ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 71/1250 175/18639 0.405714285714286 6.04968685714286 1.09738073046181e-37 1.22906641811723e-34 GO:0009055 electron transfer activity 30/1250 116/18639 0.258620689655172 3.85634482758621 8.51033776374271e-11 4.76578914769592e-08 GO:1990948 ubiquitin ligase inhibitor activity 8/1250 11/18639 0.727272727272727 10.8445090909091 5.50507358791193e-08 1.7546821329943e-05 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 19/1250 68/18639 0.279411764705882 4.16636470588235 6.26672190355108e-08 1.7546821329943e-05 GO:0019843 rRNA binding 17/1250 65/18639 0.261538461538462 3.89985230769231 8.65087605351654e-07 0.000161483019665642 GO:0038024 cargo receptor activity 17/1250 65/18639 0.261538461538462 3.89985230769231 8.65087605351654e-07 0.000161483019665642 GO:0048027 mRNA 5'-UTR binding 10/1250 24/18639 0.416666666666667 6.213 1.46067914953688e-06 0.0002337086639259 GO:0055105 ubiquitin-protein transferase inhibitor activity 8/1250 15/18639 0.533333333333333 7.95264 1.68300349875128e-06 0.00023562048982518 GO:0005201 extracellular matrix structural constituent 29/1250 168/18639 0.172619047619048 2.57395714285714 2.31626767135857e-06 0.000288246643546844 GO:0001540 amyloid-beta binding 18/1250 83/18639 0.216867469879518 3.23375421686747 7.63701426716435e-06 0.000855345597922408 GO:0031720 haptoglobin binding 6/1250 10/18639 0.6 8.94672 1.49313557744032e-05 0.00150496522689361 GO:0015078 proton transmembrane transporter activity 29/1250 185/18639 0.156756756756757 2.33743135135135 1.6124627431003e-05 0.00150496522689361 GO:0003954 NADH dehydrogenase activity 12/1250 44/18639 0.272727272727273 4.06669090909091 2.21745480353529e-05 0.00177396384282823 GO:0030020 extracellular matrix structural constituent conferring tensile strength 12/1250 44/18639 0.272727272727273 4.06669090909091 2.21745480353529e-05 0.00177396384282823 GO:0019864 IgG binding 6/1250 11/18639 0.545454545454545 8.13338181818182 3.09784999400111e-05 0.00216849499580078 GO:0048407 platelet-derived growth factor binding 6/1250 11/18639 0.545454545454545 8.13338181818182 3.09784999400111e-05 0.00216849499580078 GO:0008137 NADH dehydrogenase (ubiquinone) activity 11/1250 41/18639 0.268292682926829 4.00056585365854 5.74015440501464e-05 0.00378174878448023 GO:0016651 oxidoreductase activity, acting on NAD(P)H 17/1250 88/18639 0.193181818181818 2.88057272727273 6.54994108063386e-05 0.00407551889461662 GO:0016504 peptidase activator activity 13/1250 57/18639 0.228070175438596 3.4008 7.94975392069505e-05 0.00468617073219919 GO:0035325 Toll-like receptor binding 6/1250 13/18639 0.461538461538462 6.88209230769231 0.000102356142439374 0.00572974165232104 GO:0022853 active monoatomic ion transmembrane transporter activity 20/1250 118/18639 0.169491525423729 2.5273220338983 0.00010743265598102 0.00572974165232104 GO:0005344 oxygen carrier activity 6/1250 14/18639 0.428571428571429 6.39051428571429 0.000168963346985237 0.00788654914953922 GO:0019763 immunoglobulin receptor activity 6/1250 14/18639 0.428571428571429 6.39051428571429 0.000168963346985237 0.00788654914953922 GO:0016209 antioxidant activity 16/1250 86/18639 0.186046511627907 2.77417674418605 0.00016899748177584 0.00788654914953922 GO:0004129 cytochrome-c oxidase activity 6/1250 15/18639 0.4 5.96448 0.000265654159876889 0.0119013063624846 GO:0005044 scavenger receptor activity 8/1250 27/18639 0.296296296296296 4.41813333333333 0.000281066310921551 0.0121074718550822 GO:0016675 oxidoreductase activity, acting on a heme group of donors 6/1250 16/18639 0.375 5.5917 0.000401002607690751 0.0166341822449497 GO:0061133 endopeptidase activator activity 7/1250 22/18639 0.318181818181818 4.74447272727273 0.00041820248559151 0.0167280994236604 GO:0055106 ubiquitin-protein transferase regulator activity 9/1250 36/18639 0.25 3.7278 0.000480684611136657 0.0185643711887261 GO:0045296 cadherin binding 39/1250 334/18639 0.116766467065868 1.74112814371257 0.000519518032444735 0.0193953398779368 GO:0033218 amide binding 31/1250 247/18639 0.125506072874494 1.87144615384615 0.000565081322857722 0.0204158413419564 GO:0042277 peptide binding 31/1250 249/18639 0.124497991967871 1.85641445783133 0.000648159171886668 0.0226855710160334 GO:0097371 MDM2/MDM4 family protein binding 5/1250 12/18639 0.416666666666667 6.213 0.000715578653095538 0.0242863058020304 GO:0019838 growth factor binding 20/1250 136/18639 0.147058823529412 2.19282352941176 0.000739283938309954 0.0243528826737397 GO:0005518 collagen binding 13/1250 72/18639 0.180555555555556 2.6923 0.000902618518685456 0.0288837925979346 GO:0019211 phosphatase activator activity 7/1250 25/18639 0.28 4.175136 0.000987138053131848 0.0307109616529908 GO:0038187 pattern recognition receptor activity 10/1250 48/18639 0.208333333333333 3.1065 0.00111328308371553 0.0332739173592681 GO:0005178 integrin binding 22/1250 161/18639 0.136645962732919 2.03755527950311 0.00112893648183231 0.0332739173592681 GO:0004601 peroxidase activity 11/1250 57/18639 0.192982456140351 2.8776 0.00124866613153052 0.0358591299311329 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 11/1250 58/18639 0.189655172413793 2.82798620689655 0.00144915417584613 0.0405763169236917 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 11/1250 59/18639 0.186440677966102 2.78005423728814 0.00167525666017403 0.0457631087657295 GO:0004857 enzyme inhibitor activity 44/1250 416/18639 0.105769230769231 1.57714615384615 0.00183993909159115 0.0490650424424307 GO:0072542 protein phosphatase activator activity 6/1250 21/18639 0.285714285714286 4.26034285714286 0.00203343685402526 0.0529639366629834 GO:0031386 protein tag activity 5/1250 15/18639 0.333333333333333 4.9704 0.00229033648283702 0.0570039302394992 GO:0141047 molecular tag activity 5/1250 15/18639 0.333333333333333 4.9704 0.00229033648283702 0.0570039302394992 GO:0048306 calcium-dependent protein binding 13/1250 80/18639 0.1625 2.42307 0.00244162011849822 0.0594481420156089 GO:0003785 actin monomer binding 7/1250 29/18639 0.241379310344828 3.59925517241379 0.00253247549309504 0.0601825943325801 GO:0008009 chemokine activity 9/1250 45/18639 0.2 2.98224 0.00262629811992765 0.0601825943325801 GO:0008201 heparin binding 22/1250 172/18639 0.127906976744186 1.90724651162791 0.00265055692776319 0.0601825943325801 GO:0043394 proteoglycan binding 8/1250 37/18639 0.216216216216216 3.22404324324324 0.0026867229612759 0.0601825943325801 GO:0001664 G protein-coupled receptor binding 33/1250 297/18639 0.111111111111111 1.6568 0.00301575877149596 0.0656221611082696 GO:0047429 nucleoside triphosphate diphosphatase activity 4/1250 10/18639 0.4 5.96448 0.00304674319431252 0.0656221611082696 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 5/1250 16/18639 0.3125 4.65975 0.00314912460790351 0.0665475388839987 GO:0005539 glycosaminoglycan binding 28/1250 242/18639 0.115702479338843 1.72526280991736 0.00340616660383817 0.0706464184499769 GO:0015399 primary active transmembrane transporter activity 21/1250 166/18639 0.126506024096386 1.88635662650602 0.00373001342576447 0.0759566370337491 GO:0140375 immune receptor activity 20/1250 156/18639 0.128205128205128 1.91169230769231 0.00393387393431491 0.0786774786862982 GO:0030169 low-density lipoprotein particle binding 5/1250 17/18639 0.294117647058824 4.38564705882353 0.00421762556817883 0.0789245042766843 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 6/1250 24/18639 0.25 3.7278 0.00424285205478391 0.0789245042766843 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 6/1250 24/18639 0.25 3.7278 0.00424285205478391 0.0789245042766843 GO:0001851 complement component C3b binding 4/1250 11/18639 0.363636363636364 5.42225454545455 0.00453530033112938 0.0789245042766843 GO:0140031 phosphorylation-dependent protein binding 4/1250 11/18639 0.363636363636364 5.42225454545455 0.00453530033112938 0.0789245042766843 GO:0043425 bHLH transcription factor binding 7/1250 32/18639 0.21875 3.261825 0.00458043998034328 0.0789245042766843 GO:0071813 lipoprotein particle binding 7/1250 32/18639 0.21875 3.261825 0.00458043998034328 0.0789245042766843 GO:0071814 protein-lipid complex binding 7/1250 32/18639 0.21875 3.261825 0.00458043998034328 0.0789245042766843 GO:0140142 nucleocytoplasmic carrier activity 7/1250 32/18639 0.21875 3.261825 0.00458043998034328 0.0789245042766843 GO:0050840 extracellular matrix binding 11/1250 67/18639 0.164179104477612 2.44810746268657 0.00471584071744166 0.0800263879323432 GO:0061134 peptidase regulator activity 26/1250 226/18639 0.115044247787611 1.71544778761062 0.00501962260563882 0.0839101092285893 GO:1901681 sulfur compound binding 30/1250 275/18639 0.109090909090909 1.62667636363636 0.00588883699476466 0.0969926093255355 GO:0005021 vascular endothelial growth factor receptor activity 9/1250 51/18639 0.176470588235294 2.63138823529412 0.00628922578567837 0.10064808625169 GO:0005049 nuclear export signal receptor activity 4/1250 12/18639 0.333333333333333 4.9704 0.0064451611701463 0.10064808625169 GO:0004112 cyclic-nucleotide phosphodiesterase activity 6/1250 26/18639 0.230769230769231 3.44104615384615 0.00647023411618007 0.10064808625169 GO:0019865 immunoglobulin binding 6/1250 26/18639 0.230769230769231 3.44104615384615 0.00647023411618007 0.10064808625169 GO:0015026 coreceptor activity 10/1250 61/18639 0.163934426229508 2.44445901639344 0.00697340586130424 0.105806025754429 GO:0051015 actin filament binding 24/1250 209/18639 0.114832535885167 1.71229090909091 0.00699075527306049 0.105806025754429 GO:0042379 chemokine receptor binding 11/1250 72/18639 0.152777777777778 2.2781 0.00818075116204445 0.122165884019864 GO:0008035 high-density lipoprotein particle binding 4/1250 13/18639 0.307692307692308 4.58806153846154 0.00882130270254214 0.128309857491522 GO:0070700 BMP receptor binding 4/1250 13/18639 0.307692307692308 4.58806153846154 0.00882130270254214 0.128309857491522 GO:0140313 molecular sequestering activity 9/1250 55/18639 0.163636363636364 2.44001454545455 0.0103502606883031 0.148619127832045 GO:0001846 opsonin binding 5/1250 21/18639 0.238095238095238 3.55028571428571 0.0110913987430311 0.157245146736643 GO:0019208 phosphatase regulator activity 15/1250 117/18639 0.128205128205128 1.91169230769231 0.0115341717661011 0.161478404725416 GO:0042578 phosphoric ester hydrolase activity 36/1250 363/18639 0.0991735537190083 1.47879669421488 0.0121363626847074 0.166122000669425 GO:0098631 cell adhesion mediator activity 11/1250 76/18639 0.144736842105263 2.1582 0.0121625036204401 0.166122000669425 GO:0030021 extracellular matrix structural constituent conferring compression resistance 5/1250 22/18639 0.227272727272727 3.38890909090909 0.0135773543315144 0.183212492184291 GO:0005523 tropomyosin binding 4/1250 15/18639 0.266666666666667 3.97632 0.0151266687791759 0.183886980312556 GO:0005004 GPI-linked ephrin receptor activity 8/1250 49/18639 0.163265306122449 2.43448163265306 0.0154333715619466 0.183886980312556 GO:0005008 hepatocyte growth factor receptor activity 8/1250 49/18639 0.163265306122449 2.43448163265306 0.0154333715619466 0.183886980312556 GO:0005009 insulin receptor activity 8/1250 49/18639 0.163265306122449 2.43448163265306 0.0154333715619466 0.183886980312556 GO:0005011 macrophage colony-stimulating factor receptor activity 8/1250 49/18639 0.163265306122449 2.43448163265306 0.0154333715619466 0.183886980312556 GO:0005018 platelet-derived growth factor alpha-receptor activity 8/1250 49/18639 0.163265306122449 2.43448163265306 0.0154333715619466 0.183886980312556 GO:0005020 stem cell factor receptor activity 8/1250 49/18639 0.163265306122449 2.43448163265306 0.0154333715619466 0.183886980312556 GO:0008288 boss receptor activity 8/1250 49/18639 0.163265306122449 2.43448163265306 0.0154333715619466 0.183886980312556 GO:0036332 placental growth factor receptor activity 8/1250 49/18639 0.163265306122449 2.43448163265306 0.0154333715619466 0.183886980312556 GO:0038062 protein tyrosine kinase collagen receptor activity 8/1250 49/18639 0.163265306122449 2.43448163265306 0.0154333715619466 0.183886980312556 GO:0060175 brain-derived neurotrophic factor receptor activity 8/1250 49/18639 0.163265306122449 2.43448163265306 0.0154333715619466 0.183886980312556 GO:0043177 organic acid binding 21/1250 189/18639 0.111111111111111 1.6568 0.0157263198987075 0.185405034595289 GO:0017134 fibroblast growth factor binding 5/1250 23/18639 0.217391304347826 3.2415652173913 0.0164125540910797 0.187572046755197 GO:0031681 G-protein beta-subunit binding 5/1250 23/18639 0.217391304347826 3.2415652173913 0.0164125540910797 0.187572046755197 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 5/1250 23/18639 0.217391304347826 3.2415652173913 0.0164125540910797 0.187572046755197 GO:0005006 epidermal growth factor receptor activity 8/1250 50/18639 0.16 2.385792 0.0173256235812949 0.190242141284807 GO:0005007 fibroblast growth factor receptor activity 8/1250 50/18639 0.16 2.385792 0.0173256235812949 0.190242141284807 GO:0005017 platelet-derived growth factor receptor activity 8/1250 50/18639 0.16 2.385792 0.0173256235812949 0.190242141284807 GO:0005019 platelet-derived growth factor beta-receptor activity 8/1250 50/18639 0.16 2.385792 0.0173256235812949 0.190242141284807 GO:0004714 transmembrane receptor protein tyrosine kinase activity 9/1250 60/18639 0.15 2.23668 0.0178741739779394 0.19435995005138 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 4/1250 16/18639 0.25 3.7278 0.0191191835029334 0.204758261501511 GO:0005010 insulin-like growth factor receptor activity 8/1250 51/18639 0.156862745098039 2.33901176470588 0.0193789068921073 0.204758261501511 GO:0005030 neurotrophin receptor activity 8/1250 51/18639 0.156862745098039 2.33901176470588 0.0193789068921073 0.204758261501511 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 5/1250 24/18639 0.208333333333333 3.1065 0.019615107258526 0.205317010556534 GO:0048487 beta-tubulin binding 7/1250 42/18639 0.166666666666667 2.4852 0.0205297067698078 0.212900662798007 GO:0001848 complement binding 5/1250 25/18639 0.2 2.98224 0.0232011410066996 0.233687862812157 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 5/1250 25/18639 0.2 2.98224 0.0232011410066996 0.233687862812157 GO:0015278 intracellularly gated calcium channel activity 4/1250 17/18639 0.235294117647059 3.50851764705882 0.0237042782520886 0.233687862812157 GO:0019825 oxygen binding 6/1250 34/18639 0.176470588235294 2.63138823529412 0.0239669158510097 0.233687862812157 GO:0005003 ephrin receptor activity 8/1250 53/18639 0.150943396226415 2.25074716981132 0.0239947359137483 0.233687862812157 GO:0005005 transmembrane-ephrin receptor activity 8/1250 53/18639 0.150943396226415 2.25074716981132 0.0239947359137483 0.233687862812157 GO:0038064 collagen receptor activity 8/1250 53/18639 0.150943396226415 2.25074716981132 0.0239947359137483 0.233687862812157 GO:0005031 tumor necrosis factor receptor activity 3/1250 10/18639 0.3 4.47336 0.0252843782398308 0.242038492552226 GO:0016175 superoxide-generating NAD(P)H oxidase activity 3/1250 10/18639 0.3 4.47336 0.0252843782398308 0.242038492552226 GO:0004721 phosphoprotein phosphatase activity 19/1250 175/18639 0.108571428571429 1.61893028571429 0.0258407927425994 0.245268541285689 GO:0031406 carboxylic acid binding 20/1250 187/18639 0.106951871657754 1.5947807486631 0.0261394214832893 0.246018084548605 GO:0030507 spectrin binding 5/1250 26/18639 0.192307692307692 2.86753846153846 0.027184690266347 0.253723775819239 GO:0016791 phosphatase activity 27/1250 273/18639 0.0989010989010989 1.47473406593407 0.0278561488252022 0.257842038712616 GO:0020037 heme binding 16/1250 142/18639 0.112676056338028 1.68013521126761 0.0286286334166663 0.258938297761804 GO:0030228 lipoprotein particle receptor activity 4/1250 18/18639 0.222222222222222 3.3136 0.028899363589487 0.258938297761804 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 4/1250 18/18639 0.222222222222222 3.3136 0.028899363589487 0.258938297761804 GO:0070628 proteasome binding 4/1250 18/18639 0.222222222222222 3.3136 0.028899363589487 0.258938297761804 GO:0098632 cell-cell adhesion mediator activity 8/1250 55/18639 0.145454545454545 2.16890181818182 0.0293304492715751 0.260715104636223 GO:0004725 protein tyrosine phosphatase activity 12/1250 98/18639 0.122448979591837 1.8258612244898 0.030773987727727 0.271392647677593 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 3/1250 11/18639 0.272727272727273 4.06669090909091 0.0330652824555938 0.280553911744433 GO:0010854 adenylate cyclase regulator activity 3/1250 11/18639 0.272727272727273 4.06669090909091 0.0330652824555938 0.280553911744433 GO:0045294 alpha-catenin binding 3/1250 11/18639 0.272727272727273 4.06669090909091 0.0330652824555938 0.280553911744433 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 3/1250 11/18639 0.272727272727273 4.06669090909091 0.0330652824555938 0.280553911744433 GO:0050786 RAGE receptor binding 3/1250 11/18639 0.272727272727273 