ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 73/276 175/18639 0.417142857142857 28.1707453416149 7.74242173785937e-89 3.74733212112394e-86 GO:0019843 rRNA binding 15/276 65/18639 0.230769230769231 15.5844481605351 2.63720685521589e-14 6.38204058962246e-12 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 13/276 68/18639 0.191176470588235 12.9106457800512 1.88332975702743e-11 3.03843867467092e-09 GO:0015078 proton transmembrane transporter activity 19/276 185/18639 0.102702702702703 6.93578143360752 3.89780583651433e-11 4.39437648281749e-09 GO:1990948 ubiquitin ligase inhibitor activity 7/276 11/18639 0.636363636363636 42.9752964426877 4.53964512687757e-11 4.39437648281749e-09 GO:0009055 electron transfer activity 15/276 116/18639 0.129310344827586 8.73266491754123 1.78379300429624e-10 1.43892635679897e-08 GO:0055105 ubiquitin-protein transferase inhibitor activity 7/276 15/18639 0.466666666666667 31.5152173913044 8.41376511725804e-10 5.81751759536127e-08 GO:0022853 active monoatomic ion transmembrane transporter activity 13/276 118/18639 0.110169491525424 7.44003316138541 2.16155707732293e-08 1.30774203178037e-06 GO:0048027 mRNA 5'-UTR binding 7/276 24/18639 0.291666666666667 19.6970108695652 4.03693345671937e-08 2.1709731033913e-06 GO:0016209 antioxidant activity 10/276 86/18639 0.116279069767442 7.85262891809909 5.66522129633978e-07 2.74196710742845e-05 GO:0055106 ubiquitin-protein transferase regulator activity 7/276 36/18639 0.194444444444444 13.1313405797101 8.36366151624335e-07 3.68001106714707e-05 GO:0015399 primary active transmembrane transporter activity 13/276 166/18639 0.0783132530120482 5.28869827134625 1.19100580200318e-06 4.80372340141282e-05 GO:0031386 protein tag activity 5/276 15/18639 0.333333333333333 22.5108695652174 1.82606951752396e-06 6.31298318915427e-05 GO:0141047 molecular tag activity 5/276 15/18639 0.333333333333333 22.5108695652174 1.82606951752396e-06 6.31298318915427e-05 GO:0042056 chemoattractant activity 7/276 42/18639 0.166666666666667 11.2554347826087 2.50546962432269e-06 8.08431532114788e-05 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 5/276 18/18639 0.277777777777778 18.7590579710145 5.02353193339834e-06 0.0001519618409853 GO:0019864 IgG binding 4/276 11/18639 0.363636363636364 24.5573122529644 1.43040576043072e-05 0.000407244934146157 GO:0004601 peroxidase activity 7/276 57/18639 0.12280701754386 8.29347826086956 2.03176597245386e-05 0.000546319294815372 GO:0048306 calcium-dependent protein binding 8/276 80/18639 0.1 6.75326086956522 2.40801868797632e-05 0.000613411076305548 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 7/276 59/18639 0.11864406779661 8.0123434045689 2.55641819800245e-05 0.000618653203916592 GO:0008137 NADH dehydrogenase (ubiquinone) activity 6/276 41/18639 0.146341463414634 9.88282078472959 2.90481805682745e-05 0.000669491399764042 GO:0001540 amyloid-beta binding 8/276 83/18639 0.0963855421686747 6.50916710319539 3.15363879054388e-05 0.000693800533919654 GO:0019865 immunoglobulin binding 5/276 26/18639 0.192307692307692 12.9870401337793 3.50008559440232e-05 0.00073653975116988 GO:0045296 cadherin binding 16/276 334/18639 0.0479041916167665 3.23509502733663 4.10603787915638e-05 0.000817944730413441 GO:0015252 proton channel activity 5/276 27/18639 0.185185185185185 12.506038647343 4.2438433278272e-05 0.000817944730413441 GO:0003954 NADH dehydrogenase activity 6/276 44/18639 0.136363636363636 9.20899209486166 4.39391797329534e-05 0.000817944730413441 GO:0016651 oxidoreductase activity, acting on NAD(P)H 8/276 88/18639 0.0909090909090909 6.13932806324111 4.82202036160492e-05 0.000836146325155616 GO:0038024 cargo receptor activity 7/276 65/18639 0.107692307692308 7.27274247491639 4.83721014552835e-05 0.000836146325155616 GO:0004857 enzyme inhibitor activity 18/276 416/18639 0.0432692307692308 2.92208403010033 5.18884244716043e-05 0.000865999911870914 GO:0004129 cytochrome-c oxidase activity 4/276 15/18639 0.266666666666667 18.0086956521739 5.64615326991429e-05 0.000910912727546173 GO:0016675 oxidoreductase activity, acting on a heme group of donors 4/276 16/18639 0.25 16.883152173913 7.440737355519e-05 0.00116171512260361 GO:0019838 growth factor binding 9/276 136/18639 0.0661764705882353 4.46906969309463 0.000195409874962619 0.00295557435880961 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 6/276 58/18639 0.103448275862069 6.98613193403298 0.00021187998282027 0.00310757308136397 GO:0050840 extracellular matrix binding 6/276 67/18639 0.0895522388059701 6.04769630110318 0.000467525773089439 0.00665536688750849 GO:0050786 RAGE receptor binding 3/276 11/18639 0.272727272727273 18.4179841897233 0.000485277174213686 0.00671069006626927 GO:0008009 chemokine activity 5/276 45/18639 0.111111111111111 7.5036231884058 0.000516801318153053 0.00694810661072438 GO:0005044 scavenger receptor activity 4/276 27/18639 0.148148148148148 10.0048309178744 0.000631175702933219 0.00815116440494005 GO:0097371 MDM2/MDM4 family protein binding 3/276 12/18639 0.25 16.883152173913 0.000639967453280417 0.00815116440494005 GO:0005518 collagen binding 6/276 72/18639 0.0833333333333333 5.62771739130435 0.000688258052270919 0.00854145890510577 GO:0005125 cytokine activity 11/276 234/18639 0.047008547008547 3.17460981047938 0.000763038106622479 0.00923276109013199 GO:0003785 actin monomer binding 4/276 29/18639 0.137931034482759 9.31484257871064 0.000834573463521895 0.00985203795962433 GO:0005201 extracellular matrix structural constituent 9/276 168/18639 0.0535714285714286 3.61781832298137 0.000916143332230204 0.010557461257129 GO:0019763 immunoglobulin receptor activity 3/276 14/18639 0.214285714285714 14.4712732919255 0.0010358705879461 0.0116595666178119 GO:0033218 amide binding 11/276 247/18639 0.0445344129554656 3.00752508361204 0.00118417891225871 0.0130259680348458 GO:0022804 active transmembrane transporter activity 16/276 457/18639 0.0350109409190372 2.36438017315194 0.00135594459593341 0.0145839374318171 GO:0043394 proteoglycan binding 4/276 37/18639 0.108108108108108 7.30082256169213 0.00211524138449552 0.0222560180455615 GO:0008083 growth factor activity 8/276 162/18639 0.0493827160493827 3.33494363929147 0.00290171090669148 0.0298814484859292 GO:0005539 glycosaminoglycan binding 10/276 242/18639 0.0413223140495868 2.79060366510959 0.00336256454702879 0.0339058591825403 GO:0030020 extracellular matrix structural constituent conferring tensile strength 4/276 44/18639 0.0909090909090909 6.13932806324111 0.00401019587173492 0.0388620538730774 GO:0030021 extracellular matrix structural constituent conferring compression resistance 3/276 22/18639 0.136363636363636 9.20899209486166 0.00401550079320057 0.0388620538730774 GO:0042277 peptide binding 10/276 249/18639 0.0401606425702811 2.71215295966475 0.00411138576240774 0.0388620538730774 GO:0008201 heparin binding 8/276 172/18639 0.0465116279069767 3.14105156723964 0.00417526198636369 0.0388620538730774 GO:0042379 chemokine receptor binding 5/276 72/18639 0.0694444444444444 4.68976449275362 0.00428295747491045 0.0391122909029558 GO:0004602 glutathione peroxidase activity 3/276 23/18639 0.130434782608696 8.8086011342155 0.00456778061137546 0.040196469380104 GO:0017134 fibroblast growth factor binding 3/276 23/18639 0.130434782608696 8.8086011342155 0.00456778061137546 0.040196469380104 GO:0005504 fatty acid binding 4/276 47/18639 0.0851063829787234 5.74745605920444 0.00509013044010011 0.0439932702322938 GO:0030247 polysaccharide binding 3/276 26/18639 0.115384615384615 7.79222408026756 0.00649059316350666 0.0541628808816763 GO:0050750 low-density lipoprotein particle receptor binding 3/276 26/18639 0.115384615384615 7.79222408026756 0.00649059316350666 0.0541628808816763 GO:0004364 glutathione transferase activity 3/276 27/18639 0.111111111111111 