ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0005201 extracellular matrix structural constituent 25/172 168/18639 0.148809523809524 16.1259343853821 3.08661242038258e-23 1.41366848853522e-20 GO:0038024 cargo receptor activity 10/172 65/18639 0.153846153846154 16.6717352415027 3.97860599367627e-10 9.11100772551866e-08 GO:0030020 extracellular matrix structural constituent conferring tensile strength 8/172 44/18639 0.181818181818182 19.7029598308668 5.96474376753795e-09 8.50428384950374e-07 GO:0005539 glycosaminoglycan binding 15/172 242/18639 0.0619834710743802 6.71691812415914 7.42732213930458e-09 8.50428384950374e-07 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 9/172 68/18639 0.132352941176471 14.3425957592339 1.2152324310359e-08 1.11315290682888e-06 GO:0031720 haptoglobin binding 5/172 10/18639 0.5 54.1831395348837 1.5325589088687e-08 1.16985330043644e-06 GO:0005518 collagen binding 9/172 72/18639 0.125 13.5457848837209 2.03366625500706e-08 1.33059877827605e-06 GO:0005344 oxygen carrier activity 5/172 14/18639 0.357142857142857 38.7022425249169 1.18160545330778e-07 6.76469122018702e-06 GO:0005044 scavenger receptor activity 6/172 27/18639 0.222222222222222 24.0813953488372 1.42618533190589e-07 7.2576986890322e-06 GO:1901681 sulfur compound binding 14/172 275/18639 0.0509090909090909 5.51682875264271 2.74998104340415e-07 1.25769872054224e-05 GO:0005178 integrin binding 11/172 161/18639 0.0683229813664596 7.40390726563629 3.02067378296171e-07 1.25769872054224e-05 GO:0008201 heparin binding 11/172 172/18639 0.063953488372093 6.93040156841536 5.85883958067015e-07 2.23612377328911e-05 GO:0015078 proton transmembrane transporter activity 11/172 185/18639 0.0594594594594595 6.44340037712131 1.20568411087165e-06 4.21289315051168e-05 GO:0009055 electron transfer activity 9/172 116/18639 0.0775862068965517 8.40772854851644 1.28778393247082e-06 4.21289315051168e-05 GO:0030021 extracellular matrix structural constituent conferring compression resistance 5/172 22/18639 0.227272727272727 24.6286997885835 1.46398242633086e-06 4.25566418287749e-05 GO:0022853 active monoatomic ion transmembrane transporter activity 9/172 118/18639 0.076271186440678 8.26522467481277 1.4866949110489e-06 4.25566418287749e-05 GO:0048407 platelet-derived growth factor binding 4/172 11/18639 0.363636363636364 39.4059196617336 2.19702789478666e-06 5.91905162242524e-05 GO:0050840 extracellular matrix binding 7/172 67/18639 0.104477611940299 11.3218500520653 2.75200100831241e-06 7.00231367670603e-05 GO:0003954 NADH dehydrogenase activity 6/172 44/18639 0.136363636363636 14.7772198731501 2.98685778113847e-06 7.19989928295484e-05 GO:0019825 oxygen binding 5/172 34/18639 0.147058823529412 15.9362175102599 1.41432215480064e-05 0.000320158703423359 GO:0016209 antioxidant activity 7/172 86/18639 0.0813953488372093 8.8205110870741 1.46797658774902e-05 0.000320158703423359 GO:0015399 primary active transmembrane transporter activity 9/172 166/18639 0.0542168674698795 5.87528019052956 2.41147100663902e-05 0.00050202441865485 GO:0008137 NADH dehydrogenase (ubiquinone) activity 5/172 41/18639 0.121951219512195 13.215399886557 3.61538613623384e-05 0.000719933413215261 GO:0019838 growth factor binding 8/172 136/18639 0.0588235294117647 6.37448700410397 3.85784619289698e-05 0.00073620564847784 GO:0001664 G protein-coupled receptor binding 11/172 297/18639 0.037037037037037 4.01356589147287 0.000101712704620943 0.00186337674865567 GO:0016651 oxidoreductase activity, acting on NAD(P)H 6/172 88/18639 0.0681818181818182 7.38860993657505 0.000164058003814968 0.0028899448364329 GO:0004601 peroxidase activity 5/172 57/18639 0.087719298245614 9.50581395348837 0.000179336387973864 0.00293343091757248 GO:0016504 peptidase activator activity 5/172 57/18639 0.087719298245614 9.50581395348837 0.000179336387973864 0.00293343091757248 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 5/172 58/18639 0.0862068965517241 9.34192060946271 0.000194802823238657 0.00307654113942431 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 5/172 59/18639 0.0847457627118644 9.18358297201419 0.00021126561623511 0.00322532174118935 GO:0004129 cytochrome-c oxidase activity 3/172 15/18639 0.2 21.6732558139535 0.000323818835145835 0.00478416214505782 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/172 16/18639 0.1875 20.3186773255814 0.000395849202707263 0.0056655917137477 GO:0030169 low-density lipoprotein particle binding 3/172 17/18639 0.176470588235294 19.1234610123119 0.000477422581431184 0.00662324589901688 GO:0033218 amide binding 9/172 247/18639 0.0364372469635627 3.94856887298748 0.000491682009970686 0.00662324589901688 GO:0008009 chemokine activity 4/172 45/18639 0.0888888888888889 9.63255813953488 0.000776747978294544 0.0101643021159686 GO:0046332 SMAD binding 5/172 79/18639 0.0632911392405063 6.85862525758022 0.000820065853324855 0.0104330600228551 GO:0005540 hyaluronic acid binding 3/172 24/18639 0.125 13.5457848837209 0.00135520832359038 0.0167752814109296 GO:0030247 polysaccharide binding 3/172 26/18639 0.115384615384615 12.503801431127 0.00171749339905878 0.0207003151781295 GO:0020037 heme binding 6/172 142/18639 0.0422535211267606 4.57885686210285 0.00205930579968017 0.0241836424680389 GO:0070325 lipoprotein particle receptor binding 3/172 31/18639 0.0967741935483871 10.4870592648162 0.00287071012201099 0.0323269126853915 GO:0046906 tetrapyrrole binding 6/172 152/18639 0.0394736842105263 4.27761627906977 0.00289389393035164 0.0323269126853915 GO:0071813 lipoprotein particle binding 3/172 32/18639 0.09375 10.1593386627907 0.0031463916141426 0.0335127292855189 GO:0071814 protein-lipid complex binding 3/172 32/18639 0.09375 10.1593386627907 0.0031463916141426 0.0335127292855189 GO:0030296 protein tyrosine kinase activator activity 3/172 33/18639 0.0909090909090909 9.8514799154334 0.00343778103973785 0.0357841753681804 GO:0022804 active transmembrane transporter activity 11/172 457/18639 0.0240700218818381 2.60837870846267 0.0035202377436834 0.0358281974801555 GO:0019864 IgG binding 2/172 11/18639 0.181818181818182 19.7029598308668 0.00440852651343758 0.0431103045145289 GO:0042379 chemokine receptor binding 4/172 72/18639 0.0555555555555556 6.0203488372093 0.00442398321437305 0.0431103045145289 GO:0030246 carbohydrate binding 8/172 280/18639 0.0285714285714286 3.09617940199336 0.00454924649326346 0.0434073936232222 GO:0042805 actinin binding 3/172 37/18639 0.0810810810810811 8.78645505971087 0.00476572392869144 0.0436540311868136 GO:0043394 proteoglycan binding 3/172 37/18639 0.0810810810810811 8.78645505971087 0.00476572392869144 0.0436540311868136 GO:0061134 peptidase regulator activity 7/172 226/18639 0.0309734513274336 3.35647767030253 0.00507763561382795 0.0455991590418275 GO:0071855 neuropeptide receptor binding 3/172 40/18639 0.075 8.12747093023256 0.00593890720310111 0.0505174638980549 GO:0005125 cytokine activity 7/172 234/18639 0.0299145299145299 3.24172629695886 0.00611503981292077 0.0505174638980549 GO:0008035 high-density lipoprotein particle binding 2/172 13/18639 0.153846153846154 16.6717352415027 0.00617680781286261 0.0505174638980549 GO:0035325 Toll-like receptor binding 2/172 13/18639 0.153846153846154 16.6717352415027 0.00617680781286261 0.0505174638980549 GO:0070700 BMP receptor binding 2/172 13/18639 0.153846153846154 16.6717352415027 0.00617680781286261 0.0505174638980549 GO:0001540 amyloid-beta