category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	39/409	233/9376	3.83709875442039	COL1A1/COL3A1/COL1A2/COL6A2/COL5A2/DCN/COL6A1/FN1/ITGA2/TPM2/MYL9/TPM1/ACTB/FBLN2/ITGA3/ACTG1/COL5A1/ITGB1/DSG2/THBS2/FBN1/NEBL/SPTBN1/ITGB5/COL4A5/ITGA11/COL4A1/SDC4/FLNC/FHL2/SGCB/VCAN/NID2/PDLIM1/COL6A3/DIAPH1/ANK2/PDLIM4/CAPZA2	9.36551709754293
NA	NA	hsa04518	Integrin signaling	31/409	154/9376	4.61461277109199	COL1A1/COL1A2/COL6A2/COL6A1/FN1/VEGFC/ITGA2/EGFR/PTK2/PDGFRA/FRAS1/ACTB/ITGA3/ACTG1/ITGB1/THBS2/FBN1/LAMA4/VCAM1/ITGB5/COL4A5/PARVA/ITGA11/COL4A1/LAMC1/LAMB1/LAMC2/PDGFD/COL6A3/FREM1/LAMB2	9.65902494150829
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	22/409	89/9376	5.66665750940908	COL1A1/COL1A2/COL6A2/COL6A1/FN1/ITGA2/FRAS1/ITGA3/ITGB1/THBS2/LAMA4/ITGB5/COL4A5/ITGA11/COL4A1/SDC4/LAMC1/LAMB1/LAMC2/COL6A3/FREM1/LAMB2	9.44684776122979
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	33/409	203/9376	3.7265949630843	COL1A1/COL1A2/COL6A2/COL6A1/FN1/VEGFC/ITGA2/EGFR/PTK2/PDGFRA/MYL9/ACTB/ITGA3/ACTG1/ITGB1/THBS2/LAMA4/ITGB5/COL4A5/CAV2/PARVA/ITGA11/COL4A1/LAMC1/CAV1/LAMB1/LAMC2/PDGFD/COL6A3/DIAPH1/LAMB2/PRKCA/PPP1CB	8.38757965542879
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	31/409	204/9376	3.48358022915768	COL1A1/COL1A2/DCN/FN1/ITGA2/EGFR/PTK2/LUM/ACTB/CTTN/MMP2/ACTG1/ITGB1/TWIST2/FGF2/GPC1/TWIST1/WNT2/ITGB5/CAV2/SDC4/CAV1/PTCH1/NRAS/RRAS/GPC3/ARHGEF12/ANK2/PRKCA/PPP1CB/HSPB2	7.65922736759988
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	31/409	232/9376	3.0631481325352	BDKRB1/FN1/ITGA2/EGFR/PTK2/PDGFRA/MYL9/FGF7/ACTB/ITGA3/ACTG1/ITGB1/FGF2/ENAH/C7/TMSB4X/NCKAP1/PFN2/ITGB5/FGD1/ITGA11/ARPC1B/PDGFD/NRAS/RRAS/DIAPH1/PFN1/ARHGEF12/ACTR3C/BDKRB2/PPP1CB	6.79563433875851
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	38/409	362/9376	2.40640829945022	COL1A1/COL1A2/COL6A2/COL6A1/FN1/VEGFC/GNG11/ITGA2/EGFR/PTK2/PDGFRA/MAGI1/FGF7/OSMR/ITGA3/ITGB1/THBS2/FGF2/LAMA4/ITGB5/COL4A5/ITGA11/COL4A1/ANGPT1/LAMC1/LAMB1/LAMC2/PDGFD/NRAS/MAGI2/GHR/COL6A3/EFNA5/IFNAR1/CSH1/LAMB2/PRKCA/EPOR	5.8281488668111
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	15/409	86/9376	3.99840791493717	CDH2/GJA1/CACNA2D1/ITGA2/ACTB/ITGA3/ACTG1/ITGB1/DSG2/ITGB5/CACNA1C/ITGA11/CACNG8/SGCB/RYR2	5.96562282275155
NA	NA	hsa04517	IgSF CAM signaling	30/409	299/9376	2.30008749621804	CDH2/CLMP/PTK2/PARD3/SLIT2/MAGI1/CADM3/MYL9/ACTB/ACTG1/ROBO1/ITGB1/MPDZ/SLIT3/TJP1/PTPRD/UNC5C/MYL6/SPTBN1/ROBO2/ARPC1B/KIRREL1/NFASC/DYNLL2/MAGI2/DYNLL1/ACTR3C/ANK2/PRKCA/PLXNA4	4.87933588459843
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	14/409	88/9376	3.64703267392754	BDKRB1/SERPINE2/SERPINE1/C1R/C1S/CFB/C7/CLU/F13A1/CD46/PROS1/PLAT/BDKRB2/CFD	5.32798805039449
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	13/409	78/9376	3.82070089649552	FN1/PTK2/ACTB/CTTN/ACTG1/ITGB1/DNM1/CAV2/ARPC1B/CAV1/ELMO1/ACTR3C/DNM2	5.34236152898932
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	18/409	142/9376	2.90588518888391	PTK2/ACTB/MMP2/ACTG1/GPC1/CCL2/VCAM1/MGST1/BMPR1A/CAV2/SDC4/TNFRSF1A/SQSTM1/CAV1/MAP2K5/GSTP1/PLAT/NQO1	4.8873076643156
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	14/409	93/9376	3.45095564844756	FN1/ITGA2/PTK2/ITGA3/ITGB1/LAMA4/COL4A5/COL4A1/LAMC1/LAMB1/MAX/LAMC2/RARB/LAMB2	5.07290184017733
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	31/409	333/9376	2.13408518542993	COL1A1/COL1A2/COL6A2/COL6A1/FN1/ITGA2/EGFR/PTK2/PARD3/MAGI1/ITGA3/ITGB1/THBS2/LAMA4/WNT2/PKM/ITGB5/COL4A5/ITGA11/COL4A1/TNFRSF1A/LAMC1/LAMB1/ATP6V0E1/LAMC2/NRAS/PSMC1/IRF9/COL6A3/IFNAR1/LAMB2	4.50023544489633
NA	NA	hsa04519	Cadherin signaling	35/409	404/9376	1.98600789174272	CDH2/CDH11/PCDH7/GJA1/EGFR/PTK2/PDGFRA/ACTB/TEAD1/ACTG1/YAP1/DSG2/ENAH/MPDZ/TJP1/NCKAP1/WNT2/PRICKLE2/MYO1B/FAT1/KRT19/PCDH10/LIMA1/ARPC1B/WWTR1/PCDH18/LRP6/NRAS/PRICKLE1/RRAS/KRT8/ACTR3C/PPP1CB/LATS1/PCDHB14	4.32663389619214
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	14/409	99/9376	3.24180682126892	CACNA2D1/ITGA2/TPM2/TPM1/ACTB/ITGA3/ACTG1/ITGB1/ITGB5/CACNA1C/ITGA11/CACNG8/SGCB/RYR2	4.78889938516958
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	14/409	101/9376	3.17761262678835	COL1A1/COL3A1/COL1A2/FN1/VEGFC/SERPINE1/MMP2/CCL2/VCAM1/COL4A5/COL4A1/NRAS/DIAPH1/PRKCA	4.69902830645467
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/409	103/9376	3.11591141073421	COL1A1/COL3A1/COL1A2/FN1/PTK2/LAMA4/COL4A5/COL4A1/PRDX1/LAMC1/LAMB1/LAMC2/LAMB2/PRKCA	4.61136682052429
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	20/409	184/9376	2.49176145423621	PTK2/PARD3/SLIT2/MYL9/ROBO1/ITGB1/ENAH/SLIT3/UNC5C/ROBO2/EPHA3/PTCH1/SEMA6D/NRAS/RRAS/EFNA5/ARHGEF12/PRKCA/PLXNA4/SEMA5A	4.36442457157683
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	14/409	105/9376	3.05656071719641	CACNA2D1/ITGA2/TPM2/TPM1/ACTB/ITGA3/ACTG1/ITGB1/ITGB5/CACNA1C/ITGA11/CACNG8/SGCB/RYR2	4.52581296606075
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	21/409	212/9376	2.27079392904922	VEGFC/EGFR/PDGFRA/PARD3/MAGI1/FGF7/ACTB/ACTG1/ITGB1/FGF2/ENAH/PFN2/PRKD1/ANGPT1/PDGFD/NRAS/RRAS/MAGI2/EFNA5/PFN1/PRKCA	3.99690870924168
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	13/409	103/9376	2.89334630996748	COL1A1/COL3A1/COL1A2/COL6A2/COL5A2/COL6A1/DPP4/COL8A1/COL5A1/COL14A1/COL4A5/COL4A1/COL6A3	4.12631375267104
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	20/409	205/9376	2.23650784185103	COL1A1/COL3A1/COL1A2/MT-CO2/MT-ND4/MT-CYB/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/MMP2/MT-ND3/GAPDH/MT-ND5/GFPT2/UQCRQ/MT-ND2/RYR2/PRKCA/PPP1CB	3.82286679934177