7.5036231884058 0.00722302034607835 0.0592532516525749 GO:1901681 sulfur compound binding 10/276 275/18639 0.0363636363636364 2.45573122529644 0.00810861485910178 0.0654094931967543 GO:0043236 laminin binding 3/276 29/18639 0.103448275862069 6.98613193403298 0.00882950044895542 0.0687418706115261 GO:0140313 molecular sequestering activity 4/276 55/18639 0.0727272727272727 4.91146245059288 0.00887870851662833 0.0687418706115261 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/276 10/18639 0.2 13.5065217391304 0.00908983413044974 0.0687418706115261 GO:0031720 haptoglobin binding 2/276 10/18639 0.2 13.5065217391304 0.00908983413044974 0.0687418706115261 GO:0070325 lipoprotein particle receptor binding 3/276 31/18639 0.0967741935483871 6.53541374474053 0.0106288512065469 0.0783080532775744 GO:0008199 ferric iron binding 2/276 11/18639 0.181818181818182 12.2786561264822 0.0110019578985022 0.0783080532775744 GO:0010854 adenylate cyclase regulator activity 2/276 11/18639 0.181818181818182 12.2786561264822 0.0110019578985022 0.0783080532775744 GO:0048407 platelet-derived growth factor binding 2/276 11/18639 0.181818181818182 12.2786561264822 0.0110019578985022 0.0783080532775744 GO:0071813 lipoprotein particle binding 3/276 32/18639 0.09375 6.33118206521739 0.0116021442177405 0.080220540019806 GO:0071814 protein-lipid complex binding 3/276 32/18639 0.09375 6.33118206521739 0.0116021442177405 0.080220540019806 GO:0004859 phospholipase inhibitor activity 2/276 12/18639 0.166666666666667 11.2554347826087 0.0130743559875465 0.0878887263607294 GO:0010853 cyclase activator activity 2/276 12/18639 0.166666666666667 11.2554347826087 0.0130743559875465 0.0878887263607294 GO:0031625 ubiquitin protein ligase binding 10/276 302/18639 0.033112582781457 2.23617909588252 0.0149022419909287 0.0961833585446348 GO:0031432 titin binding 2/276 13/18639 0.153846153846154 10.3896321070234 0.0153018979502828 0.0961833585446348 GO:0035325 Toll-like receptor binding 2/276 13/18639 0.153846153846154 10.3896321070234 0.0153018979502828 0.0961833585446348 GO:0039706 co-receptor binding 2/276 13/18639 0.153846153846154 10.3896321070234 0.0153018979502828 0.0961833585446348 GO:0070700 BMP receptor binding 2/276 13/18639 0.153846153846154 10.3896321070234 0.0153018979502828 0.0961833585446348 GO:0044325 transmembrane transporter binding 6/276 136/18639 0.0441176470588235 2.97937979539642 0.0158669009332373 0.098456154508806 GO:0005344 oxygen carrier activity 2/276 14/18639 0.142857142857143 9.64751552795031 0.0176795691773389 0.106961393522901 GO:0044548 S100 protein binding 2/276 14/18639 0.142857142857143 9.64751552795031 0.0176795691773389 0.106961393522901 GO:0020037 heme binding 6/276 142/18639 0.0422535211267606 2.85349050826699 0.0192152886425831 0.114817280284077 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 2/276 15/18639 0.133333333333333 9.00434782608696 0.0202024686120437 0.119243839124746 GO:0044389 ubiquitin-like protein ligase binding 10/276 322/18639 0.031055900621118 2.09728598433702 0.0221785512394649 0.127207475280816 GO:0001530 lipopolysaccharide binding 3/276 41/18639 0.0731707317073171 4.94141039236479 0.0226296585951661 0.127207475280816 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/276 16/18639 0.125 8.44157608695652 0.0228658065070888 0.127207475280816 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/276 16/18639 0.125 8.44157608695652 0.0228658065070888 0.127207475280816 GO:0055102 lipase inhibitor activity 2/276 16/18639 0.125 8.44157608695652 0.0228658065070888 0.127207475280816 GO:0030169 low-density lipoprotein particle binding 2/276 17/18639 0.117647058823529 7.94501278772379 0.0256649022223475 0.138819232641389 GO:0070492 oligosaccharide binding 2/276 17/18639 0.117647058823529 7.94501278772379 0.0256649022223475 0.138819232641389 GO:0046906 tetrapyrrole binding 6/276 152/18639 0.0394736842105263 2.66576086956522 0.0258134936729856 0.138819232641389 GO:0003746 translation elongation factor activity 2/276 18/18639 0.111111111111111 7.5036231884058 0.0285951820631294 0.152088660643457 GO:0033293 monocarboxylic acid binding 4/276 79/18639 0.0506329113924051 3.41937259218492 0.0297641880784106 0.156585511195117 GO:0005520 insulin-like growth factor binding 2/276 19/18639 0.105263157894737 7.10869565217391 0.0316521771581639 0.159579726505743 GO:0015245 fatty acid transmembrane transporter activity 2/276 19/18639 0.105263157894737 7.10869565217391 0.0316521771581639 0.159579726505743 GO:0030506 ankyrin binding 2/276 19/18639 0.105263157894737 7.10869565217391 0.0316521771581639 0.159579726505743 GO:0043395 heparan sulfate proteoglycan binding 2/276 19/18639 0.105263157894737 7.10869565217391 0.0316521771581639 0.159579726505743 GO:0010851 cyclase regulator activity 2/276 20/18639 0.1 6.75326086956522 0.0348315213766164 0.172025064757983 GO:0016505 peptidase activator activity involved in apoptotic process 2/276 20/18639 0.1 6.75326086956522 0.0348315213766164 0.172025064757983 GO:0048020 CCR chemokine receptor binding 3/276 50/18639 0.06 4.05195652173913 0.0377869932633367 0.183462398531636 GO:0072542 protein phosphatase activator activity 2/276 21/18639 0.0952380952380952 6.43167701863354 0.0381289492834524 0.183462398531636 GO:0016874 ligase activity 6/276 167/18639 0.0359281437125748 2.42632127050247 0.0382845087844943 0.183462398531636 GO:0016860 intramolecular oxidoreductase activity 3/276 53/18639 0.0566037735849057 3.82260049220673 0.0437429131192691 0.207564411271826 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/276 24/18639 0.0833333333333333 5.62771739130435 0.0486885493332098 0.22878891142984 GO:0016504 peptidase activator activity 3/276 57/18639 0.0526315789473684 3.55434782608696 0.0523643024582245 0.239340749158368 GO:0001848 complement binding 2/276 25/18639 0.08 5.40260869565217 0.0524176020884029 0.239340749158368 GO:0019211 phosphatase activator activity 2/276 25/18639 0.08 5.40260869565217 0.0524176020884029 0.239340749158368 GO:0008198 ferrous iron binding 2/276 26/18639 0.0769230769230769 5.19481605351171 0.0562448528321442 0.254415969820166 GO:0023026 MHC class II protein complex binding 2/276 27/18639 0.0740740740740741 5.0024154589372 0.0601665994310295 0.269635501153873 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3/276 61/18639 0.0491803278688525 3.32127583749109 0.061738520483776 0.274141687285758 GO:0001968 fibronectin binding 2/276 30/18639 0.0666666666666667 4.50217391304348 0.0724630935207006 0.315965200576748 GO:0033612 receptor serine/threonine kinase binding 2/276 30/18639 0.0666666666666667 4.50217391304348 0.0724630935207006 0.315965200576748 GO:0019888 protein phosphatase regulator activity 4/276 107/18639 0.0373831775700935 2.5245835026412 0.0746849723995648 0.322745773583834 GO:0140375 immune receptor activity 5/276 156/18639 0.032051282051282 2.16450668896321 0.0825966229784919 0.35377668603177 GO:0140311 protein sequestering activity 2/276 33/18639 0.0606060606060606 4.09288537549407 0.0854849659891721 0.362936171392626 GO:0019825 oxygen binding 2/276 34/18639 0.0588235294117647 3.97250639386189 0.089971647777 0.375398944173 GO:0030332 cyclin binding 2/276 34/18639 0.0588235294117647 3.97250639386189 0.089971647777 0.375398944173 GO:0005178 integrin binding 5/276 161/18639 0.031055900621118 2.09728598433702 0.0915030157510363 0.378525295927364 GO:0043539 protein serine/threonine kinase activator activity 3/276 73/18639 0.0410958904109589 2.77531268612269 0.0940490763370829 0.38576061819617 GO:0019208 phosphatase regulator activity 4/276 117/18639 0.0341880341880342 2.30880713489409 0.0960380369593184 0.390608486456388 GO:0045505 dynein intermediate chain binding 2/276 36/18639 0.0555555555555556 3.7518115942029 0.0991456792301178 0.399887572894809 GO:0098631 cell adhesion mediator activity 3/276 