category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	98/2056	138/9376	3.238481926352	MT-CYB/MT-CO2/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/MT-ND2/MT-ND4/NDUFA4/MT-ND3/COX6C/ATP5F1E/UQCR10/NDUFS5/COX4I1/NDUFB2/COX7B/COX5B/COX8A/UQCRB/ATP5MG/ATP5MC2/NDUFC2/COX6B1/ATP5MC3/UQCRQ/ATP5F1D/NDUFS6/NDUFA2/COX4I2/ATP5MF/COX7C/NDUFB8/NDUFB10/MT-ND5/NDUFV2/NDUFB7/ATP5MC1/NDUFB3/NDUFB11/COX7A2/NDUFB4/ATP6V1F/NDUFC1/NDUFA12/UQCRH/NDUFA13/ATP6V1G1/NDUFA1/ATP5PD/ATP5PO/COX17/NDUFA7/ATP5PF/NDUFA3/NDUFAB1/ATP6V1D/NDUFA4L2/NDUFS4/ATP5F1B/ATP5F1C/NDUFB5/NDUFS8/COX6A1/NDUFA11/UQCR11/ATP6V0A1/NDUFB1/ATP6V1B2/ATP5ME/UQCRC2/COX5A/CYCS/NDUFS7/NDUFB6/ATP6V0B/ATP5F1A/NDUFA6/NDUFS3/ATP6V0D1/NDUFA5/NDUFV1/PPA1/NDUFB9/NDUFV3/ATP6V1C1/NDUFA9/UQCRFS1/ATP6V1A/PPA2/SDHD/NDUFA10/CYC1/COX11/NDUFA8/ATP6V1H/TCIRG1/COX7A1	14.0393114725604
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	147/2056	275/9376	2.4376936681995	MT-CYB/MT-CO2/MT-ATP6/C1QA/CYBA/MT-CO1/MT-CO3/MT-ND1/CYBB/MT-ND2/C1QC/C1QB/MT-ND4/RYR2/EGR1/NDUFA4/MT-ND3/COX6C/ATP5F1E/TUBA1B/UQCR10/NDUFS5/COX4I1/NDUFB2/COX7B/NCF4/COX5B/COX8A/UQCRB/HSPA1A/ATP5MC2/NDUFC2/COX6B1/ATP5MC3/UQCRQ/TUBA1A/ATP5F1D/NDUFS6/NDUFA2/COX4I2/COX7C/SLC25A6/NDUFB8/SLC25A5/NDUFB10/MT-ND5/NDUFV2/ITPR2/NDUFB7/ATP5MC1/CREB1/NDUFB3/PSMA7/NDUFB11/COX7A2/NDUFB4/NDUFC1/PSMA1/PSMB3/NDUFA12/UQCRH/NDUFA13/NDUFA1/ATP5PD/ATP5PO/PSMB4/PPP3R1/NDUFA7/ATP5PF/PSMA4/NDUFA3/NDUFAB1/PRKACB/NCF1/NDUFA4L2/NDUFS4/ATP5F1B/ATP5F1C/NDUFB5/NDUFS8/COX6A1/NDUFA11/PSMB2/PSMC4/RAC2/UQCR11/PSMB6/NDUFB1/PSMA2/PIK3CD/VDAC3/KIF5B/BAX/PSMA3/UQCRC2/COX5A/CYCS/NDUFS7/NDUFB6/PSMB1/ATP5F1A/PSMA5/PRNP/NDUFA6/NDUFS3/EIF2S1/CCL5/NCF2/LAMC1/NDUFA5/VDAC2/CSNK2A1/PIK3R3/NDUFV1/IL1B/PRKACA/PPP3CB/PSMD4/PSMC2/TUBB2A/NDUFB9/NDUFV3/PSMB7/NDUFA9/UQCRFS1/PSMD11/PSMD13/ITPR1/TNF/SDHD/NDUFA10/CYC1/RYR1/NDUFA8/GRIN2C/APAF1/NCAM2/PSMD6/NOTCH1/PSMD9/CREB3L1/MAPK13/COX7A1/MAPK10/HSPA6/DDIT3/C9	12.8241858311757
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	120/2056	205/9376	2.66945050773465	CD36/MT-CYB/MT-CO2/MT-ATP6/CYBA/MT-CO1/COL3A1/MT-CO3/MT-ND1/CYBB/MT-ND2/COL1A1/COL1A2/MMP2/MT-ND4/RYR2/NDUFA4/MT-ND3/COX6C/ATP5F1E/UQCR10/NDUFS5/COX4I1/PRKCB/NDUFB2/COX7B/NCF4/PRKCA/COX5B/COX8A/PLCB1/UQCRB/ATP5MC2/NDUFC2/COX6B1/NFKB1/ATP5MC3/UQCRQ/ATP5F1D/NDUFS6/NDUFA2/COX4I2/COX7C/SLC25A6/NDUFB8/SLC25A5/NDUFB10/MT-ND5/NDUFV2/NDUFB7/ATP5MC1/NDUFB3/NDUFB11/COX7A2/NDUFB4/NDUFC1/NDUFA12/UQCRH/NDUFA13/NDUFA1/ATP5PD/ATP5PO/PPP1CB/NDUFA7/ATP5PF/NDUFA3/NDUFAB1/NCF1/NDUFA4L2/NDUFS4/ATP5F1B/ATP5F1C/NDUFB5/NDUFS8/COX6A1/NDUFA11/CAMK2D/TGFBR1/RAC2/UQCR11/NDUFB1/PIK3CD/VDAC3/TBC1D4/UQCRC2/COX5A/NDUFS7/NDUFB6/PARP1/ATP5F1A/MPC1/NDUFA6/NDUFS3/PPP1CA/NCF2/NDUFA5/VDAC2/PIK3R3/NDUFV1/PLCB2/NDUFB9/NDUFV3/PDHB/NDUFA9/UQCRFS1/MPC2/SDHD/NDUFA10/CYC1/PPP1CC/NDUFA8/AKT1/AGTR1/AKT2/PDK2/MAPK13/COX7A1/MAPK10/IRS1/TGFB3	12.8080727345824
Genetic Information Processing	Translation	hsa03010	Ribosome	125/2056	222/9376	2.56774284011638	RPS23/RPS11/RPS18/RPL28/RPL32/RPS27A/RPS4X/RPL10/RPL26/RPL30/RPS14/RPL39/RPS9/RPL13A/FAU/RPS15A/RPLP1/UBA52/RPS12/RPL13/RPL14/RPL15/RPL11/RPL19/RPS2/RPS15/RPS19/RPL27A/RPL23/RPL23A/RPL29/RPS7/RPL41/RPL7A/RPL35/RPS25/RPS8/RPL17/RPL24/RPL18/RPL21/RPL36AL/RPLP2/RPL34/RPL22/RPL12/RPS24/RPL36A/RPL35A/RPL3/RACK1/RPL10A/RPS17/RPS16/MRPS6/RPL7/RPL18A/RPL9/RPL36/RPS5/RPL31/RPL27/RPLP0/RPL38/MRPS21/RPL37/RPS6/RPL5/MRPL14/RPL6/RPS20/RPS13/MRPL51/RPL22L1/RPL26L1/RPL8/RSL24D1/MRPL16/MRPL40/MRPL41/MRPL54/MRPL55/RPS27L/MRPL20/RPSA/MRPS16/MRPL27/MRPL36/MRPS23/MRPL11/MRPL21/RPS21/RPL37A/MRPS18C/MRPL52/MRPS25/MRPL19/MRPL42/MRPL47/MRPS34/MRPL18/MRPS27/MRPL13/MRPL22/MRPL4/MRPL32/MRPS17/MRPS28/MRPL15/MRPL2/MRPS12/MRPL43/MRPL35/MRPS7/MRPS26/MRPS33/MRPS14/MRPL50/MRPL12/MRPL9/MRPS18A/MRPL44/MRPS9/MRPL24/MRPS22	12.5281663699399
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	140/2056	268/9376	2.38225216330797	MT-CYB/MT-CO2/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/MT-ND2/RPS27A/UBA52/MT-ND4/NDUFA4/CALM2/UBB/MT-ND3/COX6C/ATP5F1E/TUBA1B/UQCR10/NDUFS5/COX4I1/NDUFB2/COX7B/GNAI2/COX5B/COX8A/UQCRB/ATP5MC2/NDUFC2/COX6B1/ATP5MC3/UQCRQ/TUBA1A/ATP5F1D/NDUFS6/NDUFA2/COX4I2/COX7C/SLC25A6/NDUFB8/SLC25A5/NDUFB10/MT-ND5/NDUFV2/ITPR2/NDUFB7/ATP5MC1/CALM3/NDUFB3/PSMA7/NDUFB11/COX7A2/NDUFB4/NDUFC1/PSMA1/PSMB3/NDUFA12/UQCRH/NDUFA13/NDUFA1/ATP5PD/ATP5PO/PSMB4/NDUFA7/ATP5PF/PSMA4/NDUFA3/NDUFAB1/PRKACB/PARK7/NDUFA4L2/NDUFS4/ATP5F1B/ATP5F1C/NDUFB5/NDUFS8/COX6A1/NDUFA11/PSMB2/CAMK2D/PSMC4/PRKN/UQCR11/PSMB6/NDUFB1/PSMA2/VDAC3/KIF5B/MAP3K5/BAX/GNAI3/PSMA3/UQCRC2/COX5A/CYCS/NDUFS7/NDUFB6/PSMB1/ATP5F1A/PSMA5/NDUFA6/NDUFS3/EIF2S1/CALML4/NFE2L2/NDUFA5/VDAC2/NDUFV1/PRKACA/TP53/PSMD4/PSMC2/TUBB2A/NDUFB9/NDUFV3/PSMB7/NDUFA9/UQCRFS1/PSMD11/PSMD13/ITPR1/UBE2J1/SDHD/NDUFA10/CYC1/TXN2/NDUFA8/BCL2L1/SNCA/DAXX/APAF1/PSMD6/PSMD9/LRRK2/HTRA2/COX7A1/MAPK10/KEAP1/TRAP1/DDIT3/PLCG1	12.1670366760761
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	121/2056	227/9376	2.43082671969009	MT-CYB/MT-CO2/MT-ATP6/CYBA/MT-CO1/MT-CO3/MT-ND1/MT-ND2/HGF/MT-ND4/NDUFA4/MT-ND3/COX6C/JUN/ATP5F1E/UQCR10/NDUFS5/COX4I1/PLD1/PTPRJ/NDUFB2/COX7B/COX5B/COX8A/UQCRB/ATP5MC2/NDUFC2/COX6B1/HIF1A/NFKB1/ATP5MC3/UQCRQ/ATP5F1D/NDUFS6/NDUFA2/COX4I2/COX7C/SLC25A6/NDUFB8/SLC25A5/NDUFB10/MT-ND5/NDUFV2/NDUFB7/ATP5MC1/NDUFB3/NDUFB11/COX7A2/NDUFB4/NDUFC1/NDUFA12/UQCRH/NDUFA13/NDUFA1/ATP5PD/ATP5PO/AKR1A1/NDUFA7/ATP5PF/NDUFA3/NDUFAB1/NCF1/NDUFA4L2/NDUFS4/ATP5F1B/ATP5F1C/NDUFB5/NDUFS8/COX6A1/MGST2/NDUFA11/GSTO1/UQCR11/MAP2K2/NDUFB1/PIK3CD/VDAC3/GRB2/SOS1/MAP3K5/UQCRC2/BRAF/COX5A/NDUFS7/NDUFB6/ATP5F1A/NDUFA6/PTPN1/NDUFS3/NCF2/CAT/NFE2L2/NDUFA5/VDAC2/PIK3R3/NDUFV1/ABL1/NDUFB9/NDUFV3/NDUFA9/UQCRFS1/EPHX1/SLC26A2/SDHD/NDUFA10/CYC1/AHR/ABL2/NDUFA8/AKT1/KRAS/MAP3K14/HRAS/GSTA4/AKT2/PRKD2/MAPK13/COX7A1/MAPK10/KEAP1/IKBKB	11.5652442533629
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	147/2056	308/9376	2.17651220374956	MT-CYB/MT-CO2/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/MT-ND2/MT-ND4/NDUFA4/MT-ND3/COX6C/ATP5F1E/TUBA1B/UQCR10/NDUFS5/COX4I1/CLTC/NDUFB2/COX7B/COX5B/COX8A/PLCB1/UQCRB/ATP5MC2/NDUFC2/COX6B1/ATP5MC3/UQCRQ/TUBA1A/ATP5F1D/NDUFS6/NDUFA2/COX4I2/COX7C/SLC25A6/NDUFB8/POLR2L/SLC25A5/NDUFB10/MT-ND5/NDUFV2/CLTA/NDUFB7/ATP5MC1/CREB1/NDUFB3/PSMA7/NDUFB11/COX7A2/NDUFB4/NDUFC1/PSMA1/PSMB3/NDUFA12/UQCRH/NDUFA13/AP2S1/NDUFA1/ATP5PD/ATP5PO/PSMB4/NDUFA7/ATP5PF/PSMA4/NDUFA3/NDUFAB1/NDUFA4L2/NDUFS4/ATP5F1B/ATP5F1C/NDUFB5/NDUFS8/COX6A1/NDUFA11/POLR2K/PSMB2/PSMC4/UQCR11/PSMB6/POLR2J/NDUFB1/PSMA2/VDAC3/DCTN4/KIF5B/MAP3K5/BAX/PSMA3/UQCRC2/POLR2I/GNAQ/COX5A/POLR2A/CYCS/NDUFS7/NDUFB6/PSMB1/AP2M1/ATP5F1A/POLR2G/PSMA5/NDUFA6/POLR2E/DCTN3/NDUFS3/GRIA4/POLR2J3/NDUFA5/CREBBP/VDAC2/HDAC2/NDUFV1/TP53/PSMD4/PSMC2/PLCB2/TUBB2A/ACTR1A/DCTN6/NDUFB9/NDUFV3/PSMB7/NDUFA9/UQCRFS1/DCTN2/PSMD11/PSMD13/ITPR1/DNAH8/SDHD/NDUFA10/CYC1/ULK2/NDUFA8/BDNF/APAF1/TFAM/PSMD6/POLR2B/PSMD9/TBPL1/PIK3R4/CREB3L1/DLG4/COX7A1/MAPK10/DNALI1	11.1264774414612
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	122/2056	238/9376	2.33763855736847	F13A1/CCL2/RPS23/C1QA/CYBB/NRP1/CFD/RPS11/RPS18/C1QC/RPL28/RPL32/RPS27A/RPS4X/RPL10/RPL26/RPL30/RPS14/RPL39/RPS9/RPL13A/FAU/RPS15A/C1QB/RPLP1/UBA52/RPS12/RPL13/RPL14/RPL15/RPL11/RPL19/RPS2/RPS15/RPS19/RPL27A/RPL23/RPL23A/JUN/RPL29/RPS7/RPL41/RPL7A/RPL35/CXCL8/RPS25/RPS8/RPL17/RPL24/PRKCB/FCGR2A/RPL18/RPL21/RPL36AL/C3AR1/RPLP2/RPL34/RPL22/PRKCA/RPL12/RPS24/RPL36A/NFKB1/RPL35A/RPL3/RPL10A/RPS17/RPS16/RPL7/C1R/RPL18A/SYK/C2/RPL9/RPL36/TLR4/RPS5/RPL31/RPL27/RPLP0/RPL38/NLRP3/RPL37/RPS6/MMP1/RPL5/TNFRSF1A/RPL6/RPS20/RPS13/CASP1/RPL22L1/RPL26L1/PIK3CD/RPL8/RSL24D1/STAT3/RPS27L/RPSA/TAB2/TLR7/RPS21/RPL37A/PIK3R3/IL1B/TLR2/TNF/MAP3K7/IL6R/CGAS/AGTR1/HBEGF/TLR8/IRAK4/NFKBIB/IRF9/MAPK13/MAPK10/C1S/PLCG1/IKBKB/C9	11.0775401629722
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	89/2056	157/9376	2.5851446132494	MT-CYB/MT-CO2/MT-CO1/MT-CO3/NDUFA4/COX6C/JUN/UQCR10/NDUFS5/COX4I1/CXCL8/NDUFB2/COX7B/COX5B/COX8A/UQCRB/NDUFC2/COX6B1/NFKB1/UQCRQ/NDUFS6/NDUFA2/COX4I2/COX7C/NDUFB8/NDUFB10/NDUFV2/NDUFB7/NDUFB3/NDUFB11/COX7A2/NDUFB4/NDUFC1/NDUFA12/UQCRH/NDUFA13/NDUFA1/BID/NDUFA7/NDUFA3/NDUFAB1/TNFRSF1A/NDUFA4L2/NDUFS4/NDUFB5/NDUFS8/COX6A1/NDUFA11/UQCR11/NDUFB1/SOCS3/PIK3CD/MAP3K5/BAX/UQCRC2/COX5A/CYCS/NDUFS7/NDUFB6/NDUFA6/NDUFS3/EIF2S1/NDUFA5/PIK3R3/MLXIP/NDUFV1/IL1B/NDUFB9/NDUFV3/NDUFA9/UQCRFS1/TNF/ADIPOR1/SDHD/NDUFA10/CYC1/NDUFA8/IL6R/AKT1/AKT2/LEPR/MLX/MAPK13/COX7A1/MAPK10/IRS1/DDIT3/MAP3K11/IKBKB	10.6149624140414
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	117/2056	235/9376	2.27045285205729	MT-CYB/MT-CO2/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/MT-ND2/PRKG1/MT-ND4/NDUFA4/MT-ND3/COX6C/ATP5F1E/UQCR10/NDUFS5/COX4I1/NDUFB2/COX7B/COX5B/COX8A/UQCRB/ATP5MG/ATP5MC2/NDUFC2/COX6B1/ATP5MC3/UQCRQ/ATP5F1D/NDUFS6/NDUFA2/COX4I2/ATP5MF/COX7C/NDUFB8/NDUFB10/MT-ND5/NDUFV2/NDUFB7/ATP5MC1/CREB1/NDUFB3/NDUFB11/COX7A2/NDUFB4/NDUFC1/NDUFA12/UQCRH/NDUFA13/NDUFA1/RPS6/ATP5PD/ATP5PO/COX17/NDUFA7/ATP5PF/NDUFA3/NDUFAB1/PRKACB/NDUFAF8/NDUFA4L2/NDUFS4/ATP5F1B/ATP5F1C/NDUFAF3/NDUFB5/NDUFS8/COX6A1/NDUFA11/UQCR11/NDUFB1/COX14/ATP5ME/GRB2/SOS1/COX16/MAP3K5/UQCRC2/COX5A/NDUFS7/COA1/NDUFB6/COA4/ATP5F1A/RPS6KA3/COA3/NDUFA6/NDUFS3/ARID1A/NDUFA5/SMARCA2/NDUFV1/PRKACA/COX20/NDUFB9/NDUFV3/ACTG1/NDUFA9/UQCRFS1/SDHD/NDUFA10/CYC1/COX11/NDUFA8/KRAS/ACSL5/HRAS/NDUFAF6/COA5/RPS6KB2/ACTL6A/COA6/CREB3L1/MAPK13/COX7A1/ADCY4/NDUFAF4/NDUFAF5	10.4529117065898
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	158/2056	368/9376	1.95795973608526	MT-CYB/MT-CO2/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/MT-ND2/MT-ND4/NDUFA4/MT-ND3/COX6C/ATP5F1E/TUBA1B/UQCR10/NDUFS5/COX4I1/NDUFB2/COX7B/COX5B/COX8A/UQCRB/ATP5MC2/NDUFC2/COX6B1/ATP5MC3/UQCRQ/TUBA1A/ATP5F1D/NDUFS6/NDUFA2/COX4I2/COX7C/NDUFB8/NDUFB10/MT-ND5/NDUFV2/NDUFB7/ATP5MC1/TNFRSF1B/NDUFB3/PSMA7/NDUFB11/COX7A2/TANK/NDUFB4/NDUFC1/PSMA1/PSMB3/NDUFA12/UQCRH/PFN1/NDUFA13/NDUFA1/BID/ATP5PD/ATP5PO/PSMB4/SRSF3/PPP3R1/NDUFA7/ATP5PF/PSMA4/NDUFA3/NDUFAB1/TNFRSF1A/CHCHD10/NDUFA4L2/NDUFS4/ATP5F1B/ATP5F1C/NDUFB5/NDUFS8/COX6A1/CASP1/NDUFA11/PSMB2/PSMC4/PRKN/UQCR11/PSMB6/NDUFB1/PSMA2/DCTN4/HNRNPA3/KIF5B/MAP3K5/BAX/PSMA3/UQCRC2/COX5A/CYCS/NDUFS7/NUP54/NDUFB6/PSMB1/SPG11/ATP5F1A/NUP214/C9orf72/PSMA5/NDUFA6/RANBP2/DCTN3/NDUFS3/EIF2S1/CAT/NDUFA5/NDUFV1/TP53/PPP3CB/PSMD4/PSMC2/TUBB2A/ACTR1A/DCTN6/NDUFB9/NDUFV3/PSMB7/POM121C/ACTG1/NDUFA9/UQCRFS1/DCTN2/PSMD11/PSMD13/SEC13/TNF/DNAH8/CCS/SDHD/NDUFA10/CYC1/NUP133/FIG4/ULK2/NUP160/NDUFA8/RAE1/GRIN2C/BCL2L1/DAXX/APAF1/UBQLN4/PSMD6/SEH1L/PSMD9/GLE1/PFN2/PIK3R4/ALS2/NUP37/MAPK13/COX7A1/NUP88/DDIT3/DNALI1/SMCR8/MAP2K6	9.935703642351
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	190/2056	480/9376	1.80512321660182	MT-CYB/MT-CO2/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/CYBB/MT-ND2/WNT2/RPS27A/UBA52/MT-ND4/RYR2/NDUFA4/CALM2/UBB/MT-ND3/COX6C/ATP5F1E/TUBA1B/UQCR10/NDUFS5/COX4I1/PRKCB/NDUFB2/COX7B/PRKCA/COX5B/COX8A/PLCB1/UQCRB/ATP5MC2/NDUFC2/COX6B1/NFKB1/ATP5MC3/UQCRQ/TUBA1A/ATP5F1D/NDUFS6/NDUFA2/COX4I2/COX7C/SLC25A6/NDUFB8/SLC25A5/NDUFB10/MT-ND5/NDUFV2/ITPR2/NDUFB7/ATP5MC1/TNFRSF1B/ATXN1/CALM3/NDUFB3/PSMA7/NDUFB11/COX7A2/TANK/NDUFB4/NDUFC1/PSMA1/PSMB3/NDUFA12/UQCRH/NDUFA13/NDUFA1/BID/ATP5PD/ATP5PO/PSMB4/PPP3R1/NDUFA7/ATP5PF/PSMA4/NDUFA3/NDUFAB1/TNFRSF1A/PARK7/NDUFA4L2/NDUFS4/ATP5F1B/ATP5F1C/NDUFB5/NDUFS8/COX6A1/LRP6/NDUFA11/PSMB2/CAMK2D/PSMC4/PRKN/UQCR11/PSMB6/MAP2K2/NDUFB1/PSMA2/VDAC3/DCTN4/KIF5B/MAP3K5/BAX/PSMA3/UQCRC2/BRAF/GNAQ/COX5A/CYCS/NDUFS7/NDUFB6/PSMB1/SPG11/ATP5F1A/C9orf72/PSMA5/PRNP/NDUFA6/DCTN3/NDUFS3/EIF2S1/GRIA4/CALML4/CAT/NDUFA5/APC/VDAC2/CSNK2A1/NDUFV1/IL1B/PPP3CB/PSMD4/PSMC2/PLCB2/TUBB2A/ACTR1A/DCTN6/NDUFB9/HSD17B10/NDUFV3/PSMB7/NDUFA9/UQCRFS1/DCTN2/PSMD11/PSMD13/CSF1/ITPR1/UBE2J1/TNF/DNAH8/CCS/SDHD/WNT2B/NDUFA10/CYC1/FIG4/ULK2/RYR1/NDUFA8/KRAS/GRIN2C/HRAS/BCL2L1/SNCA/BDNF/DAXX/APAF1/CAPN1/PSMD6/FZD2/PSMD9/PIK3R4/DKK2/ALS2/LRRK2/HTRA2/DLG4/MAPK13/COX7A1/MAPK10/TRAP1/DDIT3/PLCG1/DNALI1/FZD5/SMCR8/FZD7/DVL2/MAP2K6	9.59681746798971
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	161/2056	388/9376	1.89229411528742	MT-CYB/MT-CO2/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/CYBB/MT-ND2/WNT2/MT-ND4/NDUFA4/CALM2/MT-ND3/COX6C/ATP5F1E/TUBA1B/UQCR10/NDUFS5/COX4I1/APOE/NDUFB2/COX7B/COX5B/COX8A/PLCB1/UQCRB/ATP5MC2/NDUFC2/COX6B1/NFKB1/ATP5MC3/UQCRQ/TUBA1A/ATP5F1D/NDUFS6/NDUFA2/COX4I2/COX7C/SLC25A6/NDUFB8/SLC25A5/NDUFB10/MT-ND5/NDUFV2/ITPR2/NDUFB7/ATP5MC1/CALM3/NDUFB3/PSMA7/NDUFB11/COX7A2/NDUFB4/NDUFC1/PSMA1/PSMB3/NDUFA12/UQCRH/NDUFA13/NDUFA1/BID/ATP5PD/ATP5PO/PSMB4/PPP3R1/NDUFA7/ATP5PF/PSMA4/LRP1/NDUFA3/NDUFAB1/TNFRSF1A/NDUFA4L2/NDUFS4/ATP5F1B/ATP5F1C/NDUFB5/NDUFS8/COX6A1/LRP6/NDUFA11/PSMB2/PSMC4/UQCR11/PSMB6/MAP2K2/NDUFB1/PSMA2/PIK3CD/VDAC3/KIF5B/MAP3K5/PSMA3/UQCRC2/BRAF/GNAQ/COX5A/CYCS/NDUFS7/NDUFB6/PSMB1/ATP5F1A/PSMA5/NDUFA6/NDUFS3/EIF2S1/CALML4/NDUFA5/PSENEN/APC/VDAC2/CSNK2A1/PIK3R3/NDUFV1/IL1B/PPP3CB/PSMD4/PSMC2/PLCB2/TUBB2A/NDUFB9/HSD17B10/NDUFV3/PSMB7/NDUFA9/UQCRFS1/PSMD11/PSMD13/CSF1/ITPR1/TNF/SDHD/WNT2B/NDUFA10/CYC1/ULK2/NDUFA8/AKT1/KRAS/GRIN2C/HRAS/SNCA/APAF1/CAPN1/APH1B/AKT2/PSMD6/FZD2/NAE1/PSMD9/BACE1/PIK3R4/DKK2/COX7A1/MAPK10/IRS1/DDIT3/FZD5/IKBKB/FZD7/DVL2	9.51336177744771