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	24/409	275/9376	2.00065792398311	MT-CO2/MT-ND4/MT-CYB/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/MT-ND3/C7/MT-ND5/CACNA1C/CAV2/LAMC1/CAV1/PSMB5/CSNK2A2/PSMD11/PSMC1/PSMB7/UQCRQ/MT-ND2/RYR2/PSMB4/PSMC4	3.59692295827126
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	11/409	87/9376	2.89846274906557	MT-CO2/MT-CYB/CACNA2D1/MT-CO1/TPM2/MT-CO3/TPM1/CACNA1C/CACNG8/UQCRQ/RYR2	3.79927676967985
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	29/409	368/9376	1.80652705432125	MT-CO2/MT-ND4/MT-CYB/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/ACTB/ACTG1/MT-ND3/GPX8/PFN2/DNAH14/MT-ND5/TNFRSF1A/SQSTM1/PSMB5/PSMD11/PSMC1/PSMB7/PFN1/UQCRQ/MT-ND2/RANBP2/UBQLN1/PSMB4/POM121/PSMC4/NUP188	3.37095044320432
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	11/409	93/9376	2.71146515235166	EGFR/PARD3/MYL9/ACTB/ACTG1/TJP1/YES1/SNAI2/PTPRM/CSNK2A2/WASF3	3.54233040743244
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	21/409	250/9376	1.92563325183374	EGFR/PDGFRA/PARD3/EHD2/AGAP1/DNM1/CAV2/ARPC1B/CAV1/AP2S1/SPART/HGS/VPS26A/ACTR3C/WIPF1/ZFYVE9/DNM2/RAB22A/SNX1/CAPZA2/RABEP1	3.16805291579277
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	22/409	268/9376	1.88183775499033	UCHL1/MT-CO2/MT-ND4/MT-CYB/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/MT-ND3/MT-ND5/PSMB5/PSMD11/PSMC1/PSMB7/UBE2J2/UQCRQ/MT-ND2/SLC39A14/PSMB4/UBA1/PSMC4/SLC39A9	3.12801107561276
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	7/409	46/9376	3.48846603593069	PSMB5/PSMD11/PSMC1/PSMB7/PSME1/PSMB4/PSMC4	3.61321262384877
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	19/409	227/9376	1.91876608898894	MT-CO2/MT-ND4/MT-CYB/MT-ATP6/MT-CO1/EGFR/MT-CO3/PTK2/MT-ND1/MT-ND3/MT-ND5/PRKD1/MGST1/AKR1C1/CBR1/NRAS/NQO1/UQCRQ/MT-ND2	2.99264208766785
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/409	89/9376	2.57575341336776	PRKG1/GJA1/EGFR/PDGFRA/TJP1/MAP2K5/PDGFD/NRAS/PRKCA/GUCY1A2	3.18984253189997
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	20/409	248/9376	1.84872624023977	MYL9/ACTB/ACTG1/NCKAP1/PFN2/GAPDH/ARPC1B/TNFRSF1A/AHNAK2/DYNC2H1/DYNLL2/RRAS/PFN1/DYNLL1/DYNLT3/ELMO1/WASF3/ACTR3C/DNM2/CASP4	2.89287295656342
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	33/409	480/9376	1.5760391198044	UCHL1/MT-CO2/MT-ND4/MT-CYB/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/GRIA4/MT-ND3/GPX8/GRIA3/WNT2/DNAH14/MT-ND5/CACNA1C/TNFRSF1A/SQSTM1/PSMB5/CSNK2A2/LRP6/PSMD11/NRAS/PSMC1/PSMB7/UBE2J2/UQCRQ/MT-ND2/RYR2/PSMB4/UBA1/PRKCA/PSMC4	2.76693474550252
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	14/409	154/9376	2.08401867081574	CACNA2D1/EGFR/MYL9/ACTB/ACTG1/MYL6/CACNA1C/MAP2K5/CACNG8/NRAS/RYR2/PRKCA/PPP1CB/GUCY1A2	2.89673169480521
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	23/409	308/9376	1.71187247959864	MT-CO2/MT-ND4/MT-CYB/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/GRIA4/MT-ND3/GPX8/GRIA3/DNAH14/MT-ND5/PSMB5/AP2S1/PSMD11/PSMC1/PSMB7/UQCRQ/MT-ND2/PSMB4/PSMC4/POLR2A	2.71297326260215
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	27/409	388/9376	1.59524109595947	MT-CO2/MT-ND4/MT-CYB/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/MT-ND3/BACE2/GAPDH/WNT2/MT-ND5/CACNA1C/TNFRSF1A/PSMB5/CSNK2A2/LRP6/PSMD11/NRAS/PSMC1/PSMB7/UQCRQ/MT-ND2/SLC39A14/PSMB4/PSMC4/SLC39A9	2.55741345582826
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	12/409	130/9376	2.11608049652059	COL1A1/COL3A1/COL1A2/VEGFC/GNG11/EGFR/MMP2/COL4A5/COL4A1/MMP1/NRAS/PRKCA	2.73661660522324
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/409	73/9376	2.51224168536692	MAP1B/MAP1A/MLLT3/RANBP2/HGS/SUPT4H1/FURIN/CPSF6	2.77009607706155
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	18/409	238/9376	1.73376343202318	EGFR/C1R/C1S/CFB/C7/CCL2/F13A1/TNFRSF1A/RPL29/MMP1/IRF9/IFNAR1/PRKCA/RSL24D1/RPS26/CFD/RPS14/MMP3	2.44873998818101
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/409	61/9376	2.63064651889855	MT2A/MT1E/STEAP1/FTH1/ATP2B4/STEAP2/MT1X	2.72870774069832
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	12/409	138/9376	1.99340916338897	MT-CO2/MT-ND4/MT-CYB/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/MT-ND3/MT-ND5/ATP6V0E1/UQCRQ/MT-ND2	2.5107439984972
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	13/409	157/9376	1.89818261099777	BMP5/PARD3/SERPINE1/ACTB/TEAD1/ACTG1/YAP1/WNT2/BMPR1A/WWTR1/SNAI2/PPP1CB/LATS1	2.42379714073726
Organismal Systems	Immune system	hsa04611	Platelet activation	11/409	126/9376	2.00131951721194	COL1A1/COL3A1/COL1A2/PRKG1/ITGA2/ACTB/ACTG1/ITGB1/ARHGEF12/PPP1CB/GUCY1A2	2.41663351845095
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/409	53/9376	2.59519306177054	DNM1/AP2S1/ATP2B4/BDKRB2/PRKCA/DNM2	2.48712178775419
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	15/409	200/9376	1.71931540342298	ACTB/CTTN/ACTG1/ITGB1/TJP1/NCKAP1/GAPDH/MYO1B/ARPC1B/TNFRSF1A/ARHGEF12/WASF3/ACTR3C/WIPF1/CASP4	2.19599508164923
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	15/409	201/9376	1.71076159544575	MEIS1/PTK2/IGFBP3/GRIA3/MLLT3/RUNX1T1/FUT8/NR4A3/MAX/PBX1/NUPR1/PLAT/WT1/MMP3/ETV1	2.17541767661377
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/409	29/9376	3.16195936261698	TEAD1/YAP1/WWTR1/LATS1	2.49019932682795
