/9376	0.895596523068106	TKT/PHGDH/DLD/PGAM1/ADPGK/ESD/IDH3G/G6PD	-0.326801660821378
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/722	102/9376	0.891206344033458	ATP1B1/ITPR2/PRKCB/KCNQ1/RYR2/PLA2G2A/CHRM3	-0.319091990354286
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	11/722	158/9376	0.904099021704828	WNT2/IGF1/PRKCB/LRP6/FLCN/RRAGA/SEC13/FZD2/NPRL3/HRAS/EIF4EBP1	-0.35113896169594
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/722	30/9376	0.865743305632502	DLD/IDH3G	-0.21273036265619
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/722	30/9376	0.865743305632502	PLAAT3/PLA2G2A	-0.21273036265619
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/722	30/9376	0.865743305632502	FOLR2/SLC46A1	-0.21273036265619
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/722	75/9376	0.865743305632502	ATP1B1/CGA/ITPR2/GPX7/PRKCB	-0.337168932522315
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/722	104/9376	0.874067760494353	PLAAT3/PLA2G2A/PLD4/DGKB/PLA2G15/AGPAT1/LYPLA2	-0.373003301991221
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/722	15/9376	0.865743305632502	ST3GAL5	-0.15030251524047
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/722	31/9376	0.837816102225002	TKT/G6PD	-0.261243034215633
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/722	31/9376	0.837816102225002	GRHPR/DLD	-0.261243034215633
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/722	31/9376	0.837816102225002	SRP19/SRPRB	-0.261243034215633
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/722	90/9376	0.865743305632502	CD28/CD4/TLR2/TLR4/NFKBIE/HRAS	-0.36964825171709
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/722	32/9376	0.811634349030471	ATG3/GABARAP	-0.308287614071996
Human Diseases	Immune disease	hsa05310	Asthma	2/722	32/9376	0.811634349030471	FCER1G/PRG2	-0.308287614071996
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/722	48/9376	0.811634349030471	ATP1B1/PRKCB/G6PC3	-0.377897355125714
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/722	93/9376	0.837816102225002	CGA/ITPR2/CALM1/PRKCB/CALM2/HRAS	-0.453994743242376
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/722	33/9376	0.78703936875682	DLD/IDH3G	-0.353963851881984
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/722	94/9376	0.828903164967289	S100A9/CCL2/CXCL8/MMP1/S100A8/TAB3	-0.481538385474154
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	11/722	166/9376	0.860527984514234	ADRB1/PDE3B/ATP1B1/ITPR2/CALM1/KCNMB4/GATA4/PPP1CC/GUCY1B1/CALM2/EDNRB	-0.523669279633679
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/722	17/9376	0.763891152028679	CD209	-0.281428315232942
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	7/722	109/9376	0.83397290909553	CD36/SLC2A1/PRKCB/PYGL/PPP1CC/G6PC3/PPARGC1B	-0.503579934903528
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/722	50/9376	0.779168975069252	CD28/CD86/CXCL12	-0.452213138705057
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/722	110/9376	0.826391337194661	BMP5/DCN/IGSF1/PITX2/BAMBI/PPP2R1A/FST	-0.529014259099696
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	11/722	168/9376	0.850283603746208	FTL/FTH1/CYBB/NLRP3/PYGL/TLR4/CYLD/PYCARD/SHARPIN/TNFSF10/VPS4B	-0.565571012177871
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	11/722	168/9376	0.850283603746208	CSH1/IL12RB2/PRLR/CCND1/CCND2/IL13RA2/CNTFR/PIM1/STAM/HRAS/IL10RA	-0.565571012177871
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	10/722	154/9376	0.843256466525164	IDO2/IDO1/ALAS2/NME3/HAAO/KYNU/QPRT/FLAD1/DLD/MTHFD2	-0.566478231942934
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/722	66/9376	0.78703936875682	MAF/IL12RB2/TLR2/TLR4	-0.501466867857614
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/722	35/9376	0.742065690542145	AKR1B1/TIGAR	-0.441562559346068
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/722	51/9376	0.763891152028679	PLAAT3/PLA2G2A/PLD4	-0.488335977523935
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/722	18/9376	0.721452754693752	FUCA1	-0.34165626711237
