category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	110/1706	268/9376	2.2557785515564	UCHL1/MT-CO2/MT-CO1/TXN/NDUFA13/COX4I1/TUBA4A/PSMA7/COX5B/PSMD2/UQCRH/COX7A2/NDUFA4/COX6A1/NDUFS5/GNAS/PSMB5/NDUFA11/SLC25A6/SLC39A8/NDUFC2/NDUFS8/RPS27A/UBB/ATP5F1D/ATP5F1B/UQCRQ/PSMB1/ADRM1/COX6B1/COX8A/SLC25A5/PARK7/TUBB/HSPA5/ATP5MC3/NDUFB9/UQCR10/PSMD8/TUBB3/NDUFS6/PSMB3/DDIT3/NDUFB10/PSMA6/ATP5MC2/NDUFB2/COX5A/ATP5PF/UQCR11/PRKACA/PSMB6/NDUFA5/NDUFV3/VDAC3/TP53/CALM2/NDUFV2/UQCRC1/CALM3/TUBA1B/ITPR3/UQCRC2/CASP3/HTRA2/EIF2S1/UBA1/GNAI2/ATP5F1A/SOD1/NDUFB7/NDUFS1/MFN2/SLC39A4/SDHA/MT-CO3/SLC39A1/SLC39A9/UBA52/BAX/UBE2L6/MAPK9/NDUFB11/VDAC2/TUBA1C/PSMC5/CYCS/KLC2/PSMA2/UBE2J1/NDUFC1/CYC1/PRKACB/UQCRFS1/PLCG1/TUBB6/COX7B/SDHB/ATP5MC1/VDAC1/PSMB2/NDUFA2/TXN2/PSMA4/PINK1/NDUFAB1/ATP5PO/NDUFA12/PSMD12/PSMB7	9.83663183201662
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	118/1706	308/9376	2.10557086524261	PLCB1/MT-CO2/MT-CO1/AP2S1/AP2M1/NDUFA13/COX4I1/TUBA4A/PSMA7/COX5B/PSMD2/CLTA/UQCRH/COX7A2/NDUFA4/COX6A1/NDUFS5/PSMB5/NDUFA11/SLC25A6/NDUFC2/GRIA4/NDUFS8/ATP5F1D/ATP5F1B/UQCRQ/PSMB1/ADRM1/COX6B1/COX8A/SLC25A5/TUBB/ATP5MC3/NDUFB9/UQCR10/PSMD8/TUBB3/NDUFS6/GRIA3/PSMB3/NDUFB10/PSMA6/DNAH14/ATP5MC2/CREB1/NDUFB2/IFT57/NRBF2/COX5A/ATP5PF/UQCR11/POLR2C/PSMB6/NDUFA5/POLR2L/NDUFV3/VDAC3/TP53/ATG13/NDUFV2/UQCRC1/TUBA1B/CLTC/UQCRC2/CASP3/ATP5F1A/ATG14/ACTR1A/SOD1/NDUFB7/NDUFS1/BECN1/DCTN2/SDHA/MT-CO3/CREB3L1/BAX/MAPK9/NDUFB11/REST/MAP3K10/VDAC2/TUBA1C/NRF1/PSMC5/CYCS/ATG101/DNAL4/DCTN4/KLC2/PSMA2/TFAM/NDUFC1/CYC1/UQCRFS1/TUBB6/COX7B/SDHB/MAP2K7/ATP5MC1/VDAC1/PSMB2/TBPL1/PIK3C3/NDUFA2/PSMA4/DLG4/NDUFAB1/ATP5PO/WIPI1/NDUFA12/POLR2D/PSMD12/DCTN5/PSMB7/AP2A1/POLR2J/ACTR10	9.30429898342629
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	106/1706	275/9376	2.11841841628477	PRNP/MT-CO2/MT-CO1/CYBA/IL6/NDUFA13/COX4I1/TUBA4A/PSMA7/COX5B/PSMD2/UQCRH/COX7A2/RAC2/NDUFA4/COX6A1/NDUFS5/PSMB5/NDUFA11/SLC25A6/NDUFC2/IL1A/NDUFS8/ATP5F1D/ATP5F1B/UQCRQ/PSMB1/ADRM1/COX6B1/STIP1/COX8A/RAC1/SLC25A5/TUBB/HSPA5/ATP5MC3/NDUFB9/UQCR10/PSMD8/TUBB3/NDUFS6/PSMB3/IL1B/DDIT3/NDUFB10/PSMA6/HSPA8/ATP5MC2/CREB1/NDUFB2/CSNK2A2/COX5A/ATP5PF/MAPK3/UQCR11/PRKACA/PSMB6/NDUFA5/NDUFV3/VDAC3/NDUFV2/UQCRC1/TUBA1B/ITPR3/UQCRC2/CASP3/CSNK2B/EIF2S1/PPP3R1/ATP5F1A/SOD1/NDUFB7/NDUFS1/SDHA/MT-CO3/CREB3L1/BAX/CSNK2A1/MAPK9/NDUFB11/VDAC2/TUBA1C/PSMC5/CYCS/KLC2/PSMA2/NDUFC1/CYC1/PRKACB/UQCRFS1/TUBB6/COX7B/ATF6B/SDHB/ATP5MC1/VDAC1/PPP3CC/CAV2/PSMB2/NDUFA2/PSMA4/NDUFAB1/ATP5PO/NDUFA12/PSMD12/PSMB7	8.87776345234137
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	66/1706	138/9376	2.62847239920485	MT-CO2/MT-CO1/ATP6V0E1/NDUFA13/COX4I1/ATP6V0B/COX5B/ATP6V1F/UQCRH/ATP6V1G1/COX7A2/NDUFA4/COX6A1/ATP6V0C/NDUFS5/NDUFA11/NDUFC2/NDUFS8/ATP5F1D/ATP5F1B/UQCRQ/COX6B1/COX8A/ATP5MC3/NDUFB9/UQCR10/NDUFS6/NDUFB10/ATP6V1A/ATP5MC2/NDUFB2/ATP6AP1/COX5A/ATP5PF/UQCR11/NDUFA5/NDUFV3/ATP5MG/NDUFV2/ATP5MF/UQCRC1/UQCRC2/ATP6V0A2/ATP5F1A/NDUFB7/NDUFS1/COX11/SDHA/MT-CO3/TCIRG1/NDUFB11/CYCS/NDUFC1/CYC1/UQCRFS1/PPA2/COX7B/ATP6V0D1/SDHB/ATP5MC1/ATP6V1C1/NDUFA2/NDUFAB1/ATP5PO/NDUFA12/ATP6V1E1	9.0888395369543
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	154/1706	480/9376	1.76326690113326	PLCB1/UCHL1/PRNP/SQSTM1/MT-CO2/MT-CO1/IL6/NDUFA13/COX4I1/TUBA4A/PSMA7/COX5B/PSMD2/UQCRH/COX7A2/NDUFA4/COX6A1/NDUFS5/PSMB5/NDUFA11/SLC25A6/NDUFC2/IL1A/GRIA4/NDUFS8/RPS27A/UBB/ATP5F1D/ATP5F1B/UQCRQ/PSMB1/ADRM1/COX6B1/COX8A/RAC1/SLC25A5/PARK7/TUBB/HSPA5/ATP5MC3/NDUFB9/UQCR10/PSMD8/TUBB3/NDUFS6/GRIA3/PSMB3/IL1B/DDIT3/NDUFB10/PSMA6/DNAH14/ATP5MC2/MAP2K2/NDUFB2/CAT/IFT57/SIGMAR1/CSNK2A2/BID/NRBF2/COX5A/ATP5PF/MAPK3/RAB8A/UQCR11/PSMB6/NDUFA5/CHMP2B/NDUFV3/VDAC3/CALM2/ATG13/NDUFV2/TBK1/UQCRC1/CCS/CALM3/TUBA1B/ITPR3/UQCRC2/CASP3/HTRA2/CSNK2B/EIF2S1/PPP3R1/PPID/UBA1/ATP5F1A/ATG14/ACTR1A/SOD1/NDUFB7/NDUFS1/BECN1/MFN2/VCP/DCTN2/SDHA/MT-CO3/ZFYVE1/KRAS/UBA52/BAX/CSNK2A1/DVL1/UBE2L6/MAPK9/NDUFB11/MAP3K10/DERL1/APP/VDAC2/TUBA1C/ALS2/PSMC5/CYCS/ATG101/DNAL4/VAPB/DCTN4/KLC2/PSMA2/UBE2J1/NDUFC1/CYC1/UQCRFS1/PLCG1/TUBB6/COX7B/SDHB/MAP2K7/ATP5MC1/VDAC1/PPP3CC/PSMB2/DVL3/OPTN/PIK3C3/NDUFA2/PSMA4/DLG4/TNFRSF1A/PINK1/NDUFAB1/ATP5PO/WIPI1/ATP2A2/NDUFA12/PSMD12/DCTN5/PSMB7/ARAF/ACTR10	8.09612362243418
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	125/1706	368/9376	1.86681278352617	SQSTM1/PFN1/MT-CO2/MT-CO1/NDUFA13/COX4I1/TUBA4A/PSMA7/COX5B/PSMD2/UQCRH/COX7A2/NDUFA4/COX6A1/NDUFS5/PSMB5/NDUFA11/NDUFC2/ACTG1/NDUFS8/ATP5F1D/ATP5F1B/UQCRQ/PSMB1/ADRM1/COX6B1/COX8A/RAC1/TUBB/HSPA5/ATP5MC3/NDUFB9/UQCR10/PSMD8/TUBB3/NDUFS6/PSMB3/DDIT3/NDUFB10/TPR/PSMA6/DNAH14/PFN2/ATP5MC2/NDUFB2/CAT/SIGMAR1/BID/NRBF2/COX5A/ATP5PF/RAB8A/UQCR11/PSMB6/NDUFA5/CHMP2B/NDUFV3/TP53/ATG13/NDUFV2/TBK1/UQCRC1/NUP188/CCS/TUBA1B/ITPR3/UQCRC2/CASP3/EIF2S1/PPP3R1/ATP5F1A/ATG14/ACTR1A/SOD1/NDUFB7/NDUFS1/BECN1/NUP37/VCP/DCTN2/SDHA/MT-CO3/UBQLN4/BAX/ACTB/NDUFB11/POM121C/NUP133/DERL1/TUBA1C/ALS2/PSMC5/CYCS/ATG101/DNAL4/VAPB/DCTN4/KLC2/PSMA2/NDUFC1/CYC1/UQCRFS1/TUBB6/COX7B/UBQLN2/SDHB/ATP5MC1/VDAC1/PPP3CC/NUP62/PSMB2/OPTN/PIK3C3/NDUFA2/PSMA4/TNFRSF1A/PINK1/NDUFAB1/ATP5PO/WIPI1/NDUFA12/PSMD12/DCTN5/PSMB7/ACTR10	8.00041467478098
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	89/1706	235/9376	2.08142475867402	MT-CO2/MT-CO1/NDUFA13/COX4I1/COX5B/UQCRH/COX7A2/NDUFA4/COX6A1/NDUFS5/GNAS/NDUFA11/NDUFC2/ACTG1/NDUFS8/ATP5F1D/ATP5F1B/UQCRQ/COX6B1/COX8A/ATP5MC3/NDUFB9/UQCR10/NDUFS6/SMARCC2/NDUFB10/SMARCE1/ATP5MC2/CREB1/NDUFB2/COX5A/ATP5PF/UQCR11/PRKACA/COA5/NDUFA5/NDUFV3/ATP5MG/RPS6/NDUFV2/ATP5MF/UQCRC1/UQCRC2/SMARCD1/ATP5F1A/ADCY8/NDUFB7/COX20/NDUFS1/COX11/SDHA/MT-CO3/CREB3L1/TSC1/SMARCD2/KRAS/ACTB/NDUFB11/SMARCB1/COA6/NDUFAF5/GRB2/NDUFAF8/PRKAG1/NDUFC1/CYC1/PRKACB/UQCRFS1/COX14/COX7B/ADCY6/SDHB/CPT1C/ACSL5/ATP5MC1/AKT1S1/PRKAB1/NDUFAF6/NDUFA2/COX19/TSC2/SLC25A29/PNPLA2/NDUFAB1/ATP5PO/NDUFA12/ADCY10/NDUFAF3/ACTL6A	7.91791535345996
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	85/1706	227/9376	2.05793493810392	NQO1/CYP1B1/HIF1A/MT-CO2/MT-CO1/CYBA/GSTO1/MGST1/NDUFA13/COX4I1/GSTM3/COX5B/UQCRH/COX7A2/CBR1/HMOX1/NDUFA4/COX6A1/NDUFS5/AKR1C1/NDUFA11/SLC25A6/NDUFC2/NDUFS8/VEGFA/ATP5F1D/ATP5F1B/UQCRQ/COX6B1/COX8A/RAC1/SLC25A5/ATP5MC3/NDUFB9/UQCR10/NDUFS6/NDUFB10/EPHX1/ATP5MC2/MAP2K2/NDUFB2/CAT/COX5A/ATP5PF/MAPK3/UQCR11/NDUFA5/NDUFV3/VDAC3/NDUFV2/MGST3/UQCRC1/UQCRC2/ATP5F1A/SOD1/NDUFB7/NDUFS1/SDHA/MT-CO3/KRAS/AHR/MAPK9/NDUFB11/VDAC2/GRB2/AKR1C3/NDUFC1/CYC1/UQCRFS1/AKR1A1/PRKD2/PDPK1/COX7B/MGST2/SDHB/MAP2K7/ATP5MC1/VDAC1/CHUK/NDUFA2/AKR1C2/NDUFAB1/ATP5PO/NDUFA12/ARAF	7.60961254033019
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	78/1706	205/9376	2.09112172247162	PLCB1/GAPDH/COL1A1/CTSD/COL3A1/MT-CO2/MT-CO1/COL1A2/CYBA/G6PD/MPC2/NDUFA13/COX4I1/MMP2/COX5B/UQCRH/COX7A2/RAC2/NDUFA4/COX6A1/NDUFS5/NDUFA11/SLC25A6/NDUFC2/NDUFS8/ATP5F1D/ATP5F1B/UQCRQ/COX6B1/COX8A/RAC1/SLC25A5/ATP5MC3/NDUFB9/UQCR10/NDUFS6/MPC1/NDUFB10/ATP5MC2/NDUFB2/PDHA1/COX5A/ATP5PF/UQCR11/NDUFA5/GYS1/NDUFV3/VDAC3/NDUFV2/PARP1/GFPT1/UQCRC1/UQCRC2/PPP1CC/PPP1CA/TGFB1/ATP5F1A/NDUFB7/NDUFS1/SDHA/MT-CO3/MAPK9/NDUFB11/VDAC2/NDUFC1/GSR/CYC1/UQCRFS1/COX7B/SDHB/ATP5MC1/VDAC1/PDK2/NDUFA2/NDUFAB1/ATP5PO/ATP2A2/NDUFA12	7.44936502202863
Genetic Information Processing	Translation	hsa03010	Ribosome	82/1706	222/9376	2.03001594795264	RPS19/RPS14/RPL19/RPS27L/RPL28/RPL15/RPS10/RPS5/RPS2/RPS26/RACK1/RPLP0/RPLP1/RPS12/RPS4X/RPS27A/RPS7/RPS15/RPL29/RPL18/MRPL14/MRPL11/MRPL41/RPL7A/RPL7/MRPS14/RPL36AL/MRPS10/RPL10A/MRPL18/RPS3/RPL11/RPSA/RPL6/MRPL48/MRPL42/RPL17/MRPL16/RPL4/MRPS34/MRPL10/RPL5/RPS6/RPL13A/MRPS12/MRPL45/MRPS17/MRPL32/MRPL3/MRPL19/RPLP2/MRPL9/MRPL51/MRPS6/UBA52/RPL23A/MRPL54/MRPL40/FAU/MRPS25/MRPS30/MRPL17/MRPS9/MRPL12/MRPL2/MRPS22/MRPL34/MRPL47/MRPL44/RPL27/MRPS18A/MRPL46/MRPL23/MRPL28/RPS10-NUDT3/RPL22/MRPL35/MRPL20/MRPL38/MRPS33/MRPS35/MRPL49	7.32474401961354
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	121/1706	388/9376	1.71392659020316	PLCB1/GAPDH/MT-CO2/MT-CO1/IL6/NDUFA13/COX4I1/TUBA4A/PSMA7/COX5B/PSMD2/UQCRH/COX7A2/NDUFA4/COX6A1/NDUFS5/PSMB5/NDUFA11/SLC25A6/SLC39A8/NDUFC2/IL1A/NDUFS8/ATP5F1D/ATP5F1B/UQCRQ/PSMB1/ADRM1/COX6B1/COX8A/SLC25A5/TUBB/ATP5MC3/NDUFB9/UQCR10/PSMD8/TUBB3/NDUFS6/PSMB3/IL1B/DDIT3/NDUFB10/PSMA6/ATP5MC2/MAP2K2/NDUFB2/CSNK2A2/BID/NRBF2/PSENEN/COX5A/ATP5PF/MAPK3/UQCR11/PSMB6/NDUFA5/APBB1/NDUFV3/VDAC3/CALM2/ATG13/NDUFV2/UQCRC1/CALM3/TUBA1B/ITPR3/UQCRC2/CASP3/CSNK2B/EIF2S1/BACE1/PPP3R1/PPID/ATP5F1A/ATG14/NDUFB7/NDUFS1/BECN1/SLC39A4/SDHA/MT-CO3/SLC39A1/SLC39A9/KRAS/CSNK2A1/DVL1/MAPK9/NDUFB11/APP/VDAC2/TUBA1C/PSMC5/CYCS/ATG101/KLC2/PSMA2/NDUFC1/CYC1/UQCRFS1/TUBB6/COX7B/SDHB/MAP2K7/ATP5MC1/VDAC1/PPP3CC/CHUK/PSMB2/DVL3/PIK3C3/NDUFA2/PSMA4/TNFRSF1A/NDUFAB1/ATP5PO/WIPI1/ATP2A2/NDUFA12/PSMD12/PSMB7/ARAF	6.77353467102725
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	85/1706	250/9376	1.86860492379836	CTSD/AP2S1/PSAP/ATP6V0E1/AP2M1/ATP6V0B/ATP6V1F/CTSL/CLTA/ATP6V1G1/CD63/NPC2/CTSB/ATP6V0C/AP1S1/SLC2A6/LAMTOR1/VAMP8/CTSA/BORCS7/ASAH1/LAMP1/VPS16/ATP6V1A/HEXA/GAA/CLN8/ATP6AP1/LAMTOR5/AGA/PPT1/BLOC1S6/PLEKHM1/TMEM175/NAGA/AP5Z1/RRAGB/VPS26B/CLTC/ATP6V0A2/SLC15A3/VPS35/CLN5/LAMP2/AP3D1/LAMTOR4/AP4M1/GNPTG/AP3B1/TCIRG1/SNAP29/GGA1/TPP1/RRAGC/AP3M1/CTSZ/CTBS/ARSA/GALNS/AP3S1/SCARB2/TFEB/ARSB/LGMN/DMXL2/VPS29/SGSH/VAMP7/ATP6V0D1/SMPD1/AKT1S1/FUCA1/ATP6V1C1/LAMTOR3/AP5B1/VPS11/HEXB/SNAPIN/AP4E1/OSTM1/AP2A1/BORCS6/CD68/ACP2/ATP6V1E1	6.56492136792081
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	60/1706	157/9376	2.1003427393762	MT-CO2/MT-CO1/IL6/NDUFA13/COX4I1/COX5B/UQCRH/COX7A2/NDUFA4/COX6A1/NDUFS5/CXCL8/NDUFA11/NDUFC2/IL1A/NDUFS8/UQCRQ/COX6B1/COX8A/RAC1/NDUFB9/UQCR10/NDUFS6/IL1B/DDIT3/NDUFB10/SREBF1/NDUFB2/BID/COX5A/UQCR11/NDUFA5/NDUFV3/NDUFV2/UQCRC1/UQCRC2/CASP3/EIF2S1/TGFB1/NDUFB7/NDUFS1/SDHA/MT-CO3/BAX/MAPK9/NDUFB11/CYCS/PRKAG1/ADIPOR2/NDUFC1/CYC1/UQCRFS1/COX7B/SDHB/PRKAB1/NDUFA2/TNFRSF1A/NDUFAB1/NDUFA12/MLXIP	6.55712360574194
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	46/1706	116/9376	2.1794073654849	PKM/GAPDH/ME1/TPI1/G6PD/TKT/GPI/PGAM1/ENO1/PFKP/PGD/ACAT2/TALDO1/SUCLG1/HK2/H6PD/CAT/PGK1/IDH3A/ACAT1/RPIA/PDHA1/IDH1/FH/PGP/RPE/MMUT/ACSS2/SDHA/PFKL/HK1/GPT2/ME2/ACADS/ACOX3/PCCB/OGDH/IDH3G/IDH3B/SDHB/SUCLA2/MDH2/PRPS1/PGLS/GOT1/ESD	6.02788289463834
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	61/1706	174/9376	1.92672245354462	P4HB/CALR/SEC61G/PDIA3/CKAP4/OSTC/SEC61B/SSR4/RPN2/HSPA5/SSR2/TUSC3/STUB1/DNAJB12/DDIT3/FBXO2/HSPA8/DAD1/SKP1/DNAJB2/HSP90B1/BCAP31/MAN1A2/MAGT1/SEL1L/UGGT1/SEC63/EIF2S1/SEC24C/NPLOC4/SYVN1/CUL1/MBTPS1/SAR1B/VCP/UBQLN4/UBE2D4/BAX/MAPK9/DERL1/HYOU1/CANX/ERO1A/EDEM3/DNAJA2/UBE2J1/EDEM1/UBE4B/UBE2D2/UBQLN2/PLAA/MBTPS2/ATF6B/STT3A/MAP2K7/UGGT2/HERPUD1/SEC61A1/UBXN1/BAG1/UFD1	5.81916491121829