4.06669090909091 0.0330652824555938 0.280553911744433 GO:0016500 protein-hormone receptor activity 9/1250 67/18639 0.134328358208955 2.00299701492537 0.0341854834596168 0.287877755449405 GO:0043395 heparan sulfate proteoglycan binding 4/1250 19/18639 0.210526315789474 3.1392 0.0347163191388537 0.290166249518777 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 11/1250 89/18639 0.123595505617978 1.84295730337079 0.035446051650763 0.291908660653342 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 11/1250 89/18639 0.123595505617978 1.84295730337079 0.035446051650763 0.291908660653342 GO:0005504 fatty acid binding 7/1250 47/18639 0.148936170212766 2.2208170212766 0.0358995871628126 0.293485676075548 GO:0019887 protein kinase regulator activity 25/1250 255/18639 0.0980392156862745 1.46188235294118 0.0364513350196306 0.295836921898451 GO:0019210 kinase inhibitor activity 11/1250 90/18639 0.122222222222222 1.82248 0.0380354680855744 0.304283744684595 GO:0140793 histone H2AXY142 phosphatase activity 11/1250 90/18639 0.122222222222222 1.82248 0.0380354680855744 0.304283744684595 GO:0140789 histone phosphatase activity 15/1250 136/18639 0.110294117647059 1.64461764705882 0.0392025191773206 0.311395897011341 GO:0061135 endopeptidase regulator activity 19/1250 184/18639 0.103260869565217 1.53974347826087 0.0402947005014106 0.315243590359052 GO:0140297 DNA-binding transcription factor binding 43/1250 488/18639 0.0881147540983607 1.31389672131148 0.0405469092485265 0.315243590359052 GO:0016505 peptidase activator activity involved in apoptotic process 4/1250 20/18639 0.2 2.98224 0.0411617136359645 0.315243590359052 GO:0099604 ligand-gated calcium channel activity 5/1250 29/18639 0.172413793103448 2.57089655172414 0.0416279824658893 0.315243590359052 GO:0004875 complement receptor activity 3/1250 12/18639 0.25 3.7278 0.0419386562174096 0.315243590359052 GO:0045295 gamma-catenin binding 3/1250 12/18639 0.25 3.7278 0.0419386562174096 0.315243590359052 GO:0097677 STAT family protein binding 3/1250 12/18639 0.25 3.7278 0.0419386562174096 0.315243590359052 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 3/1250 12/18639 0.25 3.7278 0.0419386562174096 0.315243590359052 GO:0005125 cytokine activity 23/1250 234/18639 0.0982905982905983 1.46563076923077 0.0423551972650142 0.316252139578773 GO:0097110 scaffold protein binding 9/1250 70/18639 0.128571428571429 1.91715428571429 0.0435932254383963 0.323340480072873 GO:0008083 growth factor activity 17/1250 162/18639 0.104938271604938 1.56475555555556 0.0443548921592134 0.326825521173152 GO:0019207 kinase regulator activity 27/1250 287/18639 0.0940766550522648 1.40279581881533 0.0474211265972726 0.347135044372192 GO:0048020 CCR chemokine receptor binding 7/1250 50/18639 0.14 2.087568 0.0480323681224787 0.348161815094436 GO:0008373 sialyltransferase activity 4/1250 21/18639 0.19047619047619 2.84022857142857 0.0482370818460664 0.348161815094436 GO:0005126 cytokine receptor binding 26/1250 275/18639 0.0945454545454545 1.40978618181818 0.0484939671024393 0.348161815094436 GO:0046906 tetrapyrrole binding 16/1250 152/18639 0.105263157894737 1.5696 0.0488261387409422 0.348313855986339 GO:0003779 actin binding 39/1250 443/18639 0.0880361173814898 1.31272415349887 0.0496935531165906 0.352258098041655 GO:0019905 syntaxin binding 8/1250 61/18639 0.131147540983607 1.95556721311475 0.0500720073984868 0.352708479788083 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/1250 13/18639 0.230769230769231 3.44104615384615 0.0518738622718699 0.358336532701834 GO:0005035 death receptor activity 3/1250 13/18639 0.230769230769231 3.44104615384615 0.0518738622718699 0.358336532701834 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 3/1250 13/18639 0.230769230769231 3.44104615384615 0.0518738622718699 0.358336532701834 GO:0003743 translation initiation factor activity 7/1250 51/18639 0.137254901960784 2.04663529411765 0.0525908733182196 0.358336532701834 GO:0017147 Wnt-protein binding 5/1250 31/18639 0.161290322580645 2.40503225806452 0.053402649139857 0.358336532701834 GO:0070325 lipoprotein particle receptor binding 5/1250 31/18639 0.161290322580645 2.40503225806452 0.053402649139857 0.358336532701834 GO:0004860 protein kinase inhibitor activity 10/1250 84/18639 0.119047619047619 1.77514285714286 0.0540620176179745 0.358336532701834 GO:0051117 ATPase binding 10/1250 84/18639 0.119047619047619 1.77514285714286 0.0540620176179745 0.358336532701834 GO:0001530 lipopolysaccharide binding 6/1250 41/18639 0.146341463414634 2.18212682926829 0.0540704232380446 0.358336532701834 GO:0042169 SH2 domain binding 6/1250 41/18639 0.146341463414634 2.18212682926829 0.0540704232380446 0.358336532701834 GO:0008093 cytoskeletal anchor activity 4/1250 22/18639 0.181818181818182 2.71112727272727 0.0559392435159669 0.368540898458135 GO:0005080 protein kinase C binding 7/1250 52/18639 0.134615384615385 2.00727692307692 0.057411702650915 0.376029865315935 GO:0051059 NF-kappaB binding 5/1250 32/18639 0.15625 2.329875 0.0599427268279596 0.390324732833225 GO:0051082 unfolded protein binding 13/1250 121/18639 0.107438016528926 1.60202975206612 0.0620492867080838 0.393242937432841 GO:0017046 peptide hormone binding 7/1250 53/18639 0.132075471698113 1.96940377358491 0.0624968932413533 0.393242937432841 GO:0005161 platelet-derived growth factor receptor binding 3/1250 14/18639 0.214285714285714 3.19525714285714 0.0628293755732475 0.393242937432841 GO:0034236 protein kinase A catalytic subunit binding 3/1250 14/18639 0.214285714285714 3.19525714285714 0.0628293755732475 0.393242937432841 GO:0071933 Arp2/3 complex binding 3/1250 14/18639 0.214285714285714 3.19525714285714 0.0628293755732475 0.393242937432841 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 3/1250 14/18639 0.214285714285714 3.19525714285714 0.0628293755732475 0.393242937432841 GO:0044183 protein folding chaperone 9/1250 75/18639 0.12 1.789344 0.0628486480361416 0.393242937432841 GO:0005158 insulin receptor binding 4/1250 23/18639 0.173913043478261 2.59325217391304 0.0642606518159432 0.397634972562742 GO:0043274 phospholipase binding 4/1250 23/18639 0.173913043478261 2.59325217391304 0.0642606518159432 0.397634972562742 GO:0008081 phosphoric diester hydrolase activity 10/1250 87/18639 0.114942528735632 1.71393103448276 0.0656432328479859 0.403958355987605 GO:0030296 protein tyrosine kinase activator activity 5/1250 33/18639 0.151515151515152 2.25927272727273 0.0669169886692536 0.409546597320022 GO:0044325 transmembrane transporter binding 14/1250 136/18639 0.102941176470588 1.53497647058824 0.0722471219446194 0.439765090097683 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 4/1250 24/18639 0.166666666666667 2.4852 0.0731897607274266 0.443094767647123 GO:0005041 low-density lipoprotein particle receptor activity 3/1250 15/18639 0.2 2.98224 0.0747550522717654 0.450137949163318 GO:0019199 transmembrane receptor protein kinase activity 9/1250 78/18639 0.115384615384615 1.72052307692308 0.0766423964559665 0.459034673960869 GO:0003707 nuclear steroid receptor activity 4/1250 25/18639 0.16 2.385792 0.0827114025789936 0.489877354195455 GO:0120020 cholesterol transfer activity 4/1250 25/18639 0.16 2.385792 0.0827114025789936 0.489877354195455 GO:0030295 protein kinase activator activity 14/1250 139/18639 0.100719424460432 1.50184748201439 0.0831041940153004 0.489877354195455 GO:0004722 protein serine/threonine phosphatase activity 11/1250 103/18639 0.106796116504854 1.59245825242718 0.0841904515565831 0.493682229022895 GO:0005324 long-chain fatty acid transmembrane transporter activity 3/1250 16/18639 0.1875 2.79585 0.0875940989107266 0.508318086943077 GO:0017070 U6 snRNA binding 3/1250 16/18639 0.1875 2.79585 0.0875940989107266 0.508318086943077 GO:0001784 phosphotyrosine residue binding 6/1250 47/18639 0.127659574468085 1.90355744680851 0.0925569451983234 0.518624134725827 GO:0043495 protein-membrane adaptor activity 6/1250 47/18639 0.127659574468085 1.90355744680851 0.0925569451983234 0.518624134725827 GO:0005112 Notch binding 4/1250 26/18639 0.153846153846154 2.29403076923077 0.0928071684540203 0.518624134725827 GO:0008066 glutamate receptor activity 4/1250 26/18639 0.153846153846154 2.29403076923077 0.0928071684540203 0.518624134725827 GO:0008198 ferrous iron binding 4/1250 26/18639 0.153846153846154 2.29403076923077 0.0928071684540203 0.518624134725827 GO:0050750 low-density lipoprotein particle receptor binding 4/1250 26/18639 0.153846153846154 2.29403076923077 0.0928071684540203 0.518624134725827 GO:1990782 protein tyrosine kinase binding 12/1250 117/18639 0.102564102564103 1.52935384615385 0.0930274232424792 0.518624134725827 GO:0000287 magnesium ion binding 21/1250 230/18639 0.091304347826087 1.36145739130435 0.0930745098927599 0.518624134725827 GO:0001786 phosphatidylserine binding 7/1250 59/18639 0.11864406779661 1.76912542372881 0.0985821792964841 0.540185465419461 GO:0022804 active transmembrane transporter activity 38/1250 457/18639 0.0831509846827133 1.23988096280088 0.0998542420743768 0.540185465419461 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 6/1250 48/18639 0.125 1.8639 0.100109286045385 0.540185465419461 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/1250 17/18639 0.176470588235294 2.63138823529412 0.101284774766149 0.540185465419461 GO:0008429 phosphatidylethanolamine binding 3/1250 17/18639 0.176470588235294 2.63138823529412 0.101284774766149 0.540185465419461 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 3/1250 17/18639 0.176470588235294 2.63138823529412 0.101284774766149 0.540185465419461 GO:0019198 transmembrane receptor protein phosphatase activity 3/1250 17/18639 0.176470588235294 2.63138823529412 0.101284774766149 0.540185465419461 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/1250 17/18639 0.176470588235294 2.63138823529412 0.101284774766149 0.540185465419461 GO:0036041 long-chain fatty acid binding 3/1250 17/18639 0.176470588235294 2.63138823529412 0.101284774766149 0.540185465419461 GO:0015252 proton channel activity 4/1250 27/18639 0.148148148148148 2.20906666666667 0.103455785513956 0.549149193249433 GO:0005109 frizzled binding 5/1250 38/18639 0.131578947368421 1.962 0.108122234343017 0.571211804076318 GO:0004896 cytokine receptor activity 10/1250 96/18639 0.104166666666667 1.55325 0.10930408788099 0.574744499655909 GO:0140104 molecular carrier activity 22/1250 249/18639 0.0883534136546185 1.31745542168675 0.112991125585829 0.58933309018936 GO:0004970 glutamate-gated receptor activity 3/1250 18/18639 0.166666666666667 2.4852 0.115761857001481 0.58933309018936 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/1250 18/18639 0.166666666666667 2.4852 0.115761857001481 0.58933309018936 GO:0016854 racemase and epimerase activity 3/1250 18/18639 0.166666666666667 2.4852 0.115761857001481 0.58933309018936 GO:0034185 apolipoprotein binding 3/1250 18/18639 0.166666666666667 2.4852 0.115761857001481 0.58933309018936 GO:0070064 proline-rich region binding 3/1250 18/18639 0.166666666666667 2.4852 0.115761857001481 0.58933309018936 GO:0098641 cadherin binding involved in cell-cell adhesion 3/1250 18/18639 0.166666666666667 2.4852 0.115761857001481 0.58933309018936 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 5/1250 39/18639 0.128205128205128 1.91169230769231 0.117569984475889 0.595829785579164 GO:0019209 kinase activator activity 14/1250 148/18639 0.0945945945945946 1.41051891891892 0.121617123779701 0.613563867717413 GO:0002020 protease binding 13/1250 136/18639 0.0955882352941176 1.42533529411765 0.124748493501568 0.626539518931642 GO:0043236 laminin binding 4/1250 29/18639 0.137931034482759 2.05671724137931 0.126314367057793 0.628764849354348 GO:0051861 glycolipid binding 4/1250 29/18639 0.137931034482759 2.05671724137931 0.126314367057793 0.628764849354348 GO:0005200 structural constituent of cytoskeleton 11/1250 112/18639 0.0982142857142857 1.46449285714286 0.130538054548109 0.64613587133397 GO:0015245 fatty acid transmembrane transporter activity 3/1250 19/18639 0.157894736842105 2.3544 0.130957895350724 0.64613587133397 GO:0008227 G protein-coupled amine receptor activity 5/1250 41/18639 0.121951219512195 1.81843902439024 0.137576480115724 0.65246346826316 GO:0019902 phosphatase binding 17/1250 190/18639 0.0894736842105263 1.33416 0.137682215637617 0.65246346826316 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 4/1250 30/18639 0.133333333333333 1.98816 0.138470729493653 0.65246346826316 GO:0033612 receptor serine/threonine kinase binding 4/1250 30/18639 0.133333333333333 1.98816 0.138470729493653 0.65246346826316 GO:0004983 neuropeptide Y receptor activity 2/1250 10/18639 0.2 2.98224 0.14143058387721 0.65246346826316 GO:0005381 iron ion transmembrane transporter activity 2/1250 10/18639 0.2 2.98224 0.14143058387721 0.65246346826316 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/1250 10/18639 0.2 2.98224 0.14143058387721 0.65246346826316 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/1250 10/18639 0.2 2.98224 0.14143058387721 0.65246346826316 GO:0043422 protein kinase B binding 2/1250 10/18639 0.2 2.98224 0.14143058387721 0.65246346826316 GO:0050308 sugar-phosphatase activity 2/1250 10/18639 0.2 2.98224 0.14143058387721 0.65246346826316 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/1250 10/18639 0.2 2.98224 0.14143058387721 0.65246346826316 GO:0070097 delta-catenin binding 2/1250 10/18639 0.2 2.98224 0.14143058387721 0.65246346826316 GO:0071723 lipopeptide binding 2/1250 10/18639 0.2 2.98224 0.14143058387721 0.65246346826316 GO:0140940 histone H2A methyltransferase activity 2/1250 10/18639 0.2 2.98224 0.14143058387721 0.65246346826316 GO:1990259 histone H2AQ104 methyltransferase activity 2/1250 10/18639 0.2 2.98224 0.14143058387721 0.65246346826316 GO:0005096 GTPase activator activity 23/1250 271/18639 0.0848708487084871 1.26552619926199 0.145416936737763 0.65246346826316 GO:0008238 exopeptidase activity 10/1250 102/18639 0.0980392156862745 1.46188235294118 0.145767693714794 0.65246346826316 GO:0000339 RNA cap binding 3/1250 20/18639 0.15 2.23668 0.146804280359211 0.65246346826316 GO:0001614 purinergic nucleotide receptor activity 3/1250 20/18639 0.15 2.23668 0.146804280359211 0.65246346826316 GO:0010851 cyclase regulator activity 3/1250 20/18639 0.15 2.23668 0.146804280359211 0.65246346826316 GO:0016004 phospholipase activator activity 3/1250 20/18639 0.15 2.23668 0.146804280359211 0.65246346826316 GO:0016502 nucleotide receptor activity 3/1250 20/18639 0.15 2.23668 0.146804280359211 0.65246346826316 GO:0043024 ribosomal small subunit binding 3/1250 20/18639 0.15 2.23668 0.146804280359211 0.65246346826316 GO:0061608 nuclear import signal receptor activity 3/1250 20/18639 0.15 2.23668 0.146804280359211 0.65246346826316 GO:0140939 histone H4 methyltransferase activity 3/1250 20/18639 0.15 2.23668 0.146804280359211 0.65246346826316 GO:0035401 histone H3Y41 kinase activity 11/1250 115/18639 0.0956521739130435 1.42628869565217 0.148566977532928 0.655098483609763 GO:0140801 histone H2AXY142 kinase activity 11/1250 115/18639 0.0956521739130435 1.42628869565217 0.148566977532928 0.655098483609763 GO:0008235 metalloexopeptidase activity 7/1250 66/18639 0.106060606060606 1.58149090909091 0.152292184145748 0.668891161738187 GO:0072341 modified amino acid binding 9/1250 91/18639 0.0989010989010989 1.47473406593407 0.155896337117368 0.682046474888483 GO:0033293 monocarboxylic acid binding 8/1250 79/18639 0.10126582278481 1.50999493670886 0.158859982088196 0.684033850211849 GO:0048156 tau protein binding 5/1250 43/18639 0.116279069767442 1.73386046511628 0.15896408801367 0.684033850211849 GO:0051020 GTPase binding 26/1250 315/18639 0.0825396825396825 1.23076571428571 0.159691134331668 0.684033850211849 GO:0016798 hydrolase activity, acting on glycosyl bonds 12/1250 130/18639 0.0923076923076923 1.37641846153846 0.162512952749623 0.684033850211849 GO:0005248 voltage-gated sodium channel activity 3/1250 21/18639 0.142857142857143 2.13017142857143 0.163232146778069 0.684033850211849 GO:0120015 sterol transfer activity 4/1250 32/18639 0.125 1.8639 0.164092076812675 0.684033850211849 GO:0005536 D-glucose binding 2/1250 11/18639 0.181818181818182 2.71112727272727 0.165511761970903 0.684033850211849 GO:0008046 axon guidance receptor activity 2/1250 11/18639 0.181818181818182 2.71112727272727 0.165511761970903 0.684033850211849 GO:0008199 ferric iron binding 2/1250 11/18639 0.181818181818182 2.71112727272727 0.165511761970903 0.684033850211849 GO:0015173 aromatic amino acid transmembrane transporter activity 2/1250 11/18639 0.181818181818182 2.71112727272727 0.165511761970903 0.684033850211849 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/1250 11/18639 0.181818181818182 2.71112727272727 0.165511761970903 0.684033850211849 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/1250 11/18639 0.181818181818182 2.71112727272727 0.165511761970903 0.684033850211849 GO:0019203 carbohydrate phosphatase activity 2/1250 