76/18639 0.0394736842105263 2.66576086956522 0.103024771413251 0.411904427554374 GO:0023023 MHC protein complex binding 2/276 37/18639 0.0540540540540541 3.65041128084606 0.103827149094284 0.411904427554374 GO:0005501 retinoid binding 2/276 38/18639 0.0526315789473684 3.55434782608696 0.108567788165063 0.423764592515245 GO:0019840 isoprenoid binding 2/276 38/18639 0.0526315789473684 3.55434782608696 0.108567788165063 0.423764592515245 GO:0000217 DNA secondary structure binding 2/276 39/18639 0.0512820512820513 3.46321070234114 0.113364833812864 0.438948636523411 GO:0005126 cytokine receptor binding 7/276 275/18639 0.0254545454545455 1.71901185770751 0.115208094209198 0.442545377755966 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 2/276 40/18639 0.05 3.37663043478261 0.118215591712019 0.448786914244112 GO:0003779 actin binding 10/276 443/18639 0.0225733634311512 1.52443811954068 0.123610150695096 0.448786914244112 GO:0008135 translation factor activity, RNA binding 3/276 83/18639 0.036144578313253 2.44093766369827 0.125200888860356 0.448786914244112 GO:0005319 lipid transporter activity 5/276 178/18639 0.0280898876404494 1.89698339032731 0.125255044043076 0.448786914244112 GO:0008307 structural constituent of muscle 2/276 42/18639 0.0476190476190476 3.21583850931677 0.12806780007879 0.448786914244112 GO:0180051 translation factor activity 3/276 84/18639 0.0357142857142857 2.41187888198758 0.128499993598242 0.448786914244112 GO:0008200 ion channel inhibitor activity 2/276 43/18639 0.0465116279069767 3.14105156723964 0.133064190902761 0.448786914244112 GO:0048156 tau protein binding 2/276 43/18639 0.0465116279069767 3.14105156723964 0.133064190902761 0.448786914244112 GO:0016248 channel inhibitor activity 2/276 44/18639 0.0454545454545455 3.06966403162055 0.138104172011221 0.448786914244112 GO:0030547 signaling receptor inhibitor activity 2/276 44/18639 0.0454545454545455 3.06966403162055 0.138104172011221 0.448786914244112 GO:0001094 TFIID-class transcription factor complex binding 1/276 10/18639 0.1 6.75326086956522 0.138620574766992 0.448786914244112 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/276 10/18639 0.1 6.75326086956522 0.138620574766992 0.448786914244112 GO:0003796 lysozyme activity 1/276 10/18639 0.1 6.75326086956522 0.138620574766992 0.448786914244112 GO:0005522 profilin binding 1/276 10/18639 0.1 6.75326086956522 0.138620574766992 0.448786914244112 GO:0008239 dipeptidyl-peptidase activity 1/276 10/18639 0.1 6.75326086956522 0.138620574766992 0.448786914244112 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/276 10/18639 0.1 6.75326086956522 0.138620574766992 0.448786914244112 GO:0032395 MHC class II receptor activity 1/276 10/18639 0.1 6.75326086956522 0.138620574766992 0.448786914244112 GO:0047429 nucleoside triphosphate diphosphatase activity 1/276 10/18639 0.1 6.75326086956522 0.138620574766992 0.448786914244112 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/276 10/18639 0.1 6.75326086956522 0.138620574766992 0.448786914244112 GO:0051880 G-quadruplex DNA binding 1/276 10/18639 0.1 6.75326086956522 0.138620574766992 0.448786914244112 GO:0070513 death domain binding 1/276 10/18639 0.1 6.75326086956522 0.138620574766992 0.448786914244112 GO:0004197 cysteine-type endopeptidase activity 3/276 88/18639 0.0340909090909091 2.30224802371542 0.141997029263641 0.448786914244112 GO:0141110 transporter inhibitor activity 2/276 45/18639 0.0444444444444444 3.00144927536232 0.143185370046548 0.448786914244112 GO:0002020 protease binding 4/276 136/18639 0.0294117647058824 1.98625319693095 0.143370035070335 0.448786914244112 GO:0031406 carboxylic acid binding 5/276 187/18639 0.0267379679144385 1.80568472448268 0.145147104050921 0.448786914244112 GO:0043177 organic acid binding 5/276 189/18639 0.0264550264550265 1.78657694962043 0.149743005219098 0.448786914244112 GO:0001851 complement component C3b binding 1/276 11/18639 0.0909090909090909 6.13932806324111 0.151382436453841 0.448786914244112 GO:0008046 axon guidance receptor activity 1/276 11/18639 0.0909090909090909 6.13932806324111 0.151382436453841 0.448786914244112 GO:0015173 aromatic amino acid transmembrane transporter activity 1/276 11/18639 0.0909090909090909 6.13932806324111 0.151382436453841 0.448786914244112 GO:0015217 ADP transmembrane transporter activity 1/276 11/18639 0.0909090909090909 6.13932806324111 0.151382436453841 0.448786914244112 GO:0019215 intermediate filament binding 1/276 11/18639 0.0909090909090909 6.13932806324111 0.151382436453841 0.448786914244112 GO:0032794 GTPase activating protein binding 1/276 11/18639 0.0909090909090909 6.13932806324111 0.151382436453841 0.448786914244112 GO:0042608 T cell receptor binding 1/276 11/18639 0.0909090909090909 6.13932806324111 0.151382436453841 0.448786914244112 GO:0047676 arachidonate-CoA ligase activity 1/276 11/18639 0.0909090909090909 6.13932806324111 0.151382436453841 0.448786914244112 GO:0050998 nitric-oxide synthase binding 1/276 11/18639 0.0909090909090909 6.13932806324111 0.151382436453841 0.448786914244112 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/276 11/18639 0.0909090909090909 6.13932806324111 0.151382436453841 0.448786914244112 GO:0030295 protein kinase activator activity 4/276 139/18639 0.0287769784172662 1.94338442289647 0.151561628133863 0.448786914244112 GO:0072341 modified amino acid binding 3/276 91/18639 0.032967032967033 2.2263497372193 0.152416387833268 0.448786914244112 GO:0001664 G protein-coupled receptor binding 7/276 297/18639 0.0235690235690236 1.59167764602547 0.152995538946856 0.448786914244112 GO:0038187 pattern recognition receptor activity 2/276 48/18639 0.0416666666666667 2.81385869565217 0.158653428563826 0.461364272001024 GO:0005049 nuclear export signal receptor activity 1/276 12/18639 0.0833333333333333 5.62771739130435 0.163955898314413 0.461364272001024 GO:0005095 GTPase inhibitor activity 1/276 12/18639 0.0833333333333333 5.62771739130435 0.163955898314413 0.461364272001024 GO:0008179 adenylate cyclase binding 1/276 12/18639 0.0833333333333333 5.62771739130435 0.163955898314413 0.461364272001024 GO:0015368 calcium:monoatomic cation antiporter activity 1/276 12/18639 0.0833333333333333 5.62771739130435 0.163955898314413 0.461364272001024 GO:0035259 nuclear glucocorticoid receptor binding 1/276 12/18639 0.0833333333333333 5.62771739130435 0.163955898314413 0.461364272001024 GO:0035497 cAMP response element binding 1/276 12/18639 0.0833333333333333 5.62771739130435 0.163955898314413 0.461364272001024 GO:0016829 lyase activity 5/276 200/18639 0.025 1.6883152173913 0.176074490354898 0.481681546183202 GO:0005542 folic acid binding 1/276 13/18639 0.0769230769230769 5.19481605351171 0.176343731678091 0.481681546183202 GO:0008035 high-density lipoprotein particle binding 1/276 13/18639 0.0769230769230769 5.19481605351171 0.176343731678091 0.481681546183202 GO:0019855 calcium channel inhibitor activity 1/276 13/18639 0.0769230769230769 5.19481605351171 0.176343731678091 0.481681546183202 GO:0031994 insulin-like growth factor I binding 1/276 13/18639 0.0769230769230769 5.19481605351171 0.176343731678091 0.481681546183202 GO:0019209 kinase activator activity 4/276 148/18639 0.027027027027027 1.82520564042303 0.177147345497128 0.481681546183202 GO:0019887 protein kinase regulator activity 6/276 255/18639 0.0235294117647059 1.58900255754476 0.178300633534683 0.482108975590987 GO:0005080 protein kinase C binding 2/276 52/18639 0.0384615384615385 2.59740802675585 0.179720812198609 0.483249295022926 GO:0004864 protein phosphatase inhibitor activity 2/276 53/18639 0.0377358490566038 2.54840032813782 0.185053278829171 0.490632015868037 GO:0005161 platelet-derived growth factor receptor binding 1/276 14/18639 0.0714285714285714 4.82375776397516 0.188548667255072 0.490632015868037 GO:0005347 