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	11/409	138/9376	1.82729173310655	FN1/PTK2/ACTB/ACTG1/ITGB1/CCL2/ARPC1B/ARHGEF12/ELMO1/ACTR3C/WIPF1	2.09089852444851
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/409	59/9376	2.3312751232854	GPX8/MGST1/GSTP1/PGD/GPX4/TXNDC12	2.19068271759647
Cellular Processes	Cell motility	hsa04814	Motor proteins	14/409	194/9376	1.65432409951352	TPM2/MYL9/TPM1/ACTB/ACTG1/MYL6/DNAH14/MYO1B/DYNC2H1/KIF26B/DYNLL2/DYNLL1/DYNLT3/CAPZA2	1.96674857527347
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	11/409	144/9376	1.75115457756045	GRIA3/RORA/PSMB5/PSMD11/PSMC1/KCND3/AFG3L2/PSMB7/PSMB4/PRKCA/PSMC4	1.93993140452173
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	9/409	110/9376	1.87561680373416	DCN/BMP5/GREM1/FBN1/BAMBI/THSD4/BMPR1A/NBL1/ZFYVE9	1.97282239542191
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/409	20/9376	3.43863080684597	DHCR24/MSMO1/DHCR7	2.33152273385069
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/409	97/9376	1.89065611372974	PRKG1/GNG11/GRIA4/GRIA3/CACNA1C/RYR2/PRKCA/GUCY1A2	1.88308116929959
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/409	50/9376	2.29242053789731	THBS2/CCL2/VCAM1/CD81/HBB	1.95688297432781
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	9/409	116/9376	1.77860214147205	PTK2/MYL9/ACTB/MMP2/ACTG1/ITGB1/THY1/VCAM1/PRKCA	1.80203326002938
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/409	99/9376	1.8524610407251	SLC22A3/EGFR/PDGFRA/PDGFD/NRAS/WASF3/SLC22A4/PRKCA	1.82100889116696
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/409	134/9376	1.71076159544575	CALD1/PRKG1/MYL9/MYL6/CACNA1C/EDNRA/ARHGEF12/PRKCA/PPP1CB/GUCY1A2	1.76977101475392
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	12/409	170/9376	1.61817920322163	PARD3/MAGI1/MYL9/ACTB/CTTN/ACTG1/ITGB1/MPDZ/TJP1/MYL6/ARPC1B/ACTR3C	1.73710901117328
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/409	51/9376	2.2474711155856	ACTB/ACTG1/TJP1/ATP6V0E1/PRKCA	1.90772105854461
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/409	37/9376	2.4782924734025	LAMA4/VCAM1/PRKCA/HBB	1.92413149067857
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/409	23/9376	2.99011374508345	PCYOX1/FDPS/IDI1	2.04075118526584
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/409	69/9376	1.99340916338897	GRIA4/GRIA3/CACNA1C/FOSB/PRKCA/PPP1CB	1.76877078944148
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/409	70/9376	1.96493188962627	ACTB/ACTG1/CAV1/SGCB/EIF4G3/EIF4G1	1.73056478743215
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	16/409	253/9376	1.44975211882834	EGFR/PTK2/MYL9/ACTB/CTTN/ACTG1/ITGB1/PFN2/ARPC1B/TNFRSF1A/SQSTM1/DIAPH1/PFN1/ELMO1/ACTR3C/CASP4	1.54877506696415
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	15/409	235/9376	1.46324715184935	PRKG1/MT-CO2/MT-ND4/MT-CYB/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/ACTB/ACTG1/MT-ND3/MT-ND5/NRAS/UQCRQ/MT-ND2	1.53593749291519
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/409	73/9376	1.88418126402519	EGFR/PDGFRA/FGF7/FGF2/PDGFD/NRAS	1.61962672672472
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/409	41/9376	2.23650784185103	EGFR/MMP2/MMP1/NRAS	1.69455375242141
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/409	42/9376	2.1832576551403	FTH1/SLC39A14/SAT2/GPX4	1.64132194837729
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/409	27/9376	2.54713393099701	ELOVL2/FADS1/FADS2	1.71929705979283
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	10/409	149/9376	1.53853727375658	MT-ND4/GNG11/MT-ND1/GRIA4/MT-ND3/GRIA3/MT-ND5/CACNA1C/MT-ND2/PRKCA	1.41514958616731
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	14/409	226/9376	1.42008351905143	PDE10A/MYL9/GRIA4/POPDC3/GLI3/GRIA3/CACNA1C/PDE3A/PTCH1/EDNRA/RRAS/RYR2/ATP2B4/PPP1CB	1.36522119875299
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/409	60/9376	1.91035044824776	PRKG1/GRIA3/NRAS/PRKCA/GUCY1A2	1.51075208736298
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/409	28/9376	2.45616486203283	AKR1B1/CBR1/AKR1B10	1.64798751894944
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/409	14/9376	3.27488648271044	FUT8/CHST1	1.81912749045521
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/409	79/9376	1.74107888954226	SYT1/DNM1/ATP6V0E1/AP2S1/SNAP25/DNM2	1.41263603199307
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/409	154/9376	1.48858476486838	CACNA2D1/TPM2/TPM1/POPDC3/CACNA1C/CACNG8/RYR2/ATP2B4/PRKCA/PPP1CB	1.30560387205155
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/409	80/9376	1.71931540342298	EGFR/PDGFRA/FGF2/PDGFD/NRAS/PRKCA	1.37987581760921
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/409	63/9376	1.81938137928358	SMYD3/PLOD2/PRDM6/HADHA/ALDH2	1.39359080064998
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/409	63/9376	1.81938137928358	PTGDS/PTGIS/CBR1/GPX4/PTGES	1.39359080064998
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	10/409	155/9376	1.47898099219181	ITGA2/ACTB/ACTG1/C1R/ITGB1/THBS2/ITGB5/DYNC2H1/ATP6V0E1/HGS	1.28415907338637
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/409	65/9376	1.76340041376716	AKR1B1/AKR1B10/GPAM/ALDH2/LPIN2	1.31896907583721
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	11/409	178/9376	1.41666437735227	BAMBI/RSPO2/WNT2/PRICKLE2/ROR2/CSNK2A2/CBY1/LRP6/MCC/PRICKLE1/PRKCA	1.19859752884329
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/409	32/9376	2.14914425427873	AKR1B1/AKR1B10/GAA	1.39061474990691