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	79/1706	250/9376	1.73670339976553	HLA-C/AP2S1/HLA-A/ARPC1B/HLA-B/AP2M1/SH3KBP1/CLTA/ARPC2/CHMP4A/ACTR3C/ARPC3/CAPZB/NEDD4L/HSPA8/CHMP1A/SNX5/EPS15L1/SH3GLB1/SH3GLB2/ARFGAP2/DAB2/RAB8A/PRKCI/ARPC1A/ARPC4/CHMP2B/RAB35/RBSN/TSG101/RAB11B/STAMBP/HLA-F/VPS4A/VPS26B/WIPF2/RAB4A/CLTC/RNF41/VPS35/PSD3/GIT2/BIN1/ARFGAP1/SH3GL1/ZFYVE9/SNX3/AGAP1/ARAP1/ARFGEF2/SNX2/PSD4/PML/VTA1/ARF6/RUFY1/WWP1/CAPZA1/VPS28/GIT1/VPS29/CAPZA2/EHD2/SNX12/ZFYVE27/DNAJC6/RAB5B/RAB31/CAV2/ACTR3/DNM1/CHMP3/CHMP7/AGAP4/HGS/SNF8/AP2A1/CYTH2/EPN1	5.56800883627433
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	25/1706	51/9376	2.69406707583385	ATP6V0E1/SEC61G/ATP6V0B/ATP6V1F/ATP6V1G1/ATP6V0C/GNAS/SEC61B/ACTG1/ATP6V1A/ATP6AP1/PRKACA/KDELR1/ATP6V0A2/SLC12A2/TCIRG1/ACTB/ERO1A/PRKACB/PLCG1/ATP6V0D1/ATP6V1C1/SEC61A1/KDELR2/ATP6V1E1	5.72095773715001
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	18/1706	31/9376	3.19116590401997	SEC61G/SRP14/SEC61B/SEC11A/SPCS1/HSPA5/TMEM208/SRP68/SGTA/SEC63/SRP19/SRPRB/SRP72/SRP54/SRPRA/SPCS2/SEC61A1/OXA1L	5.76293770541263
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	15/1706	23/9376	3.58428054437025	FDPS/ACAT2/IDI1/FNTA/PMVK/HMGCS1/ACAT1/ICMT/PCYOX1/MVK/GGPS1/MVD/HMGCR/FNTB/DHDDS	5.85201699238168
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	76/1706	248/9376	1.68422644934387	GAPDH/PFN1/ARPC1B/TXN/IL6/TUBA4A/BRK1/ARPC2/CXCL8/MYL12A/ACTG1/DYNLL1/DYNLT1/RAC1/TUBB/ACTR3C/ARPC3/TUBB3/IL1B/CD14/VPS16/PFN2/MYL5/SKP1/MAP2K2/RPS3/PLEKHM1/MAPK3/RHOG/HSP90B1/TRADD/ARPC1A/ARPC4/PYCARD/TUBA1B/CASP3/GSDMD/RALA/ACTR1A/DYNLT3/DCTN2/MYD88/BAX/ACTB/MAPK9/ACBD3/TUBA1C/CYCS/ARF6/DCTN4/KLC2/IRAK1/EXOC7/TUBB6/STX10/ELMO2/RAB5B/FHOD1/CASP4/MYL12B/MAP2K7/BIRC3/CHUK/ACTR3/PKN1/DYNC1H1/PIK3C3/TXN2/VPS11/TNFRSF1A/DCTN5/KPNA3/CYTH2/MLKL/TAB2/ACTR10	5.15009633187048
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	75/1706	253/9376	1.62921842925921	PLCB1/SQSTM1/PFN1/ITGB1/ARPC1B/ARPC2/CXCL8/MYL12A/ACTG1/RPS27A/UBB/RAC1/ACTR3C/ARPC3/HK2/IL1B/CD14/PFN2/MYL5/SKP1/BCL10/MAPK3/TNIP1/TRADD/ARPC1A/ARPC4/ILK/TP53/PYCARD/RRAGB/TBK1/ITPR3/IRF3/PPID/ATG14/CUL1/BECN1/ATG12/ARHGEF2/RBCK1/MYD88/UBA52/UBE2D4/BAX/ACTB/MAPK9/RRAGC/HK1/CYCS/ARF6/CRK/PXN/PLCG1/ELMO2/UBE2D2/SEPTIN9/SHARPIN/CASP4/MYL12B/C3/VDAC1/AKT1S1/CRKL/CHUK/ACTR3/GLMN/SEPTIN2/PLCD4/PIK3C3/TNFRSF1A/WIPI1/TIFA/CYTH2/TAB2/UBE2V1	4.78487202836791
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	54/1706	169/9376	1.75608537913525	CTSD/SQSTM1/HIF1A/GABARAP/DDIT4/CTSL/CTSB/RPS27A/UBB/VAMP8/WDR45B/LAMP1/VPS16/MAP2K2/NRBF2/SH3GLB1/PLEKHM1/MAPK3/RAB8A/IGBP1/PRKACA/RRAGB/ATG13/TBK1/EIF2S1/GABARAPL2/ATG14/BECN1/ATG12/LAMP2/SUPT20H/TSC1/ZFYVE1/KRAS/UBA52/MAPK9/SNAP29/WDR45/GORASP2/RRAGC/ATG16L2/ATG101/NBR1/PRKACB/ATG4B/PDPK1/AKT1S1/OPTN/PIK3C3/MTMR4/TSC2/VPS11/MTMR14/WIPI1	4.67770242366361
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	32/1706	83/9376	2.11889998446306	PRDX1/PRDX5/PMVK/PHYH/GSTK1/CAT/IDH1/CRAT/ECI2/GNPAT/SCP2/PEX3/ABCD4/SOD1/HSD17B4/HMGCL/PEX16/PXMP2/MVK/ACOX3/MLYCD/PEX26/ACSL5/PEX6/ACOX2/HACL1/PEX13/DECR2/PEX2/PEX14/NUDT13/ABCD1	4.82869545151947
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	46/1706	142/9376	1.78036094645245	RPS27A/UBE2M/UBB/RNF7/CDC26/ELOB/STUB1/NEDD4L/FBXO2/SKP1/ANAPC11/UBE4A/UBE2S/TRIM32/CDC16/UBA1/SYVN1/FZR1/CUL1/ELOC/UBE2Q1/UBE2F/XIAP/UBA52/UBE2D4/UBE2L6/CUL4A/UBOX5/CUL5/PML/HUWE1/UBE2J1/WWP1/CUL4B/UBE4B/ANAPC13/ANAPC5/UBE3B/UBE2D2/VHL/BIRC3/PIAS4/CUL7/PRPF19/PIAS3/ANAPC15	4.41898200989002
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	20/1706	46/9376	2.3895203629135	POMP/PSMA7/PSMD2/PSMB5/PSMB1/ADRM1/PSMD8/PSMB3/PSMA6/PSMF1/PSMB6/PSMC5/PSMB10/PSMA2/PSMB9/PSME3/PSMB2/PSMA4/PSMD12/PSMB7	4.45533617632779
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	20/1706	48/9376	2.28995701445877	ACAT2/BCAT1/HMGCS1/ACAT1/ALDH2/ACADM/MMUT/ALDH9A1/HMGCL/MCCC1/ACSF3/IVD/ACADS/ACAD8/IL4I1/BCAT2/PCCB/AACS/DBT/ALDH3A2	4.22550926278904
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	38/1706	117/9376	1.78499213434735	CDK2AP1/ACTG1/ZNHIT1/TFPT/SMARCC2/SMARCE1/RBBP4/MBD3/BRD7/BAZ1B/MBD2/ARID2/SMARCA5/RUVBL1/BCL7B/MEAF6/SMARCD1/EPC1/ACTR6/SMARCD2/ACTB/SMARCB1/KAT5/NFRKB/INO80E/DMAP1/SRCAP/RUVBL2/CHD4/DPF2/BCL7C/INO80B/INO80C/MTA2/MRGBP/SS18L1/ACTL6A/MORF4L1	4.02952322798787
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	28/1706	78/9376	1.97288604322602	ENO1/PFKP/TENT4A/LSM6/PATL1/XRN2/PNPT1/C1D/EXOSC7/EXOSC9/CNOT8/EXOSC6/CNOT10/EDC3/LSM8/PFKL/EXOSC3/LSM2/CNOT9/EXOSC8/LSM3/NUDT16/CNOT3/DCPS/LSM5/TOB1/DIS3/EXOSC1	4.0690401320236
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	66/1706	238/9376	1.52407223147172	IL6/RPS19/RPS14/RPL19/RPS27L/CFB/RPL28/RPL15/RPS10/RPS5/MMP1/RPS2/RPS26/CXCL8/RPLP0/RPLP1/RPS12/RPS4X/RPS27A/RPS7/RPS15/NRP1/RPL29/RPL18/IKBKE/RPL7A/IL1B/RPL7/STAT2/RPL36AL/RPL10A/RPS3/RPL11/RPSA/RPL6/MAPK3/RPL17/RPL4/RPL5/RPS6/RPL13A/TBK1/IRF3/RPLP2/MYD88/UBA52/MAPK9/RPL23A/CCL2/FAU/IRF9/IRAK1/MX1/PLCG1/RPL27/IFNAR2/C3/CHUK/RPS10-NUDT3/RPL22/TNFRSF1A/TYK2/MMP3/IFIH1/TAB2/ADAR	3.86217119154501
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	29/1706	83/9376	1.92025311091965	PHF1/TEX10/SCML1/SKP1/USP16/SUZ12/RBBP4/E2F6/JARID2/CSNK2B/RING1/MBD6/PCGF3/KDM2B/UBE2D4/HCFC1/PHF19/WDR5/PCGF2/PCGF6/UBE2D2/L3MBTL3/PHC2/MTF2/TFDP1/FBRS/PCGF1/ASXL2/BAP1	3.97142020971317
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	30/1706	87/9376	1.89513683955209	MT-CO2/MT-CO1/ATP1B1/COX4I1/COX5B/ASPH/UQCRH/COX7A2/COX6A1/TPM2/UQCRQ/CACNG8/ATP1B3/COX6B1/COX8A/UQCR10/COX5A/UQCR11/UQCRC1/TPM4/UQCRC2/MT-CO3/ATP1A1/CYC1/UQCRFS1/COX7B/SLC9A1/CACNB3/ATP2A2/CACNA2D1	3.95587031296365
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	60/1706	214/9376	1.54090565458908	HLA-C/B2M/HLA-A/HLA-B/CALR/CFL1/PDIA3/RAC2/GNG11/AP1S1/RNF7/RAC1/ELOB/SKP1/MAP2K2/BID/TAPBPL/MAPK3/GNG5/TRADD/CALM2/HLA-F/TBK1/CALM3/TAPBP/ITPR3/CASP3/IRF3/PPP3R1/GNAI2/CUL1/ELOC/MYD88/KRAS/BAX/MAPK9/CUL4A/CUL5/TRIM5/CYCS/TAP1/GNG12/GNG10/CUL4B/IRAK1/CRK/PXN/CHEK1/PLCG1/MAP2K7/CRKL/PPP3CC/LIMK2/CHUK/LIMK1/GNB2/GNG2/TNFRSF1A/APOBEC3C/TAB2	3.77494591871636
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	11/1706	20/9376	3.02274325908558	MSMO1/SQLE/DHCR24/DHCR7/EBP/FDFT1/LBR/HSD17B7/CYP51A1/LSS/NSDHL	4.27059240580611
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	21/1706	54/9376	2.13729321349485	GCLM/LDHB/LACC1/BCAT1/LDHA/MAT2A/AHCYL1/SRM/MTAP/IL4I1/BCAT2/MPST/APIP/TST/MDH2/ADI1/CISD1/GOT1/MRI1/DNMT3A/KYAT3	3.95268538435095
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	42/1706	138/9376	1.67266425403945	FN1/ITGB1/ARPC1B/IL6/RAC2/ARPC2/CXCL8/ACTG1/RAC1/ACTR3C/ARPC3/IL1B/SKAP2/MAP2K2/MAPK3/RHOG/ARPC1A/ARPC4/PYCARD/TBK1/WIPF2/IRF3/GIT2/BAIAP2/MYD88/ACTB/MAPK9/CCL2/ARF6/ARHGEF1/IRAK1/CRK/PXN/PLCG1/ELMO2/MAP2K7/CRKL/CHUK/ACTR3/LIMK1/PKN1/TAB2	3.75427761022836
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	46/1706	155/9376	1.63104035094354	ITGA2/HLA-C/CYBA/ITGB1/HLA-A/HLA-B/CALR/ATP6V0E1/SEC61G/TUBA4A/ATP6V0B/ATP6V1F/CTSL/ATP6V1G1/ATP6V0C/SEC61B/ACTG1/RAC1/TUBB/TUBB3/CD14/LAMP1/ATP6V1A/ATP6AP1/HLA-F/MRC2/VAMP3/TUBA1B/ATP6V0A2/LAMP2/TCIRG1/ACTB/TUBA1C/CANX/TAP1/TUBB6/RAB5B/THBS2/ATP6V0D1/C3/ATP6V1C1/SEC61A1/DYNC1H1/PIK3C3/HGS/ATP6V1E1	3.73603931867421
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	27/1706	78/9376	1.90242582739652	FN1/ITGB1/ARPC1B/CLTA/ARPC2/SHC3/ACTG1/RAC1/ACTR3C/ARPC3/SHC1/RHOG/ARPC1A/ARPC4/ILK/CLTC/ACTB/CRK/PXN/ELMO2/SEPTIN9/CRKL/CAV2/ACTR3/DNM1/SEPTIN2/MAD2L2	3.7743443164987
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	62/1706	227/9376	1.50108195485227	PLCB1/HLA-C/B2M/HLA-A/HLA-B/CALR/IL6/PDIA3/RAC2/GNG11/CXCL8/GNAS/VEGFA/RAC1/CDKN2A/IL1B/CREB1/MAP2K2/BID/TAPBPL/MAPK3/CCND1/GNG5/PRKACA/TRADD/TP53/CALM2/HLA-F/TBK1/CALM3/TAPBP/ITPR3/CASP3/IRF3/PPP3R1/GNAI2/ADCY8/CREB3L1/TSC1/KRAS/BAX/GRB2/CCL2/CYCS/TAP1/GNG12/GNG10/PRKACB/ARHGEF1/CRK/PXN/ADCY6/IL10RB/ATF6B/CRKL/PPP3CC/CHUK/E2F1/GNB2/GNG2/TSC2/TNFRSF1A	3.60422875740441
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	55/1706	196/9376	1.54221594851305	HLA-C/HIF1A/HLA-A/HLA-B/IL6/GNG11/CXCL8/CXCL1/RPS27A/VEGFA/UBB/RAC1/IKBKE/STAT2/CREB1/MAP2K2/ICAM1/BID/MAPK3/CCND1/GNG5/TRADD/TP53/CALM2/HLA-F/TBK1/CALM3/ITPR3/CASP3/IRF3/PPP3R1/ATG14/BECN1/KRAS/UBA52/BAX/MAPK9/CYCS/IRF9/GNG12/GNG10/PLCG1/CXCL3/MAP2K7/IFNAR2/C3/PPP3CC/CHUK/E2F1/GNB2/PIK3C3/IRF7/GNG2/TNFRSF1A/TYK2	3.61789911418565
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	26/1706	75/9376	1.9052442360297	PKM/GAPDH/TPI1/TKT/PGAM1/ENO1/PFKP/TALDO1/BCAT1/PGK1/IDH3A/RPIA/IDH1/ALDH18A1/RPE/MAT2A/PYCR2/PFKL/GPT2/BCAT2/IDH3G/IDH3B/PYCR1/NAGS/PRPS1/GOT1	3.71200922938623
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	14/1706	31/9376	2.48201792534886	G6PD/TKT/GPI/PFKP/PGD/TALDO1/H6PD/RPIA/RPE/PFKL/PGM2/PGM1/PRPS1/PGLS	3.89782305685811
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	16/1706	38/9376	2.31406182513729	GPI/HK2/HEXA/GFPT1/PGM3/GALT/PMM1/HK1/PGM2/UXS1/GALE/PGM1/MPI/UAP1L1/HEXB/FCSK	3.8278783895141
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	50/1706	180/9376	1.52663800963918	HLA-C/B2M/HLA-A/HLA-B/CALR/IL6/PDIA3/SRSF9/IKBKE/IL1B/STAT2/BID/TAPBPL/TRADD/POU2F2/TP53/HLA-F/TBK1/TAPBP/CASP3/IRF3/EIF2S1/PPP1CC/PPP1CA/EIF2B2/TSC1/MYD88/BAX/HCFC1/CCL2/EIF2B4/CYCS/PML/IRF9/TAP1/IRAK1/EIF2B5/IFNAR2/C3/BIRC3/SP100/CHUK/IRF7/SRSF8/TSC2/TNFRSF1A/TYK2/IFIH1/TAB2/NECTIN1	3.36454577747863
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	18/1706	47/9376	2.1048115537153	PKM/ME1/LDHB/ACAT2/ACAT1/LDHA/PDHA1/ALDH2/FH/ACSS2/ALDH9A1/GLO1/ME2/AKR1A1/ALDH3A2/HAGH/MDH2/GRHPR	3.58094012412056
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	14/1706	33/9376	2.33159259653984	VAMP8/USE1/VTI1B/VAMP2/VAMP5/STX4/VAMP3/SNAP29/GOSR2/VAMP4/BET1L/VAMP7/STX3/STX6	3.61378771377314
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	23/1706	67/9376	1.88665115221081	PKM/GAPDH/TPI1/GPI/LDHB/PGAM1/ENO1/PFKP/HK2/PGK1/LDHA/PDHA1/ALDH3B1/ALDH2/ACSS2/ALDH9A1/PFKL/HK1/PGM2/PGM1/AKR1A1/G6PC3/ALDH3A2	3.43491613959733
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	15/1706	37/9376	2.22806628433827	GPI/HK2/GFPT1/PGM3/GALT/PMM1/HK1/PGM2/UXS1/NANS/GALE/PGM1/MPI/UAP1L1/FCSK	3.52979880924959
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	13/1706	30/9376	2.38155529503712	SUCLG1/ACLY/IDH3A/PDHA1/IDH1/FH/SDHA/OGDH/IDH3G/IDH3B/SDHB/SUCLA2/MDH2	3.57432040441206
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	32/1706	105/9376	1.67493998771842	SQSTM1/HIF1A/GABARAP/FIS1/RPS27A/UBB/BNIP3L/CSNK2A2/TP53/MTX2/TBK1/CSNK2B/EIF2S1/GABARAPL2/BECN1/MFN2/VCP/CCZ1/KRAS/UBA52/CSNK2A1/MAPK9/NBR1/HUWE1/MUL1/TFEB/RAB5B/E2F1/RHOT2/OPTN/PINK1/MON1B	3.28000108895291