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	68/2056	149/9376	2.08121588802131	MT-ND1/MT-ND2/GNG2/MT-ND4/NDUFA4/MT-ND3/GNG11/NDUFS5/PRKCB/NDUFB2/GNAI2/PRKCA/PLCB1/NDUFC2/GNGT1/NDUFS6/NDUFA2/GNG5/NDUFB8/NDUFB10/MT-ND5/NDUFV2/ITPR2/NDUFB7/GNG10/NDUFB3/NDUFB11/NDUFB4/NDUFC1/NDUFA12/NDUFA13/NDUFA1/NDUFA7/GNB4/NDUFA3/NDUFAB1/PRKACB/NDUFA4L2/NDUFS4/NDUFB5/NDUFS8/NDUFA11/NDUFB1/GNAI3/GNB1/GNAQ/KCNJ5/NDUFS7/NDUFB6/GNB2/NDUFA6/NDUFS3/GRIA4/NDUFA5/NDUFV1/PRKACA/PLCB2/NDUFB9/NDUFV3/NDUFA9/ITPR1/NDUFA10/NDUFA8/GABRA3/GNG7/MAPK13/MAPK10/ADCY4	7.05045176228629
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	88/2056	224/9376	1.79155086158977	NRP1/CCND2/HLA-C/EGR1/JUN/HLA-A/SPI1/HLA-DRA/CCND1/NFKB1/RB1/CD4/SLC25A6/SLC25A5/HLA-DPA1/CREB1/ICAM1/ITGB2/ANAPC11/NFATC2/HLA-DQA2/PPP3R1/EGR2/MAP3K1/TNFRSF1A/PRKACB/ATM/TGFBR1/MAP2K2/HLA-DMA/PIK3CD/VDAC3/RAN/BAX/JAK3/RANBP1/CDC27/NFATC3/TSPO/ATR/XPO1/MAP3K3/HLA-DMB/TLN1/CREBBP/VDAC2/PIK3R3/PRKACA/TP53/PPP3CB/ETS1/RELB/CDC16/TNF/ITGAL/BUB3/IL2RA/CDK4/AKT1/KRAS/MAP3K14/HRAS/KAT2B/ANAPC15/FDPS/BCL2L1/ANAPC10/AKT2/HLA-F/PTTG1/CDKN2A/ANAPC7/TRRAP/MAD1L1/E2F3/TBPL1/ELK4/CHEK2/STAT5A/TCF3/CREB3L1/MAPK10/CCNB2/TGFB3/MSX1/IKBKB/ADCY4/IL2RG	6.35457459609308
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	94/2056	250/9376	1.71467704280156	CTSC/LGMN/LAPTM5/CLTC/AP1S2/BLOC1S1/ASAH1/LAMTOR4/VPS29/CLTA/CTSS/MANBA/CD68/ATP6V1F/LAMTOR2/LAMTOR5/SUMF1/ATP6V1G1/AP2S1/AP1B1/ARSB/ATP6V1D/WDR7/MAN2B1/DMXL2/ATP6V0A1/ATP6V1B2/LAMTOR1/VPS13C/M6PR/VAMP8/NEU1/AP2M1/ATP6V0B/HYAL2/SPG11/PLA2G15/OSBPL6/NPC1/BORCS5/TLR7/OSBPL3/ATP6V0D1/LIPA/BORCS7/LAMTOR3/BLOC1S2/DTNBP1/MITF/PIKFYVE/CTBS/NCOA7/ATP6V1C1/RRAGA/ATP6V1A/GPR155/LAPTM4B/VPS35/GLA/DEPTOR/CLCN7/CLN6/SLC36A1/FIG4/TPCN1/GGA1/ATP6V1H/MCOLN2/ACP2/TCIRG1/GALC/SLC36A4/ABCA2/TMEM175/ARL8A/TLR8/CTSO/RRAGB/VPS16/VPS11/BLOC1S5/TFEB/AP5M1/VPS33A/AP4S1/CLN8/TFE3/BORCS8/CTSK/AP5Z1/MFSD8/SLC15A4/AP4M1/OSBPL1A	6.06989609235741
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	41/2056	85/9376	2.19967956054017	ENPP1/APRT/NME2/ADA2/NME3/GUK1/TYMP/IMPDH2/NT5C/DUT/NME1/CTPS2/RRM1/AK1/ITPA/DCK/DGUOK/NME4/AK6/LACC1/DTYMK/TK2/NUDT16/ENTPD8/HDDC2/HPRT1/NME6/GMPS/PNP/NT5C3A/IMPDH1/TYMS/NTPCR/AK3/AK9/DCTPP1/GMPR/AMPD2/RRM2B/UCK1/GMPR2	5.88823514773513
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	35/2056	73/9376	2.18645061563883	HGF/CDK6/PRKCB/PRKCA/CCND1/RB1/EML4/RARB/MAP2K2/PIK3CD/FHIT/STAT3/GRB2/SOS1/KIF5B/BAX/JAK3/BRAF/STK4/PIK3R3/TP53/POLK/CDK4/AKT1/KRAS/HRAS/RASSF5/RASSF1/AKT2/CDKN2A/DDB2/E2F3/STAT5A/PLCG1/TGFA	5.39313433974449
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	42/2056	95/9376	2.01613762031538	CCL3/CCL2/CCL3L1/JUN/CXCL8/HLA-DRA/CD86/HLA-DPA1/TNFSF13B/CD28/TLR4/ATP6V1F/ICAM1/ITGB2/ATP6V1G1/MMP1/HLA-DQA2/ANGPT1/ATP6V1D/ATP6V0A1/ATP6V1B2/HLA-DMA/TNFRSF11A/ATP6V0B/ATP6V0D1/CCL5/HLA-DMB/IL1B/TLR2/LTB/ATP6V1C1/CSF1/TNF/ATP6V1A/ITGAL/TEK/CXCL12/ATP6V1H/TCIRG1/CXCL1/CTSK/TGFB3	5.27543892684694
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	87/2056	248/9376	1.5997866198067	CD14/LY96/PTPRC/JUN/TUBA1B/CXCL8/DYNLL1/PYCARD/ARPC3/S100A10/NFKB1/TUBA1A/CYTH4/ARPC5/TLR4/ELMO1/NCKAP1L/PFN1/NLRP3/RAB5C/RHOG/TNFRSF1A/CASP1/BRK1/MAP2K2/MYL12A/PIK3CD/DCTN4/DYNLRB1/KIF5B/PIK3CG/BAX/ACTR2/M6PR/CYCS/TNFRSF10B/ARPC4/KPNA4/TAB2/DCTN3/CYFIP1/PKN1/IL1B/LEF1/TLR2/RIPK1/TUBB2A/ACTR1A/DCTN6/ACTG1/DCTN2/RIPK2/TNF/RAB9A/PLEKHM2/TCF7/EXOC7/TXN2/MAP3K7/PIK3C2B/AKT1/STX10/HRAS/NAIP/AKT2/CYTH2/CASP4/TLR5/ARL8A/CSE1L/PFN2/IRAK4/DYNC2LI1/VPS16/VPS11/TAB3/VPS33A/BIRC2/MAPK13/MAPK10/DYNC2H1/TLR6/NOD1/IKBKB/FYCO1/MAP2K6/TNFRSF10A	5.07313536609561
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	81/2056	227/9376	1.6272476388008	CCL3/CCL2/CCL4/CCL4L2/GNG2/CCL3L1/CDK6/HLA-C/CALM2/HLA-A/GNG11/CXCL8/PRKCB/GNAI2/PRKCA/PLCB1/CCND1/NFKB1/GNGT1/RB1/GNG5/ITPR2/GNG10/CALM3/CREB1/BID/NFATC2/PPP3R1/GNB4/TNFRSF1A/PRKACB/IL10RA/GNA13/RAC2/MAP2K2/PIK3CD/EIF4EBP1/STAT3/GRB2/SOS1/BAX/GNAI3/GNB1/GNAQ/ROCK1/CYCS/NFATC3/CCR1/PTGER4/GNB2/IL10RB/CCL5/CALML4/PIK3R3/IL1B/PRKACA/TP53/PPP3CB/PLCB2/RIPK1/ITPR1/TNF/CXCL12/CDK4/IL6R/AKT1/KRAS/HRAS/CGAS/RPS6KB2/AKT2/HLA-F/CDKN2A/GNG7/E2F3/CREB3L1/MAPK13/ARHGEF1/IKBKB/ADCY4/MAP2K6	5.06998649818874
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	52/2056	128/9376	1.85262645914397	ENPP1/PDE4D/PDE4B/GUCY1A2/APRT/NME2/GUCY1A1/PDE3A/ADA2/NME3/GUK1/FHIT/PDE3B/IMPDH2/NT5C/NME1/RRM1/AK1/ITPA/DCK/DGUOK/NME4/GUCY1B1/AK6/LACC1/NUDT16/ENTPD8/HDDC2/HPRT1/NME6/GMPS/PNP/IMPDH1/NUDT9/PDE7A/NTPCR/PDE6D/PRPS1/HDDC3/AK3/AK9/PDE1C/PDE9A/GART/PAICS/GMPR/AMPD2/PRPS2/RRM2B/GMPR2/ADCY4/PDE5A	5.14732431964276
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	44/2056	105/9376	1.91098758569576	CD14/CCL4/CCL4L2/LY96/EDA/VCAM1/CXCL8/PRKCB/LYN/NFKB1/SYK/TNFSF13B/TLR4/ICAM1/PLAU/TNFRSF1A/BCL2A1/ATM/TNFRSF11A/PARP1/UBE2I/TAB2/CYLD/CSNK2A1/IL1B/RIPK1/RELB/LTB/MALT1/TNF/CCL13/CXCL12/MAP3K7/MAP3K14/BCL2L1/BTK/TRIM25/CXCL1/IRAK4/TAB3/BIRC2/BLNK/PLCG1/IKBKB	4.97491277389625
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	55/2056	142/9376	1.76631775086316	CYBA/TYROBP/FCGR3A/JUN/SPI1/JUNB/LCP2/FCGR1A/FCGR2A/NCF4/NFKB1/LILRB5/ITPR2/SYK/CREB1/NFATC2/PPP3R1/CSF1R/TNFRSF1A/NCF1/TGFBR1/SOCS3/PIK3CD/SIRPA/GRB2/GAB2/TNFRSF11A/TAB2/CYLD/TEC1/NCF2/PIK3R3/MITF/IL1B/PPP3CB/RELB/CSF1/ITPR1/TNF/MAP3K7/AKT1/MAP3K14/TMEM64/LILRB1/AKT2/BTK/IRF9/MAPK13/LILRB3/MAPK10/BLNK/CTSK/FCGR2B/IKBKB/MAP2K6	4.87640508556013
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	76/2056	216/9376	1.60455397031273	CD14/CCL3/CD36/CCL2/CYBA/CYBB/CCL3L1/LY96/CALM2/JUN/VCAM1/CXCL8/LYN/PYCARD/NCF4/PRKCA/PLCB1/HSPA1A/NFKB1/POU2F2/CALM3/TANK/TLR4/ICAM1/NLRP3/BID/NFATC2/MMP1/PPP3R1/VAV1/TNFRSF1A/NCF1/CASP1/CAMK2D/PIK3CD/STAT3/MIB1/MAP3K5/BAX/CYCS/TNFRSF10B/NFATC3/TAB2/EIF2S1/CCL5/NCF2/CALML4/NFE2L2/PIK3R3/IL1B/TP53/TLR2/PPP3CB/PLCB2/ITPR1/TNF/MAP3K7/AKT1/KRAS/HRAS/BCL2L1/APAF1/AKT2/VLDLR/CXCL1/IRAK4/MAPK13/MAPK10/HSPA6/ARHGEF1/DDIT3/PLCG1/TLR6/IKBKB/MAP2K6/TNFRSF10A	4.76382576820338
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	70/2056	196/9376	1.62868260144525	GNG2/RPS27A/UBA52/CDK6/HLA-C/CALM2/UBB/JUN/HLA-A/GNG11/CXCL8/LYN/CD86/CCND1/HIF1A/NFKB1/GNGT1/RB1/GNG5/ITPR2/GNG10/SYK/CALM3/CREB1/ICAM1/HCK/BID/NFATC2/PPP3R1/GNB4/TNFRSF1A/PREX1/CD200R1/MAP2K2/PIK3CD/STAT3/PIK3CG/BAX/GNB1/CYCS/NFATC3/CCR1/PIK3R5/GNB2/CALML4/CLEC2B/CREBBP/PIK3R3/TP53/LEF1/PPP3CB/ITPR1/TCF7/CDK4/AKT1/KRAS/HRAS/AKT2/HLA-F/GNG7/E2F3/CXCL1/IRF9/MAPK13/MAPK10/PLCG1/FGF2/IKBKB/MAP2K6/MICB	4.71389375088437
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	24/2056	46/9376	2.37929284385045	PSMB8/PSMA7/PSMA1/PSMB3/PSMB4/PSMA4/PSMB10/PSMB2/PSMC4/PSMB6/PSMA2/PSME2/PSMA3/PSMB1/PSMB9/PSMA5/PSMF1/PSMD4/PSMC2/PSMB7/PSMD11/PSMD13/PSMD6/PSMD9	4.96976930930068
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	65/2056	181/9376	1.63768084786207	CD14/FCGR3A/FCER1G/CR1/CALM2/CD74/FCGR1A/FCGR2A/HLA-DRA/CLEC7A/MRC1/NFKB1/CTSS/HLA-DPA1/SYK/CALM3/CREB1/TLR4/CD209/CORO1A/ITGB2/RAB5C/BID/HLA-DQA2/TLR1/PPP3R1/TNFRSF1A/ITGAM/IL10RA/CAMK2D/ATP6V0A1/HLA-DMA/BAX/CYCS/LSP1/ATP6V0B/IL10RB/ATP6V0D1/CALML4/HLA-DMB/EEA1/CREBBP/RFXANK/NFYC/IL1B/TLR2/PPP3CB/IRAK2/MALT1/RIPK2/TNF/AKT1/ATP6V1H/CASP10/APAF1/TCIRG1/AKT2/SPHK1/IRAK4/MAPK13/MAPK10/FCGR2B/TGFB3/TLR6/ITGAX	4.59101220205279
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	25/2056	50/9376	2.28015564202335	CD36/CCL2/HBB/HGF/HBA2/HBA1/CR1/VCAM1/CD81/CXCL8/PECAM1/GYPC/TLR4/ICAM1/ITGB2/LRP1/KLRB1/IL1B/SDC2/TLR2/TNF/ITGAL/GYPB/TGFB3/ACKR1	4.80996287180898
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	53/2056	140/9376	1.72640355753196	SPP1/MEF2C/GNG2/RYR2/EGR1/CALM2/GNG11/KLF2/GNAI2/PLCB1/CCND1/GNGT1/GNG5/ITPR2/MEF2A/GNG10/CALM3/SLC8A1/RPS6/GNB4/PRKACB/GNA13/TGFBR1/MAP2K2/PIK3CG/GNAI3/GNB1/GNAQ/PIK3R5/GNB2/PDE3B/CALML4/APLNR/PRKACA/PLCB2/ITPR1/MYLK/RYR1/AKT1/KRAS/MEF2D/HRAS/RPS6KB2/APLN/AGTR1/TFAM/AKT2/NOTCH3/GNG7/SPHK1/PIK3R4/ACTA2/ADCY4	4.58924951833242
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	57/2056	155/9376	1.67701769800427	CD14/CD36/CYBA/FCGR3A/CYBB/HLA-C/COLEC12/TUBA1B/HLA-A/FCGR1A/FCGR2A/MSR1/HLA-DRA/NCF4/CLEC7A/MRC1/TUBA1A/CTSS/C1R/HLA-DPA1/SEC61B/TLR4/ITGB5/ATP6V1F/CD209/CORO1A/ITGB2/ATP6V1G1/RAB5C/HLA-DQA2/SEC61G/ATP6V1D/ITGAM/NCF1/STX7/ATP6V0A1/ATP6V1B2/HLA-DMA/M6PR/ATP6V0B/STX12/ATP6V0D1/NCF2/HLA-DMB/EEA1/PIKFYVE/TLR2/TUBB2A/ATP6V1C1/ACTG1/ATP6V1A/ATP6V1H/TCIRG1/HLA-F/DYNC2H1/FCGR2B/TLR6	4.5042087786545
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	52/2056	138/9376	1.7183781650031	CCL2/JUN/CXCL8/LCP2/FCGR2A/PYCARD/ARPC3/NFKB1/WASF2/CD4/FYB1/ARPC5/TLR4/ELMO1/NLRP3/RHOG/NFATC2/PKN2/WAS/VAV1/CASP1/WIPF1/GIT2/RAC2/MAP2K2/PIK3CD/ACTR2/GNAQ/ROCK1/NFATC3/RPS6KA3/ARPC4/TAB2/PKN1/SKAP2/PIK3R3/IL1B/ACTG1/ITGA4/TNF/WIPF2/MAP3K7/AKT1/AKT2/LIMK1/IRAK4/MAPK13/MAPK10/ARHGEF1/PLCG1/IKBKB/MAP2K6	4.50552434434933
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	29/2056	63/9376	2.09919090852943	POLR2L/GTF2H5/RBX1/PCNA/POLR2K/RPA3/POLR2J/POLR2I/POLR2A/POLR2G/POLR2E/POLR2J3/RAD23A/POLD4/POLE4/XPA/RPA2/POLD2/RFC4/POLE/POLE3/GTF2H3/POLR2B/DDB2/UVSSA/ERCC8/XPC/RFC2/ERCC2	4.63916964139365
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	73/2056	214/9376	1.55562020437107	GNG2/HLA-C/CALM2/JUN/HLA-A/GNG11/PRKCB/AP1S2/GNAI2/PRKCA/NFKB1/GNGT1/CD4/ELOB/GNG5/ITPR2/TNFRSF1B/GNG10/CALM3/TLR4/ELOC/BID/NFATC2/AP1B1/RBX1/RNF7/PPP3R1/GNB4/TNFRSF1A/ATM/RAC2/MAP2K2/PIK3CD/BAX/GNAI3/GNB1/GNAQ/APOBEC3C/CYCS/NFATC3/ATR/FBXW11/GNB2/CUL5/TAB2/CALML4/PIK3R3/TLR2/PPP3CB/RIPK1/ITPR1/TNF/CD247/MAP3K7/AKT1/KRAS/HRAS/CGAS/RPS6KB2/BCL2L1/AKT2/HLA-F/GNG7/LIMK1/IRAK4/MAPK13/MAPK10/CCNB2/APOBEC3G/PLCG1/CDK1/IKBKB/MAP2K6	4.35744009916772
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	53/2056	144/9376	1.67844790315607	RBPJ/PRKCB/PRKCA/PLCB1/SLC1A6/SLC25A6/SLC25A5/ITPR2/ATXN1/PSMA7/PSMA1/PSMB3/PSMB4/GTF2B/PSMA4/PSMB2/PUM2/PSMC4/PSMB6/PSMA2/PIK3CD/VDAC3/RORA/MAP3K5/PSMA3/GNAQ/CYCS/PSMB1/PSMA5/OPA1/VDAC2/PIK3R3/PSMD4/PSMC2/PLCB2/PSMB7/PSMD11/PSMD13/ITPR1/ULK2/RYR1/AKT1/GRIN2C/NOP56/AKT2/PSMD6/PSMD9/CIC/VLDLR/TBPL1/PIK3R4/MAPK10/OMA1	4.34801972409651
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	42/2056	108/9376	1.77345438824038	SUMO2/SAP18/SUMO1/RAN/SUMO3/NUP54/KPNB1/NUP214/UBE2I/KPNA4/RANBP2/MAGOH/XPO1/XPO6/NUP42/PNN/TNPO1/POM121C/SEC13/XPO4/UPF3A/MAGOHB/PYM1/AHCTF1/KPNA2/NUP133/NUP160/NMD3/RAE1/XPO7/THOC1/IPO9/SENP2/SEH1L/THOC6/GLE1/CSE1L/KPNA5/NUP37/NUP88/THOC5/SNUPN	4.28445144902963
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	56/2056	157/9376	1.62660784653895	CCND2/CDK6/HLA-C/CALM2/HLA-A/CXCL8/CCND1/NFKB1/RB1/SLC25A6/SLC25A5/ITPR2/CALM3/NFATC2/PPP3R1/PPP1CB/ATM/TGFBR1/MAP2K2/PIK3CD/VDAC3/EIF4EBP1/NFATC3/ATR/FBXW11/PPP1CA/CALML4/VDAC2/PIK3R3/HIPK1/TP53/PPP3CB/ETS1/ITPR1/SIRT1/GATA4/PPP1CC/NBN/CDK4/AKT1/KRAS/HRAS/RASSF5/CAPN1/AKT2/HLA-F/CDKN2A/E2F3/CHEK2/MAPK13/CCNB2/TGFB3/CDK1/LIN52/RBL1/MAP2K6	4.19609585381588
Organismal Systems	Immune system	hsa04611	Platelet activation	47/2056	126/9376	1.70106849484281	FCER1G/COL3A1/COL1A1/COL1A2/PRKG1/LCP2/FCGR2A/LYN/GNAI2/PLCB1/GUCY1A2/TBXAS1/ITPR2/SYK/GUCY1A1/PPP1CB/FERMT3/PRKACB/GNA13/MYL12A/PIK3CD/PIK3CG/GNAI3/GNAQ/ROCK1/VAMP8/PIK3R5/PPP1CA/TLN1/PIK3R3/PRKACA/APBB1IP/PLCB2/ACTG1/ITPR1/GUCY1B1/PPP1CC/ARHGAP35/MYLK/AKT1/AKT2/BTK/PLA2G4C/MAPK13/ARHGEF1/ADCY4/P2RY1	4.19871609512937
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	32/2056	77/9376	1.89519429986356	RUNX1/CDK6/CCND1/NFKB1/RB1/TGFBR1/MAP2K2/PIK3CD/GRB2/SOS1/GAB2/BAX/BRAF/PIK3R3/HDAC2/TP53/POLK/ABL1/CDK4/AKT1/KRAS/HRAS/BCL2L1/AKT2/CDKN2A/SHC1/DDB2/E2F3/CDKN1B/STAT5A/TGFB3/IKBKB	4.18009545946117
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	32/2056	78/9376	1.8708969370448	CYBA/FCGR3A/CYBB/CR1/JUN/FCGR1A/PRKCB/FCGR2A/HLA-DRA/NCF4/NFKB1/HLA-DPA1/TLR4/ITGB2/HLA-DQA2/ITGAM/NCF1/HLA-DMA/MARCKSL1/TAB2/NCF2/HLA-DMB/IL1B/TLR2/ITGA4/TNF/MAP3K7/PTPN6/IRAK4/NFKBIB/MAPK13/TGFB3	4.09318097046561
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	55/2056	158/9376	1.58745013052258	WNT2/IGF1/PRKCB/PRKCA/LAMTOR4/ATP6V1F/LAMTOR2/LAMTOR5/ATP6V1G1/RPS6/PRR5/TNFRSF1A/ATP6V1D/LRP6/MAP2K2/ATP6V1B2/PIK3CD/EIF4EBP1/EIF4E/GRB2/SOS1/LAMTOR1/BRAF/RPS6KA3/CASTOR1/RICTOR/LAMTOR3/PIK3R3/ATP6V1C1/RRAGA/SEC13/TNF/ATP6V1A/WNT2B/DEPTOR/SKP2/MIOS/STK11/ULK2/AKT1/KRAS/ATP6V1H/HRAS/RPS6KB2/AKT2/SEH1L/FZD2/RRAGB/STRADA/IRS1/STRADB/FZD5/IKBKB/FZD7/DVL2	3.94659761454012
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	49/2056	137/9376	1.63106024027947	CTSC/JUN/TUBA1B/NFKB1/TUBA1A/ITPR2/CTSS/PMAIP1/BID/TNFRSF1A/BCL2A1/ATM/SPTAN1/MAP2K2/PIK3CD/MAP3K5/BAX/CYCS/TNFRSF10B/PARP1/EIF2S1/PIK3R3/TP53/RIPK1/ACTG1/ITPR1/TNF/GZMB/AKT1/KRAS/MAP3K14/HRAS/CASP10/BCL2L1/DAXX/APAF1/CAPN1/AKT2/PRF1/DFFA/LMNB2/CTSO/HTRA2/BIRC2/MAPK10/CTSK/DDIT3/IKBKB/TNFRSF10A	3.94330410917255