binding 4/172 83/18639 0.0481927710843374 5.22247128047072 0.00730915261159493 0.0587296823879031 GO:0005041 low-density lipoprotein particle receptor activity 2/172 15/18639 0.133333333333333 14.4488372093023 0.00821495745552261 0.0648698364591268 GO:0038187 pattern recognition receptor activity 3/172 48/18639 0.0625 6.77289244186047 0.00985366793696501 0.0764911850022029 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/172 17/18639 0.117647058823529 12.7489740082079 0.0105125796320478 0.0776574430883528 GO:0019198 transmembrane receptor protein phosphatase activity 2/172 17/18639 0.117647058823529 12.7489740082079 0.0105125796320478 0.0776574430883528 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/172 17/18639 0.117647058823529 12.7489740082079 0.0105125796320478 0.0776574430883528 GO:0019955 cytokine binding 5/172 144/18639 0.0347222222222222 3.76271802325581 0.0108582548590625 0.0788465645605347 GO:0048020 CCR chemokine receptor binding 3/172 50/18639 0.06 6.50197674418605 0.0110178605499437 0.0788465645605347 GO:0030228 lipoprotein particle receptor activity 2/172 18/18639 0.111111111111111 12.0406976744186 0.0117555229108173 0.0828312229716053 GO:0005126 cytokine receptor binding 7/172 275/18639 0.0254545454545455 2.75841437632135 0.0140661083989997 0.0976102673748769 GO:0072542 protein phosphatase activator activity 2/172 21/18639 0.0952380952380952 10.3205980066445 0.0158460866553698 0.108321010271036 GO:0008083 growth factor activity 5/172 162/18639 0.0308641975308642 3.34463824289406 0.0173004967355379 0.11652393389524 GO:0005158 insulin receptor binding 2/172 23/18639 0.0869565217391304 9.42315470171891 0.0188625875299558 0.123415215553139 GO:0031681 G-protein beta-subunit binding 2/172 23/18639 0.0869565217391304 9.42315470171891 0.0188625875299558 0.123415215553139 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/172 24/18639 0.0833333333333333 9.03052325581395 0.0204541674578072 0.128328886242133 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/172 24/18639 0.0833333333333333 9.03052325581395 0.0204541674578072 0.128328886242133 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/172 24/18639 0.0833333333333333 9.03052325581395 0.0204541674578072 0.128328886242133 GO:0019211 phosphatase activator activity 2/172 25/18639 0.08 8.6693023255814 0.022099779580946 0.136779716865855 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/172 26/18639 0.0769230769230769 8.33586762075134 0.0237983034294365 0.141553545073791 GO:0019865 immunoglobulin binding 2/172 26/18639 0.0769230769230769 8.33586762075134 0.0237983034294365 0.141553545073791 GO:0050750 low-density lipoprotein particle receptor binding 2/172 26/18639 0.0769230769230769 8.33586762075134 0.0237983034294365 0.141553545073791 GO:0051393 alpha-actinin binding 2/172 28/18639 0.0714285714285714 7.74044850498339 0.0273496835603681 0.160591731674982 GO:0003785 actin monomer binding 2/172 29/18639 0.0689655172413793 7.47353648757017 0.029200377458969 0.169288264255795 GO:0001968 fibronectin binding 2/172 30/18639 0.0666666666666667 7.22441860465116 0.0310996579326311 0.175847448557346 GO:0033612 receptor serine/threonine kinase binding 2/172 30/18639 0.0666666666666667 7.22441860465116 0.0310996579326311 0.175847448557346 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 9/172 484/18639 0.0185950413223141 2.01507543724774 0.0359207071297975 0.20063029104204 GO:0002020 protease binding 4/172 136/18639 0.0294117647058824 3.18724350205198 0.0373825548317343 0.204676599949598 GO:0140297 DNA-binding transcription factor binding 9/172 488/18639 0.0184426229508197 1.99855842546702 0.0375389397287473 0.204676599949598 GO:0001216 DNA-binding transcription activator activity 9/172 491/18639 0.0183299389002037 1.98634727419126 0.038784961459823 0.208982498218811 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 7/172 349/18639 0.0200573065902579 2.17353568334777 0.0434759076559674 0.231534484958524 GO:0008081 phosphoric diester hydrolase activity 3/172 87/18639 0.0344827586206897 3.73676824378508 0.0466238222240621 0.245444949179545 GO:0005109 frizzled binding 2/172 38/18639 0.0526315789473684 5.70348837209302 0.0479209373331071 0.24940669657458 GO:0042562 hormone binding 3/172 94/18639 0.0319148936170213 3.45849826818407 0.0563162382112719 0.285332359101562 GO:0008307 structural constituent of muscle 2/172 42/18639 0.0476190476190476 5.16029900332226 0.0573156703872133 0.285332359101562 GO:0042056 chemoattractant activity 2/172 42/18639 0.0476190476190476 5.16029900332226 0.0573156703872133 0.285332359101562 GO:0048487 beta-tubulin binding 2/172 42/18639 0.0476190476190476 5.16029900332226 0.0573156703872133 0.285332359101562 GO:0048156 tau protein binding 2/172 43/18639 0.0465116279069767 5.04029204975663 0.0597569070014066 0.29428670329725 GO:0030276 clathrin binding 2/172 46/18639 0.0434782608695652 4.71157735085945 0.0672888852842673 0.327854355959515 GO:0005504 fatty acid binding 2/172 47/18639 0.0425531914893617 4.61133102424542 0.0698661749986727 0.336828506835706 GO:0008013 beta-catenin binding 3/172 106/18639 0.0283018867924528 3.06697016235191 0.0749466052813385 0.352500697599586 GO:0019888 protein phosphatase regulator activity 3/172 107/18639 0.0280373831775701 3.03830688980656 0.0766086149168758 0.352500697599586 GO:0005021 vascular endothelial growth factor receptor activity 2/172 51/18639 0.0392156862745098 4.24965800273598 0.0804868797816315 0.352500697599586 GO:0140104 molecular carrier activity 5/172 249/18639 0.0200803212851406 2.17602970019613 0.0812274788118905 0.352500697599586 GO:0016860 intramolecular oxidoreductase activity 2/172 53/18639 0.0377358490566038 4.08929354980255 0.0859732337044668 0.352500697599586 GO:0017046 peptide hormone binding 2/172 53/18639 0.0377358490566038 4.08929354980255 0.0859732337044668 0.352500697599586 GO:0005131 growth hormone receptor binding 1/172 10/18639 0.1 10.8366279069767 0.0885609337273985 0.352500697599586 GO:0005381 iron ion transmembrane transporter activity 1/172 10/18639 0.1 10.8366279069767 0.0885609337273985 0.352500697599586 GO:0008239 dipeptidyl-peptidase activity 1/172 10/18639 0.1 10.8366279069767 0.0885609337273985 0.352500697599586 GO:0030957 Tat protein binding 1/172 10/18639 0.1 10.8366279069767 0.0885609337273985 0.352500697599586 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/172 10/18639 0.1 10.8366279069767 0.0885609337273985 0.352500697599586 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/172 10/18639 0.1 10.8366279069767 0.0885609337273985 0.352500697599586 GO:0047429 nucleoside triphosphate diphosphatase activity 1/172 10/18639 0.1 10.8366279069767 0.0885609337273985 0.352500697599586 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/172 10/18639 0.1 10.8366279069767 0.0885609337273985 0.352500697599586 GO:0070097 delta-catenin binding 1/172 10/18639 0.1 10.8366279069767 0.0885609337273985 0.352500697599586 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/172 10/18639 0.1 10.8366279069767 0.0885609337273985 0.352500697599586 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/172 10/18639 0.1 10.8366279069767 0.0885609337273985 0.352500697599586 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/172 10/18639 0.1 10.8366279069767 0.0885609337273985 0.352500697599586 GO:0019208 phosphatase regulator activity 3/172 117/18639 0.0256410256410256 2.77862254025045 0.0940965702598787 