category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	80/217	238/9376	14.5234868140805	RPL13/RPS23/RPS27A/RPS18/RPL10/RPL28/CFD/RPL41/RPS11/RPL26/RPS15A/RPL39/RPL7A/CXCL8/RPL32/RPL13A/RPS14/RPL15/RPS9/RPS12/RPL27A/RPL12/UBA52/RPS7/RPLP1/RPS4X/RPL30/RPL3/RPL18A/FAU/RPL29/RPS16/RPL21/RPL35/RPS8/RPL18/RPL11/RPL24/RPL9/RPS2/RPL17/RPS15/RPS25/F13A1/RPL10A/RPL23A/RPS19/RPL34/RPL19/RPL36/RPLP0/RPS3A/CYBB/RPL37A/RPL23/C1QA/RPLP2/RPS26/CCL2/RPS24/RPL14/RPS5/RPS17/RPL37/RPL36A/RPL38/RPS13/RPL7/RPL31/C1QC/RPL22/RPL6/RPL5/RPS6/RPL35A/RPS20/RPL8/RPS27/FCGR2A/RPL27	32.5269288117268
Genetic Information Processing	Translation	hsa03010	Ribosome	74/217	222/9376	14.4024577572965	RPL13/RPS23/RPS27A/RPS18/RPL10/RPL28/RPL41/RPS11/RPL26/RPS15A/RPL39/RPL7A/RPL32/RPL13A/RPS14/RPL15/RPS9/RPS12/RPL27A/RPL12/UBA52/RPS7/RPLP1/RPS4X/RPL30/RPL3/RPL18A/FAU/RPL29/RPS16/RPL21/RPL35/RPS8/RPL18/RPL11/RPL24/RPL9/RPS2/RPL17/RPS15/RPS25/RACK1/RPL10A/RPL23A/RPS19/RPL34/RPL19/RPL36/RPLP0/RPS3A/RPL37A/RPL23/RPLP2/RPS26/RPS24/RPL14/RPS5/RPS17/RPL37/RPL36A/RPL38/RPS13/RPL7/RPL31/RPL22/RPL6/RPL5/RPS6/RPL35A/RPS20/RPL8/RPS27/RPL27/MRPL51	31.1061997029365
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	23/217	138/9376	7.20122887864823	NDUFA11/NDUFA4/MT-CO3/COX4I1/MT-ND1/NDUFS8/ATP5MC3/ATP5F1E/MT-CO2/MT-CYB/UQCR10/UQCRQ/MT-ATP6/MT-CO1/ATP5PF/COX7C/ATP5ME/NDUFC2/UQCRH/NDUFB2/COX6C/ATP5MF/NDUFA1	11.295872993741
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	27/217	205/9376	5.69072721141958	CYBA/CYBB/SLC25A6/CD36/COL1A1/NDUFA11/NDUFA4/MT-CO3/COX4I1/COL3A1/MT-ND1/NDUFS8/ATP5MC3/ATP5F1E/MT-CO2/MT-CYB/UQCR10/UQCRQ/MT-ATP6/MT-CO1/ATP5PF/COX7C/NDUFC2/UQCRH/NDUFB2/COX6C/NDUFA1	10.4520201127766
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	28/217	227/9376	5.32954383970442	CYBA/MGST1/SLC25A6/NDUFA11/NDUFA4/CYP1B1/MT-CO3/COX4I1/MT-ND1/NDUFS8/ATP5MC3/ATP5F1E/MT-CO2/MT-CYB/UQCR10/UQCRQ/MT-ATP6/HGF/MT-CO1/ATP5PF/COX7C/NDUFC2/UQCRH/NDUFB2/GSTO1/COX6C/NDUFA1/MGST3	10.1638847520517
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	28/217	268/9376	4.51420317766009	RPS27A/UBA52/SLC25A6/NDUFA11/NDUFA4/MT-CO3/UBB/COX4I1/MT-ND1/NDUFS8/ATP5MC3/ATP5F1E/MT-CO2/MT-CYB/UQCR10/UQCRQ/MT-ATP6/CALM1/MT-CO1/CALM3/ATP5PF/COX7C/NDUFC2/PSMA7/UQCRH/NDUFB2/COX6C/NDUFA1	8.98409278984582
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	25/217	235/9376	4.5965290714776	ACTG1/NDUFA11/NDUFA4/MT-CO3/COX4I1/MT-ND1/NDUFS8/ATP5MC3/ATP5F1E/MT-CO2/MT-CYB/UQCR10/UQCRQ/MT-ATP6/RPS6/MT-CO1/ATP5PF/COX7C/ATP5ME/NDUFC2/UQCRH/NDUFB2/COX6C/ATP5MF/NDUFA1	8.59433201791856
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	27/217	275/9376	4.2421784666946	CYBA/CYBB/C1QA/SLC25A6/NDUFA11/NDUFA4/MT-CO3/COX4I1/MT-ND1/NDUFS8/ATP5MC3/C1QC/ATP5F1E/MT-CO2/MT-CYB/UQCR10/UQCRQ/MT-ATP6/MT-CO1/ATP5PF/COX7C/NDUFC2/PSMA7/UQCRH/NDUFB2/COX6C/NDUFA1	8.39943710390252
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	29/217	388/9376	3.22941707444534	APOE/DKK1/CYBB/SLC25A6/NDUFA11/NDUFA4/MT-CO3/COX4I1/MT-ND1/NDUFS8/ATP5MC3/ATP5F1E/MT-CO2/MT-CYB/UQCR10/UQCRQ/MT-ATP6/CALM1/MT-CO1/CALM3/ATP5PF/COX7C/NDUFC2/PSMA7/UQCRH/NDUFB2/COX6C/NDUFA1/WNT2	6.90346503372062
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	17/217	157/9376	4.67850538612815	CXCL8/NDUFA11/NDUFA4/MT-CO3/COX4I1/NDUFS8/MT-CO2/MT-CYB/UQCR10/UQCRQ/MT-CO1/COX7C/NDUFC2/UQCRH/NDUFB2/COX6C/NDUFA1	7.15436001646514
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	31/217	480/9376	2.79047619047619	RPS27A/UBA52/DKK1/CYBB/SLC25A6/NDUFA11/NDUFA4/MT-CO3/UBB/COX4I1/MT-ND1/NDUFS8/ATP5MC3/ATP5F1E/MT-CO2/MT-CYB/UQCR10/UQCRQ/MT-ATP6/CALM1/MT-CO1/CALM3/ATP5PF/COX7C/NDUFC2/PSMA7/UQCRH/NDUFB2/COX6C/NDUFA1/WNT2	6.19845221328352
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	23/217	308/9376	3.22652462744629	SLC25A6/NDUFA11/NDUFA4/MT-CO3/COX4I1/MT-ND1/NDUFS8/ATP5MC3/ATP5F1E/MT-CO2/MT-CYB/UQCR10/UQCRQ/MT-ATP6/MT-CO1/ATP5PF/COX7C/NDUFC2/PSMA7/UQCRH/NDUFB2/COX6C/NDUFA1	6.11559309080412