11/18639 0.181818181818182 2.71112727272727 0.165511761970903 0.684033850211849 GO:0032050 clathrin heavy chain binding 2/1250 11/18639 0.181818181818182 2.71112727272727 0.165511761970903 0.684033850211849 GO:0099528 G protein-coupled neurotransmitter receptor activity 2/1250 11/18639 0.181818181818182 2.71112727272727 0.165511761970903 0.684033850211849 GO:0019955 cytokine binding 13/1250 144/18639 0.0902777777777778 1.34615 0.169035343898824 0.685535099944899 GO:0030145 manganese ion binding 7/1250 68/18639 0.102941176470588 1.53497647058824 0.169722452520685 0.685535099944899 GO:0030547 signaling receptor inhibitor activity 5/1250 44/18639 0.113636363636364 1.69445454545455 0.170134668527994 0.685535099944899 GO:0051213 dioxygenase activity 9/1250 93/18639 0.0967741935483871 1.44301935483871 0.170730376041201 0.685535099944899 GO:0051219 phosphoprotein binding 9/1250 93/18639 0.0967741935483871 1.44301935483871 0.170730376041201 0.685535099944899 GO:0005543 phospholipid binding 39/1250 497/18639 0.0784708249496982 1.17009416498994 0.172782914940692 0.685535099944899 GO:0001618 virus receptor activity 8/1250 81/18639 0.0987654320987654 1.47271111111111 0.175056284450215 0.685535099944899 GO:0033192 calmodulin-dependent protein phosphatase activity 8/1250 81/18639 0.0987654320987654 1.47271111111111 0.175056284450215 0.685535099944899 GO:0140791 histone H2AXS140 phosphatase activity 8/1250 81/18639 0.0987654320987654 1.47271111111111 0.175056284450215 0.685535099944899 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 8/1250 81/18639 0.0987654320987654 1.47271111111111 0.175056284450215 0.685535099944899 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 8/1250 81/18639 0.0987654320987654 1.47271111111111 0.175056284450215 0.685535099944899 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 8/1250 81/18639 0.0987654320987654 1.47271111111111 0.175056284450215 0.685535099944899 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 8/1250 81/18639 0.0987654320987654 1.47271111111111 0.175056284450215 0.685535099944899 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 8/1250 81/18639 0.0987654320987654 1.47271111111111 0.175056284450215 0.685535099944899 GO:1990439 MAP kinase serine/threonine phosphatase activity 8/1250 81/18639 0.0987654320987654 1.47271111111111 0.175056284450215 0.685535099944899 GO:0042562 hormone binding 9/1250 94/18639 0.0957446808510638 1.42766808510638 0.178384667078804 0.689055651810374 GO:0033691 sialic acid binding 3/1250 22/18639 0.136363636363636 2.03334545454545 0.180173131503663 0.689055651810374 GO:0140517 protein-RNA adaptor activity 3/1250 22/18639 0.136363636363636 2.03334545454545 0.180173131503663 0.689055651810374 GO:0019888 protein phosphatase regulator activity 10/1250 107/18639 0.0934579439252336 1.39357009345794 0.180328109946994 0.689055651810374 GO:0030246 carbohydrate binding 23/1250 280/18639 0.0821428571428571 1.22484857142857 0.183073602189472 0.689055651810374 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 8/1250 82/18639 0.0975609756097561 1.4547512195122 0.183419459630633 0.689055651810374 GO:0033549 MAP kinase phosphatase activity 8/1250 82/18639 0.0975609756097561 1.4547512195122 0.183419459630633 0.689055651810374 GO:0140272 exogenous protein binding 8/1250 82/18639 0.0975609756097561 1.4547512195122 0.183419459630633 0.689055651810374 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 28/1250 349/18639 0.0802292263610315 1.19631404011461 0.186225478134358 0.689055651810374 GO:0044389 ubiquitin-like protein ligase binding 26/1250 322/18639 0.0807453416149068 1.2040099378882 0.187885498940732 0.689055651810374 GO:0004032 aldose reductase (NADPH) activity 2/1250 12/18639 0.166666666666667 2.4852 0.190226383121601 0.689055651810374 GO:0004300 enoyl-CoA hydratase activity 2/1250 12/18639 0.166666666666667 2.4852 0.190226383121601 0.689055651810374 GO:0004859 phospholipase inhibitor activity 2/1250 12/18639 0.166666666666667 2.4852 0.190226383121601 0.689055651810374 GO:0005095 GTPase inhibitor activity 2/1250 12/18639 0.166666666666667 2.4852 0.190226383121601 0.689055651810374 GO:0010853 cyclase activator activity 2/1250 12/18639 0.166666666666667 2.4852 0.190226383121601 0.689055651810374 GO:0015368 calcium:monoatomic cation antiporter activity 2/1250 12/18639 0.166666666666667 2.4852 0.190226383121601 0.689055651810374 GO:0016208 AMP binding 2/1250 12/18639 0.166666666666667 2.4852 0.190226383121601 0.689055651810374 GO:0016273 arginine N-methyltransferase activity 2/1250 12/18639 0.166666666666667 2.4852 0.190226383121601 0.689055651810374 GO:0016274 protein-arginine N-methyltransferase activity 2/1250 12/18639 0.166666666666667 2.4852 0.190226383121601 0.689055651810374 GO:0036009 protein-glutamine N-methyltransferase activity 2/1250 12/18639 0.166666666666667 2.4852 0.190226383121601 0.689055651810374 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/1250 12/18639 0.166666666666667 2.4852 0.190226383121601 0.689055651810374 GO:0070008 serine-type exopeptidase activity 2/1250 12/18639 0.166666666666667 2.4852 0.190226383121601 0.689055651810374 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/1250 12/18639 0.166666666666667 2.4852 0.190226383121601 0.689055651810374 GO:0030332 cyclin binding 4/1250 34/18639 0.117647058823529 1.75425882352941 0.191251985727362 0.689055651810374 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 8/1250 83/18639 0.0963855421686747 1.43722409638554 0.191951217290033 0.689055651810374 GO:0008135 translation factor activity, RNA binding 8/1250 83/18639 0.0963855421686747 1.43722409638554 0.191951217290033 0.689055651810374 GO:0030276 clathrin binding 5/1250 46/18639 0.108695652173913 1.62078260869565 0.19334052348082 0.689622249358337 GO:0030291 protein serine/threonine kinase inhibitor activity 5/1250 46/18639 0.108695652173913 1.62078260869565 0.19334052348082 0.689622249358337 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 11/1250 122/18639 0.0901639344262295 1.34445245901639 0.195241861154617 0.694193284105304 GO:0031267 small GTPase binding 23/1250 283/18639 0.0812720848056537 1.21186431095406 0.196659185030119 0.697019896309281 GO:0004602 glutathione peroxidase activity 3/1250 23/18639 0.130434782608696 1.94493913043478 0.197560003456821 0.698003797702335 GO:0017018 myosin phosphatase activity 8/1250 84/18639 0.0952380952380952 1.42011428571429 0.200645145715463 0.703447503665924 GO:0180051 translation factor activity 8/1250 84/18639 0.0952380952380952 1.42011428571429 0.200645145715463 0.703447503665924 GO:0031593 polyubiquitin modification-dependent protein binding 6/1250 59/18639 0.101694915254237 1.51639322033898 0.202116911115161 0.703447503665924 GO:0045309 protein phosphorylated amino acid binding 6/1250 59/18639 0.101694915254237 1.51639322033898 0.202116911115161 0.703447503665924 GO:0030594 neurotransmitter receptor activity 9/1250 97/18639 0.0927835051546392 1.38351340206186 0.202241157303953 0.703447503665924 GO:0043015 gamma-tubulin binding 4/1250 35/18639 0.114285714285714 1.70413714285714 0.20532926018921 0.711977620470324 GO:0043021 ribonucleoprotein complex binding 15/1250 177/18639 0.0847457627118644 1.26366101694915 0.208763962288546 0.720081054752111 GO:0005540 hyaluronic acid binding 3/1250 24/18639 0.125 1.8639 0.215327180989592 0.720081054752111 GO:0060229 lipase activator activity 3/1250 24/18639 0.125 1.8639 0.215327180989592 0.720081054752111 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/1250 13/18639 0.153846153846154 2.29403076923077 0.215381386912462 0.720081054752111 GO:0004535 poly(A)-specific ribonuclease activity 2/1250 13/18639 0.153846153846154 2.29403076923077 0.215381386912462 0.720081054752111 GO:0004993 G protein-coupled serotonin receptor activity 2/1250 13/18639 0.153846153846154 2.29403076923077 0.215381386912462 0.720081054752111 GO:0005542 folic acid binding 2/1250 13/18639 0.153846153846154 2.29403076923077 0.215381386912462 0.720081054752111 GO:0008253 5'-nucleotidase activity 2/1250 13/18639 0.153846153846154 2.29403076923077 0.215381386912462 0.720081054752111 GO:0019855 calcium channel inhibitor activity 2/1250 13/18639 0.153846153846154 2.29403076923077 0.215381386912462 0.720081054752111 GO:0031432 titin binding 2/1250 13/18639 0.153846153846154 2.29403076923077 0.215381386912462 0.720081054752111 GO:0031994 insulin-like growth factor I binding 2/1250 13/18639 0.153846153846154 2.29403076923077 0.215381386912462 0.720081054752111 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/1250 13/18639 0.153846153846154 2.29403076923077 0.215381386912462 0.720081054752111 GO:0043539 protein serine/threonine kinase activator activity 7/1250 73/18639 0.0958904109589041 1.42984109589041 0.216756562592207 0.722521875307358 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 8/1250 86/18639 0.0930232558139535 1.38708837209302 0.218492673072604 0.726147756205685 GO:0070851 growth factor receptor binding 12/1250 139/18639 0.0863309352517986 1.28729784172662 0.222439696788996 0.737078285217975 GO:0048029 monosaccharide binding 7/1250 74/18639 0.0945945945945946 1.41051891891892 0.22668658981568 0.748935045998707 GO:0004713 protein tyrosine kinase activity 12/1250 140/18639 0.0857142857142857 1.27810285714286 0.229606945829353 0.755520291618964 GO:0060590 ATPase regulator activity 5/1250 49/18639 0.102040816326531 1.52155102040816 0.230028945930417 0.755520291618964 GO:0042826 histone deacetylase binding 11/1250 127/18639 0.0866141732283465 1.29152125984252 0.232097699447238 0.759943281586042 GO:0000030 mannosyltransferase activity 3/1250 25/18639 0.12 1.789344 0.233411150772856 0.759943281586042 GO:0008139 nuclear localization sequence binding 3/1250 25/18639 0.12 1.789344 0.233411150772856 0.759943281586042 GO:0004197 cysteine-type endopeptidase activity 8/1250 88/18639 0.0909090909090909 1.35556363636364 0.236906273945095 0.764032659467263 GO:0005545 1-phosphatidylinositol binding 2/1250 14/18639 0.142857142857143 2.13017142857143 0.240806722135664 0.764032659467263 GO:0019992 diacylglycerol binding 2/1250 14/18639 0.142857142857143 2.13017142857143 0.240806722135664 0.764032659467263 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/1250 14/18639 0.142857142857143 2.13017142857143 0.240806722135664 0.764032659467263 GO:0031404 chloride ion binding 2/1250 14/18639 0.142857142857143 2.13017142857143 0.240806722135664 0.764032659467263 GO:0042043 neurexin family protein binding 2/1250 14/18639 0.142857142857143 2.13017142857143 0.240806722135664 0.764032659467263 GO:0042813 Wnt receptor activity 2/1250 14/18639 0.142857142857143 2.13017142857143 0.240806722135664 0.764032659467263 GO:0044548 S100 protein binding 2/1250 14/18639 0.142857142857143 2.13017142857143 0.240806722135664 0.764032659467263 GO:0070742 C2H2 zinc finger domain binding 2/1250 14/18639 0.142857142857143 2.13017142857143 0.240806722135664 0.764032659467263 GO:0015171 amino acid transmembrane transporter activity 9/1250 102/18639 0.0882352941176471 1.31569411764706 0.244669666446356 0.774096119830278 GO:0043531 ADP binding 4/1250 38/18639 0.105263157894737 1.5696 0.249163647040879 0.783224713103871 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/1250 26/18639 0.115384615384615 1.72052307692308 0.25175080064053 0.783224713103871 GO:0030247 polysaccharide binding 3/1250 26/18639 0.115384615384615 1.72052307692308 0.25175080064053 0.783224713103871 GO:0034237 protein kinase A regulatory subunit binding 3/1250 26/18639 0.115384615384615 1.72052307692308 0.25175080064053 0.783224713103871 GO:0043548 phosphatidylinositol 3-kinase binding 3/1250 26/18639 0.115384615384615 1.72052307692308 0.25175080064053 0.783224713103871 GO:0050681 nuclear androgen receptor binding 3/1250 26/18639 0.115384615384615 1.72052307692308 0.25175080064053 0.783224713103871 GO:0005048 signal sequence binding 5/1250 51/18639 0.0980392156862745 1.46188235294118 0.255514566913816 0.792732174358653 GO:0019903 protein phosphatase binding 12/1250 144/18639 0.0833333333333333 1.2426 0.259148391662107 0.801305446474242 GO:1901981 phosphatidylinositol phosphate binding 15/1250 185/18639 0.0810810810810811 1.20901621621622 0.259708818812634 0.801305446474242 GO:0000774 adenyl-nucleotide exchange factor activity 2/1250 15/18639 0.133333333333333 1.98816 0.266353132883956 0.808443113360517 GO:0004559 alpha-mannosidase activity 2/1250 15/18639 0.133333333333333 1.98816 0.266353132883956 0.808443113360517 GO:0008252 nucleotidase activity 2/1250 15/18639 0.133333333333333 1.98816 0.266353132883956 0.808443113360517 GO:0031005 filamin binding 2/1250 15/18639 0.133333333333333 1.98816 0.266353132883956 0.808443113360517 GO:0050780 dopamine receptor binding 2/1250 15/18639 0.133333333333333 1.98816 0.266353132883956 0.808443113360517 GO:0061578 K63-linked deubiquitinase activity 2/1250 15/18639 0.133333333333333 1.98816 0.266353132883956 0.808443113360517 GO:0120013 lipid transfer activity 6/1250 65/18639 0.0923076923076923 1.37641846153846 0.269129203607887 0.808473386703969 GO:0001671 ATPase activator activity 3/1250 27/18639 0.111111111111111 1.6568 0.270287677531352 0.808473386703969 GO:0004364 glutathione transferase activity 3/1250 27/18639 0.111111111111111 1.6568 0.270287677531352 0.808473386703969 GO:0005104 fibroblast growth factor receptor binding 3/1250 27/18639 0.111111111111111 1.6568 0.270287677531352 0.808473386703969 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 3/1250 27/18639 0.111111111111111 1.6568 0.270287677531352 0.808473386703969 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 11/1250 132/18639 0.0833333333333333 1.2426 0.271378306752575 0.808473386703969 GO:0035091 phosphatidylinositol binding 22/1250 284/18639 0.0774647887323944 1.15509295774648 0.271416065536332 0.808473386703969 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4/1250 40/18639 0.1 1.49112 0.27940404588701 0.824868613344923 GO:0050997 quaternary ammonium group binding 4/1250 40/18639 0.1 1.49112 0.27940404588701 0.824868613344923 GO:0071855 neuropeptide receptor binding 4/1250 40/18639 0.1 1.49112 0.27940404588701 0.824868613344923 GO:0046943 carboxylic acid transmembrane transporter activity 15/1250 188/18639 0.0797872340425532 1.18972340425532 0.279908096388809 0.824868613344923 GO:0000149 SNARE binding 9/1250 106/18639 0.0849056603773585 1.26604528301887 0.280602626503943 0.824868613344923 GO:0016860 intramolecular oxidoreductase activity 5/1250 53/18639 0.0943396226415094 1.40671698113208 0.281638183324711 0.825745458962503 GO:0005342 organic acid transmembrane transporter activity 15/1250 189/18639 0.0793650793650794 1.18342857142857 0.286755052014515 0.838552632522863 GO:0051019 mitogen-activated protein kinase binding 3/1250 28/18639 0.107142857142857 1.59762857142857 0.288966180464183 0.842544221035467 GO:0005159 insulin-like growth factor receptor binding 2/1250 16/18639 0.125 1.8639 0.291890137737275 0.842544221035467 GO:0015923 mannosidase activity 2/1250 16/18639 0.125 1.8639 0.291890137737275 0.842544221035467 GO:0055102 lipase inhibitor activity 2/1250 16/18639 0.125 1.8639 0.291890137737275 0.842544221035467 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 2/1250 16/18639 0.125 1.8639 0.291890137737275 0.842544221035467 GO:0015108 chloride transmembrane transporter activity 10/1250 121/18639 0.0826446280991736 1.2323305785124 0.293320552679362 0.842544221035467 GO:0003925 G protein activity 5/1250 54/18639 0.0925925925925926 1.38066666666667 0.294890477362413 0.842544221035467 GO:0017069 snRNA binding 5/1250 54/18639 0.0925925925925926 1.38066666666667 0.294890477362413 0.842544221035467 GO:0051287 NAD binding 5/1250 54/18639 0.0925925925925926 1.38066666666667 0.294890477362413 0.842544221035467 GO:0030971 receptor tyrosine kinase binding 7/1250 81/18639 0.0864197530864197 1.28862222222222 0.299918557176026 0.854729730374425 GO:0030695 GTPase regulator activity 36/1250 489/18639 0.0736196319018405 1.09775705521472 0.303441783031547 0.862575626891708 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/1250 29/18639 0.103448275862069 1.54253793103448 0.307733697395689 0.870594384388382 GO:0060589 nucleoside-triphosphatase regulator activity 36/1250 490/18639 0.073469387755102 1.09551673469388 0.307817300194464 0.870594384388382 GO:0008307 structural constituent of muscle 4/1250 42/18639 0.0952380952380952 1.42011428571429 0.310171607789143 0.870657144671279 GO:0042056 chemoattractant activity 4/1250 42/18639 0.0952380952380952 1.42011428571429 0.310171607789143 0.870657144671279 GO:0051879 Hsp90 protein binding 4/1250 42/18639 0.0952380952380952 1.42011428571429 0.310171607789143 0.870657144671279 GO:0098960 postsynaptic neurotransmitter receptor activity 6/1250 69/18639 0.0869565217391304 1.29662608695652 0.316475788691701 0.873171224740629 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/1250 17/18639 0.117647058823529 1.75425882352941 0.317304186133425 0.873171224740629 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 