ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0005201 extracellular matrix structural constituent 46/729 168/18639 0.273809523809524 7.00073486184597 2.30952044437592e-26 2.15016353371398e-23 GO:0005178 integrin binding 28/729 161/18639 0.173913043478261 4.44659151905529 2.81243114476479e-11 1.30918669788801e-08 GO:0005518 collagen binding 17/729 72/18639 0.236111111111111 6.03686556927298 1.76295735603767e-09 5.47104432823691e-07 GO:0019838 growth factor binding 23/729 136/18639 0.169117647058824 4.32398329702251 2.91365731650547e-09 6.78153740416648e-07 GO:0005539 glycosaminoglycan binding 31/729 242/18639 0.128099173553719 3.27522701765126 6.42393561411578e-09 1.19613681134836e-06 GO:1901681 sulfur compound binding 32/729 275/18639 0.116363636363636 2.97517396184063 3.79737358974314e-08 5.20672401831786e-06 GO:0048407 platelet-derived growth factor binding 7/729 11/18639 0.636363636363636 16.2704826038159 3.9148300889608e-08 5.20672401831786e-06 GO:0008201 heparin binding 24/729 172/18639 0.13953488372093 3.56761412575366 6.41816597531843e-08 7.46914065377682e-06 GO:0030020 extracellular matrix structural constituent conferring tensile strength 12/729 44/18639 0.272727272727273 6.97306397306397 7.80565576821412e-08 8.07451724467483e-06 GO:0003779 actin binding 38/729 443/18639 0.0857787810383747 2.19318340161079 5.28948180571612e-06 0.000492450756112171 GO:0098631 cell adhesion mediator activity 13/729 76/18639 0.171052631578947 4.37345679012346 7.07045144909877e-06 0.000598417299919178 GO:0050840 extracellular matrix binding 12/729 67/18639 0.17910447761194 4.57932559425097 9.7262134779665e-06 0.000754592062332235 GO:0001968 fibronectin binding 8/729 30/18639 0.266666666666667 6.81810699588477 1.43469471860037e-05 0.00102746214078227 GO:0005522 profilin binding 5/729 10/18639 0.5 12.783950617284 1.93130194810583e-05 0.00128431579549037 GO:0043236 laminin binding 7/729 29/18639 0.241379310344828 6.17156236696467 9.99344225784894e-05 0.00620259649470491 GO:0045296 cadherin binding 27/729 334/18639 0.0808383233532934 2.06686626746507 0.000312712326049986 0.0181959484720335 GO:0004601 peroxidase activity 9/729 57/18639 0.157894736842105 4.03703703703704 0.000340634162935821 0.0186547297466617 GO:0004222 metalloendopeptidase activity 13/729 110/18639 0.118181818181818 3.02166105499439 0.000363190618930828 0.0187850259013667 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 9/729 59/18639 0.152542372881356 3.90018832391714 0.000443825093155542 0.0217474295646215 GO:0097493 structural molecule activity conferring elasticity 4/729 11/18639 0.363636363636364 9.29741863075196 0.000614544955179041 0.0286070676635844 GO:0005520 insulin-like growth factor binding 5/729 19/18639 0.263157894736842 6.72839506172839 0.000664372481317005 0.0294538466717205 GO:0008307 structural constituent of muscle 7/729 42/18639 0.166666666666667 4.26131687242798 0.00111107548856022 0.0470186945386166 GO:0031994 insulin-like growth factor I binding 4/729 13/18639 0.307692307692308 7.8670465337132 0.00125071745774095 0.0474449301188 GO:0098632 cell-cell adhesion mediator activity 8/729 55/18639 0.145454545454545 3.71896745230079 0.00126091578324615 0.0474449301188 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 9/729 68/18639 0.132352941176471 3.38398692810458 0.00127403142102041 0.0474449301188 GO:0004175 endopeptidase activity 29/729 405/18639 0.0716049382716049 1.83078798963573 0.00134012827534801 0.0479869009364998 GO:0003954 NADH dehydrogenase activity 7/729 44/18639 0.159090909090909 4.06762065095398 0.00147509351329284 0.0492739293032834 GO:0051015 actin filament binding 18/729 209/18639 0.0861244019138756 2.2020202020202 0.00148192268581304 0.0492739293032834 GO:0004602 glutathione peroxidase activity 5/729 23/18639 0.217391304347826 5.55823939881911 0.00168875171184475 0.0542147532319816 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 8/729 58/18639 0.137931034482759 3.52660706683695 0.00179142688194064 0.0555939475695577 GO:0016209 antioxidant activity 10/729 86/18639 0.116279069767442 2.97301177146138 0.0019089968381176 0.0568793964506892 GO:0009055 electron transfer activity 12/729 116/18639 0.103448275862069 2.64495530012771 0.0019550383312804 0.0568793964506892 GO:0017171 serine hydrolase activity 17/729 198/18639 0.0858585858585859 2.19522384337199 0.00204648162249134 0.0577355875921042 GO:0008237 metallopeptidase activity 16/729 184/18639 0.0869565217391304 2.22329575952764 0.00240479394591799 0.065848916577931 GO:0002020 protease binding 13/729 136/18639 0.0955882352941176 2.44399055918664 0.00262970338921544 0.0699501101531308 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 4/729 16/18639 0.25 6.39197530864198 0.0028992683974205 0.0749783021666247 GO:0061134 peptidase regulator activity 18/729 226/18639 0.079646017699115 2.03638151425762 0.00347748427302315 0.0875010231941772 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/729 17/18639 0.235294117647059 6.0159767610748 0.00367525491975132 0.0877349315458584 GO:0019198 transmembrane receptor protein phosphatase activity 4/729 17/18639 0.235294117647059 6.0159767610748 0.00367525491975132 0.0877349315458584 GO:0004252 serine-type endopeptidase activity 15/729 176/18639 0.0852272727272727 2.17908249158249 0.00391420508953851 0.0911031234590088 GO:0008236 serine-type peptidase activity 16/729 194/18639 0.0824742268041237 2.10869288532519 0.00406245057681244 0.0922473533417655 GO:0045499 chemorepellent activity 5/729 28/18639 0.178571428571429 4.56569664902998 0.00419762832697853 0.0927409934996394 GO:0016860 intramolecular oxidoreductase activity 7/729 53/18639 0.132075471698113 3.37689261588633 0.00438303299031593 0.0927409934996394 GO:0038064 collagen receptor activity 7/729 53/18639 0.132075471698113 3.37689261588633 0.00438303299031593 0.0927409934996394 GO:0070064 proline-rich region binding 4/729 18/18639 0.222222222222222 5.68175582990398 0.00458083941824247 0.0947724777418608 GO:0035925 mRNA 3'-UTR AU-rich region binding 5/729 30/18639 0.166666666666667 4.26131687242798 0.00570765094242621 0.115517891899974 GO:0022853 active monoatomic ion transmembrane transporter activity 11/729 118/18639 0.0932203389830508 2.38344842017158 0.00655199073635445 0.129785178203106 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 4/729 20/18639 0.2 5.11358024691358 0.00681715536054302 0.132224409180532 GO:0016651 oxidoreductase activity, acting on NAD(P)H 9/729 88/18639 0.102272727272727 2.61489898989899 0.0074196307996991 0.140972985194283 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/729 11/18639 0.272727272727273 6.97306397306397 0.0077693195593873 0.141828166858619 GO:0050998 nitric-oxide synthase binding 3/729 11/18639 0.272727272727273 6.97306397306397 0.0077693195593873 0.141828166858619 GO:0004879 nuclear receptor activity 7/729 59/18639 0.11864406779661 3.03347980749111 0.00793548274305634 0.142075662188182 GO:0036122 BMP binding 4/729 21/18639 0.19047619047619 4.87007642563198 0.00816481740340884 0.143423490614597 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 11/729 122/18639 0.0901639344262295 2.30530257032989 0.00836011001061016 0.144134489257001 GO:0098531 ligand-modulated transcription factor activity 7/729 60/18639 0.116666666666667 2.98292181069959 0.00868859423863647 0.14707420429401 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/729 22/18639 0.181818181818182 4.64870931537598 0.00967586422665326 0.160861242768111 GO:0004032 aldose reductase (NADPH) activity 3/729 12/18639 0.25 6.39197530864198 0.0100612953478873 0.161501137394536 GO:0031543 peptidyl-proline dioxygenase activity 3/729 12/18639 0.25 6.39197530864198 0.0100612953478873 0.161501137394536 GO:0019199 transmembrane receptor protein kinase activity 8/729 78/18639 0.102564102564103 2.62234884457107 0.0111068276075428 0.174804720952432 GO:0008083 growth factor activity 13/729 162/18639 0.0802469135802469 2.05174516079866 0.0112656103728742 0.174804720952432 GO:0046332 SMAD binding 8/729 79/18639 0.10126582278481 2.58915455539928 0.0119481282857259 0.182355859573948 GO:0005200 structural constituent of cytoskeleton 10/729 112/18639 0.0892857142857143 2.28284832451499 0.0124011696335801 0.18416237177415 GO:0045505 dynein intermediate chain binding 5/729 36/18639 0.138888888888889 3.55109739368999 0.0124621153832132 0.18416237177415 GO:0005006 epidermal growth factor receptor activity 6/729 50/18639 0.12 3.06814814814815 0.0128964245078818 0.186422520080613 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 4/729 24/18639 0.166666666666667 4.26131687242798 0.0132157747855214 0.186422520080613 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 4/729 24/18639 0.166666666666667 4.26131687242798 0.0132157747855214 0.186422520080613 GO:0001618 virus receptor activity 8/729 81/18639 0.0987654320987654 2.52522481329066 0.0137699009280375 0.190765766382959 GO:0043394 proteoglycan binding 5/729 37/18639 0.135135135135135 3.45512178845512 0.0139574420245204 0.190765766382959 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 11/729 132/18639 0.0833333333333333 2.13065843621399 0.014573237960149 0.190765766382959 GO:0035401 histone H3Y41 kinase activity 10/729 115/18639 0.0869565217391304 2.22329575952764 0.0147326221359706 0.190765766382959 GO:0140801 histone H2AXY142 kinase activity 10/729 115/18639 0.0869565217391304 2.22329575952764 0.0147326221359706 0.190765766382959 GO:0140272 exogenous protein binding 8/729 82/18639 0.0975609756097561 2.49442938873833 0.0147530990113567 0.190765766382959 GO:0005080 protein kinase C binding 6/729 52/18639 0.115384615384615 2.95014245014245 0.0154785986600639 0.193382131142712 GO:0030414 peptidase inhibitor activity 13/729 169/18639 0.0769230769230769 1.9667616334283 0.0155990953556337 0.193382131142712 GO:1990825 sequence-specific mRNA binding 3/729 14/18639 0.214285714285714 5.47883597883598 0.0157064622260112 0.193382131142712 GO:0001540 amyloid-beta binding 8/729 83/18639 0.0963855421686747 2.46437602260895 0.0157862964198132 0.193382131142712 GO:0004112 cyclic-nucleotide phosphodiesterase activity 4/729 26/18639 0.153846153846154 3.9335232668566 0.0174861361841657 0.211423282954003 GO:0050661 NADP binding 6/729 54/18639 0.111111111111111 2.84087791495199 0.0183982163711231 0.217978721017657 GO:0004129 cytochrome-c oxidase activity 3/729 15/18639 0.2 5.11358024691358 0.0190722678008097 0.217978721017657 GO:0005523 tropomyosin binding 3/729 15/18639 0.2 5.11358024691358 0.0190722678008097 0.217978721017657 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 5/729 40/18639 0.125 3.19598765432099 0.0191530964174567 0.217978721017657 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 8/729 86/18639 0.0930232558139535 2.37840941716911 0.0191989850950031 0.217978721017657 GO:0008137 NADH dehydrogenase (ubiquinone) activity 5/729 41/18639 0.121951219512195 3.11803673592291 0.0211324076352706 0.2370394157643 GO:0004713 protein tyrosine kinase activity 11/729 140/18639 0.0785714285714286 2.00890652557319 0.0216507457939952 0.239962432550113 GO:0051393 alpha-actinin binding 4/729 28/18639 0.142857142857143 3.65255731922399 0.0225263068646258 0.244034345293427 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/729 16/18639 0.1875 4.79398148148148 0.0228044984323611 0.244034345293427 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 3/729 16/18639 0.1875 4.79398148148148 0.0228044984323611 0.244034345293427 GO:0042056 chemoattractant activity 5/729 42/18639 0.119047619047619 3.04379776601999 0.0232403160081492 0.245871979586215 GO:0004866 endopeptidase inhibitor activity 12/729 161/18639 0.0745341614906832 1.90568207959512 0.0244854344461284 0.256134151340961 GO:0003785 actin monomer binding 4/729 29/18639 0.137931034482759 3.52660706683695 0.0253446551044784 0.262176376691882 GO:0019955 cytokine binding 11/729 144/18639 0.0763888888888889 1.95310356652949 0.026011581118593 0.266118483751759 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/729 17/18639 0.176470588235294 4.5119825708061 0.026903622042206 0.27225295784015 