0.352500697599586 GO:0008046 axon guidance receptor activity 1/172 11/18639 0.0909090909090909 9.8514799154334 0.0969761744487944 0.352500697599586 GO:0008199 ferric iron binding 1/172 11/18639 0.0909090909090909 9.8514799154334 0.0969761744487944 0.352500697599586 GO:0008526 phosphatidylinositol transfer activity 1/172 11/18639 0.0909090909090909 9.8514799154334 0.0969761744487944 0.352500697599586 GO:0015173 aromatic amino acid transmembrane transporter activity 1/172 11/18639 0.0909090909090909 9.8514799154334 0.0969761744487944 0.352500697599586 GO:0032050 clathrin heavy chain binding 1/172 11/18639 0.0909090909090909 9.8514799154334 0.0969761744487944 0.352500697599586 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/172 11/18639 0.0909090909090909 9.8514799154334 0.0969761744487944 0.352500697599586 GO:0045294 alpha-catenin binding 1/172 11/18639 0.0909090909090909 9.8514799154334 0.0969761744487944 0.352500697599586 GO:0050786 RAGE receptor binding 1/172 11/18639 0.0909090909090909 9.8514799154334 0.0969761744487944 0.352500697599586 GO:0050998 nitric-oxide synthase binding 1/172 11/18639 0.0909090909090909 9.8514799154334 0.0969761744487944 0.352500697599586 GO:0097493 structural molecule activity conferring elasticity 1/172 11/18639 0.0909090909090909 9.8514799154334 0.0969761744487944 0.352500697599586 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/172 11/18639 0.0909090909090909 9.8514799154334 0.0969761744487944 0.352500697599586 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/172 11/18639 0.0909090909090909 9.8514799154334 0.0969761744487944 0.352500697599586 GO:0043177 organic acid binding 4/172 189/18639 0.0211640211640212 2.29346622369878 0.097995205369582 0.353400031962745 GO:0005095 GTPase inhibitor activity 1/172 12/18639 0.0833333333333333 9.03052325581395 0.105314165537199 0.365017058197798 GO:0005165 neurotrophin receptor binding 1/172 12/18639 0.0833333333333333 9.03052325581395 0.105314165537199 0.365017058197798 GO:0045295 gamma-catenin binding 1/172 12/18639 0.0833333333333333 9.03052325581395 0.105314165537199 0.365017058197798 GO:0097677 STAT family protein binding 1/172 12/18639 0.0833333333333333 9.03052325581395 0.105314165537199 0.365017058197798 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/172 12/18639 0.0833333333333333 9.03052325581395 0.105314165537199 0.365017058197798 GO:0004714 transmembrane receptor protein tyrosine kinase activity 2/172 60/18639 0.0333333333333333 3.61220930232558 0.105998403363116 0.365017058197798 GO:0015026 coreceptor activity 2/172 61/18639 0.0327868852459016 3.55299275638582 0.108954280479014 0.372395973577525 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/172 13/18639 0.0769230769230769 8.33586762075134 0.113575612014227 0.37422755613321 GO:0005542 folic acid binding 1/172 13/18639 0.0769230769230769 8.33586762075134 0.113575612014227 0.37422755613321 GO:0017154 semaphorin receptor activity 1/172 13/18639 0.0769230769230769 8.33586762075134 0.113575612014227 0.37422755613321 GO:0031994 insulin-like growth factor I binding 1/172 13/18639 0.0769230769230769 8.33586762075134 0.113575612014227 0.37422755613321 GO:0035673 oligopeptide transmembrane transporter activity 1/172 13/18639 0.0769230769230769 8.33586762075134 0.113575612014227 0.37422755613321 GO:0005507 copper ion binding 2/172 63/18639 0.0317460317460317 3.44019933554817 0.114930684605714 0.374272720316131 GO:0042578 phosphoric ester hydrolase activity 6/172 363/18639 0.0165289256198347 1.79117816644244 0.12021928653961 0.374272720316131 GO:0008195 phosphatidate phosphatase activity 1/172 14/18639 0.0714285714285714 7.74044850498339 0.121761212504593 0.374272720316131 GO:0015386 potassium:proton antiporter activity 1/172 14/18639 0.0714285714285714 7.74044850498339 0.121761212504593 0.374272720316131 GO:0019763 immunoglobulin receptor activity 1/172 14/18639 0.0714285714285714 7.74044850498339 0.121761212504593 0.374272720316131 GO:0019992 diacylglycerol binding 1/172 14/18639 0.0714285714285714 7.74044850498339 0.121761212504593 0.374272720316131 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/172 14/18639 0.0714285714285714 7.74044850498339 0.121761212504593 0.374272720316131 GO:0031404 chloride ion binding 1/172 14/18639 0.0714285714285714 7.74044850498339 0.121761212504593 0.374272720316131 GO:0034236 protein kinase A catalytic subunit binding 1/172 14/18639 0.0714285714285714 7.74044850498339 0.121761212504593 0.374272720316131 GO:0042043 neurexin family protein binding 1/172 14/18639 0.0714285714285714 7.74044850498339 0.121761212504593 0.374272720316131 GO:0005179 hormone activity 3/172 132/18639 0.0227272727272727 2.46286997885835 0.123041611761728 0.375687054579144 GO:0005523 tropomyosin binding 1/172 15/18639 0.0666666666666667 7.22441860465116 0.129871659293813 0.382310511469162 GO:0030553 cGMP binding 1/172 15/18639 0.0666666666666667 7.22441860465116 0.129871659293813 0.382310511469162 GO:0031005 filamin binding 1/172 15/18639 0.0666666666666667 7.22441860465116 0.129871659293813 0.382310511469162 GO:0141050 histone H3K deacetylase activity 1/172 15/18639 0.0666666666666667 7.22441860465116 0.129871659293813 0.382310511469162 GO:0141051 histone H4K deacetylase activity 1/172 15/18639 0.0666666666666667 7.22441860465116 0.129871659293813 0.382310511469162 GO:1990841 promoter-specific chromatin binding 2/172 68/18639 0.0294117647058824 3.18724350205198 0.130219300849758 0.382310511469162 GO:0097110 scaffold protein binding 2/172 70/18639 0.0285714285714286 3.09617940199336 0.13646101386513 0.387495082088999 GO:0030295 protein kinase activator activity 3/172 139/18639 0.0215827338129496 2.33884055546261 0.137533933559409 0.387495082088999 GO:0005159 insulin-like growth factor receptor binding 1/172 16/18639 0.0625 6.77289244186047 0.137907638385386 0.387495082088999 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/172 16/18639 0.0625 6.77289244186047 0.137907638385386 0.387495082088999 GO:0015385 sodium:proton antiporter activity 1/172 16/18639 0.0625 6.77289244186047 0.137907638385386 0.387495082088999 GO:0015562 efflux transmembrane transporter activity 1/172 16/18639 0.0625 6.77289244186047 0.137907638385386 0.387495082088999 GO:0030275 LRR domain binding 1/172 16/18639 0.0625 6.77289244186047 0.137907638385386 0.387495082088999 GO:0008429 phosphatidylethanolamine binding 1/172 17/18639 0.0588235294117647 6.37448700410397 0.14586982955747 0.394746203901769 GO:0015278 intracellularly gated calcium channel activity 1/172 17/18639 0.0588235294117647 6.37448700410397 0.14586982955747 0.394746203901769 GO:0036041 long-chain fatty acid binding 1/172 17/18639 0.0588235294117647 6.37448700410397 0.14586982955747 0.394746203901769 GO:0048038 quinone binding 1/172 17/18639 0.0588235294117647 6.37448700410397 0.14586982955747 0.394746203901769 GO:0048029 monosaccharide binding 2/172 74/18639 0.027027027027027 2.92881835323696 0.149135461705316 0.394746203901769 GO:0008525 phosphatidylcholine transporter activity 1/172 18/18639 0.0555555555555556 6.0203488372093 0.153758906419037 0.394746203901769 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/172 18/18639 0.0555555555555556 6.0203488372093 0.153758906419037 0.394746203901769 GO:0017075 syntaxin-1 binding 1/172 18/18639 0.0555555555555556 6.0203488372093 0.153758906419037 0.394746203901769 GO:0034185 apolipoprotein binding 1/172 18/18639 