2/1250 17/18639 0.117647058823529 1.75425882352941 0.317304186133425 0.873171224740629 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/1250 17/18639 0.117647058823529 1.75425882352941 0.317304186133425 0.873171224740629 GO:0016805 dipeptidase activity 2/1250 17/18639 0.117647058823529 1.75425882352941 0.317304186133425 0.873171224740629 GO:0045236 CXCR chemokine receptor binding 2/1250 17/18639 0.117647058823529 1.75425882352941 0.317304186133425 0.873171224740629 GO:0051787 misfolded protein binding 2/1250 17/18639 0.117647058823529 1.75425882352941 0.317304186133425 0.873171224740629 GO:0070492 oligosaccharide binding 2/1250 17/18639 0.117647058823529 1.75425882352941 0.317304186133425 0.873171224740629 GO:0170055 lipid transmembrane transporter activity 5/1250 56/18639 0.0892857142857143 1.33135714285714 0.321680438706766 0.881041975558467 GO:0005254 chloride channel activity 7/1250 83/18639 0.0843373493975904 1.25757108433735 0.321737650003047 0.881041975558467 GO:0008200 ion channel inhibitor activity 4/1250 43/18639 0.0930232558139535 1.38708837209302 0.325680071355859 0.881266450816285 GO:0001968 fibronectin binding 3/1250 30/18639 0.1 1.49112 0.326540693829249 0.881266450816285 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/1250 30/18639 0.1 1.49112 0.326540693829249 0.881266450816285 GO:0031210 phosphatidylcholine binding 3/1250 30/18639 0.1 1.49112 0.326540693829249 0.881266450816285 GO:0048019 receptor antagonist activity 3/1250 30/18639 0.1 1.49112 0.326540693829249 0.881266450816285 GO:0070566 adenylyltransferase activity 3/1250 30/18639 0.1 1.49112 0.326540693829249 0.881266450816285 GO:0008028 monocarboxylic acid transmembrane transporter activity 6/1250 70/18639 0.0857142857142857 1.27810285714286 0.328522565445321 0.884483830045094 GO:0005506 iron ion binding 12/1250 154/18639 0.0779220779220779 1.16191168831169 0.337857421399294 0.90258026952449 GO:0140299 molecular sensor activity 6/1250 71/18639 0.0845070422535211 1.2601014084507 0.34062688199271 0.90258026952449 GO:0001223 transcription coactivator binding 4/1250 44/18639 0.0909090909090909 1.35556363636364 0.341234611638645 0.90258026952449 GO:0016248 channel inhibitor activity 4/1250 44/18639 0.0909090909090909 1.35556363636364 0.341234611638645 0.90258026952449 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/1250 18/18639 0.111111111111111 1.6568 0.342496977274918 0.90258026952449 GO:0008525 phosphatidylcholine transporter activity 2/1250 18/18639 0.111111111111111 1.6568 0.342496977274918 0.90258026952449 GO:0017075 syntaxin-1 binding 2/1250 18/18639 0.111111111111111 1.6568 0.342496977274918 0.90258026952449 GO:0035615 clathrin adaptor activity 2/1250 18/18639 0.111111111111111 1.6568 0.342496977274918 0.90258026952449 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 2/1250 18/18639 0.111111111111111 1.6568 0.342496977274918 0.90258026952449 GO:0030414 peptidase inhibitor activity 13/1250 169/18639 0.0769230769230769 1.14701538461538 0.345244147064748 0.903695447150743 GO:0005164 tumor necrosis factor receptor binding 3/1250 31/18639 0.0967741935483871 1.44301935483871 0.345340760161177 0.903695447150743 GO:0047499 calcium-independent phospholipase A2 activity 3/1250 31/18639 0.0967741935483871 1.44301935483871 0.345340760161177 0.903695447150743 GO:0008514 organic anion transmembrane transporter activity 20/1250 269/18639 0.0743494423791822 1.10863940520446 0.34890979825728 0.910906699412945 GO:0141108 transporter regulator activity 13/1250 170/18639 0.0764705882352941 1.14026823529412 0.353070926927665 0.919626600369733 GO:0001653 peptide receptor activity 10/1250 128/18639 0.078125 1.1649375 0.355784555369151 0.92079679597923 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 10/1250 128/18639 0.078125 1.1649375 0.355784555369151 0.92079679597923 GO:0046915 transition metal ion transmembrane transporter activity 4/1250 45/18639 0.0888888888888889 1.32544 0.356808758441952 0.92079679597923 GO:0141110 transporter inhibitor activity 4/1250 45/18639 0.0888888888888889 1.32544 0.356808758441952 0.92079679597923 GO:0031369 translation initiation factor binding 3/1250 32/18639 0.09375 1.397925 0.364090623955849 0.924651684180387 GO:0042910 xenobiotic transmembrane transporter activity 3/1250 32/18639 0.09375 1.397925 0.364090623955849 0.924651684180387 GO:0047498 calcium-dependent phospholipase A2 activity 3/1250 32/18639 0.09375 1.397925 0.364090623955849 0.924651684180387 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/1250 19/18639 0.105263157894737 1.5696 0.367383928089529 0.924651684180387 GO:0005229 intracellularly calcium-gated chloride channel activity 2/1250 19/18639 0.105263157894737 1.5696 0.367383928089529 0.924651684180387 GO:0005520 insulin-like growth factor binding 2/1250 19/18639 0.105263157894737 1.5696 0.367383928089529 0.924651684180387 GO:0022821 solute:potassium antiporter activity 2/1250 19/18639 0.105263157894737 1.5696 0.367383928089529 0.924651684180387 GO:0030506 ankyrin binding 2/1250 19/18639 0.105263157894737 1.5696 0.367383928089529 0.924651684180387 GO:0042834 peptidoglycan binding 2/1250 19/18639 0.105263157894737 1.5696 0.367383928089529 0.924651684180387 GO:0046624 sphingolipid transporter activity 2/1250 19/18639 0.105263157894737 1.5696 0.367383928089529 0.924651684180387 GO:0141147 intracellularly calcium-gated channel activity 2/1250 19/18639 0.105263157894737 1.5696 0.367383928089529 0.924651684180387 GO:0004180 carboxypeptidase activity 4/1250 46/18639 0.0869565217391304 1.29662608695652 0.372377161771583 0.933025550747591 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 4/1250 46/18639 0.0869565217391304 1.29662608695652 0.372377161771583 0.933025550747591 GO:0031625 ubiquitin protein ligase binding 22/1250 302/18639 0.0728476821192053 1.08624635761589 0.374968724524489 0.937421811311223 GO:0140030 modification-dependent protein binding 13/1250 173/18639 0.0751445086705202 1.12049479768786 0.376720077043034 0.939702642067257 GO:0019956 chemokine binding 3/1250 33/18639 0.0909090909090909 1.35556363636364 0.382750132626809 0.950510307188528 GO:0140311 protein sequestering activity 3/1250 33/18639 0.0909090909090909 1.35556363636364 0.382750132626809 0.950510307188528 GO:0099106 ion channel regulator activity 12/1250 160/18639 0.075 1.11834 0.387197160211779 0.959085015078362 GO:0140938 histone H3 methyltransferase activity 4/1250 47/18639 0.0851063829787234 1.26903829787234 0.387915635562944 0.959085015078362 GO:0019003 GDP binding 6/1250 75/18639 0.08 1.192896 0.389364550890846 0.960546909686668 GO:0001972 retinoic acid binding 2/1250 20/18639 0.1 1.49112 0.391892777837342 0.961457609302355 GO:0005326 neurotransmitter transmembrane transporter activity 2/1250 20/18639 0.1 1.49112 0.391892777837342 0.961457609302355 GO:0005179 hormone activity 10/1250 132/18639 0.0757575757575758 1.12963636363636 0.392309042367122 0.961457609302355 GO:0004866 endopeptidase inhibitor activity 12/1250 161/18639 0.0745341614906832 1.11139378881988 0.395497627816102 0.967155771078678 GO:0051536 iron-sulfur cluster binding 6/1250 76/18639 0.0789473684210526 1.1772 0.401567663506674 0.976960024766485 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 7/1250 91/18639 0.0769230769230769 1.14701538461538 0.410737218788324 0.976960024766485 GO:0051540 metal cluster binding 6/1250 77/18639 0.0779220779220779 1.16191168831169 0.413754767310705 0.976960024766485 GO:0005123 death receptor binding 2/1250 21/18639 0.0952380952380952 1.42011428571429 0.415962317948844 0.976960024766485 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/1250 21/18639 0.0952380952380952 1.42011428571429 0.415962317948844 0.976960024766485 GO:0015125 bile acid transmembrane transporter activity 2/1250 21/18639 0.0952380952380952 1.42011428571429 0.415962317948844 0.976960024766485 GO:0140312 cargo adaptor activity 2/1250 21/18639 0.0952380952380952 1.42011428571429 0.415962317948844 0.976960024766485 GO:1904047 S-adenosyl-L-methionine binding 2/1250 21/18639 0.0952380952380952 1.42011428571429 0.415962317948844 0.976960024766485 GO:0000175 3'-5'-RNA exonuclease activity 3/1250 35/18639 0.0857142857142857 1.27810285714286 0.419652800531183 0.976960024766485 GO:0004623 phospholipase A2 activity 3/1250 35/18639 0.0857142857142857 1.27810285714286 0.419652800531183 0.976960024766485 GO:0005154 epidermal growth factor receptor binding 3/1250 35/18639 0.0857142857142857 1.27810285714286 0.419652800531183 0.976960024766485 GO:0043178 alcohol binding 7/1250 92/18639 0.0760869565217391 1.13454782608696 0.421899511972616 0.976960024766485 GO:0004540 RNA nuclease activity 9/1250 121/18639 0.0743801652892562 1.10909752066116 0.423991469685752 0.976960024766485 GO:0016853 isomerase activity 13/1250 180/18639 0.0722222222222222 1.07692 0.432451936264451 0.976960024766485 GO:0008528 G protein-coupled peptide receptor activity 9/1250 122/18639 0.0737704918032787 1.10000655737705 0.433701425604306 0.976960024766485 GO:0032813 tumor necrosis factor receptor superfamily binding 4/1250 50/18639 0.08 1.192896 0.434127697468869 0.976960024766485 GO:0004033 aldo-keto reductase (NADPH) activity 3/1250 36/18639 0.0833333333333333 1.2426 0.437830776380539 0.976960024766485 GO:0005484 SNAP receptor activity 3/1250 36/18639 0.0833333333333333 1.2426 0.437830776380539 0.976960024766485 GO:0045505 dynein intermediate chain binding 3/1250 36/18639 0.0833333333333333 1.2426 0.437830776380539 0.976960024766485 GO:0046332 SMAD binding 6/1250 79/18639 0.0759493670886076 1.13249620253165 0.438036727683199 0.976960024766485 GO:0016922 nuclear receptor binding 10/1250 137/18639 0.072992700729927 1.08840875912409 0.438189807171537 0.976960024766485 GO:0005496 steroid binding 8/1250 108/18639 0.0740740740740741 1.10453333333333 0.438718982204912 0.976960024766485 GO:0004407 histone deacetylase activity 2/1250 22/18639 0.0909090909090909 1.35556363636364 0.439541236593362 0.976960024766485 GO:0008970 phospholipase A1 activity 2/1250 22/18639 0.0909090909090909 1.35556363636364 0.439541236593362 0.976960024766485 GO:0033558 protein lysine deacetylase activity 2/1250 22/18639 0.0909090909090909 1.35556363636364 0.439541236593362 0.976960024766485 GO:0005272 sodium channel activity 4/1250 51/18639 0.0784313725490196 1.16950588235294 0.449328814962915 0.976960024766485 GO:0016830 carbon-carbon lyase activity 4/1250 51/18639 0.0784313725490196 1.16950588235294 0.449328814962915 0.976960024766485 GO:0016247 channel regulator activity 12/1250 168/18639 0.0714285714285714 1.06508571428571 0.453722308915275 0.976960024766485 GO:0019213 deacetylase activity 3/1250 37/18639 0.0810810810810811 1.20901621621622 0.455787858189437 0.976960024766485 GO:0042805 actinin binding 3/1250 37/18639 0.0810810810810811 1.20901621621622 0.455787858189437 0.976960024766485 GO:0016493 C-C chemokine receptor activity 2/1250 23/18639 0.0869565217391304 1.29662608695652 0.462587068320651 0.976960024766485 GO:0016849 phosphorus-oxygen lyase activity 2/1250 23/18639 0.0869565217391304 1.29662608695652 0.462587068320651 0.976960024766485 GO:1902936 phosphatidylinositol bisphosphate binding 8/1250 111/18639 0.0720720720720721 1.07468108108108 0.469573435838109 0.976960024766485 GO:0042054 histone methyltransferase activity 5/1250 67/18639 0.0746268656716418 1.11277611940299 0.470005375137616 0.976960024766485 GO:0000146 microfilament motor activity 3/1250 38/18639 0.0789473684210526 1.1772 0.473498504859313 0.976960024766485 GO:0005501 retinoid binding 3/1250 38/18639 0.0789473684210526 1.1772 0.473498504859313 0.976960024766485 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 3/1250 38/18639 0.0789473684210526 1.1772 0.473498504859313 0.976960024766485 GO:0019840 isoprenoid binding 3/1250 38/18639 0.0789473684210526 1.1772 0.473498504859313 0.976960024766485 GO:0005246 calcium channel regulator activity 4/1250 53/18639 0.0754716981132075 1.12537358490566 0.479316463408766 0.976960024766485 GO:0051018 protein kinase A binding 4/1250 53/18639 0.0754716981132075 1.12537358490566 0.479316463408766 0.976960024766485 GO:0043022 ribosome binding 8/1250 112/18639 0.0714285714285714 1.06508571428571 0.479779647607225 0.976960024766485 GO:0001091 RNA polymerase II general transcription initiation factor binding 2/1250 24/18639 0.0833333333333333 1.2426 0.485065239896203 0.976960024766485 GO:0004622 lysophospholipase activity 2/1250 24/18639 0.0833333333333333 1.2426 0.485065239896203 0.976960024766485 GO:0019957 C-C chemokine binding 2/1250 24/18639 0.0833333333333333 1.2426 0.485065239896203 0.976960024766485 GO:0030215 semaphorin receptor binding 2/1250 24/18639 0.0833333333333333 1.2426 0.485065239896203 0.976960024766485 GO:0030165 PDZ domain binding 6/1250 83/18639 0.072289156626506 1.07791807228916 0.485943475022077 0.976960024766485 GO:0015485 cholesterol binding 4/1250 54/18639 0.0740740740740741 1.10453333333333 0.494070542292474 0.976960024766485 GO:0050661 NADP binding 4/1250 54/18639 0.0740740740740741 1.10453333333333 0.494070542292474 0.976960024766485 GO:0016279 protein-lysine N-methyltransferase activity 5/1250 69/18639 0.072463768115942 1.08052173913043 0.496161446775805 0.976960024766485 GO:0001094 TFIID-class transcription factor complex binding 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0003796 lysozyme activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0004090 carbonyl reductase (NADPH) activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0004935 adrenergic receptor activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0004955 prostaglandin receptor activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0005131 growth hormone receptor binding 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0008190 eukaryotic initiation factor 4E binding 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0008239 dipeptidyl-peptidase activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0008519 ammonium channel activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0015203 polyamine transmembrane transporter activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0016427 tRNA (cytidine) methyltransferase activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0016868 intramolecular phosphotransferase activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0019911 structural constituent of myelin sheath 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0030957 Tat protein binding 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0032052 bile acid binding 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0032356 oxidized DNA binding 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0042166 acetylcholine binding 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0043208 glycosphingolipid binding 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0051378 serotonin binding 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0051864 histone H3K36 demethylase activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0070513 death domain binding 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0098505 G-rich strand telomeric DNA binding 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0141109 transporter activator activity 1/1250 10/18639 0.1 1.49112 0.500604536405151 0.976960024766485 GO:0005251 delayed rectifier potassium channel activity 2/1250 25/18639 0.08 1.192896 0.506948204167798 0.976960024766485 GO:0005537 D-mannose binding 2/1250 25/18639 0.08 1.192896 0.506948204167798 0.976960024766485 GO:0017056 structural constituent of nuclear pore 2/1250 25/18639 0.08 1.192896 0.506948204167798 0.976960024766485 GO:0004532 RNA exonuclease activity 3/1250 40/18639 0.075 1.11834 0.508091351271187 0.976960024766485 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/1250 40/18639 0.075 1.11834 0.508091351271187 0.976960024766485 GO:0140662 ATP-dependent protein folding chaperone 3/1250 40/18639 0.075 1.11834 0.508091351271187 0.976960024766485 GO:0046982 protein heterodimerization activity 25/1250 369/18639 0.0677506775067751 1.01024390243902 0.508996028734408 0.976960024766485 GO:0016278 lysine N-methyltransferase activity 5/1250 70/18639 0.0714285714285714 1.06508571428571 0.509056745339689 0.976960024766485 GO:0001221 transcription coregulator binding 8/1250 115/18639 0.0695652173913043 1.03730086956522 0.510079072373521 0.976960024766485 GO:0017124 SH3 domain binding 8/1250 115/18639 0.0695652173913043 1.03730086956522 0.510079072373521 0.976960024766485 GO:0019212 phosphatase inhibitor activity 4/1250 56/18639 0.0714285714285714 1.06508571428571 0.523027061420334 0.976960024766485 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 4/1250 56/18639 0.0714285714285714 1.06508571428571 0.523027061420334 0.976960024766485 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 3/1250 41/18639 0.0731707317073171 1.09106341463415 0.52493513513206 0.976960024766485 GO:0017080 sodium channel regulator activity 3/1250 41/18639 0.0731707317073171 