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	12/217	87/9376	5.9596376926744	MT-CO3/COX4I1/MT-CO2/MT-CYB/UQCR10/UQCRQ/SLC8A1/MT-CO1/COX7C/TPM2/UQCRH/COX6C	7.15346690751632
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	24/217	368/9376	2.81787216990583	PFN1/ACTG1/NDUFA11/NDUFA4/MT-CO3/COX4I1/MT-ND1/NDUFS8/ATP5MC3/ATP5F1E/MT-CO2/MT-CYB/UQCR10/UQCRQ/MT-ATP6/MT-CO1/ATP5PF/COX7C/NDUFC2/PSMA7/UQCRH/NDUFB2/COX6C/NDUFA1	5.47601384146497
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/217	78/9376	4.43152546378353	CXCL8/CD14/CFL1/C1QA/C1QC/CALM1/CALM3/ITGB2	4.68415472401976
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	11/217	155/9376	3.06632971606957	CD14/CYBA/FCGR3A/HLA-DRA/CYBB/CD36/ACTG1/SEC61B/MSR1/ITGB2/FCGR2A	3.99271154043085
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/217	50/9376	5.18488479262673	CXCL8/CCL2/CD36/HBB/HGF/ITGB2	4.56680301233951
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/217	95/9376	3.63851564394858	CXCL8/CXCL1/CCL3/HLA-DRA/CCL2/CD86/ITGB2/CTSK	3.97846521655656
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/217	142/9376	3.04277276562601	CYBA/MGST1/CCL2/MEF2C/ACTG1/CALM1/CALM3/GSTO1/BMP4/MGST3	3.77538087848001
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/217	99/9376	3.05506679700228	CFD/FCGR3A/HLA-DRA/C1QA/C1QC/ITGB2/FCGR2A	3.16396184196994
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/217	78/9376	3.32364409783765	CYBA/FCGR3A/HLA-DRA/CYBB/ITGB2/FCGR2A	3.17185712089283
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/217	56/9376	3.85780118499012	CXCL8/CD14/CXCL1/ITGB2/EEF1G	3.30148664568114
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/217	109/9376	2.77478543947914	CXCL8/CD14/CCL4/SPP1/CCL3/CD86/CTSK	2.86867269808825
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/217	61/9376	3.54158797310569	MT1E/FTL/FTH1/SLC8A1/ATOX1	3.06527970815309
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/217	42/9376	4.11498793065613	FTL/GPX4/CYBB/FTH1	3.11414328343812
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/217	88/9376	2.94595726853791	CFD/F13A1/C1QA/C1QC/CD59/ITGB2	2.82296184085236
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/217	70/9376	3.0862409479921	MGST1/CYP1B1/HSD11B1/GSTO1/MGST3	2.69664288487705
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	9/217	181/9376	2.14843292512157	CD14/FCGR3A/FCER1G/HLA-DRA/CD74/CALM1/CALM3/ITGB2/FCGR2A	2.40137802073677
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/217	100/9376	2.59244239631336	CXCL14/CXCL8/CXCL1/CCL4/CCL3/CCL2	2.46419366710327
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	10/217	216/9376	2.00034135518007	CXCL8/CD14/CYBA/CXCL1/CCL3/CYBB/CCL2/CD36/CALM1/CALM3	2.28938502491287
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/217	103/9376	2.51693436535278	SLC16A10/COL1A1/COL3A1/SLC8A1/COL14A1/COL6A2	2.38268564449526
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	6/217	103/9376	2.51693436535278	CXCL8/CD14/CXCL1/COL1A1/COL3A1/ITGB2	2.38268564449526
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/217	79/9376	2.73464387796768	MGST1/CYP1B1/HSD11B1/GSTO1/MGST3	2.38310914640663
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/217	59/9376	2.92931344216199	GPX4/MGST1/GSTO1/MGST3	2.2881380537987
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/217	149/9376	2.02987659666595	NDUFA11/NDUFA4/MT-ND1/NDUFS8/NDUFC2/NDUFB2/NDUFA1	1.95047118490796
NA	NA	hsa04518	Integrin signaling	7/217	154/9376	1.96397151235861	SPP1/COL1A1/ACTG1/HGF/ITGB2/PDGFC/COL6A2	1.85653643486263
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/217	70/9376	2.46899275839368	HLA-DRA/CD86/ACTG1/ITGB2	1.89879739138992
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	8/217	195/9376	1.77261018551341	CYBA/FCGR3A/CYBB/SLC25A6/ACTG1/HMGB1/ITGB2/FCGR2A	1.6781246502287