ATP transmembrane transporter activity 1/276 14/18639 0.0714285714285714 4.82375776397516 0.188548667255072 0.490632015868037 GO:0016530 metallochaperone activity 1/276 14/18639 0.0714285714285714 4.82375776397516 0.188548667255072 0.490632015868037 GO:0031404 chloride ion binding 1/276 14/18639 0.0714285714285714 4.82375776397516 0.188548667255072 0.490632015868037 GO:0061783 peptidoglycan muralytic activity 1/276 14/18639 0.0714285714285714 4.82375776397516 0.188548667255072 0.490632015868037 GO:0098632 cell-cell adhesion mediator activity 2/276 55/18639 0.0363636363636364 2.45573122529644 0.195783656523654 0.501907919052985 GO:0000774 adenyl-nucleotide exchange factor activity 1/276 15/18639 0.0666666666666667 4.50217391304348 0.200573395729574 0.501907919052985 GO:0004467 long-chain fatty acid-CoA ligase activity 1/276 15/18639 0.0666666666666667 4.50217391304348 0.200573395729574 0.501907919052985 GO:0005041 low-density lipoprotein particle receptor activity 1/276 15/18639 0.0666666666666667 4.50217391304348 0.200573395729574 0.501907919052985 GO:0005523 tropomyosin binding 1/276 15/18639 0.0666666666666667 4.50217391304348 0.200573395729574 0.501907919052985 GO:0016846 carbon-sulfur lyase activity 1/276 15/18639 0.0666666666666667 4.50217391304348 0.200573395729574 0.501907919052985 GO:0019212 phosphatase inhibitor activity 2/276 56/18639 0.0357142857142857 2.41187888198758 0.201177967554296 0.501907919052985 GO:0170055 lipid transmembrane transporter activity 2/276 56/18639 0.0357142857142857 2.41187888198758 0.201177967554296 0.501907919052985 GO:0000062 fatty-acyl-CoA binding 1/276 16/18639 0.0625 4.22078804347826 0.212420568344406 0.521886066389303 GO:0016722 oxidoreductase activity, acting on metal ions 1/276 16/18639 0.0625 4.22078804347826 0.212420568344406 0.521886066389303 GO:0019841 retinol binding 1/276 16/18639 0.0625 4.22078804347826 0.212420568344406 0.521886066389303 GO:0001786 phosphatidylserine binding 2/276 59/18639 0.0338983050847458 2.28924097273397 0.217456791223899 0.523965768013937 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/276 17/18639 0.0588235294117647 3.97250639386189 0.224092797477035 0.523965768013937 GO:0004550 nucleoside diphosphate kinase activity 1/276 17/18639 0.0588235294117647 3.97250639386189 0.224092797477035 0.523965768013937 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/276 17/18639 0.0588235294117647 3.97250639386189 0.224092797477035 0.523965768013937 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/276 17/18639 0.0588235294117647 3.97250639386189 0.224092797477035 0.523965768013937 GO:0016018 cyclosporin A binding 1/276 17/18639 0.0588235294117647 3.97250639386189 0.224092797477035 0.523965768013937 GO:0019198 transmembrane receptor protein phosphatase activity 1/276 17/18639 0.0588235294117647 3.97250639386189 0.224092797477035 0.523965768013937 GO:0036041 long-chain fatty acid binding 1/276 17/18639 0.0588235294117647 3.97250639386189 0.224092797477035 0.523965768013937 GO:0045236 CXCR chemokine receptor binding 1/276 17/18639 0.0588235294117647 3.97250639386189 0.224092797477035 0.523965768013937 GO:1901567 fatty acid derivative binding 1/276 17/18639 0.0588235294117647 3.97250639386189 0.224092797477035 0.523965768013937 GO:0043022 ribosome binding 3/276 112/18639 0.0267857142857143 1.80890916149068 0.230893292797947 0.527902065223686 GO:0000400 four-way junction DNA binding 1/276 18/18639 0.0555555555555556 3.7518115942029 0.235592657207265 0.527902065223686 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/276 18/18639 0.0555555555555556 3.7518115942029 0.235592657207265 0.527902065223686 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/276 18/18639 0.0555555555555556 3.7518115942029 0.235592657207265 0.527902065223686 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/276 18/18639 0.0555555555555556 3.7518115942029 0.235592657207265 0.527902065223686 GO:0030228 lipoprotein particle receptor activity 1/276 18/18639 0.0555555555555556 3.7518115942029 0.235592657207265 0.527902065223686 GO:0035615 clathrin adaptor activity 1/276 18/18639 0.0555555555555556 3.7518115942029 0.235592657207265 0.527902065223686 GO:0070064 proline-rich region binding 1/276 18/18639 0.0555555555555556 3.7518115942029 0.235592657207265 0.527902065223686 GO:0098641 cadherin binding involved in cell-cell adhesion 1/276 18/18639 0.0555555555555556 3.7518115942029 0.235592657207265 0.527902065223686 GO:0005507 copper ion binding 2/276 63/18639 0.0317460317460317 2.14389233954451 0.239325799386832 0.533795792180769 GO:0061134 peptidase regulator activity 5/276 226/18639 0.0221238938053097 1.49408426317815 0.244268371503262 0.535921878907189 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/276 19/18639 0.0526315789473684 3.55434782608696 0.246922683876659 0.535921878907189 GO:0008301 DNA binding, bending 1/276 19/18639 0.0526315789473684 3.55434782608696 0.246922683876659 0.535921878907189 GO:0016918 retinal binding 1/276 19/18639 0.0526315789473684 3.55434782608696 0.246922683876659 0.535921878907189 GO:0070003 threonine-type peptidase activity 1/276 19/18639 0.0526315789473684 3.55434782608696 0.246922683876659 0.535921878907189 GO:0120227 acyl-CoA binding 1/276 19/18639 0.0526315789473684 3.55434782608696 0.246922683876659 0.535921878907189 GO:0019207 kinase regulator activity 6/276 287/18639 0.0209059233449477 1.41183154067566 0.253108122561654 0.546894336249287 GO:0001972 retinoic acid binding 1/276 20/18639 0.05 3.37663043478261 0.258085376639819 0.550278952835562 GO:0016004 phospholipase activator activity 1/276 20/18639 0.05 3.37663043478261 0.258085376639819 0.550278952835562 GO:0043024 ribosomal small subunit binding 1/276 20/18639 0.05 3.37663043478261 0.258085376639819 0.550278952835562 GO:0004252 serine-type endopeptidase activity 4/276 176/18639 0.0227272727272727 1.53483201581028 0.264262416481638 0.556565247161097 GO:0051082 unfolded protein binding 3/276 121/18639 0.0247933884297521 1.67436219906576 0.266544885220208 0.556565247161097 GO:0043021 ribonucleoprotein complex binding 4/276 177/18639 0.0225988700564972 1.52616064848931 0.267525648466513 0.556565247161097 GO:0001846 opsonin binding 1/276 21/18639 0.0476190476190476 3.21583850931677 0.269083198007638 0.556565247161097 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/276 21/18639 0.0476190476190476 3.21583850931677 0.269083198007638 0.556565247161097 GO:0070182 DNA polymerase binding 1/276 21/18639 0.0476190476190476 3.21583850931677 0.269083198007638 0.556565247161097 GO:0140312 cargo adaptor activity 1/276 21/18639 0.0476190476190476 3.21583850931677 0.269083198007638 0.556565247161097 GO:0016853 isomerase activity 4/276 180/18639 0.0222222222222222 1.50072463768116 0.277358271514121 0.569700545320193 GO:0008028 monocarboxylic acid transmembrane transporter activity 2/276 70/18639 0.0285714285714286 1.92950310559006 0.277787869205714 0.569700545320193 GO:0061133 endopeptidase activator activity 1/276 22/18639 0.0454545454545455 3.06966403162055 0.279918574382645 0.571648059076795 GO:0000295 adenine nucleotide transmembrane transporter activity 1/276 23/18639 0.0434782608695652 2.93620037807183 0.290593896586566 0.583599360779659 GO:0005158 insulin receptor binding 1/276 23/18639 0.0434782608695652 2.93620037807183 0.290593896586566 0.583599360779659 GO:0005212 structural constituent of eye lens 1/276 23/18639 0.0434782608695652 2.93620037807183 0.290593896586566 0.583599360779659 GO:0099186 structural constituent of postsynapse 1/276 23/18639 0.0434782608695652 2.93620037807183 0.290593896586566 0.583599360779659 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/276 24/18639 0.0416666666666667 2.81385869565217 0.30111152038019 0.58765312848392 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/276 24/18639 