1.09106341463415 0.52493513513206 0.976960024766485 GO:0061650 ubiquitin-like protein conjugating enzyme activity 3/1250 41/18639 0.0731707317073171 1.09106341463415 0.52493513513206 0.976960024766485 GO:0140828 metal cation:monoatomic cation antiporter activity 3/1250 41/18639 0.0731707317073171 1.09106341463415 0.52493513513206 0.976960024766485 GO:0005516 calmodulin binding 14/1250 207/18639 0.0676328502415459 1.00848695652174 0.526802330083602 0.976960024766485 GO:0001637 G protein-coupled chemoattractant receptor activity 2/1250 26/18639 0.0769230769230769 1.14701538461538 0.528214654461737 0.976960024766485 GO:0004435 phosphatidylinositol phospholipase C activity 2/1250 26/18639 0.0769230769230769 1.14701538461538 0.528214654461737 0.976960024766485 GO:0004950 chemokine receptor activity 2/1250 26/18639 0.0769230769230769 1.14701538461538 0.528214654461737 0.976960024766485 GO:0005160 transforming growth factor beta receptor binding 2/1250 26/18639 0.0769230769230769 1.14701538461538 0.528214654461737 0.976960024766485 GO:0008157 protein phosphatase 1 binding 2/1250 26/18639 0.0769230769230769 1.14701538461538 0.528214654461737 0.976960024766485 GO:0051139 metal cation:proton antiporter activity 2/1250 26/18639 0.0769230769230769 1.14701538461538 0.528214654461737 0.976960024766485 GO:0070006 metalloaminopeptidase activity 2/1250 26/18639 0.0769230769230769 1.14701538461538 0.528214654461737 0.976960024766485 GO:0070412 R-SMAD binding 2/1250 26/18639 0.0769230769230769 1.14701538461538 0.528214654461737 0.976960024766485 GO:0000099 sulfur amino acid transmembrane transporter activity 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0002162 dystroglycan binding 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0003953 NAD+ nucleosidase activity 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0004016 adenylate cyclase activity 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0004954 prostanoid receptor activity 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0005114 type II transforming growth factor beta receptor binding 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0005225 volume-sensitive anion channel activity 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0008172 S-methyltransferase activity 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0008271 secondary active sulfate transmembrane transporter activity 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0008432 JUN kinase binding 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0008503 benzodiazepine receptor activity 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0008526 phosphatidylinositol transfer activity 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0016594 glycine binding 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0019107 myristoyltransferase activity 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0019215 intermediate filament binding 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0034056 estrogen response element binding 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0034713 type I transforming growth factor beta receptor binding 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0035252 UDP-xylosyltransferase activity 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0042285 xylosyltransferase activity 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0042608 T cell receptor binding 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0048185 activin binding 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0050998 nitric-oxide synthase binding 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0070990 snRNP binding 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/1250 11/18639 0.0909090909090909 1.35556363636364 0.534113813848576 0.976960024766485 GO:0005319 lipid transporter activity 12/1250 178/18639 0.0674157303370786 1.00524943820225 0.535471156152794 0.976960024766485 GO:0016859 cis-trans isomerase activity 3/1250 42/18639 0.0714285714285714 1.06508571428571 0.54145540646613 0.976960024766485 GO:0005253 monoatomic anion channel activity 7/1250 103/18639 0.0679611650485437 1.01338252427184 0.541560959997587 0.976960024766485 GO:0008509 monoatomic anion transmembrane transporter activity 10/1250 149/18639 0.0671140939597315 1.00075167785235 0.545945389227642 0.976960024766485 GO:0004521 RNA endonuclease activity 5/1250 73/18639 0.0684931506849315 1.02131506849315 0.546892959372829 0.976960024766485 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/1250 27/18639 0.0740740740740741 1.10453333333333 0.548848812616168 0.976960024766485 GO:0023026 MHC class II protein complex binding 2/1250 27/18639 0.0740740740740741 1.10453333333333 0.548848812616168 0.976960024766485 GO:0035255 ionotropic glutamate receptor binding 2/1250 27/18639 0.0740740740740741 1.10453333333333 0.548848812616168 0.976960024766485 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/1250 27/18639 0.0740740740740741 1.10453333333333 0.548848812616168 0.976960024766485 GO:0061980 regulatory RNA binding 4/1250 58/18639 0.0689655172413793 1.02835862068966 0.551165379466673 0.976960024766485 GO:0003684 damaged DNA binding 5/1250 74/18639 0.0675675675675676 1.00751351351351 0.559192671715663 0.976960024766485 GO:0004879 nuclear receptor activity 4/1250 59/18639 0.0677966101694915 1.01092881355932 0.564900870778637 0.976960024766485 GO:0070888 E-box binding 4/1250 59/18639 0.0677966101694915 1.01092881355932 0.564900870778637 0.976960024766485 GO:0000340 RNA 7-methylguanosine cap binding 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0003720 telomerase activity 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0003995 acyl-CoA dehydrogenase activity 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0005165 neurotrophin receptor binding 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0005247 voltage-gated chloride channel activity 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0008179 adenylate cyclase binding 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0008504 monoamine transmembrane transporter activity 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0008603 cAMP-dependent protein kinase regulator activity 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0015132 prostaglandin transmembrane transporter activity 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0015269 calcium-activated potassium channel activity 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0016801 hydrolase activity, acting on ether bonds 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0016803 ether hydrolase activity 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0017166 vinculin binding 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0031543 peptidyl-proline dioxygenase activity 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0034452 dynactin binding 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0035197 siRNA binding 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0035259 nuclear glucocorticoid receptor binding 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0035497 cAMP response element binding 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0042301 phosphate ion binding 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0043047 single-stranded telomeric DNA binding 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0070410 co-SMAD binding 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0140900 chloride:bicarbonate antiporter activity 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:1990459 transferrin receptor binding 1/1250 12/18639 0.0833333333333333 1.2426 0.565376307551028 0.976960024766485 GO:0016866 intramolecular transferase activity 2/1250 28/18639 0.0714285714285714 1.06508571428571 0.568839784320166 0.976960024766485 GO:0019789 SUMO transferase activity 2/1250 28/18639 0.0714285714285714 1.06508571428571 0.568839784320166 0.976960024766485 GO:0045499 chemorepellent activity 2/1250 28/18639 0.0714285714285714 1.06508571428571 0.568839784320166 0.976960024766485 GO:0046625 sphingolipid binding 2/1250 28/18639 0.0714285714285714 1.06508571428571 0.568839784320166 0.976960024766485 GO:0051393 alpha-actinin binding 2/1250 28/18639 0.0714285714285714 1.06508571428571 0.568839784320166 0.976960024766485 GO:0051537 2 iron, 2 sulfur cluster binding 2/1250 28/18639 0.0714285714285714 1.06508571428571 0.568839784320166 0.976960024766485 GO:0051959 dynein light intermediate chain binding 2/1250 28/18639 0.0714285714285714 1.06508571428571 0.568839784320166 0.976960024766485 GO:0097718 disordered domain specific binding 2/1250 28/18639 0.0714285714285714 1.06508571428571 0.568839784320166 0.976960024766485 GO:0008013 beta-catenin binding 7/1250 106/18639 0.0660377358490566 0.984701886792453 0.572483393304125 0.976960024766485 GO:0016790 thiolester hydrolase activity 3/1250 44/18639 0.0681818181818182 1.01667272727273 0.573472991596529 0.976960024766485 GO:0001098 basal transcription machinery binding 4/1250 60/18639 0.0666666666666667 0.99408 0.578401725554984 0.976960024766485 GO:0001099 basal RNA polymerase II transcription machinery binding 4/1250 60/18639 0.0666666666666667 0.99408 0.578401725554984 0.976960024766485 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 4/1250 60/18639 0.0666666666666667 0.99408 0.578401725554984 0.976960024766485 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4/1250 60/18639 0.0666666666666667 0.99408 0.578401725554984 0.976960024766485 GO:0098531 ligand-modulated transcription factor activity 4/1250 60/18639 0.0666666666666667 0.99408 0.578401725554984 0.976960024766485 GO:0008237 metallopeptidase activity 12/1250 184/18639 0.0652173913043478 0.972469565217391 0.582560388125788 0.976960024766485 GO:0008017 microtubule binding 18/1250 276/18639 0.0652173913043478 0.972469565217391 0.584053886020036 0.976960024766485 GO:0016829 lyase activity 13/1250 200/18639 0.065 0.969228 0.587493901057313 0.976960024766485 GO:0004181 metallocarboxypeptidase activity 2/1250 29/18639 0.0689655172413793 1.02835862068966 0.588180975944202 0.976960024766485 GO:0004629 phospholipase C activity 2/1250 29/18639 0.0689655172413793 1.02835862068966 0.588180975944202 0.976960024766485 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 2/1250 29/18639 0.0689655172413793 1.02835862068966 0.588180975944202 0.976960024766485 GO:0097472 cyclin-dependent protein kinase activity 2/1250 29/18639 0.0689655172413793 1.02835862068966 0.588180975944202 0.976960024766485 GO:0004715 non-membrane spanning protein tyrosine kinase activity 3/1250 45/18639 0.0666666666666667 0.99408 0.588949008250428 0.976960024766485 GO:0051539 4 iron, 4 sulfur cluster binding 3/1250 45/18639 0.0666666666666667 0.99408 0.588949008250428 0.976960024766485 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 4/1250 61/18639 0.0655737704918033 0.977783606557377 0.591660062830993 0.976960024766485 GO:0003964 RNA-directed DNA polymerase activity 1/1250 13/18639 0.0769230769230769 1.14701538461538 0.594542550937575 0.976960024766485 GO:0005172 vascular endothelial growth factor receptor binding 1/1250 13/18639 0.0769230769230769 1.14701538461538 0.594542550937575 0.976960024766485 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1250 13/18639 0.0769230769230769 1.14701538461538 0.594542550937575 0.976960024766485 GO:0008417 fucosyltransferase activity 1/1250 13/18639 0.0769230769230769 1.14701538461538 0.594542550937575 0.976960024766485 GO:0009982 pseudouridine synthase activity 1/1250 13/18639 0.0769230769230769 1.14701538461538 0.594542550937575 0.976960024766485 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/1250 13/18639 0.0769230769230769 1.14701538461538 0.594542550937575 0.976960024766485 GO:0017154 semaphorin receptor activity 1/1250 13/18639 0.0769230769230769 1.14701538461538 0.594542550937575 0.976960024766485 GO:0019104 DNA N-glycosylase activity 1/1250 13/18639 0.0769230769230769 1.14701538461538 0.594542550937575 0.976960024766485 GO:0032396 inhibitory MHC class I receptor activity 1/1250 13/18639 0.0769230769230769 1.14701538461538 0.594542550937575 0.976960024766485 GO:0046974 histone H3K9 methyltransferase activity 1/1250 13/18639 0.0769230769230769 1.14701538461538 0.594542550937575 0.976960024766485 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/1250 13/18639 0.0769230769230769 1.14701538461538 0.594542550937575 0.976960024766485 GO:0061459 L-arginine transmembrane transporter activity 1/1250 13/18639 0.0769230769230769 1.14701538461538 0.594542550937575 0.976960024766485 GO:0071714 icosanoid transmembrane transporter activity 1/1250 13/18639 0.0769230769230769 1.14701538461538 0.594542550937575 0.976960024766485 GO:0089720 caspase binding 1/1250 13/18639 0.0769230769230769 1.14701538461538 0.594542550937575 0.976960024766485 GO:1901338 catecholamine binding 1/1250 13/18639 0.0769230769230769 1.14701538461538 0.594542550937575 0.976960024766485 GO:0015631 tubulin binding 25/1250 385/18639 0.0649350649350649 0.96825974025974 0.596729609360797 0.976960024766485 GO:0015276 ligand-gated monoatomic ion channel activity 12/1250 186/18639 0.0645161290322581 0.962012903225806 0.597803047821717 0.976960024766485 GO:0015179 L-amino acid transmembrane transporter activity 4/1250 62/18639 0.0645161290322581 0.962012903225806 0.604668964351269 0.976960024766485 GO:0005216 monoatomic ion channel activity 29/1250 448/18639 0.0647321428571429 0.965233928571429 0.606798714515638 0.976960024766485 GO:0008187 poly-pyrimidine tract binding 2/1250 30/18639 0.0666666666666667 0.99408 0.606869567523841 0.976960024766485 GO:0098918 structural constituent of synapse 2/1250 30/18639 0.0666666666666667 0.99408 0.606869567523841 0.976960024766485 GO:0022834 ligand-gated channel activity 12/1250 188/18639 0.0638297872340425 0.951778723404255 0.612789266963848 0.976960024766485 GO:0003714 transcription corepressor activity 13/1250 204/18639 0.0637254901960784 0.950223529411765 0.616428906799179 0.976960024766485 GO:0022824 transmitter-gated monoatomic ion channel activity 4/1250 63/18639 0.0634920634920635 0.946742857142857 0.617422433767497 0.976960024766485 GO:0022835 transmitter-gated channel activity 4/1250 63/18639 0.0634920634920635 0.946742857142857 0.617422433767497 0.976960024766485 GO:0016835 carbon-oxygen lyase activity 5/1250 79/18639 0.0632911392405063 0.943746835443038 0.618026709059113 0.976960024766485 GO:0099095 ligand-gated monoatomic anion channel activity 3/1250 47/18639 0.0638297872340425 0.951778723404255 0.618795697167025 0.976960024766485 GO:0004867 serine-type endopeptidase inhibitor activity 6/1250 95/18639 0.0631578947368421 0.94176 0.619604441633473 0.976960024766485 GO:0008174 mRNA methyltransferase activity 1/1250 14/18639 0.0714285714285714 1.06508571428571 0.621752999306953 0.976960024766485 GO:0008195 phosphatidate phosphatase activity 1/1250 14/18639 0.0714285714285714 1.06508571428571 0.621752999306953 0.976960024766485 GO:0008474 palmitoyl-(protein) hydrolase activity 1/1250 14/18639 0.0714285714285714 1.06508571428571 0.621752999306953 0.976960024766485 GO:0008494 translation activator activity 1/1250 14/18639 0.0714285714285714 1.06508571428571 0.621752999306953 0.976960024766485 GO:0015386 potassium:proton antiporter activity 1/1250 14/18639 0.0714285714285714 1.06508571428571 0.621752999306953 0.976960024766485 GO:0015926 glucosidase activity 1/1250 14/18639 0.0714285714285714 1.06508571428571 0.621752999306953 0.976960024766485 GO:0032036 myosin heavy chain binding 1/1250 14/18639 0.0714285714285714 1.06508571428571 0.621752999306953 0.976960024766485 GO:0043176 amine binding 1/1250 14/18639 0.0714285714285714 1.06508571428571 0.621752999306953 0.976960024766485 GO:0061783 peptidoglycan muralytic activity 1/1250 14/18639 0.0714285714285714 1.06508571428571 0.621752999306953 0.976960024766485 GO:0098599 palmitoyl hydrolase activity 1/1250 14/18639 0.0714285714285714 1.06508571428571 0.621752999306953 0.976960024766485 GO:0098847 sequence-specific single stranded DNA binding 1/1250 14/18639 0.0714285714285714 1.06508571428571 0.621752999306953 0.976960024766485 GO:0016757 glycosyltransferase activity 17/1250 267/18639 0.0636704119850187 0.949402247191011 0.623776711449326 0.976960024766485 GO:0004519 endonuclease activity 8/1250 127/18639 0.062992125984252 0.939288188976378 0.62410237079716 0.976960024766485 GO:0005184 neuropeptide hormone activity 2/1250 31/18639 0.0645161290322581 0.962012903225806 0.624906036997128 0.976960024766485 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/1250 31/18639 0.0645161290322581 0.962012903225806 0.624906036997128 0.976960024766485 GO:0008327 methyl-CpG binding 2/1250 31/18639 0.0645161290322581 0.962012903225806 0.624906036997128 0.976960024766485 GO:0016411 acylglycerol O-acyltransferase activity 2/1250 31/18639 0.0645161290322581 0.962012903225806 0.624906036997128 0.976960024766485 GO:0070273 phosphatidylinositol-4-phosphate binding 2/1250 31/18639 0.0645161290322581 