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	29/1706	95/9376	1.67769482322453	IL6/ATP6V0E1/ATP6V0B/ATP6V1F/CTSL/ATP6V1G1/MMP1/IL11/ATP6V0C/CXCL8/CXCL1/IL1A/VEGFA/CXCL6/IL1B/ATP6V1A/CXCL5/ICAM1/ATP6AP1/ATP6V0A2/TGFB1/TCIRG1/CCL2/CXCL3/ATP6V0D1/ATP6V1C1/MMP3/TNFSF13B/ATP6V1E1	3.1309494372991
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	13/1706	32/9376	2.2327080890973	AKR1B1/PFKP/HK2/GAA/AKR1B10/B4GALT2/GALT/PFKL/HK1/PGM2/GALE/PGM1/G6PC3	3.29417213914119
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	19/1706	56/9376	1.86467928320214	IL6/EEF1A1/CXCL8/CXCL1/IL1B/CD14/HSPA8/EEF1G/PYCARD/NFKB2/CASP3/SAR1B/VCP/HBS1L/MYD88/CYCS/CXCL3/EEF1A2/C3	3.06068461742512
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	19/1706	57/9376	1.83196561156702	SCD/FADS1/ACAT2/FADS2/ACAT1/PPT1/SCP2/MECR/ACADM/HSD17B4/HACD4/ACSF3/ACADS/ACOX3/CPT1C/ACSL5/ACADVL/TECR/MCAT	2.97122552392483
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	39/1706	144/9376	1.4884720593982	PLCB1/PSMA7/PSMD2/PSMB5/SLC25A6/PSMB1/ADRM1/SLC25A5/PSMD8/GRIA3/PSMB3/PSMA6/NRBF2/PSMB6/VDAC3/AFG3L2/ATG13/NFYA/ITPR3/ATG14/BECN1/NOP56/MAPK9/VDAC2/PSMC5/CYCS/ATG101/KAT5/PSMA2/VDAC1/PSMB2/TBPL1/ATXN10/PIK3C3/PSMA4/WIPI1/ATP2A2/PSMD12/PSMB7	2.78580391835106
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	40/1706	149/9376	1.47540854622847	PLCB1/NDUFA13/NDUFA4/NDUFS5/GNG11/NDUFA11/NDUFC2/GRIA4/NDUFS8/NDUFB9/NDUFS6/GRIA3/NDUFB10/NDUFB2/MAPK3/GNG5/PRKACA/NDUFA5/NDUFV3/NDUFV2/ITPR3/GNAI2/ADCY8/NDUFB7/NDUFS1/MAPK9/NDUFB11/GABRE/GNG12/GNG10/NDUFC1/PRKACB/ADCY6/KCNJ6/GNB2/GNG2/NDUFA2/NAPEPLD/NDUFAB1/NDUFA12	2.75871812438097
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	51/1706	200/9376	1.40145369284877	GAPDH/ITGB1/ARPC1B/IL6/TUBA4A/BRK1/ARPC2/CXCL8/ACTG1/RAC1/TUBB/ACTR3C/ARPC3/TUBB3/IL1B/MYO1C/MYO5B/RPS3/MAPK3/TRADD/ARPC1A/ARPC4/PYCARD/NCK1/WIPF2/TUBA1B/CASP3/SEC24C/TMBIM6/BAIAP2/ARHGEF2/CLDN11/MYD88/MYO1B/BAX/ACTB/MAPK9/TUBA1C/CYCS/ARF6/ARHGEF1/IRAK1/TUBB6/CASP4/CHUK/ACTR3/TNFRSF1A/ABCF2/CLDN14/CYTH2/TAB2	2.70645756582716
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	45/1706	173/9376	1.42956854081819	IL33/IL6/FDPS/CXCL8/SLC25A6/IL1A/ACTG1/SLC25A5/IKBKE/IL1B/PRSS3/STAT2/MAP2K2/ICAM1/BID/MAPK3/TRADD/RAB11B/PYCARD/TRIM25/TBK1/CASP3/IRF3/EIF2S1/PABPN1/MYD88/BAX/ACTB/HNRNPUL1/CCL2/CYCS/PML/IRF9/XPO1/CPSF4/MX1/IFNAR2/VDAC1/CHUK/IRF7/TNFRSF1A/TYK2/IFIH1/KPNA2/ADAR	2.68947975052408
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	25/1706	85/9376	1.61644024550031	NME2/AK1/GUK1/LACC1/AK4/APRT/GMPS/HPRT1/DCTD/NT5C3A/NME7/GMPR2/UCKL1/DUT/AK2/ITPA/NME1/UCK1/NUDT16/UPP1/DGUOK/DCTPP1/ADSL/ASMTL/TYMS	2.69244404957114
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	9/1706	21/9376	2.35538435772902	CSGALNACT1/CHPF2/CSGALNACT2/CHST12/DSE/CHST14/B3GAT3/CHST15/B3GALT6	2.93243024596618
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	18/1706	56/9376	1.76653826829677	MGAT4B/OSTC/RPN2/TUSC3/DAD1/SRD5A3/DPM1/MAN1A2/MAGT1/ALG5/B4GALT2/DPM2/ALG8/DPAGT1/STT3A/B4GALT3/ALG6/MGAT2	2.71329720975301
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	15/1706	44/9376	1.87360119364809	MPG/TDG/APTX/PARP1/NTHL1/NEIL2/POLD2/POLG/SMUG1/POLE4/POLL/TDP1/MUTYH/PARP2/PCNA	2.73923733021066
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	15/1706	44/9376	1.87360119364809	GNAS/DYNLL1/CREB1/VAMP2/PRKACA/RAB11B/STX4/DCTN2/CREB3L1/DCTN4/PRKACB/RAB5B/ADCY6/DYNC1H1/DCTN5	2.73923733021066
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	30/1706	108/9376	1.52663800963918	EEF1A1/SUMO2/PNN/RAN/TPR/RNPS1/THOC7/NUP188/AAAS/PHAX/NUP37/NCBP2/NUP42/UPF3A/POM121C/NUP133/XPO5/XPO1/SNUPN/THOC5/IPO9/XPO6/EEF1A2/MAGOHB/UPF3B/NUP62/KPNA3/SUMO1/XPOT/KPNA2	2.59602299812161
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	20/1706	65/9376	1.69104517990802	AKR1B1/DGKI/PLPP4/GPAM/PLPP2/PNPLA3/ALDH2/ABHD16A/AKR1B10/ALDH9A1/DGAT2/GPAT4/GK/DGKE/DGKZ/AKR1A1/LPIN3/ALDH3A2/AGPAT1/PNPLA2	2.63658894461035
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	12/1706	33/9376	1.99850793989129	BCAT1/IDH3A/PDHA1/IDH1/GPT2/BCAT2/OGDH/IDH3G/IDH3B/DBT/NAGS/GOT1	2.70983462559085
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	37/1706	142/9376	1.43202945692915	NQO1/SQSTM1/CYBA/GSTO1/GSTP1/TXN/MGST1/GSTM3/MMP2/CTSL/RAC2/HMOX1/IL1A/ACTG1/VEGFA/SUMO2/RAC1/IL1B/ICAM1/HSP90B1/TP53/CALM2/MGST3/CALM3/ARHGEF2/ACTB/MAPK9/CCL2/THBD/MGST2/MAP2K7/CAV2/CHUK/TXN2/PIAS4/TNFRSF1A/SUMO1	2.44647096525195
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	21/1706	71/9376	1.62554695110876	ATP6V0E1/ATP6V0B/ATP6V1F/ATP6V1G1/ATP6V0C/CXCL8/CXCL1/RAC1/ATP6V1A/ATP6AP1/ATP6V0A2/CASP3/TCIRG1/MAPK9/GIT1/PLCG1/CXCL3/ATP6V0D1/CHUK/ATP6V1C1/ATP6V1E1	2.49521726626478
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	14/1706	42/9376	1.83196561156702	SLC7A11/PRNP/FTH1/FTL/GCLM/GPX4/HMOX1/SLC39A8/SLC3A2/VDAC3/TP53/LPCAT3/VDAC2/ACSL5	2.54843518249701
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	18/1706	59/9376	1.67671428855286	GCLM/GPX4/GSTO1/GSTP1/MGST1/G6PD/GSTM3/PGD/GGCT/TXNDC12/GSTK1/IDH1/MGST3/SRM/ODC1/GSR/PRDX6/MGST2	2.45906933577513
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	9/1706	23/9376	2.15056832662215	RXYLT1/B4GALT2/POMT2/POMGNT2/POMT1/B4GALT3/CHST10/FUT4/B4GAT1	2.60542355316525
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	14/1706	43/9376	1.78936176013523	ACAT2/ACAT1/ALDH2/ECI2/ECI1/ACADM/ALDH9A1/GCDH/ACADS/ACOX3/CPT1C/ACSL5/ACADVL/ALDH3A2	2.44667986588189
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	32/1706	122/9376	1.44154671074126	PLCB1/HIF1A/ATP1B1/ACTG1/PFKP/ATP1B3/THRA/MAP2K2/MED4/RXRB/MAPK3/CCND1/PRKACA/GATA4/TP53/MED1/ATP1A1/MED24/KRAS/ACTB/PFKL/MED16/MED17/PRKACB/PLCG1/PDPK1/SLC9A1/PLCD4/TSC2/ATP2A2/MED12/NOTCH2	2.31509752818523
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	12/1706	35/9376	1.88430748618322	AKR1B1/TPI1/PFKFB4/ENOSF1/PFKP/HK2/AKR1B10/PMM1/PFKL/HK1/MPI/FCSK	2.47182720261287
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	42/1706	170/9376	1.35780980622026	ITGB1/ARPC1B/TUBA4A/RAB13/RUNX1/ARPC2/MYL12A/ACTG1/RAC1/ACTR3C/ARPC3/NEDD4L/MYL6/HSPA4/CCND1/RAB8A/PRKACA/PRKCI/MYL6B/ARPC1A/GATA4/ARPC4/WHAMM/TUBA1B/ARHGEF2/CLDN11/MICALL2/ACTB/MAPK9/RDX/TUBA1C/PRKAG1/PRKACB/RAPGEF6/SCRIB/MYL12B/MAP2K7/ACTR3/PRKAB1/CLDN14/PCNA/NF2	2.2203359145675
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1706	24/9376	2.0609613130129	HS3ST3A1/HS3ST3B1/HS2ST1/HS6ST3/NDST2/B3GAT3/B3GALT6/EXTL2/EXT2	2.45431549616806
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	31/1706	119/9376	1.43170421744313	MMP14/IL6/CXCL1/CXCL6/IL1B/LIF/CXCL5/CREB1/ICAM1/MAPK3/TRADD/CASP3/XIAP/CREB3L1/MAPK9/RPS6KA4/CCL2/CXCL3/ATF6B/MAP2K7/BIRC3/CHUK/VEGFC/FRMD8/RHBDF1/TNFRSF1A/RHBDF2/BAG4/MMP3/MLKL/TAB2	2.2351265115912
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	14/1706	44/9376	1.74869444740488	MGAT4B/OSTC/RPN2/TUSC3/HEXA/DAD1/MAN1A2/MAGT1/B4GALT2/STT3A/B4GALT3/B4GALNT4/MGAT2/HEXB	2.34758353601682
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	14/1706	44/9376	1.74869444740488	TAF12/TAF11/TAF13/GTF2E2/GTF2H1/TAF9B/TAF10/GTF2H4/GTF2H2C/GTF2F1/TAF6/TBPL1/TAF8/ERCC2	2.34758353601682
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	10/1706	28/9376	1.96282029810752	ATP6V0E1/ATP6V1F/ATP6V1G1/ATP6V0C/ATP6V1A/ATP6V0A2/TCIRG1/ATP6V0D1/ATP6V1C1/ATP6V1E1	2.40625899829707
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	11/1706	32/9376	1.88921453692849	LDHB/SUCLG1/LDHA/MMUT/ACSS2/ACADS/ACOX3/MLYCD/PCCB/DBT/SUCLA2	2.37625256066438
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	35/1706	138/9376	1.39388687836621	SHC3/HK2/SHC1/SREBF1/MAP2K2/MAPK3/PRKACA/PRKCI/GYS1/CALM2/RPS6/MKNK1/CALM3/PRKAR2A/PPP1CC/PPP1CA/TSC1/KRAS/MAPK9/HK1/GRB2/PRKAG1/INPPL1/PRKACB/CRK/EXOC7/PDPK1/G6PC3/EIF4E/CRKL/PRKAB1/TSC2/PRKAR1B/ARAF/PPP1R3E	2.1983637149333
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	39/1706	157/9376	1.36522278059453	HLA-C/SQSTM1/HLA-A/HLA-B/IL6/CXCL8/SLC25A6/IL1A/SLC25A5/CDKN2A/HUS1/MAP2K2/RBBP4/MAPK3/CCND1/GATA4/RAD1/VDAC3/TP53/CALM2/HLA-F/CALM3/ITPR3/PPP1CC/PPP1CA/PPP3R1/PPID/TGFB1/TSC1/KRAS/VDAC2/LIN37/TRPM7/LIN54/CHEK1/VDAC1/PPP3CC/E2F1/TSC2	2.17642270021135
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	53/1706	224/9376	1.30036844749623	HLA-C/B2M/HLA-A/HLA-B/CALR/IL6/FDPS/TSPO/SLC25A6/NRP1/VAC14/SLC25A5/CDKN2A/CDC26/RAN/CREB1/MAP2K2/ICAM1/ANAPC11/MAPK3/CCND1/PRKACA/VDAC3/TP53/HLA-F/NFKB2/GPS2/PPP3R1/CDC16/TGFB1/ADCY8/XIAP/CREB3L1/KRAS/BAX/MAPK9/VDAC2/CANX/KAT5/ANAPC13/XPO1/PRKACB/ANAPC5/CHEK1/ADCY6/ATF6B/VDAC1/PPP3CC/CHUK/E2F1/TBPL1/TNFRSF1A/ANAPC15	2.14584220526911
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	22/1706	79/9376	1.5305029159927	AP2S1/ATP6V0E1/AP2M1/ATP6V0B/ATP6V1F/CLTA/ATP6V1G1/ATP6V0C/SNAP25/ATP6V1A/VAMP2/CLTC/ATP6V0A2/TCIRG1/ATP6V0D1/UNC13A/ATP6V1C1/DNM1/RAB3A/AP2A1/STX3/ATP6V1E1	2.23309590529245
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	45/1706	187/9376	1.32254201904571	PLCB1/CYBA/GABARAP/TXN/IL6/CTSB/CXCL8/CXCL1/IKBKE/IL1B/PANX1/STAT2/SUGT1/MAPK3/VDAC3/PYCARD/TBK1/ITPR3/IRF3/GABARAPL2/GSDMD/ATG12/MFN2/XIAP/RBCK1/MYD88/MAPK9/VDAC2/CCL2/TRIP6/IRF9/TRPM7/CXCL3/SHARPIN/CASP4/IFNAR2/VDAC1/BIRC3/CHUK/PKN1/IRF7/TXN2/NAMPT/TYK2/TAB2	2.10111801955111
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	41/1706	168/9376	1.34126053704014	IL33/SQSTM1/FTH1/FTL/SLC25A6/IL1A/PPIA/CHMP4A/SLC25A5/IL1B/STAT6/STAT2/CHMP1A/PLA2G4C/BID/TRADD/CHMP2B/VDAC3/PYCARD/PARP1/VPS4A/TICAM2/PPID/XIAP/RBCK1/BAX/MAPK9/VDAC2/IRF9/TRPM7/SHARPIN/IFNAR2/SMPD1/VDAC1/BIRC3/CHMP3/CHMP7/TNFRSF1A/TYK2/AIFM1/MLKL	2.10491966303877
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	18/1706	63/9376	1.57025623848602	CETN2/RPA3/POLR2C/POLR2L/RPA2/GTF2H1/RPA1/POLD2/CUL4A/GTF2H4/CUL4B/POLE4/GTF2H2C/ERCC5/ERCC2/POLR2D/PCNA/POLR2J	2.14177077373503
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	15/1706	50/9376	1.64876905041032	SMOX/CNDP2/P4HA1/ALDH2/ALDH18A1/SRM/ALDH9A1/ODC1/PYCR2/P4HA2/AZIN2/OAT/ALDH3A2/PYCR1/GOT1	2.16922644307964
Genetic Information Processing	Transcription	hsa03040	Spliceosome	56/1706	243/9376	1.26654412651547	SRSF9/PRPF38B/SMNDC1/SF3A3/SNRPA1/HSPA8/RBM22/CWC15/SF3A2/LSM6/CDC40/PHF5A/SNRNP27/DHX8/SLU7/ISY1/SART1/PPIH/ZMAT2/SNRPA/THOC7/SF3A1/DDX46/PRPF6/SNRPF/PPIL1/PPIE/NCBP2/PRPF38A/LSM8/U2AF2/LSM2/LSM3/PQBP1/YJU2/TXNL4A/PRPF40A/XAB2/SNRPE/SNRPD3/DDX23/EFTUD2/GPKOW/THOC5/LSM5/CCDC12/DHX38/CTNNBL1/SNRPB2/PRPF4/MAGOHB/SNRNP40/SF3B4/SRSF8/PRPF19/DHX16	1.98537703749647