0.0416666666666667 2.81385869565217 0.30111152038019 0.58765312848392 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/276 24/18639 0.0416666666666667 2.81385869565217 0.30111152038019 0.58765312848392 GO:0004622 lysophospholipase activity 1/276 24/18639 0.0416666666666667 2.81385869565217 0.30111152038019 0.58765312848392 GO:0005540 hyaluronic acid binding 1/276 24/18639 0.0416666666666667 2.81385869565217 0.30111152038019 0.58765312848392 GO:0050431 transforming growth factor beta binding 1/276 24/18639 0.0416666666666667 2.81385869565217 0.30111152038019 0.58765312848392 GO:0060229 lipase activator activity 1/276 24/18639 0.0416666666666667 2.81385869565217 0.30111152038019 0.58765312848392 GO:0019003 GDP binding 2/276 75/18639 0.0266666666666667 1.80086956521739 0.305208284542007 0.593256263929041 GO:0046982 protein heterodimerization activity 7/276 369/18639 0.018970189701897 1.2811063980205 0.306812472686719 0.59351694179618 GO:0003707 nuclear steroid receptor activity 1/276 25/18639 0.04 2.70130434782609 0.311473766975681 0.59351694179618 GO:0015645 fatty acid ligase activity 1/276 25/18639 0.04 2.70130434782609 0.311473766975681 0.59351694179618 GO:0120020 cholesterol transfer activity 1/276 25/18639 0.04 2.70130434782609 0.311473766975681 0.59351694179618 GO:0120515 fatty acid-CoA ligase activity 1/276 25/18639 0.04 2.70130434782609 0.311473766975681 0.59351694179618 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/276 26/18639 0.0384615384615385 2.59740802675585 0.321682923541423 0.601137200749223 GO:0005112 Notch binding 1/276 26/18639 0.0384615384615385 2.59740802675585 0.321682923541423 0.601137200749223 GO:0015216 purine nucleotide transmembrane transporter activity 1/276 26/18639 0.0384615384615385 2.59740802675585 0.321682923541423 0.601137200749223 GO:0030507 spectrin binding 1/276 26/18639 0.0384615384615385 2.59740802675585 0.321682923541423 0.601137200749223 GO:0050681 nuclear androgen receptor binding 1/276 26/18639 0.0384615384615385 2.59740802675585 0.321682923541423 0.601137200749223 GO:0008236 serine-type peptidase activity 4/276 194/18639 0.0206185567010309 1.39242492155984 0.323883631056189 0.60135865899088 GO:0046332 SMAD binding 2/276 79/18639 0.0253164556962025 1.70968629609246 0.327009013204956 0.60135865899088 GO:0003713 transcription coactivator activity 5/276 256/18639 0.01953125 1.31899626358696 0.329745777195569 0.60135865899088 GO:0008320 protein transmembrane transporter activity 1/276 27/18639 0.037037037037037 2.5012077294686 0.331741243699515 0.60135865899088 GO:0008395 steroid hydroxylase activity 1/276 27/18639 0.037037037037037 2.5012077294686 0.331741243699515 0.60135865899088 GO:0016405 CoA-ligase activity 1/276 27/18639 0.037037037037037 2.5012077294686 0.331741243699515 0.60135865899088 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/276 27/18639 0.037037037037037 2.5012077294686 0.331741243699515 0.60135865899088 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/276 27/18639 0.037037037037037 2.5012077294686 0.331741243699515 0.60135865899088 GO:0017171 serine hydrolase activity 4/276 198/18639 0.0202020202020202 1.36429512516469 0.337298061356028 0.60915023021014 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/276 29/18639 0.0344827586206897 2.32871064467766 0.351414224484115 0.630830623956845 GO:0004527 exonuclease activity 2/276 84/18639 0.0238095238095238 1.60791925465839 0.353993831799922 0.630830623956845 GO:0004860 protein kinase inhibitor activity 2/276 84/18639 0.0238095238095238 1.60791925465839 0.353993831799922 0.630830623956845 GO:0019955 cytokine binding 3/276 144/18639 0.0208333333333333 1.40692934782609 0.359468716327754 0.630830623956845 GO:0015215 nucleotide transmembrane transporter activity 1/276 30/18639 0.0333333333333333 2.25108695652174 0.361033229000095 0.630830623956845 GO:0016769 transferase activity, transferring nitrogenous groups 1/276 30/18639 0.0333333333333333 2.25108695652174 0.361033229000095 0.630830623956845 GO:0031210 phosphatidylcholine binding 1/276 30/18639 0.0333333333333333 2.25108695652174 0.361033229000095 0.630830623956845 GO:0048019 receptor antagonist activity 1/276 30/18639 0.0333333333333333 2.25108695652174 0.361033229000095 0.630830623956845 GO:0098918 structural constituent of synapse 1/276 30/18639 0.0333333333333333 2.25108695652174 0.361033229000095 0.630830623956845 GO:0008081 phosphoric diester hydrolase activity 2/276 87/18639 0.0229885057471264 1.55247376311844 0.370004385580918 0.63395135804508 GO:0005184 neuropeptide hormone activity 1/276 31/18639 0.032258064516129 2.17847124824684 0.370510085832594 0.63395135804508 GO:0016878 acid-thiol ligase activity 1/276 31/18639 0.032258064516129 2.17847124824684 0.370510085832594 0.63395135804508 GO:0047499 calcium-independent phospholipase A2 activity 1/276 31/18639 0.032258064516129 2.17847124824684 0.370510085832594 0.63395135804508 GO:0051015 actin filament binding 4/276 209/18639 0.0191387559808612 1.29249011857707 0.374251582774749 0.63395135804508 GO:0022884 macromolecule transmembrane transporter activity 1/276 32/18639 0.03125 2.11039402173913 0.379846888084862 0.63395135804508 GO:0031369 translation initiation factor binding 1/276 32/18639 0.03125 2.11039402173913 0.379846888084862 0.63395135804508 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/276 32/18639 0.03125 2.11039402173913 0.379846888084862 0.63395135804508 GO:0043425 bHLH transcription factor binding 1/276 32/18639 0.03125 2.11039402173913 0.379846888084862 0.63395135804508 GO:0051059 NF-kappaB binding 1/276 32/18639 0.03125 2.11039402173913 0.379846888084862 0.63395135804508 GO:0120015 sterol transfer activity 1/276 32/18639 0.03125 2.11039402173913 0.379846888084862 0.63395135804508 GO:0140142 nucleocytoplasmic carrier activity 1/276 32/18639 0.03125 2.11039402173913 0.379846888084862 0.63395135804508 GO:0160041 neuropeptide activity 1/276 32/18639 0.03125 2.11039402173913 0.379846888084862 0.63395135804508 GO:0019210 kinase inhibitor activity 2/276 90/18639 0.0222222222222222 1.50072463768116 0.385856443209491 0.641768104857023 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/276 33/18639 0.0303030303030303 2.04644268774704 0.389045698150352 0.642655692507749 GO:0019956 chemokine binding 1/276 33/18639 0.0303030303030303 2.04644268774704 0.389045698150352 0.642655692507749 GO:0043178 alcohol binding 2/276 92/18639 0.0217391304347826 1.46810018903592 0.396328063064224 0.649814107947859 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/276 34/18639 0.0294117647058824 1.98625319693095 0.398108548161666 0.649814107947859 GO:0016831 carboxy-lyase activity 1/276 34/18639 0.0294117647058824 1.98625319693095 0.398108548161666 0.649814107947859 GO:0005506 iron ion binding 3/276 154/18639 0.0194805194805195 1.31557029926595 0.399599781710687 0.649814107947859 GO:0030246 carbohydrate binding 5/276 280/18639 0.0178571428571429 1.20593944099379 0.400092157372855 0.649814107947859 GO:0042562 hormone binding 2/276 94/18639 0.0212765957446809 1.43686401480111 0.406717207226392 0.654505385945353 GO:0004623 phospholipase A2 activity 1/276 35/18639 0.0285714285714286 1.92950310559006 0.407037440432957 0.654505385945353 GO:0016229 steroid dehydrogenase activity 1/276 35/18639 0.0285714285714286 1.92950310559006 0.407037440432957 0.654505385945353 GO:0004869 cysteine-type endopeptidase inhibitor activity 1/276 36/18639 0.0277777777777778 1.87590579710145 0.415834347895896 0.659881391415126 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/276 36/18639 0.0277777777777778 1.87590579710145 0.415834347895896 0.659881391415126 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/276 36/18639 0.0277777777777778 1.87590579710145 0.415834347895896 0.659881391415126 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/276 