0.0555555555555556 6.0203488372093 0.153758906419037 0.394746203901769 GO:0035615 clathrin adaptor activity 1/172 18/18639 0.0555555555555556 6.0203488372093 0.153758906419037 0.394746203901769 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/172 18/18639 0.0555555555555556 6.0203488372093 0.153758906419037 0.394746203901769 GO:1901611 phosphatidylglycerol binding 1/172 18/18639 0.0555555555555556 6.0203488372093 0.153758906419037 0.394746203901769 GO:0098631 cell adhesion mediator activity 2/172 76/18639 0.0263157894736842 2.85174418604651 0.15555941383371 0.394746203901769 GO:0019209 kinase activator activity 3/172 148/18639 0.0202702702702703 2.19661376492772 0.156967027274579 0.394746203901769 GO:0003756 protein disulfide isomerase activity 1/172 19/18639 0.0526315789473684 5.70348837209302 0.16157553646554 0.394746203901769 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/172 19/18639 0.0526315789473684 5.70348837209302 0.16157553646554 0.394746203901769 GO:0005520 insulin-like growth factor binding 1/172 19/18639 0.0526315789473684 5.70348837209302 0.16157553646554 0.394746203901769 GO:0015245 fatty acid transmembrane transporter activity 1/172 19/18639 0.0526315789473684 5.70348837209302 0.16157553646554 0.394746203901769 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/172 19/18639 0.0526315789473684 5.70348837209302 0.16157553646554 0.394746203901769 GO:0022821 solute:potassium antiporter activity 1/172 19/18639 0.0526315789473684 5.70348837209302 0.16157553646554 0.394746203901769 GO:0042577 lipid phosphatase activity 1/172 19/18639 0.0526315789473684 5.70348837209302 0.16157553646554 0.394746203901769 GO:0043395 heparan sulfate proteoglycan binding 1/172 19/18639 0.0526315789473684 5.70348837209302 0.16157553646554 0.394746203901769 GO:0046624 sphingolipid transporter activity 1/172 19/18639 0.0526315789473684 5.70348837209302 0.16157553646554 0.394746203901769 GO:0097001 ceramide binding 1/172 19/18639 0.0526315789473684 5.70348837209302 0.16157553646554 0.394746203901769 GO:0019199 transmembrane receptor protein kinase activity 2/172 78/18639 0.0256410256410256 2.77862254025045 0.162035559680202 0.394746203901769 GO:0033293 monocarboxylic acid binding 2/172 79/18639 0.0253164556962025 2.74345010303209 0.165291934021398 0.400548707840214 GO:0048306 calcium-dependent protein binding 2/172 80/18639 0.025 2.70915697674419 0.168559847653301 0.401806914815553 GO:0016004 phospholipase activator activity 1/172 20/18639 0.05 5.41831395348837 0.169320381134065 0.401806914815553 GO:0016505 peptidase activator activity involved in apoptotic process 1/172 20/18639 0.05 5.41831395348837 0.169320381134065 0.401806914815553 GO:0140939 histone H4 methyltransferase activity 1/172 20/18639 0.05 5.41831395348837 0.169320381134065 0.401806914815553 GO:0005506 iron ion binding 3/172 154/18639 0.0194805194805195 2.11103141045001 0.170368800936467 0.40221088056135 GO:0140375 immune receptor activity 3/172 156/18639 0.0192307692307692 2.08396690518784 0.174908088190305 0.407353245743536 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/172 21/18639 0.0476190476190476 5.16029900332226 0.176994095857999 0.407353245743536 GO:0005248 voltage-gated sodium channel activity 1/172 21/18639 0.0476190476190476 5.16029900332226 0.176994095857999 0.407353245743536 GO:0061891 calcium ion sensor activity 1/172 21/18639 0.0476190476190476 5.16029900332226 0.176994095857999 0.407353245743536 GO:0140312 cargo adaptor activity 1/172 21/18639 0.0476190476190476 5.16029900332226 0.176994095857999 0.407353245743536 GO:0004527 exonuclease activity 2/172 84/18639 0.0238095238095238 2.58014950166113 0.181737288501526 0.408432740074944 GO:0099106 ion channel regulator activity 3/172 160/18639 0.01875 2.03186773255814 0.184087031722263 0.408432740074944 GO:0004407 histone deacetylase activity 1/172 22/18639 0.0454545454545455 4.9257399577167 0.184597330121208 0.408432740074944 GO:0005243 gap junction channel activity 1/172 22/18639 0.0454545454545455 4.9257399577167 0.184597330121208 0.408432740074944 GO:0008093 cytoskeletal anchor activity 1/172 22/18639 0.0454545454545455 4.9257399577167 0.184597330121208 0.408432740074944 GO:0033558 protein lysine deacetylase activity 1/172 22/18639 0.0454545454545455 4.9257399577167 0.184597330121208 0.408432740074944 GO:0061133 endopeptidase activator activity 1/172 22/18639 0.0454545454545455 4.9257399577167 0.184597330121208 0.408432740074944 GO:0140784 metal ion sensor activity 1/172 22/18639 0.0454545454545455 4.9257399577167 0.184597330121208 0.408432740074944 GO:0004857 enzyme inhibitor activity 6/172 416/18639 0.0144230769230769 1.56297517889088 0.187413003911908 0.412669018229105 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/172 23/18639 0.0434782608695652 4.71157735085945 0.19213072751172 0.4174176986526 GO:0099186 structural constituent of postsynapse 1/172 23/18639 0.0434782608695652 4.71157735085945 0.19213072751172 0.4174176986526 GO:0004197 cysteine-type endopeptidase activity 2/172 88/18639 0.0227272727272727 2.46286997885835 0.195061856850761 0.4174176986526 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 2/172 89/18639 0.0224719101123595 2.43519728246668 0.19841267014503 0.4174176986526 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 2/172 89/18639 0.0224719101123595 2.43519728246668 0.19841267014503 0.4174176986526 GO:0042277 peptide binding 4/172 249/18639 0.0160642570281124 1.74082376015691 0.198552673967286 0.4174176986526 GO:0004622 lysophospholipase activity 1/172 24/18639 0.0416666666666667 4.51526162790698 0.199594925774933 0.4174176986526 GO:0035035 histone acetyltransferase binding 1/172 24/18639 0.0416666666666667 4.51526162790698 0.199594925774933 0.4174176986526 GO:0050431 transforming growth factor beta binding 1/172 24/18639 0.0416666666666667 4.51526162790698 0.199594925774933 0.4174176986526 GO:0060229 lipase activator activity 1/172 24/18639 0.0416666666666667 4.51526162790698 0.199594925774933 0.4174176986526 GO:0070300 phosphatidic acid binding 1/172 24/18639 0.0416666666666667 4.51526162790698 0.199594925774933 0.4174176986526 GO:0140793 histone H2AXY142 phosphatase activity 2/172 90/18639 0.0222222222222222 2.40813953488372 0.201770503643578 0.41769258352235 GO:0016247 channel regulator activity 3/172 168/18639 0.0178571428571429 1.93511212624585 0.202811092917853 0.41769258352235 GO:0072341 modified amino acid binding 2/172 91/18639 0.021978021978022 2.38167646307181 0.205134945573143 0.41769258352235 GO:0003707 nuclear steroid receptor activity 1/172 25/18639 0.04 4.3346511627907 0.206990556866349 0.41769258352235 GO:0005537 D-mannose binding 1/172 25/18639 0.04 4.3346511627907 0.206990556866349 0.41769258352235 GO:0120020 cholesterol transfer activity 1/172 25/18639 0.04 4.3346511627907 0.206990556866349 0.41769258352235 GO:0141108 transporter regulator activity 3/172 170/18639 0.0176470588235294 1.91234610123119 0.207561141943551 0.41769258352235 GO:0019887 protein kinase regulator activity 4/172 255/18639 0.0156862745098039 1.69986320109439 0.209975122492669 0.41769258352235 GO:0005112 Notch binding 1/172 26/18639 0.0384615384615385 4.16793381037567 0.214318247003826 0.41769258352235 GO:0008143 poly(A) binding 1/172 26/18639 0.0384615384615385 4.16793381037567 0.214318247003826 0.41769258352235 GO:0008198 ferrous iron binding 1/172 26/18639 0.0384615384615385 4.16793381037567 0.214318247003826 