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	34/1706	137/9376	1.36394519985282	CTSD/TUBA4A/CTSL/CTSB/ACTG1/DDIT3/MAP2K2/BID/MAPK3/TRADD/TP53/PARP1/TUBA1B/ITPR3/CASP3/HTRA2/EIF2S1/XIAP/KRAS/BAX/ACTB/MAPK9/TUBA1C/CTSZ/CYCS/ENDOG/PDPK1/BIRC3/CHUK/PARP2/TNFRSF1A/CASP2/AIFM1/DFFA	2.02377052052304
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	7/1706	18/9376	2.13729321349485	PRDX1/MMADHC/ABCD4/MMUT/MMAB/HCFC1/THAP11	2.27769017994242
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	32/1706	128/9376	1.37397420867526	PDE7B/NME2/AK1/GUK1/LACC1/AK4/APRT/GMPS/HPRT1/PDE4A/NME7/ATIC/GMPR2/ADCY8/NUDT9/AK2/ITPA/PAICS/PGM2/PRUNE1/NME1/NUDT16/PGM1/DGUOK/ADCY6/PPAT/ADPRM/PFAS/PDE6D/ADSL/PRPS1/ADCY10	2.00909371847707
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	21/1706	78/9376	1.47966453241951	ITGB1/IL6/CFL1/CXCL8/IL1A/CXCL6/IL1B/CD14/CXCL5/MAPK3/PYCARD/CALM2/CALM3/TICAM2/CASP3/IRF3/GNAI2/MYD88/MAPK9/IRAK1/C3	2.00616942334931
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	32/1706	130/9376	1.35283614392641	PLCB1/COL1A1/COL3A1/COL1A2/MMP2/MMP1/GNG11/SHC3/GNAS/VEGFA/SHC1/CREB1/MAP2K2/MAPK3/GNG5/PRKACA/TGFB1/GNAI2/ADCY8/CREB3L1/KRAS/MAPK9/GRB2/GNG12/GNG10/PRKACB/ADCY6/ATF6B/MAP2K7/VEGFC/GNB2/GNG2	1.91049219750977
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	6/1706	15/9376	2.19835873388042	HEXA/B3GALT4/SLC33A1/ST6GALNAC4/HEXB/ST3GAL1	2.19052806639999
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	10/1706	31/9376	1.77286994667776	ACAT2/CAT/ACAT1/PGP/MMUT/ACSS2/HYI/PCCB/MDH2/GRHPR	2.03270840830358
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	9/1706	27/9376	1.83196561156702	SCD/FADS1/FADS2/SCP2/HSD17B4/HACD4/ACOX3/TECR/ACOT2	2.04165401631866
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	73/1706	333/9376	1.20480621301254	ITGA2/PKM/HLA-C/COL1A1/FN1/COL1A2/ITGB1/HLA-A/HLA-B/ATP6V0E1/SPP1/ATP6V0B/ATP6V1F/ITGA11/ATP6V1G1/ATP6V0C/ITGA3/GNAS/VEGFA/IKBKE/ATP6V1A/STAT2/CREB1/MAP2K2/ATP6AP1/MAPK3/CCND1/LAMA1/PRKACA/PRKCI/TRADD/BCAP31/TP53/HLA-F/TBK1/ATP6V0A2/CASP3/IRF3/LAMC2/LAMB2/CREB3L1/TSC1/KRAS/BAX/TCIRG1/DVL1/MAML1/GRB2/IRF9/PRKACB/TUBG2/PXN/MX1/THBS2/ATP6V0D1/SCRIB/CHD4/IFNAR2/PPP2R3C/CHUK/ATP6V1C1/E2F1/TBPL1/DVL3/COL6A1/TSC2/LAMA5/TNFRSF1A/TYK2/TUBG1/TADA3/ATP6V1E1/NOTCH2	1.79467762477058
Human Diseases	Infectious disease: viral	hsa05162	Measles	33/1706	136/9376	1.33356320253776	IL6/RACK1/IL1A/IKBKE/IL1B/STAT2/HSPA8/CSNK2A2/BID/CCND1/TRADD/TP53/TBK1/CASP3/IRF3/CSNK2B/EIF2S1/MYD88/BAX/CSNK2A1/MAPK9/CYCS/IRF9/IRAK1/MX1/EIF3H/IFNAR2/CHUK/IRF7/TYK2/IFIH1/TAB2/ADAR	1.84794513530262
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	15/1706	53/9376	1.55544250038709	PLCB1/AP2S1/ATP1B1/AP2M1/CLTA/GNAS/ATP1B3/ATP2B1/PRKACA/CLTC/ATP1A1/PRKACB/ADCY6/DNM1/AP2A1	1.91239090504543
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	14/1706	49/9376	1.57025623848602	GALNT1/GXYLT2/POGLUT1/GALNT9/GALNT12/COLGALT1/GALNT2/B4GALT2/POMT2/POFUT1/GALNT10/POMT1/GALNT5/B4GALT3	1.88744613501412
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	11/1706	36/9376	1.6793018106031	GPI/GBE1/HK2/GAA/GYG1/GYS1/PGM2L1/HK1/PGM2/PGM1/G6PC3	1.92583047152741
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	10/1706	32/9376	1.71746776084408	GABARAP/IGBP1/ATG13/GABARAPL2/BECN1/ATG12/ATG101/ATG4B/PIK3C3/WIPI1	1.91729277142597
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	10/1706	32/9376	1.71746776084408	BID/CASP3/HTRA2/BECN1/XIAP/BAX/MAPK9/CYCS/BIRC3/TNFRSF1A	1.91729277142597
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	49/1706	216/9376	1.24675437453867	PLCB1/CYBA/IL6/MMP1/CXCL8/CXCL1/RAC1/HSPA5/IKBKE/IL1B/CD14/DDIT3/HSPA8/ICAM1/BID/HSPA4/RXRB/MAPK3/HSP90B1/POU2F2/TP53/PYCARD/CALM2/TBK1/CALM3/TICAM2/CASP3/IRF3/EIF2S1/PPP3R1/MYD88/KRAS/BAX/MAPK9/CCL2/ERO1A/CYCS/ARHGEF1/IRAK1/PLCG1/CXCL3/PDPK1/MAP2K7/PPP3CC/CHUK/IRF7/TNFRSF1A/MMP3/TAB2	1.73030024430645
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	26/1706	105/9376	1.36088874002121	CXCL8/CXCL1/IL1B/CD14/BCL10/ICAM1/CSNK2A2/TRADD/PARP1/TRIM25/NFKB2/CARD11/TICAM2/CSNK2B/XIAP/MYD88/CSNK2A1/IRAK1/PLCG1/CXCL3/BIRC3/CHUK/PIAS4/TNFRSF1A/TNFSF13B/TAB2	1.75380845971489
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	12/1706	41/9376	1.60855517113202	MMP2/MMP1/CXCL8/VEGFA/CDKN2A/MAP2K2/MAPK3/CCND1/TP53/KRAS/E2F1/ARAF	1.84167161276348
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	37/1706	158/9376	1.28701381572113	DDIT4/ATP6V1F/ATP6V1G1/LAMTOR1/SLC3A2/ATP6V1A/MAP2K2/LAMTOR5/MAPK3/FLCN/RPS6/RRAGB/NPRL3/TBC1D7/MAPKAP1/LAMTOR4/TSC1/KRAS/DVL1/RRAGC/GRB2/STRADA/NPRL2/PDPK1/LPIN3/EIF4E/AKT1S1/CHUK/ATP6V1C1/LAMTOR3/DVL3/DEPDC5/TSC2/FNIP1/TNFRSF1A/FNIP2/ATP6V1E1	1.7158940318499
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	21/1706	82/9376	1.40748577474051	HLA-C/B2M/HLA-A/HLA-B/CALR/PDIA3/CTSL/CTSB/HSPA5/HSPA8/CREB1/TAPBPL/HSPA4/NFYA/HLA-F/TAPBP/CANX/TAP1/LGMN/PSME3/RFXANK	1.74781520826831
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	34/1706	144/9376	1.2976423081933	SCD/IL6/CXCL8/CXCL1/IKBKE/IL1B/CD14/SREBF1/CCND1/TRADD/ALDH2/TBK1/CASP3/IRF3/ACADM/ALDH9A1/MYD88/MAPK9/PRKAG1/ADIPOR2/IRAK1/CXCL3/ACOX3/MLYCD/CPT1C/MAP2K7/C3/LPIN3/ACADVL/ALDH3A2/CHUK/PRKAB1/TNFRSF1A/TAB2	1.69748318758191
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	25/1706	101/9376	1.36037050363887	PLCB1/COL1A1/COL3A1/FN1/COL1A2/IL6/MMP2/CXCL8/IL1A/VEGFA/RAC1/IL1B/ICAM1/MAPK3/CCND1/CASP3/TGFB1/KRAS/BAX/MAPK9/CCL2/THBD/PLCG1/VEGFC/PLCD4	1.71723777809837
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	12/1706	42/9376	1.57025623848602	CYP1B1/TDO2/ACAT2/CAT/ACAT1/ALDH2/KYNU/ALDH9A1/GCDH/IL4I1/ALDH3A2/KYAT3	1.74678020460357
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	7/1706	21/9376	1.83196561156702	BCAT1/VNN1/ALDH2/BCAT2/AASDHPPT/ALDH3A2/PANK1	1.79999209010396
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	18/1706	70/9376	1.41323061463741	HIF1A/VEGFA/RAC1/ELOB/MAP2K2/MAPK3/FLCN/FH/TGFB1/ELOC/KRAS/GRB2/CRK/PRCC/VHL/CRKL/ARAF/EGLN2	1.63658081108564
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	10/1706	34/9376	1.61644024550031	POLR3D/POLR2C/POLR1D/POLR2L/POLR3GL/POLR1A/POLR3C/POLR1C/POLR2D/POLR2J	1.69819665624469
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	19/1706	75/9376	1.39229386479093	GSTO1/GSTP1/MGST1/GSTM3/CDKN2A/BID/TOP2B/MAPK3/TP53/MSH6/MGST3/CASP3/XIAP/BAX/CYCS/PDPK1/MGST2/POLH/BIRC3	1.6086249310156
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	9/1706	30/9376	1.64876905041032	PIGP/PIGK/PIGV/DPM2/PIGC/PIGG/PIGQ/PIGH/B3GALT4	1.67847675946283
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	18/1706	71/9376	1.39332595809323	SLC16A3/PKM/HIF1A/G6PD/LDHB/PGAM1/PFKP/HK2/MAP2K2/LDHA/PDHA1/MAPK3/IDH1/TP53/KRAS/PFKL/HK1/PDK1	1.56892095815477
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	37/1706	163/9376	1.24753486431864	IL6/CXCL8/IKBKE/STAT6/STAT2/CREB1/MAP2K2/ATP6AP1/BID/MAPK3/YWHAB/VDAC3/TP53/TBK1/TICAM2/CASP3/IRF3/TGFB1/CREB3L1/MYD88/KRAS/BAX/MAPK9/GRB2/CYCS/IRAK1/ATF6B/MAP2K7/CHUK/E2F1/IRF7/TYK2/YWHAQ/IFIH1/ARAF/PCNA/TAB2	1.50351274027213
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	19/1706	76/9376	1.37397420867526	ANGPTL4/PLIN2/ME1/SCD/MMP1/DBI/FADS2/HMGCS1/RXRB/ILK/SCP2/ACADM/PPARD/GK/PDPK1/ACOX3/CPT1C/ACSL5/ACOX2	1.54377656312719
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	26/1706	110/9376	1.29903016092934	GAPDH/HIF1A/IL6/TIMP1/LDHB/HMOX1/ENO1/PFKP/VEGFA/HK2/ELOB/MAP2K2/PGK1/LDHA/PDHA1/MAPK3/RPS6/MKNK1/ELOC/PFKL/HK1/PLCG1/VHL/EIF4E/PDK1/EGLN2	1.48779350635024
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/1706	10/9376	2.19835873388042	SQOR/ETHE1/MPST/TST	1.78808120561789
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	6/1706	18/9376	1.83196561156702	MAN2B2/HEXA/AGA/GBA2/FUCA1/HEXB	1.66620171564451
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	9/1706	31/9376	1.59558295200998	SMOX/CNDP2/ALDH3B1/ALDH2/ALDH9A1/ACADS/ACOX3/MLYCD/ALDH3A2	1.56642974616495
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	20/1706	83/9376	1.32431249028941	IL33/IL6/IKBKE/IL1B/POLR3D/POLR1D/POLR2L/PYCARD/POLR3GL/TBK1/CASP3/IRF3/GSDMD/ZDHHC1/CHUK/IRF7/POLR3C/POLR1C/MLKL/ADAR	1.39959448429426
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	7/1706	23/9376	1.67266425403945	RPA3/MSH6/RPA2/RPA1/POLD2/PCNA/MLH3	1.52322574009311
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	22/1706	94/9376	1.28627372727046	IL6/MMP1/CXCL8/CXCL1/CXCL6/IKBKE/IL1B/CXCL5/MAPK3/HSP90B1/TRADD/TBK1/ELAVL1/CASP3/MAPK9/CCL2/ANAPC5/CXCL3/CHUK/CCL7/MMP3/TAB2	1.31553409093967
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	17/1706	70/9376	1.33471780271311	HLA-C/HLA-A/HLA-B/RAC2/ACTG1/RAC1/EIF4G2/ICAM1/BID/CCND1/LAMA1/HLA-F/CASP3/SGCB/ACTB/CYCS/EIF4G1	1.32563443666846
Cellular Processes	Cell motility	hsa04814	Motor proteins	42/1706	194/9376	1.18983333534765	TUBA4A/TPM2/MYL12A/ACTG1/DYNLL1/DYNLT1/TUBB/KIF26B/TUBB3/CAPZB/DNAH14/MYO1C/MYL5/MYO5B/MYL6/TNNT1/MYL6B/TPM4/TUBA1B/ACTR1A/DYNLT3/DCTN2/MYO19/MYO1B/ACTB/TUBA1C/KIF3A/DNAL4/DCTN4/KLC2/CAPZA1/TUBG2/CAPZA2/TUBB6/MYL12B/DYNC1H1/BICDL2/TUBG1/DCTN5/KIF7/ACTR10/KIFC3	1.26003372343921
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	18/1706	75/9376	1.31901524032825	PLCB1/ATP1B1/GNAS/ATP1B3/HSPA5/CREB1/PRKACA/HSP90B1/ITPR3/ADCY8/CREB3L1/ATP1A1/TTF1/CANX/GSR/PRKACB/ADCY6/ATF6B	1.30814145981979
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	34/1706	154/9376	1.21337982064828	NQO1/GCLM/NME2/TDO2/AK1/AK4/QPRT/BCAT1/ALDH2/NME7/KYNU/MAT2A/GGH/AK2/MMAB/PDXP/PPOX/PMM1/UMPS/NME1/NFS1/MTHFD1/AKR1A1/COQ2/BCAT2/NMNAT1/COQ4/ALDH3A2/PANK1/PDXK/MPI/ADSL/UROS/FPGS	1.25915332567113
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	18/1706	76/9376	1.30165977663972	PLCB1/ATP1B1/GNAS/ACTG1/ATP1B3/SLC4A2/PRKACA/CALM2/CALM3/ITPR3/GNAI2/ADCY8/ATP1A1/ACTB/KCNJ15/PRKACB/ADCY6/SLC9A1	1.24526045489669
NA	NA	hsa03272	Virion - Hepatitis viruses	12/1706	48/9376	1.37397420867526	DPP4/CD9/CD63/CHMP4A/LAMP1/CHMP1A/TSG101/VPS4A/LAMP2/CLDN11/CHMP7/CLDN14	1.22502646606759
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	22/1706	97/9376	1.2464920656023	PLCB1/GNG11/GNAS/GRIA4/GRIA3/CREB1/MAPK3/GNG5/PRKACA/CALM2/CALM3/ITPR3/GNAI2/ADCY8/GNG12/GNG10/PRKACB/ADCY6/KCNJ6/GNB2/GNG2/ADCY10	1.15084197493066
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	24/1706	107/9376	1.23272452367126	PLCB1/PKM/LDHB/PGAM1/GNAS/PFKP/PPP4C/CREB1/LDHA/PDHA1/PRKACA/GYS1/CALM2/CALM3/ITPR3/PPP3R1/CREB3L1/PFKL/PRKAG1/PRKACB/G6PC3/CPT1C/PPP3CC/PRKAB1	1.14181322130163
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	17/1706	73/9376	1.27986638616326	PPIA/CHMP4A/RAN/MAP1A/TSG101/FEZ1/VPS4A/CDK9/NELFCD/SMARCB1/TRIM5/XPO1/NELFE/MX1/APOBEC3C/HGS/NELFB	1.13208263583962