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	14/722	214/9376	0.849561187770212	GNGT1/GNG2/CD4/ITPR2/CALM1/PRKCB/GNG11/TLR2/TLR4/CALM2/GNG10/CALR/HRAS/ELOB	-0.643009560700297
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/722	36/9376	0.721452754693752	KL/AKR1B1	-0.483640288634906
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/722	36/9376	0.721452754693752	RNASEH2C/RNASEH1	-0.483640288634906
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	10/722	157/9376	0.827143285636149	BMP5/ACTB/WNT2/AREG/ITGB2/CCND1/CCND2/PPP1CC/PPP2R1A/FZD2	-0.630870128233822
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/722	19/9376	0.683481557078291	HYAL4	-0.39889013686801
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/722	19/9376	0.683481557078291	DLD	-0.39889013686801
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	10/722	158/9376	0.821908201549844	CDK6/CDKN1C/CCND1/CDKN2A/CCND2/PPP2R1A/SMC1A/CDKN2C/CDK4/CDC14B	-0.652078532524197
NA	NA	hsa04382	Cornified envelope formation	14/722	217/9376	0.837816102225002	S100A9/OCLN/S100A11/COL4A1/CLDN11/PKP2/KRT1/KRT7/PPP2R1A/S100A8/KRT18/COL4A2/KRT19/KRT8	-0.698167072780645
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	14/722	217/9376	0.837816102225002	ADRB1/CCND1/JAG1/PRKCB/PAQR7/ARRB2/FGF7/GSTO1/FGF10/KPNA5/RXRB/HRAS/EIF4EBP1/KPNA2	-0.698167072780645
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/722	54/9376	0.721452754693752	CD28/CD86/CGA	-0.592907562836798
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/722	70/9376	0.742065690542145	HPGDS/SULT1A1/GSTO1/SULT1A2	-0.625636966583712
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/722	86/9376	0.755008696772531	AREG/PRKCB/NCK2/HRAS/EIF4EBP1	-0.659231313392887
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/722	38/9376	0.683481557078291	PTPRC/CD4	-0.564689452210289
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	13/722	205/9376	0.823511924869941	RBPJ/CDK6/SYK/CCND1/CDKN2A/CCND2/LYN/SCIN/PSMC1/CDK4/REL/MRPS18B/HRAS	-0.73795476586151
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/722	55/9376	0.708335431881138	ASAH1/GLA/DEGS1	-0.626584367893141
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/722	133/9376	0.781121779518047	IGF1/CCND1/CCND2/G6PC3/PRMT1/GABARAP/HRAS/TNFSF10	-0.734290119903803
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/722	39/9376	0.665956388948079	CD28/CD86	-0.603778418453207
Cellular Processes	Cell motility	hsa04814	Motor proteins	12/722	194/9376	0.803266984607476	TNNT3/ACTB/DNAH8/TUBA1B/MYL6/TNNT1/MYO7A/DCTN3/DYNLT1/KIF26B/DYNLL2/MYO1F	-0.799751863827405
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/722	57/9376	0.683481557078291	ELOVL2/HACD3/HADHB	-0.692305184775184
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	9/722	150/9376	0.779168975069252	HGF/WNT2/CCND1/LRP6/FGF7/FZD2/FGF10/RXRB/HRAS	-0.787489522190536
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	14/722	224/9376	0.811634349030471	SLC2A1/CD4/SPI1/ITGB2/CCND1/CDKN2A/CCND2/CALR/CDKN2C/NRP1/CDK4/RAN/TLN1/HRAS	-0.824163744661159
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/722	105/9376	0.742065690542145	LAMA2/ADRB1/ACTB/IGF1/SGCE/RYR2	-0.767690673969586
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	6/722	106/9376	0.735065070820049	FOLR2/IGF1/PDGFC/CCND1/SLC46A1/HRAS	-0.792315362725252
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	14/722	226/9376	0.804451744171794	ADRB1/PDE3B/ATP1B1/CGA/NPY1R/CALM1/VAV1/RYR2/GRIN2C/PPP1CC/CALM2/GRIN2B/PDE4A/GRIA4	-0.859495111177735
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/722	23/9376	0.564615199325545	ARG2	-0.603820017063087
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/722	23/9376	0.564615199325545	FUT9	-0.603820017063087
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/722	23/9376	0.564615199325545	ATP1B1	-0.603820017063087
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/722	59/9376	0.660312690736654	CCND1/ILK/HRAS	-0.755984813874415
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	8/722	139/9376	0.747404292632376	ITPR2/CALM1/CTSD/KCNJ5/KRT18/CALM2/KRT19/HRAS	-0.866590024984001