Human Diseases	Cancer: specific types	hsa05214	Glioma	31/2056	76/9376	1.86012697112431	CDK6/CALM2/IGF1/PRKCB/PRKCA/CCND1/RB1/CALM3/CAMK2D/MAP2K2/PIK3CD/GRB2/SOS1/BAX/BRAF/CALML4/PIK3R3/TP53/POLK/CDK4/AKT1/KRAS/HRAS/AKT2/CDKN2A/SHC1/DDB2/E2F3/PDGFRB/PLCG1/TGFA	3.98996917780665
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	64/2056	193/9376	1.51222757605693	CCL3/CXCL14/CCL2/CCL4/CCL4L2/GNG2/CCL3L1/GNG11/CXCL8/PRKCB/LYN/GNAI2/PLCB1/DOCK2/NFKB1/GNGT1/GNG5/CCL8/GNG10/ARRB2/ELMO1/HCK/WAS/GNB4/VAV1/PRKACB/PREX1/NCF1/GRK2/RAC2/PIK3CD/STAT3/GRB2/CX3CR1/SOS1/ARRB1/PIK3CG/GNAI3/JAK3/BRAF/GNB1/GNAQ/ROCK1/CCR1/PIK3R5/GNB2/CCL5/CXCL16/PIK3R3/PRKACA/PLCB2/CCL13/CXCL12/AKT1/KRAS/HRAS/AKT2/SHC1/GNG7/CXCL1/NFKBIB/PLCG1/IKBKB/ADCY4	3.81057900597475
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	18/2056	36/9376	2.28015564202335	SSBP1/PCNA/RPA3/RNASEH2B/RNASEH2C/POLD4/POLE4/MCM5/RPA2/POLD2/RFC4/POLE/POLE3/RFC2/POLA1/RNASEH1/MCM3/MCM7	4.07832883285172
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	38/2056	101/9376	1.71576068112648	CCL2/COL3A1/CYBB/COL1A1/COL1A2/MMP2/EGR1/JUN/VCAM1/CXCL8/PRKCB/PRKCA/PLCB1/CCND1/NFKB1/ICAM1/TGFBR1/PIK3CD/STAT3/BAX/PIK3R3/IL1B/PLCB2/TNF/VEGFC/CDK4/AKT1/KRAS/HRAS/AGTR1/AKT2/CDKN1B/STAT5A/MAPK13/MAPK10/TGFB3/PLCG1/PLCE1	3.83277405661155
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	35/2056	91/9376	1.7539658784795	JUN/CD81/PRKCB/LYN/NFKB1/LILRB5/SYK/PIK3AP1/INPP5D/NFATC2/PPP3R1/VAV1/RAC2/MAP2K2/PIK3CD/GRB2/SOS1/NFATC3/PIK3R3/PPP3CB/MALT1/RASGRP3/AKT1/KRAS/PTPN6/HRAS/LILRB1/AKT2/NFKBIE/BTK/NFKBIB/LILRB3/BLNK/FCGR2B/IKBKB	3.83021441858411
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	28/2056	68/9376	1.87777523460746	CD14/RUNX1/DUSP6/RUNX1T1/SPI1/FCGR1A/CCND1/NFKB1/CSF1R/ITGAM/BCL2A1/MAP2K2/PIK3CD/EIF4EBP1/STAT3/GRB2/SOS1/BRAF/PIK3R3/LEF1/TCF7/AKT1/KRAS/HRAS/RPS6KB2/AKT2/STAT5A/IKBKB	3.84991592521994
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	31/2056	78/9376	1.81243140776215	CD14/C1QA/C1QC/C1QB/LY96/CALM2/JUN/CXCL8/PYCARD/GNAI2/NFKB1/C1R/C2/CALM3/TLR4/ITGB2/NLRP3/ITGAM/CASP1/IRF1/GNAI3/CALML4/IL1B/TNF/C4BPB/IRF8/IRAK4/MAPK13/MAPK10/C1S/NOD1	3.81839530788195
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	30/2056	75/9376	1.82412451361868	CCND2/CDK6/IGF1/CCND1/PMAIP1/BID/ATM/ZMAT3/BAX/CYCS/TNFRSF10B/ATR/MDM4/SIVA1/TP53/SESN3/EI24/CDK4/RCHY1/BCL2L1/APAF1/CDKN2A/DDB2/CCNG1/CHEK2/CD82/CCNB2/RRM2B/CDK1/TNFRSF10A	3.7975219673113
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	66/2056	204/9376	1.47539482719158	LUM/DCN/COL1A1/WNT2/HGF/COL1A2/MMP2/IGF1/GPC3/PRKCB/PRKCA/CCND1/HIF1A/ITPR2/ANK2/MSN/TLR4/ITGB5/TWIST1/RPS6/PLAUR/DDX5/PLAU/PPP1CB/VAV1/PRKACB/CAMK2D/MAP2K2/PIK3CD/STAT3/GRB2/SOS1/BRAF/ROCK1/PPP1CA/PIK3R3/SDC2/PRKACA/TP53/TLR2/ACTG1/ITPR1/TNF/WNT2B/PPP1CC/KDR/ANK3/AKT1/KRAS/PTPN6/HRAS/VTN/RPS6KB2/NUDT16L1/AKT2/HBEGF/TWIST2/FZD2/MAPK13/ARHGEF1/PLCG1/PLCE1/FZD5/FGF2/FZD7/PTCH1	3.63813797373397
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	68/2056	212/9376	1.46274135526026	HGF/MAGI1/CALM2/DOCK4/PDGFC/IGF1/LCP2/PRKCB/GNAI2/PRKCA/PLCB1/FYB1/FGF7/CALM3/PFN1/ITGB2/FPR1/KITLG/ANGPT1/ENAH/VAV1/CSF1R/MAGI3/ITGAM/RAPGEF6/RAC2/MAP2K2/PIK3CD/GNAI3/BRAF/GNAQ/SIPA1L2/CALML4/EFNA5/TLN1/PIK3R3/SIPA1/SIPA1L3/APBB1IP/PLCB2/LPAR5/ACTG1/CSF1/FARP2/VEGFC/ITGAL/TEK/KDR/RAPGEF5/RASGRP3/AKT1/KRAS/HRAS/RASSF5/AKT2/PFN2/SKAP1/FGFR3/PRKD2/PDGFRB/MAPK13/PLCG1/PLCE1/RAP1GAP/FGF2/ADCY4/P2RY1/MAP2K6	3.61164750871841
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	78/2056	250/9376	1.42281712062257	DAB2/FOLR2/WWP1/HLA-C/SNX6/HLA-A/PLD1/CLTC/ARPC3/HSPA1A/EPS15/PSD3/SNX2/BIN1/CYTH4/VPS29/CLTA/VPS28/ARPC5/ARRB2/ACAP2/AP2S1/RAB5C/CAPZB/CHMP4A/CAPZA2/SMURF2/GRK2/WIPF1/ARAP1/GIT2/TGFBR1/CHMP2A/ZFYVE16/KIF5B/ARRB1/RAB10/ARF5/ACTR2/RAB11A/AP2M1/CHMP5/ARAP2/RABEP1/ARPC4/EPN1/MVB12B/EEA1/CAPZA1/ARF3/EHD4/GIT1/VPS45/EPS15L1/SPG21/VPS35/WIPF2/IL2RA/SNX1/RUFY1/SNX4/HRAS/RAB11FIP2/CYTH2/HLA-F/CHMP6/ARFGAP2/NEDD4L/RBSN/FGFR3/VPS37C/RNF41/WASHC5/WASHC2C/HSPA6/WASHC1/IL2RG/IQSEC2	3.59107097968077
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	31/2056	80/9376	1.76712062256809	HGF/PDGFC/IGF1/PRKCB/GAS6/PRKCA/RPS6/MAP2K2/PIK3CD/EIF4EBP1/STAT3/EIF4E/GRB2/SOS1/BAX/BRAF/PIK3R3/KDR/IL6R/AKT1/KRAS/HRAS/RPS6KB2/BCL2L1/AKT2/SHC1/FGFR3/PDGFRB/PLCG1/TGFA/FGF2	3.6517601653902
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	33/2056	87/9376	1.72977324567288	MT-CYB/MT-CO2/MT-CO1/MT-CO3/ATP1B3/RYR2/COX6C/UQCR10/COX4I1/ATP1B1/COX7B/COX5B/COX8A/UQCRB/COX6B1/UQCRQ/COX4I2/COX7C/COX7A2/SLC8A1/UQCRH/CACNB4/TPM3/COX6A1/UQCR11/UQCRC2/COX5A/UQCRFS1/CYC1/CACNA2D1/CACNA2D4/COX7A1/SLC9A6	3.62413807421519
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	40/2056	112/9376	1.62868260144525	LAMA2/LY96/HLA-DRA/GNAI2/HSPA1A/NFKB1/LAMA4/HLA-DPA1/TLR4/HLA-DQA2/TNFRSF1A/IL10RA/LAMB2/HLA-DMA/STAT3/PIK3CG/GNAI3/CYCS/PIK3R5/IL10RB/TAB2/LAMC1/HLA-DMB/TLR2/LAMC3/TNF/MAP3K7/AKT1/BCL2L1/ALOX5/AKT2/IRAK4/NFKBIB/BIRC2/MAPK13/MAPK10/HSPA6/TGFB3/IKBKB/MAP2K6	3.54717677746567
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	38/2056	105/9376	1.65039836946452	FCER1G/CALM2/JUN/PYCARD/CLEC7A/NFKB1/ITPR2/SYK/CALM3/CD209/NLRP3/NFATC2/PPP3R1/EGR2/CASP1/PIK3CD/IRF1/LSP1/NFATC3/CYLD/CALML4/PIK3R3/IL1B/PPP3CB/RELB/MALT1/ITPR1/TNF/AKT1/KRAS/MAP3K14/HRAS/EGR3/AKT2/IRF9/MAPK13/MAPK10/IKBKB	3.55183232700049
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	36/2056	98/9376	1.67521639005797	FCGR3A/MARCKS/PTPRC/PLD1/FCGR1A/PRKCB/FCGR2A/LYN/PRKCA/ARPC3/WASF2/BIN1/SYK/ARPC5/HCK/INPP5D/WAS/VAV1/NCF1/RAC2/PLPP3/PIK3CD/GAB2/ACTR2/MARCKSL1/ARPC4/PIK3R3/SCIN/AKT1/RPS6KB2/AKT2/LIMK1/PLA2G4C/SPHK1/FCGR2B/PLCG1	3.56098777152172
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	90/2056	300/9376	1.36809338521401	CD14/MEF2C/HGF/AREG/DUSP6/JUN/PDGFC/IGF1/PRKCB/MKNK1/MAP3K8/PRKCA/HSPA1A/NFKB1/STMN1/FGF7/ARRB2/KITLG/PPP3R1/ANGPT1/CSF1R/MAP3K1/TNFRSF1A/PRKACB/MAP3K20/CACNB4/MAP3K13/MAP4K4/DUSP3/NLK/TGFBR1/RAC2/MAP2K2/GRB2/SOS1/ARRB1/MAP3K5/BRAF/NFATC3/MAP2K5/RPS6KA3/MAX/TAB2/RASA2/STK4/MAP3K3/EFNA5/PPM1A/LAMTOR3/IL1B/PRKACA/TP53/PPP3CB/RELB/CSF1/TNF/MAP3K4/VEGFC/TEK/KDR/MAP3K7/MAPKAPK3/RASGRP3/AKT1/KRAS/CACNA2D1/MAP3K14/HRAS/BDNF/DAXX/AKT2/CDC25B/PLA2G4C/FGFR3/ELK4/IRAK4/CACNA2D4/PDGFRB/MAPK13/MAPK10/DUSP7/HSPA6/DDIT3/TGFB3/TGFA/MAP3K11/FGF2/IKBKB/MAP2K6/MAP4K2	3.43410088654599
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	48/2056	142/9376	1.54151367348057	CCL2/CYBA/MEF2C/MMP2/CALM2/JUN/VCAM1/KLF2/PECAM1/NFKB1/BMP4/MEF2A/SUMO2/CALM3/ICAM1/ACVR2A/TNFRSF1A/NCF1/MGST2/GSTO1/RAC2/SUMO1/PIK3CD/SUMO3/MAP3K5/CDH5/MAP2K5/NCF2/CALML4/NFE2L2/PIK3R3/IL1B/SDC2/TP53/ACTG1/TNF/KDR/TXN2/MAP3K7/AKT1/BMPR1A/GSTA4/AKT2/MAPK13/MAPK10/KEAP1/IKBKB/MAP2K6	3.44588133093182
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	52/2056	157/9376	1.51042157178617	CD36/C1QA/C1QC/C1QB/GAS6/STAB1/PECAM1/HIF1A/CREB1/PROS1/ITGB5/ELMO1/RAB5C/NFATC2/ADAM9/CD47/LRP1/CASP1/CAMK2D/MAP2K2/SIRPA/CX3CR1/NFATC3/PTGER4/PLA2G15/DNMT3A/GULP1/VPS8/LIPA/RAB14/HAVCR2/UQCRFS1/ODC1/SIRT1/STAB2/ATP11B/ATP8A1/PTPN6/ALOX5/ATP11C/PBX1/SPHK1/S1PR1/ARG2/VPS16/VPS11/VPS33A/CD24/MAPK13/DUSP7/SLC66A1/CH25H	3.41805142227338
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	27/2056	69/9376	1.78446963288784	FCER1G/LCP2/LYN/PRKCA/SYK/INPP5D/VAV1/RAC2/MAP2K2/PIK3CD/GRB2/SOS1/GAB2/ALOX5AP/PIK3R3/TNF/AKT1/KRAS/HRAS/ALOX5/AKT2/BTK/PLA2G4C/MAPK13/MAPK10/PLCG1/MAP2K6	3.46607118442901
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	35/2056	97/9376	1.64547314372819	GNG2/PRKG1/RYR2/CALM2/GNG11/PRKCB/GNAI2/PRKCA/PLCB1/GNGT1/GUCY1A2/GNG5/GNG10/CALM3/CREB1/GUCY1A1/GNB4/PRKACB/CAMK2D/GNAI3/GNB1/GNAQ/KCNJ5/GNB2/GRIA4/CALML4/PRKACA/PLCB2/PER3/ITPR1/GUCY1B1/RYR1/GRIN2C/GNG7/ADCY4	3.38653142412945
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	32/2056	87/9376	1.67735587459189	AREG/JUN/CCND1/PMAIP1/TGFBR1/RAC2/MAP2K2/PIK3CD/GRB2/SOS1/BAX/BRAF/CYCS/APC/MSH3/PIK3R3/APPL1/TP53/POLK/LEF1/TCF7/AKT1/KRAS/HRAS/RPS6KB2/MSH6/AKT2/DDB2/MLH1/MAPK10/TGFB3/TGFA	3.36382736618184
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	44/2056	130/9376	1.54348997306196	COL3A1/GNG2/COL1A1/COL1A2/MMP2/JUN/GNG11/GNAI2/PRKCA/PLCB1/NFKB1/GNGT1/GNG5/GNG10/CREB1/ARRB2/MMP1/GNB4/PRKACB/TGFBR1/GNA15/MAP2K2/PIK3CD/GRB2/SOS1/ARRB1/GNAI3/GNB1/GNB2/PIK3R3/PRKACA/PLCB2/VEGFC/AKT1/KRAS/HRAS/AKT2/SHC1/GNG7/CREB3L1/MAPK13/MAPK10/ACTA2/ADCY4	3.30695222333602
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	64/2056	205/9376	1.42370693745848	CCND2/VIM/CDK6/HLA-C/JUN/RBPJ/HLA-A/LYN/HLA-DRA/CCND1/NFKB1/RB1/HLA-DPA1/SYK/ICAM1/BID/HLA-DQA2/PSMC4/HLA-DMA/PIK3CD/STAT3/BAX/JAK3/CYCS/TAB2/HLA-DMB/PIK3R3/HDAC2/TP53/POLK/TLR2/PSMD4/PSMC2/RIPK1/RELB/PSMD11/PSMD13/TNF/CD247/ITGAL/SKP2/ENTPD8/MAP3K7/CD58/CDK4/AKT1/MAP3K14/APAF1/AKT2/PSMD6/HLA-F/NFKBIE/DDB2/BTK/E2F3/IRAK4/CDKN1B/NFKBIB/IRF9/MAPK13/MAPK10/BLNK/IKBKB/MAP2K6	3.25069191807269
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	38/2056	109/9376	1.589833291686	CD14/CCL3/SPP1/CCL4/CCL4L2/CCL3L1/LY96/JUN/CXCL8/MAP3K8/CD86/NFKB1/TLR4/TLR1/MAP2K2/PIK3CD/TAB2/TLR7/CCL5/PIK3R3/IL1B/TLR2/RIPK1/TNF/MAP3K7/AKT1/AKT2/TLR5/TLR8/IRAK4/IRF9/MAPK13/MAPK10/CTSK/TLR6/IRF5/IKBKB/MAP2K6	3.28257457886051
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	12/2056	23/9376	2.37929284385045	SSBP1/PCNA/RPA3/MSH3/POLD4/RPA2/MSH6/POLD2/RFC4/MLH3/MLH1/RFC2	3.50983408038533
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	76/2056	253/9376	1.36989587979268	CD14/RPS27A/UBA52/UBB/JUN/CXCL8/PYCARD/ARPC3/PLCB1/NFKB1/WASF2/CYTH4/SEPTIN7/ITPR2/ARPC5/TLR4/ELMO1/PFN1/NLRP3/RBX1/TNFRSF1A/ATM/CASP1/MYL12A/PIK3CD/SEPTIN11/BAX/ACTR2/TIFA/ROCK1/CYCS/FBXW11/FNBP1/ARPC4/TAB2/UBE2D3/CCL5/TLN1/UBE2D1/PIK3R3/IL1B/TP53/SEPTIN6/PLCB2/RIPK1/ACTG1/RRAGA/MALT1/RIPK2/ITPR1/TNF/MAP3K7/AKT1/CGAS/RPS6KB2/BCL2L1/NAIP/CAPN1/AKT2/CYTH2/CASP4/TLR5/GLMN/PFN2/RRAGB/U2AF1/PIK3R4/NFKBIB/TAB3/MAPK13/MAPK10/PLCG1/NOD1/PLCE1/U2AF1L4/IKBKB	3.16091319784016
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	27/2056	71/9376	1.73420288266564	JUN/CXCL8/LYN/NFKB1/ATP6V1F/ATP6V1G1/ATP6V1D/ATP6V0A1/ATP6V1B2/CSK/ATP6V0B/ATP6V0D1/CCL5/GIT1/ATP6V1C1/ATP6V1A/ATP6V1H/MAP3K14/JAM3/TCIRG1/HBEGF/CXCL1/MAPK13/MAPK10/PLCG1/NOD1/IKBKB	3.29100637661778
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	42/2056	125/9376	1.53226459143969	FCER1G/PLD1/PRKCB/SGMS1/GNAI2/PRKCA/PLCB1/ASAH1/NFKB1/BID/SPTSSA/TNFRSF1A/GNA13/RAC2/MAP2K2/PIK3CD/GAB2/MAP3K5/BAX/GNAI3/GNAQ/ROCK1/PPP2R5C/PPP2CB/PIK3R3/TP53/PLCB2/NSMAF/TNF/PPP2R3C/AKT1/KRAS/HRAS/AKT2/ORMDL1/SPTLC3/SPHK1/S1PR1/PPP2R5B/MAPK13/SGPL1/MAPK10	3.17489885944934
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	44/2056	133/9376	1.50867440975981	GNG2/CALM2/GNG11/PRKCB/GNAI2/PRKCA/PLCB1/GNGT1/GNG5/ITPR2/GNG10/CALM3/CREB1/ARRB2/PPP1CB/GNB4/PRKACB/CAMK2D/KIF5B/ARRB1/GNAI3/GNB1/GNAQ/KCNJ5/GNB2/PPP2R5C/GRIA4/PPP1CA/CALML4/PPP2CB/PRKACA/PPP3CB/PLCB2/CLOCK/ITPR1/PPP1CC/PPP2R3C/AKT1/AKT2/GNG7/PPP2R5B/CREB3L1/MAPK13/MAPK10	3.13112846685846
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	32/2056	90/9376	1.62144401210549	JUN/HIF1A/NFKB1/EML4/CD4/CD28/TLR4/NFATC2/PPP3R1/MAP2K2/PIK3CD/STAT3/NFATC3/MAP3K3/CSNK2A1/PIK3R3/TLR2/PPP3CB/CD247/AKT1/KRAS/PTPN6/HRAS/RPS6KB2/AKT2/NFKBIE/NFKBIB/MAPK13/PLCG1/BATF/IKBKB/MAP2K6	3.13942834906159
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	23/2056	59/9376	1.77774846666227	ENPP1/NME2/DPYD/NME3/TYMP/NT5C/DUT/NME1/CTPS2/RRM1/DCK/NME4/DTYMK/TK2/ENTPD8/HDDC2/NME6/NT5C3A/TYMS/AK9/DCTPP1/RRM2B/UCK1	3.17591429794268
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	14/2056	30/9376	2.12814526588846	FOLR2/NFKB1/ABCC5/MTHFR/IL1B/TNF/ABCG2/MTR/TYMS/ABCC4/SLC46A1/GART/IKBKB/SHMT2	3.27985328440161
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	39/2056	116/9376	1.53320810411915	CYBA/CYBB/MMP2/VCAM1/PRKCB/PECAM1/GNAI2/NCF4/PRKCA/ARHGAP5/MSN/ICAM1/CD99/ITGB2/CLDN5/VAV1/ITGAM/NCF1/RAC2/MYL12A/PIK3CD/GNAI3/THY1/ROCK1/CDH5/NCF2/TXK/PIK3R3/SIPA1/ACTG1/ITGA4/ITGAL/CXCL12/ARHGAP35/RASSF5/JAM3/MAPK13/PLCG1/CLDN11	3.06239985580933
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	49/2056	154/9376	1.45100813583304	MEF2C/RYR2/CALM2/JUN/PRKCB/GNAI2/PRKCA/PLCB1/CCND1/GUCY1A2/ITPR2/CALM3/GUCY1A1/MYL6/NFATC2/PPP3R1/PPP1CB/PRKACB/TRPM2/CACNB4/CAMK2D/MAP2K2/PIK3CG/GNAI3/GNAQ/ROCK1/KCNJ5/NFATC3/MAP2K5/PIK3R5/RGS2/PPP1CA/CALML4/CD38/PRKACA/PPP3CB/PLCB2/ACTG1/ITPR1/GUCY1B1/PPP1CC/MYLK/RYR1/KRAS/CACNA2D1/HRAS/PLA2G4C/CACNA2D4/ADCY4	2.99070674773546
Organismal Systems	Nervous system	hsa04730	Long-term depression	23/2056	60/9376	1.74811932555123	PRKG1/IGF1/PRKCB/LYN/GNAI2/PRKCA/PLCB1/GUCY1A2/ITPR2/GUCY1A1/GNA13/MAP2K2/GNAI3/BRAF/GNAQ/PPP2CB/PLCB2/ITPR1/GUCY1B1/RYR1/KRAS/HRAS/PLA2G4C	3.0808702730082
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	52/2056	166/9376	1.42853124560499	MEF2C/PRKG1/ATP1B3/CALM2/ATP1B1/ATP2B1/GTF2I/GNAI2/PLCB1/GUCY1A2/SLC25A6/SLC25A5/ITPR2/MEF2A/CALM3/CREB1/SLC8A1/GUCY1A1/PDE3A/NFATC2/PPP3R1/PPP1CB/GNA13/MAP2K2/VDAC3/PIK3CG/GNAI3/GNAQ/ROCK1/NFATC3/PIK3R5/PDE3B/RGS2/ADRB1/PPP1CA/CALML4/VDAC2/PPP3CB/PLCB2/ITPR1/GUCY1B1/GATA4/PPP1CC/MYLK/AKT1/MEF2D/AGTR1/AKT2/CREB3L1/IRS1/ADCY4/PDE5A	2.95221766785982