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/217	101/9376	2.13897887484601	CXCL8/CYBB/CCL2/COL1A1/COL3A1	1.77137647412964
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	8/217	196/9376	1.76356625599549	RPS27A/CXCL8/UBA52/CXCL1/CD86/UBB/CALM1/CALM3	1.66281869348733
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/217	46/9376	2.81787216990583	FTL/FTH1/BLVRB	1.90236089763052
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/217	103/9376	2.09744530446065	CXCL8/CCL3/C1QA/CCL2/C1QC	1.72378398978983
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/217	105/9376	2.05749396532807	CXCL8/CD14/CXCL1/CCL4/GADD45A	1.67726132261441
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/217	170/9376	1.77912713472486	MGST1/ACTG1/GADD45A/HGF/GSTO1/MGST3/WNT2	1.57793380656758
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/217	140/9376	1.85174456879526	SPP1/MEF2C/SLC8A1/RPS6/CALM1/CALM3	1.56287017812638
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/217	143/9376	1.81289678063872	FCGR3A/HLA-DRA/C1QA/CD86/C1QC/FCGR2A	1.50772966632534
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/217	52/9376	2.49273307337823	APOE/APOC1/CD36	1.66139986283155
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/217	82/9376	2.10767674497021	MGST1/NME2/GSTO1/MGST3	1.55063686880182
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	5/217	116/9376	1.86238677896075	CYBA/CYBB/ACTG1/CD99/ITGB2	1.43852385016538
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/217	29/9376	2.9798188463372	CALM1/CALM3	1.64353821763697
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/217	89/9376	1.94190441671413	SPP1/CD36/COL1A1/COL6A2	1.37421786312324
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/217	31/9376	2.78757246915415	SEC61B/SRP14	1.53442733648036
Organismal Systems	Immune system	hsa04611	Platelet activation	5/217	126/9376	1.71457830444006	FCER1G/COL1A1/ACTG1/COL3A1/FCGR2A	1.24295586546188
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/217	93/9376	1.85838164610277	CST3/LYZ/CALM1/CALM3	1.28046938014413
Human Diseases	Immune disease	hsa05310	Asthma	2/217	32/9376	2.70046082949309	FCER1G/HLA-DRA	1.48308718471906
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	8/217	233/9376	1.48351496212496	COL1A1/ACTG1/COL3A1/DCN/VIM/FMNL1/TPM2/COL6A2	1.15036323620342
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/217	94/9376	1.83861162859104	CXCL8/CXCL1/S100A9/CCL2	1.25775340179506
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/217	63/9376	2.05749396532807	GADD45A/BMP4/WNT2	1.29626813886145
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/217	98/9376	1.76356625599549	FCGR3A/PTPRC/CFL1/FCGR2A	1.16956417495852
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	7/217	204/9376	1.48260594560405	LUM/COL1A1/ACTG1/DCN/RPS6/HGF/WNT2	1.07267264207397
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/217	100/9376	1.72829493087558	CD14/HLA-DRA/CD36/CD59	1.12698566717502
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	8/217	248/9376	1.39378623457708	CXCL8/CD14/DYNLL1/S100A10/PTPRC/PFN1/ACTG1/DYNLRB1	0.967364244240449
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	7/217	212/9376	1.42665855143031	PFN1/ACTG1/HGF/CALM1/CALM3/ITGB2/PDGFC	0.967157759155165
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/217	105/9376	1.64599517226245	RPS27A/UBA52/TOMM7/UBB	1.02459470460931
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/217	39/9376	2.21576273189176	HLA-DRA/CD86	1.17103243996093
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/217	142/9376	1.52138638281301	CYBA/FCGR3A/TYROBP/FCGR2A/CTSK	0.963608000407648
NA	NA	hsa04382	Cornified envelope formation	7/217	217/9376	1.39378623457708	SLC27A4/S100A6/S100A10/S100A4/S100A9/S100A16/S100A11	0.903353733160706