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	8/1706	30/9376	1.46557248925361	IL6/ABCC3/IL1B/ATIC/GGH/CHUK/FPGS/TYMS	1.20451584822553
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	22/1706	98/9376	1.23377275881044	ARPC1B/CFL1/RAC2/ARPC2/RAC1/ACTR3C/PLPP2/ARPC3/PLA2G4C/MAPK3/ARPC1A/ARPC4/BIN1/ARF6/INPPL1/CRK/PLCG1/CRKL/LIMK2/ACTR3/LIMK1/MARCKSL1	1.09712781451959
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	24/1706	109/9376	1.21010572507179	IL6/SPP1/CXCL8/RAC1/IKBKE/IL1B/CD14/STAT2/MAP2K2/MAPK3/TBK1/TICAM2/IRF3/MYD88/MAPK9/TOLLIP/IRF9/IRAK1/MAP2K7/IFNAR2/CHUK/IRF7/TYK2/TAB2	1.04054058393579
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	36/1706	170/9376	1.16383697676022	NQO1/GSTO1/GSTP1/MGST1/GSTM3/HMOX1/SHC3/ACTG1/CDKN2A/SMARCC2/SHC1/SMARCE1/MAP2K2/MAPK3/CCND1/BRD7/ARID2/TP53/MGST3/TGFB1/SMARCD1/SMARCD2/KRAS/BAX/ACTB/DVL1/SMARCB1/GRB2/PLCG1/TXNRD3/MGST2/E2F1/DVL3/TXNRD2/ARAF/ACTL6A	1.01666616540675
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	22/1706	99/9376	1.22131040771135	SLC22A3/HIF1A/RAC2/DGKI/RAC1/PLPP2/MAP2K2/PLA2G4C/MAPK3/PCYT1A/LYPLA1/SLC44A1/TSC1/KRAS/MAPK9/GRB2/DGKE/DGKZ/PLCG1/PDPK1/SLC22A4/TSC2	1.04398227917821
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	20/1706	90/9376	1.22131040771135	CREB1/CAT/PRKACA/TP53/ATG13/ADCY8/CREB3L1/TSC1/KRAS/BAX/ATG101/PRKAG1/ADIPOR2/PRKACB/ADCY6/ATF6B/EIF4E/AKT1S1/PRKAB1/TSC2	0.994915559731405
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	9/1706	36/9376	1.37397420867526	GALNT1/GALNT9/GALNT12/GALNT2/GALNT10/GCNT3/GALNT5/ST6GALNAC4/ST3GAL1	1.06022229793964
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	9/1706	36/9376	1.37397420867526	RPA3/RPA2/RPA1/POLD2/RNASEH2B/MCM3/POLE4/PCNA/POLA2	1.06022229793964
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	6/1706	22/9376	1.49888095491847	CNDP2/ALDH3B1/ALDH2/ALDH9A1/ALDH3A2/CARNMT1	1.1048086149301
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	7/1706	27/9376	1.4248621423299	ACAT2/HMGCS1/ACAT1/HMGCL/BDH1/ACADS/AACS	1.04261701109953
Organismal Systems	Digestive system	hsa04978	Mineral absorption	14/1706	61/9376	1.2613533718986	MT2A/FTH1/FTL/ATP1B1/HMOX1/ATOX1/ATP1B3/ATP2B1/STEAP1/SLC39A4/ATP1A1/STEAP2/TRPM7/HMOX2	0.965781907181274
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	26/1706	122/9376	1.17125670247727	SCD/PFKFB4/PFKP/EEF2/SREBF1/CREB1/CCND1/RAB8A/GYS1/RAB11B/ELAVL1/CREB3L1/TSC1/PFKL/PRKAG1/ADIPOR2/STRADA/HMGCR/PDPK1/MLYCD/G6PC3/CPT1C/AKT1S1/PPP2R3C/PRKAB1/TSC2	0.897925313325728
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	42/1706	205/9376	1.12598861979241	HLA-C/B2M/HLA-A/HLA-B/CALR/IL6/PDIA3/PSMD2/ADRM1/RAC1/PSMD8/IKBKE/STAT2/ICAM1/BID/TAPBPL/CCND1/TRADD/SAP30L/TP53/HLA-F/NFKB2/TBK1/TAPBP/CASP3/IRF3/MYD88/BAX/MAPK9/PSMC5/CYCS/IRF9/TAP1/IRAK1/MAP2K7/IFNAR2/CHUK/E2F1/IRF7/TYK2/PSMD12/TAB2	0.86015629432184
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	18/1706	82/9376	1.20641637834901	GSTO1/GSTP1/NME2/MGST1/GSTM3/GMPS/HPRT1/NME7/MGST3/TPMT/UCKL1/DUT/ITPA/UMPS/NME1/UCK1/UPP1/MGST2	0.885374920250432
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	17/1706	77/9376	1.21337982064828	RAC2/VEGFA/RAC1/CDKN2A/RALB/MAPK3/CCND1/TP53/RALBP1/TGFB1/RALA/KRAS/BAX/MAPK9/CHUK/E2F1/ARAF	0.886661914217214
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	17/1706	77/9376	1.21337982064828	RUNX1/SHC3/CDKN2A/SHC1/MAP2K2/MAPK3/CCND1/TP53/TGFB1/KRAS/BAX/GRB2/CRK/CRKL/CHUK/E2F1/ARAF	0.886661914217214
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	15/1706	67/9376	1.23042466448531	PLCB1/MAP2K2/MAPK3/PRKACA/CALM2/CALM3/ITPR3/PPP1CC/PPP1CA/PPP3R1/ADCY8/KRAS/PRKACB/PPP3CC/ARAF	0.892672836468281
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	22/1706	103/9376	1.17388087731479	PLCB1/PRDX1/COL1A1/COL3A1/FN1/COL1A2/IL6/CXCL8/GNAS/CXCL1/IL1B/CD14/LAMA1/PRKACA/CASP3/LAMC2/TGFB1/LAMB2/PRKACB/CXCL3/RAB5B/LAMA5	0.836831028529359
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	21/1706	98/9376	1.17769217886451	PLCB1/SYNJ2/DGKI/PI4KB/CALM2/PI4K2A/CALM3/ITPR3/PIP4K2B/CDIPT/DGKE/INPPL1/DGKZ/PLCG1/PIP4P2/IPPK/PLCD4/PIK3C3/MTMR4/MTMR14/PIP4P1	0.833933914485418
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	37/1706	181/9376	1.12347062366817	CTSD/IL6/ATP6V0B/ATP6V0C/IL1A/IL1B/CD14/LAMP1/CREB1/BCL10/ATP6AP1/BID/MAPK3/TRADD/CALM2/NFYA/MRC2/CALM3/ATP6V0A2/CASP3/PPP3R1/TGFB1/LAMP2/MYD88/BAX/TCIRG1/MAPK9/CYCS/IRAK1/RAB5B/IL10RB/ATP6V0D1/C3/PPP3CC/PIK3C3/TNFRSF1A/RFXANK	0.791051087869877
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1706	14/9376	1.57025623848602	B4GALT2/CHST1/B4GALT3/ST3GAL1	1.00699476808697
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	29/1706	140/9376	1.13843577290236	PLCB1/SPP1/GNG11/MAP2K2/MAPK3/CCND1/GNG5/PRKACA/CALM2/RPS6/CALM3/ITPR3/GNAI2/ADCY8/BECN1/KRAS/NRF1/PRKAG1/TFAM/GNG12/GNG10/PRKACB/ADCY6/SLC9A1/PRKAB1/GNB2/PIK3C3/GNG2/ADCY10	0.778301477899209
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	21/1706	99/9376	1.16579629826992	MMP2/SHC3/GNAS/CDKN2A/SHC1/MAP2K2/MAPK3/CCND1/PRKACA/TP53/MED1/ADCY8/KRAS/BAX/MAPK9/GRB2/PRKACB/ADCY6/E2F1/ARAF/NOTCH2	0.782106901962341
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/1706	19/9376	1.4462886407108	HEXA/GALNS/ARSB/SGSH/HEXB	0.918336378039601
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	19/1706	89/9376	1.17328134673393	PLCB1/TUBA4A/GNAS/TUBB/TUBB3/MAP2K2/MAPK3/PRKACA/CSNK1D/TUBA1B/ITPR3/GNAI2/ADCY8/KRAS/TUBA1C/GRB2/PRKACB/TUBB6/ADCY6	0.774616181094057
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	37/1706	183/9376	1.11119225619639	NOP10/RAN/FBL/GNL3/CSNK2A2/GTPBP4/RRP7A/NAT10/WDR75/RPP25/XRN2/MPHOSPH10/WDR36/CSNK2B/UTP4/EMG1/LSG1/RPP30/NOP56/GAR1/BMS1/CSNK2A1/POP4/IMP3/POP5/DKC1/RPP25L/NOB1/XPO1/WDR3/UTP18/NVL/TCOF1/EFL1/RPP40/REXO1/IMP4	0.716389030163614
Organismal Systems	Endocrine system	hsa04924	Renin secretion	15/1706	69/9376	1.19476018145675	PLCB1/CTSB/GNAS/CREB1/ORAI1/PRKACA/CALM2/CALM3/ITPR3/PPP3R1/GNAI2/PRKACB/ADCY6/CLCA2/PPP3CC	0.765768201914308
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	13/1706	59/9376	1.2109603195104	NME2/DCTD/NT5C3A/NME7/UCKL1/DUT/UMPS/NME1/UCK1/UPP1/DCTPP1/ASMTL/TYMS	0.76659538825864
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	8/1706	34/9376	1.29315219640025	CREB1/SKP1/CSNK1D/CUL1/BHLHE41/PRKAG1/DBP/PRKAB1	0.807588542979774
Organismal Systems	Immune system	hsa04611	Platelet activation	26/1706	126/9376	1.13407395001768	PLCB1/ITGA2/COL1A1/COL3A1/COL1A2/ITGB1/GNAS/MYL12A/ACTG1/VAMP8/ORAI1/PLA2G4C/MAPK3/PRKACA/PRKCI/PTGS1/ITPR3/PPP1CC/PPP1CA/GNAI2/ADCY8/ACTB/PRKACB/ARHGEF1/ADCY6/MYL12B	0.714556016601865
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	41/1706	205/9376	1.09917936694021	PKM/HLA-C/HLA-A/HLA-B/VAC14/RAC1/CDKN2A/CREB1/MAPK3/CCND1/PRKACA/YWHAB/TRADD/VDAC3/GTF2E2/TP53/HLA-F/NFKB2/CASP3/IRF3/GTF2H1/CREB3L1/KRAS/BAX/GRB2/IRF9/GTF2H4/PRKACB/PXN/CHEK1/GTF2H2C/ATP6V0D1/SCRIB/ATF6B/CHD4/C3/SP100/TBPL1/IRF7/YWHAQ/HPN	0.677122718552207
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	24/1706	116/9376	1.13708210373125	PLCB1/GNG11/HOMER3/GNAS/GRIA4/GRIA3/PLA2G4C/MAPK3/GNG5/PRKACA/NCDN/ITPR3/PPP3R1/GNAI2/ADCY8/SHANK1/GNG12/GNG10/PRKACB/ADCY6/PPP3CC/GNB2/GNG2/DLG4	0.700618711078616
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	4/1706	15/9376	1.46557248925361	AK1/AK4/AK2/NFS1	0.851038654636716
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	12/1706	55/9376	1.19910476393478	PSAP/PLPP2/ASAH1/HEXA/CERS5/KDSR/ARSA/CERS2/CERK/GBA2/SMPD1/HEXB	0.698408010313705
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	31/1706	154/9376	1.10631689529697	PLCB1/GNAS/ACTG1/CACNG8/EEF2/MAP2K2/PLA2G4C/MYL6/MAPK3/CCND1/PRKACA/MYL6B/CALM2/CALM3/ITPR3/PPP1CC/PPP1CA/PPP3R1/GNAI2/ADCY8/KRAS/ACTB/PRKAG1/PRKACB/ADCY6/KCNJ14/CACNB3/PPP3CC/KCNJ6/PRKAB1/CACNA2D1	0.627375502901284
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	28/1706	139/9376	1.10708713217	PLCB1/CTSD/MMP2/SHC3/GNAS/KRT19/SHC1/HSPA8/CREB1/MAP2K2/FKBP4/MAPK3/EBAG9/PRKACA/HSP90B1/CALM2/CALM3/ITPR3/GNAI2/KRT10/ADCY8/CREB3L1/KRAS/GRB2/PRKACB/ADCY6/ATF6B/KCNJ6	0.599869368870626
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	18/1706	87/9376	1.13708210373125	RAC2/RAC1/AREG/RALB/MAP2K2/MAPK3/CCND1/TP53/MSH6/CASP3/TGFB1/RALA/KRAS/BAX/MAPK9/GRB2/CYCS/ARAF	0.605805727826389
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	40/1706	203/9376	1.08293533688691	ITGA2/COL1A1/FN1/COL1A2/ITGB1/SPP1/ITGA11/RAC2/ITGA3/SHC3/MYL12A/ACTG1/VEGFA/RAC1/SHC1/MYL5/MAPK3/CCND1/LAMA1/ILK/LAMC2/PPP1CC/PPP1CA/XIAP/LAMB2/PARVB/ACTB/MAPK9/GRB2/CRK/PXN/PDPK1/THBS2/MYL12B/CRKL/BIRC3/CAV2/VEGFC/COL6A1/LAMA5	0.563390351349181
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	12/1706	56/9376	1.17769217886451	CCND1/PRKACA/CSNK1D/CUL1/KIF3A/PRKACB/IQCE/GPR161/MEGF8/CDON/CSNK1G1/KIF7	0.628972763720328
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	15/1706	72/9376	1.14497850722939	CXCL8/IKBKE/AZI2/SIKE1/TRADD/TRIM25/TBK1/IRF3/ATG12/MAPK9/IFNE/CHUK/IRF7/IFIH1/ADAR	0.582388097741272
Organismal Systems	Digestive system	hsa04970	Salivary secretion	19/1706	93/9376	1.12281763289591	PLCB1/ATP1B1/GNAS/ATP1B3/ATP2B1/AQP5/BST1/SLC4A2/VAMP2/PRKACA/CALM2/CALM3/ITPR3/SLC12A2/ADCY8/ATP1A1/PRKACB/ADCY6/SLC9A1	0.561352280769056
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	19/1706	93/9376	1.12281763289591	ITGA2/FN1/ITGB1/ITGA3/RXRB/ZBTB17/CCND1/LAMA1/TP53/CASP3/LAMC2/XIAP/LAMB2/BAX/CYCS/BIRC3/CHUK/E2F1/LAMA5	0.561352280769056
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/1706	16/9376	1.37397420867526	MIF/ALDH3B1/IL4I1/GOT1	0.706059317385756
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1706	16/9376	1.37397420867526	HEXA/NAGA/HEXB/ST3GAL1	0.706059317385756
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	21/1706	105/9376	1.09917936694021	ITGA2/ITGB1/ITGA11/ITGA3/TPM2/GNAS/ACTG1/CACNG8/LAMA1/PRKACA/TPM4/EMD/TGFB1/ADCY8/SGCB/ACTB/PRKACB/ADCY6/CACNB3/ATP2A2/CACNA2D1	0.481981268683209
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1706	37/9376	1.18830201831374	TPR/MAP2K2/RXRB/MAPK3/CCND1/TP53/KRAS/BAX	0.541231567464856
NA	NA	hsa04517	IgSF CAM signaling	57/1706	299/9376	1.04771277450823	CDH2/ITGB1/ARPC1B/TUBA4A/GRIP1/ARPC2/CADM3/MYL12A/ACTG1/DYNLL1/NRP1/RAC1/TUBB/ACTR3C/ARPC3/TUBB3/SLITRK4/MAP2K2/ICAM1/MYL6/SLIT3/MAPK3/PRKCI/MYL6B/NECTIN3/ARPC1A/NLGN2/ARPC4/NCK1/TUBA1B/PPFIA4/BAIAP2/UNC5B/KIRREL3/ACTB/MAPK9/APP/RDX/TUBA1C/GRB2/ROBO2/ARF6/CNTNAP1/PXN/GIT1/PLCG1/MTSS1/TUBB6/PDPK1/CASK/CASKIN2/RAPGEF6/MYL12B/ACTR3/LRRC4B/PPFIA1/NECTIN1	0.395436330782397