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	25/2056	67/9376	1.70160868807712	CALM2/PRKCB/PRKCA/PLCB1/ITPR2/CALM3/PPP3R1/PPP1CB/PRKACB/CAMK2D/MAP2K2/BRAF/GNAQ/RPS6KA3/PPP1CA/CALML4/CREBBP/PRKACA/PPP3CB/PLCB2/ITPR1/PPP1CC/KRAS/GRIN2C/HRAS	3.05437599132044
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	34/2056	99/9376	1.5661675116928	MMP2/JUN/IGF1/CCND1/RB1/PRKACB/MAP2K2/PIK3CD/GRB2/SOS1/BAX/BRAF/PIK3R3/PRKACA/TP53/CDK4/AKT1/KRAS/HRAS/RPS6KB2/AKT2/NOTCH3/MED1/HBEGF/NOTCH1/CDKN2A/SHC1/E2F3/CDKN1B/DLL4/MAPK13/MAPK10/JAG2/ADCY4	3.00123786118473
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	16/2056	37/9376	1.97202650120938	HBB/HBA2/HBA1/VCAM1/PRKCB/PRKCA/PLCB1/LAMA4/ICAM1/GNAQ/IDO2/IL1B/PLCB2/TNF/IDO1/THOP1	3.13957189584324
Human Diseases	Infectious disease: viral	hsa05162	Measles	44/2056	136/9376	1.47539482719158	CCND2/CDK6/JUN/CCND1/HSPA1A/NFKB1/RACK1/MSN/CD28/TLR4/CD209/BID/PIK3CD/STAT3/BAX/JAK3/CYCS/TAB2/TLR7/EIF2S1/CSNK2A1/PIK3R3/IL1B/TP53/TLR2/RAB9A/IL2RA/MAP3K7/CDK4/AKT1/RCHY1/BCL2L1/APAF1/AKT2/IRAK4/CDKN1B/STAT5A/NFKBIB/IRF9/MAPK10/HSPA6/FCGR2B/IKBKB/IL2RG	2.95957652050529
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	35/2056	103/9376	1.54962033923917	CCL3/CCL2/C1QA/C1QC/CCL3L1/C1QB/JUN/CXCL8/GNAI2/PLCB1/NFKB1/TLR4/TNFRSF1A/GNA14/TGFBR1/GNA15/PIK3CD/GNAI3/GNAQ/CCL5/PPP2CB/PIK3R3/IL1B/TLR2/PLCB2/TNF/CD247/AKT1/AKT2/IRAK4/MAPK13/MAPK10/TGFB3/TLR6/IKBKB	2.9724388650773
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	35/2056	103/9376	1.54962033923917	CD14/COL3A1/LAMA2/COL1A1/COL1A2/CXCL8/PRKCB/PRKCA/PLCB1/NFKB1/LAMA4/TLR4/SERPINB9/ITGB2/RAB5C/PRKACB/GNA14/ITGAM/LAMB2/GNA15/PIK3CD/SERPINB6/GNAQ/LAMC1/PIK3R3/IL1B/PRKACA/TLR2/PLCB2/LAMC3/TNF/ARG2/CXCL1/TGFB3/C9	2.9724388650773
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	19/2056	47/9376	1.84353009355079	LDHB/ME2/AKR1A1/ME1/MDH1/MDH2/HAGH/FH/ALDH9A1/PDHB/ACACA/GRHPR/DLD/ACSS1/ALDH7A1/PCK2/ACAT1/ACSS2/ALDH3A2	3.07237071042909
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	28/2056	78/9376	1.6370348199142	BTG2/LSM3/LSM7/LSM8/LSM6/LSM5/C1D/LSM4/TENT4B/CNOT4/XRN1/CNOT2/DHX36/DCP1A/CNOT7/NUDT16/CNOT6L/PABPC4L/EXOSC7/TENT4A/EXOSC8/EXOSC6/PATL1/DIS3L/EXOSC3/MPHOSPH6/DCPS/EXOSC9	2.99403832013094
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	40/2056	122/9376	1.49518402755629	PTPRC/JUN/LCP2/MAP3K8/NFKB1/CD4/CD28/NFATC2/PPP3R1/VAV1/MAP2K2/PIK3CD/NCK2/GRB2/SOS1/NFATC3/PPP2R5C/TEC1/PPP2CB/PIK3R3/PPP3CB/MALT1/TNF/CD247/MAP3K7/CDK4/PPP2R3C/AKT1/KRAS/PTPN6/MAP3K14/HRAS/AKT2/NFKBIE/NFKBIB/PPP2R5B/MAPK13/MAPK10/PLCG1/IKBKB	2.91758453584814
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	32/2056	93/9376	1.5691393665537	MMP2/EGR1/CALM2/JUN/PLD1/PRKCB/PRKCA/PLCB1/ITPR2/CALM3/MAP3K1/PRKACB/CAMK2D/MAP2K2/GRB2/SOS1/GNAQ/MAP3K3/CALML4/CGA/PRKACA/PLCB2/ITPR1/MAP3K4/KRAS/HRAS/HBEGF/PLA2G4C/MAPK13/MAPK10/ADCY4/MAP2K6	2.92319359249634
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	70/2056	238/9376	1.34126802471962	GNG2/HGF/CALM2/GNG11/PDGFC/PLD1/IGF1/PRKCB/PRKCA/RGL1/NFKB1/GNGT1/GNG5/FGF7/GNG10/CALM3/RAB5C/KITLG/ANGPT1/GNB4/CSF1R/PRKACB/REL/RAC2/MAP2K2/PIK3CD/GRB2/SOS1/GAB2/GNB1/RASA3/GNB2/RALGAPA2/RALGAPA1/RASA2/STK4/CALML4/EFNA5/PIK3R3/PRKACA/ABL1/ETS1/CSF1/VEGFC/TEK/ABL2/KDR/RAPGEF5/RASGRP3/AKT1/KRAS/HRAS/RASSF5/RASA4/BCL2L1/RASSF1/BDNF/AKT2/SHC1/GNG7/PLA2G4C/FGFR3/RASAL3/PDGFRB/MAPK10/PLCG1/TGFA/PLCE1/FGF2/IKBKB	2.82618217705005
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	17/2056	41/9376	1.89086077631204	MMP2/CXCL8/CCND1/RB1/MMP1/TYMP/MAP2K2/BRAF/TP53/CDK4/KRAS/HRAS/RASSF1/HBEGF/CDKN2A/E2F3/FGFR3	3.029606737006
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	45/2056	142/9376	1.44516906888804	RPS27A/WWP1/UBA52/UBB/ELOB/PIAS2/UBE2W/ELOC/ANAPC11/UBE2E3/RBX1/RNF7/SMURF2/MAP3K1/CDC34/PRKN/SOCS3/UBE2S/CDC27/FBXW11/UBE2I/CUL5/RHOBTB1/UBE2B/UBE2D3/UBE2D1/UBE2C/UBA6/CDC16/UBE2J1/CUL7/STUB1/SKP2/ANAPC15/FBXO4/RCHY1/ANAPC10/HERC2/ANAPC7/DDB2/NEDD4L/ERCC8/BIRC2/FANCL/KEAP1	2.8327997218054
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	19/2056	48/9376	1.80512321660182	HMGCLL1/BCAT1/HADHB/HIBCH/ECHS1/IVD/ACAA1/HSD17B10/ALDH9A1/ACAA2/AUH/DLD/HADH/ALDH7A1/ABAT/MCCC1/ACAT1/ALDH3A2/ACSF3	2.96367347345224
NA	NA	hsa04517	IgSF CAM signaling	85/2056	299/9376	1.29640956235441	NRP1/SLIT2/MTSS1/MAGI1/TUBA1B/PTPRD/CADM3/LCP2/PRKCB/LYN/DYNLL1/EPB41L2/PRKCA/ARPC3/CD86/PMP22/TUBA1A/NRP2/ROBO1/ANK2/MSN/ARPC5/CD28/UNC5C/ICAM1/LMO7/MYL6/CD209/DOK2/ITGB2/INPP5D/ROBO2/MAG/EPB41L3/CASK/VAV1/ITGAM/IL1RAPL1/RAPGEF6/SPTAN1/MAP2K2/MYL12A/PIK3CD/NCK2/GRB2/ACTR2/CSK/ICAM2/KIRREL1/MYH10/MBP/CD84/NLGN4X/ARPC4/SLIT3/PIK3R3/ABL1/TUBB2A/GIT1/ACTG1/ITGA4/ITGAL/CD48/KDR/MYLK/ANK3/AKT1/LRFN5/PTPN6/EPB41L1/SRGAP3/ICAM3/JAM3/NCAM2/AKT2/DOK1/SLITRK4/UNC5B/NRCAM/MAPK13/MAPK10/PLCG1/ITGAX/CADM2/NECTIN3	2.76056698294607
Organismal Systems	Endocrine system	hsa04924	Renin secretion	25/2056	69/9376	1.65228669711837	CALM2/GNAI2/PLCB1/GUCY1A2/ITPR2/CALM3/CREB1/GUCY1A1/PDE3A/PPP3R1/PRKACB/GNAI3/GNAQ/PTGER4/PDE3B/ADRB1/CALML4/PRKACA/PPP3CB/PLCB2/ITPR1/AQP1/GUCY1B1/AGTR1/PDE1C	2.88203906191434
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	39/2056	120/9376	1.48210116731518	CALM2/JUN/NFKB1/SH2B3/CALM3/MAP3K1/CAMK2D/MAP2K2/PIK3CD/GRB2/SOS1/MAP3K5/BAX/BRAF/MAP2K5/RPS6KA3/KIDINS220/MAP3K3/CALML4/PIK3R3/TP53/ABL1/IRAK2/RIPK2/AKT1/KRAS/HRAS/BDNF/AKT2/NFKBIE/SHC1/IRAK4/NFKBIB/MAPK13/MAPK10/IRS1/PLCG1/IKBKB/MATK	2.816817991141
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	60/2056	201/9376	1.3612869504617	CD14/MEF2C/MAF/CCND2/RUNX1/DUSP6/NR4A3/RUNX1T1/CXCL8/IGF1/SPI1/FCGR1A/BMP2K/CD86/NFKB1/NFKBIZ/FLI1/LMO2/ETV5/DDX5/PROM1/PLAU/KLF3/CSF1R/REL/ITGAM/BCL2A1/ATM/ETV6/TSPAN7/ID2/BAX/LYL1/PBX3/MAX/NUPR1/CDK14/HDAC2/MITF/HHEX/TP53/POLK/JMJD1C/GZMB/BCL2L1/NSD2/CCNT1/MEIS1/DDB2/PBX1/HOXA10/MLLT1/ETV1/ELK4/CDKN1B/TCF3/BIRC2/TFE3/DDIT3/SMAD1	2.74403041236644
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	50/2056	163/9376	1.39886849203886	JUN/CXCL8/PRKCB/PRKCA/NFKB1/RB1/YWHAB/CREB1/TLR4/BID/NFATC2/EGR2/MAP3K1/PCNA/TGFBR1/MAP2K2/PIK3CD/VDAC3/STAT3/GRB2/SOS1/BAX/JAK3/BRAF/CYCS/NFATC3/TAB2/CREBBP/PIK3R3/TP53/TLR2/TNF/MAP3K7/AKT1/KRAS/HRAS/CASP10/APAF1/EGR3/AKT2/DDB2/E2F3/IRAK4/STAT5A/CREB3L1/MAPK13/MAPK10/TGFB3/IKBKB/MAP2K6	2.72247970368911
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	27/2056	77/9376	1.59907019050988	CDK6/PLD1/CCND1/NFKB1/RB1/TGFBR1/RAC2/PIK3CD/STAT3/BAX/BRAF/PIK3R3/TP53/POLK/CDK4/AKT1/KRAS/RPS6KB2/BCL2L1/AKT2/CDKN2A/DDB2/E2F3/MAPK10/TGFB3/TGFA/IKBKB	2.79734866903258
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	25/2056	70/9376	1.62868260144525	LAMA2/HLA-C/HLA-A/HLA-DRA/CD86/CCND1/HLA-DPA1/EIF4G3/CD28/ICAM1/DTNA/ITGB2/BID/HLA-DQA2/RAC2/HLA-DMA/CYCS/HLA-DMB/SGCE/ABL1/ACTG1/ITGAL/ABL2/PRF1/HLA-F	2.79795412989079
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	56/2056	187/9376	1.36565471607815	CCL2/CYBA/CYBB/IFI16/JUN/CXCL8/NAMPT/ANTXR1/PYCARD/PLCB1/NFKB1/ITPR2/GABARAP/TANK/TLR4/NLRP3/CARD16/PKN2/TRPM2/GPSM3/GABARAPL2/CASP1/VDAC3/ERBIN/TAB2/CCL5/PKN1/NLRP1/VDAC2/IL1B/PLCB2/RIPK1/RIPK2/ITPR1/TNF/SUGT1/CARD8/PSTPIP1/TXN2/MAP3K7/TRIP6/BCL2L1/NAIP/CASP4/CXCL1/IRAK4/NFKBIB/TAB3/IRF9/BIRC2/MAPK13/MAPK10/NOD1/GBP2/IKBKB/BRCC3	2.67669883252517
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	30/2056	89/9376	1.53718357889214	PRKG1/TUBA1B/PDGFC/PRKCB/GNAI2/PRKCA/PLCB1/TUBA1A/GUCY1A2/ITPR2/GUCY1A1/GJA1/PRKACB/MAP2K2/GRB2/SOS1/GNAI3/GNAQ/MAP2K5/ADRB1/PRKACA/PLCB2/TUBB2A/ITPR1/GUCY1B1/KRAS/HRAS/PDGFRB/CDK1/ADCY4	2.69849527323294
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	31/2056	93/9376	1.5201037613489	MAF/JUN/RBPJ/IL12RB2/HLA-DRA/NFKB1/CD4/HLA-DPA1/NFATC2/HLA-DQA2/PPP3R1/MAML2/HLA-DMA/JAK3/NFATC3/HLA-DMB/PPP3CB/CD247/IL2RA/NOTCH3/NOTCH1/NFKBIE/STAT5A/NFKBIB/DLL4/MAPK13/MAPK10/JAG2/PLCG1/IKBKB/IL2RG	2.67133864208793
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	52/2056	173/9376	1.37072940329727	CCL2/CDK6/CXCL8/PRKCB/PYCARD/HLA-DRA/PRKCA/NFKB1/SLC25A6/SLC25A5/HLA-DPA1/TLR4/ICAM1/NLRP3/BID/HLA-DQA2/TNFRSF1A/CASP1/MAP2K2/SOCS3/HLA-DMA/PIK3CD/BAX/RAB11A/CYCS/TNFRSF10B/XPO1/TLR7/PABPN1/EIF2S1/CCL5/HLA-DMB/CREBBP/PIK3R3/IL1B/IL33/ACTG1/TNF/KPNA2/CDK4/AKT1/RAE1/FDPS/APAF1/AKT2/TRIM25/KPNA5/IRAK4/NFKBIB/IRF9/IKBKB/TNFRSF10A	2.60829690205413
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	14/2056	34/9376	1.87777523460746	POLR2L/POLR2K/POLR2J/POLR2I/POLR2A/POLR2G/POLR2E/POLR2J3/POLR1D/POLR1A/POLR2B/POLR3GL/POLR1C/POLR3K	2.71734326412825
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	19/2056	51/9376	1.69893949797818	PRKCA/SEC61B/ATP6V1F/ATP6V1G1/SEC61G/PRKACB/ATP6V1D/ATP6V0A1/ATP6V1B2/KCNQ1/ATP6V0B/ATP6V0D1/PRKACA/ATP6V1C1/ACTG1/ATP6V1A/ATP6V1H/TCIRG1/PLCG1	2.65241762053101
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	41/2056	133/9376	1.405810245458	TYROBP/FCGR3A/FCER1G/HCST/HLA-C/HLA-A/LCP2/PRKCB/PRKCA/SYK/ICAM1/ITGB2/BID/NFATC2/SH3BP2/PPP3R1/VAV1/RAC2/MAP2K2/PIK3CD/GRB2/SOS1/BRAF/ICAM2/TNFRSF10B/PIK3R3/PPP3CB/TNF/CD247/ITGAL/GZMB/LAT2/CD48/KRAS/PTPN6/HRAS/PRF1/SHC1/PLCG1/MICB/TNFRSF10A	2.49795151341771
Human Diseases	Cancer: specific types	hsa05218	Melanoma	25/2056	73/9376	1.56175043974202	HGF/CDK6/PDGFC/IGF1/CCND1/RB1/FGF7/MAP2K2/PIK3CD/BAX/BRAF/PIK3R3/MITF/TP53/POLK/CDK4/AKT1/KRAS/HRAS/AKT2/CDKN2A/DDB2/E2F3/PDGFRB/FGF2	2.55349489224885
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	37/2056	119/9376	1.41791191184645	CCL2/JUN/VCAM1/JUNB/MAP3K8/NFKB1/TNFRSF1B/CREB1/ICAM1/TNFRSF1A/SOCS3/PIK3CD/IRF1/MAP3K5/TAB2/CYLD/CCL5/PIK3R3/IL1B/RIPK1/CSF1/TNF/VEGFC/MAP3K7/AKT1/MAP3K14/CASP10/RHBDF2/AKT2/CXCL1/TAB3/CREB3L1/BIRC2/MAPK13/MAPK10/IKBKB/MAP2K6	2.43144668876663
NA	NA	hsa04518	Integrin signaling	46/2056	154/9376	1.36217090302693	SPP1/LAMA2/COL1A1/HGF/COL1A2/CCND2/COL6A1/COL6A2/VCAM1/PDGFC/IGF1/FREM1/CCND1/LAMA4/TNXB/ITGB5/ICAM1/ITGB2/FERMT3/ITGAM/LAMB2/RAC2/PIK3CD/NCK2/ICAM2/LAMC1/TLN1/PIK3R3/ITGAE/LAMC3/ACTG1/ITGA4/VEGFC/ITGAL/KDR/AKT1/PARVB/VTN/ICAM3/AKT2/ITGB4/PARVG/PDGFRB/COL6A6/ITGAX/ITGAD	2.4016129144
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	47/2056	158/9376	1.35654829335566	CCND2/CDK6/CCND1/RB1/YWHAB/YWHAH/ANAPC11/RBX1/ATM/PCNA/ATRX/HDAC8/CDC27/ATR/PPP2R5C/PPP2CB/CREBBP/HDAC2/TP53/ABL1/CDC16/MCM5/SKP2/BUB3/CDK4/ANAPC15/TFDP1/ORC4/ANAPC10/PTTG1/CDKN2A/ANAPC7/MAD1L1/CDC25B/E2F3/CHEK2/CDKN1B/PPP2R5B/CDKN2D/ORC5/CCNB2/TGFB3/CDK1/MCM3/RBL1/CDC7/MCM7	2.39535676462278
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	30/2056	93/9376	1.47106815614409	LAMA2/CDK6/CCND1/NFKB1/RB1/RARB/LAMA4/LAMB2/PIK3CD/FHIT/BAX/CYCS/MAX/LAMC1/CKS2/PIK3R3/TP53/POLK/LAMC3/SKP2/CDK4/AKT1/BCL2L1/APAF1/AKT2/DDB2/E2F3/CDKN1B/BIRC2/IKBKB	2.41948369167951
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	90/2056	333/9376	1.23251656325586	SPP1/LAMA2/COL1A1/WNT2/COL1A2/CCND2/COL6A1/COL6A2/MAGI1/CDK6/HLA-C/RBPJ/HLA-A/CCND1/NFKB1/RB1/LAMA4/CREB1/TNXB/ITGB5/ATP6V1F/ATP6V1G1/TNFRSF1A/PRKACB/ATP6V1D/MAML2/ATM/LAMB2/ATP6V0A1/MAP2K2/ATP6V1B2/PIK3CD/EIF4EBP1/GRB2/SOS1/IRF1/BAX/ATR/PTGER4/ATP6V0B/PPP2R5C/ATP6V0D1/LAMC1/APC/PPP2CB/CREBBP/PIK3R3/HDAC2/PRKACA/TP53/LAMC3/ATP6V1C1/ITGA4/TNF/ATP6V1A/WNT2B/TCF7/CDK4/PPP2R3C/AKT1/KRAS/HES4/ATP6V1H/HRAS/VTN/RPS6KB2/TCIRG1/AKT2/NOTCH3/ITGB4/HLA-F/NOTCH1/FZD2/LFNG/TADA3/RFNG/TBPL1/TUBG2/CDKN1B/PPP2R5B/IRF9/CREB3L1/PDGFRB/COL6A6/TUBG1/FZD5/IKBKB/RBL1/FZD7/DVL2	2.28960939962199
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	25/2056	75/9376	1.5201037613489	PMAIP1/BID/ATM/MGST2/GSTO1/PIK3CD/MAP3K5/BAX/CYCS/REV3L/MSH3/PIK3R3/TOP2A/TP53/XPA/AKT1/GSTA4/BCL2L1/MSH6/APAF1/AKT2/CDKN2A/ATP7A/MLH1/BIRC2	2.39661049558047
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	52/2056	180/9376	1.31742325983571	CCL2/HLA-C/CD74/HLA-A/HLA-DRA/NFKB1/POU2F2/HLA-DPA1/SYK/BID/HLA-DQA2/SRSF3/PPP1CB/TNFRSF1A/SOCS3/HLA-DMA/PIK3CD/EIF4EBP1/BAX/CYCS/TAB2/EIF2S1/PPP1CA/CCL5/HLA-DMB/PIK3R3/IL1B/TP53/TLR2/TNFRSF14/TNF/SRSF6/PPP1CC/SRSF1/EIF2B3/MAP3K7/AKT1/CGAS/SRSF8/BCL2L1/DAXX/APAF1/AKT2/HLA-F/HCFC1/IRAK4/HCFC2/IRF9/BIRC2/PILRA/IKBKB/EIF2B2	2.27885751294323
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	40/2056	133/9376	1.37152219069073	CCND2/IGF1/KLF2/CCND1/HOMER3/GABARAP/PRMT1/GABARAPL2/ATM/NLK/TGFBR1/MAP2K2/PIK3CD/STAT3/GRB2/SOS1/BRAF/SGK3/STK4/CAT/CREBBP/PIK3R3/SIRT1/SKP2/STK11/SETD7/AKT1/KRAS/HRAS/AKT2/S1PR1/CDKN1B/PCK2/CDKN2D/MAPK13/MAPK10/IRS1/CCNB2/TGFB3/IKBKB	2.28689252893746
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	19/2056	54/9376	1.60455397031273	LDHB/BCAT1/MDH1/APIP/DNMT3A/MDH2/CISD1/MAT2A/AHCY/AHCYL2/GCLM/KYAT3/LACC1/MTR/SDSL/GSS/PHGDH/GOT1/SDS	2.36112544312857
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	24/2056	73/9376	1.49928042215234	CD4/SERINC5/FEZ1/BICD1/CHMP4A/PPIA/RAN/PSIP1/APOBEC3C/RANBP2/XPO1/PIN1/CREBBP/CPSF6/NELFCD/BICD2/KAT2B/CPSF7/CCNT1/CHMP6/MLLT1/MAP1S/NELFA/APOBEC3G	2.26953094749929