36/18639 0.0277777777777778 1.87590579710145 0.415834347895896 0.659881391415126 GO:0099106 ion channel regulator activity 3/276 160/18639 0.01875 1.26623641304348 0.42335605913583 0.669246214437031 GO:0022829 wide pore channel activity 1/276 37/18639 0.027027027027027 1.82520564042303 0.424501214529274 0.669246214437031 GO:0000146 microfilament motor activity 1/276 38/18639 0.0263157894736842 1.77717391304348 0.433039955782361 0.67828912167852 GO:0005109 frizzled binding 1/276 38/18639 0.0263157894736842 1.77717391304348 0.433039955782361 0.67828912167852 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/276 39/18639 0.0256410256410256 1.73160535117057 0.441452458992084 0.687019260939449 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/276 39/18639 0.0256410256410256 1.73160535117057 0.441452458992084 0.687019260939449 GO:0015036 disulfide oxidoreductase activity 1/276 40/18639 0.025 1.6883152173913 0.449740583794137 0.688281312619864 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1/276 40/18639 0.025 1.6883152173913 0.449740583794137 0.688281312619864 GO:0050997 quaternary ammonium group binding 1/276 40/18639 0.025 1.6883152173913 0.449740583794137 0.688281312619864 GO:0071855 neuropeptide receptor binding 1/276 40/18639 0.025 1.6883152173913 0.449740583794137 0.688281312619864 GO:0016247 channel regulator activity 3/276 168/18639 0.0178571428571429 1.20593944099379 0.454513782386646 0.688281312619864 GO:0016877 ligase activity, forming carbon-sulfur bonds 1/276 41/18639 0.024390243902439 1.64713679745493 0.457906162528092 0.688281312619864 GO:0017080 sodium channel regulator activity 1/276 41/18639 0.024390243902439 1.64713679745493 0.457906162528092 0.688281312619864 GO:0042169 SH2 domain binding 1/276 41/18639 0.024390243902439 1.64713679745493 0.457906162528092 0.688281312619864 GO:0042287 MHC protein binding 1/276 41/18639 0.024390243902439 1.64713679745493 0.457906162528092 0.688281312619864 GO:0140318 protein transporter activity 1/276 41/18639 0.024390243902439 1.64713679745493 0.457906162528092 0.688281312619864 GO:0140828 metal cation:monoatomic cation antiporter activity 1/276 41/18639 0.024390243902439 1.64713679745493 0.457906162528092 0.688281312619864 GO:0141108 transporter regulator activity 3/276 170/18639 0.0176470588235294 1.19175191815857 0.462196126793459 0.692578716309703 GO:0016859 cis-trans isomerase activity 1/276 42/18639 0.0238095238095238 1.60791925465839 0.465951000636611 0.693908567101907 GO:0048487 beta-tubulin binding 1/276 42/18639 0.0238095238095238 1.60791925465839 0.465951000636611 0.693908567101907 GO:0005496 steroid binding 2/276 108/18639 0.0185185185185185 1.2506038647343 0.476816908764782 0.707912220374707 GO:0004620 phospholipase activity 2/276 109/18639 0.018348623853211 1.23913043478261 0.481631955024709 0.708619463815066 GO:0001223 transcription coactivator binding 1/276 44/18639 0.0227272727272727 1.53483201581028 0.481685544618093 0.708619463815066 GO:0019205 nucleobase-containing compound kinase activity 1/276 44/18639 0.0227272727272727 1.53483201581028 0.481685544618093 0.708619463815066 GO:0042605 peptide antigen binding 1/276 45/18639 0.0222222222222222 1.50072463768116 0.48937873040381 0.713431643118807 GO:0051539 4 iron, 4 sulfur cluster binding 1/276 45/18639 0.0222222222222222 1.50072463768116 0.48937873040381 0.713431643118807 GO:0140303 intramembrane lipid transporter activity 1/276 45/18639 0.0222222222222222 1.50072463768116 0.48937873040381 0.713431643118807 GO:0005200 structural constituent of cytoskeleton 2/276 112/18639 0.0178571428571429 1.20593944099379 0.495912458274079 0.717993247449731 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/276 46/18639 0.0217391304347826 1.46810018903592 0.496958136148058 0.717993247449731 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1/276 46/18639 0.0217391304347826 1.46810018903592 0.496958136148058 0.717993247449731 GO:0001784 phosphotyrosine residue binding 1/276 47/18639 0.0212765957446809 1.43686401480111 0.50442543859646 0.721257815909134 GO:0043495 protein-membrane adaptor activity 1/276 47/18639 0.0212765957446809 1.43686401480111 0.50442543859646 0.721257815909134 GO:0061733 protein-lysine-acetyltransferase activity 1/276 47/18639 0.0212765957446809 1.43686401480111 0.50442543859646 0.721257815909134 GO:0140104 molecular carrier activity 4/276 249/18639 0.0160642570281124 1.0848611838659 0.505178511556191 0.721257815909134 GO:0001221 transcription coregulator binding 2/276 115/18639 0.0173913043478261 1.17448015122873 0.509941169412853 0.725916252928885 GO:0140693 molecular condensate scaffold activity 1/276 48/18639 0.0208333333333333 1.40692934782609 0.51178228987375 0.726400669498225 GO:0061135 endopeptidase regulator activity 3/276 184/18639 0.016304347826087 1.10107514177694 0.514564301093775 0.728213806226278 GO:0001222 transcription corepressor binding 1/276 49/18639 0.0204081632653061 1.3782165039929 0.519030317843996 0.730263586733994 GO:0060590 ATPase regulator activity 1/276 49/18639 0.0204081632653061 1.3782165039929 0.519030317843996 0.730263586733994 GO:0008234 cysteine-type peptidase activity 3/276 187/18639 0.0160427807486631 1.08341083468961 0.525433607638607 0.735247428296912 GO:0015605 organophosphate ester transmembrane transporter activity 1/276 50/18639 0.02 1.35065217391304 0.52617112646557 0.735247428296912 GO:0046943 carboxylic acid transmembrane transporter activity 3/276 188/18639 0.0159574468085106 1.07764801110083 0.529027005087744 0.735247428296912 GO:0005342 organic acid transmembrane transporter activity 3/276 189/18639 0.0158730158730159 1.07194616977226 0.532605301808591 0.735247428296912 GO:0003743 translation initiation factor activity 1/276 51/18639 0.0196078431372549 1.32416879795396 0.533206296140942 0.735247428296912 GO:0005048 signal sequence binding 1/276 51/18639 0.0196078431372549 1.32416879795396 0.533206296140942 0.735247428296912 GO:0016830 carbon-carbon lyase activity 1/276 51/18639 0.0196078431372549 1.32416879795396 0.533206296140942 0.735247428296912 GO:0019902 phosphatase binding 3/276 190/18639 0.0157894736842105 1.06630434782609 0.536168355648141 0.737231489016194 GO:0005246 calcium channel regulator activity 1/276 53/18639 0.0188679245283019 1.27420016406891 0.546965924546615 0.740297292319634 GO:0005544 calcium-dependent phospholipid binding 1/276 53/18639 0.0188679245283019 1.27420016406891 0.546965924546615 0.740297292319634 GO:0034212 protein N-acetyltransferase activity 1/276 53/18639 0.0188679245283019 1.27420016406891 0.546965924546615 0.740297292319634 GO:0140296 general transcription initiation factor binding 1/276 53/18639 0.0188679245283019 1.27420016406891 0.546965924546615 0.740297292319634 GO:1901505 carbohydrate derivative transmembrane transporter activity 1/276 53/18639 0.0188679245283019 1.27420016406891 0.546965924546615 0.740297292319634 GO:0003925 G protein activity 1/276 54/18639 0.0185185185185185 1.2506038647343 0.553693429379561 0.740297292319634 GO:0015485 cholesterol binding 1/276 54/18639 0.0185185185185185 1.2506038647343 0.553693429379561 0.740297292319634 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 1/276 54/18639 0.0185185185185185 1.2506038647343 0.553693429379561 0.740297292319634 GO:0050661 NADP binding 1/276 54/18639 0.0185185185185185 1.2506038647343 0.553693429379561 0.740297292319634 GO:0051287 NAD binding 1/276 54/18639 0.0185185185185185 1.2506038647343 0.553693429379561 0.740297292319634 GO:0004175 endopeptidase activity 6/276 405/18639 0.0148148148148148 1.00048309178744 0.556800223901721 0.742400298535628 GO:0042826 histone deacetylase binding 2/276 127/18639 0.015748031496063 1.06350564875043 0.563444363743538 0.74919525288976 GO:0008514 organic anion transmembrane transporter activity 4/276 269/18639 0.0148698884758364 