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	17/409	300/9376	1.29903830480848	CACNA2D1/VEGFC/EGFR/PDGFRA/FGF7/FGF2/CACNA1C/TNFRSF1A/ANGPT1/MAP2K5/CACNG8/MAX/PDGFD/NRAS/RRAS/EFNA5/PRKCA	1.12425263255226
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/409	106/9376	1.51386261936615	EGFR/PDGFRA/PDGFD/GSTP1/PLAT/NRAS/MMP3	1.13627590961498
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	7/409	110/9376	1.45881306957102	EGFR/SERPINE1/TIMP1/GAPDH/ANGPT1/ELOB/PRKCA	1.03373609905821
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/409	170/9376	1.34848266935136	EGFR/ACTB/ACTG1/WNT2/MGST1/GSTP1/LRP6/NRAS/NQO1/PRKCA	0.979250647729949
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/409	112/9376	1.43276283618582	ITGB1/LAMA4/TNFRSF1A/LAMC1/LAMB1/LAMC2/LAMB2	0.983973503368835
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/409	93/9376	1.47898099219181	EGFR/MMP2/CACNA1C/MMP14/NRAS/PRKCA	0.991378019524288
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	10/409	173/9376	1.32509857681925	IL33/ACTB/ACTG1/CCL2/TNFRSF1A/HNRNPUL1/IRF9/IFNAR1/FDPS/PRKCA	0.921715978198887
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/409	21/9376	2.1832576551403	ENPP1/ALDH2	1.15928650831856
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/409	57/9376	1.60871616694548	ELOVL2/FADS1/FADS2/HADHA	0.984444678412998
NA	NA	hsa04382	Cornified envelope formation	12/409	217/9376	1.26769799330727	S100A16/S100A13/DSG2/S100A6/TJP1/COL4A5/KRT19/COL4A1/LAMC2/KRT8/KDSR/FURIN	0.852068794664566
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	13/409	238/9376	1.25216247868341	VEGFC/GNG11/EGFR/PDGFRA/FGF7/FGF2/ANGPT1/PDGFD/NRAS/RASA3/RRAS/EFNA5/PRKCA	0.841525099402055
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	9/409	157/9376	1.31412642299846	PTK2/ITGB5/PBX1/PROS1/BSG/MFGE8/ELMO1/TMEM30A/EPOR	0.847688116615712
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/409	79/9376	1.45089907461855	HSD11B1/MGST1/AKR1C1/CBR1/GSTP1	0.859498615581834
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	7/409	119/9376	1.34848266935136	VEGFC/CCL2/VCAM1/MMP14/TNFRSF1A/RHBDF1/MMP3	0.817039853273228
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/409	160/9376	1.28948655256724	CDH2/CADM3/ITGB1/VCAM1/PTPRD/SDC4/NFASC/VCAN/PTPRM	0.788752701984155
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/409	42/9376	1.63744324135522	TDO2/HADHA/ALDH2	0.884211125392666
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/409	24/9376	1.91035044824776	HS3ST3A1/EXT1	0.95364270182143
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	7/409	122/9376	1.31532325944928	PTK2/IGFBP3/CACNA1C/NRAS/GHR/CSH1/PRKCA	0.748677673691949
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	9/409	166/9376	1.24287860488408	PRKG1/MYL9/CACNA1C/PDE3A/EDNRA/ATP2B4/BDKRB2/PPP1CB/GUCY1A2	0.674275214478267
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/409	44/9376	1.5630140031118	DYNC2H1/DYNLL2/DYNLL1	0.799432641941942
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/409	168/9376	1.22808243101642	EGFR/PDGFRA/OSMR/GHR/IRF9/IFNAR1/CSH1/IL24/EPOR	0.637070545320258
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	13/409	254/9376	1.17328610207343	BDKRB1/VEGFC/EGFR/PDGFRA/FGF7/FGF2/CACNA1C/EDNRA/PDGFD/RYR2/ATP2B4/BDKRB2/PRKCA	0.597942281807567
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/409	86/9376	1.33280263831239	CACNA1C/PCLO/SNAP25/RYR2/PRKCA	0.662143067558546
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/409	149/9376	1.23082981900527	EGFR/PDGFRA/DNM1/PDGFD/NRAS/RRAS/PRKCA/DNM2	0.606566599488575
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/409	66/9376	1.38934578054382	HSD11B1/HSD17B2/AKR1C1/HSD17B11	0.67788544170427
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	6/409	108/9376	1.27356696549851	DDX39B/RANBP2/RNPS1/ACIN1/POM121/NUP188	0.610669494369104
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/409	67/9376	1.3686092763566	CACNA1C/NRAS/PRKCA/PPP1CB	0.646659785581613
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/409	47/9376	1.46324715184935	PKM/ME1/ALDH2	0.679935705042821
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/409	28/9376	1.63744324135522	ELOVL2/HADHA	0.721414541156808
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	9/409	174/9376	1.18573476098137	TUSC3/CKAP4/STUB1/UBE2J2/NPLOC4/UBQLN1/SAR1A/DNAJB12/P4HB	0.528141638237093
NA	NA	hsa03272	Virion - Hepatitis viruses	3/409	48/9376	1.43276283618582	DPP4/EGFR/CD81	0.64194824465404
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/409	69/9376	1.32893944225931	CACNA1C/PDE3A/EDNRA/GUCY1A2	0.585678588849126
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/409	10/9376	2.29242053789731	SELENBP1	0.873273902063815
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/409	91/9376	1.2595717241194	GNG11/PDE10A/PDE3A/PDE7B/PRKCA	0.531386884648685
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/409	70/9376	1.30995459308418	HSD11B1/MGST1/CBR1/GSTP1	0.555890535136209
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/409	50/9376	1.37545232273839	P4HA3/SAT2/ALDH2	0.5684807974608
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/409	71/9376	1.29150452839285	EGFR/PDGFRA/PKM/NRAS	0.526550462619564
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/409	93/9376	1.23248416015984	PRKG1/PRH1/ATP2B4/PRKCA/GUCY1A2	0.481187541942658
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/409	31/9376	1.47898099219181	HADHA/ALDH2	0.570470486123982