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	49/2056	170/9376	1.31444266422522	WNT2/HGF/CDK6/PRKCB/PRKCA/CCND1/RB1/MGST2/LRP6/TGFBR1/GSTO1/MAP2K2/PIK3CD/GRB2/SOS1/BAX/BRAF/NFE2L2/ARID1A/APC/SMARCA2/PIK3R3/TP53/POLK/LEF1/ACTG1/WNT2B/TCF7/CDK4/AKT1/KRAS/HRAS/GSTA4/RPS6KB2/BCL2L1/ACTL6A/AKT2/CDKN2A/SHC1/FZD2/DDB2/E2F3/KEAP1/TGFB3/PLCG1/TGFA/FZD5/FZD7/DVL2	2.19266404707902
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	23/2056	70/9376	1.49838799332963	HGF/JUN/HIF1A/ELOB/ELOC/RBX1/MAP2K2/PIK3CD/GRB2/SOS1/BRAF/CREBBP/PIK3R3/ETS1/FH/AKT1/KRAS/HRAS/AKT2/EGLN2/TFE3/TGFB3/TGFA	2.21807751800184
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	35/2056	116/9376	1.37595599087616	GNG2/GNG11/PLD1/PRKCB/GNAI2/PRKCA/PLCB1/SLC1A6/GNGT1/GNG5/ITPR2/HOMER3/GNG10/PPP3R1/GNB4/PRKACB/DLGAP1/GRK2/GNAI3/GNB1/GNAQ/GLS/GNB2/GRIA4/PRKACA/PPP3CB/PLCB2/ITPR1/TRPC1/GRIN2C/GNG7/PLA2G4C/SLC1A1/DLG4/ADCY4	2.15924619928982
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	56/2056	200/9376	1.27688715953307	JUN/TUBA1B/CXCL8/FCGR2A/PYCARD/ARPC3/NFKB1/WASF2/TUBA1A/MYO5A/CYTH4/ARPC5/TLR4/NCKAP1L/MYO1F/NLRP3/CLDN5/TNFRSF1A/CASP1/BRK1/WIPF1/GNA13/NCK2/BAX/ACTR2/ROCK1/CYCS/TNFRSF10B/MYH10/MYO1B/ARPC4/TAB2/CYFIP1/IL1B/ABL1/RIPK1/TUBB2A/LPAR5/ACTG1/TNF/WIPF2/MAP3K7/PTPN6/NAIP/CYTH2/CASP4/TLR5/IRAK4/NFKBIB/TAB3/MAPK13/MAPK10/ARHGEF1/IKBKB/CLDN11/TNFRSF10A	2.09764873405172
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	12/2056	31/9376	1.76528178737291	MDH1/MDH2/CAT/ACO2/GRHPR/PGP/DLD/ACSS1/AFMID/ACAT1/ACSS2/SHMT2	2.261800130278
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	19/2056	56/9376	1.54724847137299	CD14/CR1/CXCL8/PYCARD/HSPA1A/NFKB1/TLR4/ITGB2/ITGAM/CASP1/CYCS/IL1B/TLR2/TNF/APAF1/NAIP/TLR5/CXCL1/HSPA6	2.17676861599164
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	27/2056	86/9376	1.43172563568908	AREG/JUN/PRKCB/PRKCA/CAMK2D/MAP2K2/PIK3CD/EIF4EBP1/NCK2/GRB2/SOS1/BRAF/PIK3R3/ABL1/ABL2/AKT1/KRAS/HRAS/RPS6KB2/AKT2/HBEGF/SHC1/CDKN1B/STAT5A/MAPK10/PLCG1/TGFA	2.13152710252767
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	11/2056	28/9376	1.79155086158977	ATP6V1F/ATP6V1G1/ATP6V1D/ATP6V0A1/ATP6V1B2/ATP6V0D1/ATP6V1C1/SLC12A7/ATP6V1A/SLC4A1/TCIRG1	2.2230034801686
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	15/2056	42/9376	1.62868260144525	KYNU/ECHS1/CAT/IDO2/HAAO/ALDH9A1/KYAT3/DLD/HADH/AFMID/IDO1/ALDH7A1/ACAT1/ALDH3A2/INMT	2.16403281146013
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	36/2056	122/9376	1.34566562480066	IGF1/JUNB/PRKCB/GNAI2/PRKCA/PLCB1/ITPR2/CREB1/MAP3K1/PRKACB/MAP2K2/SOCS3/PIK3CD/STAT3/GRB2/SOS1/GNAI3/GNAQ/CREBBP/PIK3R3/PRKACA/PLCB2/ITPR1/AKT1/KRAS/HRAS/AKT2/SHC1/STAT5A/CREB3L1/MAPK13/MAPK10/IRS1/PLCG1/ADCY4/MAP2K6	2.03663411049351
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	21/2056	65/9376	1.47333133792278	SPP1/PRKCB/PRKCA/PLCB1/ITPR2/KISS1/ARRB2/MAP2K2/PIK3CD/ARRB1/GNAQ/KCNJ5/CGA/PIK3R3/PLCB2/ITPR1/TRPC1/AKT1/KRAS/HRAS/AKT2	2.02938958240611
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	94/2056	362/9376	1.18416922845411	SPP1/LAMA2/GNG2/COL1A1/HGF/COL1A2/CCND2/COL6A1/COL6A2/AREG/MAGI1/CDK6/LPAR6/GNG11/PDGFC/IGF1/PRKCA/CCND1/NFKB1/GNGT1/GNG5/FGF7/LAMA4/GNG10/SYK/YWHAB/CREB1/YWHAH/TNXB/TLR4/PIK3AP1/ITGB5/RPS6/PKN2/KITLG/ANGPT1/GNB4/CSF1R/LAMB2/MAP2K2/PIK3CD/EIF4EBP1/EIF4E/GRB2/SOS1/PIK3CG/JAK3/GNB1/PIK3R5/GNB2/PPP2R5C/SGK3/PKN1/LAMC1/EFNA5/PPP2CB/PIK3R3/TP53/TLR2/LPAR5/LAMC3/ITGA4/CSF1/VEGFC/TEK/KDR/STK11/IL2RA/CDK4/PPP2R3C/IL6R/AKT1/KRAS/HRAS/VTN/RPS6KB2/BCL2L1/BDNF/AKT2/ITGB4/GNG7/FGFR3/CDKN1B/PPP2R5B/PCK2/CREB3L1/PDGFRB/COL6A6/IRS1/TGFA/OSMR/FGF2/IKBKB/IL2RG	1.89388772806053
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	45/2056	160/9376	1.28258754863813	HLA-C/VCAN/PTPRC/VCAM1/PTPRD/HLA-A/CADM3/HLA-DRA/PECAM1/CD86/CD4/HLA-DPA1/CD28/ICAM1/CD99/SIGLEC1/ITGB2/HLA-DQA2/MAG/CLDN5/ITGAM/ALCAM/HLA-DMA/PTPRM/GLG1/ICAM2/CDH5/NLGN4X/CD34/HLA-DMB/SDC2/ITGA4/ITGAL/CD58/ICAM3/JAM3/NEGR1/NCAM2/HLA-F/LRRC4/SLITRK4/NRCAM/SELPLG/CLDN11/NECTIN3	1.91066009466726
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	30/2056	101/9376	1.35454790615248	WNT2/CALM2/PRKCB/GNAI2/PRKCA/PLCB1/CALM3/CREB1/KITLG/PRKACB/CAMK2D/MAP2K2/GNAI3/GNAQ/CALML4/CREBBP/MITF/PRKACA/LEF1/PLCB2/WNT2B/TCF7/KRAS/HRAS/FZD2/CREB3L1/FZD5/ADCY4/FZD7/DVL2	1.89854242117423
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	31/2056	105/9376	1.34637761719474	RPS27A/UBA52/UBB/JUN/TOMM7/HIF1A/GABARAP/RAB5C/SMURF2/USP15/GABARAPL2/PRKN/ARIH1/TOMM20/EIF2S1/OPA1/CSNK2A1/MTX2/MITF/TP53/RHOT1/KRAS/HRAS/PHB2/BCL2L1/FUNDC1/RHOT2/TFEB/MAPK10/TFE3/SAMM50	1.89157180562211
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	15/2056	44/9376	1.55465157410683	HMGB1/PCNA/PARP1/APEX1/POLD4/POLE4/MPG/POLD2/RFC4/POLE/PARG/POLE3/RFC2/NEIL2/MUTYH	1.95434339723865
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	15/2056	44/9376	1.55465157410683	HLA-C/HLA-A/HLA-DRA/CD86/HLA-DPA1/CD28/HLA-DQA2/ICA1/HLA-DMA/HLA-DMB/IL1B/TNF/GZMB/PRF1/HLA-F	1.95434339723865
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	19/2056	59/9376	1.46857482028622	CCND1/MAP2K2/PIK3CD/GRB2/SOS1/BAX/BRAF/APC/PIK3R3/TP53/POLK/LEF1/TCF7/AKT1/KRAS/HRAS/AKT2/DDB2/MLH1	1.91341228583759
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	13/2056	37/9376	1.60227153223262	CCND1/NCOA4/TPM3/MAP2K2/BAX/BRAF/TP53/POLK/LEF1/TCF7/KRAS/HRAS/DDB2	1.94529138239687
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	62/2056	232/9376	1.21870387763317	TMSB4X/PDGFC/ARPC3/WASF2/FGF7/MSN/ARPC5/ITGB5/NCKAP1L/PFN1/ITGB2/PPP1CB/ENAH/VAV1/ITGAM/BRK1/GNA13/RAC2/MAP2K2/MYL12A/PIK3CD/SOS1/BRAF/ACTR2/ROCK1/MYH10/ARPC4/IQGAP2/CYFIP1/PPP1CA/APC/PIK3R3/PIKFYVE/ITGAE/ABI2/GIT1/LPAR5/SCIN/ACTG1/ITGA4/ITGAL/PPP1CC/CXCL12/ARHGAP35/MYLK/AKT1/KRAS/HRAS/SPATA13/AKT2/ITGB4/LIMK1/PFN2/FGFR3/PDGFRB/ARHGEF1/PIP4K2B/ITGAX/FGF2/FGD3/ITGAD/C9	1.78761512167078
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	11/2056	30/9376	1.67211413748379	MDH1/MDH2/OGDH/FH/ACO2/PDHB/SDHD/SUCLG1/DLD/PCK2/IDH3B	1.95403537822133
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	22/2056	71/9376	1.41305420069052	CCND2/CCND1/NFKB1/MAP2K2/SOCS3/PIK3CD/STAT3/GRB2/SOS1/IRF1/TNFRSF11A/CGA/PIK3R3/AKT1/KRAS/HRAS/AKT2/SHC1/STAT5A/MAPK13/MAPK10/GALT	1.85148279917655
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	18/2056	56/9376	1.46581434130072	CCND2/DISP1/CCND1/ARRB2/SMURF2/PRKACB/GRK2/ARRB1/GAS1/FBXW11/PRKACA/SPOP/SPOPL/SUFU/MEGF8/GLI2/CDON/PTCH1	1.8528512952778
Human Diseases	Substance dependence	hsa05032	Morphine addiction	27/2056	91/9376	1.3530593919699	GNG2/PDE4D/GNG11/PRKCB/GNAI2/PRKCA/PDE4B/GNGT1/GNG5/GNG10/ARRB2/PDE3A/GNB4/PRKACB/GRK2/ARRB1/GNAI3/GNB1/KCNJ5/GNB2/PDE3B/PRKACA/PDE7A/GABRA3/GNG7/PDE1C/ADCY4	1.79357343924738
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	19/2056	60/9376	1.44409857328145	PRKCB/PRKCA/NFATC2/PPP3R1/RAC2/MAP2K2/PIK3CD/PIK3R3/PPP3CB/KDR/MAPKAPK3/AKT1/KRAS/HRAS/AKT2/PLA2G4C/SPHK1/MAPK13/PLCG1	1.82886612600209
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	33/2056	115/9376	1.30861106411775	GNG2/GNG11/PRKCB/GNAI2/PRKCA/PLCB1/GNGT1/GNG5/ITPR2/GNG10/CREB1/GNB4/PRKACB/CAMK2D/KCNQ1/PIK3CD/PIK3CG/GNAI3/GNB1/GNAQ/PIK3R5/GNB2/PIK3R3/PRKACA/PLCB2/ITPR1/AKT1/KRAS/HRAS/AKT2/GNG7/CREB3L1/ADCY4	1.76470909084067
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	55/2056	205/9376	1.22349814937838	CCND2/HDAC9/CDK6/HLA-C/JUN/RBPJ/HLA-A/LYN/CCND1/NFKB1/RB1/SYK/YWHAB/CREB1/YWHAH/PMAIP1/GTF2B/EGR2/PRKACB/REL/GTF2A2/PIK3CD/VDAC3/STAT3/GRB2/HDAC8/BAX/JAK3/RANBP1/RASA2/ATP6V0D1/CREBBP/PIK3R3/HDAC2/PRKACA/TP53/SCIN/HDAC7/SKP2/CDK4/KRAS/HRAS/KAT2B/EGR3/GTF2H3/HLA-F/CDKN2A/MAD1L1/TBPL1/CDKN1B/STAT5A/IRF9/CREB3L1/CDK1/RBL1	1.71468428684791
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	13/2056	38/9376	1.56010649191071	ENPP1/NAMPT/NT5C/NNT/CD38/SIRT1/NAPRT/PNP/SIRT2/SIRT3/NADK2/BST1/NUDT12	1.83348399286696
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	17/2056	53/9376	1.46274135526026	ATP1B3/CLTC/ATP1B1/ATP2B1/PRKCB/PRKCA/PLCB1/CLTA/SLC8A1/AP2S1/PRKACB/RAB11A/GNAQ/AP2M1/PRKACA/PLCB2/KL	1.79035873595779
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	33/2056	116/9376	1.29732993425466	PGLS/ME2/ESD/ME1/HIBCH/MDH1/GLUD1/ECHS1/TKT/MDH2/CAT/OGDH/GPI/FH/ACO2/PDHB/SDHD/SUCLG1/PGP/SDSL/DLD/ACSS1/ADPGK/PRPS1/PHGDH/GOT1/ACAT1/ACSS2/PRPS2/SDS/RPIA/SHMT2/IDH3B	1.70766937103007
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	11/2056	31/9376	1.6181749717585	SRP14/SEC61B/SEC61G/SRP9/SPCS1/SEC11A/SPCS3/TMEM208/OXA1L/SEC11C/GET3	1.82702405143828
NA	NA	hsa04981	Folate transport and metabolism	11/2056	31/9376	1.6181749717585	FOLR2/SLCO2B1/ABCC5/MTHFR/ABCG2/MTR/TYMS/ABCC4/SLC46A1/MTHFS/SHMT2	1.82702405143828
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	14/2056	42/9376	1.5201037613489	FTL/CYBB/SLC40A1/GPX4/NCOA4/ATG7/SAT2/VDAC3/PRNP/VDAC2/TP53/GCLM/ACSL5/GSS	1.79028591269336
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	31/2056	109/9376	1.29696926427016	RUNX1/JUN/HLA-DRA/HIF1A/NFKB1/CD4/HLA-DPA1/NFATC2/HLA-DQA2/PPP3R1/TGFBR1/HLA-DMA/STAT3/RORA/JAK3/NFATC3/HLA-DMB/IL1B/PPP3CB/CD247/AHR/IL2RA/IL6R/NFKBIE/STAT5A/NFKBIB/MAPK13/MAPK10/PLCG1/IKBKB/IL2RG	1.65271064101801
Organismal Systems	Digestive system	hsa04970	Salivary secretion	27/2056	93/9376	1.32396134052969	CST3/PRKG1/ATP1B3/CALM2/ATP1B1/ATP2B1/PRKCB/PRKCA/PLCB1/LYZ/GUCY1A2/ITPR2/CALM3/GUCY1A1/PRKACB/VAMP2/GNAQ/ADRB1/CALML4/CD38/PRKACA/PLCB2/PRH1/ITPR1/GUCY1B1/BST1/ADCY4	1.66391884045425
Human Diseases	Immune disease	hsa05330	Allograft rejection	13/2056	39/9376	1.5201037613489	HLA-C/HLA-A/HLA-DRA/CD86/HLA-DPA1/CD28/HLA-DQA2/HLA-DMA/HLA-DMB/TNF/GZMB/PRF1/HLA-F	1.72488550056329
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	8/2056	21/9376	1.7372614415416	CSGALNACT2/CHSY3/CSGALNACT1/B3GAT3/DSEL/CHSY1/CHST12/B3GALT6	1.79246599490081
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	8/2056	21/9376	1.7372614415416	ENPP1/DPYD/BCAT1/PPCDC/VNN2/AASDHPPT/ALDH3A2/CSAD	1.79246599490081
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	34/2056	122/9376	1.27090642342285	SLC16A10/ATP1B3/ATP1B1/PRKCB/PRKCA/PLCB1/CCND1/HIF1A/BMP4/PRKACB/MAP2K2/PIK3CD/TBC1D4/CREBBP/PIK3R3/HDAC2/MED30/PRKACA/TP53/PLCB2/ACTG1/GATA4/AKT1/KRAS/HRAS/KAT2B/AKT2/NOTCH3/MED1/NOTCH1/PFKFB2/THRA/PLCG1/PLCE1	1.59615889781619
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	31/2056	110/9376	1.28517863459498	CYBB/IGF1/PRKCB/MKNK1/PRKCA/LDHB/HIF1A/NFKB1/ELOB/TLR4/ELOC/RPS6/RBX1/ANGPT1/CAMK2D/MAP2K2/PIK3CD/EIF4EBP1/STAT3/EIF4E/CREBBP/PIK3R3/PDHB/TEK/IL6R/AKT1/RPS6KB2/AKT2/EGLN2/CDKN1B/PLCG1	1.59444239280574
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	31/2056	110/9376	1.28517863459498	DCN/BMP5/PITX2/BMP4/EMP3/RBX1/ACVR2A/SMURF2/SMAD5/BAMBI/TGFBR1/ZFYVE16/ID2/ROCK1/FMOD/SMAD6/THSD4/PPP2CB/CREBBP/HDAC2/NBL1/TNF/NRROS/BMPR1A/TFDP1/RPS6KB2/LRRC32/GDF6/TGFB3/RBL1/SMAD1	1.59444239280574
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	30/2056	106/9376	1.29065413699435	FOLR2/PDGFC/IGF1/CCND1/NFKB1/RB1/ETV5/CREB1/PLAU/MAP2K2/PIK3CD/GRB2/SOS1/BRAF/CREBBP/PIK3R3/TP53/LEF1/TCF7/AKT1/KRAS/HRAS/AKT2/SLC46A1/E2F3/CDKN1B/CREB3L1/PDGFRB/TGFA/IKBKB	1.59489180752605
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	11/2056	32/9376	1.56760700389105	LDHB/HIBCH/ECHS1/ECHDC1/ACSS3/ACACA/SUCLG1/DLD/ACSS1/ABAT/ACSS2	1.70450379628486
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	28/2056	98/9376	1.3029460811562	CALM2/PRKCB/PRKCA/PLCB1/ITPR2/CALM3/INPP5D/PIK3CD/PPIP5K2/CALML4/ITPKB/PIK3R3/INPP4A/PIKFYVE/PLCB2/SACM1L/SYNJ1/ITPR1/PI4K2A/PIK3C2B/PIP4P2/MTMR6/MTMR14/PI4KB/PIP4K2B/PLCG1/PI4K2B/PLCE1	1.59769120879165
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	26/2056	90/9376	1.31742325983571	IGF1/NFKB1/CREB1/PRKACB/PIK3CD/EIF4EBP1/EIF4E/BAX/CAT/PIK3R3/APPL1/PRKACA/TP53/SESN3/ADIPOR1/SIRT1/KL/STK11/AKT1/KRAS/HRAS/RPS6KB2/AKT2/CREB3L1/IRS1/ADCY4	1.60356775697859
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	32/2056	115/9376	1.26895618338691	MEF2C/PDE4D/EGR1/NR4A2/PLD1/PRKCB/NACA/GNAI2/PRKCA/PLCB1/PDE4B/ITPR2/MEF2A/CREB1/ARRB2/PRKACB/LRP6/GNA13/ARRB1/GNAI3/BRAF/GNAQ/MAFB/PRKACA/PLCB2/ITPR1/KL/MEF2D/HBEGF/CREB3L1/ARHGEF1/ADCY4	1.53795335633072
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	28/2056	99/9376	1.28978500962937	CALM2/IGF1/PRKCB/PRKCA/PLCB1/ITPR2/HRH1/CALM3/PPP1CB/PRKACB/CAMK2D/PIK3CD/GNAQ/PTGER4/PPP1CA/CALML4/PIK3R3/IL1B/PRKACA/PLCB2/ITPR1/PPP1CC/PLA2G4C/MAPK13/MAPK10/PLCG1/ADCY4/MAP2K6	1.53614208611697
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	39/2056	144/9376	1.23508430609598	CD14/C1QA/C1QC/C1QB/LY96/CXCL8/C3AR1/CCND1/NFKB1/C2/TLR4/TNFRSF1A/MAP3K5/TAB2/IL1B/LEF1/RIPK1/ALDH9A1/TNF/IL17RA/ACACA/ADIPOR1/SIRT1/TCF7/MAP3K7/AKT1/MAP3K14/IL17RC/AKT2/FASN/ALDH7A1/CXCL1/IRAK4/TAB3/MAPK13/MAPK10/IKBKB/ALDH3A2/MAP2K6	1.50660234186871