0.41769258352235 GO:0034237 protein kinase A regulatory subunit binding 1/172 26/18639 0.0384615384615385 4.16793381037567 0.214318247003826 0.41769258352235 GO:0050681 nuclear androgen receptor binding 1/172 26/18639 0.0384615384615385 4.16793381037567 0.214318247003826 0.41769258352235 GO:0051139 metal cation:proton antiporter activity 1/172 26/18639 0.0384615384615385 4.16793381037567 0.214318247003826 0.41769258352235 GO:0070412 R-SMAD binding 1/172 26/18639 0.0384615384615385 4.16793381037567 0.214318247003826 0.41769258352235 GO:0120014 phospholipid transfer activity 1/172 26/18639 0.0384615384615385 4.16793381037567 0.214318247003826 0.41769258352235 GO:0008266 poly(U) RNA binding 1/172 27/18639 0.037037037037037 4.01356589147287 0.221578616719366 0.425503747839059 GO:0015252 proton channel activity 1/172 27/18639 0.037037037037037 4.01356589147287 0.221578616719366 0.425503747839059 GO:0035255 ionotropic glutamate receptor binding 1/172 27/18639 0.037037037037037 4.01356589147287 0.221578616719366 0.425503747839059 GO:0004896 cytokine receptor activity 2/172 96/18639 0.0208333333333333 2.25763081395349 0.222042348763177 0.425503747839059 GO:0045499 chemorepellent activity 1/172 28/18639 0.0357142857142857 3.87022425249169 0.228772280910439 0.429540022807655 GO:0046625 sphingolipid binding 1/172 28/18639 0.0357142857142857 3.87022425249169 0.228772280910439 0.429540022807655 GO:0046875 ephrin receptor binding 1/172 28/18639 0.0357142857142857 3.87022425249169 0.228772280910439 0.429540022807655 GO:0051019 mitogen-activated protein kinase binding 1/172 28/18639 0.0357142857142857 3.87022425249169 0.228772280910439 0.429540022807655 GO:0004725 protein tyrosine phosphatase activity 2/172 98/18639 0.0204081632653061 2.21155671570954 0.228837916080934 0.429540022807655 GO:0043236 laminin binding 1/172 29/18639 0.0344827586206897 3.73676824378508 0.235899848890849 0.439195653626053 GO:0099604 ligand-gated calcium channel activity 1/172 29/18639 0.0344827586206897 3.73676824378508 0.235899848890849 0.439195653626053 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/172 30/18639 0.0333333333333333 3.61220930232558 0.242961924441133 0.443332913920473 GO:0008187 poly-pyrimidine tract binding 1/172 30/18639 0.0333333333333333 3.61220930232558 0.242961924441133 0.443332913920473 GO:0031210 phosphatidylcholine binding 1/172 30/18639 0.0333333333333333 3.61220930232558 0.242961924441133 0.443332913920473 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/172 30/18639 0.0333333333333333 3.61220930232558 0.242961924441133 0.443332913920473 GO:0098918 structural constituent of synapse 1/172 30/18639 0.0333333333333333 3.61220930232558 0.242961924441133 0.443332913920473 GO:0016791 phosphatase activity 4/172 273/18639 0.0146520146520147 1.58778430871454 0.245276505944343 0.445780316359163 GO:0031406 carboxylic acid binding 3/172 187/18639 0.0160427807486631 1.73849645566472 0.248832942491715 0.447192462825005 GO:0005184 neuropeptide hormone activity 1/172 31/18639 0.032258064516129 3.4956864216054 0.249959105858518 0.447192462825005 GO:0017147 Wnt-protein binding 1/172 31/18639 0.032258064516129 3.4956864216054 0.249959105858518 0.447192462825005 GO:0072349 modified amino acid transmembrane transporter activity 1/172 31/18639 0.032258064516129 3.4956864216054 0.249959105858518 0.447192462825005 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/172 32/18639 0.03125 3.38644622093023 0.256891986006429 0.450791301114731 GO:0043425 bHLH transcription factor binding 1/172 32/18639 0.03125 3.38644622093023 0.256891986006429 0.450791301114731 GO:0070717 poly-purine tract binding 1/172 32/18639 0.03125 3.38644622093023 0.256891986006429 0.450791301114731 GO:0120015 sterol transfer activity 1/172 32/18639 0.03125 3.38644622093023 0.256891986006429 0.450791301114731 GO:0160041 neuropeptide activity 1/172 32/18639 0.03125 3.38644622093023 0.256891986006429 0.450791301114731 GO:0019956 chemokine binding 1/172 33/18639 0.0303030303030303 3.2838266384778 0.263761152363547 0.457585635539791 GO:0140311 protein sequestering activity 1/172 33/18639 0.0303030303030303 3.2838266384778 0.263761152363547 0.457585635539791 GO:0140416 transcription regulator inhibitor activity 1/172 33/18639 0.0303030303030303 3.2838266384778 0.263761152363547 0.457585635539791 GO:0004222 metalloendopeptidase activity 2/172 110/18639 0.0181818181818182 1.97029598308668 0.269815560713127 0.465863803305162 GO:0051427 hormone receptor binding 1/172 34/18639 0.0294117647058824 3.18724350205198 0.27056718707243 0.465863803305162 GO:0019207 kinase regulator activity 4/172 287/18639 0.0139372822299652 1.51033141560652 0.273589312208895 0.469303014950089 GO:0005200 structural constituent of cytoskeleton 2/172 112/18639 0.0178571428571429 1.93511212624585 0.276655288009343 0.472149760150057 GO:0016229 steroid dehydrogenase activity 1/172 35/18639 0.0285714285714286 3.09617940199336 0.277310666987697 0.472149760150057 GO:0019213 deacetylase activity 1/172 37/18639 0.027027027027027 2.92881835323696 0.290612243702254 0.489339733881 GO:0022829 wide pore channel activity 1/172 37/18639 0.027027027027027 2.92881835323696 0.290612243702254 0.489339733881 GO:0030551 cyclic nucleotide binding 1/172 37/18639 0.027027027027027 2.92881835323696 0.290612243702254 0.489339733881 GO:0005501 retinoid binding 1/172 38/18639 0.0263157894736842 2.85174418604651 0.297171468198717 0.494925572490954 GO:0019840 isoprenoid binding 1/172 38/18639 0.0263157894736842 2.85174418604651 0.297171468198717 0.494925572490954 GO:0042887 amide transmembrane transporter activity 1/172 38/18639 0.0263157894736842 2.85174418604651 0.297171468198717 0.494925572490954 GO:0004518 nuclease activity 3/172 209/18639 0.0143540669856459 1.55549682875264 0.303799748683371 0.504131467018057 GO:0050997 quaternary ammonium group binding 1/172 40/18639 0.025 2.70915697674419 0.310109570396656 0.512744343832738 GO:0001530 lipopolysaccharide binding 1/172 41/18639 0.024390243902439 2.6430799773114 0.316489545335727 0.517686470584868 GO:0017080 sodium channel regulator activity 1/172 41/18639 0.024390243902439 2.6430799773114 0.316489545335727 0.517686470584868 GO:0140828 metal cation:monoatomic cation antiporter activity 1/172 41/18639 0.024390243902439 2.6430799773114 0.316489545335727 0.517686470584868 GO:0004175 endopeptidase activity 5/172 405/18639 0.0123456790123457 1.33785529715762 0.319167361826591 0.520208724970031 GO:0019894 kinesin binding 1/172 42/18639 0.0238095238095238 2.58014950166113 0.322810859358861 0.522428881930595 GO:0031492 nucleosomal DNA binding 1/172 42/18639 0.0238095238095238 2.58014950166113 0.322810859358861 0.522428881930595 GO:0042826 histone deacetylase binding 2/172 127/18639 0.015748031496063 1.70655557590185 0.327702085773483 0.528477307338928 GO:0001046 core promoter sequence-specific DNA binding 1/172 44/18639 0.0227272727272727 2.46286997885835 0.335279644722618 0.53504556544585 GO:0016790 thiolester hydrolase activity 1/172 44/18639 0.0227272727272727 2.46286997885835 0.335279644722618 0.53504556544585 GO:0043014 alpha-tubulin binding 1/172 44/18639 0.0227272727272727 2.46286997885835 0.335279644722618 0.53504556544585 GO:0046915 transition metal ion transmembrane transporter activity 1/172 45/18639 0.0222222222222222 2.40813953488372 0.341428173956697 0.542965637750581 GO:0030291 protein serine/threonine kinase inhibitor activity 