GO:0008106 alcohol dehydrogenase (NADP+) activity 4/729 30/18639 0.133333333333333 3.40905349794239 0.0283657326678711 0.278882453285261 GO:0017022 myosin binding 7/729 76/18639 0.0921052631578947 2.35493827160494 0.0289316528240607 0.278882453285261 GO:0061135 endopeptidase regulator activity 13/729 184/18639 0.0706521739130435 1.80642780461621 0.0290303784194004 0.278882453285261 GO:0001098 basal transcription machinery binding 6/729 60/18639 0.1 2.55679012345679 0.029356047714238 0.278882453285261 GO:0001099 basal RNA polymerase II transcription machinery binding 6/729 60/18639 0.1 2.55679012345679 0.029356047714238 0.278882453285261 GO:0004714 transmembrane receptor protein tyrosine kinase activity 6/729 60/18639 0.1 2.55679012345679 0.029356047714238 0.278882453285261 GO:0015078 proton transmembrane transporter activity 13/729 185/18639 0.0702702702702703 1.79666332999666 0.0301561965781598 0.2835900910532 GO:0004970 glutamate-gated receptor activity 3/729 18/18639 0.166666666666667 4.26131687242798 0.0313681785669987 0.288351762714571 GO:0098641 cadherin binding involved in cell-cell adhesion 3/729 18/18639 0.166666666666667 4.26131687242798 0.0313681785669987 0.288351762714571 GO:0017147 Wnt-protein binding 4/729 31/18639 0.129032258064516 3.29908403026683 0.0315917076228639 0.288351762714571 GO:0004867 serine-type endopeptidase inhibitor activity 8/729 95/18639 0.0842105263157895 2.15308641975309 0.0325401834628154 0.294125347610497 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 5/729 46/18639 0.108695652173913 2.77911969940955 0.0330060971494373 0.295468042751213 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/729 32/18639 0.125 3.19598765432099 0.0350241664226968 0.310547608947912 GO:0005507 copper ion binding 6/729 63/18639 0.0952380952380952 2.43503821281599 0.0361629127573988 0.312014144445525 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/729 19/18639 0.157894736842105 4.03703703703704 0.0361949813105443 0.312014144445525 GO:0030506 ankyrin binding 3/729 19/18639 0.157894736842105 4.03703703703704 0.0361949813105443 0.312014144445525 GO:0004857 enzyme inhibitor activity 24/729 416/18639 0.0576923076923077 1.47507122507123 0.0379209511693426 0.318856884150329 GO:0030296 protein tyrosine kinase activator activity 4/729 33/18639 0.121212121212121 3.09913954358399 0.0386641300705558 0.318856884150329 GO:0038024 cargo receptor activity 6/729 65/18639 0.0923076923076923 2.36011396011396 0.0412194774016707 0.318856884150329 GO:0031418 L-ascorbic acid binding 3/729 20/18639 0.15 3.83518518518519 0.0413793035370151 0.318856884150329 GO:0005004 GPI-linked ephrin receptor activity 5/729 49/18639 0.102040816326531 2.60896951373142 0.0417836088789904 0.318856884150329 GO:0005008 hepatocyte growth factor receptor activity 5/729 49/18639 0.102040816326531 2.60896951373142 0.0417836088789904 0.318856884150329 GO:0005009 insulin receptor activity 5/729 49/18639 0.102040816326531 2.60896951373142 0.0417836088789904 0.318856884150329 GO:0005011 macrophage colony-stimulating factor receptor activity 5/729 49/18639 0.102040816326531 2.60896951373142 0.0417836088789904 0.318856884150329 GO:0005018 platelet-derived growth factor alpha-receptor activity 5/729 49/18639 0.102040816326531 2.60896951373142 0.0417836088789904 0.318856884150329 GO:0005020 stem cell factor receptor activity 5/729 49/18639 0.102040816326531 2.60896951373142 0.0417836088789904 0.318856884150329 GO:0008288 boss receptor activity 5/729 49/18639 0.102040816326531 2.60896951373142 0.0417836088789904 0.318856884150329 GO:0036332 placental growth factor receptor activity 5/729 49/18639 0.102040816326531 2.60896951373142 0.0417836088789904 0.318856884150329 GO:0038062 protein tyrosine kinase collagen receptor activity 5/729 49/18639 0.102040816326531 2.60896951373142 0.0417836088789904 0.318856884150329 GO:0060175 brain-derived neurotrophic factor receptor activity 5/729 49/18639 0.102040816326531 2.60896951373142 0.0417836088789904 0.318856884150329 GO:0005007 fibroblast growth factor receptor activity 5/729 50/18639 0.1 2.55679012345679 0.0449932960313358 0.335110068841389 GO:0005017 platelet-derived growth factor receptor activity 5/729 50/18639 0.1 2.55679012345679 0.0449932960313358 0.335110068841389 GO:0005019 platelet-derived growth factor beta-receptor activity 5/729 50/18639 0.1 2.55679012345679 0.0449932960313358 0.335110068841389 GO:0070851 growth factor receptor binding 10/729 139/18639 0.0719424460431655 1.83941735500488 0.0463988712393883 0.341375985869517 GO:0016229 steroid dehydrogenase activity 4/729 35/18639 0.114285714285714 2.92204585537919 0.0465679379220501 0.341375985869517 GO:0005010 insulin-like growth factor receptor activity 5/729 51/18639 0.0980392156862745 2.50665698378117 0.048346205827022 0.346233212499673 GO:0005021 vascular endothelial growth factor receptor activity 5/729 51/18639 0.0980392156862745 2.50665698378117 0.048346205827022 0.346233212499673 GO:0005030 neurotrophin receptor activity 5/729 51/18639 0.0980392156862745 2.50665698378117 0.048346205827022 0.346233212499673 GO:0030246 carbohydrate binding 17/729 280/18639 0.0607142857142857 1.55233686067019 0.0492542945876036 0.350043879855412 GO:0004033 aldo-keto reductase (NADPH) activity 4/729 36/18639 0.111111111111111 2.84087791495199 0.0508311657394047 0.358513752298377 GO:0008093 cytoskeletal anchor activity 3/729 22/18639 0.136363636363636 3.48653198653199 0.0527949228574173 0.369564460001921 GO:0008081 phosphoric diester hydrolase activity 7/729 87/18639 0.0804597701149425 2.05718745565489 0.0539146604388349 0.371197206849656 GO:0042805 actinin binding 4/729 37/18639 0.108108108108108 2.7640974307641 0.0553007080078755 0.371197206849656 GO:0005003 ephrin receptor activity 5/729 53/18639 0.0943396226415094 2.41206615420452 0.0554831458152253 0.371197206849656 GO:0005005 transmembrane-ephrin receptor activity 5/729 53/18639 0.0943396226415094 2.41206615420452 0.0554831458152253 0.371197206849656 GO:0000182 rDNA binding 2/729 10/18639 0.2 5.11358024691358 0.0558191288495723 0.371197206849656 GO:0001094 TFIID-class transcription factor complex binding 2/729 10/18639 0.2 5.11358024691358 0.0558191288495723 0.371197206849656 GO:0008239 dipeptidyl-peptidase activity 2/729 10/18639 0.2 5.11358024691358 0.0558191288495723 0.371197206849656 GO:0017134 fibroblast growth factor binding 3/729 23/18639 0.130434782608696 3.33494363929147 0.0590105570463011 0.383179701744198 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 3/729 23/18639 0.130434782608696 3.33494363929147 0.0590105570463011 0.383179701744198 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 5/729 54/18639 0.0925925925925926 2.36739826245999 0.0592673222891133 0.383179701744198 GO:0051287 NAD binding 5/729 54/18639 0.0925925925925926 2.36739826245999 0.0592673222891133 0.383179701744198 GO:0005109 frizzled binding 4/729 38/18639 0.105263157894737 2.69135802469136 0.0599750540047287 0.385081208816568 GO:0015399 primary active transmembrane transporter activity 11/729 166/18639 0.0662650602409639 1.69425851554366 0.0616987996164286 0.393435496184212 GO:0140313 molecular sequestering activity 5/729 55/18639 0.0909090909090909 2.32435465768799 0.063195022589362 0.39941019751175 GO:0005540 hyaluronic acid binding 3/729 24/18639 0.125 3.19598765432099 0.065552668797841 0.39941019751175 GO:0035035 histone acetyltransferase binding 3/729 24/18639 0.125 3.19598765432099 0.065552668797841 0.39941019751175 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 3/729 24/18639 0.125 3.19598765432099 0.065552668797841 0.39941019751175 GO:0005114 type II transforming growth factor beta receptor binding 2/729 11/18639 0.181818181818182 4.64870931537598 0.0664968642473912 0.39941019751175 GO:0008046 axon guidance receptor activity 2/729 11/18639 0.181818181818182 4.64870931537598 0.0664968642473912 0.39941019751175 GO:0008432 JUN kinase binding 2/729 11/18639 0.181818181818182 4.64870931537598 0.0664968642473912 0.39941019751175 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/729 11/18639 0.181818181818182 4.64870931537598 0.0664968642473912 0.39941019751175 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/729 11/18639 0.181818181818182 4.64870931537598 0.0664968642473912 0.39941019751175 GO:1902936 phosphatidylinositol bisphosphate binding 8/729 111/18639 0.0720720720720721 1.8427316205094 0.0695301744890871 0.414680071601372 GO:0004177 aminopeptidase activity 4/729 40/18639 0.1 2.55679012345679 0.0699299368865901 0.414680071601372 GO:0016504 peptidase activator activity 5/729 57/18639 0.087719298245614 2.24279835390946 0.0714788344203297 0.421182245856499 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 3/729 25/18639 0.12 3.06814814814815 0.072411175112297 0.423992478173261 GO:0019003 GDP binding 6/729 75/18639 0.08 2.04543209876543 0.0729679411363573 0.424582207487179 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/729 41/18639 0.0975609756097561 2.49442938873833 0.0752053454543004 0.434883084583563 GO:0005125 cytokine activity 14/729 234/18639 0.0598290598290598 1.52970349266646 0.0763629454173885 0.438851248046844 GO:0005165 neurotrophin receptor binding 2/729 12/18639 0.166666666666667 4.26131687242798 0.0777839780272919 0.438890203293387 GO:0045295 gamma-catenin binding 2/729 12/18639 0.166666666666667 4.26131687242798 0.0777839780272919 0.438890203293387 GO:1990459 transferrin receptor binding 2/729 12/18639 0.166666666666667 4.26131687242798 0.0777839780272919 0.438890203293387 GO:0008066 glutamate receptor activity 3/729 26/18639 0.115384615384615 2.95014245014245 0.079575310624662 0.44362044426084 GO:0070006 metalloaminopeptidase activity 3/729 26/18639 0.115384615384615 2.95014245014245 0.079575310624662 0.44362044426084 GO:0048156 tau protein binding 4/729 43/18639 0.0930232558139535 2.37840941716911 0.0863364706353864 0.461556493878816 GO:0004364 glutathione transferase activity 3/729 27/18639 0.111111111111111 2.84087791495199 0.087033733925696 0.461556493878816 GO:0005044 scavenger receptor activity 3/729 27/18639 0.111111111111111 2.84087791495199 0.087033733925696 0.461556493878816 GO:0005104 fibroblast growth factor receptor binding 3/729 27/18639 0.111111111111111 2.84087791495199 0.087033733925696 0.461556493878816 GO:0005172 vascular endothelial growth factor receptor binding 2/729 13/18639 0.153846153846154 3.9335232668566 0.0896166160840848 0.461556493878816 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/729 13/18639 0.153846153846154 3.9335232668566 0.0896166160840848 0.461556493878816 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/729 13/18639 0.153846153846154 3.9335232668566 0.0896166160840848 0.461556493878816 GO:0070123 transforming growth factor beta receptor activity, type III 2/729 13/18639 0.153846153846154 3.9335232668566 0.0896166160840848 0.461556493878816 GO:0070700 BMP receptor binding 2/729 13/18639 0.153846153846154 3.9335232668566 0.0896166160840848 0.461556493878816 GO:0071837 HMG box domain binding 2/729 13/18639 0.153846153846154 3.9335232668566 0.0896166160840848 0.461556493878816 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/729 13/18639 0.153846153846154 3.9335232668566 0.0896166160840848 0.461556493878816 GO:0097157 pre-mRNA intronic binding 2/729 13/18639 0.153846153846154 3.9335232668566 0.0896166160840848 0.461556493878816 GO:0015026 coreceptor activity 5/729 61/18639 0.0819672131147541 2.09572960939081 0.0897333248035076 0.461556493878816 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 5/729 61/18639 0.0819672131147541 2.09572960939081 0.0897333248035076 0.461556493878816 GO:0048306 calcium-dependent protein binding 6/729 80/18639 0.075 1.91759259259259 0.0929191010104523 0.475316939784237 GO:0051959 dynein light intermediate chain binding 3/729 28/18639 0.107142857142857 2.73941798941799 0.0947746251730243 0.482159431891178 GO:0005161 platelet-derived growth factor receptor binding 2/729 14/18639 0.142857142857143 3.65255731922399 0.10193497506043 0.502124136408787 GO:0008191 metalloendopeptidase inhibitor activity 