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	45/2056	169/9376	1.21428406971658	RPS27A/UBA52/UBB/HMGB1/HIF1A/ATG7/WDFY3/GABARAP/TANK/PRKACB/UVRAG/GABARAPL2/VMP1/STX7/MAP2K2/PIK3CD/VAMP8/C9orf72/EIF2S1/ATG4C/PPP2CB/PIK3R3/PRKACA/RRAGA/ITPR1/DEPTOR/STK11/MAP3K7/ULK2/AKT1/KRAS/HRAS/MTMR14/RPS6KB2/BCL2L1/AKT2/RRAGB/PIK3R4/VPS16/VPS11/VPS33A/MAPK10/RUBCN/IRS1/SMCR8	1.4897583199332
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	53/2056	203/9376	1.19062314312549	SPP1/LAMA2/COL1A1/HGF/COL1A2/CCND2/COL6A1/COL6A2/JUN/PDGFC/IGF1/PRKCB/PRKCA/CCND1/ARHGAP5/LAMA4/TNXB/ITGB5/PPP1CB/VAV1/LAMB2/RAC2/MYL12A/PIK3CD/GRB2/SOS1/BRAF/ROCK1/PPP1CA/LAMC1/TLN1/PIK3R3/LAMC3/ACTG1/ITGA4/ZYX/VEGFC/PPP1CC/KDR/ARHGAP35/MYLK/AKT1/PARVB/HRAS/VTN/AKT2/ITGB4/PARVG/SHC1/PDGFRB/COL6A6/BIRC2/MAPK10	1.45515615712086
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	47/2056	178/9376	1.20412713679885	WNT2/SERPINF1/CCND2/JUN/RSPO2/PRICKLE1/PRKCB/PRKCA/PLCB1/CCND1/RSPO3/NFATC2/RBX1/PPP3R1/PRKACB/BAMBI/TLE4/LRP6/NLK/INVS/CAMK2D/RAC2/FRZB/NFATC3/FBXW11/APC/CREBBP/CSNK2A1/PRKACA/TP53/LEF1/PPP3CB/PLCB2/WNT2B/CBY1/SIRT1/ZNRF3/TCF7/MAP3K7/CTNNBIP1/SENP2/FZD2/DKK2/MAPK10/FZD5/FZD7/DVL2	1.45715481368135
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	22/2056	76/9376	1.32009010853983	ATP1B3/CALM2/ATP1B1/PRKCB/GNAI2/PRKCA/PLCB1/ITPR2/CALM3/PRKACB/CAMK2D/KCNQ1/GNAI3/GNAQ/HRH2/CALML4/PRKACA/PLCB2/ACTG1/ITPR1/MYLK/ADCY4	1.4848385297409
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	41/2056	154/9376	1.21410884835009	ATP1B3/RYR2/CALM2/CREM/ATP1B1/ATP2B1/GNAI2/PRKCA/PLCB1/CALM3/CREB1/SLC8A1/PPP1CB/PRKACB/CACNB4/TPM3/SCN1B/CAMK2D/KCNQ1/PIK3CG/GNAI3/GNAQ/PIK3R5/PPP2R5C/ADRB1/PPP1CA/CALML4/PPP2CB/PRKACA/PLCB2/PPP1CC/PPP2R3C/AKT1/CACNA2D1/AGTR1/AKT2/CACNA2D4/PPP2R5B/CREB3L1/MAPK13/ADCY4	1.41978985884091
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	14/2056	45/9376	1.4187635105923	HLA-C/HLA-A/HLA-DRA/CD86/HLA-DPA1/CD28/HLA-DQA2/HLA-DMA/HLA-DMB/IL1B/TNF/GZMB/PRF1/HLA-F	1.49228800088135
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	37/2056	138/9376	1.22269215586759	CALM2/MKNK1/CALM3/RPS6/PRKAR1A/PPP1CB/PRKACB/FLOT1/MAP2K2/SOCS3/PIK3CD/EIF4EBP1/EIF4E/GRB2/SOS1/BRAF/PDE3B/PYGL/PTPN1/PPP1CA/CALML4/PIK3R3/PRKACA/ACACA/PPP1CC/EXOC7/AKT1/KRAS/HRAS/RPS6KB2/AKT2/FASN/SHC1/PCK2/MAPK10/IRS1/IKBKB	1.39668071558486
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	17/2056	57/9376	1.36009283910165	ELOVL2/HACD4/HADHB/CBR4/HACD3/HSD17B4/ECHS1/ACAA1/HSD17B12/ACACA/ACAA2/ACSL5/FADS2/HADH/FASN/ACAT1/ACSF3	1.44513663164803
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	20/2056	69/9376	1.32182935769469	CALM2/JUN/PRKCB/PRKCA/CALM3/CREB1/PPP3R1/PPP1CB/PRKACB/CAMK2D/GRIA4/PPP1CA/CALML4/HDAC2/PRKACA/PPP3CB/SIRT1/PPP1CC/GRIN2C/CREB3L1	1.42195875562766
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	39/2056	148/9376	1.20170364917447	WNT2/CDK6/JUN/IGF1/CCND1/RB1/FGF7/LRP6/MAP2K2/PIK3CD/GRB2/SOS1/BAX/BRAF/APC/PIK3R3/TP53/POLK/LEF1/WNT2B/TCF7/CDK4/AKT1/KRAS/HRAS/RPS6KB2/AKT2/NOTCH3/NOTCH1/SHC1/FZD2/DDB2/E2F3/DLL4/JAG2/FZD5/FGF2/FZD7/DVL2	1.31078804886931
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	22/2056	78/9376	1.2862416442183	PLCB1/INPP5D/PIK3CD/PIK3CG/PPIP5K2/ITPKB/INPP4A/PIKFYVE/PLCB2/SACM1L/SYNJ1/PI4K2A/FIG4/PIK3C2B/MTMR6/MTMR14/PI4KB/ISYNA1/PIP4K2B/PLCG1/PI4K2B/PLCE1	1.34532434462892
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	20/2056	70/9376	1.3029460811562	CD36/NFKB1/TNFRSF1B/TNFRSF1A/SOCS3/STAT3/APPL1/TNF/ADIPOR1/STK11/AKT1/ACSL5/AKT2/NFKBIE/LEPR/NFKBIB/PCK2/MAPK10/IRS1/IKBKB	1.34826260016842
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	50/2056	195/9376	1.169310585653	CYBA/FCGR3A/CYBB/CR1/HDAC9/FCGR1A/PRKCB/FCGR2A/NCF4/PRKCA/CLEC7A/PLCB1/HMGB1/NFKB1/ATG7/SLC25A6/SLC25A5/SYK/TLR4/CLCN5/ITGB2/FPR1/ITGAM/NCF1/CASP1/RAC2/MAP2K2/PIK3CD/VDAC3/HDAC8/TLR7/NCF2/VDAC2/PIK3R3/HDAC2/TLR2/PLCB2/ACTG1/HDAC7/CLCN3/ITGAL/MAP3K7/AKT1/AKT2/CASP4/TLR8/MAPK13/SELPLG/PLCG1/CLCN4	1.26618766033417
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	10/2056	31/9376	1.47106815614409	DPYD/HIBCH/CNDP2/ECHS1/ALDH9A1/SMOX/ALDH7A1/ABAT/ALDH3A2/CSAD	1.39224797259855
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	27/2056	99/9376	1.24372125928546	C1QA/FCGR3A/CFD/C1QC/C1QB/FCGR1A/FCGR2A/C3AR1/HLA-DRA/C1R/HLA-DPA1/C2/ICAM1/ITGB2/FPR1/HLA-DQA2/KRT10/ITGAM/HLA-DMA/PTAFR/HLA-DMB/ITGAL/KRT24/CFI/SELPLG/C1S/FCGR2B	1.29195945693901
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	12/2056	39/9376	1.4031727027836	MTHFR/MAT2A/AHCY/AHCYL2/MTR/DLD/TYMS/ALDH7A1/MTHFS/GART/SHMT2/MTHFD2L	1.33709232836682
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	27/2056	100/9376	1.23128404669261	CCL3/CXCL14/CCL2/CCL4/CCL4L2/CCL3L1/CXCL8/CCL8/TNFRSF1B/CSF1R/TNFRSF1A/IL10RA/CX3CR1/TNFRSF10B/CCR1/IL10RB/CCL5/TNFRSF14/CSF1/TNF/CCL13/CXCL12/IL2RA/IL6R/CXCL1/IL2RG/TNFRSF10A	1.23227307772808
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	29/2056	109/9376	1.21329382786563	CD36/PRKCB/SLC27A4/NFKB1/CREB1/PPP1CB/TNFRSF1A/SOCS3/PIK3CD/STAT3/TBC1D4/RPS6KA3/PYGL/PTPN1/PPP1CA/PIK3R3/MLXIP/TNF/PPP1CC/AKT1/RPS6KB2/AKT2/PCK2/MLX/CREB3L1/SLC27A3/MAPK10/IRS1/IKBKB	1.18703523020587
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	10/2056	32/9376	1.42509727626459	PMAIP1/BID/TNFRSF1A/BAX/CYCS/BCL2L1/APAF1/HTRA2/BIRC2/MAPK10	1.27655211478403
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	13/2056	44/9376	1.34736469755925	DYNLL1/CREB1/RAB5C/PRKACB/DCTN4/VAMP2/RAB11A/PRKACA/DCTN6/DCTN2/DYNC2LI1/CREB3L1/DYNC2H1	1.22395740821961
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	25/2056	93/9376	1.22589013012008	PTPRJ/WASF2/LMO7/WAS/SMURF2/NLK/TGFBR1/RAC2/MYL12A/PTPRM/ROCK1/CDH5/CCM2/PTPRB/PTPN1/ARHGAP29/CREBBP/CSNK2A1/LEF1/ACTG1/FARP2/TCF7/MAP3K7/PTPN6/NECTIN3	1.16020893963742
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	9/2056	29/9376	1.4152690191869	RASSF4/MOB1A/LATS1/RASSF2/NF2/RASSF1/MOB1B/DCHS1/TEAD2	1.18695447614755
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	22/2056	82/9376	1.22349814937838	NME2/DPYD/NME3/MGST2/TYMP/GSTO1/IMPDH2/DUT/NME1/RRM1/ITPA/NME4/TK2/HPRT1/NME6/GMPS/GSTA4/IMPDH1/NAT1/TPMT/RRM2B/UCK1	1.07726159275467
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	26/2056	99/9376	1.19765750894156	JUN/PDGFC/PLD1/PRKCB/PRKCA/HIF1A/WASF2/WAS/RAC2/MAP2K2/PLPP3/PIK3CD/EIF4EBP1/GRB2/SOS1/PIK3R3/CHKB/AKT1/KRAS/HRAS/RPS6KB2/AKT2/PLA2G4C/PDGFRB/MAPK10/PLCG1	1.04777682776105
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	18/2056	66/9376	1.24372125928546	MAF/JUN/IL12RB2/HLA-DRA/NFKB1/HLA-DPA1/TLR4/HLA-DQA2/HLA-DMA/STAT3/RORA/HLA-DMB/IL1B/TLR2/TNF/TLR5/TGFB3/IL2RG	1.0530092677834
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	17/2056	62/9376	1.25040793272248	IGF1/HSPA1A/PRKACB/PIK3CD/CAT/PIK3R3/HDAC2/PRKACA/SIRT1/AKT1/KRAS/HRAS/RPS6KB2/AKT2/HSPA6/IRS1/ADCY4	1.04837694956174
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	39/2056	155/9376	1.14743316179239	WNT2/CDK6/GNAI2/PLCB1/CCND1/RB1/ITPR2/CREB1/PRKACB/CAMK2D/MAP2K2/GNAI3/BRAF/GNAQ/APC/PRKACA/LEF1/PLCB2/FH/ITPR1/WNT2B/AIP/AHR/KMT2D/TCF7/CDK4/AGTR1/ASH2L/CDKN2A/FZD2/PBX1/E2F3/CDKN1B/CREB3L1/RBBP5/FZD5/ADCY4/FZD7/DVL2	0.980875010457854
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	22/2056	83/9376	1.20875720781961	HMGCLL1/FAR1/PMVK/HSD17B4/NUDT19/CAT/ACAA1/PEX2/ACSL5/PHYH/PEX16/MPV17/AMACR/PEX10/GNPAT/HACL1/PXMP2/PXMP4/ECI2/ABCD4/NUDT12/PEX6	1.01238152213726
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	22/2056	83/9376	1.20875720781961	CCL4/CCL4L2/IFI16/PYCARD/NFKB1/POLR2L/NLRP3/CASP1/POLR2K/POLR2E/CCL5/G3BP1/POLR1D/IL1B/IL33/RIPK1/CGAS/POLR3GL/POLR1C/NFKBIB/POLR3K/IKBKB	1.01238152213726
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	35/2056	138/9376	1.15660068798286	CALM2/IGF1/ITPR2/YWHAB/CALM3/YWHAH/ANAPC11/RBX1/CPEB4/PPP3R1/PPP1CB/PRKACB/CAMK2D/CDC27/FBXW11/RPS6KA3/PPP2R5C/PPP1CA/CALML4/PPP2CB/PRKACA/PPP3CB/CDC16/ITPR1/PPP1CC/ANAPC15/ANAPC10/PTTG1/ANAPC7/MAD1L1/PPP2R5B/MAPK13/CCNB2/CDK1/ADCY4	0.982168231749595
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	14/2056	50/9376	1.27688715953307	LAP3/SAT2/CNDP2/GATM/GAMT/ALDH9A1/OAT/ODC1/SMOX/ALDH7A1/GOT1/ARG2/ALDH3A2/PYCR2	1.04035549531285
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	26/2056	100/9376	1.18568093385214	CD14/CD36/CR1/FCGR1A/HLA-DRA/CD4/HLA-DPA1/HLA-DQA2/KITLG/CSF1R/ITGAM/CD37/HLA-DMA/CD34/HLA-DMB/CD38/IL1B/ITGA4/CSF1/TNF/CD33/IL2RA/IL6R/CD7/IL11RA/CD24	0.989301333599999
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	11/2056	38/9376	1.32009010853983	ATP1B3/IGF1/ATP1B1/PRKCB/PRKCA/NR3C2/PIK3CD/PIK3R3/KRAS/NEDD4L/IRS1	1.04780090707534
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	23/2056	88/9376	1.19189954014857	F13A1/C1QA/CFD/C1QC/C1QB/CR1/A2M/C3AR1/CLU/C1R/C2/VSIG4/PROS1/ITGB2/PLAUR/PLAU/ITGAM/C4BPB/VTN/CFI/C1S/ITGAX/C9	0.958508171244317
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	17/2056	63/9376	1.23056018775863	WNT2/BMP4/BAX/APC/TP53/POLK/LEF1/WNT2B/TCF7/SUFU/FZD2/DDB2/GLI2/FZD5/FZD7/DVL2/PTCH1	0.973086490494044
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	23/2056	89/9376	1.17850741048398	GNG2/GNG11/PRKCB/GNAI2/PRKCA/GNGT1/GNG5/GABARAP/GNG10/GNB4/PRKACB/GABARAPL2/GNAI3/GNB1/GLS/GNB2/PRKACA/GABRA3/GNG7/SLC12A5/ABAT/TRAK2/ADCY4	0.896716545992519
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	37/2056	149/9376	1.13242629201159	FCER1G/LPAR6/PDGFC/CXCL8/PLD1/PRKCA/PLCB1/CYTH4/SYK/KITLG/GNA13/MAP2K2/PLPP3/PIK3CD/GRB2/SOS1/GAB2/PIK3CG/PIK3R5/AGPAT3/PIK3R3/PLCB2/LPAR5/AGPAT2/AKT1/KRAS/HRAS/AGTR1/AKT2/CYTH2/SHC1/PLA2G4C/SPHK1/PDGFRB/PLCG1/AGPAT5/ADCY4	0.863532615669246
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	7/2056	23/9376	1.38792082557943	ATP1B3/ATP1B1/MDH1/GLS/GLUD1/AQP1/PCK2	0.987127382107635
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	38/2056	154/9376	1.12527161554399	NME2/AKR1A1/NME3/KYNU/BCAT1/MOCS2/MAT2A/NME1/CTPS2/AK1/IDO2/UROD/PPCDC/GGCX/GCLM/HAAO/NME4/AK6/NAPRT/NME6/UROS/DLD/AFMID/IDO1/GSS/RDH11/TPK1/AK3/AK9/FECH/FLAD1/NADK2/ALAS2/HMBS/ALDH3A2/SHMT2/MTHFD2L/COQ5	0.830696025505456
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	37/2056	150/9376	1.12487678339818	WNT2/HGF/CCND1/RB1/RARB/FGF7/LRP6/TGFBR1/MAP2K2/PIK3CD/GRB2/SOS1/BAX/BRAF/APC/PIK3R3/TP53/POLK/LEF1/WNT2B/TCF7/AKT1/KRAS/HRAS/RPS6KB2/AKT2/SHC1/FZD2/DDB2/MLH1/E2F3/CDKN1B/TGFB3/FZD5/FGF2/FZD7/DVL2	0.817075636207334
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	27/2056	107/9376	1.15073275391832	CALM2/PLCB1/LDHB/ITPR2/CALM3/CREB1/PPP3R1/PRKACB/PRMT1/CAMK2D/GNAQ/PDE3B/PYGL/CALML4/SIK2/CREBBP/PRKACA/PPP3CB/PLCB2/PDHB/ITPR1/ACACA/SIRT1/AKT1/AKT2/PCK2/CREB3L1	0.831045370399123
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	14/2056	52/9376	1.22777611493565	CD36/PLTP/APOE/MYLIP/APOC1/LRP1/VDAC3/TSPO/NPC1/LIPG/LIPA/VDAC2/STARD3/STARD3NL	0.872871620027596
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	12/2056	44/9376	1.24372125928546	GTF2I/GTF2H5/GTF2B/GTF2A2/TAF10/TAF2/TAF9/GTF2H3/TBPL1/TAF9B/ERCC2/TAF8	0.858764413710096
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	17/2056	65/9376	1.19269679736606	AKR1B1/AKR1A1/GK/PLPP3/LIPG/AGPAT3/ALDH9A1/LCLAT1/GLA/AGPAT2/GPAT2/ALDH7A1/MBOAT2/ABHD16A/AGPAT5/ALDH3A2/AGK	0.826179975435093
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	33/2056	134/9376	1.1230617341309	PRKG1/CALM2/PRKCB/PRKCA/PLCB1/GUCY1A2/ITPR2/CALM3/GUCY1A1/MYL6/RAMP2/PPP1CB/PRKACB/PPP1R14A/GNA13/MAP2K2/BRAF/GNAQ/ROCK1/MYH10/PPP1CA/CALML4/PRKACA/PLCB2/ITPR1/GUCY1B1/PPP1CC/MYLK/AGTR1/PLA2G4C/ARHGEF1/ACTA2/ADCY4	0.760385979751995
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	8/2056	28/9376	1.3029460811562	ELOVL2/HACD4/HADHB/HACD3/ECHS1/HSD17B12/ACAA2/HADH	0.850798382508349
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	4/2056	12/9376	1.5201037613489	CD209/NPC1/NCAM2/FCGR2B	0.955413927528392
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/2056	16/9376	1.42509727626459	ST3GAL1/A4GALT/GLA/ST3GAL2/B3GALNT1	0.90188682379197
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	34/2056	139/9376	1.11547182487473	MMP2/CALM2/JUN/GNAI2/PLCB1/HSPA1A/ITPR2/CALM3/CREB1/PRKACB/KRT10/MAP2K2/PIK3CD/GRB2/SOS1/GNAI3/GNAQ/KCNJ5/CALML4/PIK3R3/PRKACA/PLCB2/ITPR1/AKT1/KRAS/HRAS/KRT24/AKT2/HBEGF/SHC1/CREB3L1/HSPA6/TGFA/ADCY4	0.726874796438883
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	21/2056	83/9376	1.15381369837326	MBD5/MAX/UBE2D3/SCML1/CREBBP/UBE2D1/HDAC2/DCAF7/CBX6/ASXL2/CBX4/RNF2/TFDP1/SFMBT2/HCFC1/MBD6/FBRS/EED/BCOR/FOXK1/SCML2	0.745929435017369
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	20/2056	79/9376	1.15450918583461	SYT1/CLTC/SLC1A6/CLTA/ATP6V1F/ATP6V1G1/AP2S1/ATP6V1D/ATP6V0A1/ATP6V1B2/VAMP2/AP2M1/ATP6V0B/ATP6V0D1/ATP6V1C1/ATP6V1A/ATP6V1H/TCIRG1/STX2/SLC1A1	0.730866552266295
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	38/2056	157/9376	1.10376961015143	BMP5/WNT2/CCND2/AREG/CCND1/BMP4/YWHAB/YWHAH/ITGB2/PPP1CB/MOB1A/TGFBR1/ID2/FBXW11/PPP1CA/APC/PPP2CB/LEF1/ACTG1/WNT2B/PPP1CC/LATS1/TCF7/NF2/BMPR1A/RASSF1/MOB1B/FZD2/GLI2/BIRC2/DLG4/TEAD2/GDF6/TGFB3/FZD5/SMAD1/FZD7/DVL2	0.694895911874662