1.00420235978665 0.566084771855753 0.750643916652561 GO:0005261 monoatomic cation channel activity 5/276 341/18639 0.0146627565982405 0.990214203748566 0.571167739034328 0.754044758442752 GO:0015932 nucleobase-containing compound transmembrane transporter activity 1/276 57/18639 0.0175438596491228 1.18478260869565 0.573284516634521 0.754044758442752 GO:0016298 lipase activity 2/276 130/18639 0.0153846153846154 1.03896321070234 0.576151378958083 0.754044758442752 GO:0031072 heat shock protein binding 2/276 131/18639 0.0152671755725191 1.03103219382675 0.580326829174795 0.754044758442752 GO:0003714 transcription corepressor activity 3/276 204/18639 0.0147058823529412 0.993126598465473 0.584381351419 0.754044758442752 GO:0004879 nuclear receptor activity 1/276 59/18639 0.0169491525423729 1.14462048636699 0.585866794742649 0.754044758442752 GO:0045309 protein phosphorylated amino acid binding 1/276 59/18639 0.0169491525423729 1.14462048636699 0.585866794742649 0.754044758442752 GO:0070063 RNA polymerase binding 1/276 59/18639 0.0169491525423729 1.14462048636699 0.585866794742649 0.754044758442752 GO:0070888 E-box binding 1/276 59/18639 0.0169491525423729 1.14462048636699 0.585866794742649 0.754044758442752 GO:0140297 DNA-binding transcription factor binding 7/276 488/18639 0.014344262295082 0.968705452601568 0.587061083885398 0.754044758442752 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 5/276 349/18639 0.0143266475644699 0.967515883891865 0.59178913349888 0.754044758442752 GO:0001098 basal transcription machinery binding 1/276 60/18639 0.0166666666666667 1.12554347826087 0.592018612000508 0.754044758442752 GO:0001099 basal RNA polymerase II transcription machinery binding 1/276 60/18639 0.0166666666666667 1.12554347826087 0.592018612000508 0.754044758442752 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 1/276 60/18639 0.0166666666666667 1.12554347826087 0.592018612000508 0.754044758442752 GO:0098531 ligand-modulated transcription factor activity 1/276 60/18639 0.0166666666666667 1.12554347826087 0.592018612000508 0.754044758442752 GO:0015297 antiporter activity 2/276 135/18639 0.0148148148148148 1.00048309178744 0.596726697958174 0.755797431142678 GO:0015026 coreceptor activity 1/276 61/18639 0.0163934426229508 1.10709194583036 0.598079372164557 0.755797431142678 GO:0016836 hydro-lyase activity 1/276 61/18639 0.0163934426229508 1.10709194583036 0.598079372164557 0.755797431142678 GO:0004518 nuclease activity 3/276 209/18639 0.0143540669856459 0.969367588932806 0.600812566719908 0.756322283566062 GO:0003712 transcription coregulator activity 7/276 495/18639 0.0141414141414141 0.955006587615283 0.602111036182009 0.756322283566062 GO:0015179 L-amino acid transmembrane transporter activity 1/276 62/18639 0.0161290322580645 1.08923562412342 0.604050418201944 0.756322283566062 GO:0016922 nuclear receptor binding 2/276 137/18639 0.0145985401459854 0.985877499206601 0.604745296983608 0.756322283566062 GO:0005543 phospholipid binding 7/276 497/18639 0.0140845070422535 0.951163502755664 0.606359065906785 0.756386051285784 GO:0120013 lipid transfer activity 1/276 65/18639 0.0153846153846154 1.03896321070234 0.621438406919857 0.773203570563524 GO:0019903 protein phosphatase binding 2/276 144/18639 0.0138888888888889 0.937952898550725 0.631859839774431 0.784154262694422 GO:0003777 microtubule motor activity 1/276 68/18639 0.0147058823529412 0.993126598465473 0.638065453288652 0.785810889037424 GO:0032934 sterol binding 1/276 68/18639 0.0147058823529412 0.993126598465473 0.638065453288652 0.785810889037424 GO:1990841 promoter-specific chromatin binding 1/276 68/18639 0.0147058823529412 0.993126598465473 0.638065453288652 0.785810889037424 GO:0008080 N-acetyltransferase activity 1/276 69/18639 0.0144927536231884 0.978733459357278 0.643444481606585 0.790424185526871 GO:0097110 scaffold protein binding 1/276 70/18639 0.0142857142857143 0.964751552795031 0.648743852800801 0.794916518368576 GO:0019842 vitamin binding 2/276 150/18639 0.0133333333333333 0.900434782608696 0.653931542621413 0.79727691501409 GO:0140299 molecular sensor activity 1/276 71/18639 0.0140845070422535 0.951163502755664 0.653964742273954 0.79727691501409 GO:0004521 RNA endonuclease activity 1/276 73/18639 0.0136986301369863 0.925104228707564 0.664175691512814 0.802716258445858 GO:0003774 cytoskeletal motor activity 2/276 153/18639 0.0130718954248366 0.882779198635976 0.664567075065491 0.802716258445858 GO:0000287 magnesium ion binding 3/276 230/18639 0.0130434782608696 0.88086011342155 0.66506037115039 0.802716258445858 GO:0005085 guanyl-nucleotide exchange factor activity 3/276 230/18639 0.0130434782608696 0.88086011342155 0.66506037115039 0.802716258445858 GO:0003684 damaged DNA binding 1/276 74/18639 0.0135135135135135 0.912602820211516 0.669168016684766 0.805664975312007 GO:0003725 double-stranded RNA binding 1/276 75/18639 0.0133333333333333 0.900434782608696 0.674086391443452 0.807568845194631 GO:0044183 protein folding chaperone 1/276 75/18639 0.0133333333333333 0.900434782608696 0.674086391443452 0.807568845194631 GO:0051536 iron-sulfur cluster binding 1/276 76/18639 0.0131578947368421 0.888586956521739 0.678931907278488 0.811365538574786 GO:0051540 metal cluster binding 1/276 77/18639 0.012987012987013 0.877046866177301 0.683705639627308 0.815057954629599 GO:0004866 endopeptidase inhibitor activity 2/276 161/18639 0.0124223602484472 0.83891439373481 0.691645660836217 0.822138031258089 GO:0016835 carbon-oxygen lyase activity 1/276 79/18639 0.0126582278481013 0.85484314804623 0.693041976763018 0.822138031258089 GO:0000049 tRNA binding 1/276 80/18639 0.0125 0.844157608695652 0.69760665426374 0.824801427119273 GO:0001618 virus receptor activity 1/276 81/18639 0.0123456790123457 0.833735909822866 0.702103694159381 0.824801427119273 GO:0015101 organic cation transmembrane transporter activity 1/276 81/18639 0.0123456790123457 0.833735909822866 0.702103694159381 0.824801427119273 GO:0030971 receptor tyrosine kinase binding 1/276 81/18639 0.0123456790123457 0.833735909822866 0.702103694159381 0.824801427119273 GO:0140272 exogenous protein binding 1/276 82/18639 0.0121951219512195 0.823568398727466 0.706534095086853 0.827996372934714 GO:0030414 peptidase inhibitor activity 2/276 169/18639 0.0118343195266272 0.799202469771032 0.716902742410513 0.838118181948523 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1/276 86/18639 0.0116279069767442 0.785262891809909 0.723608772155472 0.841890975296271 GO:0050660 flavin adenine dinucleotide binding 1/276 86/18639 0.0116279069767442 0.785262891809909 0.723608772155472 0.841890975296271 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 1/276 89/18639 0.0112359550561798 0.758793356130923 0.735761864395233 0.851934790352375 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 1/276 89/18639 0.0112359550561798 0.758793356130923 0.735761864395233 0.851934790352375 GO:0140793 histone H2AXY142 phosphatase activity 1/276 90/18639 0.0111111111111111 0.75036231884058 0.739693385981589 0.854442956599258 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 1/276 91/18639 0.010989010989011 0.742116579073101 0.743566620413045 0.856872010190271 GO:0052689 carboxylic ester hydrolase activity 1/276 92/18639 0.0108695652173913 0.734050094517958 0.74738242873556 0.857846122790311 GO:0003730 mRNA 3'-UTR binding 3/276 262/18639 0.0114503816793893 0.773274145370063 0.74795674342461 0.857846122790311 GO:0051219 phosphoprotein binding 1/276 93/18639 0.010752688172043 0.726157082748948 0.751141659321045 0.859462324140391 GO:0016410 N-acyltransferase activity 1/276 94/18639 0.0106382978723404 0.718432007400555 0.754845148053245 0.861662857683421 GO:0004867 serine-type endopeptidase inhibitor activity 1/276 95/18639 0.0105263157894737 0.710869565217391 0.758493718510905 