1/172 46/18639 0.0217391304347826 2.35578867542973 0.347520158149418 0.550389885994422 GO:0051087 protein-folding chaperone binding 2/172 134/18639 0.0149253731343284 1.61740715029504 0.35122761172852 0.550389885994422 GO:0140789 histone phosphatase activity 2/172 136/18639 0.0147058823529412 1.59362175102599 0.357899697292109 0.550389885994422 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 1/172 48/18639 0.0208333333333333 2.25763081395349 0.359536554727608 0.550389885994422 GO:0140693 molecular condensate scaffold activity 1/172 48/18639 0.0208333333333333 2.25763081395349 0.359536554727608 0.550389885994422 GO:0005004 GPI-linked ephrin receptor activity 1/172 49/18639 0.0204081632653061 2.21155671570954 0.365461987065129 0.550389885994422 GO:0005008 hepatocyte growth factor receptor activity 1/172 49/18639 0.0204081632653061 2.21155671570954 0.365461987065129 0.550389885994422 GO:0005009 insulin receptor activity 1/172 49/18639 0.0204081632653061 2.21155671570954 0.365461987065129 0.550389885994422 GO:0005011 macrophage colony-stimulating factor receptor activity 1/172 49/18639 0.0204081632653061 2.21155671570954 0.365461987065129 0.550389885994422 GO:0005018 platelet-derived growth factor alpha-receptor activity 1/172 49/18639 0.0204081632653061 2.21155671570954 0.365461987065129 0.550389885994422 GO:0005020 stem cell factor receptor activity 1/172 49/18639 0.0204081632653061 2.21155671570954 0.365461987065129 0.550389885994422 GO:0008288 boss receptor activity 1/172 49/18639 0.0204081632653061 2.21155671570954 0.365461987065129 0.550389885994422 GO:0035254 glutamate receptor binding 1/172 49/18639 0.0204081632653061 2.21155671570954 0.365461987065129 0.550389885994422 GO:0036332 placental growth factor receptor activity 1/172 49/18639 0.0204081632653061 2.21155671570954 0.365461987065129 0.550389885994422 GO:0038062 protein tyrosine kinase collagen receptor activity 1/172 49/18639 0.0204081632653061 2.21155671570954 0.365461987065129 0.550389885994422 GO:0060175 brain-derived neurotrophic factor receptor activity 1/172 49/18639 0.0204081632653061 2.21155671570954 0.365461987065129 0.550389885994422 GO:0004713 protein tyrosine kinase activity 2/172 140/18639 0.0142857142857143 1.54808970099668 0.371168607630334 0.550389885994422 GO:0005006 epidermal growth factor receptor activity 1/172 50/18639 0.02 2.16732558139535 0.371332914349949 0.550389885994422 GO:0005007 fibroblast growth factor receptor activity 1/172 50/18639 0.02 2.16732558139535 0.371332914349949 0.550389885994422 GO:0005017 platelet-derived growth factor receptor activity 1/172 50/18639 0.02 2.16732558139535 0.371332914349949 0.550389885994422 GO:0005019 platelet-derived growth factor beta-receptor activity 1/172 50/18639 0.02 2.16732558139535 0.371332914349949 0.550389885994422 GO:0005010 insulin-like growth factor receptor activity 1/172 51/18639 0.0196078431372549 2.12482900136799 0.377149835041315 0.551051459940495 GO:0005030 neurotrophin receptor activity 1/172 51/18639 0.0196078431372549 2.12482900136799 0.377149835041315 0.551051459940495 GO:0005272 sodium channel activity 1/172 51/18639 0.0196078431372549 2.12482900136799 0.377149835041315 0.551051459940495 GO:0016830 carbon-carbon lyase activity 1/172 51/18639 0.0196078431372549 2.12482900136799 0.377149835041315 0.551051459940495 GO:0005080 protein kinase C binding 1/172 52/18639 0.0192307692307692 2.08396690518784 0.38291324306654 0.551051459940495 GO:0005261 monoatomic cation channel activity 4/172 341/18639 0.0117302052785924 1.2711586987656 0.386035417739009 0.551051459940495 GO:0003779 actin binding 5/172 443/18639 0.0112866817155756 1.22309570056171 0.38860364207084 0.551051459940495 GO:0004864 protein phosphatase inhibitor activity 1/172 53/18639 0.0188679245283019 2.04464677490127 0.388623627861965 0.551051459940495 GO:0005003 ephrin receptor activity 1/172 53/18639 0.0188679245283019 2.04464677490127 0.388623627861965 0.551051459940495 GO:0005005 transmembrane-ephrin receptor activity 1/172 53/18639 0.0188679245283019 2.04464677490127 0.388623627861965 0.551051459940495 GO:0005246 calcium channel regulator activity 1/172 53/18639 0.0188679245283019 2.04464677490127 0.388623627861965 0.551051459940495 GO:0005544 calcium-dependent phospholipid binding 1/172 53/18639 0.0188679245283019 2.04464677490127 0.388623627861965 0.551051459940495 GO:0038064 collagen receptor activity 1/172 53/18639 0.0188679245283019 2.04464677490127 0.388623627861965 0.551051459940495 GO:0051018 protein kinase A binding 1/172 53/18639 0.0188679245283019 2.04464677490127 0.388623627861965 0.551051459940495 GO:0015485 cholesterol binding 1/172 54/18639 0.0185185185185185 2.00678294573643 0.394281474413549 0.555633585481247 GO:0140463 chromatin-protein adaptor activity 1/172 54/18639 0.0185185185185185 2.00678294573643 0.394281474413549 0.555633585481247 GO:0098632 cell-cell adhesion mediator activity 1/172 55/18639 0.0181818181818182 1.97029598308668 0.399887263297104 0.560086747981877 GO:0140313 molecular sequestering activity 1/172 55/18639 0.0181818181818182 1.97029598308668 0.399887263297104 0.560086747981877 GO:0046873 metal ion transmembrane transporter activity 5/172 450/18639 0.0111111111111111 1.20406976744186 0.401416932132972 0.560515106453967 GO:0019212 phosphatase inhibitor activity 1/172 56/18639 0.0178571428571429 1.93511212624585 0.40544147071816 0.562703616936112 GO:0170055 lipid transmembrane transporter activity 1/172 56/18639 0.0178571428571429 1.93511212624585 0.40544147071816 0.562703616936112 GO:0001786 phosphatidylserine binding 1/172 59/18639 0.0169491525423729 1.83671659440284 0.421799301534625 0.578395449409755 GO:0004879 nuclear receptor activity 1/172 59/18639 0.0169491525423729 1.83671659440284 0.421799301534625 0.578395449409755 GO:0015459 potassium channel regulator activity 1/172 59/18639 0.0169491525423729 1.83671659440284 0.421799301534625 0.578395449409755 GO:0070888 E-box binding 1/172 59/18639 0.0169491525423729 1.83671659440284 0.421799301534625 0.578395449409755 GO:0098531 ligand-modulated transcription factor activity 1/172 60/18639 0.0166666666666667 1.80610465116279 0.427151859130752 0.583986720841446 GO:0019905 syntaxin binding 1/172 61/18639 0.0163934426229508 1.77649637819291 0.432455152108281 0.589477558528549 GO:0015079 potassium ion transmembrane transporter activity 2/172 160/18639 0.0125 1.35457848837209 0.4356972627127 0.592134558820228 GO:0015179 L-amino acid transmembrane transporter activity 1/172 62/18639 0.0161290322580645 1.7478432108027 0.437709631268437 0.593109500357823 GO:1901682 sulfur compound transmembrane transporter activity 1/172 63/18639 0.0158730158730159 1.72009966777409 0.442915743311384 0.598393541110955 GO:0015081 sodium ion transmembrane transporter activity 2/172 164/18639 0.0121951219512195 1.3215399886557 0.448183473871591 0.603367911959157 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 3/172 268/18639 0.0111940298507463 1.21305536272128 0.450701574933396 0.603367911959157 GO:0008514 organic anion transmembrane transporter activity 3/172 269/18639 0.0111524163568773 1.20854586323161 0.453108224002422 0.603367911959157 GO:0120013 lipid transfer activity 1/172 65/18639 0.0153846153846154 1.66717352415027 0.45318463256321 0.603367911959157 GO:0160215 deacylase activity 1/172 65/18639 0.0153846153846154 1.66717352415027 0.45318463256321 0.603367911959157 GO:0016500 protein-hormone