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	30/1706	154/9376	1.07062925351319	PLCB1/ATP1B1/SCN1B/TPM2/GNAS/POPDC3/CACNG8/ATP1B3/ATP2B1/CREB1/MAPK3/PRKACA/CALM2/TPM4/CALM3/PPP1CC/PPP1CA/GNAI2/ADCY8/CREB3L1/ATP1A1/CREM/PRKACB/ADCY6/SLC9A1/ATF6B/CACNB3/PPP2R3C/ATP2A2/CACNA2D1	0.416782895311335
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	14/1706	69/9376	1.11510950269297	GNAS/GRIA4/GRIA3/CREB1/PRKACA/CALM2/CALM3/PPP1CC/PPP1CA/PPP3R1/CREB3L1/PRKACB/ATF6B/PPP3CC	0.452593524205656
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/1706	17/9376	1.29315219640025	TXNRD3/SEPHS1/TXNRD2/KYAT3	0.570532461064088
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1706	17/9376	1.29315219640025	PCDH7/PCDH20/LAMP1/LAMP2	0.570532461064088
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1706	12/9376	1.37397420867526	NQO1/COQ2/COQ4	0.611334692316659
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	22/1706	112/9376	1.07955116395914	ITGB1/HSPA8/MAPK3/LAMA1/CASP3/LAMC2/TGFB1/GNAI2/XIAP/LAMB2/MYD88/MAPK9/CYCS/IRAK1/PDPK1/IL10RB/BIRC3/CHUK/LAMA5/TNFRSF1A/TYK2/TAB2	0.399423622609938
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	8/1706	38/9376	1.15703091256864	QPRT/BST1/SIRT2/SIRT5/NMNAT1/NAMPT/NUDT13/SARM1	0.457432995319218
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/1706	75/9376	1.09917936694021	CD82/CDKN2A/BID/SHISA5/CCND1/TP53/CASP3/BAX/CYCS/ZMAT3/CHEK1/GORAB/TP53I3/TSC2/AIFM2	0.406691046232377
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	20/1706	102/9376	1.07762683033354	PLCB1/RAB27B/ATP1B1/GNAS/ATP1B3/RAC1/ATP2B1/PRSS3/BST1/SLC4A2/RAB8A/ITPR3/SLC12A2/ADCY8/ATP1A1/ADCY6/SLC9A1/SLC4A4/CLCA2/ATP2A2	0.371754182301114
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	17/1706	86/9376	1.08639821151067	PLCB1/ATP1B1/GNAS/SNAP25/ATP1B3/CREB1/PCLO/VAMP2/PRKACA/ITPR3/ADCY8/CREB3L1/ATP1A1/PRKACB/ADCY6/ATF6B/RAB3A	0.379597716044518
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	30/1706	156/9376	1.05690323744251	IKBKE/STAT2/MAP2K2/BID/MAPK3/CCND1/YWHAB/TRADD/TP53/TBK1/CASP3/IRF3/EIF2S1/CLDN11/KRAS/BAX/GRB2/CYCS/IRF9/MX1/PSME3/IFNAR2/CHUK/E2F1/IRF7/TNFRSF1A/CLDN14/TYK2/YWHAQ/ARAF	0.337995784727233
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/1706	28/9376	1.17769217886451	AKR1B1/CBR1/GGH/AKR1B10/AKR1C3/FPGS	0.444084327220941
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	44/1706	232/9376	1.04232526175365	ITGA2/PFN1/FN1/ITGB1/ARPC1B/BDKRB1/CFL1/ITGA11/BRK1/RAC2/ARPC2/ITGA3/MYL12A/ACTG1/TMSB4X/RAC1/ACTR3C/ARPC3/PFN2/MYL5/MAP2K2/MAPK3/ARPC1A/ARPC4/PIP4K2B/PPP1CC/PPP1CA/BAIAP2/KRAS/ACTB/RDX/FGF5/GNG12/ARHGEF1/CRK/PXN/GIT1/SLC9A1/MYL12B/CRKL/LIMK2/ACTR3/LIMK1/ARAF	0.307859816377848
Human Diseases	Cancer: specific types	hsa05214	Glioma	15/1706	76/9376	1.0847164805331	SHC3/CDKN2A/SHC1/MAP2K2/MAPK3/CCND1/TP53/CALM2/CALM3/KRAS/BAX/GRB2/PLCG1/E2F1/ARAF	0.349712130205187
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	20/1706	103/9376	1.06716443392254	PNN/RNPS1/CPSF2/PABPN1/SMG7/PPP1CC/PPP1CA/HBS1L/SMG5/NCBP2/CPSF3/UPF3A/RNMT/CPSF4/MAGOHB/UPF3B/NUDT21/PPP2R3C/CSTF2T/CPSF1	0.323240158365631
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1706	18/9376	1.22131040771135	MECR/ACSF3/ACSL5/MCAT	0.443224787048697
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	18/1706	93/9376	1.06372196800666	PLCB1/MMP14/MMP2/GNAS/MAP2K2/PLA2G4C/MAPK3/PRKACA/CALM2/CALM3/ITPR3/ADCY8/KRAS/MAPK9/GRB2/PRKACB/ADCY6/MAP2K7	0.291248668714726
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1706	13/9376	1.26828388493101	POLL/LIG4/PRKDC	0.456495205633661
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	20/1706	104/9376	1.05690323744251	DGKI/PLPP4/GPAM/PLPP2/PLA2G4C/GNPAT/PCYT1A/LYPLA1/LPCAT3/GPAT4/CDIPT/DGKE/PLD3/DGKZ/ADPRM/LPIN3/AGPAT1/PCYT2/SELENOI/CRLS1	0.275197448862776
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	22/1706	115/9376	1.05138895968194	PLCB1/MMP14/GNAS/MMP16/CREB1/RXRB/MAPK3/PDE4A/PRKACA/RUNX2/ITPR3/GNAI2/ADCY8/CREB3L1/MMP15/OXSR1/PRKACB/ARHGEF1/ADCY6/BGLAP/ATF6B/ARAF	0.261497338876002
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	19/1706	99/9376	1.05476807938707	ITGA2/ITGB1/IL6/ITGA11/ITGA3/TPM2/ACTG1/CACNG8/LAMA1/TPM4/EMD/TGFB1/SGCB/ACTB/PRKAG1/CACNB3/PRKAB1/ATP2A2/CACNA2D1	0.258356147530593
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	15/1706	78/9376	1.05690323744251	PLCB1/TPI1/SYNJ2/PI4KB/INPP5K/PI4K2A/PIP4K2B/CDIPT/INPPL1/PLCG1/IPPK/PLCD4/PIK3C3/MTMR4/MTMR14	0.237994530199928
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	26/1706	138/9376	1.03545882392918	CDC26/SMC3/SKP1/ANAPC11/MAPK3/PRKACA/YWHAB/CALM2/CALM3/ITPR3/PPP1CC/PPP1CA/PPP3R1/CDC16/ADCY8/CUL1/CPEB1/ANAPC13/PRKACB/ANAPC5/ADCY6/PPP3CC/SPDYE2/MAD2L2/YWHAQ/ANAPC15	0.197902992411068
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	25/1706	133/9376	1.03306331479343	PLCB1/GNG11/GNAS/GRIA4/GRIA3/CREB1/GNG5/PRKACA/CALM2/CALM3/ITPR3/PPP1CC/PPP1CA/GNAI2/CREB3L1/MAPK9/GNG12/GNG10/PRKACB/ATF6B/PPP2R3C/PPP3CC/KCNJ6/GNB2/GNG2	0.181110323212292
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	8/1706	41/9376	1.07237011408801	RPA3/ABRAXAS1/RPA2/RPA1/POLD2/MUS81/RAD51D/PALB2	0.219013806883633
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/1706	52/9376	1.05690323744251	CYP1B1/GNAS/PLA2G4C/PRKACA/ADCY8/AKR1C3/PRKACB/ADCY6/HSD17B7/ACOT2	0.194050597720052
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	12/1706	63/9376	1.04683749232401	SMYD3/PLOD2/ACAT2/ACAT1/ALDH2/COLGALT1/ALDH9A1/SETDB1/GCDH/KMT2D/ALDH3A2/SETD1B	0.175912450236289
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	16/1706	86/9376	1.02249243436299	CDH2/ITGA2/ITGB1/DSG2/ITGA11/ITGA3/ACTG1/CACNG8/DSC2/LAMA1/EMD/SGCB/ACTB/CACNB3/ATP2A2/CACNA2D1	0.098822377954158
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	13/1706	70/9376	1.02066655501591	CYP1B1/GSTO1/GSTP1/MGST1/GSTM3/CBR1/EPHX1/GSTK1/HSD11B1/MGST3/SULT1A1/MGST2/AKR1C2	0.0818489389997435
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	7/1706	37/9376	1.03976426602452	GFPT1/GPT2/NIT2/IL4I1/PPAT/ADSL/GOT1	0.114293390067036
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	22/1706	120/9376	1.00758108636186	BEX3/SHC3/IRAK3/RAC1/SHC1/MAP2K2/MAPK3/TP53/CALM2/CALM3/ZNF274/KRAS/BAX/MAPK9/GRB2/IRAK1/MAGED1/CRK/PLCG1/PDPK1/MAP2K7/CRKL	0.0394173899457398
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	18/1706	98/9376	1.00945043902672	PLCB1/ATP1B1/GNAS/ATP1B3/ATP2B1/CREB1/ORAI1/PRKACA/CALM2/CALM3/ITPR3/ADCY8/CREB3L1/ATP1A1/PRKACB/PRKD2/ADCY6/ATF6B	0.0443522143828918
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	21/1706	115/9376	1.00359855242367	PLCB1/GNG11/GNAS/HTR7/PLA2G4C/MAPK3/GNG5/PRKACA/PTGS1/ITPR3/CASP3/GNAI2/KRAS/APP/GNG12/GNG10/PRKACB/KCNJ6/GNB2/GNG2/ARAF	0.0183115573543405
NA	NA	hsa04518	Integrin signaling	28/1706	154/9376	0.999253969945646	ITGA2/COL1A1/FN1/COL1A2/ITGB1/SPP1/FRAS1/ITGA11/RAC2/ITGA3/ACTG1/VEGFA/RAC1/ICAM1/CCND1/LAMA1/ILK/LAMC2/TGFB1/LAMB2/PARVB/ACTB/PXN/THBS2/C3/VEGFC/COL6A1/LAMA5	-0.00440231986856114
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	37/1706	204/9376	0.996804818058525	ITGA2/COL1A1/HIF1A/FN1/COL1A2/ITGB1/PLAUR/MMP2/CTSL/CD63/ACTG1/VEGFA/RAC1/MAP2K2/MAPK3/CCND1/PRKACA/TP53/RPS6/ITPR3/CASP3/PPP1CC/PPP1CA/TGFB1/TWIST1/KRAS/ACTB/RDX/GRB2/PRKACB/ARHGEF1/PXN/PLCG1/PDPK1/SLC9A1/CAV2/ARAF	-0.0217598613262852
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	20/1706	110/9376	0.999253969945646	CDC26/ANAPC11/MAPK3/PRKACA/CDC16/GNAI2/FZR1/ADCY8/STK10/KRAS/MAPK9/CPEB1/ANAPC13/PRKACB/ANAPC5/ADCY6/SPDYE2/MAD2L2/ARAF/ANAPC15	-0.00371179504756247
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	11/1706	60/9376	1.00758108636186	RAC2/VEGFA/RAC1/MAP2K2/PLA2G4C/MAPK3/PPP3R1/KRAS/PXN/PLCG1/PPP3CC	0.0277824025026932
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1706	38/9376	1.01240204849756	ATP1B1/ATP1B3/NEDD4L/MAPK3/ATP1A1/KRAS/PDPK1	0.0361273210448578
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	22/1706	122/9376	0.991063363634616	PLCB1/SHC3/GNAS/SHC1/CREB1/MAP2K2/MAPK3/PRKACA/ITPR3/GNAI2/ADCY8/CREB3L1/KRAS/MAPK9/GRB2/PRKACB/CRK/PLCG1/ADCY6/ATF6B/CRKL/ADCY10	-0.0468561632472745
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	8/1706	44/9376	0.999253969945646	CPE/HLA-C/HLA-A/HLA-B/PTPRN/IL1A/IL1B/HLA-F	-0.0023392291462086
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	16/1706	89/9376	0.988026397249628	ITGA2/COL1A1/FN1/COL1A2/ITGB1/SPP1/FRAS1/ITGA11/ITGA3/LAMA1/LAMC2/SV2A/LAMB2/THBS2/COL6A1/LAMA5	-0.053525359833865
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/1706	50/9376	0.98926143024619	IL6/GYPC/CXCL8/IL1B/ICAM1/TGFB1/MYD88/CCL2/THBS2	-0.0359055190072451
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	13/1706	73/9376	0.978721354124845	CDKN2A/MAP2K2/RXRB/MAPK3/CCND1/TP53/KRAS/BAX/GRB2/PLCG1/PDPK1/E2F1/ARAF	-0.0860738791810124
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	11/1706	62/9376	0.975078470672768	HSPA8/CAT/PRKACA/ADCY8/SOD1/KRAS/PRKAG1/PRKACB/ADCY6/AKT1S1/PRKAB1	-0.0928495679444175
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	14/1706	79/9376	0.973956401086263	CYP1B1/GSTO1/GSTP1/MGST1/GSTM3/CBR1/AKR1C1/EPHX1/GSTK1/ALDH3B1/HSD11B1/MGST3/MGST2/CBR3	-0.10962777458917
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/1706	28/9376	0.98141014905376	PPT1/MECR/HACD4/TECR/ACOT2	-0.0464593405480909
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	12/1706	68/9376	0.969864147300186	RUNX1/CD14/MAP2K2/MAPK3/CCND1/DUSP6/PPARD/KRAS/GRB2/PML/CHUK/ARAF	-0.117621638003927
Human Diseases	Substance dependence	hsa05032	Morphine addiction	16/1706	91/9376	0.96631153137601	PDE7B/GNG11/GNAS/PDE4A/GNG5/PRKACA/GNAI2/ADCY8/GABRE/GNG12/GNG10/PRKACB/ADCY6/KCNJ6/GNB2/GNG2	-0.152295994593284
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	22/1706	125/9376	0.967277842907386	PLCB1/CTSD/RAC2/RAC1/ASAH1/MAP2K2/NSMAF/BID/MAPK3/TRADD/TP53/CERS5/GNAI2/KRAS/BAX/MAPK9/CERS2/PDPK1/ORMDL3/SMPD1/PPP2R3C/TNFRSF1A	-0.173692097986211
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	25/1706	142/9376	0.967587470898073	SQSTM1/CYBA/IL1A/RAC1/IL1B/STAT2/CREB1/MAPK3/SIRPA/NFKB2/TNFRSF11B/ITPR3/PPP3R1/TGFB1/MAPK9/GRB2/IRF9/MAP2K7/IFNAR2/PPP3CC/CHUK/TNFRSF1A/TYK2/ATP2A2/TAB2	-0.183543760932145
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	11/1706	63/9376	0.959601034630343	GPX4/PTGIS/CBR1/PTGDS/PTGR1/PLA2G4C/PTGS1/LTA4H/AKR1C3/PTGR2/CBR3	-0.151730603680168
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	8/1706	46/9376	0.955808145165401	FTH1/FTL/HMOX1/FXN/MMAB/PPOX/UROS/HMOX2	-0.141696066353993