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/217	73/9376	1.77564547692696	MGST1/GSTO1/MGST3	1.02401108868915
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/217	73/9376	1.77564547692696	GADD45A/HGF/PDGFC	1.02401108868915
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/217	144/9376	1.50025601638505	CXCL8/CD14/CXCL1/C1QA/C1QC	0.931144632562223
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/217	110/9376	1.57117720988689	BMP5/EMP3/DCN/BMP4	0.927497058425759
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/217	75/9376	1.72829493087558	MGST1/GSTO1/MGST3	0.974685650354547
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/217	76/9376	1.7055542081009	SLC27A4/CD36/DBI	0.950576741622637
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/217	76/9376	1.7055542081009	ACTG1/CALM1/CALM3	0.950576741622637
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/217	76/9376	1.7055542081009	GADD45A/CALM1/CALM3	0.950576741622637
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/217	43/9376	2.00964526845997	SLC27A4/CD36	1.02137185176335
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/217	44/9376	1.96397151235861	HLA-DRA/CD86	0.98649445499035
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/217	45/9376	1.92032770097286	HLA-DRA/CD86	0.952524449164806
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/217	80/9376	1.62027649769585	RPS6/HGF/PDGFC	0.857578210045766
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/217	154/9376	1.40283679454186	MYL6/MEF2C/ACTG1/CALM1/CALM3	0.775833286338879
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/217	46/9376	1.87858144660389	PSMB10/PSMA7	0.919415026574432
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	6/217	193/9376	1.3432344022349	CXCL14/CXCL8/CXCL1/CCL4/CCL3/CCL2	0.741598168312869
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/217	82/9376	1.58075755872766	HLA-DRA/LGMN/CD74	0.813002607924811
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/217	157/9376	1.37603099592004	CXCL8/SLC25A6/GADD45A/CALM1/CALM3	0.731346250655784
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/217	157/9376	1.37603099592004	BMP5/ACTG1/ITGB2/BMP4/WNT2	0.731346250655784
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	5/217	160/9376	1.35023041474654	PTPRC/HLA-DRA/CD86/CD99/ITGB2	0.687755531980944
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/217	16/9376	2.70046082949309	MIF	1.04780429638718
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	6/217	201/9376	1.28977233647431	CXCL8/CD14/CD86/MEF2C/GADD45A/NR4A3	0.639209749557915
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/217	50/9376	1.72829493087558	HLA-DRA/CD86	0.794760106671074
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	6/217	203/9376	1.2770652198588	SPP1/COL1A1/ACTG1/HGF/PDGFC/COL6A2	0.614279199731013
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/217	51/9376	1.69440679497605	ENPP2/PLA2G7	0.765360606865154
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/217	51/9376	1.69440679497605	ACTG1/SEC61B	0.765360606865154
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	5/217	166/9376	1.3014269057798	SLC25A6/MEF2C/SLC8A1/CALM1/CALM3	0.603111653292338
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/217	168/9376	1.28593372833004	FTL/CYBB/SLC25A6/FTH1/HMGB1	0.575610686584445
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/217	54/9376	1.60027308414405	HLA-DRA/CD86	0.680898968931781
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	7/217	253/9376	1.19546092056611	RPS27A/CXCL8/CD14/UBA52/PFN1/ACTG1/UBB	0.485112916963228
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/217	133/9376	1.29946987283878	FCGR3A/FCER1G/TYROBP/ITGB2	0.535382236714688
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	5/217	173/9376	1.24876801363842	CXCL8/HLA-DRA/CCL2/SLC25A6/ACTG1	0.508328377106335