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	16/2056	62/9376	1.17685452491528	RBPJ/ATXN1/MAML2/TLE4/PSENEN/CREBBP/HDAC2/KAT2B/APH1B/NOTCH3/NOTCH1/LFNG/RFNG/DLL4/JAG2/DVL2	0.74043264257268
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	11/2056	41/9376	1.22349814937838	SSBP1/ATM/RPA3/RAD51B/BABAM2/POLD4/NBN/RPA2/POLD2/MUS81/BRCC3	0.760064329993516
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	44/2056	184/9376	1.09050922009812	NRP1/SLIT2/EPHA3/GNAI2/PRKCA/ROBO1/UNC5C/NFATC2/ROBO2/PPP3R1/EFNB2/ENAH/SEMA3D/CAMK2D/ABLIM3/RAC2/MYL12A/PIK3CD/NCK2/GNAI3/ROCK1/NFATC3/EFNA5/SLIT3/PIK3R3/FES/PPP3CB/ABL1/SEMA3B/TRPC1/CXCL12/EPHA5/KRAS/HRAS/SRGAP3/EPHA7/SEMA3G/RGS3/LIMK1/LRRC4/UNC5B/SEMA6A/PLCG1/PTCH1	0.657110458105246
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	27/2056	110/9376	1.11934913335692	IGF1/GNAI2/ANAPC11/CPEB4/PRKACB/PIK3CD/GNAI3/BRAF/CDC27/RPS6KA3/PDE3B/PIK3R3/PRKACA/CDC16/AKT1/KRAS/ANAPC15/ANAPC10/AKT2/ANAPC7/MAD1L1/CDC25B/MAPK13/MAPK10/CCNB2/CDK1/ADCY4	0.667284623334977
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	9/2056	33/9376	1.24372125928546	VAMP5/STX7/VAMP2/VAMP8/BET1/STX2/STX6/BET1L/USE1	0.743273863903352
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	16/2056	63/9376	1.15817429436106	PRDM6/ECHS1/CAMKMT/KMT5A/ALDH9A1/KMT2D/SETD7/DLD/HADH/NSD2/ALDH7A1/SETDB2/SUV39H2/ACAT1/ALDH3A2/TMLHE	0.66757956125241
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	15/2056	59/9376	1.15940117391018	PRKG1/GNAI2/PRKACB/PIK3CD/GNAI3/PDE3B/ADRB1/CGA/ABHD5/PIK3R3/PRKACA/AKT1/AKT2/IRS1/ADCY4	0.650910273732507
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	18/2056	72/9376	1.14007782101167	CXCL8/NFKB1/TANK/MAP3K1/CYLD/PIN1/RIPK1/TNF/MAP3K7/CASP10/TRIM25/RNF125/NFKBIB/MAPK13/MAPK10/ZNFX1/IKBKB/SIKE1	0.632328021068968
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	25/2056	103/9376	1.10687167088512	SAP18/PPP1CB/MAGOH/PPP2R5C/PABPN1/RNMT/PPP1CA/PPP2CB/PNN/UPF3A/MAGOHB/PYM1/PPP1CC/CPSF6/PCF11/PPP2R3C/PABPC4L/CSTF3/CPSF7/WDR82/GLE1/CPSF2/PPP2R5B/CPSF3/CPSF1	0.577979898914267
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	9/2056	34/9376	1.20714122224765	CREB1/RBX1/RORA/BHLHE41/FBXW11/NR1D2/PER3/CLOCK/DBP	0.641250496489196
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	37/2056	156/9376	1.08161229172902	CDK6/CD81/CCND1/EIF3E/NFKB1/RB1/YWHAB/YWHAH/BID/CLDN5/TNFRSF1A/MAP2K2/SOCS3/PIK3CD/STAT3/GRB2/SOS1/BAX/BRAF/CYCS/EIF2S1/PPP2CB/PIK3R3/TP53/RIPK1/TNF/CDK4/AKT1/KRAS/HRAS/APAF1/AKT2/E2F3/IRF9/IKBKB/CLDN11/IFIT1B	0.544746018607792
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	11/2056	43/9376	1.16659125870962	HADHB/ECHS1/ACAA1/ALDH9A1/ACAA2/ACSL5/HADH/ALDH7A1/ACAT1/ALDH3A2/ECI2	0.580253083900557
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	29/2056	122/9376	1.08400841997831	CD36/IGF1/CCND1/CREB1/PIK3CD/EIF4EBP1/RAB10/PPP2R5C/PPP2CB/RAB14/PIK3R3/ACACA/ADIPOR1/SIRT1/STK11/MAP3K7/PPP2R3C/AKT1/RPS6KB2/AKT2/FASN/LEPR/PFKFB2/PPP2R5B/STRADA/PCK2/CREB3L1/IRS1/STRADB	0.494970866122891
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	6/2056	22/9376	1.24372125928546	HNMT/CNDP2/ASPA/ALDH9A1/ALDH7A1/ALDH3A2	0.606523627688766
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	5/2056	18/9376	1.26675313445741	CBR4/ACACA/ACSL5/FASN/ACSF3	0.600338113574006
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/2056	27/9376	1.18230292549359	ELOVL2/HACD4/HACD3/HSD17B4/ACAA1/HSD17B12/FADS2	0.502729757921378
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	27/2056	115/9376	1.0706817797327	GNG2/GNG11/PRKCB/GNAI2/PRKCA/PLCB1/GNGT1/GNG5/ITPR2/GNG10/GNB4/PRKACB/GNAI3/BRAF/GNB1/GNAQ/KCNJ5/GNB2/PRKACA/PLCB2/ITPR1/TRPC1/KRAS/HRAS/ALOX5/GNG7/PLA2G4C	0.404174683780963
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	17/2056	71/9376	1.09190551871541	LDHB/HIF1A/MAP2K2/PIK3CD/GLS/PIK3R3/TP53/PDHB/TIGAR/AKT1/KRAS/HRAS/AKT2/SIRT3/FGFR3/PDGFRB/SCO2	0.411959221735315
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/2056	23/9376	1.18964642192522	IDI1/PMVK/GGPS1/FDPS/ZMPSTE24/ACAT1	0.482586042452097
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	23/2056	98/9376	1.07027713809259	ATP1B3/CALM2/NR4A2/ATP1B1/ATP2B1/PRKCB/PRKCA/PLCB1/ITPR2/CALM3/CREB1/PRKACB/CAMK2D/GNAQ/KCNJ5/CALML4/PRKACA/PLCB2/ITPR1/AGTR1/PRKD2/CREB3L1/ADCY4	0.370630857085349
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	13/2056	54/9376	1.09785271652976	HLA-C/HLA-A/HLA-DRA/CD86/HLA-DPA1/CD28/HLA-DQA2/HLA-DMA/CGA/HLA-DMB/GZMB/PRF1/HLA-F	0.382170244549296
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	10/2056	41/9376	1.11227104488944	GATM/GAMT/GRHPR/SDSL/DLD/ALDH7A1/PHGDH/ALAS2/SDS/SHMT2	0.381807262158102
Genetic Information Processing	Transcription	hsa03040	Spliceosome	55/2056	243/9376	1.032169220669	HSPA1A/LSM3/LSM7/SF3B5/SNRPD2/DDX5/SNRPF/LSM8/SRSF3/SNRPD1/SNRPE/CWC15/SF3B6/LSM6/HNRNPA3/SNU13/LSM5/BCAS2/BUD31/LSM4/SRSF10/SNRPD3/MAGOH/SNRPB2/SNRPC/TXNL4A/SNRPG/U2SURP/SNRPA1/PRPF38B/PUF60/PQBP1/SRSF6/SNRPA/MAGOHB/SRSF1/PRPF8/PRPF31/AQR/THOC1/CDC40/SRSF8/SNRNP40/PPIE/THOC6/RP9/DHX38/PPIH/SNRNP27/U2AF1/HSPA6/RBMX2/U2AF1L4/USP39/THOC5	0.269264190677801
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	19/2056	82/9376	1.05665749264497	LGMN/HLA-C/CD74/HLA-A/HLA-DRA/HSPA1A/CD4/CTSS/HLA-DPA1/CREB1/HLA-DQA2/HLA-DMA/PSME2/HLA-DMB/RFXANK/NFYC/TNF/HLA-F/HSPA6	0.273089244532713
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	38/2056	168/9376	1.03149898091532	FTL/CYBB/PYCARD/HMGB1/SLC25A6/SLC25A5/TLR4/NLRP3/BID/CHMP4A/PPIA/TNFRSF1A/CASP1/CAMK2D/CHMP2A/VDAC3/STAT3/BAX/JAK3/TNFRSF10B/CHMP5/PARP1/GLUD1/PYGL/CYLD/VDAC2/IL1B/IL33/RIPK1/TNF/CAPN1/CHMP6/PLA2G4C/STAT5A/IRF9/BIRC2/MAPK10/TNFRSF10A	0.218328354555312
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	13/2056	56/9376	1.05864369093941	ST6GAL1/MAN1A1/DAD1/MAN1C1/DPM3/KRTCAP2/MGAT4B/B4GALT2/ALG2/TUSC3/MGAT3/ALG8/MAN2A2	0.233264691708602
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/2056	30/9376	1.06407263294423	GPAA1/PIGC/PIGN/PIGX/PIGL/PIGF/PGAP2	0.18627816998096
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	23/2056	103/9376	1.01832193721431	COL3A1/COL14A1/COL1A1/COL15A1/COL1A2/SLC16A10/COL6A1/COL6A2/ATP1B3/ATP1B1/COL5A2/SLC8A1/COL21A1/ELN/KCNQ1/COL16A1/SLC36A1/SLC36A4/COL8A2/SLC7A7/SLC1A1/COL6A6/KCNE3	0.0990881056816609
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	23/2056	104/9376	1.00853038012571	PLD1/SGMS1/LPCAT2/ETNK1/PLPP3/PLD4/PLA2G15/CEPT1/AGPAT3/LCLAT1/CHKB/AGPAT2/GPAT2/PGS1/PTDSS1/MBOAT2/PLB1/PLA2G4C/PNPLA6/GNPAT/GPD1L/AGPAT5/LPCAT4	0.0463596336516762
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	11/2056	49/9376	1.02374334947987	JUN/GNAI2/NFKB1/CREB1/PRKACB/GNAI3/PRKACA/GRIN2C/BDNF/CREB3L1/DLG4	0.0883101636215643
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/2056	17/9376	1.07301441977569	KYAT3/MTR/SEPHS1/INMT	0.159683494544184
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/2056	31/9376	1.02974770930087	PGLS/TKT/GPI/RBKS/PRPS1/PRPS2/RPIA	0.0879197360793646
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	38/2056	174/9376	0.995930050538933	MAN1A1/HSPA1A/DAD1/SEC61B/RBX1/SEC61G/PRKN/MAP3K5/BAX/MAN1C1/BAG1/PLAA/EIF2S1/UBE2D3/NFE2L2/RAD23A/SSR1/UBE2D1/KRTCAP2/UFD1/UBXN1/RNF185/SEC13/SEC23B/UBE2J1/STUB1/TUSC3/NGLY1/CAPN1/EDEM1/UBQLN4/ERO1B/MAPK10/HSPA6/DDIT3/MBTPS2/YOD1/BAG2	-0.0287186604513998
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	13/2056	59/9376	1.00481435072215	HPGDS/LAP3/GPX4/MGST2/GSTO1/RRM1/GCLM/ODC1/GSTA4/GSS/GGCT/RRM2B/LANCL1	0.0196592676799638
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	11/2056	50/9376	1.00326848249027	HLA-DRA/CD86/HLA-DPA1/TNFSF13B/CD28/HLA-DQA2/HLA-DMA/HLA-DMB/ITGA4/CXCL12/MAP3K14	0.0122807562684485
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	37/2056	170/9376	0.992538338292515	RUNX1/MAGI1/JUN/TUBA1B/ARPC3/CCND1/TUBA1A/MSN/ARPC5/MYL6/WAS/CLDN5/MAP3K1/PRKACB/PCNA/RAPGEF6/MYL12A/MAP3K5/ACTR2/YBX3/ROCK1/RAB13/MYH10/ARPC4/PPP2CB/PRKACA/ACTG1/GATA4/SYNPO/STK11/CDK4/NF2/JAM3/NEDD4L/WHAMM/MAPK10/CLDN11	-0.0520314805173793
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	55/2056	254/9376	0.987468978829008	HGF/RYR2/CALM2/PDGFC/ATP2B1/PRKCB/PRKCA/PLCB1/SLC25A6/SLC25A5/ITPR2/FGF7/HRH1/CALM3/SLC8A1/NFATC2/PPP3R1/PRKACB/GNA14/CAMK2D/GNA15/VDAC3/GNAQ/HRH2/NFATC3/PTAFR/ADRB1/CALML4/ITPKB/CD38/VDAC2/PRKACA/PPP3CB/PLCB2/CYSLTR1/ITPR1/VEGFC/KDR/MYLK/RYR1/TPCN1/GRIN2C/MCOLN2/ORAI3/AGTR1/FGFR3/SPHK1/PDE1C/TFEB/PDGFRB/PLCG1/TGFA/PLCE1/FGF2/ADCY4	-0.107300054093922
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	7/2056	32/9376	0.997568093385214	ATG7/GABARAP/GABARAPL2/ATG4C/PPP2CB/ULK2/PIK3R4	-0.00730292971844393
Human Diseases	Immune disease	hsa05310	Asthma	7/2056	32/9376	0.997568093385214	FCER1G/HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DMA/HLA-DMB/TNF	-0.00730292971844393
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	31/2056	144/9376	0.981733679204496	WNT2/IGF1/BMP4/ACVR2A/SMAD5/MAP2K2/PIK3CD/STAT3/GRB2/ID2/JAK3/APC/PIK3R3/WNT2B/TCF7/AKT1/KRAS/BMPR1A/HRAS/SMARCAD1/AKT2/MEIS1/FZD2/FGFR3/TCF3/MAPK13/FZD5/FGF2/SMAD1/FZD7/DVL2	-0.117064733690029
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/2056	18/9376	1.01340250756593	MANBA/MAN2B1/NEU1/MAN2C1	0.0301628549769759
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/2056	18/9376	1.01340250756593	MMADHC/MTR/HCFC1/ABCD4	0.0301628549769759
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	5/2056	23/9376	0.99137201827102	B4GALT2/RXYLT1/B3GALNT2/POMT1/FKTN	-0.0219552972034408
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	5/2056	23/9376	0.99137201827102	ATP6AP2/NLN/AGTR1/THOP1/ENPEP	-0.0219552972034408
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	19/2056	89/9376	0.973549599965024	SPP1/CD36/LAMA2/COL1A1/COL1A2/COL6A1/COL6A2/FREM1/LAMA4/TNXB/ITGB5/CD47/LAMB2/LAMC1/LAMC3/ITGA4/VTN/ITGB4/COL6A6	-0.132871298144863
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	16/2056	75/9376	0.972866407263294	BCAT1/TKT/MAT2A/ACO2/MTR/SDSL/PRPS1/PHGDH/GOT1/ARG2/PRPS2/SDS/RPIA/SHMT2/IDH3B/PYCR2	-0.125030153535021
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	16/2056	75/9376	0.972866407263294	ATP1B3/ATP1B1/PRKCB/PRKCA/PLCB1/ITPR2/CREB1/PRKACB/GNAQ/CGA/PRKACA/PLCB2/ITPR1/TTF1/CREB3L1/ADCY4	-0.125030153535021
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	7/2056	33/9376	0.967338757222026	BCAT1/OGDH/ACO2/PDHB/DLD/GOT1/IDH3B	-0.0996066087572464
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	8/2056	38/9376	0.960065533483514	PTPRC/CD4/JAK3/RFXANK/BTK/BLNK/DCLRE1C/IL2RG	-0.130723721612087
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/2056	14/9376	0.977209560867148	ST3GAL1/B4GALT2/ST3GAL2	-0.0452245282858711
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/2056	24/9376	0.950064850843061	HS2ST1/B3GAT3/GLCE/NDST2/B3GALT6	-0.129807975321816
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	9/2056	44/9376	0.932790944464096	MAN1A1/DAD1/MAN1C1/KRTCAP2/MGAT4B/B4GALT2/ALG2/TUSC3/MAN2A2	-0.236814569818459
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	10/2056	49/9376	0.930675772254427	ST6GAL1/GXYLT2/GALNT11/GALNT10/GALNT1/B4GALT2/B3GLCT/LFNG/RFNG/POMT1	-0.257842049637545
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	11/2056	54/9376	0.928952298602104	RPA3/CENPX/ATR/REV3L/POLK/RPA2/REV1/MLH1/UBE2T/FANCL/MUS81	-0.277481488310461
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	16/2056	78/9376	0.935448468522398	CLTC/ARPC3/WASF2/CLTA/ARPC5/ELMO1/RHOG/PIK3CD/SEPTIN11/ACTR2/ARPC4/PIK3R3/SEPTIN6/ACTG1/SHC1/SEPTIN1	-0.303389630873096
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/2056	15/9376	0.912062256809339	ST3GAL1/ST3GAL2/ST6GALNAC6	-0.180634822039125
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/2056	15/9376	0.912062256809339	AK1/NTPCR/TPK1	-0.180634822039125
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/2056	10/9376	0.912062256809339	SELENBP1/SQOR	-0.14744834148558
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	24/2056	117/9376	0.935448468522398	BAZ2B/EPC1/CDK2AP1/BPTF/EPC2/ARID1A/SMARCA2/HDAC2/MEAF6/ACTG1/BCL7C/MCRS1/INO80D/ACTL6A/BICRAL/POLE3/ING3/TRRAP/TFPT/BCL7B/DMAP1/DPF2/NFRKB/MTA1	-0.372356630758192
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	45/2056	217/9376	0.945686671806918	JUN/PRKCB/GNAI2/PRKCA/CCND1/NFKB1/RB1/FGF7/CREB1/ARRB2/PRKACB/MGST2/GSTO1/MAP2K2/PIK3CD/EIF4EBP1/STAT3/GRB2/SOS1/ARRB1/GNAI3/KPNB1/RPS6KA3/KPNA4/ADRB1/PIK3R3/PRKACA/EPHX1/AIP/AHR/KPNA2/AKT1/KRAS/HRAS/GSTA4/RPS6KB2/AKT2/PAQR8/PAQR7/KPNA5/STAT5A/CREB3L1/DLL4/FGF2/ADCY4	-0.428996655504828
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	10/2056	51/9376	0.89417868314641	ENPP2/PLD1/LPCAT2/PLPP3/PLD4/CEPT1/PLB1/PLA2G4C/TMEM86A/LPCAT4	-0.401583150275789
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	21/2056	105/9376	0.912062256809339	LAMA2/RYR2/IGF1/ITGB5/SLC8A1/DTNA/PRKACB/CACNB4/TPM3/ADRB1/SGCE/PRKACA/EMD/ACTG1/ITGA4/TNF/CACNA2D1/ITGB4/CACNA2D4/TGFB3/ADCY4	-0.480228939204157