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	53/1706	300/9376	0.97094177413052	DUSP4/RAC2/IL1A/MAP4K4/VEGFA/CACNG8/RAC1/EFNA5/AREG/IL1B/CD14/DDIT3/HSPA8/MAP2K2/PLA2G4C/MAPK3/PRKACA/TRADD/TP53/MKNK1/NFKB2/DUSP6/CASP3/PPP3R1/TGFB1/MAP3K12/MYD88/KRAS/MAPKAPK5/MAPK9/MAP3K10/RPS6KA4/GRB2/FGF5/GNG12/STMN1/PRKACB/IRAK1/CRK/CACNB3/DUSP3/MAP3K9/MAP2K7/CRKL/PPP3CC/CHUK/VEGFC/LAMTOR3/TNFRSF1A/ARAF/MAPK8IP1/CACNA2D1/TAB2	-0.241245904116201
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1706	17/9376	0.969864147300186	SCP2/HSD17B4/ACOX2	-0.0586503612056
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1706	23/9376	0.955808145165401	ATP1B1/ATP1B3/ATP1A1/SLC4A4	-0.100070979515097
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	16/1706	93/9376	0.945530638228139	RAC2/MYL12A/ACTG1/RAC1/HEG1/MYL5/CSNK2A2/MAPK3/NECTIN3/CSNK2B/BAIAP2/CSNK2A1/ACTB/PDCD10/MYL12B/NECTIN1	-0.248958555393934
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	17/1706	99/9376	0.943739860504222	PLCB1/BDKRB1/GNAS/IL1B/PLA2G4C/PRKACA/CALM2/CALM3/ITPR3/PPP1CC/PPP1CA/ADCY8/MAPK9/PRKACB/PLCG1/ADCY6/ASIC1	-0.265394606901155
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/1706	59/9376	0.931507938084924	MAP2K2/MAPK3/CCND1/ILK/TP53/KRAS/BAX/GRB2/PDPK1/ARAF	-0.248888980251251
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	11/1706	65/9376	0.930074848949409	PLCB1/GNAS/CREB1/ORAI1/PRKACA/ITPR3/ADCY8/CREB3L1/PRKACB/ADCY6/ATF6B	-0.266789908345409
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	12/1706	71/9376	0.92888397206215	SHC3/SHC1/MAP2K2/MAPK3/CCND1/SOCS6/KRAS/GALT/MAPK9/PRL/GRB2/SOCS5	-0.283671658065261
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	15/1706	89/9376	0.926274747421526	GABARAP/GNG11/GNG5/PRKACA/GABARAPL2/GNAI2/ADCY8/GABRE/GNG12/GNG10/PRKACB/ADCY6/KCNJ6/GNB2/GNG2	-0.329572540143172
Organismal Systems	Nervous system	hsa04730	Long-term depression	10/1706	60/9376	0.915982805783509	PLCB1/GNAS/GRIA3/MAP2K2/PLA2G4C/MAPK3/ITPR3/GNAI2/KRAS/ARAF	-0.307897759694792
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	13/1706	78/9376	0.915982805783509	CYBA/ITGB1/EEF1A1/IL1A/IL1B/MAPK3/TGFB1/MYD88/IRAK1/EEF1A2/C3/MARCKSL1/TAB2	-0.351397100849867
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/1706	49/9376	0.897289279134866	GNAS/CREB1/PRKACA/GNAI2/CREB3L1/PRKACB/ATF6B/DLG4	-0.339954111920101
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1706	19/9376	0.867773184426482	PDHA1/OGDH/DBT	-0.272085560367602
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	25/1706	149/9376	0.922130341392794	PLCB1/DGKI/CXCL8/SHC3/GNAS/PLPP2/SHC1/RALB/MAP2K2/PLA2G4C/MAPK3/RALA/ADCY8/TSC1/KRAS/GRB2/ARF6/DGKE/DGKZ/PLCG1/ADCY6/DNM1/AGPAT1/TSC2/CYTH2	-0.451864907022136
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	26/1706	155/9376	0.921892372272435	PLCB1/GNAS/CDKN2A/CREB1/ORAI1/MAP2K2/MAPK3/CCND1/AIP/PRKACA/FH/ITPR3/GNAI2/ADCY8/CREB3L1/AHR/DVL1/WDR5/KMT2D/PRKACB/ADCY6/ATF6B/E2F1/DVL3/ASH2L/ARMC5	-0.462431868013239
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	31/1706	184/9376	0.925939140628982	ITGB1/CFL1/RAC2/MYL12A/NRP1/RAC1/EFNA5/MYL5/SLIT3/MAPK3/EPHA5/RYK/ILK/NCK1/PPP3R1/GNAI2/NTNG1/UNC5B/EPHB2/KRAS/SEMA4B/EPHA4/ROBO2/PLCG1/PDPK1/RGS3/MYL12B/PPP3CC/LIMK2/LIMK1/EFNB1	-0.478486975188715
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	19/1706	115/9376	0.908017737907131	PLCB1/GNG11/CREB1/MAPK3/GNG5/PRKACA/ITPR3/GNAI2/ADCY8/CREB3L1/KRAS/GNG12/GNG10/PRKACB/ADCY6/KCNJ14/KCNJ6/GNB2/GNG2	-0.468060005688983
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	13/1706	80/9376	0.893083235638922	IL6/SHC3/VEGFA/SHC1/MAP2K2/MAPK3/RPS6/KRAS/BAX/GRB2/PLCG1/EIF4E/ARAF	-0.452918658987602
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	14/1706	86/9376	0.894680880067614	SHC3/AREG/SHC1/MAP2K2/MAPK3/NCK1/KRAS/MAPK9/GRB2/CRK/PLCG1/MAP2K7/CRKL/ARAF	-0.462728298226561
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1706	20/9376	0.824384525205158	NANS/UAP1L1/CYB5R1	-0.370774743473835
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	11/1706	69/9376	0.876157466401617	RAC2/RAC1/MAP2K2/PLA2G4C/MAPK3/KRAS/MAPK9/GRB2/PLCG1/PDPK1/MAP2K7	-0.486930508920299
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	7/1706	45/9376	0.854917285397942	HLA-C/HLA-A/HLA-B/IL6/IL1A/IL1B/HLA-F	-0.460082065964858
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	17/1706	105/9376	0.889811868475409	IL6/IKBKE/IL1B/STAT2/BCL10/MAPK3/PYCARD/CALM2/NFKB2/CALM3/ITPR3/PPP3R1/KRAS/MAPK9/IRF9/PPP3CC/CHUK	-0.535480484142135
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	26/1706	158/9376	0.904388086722958	CDKN2A/CDC26/SMC3/SKP1/ANAPC11/ZBTB17/CCND1/YWHAB/TP53/CDC16/TGFB1/FZR1/CUL1/ESCO1/MCM3/ANAPC13/ANAPC5/CHEK1/ORC4/TFDP1/E2F1/PRKDC/MAD2L2/YWHAQ/PCNA/ANAPC15	-0.571609805450024
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	32/1706	193/9376	0.911236780883077	PLCB1/RAC2/GNG11/CXCL8/SHC3/CXCL1/RAC1/CXCL6/SHC1/STAT2/CXCL5/MAPK3/GNG5/PRKACA/GNAI2/ADCY8/KRAS/GRB2/CCL2/GNG12/GNG10/PRKACB/CRK/PXN/PLCG1/CXCL3/ADCY6/CRKL/CHUK/GNB2/GNG2/CCL7	-0.587620415735531
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/1706	70/9376	0.863640931167309	RXRB/TRADD/MAPK9/PRKAG1/ADIPOR2/G6PC3/CPT1C/ACSL5/CHUK/PRKAB1/TNFRSF1A	-0.540043809834614
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/1706	52/9376	0.845522589954009	ANGPTL4/NPC2/TSPO/VDAC3/VDAC2/VAPB/PCSK9/VDAC1	-0.526796630577573
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	16/1706	101/9376	0.87063712232888	PLCB1/GNAS/CREB1/MAP2K2/MAPK3/PRKACA/CALM2/CALM3/GNAI2/ADCY8/CREB3L1/KRAS/DVL1/PRKACB/ADCY6/DVL3	-0.616440075914141
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	27/1706	166/9376	0.893910930945352	PLCB1/ATP1B1/SLC25A6/ATP1B3/SLC25A5/ATP2B1/CREB1/MAP2K2/MAPK3/GATA4/VDAC3/CALM2/CALM3/ITPR3/PPP1CC/PPP1CA/PPP3R1/GNAI2/ADCY8/CREB3L1/ATP1A1/VDAC2/ADCY6/ATF6B/VDAC1/PPP3CC/ATP2A2	-0.650387726394211
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1706	28/9376	0.785128119243008	B4GALT2/B4GALT3/FUT4/B3GNT5	-0.537003008317123
Organismal Systems	Digestive system	hsa04976	Bile secretion	14/1706	90/9376	0.854917285397942	ATP1B1/ABCC3/GNAS/ATP1B3/EPHX1/SLC4A2/PRKACA/ADCY8/ATP1A1/PRKACB/HMGCR/ADCY6/SLC9A1/SLC4A4	-0.652228929034043
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	8/1706	54/9376	0.81420693847423	RPA3/RPA2/RPA1/MUS81/POLH/ATRIP/FAAP100/PALB2	-0.645727513443963
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	16/1706	103/9376	0.853731547138028	PLCB1/CALR/IL6/CXCL8/GNAS/IL1B/MAPK3/TGFB1/GNAI2/MYD88/MAPK9/CCL2/IRAK1/C3/CHUK/TNFRSF1A	-0.703941581961825
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/1706	48/9376	0.801484955060571	PLCB1/ATP1B1/ATP1B3/HK2/ATP1A1/HK1/G6PC3	-0.650275281883318
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/1706	29/9376	0.758054735820835	MOB1A/SAV1/MOB1B/NF2	-0.615399973091345
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	17/1706	110/9376	0.849365874453799	GREM1/BAMBI/EMP3/INHBA/ID1/SKP1/SMAD5/MAPK3/TGFB1/SKIL/CUL1/BMP2/ZFYVE9/GREM2/SMAD9/ID2/TFDP1	-0.749464445746461
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1706	23/9376	0.716856108874051	GPT2/NAGS/GOT1	-0.641169886051167
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1706	23/9376	0.716856108874051	CTSA/PRCP/PREP	-0.641169886051167
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/1706	37/9376	0.742688761446089	MIF/FAH/ALDH3B1/IL4I1/GOT1	-0.739582964728604
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/1706	37/9376	0.742688761446089	PLCB1/IL6/IL1B/ICAM1/MYD88	-0.739582964728604
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1706	31/9376	0.709147978671104	ALDH2/ALDH9A1/AKR1A1/ALDH3A2	-0.764963564528202
NA	NA	hsa04981	Folate transport and metabolism	4/1706	31/9376	0.709147978671104	ABCC3/MTHFD1/FPGS/TYMS	-0.764963564528202
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1706	17/9376	0.646576098200124	CA12/CA9	-0.687833183475287
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	37/1706	233/9376	0.872738982334502	ITGA2/COL1A1/COL3A1/FN1/COL1A2/ITGB1/ATP1B1/DSG2/ITGA11/ITGA3/TPM2/ENO1/ACTG1/ATP1B3/CAPZB/DSC2/FHL3/MYL5/FMNL1/TNNT1/LAMA1/INF2/PDLIM4/COL5A2/LBR/TPM4/EMD/PLEC/SGCB/ATP1A1/ACTB/CAPZA1/CAPZA2/THBS2/COL6A1/FMNL3/OBSCN	-0.927697662033279
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1706	45/9376	0.732786244626807	ABCC3/ABCD4/ABCA13/TAP1/ABCB8/ABCD1	-0.847380454408611
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	24/1706	157/9376	0.84013709575048	HIF1A/DUSP4/CALR/RAC1/PANX1/VPS16/CREB1/MAP2K2/MAPK3/SIRPA/CASP3/TGFB1/BSG/SLC16A1/ODC1/PPARD/UQCRFS1/CRK/RAB5B/CPT1C/CRKL/VPS11/ATP2A2/DNMT3A	-0.952649375167647
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	20/1706	133/9376	0.826450651834745	GABARAP/FBXO32/IL6/HOMER3/MAP2K2/CAT/MAPK3/CCND1/GABARAPL2/TGFB1/ATG12/KRAS/MAPK9/GRB2/PRKAG1/PDPK1/G6PC3/CHUK/PRKAB1/ARAF	-0.95064813482453
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	34/1706	217/9376	0.861108259814912	CYP1B1/GSTO1/MGST1/GSTM3/GNAS/VEGFA/IKBKE/EPHX1/CREB1/MAP2K2/RXRB/MAPK3/CCND1/AIP/PRKACA/HSP90B1/MGST3/GNAI2/ADCY8/XIAP/CREB3L1/KRAS/AHR/GRB2/FGF5/PAQR5/PRKACB/ADCY6/MGST2/ATF6B/E2F1/KPNA3/KPNA2/NOTCH2	-0.976247031483402
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	13/1706	90/9376	0.793851765012375	HIF1A/MAP2K2/CSNK2A2/MAPK3/TICAM2/CSNK2B/PPP3R1/MYD88/KRAS/CSNK2A1/PLCG1/PPP3CC/CHUK	-0.926753010494951
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	16/1706	109/9376	0.806737150047861	IL6/SREBF1/CREB1/GYS1/GFPT1/PPP1CC/PPP1CA/CREB3L1/MAPK9/PRKAG1/PDPK1/G6PC3/PRKAB1/TNFRSF1A/MLXIP/PPP1R3E	-0.957126887777951
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/1706	39/9376	0.704602158295007	MAT2A/ATIC/AHCYL1/MTHFD1/TYMS	-0.871793068351226
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	15/1706	103/9376	0.800373325441901	DPP4/COL1A1/COL3A1/COL1A2/ATP1B1/ATP1B3/SLC3A2/PRSS3/PRCP/COL5A2/COL7A1/ATP1A1/COL22A1/COL8A1/COL6A1	-0.960737017043689
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/1706	59/9376	0.74520635046794	GNAS/PRKACA/PTGS1/GNAI2/ADCY8/PRKACB/ADCY6/PNPLA2	-0.925878559257845
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	17/1706	116/9376	0.805433156809637	CYBA/ITGB1/MMP2/RAC2/MYL12A/ACTG1/CD99/RAC1/MYL5/ICAM1/GNAI2/CLDN11/ACTB/PXN/PLCG1/MYL12B/CLDN14	-0.994419892781296
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1706	26/9376	0.634141942465506	FADS2/PLA2G4C/ACOX3	-0.880989966729632
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	27/1706	178/9376	0.833647272679374	PLCB1/BAMBI/RAC2/RAC1/SKP1/CSNK2A2/CCND1/PRKACA/CACYBP/RYK/TP53/RUVBL1/CSNK2B/PPP3R1/CUL1/APCDD1L/FRZB/CCAR2/PPARD/CSNK2A1/DVL1/MAPK9/CHD8/PRKACB/LZTS2/PPP3CC/DVL3	-1.05674619709981