0.962012903225806 0.624906036997128 0.976960024766485 GO:0004252 serine-type endopeptidase activity 11/1250 176/18639 0.0625 0.93195 0.639539876908367 0.976960024766485 GO:0035591 signaling adaptor activity 8/1250 129/18639 0.062015503875969 0.924725581395349 0.641672408699019 0.976960024766485 GO:0015106 bicarbonate transmembrane transporter activity 2/1250 32/18639 0.0625 0.93195 0.64229373119988 0.976960024766485 GO:0022884 macromolecule transmembrane transporter activity 2/1250 32/18639 0.0625 0.93195 0.64229373119988 0.976960024766485 GO:0030515 snoRNA binding 2/1250 32/18639 0.0625 0.93195 0.64229373119988 0.976960024766485 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/1250 32/18639 0.0625 0.93195 0.64229373119988 0.976960024766485 GO:0160041 neuropeptide activity 2/1250 32/18639 0.0625 0.93195 0.64229373119988 0.976960024766485 GO:0001222 transcription corepressor binding 3/1250 49/18639 0.0612244897959184 0.912930612244898 0.647134240140103 0.976960024766485 GO:0016763 pentosyltransferase activity 3/1250 49/18639 0.0612244897959184 0.912930612244898 0.647134240140103 0.976960024766485 GO:0035254 glutamate receptor binding 3/1250 49/18639 0.0612244897959184 0.912930612244898 0.647134240140103 0.976960024766485 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0004953 icosanoid receptor activity 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0015116 sulfate transmembrane transporter activity 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0015929 hexosaminidase activity 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0016846 carbon-sulfur lyase activity 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0017081 chloride channel regulator activity 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0030553 cGMP binding 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0034483 heparan sulfate sulfotransferase activity 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0050700 CARD domain binding 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0051371 muscle alpha-actinin binding 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0140161 monocarboxylate:sodium symporter activity 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0140776 protein-containing complex destabilizing activity 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0141050 histone H3K deacetylase activity 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0141051 histone H4K deacetylase activity 1/1250 15/18639 0.0666666666666667 0.99408 0.647138704051453 0.976960024766485 GO:0008170 N-methyltransferase activity 6/1250 98/18639 0.0612244897959184 0.912930612244898 0.64978649075553 0.976960024766485 GO:0004518 nuclease activity 13/1250 209/18639 0.062200956937799 0.927490909090909 0.651174526264664 0.976960024766485 GO:0008236 serine-type peptidase activity 12/1250 194/18639 0.0618556701030928 0.922342268041237 0.656060422499131 0.976960024766485 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2/1250 33/18639 0.0606060606060606 0.903709090909091 0.659038479494917 0.976960024766485 GO:0042923 neuropeptide binding 2/1250 33/18639 0.0606060606060606 0.903709090909091 0.659038479494917 0.976960024766485 GO:0140416 transcription regulator inhibitor activity 2/1250 33/18639 0.0606060606060606 0.903709090909091 0.659038479494917 0.976960024766485 GO:0043130 ubiquitin binding 6/1250 100/18639 0.06 0.894672 0.669074807145315 0.976960024766485 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/1250 16/18639 0.0625 0.93195 0.670821941805731 0.976960024766485 GO:0005521 lamin binding 1/1250 16/18639 0.0625 0.93195 0.670821941805731 0.976960024766485 GO:0015385 sodium:proton antiporter activity 1/1250 16/18639 0.0625 0.93195 0.670821941805731 0.976960024766485 GO:0016722 oxidoreductase activity, acting on metal ions 1/1250 16/18639 0.0625 0.93195 0.670821941805731 0.976960024766485 GO:0019841 retinol binding 1/1250 16/18639 0.0625 0.93195 0.670821941805731 0.976960024766485 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/1250 16/18639 0.0625 0.93195 0.670821941805731 0.976960024766485 GO:0034450 ubiquitin-ubiquitin ligase activity 1/1250 16/18639 0.0625 0.93195 0.670821941805731 0.976960024766485 GO:0043023 ribosomal large subunit binding 1/1250 16/18639 0.0625 0.93195 0.670821941805731 0.976960024766485 GO:0097027 ubiquitin-protein transferase activator activity 1/1250 16/18639 0.0625 0.93195 0.670821941805731 0.976960024766485 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/1250 16/18639 0.0625 0.93195 0.670821941805731 0.976960024766485 GO:0140328 floppase activity 1/1250 16/18639 0.0625 0.93195 0.670821941805731 0.976960024766485 GO:0004527 exonuclease activity 5/1250 84/18639 0.0595238095238095 0.887571428571428 0.671953939843426 0.976960024766485 GO:0015020 glucuronosyltransferase activity 2/1250 34/18639 0.0588235294117647 0.877129411764706 0.675148246253411 0.976960024766485 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/1250 34/18639 0.0588235294117647 0.877129411764706 0.675148246253411 0.976960024766485 GO:0051427 hormone receptor binding 2/1250 34/18639 0.0588235294117647 0.877129411764706 0.675148246253411 0.976960024766485 GO:0052866 phosphatidylinositol phosphate phosphatase activity 2/1250 34/18639 0.0588235294117647 0.877129411764706 0.675148246253411 0.976960024766485 GO:0090482 vitamin transmembrane transporter activity 2/1250 34/18639 0.0588235294117647 0.877129411764706 0.675148246253411 0.976960024766485 GO:0015103 inorganic anion transmembrane transporter activity 10/1250 165/18639 0.0606060606060606 0.903709090909091 0.675261527475199 0.976960024766485 GO:0032934 sterol binding 4/1250 68/18639 0.0588235294117647 0.877129411764706 0.677207694845402 0.976960024766485 GO:0019842 vitamin binding 9/1250 150/18639 0.06 0.894672 0.682753515206658 0.976960024766485 GO:0017171 serine hydrolase activity 12/1250 198/18639 0.0606060606060606 0.903709090909091 0.683377579356385 0.976960024766485 GO:0051087 protein-folding chaperone binding 8/1250 134/18639 0.0597014925373134 0.890220895522388 0.683490186039741 0.976960024766485 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 3/1250 52/18639 0.0576923076923077 0.860261538461539 0.686772327393727 0.976960024766485 GO:0030159 signaling receptor complex adaptor activity 3/1250 52/18639 0.0576923076923077 0.860261538461539 0.686772327393727 0.976960024766485 GO:0005261 monoatomic cation channel activity 21/1250 341/18639 0.06158357771261 0.91828504398827 0.689653667204934 0.976960024766485 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 10/1250 167/18639 0.0598802395209581 0.89288622754491 0.689800257792109 0.976960024766485 GO:0005343 organic acid:sodium symporter activity 2/1250 35/18639 0.0571428571428571 0.852068571428571 0.690632818721425 0.976960024766485 GO:0016229 steroid dehydrogenase activity 2/1250 35/18639 0.0571428571428571 0.852068571428571 0.690632818721425 0.976960024766485 GO:0034061 DNA polymerase activity 2/1250 35/18639 0.0571428571428571 0.852068571428571 0.690632818721425 0.976960024766485 GO:0015297 antiporter activity 8/1250 135/18639 0.0592592592592593 0.883626666666667 0.691477787934433 0.976960024766485 GO:0050660 flavin adenine dinucleotide binding 5/1250 86/18639 0.0581395348837209 0.86693023255814 0.692057265295601 0.976960024766485 GO:0004550 nucleoside diphosphate kinase activity 1/1250 17/18639 0.0588235294117647 0.877129411764706 0.692916801535251 0.976960024766485 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/1250 17/18639 0.0588235294117647 0.877129411764706 0.692916801535251 0.976960024766485 GO:0008569 minus-end-directed microtubule motor activity 1/1250 17/18639 0.0588235294117647 0.877129411764706 0.692916801535251 0.976960024766485 GO:0016018 cyclosporin A binding 1/1250 17/18639 0.0588235294117647 0.877129411764706 0.692916801535251 0.976960024766485 GO:0017110 nucleoside diphosphate phosphatase activity 1/1250 17/18639 0.0588235294117647 0.877129411764706 0.692916801535251 0.976960024766485 GO:0030548 acetylcholine receptor regulator activity 1/1250 17/18639 0.0588235294117647 0.877129411764706 0.692916801535251 0.976960024766485 GO:0032183 SUMO binding 1/1250 17/18639 0.0588235294117647 0.877129411764706 0.692916801535251 0.976960024766485 GO:0032977 membrane insertase activity 1/1250 17/18639 0.0588235294117647 0.877129411764706 0.692916801535251 0.976960024766485 GO:0038191 neuropilin binding 1/1250 17/18639 0.0588235294117647 0.877129411764706 0.692916801535251 0.976960024766485 GO:0045125 bioactive lipid receptor activity 1/1250 17/18639 0.0588235294117647 0.877129411764706 0.692916801535251 0.976960024766485 GO:0046965 nuclear retinoid X receptor binding 1/1250 17/18639 0.0588235294117647 0.877129411764706 0.692916801535251 0.976960024766485 GO:0048038 quinone binding 1/1250 17/18639 0.0588235294117647 0.877129411764706 0.692916801535251 0.976960024766485 GO:0070402 NADPH binding 1/1250 17/18639 0.0588235294117647 0.877129411764706 0.692916801535251 0.976960024766485 GO:0070403 NAD+ binding 1/1250 17/18639 0.0588235294117647 0.877129411764706 0.692916801535251 0.976960024766485 GO:1990226 histone methyltransferase binding 1/1250 17/18639 0.0588235294117647 0.877129411764706 0.692916801535251 0.976960024766485 GO:0016782 transferase activity, transferring sulphur-containing groups 4/1250 70/18639 0.0571428571428571 0.852068571428571 0.699215199817657 0.976960024766485 GO:0008146 sulfotransferase activity 3/1250 53/18639 0.0566037735849057 0.844030188679245 0.699219679232825 0.976960024766485 GO:0016251 RNA polymerase II general transcription initiation factor activity 3/1250 53/18639 0.0566037735849057 0.844030188679245 0.699219679232825 0.976960024766485 GO:0140296 general transcription initiation factor binding 3/1250 53/18639 0.0566037735849057 0.844030188679245 0.699219679232825 0.976960024766485 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 3/1250 53/18639 0.0566037735849057 0.844030188679245 0.699219679232825 0.976960024766485 GO:0032182 ubiquitin-like protein binding 7/1250 120/18639 0.0583333333333333 0.86982 0.701800349208693 0.976960024766485 GO:0000993 RNA polymerase II complex binding 2/1250 36/18639 0.0555555555555556 0.8284 0.705503527094418 0.976960024766485 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/1250 36/18639 0.0555555555555556 0.8284 0.705503527094418 0.976960024766485 GO:0044390 ubiquitin-like protein conjugating enzyme binding 2/1250 36/18639 0.0555555555555556 0.8284 0.705503527094418 0.976960024766485 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 2/1250 36/18639 0.0555555555555556 0.8284 0.705503527094418 0.976960024766485 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 2/1250 36/18639 0.0555555555555556 0.8284 0.705503527094418 0.976960024766485 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 2/1250 36/18639 0.0555555555555556 0.8284 0.705503527094418 0.976960024766485 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3/1250 54/18639 0.0555555555555556 0.8284 0.711287275523434 0.976960024766485 GO:0140463 chromatin-protein adaptor activity 3/1250 54/18639 0.0555555555555556 0.8284 0.711287275523434 0.976960024766485 GO:0000900 mRNA regulatory element binding translation repressor activity 1/1250 18/18639 0.0555555555555556 0.8284 0.713529732374094 0.976960024766485 GO:0003746 translation elongation factor activity 1/1250 18/18639 0.0555555555555556 0.8284 0.713529732374094 0.976960024766485 GO:0008308 voltage-gated monoatomic anion channel activity 1/1250 18/18639 0.0555555555555556 0.8284 0.713529732374094 0.976960024766485 GO:0008409 5'-3' exonuclease activity 1/1250 18/18639 0.0555555555555556 0.8284 0.713529732374094 0.976960024766485 GO:0015172 acidic amino acid transmembrane transporter activity 1/1250 18/18639 0.0555555555555556 0.8284 0.713529732374094 0.976960024766485 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/1250 18/18639 0.0555555555555556 0.8284 0.713529732374094 0.976960024766485 GO:0022851 GABA-gated chloride ion channel activity 1/1250 18/18639 0.0555555555555556 0.8284 0.713529732374094 0.976960024766485 GO:0031690 adrenergic receptor binding 1/1250 18/18639 0.0555555555555556 0.8284 0.713529732374094 0.976960024766485 GO:0032393 MHC class I receptor activity 1/1250 18/18639 0.0555555555555556 0.8284 0.713529732374094 0.976960024766485 GO:0050811 GABA receptor binding 1/1250 18/18639 0.0555555555555556 0.8284 0.713529732374094 0.976960024766485 GO:0099602 neurotransmitter receptor regulator activity 1/1250 18/18639 0.0555555555555556 0.8284 0.713529732374094 0.976960024766485 GO:1901611 phosphatidylglycerol binding 1/1250 18/18639 0.0555555555555556 0.8284 0.713529732374094 0.976960024766485 GO:1990381 ubiquitin-specific protease binding 1/1250 18/18639 0.0555555555555556 0.8284 0.713529732374094 0.976960024766485 GO:0022829 wide pore channel activity 2/1250 37/18639 0.0540540540540541 0.806010810810811 0.719772993888989 0.979061538550822 GO:0023023 MHC protein complex binding 2/1250 37/18639 0.0540540540540541 0.806010810810811 0.719772993888989 0.979061538550822 GO:0030280 structural constituent of skin epidermis 2/1250 37/18639 0.0540540540540541 0.806010810810811 0.719772993888989 0.979061538550822 GO:0030551 cyclic nucleotide binding 2/1250 37/18639 0.0540540540540541 0.806010810810811 0.719772993888989 0.979061538550822 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 4/1250 73/18639 0.0547945205479452 0.81705205479452 0.73016459609599 0.979061538550822 GO:0003756 protein disulfide isomerase activity 1/1250 19/18639 0.0526315789473684 0.7848 0.732760054834347 0.979061538550822 GO:0004890 GABA-A receptor activity 1/1250 19/18639 0.0526315789473684 0.7848 0.732760054834347 0.979061538550822 GO:0008301 DNA binding, bending 1/1250 19/18639 0.0526315789473684 0.7848 0.732760054834347 0.979061538550822 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/1250 19/18639 0.0526315789473684 0.7848 0.732760054834347 0.979061538550822 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/1250 19/18639 0.0526315789473684 0.7848 0.732760054834347 0.979061538550822 GO:0016918 retinal binding 1/1250 19/18639 0.0526315789473684 0.7848 0.732760054834347 0.979061538550822 GO:0022840 leak channel activity 1/1250 19/18639 0.0526315789473684 0.7848 0.732760054834347 0.979061538550822 GO:0022842 narrow pore channel activity 1/1250 19/18639 0.0526315789473684 0.7848 0.732760054834347 0.979061538550822 GO:0031420 alkali metal ion binding 1/1250 19/18639 0.0526315789473684 0.7848 0.732760054834347 0.979061538550822 GO:0042577 lipid phosphatase activity 1/1250 19/18639 0.0526315789473684 0.7848 0.732760054834347 0.979061538550822 GO:0042800 histone H3K4 methyltransferase activity 1/1250 19/18639 0.0526315789473684 0.7848 0.732760054834347 0.979061538550822 GO:0070003 threonine-type peptidase activity 1/1250 19/18639 0.0526315789473684 0.7848 0.732760054834347 0.979061538550822 GO:0097001 ceramide binding 1/1250 19/18639 0.0526315789473684 0.7848 0.732760054834347 0.979061538550822 GO:0099589 serotonin receptor activity 1/1250 19/18639 0.0526315789473684 0.7848 0.732760054834347 0.979061538550822 GO:1990380 K48-linked deubiquitinase activity 1/1250 19/18639 0.0526315789473684 0.7848 0.732760054834347 0.979061538550822 GO:0042162 telomeric DNA binding 2/1250 38/18639 0.0526315789473684 0.7848 0.733454909946193 0.979061538550822 GO:0030170 pyridoxal phosphate binding 3/1250 56/18639 0.0535714285714286 0.798814285714286 0.734296153913117 0.979061538550822 GO:0031491 nucleosome binding 4/1250 74/18639 0.0540540540540541 0.806010810810811 0.739934420346294 0.985406124599107 GO:0070279 vitamin B6 binding 3/1250 57/18639 0.0526315789473684 0.7848 0.745245710519378 0.99032331021707 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 2/1250 39/18639 0.0512820512820513 0.764676923076923 0.746563834626129 0.99032331021707 GO:0004620 phospholipase activity 6/1250 109/18639 0.055045871559633 0.8208 0.747216331483973 0.99032331021707 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/1250 20/18639 0.05 0.74556 0.75070043783419 0.99032331021707 GO:0015095 magnesium ion transmembrane transporter activity 1/1250 20/18639 0.05 0.74556 0.75070043783419 0.99032331021707 GO:0015464 acetylcholine receptor activity 1/1250 20/18639 0.05 0.74556 0.75070043783419 0.99032331021707 GO:0016408 C-acyltransferase activity 1/1250 20/18639 0.05 0.74556 0.75070043783419 0.99032331021707 GO:0031418 L-ascorbic acid binding 1/1250 20/18639 0.05 0.74556 0.75070043783419 0.99032331021707 GO:0008408 3'-5' exonuclease activity 3/1250 58/18639 0.0517241379310345 0.771268965517241 0.75583191039498 0.993574465801258 GO:0004177 aminopeptidase activity 2/1250 40/18639 0.05 0.74556 0.759115017960599 0.993574465801258 GO:0015036 disulfide oxidoreductase activity 2/1250 40/18639 0.05 0.74556 0.759115017960599 0.993574465801258 GO:0030331 nuclear estrogen receptor binding 2/1250 40/18639 0.05 0.74556 0.759115017960599 0.993574465801258 GO:0071949 FAD binding 