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/2056	32/9376	0.855058365758755	AKR1B1/GLA/B4GALT2/GALM/GANC/GALT	-0.435254611219269
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	13/2056	67/9376	0.884836517800105	LDHB/AKR1A1/GPI/ALDH9A1/PDHB/GALM/DLD/ACSS1/ADPGK/ALDH7A1/PCK2/ACSS2/ALDH3A2	-0.501351509874053
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/2056	27/9376	0.844502089638276	HMGCLL1/ECHS1/HADH/ABAT/ACAT1	-0.428810599839658
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/2056	17/9376	0.804760814831769	HSD17B4/AMACR/CH25H	-0.426990660959841
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/2056	17/9376	0.804760814831769	NRP2/CD209/MYH10	-0.426990660959841
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	9/2056	48/9376	0.855058365758755	ATP1B3/ATP1B1/PRKCB/PLCB1/PIK3CD/PIK3R3/PLCB2/AKT1/AKT2	-0.533532840367762
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/2056	38/9376	0.840057341798075	GPI/NAGK/GNPDA1/RENBP/FPGT/AMDHD2/GALT	-0.523565264507897
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/2056	28/9376	0.814341300722624	B3GNT5/A4GALT/B4GALT2/GCNT2/B3GALNT1	-0.521406715151905
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/2056	28/9376	0.814341300722624	AKR1B1/PCBD1/MOCS2/QDPR/PCBD2	-0.521406715151905
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/2056	23/9376	0.793097614616816	GLS/GLUD1/GOT1/ARG2	-0.526496636858979
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/2056	12/9376	0.760051880674449	GGCX/COQ5	-0.44077699898442
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	18/2056	94/9376	0.873251096945111	CCL2/S100A9/JUN/CXCL8/NFKB1/MMP1/TAB2/IL1B/TNF/IL17RA/SRSF1/MAP3K7/IL17RC/CXCL1/TAB3/MAPK13/MAPK10/IKBKB	-0.654529171157549
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	45/2056	226/9376	0.908026583106642	PDE4D/ATP1B3/RYR2/CALM2/JUN/PLD1/ATP1B1/ATP2B1/GNAI2/NFKB1/PDE4B/CALM3/CREB1/PDE3A/PPP1CB/VAV1/PRKACB/CAMK2D/RAC2/MAP2K2/PIK3CD/GNAI3/BRAF/ROCK1/PDE3B/ADRB1/GRIA4/PPP1CA/CALML4/CGA/CREBBP/PIK3R3/PRKACA/PPP1CC/AKT1/GRIN2C/BDNF/AKT2/ABCC4/FXYD1/CREB3L1/MAPK10/PLCE1/ADCY4/PTCH1	-0.741733077199524
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	12/2056	65/9376	0.841903621670159	PLCB1/ITPR2/CREB1/PRKACB/GNAQ/PRKACA/PLCB2/ITPR1/AGTR1/PBX1/CREB3L1/ADCY4	-0.677832033278683
Organismal Systems	Sensory system	hsa04744	Phototransduction	5/2056	29/9376	0.786260566214947	CALM2/GNGT1/CALM3/GNB1/CALML4	-0.610926811147994
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/2056	55/9376	0.829147506190308	SGMS1/ASAH1/ACER3/PLPP3/NEU1/GLA/GALC/SPTLC3/SPHK1/SGPL1	-0.673461953649032
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	16/2056	86/9376	0.848430006334268	LAMA2/RYR2/ITGB5/SLC8A1/DTNA/GJA1/CACNB4/SGCE/LEF1/EMD/ACTG1/ITGA4/TCF7/CACNA2D1/ITGB4/CACNA2D4	-0.748335337818873
Cellular Processes	Cell motility	hsa04814	Motor proteins	38/2056	194/9376	0.893256849452445	TUBA1B/DYNLL1/TNNT3/TUBA1A/MYO5A/KIF1B/MYL6/MYO1F/CAPZB/CAPZA2/TPM3/MYL12A/DCTN4/DYNLRB1/KIF5B/MYH10/MYO1B/DCTN3/CAPZA1/TUBB2A/ACTR1A/DCTN6/ACTG1/DCTN2/DNAH8/TNNT1/KIF20B/MYO7A/KIF13B/KIFC3/DYNC2LI1/TUBG2/STARD9/TUBG1/KIF1C/DYNC2H1/ACTA2/DNALI1	-0.796184815298059
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/2056	19/9376	0.720049150112636	OGDH/PDHB/DLD	-0.647339232920383
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	8/2056	46/9376	0.793097614616816	FTL/BLVRB/BLVRA/UROD/UROS/FECH/ALAS2/HMBS	-0.745495874558412
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/2056	36/9376	0.760051880674449	ENPP1/PYGL/GPI/PGM2L1/GYG1/GANC	-0.764428403320738
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/2056	52/9376	0.789284645315774	IGF1/HSD17B2/PRKACB/CGA/PRKACA/HSD17B1/ALOX5/PLA2G4C/ADCY4	-0.807492273980851
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/2056	31/9376	0.735534078072047	AKR1A1/ALDH9A1/KL/ALDH7A1/ALDH3A2	-0.781632421600091
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	11/2056	63/9376	0.796244827373232	PTGDS/HPGDS/GPX4/LTC4S/TBXAS1/PTGES2/ALOX5/CBR3/PLB1/PLA2G4C/PTGR1	-0.859955084955759
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/2056	20/9376	0.684046692607004	LBR/LIPA/EBP	-0.749608409423116
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/2056	26/9376	0.701586351391799	ACAA1/FADS2/PLB1/PLA2G4C	-0.807497532759336
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/2056	26/9376	0.701586351391799	BTD/SLC46A1/PLB1/ABCD4	-0.807497532759336
NA	NA	hsa04081	Hormone signaling	42/2056	219/9376	0.87458024625553	GNG2/SLC40A1/PRKG1/SLC16A10/GNG11/IGF1/GNAI2/GUCA2A/PLCB1/GNGT1/GNG5/GNG10/RAMP2/GNB4/SMAD5/PRKACB/GNA14/GNA13/GNA15/PIK3CD/STAT3/GNAI3/GNB1/GNAQ/GNB2/ADRB1/CGA/PIK3R3/APPL1/PRKACA/PLCB2/ADIPOR1/STK11/BMPR1A/AGTR1/GNG7/LEPR/THRA/STAT5A/IRS1/ADCY4/SMAD1	-0.99529780635864
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	15/2056	86/9376	0.795403130938377	ATP1B3/RYR2/ATP1B1/PRKCB/PRKCA/PLCB1/CREB1/PRKACB/CAMK2D/VAMP2/GNAQ/PRKACA/PLCB2/CREB3L1/ADCY4	-1.01014101421401
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	18/2056	102/9376	0.804760814831769	ATP1B3/RYR2/ATP1B1/ATP2B1/PRKCB/PRKCA/PLCB1/ITPR2/KCNQ1/RAB11A/GNAQ/CD38/PLCB2/ITPR1/TRPC1/RAB3D/BST1/ADCY4	-1.05069140449302
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	31/2056	168/9376	0.841486010746711	CCND2/IL12RB2/CCND1/PIAS2/IL10RA/SOCS3/PIK3CD/STAT3/GRB2/SOS1/JAK3/IL10RB/CREBBP/PTPN2/PIK3R3/CNTFR/IL2RA/IL6R/AKT1/PTPN6/HRAS/BCL2L1/AKT2/LEPR/IL11RA/IL13RA2/STAT5A/IRF9/PDGFRB/OSMR/IL2RG	-1.09870533718864
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/2056	61/9376	0.747592013778146	FTL/SLC40A1/ATP1B3/ATP1B1/ATP2B1/ATOX1/SLC8A1/SLC46A1/ATP7A/CYBRD1	-1.0481374355733
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/2056	16/9376	0.570038910505837	MIF/GOT1	-0.912205895002404
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	57/2056	298/9376	0.872274306008931	CCL3/CXCL14/CCL2/CCL4/CCL4L2/BMP5/CCL3L1/EDA/CXCL8/IL12RB2/CD4/BMP4/CCL8/TNFRSF1B/TNFSF13B/ACVR2A/CSF1R/TNFRSF1A/IL10RA/TGFBR1/TNFSF12/TNFRSF25/CX3CR1/TNFRSF11A/TNFRSF10B/CCR1/ACVRL1/IL10RB/CCL5/CXCL16/IL1B/IL33/LTB/TNFRSF14/CSF1/TNF/IL17RA/CNTFR/TNFRSF12A/CCL13/CXCL12/IL2RA/IL6R/BMPR1A/IL17RC/LEPR/IL11RA/IL13RA2/CXCL1/GDF6/TGFB3/OSMR/RELT/IL2RG/IL1RN/TNFSF8/TNFRSF10A	-1.18749821844932
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	17/2056	99/9376	0.783083755846402	LAMA2/RYR2/IGF1/ITGB5/SLC8A1/DTNA/CACNB4/TPM3/SGCE/EMD/ACTG1/ITGA4/TNF/CACNA2D1/ITGB4/CACNA2D4/TGFB3	-1.14986683484058
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/2056	17/9376	0.536507209887846	ADO/CSAD	-1.01366481646387
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/2056	47/9376	0.679195297623975	SOCS3/PIK3CD/PIK3R3/TNF/MAPK10/IRS1/IKBKB	-1.16845976081193
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	43/2056	233/9376	0.841602511648102	DCN/COL3A1/LAMA2/COL1A1/COL1A2/COL6A1/COL6A2/VIM/ATP1B3/VCAN/ATP1B1/TNNT3/ANK2/COL5A2/ITGB5/DTNA/CAPZB/CAPZA2/ELN/SYNE1/LBR/TPM3/SPTAN1/FBLN2/MYH10/FMNL1/TLN1/SGCE/CAPZA1/SDC2/EMD/ACTG1/ITGA4/ZYX/TNNT1/FMNL3/ANK3/ITGB4/LMNB2/PDLIM7/COL6A6/AMPD2/MYOM2	-1.29754833378738
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/2056	36/9376	0.633376567228707	GALNT11/GALNT10/ST3GAL1/GALNT1/ST3GAL2	-1.16799150633511
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	12/2056	76/9376	0.720049150112636	CD36/PLTP/SLC27A4/FABP5/DBI/MMP1/ME1/GK/ACAA1/ACSL5/FADS2/PCK2	-1.29863996810993
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/2056	37/9376	0.616258281627932	GLS/GLUD1/ASPA/ABAT/GOT1	-1.23945665346013
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/2056	19/9376	0.480032766741757	ARSB/HYAL2	-1.20233673181043
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/2056	45/9376	0.608041504539559	ABCC5/ABCG2/ABCA2/ABCC4/ABCB7/ABCD4	-1.39676677844211
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/2056	20/9376	0.456031128404669	NPL/CYB5R4	-1.29058196597724
Human Diseases	Substance dependence	hsa05034	Alcoholism	33/2056	191/9376	0.787907185201784	GNG2/HDAC9/CALM2/GNG11/GNAI2/GNGT1/GNG5/GNG10/CALM3/CREB1/PPP1CB/GNB4/PRKACB/GRB2/SOS1/HDAC8/GNAI3/BRAF/GNB1/GNB2/PPP1CA/CALML4/HDAC2/PRKACA/HDAC7/PPP1CC/KRAS/GRIN2C/HRAS/BDNF/SHC1/GNG7/CREB3L1	-1.56943998136587
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/2056	13/9376	0.350793175695899	DCLRE1C	-1.24133469410092
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/2056	35/9376	0.521178432462479	AKR1B1/TIGAR/PFKFB2/FPGT	-1.50401681959566
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/2056	36/9376	0.506701253782966	AKR1B1/AKR1A1/CRYL1/KL	-1.57155460934948
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/2056	43/9376	0.530268753958918	CD36/SLC27A4/PLPP3/AGPAT2/ACAT1	-1.63611828274187
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/2056	37/9376	0.493006625302345	GPI/NAGK/FPGT/GALT	-1.63755015794225
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/2056	17/9376	0.268253604943923	GLUD1	-1.60033897196789
NA	NA	hsa04519	Cadherin signaling	70/2056	404/9376	0.790152945255615	WNT2/CDH11/VIM/PRICKLE1/ARPC3/NFKB1/YWHAB/PCDH10/ARPC5/YWHAH/NCKAP1L/MYO1F/PCDH12/GJA1/PPP1CB/TMC8/ENAH/VAV1/KRT10/MOB1A/LRP6/BRK1/SCN1B/RAC2/MAP2K2/ACTR2/TMC6/ERBIN/ROCK1/CDH5/MYO1B/ARPC4/CYFIP1/PPP1CA/PCDH18/PSENEN/APC/CREBBP/ABI2/LEF1/ACTG1/WNT2B/PPP1CC/KDR/LATS1/ARHGAP35/TCF7/NF2/KRAS/MYO7A/HRAS/KRT1/KRT24/CDH23/MOB1B/APH1B/GABRA3/FZD2/LHFPL2/PKP1/DCHS1/PDGFRB/MAPK13/MAPK10/TEAD2/FZD5/IKBKB/FZD7/DVL2/CDH8	-2.2850230276393
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	8/2056	70/9376	0.521178432462479	HPGDS/SULT1A1/MGST2/GSTO1/EPHX1/GSTA4/NAT1/SULT1A2	-2.13099707116528
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/2056	37/9376	0.369754968976759	MIF/GSTZ1/GOT1	-2.03564366242438
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	20/2056	143/9376	0.637805773992544	C1QA/FCGR3A/C1QC/C1QB/FCGR1A/FCGR2A/HLA-DRA/CD86/C1R/HLA-DPA1/C2/CD28/HLA-DQA2/SNRPD1/HLA-DMA/SNRPD3/HLA-DMB/TNF/C1S/C9	-2.31302206870516
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/2056	30/9376	0.304020752269779	PLB1/PLA2G4C	-2.0234183403195
NA	NA	hsa04082	Neuroactive ligand signaling	30/2056	199/9376	0.687484113172868	GNG2/GNG11/PRKCB/GNAI2/PRKCA/PLCB1/SLC1A6/GNGT1/OGFRL1/GNG5/HRH1/GNG10/GNB4/PRKACB/GNAI3/GNB1/GNAQ/HRH2/GNB2/ADRB1/GRIA4/P2RY13/PRKACA/PLCB2/GRIN2C/GABRA3/GNG7/SLC1A1/ADCY4/P2RY1	-2.36151073912703
NA	NA	hsa03272	Virion - Hepatitis viruses	4/2056	48/9376	0.380025940337224	CD81/CHMP4A/CLDN5/CLDN11	-2.28213599727777
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/2056	41/9376	0.333681313466831	GRIA4/GRIN2C/GABRA3	-2.2659922126898
Organismal Systems	Sensory system	hsa04742	Taste transduction	9/2056	86/9376	0.477241878563026	SCN9A/PLCB1/PRKACB/PRKACA/PLCB2/GABRA3/PDE1C/ADCY4/P2RY1	-2.58097507258485
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/2056	26/9376	0.17539658784795	HHEX	-2.23134975200799
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	50/2056	323/9376	0.705930539326113	ZEB2/MARCKS/CCND2/VIM/CDK6/PRKCB/PRKCA/CCND1/NFKB1/STMN1/TNXB/FSCN1/PLAU/ATM/MAP2K2/PIK3CD/STAT3/GRB2/SOS1/GLS/ROCK1/UBE2I/MDM4/DNMT3A/ZFPM2/EFNA5/APC/CREBBP/PIK3R3/HDAC2/TP53/ABL1/SIRT1/KRAS/HRAS/RASSF1/NOTCH3/BCL2L2/NOTCH1/CDKN2A/SHC1/CDC25B/E2F3/FGFR3/CCNG1/CDKN1B/PDGFRB/IRS1/PLCG1/IKBKB	-2.85033941835669
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/2056	90/9376	0.456031128404669	ATP1B3/ATP1B1/PRKACB/PRKACA/AQP1/EPHX1/ABCG2/ABCC4/ADCY4	-2.74803725392326
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	24/2056	183/9376	0.598073611022517	NOP10/RAN/SNU13/XRN1/XPO1/POP7/CSNK2A1/RPP25/FBL/NHP2/RRP7A/POP5/RPP30/AK6/NMD3/IMP3/NOP56/IMP4/RPP25L/POP4/EMG1/RIOK2/RIOK1/WDR36	-2.90994706585906
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/2056	79/9376	0.404078215042112	HPGDS/MGST2/GSTO1/AKR7A2/EPHX1/GSTA4/CBR3	-2.81885700218996
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/2056	73/9376	0.249880070358723	HPGDS/MGST2/GSTO1/GSTA4	-3.40974794749199
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/2056	66/9376	0.207286876547577	HSD17B2/HSD17B1/HSD17B12	-3.42495467213731
NA	NA	hsa04382	Cornified envelope formation	23/2056	217/9376	0.483350965590202	S100A9/S100A6/SLC27A4/S100A10/S100A4/CLDN5/S100A16/KRT10/PPP2R5C/ABHD5/PPP2CB/PPP2R3C/KRT1/KRT24/S100A2/CAPN1/ITGB4/SPTLC3/PKP1/PPP2R5B/BLMH/CLDN11/S100A12	-4.08077934468822
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/2056	68/9376	0.134126802471962	DHRS4L2/RDH11	-3.79771367538645
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	30/2056	370/9376	0.369754968976759	SPX/LPAR6/C3AR1/OGFRL1/NR3C1/KISS1/HRH1/FPR1/HRH2/TSPO/PTGER4/PTAFR/ADRB1/GRIA4/APLNR/CGA/P2RY13/CYSLTR1/GRIN2C/APLN/AGTR1/LYPD6/GABRA3/LEPR/THRA/S1PR1/GZMA/P2RY1/NPW/CHRNB1	-6.5552004111802
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	15/2056	449/9376	0.152348929311137	PRKG1/CALM2/CALM3/ARRB2/SLC8A1/PRKACB/GRK2/CAMK2D/ARRB1/GNB1/RGS2/CALML4/PRKACA/GNG7/PDE1C	-9.75504261308084