2/729 14/18639 0.142857142857143 3.65255731922399 0.10193497506043 0.502124136408787 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/729 14/18639 0.142857142857143 3.65255731922399 0.10193497506043 0.502124136408787 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 2/729 14/18639 0.142857142857143 3.65255731922399 0.10193497506043 0.502124136408787 GO:0070742 C2H2 zinc finger domain binding 2/729 14/18639 0.142857142857143 3.65255731922399 0.10193497506043 0.502124136408787 GO:0071933 Arp2/3 complex binding 2/729 14/18639 0.142857142857143 3.65255731922399 0.10193497506043 0.502124136408787 GO:0099604 ligand-gated calcium channel activity 3/729 29/18639 0.103448275862069 2.64495530012771 0.102785775565549 0.50365030027119 GO:0033218 amide binding 14/729 247/18639 0.0566801619433198 1.44919278252612 0.10624386425831 0.517869306934484 GO:0160215 deacylase activity 5/729 65/18639 0.0769230769230769 1.9667616334283 0.110157770453561 0.525960350160592 GO:0016769 transferase activity, transferring nitrogenous groups 3/729 30/18639 0.1 2.55679012345679 0.111054669220846 0.525960350160592 GO:0033612 receptor serine/threonine kinase binding 3/729 30/18639 0.1 2.55679012345679 0.111054669220846 0.525960350160592 GO:0098918 structural constituent of synapse 3/729 30/18639 0.1 2.55679012345679 0.111054669220846 0.525960350160592 GO:0005516 calmodulin binding 12/729 207/18639 0.0579710144927536 1.48219717301843 0.113418152028027 0.525960350160592 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/729 15/18639 0.133333333333333 3.40905349794239 0.114683083869603 0.525960350160592 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/729 15/18639 0.133333333333333 3.40905349794239 0.114683083869603 0.525960350160592 GO:0005041 low-density lipoprotein particle receptor activity 2/729 15/18639 0.133333333333333 3.40905349794239 0.114683083869603 0.525960350160592 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 2/729 15/18639 0.133333333333333 3.40905349794239 0.114683083869603 0.525960350160592 GO:0030553 cGMP binding 2/729 15/18639 0.133333333333333 3.40905349794239 0.114683083869603 0.525960350160592 GO:0031005 filamin binding 2/729 15/18639 0.133333333333333 3.40905349794239 0.114683083869603 0.525960350160592 GO:0051371 muscle alpha-actinin binding 2/729 15/18639 0.133333333333333 3.40905349794239 0.114683083869603 0.525960350160592 GO:0016500 protein-hormone receptor activity 5/729 67/18639 0.0746268656716418 1.9080523309379 0.121143619488948 0.552477171576603 GO:0008013 beta-catenin binding 7/729 106/18639 0.0660377358490566 1.68844630794316 0.12165179395618 0.552477171576603 GO:0043177 organic acid binding 11/729 189/18639 0.0582010582010582 1.48807890783199 0.12323132939004 0.556933823602561 GO:0001222 transcription corepressor binding 4/729 49/18639 0.0816326530612245 2.08717561098513 0.124084414619819 0.558080144980926 GO:0032934 sterol binding 5/729 68/18639 0.0735294117647059 1.87999273783588 0.126821453432308 0.558228163395041 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/729 16/18639 0.125 3.19598765432099 0.127808596074923 0.558228163395041 GO:0005024 transforming growth factor beta receptor activity 2/729 16/18639 0.125 3.19598765432099 0.127808596074923 0.558228163395041 GO:0008142 oxysterol binding 2/729 16/18639 0.125 3.19598765432099 0.127808596074923 0.558228163395041 GO:0015562 efflux transmembrane transporter activity 2/729 16/18639 0.125 3.19598765432099 0.127808596074923 0.558228163395041 GO:0016722 oxidoreductase activity, acting on metal ions 2/729 16/18639 0.125 3.19598765432099 0.127808596074923 0.558228163395041 GO:0043425 bHLH transcription factor binding 3/729 32/18639 0.09375 2.39699074074074 0.12831452950219 0.558228163395041 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 3/729 33/18639 0.0909090909090909 2.32435465768799 0.137279569445353 0.589755487544161 GO:0140311 protein sequestering activity 3/729 33/18639 0.0909090909090909 2.32435465768799 0.137279569445353 0.589755487544161 GO:0097110 scaffold protein binding 5/729 70/18639 0.0714285714285714 1.82627865961199 0.138533304011159 0.589755487544161 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/729 17/18639 0.117647058823529 3.0079883805374 0.141262592612619 0.589755487544161 GO:0008484 sulfuric ester hydrolase activity 2/729 17/18639 0.117647058823529 3.0079883805374 0.141262592612619 0.589755487544161 GO:0008569 minus-end-directed microtubule motor activity 2/729 17/18639 0.117647058823529 3.0079883805374 0.141262592612619 0.589755487544161 GO:0051787 misfolded protein binding 2/729 17/18639 0.117647058823529 3.0079883805374 0.141262592612619 0.589755487544161 GO:0070403 NAD+ binding 2/729 17/18639 0.117647058823529 3.0079883805374 0.141262592612619 0.589755487544161 GO:0070492 oligosaccharide binding 2/729 17/18639 0.117647058823529 3.0079883805374 0.141262592612619 0.589755487544161 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 4/729 52/18639 0.0769230769230769 1.9667616334283 0.145172215255444 0.603372019655441 GO:0015035 protein-disulfide reductase activity 3/729 34/18639 0.0882352941176471 2.25599128540305 0.146450617577701 0.605980110954842 GO:0035091 phosphatidylinositol binding 15/729 284/18639 0.0528169014084507 1.35041731872718 0.147870836654181 0.609149331526738 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/729 18/18639 0.111111111111111 2.84087791495199 0.154999394368321 0.622001879986668 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/729 18/18639 0.111111111111111 2.84087791495199 0.154999394368321 0.622001879986668 GO:0017075 syntaxin-1 binding 2/729 18/18639 0.111111111111111 2.84087791495199 0.154999394368321 0.622001879986668 GO:0030228 lipoprotein particle receptor activity 2/729 18/18639 0.111111111111111 2.84087791495199 0.154999394368321 0.622001879986668 GO:0031690 adrenergic receptor binding 2/729 18/18639 0.111111111111111 2.84087791495199 0.154999394368321 0.622001879986668 GO:0035615 clathrin adaptor activity 2/729 18/18639 0.111111111111111 2.84087791495199 0.154999394368321 0.622001879986668 GO:0005154 epidermal growth factor receptor binding 3/729 35/18639 0.0857142857142857 2.19153439153439 0.155814618795418 0.622589742912164 GO:0051213 dioxygenase activity 6/729 93/18639 0.0645161290322581 1.64954201513341 0.156728121850914 0.623563595911115 GO:0003925 G protein activity 4/729 54/18639 0.0740740740740741 1.89391860996799 0.159951887916868 0.633681734683422 GO:0017124 SH3 domain binding 7/729 115/18639 0.0608695652173913 1.55630703166935 0.164175478203089 0.647395117836116 GO:0000993 RNA polymerase II complex binding 3/729 36/18639 0.0833333333333333 2.13065843621399 0.165358569073237 0.647395117836116 GO:0016922 nuclear receptor binding 8/729 137/18639 0.0583941605839416 1.49301613048572 0.168704221193505 0.647395117836116 GO:0003756 protein disulfide isomerase activity 2/729 19/18639 0.105263157894737 2.69135802469136 0.168976384139824 0.647395117836116 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 2/729 19/18639 0.105263157894737 2.69135802469136 0.168976384139824 0.647395117836116 GO:0042800 histone H3K4 methyltransferase activity 2/729 19/18639 0.105263157894737 2.69135802469136 0.168976384139824 0.647395117836116 GO:0043395 heparan sulfate proteoglycan binding 2/729 19/18639 0.105263157894737 2.69135802469136 0.168976384139824 0.647395117836116 GO:0070003 threonine-type peptidase activity 2/729 19/18639 0.105263157894737 2.69135802469136 0.168976384139824 0.647395117836116 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 10/729 181/18639 0.0552486187845304 1.41259122842917 0.17261489857811 0.658624879410739 GO:0019213 deacetylase activity 3/729 37/18639 0.0810810810810811 2.07307307307307 0.175069556814299 0.660573205047102 GO:0030551 cyclic nucleotide binding 3/729 37/18639 0.0810810810810811 2.07307307307307 0.175069556814299 0.660573205047102 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 4/729 56/18639 0.0714285714285714 1.82627865961199 0.175254115624741 0.660573205047102 GO:0042277 peptide binding 13/729 249/18639 0.0522088353413655 1.33487034557985 0.178879618477825 0.671519858076028 GO:0000339 RNA cap binding 2/729 20/18639 0.1 2.55679012345679 0.183153837540136 0.679347500995485 GO:0005326 neurotransmitter transmembrane transporter activity 2/729 20/18639 0.1 2.55679012345679 0.183153837540136 0.679347500995485 GO:0140939 histone H4 methyltransferase activity 2/729 20/18639 0.1 2.55679012345679 0.183153837540136 0.679347500995485 GO:0004725 protein tyrosine phosphatase activity 6/729 98/18639 0.0612244897959184 1.56538170823885 0.185328866632347 0.68468720172506 GO:0005126 cytokine receptor binding 14/729 275/18639 0.0509090909090909 1.30163860830527 0.191101783828102 0.702065606273305 GO:0020037 heme binding 8/729 142/18639 0.0563380281690141 1.44044513997566 0.19283225259694 0.702065606273305 GO:0005123 death receptor binding 2/729 21/18639 0.0952380952380952 2.43503821281599 0.197494762415314 0.702065606273305 GO:0005248 voltage-gated sodium channel activity 2/729 21/18639 0.0952380952380952 2.43503821281599 0.197494762415314 0.702065606273305 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/729 21/18639 0.0952380952380952 2.43503821281599 0.197494762415314 0.702065606273305 GO:0035613 RNA stem-loop binding 2/729 21/18639 0.0952380952380952 2.43503821281599 0.197494762415314 0.702065606273305 GO:0072542 protein phosphatase activator activity 2/729 21/18639 0.0952380952380952 2.43503821281599 0.197494762415314 0.702065606273305 GO:0140312 cargo adaptor activity 2/729 21/18639 0.0952380952380952 2.43503821281599 0.197494762415314 0.702065606273305 GO:0031406 carboxylic acid binding 10/729 187/18639 0.053475935828877 1.36726744569882 0.197993803848219 0.702065606273305 GO:0031593 polyubiquitin modification-dependent protein binding 4/729 59/18639 0.0677966101694915 1.73341703285206 0.199081976429809 0.702065606273305 GO:0070063 RNA polymerase binding 4/729 59/18639 0.0677966101694915 1.73341703285206 0.199081976429809 0.702065606273305 GO:0070888 E-box binding 4/729 59/18639 0.0677966101694915 1.73341703285206 0.199081976429809 0.702065606273305 GO:0015036 disulfide oxidoreductase activity 3/729 40/18639 0.075 1.91759259259259 0.205077766019982 0.715083895747577 GO:0061791 GTPase motor activity 3/729 40/18639 0.075 1.91759259259259 0.205077766019982 0.715083895747577 GO:1990606 membrane scission GTPase motor activity 3/729 40/18639 0.075 1.91759259259259 0.205077766019982 0.715083895747577 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 4/729 60/18639 0.0666666666666667 1.70452674897119 0.207233404617174 0.719904103352944 GO:0008238 exopeptidase activity 6/729 102/18639 0.0588235294117647 1.5039941902687 0.209562859515629 0.725290045386805 GO:0016247 channel regulator activity 9/729 168/18639 0.0535714285714286 1.36970899470899 0.212599999614626 0.73307629496747 GO:0042169 SH2 domain binding 3/729 41/18639 0.0731707317073171 1.87082204155375 0.215330851854114 0.739752852679633 GO:0015085 calcium ion transmembrane transporter activity 8/729 147/18639 0.054421768707483 1.39145040732342 0.218298453716683 0.74719066327291 GO:0141108 transporter regulator activity 9/729 170/18639 0.0529411764705882 1.35359477124183 0.222276073623725 0.758018404921936 GO:0043175 RNA polymerase core enzyme binding 3/729 42/18639 0.0714285714285714 1.82627865961199 0.225688967492593 0.761375873615992 GO:0051879 Hsp90 protein binding 3/729 42/18639 0.0714285714285714 1.82627865961199 0.225688967492593 0.761375873615992 GO:0005158 insulin receptor binding 2/729 23/18639 0.0869565217391304 2.22329575952764 0.226531812021085 0.761375873615992 GO:0099186 structural constituent of postsynapse 2/729 23/18639 0.0869565217391304 2.22329575952764 0.226531812021085 0.761375873615992 GO:0051117 ATPase binding 5/729 84/18639 0.0595238095238095 1.52189888300999 0.231790374081327 0.776247619675234 GO:0005245 voltage-gated calcium channel activity 3/729 43/18639 0.0697674418604651 1.78380706287683 0.236140404756883 0.787981063902001 GO:0001091 RNA