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	8/217	298/9376	1.15992948380911	CXCL14/CXCL8/CXCL1/CCL4/BMP5/CCL3/CCL2/BMP4	0.431850129295341
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/217	21/9376	2.05749396532807	ENPP1	0.746718867340673
NA	NA	hsa04517	IgSF CAM signaling	8/217	299/9376	1.15605012098701	MYL6/DYNLL1/ROBO2/CD86/ACTG1/SLIT2/ITGB2/MTSS1	0.422104528801612
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	4/217	137/9376	1.26152914662451	ACTG1/CTSC/GADD45A/CTSK	0.474634575976705
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	4/217	138/9376	1.25238763106926	CXCL8/CCL2/ACTG1/FCGR2A	0.459737687729235
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/217	59/9376	1.464656721081	ENPP1/NME2	0.551076202665823
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/217	99/9376	1.30931434157241	ACTG1/SLC8A1/TPM2	0.476217500733658
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/217	22/9376	1.96397151235861	HNMT	0.696736131566795
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/217	101/9376	1.28338732490761	CALM1/CALM3/WNT2	0.440733056155877
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4/217	142/9376	1.21710910625041	RPS27A/UBA52/UBB/ELOB	0.401253424793176
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	6/217	227/9376	1.14204510850809	CXCL8/CCL4/CCL3/CCL2/CALM1/CALM3	0.333460097858131
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/217	63/9376	1.37166264355204	GPX4/PTGDS	0.455581269527219
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	5/217	187/9376	1.15527736021095	CXCL8/CYBA/CXCL1/CYBB/CCL2	0.330130988547151
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/217	105/9376	1.23449637919684	FCER1G/CALM1/CALM3	0.371928086604224
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/217	105/9376	1.23449637919684	ACTG1/SLC8A1/TPM2	0.371928086604224
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	6/217	232/9376	1.11743206737645	TMSB4X/PFN1/CFL1/ACTG1/ITGB2/PDGFC	0.278775155036816
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/217	66/9376	1.30931434157241	CYP1B1/HSD11B1	0.388140230763342
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/217	67/9376	1.28977233647431	CALM1/CALM3	0.366382131054623
Cellular Processes	Cell motility	hsa04814	Motor proteins	5/217	194/9376	1.11359209463632	MYL6/DYNLL1/ACTG1/TPM2/DYNLRB1	0.246077442428664
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/217	110/9376	1.17838290741517	CYBB/ELOB/RPS6	0.289664256621452
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/217	69/9376	1.25238763106926	CALM1/CALM3	0.323876346352938
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/217	69/9376	1.25238763106926	CALM1/CALM3	0.323876346352938
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	4/217	154/9376	1.12226943563349	SLC8A1/CALM1/CALM3/TPM2	0.235481712077006
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/217	70/9376	1.23449637919684	ELOB/HGF	0.303106404415653
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/217	71/9376	1.21710910625041	CXCL8/CXCL1	0.282644475182609
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/217	30/9376	1.44024577572965	FOLR2	0.371735820802104
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/217	73/9376	1.18376365128464	GADD45A/HGF	0.242605703521942
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/217	31/9376	1.39378623457708	PRPS2	0.338020624892846
NA	NA	hsa04981	Folate transport and metabolism	1/217	31/9376	1.39378623457708	FOLR2	0.338020624892846
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	6/217	250/9376	1.03697695852535	CTSC/LAPTM5/LGMN/BLOC1S1/LAMTOR1/CTSK	0.0912120956271578
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/217	254/9376	1.0206466127218	SLC25A6/SLC8A1/HGF/CALM1/CALM3/PDGFC	0.051346649680797
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/217	122/9376	1.06247639193171	SLC16A10/ACTG1/BMP4	0.106911047336955