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/1706	73/9376	0.752862580096035	CDKN2A/MAP2K2/MAPK3/CCND1/TP53/KRAS/BAX/FGF5/E2F1/ARAF	-0.999691265446489
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	15/1706	106/9376	0.777721250193546	GSTP1/CREB1/MAP2K2/MAPK3/CCND1/HSP90B1/TP53/CREB3L1/KRAS/GRB2/PDPK1/CHUK/E2F1/MMP3/ARAF	-1.08539665957652
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	23/1706	157/9376	0.805131383427543	ACTG1/AREG/ID1/CCND1/PRKCI/YWHAB/MOB1A/CSNK1D/SAV1/PPP1CC/PPP1CA/TGFB1/BMP2/ACTB/DVL1/ID2/SCRIB/BIRC3/MOB1B/DVL3/DLG4/YWHAQ/NF2	-1.16125418019291
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	32/1706	212/9376	0.829569333539782	PLCB1/PFN1/ITGB1/RAC2/SIPA1L1/GNAS/ACTG1/VEGFA/RAC1/EFNA5/RALB/ID1/PFN2/MAP2K2/MAPK3/PRKCI/CALM2/CALM3/GNAI2/RALA/ADCY8/KRAS/ACTB/FGF5/CRK/PLCG1/PRKD2/ADCY6/RAPGEF6/ADORA2B/CRKL/VEGFC	-1.18372440642509
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	19/1706	133/9376	0.785128119243008	HLA-C/HLA-A/HLA-B/RAC2/SHC3/RAC1/SHC1/MAP2K2/ICAM1/BID/MAPK3/CASP3/PPP3R1/KRAS/GRB2/PLCG1/IFNAR2/PPP3CC/ARAF	-1.17699982643189
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	19/1706	134/9376	0.77926895417403	PLCB1/GNAS/MAP2K2/PLA2G4C/MYL6/MAPK3/PRKACA/MYL6B/CALM2/CALM3/ITPR3/PPP1CC/PPP1CA/ADCY8/PRKACB/ARHGEF1/ADCY6/ADORA2B/ARAF	-1.21369708176763
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	15/1706	109/9376	0.75631607816987	HIF1A/IL6/RUNX1/IL1B/STAT6/RXRB/MAPK3/PPP3R1/TGFB1/AHR/MAPK9/PLCG1/PPP3CC/CHUK/TYK2	-1.20683532174217
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1706	43/9376	0.639057771476867	ACAT2/PLPP2/ACAT1/DGAT2/AGPAT1	-1.11876471330813
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1706	36/9376	0.610655203855673	AKR1B1/RPE/AKR1B10/AKR1A1	-1.10379813602981
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/1706	91/9376	0.724733648532007	RAC2/RAC1/MAP2K2/BCL10/MAPK3/CARD11/PPP3R1/KRAS/GRB2/INPPL1/PPP3CC/CHUK	-1.24440096232302
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/1706	51/9376	0.646576098200124	PLPP2/PAFAH1B3/PLA2G4C/PAFAH1B2/PLD3/SELENOI	-1.19353196478393
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	20/1706	144/9376	0.763319004819591	INHBA/ID1/LIF/MAP2K2/SMAD5/MAPK3/JARID2/SKIL/PCGF3/SETDB1/KRAS/DVL1/REST/GRB2/PCGF2/SMAD9/ID2/PCGF6/DVL3/PCGF1	-1.3498148585717
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	35/1706	238/9376	0.808220122750155	RAC2/GNG11/SHC3/HTR7/VEGFA/RAC1/EFNA5/SHC1/RALB/MAP2K2/PLA2G4C/MAPK3/GNG5/PRKACA/CALM2/TBK1/CALM3/RALBP1/RALA/RGL2/KRAS/MAPK9/BRAP/GRB2/FGF5/ARF6/GNG12/GNG10/PRKACB/PLCG1/RAB5B/CHUK/VEGFC/GNB2/GNG2	-1.41332944688247
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/1706	39/9376	0.563681726636006	HLA-C/HLA-A/HLA-B/HLA-F	-1.28768458198006
Human Diseases	Substance dependence	hsa05034	Alcoholism	27/1706	191/9376	0.776906882392296	GNG11/SHC3/GNAS/PKIA/SHC1/HAT1/CREB1/MAPK3/GNG5/PRKACA/CALM2/CALM3/PPP1CC/PPP1CA/GNAI2/CREB3L1/KRAS/GRB2/GNG12/GNG10/PRKACB/CAMKK1/ATF6B/ADORA2B/GNB2/GNG2/ARAF	-1.4690640987746
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/1706	47/9376	0.584669876032027	PKM/HK2/MAPK3/MAPK9/HK1	-1.34617736452106
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1706	26/9376	0.422761294977004	ABCD4/LRAT	-1.38999674070406
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/1706	65/9376	0.591865812967806	PLCB1/SPP1/MAP2K2/MAPK3/ITPR3/KRAS/KCNJ6	-1.55718050965908
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1706	17/9376	0.323288049100062	ADO	-1.31701600574497
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8/1706	73/9376	0.602290064076828	GSTO1/GSTP1/MGST1/GSTM3/GSTK1/ALDH3B1/MGST3/MGST2	-1.60876952295681
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7/1706	66/9376	0.58289814913496	CYP1B1/AKR1C1/SRD5A3/HSD11B1/AKR1C3/HSD17B7/AKR1C2	-1.60367631077009
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	15/1706	122/9376	0.675725020659966	MAP2K2/BCL10/MAPK3/NCK1/CARD11/PPP3R1/KRAS/MAPK9/GRB2/PLCG1/PDPK1/MAP2K7/PPP2R3C/PPP3CC/CHUK	-1.70022374725003
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	53/1706	362/9376	0.80464787911369	ITGA2/COL1A1/FN1/COL1A2/ITGB1/DDIT4/IL6/SPP1/ITGA11/GNG11/ITGA3/VEGFA/RAC1/EFNA5/AREG/CREB1/MAP2K2/MAPK3/CCND1/LAMA1/GNG5/YWHAB/HSP90B1/GYS1/TP53/RPS6/LAMC2/MTCP1/LAMB2/CREB3L1/TSC1/KRAS/PRL/GRB2/FGF5/GNG12/GNG10/PDPK1/THBS2/G6PC3/ATF6B/IFNAR2/EIF4E/PPP2R3C/CHUK/VEGFC/GNB2/PKN1/COL6A1/GNG2/TSC2/LAMA5/YWHAQ	-1.78768546324524
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	31/1706	226/9376	0.753861955202357	ATP1B1/RAC2/GNAS/GRIA4/POPDC3/ATP1B3/RAC1/ATP2B1/GRIA3/CREB1/ORAI1/MAP2K2/MAPK3/PDE4A/PRKACA/CALM2/CALM3/PPP1CC/PPP1CA/GNAI2/ADCY8/CREB3L1/ATP1A1/MAPK9/PRKACB/GIPR/ACOX3/ADCY6/SLC9A1/ATP2A2/ADCY10	-1.76644405975746
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1706	29/9376	0.379027367910418	CALM2/CALM3	-1.57947518574038
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1706	38/9376	0.433886592213241	ORAI1/TAP1/RFXANK	-1.64909537605258
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/1706	62/9376	0.531860984003328	PSENEN/DTX3L/DVL1/MAML1/DVL3/NOTCH2	-1.74413475202419
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/1706	63/9376	0.523418746162005	TP53/BMP2/BAX/DVL1/DVL3/KIF7	-1.78994587326245
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/1706	100/9376	0.604548651817116	IL6/CXCL8/CXCL1/CXCL6/CXCL5/IL24/CCL2/CXCL3/IL10RB/TNFRSF1A/CCL7	-1.87495202660721
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	10/1706	93/9376	0.590956648892587	STAT6/MAPK3/PPP3R1/MAPK9/MAML1/PLCG1/PPP3CC/CHUK/TYK2/NOTCH2	-1.86958022771991
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1706	41/9376	0.402138792783004	GRIA4/GRIA3/GABRE	-1.80930845046617
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	19/1706	160/9376	0.65263774912075	CDH2/HLA-C/ITGB1/HLA-A/HLA-B/CADM3/CD99/SLITRK4/ICAM1/NECTIN3/NLGN2/HLA-F/NTNG1/CLDN11/CNTNAP1/CLDN14/LRRC4B/CD276/NECTIN1	-2.09001233004292
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1706	54/9376	0.407103469237115	HLA-C/HLA-A/HLA-B/HLA-F	-2.06062378968855
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	16/1706	148/9376	0.594151009156871	SHC3/SHC1/MAP2K2/MAPK3/CCND1/TP53/NFKB2/KRAS/BAX/DVL1/GRB2/FGF5/E2F1/DVL3/ARAF/NOTCH2	-2.34703196712294
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/1706	66/9376	0.416355820810686	IL6/IL1A/IL1B/STAT6/TGFB1	-2.24399949830864
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	16/1706	150/9376	0.586228995701446	SHC3/SHC1/MAP2K2/RXRB/MAPK3/CCND1/TP53/TGFB1/KRAS/BAX/DVL1/GRB2/FGF5/E2F1/DVL3/ARAF	-2.40921982096299
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/1706	100/9376	0.494630715123095	ITGA2/IL6/CD9/IL11/ITGA3/IL1A/IL1B/CD14/CD7	-2.39610553667092
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1706	50/9376	0.329753810082063	IL6/TGFB1/TNFSF13B	-2.24103748109413
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/1706	41/9376	0.268092528522003	PGAM1/GRHPR	-2.21497290193613
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	18/1706	168/9376	0.588846089432256	IL6/IL11/STAT6/STAT2/LIF/CCND1/IL24/SOCS6/PRL/GRB2/IRF9/IL10RB/IFNE/IFNAR2/PIAS4/SOCS5/TYK2/PIAS3	-2.5360270437233
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1706	30/9376	0.183196561156702	PLA2G4C	-2.11321053043562
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	30/1706	254/9376	0.649121673389888	PLCB1/BDKRB1/ASPH/GNAS/SLC25A6/HTR7/VEGFA/SLC25A5/ATP2B1/ORAI1/PRKACA/VDAC3/CALM2/CALM3/ITPR3/PPP3R1/ADCY8/VDAC2/FGF5/PRKACB/TFEB/STIM2/PLCG1/ADORA2B/VDAC1/ORAI3/PPP3CC/VEGFC/PLCD4/ATP2A2	-2.6736578969856
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/1706	88/9376	0.43717361185122	SERPINB2/BDKRB1/PLAUR/CFB/SERPINE2/THBD/C3	-2.50168228665747
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	21/1706	201/9376	0.574198176759812	HMGA2/IL6/NUPR1/RUNX1/CXCL8/GRIA3/CD14/DDIT3/RXRB/ZBTB17/RUNX2/TP53/DUSP6/CDK9/BAX/PML/ID2/PRCC/BIRC3/MMP3/SS18L1	-2.87792835812498
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1706	68/9376	0.323288049100062	ALDH1A3/LRAT/DHRS4L2/RETSAT	-2.64123829229415
Organismal Systems	Sensory system	hsa04742	Taste transduction	6/1706	86/9376	0.38343466288612	PLCB1/PRKACA/ITPR3/ADCY8/PRKACB/ADCY6	-2.70893100294944
NA	NA	hsa04082	Neuroactive ligand signaling	20/1706	199/9376	0.552351440673473	PLCB1/GNG11/GNAS/HTR7/GRIA4/GRIA3/GNG5/PRKACA/GNAI2/ADCY8/GABRE/GNG12/GNG10/PRKACB/ADCY6/ADORA2B/GNB2/GNG2/OGFR/GLRB	-3.01016868285676
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	18/1706	195/9376	0.507313553972405	PLCB1/CYBA/RAC2/SLC25A6/ACTG1/RAC1/SLC25A5/HAT1/MAP2K2/MAPK3/VDAC3/GSDMD/ACTB/VDAC2/PLCG1/CASP4/C3/VDAC1	-3.27884129767197
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	31/1706	298/9376	0.571720811663533	IL33/IL6/GDF15/TNFRSF12A/TNFRSF21/IL11/CXCL8/CXCL1/IL1A/INHBA/CXCL6/TNFSF9/IL1B/LIF/CXCL5/IL24/TNFRSF11B/TGFB1/GDF11/BMP2/PRL/CCL2/RELL2/IL32/CXCL3/IL10RB/IFNE/IFNAR2/TNFRSF1A/CCL7/TNFSF13B	-3.54337799187137
NA	NA	hsa04519	Cadherin signaling	45/1706	404/9376	0.612166726637494	CDH2/ARPC1B/DSG2/BRK1/RAC2/ARPC2/SCN1B/PCDH7/ACTG1/KRT19/RAC1/ACTR3C/ARPC3/PCDH20/DSC2/MYO1C/ATN1/MAP2K2/DSC3/PSENEN/MAPK3/YWHAB/RYK/ARPC1A/MOB1A/ARPC4/LHFPL2/SAV1/PPP1CC/PPP1CA/KRT10/KRT8/KRAS/MYO1B/CIB2/ACTB/DVL1/MAPK9/GABRE/CHUK/ACTR3/MOB1B/DVL3/YWHAQ/NF2	-3.75810219229035
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/1706	99/9376	0.277570547207124	CFB/KRT19/ICAM1/KRT10/C3	-3.40789913349164
NA	NA	hsa04081	Hormone signaling	19/1706	219/9376	0.476812967394155	PLCB1/GNG11/GNAS/THRA/SMAD5/GNG5/PRKACA/GNAI2/ADCY8/PRL/SMAD9/GNG12/ADIPOR2/GNG10/PRKACB/GIPR/ADCY6/GNB2/GNG2	-3.69470604598305
NA	NA	hsa04382	Cornified envelope formation	17/1706	217/9376	0.430554129907456	S100A6/S100A11/DSG2/S100A13/KRT19/S100A16/COL7A1/LAMC2/KRT10/KRT8/KDSR/PLEC/CLDN11/GBA2/PPP2R3C/LAMA5/CLDN14	-4.00254068044296
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	26/1706	323/9376	0.442394172452717	HMGA2/CYP1B1/DDIT4/HMOX1/VEGFA/MMP16/EFNA5/CDKN2A/SHC1/MAP2K2/MAPK3/CCND1/TP53/CASP3/KRAS/RDX/GRB2/STMN1/CRK/PLCG1/SOX4/CRKL/E2F1/BCL2L2/DNMT3A/NOTCH2	-4.80960903289944
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/1706	143/9376	0.153731379991638	RO60/SSB/SNRPD3/C3	-4.80930486265146
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	17/1706	370/9376	0.25251417889167	NMB/BDKRB1/TSPO/NR3C1/HTR7/GRIA4/GRIA3/PRSS3/THRA/PRL/GABRE/PGRMC2/GIPR/ADORA2B/C3/OGFR/GLRB	-6.91855375149783
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/1706	449/9376	0.0489612190173813	PRKACA/CALM2/CALM3/PRKACB	-9.7397116494724