receptor activity 1/172 67/18639 0.0149253731343284 1.61740715029504 0.463265312844953 0.610103813402763 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/172 67/18639 0.0149253731343284 1.61740715029504 0.463265312844953 0.610103813402763 GO:0042054 histone methyltransferase activity 1/172 67/18639 0.0149253731343284 1.61740715029504 0.463265312844953 0.610103813402763 GO:0030414 peptidase inhibitor activity 2/172 169/18639 0.0118343195266272 1.28244117242328 0.463572329834414 0.610103813402763 GO:0005548 phospholipid transporter activity 1/172 68/18639 0.0147058823529412 1.59362175102599 0.468236148844882 0.612720446202731 GO:0032934 sterol binding 1/172 68/18639 0.0147058823529412 1.59362175102599 0.468236148844882 0.612720446202731 GO:0008017 microtubule binding 3/172 276/18639 0.0108695652173913 1.17789433771486 0.469831642469354 0.61305667307967 GO:0016279 protein-lysine N-methyltransferase activity 1/172 69/18639 0.0144927536231884 1.57052578361982 0.473161213860157 0.615007709330989 GO:0001217 DNA-binding transcription repressor activity 3/172 278/18639 0.0107913669064748 1.1694202777313 0.474568463814982 0.615007709330989 GO:0015631 tubulin binding 4/172 385/18639 0.0103896103896104 1.12588341890667 0.476477171178978 0.615007709330989 GO:0008028 monocarboxylic acid transmembrane transporter activity 1/172 70/18639 0.0142857142857143 1.54808970099668 0.478040926903563 0.615007709330989 GO:0016278 lysine N-methyltransferase activity 1/172 70/18639 0.0142857142857143 1.54808970099668 0.478040926903563 0.615007709330989 GO:0004721 phosphoprotein phosphatase activity 2/172 175/18639 0.0114285714285714 1.23847176079734 0.481704650878299 0.617757184507991 GO:0140299 molecular sensor activity 1/172 71/18639 0.0140845070422535 1.52628562070095 0.482875703174369 0.617757184507991 GO:0004252 serine-type endopeptidase activity 2/172 176/18639 0.0113636363636364 1.23143498942918 0.484690250591496 0.618351350336783 GO:0005319 lipid transporter activity 2/172 178/18639 0.0112359550561798 1.21759864123334 0.490629630148925 0.622996508284947 GO:0004521 RNA endonuclease activity 1/172 73/18639 0.0136986301369863 1.48446957629818 0.492412087334391 0.622996508284947 GO:0043539 protein serine/threonine kinase activator activity 1/172 73/18639 0.0136986301369863 1.48446957629818 0.492412087334391 0.622996508284947 GO:0016853 isomerase activity 2/172 180/18639 0.0111111111111111 1.20406976744186 0.496526195411288 0.625490231163485 GO:0031491 nucleosome binding 1/172 74/18639 0.0135135135135135 1.46440917661848 0.497114506863556 0.625490231163485 GO:0017022 myosin binding 1/172 76/18639 0.0131578947368421 1.42587209302326 0.50638980228927 0.634197917457955 GO:0008237 metallopeptidase activity 2/172 184/18639 0.0108695652173913 1.17789433771486 0.508189160932466 0.634197917457955 GO:0061135 endopeptidase regulator activity 2/172 184/18639 0.0108695652173913 1.17789433771486 0.508189160932466 0.634197917457955 GO:0008234 cysteine-type peptidase activity 2/172 187/18639 0.0106951871657754 1.15899763710981 0.51682095685281 0.6432173865179 GO:0046943 carboxylic acid transmembrane transporter activity 2/172 188/18639 0.0106382978723404 1.15283275606136 0.519676000032878 0.645017907899886 GO:0005342 organic acid transmembrane transporter activity 2/172 189/18639 0.0105820105820106 1.14673311184939 0.522519864948816 0.646794859855561 GO:0019902 phosphatase binding 2/172 190/18639 0.0105263157894737 1.1406976744186 0.525352513791395 0.648548386297733 GO:0001618 virus receptor activity 1/172 81/18639 0.0123456790123457 1.33785529715762 0.528840628719746 0.649353908722906 GO:0015101 organic cation transmembrane transporter activity 1/172 81/18639 0.0123456790123457 1.33785529715762 0.528840628719746 0.649353908722906 GO:0140272 exogenous protein binding 1/172 82/18639 0.0121951219512195 1.3215399886557 0.533207446903829 0.652965269203085 GO:0008236 serine-type peptidase activity 2/172 194/18639 0.0103092783505155 1.11717813473987 0.536570248953122 0.655331130721413 GO:0004860 protein kinase inhibitor activity 1/172 84/18639 0.0119047619047619 1.29007475083056 0.54182073318141 0.659983765417781 GO:0017171 serine hydrolase activity 2/172 198/18639 0.0101010101010101 1.0946088794926 0.547605916575556 0.665261299181975 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1/172 86/18639 0.0116279069767442 1.26007301243916 0.550275993601389 0.666736521347715 GO:0016829 lyase activity 2/172 200/18639 0.01 1.08366279069767 0.553054936324802 0.668335516719682 GO:0003727 single-stranded RNA binding 1/172 89/18639 0.0112359550561798 1.21759864123334 0.56266887715129 0.677761226630484 GO:0003714 transcription corepressor activity 2/172 204/18639 0.00980392156862745 1.06241450068399 0.563814470188241 0.677761226630484 GO:0019210 kinase inhibitor activity 1/172 90/18639 0.0111111111111111 1.20406976744186 0.566723915055871 0.679475269883741 GO:0005516 calmodulin binding 2/172 207/18639 0.00966183574879227 1.04701718907988 0.571762375132274 0.683726286711701 GO:0043178 alcohol binding 1/172 92/18639 0.0108695652173913 1.17789433771486 0.574722185428328 0.685475939911912 GO:0051015 actin filament binding 2/172 209/18639 0.00956937799043062 1.0369978858351 0.57700279387428 0.686408518427066 GO:0051219 phosphoprotein binding 1/172 93/18639 0.010752688172043 1.1652288072018 0.578666100029413 0.686603818169614 GO:0004867 serine-type endopeptidase inhibitor activity 1/172 95/18639 0.0105263157894737 1.1406976744186 0.586445170148617 0.692247133835223 GO:0008276 protein methyltransferase activity 1/172 95/18639 0.0105263157894737 1.1406976744186 0.586445170148617 0.692247133835223 GO:0005216 monoatomic ion channel activity 4/172 448/18639 0.00892857142857143 0.967556063122924 0.595872583076751 0.700675591029956 GO:0008170 N-methyltransferase activity 1/172 98/18639 0.0102040816326531 1.10577835785477 0.597846832408073 0.700675591029956 GO:0045296 cadherin binding 3/172 334/18639 0.00898203592814371 0.973349812003899 0.598175013302866 0.700675591029956 GO:0008238 exopeptidase activity 1/172 102/18639 0.00980392156862745 1.06241450068399 0.612564315457717 0.713879024121208 GO:0015171 amino acid transmembrane transporter activity 1/172 102/18639 0.00980392156862745 1.06241450068399 0.612564315457717 0.713879024121208 GO:0000149 SNARE binding 1/172 106/18639 0.00943396226415094 1.02232338745064 0.626746204216002 0.728552694240936 GO:0005496 steroid binding 1/172 108/18639 0.00925925925925926 1.00339147286822 0.633642384943016 0.734704334946586 GO:0004620 phospholipase activity 1/172 109/18639 0.00917431192660551 0.994186046511628 0.6370428225767 0.736781850353861 GO:1902936 phosphatidylinositol bisphosphate binding 1/172 111/18639 0.00900900900900901 0.976272784412319 0.643749845195032 0.742663549368575 GO:0001221 transcription coregulator binding 1/172 115/18639 0.00869565217391304 0.942315470171891 0.656796449820859 0.752031935044883 GO:0035401 histone H3Y41 kinase activity 1/172 115/18639 0.00869565217391304 0.942315470171891 0.656796449820859 0.752031935044883 GO:0140801 histone H2AXY142 kinase activity 1/172 115/18639 0.00869565217391304 0.942315470171891 0.656796449820859 0.752031935044883 GO:1990782 protein tyrosine kinase binding 1/172 117/18639 0.00854700854700855 0.926207513416816 0.663140493266653 0.757402358893085 GO:0016755 aminoacyltransferase activity 4/172 496/18639 0.00806451612903226 