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	4/217	169/9376	1.02265972241158	RPS27A/UBA52/UBB/HMGB1	0.045754134200619
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/217	36/9376	1.20020481310804	ENPP1	0.18524385147286
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/217	128/9376	1.01267281105991	ENPP1/NME2/PRPS2	0.0222200744571326
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/217	37/9376	1.1677668451862	MIF	0.157379545858046
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/217	37/9376	1.1677668451862	HBB	0.157379545858046
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/217	37/9376	1.1677668451862	GADD45A	0.157379545858046
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/217	85/9376	1.01664407698563	ENPP1/NME2	0.0237262676002345
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/217	38/9376	1.13703613873393	ENPP1	0.130284110476939
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/217	38/9376	1.13703613873393	PTPRC	0.130284110476939
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/217	86/9376	1.00482263422999	ACTG1/SLC8A1	0.00691539781834115
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/217	134/9376	0.967329252355733	MYL6/CALM1/CALM3	-0.0586300096656032
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/217	41/9376	1.05383837248511	CXCL8	0.0531763060958313
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/217	138/9376	0.939290723301943	RPS6/CALM1/CALM3	-0.110585223113489
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/217	42/9376	1.02874698266403	CYP1B1	0.0287391877513486
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/217	93/9376	0.929190823051385	CALM1/CALM3	-0.105627821060207
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/217	44/9376	0.981985756179305	HMGB1	-0.0184351419228965
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/217	44/9376	0.981985756179305	DYNLL1	-0.0184351419228965
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/217	97/9376	0.89087367570906	CALM1/CALM3	-0.166286228184937
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/217	98/9376	0.881783127997743	CALM1/CALM3	-0.181074290913027
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/217	98/9376	0.881783127997743	CALM1/CALM3	-0.181074290913027
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/217	99/9376	0.872876227714937	CALM1/CALM3	-0.195718584575413
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/217	149/9376	0.869947112856833	CXCL8/FCER1G/PDGFC	-0.246305634779963
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/217	150/9376	0.864147465437788	GADD45A/HGF/WNT2	-0.258165452783094
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	6/217	300/9376	0.864147465437788	CD14/MEF2C/GADD45A/HGF/STMN1/PDGFC	-0.368105752801611
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/217	52/9376	0.830911024459412	CYP1B1	-0.18819466506071
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	2/217	106/9376	0.815233457960177	FOLR2/PDGFC	-0.294461060668896
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	3/217	157/9376	0.825618597552027	C1QA/CD36/C1QC	-0.339156043645775
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/217	53/9376	0.815233457960177	SLC8A1	-0.207622730968129
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	3/217	158/9376	0.820393163390305	RPS6/LAMTOR1/WNT2	-0.350448762673318
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/217	107/9376	0.807614453680176	CALM1/CALM3	-0.308062875111722
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/217	108/9376	0.800136542072026	SAP18/RAN	-0.321546463846701
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/217	109/9376	0.792795839851182	SLC27A4/CD36	-0.334914240294683
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	4/217	214/9376	0.807614453680176	CFL1/ELOB/CALM1/CALM3	-0.438203315848347