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/409	116/9376	1.18573476098137	GNG11/GRIA4/GRIA3/CACNA1C/GRIK2/PRKCA	0.429873229219786
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/409	73/9376	1.25612084268346	EGFR/NRAS/RARB/PRKCA	0.469157376387891
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	5/409	95/9376	1.20653712520911	CCL2/ANGPT1/ATP6V0E1/MMP1/MMP3	0.432101975075877
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/409	12/9376	1.91035044824776	NQO1	0.673895006380103
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/409	12/9376	1.91035044824776	CD46	0.673895006380103
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/409	76/9376	1.20653712520911	ANGPTL4/MMP1/ME1/FADS2	0.386088758709251
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/409	76/9376	1.20653712520911	EGFR/PDGFRA/NRAS/PRKCA	0.386088758709251
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	7/409	142/9376	1.13006646234374	TNFRSF11B/TNFRSF1A/SQSTM1/FHL2/FOSB/IRF9/IFNAR1	0.333532587372302
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/409	98/9376	1.16960231525373	ARPC1B/WASF3/ACTR3C/PRKCA/DNM2	0.36044693558188
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	14/409	298/9376	1.07697609162961	IL33/BMP5/CXCL14/OSMR/CCL2/EDA/BMPR1A/TNFRSF11B/TNFRSF1A/GHR/IFNAR1/CSH1/IL24/EPOR	0.288398240655982
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/409	55/9376	1.25041120248944	SAMD8/KDSR/SGPL1	0.397765902734408
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/409	99/9376	1.15778815045319	C1R/C1S/CFB/KRT19/CFD	0.337063644165649
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/409	34/9376	1.34848266935136	NPAS2/RORA	0.434734812798763
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/409	56/9376	1.22808243101642	GLI3/CDON/PTCH1	0.365596136751863
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/409	35/9376	1.30995459308418	AKR1B1/AKR1B10	0.392336867099359
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/409	103/9376	1.11282550383365	DDX39B/RNPS1/ACIN1/PPP1CB/CPSF6	0.24588920984498
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/409	36/9376	1.27356696549851	AKR1B1/AKR1B10	0.35120862492538
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/409	36/9376	1.27356696549851	ENPP1/GAA	0.35120862492538
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/409	150/9376	1.06979625101874	EGFR/FGF7/FGF2/WNT2/LRP6/NRAS/RARB	0.184032577017652
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/409	15/9376	1.52828035859821	AK1	0.437293153855212
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	6/409	128/9376	1.07457212713936	PDE10A/AK1/ENPP1/PDE3A/PDE7B/GUCY1A2	0.181418391870189
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/409	60/9376	1.14621026894866	PTK2/NRAS/PRKCA	0.24264003981461
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/409	83/9376	1.10478098211919	AUTS2/MBD5/MAX/PHC2	0.204770433522105
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/409	38/9376	1.20653712520911	NNMT/ENPP1	0.272449928719008
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/409	16/9376	1.43276283618582	MIF	0.36999489559796
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/409	86/9376	1.06624211064991	EGFR/PTK2/NRAS/PRKCA	0.131795092039246
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/409	63/9376	1.09162882757015	GLI3/WNT2/PTCH1	0.155840850676579
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	7/409	156/9376	1.02865024136418	EGFR/TNFRSF1A/CD81/IFIT1/NRAS/IRF9/IFNAR1	0.0770635180095515
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/409	133/9376	1.03417467875067	GNG11/GRIA4/GRIA3/CACNA1C/PRKCA/PPP1CB	0.0847710362570136
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/409	17/9376	1.34848266935136	CA12	0.307124617866856
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/409	17/9376	1.34848266935136	PCDH7	0.307124617866856
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/409	41/9376	1.11825392092552	GRIA4/GRIA3	0.162059324381561
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/409	65/9376	1.0580402482603	CACNA1C/NRAS/PRKCA	0.10027934387863
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/409	18/9376	1.27356696549851	MAN2B1	0.24810304391381
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/409	18/9376	1.27356696549851	PRDX1	0.24810304391381
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/409	67/9376	1.02645695726745	GAPDH/PKM/ALDH2	0.0464140525241729
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/409	43/9376	1.06624211064991	HADHA/ALDH2	0.0929782705891739
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/409	19/9376	1.20653712520911	IDS	0.192455497319849
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/409	140/9376	0.982465944813133	GNG11/SERPINE1/PLAT/NRAS/RRAS/RYR2	-0.0446404056250238
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/409	44/9376	1.04200933540787	TUSC3/FUT8	0.059649731277942
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/409	44/9376	1.04200933540787	CPE/PTPRN	0.059649731277942
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/409	94/9376	0.975498101232898	CCL2/MMP1/FOSB/MMP3	-0.050987837528228
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	6/409	144/9376	0.955175224123879	MEIS1/FGF2/WNT2/BMPR1A/NRAS/RIF1	-0.115764441861152
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/409	71/9376	0.968628396294638	EGFR/TJP1/ATP6V0E1	-0.0566671555164113