polymerase II general transcription initiation factor binding 2/729 24/18639 0.0833333333333333 2.13065843621399 0.241166279586834 0.7905838249836 GO:0030215 semaphorin receptor binding 2/729 24/18639 0.0833333333333333 2.13065843621399 0.241166279586834 0.7905838249836 GO:0030552 cAMP binding 2/729 24/18639 0.0833333333333333 2.13065843621399 0.241166279586834 0.7905838249836 GO:0048027 mRNA 5'-UTR binding 2/729 24/18639 0.0833333333333333 2.13065843621399 0.241166279586834 0.7905838249836 GO:0050699 WW domain binding 2/729 24/18639 0.0833333333333333 2.13065843621399 0.241166279586834 0.7905838249836 GO:0046906 tetrapyrrole binding 8/729 152/18639 0.0526315789473684 1.34567901234568 0.244939896407467 0.797711642515474 GO:0030547 signaling receptor inhibitor activity 3/729 44/18639 0.0681818181818182 1.74326599326599 0.246673733335615 0.797711642515474 GO:0043014 alpha-tubulin binding 3/729 44/18639 0.0681818181818182 1.74326599326599 0.246673733335615 0.797711642515474 GO:0004721 phosphoprotein phosphatase activity 9/729 175/18639 0.0514285714285714 1.31492063492063 0.24716747515475 0.797711642515474 GO:0005496 steroid binding 6/729 108/18639 0.0555555555555556 1.42043895747599 0.247809886850302 0.797711642515474 GO:0003774 cytoskeletal motor activity 8/729 153/18639 0.0522875816993464 1.33688372468329 0.25039395870496 0.797711642515474 GO:0005262 calcium channel activity 7/729 131/18639 0.0534351145038168 1.36622373009141 0.252951935929973 0.797711642515474 GO:0001848 complement binding 2/729 25/18639 0.08 2.04543209876543 0.255840636497664 0.797711642515474 GO:0003707 nuclear steroid receptor activity 2/729 25/18639 0.08 2.04543209876543 0.255840636497664 0.797711642515474 GO:0008483 transaminase activity 2/729 25/18639 0.08 2.04543209876543 0.255840636497664 0.797711642515474 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/729 25/18639 0.08 2.04543209876543 0.255840636497664 0.797711642515474 GO:0017056 structural constituent of nuclear pore 2/729 25/18639 0.08 2.04543209876543 0.255840636497664 0.797711642515474 GO:0019211 phosphatase activator activity 2/729 25/18639 0.08 2.04543209876543 0.255840636497664 0.797711642515474 GO:0047617 fatty acyl-CoA hydrolase activity 2/729 25/18639 0.08 2.04543209876543 0.255840636497664 0.797711642515474 GO:0042578 phosphoric ester hydrolase activity 17/729 363/18639 0.046831955922865 1.19739482365745 0.256535298587523 0.797711642515474 GO:0004715 non-membrane spanning protein tyrosine kinase activity 3/729 45/18639 0.0666666666666667 1.70452674897119 0.257277815498545 0.797711642515474 GO:0008235 metalloexopeptidase activity 4/729 66/18639 0.0606060606060606 1.54956977179199 0.257906771640341 0.797711642515474 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 5/729 89/18639 0.0561797752808989 1.43639894576224 0.268705310500751 0.809848501966684 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 5/729 89/18639 0.0561797752808989 1.43639894576224 0.268705310500751 0.809848501966684 GO:0004435 phosphatidylinositol phospholipase C activity 2/729 26/18639 0.0769230769230769 1.9667616334283 0.270529413653747 0.809848501966684 GO:0005160 transforming growth factor beta receptor binding 2/729 26/18639 0.0769230769230769 1.9667616334283 0.270529413653747 0.809848501966684 GO:0016289 acyl-CoA hydrolase activity 2/729 26/18639 0.0769230769230769 1.9667616334283 0.270529413653747 0.809848501966684 GO:0030247 polysaccharide binding 2/729 26/18639 0.0769230769230769 1.9667616334283 0.270529413653747 0.809848501966684 GO:0030507 spectrin binding 2/729 26/18639 0.0769230769230769 1.9667616334283 0.270529413653747 0.809848501966684 GO:0034237 protein kinase A regulatory subunit binding 2/729 26/18639 0.0769230769230769 1.9667616334283 0.270529413653747 0.809848501966684 GO:0050681 nuclear androgen receptor binding 2/729 26/18639 0.0769230769230769 1.9667616334283 0.270529413653747 0.809848501966684 GO:0050750 low-density lipoprotein particle receptor binding 2/729 26/18639 0.0769230769230769 1.9667616334283 0.270529413653747 0.809848501966684 GO:0016853 isomerase activity 9/729 180/18639 0.05 1.2783950617284 0.272947979890364 0.813865881795574 GO:0001664 G protein-coupled receptor binding 14/729 297/18639 0.0471380471380471 1.205220933616 0.274642501269306 0.813865881795574 GO:0140297 DNA-binding transcription factor binding 22/729 488/18639 0.0450819672131148 1.15265128516495 0.276157904939624 0.813865881795574 GO:0019210 kinase inhibitor activity 5/729 90/18639 0.0555555555555556 1.42043895747599 0.276242340115361 0.813865881795574 GO:0140793 histone H2AXY142 phosphatase activity 5/729 90/18639 0.0555555555555556 1.42043895747599 0.276242340115361 0.813865881795574 GO:0140789 histone phosphatase activity 7/729 136/18639 0.0514705882352941 1.31599491648511 0.283266330390529 0.824626218440322 GO:0098960 postsynaptic neurotransmitter receptor activity 4/729 69/18639 0.0579710144927536 1.48219717301843 0.284107642031068 0.824626218440322 GO:0005385 zinc ion transmembrane transporter activity 2/729 27/18639 0.0740740740740741 1.89391860996799 0.285209068031991 0.824626218440322 GO:0008266 poly(U) RNA binding 2/729 27/18639 0.0740740740740741 1.89391860996799 0.285209068031991 0.824626218440322 GO:0023026 MHC class II protein complex binding 2/729 27/18639 0.0740740740740741 1.89391860996799 0.285209068031991 0.824626218440322 GO:0035255 ionotropic glutamate receptor binding 2/729 27/18639 0.0740740740740741 1.89391860996799 0.285209068031991 0.824626218440322 GO:0140693 molecular condensate scaffold activity 3/729 48/18639 0.0625 1.59799382716049 0.289407841230255 0.832066988415932 GO:0099106 ion channel regulator activity 8/729 160/18639 0.05 1.2783950617284 0.289570036784921 0.832066988415932 GO:0001221 transcription coregulator binding 6/729 115/18639 0.0521739130434783 1.33397745571659 0.294653677129742 0.832472752515801 GO:1901981 phosphatidylinositol phosphate binding 9/729 185/18639 0.0486486486486487 1.24384384384384 0.299470992423655 0.832472752515801 GO:0046875 ephrin receptor binding 2/729 28/18639 0.0714285714285714 1.82627865961199 0.299857871328835 0.832472752515801 GO:0050698 proteoglycan sulfotransferase activity 2/729 28/18639 0.0714285714285714 1.82627865961199 0.299857871328835 0.832472752515801 GO:0051537 2 iron, 2 sulfur cluster binding 2/729 28/18639 0.0714285714285714 1.82627865961199 0.299857871328835 0.832472752515801 GO:0042562 hormone binding 5/729 94/18639 0.0531914893617021 1.35999474651957 0.3067808437102 0.832472752515801 GO:0004181 metallocarboxypeptidase activity 2/729 29/18639 0.0689655172413793 1.76330353341848 0.314455804348337 0.832472752515801 GO:0004629 phospholipase C activity 2/729 29/18639 0.0689655172413793 1.76330353341848 0.314455804348337 0.832472752515801 GO:0003743 translation initiation factor activity 3/729 51/18639 0.0588235294117647 1.5039941902687 0.321803994624521 0.832472752515801 GO:0005272 sodium channel activity 3/729 51/18639 0.0588235294117647 1.5039941902687 0.321803994624521 0.832472752515801 GO:0030544 Hsp70 protein binding 3/729 51/18639 0.0588235294117647 1.5039941902687 0.321803994624521 0.832472752515801 GO:0048029 monosaccharide binding 4/729 74/18639 0.0540540540540541 1.38204871538205 0.328518282465364 0.832472752515801 GO:0008187 poly-pyrimidine tract binding 2/729 30/18639 0.0666666666666667 1.70452674897119 0.328984456857443 0.832472752515801 GO:0048019 receptor antagonist activity 2/729 30/18639 0.0666666666666667 1.70452674897119 0.328984456857443 0.832472752515801 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0004090 carbonyl reductase (NADPH) activity 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0005031 tumor necrosis factor receptor activity 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0005131 growth hormone receptor binding 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0005381 iron ion transmembrane transporter activity 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0005528 FK506 binding 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0008190 eukaryotic initiation factor 4E binding 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0008519 ammonium channel activity 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0015203 polyamine transmembrane transporter activity 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0030957 Tat protein binding 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0031720 haptoglobin binding 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0032052 bile acid binding 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0035374 chondroitin sulfate binding 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0043121 neurotrophin binding 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0043295 glutathione binding 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0047429 nucleoside triphosphate diphosphatase activity 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0050815 phosphoserine residue binding 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0099122 RNA polymerase II C-terminal domain binding 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0140135 mechanosensitive monoatomic cation channel activity 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0140999 histone H3K4 trimethyltransferase activity 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0141109 transporter activator activity 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/729 10/18639 0.1 2.55679012345679 0.329054750725902 0.832472752515801 GO:0005246 calcium channel regulator activity 3/729 53/18639 0.0566037735849057 1.44723969252271 0.34342564999336 0.837453448498643 GO:0140296 general transcription initiation factor binding 3/729 53/18639 0.0566037735849057 1.44723969252271 0.34342564999336 0.837453448498643 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 3/729 53/18639 0.0566037735849057 1.44723969252271 0.34342564999336 0.837453448498643 GO:0008327 methyl-CpG binding 2/729 31/18639 0.0645161290322581 1.64954201513341 0.343426932643234 0.837453448498643 GO:0070325 lipoprotein particle receptor binding 2/729 31/18639 0.0645161290322581 1.64954201513341 0.343426932643234 0.837453448498643 GO:0072349 modified amino acid transmembrane transporter activity 2/729 31/18639 0.0645161290322581 1.64954201513341 0.343426932643234 0.837453448498643 GO:0043130 ubiquitin binding 5/729 100/18639 0.05 1.2783950617284 0.353366356752103 0.837453448498643 GO:0015485 cholesterol binding 3/729 54/18639 0.0555555555555556 1.42043895747599 0.354218224233154 0.837453448498643 GO:0017069 snRNA binding 3/729 54/18639 0.0555555555555556 1.42043895747599 0.354218224233154 0.837453448498643 GO:0140463 chromatin-protein adaptor activity 3/729 54/18639 0.0555555555555556 1.42043895747599 0.354218224233154 0.837453448498643 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:0008199 ferric iron binding 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:0015217 ADP transmembrane transporter activity 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:0019107 myristoyltransferase activity 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:0032050 clathrin heavy chain binding 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:0035252 UDP-xylosyltransferase activity 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:0042285 xylosyltransferase activity 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:0045294 alpha-catenin binding 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:0048185 activin binding 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:0050786 RAGE receptor binding 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:0070697 activin receptor binding 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:0140031 phosphorylation-dependent protein binding 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:1900750 oligopeptide binding 1/729 11/18639 0.0909090909090909 2.32435465768799 0.355310539373753 0.837453448498643 GO:0031369 translation initiation factor binding 2/729 32/18639 0.0625 1.59799382716049 0.357767759519304 