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	4/217	217/9376	0.796449276901187	MGST1/CYP1B1/GSTO1/MGST3	-0.466949551439647
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/217	115/9376	0.751432578641555	MEF2C/NACA	-0.412815181811858
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/217	59/9376	0.732328360540498	GADD45A	-0.317454722900617
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/217	119/9376	0.726174340704023	CXCL1/CCL2	-0.462704759139963
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	4/217	224/9376	0.771560236998025	HLA-DRA/SLC25A6/RAN/ITGB2	-0.532634361029975
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/217	120/9376	0.720122887864823	CALM1/CALM3	-0.474938974023884
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/217	174/9376	0.7449547115843	SEC61B/SSR4/SSR3	-0.522687712010024
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/217	65/9376	0.664728819567529	SPP1	-0.417490131414711
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/217	178/9376	0.728214156267799	SERPINF1/DKK1/WNT2	-0.563484022784788
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/217	66/9376	0.654657170786203	HLA-DRA	-0.433350244098305
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	3/217	180/9376	0.720122887864823	HLA-DRA/CCL2/CD74	-0.583573592080286
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/217	68/9376	0.635402548116021	ALDH1A1	-0.464441879373081
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/217	68/9376	0.635402548116021	CD14	-0.464441879373081
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/217	69/9376	0.626193815534629	FCER1G	-0.479686665926805
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/217	184/9376	0.704468042476458	ROBO2/CFL1/SLIT2	-0.623160374625496
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	4/217	238/9376	0.726174340704023	HGF/CALM1/CALM3/PDGFC	-0.658610301410642
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/217	70/9376	0.61724818959842	CD36	-0.494739089071479
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/217	130/9376	0.664728819567529	COL1A1/COL3A1	-0.592491918131379
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/217	72/9376	0.600102406554019	CXCL8	-0.524290107739063
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/217	133/9376	0.64973493641939	CALM1/CALM3	-0.626192182222467
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/217	73/9376	0.591881825642321	RAN	-0.538799681645261
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/217	75/9376	0.576098310291859	PRPS2	-0.567312604555473
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/217	75/9376	0.576098310291859	GADD45A	-0.567312604555473
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/217	138/9376	0.626193815534629	CALM1/CALM3	-0.680908133956213
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/217	77/9376	0.561134717816746	GADD45A	-0.595182208153916
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/217	77/9376	0.561134717816746	GADD45A	-0.595182208153916
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	2/217	139/9376	0.621688824055963	CALM1/CALM3	-0.691643938531788
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/217	78/9376	0.553940682972941	ACTG1	-0.608886886924507
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	3/217	200/9376	0.648110599078341	CXCL8/ACTG1/FCGR2A	-0.774258455478179
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	6/217	362/9376	0.716144308373857	SPP1/COL1A1/RPS6/HGF/PDGFC/COL6A2	-0.847782779492172
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/217	144/9376	0.600102406554019	BMP4/WNT2	-0.74434386697144
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/217	144/9376	0.600102406554019	SLC25A6/PSMA7	-0.74434386697144
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/217	83/9376	0.520570762311921	PRDX5	-0.675269398293961