0.87392160540135 0.675231121481912 0.76766813527232 GO:0004540 RNA nuclease activity 1/172 121/18639 0.00826446280991736 0.895589083221218 0.675480913787653 0.76766813527232 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/172 122/18639 0.00819672131147541 0.888248189096454 0.678495131458488 0.769185074772246 GO:0005267 potassium channel activity 1/172 124/18639 0.00806451612903226 0.87392160540135 0.684440315659967 0.774009048326579 GO:0004519 endonuclease activity 1/172 127/18639 0.0078740157480315 0.853277787950925 0.693153762726676 0.781932077164575 GO:0031490 chromatin DNA binding 1/172 128/18639 0.0078125 0.846611555232558 0.696004754127443 0.783219109067246 GO:0016298 lipase activity 1/172 130/18639 0.00769230769230769 0.833586762075134 0.701627968569643 0.785686087053536 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1/172 130/18639 0.00769230769230769 0.833586762075134 0.701627968569643 0.785686087053536 GO:0005262 calcium channel activity 1/172 131/18639 0.00763358778625954 0.82722350434937 0.704400673167731 0.786867093441027 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 1/172 132/18639 0.00757575757575758 0.82095665961945 0.707147760060704 0.788013805615092 GO:0015297 antiporter activity 1/172 135/18639 0.00740740740740741 0.802713178294574 0.71523765695267 0.792267828914022 GO:0005096 GTPase activator activity 2/172 271/18639 0.00738007380073801 0.799751137046254 0.716533525689268 0.792267828914022 GO:0044325 transmembrane transporter binding 1/172 136/18639 0.00735294117647059 0.796810875512996 0.717884604802007 0.792267828914022 GO:0099094 ligand-gated monoatomic cation channel activity 1/172 136/18639 0.00735294117647059 0.796810875512996 0.717884604802007 0.792267828914022 GO:0016922 nuclear receptor binding 1/172 137/18639 0.0072992700729927 0.790994737735529 0.720507090235399 0.793250594538012 GO:0070851 growth factor receptor binding 1/172 139/18639 0.00719424460431655 0.779613518487536 0.725679570863072 0.797029360804046 GO:0019903 protein phosphatase binding 1/172 144/18639 0.00694444444444444 0.752543604651163 0.738198164560105 0.808839137245282 GO:0015085 calcium ion transmembrane transporter activity 1/172 147/18639 0.00680272108843537 0.73718557190318 0.745434958397707 0.813108488946688 GO:0015291 secondary active transmembrane transporter activity 2/172 287/18639 0.00696864111498258 0.755165707803258 0.745645339208753 0.813108488946688 GO:0019842 vitamin binding 1/172 150/18639 0.00666666666666667 0.722441860465116 0.752472841912192 0.818604659372408 GO:0004866 endopeptidase inhibitor activity 1/172 161/18639 0.0062111801242236 0.673082478694208 0.776662900130273 0.842918502984988 GO:0004842 ubiquitin-protein transferase activity 3/172 449/18639 0.0066815144766147 0.72405086238152 0.787051962395488 0.850103221056829 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1/172 167/18639 0.00598802395209581 0.648899874669266 0.788851242247057 0.850103221056829 GO:0016874 ligase activity 1/172 167/18639 0.00598802395209581 0.648899874669266 0.788851242247057 0.850103221056829 GO:0043021 ribonucleoprotein complex binding 1/172 177/18639 0.00564971751412429 0.612238864800946 0.80771284161063 0.868386106708142 GO:0003924 GTPase activity 2/172 331/18639 0.00604229607250755 0.654781142415513 0.81284202062481 0.871853970599914 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 1/172 181/18639 0.00552486187845304 0.598708724142362 0.814779612095393 0.871890332569369 GO:1901981 phosphatidylinositol phosphate binding 1/172 185/18639 0.00540540540540541 0.585763670647392 0.821588125385977 0.874823577330972 GO:0019787 ubiquitin-like protein transferase activity 3/172 479/18639 0.00626304801670146 0.678703209205224 0.822238541815962 0.874823577330972 GO:0015276 ligand-gated monoatomic ion channel activity 1/172 186/18639 0.00537634408602151 0.5826144036009 0.823251008361679 0.874823577330972 GO:0022834 ligand-gated channel activity 1/172 188/18639 0.00531914893617021 0.576416378030678 0.826530687541509 0.876275590032433 GO:0030695 GTPase regulator activity 3/172 489/18639 0.00613496932515337 0.664823797974033 0.832820896837929 0.879960479422303 GO:0060589 nucleoside-triphosphatase regulator activity 3/172 490/18639 0.00612244897959184 0.663467014712862 0.833849013251702 0.879960479422303 GO:0003712 transcription coregulator activity 3/172 495/18639 0.00606060606060606 0.65676532769556 0.838908993452393 0.881304910492929 GO:0061630 ubiquitin protein ligase activity 2/172 353/18639 0.0056657223796034 0.613973252519929 0.840142457650021 0.881304910492929 GO:0005543 phospholipid binding 3/172 497/18639 0.00603621730382294 0.654122408871836 0.840895733374258 0.881304910492929 GO:0008168 methyltransferase activity 1/172 204/18639 0.00490196078431373 0.531207250341997 0.850680527131467 0.889524386817836 GO:0046982 protein heterodimerization activity 2/172 369/18639 0.00542005420054201 0.5873511060692 0.857689274076117 0.89481022215686 GO:0061659 ubiquitin-like protein ligase activity 2/172 372/18639 0.00537634408602151 0.5826144036009 0.860777984549498 0.895991629371977 GO:0016741 transferase activity, transferring one-carbon groups 1/172 215/18639 0.00465116279069767 0.504029204975663 0.865313834270234 0.898670603391762 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 1/172 229/18639 0.00436681222707424 0.473215192444399 0.881893375565181 0.912895128110208 GO:0005085 guanyl-nucleotide exchange factor activity 1/172 230/18639 0.00434782608695652 0.471157735085945 0.882996816054197 0.912895128110208 GO:0016887 ATP hydrolysis activity 2/172 417/18639 0.00479616306954436 0.519742345658357 0.900323139782347 0.928711707252962 GO:0003713 transcription coactivator activity 1/172 256/18639 0.00390625 0.423305777616279 0.908350835424845 0.934886927246245 GO:0003730 mRNA 3'-UTR binding 1/172 262/18639 0.00381679389312977 0.413611752174685 0.913377720955491 0.937952906272679 GO:0031267 small GTPase binding 1/172 283/18639 0.00353356890459364 0.382919714027447 0.928908102019033 0.950323674895404 GO:0035091 phosphatidylinositol binding 1/172 284/18639 0.00352112676056338 0.381571405175237 0.929574249679347 0.950323674895404 GO:0051020 GTPase binding 1/172 315/18639 0.00317460317460317 0.344019933554817 0.947413660800559 0.965749694324347 GO:0022836 gated channel activity 1/172 318/18639 0.00314465408805031 0.340774462483545 0.948880704030472 0.965749694324347 GO:0141003 histone H2AX kinase activity 1/172 354/18639 0.00282485875706215 0.306119432400473 0.963611003231857 0.974451381884605 GO:0140996 histone H3 kinase activity 1/172 357/18639 0.00280112044817927 0.303547000195427 0.96462832116786 0.974451381884605 GO:0035173 histone kinase activity 1/172 360/18639 0.00277777777777778 0.301017441860465 0.965617358952688 0.974451381884605 GO:0106310 protein serine kinase activity 1/172 361/18639 0.00277008310249307 0.300183598531212 0.965940889466399 0.974451381884605 GO:0140098 catalytic activity, acting on RNA 1/172 387/18639 0.00258397932816537 0.280016224986479 0.973368244503148 0.978590196291327 GO:0019001 guanyl nucleotide binding 1/172 400/18639 0.0025 0.270915697674419 0.976453536474097 0.978590196291327 GO:0032561 guanyl ribonucleotide binding 1/172 400/18639 0.0025 0.270915697674419 0.976453536474097 0.978590196291327 GO:0004674 protein serine/threonine kinase activity 1/172 433/18639 0.0023094688221709 0.250268542886299 0.982780856080429 0.982780856080429