2/1250 40/18639 0.05 0.74556 0.759115017960599 0.993574465801258 GO:0015459 potassium channel regulator activity 3/1250 59/18639 0.0508474576271186 0.758196610169492 0.766060358945856 0.993574465801258 GO:0036002 pre-mRNA binding 3/1250 59/18639 0.0508474576271186 0.758196610169492 0.766060358945856 0.993574465801258 GO:0070063 RNA polymerase binding 3/1250 59/18639 0.0508474576271186 0.758196610169492 0.766060358945856 0.993574465801258 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/1250 21/18639 0.0476190476190476 0.710057142857143 0.767437343828457 0.993574465801258 GO:0009975 cyclase activity 1/1250 21/18639 0.0476190476190476 0.710057142857143 0.767437343828457 0.993574465801258 GO:0010314 phosphatidylinositol-5-phosphate binding 1/1250 21/18639 0.0476190476190476 0.710057142857143 0.767437343828457 0.993574465801258 GO:0015174 basic amino acid transmembrane transporter activity 1/1250 21/18639 0.0476190476190476 0.710057142857143 0.767437343828457 0.993574465801258 GO:0051010 microtubule plus-end binding 1/1250 21/18639 0.0476190476190476 0.710057142857143 0.767437343828457 0.993574465801258 GO:0051428 peptide hormone receptor binding 1/1250 21/18639 0.0476190476190476 0.710057142857143 0.767437343828457 0.993574465801258 GO:0061891 calcium ion sensor activity 1/1250 21/18639 0.0476190476190476 0.710057142857143 0.767437343828457 0.993574465801258 GO:0070182 DNA polymerase binding 1/1250 21/18639 0.0476190476190476 0.710057142857143 0.767437343828457 0.993574465801258 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/1250 41/18639 0.0487804878048781 0.727375609756098 0.771124242721037 0.993574465801258 GO:0042287 MHC protein binding 2/1250 41/18639 0.0487804878048781 0.727375609756098 0.771124242721037 0.993574465801258 GO:0008276 protein methyltransferase activity 5/1250 95/18639 0.0526315789473684 0.7848 0.771881701268995 0.993574465801258 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3/1250 60/18639 0.05 0.74556 0.775937129124323 0.993574465801258 GO:0015081 sodium ion transmembrane transporter activity 9/1250 164/18639 0.0548780487804878 0.81829756097561 0.778276440131305 0.993574465801258 GO:0140713 histone chaperone activity 9/1250 164/18639 0.0548780487804878 0.81829756097561 0.778276440131305 0.993574465801258 GO:0031492 nucleosomal DNA binding 2/1250 42/18639 0.0476190476190476 0.710057142857143 0.782607684533783 0.993574465801258 GO:0035198 miRNA binding 2/1250 42/18639 0.0476190476190476 0.710057142857143 0.782607684533783 0.993574465801258 GO:0043175 RNA polymerase core enzyme binding 2/1250 42/18639 0.0476190476190476 0.710057142857143 0.782607684533783 0.993574465801258 GO:0005243 gap junction channel activity 1/1250 22/18639 0.0454545454545455 0.677781818181818 0.783051444172985 0.993574465801258 GO:0015377 chloride:monoatomic cation symporter activity 1/1250 22/18639 0.0454545454545455 0.677781818181818 0.783051444172985 0.993574465801258 GO:0016881 acid-amino acid ligase activity 1/1250 22/18639 0.0454545454545455 0.677781818181818 0.783051444172985 0.993574465801258 GO:0034062 5'-3' RNA polymerase activity 1/1250 22/18639 0.0454545454545455 0.677781818181818 0.783051444172985 0.993574465801258 GO:0050321 tau-protein kinase activity 1/1250 22/18639 0.0454545454545455 0.677781818181818 0.783051444172985 0.993574465801258 GO:0097747 RNA polymerase activity 1/1250 22/18639 0.0454545454545455 0.677781818181818 0.783051444172985 0.993574465801258 GO:0140035 ubiquitin-like protein reader activity 1/1250 22/18639 0.0454545454545455 0.677781818181818 0.783051444172985 0.993574465801258 GO:0140784 metal ion sensor activity 1/1250 22/18639 0.0454545454545455 0.677781818181818 0.783051444172985 0.993574465801258 GO:0005262 calcium channel activity 7/1250 131/18639 0.0534351145038168 0.796781679389313 0.783327011877242 0.993574465801258 GO:0016741 transferase activity, transferring one-carbon groups 12/1250 215/18639 0.0558139534883721 0.832253023255814 0.784301046098426 0.993684583292123 GO:0016836 hydro-lyase activity 3/1250 61/18639 0.0491803278688525 0.733337704918033 0.785468701518806 0.994039486667867 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/1250 43/18639 0.0465116279069767 0.693544186046512 0.79358178833546 0.994801968281888 GO:0003887 DNA-directed DNA polymerase activity 1/1250 23/18639 0.0434782608695652 0.648313043478261 0.797618006711728 0.994801968281888 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/1250 23/18639 0.0434782608695652 0.648313043478261 0.797618006711728 0.994801968281888 GO:0005212 structural constituent of eye lens 1/1250 23/18639 0.0434782608695652 0.648313043478261 0.797618006711728 0.994801968281888 GO:0005283 amino acid:sodium symporter activity 1/1250 23/18639 0.0434782608695652 0.648313043478261 0.797618006711728 0.994801968281888 GO:0008171 O-methyltransferase activity 1/1250 23/18639 0.0434782608695652 0.648313043478261 0.797618006711728 0.994801968281888 GO:0016917 GABA receptor activity 1/1250 23/18639 0.0434782608695652 0.648313043478261 0.797618006711728 0.994801968281888 GO:0042171 lysophosphatidic acid acyltransferase activity 1/1250 23/18639 0.0434782608695652 0.648313043478261 0.797618006711728 0.994801968281888 GO:0070577 lysine-acetylated histone binding 1/1250 23/18639 0.0434782608695652 0.648313043478261 0.797618006711728 0.994801968281888 GO:0071617 lysophospholipid acyltransferase activity 1/1250 23/18639 0.0434782608695652 0.648313043478261 0.797618006711728 0.994801968281888 GO:0099186 structural constituent of postsynapse 1/1250 23/18639 0.0434782608695652 0.648313043478261 0.797618006711728 0.994801968281888 GO:0140103 catalytic activity, acting on a glycoprotein 1/1250 23/18639 0.0434782608695652 0.648313043478261 0.797618006711728 0.994801968281888 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/1250 23/18639 0.0434782608695652 0.648313043478261 0.797618006711728 0.994801968281888 GO:0015101 organic cation transmembrane transporter activity 4/1250 81/18639 0.0493827160493827 0.736355555555555 0.800897053958961 0.995764219247312 GO:0005507 copper ion binding 3/1250 63/18639 0.0476190476190476 0.710057142857143 0.803523882229723 0.995764219247312 GO:0019205 nucleobase-containing compound kinase activity 2/1250 44/18639 0.0454545454545455 0.677781818181818 0.804063159608742 0.995764219247312 GO:0005315 phosphate transmembrane transporter activity 1/1250 24/18639 0.0416666666666667 0.6213 0.811207257442838 0.995764219247312 GO:0015149 hexose transmembrane transporter activity 1/1250 24/18639 0.0416666666666667 0.6213 0.811207257442838 0.995764219247312 GO:0015295 solute:proton symporter activity 1/1250 24/18639 0.0416666666666667 0.6213 0.811207257442838 0.995764219247312 GO:0030552 cAMP binding 1/1250 24/18639 0.0416666666666667 0.6213 0.811207257442838 0.995764219247312 GO:0050431 transforming growth factor beta binding 1/1250 24/18639 0.0416666666666667 0.6213 0.811207257442838 0.995764219247312 GO:0055056 D-glucose transmembrane transporter activity 1/1250 24/18639 0.0416666666666667 0.6213 0.811207257442838 0.995764219247312 GO:0070300 phosphatidic acid binding 1/1250 24/18639 0.0416666666666667 0.6213 0.811207257442838 0.995764219247312 GO:0140033 acetylation-dependent protein binding 1/1250 24/18639 0.0416666666666667 0.6213 0.811207257442838 0.995764219247312 GO:0140612 DNA damage sensor activity 1/1250 24/18639 0.0416666666666667 0.6213 0.811207257442838 0.995764219247312 GO:0015291 secondary active transmembrane transporter activity 16/1250 287/18639 0.0557491289198606 0.831286411149826 0.811956469879876 0.995764219247312 GO:0008234 cysteine-type peptidase activity 10/1250 187/18639 0.053475935828877 0.797390374331551 0.812273778828015 0.995764219247312 GO:0008168 methyltransferase activity 11/1250 204/18639 0.053921568627451 0.804035294117647 0.812867923182128 0.995764219247312 GO:0140303 intramembrane lipid transporter activity 2/1250 45/18639 0.0444444444444444 0.66272 0.814068468974245 0.995764219247312 GO:0016779 nucleotidyltransferase activity 7/1250 136/18639 0.0514705882352941 0.767488235294118 0.81439287931298 0.995764219247312 GO:0099094 ligand-gated monoatomic cation channel activity 7/1250 136/18639 0.0514705882352941 0.767488235294118 0.81439287931298 0.995764219247312 GO:0140597 protein carrier chaperone 10/1250 188/18639 0.0531914893617021 0.793148936170213 0.817296462556655 0.996415039664184 GO:0160215 deacylase activity 3/1250 65/18639 0.0461538461538462 0.688209230769231 0.820283872124812 0.996415039664184 GO:0015271 outward rectifier potassium channel activity 1/1250 25/18639 0.04 0.596448 0.823884717995964 0.996415039664184 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/1250 25/18639 0.04 0.596448 0.823884717995964 0.996415039664184 GO:0015662 P-type ion transporter activity 1/1250 25/18639 0.04 0.596448 0.823884717995964 0.996415039664184 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/1250 25/18639 0.04 0.596448 0.823884717995964 0.996415039664184 GO:0017025 TBP-class protein binding 1/1250 25/18639 0.04 0.596448 0.823884717995964 0.996415039664184 GO:0042974 nuclear retinoic acid receptor binding 1/1250 25/18639 0.04 0.596448 0.823884717995964 0.996415039664184 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/1250 25/18639 0.04 0.596448 0.823884717995964 0.996415039664184 GO:0140358 P-type transmembrane transporter activity 1/1250 25/18639 0.04 0.596448 0.823884717995964 0.996415039664184 GO:0004175 endopeptidase activity 23/1250 405/18639 0.0567901234567901 0.846808888888889 0.824711376579195 0.996415039664184 GO:0004529 DNA exonuclease activity 1/1250 26/18639 0.0384615384615385 0.573507692307692 0.835711520537333 0.999999999999834 GO:0005227 calcium-activated cation channel activity 1/1250 26/18639 0.0384615384615385 0.573507692307692 0.835711520537333 0.999999999999834 GO:0008143 poly(A) binding 1/1250 26/18639 0.0384615384615385 0.573507692307692 0.835711520537333 0.999999999999834 GO:0015145 monosaccharide transmembrane transporter activity 1/1250 26/18639 0.0384615384615385 0.573507692307692 0.835711520537333 0.999999999999834 GO:0120014 phospholipid transfer activity 1/1250 26/18639 0.0384615384615385 0.573507692307692 0.835711520537333 0.999999999999834 GO:0008173 RNA methyltransferase activity 3/1250 67/18639 0.0447761194029851 0.667665671641791 0.835809981410828 0.999999999999834 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 3/1250 67/18639 0.0447761194029851 0.667665671641791 0.835809981410828 0.999999999999834 GO:0022832 voltage-gated channel activity 9/1250 175/18639 0.0514285714285714 0.766861714285714 0.837341347726788 0.999999999999834 GO:0008188 neuropeptide receptor activity 2/1250 48/18639 0.0416666666666667 0.6213 0.84139403352012 0.999999999999834 GO:0032266 phosphatidylinositol-3-phosphate binding 2/1250 48/18639 0.0416666666666667 0.6213 0.84139403352012 0.999999999999834 GO:0140693 molecular condensate scaffold activity 2/1250 48/18639 0.0416666666666667 0.6213 0.84139403352012 0.999999999999834 GO:0001217 DNA-binding transcription repressor activity 15/1250 278/18639 0.0539568345323741 0.804561151079137 0.842031387803917 0.999999999999834 GO:0140223 general transcription initiation factor activity 3/1250 68/18639 0.0441176470588235 0.657847058823529 0.843130086944617 0.999999999999834 GO:1990841 promoter-specific chromatin binding 3/1250 68/18639 0.0441176470588235 0.657847058823529 0.843130086944617 0.999999999999834 GO:0005385 zinc ion transmembrane transporter activity 1/1250 27/18639 0.037037037037037 0.552266666666667 0.846744701611224 0.999999999999834 GO:0008266 poly(U) RNA binding 1/1250 27/18639 0.037037037037037 0.552266666666667 0.846744701611224 0.999999999999834 GO:0008320 protein transmembrane transporter activity 1/1250 27/18639 0.037037037037037 0.552266666666667 0.846744701611224 0.999999999999834 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/1250 27/18639 0.037037037037037 0.552266666666667 0.846744701611224 0.999999999999834 GO:0015079 potassium ion transmembrane transporter activity 8/1250 160/18639 0.05 0.74556 0.848752349357205 0.999999999999834 GO:0002039 p53 binding 3/1250 69/18639 0.0434782608695652 0.648313043478261 0.850165590786695 0.999999999999834 GO:0003924 GTPase activity 18/1250 331/18639 0.054380664652568 0.810880966767372 0.852231929441984 0.999999999999834 GO:0003727 single-stranded RNA binding 4/1250 89/18639 0.0449438202247191 0.670166292134831 0.855821598272496 0.999999999999834 GO:0005242 inward rectifier potassium channel activity 1/1250 28/18639 0.0357142857142857 0.532542857142857 0.857037476325708 0.999999999999834 GO:0046875 ephrin receptor binding 1/1250 28/18639 0.0357142857142857 0.532542857142857 0.857037476325708 0.999999999999834 GO:0050698 proteoglycan sulfotransferase activity 1/1250 28/18639 0.0357142857142857 0.532542857142857 0.857037476325708 0.999999999999834 GO:0051119 sugar transmembrane transporter activity 1/1250 28/18639 0.0357142857142857 0.532542857142857 0.857037476325708 0.999999999999834 GO:0141052 histone H3 demethylase activity 1/1250 28/18639 0.0357142857142857 0.532542857142857 0.857037476325708 0.999999999999834 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 9/1250 181/18639 0.0497237569060773 0.741440883977901 0.863958090081967 0.999999999999834 GO:0016597 amino acid binding 2/1250 51/18639 0.0392156862745098 0.584752941176471 0.865025939814607 0.999999999999834 GO:0030544 Hsp70 protein binding 2/1250 51/18639 0.0392156862745098 0.584752941176471 0.865025939814607 0.999999999999834 GO:0005416 amino acid:monoatomic cation symporter activity 1/1250 29/18639 0.0344827586206897 0.514179310344828 0.866639494196476 0.999999999999834 GO:0106222 lncRNA binding 1/1250 29/18639 0.0344827586206897 0.514179310344828 0.866639494196476 0.999999999999834 GO:0015085 calcium ion transmembrane transporter activity 7/1250 147/18639 0.0476190476190476 0.710057142857143 0.870478562768323 0.999999999999834 GO:0001965 G-protein alpha-subunit binding 1/1250 30/18639 0.0333333333333333 0.49704 0.875597077874843 0.999999999999834 GO:0016769 transferase activity, transferring nitrogenous groups 1/1250 30/18639 0.0333333333333333 0.49704 0.875597077874843 0.999999999999834 GO:0022839 monoatomic ion-gated channel activity 1/1250 30/18639 0.0333333333333333 0.49704 0.875597077874843 0.999999999999834 GO:0032452 histone demethylase activity 1/1250 30/18639 0.0333333333333333 0.49704 0.875597077874843 0.999999999999834 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/1250 30/18639 0.0333333333333333 0.49704 0.875597077874843 0.999999999999834 GO:0016298 lipase activity 6/1250 130/18639 0.0461538461538462 0.688209230769231 0.875700005914922 0.999999999999834 GO:0004864 protein phosphatase inhibitor activity 2/1250 53/18639 0.0377358490566038 0.56268679245283 0.878937904118446 0.999999999999834 GO:0005544 calcium-dependent phospholipid binding 2/1250 53/18639 0.0377358490566038 0.56268679245283 0.878937904118446 0.999999999999834 GO:0031072 heat shock protein binding 6/1250 131/18639 0.0458015267175573 0.68295572519084 0.88013390962873 0.999999999999834 GO:0005452 solute:inorganic anion antiporter activity 1/1250 31/18639 0.032258064516129 0.481006451612903 0.8839534459041 0.999999999999834 GO:0072349 modified amino acid transmembrane transporter activity 1/1250 31/18639 0.032258064516129 0.481006451612903 0.8839534459041 0.999999999999834 GO:0140457 protein demethylase activity 1/1250 31/18639 0.032258064516129 0.481006451612903 0.8839534459041 0.999999999999834 GO:0003725 double-stranded RNA binding 3/1250 75/18639 0.04 0.596448 0.88685303532485 0.999999999999834 GO:0000510 H3-H4 histone complex chaperone activity 7/1250 151/18639 0.0463576158940397 0.691247682119205 0.887061850808148 0.999999999999834 GO:0140584 chromatin extrusion motor activity 7/1250 151/18639 0.0463576158940397 0.691247682119205 0.887061850808148 0.999999999999834 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 7/1250 151/18639 0.0463576158940397 0.691247682119205 0.887061850808148 0.999999999999834 GO:0140849 ATP-dependent H2AZ histone chaperone activity 7/1250 151/18639 0.0463576158940397 0.691247682119205 0.887061850808148 0.999999999999834 GO:0015616 DNA translocase activity 7/1250 152/18639 0.0460526315789474 0.6867 0.890917981755602 0.999999999999834 GO:0140674 ATP-dependent histone chaperone activity 7/1250 152/18639 0.0460526315789474 0.6867 0.890917981755602 0.999999999999834 GO:0008374 O-acyltransferase activity 2/1250 55/18639 0.0363636363636364 0.542225454545455 0.891514602893838 0.999999999999834 GO:0070717 poly-purine tract binding 1/1250 32/18639 0.03125 0.465975 0.891748920571978 0.999999999999834 GO:0061775 cohesin loader activity 7/1250 153/18639 0.0457516339869281 0.682211764705882 0.894662656300247 0.999999999999834 GO:0003724 RNA helicase activity 3/1250 77/18639 0.038961038961039 0.580955844155844 0.897168004341697 0.999999999999834 GO:0071889 14-3-3 protein binding 1/1250 33/18639 0.0303030303030303 