0.838996937311012 GO:0070717 poly-purine tract binding 2/729 32/18639 0.0625 1.59799382716049 0.357767759519304 0.838996937311012 GO:0005096 GTPase activator activity 12/729 271/18639 0.044280442804428 1.13215798824655 0.371642596813347 0.847566868712519 GO:0019956 chemokine binding 2/729 33/18639 0.0606060606060606 1.54956977179199 0.371992804040204 0.847566868712519 GO:0033293 monocarboxylic acid binding 4/729 79/18639 0.0506329113924051 1.29457727769964 0.373281151135978 0.847566868712519 GO:0004300 enoyl-CoA hydratase activity 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0005025 transforming growth factor beta receptor activity, type I 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0005026 transforming growth factor beta receptor activity, type II 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0005095 GTPase inhibitor activity 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0005527 macrolide binding 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0008179 adenylate cyclase binding 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0008504 monoamine transmembrane transporter activity 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0016361 activin receptor activity, type I 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0016362 activin receptor activity, type II 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0016801 hydrolase activity, acting on ether bonds 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0016803 ether hydrolase activity 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0017002 activin receptor activity 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0035197 siRNA binding 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0035259 nuclear glucocorticoid receptor binding 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0035497 cAMP response element binding 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/729 12/18639 0.0833333333333333 2.13065843621399 0.380540226768886 0.847566868712519 GO:0008376 acetylgalactosaminyltransferase activity 2/729 34/18639 0.0588235294117647 1.5039941902687 0.38608919069411 0.853798186546832 GO:0015020 glucuronosyltransferase activity 2/729 34/18639 0.0588235294117647 1.5039941902687 0.38608919069411 0.853798186546832 GO:0019825 oxygen binding 2/729 34/18639 0.0588235294117647 1.5039941902687 0.38608919069411 0.853798186546832 GO:0061980 regulatory RNA binding 3/729 58/18639 0.0517241379310345 1.32247765006386 0.39708818645897 0.856548509434499 GO:0005035 death receptor activity 1/729 13/18639 0.0769230769230769 1.9667616334283 0.404783860992619 0.856548509434499 GO:0008035 high-density lipoprotein particle binding 1/729 13/18639 0.0769230769230769 1.9667616334283 0.404783860992619 0.856548509434499 GO:0008417 fucosyltransferase activity 1/729 13/18639 0.0769230769230769 1.9667616334283 0.404783860992619 0.856548509434499 GO:0017154 semaphorin receptor activity 1/729 13/18639 0.0769230769230769 1.9667616334283 0.404783860992619 0.856548509434499 GO:0030955 potassium ion binding 1/729 13/18639 0.0769230769230769 1.9667616334283 0.404783860992619 0.856548509434499 GO:0035673 oligopeptide transmembrane transporter activity 1/729 13/18639 0.0769230769230769 1.9667616334283 0.404783860992619 0.856548509434499 GO:0039706 co-receptor binding 1/729 13/18639 0.0769230769230769 1.9667616334283 0.404783860992619 0.856548509434499 GO:0045159 myosin II binding 1/729 13/18639 0.0769230769230769 1.9667616334283 0.404783860992619 0.856548509434499 GO:0046975 histone H3K36 methyltransferase activity 1/729 13/18639 0.0769230769230769 1.9667616334283 0.404783860992619 0.856548509434499 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/729 13/18639 0.0769230769230769 1.9667616334283 0.404783860992619 0.856548509434499 GO:0031072 heat shock protein binding 6/729 131/18639 0.0458015267175573 1.17104891150693 0.406184630352068 0.856548509434499 GO:0015459 potassium channel regulator activity 3/729 59/18639 0.0508474576271186 1.30006277463905 0.407695661996246 0.856548509434499 GO:0036002 pre-mRNA binding 3/729 59/18639 0.0508474576271186 1.30006277463905 0.407695661996246 0.856548509434499 GO:0045309 protein phosphorylated amino acid binding 3/729 59/18639 0.0508474576271186 1.30006277463905 0.407695661996246 0.856548509434499 GO:0008135 translation factor activity, RNA binding 4/729 83/18639 0.0481927710843374 1.23218801130448 0.408940021951745 0.856548509434499 GO:0005179 hormone activity 6/729 132/18639 0.0454545454545455 1.162177328844 0.413196381950596 0.856548509434499 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 2/729 36/18639 0.0555555555555556 1.42043895747599 0.413850322782955 0.856548509434499 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 2/729 36/18639 0.0555555555555556 1.42043895747599 0.413850322782955 0.856548509434499 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 2/729 36/18639 0.0555555555555556 1.42043895747599 0.413850322782955 0.856548509434499 GO:0004527 exonuclease activity 4/729 84/18639 0.0476190476190476 1.217519106408 0.417797504345266 0.856548509434499 GO:0004860 protein kinase inhibitor activity 4/729 84/18639 0.0476190476190476 1.217519106408 0.417797504345266 0.856548509434499 GO:0180051 translation factor activity 4/729 84/18639 0.0476190476190476 1.217519106408 0.417797504345266 0.856548509434499 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3/729 60/18639 0.05 1.2783950617284 0.418246307121461 0.856548509434499 GO:0003713 transcription coactivator activity 11/729 256/18639 0.04296875 1.09862075617284 0.418520597492556 0.856548509434499 GO:0051087 protein-folding chaperone binding 6/729 134/18639 0.0447761194029851 1.14483139856274 0.427191847560469 0.856548509434499 GO:0023023 MHC protein complex binding 2/729 37/18639 0.0540540540540541 1.38204871538205 0.427494937981163 0.856548509434499 GO:0004065 arylsulfatase activity 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0005344 oxygen carrier activity 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0005347 ATP transmembrane transporter activity 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0005545 1-phosphatidylinositol binding 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0008195 phosphatidate phosphatase activity 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0008331 high voltage-gated calcium channel activity 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0008474 palmitoyl-(protein) hydrolase activity 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0015926 glucosidase activity 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0019992 diacylglycerol binding 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0032036 myosin heavy chain binding 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0034236 protein kinase A catalytic subunit binding 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0042043 neurexin family protein binding 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0044548 S100 protein binding 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0061665 SUMO ligase activity 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0098599 palmitoyl hydrolase activity 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0098821 BMP receptor activity 1/729 14/18639 0.0714285714285714 1.82627865961199 0.428079929141249 0.856548509434499 GO:0016836 hydro-lyase activity 3/729 61/18639 0.0491803278688525 1.25743776563449 0.428734270028439 0.856548509434499 GO:0000146 microfilament motor activity 2/729 38/18639 0.0526315789473684 1.34567901234568 0.440970501207214 0.866494430250139 GO:0005501 retinoid binding 2/729 38/18639 0.0526315789473684 1.34567901234568 0.440970501207214 0.866494430250139 GO:0019840 isoprenoid binding 2/729 38/18639 0.0526315789473684 1.34567901234568 0.440970501207214 0.866494430250139 GO:0022824 transmitter-gated monoatomic ion channel activity 3/729 63/18639 0.0476190476190476 1.217519106408 0.449500291687454 0.866494430250139 GO:0022835 transmitter-gated channel activity 3/729 63/18639 0.0476190476190476 1.217519106408 0.449500291687454 0.866494430250139 GO:0000774 adenyl-nucleotide exchange factor activity 1/729 15/18639 0.0666666666666667 1.70452674897119 0.450465418089224 0.866494430250139 GO:0004089 carbonate dehydratase activity 1/729 15/18639 0.0666666666666667 1.70452674897119 0.450465418089224 0.866494430250139 GO:0004559 alpha-mannosidase activity 1/729 15/18639 0.0666666666666667 1.70452674897119 0.450465418089224 0.866494430250139 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/729 15/18639 0.0666666666666667 1.70452674897119 0.450465418089224 0.866494430250139 GO:0008242 omega peptidase activity 1/729 15/18639 0.0666666666666667 1.70452674897119 0.450465418089224 0.866494430250139 GO:0016846 carbon-sulfur lyase activity 1/729 15/18639 0.0666666666666667 1.70452674897119 0.450465418089224 0.866494430250139 GO:0034483 heparan sulfate sulfotransferase activity 1/729 15/18639 0.0666666666666667 1.70452674897119 0.450465418089224 0.866494430250139 GO:0042809 nuclear vitamin D receptor binding 1/729 15/18639 0.0666666666666667 1.70452674897119 0.450465418089224 0.866494430250139 GO:0045504 dynein heavy chain binding 1/729 15/18639 0.0666666666666667 1.70452674897119 0.450465418089224 0.866494430250139 GO:0050700 CARD domain binding 1/729 15/18639 0.0666666666666667 1.70452674897119 0.450465418089224 0.866494430250139 GO:0050780 dopamine receptor binding 1/729 15/18639 0.0666666666666667 1.70452674897119 0.450465418089224 0.866494430250139 GO:0141050 histone H3K deacetylase activity 1/729 15/18639 0.0666666666666667 1.70452674897119 0.450465418089224 0.866494430250139 GO:0141051 histone H4K deacetylase activity 1/729 15/18639 0.0666666666666667 1.70452674897119 0.450465418089224 0.866494430250139 GO:0000217 DNA secondary structure binding 2/729 39/18639 0.0512820512820513 1.31117442228553 0.454269356470577 0.870215577930262 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 2/729 39/18639 0.0512820512820513 1.31117442228553 0.454269356470577 0.870215577930262 GO:0030331 nuclear estrogen receptor binding 2/729 40/18639 0.05 1.2783950617284 0.467384703336398 0.878534239371164 GO:0071949 FAD binding 2/729 40/18639 0.05 1.2783950617284 0.467384703336398 0.878534239371164 GO:0000062 fatty-acyl-CoA binding 1/729 16/18639 0.0625 1.59799382716049 0.471975872890177 0.878534239371164 GO:0003688 DNA replication origin binding 1/729 16/18639 0.0625 1.59799382716049 0.471975872890177 0.878534239371164 GO:0004708 MAP kinase kinase activity 1/729 16/18639 0.0625 1.59799382716049 0.471975872890177 0.878534239371164 GO:0005521 lamin binding 1/729 16/18639 0.0625 1.59799382716049 0.471975872890177 0.878534239371164 GO:0015385 sodium:proton antiporter activity 1/729 16/18639 0.0625 1.59799382716049 0.471975872890177 0.878534239371164 GO:0015923 mannosidase activity 1/729 16/18639 0.0625 1.59799382716049 0.471975872890177 0.878534239371164 GO:0017070 U6 snRNA binding 1/729 16/18639 0.0625 1.59799382716049 0.471975872890177 0.878534239371164 GO:0030275 LRR domain binding 1/729 16/18639 0.0625 1.59799382716049 0.471975872890177 0.878534239371164 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/729 16/18639 0.0625 1.59799382716049 0.471975872890177 0.878534239371164 GO:0034450 ubiquitin-ubiquitin ligase activity 1/729 16/18639 0.0625 1.59799382716049 0.471975872890177 0.878534239371164 GO:0043023 ribosomal large subunit binding 1/729 16/18639 0.0625 1.59799382716049 0.471975872890177 0.878534239371164 GO:0140327 flippase activity 1/729 16/18639 0.0625 1.59799382716049 0.471975872890177 0.878534239371164 GO:0046982 protein heterodimerization activity 15/729 369/18639 0.040650406504065 1.03934557864097 0.476591550191673 0.878534239371164 GO:0001530 lipopolysaccharide binding 2/729 41/18639 0.0487804878048781 1.24721469436917 0.480310541873951 0.878534239371164 GO:0005543 phospholipid binding 20/729 497/18639 0.0402414486921529 1.0288893856969 0.480564323389486 0.878534239371164 GO:1990782 protein tyrosine kinase binding 5/729 117/18639 