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/409	21/9376	1.09162882757015	CHPF	0.0897725555492188
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/409	47/9376	0.975498101232898	PKM/CACNA1C	-0.035962910395864
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/409	122/9376	0.93951661389234	ACTB/ACTG1/NRAS/MED4/PRKCA	-0.143606789068406
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/409	98/9376	0.935681852202984	PRKD1/CACNA1C/ATP2B4/PRKCA	-0.136691997636082
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/409	22/9376	1.04200933540787	ALDH2	0.0421290994686825
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/409	48/9376	0.955175224123879	HADHA/ALDH2	-0.0664918144180267
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/409	148/9376	0.929359677525937	EGFR/FGF7/FGF2/WNT2/LRP6/NRAS	-0.184992211930658
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/409	99/9376	0.92623052036255	EGFR/PTK2/MMP2/NRAS	-0.157584771501455
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/409	99/9376	0.92623052036255	BDKRB1/BDKRB2/PRKCA/PPP1CB	-0.157584771501455
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/409	49/9376	0.935681852202984	GALNT9/GXYLT2	-0.096401610260536
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/409	100/9376	0.916968215158924	CXCL14/CCL2/TNFRSF1A/IL24	-0.178273877626764
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/409	75/9376	0.916968215158924	GAPDH/PKM/MAT2A	-0.154182076504514
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/409	125/9376	0.916968215158924	TNFRSF1A/NRAS/BDKRB2/PRKCA/SGPL1	-0.199585389961493
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/409	76/9376	0.904902843906833	ACTB/ACTG1/PRKCA	-0.177769216626876
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/409	102/9376	0.898988446234239	RAB27B/RYR2/ATP2B4/PRKCA	-0.219059099940107
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/409	103/9376	0.890260403066917	SERPINE1/CCL2/TNFRSF1A/BDKRB2	-0.239163858008277
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	9/409	227/9376	0.908889200047392	GNG11/EGFR/PTK2/PDGFRA/CCL2/TNFRSF1A/NRAS/ARHGEF12/PRKCA	-0.296769784874531
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/409	78/9376	0.881700206883581	C1R/ITGB1/C1S	-0.224057880230321
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/409	104/9376	0.881700206883581	GPAM/ETNK1/SAMD8/LPIN2	-0.259082244391029
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/409	105/9376	0.873303062056118	VCAM1/EDA/TNFRSF1A/CSNK2A2	-0.278818242375214
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/409	105/9376	0.873303062056118	SQSTM1/CSNK2A2/NRAS/RRAS	-0.278818242375214
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/409	105/9376	0.873303062056118	NRAS/RRAS/IRF9/ARHGEF12	-0.278818242375214
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/409	26/9376	0.881700206883581	FADS2	-0.128999658621382
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	6/409	157/9376	0.876084281998972	SERPINE1/IGFBP3/SQSTM1/NRAS/RRAS/PPP1CB	-0.334393651475446
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	6/409	157/9376	0.876084281998972	MT-CO2/MT-CYB/MT-CO1/MT-CO3/TNFRSF1A/UQCRQ	-0.334393651475446
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/409	54/9376	0.849044643665671	CISD1/MAT2A	-0.237582564358488
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	6/409	158/9376	0.870539444771131	WNT2/TNFRSF1A/LRP6/NRAS/PRKCA/LPIN2	-0.350486556226703
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/409	27/9376	0.849044643665671	HADHA	-0.167753479582947
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/409	56/9376	0.818721620677611	TUSC3/FUT8	-0.290573346055462
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/409	56/9376	0.818721620677611	SAR1A/RAB1B	-0.290573346055462
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/409	28/9376	0.818721620677611	ATP6V0E1	-0.205158436635826
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	8/409	214/9376	0.856979640335443	GNG11/PTK2/TNFRSF1A/AP1S1/NRAS/ELOB/PRKCA/DDB1	-0.451994672679013
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	8/409	216/9376	0.849044643665671	PTK2/CCL2/VCAM1/TNFRSF1A/MMP1/NRAS/PRKCA/MMP3	-0.479348501139832
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/409	59/9376	0.7770917077618	EGFR/NRAS	-0.366807232309771
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	7/409	193/9376	0.831447863486071	GNG11/PTK2/PARD3/CXCL14/CCL2/NRAS/ELMO1	-0.505294221300335
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/409	115/9376	0.797363665355586	GNG11/CACNA1C/NRAS/PRKCA	-0.466939922169323
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/409	115/9376	0.797363665355586	GNG11/CACNA1C/NRAS/PRKCA	-0.466939922169323
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	4/409	115/9376	0.797363665355586	EGFR/MMP14/LRP6/PRKCA	-0.466939922169323
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	6/409	168/9376	0.818721620677611	IL33/TNFRSF1A/SQSTM1/FTH1/IRF9/IFNAR1	-0.506339376755305
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	5/409	142/9376	0.807190330245532	STUB1/ELOB/UBE2J2/UBA1/DDB1	-0.49442651752648
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/409	31/9376	0.739490496095907	PGD	-0.310269062352628
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/409	31/9376	0.739490496095907	ALDH2	-0.310269062352628
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/409	116/9376	0.790489840654245	GAPDH/PKM/ME1/PGD	-0.484900124653277