0.451854545454546 0.899021121855636 0.999999999999834 GO:0005244 voltage-gated monoatomic ion channel activity 8/1250 173/18639 0.046242774566474 0.689535260115607 0.900729850208038 0.999999999999834 GO:0015932 nucleobase-containing compound transmembrane transporter activity 2/1250 57/18639 0.0350877192982456 0.5232 0.902868119244089 0.999999999999834 GO:0016887 ATP hydrolysis activity 22/1250 417/18639 0.052757793764988 0.786682014388489 0.903397288399515 0.999999999999834 GO:0008175 tRNA methyltransferase activity 1/1250 34/18639 0.0294117647058824 0.438564705882353 0.905805148389037 0.999999999999834 GO:0008376 acetylgalactosaminyltransferase activity 1/1250 34/18639 0.0294117647058824 0.438564705882353 0.905805148389037 0.999999999999834 GO:0015035 protein-disulfide reductase activity 1/1250 34/18639 0.0294117647058824 0.438564705882353 0.905805148389037 0.999999999999834 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/1250 34/18639 0.0294117647058824 0.438564705882353 0.905805148389037 0.999999999999834 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/1250 34/18639 0.0294117647058824 0.438564705882353 0.905805148389037 0.999999999999834 GO:0016831 carboxy-lyase activity 1/1250 34/18639 0.0294117647058824 0.438564705882353 0.905805148389037 0.999999999999834 GO:0008186 ATP-dependent activity, acting on RNA 3/1250 79/18639 0.0379746835443038 0.566248101265823 0.906628798051574 0.999999999999834 GO:0005085 guanyl-nucleotide exchange factor activity 11/1250 230/18639 0.0478260869565217 0.713144347826087 0.909882400600724 0.999999999999834 GO:0022836 gated channel activity 16/1250 318/18639 0.050314465408805 0.750249056603774 0.910847566072337 0.999999999999834 GO:0140658 ATP-dependent chromatin remodeler activity 7/1250 158/18639 0.0443037974683544 0.660622784810127 0.91179240802324 0.999999999999834 GO:0061631 ubiquitin conjugating enzyme activity 1/1250 35/18639 0.0285714285714286 0.426034285714286 0.912133746320437 0.999999999999834 GO:0140566 histone reader activity 1/1250 35/18639 0.0285714285714286 0.426034285714286 0.912133746320437 0.999999999999834 GO:0003697 single-stranded DNA binding 5/1250 121/18639 0.0413223140495868 0.616165289256198 0.914982090053711 0.999999999999834 GO:0003689 DNA clamp loader activity 7/1250 160/18639 0.04375 0.652365 0.917942356030483 0.999999999999834 GO:0004190 aspartic-type endopeptidase activity 1/1250 36/18639 0.0277777777777778 0.4142 0.918037466869752 0.999999999999834 GO:0016758 hexosyltransferase activity 9/1250 197/18639 0.0456852791878173 0.681222335025381 0.918097066879832 0.999999999999834 GO:0140996 histone H3 kinase activity 18/1250 357/18639 0.0504201680672269 0.751825210084034 0.920485159556682 0.999999999999834 GO:0070001 aspartic-type peptidase activity 1/1250 37/18639 0.027027027027027 0.403005405405405 0.92354481334144 0.999999999999834 GO:0003712 transcription coregulator activity 26/1250 495/18639 0.0525252525252525 0.783214545454545 0.923627653814417 0.999999999999834 GO:0019787 ubiquitin-like protein transferase activity 25/1250 479/18639 0.0521920668058455 0.778246346555324 0.925112349108628 0.999999999999834 GO:0016755 aminoacyltransferase activity 26/1250 496/18639 0.0524193548387097 0.781635483870968 0.925289218169879 0.999999999999834 GO:0035173 histone kinase activity 18/1250 360/18639 0.05 0.74556 0.926333919642318 0.999999999999834 GO:0042887 amide transmembrane transporter activity 1/1250 38/18639 0.0263157894736842 0.3924 0.928682378298068 0.999999999999834 GO:0003713 transcription coactivator activity 12/1250 256/18639 0.046875 0.6989625 0.9294899791994 0.999999999999834 GO:1901682 sulfur compound transmembrane transporter activity 2/1250 63/18639 0.0317460317460317 0.473371428571429 0.930610578336355 0.999999999999834 GO:0046873 metal ion transmembrane transporter activity 23/1250 450/18639 0.0511111111111111 0.762128 0.933249180037112 0.999999999999834 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/1250 39/18639 0.0256410256410256 0.382338461538462 0.933474971552593 0.999999999999834 GO:0004536 DNA nuclease activity 2/1250 64/18639 0.03125 0.465975 0.934434725814432 0.999999999999834 GO:0019001 guanyl nucleotide binding 20/1250 400/18639 0.05 0.74556 0.935751204155853 0.999999999999834 GO:0032561 guanyl ribonucleotide binding 20/1250 400/18639 0.05 0.74556 0.935751204155853 0.999999999999834 GO:0004843 cysteine-type deubiquitinase activity 4/1250 108/18639 0.037037037037037 0.552266666666667 0.937048154290216 0.999999999999834 GO:0015144 carbohydrate transmembrane transporter activity 1/1250 40/18639 0.025 0.37278 0.937945739593413 0.999999999999834 GO:0032451 demethylase activity 1/1250 40/18639 0.025 0.37278 0.937945739593413 0.999999999999834 GO:0061791 GTPase motor activity 1/1250 40/18639 0.025 0.37278 0.937945739593413 0.999999999999834 GO:1990606 membrane scission GTPase motor activity 1/1250 40/18639 0.025 0.37278 0.937945739593413 0.999999999999834 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 5/1250 130/18639 0.0384615384615385 0.573507692307692 0.94161737446021 0.999999999999834 GO:0001727 lipid kinase activity 1/1250 41/18639 0.024390243902439 0.363687804878049 0.942116277015223 0.999999999999834 GO:0016877 ligase activity, forming carbon-sulfur bonds 1/1250 41/18639 0.024390243902439 0.363687804878049 0.942116277015223 0.999999999999834 GO:0140318 protein transporter activity 1/1250 41/18639 0.024390243902439 0.363687804878049 0.942116277015223 0.999999999999834 GO:0004222 metalloendopeptidase activity 4/1250 110/18639 0.0363636363636364 0.542225454545455 0.942557854284953 0.999999999999834 GO:0001216 DNA-binding transcription activator activity 25/1250 491/18639 0.0509164969450102 0.759226069246436 0.943113173182084 0.999999999999834 GO:0141003 histone H2AX kinase activity 17/1250 354/18639 0.0480225988700565 0.716074576271186 0.945686534733649 0.999999999999834 GO:0004402 histone acetyltransferase activity 1/1250 42/18639 0.0238095238095238 0.355028571428571 0.94600673049038 0.999999999999834 GO:0004520 DNA endonuclease activity 1/1250 42/18639 0.0238095238095238 0.355028571428571 0.94600673049038 0.999999999999834 GO:0019894 kinesin binding 1/1250 42/18639 0.0238095238095238 0.355028571428571 0.94600673049038 0.999999999999834 GO:0061659 ubiquitin-like protein ligase activity 18/1250 372/18639 0.0483870967741935 0.721509677419355 0.946252418446742 0.999999999999834 GO:0003777 microtubule motor activity 2/1250 68/18639 0.0294117647058824 0.438564705882353 0.947822668556171 0.999999999999834 GO:0005548 phospholipid transporter activity 2/1250 68/18639 0.0294117647058824 0.438564705882353 0.947822668556171 0.999999999999834 GO:0003774 cytoskeletal motor activity 6/1250 153/18639 0.0392156862745098 0.584752941176471 0.948685895716197 0.999999999999834 GO:0005245 voltage-gated calcium channel activity 1/1250 43/18639 0.0232558139534884 0.346772093023256 0.949635895779783 0.999999999999834 GO:0008375 acetylglucosaminyltransferase activity 1/1250 43/18639 0.0232558139534884 0.346772093023256 0.949635895779783 0.999999999999834 GO:0052689 carboxylic ester hydrolase activity 3/1250 92/18639 0.0326086956521739 0.486234782608696 0.951134969800794 0.999999999999834 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 12/1250 268/18639 0.0447761194029851 0.667665671641791 0.951421018957439 0.999999999999834 GO:0043014 alpha-tubulin binding 1/1250 44/18639 0.0227272727272727 0.338890909090909 0.953021308248877 0.999999999999834 GO:0101005 deubiquitinase activity 4/1250 115/18639 0.0347826086956522 0.518650434782609 0.954459151171617 0.999999999999834 GO:0004842 ubiquitin-protein transferase activity 22/1250 449/18639 0.0489977728285078 0.730615590200445 0.955236168943666 0.999999999999834 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 24/1250 484/18639 0.0495867768595041 0.739398347107438 0.955508493718887 0.999999999999834 GO:0016410 N-acyltransferase activity 3/1250 94/18639 0.0319148936170213 0.475889361702128 0.955891661490516 0.999999999999834 GO:0042605 peptide antigen binding 1/1250 45/18639 0.0222222222222222 0.33136 0.9561793273233 0.999999999999834 GO:0015294 solute:monoatomic cation symporter activity 4/1250 116/18639 0.0344827586206897 0.514179310344828 0.956548317122332 0.999999999999834 GO:0140767 enzyme-substrate adaptor activity 5/1250 139/18639 0.0359712230215827 0.536374100719424 0.960487999604119 0.999999999999834 GO:0061733 protein-lysine-acetyltransferase activity 1/1250 47/18639 0.0212765957446809 0.317259574468085 0.961873210819556 0.999999999999834 GO:0061749 forked DNA-dependent helicase activity 1/1250 47/18639 0.0212765957446809 0.317259574468085 0.961873210819556 0.999999999999834 GO:0140359 ABC-type transporter activity 1/1250 47/18639 0.0212765957446809 0.317259574468085 0.961873210819556 0.999999999999834 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/1250 47/18639 0.0212765957446809 0.317259574468085 0.961873210819556 0.999999999999834 GO:0035064 methylated histone binding 2/1250 74/18639 0.027027027027027 0.403005405405405 0.963125203581357 0.999999999999834 GO:0005249 voltage-gated potassium channel activity 3/1250 98/18639 0.0306122448979592 0.456465306122449 0.964132649730975 0.999999999999834 GO:0009378 four-way junction helicase activity 1/1250 48/18639 0.0208333333333333 0.31065 0.964436597570607 0.999999999999834 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/1250 48/18639 0.0208333333333333 0.31065 0.964436597570607 0.999999999999834 GO:0036121 double-stranded DNA helicase activity 1/1250 48/18639 0.0208333333333333 0.31065 0.964436597570607 0.999999999999834 GO:0043138 3'-5' DNA helicase activity 1/1250 48/18639 0.0208333333333333 0.31065 0.964436597570607 0.999999999999834 GO:0061630 ubiquitin protein ligase activity 16/1250 353/18639 0.0453257790368272 0.675861756373938 0.966543440721041 0.999999999999834 GO:0017022 myosin binding 2/1250 76/18639 0.0263157894736842 0.3924 0.967190360010822 0.999999999999834 GO:0140034 methylation-dependent protein binding 2/1250 76/18639 0.0263157894736842 0.3924 0.967190360010822 0.999999999999834 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 4/1250 122/18639 0.0327868852459016 0.488891803278689 0.967331789006485 0.999999999999834 GO:0015605 organophosphate ester transmembrane transporter activity 1/1250 50/18639 0.02 0.298224 0.96905828404856 0.999999999999834 GO:0008194 UDP-glycosyltransferase activity 5/1250 145/18639 0.0344827586206897 0.514179310344828 0.969766063178695 0.999999999999834 GO:0005267 potassium channel activity 4/1250 124/18639 0.032258064516129 0.481006451612903 0.970332720444111 0.999999999999834 GO:0015293 symporter activity 5/1250 146/18639 0.0342465753424658 0.510657534246575 0.971100628463241 0.999999999999834 GO:0016874 ligase activity 6/1250 167/18639 0.0359281437125748 0.535731736526946 0.971358487721024 0.999999999999834 GO:0015370 solute:sodium symporter activity 2/1250 79/18639 0.0253164556962025 0.377498734177215 0.97248962183035 0.999999999999834 GO:0005525 GTP binding 17/1250 378/18639 0.044973544973545 0.670609523809524 0.972731742084563 0.999999999999834 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 9/1250 229/18639 0.0393013100436681 0.586029694323144 0.973630421089763 0.999999999999834 GO:0019783 ubiquitin-like protein peptidase activity 4/1250 127/18639 0.031496062992126 0.469644094488189 0.974354463887789 0.999999999999834 GO:0034212 protein N-acetyltransferase activity 1/1250 53/18639 0.0188679245283019 0.281343396226415 0.974890191581245 0.999999999999834 GO:1901505 carbohydrate derivative transmembrane transporter activity 1/1250 53/18639 0.0188679245283019 0.281343396226415 0.974890191581245 0.999999999999834 GO:0031490 chromatin DNA binding 4/1250 128/18639 0.03125 0.465975 0.975577244411592 0.999999999999834 GO:0004497 monooxygenase activity 3/1250 106/18639 0.0283018867924528 0.422015094339623 0.976457715242176 0.999999999999834 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 1/1250 54/18639 0.0185185185185185 0.276133333333333 0.976578949814509 0.999999999999834 GO:0140098 catalytic activity, acting on RNA 17/1250 387/18639 0.0439276485788114 0.655013953488372 0.979249765044828 0.999999999999834 GO:0004386 helicase activity 5/1250 155/18639 0.032258064516129 0.481006451612903 0.980875237719275 0.999999999999834 GO:0017116 single-stranded DNA helicase activity 1/1250 58/18639 0.0172413793103448 0.257089655172414 0.982272749755278 0.999999999999834 GO:0003730 mRNA 3'-UTR binding 10/1250 262/18639 0.0381679389312977 0.569129770992366 0.98407649375981 0.999999999999834 GO:0022843 voltage-gated monoatomic cation channel activity 4/1250 143/18639 0.027972027972028 0.417096503496503 0.988454459142223 0.999999999999834 GO:0008094 ATP-dependent activity, acting on DNA 7/1250 210/18639 0.0333333333333333 0.49704 0.988987780563591 0.999999999999834 GO:0016407 acetyltransferase activity 2/1250 96/18639 0.0208333333333333 0.31065 0.990048622563641 0.999999999999834 GO:0042626 ATPase-coupled transmembrane transporter activity 2/1250 98/18639 0.0204081632653061 0.304310204081633 0.991186606117937 0.999999999999834 GO:0008080 N-acetyltransferase activity 1/1250 69/18639 0.0144927536231884 0.216104347826087 0.991761492347986 0.999999999999834 GO:0003823 antigen binding 5/1250 174/18639 0.028735632183908 0.42848275862069 0.992274340368142 0.999999999999834 GO:0003678 DNA helicase activity 1/1250 74/18639 0.0135135135135135 0.201502702702703 0.994185510537761 0.999999999999834 GO:0140097 catalytic activity, acting on DNA 12/1250 336/18639 0.0357142857142857 0.532542857142857 0.99569305624008 0.999999999999834 GO:0000049 tRNA binding 1/1250 80/18639 0.0125 0.18639 0.996173061310002 0.999999999999834 GO:0035403 histone H3T6 kinase activity 7/1250 247/18639 0.0283400809716599 0.422584615384615 0.997952278039784 0.999999999999834 GO:0042393 histone binding 7/1250 247/18639 0.0283400809716599 0.422584615384615 0.997952278039784 0.999999999999834 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 6/1250 243/18639 0.0246913580246914 0.368177777777778 0.999204331479084 0.999999999999834 GO:0004676 3-phosphoinositide-dependent protein kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:0004711 ribosomal protein S6 kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:0035175 histone H3S10 kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:0035979 histone H2AXS139 kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:0044022 histone H3S28 kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:0044023 histone H4S1 kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:0044024 histone H2AS1 kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:0044025 histone H2BS14 kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:0072354 histone H3T3 kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:0072371 histone H2AS121 kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:0072518 Rho-dependent protein serine/threonine kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:0140823 histone H2BS36 kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:0140855 histone H3S57 kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:0140995 histone H2A kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:0140997 histone H4 kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:0140998 histone H2B kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:1990244 histone H2AT120 kinase activity 6/1250 245/18639 0.0244897959183673 0.365172244897959 0.999281241622388 0.999999999999834 GO:0140101 catalytic activity, acting on a tRNA 2/1250 139/18639 0.0143884892086331 0.21454964028777 0.99931213682657 0.999999999999834 GO:0004677 DNA-dependent protein kinase activity 6/1250 246/18639 0.024390243902439 0.363687804878049 0.999316940550374 0.999999999999834 GO:0140857 histone H3T45 kinase activity 6/1250 246/18639 0.024390243902439 0.363687804878049 0.999316940550374 0.999999999999834 GO:0035402 histone H3T11 kinase activity 6/1250 247/18639 0.0242914979757085 0.362215384615385 0.999350915550638 0.999999999999834 GO:0004679 AMP-activated protein kinase activity 6/1250 248/18639 0.0241935483870968 0.360754838709677 0.999383247029699 0.999999999999834 GO:0005549 odorant binding 1/1250 111/18639 0.00900900900900901 0.134335135135135 0.999560150212325 0.999999999999834 GO:0106310 protein serine kinase activity 9/1250 361/18639 0.0249307479224377 0.371747368421053 0.999921739645346 0.999999999999834 GO:0045182 translation regulator activity 8/1250 356/18639 0.0224719101123595 0.335083146067416 0.999970180509431 0.999999999999834 GO:0004674 protein serine/threonine kinase activity 11/1250 433/18639 0.0254041570438799 0.378806466512702 0.999976807293739 0.999999999999834 GO:0030371 translation repressor activity 2/1250 329/18639 0.0060790273556231 0.0906455927051672 0.999999997547695 0.999999999999834 GO:0004984 olfactory receptor activity 1/1250 419/18639 0.00238663484486874 0.0355875894988067 0.999999999999834 0.999999999999834