0.0427350427350427 1.09264535190461 0.484751503326194 0.878534239371164 GO:0052689 carboxylic ester hydrolase activity 4/729 92/18639 0.0434782608695652 1.11164787976382 0.48724929090518 0.878534239371164 GO:0042054 histone methyltransferase activity 3/729 67/18639 0.0447761194029851 1.14483139856274 0.49005641406491 0.878534239371164 GO:0004550 nucleoside diphosphate kinase activity 1/729 17/18639 0.0588235294117647 1.5039941902687 0.492645452907525 0.878534239371164 GO:0004659 prenyltransferase activity 1/729 17/18639 0.0588235294117647 1.5039941902687 0.492645452907525 0.878534239371164 GO:0005092 GDP-dissociation inhibitor activity 1/729 17/18639 0.0588235294117647 1.5039941902687 0.492645452907525 0.878534239371164 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/729 17/18639 0.0588235294117647 1.5039941902687 0.492645452907525 0.878534239371164 GO:0015278 intracellularly gated calcium channel activity 1/729 17/18639 0.0588235294117647 1.5039941902687 0.492645452907525 0.878534239371164 GO:0016018 cyclosporin A binding 1/729 17/18639 0.0588235294117647 1.5039941902687 0.492645452907525 0.878534239371164 GO:0016805 dipeptidase activity 1/729 17/18639 0.0588235294117647 1.5039941902687 0.492645452907525 0.878534239371164 GO:0031489 myosin V binding 1/729 17/18639 0.0588235294117647 1.5039941902687 0.492645452907525 0.878534239371164 GO:0046965 nuclear retinoid X receptor binding 1/729 17/18639 0.0588235294117647 1.5039941902687 0.492645452907525 0.878534239371164 GO:0048038 quinone binding 1/729 17/18639 0.0588235294117647 1.5039941902687 0.492645452907525 0.878534239371164 GO:0070402 NADPH binding 1/729 17/18639 0.0588235294117647 1.5039941902687 0.492645452907525 0.878534239371164 GO:1901567 fatty acid derivative binding 1/729 17/18639 0.0588235294117647 1.5039941902687 0.492645452907525 0.878534239371164 GO:0016859 cis-trans isomerase activity 2/729 42/18639 0.0476190476190476 1.217519106408 0.493041620593019 0.878534239371164 GO:0031492 nucleosomal DNA binding 2/729 42/18639 0.0476190476190476 1.217519106408 0.493041620593019 0.878534239371164 GO:0035198 miRNA binding 2/729 42/18639 0.0476190476190476 1.217519106408 0.493041620593019 0.878534239371164 GO:0048487 beta-tubulin binding 2/729 42/18639 0.0476190476190476 1.217519106408 0.493041620593019 0.878534239371164 GO:0044389 ubiquitin-like protein ligase binding 13/729 322/18639 0.0403726708074534 1.03224445978069 0.493526753159097 0.878534239371164 GO:0051219 phosphoprotein binding 4/729 93/18639 0.043010752688172 1.09969467675561 0.495705666242692 0.879749472959862 GO:0019903 protein phosphatase binding 6/729 144/18639 0.0416666666666667 1.065329218107 0.496099326857065 0.879749472959862 GO:0019001 guanyl nucleotide binding 16/729 400/18639 0.04 1.02271604938272 0.499621569987712 0.879904225979903 GO:0032561 guanyl ribonucleotide binding 16/729 400/18639 0.04 1.02271604938272 0.499621569987712 0.879904225979903 GO:0003777 microtubule motor activity 3/729 68/18639 0.0441176470588235 1.12799564270153 0.499967062882244 0.879904225979903 GO:0030145 manganese ion binding 3/729 68/18639 0.0441176470588235 1.12799564270153 0.499967062882244 0.879904225979903 GO:0016791 phosphatase activity 11/729 273/18639 0.0402930402930403 1.03020847465292 0.503335730138909 0.880626636765866 GO:0008200 ion channel inhibitor activity 2/729 43/18639 0.0465116279069767 1.18920470858455 0.505573387219172 0.880626636765866 GO:0032182 ubiquitin-like protein binding 5/729 120/18639 0.0416666666666667 1.065329218107 0.507127985663529 0.880626636765866 GO:0016279 protein-lysine N-methyltransferase activity 3/729 69/18639 0.0434782608695652 1.11164787976382 0.509778854739116 0.880626636765866 GO:0000900 mRNA regulatory element binding translation repressor activity 1/729 18/18639 0.0555555555555556 1.42043895747599 0.512506985762772 0.880626636765866 GO:0008409 5'-3' exonuclease activity 1/729 18/18639 0.0555555555555556 1.42043895747599 0.512506985762772 0.880626636765866 GO:0015280 ligand-gated sodium channel activity 1/729 18/18639 0.0555555555555556 1.42043895747599 0.512506985762772 0.880626636765866 GO:0017128 phospholipid scramblase activity 1/729 18/18639 0.0555555555555556 1.42043895747599 0.512506985762772 0.880626636765866 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/729 18/18639 0.0555555555555556 1.42043895747599 0.512506985762772 0.880626636765866 GO:0051082 unfolded protein binding 5/729 121/18639 0.0413223140495868 1.05652484440363 0.514500970990629 0.880626636765866 GO:0001223 transcription coactivator binding 2/729 44/18639 0.0454545454545455 1.162177328844 0.517901942166008 0.880626636765866 GO:0016248 channel inhibitor activity 2/729 44/18639 0.0454545454545455 1.162177328844 0.517901942166008 0.880626636765866 GO:0016790 thiolester hydrolase activity 2/729 44/18639 0.0454545454545455 1.162177328844 0.517901942166008 0.880626636765866 GO:0016278 lysine N-methyltransferase activity 3/729 70/18639 0.0428571428571429 1.0957671957672 0.519488490211742 0.880626636765866 GO:0004896 cytokine receptor activity 4/729 96/18639 0.0416666666666667 1.065329218107 0.52070641063411 0.880626636765866 GO:0022804 active transmembrane transporter activity 18/729 457/18639 0.0393873085339169 1.00705081449064 0.522160711683162 0.880626636765866 GO:0001217 DNA-binding transcription repressor activity 11/729 278/18639 0.039568345323741 1.01167954525269 0.527745085785438 0.880626636765866 GO:0030594 neurotransmitter receptor activity 4/729 97/18639 0.0412371134020619 1.05434644266259 0.528909109270798 0.880626636765866 GO:0008009 chemokine activity 2/729 45/18639 0.0444444444444444 1.1363511659808 0.530023994569146 0.880626636765866 GO:0046915 transition metal ion transmembrane transporter activity 2/729 45/18639 0.0444444444444444 1.1363511659808 0.530023994569146 0.880626636765866 GO:0140303 intramembrane lipid transporter activity 2/729 45/18639 0.0444444444444444 1.1363511659808 0.530023994569146 0.880626636765866 GO:0141110 transporter inhibitor activity 2/729 45/18639 0.0444444444444444 1.1363511659808 0.530023994569146 0.880626636765866 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/729 19/18639 0.0526315789473684 1.34567901234568 0.531592019186269 0.880626636765866 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/729 19/18639 0.0526315789473684 1.34567901234568 0.531592019186269 0.880626636765866 GO:0008381 mechanosensitive monoatomic ion channel activity 1/729 19/18639 0.0526315789473684 1.34567901234568 0.531592019186269 0.880626636765866 GO:0022840 leak channel activity 1/729 19/18639 0.0526315789473684 1.34567901234568 0.531592019186269 0.880626636765866 GO:0022842 narrow pore channel activity 1/729 19/18639 0.0526315789473684 1.34567901234568 0.531592019186269 0.880626636765866 GO:0031420 alkali metal ion binding 1/729 19/18639 0.0526315789473684 1.34567901234568 0.531592019186269 0.880626636765866 GO:0042577 lipid phosphatase activity 1/729 19/18639 0.0526315789473684 1.34567901234568 0.531592019186269 0.880626636765866 GO:0050145 nucleoside monophosphate kinase activity 1/729 19/18639 0.0526315789473684 1.34567901234568 0.531592019186269 0.880626636765866 GO:0120227 acyl-CoA binding 1/729 19/18639 0.0526315789473684 1.34567901234568 0.531592019186269 0.880626636765866 GO:0140036 ubiquitin-modified protein reader activity 1/729 19/18639 0.0526315789473684 1.34567901234568 0.531592019186269 0.880626636765866 GO:1990380 K48-linked deubiquitinase activity 1/729 19/18639 0.0526315789473684 1.34567901234568 0.531592019186269 0.880626636765866 GO:0140996 histone H3 kinase activity 14/729 357/18639 0.0392156862745098 1.00266279351247 0.534622833176132 0.884074347579004 GO:0008170 N-methyltransferase activity 4/729 98/18639 0.0408163265306122 1.04358780549257 0.537042631163682 0.884325432998213 GO:0004180 carboxypeptidase activity 2/729 46/18639 0.0434782608695652 1.11164787976382 0.54193682075319 0.884325432998213 GO:0030276 clathrin binding 2/729 46/18639 0.0434782608695652 1.11164787976382 0.54193682075319 0.884325432998213 GO:0035173 histone kinase activity 14/729 360/18639 0.0388888888888889 0.994307270233196 0.54739363571113 0.884325432998213 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 3/729 73/18639 0.0410958904109589 1.05073566717402 0.547975111258957 0.884325432998213 GO:0001972 retinoic acid binding 1/729 20/18639 0.05 1.2783950617284 0.549930870851855 0.884325432998213 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/729 20/18639 0.05 1.2783950617284 0.549930870851855 0.884325432998213 GO:0015095 magnesium ion transmembrane transporter activity 1/729 20/18639 0.05 1.2783950617284 0.549930870851855 0.884325432998213 GO:0016004 phospholipase activator activity 1/729 20/18639 0.05 1.2783950617284 0.549930870851855 0.884325432998213 GO:0016408 C-acyltransferase activity 1/729 20/18639 0.05 1.2783950617284 0.549930870851855 0.884325432998213 GO:0016505 peptidase activator activity involved in apoptotic process 1/729 20/18639 0.05 1.2783950617284 0.549930870851855 0.884325432998213 GO:0001784 phosphotyrosine residue binding 2/729 47/18639 0.0425531914893617 1.08799579721566 0.553638225009021 0.884325432998213 GO:0005504 fatty acid binding 2/729 47/18639 0.0425531914893617 1.08799579721566 0.553638225009021 0.884325432998213 GO:0140938 histone H3 methyltransferase activity 2/729 47/18639 0.0425531914893617 1.08799579721566 0.553638225009021 0.884325432998213 GO:0031491 nucleosome binding 3/729 74/18639 0.0405405405405405 1.03653653653654 0.557247935010799 0.884325432998213 GO:0019783 ubiquitin-like protein peptidase activity 5/729 127/18639 0.0393700787401575 1.00661028482551 0.557712460634463 0.884325432998213 GO:0042826 histone deacetylase binding 5/729 127/18639 0.0393700787401575 1.00661028482551 0.557712460634463 0.884325432998213 GO:0005506 iron ion binding 6/729 154/18639 0.038961038961039 0.996151996151996 0.561975784916606 0.884325432998213 GO:0032266 phosphatidylinositol-3-phosphate binding 2/729 48/18639 0.0416666666666667 1.065329218107 0.565126502564619 0.884325432998213 GO:0044183 protein folding chaperone 3/729 75/18639 0.04 1.02271604938272 0.566405642775765 0.884325432998213 GO:0001846 opsonin binding 1/729 21/18639 0.0476190476190476 1.217519106408 0.567552676273682 0.884325432998213 GO:0009975 cyclase activity 1/729 21/18639 0.0476190476190476 1.217519106408 0.567552676273682 0.884325432998213 GO:0010314 phosphatidylinositol-5-phosphate binding 1/729 21/18639 0.0476190476190476 1.217519106408 0.567552676273682 0.884325432998213 GO:0061891 calcium ion sensor activity 1/729 21/18639 0.0476190476190476 1.217519106408 0.567552676273682 0.884325432998213 GO:0015171 amino acid transmembrane transporter activity 4/729 102/18639 0.0392156862745098 1.00266279351247 0.568845508632746 0.884325432998213 GO:0019207 kinase regulator activity 11/729 287/18639 0.0383275261324042 0.97995440271863 0.570640526543254 0.884325432998213 GO:0035254 glutamate receptor binding 2/729 49/18639 0.0408163265306122 1.04358780549257 0.576400404638208 0.884325432998213 GO:0003730 mRNA 3'-UTR binding 10/729 262/18639 0.0381679389312977 0.975874092922439 0.576695205202355 0.884325432998213 GO:0005261 monoatomic cation channel activity 13/729 341/18639 0.0381231671554252 0.974729372578835 0.577587327871128 0.884325432998213 GO:0051540 metal cluster binding 3/729 77/18639 0.038961038961039 0.996151996151996 0.58436815336526 0.884325432998213 GO:0004407 histone deacetylase activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0005243 gap junction channel activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0015377 chloride:monoatomic cation symporter activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0032931 histone H3K56 acetyltransferase activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0033558 protein lysine deacetylase activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0034062 5'-3' RNA polymerase activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0043992 histone H3K9 acetyltransferase activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0043993 