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/409	89/9376	0.772726024010329	GNG11/CACNA1C/PRKCA	-0.460077185209094
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/409	90/9376	0.764140179299103	EGFR/CSNK2A2/NRAS	-0.480158461385652
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/409	32/9376	0.71638141809291	HADHA	-0.343215555296173
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/409	32/9376	0.71638141809291	TNFRSF1A	-0.343215555296173
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/409	63/9376	0.727752551713432	POLR2A/DDB1	-0.463034124310122
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/409	120/9376	0.764140179299103	BEX3/MAGED1/MAP2K5/NRAS	-0.555337014832841
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/409	34/9376	0.674241334675679	POLR2A	-0.406386442834998
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/409	65/9376	0.705360165506865	CACNA1C/PBX1	-0.509065522100657
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/409	36/9376	0.636783482749253	GALNT9	-0.466301818793677
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/409	68/9376	0.674241334675679	RUNX1T1/NRAS	-0.575765917658498
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	6/409	180/9376	0.764140179299103	CCL2/TNFRSF1A/ZC3HAV1/IRF9/IFNAR1/PPP1CB	-0.68236138595955
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/409	154/9376	0.744292382434192	AK1/TDO2/NQO1/MAT2A/ALDH2	-0.683305906390532
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/409	37/9376	0.619573118350624	GFPT2	-0.495160028243554
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/409	37/9376	0.619573118350624	MIF	-0.495160028243554
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/409	37/9376	0.619573118350624	GFPT2	-0.495160028243554
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/409	37/9376	0.619573118350624	NRAS	-0.495160028243554
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/409	69/9376	0.664469721129655	NRAS/PRKCA	-0.597413611743227
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/409	70/9376	0.654977296542089	NRAS/ELOB	-0.618783717159734
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/409	38/9376	0.603268562604555	GFPT2	-0.523341514168661
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/409	38/9376	0.603268562604555	PRKCA	-0.523341514168661
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/409	100/9376	0.687726161369193	ITGA2/ITGA3/EPOR	-0.670469365444356
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/409	101/9376	0.680916991454647	WNT2/NRAS/PRKCA	-0.688543072729466
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/409	39/9376	0.587800137922387	MAT2A	-0.550884018713446
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/409	187/9376	0.735536001464378	ANTXR1/CCL2/IRF9/IFNAR1/SUGT1/CASP4	-0.780147901705286
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/409	73/9376	0.628060421341729	MGST1/GSTP1	-0.681311973948939
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/409	133/9376	0.689449785833778	HCST/NRAS/IFNAR1/PRKCA	-0.770326581758864
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	7/409	217/9376	0.739490496095907	EGFR/FGF7/FGF2/CACNA1C/MGST1/NRAS/PRKCA	-0.829188206634935
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/409	75/9376	0.611312143439283	MGST1/GSTP1	-0.721756143762591
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/409	75/9376	0.611312143439283	SERPINE1/IGFBP3	-0.721756143762591
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/409	75/9376	0.611312143439283	GPX8/PRKCA	-0.721756143762591
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/409	136/9376	0.674241334675679	CD46/CSNK2A2/IRF9/IFNAR1	-0.81724665721797
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	4/409	137/9376	0.669319865079507	ACTB/ACTG1/TNFRSF1A/NRAS	-0.83268283755973
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	8/409	250/9376	0.733574572127139	AP1S1/ATP6V0E1/MAN2B1/AP2S1/GGA1/IDS/GAA/VPS26A	-0.911862070579069
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/409	109/9376	0.630941432448801	GFPT2/TNFRSF1A/PPP1CB	-0.8276803915983
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/409	139/9376	0.659689363423687	EGFR/MMP2/KRT19/NRAS	-0.863259087869698
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	6/409	196/9376	0.701761389152238	GNG11/FGF2/TNFRSF1A/NRAS/IRF9/IFNAR1	-0.90114415514818
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/409	46/9376	0.498352290847241	FTH1	-0.728384397964131
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/409	143/9376	0.64123651409715	C1R/C1S/C7/RO60	-0.923269615771553
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/409	82/9376	0.559126960462759	MGST1/GSTP1	-0.856333316313453
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/409	49/9376	0.467840926101492	FOSB	-0.797613012745242
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	6/409	205/9376	0.67095235255531	PKM/HDAC8/NRAS/PSMC1/IRF9/DDB1	-1.01730477093841
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/409	117/9376	0.587800137922387	ACTB/ACTG1/MBD2	-0.958169711341862
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/409	85/9376	0.539393067740544	AK1/ENPP1	-0.911029437072646
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/409	86/9376	0.533121055324956	CACNA1C/SCN9A	-0.928900858999354
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/409	51/9376	0.44949422311712	ENPP2	-0.841872369058366