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/217	83/9376	0.520570762311921	CCL4	-0.675269398293961
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	3/217	205/9376	0.632303023491064	HLA-DRA/GADD45A/VIM	-0.819313513802791
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/217	148/9376	0.5838834225931	GADD45A/WNT2	-0.785386728213687
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/217	87/9376	0.496636474389533	GADD45A	-0.726019630067686
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/217	89/9376	0.485476104178533	PDGFC	-0.750679066893281
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	1/217	93/9376	0.464595411525693	ACTG1	-0.798676421662376
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/217	93/9376	0.464595411525693	HLA-DRA	-0.798676421662376
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	1/217	93/9376	0.464595411525693	GADD45A	-0.798676421662376
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/217	99/9376	0.436438113857469	PDGFC	-0.867654669884485
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	2/217	170/9376	0.508322038492816	MYL6/ACTG1	-0.995774942019442
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/217	103/9376	0.41948906089213	SAP18	-0.911822629031882
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/217	109/9376	0.396397919925591	HLA-DRA	-0.975631627971269
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	1/217	112/9376	0.385780118499013	HLA-DRA	-1.00652619891502
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/217	116/9376	0.37247735579215	PRPS2	-1.04675339677595
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/217	117/9376	0.369293788648627	ACTG1	-1.05664590065094
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/217	191/9376	0.452433227977899	CALM1/CALM3	-1.17680814311363
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/217	122/9376	0.354158797310569	CD36	-1.10517840832361
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/217	122/9376	0.354158797310569	PTPRC	-1.10517840832361
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/217	125/9376	0.345658986175115	FCER1G	-1.13359072583504
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	4/217	333/9376	0.519007486749422	SPP1/COL1A1/COL6A2/WNT2	-1.37561101112633
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	1/217	133/9376	0.324867468209695	GADD45A	-1.20697939169105
Human Diseases	Infectious disease: viral	hsa05162	Measles	1/217	136/9376	0.31770127405801	RACK1	-1.2336714222646
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	2/217	226/9376	0.382366135149464	CALM1/CALM3	-1.44665925071608
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/217	154/9376	0.280567358908373	NME2	-1.38557301070861
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/217	155/9376	0.278757246915415	WNT2	-1.39363734707863
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/217	158/9376	0.273464387796768	GADD45A	-1.41761589447748
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/217	163/9376	0.265075909643493	CXCL8	-1.45689155456419
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	2/217	250/9376	0.345658986175115	DAB2/FOLR2	-1.61408124156174
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/217	323/9376	0.401306872494329	CYP1B1/VIM/STMN1	-1.6853913064939
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/217	183/9376	0.236105864873713	RAN	-1.60628116205021
NA	NA	hsa04081	Hormone signaling	1/217	219/9376	0.197293941880774	SLC16A10	-1.85009260232191
NA	NA	hsa04519	Cadherin signaling	3/217	404/9376	0.320846831226901	ACTG1/VIM/WNT2	-2.14785647343793
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/217	449/9376	0.288690690012624	SLC8A1/CALM1/CALM3	-2.37749915764434
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/217	370/9376	0.11677668451862	SPX	-2.66806798386627