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/722	60/9376	0.649307479224377	PRKCB/KDR/HRAS	-0.787105923180538
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	5/722	93/9376	0.698180085187502	ACTB/WAS/PTPRJ/CDH5/FARP2	-0.844872127323231
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	9/722	155/9376	0.754034492002502	WNT2/CDK6/SCARB1/ITPR2/CCND1/CDKN2A/CDKN2C/CDK4/FZD2	-0.89186031463362
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/722	77/9376	0.674605173220132	CDK6/CCND1/CDKN2A/CDK4	-0.828101696568599
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/722	125/9376	0.727224376731302	FCER1G/PRKCB/CTSD/ASAH1/PPP2R1A/DEGS1/HRAS	-0.886772087038214
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/722	44/9376	0.590279526567615	GTF2F1/TAF9	-0.786814637304485
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/722	44/9376	0.590279526567615	CD28/CD86	-0.786814637304485
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/722	44/9376	0.590279526567615	DYNLL2/NSF	-0.786814637304485
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	8/722	142/9376	0.731614061097889	UBA52/RPS27A/UBB/STUB1/UBE2F/UBE2L3/UBA7/ELOB	-0.930796598347618
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/722	62/9376	0.628362076668752	IGF1/HRAS/SOD1	-0.847995493180132
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/722	79/9376	0.657526561239875	SYT1/CLTA/NAPA/NSF	-0.882906707594296
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	6/722	112/9376	0.695686584883261	LAMA2/TLR2/ALOX5/TLR4/LAMC3/IL10RA	-0.935786181032947
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/722	45/9376	0.577162203755001	CD28/CD86	-0.821224229608453
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/722	144/9376	0.721452754693752	WNT2/IGF1/TBX3/FGFR3/DUSP9/FZD2/HRAS/ISL1	-0.972921963386551
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/722	82/9376	0.633470711438416	NME3/GSTO1/DUT/TPMT	-0.962853176650244
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/722	99/9376	0.655866140630684	LAMA2/ACTB/IGF1/SGCE/RYR2	-0.994230348229751
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/722	28/9376	0.463791056588841	FUT9	-0.820728488635808
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/722	28/9376	0.463791056588841	AKR1B1	-0.820728488635808
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/722	28/9376	0.463791056588841	SLC4A1	-0.820728488635808
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/722	49/9376	0.530046921815818	GRIN2C/GRIN2B	-0.952636772849339
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/722	29/9376	0.447798261534053	RASSF4	-0.860213865908557
Genetic Information Processing	Transcription	hsa03040	Spliceosome	14/722	243/9376	0.748173227089817	LSM2/SNIP1/PRPF4/LSM8/BUD31/NCBP2/U2AF2/BCAS2/PPIH/SNRPD1/CDC5L/CHERP/SF3B6/PUF60	-1.14879913444233
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/722	30/9376	0.432871652816251	PIGZ	-0.898617529184538
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/722	154/9376	0.674605173220132	ADRB1/ATP1B1/CALM1/KCNQ1/RYR2/PPP1CC/PPP2R1A/CALM2	-1.17599164744637
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	7/722	138/9376	0.658717732546469	IGF1/ITPR2/CALM1/PPP1CC/PPP2R1A/CALM2/SMC1A	-1.16656805415387
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/722	122/9376	0.638663094319059	CD36/IGF1/CCND1/PPP2R1A/G6PC3/EIF4EBP1	-1.16030798359512
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/722	122/9376	0.638663094319059	CSH1/IGF1/IGFBP3/ITPR2/PRKCB/HRAS	-1.16030798359512
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/722	71/9376	0.548710545823417	CXCL8/LYN/ATP6AP1	-1.10248315397074
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	8/722	156/9376	0.665956388948079	CDK6/OCLN/SCARB1/CCND1/CLDN11/PPP2R1A/CDK4/HRAS	-1.21519451339149
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/722	32/9376	0.405817174515235	DLD	-0.972466076741811
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/722	72/9376	0.541089566020314	CXCL8/CYLD/SIKE1	-1.12902906174874