0.861762816336334 GO:0008276 protein methyltransferase activity 1/276 95/18639 0.0105263157894737 0.710869565217391 0.758493718510905 0.861762816336334 GO:0004896 cytokine receptor activity 1/276 96/18639 0.0104166666666667 0.703464673913043 0.762088182148254 0.861800654578866 GO:0016407 acetyltransferase activity 1/276 96/18639 0.0104166666666667 0.703464673913043 0.762088182148254 0.861800654578866 GO:0004725 protein tyrosine phosphatase activity 1/276 98/18639 0.0102040816326531 0.689108251996451 0.769117975220859 0.865704883736967 GO:0008170 N-methyltransferase activity 1/276 98/18639 0.0102040816326531 0.689108251996451 0.769117975220859 0.865704883736967 GO:0045182 translation regulator activity 4/276 356/18639 0.0112359550561798 0.758793356130923 0.77589813622424 0.871310204019796 GO:0008238 exopeptidase activity 1/276 102/18639 0.00980392156862745 0.662084398976982 0.782562678770594 0.874735188279371 GO:0015171 amino acid transmembrane transporter activity 1/276 102/18639 0.00980392156862745 0.662084398976982 0.782562678770594 0.874735188279371 GO:0004497 monooxygenase activity 1/276 106/18639 0.00943396226415094 0.637100082034454 0.795227142684742 0.886082834789583 GO:0005216 monoatomic ion channel activity 5/276 448/18639 0.0111607142857143 0.753712150621118 0.796376101515431 0.886082834789583 GO:0015291 secondary active transmembrane transporter activity 3/276 287/18639 0.0104529616724739 0.705915770337828 0.800656283085145 0.888801928929381 GO:0008168 methyltransferase activity 2/276 204/18639 0.00980392156862745 0.662084398976982 0.807772838359817 0.894650008618196 GO:1902936 phosphatidylinositol bisphosphate binding 1/276 111/18639 0.00900900900900901 0.60840188014101 0.810029005510173 0.895100544901652 GO:0005516 calmodulin binding 2/276 207/18639 0.00966183574879227 0.652488972904852 0.814212300584731 0.897673698138974 GO:0017124 SH3 domain binding 1/276 115/18639 0.00869565217391304 0.587240075614367 0.821098969785656 0.903208866764222 GO:1990782 protein tyrosine kinase binding 1/276 117/18639 0.00854700854700855 0.577201783723523 0.826390499817935 0.906968258303584 GO:0016741 transferase activity, transferring one-carbon groups 2/276 215/18639 0.00930232558139535 0.628210313447927 0.830453611136254 0.909365492737436 GO:0003697 single-stranded DNA binding 1/276 121/18639 0.00826446280991736 0.558120733021919 0.836510253266537 0.911871537344603 GO:0004540 RNA nuclease activity 1/276 121/18639 0.00826446280991736 0.558120733021919 0.836510253266537 0.911871537344603 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/276 122/18639 0.00819672131147541 0.553545972915182 0.838946972679996 0.91247266242049 GO:0051020 GTPase binding 3/276 315/18639 0.00952380952380952 0.643167701863354 0.848427006893235 0.917582632274332 GO:0004519 endonuclease activity 1/276 127/18639 0.0078740157480315 0.531752824375214 0.850598338523727 0.917582632274332 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 1/276 128/18639 0.0078125 0.527598505434783 0.852825804954553 0.917582632274332 GO:0030695 GTPase regulator activity 5/276 489/18639 0.0102249488752556 0.690517471325687 0.853358486838067 0.917582632274332 GO:0060589 nucleoside-triphosphatase regulator activity 5/276 490/18639 0.0102040816326531 0.689108251996451 0.854565315559202 0.917582632274332 GO:0035591 signaling adaptor activity 1/276 129/18639 0.00775193798449612 0.523508594539939 0.855020180073809 0.917582632274332 GO:0016798 hydrolase activity, acting on glycosyl bonds 1/276 130/18639 0.00769230769230769 0.519481605351171 0.857181953725869 0.917867401777258 GO:0005179 hormone activity 1/276 132/18639 0.00757575757575758 0.511610671936759 0.861409619987083 0.918330960514864 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 1/276 132/18639 0.00757575757575758 0.511610671936759 0.861409619987083 0.918330960514864 GO:0051087 protein-folding chaperone binding 1/276 134/18639 0.00746268656716418 0.503974691758598 0.865512579893601 0.920677117952753 GO:0140789 histone phosphatase activity 1/276 136/18639 0.00735294117647059 0.496563299232737 0.869494499011183 0.922884512108361 GO:0070851 growth factor receptor binding 1/276 139/18639 0.00719424460431655 0.485846105724116 0.875248181194242 0.926958686428913 GO:0015085 calcium ion transmembrane transporter activity 1/276 147/18639 0.00680272108843537 0.459405501330967 0.889385323091241 0.939874446236159 GO:0042578 phosphoric ester hydrolase activity 3/276 363/18639 0.00826446280991736 0.558120733021919 0.907456842878971 0.956882596848413 GO:0015081 sodium ion transmembrane transporter activity 1/276 164/18639 0.00609756097560976 0.411784199363733 0.914347589449924 0.959772461301172 GO:0016791 phosphatase activity 2/276 273/18639 0.00732600732600733 0.494744386048734 0.914655800422372 0.959772461301172 GO:0008017 microtubule binding 2/276 276/18639 0.0072463768115942 0.489366729678639 0.917712362294225 0.959772461301172 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1/276 167/18639 0.00598802395209581 0.404386878417079 0.918129441286039 0.959772461301172 GO:0031267 small GTPase binding 2/276 283/18639 0.00706713780918728 0.477262252266093 0.924449908783675 0.961181013522023 GO:0003823 antigen binding 1/276 174/18639 0.00574712643678161 0.38811844077961 0.926319201944493 0.961181013522023 GO:0015631 tubulin binding 3/276 385/18639 0.00779220779220779 0.526228119706381 0.926828050645323 0.961181013522023 GO:0004721 phosphoprotein phosphatase activity 1/276 175/18639 0.00571428571428571 0.385900621118012 0.927420523377654 0.961181013522023 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 1/276 181/18639 0.00552486187845304 0.373108335335095 0.933692385872173 0.965613493081478 GO:1901981 phosphatidylinositol phosphate binding 1/276 185/18639 0.00540540540540541 0.365041128084606 0.93757057925524 0.967556845116281 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 1/276 229/18639 0.00436681222707424 0.294902221378394 0.967856261331558 0.996686022307392 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 3/276 484/18639 0.00619834710743802 0.418590549766439 0.975930735172608 0.998388824582158 GO:0001216 DNA-binding transcription activator activity 3/276 491/18639 0.00610997963340122 0.412622863720889 0.977815858328351 0.998388824582158 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 1/276 268/18639 0.00373134328358209 0.251987345879299 0.982176907692219 0.998388824582158 GO:0019001 guanyl nucleotide binding 2/276 400/18639 0.005 0.337663043478261 0.982856680521827 0.998388824582158 GO:0032561 guanyl ribonucleotide binding 2/276 400/18639 0.005 0.337663043478261 0.982856680521827 0.998388824582158 GO:0005096 GTPase activator activity 1/276 271/18639 0.003690036900369 0.249197818065137 0.9829682471902 0.998388824582158 GO:0001217 DNA-binding transcription repressor activity 1/276 278/18639 0.00359712230215827 0.242923052862058 0.984681200661759 0.998388824582158 GO:0035091 phosphatidylinositol binding 1/276 284/18639 0.00352112676056338 0.237790875688916 0.986012103616263 0.998388824582158 GO:0003924 GTPase activity 1/276 331/18639 0.00302114803625378 0.204026008143964 0.993143507318233 0.999447090839721 GO:0005525 GTP binding 1/276 378/18639 0.00264550264550265 0.178657694962043 0.996645331480918 0.999447090839721 GO:0140098 catalytic activity, acting on RNA 1/276 387/18639 0.00258397932816537 0.174502864846646 0.997075110649267 0.999447090839721 GO:0016887 ATP hydrolysis activity 1/276 417/18639 0.00239808153477218 0.161948701908039 0.998148906620257 0.999447090839721 GO:0046873 metal ion transmembrane transporter activity 1/276 450/18639 0.00222222222222222 0.150072463768116 0.998881855182283 0.999447090839721 GO:0016755 aminoacyltransferase activity 1/276 496/18639 0.00201612903225806 0.136154453015428 0.999447090839721 0.999447090839721