histone H3K18 acetyltransferase activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0043994 histone H3K23 acetyltransferase activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0043999 histone H2AK5 acetyltransferase activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0044012 histone H2AK9 acetyltransferase activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0044014 histone H2BK5 acetyltransferase activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0044015 histone H2BK12 acetyltransferase activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0044016 histone H3K4 acetyltransferase activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0044017 histone H3K27 acetyltransferase activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0044018 histone H3K36 acetyltransferase activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0061133 endopeptidase activator activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0097747 RNA polymerase activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0140035 ubiquitin-like protein reader activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0140784 metal ion sensor activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0140908 histone H3K122 acetyltransferase activity 1/729 22/18639 0.0454545454545455 1.162177328844 0.584485434840472 0.884325432998213 GO:0032813 tumor necrosis factor receptor superfamily binding 2/729 50/18639 0.04 1.02271604938272 0.587459105467826 0.884325432998213 GO:0046873 metal ion transmembrane transporter activity 17/729 450/18639 0.0377777777777778 0.965898491083676 0.593605150491621 0.884325432998213 GO:0016830 carbon-carbon lyase activity 2/729 51/18639 0.0392156862745098 1.00266279351247 0.598302171216533 0.884325432998213 GO:0000295 adenine nucleotide transmembrane transporter activity 1/729 23/18639 0.0434782608695652 1.11164787976382 0.600756054059535 0.884325432998213 GO:0005212 structural constituent of eye lens 1/729 23/18639 0.0434782608695652 1.11164787976382 0.600756054059535 0.884325432998213 GO:0008171 O-methyltransferase activity 1/729 23/18639 0.0434782608695652 1.11164787976382 0.600756054059535 0.884325432998213 GO:0016849 phosphorus-oxygen lyase activity 1/729 23/18639 0.0434782608695652 1.11164787976382 0.600756054059535 0.884325432998213 GO:0031681 G-protein beta-subunit binding 1/729 23/18639 0.0434782608695652 1.11164787976382 0.600756054059535 0.884325432998213 GO:0044013 histone H2B acetyltransferase activity 1/729 23/18639 0.0434782608695652 1.11164787976382 0.600756054059535 0.884325432998213 GO:0070577 lysine-acetylated histone binding 1/729 23/18639 0.0434782608695652 1.11164787976382 0.600756054059535 0.884325432998213 GO:0140103 catalytic activity, acting on a glycoprotein 1/729 23/18639 0.0434782608695652 1.11164787976382 0.600756054059535 0.884325432998213 GO:0016835 carbon-oxygen lyase activity 3/729 79/18639 0.0379746835443038 0.97093295827473 0.601849478834163 0.884325432998213 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 10/729 268/18639 0.0373134328358209 0.954026165468951 0.605492418973882 0.884325432998213 GO:0019888 protein phosphatase regulator activity 4/729 107/18639 0.0373831775700935 0.955809391946464 0.606829335093502 0.884325432998213 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 13/729 349/18639 0.0372492836676218 0.952386005872157 0.611264795733338 0.884325432998213 GO:0004622 lysophospholipase activity 1/729 24/18639 0.0416666666666667 1.065329218107 0.616390392080087 0.884325432998213 GO:0004806 triacylglycerol lipase activity 1/729 24/18639 0.0416666666666667 1.065329218107 0.616390392080087 0.884325432998213 GO:0005315 phosphate transmembrane transporter activity 1/729 24/18639 0.0416666666666667 1.065329218107 0.616390392080087 0.884325432998213 GO:0015149 hexose transmembrane transporter activity 1/729 24/18639 0.0416666666666667 1.065329218107 0.616390392080087 0.884325432998213 GO:0015295 solute:proton symporter activity 1/729 24/18639 0.0416666666666667 1.065329218107 0.616390392080087 0.884325432998213 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/729 24/18639 0.0416666666666667 1.065329218107 0.616390392080087 0.884325432998213 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/729 24/18639 0.0416666666666667 1.065329218107 0.616390392080087 0.884325432998213 GO:0043998 histone H2A acetyltransferase activity 1/729 24/18639 0.0416666666666667 1.065329218107 0.616390392080087 0.884325432998213 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/729 24/18639 0.0416666666666667 1.065329218107 0.616390392080087 0.884325432998213 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/729 24/18639 0.0416666666666667 1.065329218107 0.616390392080087 0.884325432998213 GO:0050431 transforming growth factor beta binding 1/729 24/18639 0.0416666666666667 1.065329218107 0.616390392080087 0.884325432998213 GO:0055056 D-glucose transmembrane transporter activity 1/729 24/18639 0.0416666666666667 1.065329218107 0.616390392080087 0.884325432998213 GO:0060229 lipase activator activity 1/729 24/18639 0.0416666666666667 1.065329218107 0.616390392080087 0.884325432998213 GO:0140033 acetylation-dependent protein binding 1/729 24/18639 0.0416666666666667 1.065329218107 0.616390392080087 0.884325432998213 GO:0019902 phosphatase binding 7/729 190/18639 0.0368421052631579 0.941975308641975 0.617348803870832 0.884325432998213 GO:0044325 transmembrane transporter binding 5/729 136/18639 0.0367647058823529 0.939996368917938 0.618707568964432 0.884325432998213 GO:0030971 receptor tyrosine kinase binding 3/729 81/18639 0.037037037037037 0.946959304983996 0.618839406410276 0.884325432998213 GO:0005544 calcium-dependent phospholipid binding 2/729 53/18639 0.0377358490566038 0.964826461681808 0.619341447546049 0.884325432998213 GO:0008146 sulfotransferase activity 2/729 53/18639 0.0377358490566038 0.964826461681808 0.619341447546049 0.884325432998213 GO:0051018 protein kinase A binding 2/729 53/18639 0.0377358490566038 0.964826461681808 0.619341447546049 0.884325432998213 GO:0005525 GTP binding 14/729 378/18639 0.037037037037037 0.946959304983996 0.621160846456268 0.884325432998213 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 2/729 54/18639 0.037037037037037 0.946959304983996 0.629538494596545 0.884325432998213 GO:0000030 mannosyltransferase activity 1/729 25/18639 0.04 1.02271604938272 0.631413298562688 0.884325432998213 GO:0004709 MAP kinase kinase kinase activity 1/729 25/18639 0.04 1.02271604938272 0.631413298562688 0.884325432998213 GO:0005537 D-mannose binding 1/729 25/18639 0.04 1.02271604938272 0.631413298562688 0.884325432998213 GO:0008139 nuclear localization sequence binding 1/729 25/18639 0.04 1.02271604938272 0.631413298562688 0.884325432998213 GO:0015271 outward rectifier potassium channel activity 1/729 25/18639 0.04 1.02271604938272 0.631413298562688 0.884325432998213 GO:0015662 P-type ion transporter activity 1/729 25/18639 0.04 1.02271604938272 0.631413298562688 0.884325432998213 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/729 25/18639 0.04 1.02271604938272 0.631413298562688 0.884325432998213 GO:0017025 TBP-class protein binding 1/729 25/18639 0.04 1.02271604938272 0.631413298562688 0.884325432998213 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/729 25/18639 0.04 1.02271604938272 0.631413298562688 0.884325432998213 GO:0019707 protein-cysteine S-acyltransferase activity 1/729 25/18639 0.04 1.02271604938272 0.631413298562688 0.884325432998213 GO:0042974 nuclear retinoic acid receptor binding 1/729 25/18639 0.04 1.02271604938272 0.631413298562688 0.884325432998213 GO:0140358 P-type transmembrane transporter activity 1/729 25/18639 0.04 1.02271604938272 0.631413298562688 0.884325432998213 GO:0141003 histone H2AX kinase activity 13/729 354/18639 0.0367231638418079 0.9389342261282 0.631661023570152 0.884325432998213 GO:0030165 PDZ domain binding 3/729 83/18639 0.036144578313253 0.924141008478358 0.635330439712315 0.888127086144392 GO:0031625 ubiquitin protein ligase binding 11/729 302/18639 0.0364238410596026 0.93128117079552 0.638236455537092 0.889474995319336 GO:0005112 Notch binding 1/729 26/18639 0.0384615384615385 0.98338081671415 0.645848653959045 0.889474995319336 GO:0008143 poly(A) binding 1/729 26/18639 0.0384615384615385 0.98338081671415 0.645848653959045 0.889474995319336 GO:0008198 ferrous iron binding 1/729 26/18639 0.0384615384615385 0.98338081671415 0.645848653959045 0.889474995319336 GO:0015145 monosaccharide transmembrane transporter activity 1/729 26/18639 0.0384615384615385 0.98338081671415 0.645848653959045 0.889474995319336 GO:0015216 purine nucleotide transmembrane transporter activity 1/729 26/18639 0.0384615384615385 0.98338081671415 0.645848653959045 0.889474995319336 GO:0043548 phosphatidylinositol 3-kinase binding 1/729 26/18639 0.0384615384615385 0.98338081671415 0.645848653959045 0.889474995319336 GO:0051139 metal cation:proton antiporter activity 1/729 26/18639 0.0384615384615385 0.98338081671415 0.645848653959045 0.889474995319336 GO:0070412 R-SMAD binding 1/729 26/18639 0.0384615384615385 0.98338081671415 0.645848653959045 0.889474995319336 GO:0097602 cullin family protein binding 1/729 26/18639 0.0384615384615385 0.98338081671415 0.645848653959045 0.889474995319336 GO:0003924 GTPase activity 12/729 331/18639 0.0362537764350453 0.926932975271344 0.647091648497471 0.889870494462548 GO:0030170 pyridoxal phosphate binding 2/729 56/18639 0.0357142857142857 0.913139329805997 0.649291669225032 0.891578973522868 GO:0003712 transcription coregulator activity 18/729 495/18639 0.0363636363636364 0.929741863075196 0.65867985743675 0.90058470405091 GO:0070279 vitamin B6 binding 2/729 57/18639 0.0350877192982456 0.897119341563786 0.658850273582613 0.90058470405091 GO:0015252 proton channel activity 1/729 27/18639 0.037037037037037 0.946959304983996 0.659719407263932 0.90058470405091 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/729 27/18639 0.037037037037037 0.946959304983996 0.659719407263932 0.90058470405091 GO:0022843 voltage-gated monoatomic cation channel activity 5/729 143/18639 0.034965034965035 0.893982560649227 0.662536621125104 0.903106287360867 GO:0016829 lyase activity 7/729 200/18639 0.035 0.894876543209877 0.670336305101398 0.903459175855612 GO:0031267 small GTPase binding 10/729 283/18639 0.0353356890459364 0.903459407581905 0.673010892157711 0.903459175855612 GO:0019789 SUMO transferase activity 1/729 28/18639 0.0357142857142857 0.913139329805997 0.673047612298565 0.903459175855612 GO:0036408 histone H3K14 acetyltransferase activity 1/729 28/18639 0.0357142857142857 0.913139329805997 0.673047612298565 0.903459175855612 GO:0046966 nuclear thyroid hormone receptor binding 1/729 28/18639 0.0357142857142857 0.913139329805997 0.673047612298565 0.903459175855612 GO:0051019 mitogen-activated protein kinase binding 1/729 28/18639 0.0357142857142857 0.913139329805997 0.673047612298565 0.903459175855612 GO:0051119 sugar transmembrane transporter activity 1/729 28/18639 0.0357142857142857 0.913139329805997 0.673047612298565 0.903459175855612 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/729 28/18639 0.0357142857142857 0.913139329805997 0.673047612298565 0.903459175855612 GO:0097718 disordered domain specific binding 1/729 28/18639 0.0357142857142857 0.913139329805997 0.673047612298565 0.903459175855612 GO:0004197 cysteine-type endopeptidase activity 3/729 88/18639 0.0340909090909091 0.871632996632997 0.674348039543029 0.903459175855612 GO:0140030 modification-dependent protein binding 6/729 173/18639 0.0346820809248555 0.886748019695997 0.674374191817607 0.903459175855612 GO:0008194 UDP-glycosyltransferase activity 5/729 145/18639 0.0344827586206897 0.881651766709238 0.674440523329377 0.903459175855612 GO:0019208 phosphatase regulator activity 4/729 117/18639 0.0341880341880342 0.874116281523689 0.676353250501689 0.904719649737173 GO:0001786 phosphatidylserine binding 2/729 59/18639 0.0338983050847458 0.866708516426031 0.677339384728685 0.904738833834155 GO:0010484 