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/722	90/9376	0.577162203755001	IGF1/KL/HRAS/EIF4EBP1	-1.16419708438546
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/722	54/9376	0.480968503129168	PHGDH/SRM	-1.1047953445272
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/722	109/9376	0.595694935068236	CD4/RUNX1/NFKBIE/RXRB/EBI3	-1.226305400946
Human Diseases	Substance dependence	hsa05034	Alcoholism	10/722	191/9376	0.679903119606677	GNGT1/GNG2/CALM1/GNG11/GRIN2C/PPP1CC/CALM2/GRIN2B/GNG10/HRAS	-1.29093488363886
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/722	34/9376	0.381945576014339	BHLHE41	-1.04277842726994
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/722	36/9376	0.360726377346876	ST6GALNAC1	-1.10996782264608
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/722	79/9376	0.493144920929906	HPGDS/AKR7A2/GSTO1	-1.30668746373252
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/722	38/9376	0.341740778539146	RENBP	-1.17437718872845
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/722	117/9376	0.554963657456732	ACTB/CHRAC1/ACTR6/BRD9/RUVBL1	-1.39911095832159
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/722	120/9376	0.541089566020314	CALM1/CALM2/NFKBIE/BEX3/HRAS	-1.46134471650031
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/722	83/9376	0.469378900644128	HMGCLL1/HMGCL/SOD1	-1.4024629088499
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/722	63/9376	0.412258716967858	RAD23A/POLR2F	-1.35194013616405
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/722	63/9376	0.412258716967858	WNT2/FZD2	-1.35194013616405
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/722	65/9376	0.399573833368847	SCARB1/ITPR2	-1.40302017834546
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/722	66/9376	0.39351968437841	HSD17B2/HSD17B1	-1.42810331898749
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/722	87/9376	0.447798261534053	AREG/CCND1/HRAS	-1.49457841567459
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/722	44/9376	0.295139763283808	NTHL1	-1.35359199128165
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	8/722	180/9376	0.577162203755001	CCL2/SYK/POU2F2/TLR2/PPP1CC/CALR/TNFRSF14/EIF4EBP1	-1.65446034989954
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/722	45/9376	0.288581101877501	ABCA1	-1.38169870746614
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/722	90/9376	0.432871652816251	SLC2A1/ATP1B1/SCARB1	-1.56147150071965
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/722	73/9376	0.355784920122946	HPGDS/GSTO1	-1.59597688763743
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/722	49/9376	0.265023460907909	GXYLT2	-1.48986294764998
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/722	75/9376	0.346297322253001	CDKN2A/GSTO1	-1.64169269235556
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/722	119/9376	0.436509229730673	CCL2/JAG1/TAB3/CYLD	-1.78677944311262
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/722	78/9376	0.332978194474039	SACM1L/MTMR14	-1.7085919410646
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/722	103/9376	0.378237366538472	PPP1CC/PPP2R1A/NCBP2	-1.8326473042906
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	6/722	163/9376	0.478017776116106	CXCL8/PRKCB/TLR2/TLR4/ATP6AP1/HRAS	-1.94175651742294
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	14/722	323/9376	0.56286716465271	ZEB2/STMN1/IGF2BP1/CDK6/ZFPM2/CCND1/MARCKS/CDKN2A/PRKCB/CCND2/FGFR3/EZR/PIM1/HRAS	-2.30921421573831
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/722	68/9376	0.19097278800717	DHRS4L2	-1.93390524001421
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/722	110/9376	0.236111810627046	IGF1/PDE3B	-2.32769343422254
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/722	83/9376	0.156459633548043	AUTS2	-2.22952701560986
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	5/722	183/9376	0.354812830177255	EIF6/RBM28/NOP56/UTP14A/RAN	-2.54582430740814
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/722	449/9376	0.202456675036554	PDE1C/PDE1A/CALM1/GRK3/ARRB2/CALM2/OR9Q1	-5.00230858526701