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/409	87/9376	0.52699322710283	EGFR/NRAS	-0.946599371019519
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/409	52/9376	0.440850103441791	HSD17B2	-0.863480423007551
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/409	52/9376	0.440850103441791	ANGPTL4	-0.863480423007551
Genetic Information Processing	Transcription	hsa03040	Spliceosome	7/409	243/9376	0.66036805618441	DDX39B/BUD31/SF3B2/ACIN1/CCDC12/SF1/ZMAT2	-1.14558850185093
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/409	155/9376	0.591592396876725	EGFR/WNT2/CACNA1C/PBX1	-1.09495019163664
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/409	91/9376	0.503828689647761	CD81/NRAS	-1.01574594750101
NA	NA	hsa04081	Hormone signaling	6/409	219/9376	0.628060421341729	PRKG1/GNG11/BMPR1A/GHR/CSH1/EPOR	-1.18943729679805
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/409	191/9376	0.600110088454793	GNG11/HDAC8/NRAS/FOSB/PPP1CB	-1.19245296692877
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/409	59/9376	0.3885458538809	ENPP1	-1.00617971978633
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/409	59/9376	0.3885458538809	PRKG1	-1.00617971978633
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	4/409	163/9376	0.562557187214064	NRAS/IFNAR1/PRKCA/DDB1	-1.2032012083019
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/409	195/9376	0.587800137922387	ACTB/ACTG1/HDAC8/PRKCA/CASP4	-1.24223528631655
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/409	133/9376	0.517087339375333	EGFR/FBXO32/NRAS	-1.1978753907668
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/409	62/9376	0.369745248047953	NRAS	-1.06332876891455
NA	NA	hsa04082	Neuroactive ligand signaling	5/409	199/9376	0.575985059773194	GNG11/GRIA4/GRIA3/GRIK2/PRKCA	-1.29116290099584
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/409	66/9376	0.347336445135956	RORA	-1.13634497734975
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	5/409	205/9376	0.559126960462759	PSMD11/PSMC1/IRF9/IFNAR1/PSMC4	-1.36303131167271
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/409	68/9376	0.33712066733784	ALDH1A3	-1.1716137370808
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/409	144/9376	0.47758761206194	TNFRSF1A/ALDH2/LPIN2	-1.34918194969088
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/409	109/9376	0.420627621632534	IRF9/IFNAR1	-1.29934703911703
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/409	70/9376	0.327488648271044	TNFRSF1A	-1.20612084330771
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/409	71/9376	0.322876132098213	NRAS	-1.22310239178836
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/409	77/9376	0.297716952973677	EGFR	-1.32148771706142
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/409	77/9376	0.297716952973677	NRAS	-1.32148771706142
Genetic Information Processing	Translation	hsa03010	Ribosome	5/409	222/9376	0.516310931958854	RPL29/RSL24D1/RPS26/MRPL17/RPS14	-1.55761819771693
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/409	78/9376	0.293900068961194	PATL1	-1.33734176207425
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/409	78/9376	0.293900068961194	ITGB1	-1.33734176207425
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	1/409	82/9376	0.279563480231379	PSME1	-1.3993457046372
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/409	83/9376	0.276195245529796	PRDX1	-1.41451063313794
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/409	83/9376	0.276195245529796	IL33	-1.41451063313794
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	3/409	169/9376	0.406938557023191	SQSTM1/NRAS/RRAS	-1.66152805201707
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/409	90/9376	0.254713393099701	NRAS	-1.51723879632043
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/409	370/9376	0.557615806515562	BDKRB1/GRIA4/GRIA3/GRIK2/SPX/EDNRA/GHR/CSH1/BDKRB2	-1.85420692681561
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/409	138/9376	0.332234860564828	CPEB1/PPP1CB	-1.68771074198965
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/409	138/9376	0.332234860564828	NRAS/PPP1CB	-1.68771074198965
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/409	98/9376	0.233920463050746	PRKCA	-1.62810879728997
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/409	183/9376	0.375806645556936	CSNK2A2/REXO1/NOP58	-1.82112502684469
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/409	107/9376	0.214244910083861	PKM	-1.74576731438009
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/409	109/9376	0.210313810816267	RORA	-1.77101368663576
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/409	110/9376	0.208401867081574	CPEB1	-1.7835227900329
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	2/409	158/9376	0.29017981492371	HDAC8/MAU2	-1.92168519413326
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/409	122/9376	0.187903322778468	NRAS	-1.92817571458912
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	6/409	323/9376	0.425836632426745	EGFR/PDGFRA/TPM1/NRAS/EFNA5/PRKCA	-2.24266388167041
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	2/409	181/9376	0.253306136784233	TNFRSF1A/ARHGEF12	-2.16635541990634
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	3/409	224/9376	0.307020607754104	TNFRSF1A/NRAS/FDPS	-2.24186796169987
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/409	449/9376	0.0510561367014991	PRKG1	-4.40083040089107