histone H3 acetyltransferase activity 1/729 29/18639 0.0344827586206897 0.881651766709238 0.685854462582502 0.909587613481922 GO:0016417 S-acyltransferase activity 1/729 29/18639 0.0344827586206897 0.881651766709238 0.685854462582502 0.909587613481922 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/729 29/18639 0.0344827586206897 0.881651766709238 0.685854462582502 0.909587613481922 GO:0051861 glycolipid binding 1/729 29/18639 0.0344827586206897 0.881651766709238 0.685854462582502 0.909587613481922 GO:0106222 lncRNA binding 1/729 29/18639 0.0344827586206897 0.881651766709238 0.685854462582502 0.909587613481922 GO:0051020 GTPase binding 11/729 315/18639 0.0349206349206349 0.892847344699197 0.691967993449173 0.915475017513113 GO:0019905 syntaxin binding 2/729 61/18639 0.0327868852459016 0.838291843756325 0.695003776538536 0.915475017513113 GO:0072341 modified amino acid binding 3/729 91/18639 0.032967032967033 0.842897842897843 0.696238316705414 0.915475017513113 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/729 30/18639 0.0333333333333333 0.852263374485597 0.698160324848883 0.915475017513113 GO:0015215 nucleotide transmembrane transporter activity 1/729 30/18639 0.0333333333333333 0.852263374485597 0.698160324848883 0.915475017513113 GO:0043995 histone H4K5 acetyltransferase activity 1/729 30/18639 0.0333333333333333 0.852263374485597 0.698160324848883 0.915475017513113 GO:0043996 histone H4K8 acetyltransferase activity 1/729 30/18639 0.0333333333333333 0.852263374485597 0.698160324848883 0.915475017513113 GO:0043997 histone H4K12 acetyltransferase activity 1/729 30/18639 0.0333333333333333 0.852263374485597 0.698160324848883 0.915475017513113 GO:0019842 vitamin binding 5/729 150/18639 0.0333333333333333 0.852263374485597 0.702964733209535 0.919601644883127 GO:0043178 alcohol binding 3/729 92/18639 0.0326086956521739 0.833735909822866 0.703282890608793 0.919601644883127 GO:0005164 tumor necrosis factor receptor binding 1/729 31/18639 0.032258064516129 0.824771007566707 0.709984771255738 0.923178522400967 GO:0005184 neuropeptide hormone activity 1/729 31/18639 0.032258064516129 0.824771007566707 0.709984771255738 0.923178522400967 GO:0005452 solute:inorganic anion antiporter activity 1/729 31/18639 0.032258064516129 0.824771007566707 0.709984771255738 0.923178522400967 GO:0070273 phosphatidylinositol-4-phosphate binding 1/729 31/18639 0.032258064516129 0.824771007566707 0.709984771255738 0.923178522400967 GO:0015106 bicarbonate transmembrane transporter activity 1/729 32/18639 0.03125 0.798996913580247 0.72134661034401 0.930157471233066 GO:0030515 snoRNA binding 1/729 32/18639 0.03125 0.798996913580247 0.72134661034401 0.930157471233066 GO:0071813 lipoprotein particle binding 1/729 32/18639 0.03125 0.798996913580247 0.72134661034401 0.930157471233066 GO:0071814 protein-lipid complex binding 1/729 32/18639 0.03125 0.798996913580247 0.72134661034401 0.930157471233066 GO:0120015 sterol transfer activity 1/729 32/18639 0.03125 0.798996913580247 0.72134661034401 0.930157471233066 GO:0160041 neuropeptide activity 1/729 32/18639 0.03125 0.798996913580247 0.72134661034401 0.930157471233066 GO:0008276 protein methyltransferase activity 3/729 95/18639 0.0315789473684211 0.807407407407407 0.723667062554874 0.931858969901228 GO:0030695 GTPase regulator activity 17/729 489/18639 0.0347648261758691 0.888863642101543 0.725449403182407 0.932863804368537 GO:0060589 nucleoside-triphosphatase regulator activity 17/729 490/18639 0.0346938775510204 0.887049634668682 0.728453845145752 0.93543521355958 GO:0016407 acetyltransferase activity 3/729 96/18639 0.03125 0.798996913580247 0.73021418035877 0.936404134867789 GO:0071889 14-3-3 protein binding 1/729 33/18639 0.0303030303030303 0.774784885895997 0.732263916791004 0.936452893588496 GO:0140416 transcription regulator inhibitor activity 1/729 33/18639 0.0303030303030303 0.774784885895997 0.732263916791004 0.936452893588496 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 4/729 128/18639 0.03125 0.798996913580247 0.742410180369384 0.940823330939598 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/729 34/18639 0.0294117647058824 0.75199709513435 0.742754060006061 0.940823330939598 GO:0016831 carboxy-lyase activity 1/729 34/18639 0.0294117647058824 0.75199709513435 0.742754060006061 0.940823330939598 GO:0030332 cyclin binding 1/729 34/18639 0.0294117647058824 0.75199709513435 0.742754060006061 0.940823330939598 GO:0051427 hormone receptor binding 1/729 34/18639 0.0294117647058824 0.75199709513435 0.742754060006061 0.940823330939598 GO:0090482 vitamin transmembrane transporter activity 1/729 34/18639 0.0294117647058824 0.75199709513435 0.742754060006061 0.940823330939598 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2/729 67/18639 0.0298507462686567 0.763220932375161 0.743234639423258 0.940823330939598 GO:0008234 cysteine-type peptidase activity 6/729 187/18639 0.0320855614973262 0.820360467419291 0.744279553410854 0.940823330939598 GO:0015631 tubulin binding 13/729 385/18639 0.0337662337662338 0.863331729998397 0.744776364019854 0.940823330939598 GO:0005548 phospholipid transporter activity 2/729 68/18639 0.0294117647058824 0.75199709513435 0.750606384166925 0.942571716828332 GO:1990841 promoter-specific chromatin binding 2/729 68/18639 0.0294117647058824 0.75199709513435 0.750606384166925 0.942571716828332 GO:0010485 histone H4 acetyltransferase activity 1/729 35/18639 0.0285714285714286 0.730511463844797 0.752833731613457 0.942571716828332 GO:0043015 gamma-tubulin binding 1/729 35/18639 0.0285714285714286 0.730511463844797 0.752833731613457 0.942571716828332 GO:0061631 ubiquitin conjugating enzyme activity 1/729 35/18639 0.0285714285714286 0.730511463844797 0.752833731613457 0.942571716828332 GO:0140566 histone reader activity 1/729 35/18639 0.0285714285714286 0.730511463844797 0.752833731613457 0.942571716828332 GO:0016298 lipase activity 4/729 130/18639 0.0307692307692308 0.78670465337132 0.753247429989559 0.942571716828332 GO:0008017 microtubule binding 9/729 276/18639 0.0326086956521739 0.833735909822866 0.756458741873881 0.945279843950758 GO:0008080 N-acetyltransferase activity 2/729 69/18639 0.0289855072463768 0.741098586509215 0.757795265642382 0.945279843950758 GO:0004190 aspartic-type endopeptidase activity 1/729 36/18639 0.0277777777777778 0.710219478737997 0.762518971865757 0.945279843950758 GO:0004869 cysteine-type endopeptidase inhibitor activity 1/729 36/18639 0.0277777777777778 0.710219478737997 0.762518971865757 0.945279843950758 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/729 36/18639 0.0277777777777778 0.710219478737997 0.762518971865757 0.945279843950758 GO:0005484 SNAP receptor activity 1/729 36/18639 0.0277777777777778 0.710219478737997 0.762518971865757 0.945279843950758 GO:0016409 palmitoyltransferase activity 1/729 36/18639 0.0277777777777778 0.710219478737997 0.762518971865757 0.945279843950758 GO:0016782 transferase activity, transferring sulphur-containing groups 2/729 70/18639 0.0285714285714286 0.730511463844797 0.764804288449165 0.94685211774757 GO:0140299 molecular sensor activity 2/729 71/18639 0.028169014084507 0.720222569987828 0.771636502138885 0.95174735969828 GO:0022829 wide pore channel activity 1/729 37/18639 0.027027027027027 0.691024357691024 0.771825195029217 0.95174735969828 GO:0070001 aspartic-type peptidase activity 1/729 37/18639 0.027027027027027 0.691024357691024 0.771825195029217 0.95174735969828 GO:0042379 chemokine receptor binding 2/729 72/18639 0.0277777777777778 0.710219478737997 0.778294993118081 0.957699968419319 GO:0042162 telomeric DNA binding 1/729 38/18639 0.0263157894736842 0.672839506172839 0.780767213781164 0.957699968419319 GO:0042887 amide transmembrane transporter activity 1/729 38/18639 0.0263157894736842 0.672839506172839 0.780767213781164 0.957699968419319 GO:0043531 ADP binding 1/729 38/18639 0.0263157894736842 0.672839506172839 0.780767213781164 0.957699968419319 GO:0019887 protein kinase regulator activity 8/729 255/18639 0.0313725490196078 0.802130234809973 0.784604047554815 0.960645063443624 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5/729 167/18639 0.029940119760479 0.765506024987063 0.786654567280533 0.960645063443624 GO:0016758 hexosyltransferase activity 6/729 197/18639 0.0304568527918782 0.778717804098515 0.78716428275544 0.960645063443624 GO:0004497 monooxygenase activity 3/729 106/18639 0.0283018867924528 0.723619846261356 0.789115553152103 0.960645063443624 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/729 39/18639 0.0256410256410256 0.655587211142767 0.789359262657758 0.960645063443624 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/729 39/18639 0.0256410256410256 0.655587211142767 0.789359262657758 0.960645063443624 GO:0015144 carbohydrate transmembrane transporter activity 1/729 40/18639 0.025 0.639197530864198 0.797615020589075 0.962727658421724 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 1/729 40/18639 0.025 0.639197530864198 0.797615020589075 0.962727658421724 GO:0071855 neuropeptide receptor binding 1/729 40/18639 0.025 0.639197530864198 0.797615020589075 0.962727658421724 GO:0140662 ATP-dependent protein folding chaperone 1/729 40/18639 0.025 0.639197530864198 0.797615020589075 0.962727658421724 GO:0030295 protein kinase activator activity 4/729 139/18639 0.0287769784172662 0.735766942001954 0.797699260724233 0.962727658421724 GO:0000287 magnesium ion binding 7/729 230/18639 0.0304347826086957 0.778153515834675 0.799943746052489 0.962727658421724 GO:0022836 gated channel activity 10/729 318/18639 0.0314465408805031 0.804022051401506 0.801360087553169 0.962727658421724 GO:0051536 iron-sulfur cluster binding 2/729 76/18639 0.0263157894736842 0.672839506172839 0.803254340716281 0.962727658421724 GO:0004620 phospholipase activity 3/729 109/18639 0.0275229357798165 0.703703703703704 0.80456242969634 0.962727658421724 GO:0016877 ligase activity, forming carbon-sulfur bonds 1/729 41/18639 0.024390243902439 0.623607347184583 0.805547632556953 0.962727658421724 GO:0017080 sodium channel regulator activity 1/729 41/18639 0.024390243902439 0.623607347184583 0.805547632556953 0.962727658421724 GO:0042287 MHC protein binding 1/729 41/18639 0.024390243902439 0.623607347184583 0.805547632556953 0.962727658421724 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/729 41/18639 0.024390243902439 0.623607347184583 0.805547632556953 0.962727658421724 GO:0140828 metal cation:monoatomic cation antiporter activity 1/729 41/18639 0.024390243902439 0.623607347184583 0.805547632556953 0.962727658421724 GO:0001216 DNA-binding transcription activator activity 16/729 491/18639 0.0325865580448065 0.833169897664127 0.806868157978276 0.963069557792019 GO:0005244 voltage-gated monoatomic ion channel activity 5/729 173/18639 0.0289017341040462 0.738956683079997 0.81141509040815 0.964574688244854 GO:0004402 histone acetyltransferase activity 1/729 42/18639 0.0238095238095238 0.608759553203998 0.813169730409732 0.964574688244854 GO:0004520 DNA endonuclease activity 1/729 42/18639 0.0238095238095238 0.608759553203998 0.813169730409732 0.964574688244854 GO:0019894 kinesin binding 1/729 42/18639 0.0238095238095238 0.608759553203998 0.813169730409732 0.964574688244854 GO:0003714 transcription corepressor activity 6/729 204/18639 0.0294117647058824 0.75199709513435 0.813774945343274 0.964574688244854 GO:0043022 ribosome binding 3/729 112/18639 0.0267857142857143 0.684854497354497 0.81904685705057 0.964574688244854 GO:0003735 structural constituent of ribosome 5/729 175/18639 0.0285714285714286 0.730511463844797 0.819141416042155 0.964574688244854 GO:0022832 voltage-gated channel activity 5/729 175/18639 0.0285714285714286 0.730511463844797 0.819141416042155 0.964574688244854 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/729 43/18639 0.0232558139534884 0.594602354292277 0.82049345286665 0.964574688244854 GO:0008375 acetylglucosaminyltransferase activity 1/729 43/18639 0.0232558139534884 0.594602354292277 0.82049345286665 0.964574688244854 GO:0019205 nucleobase-containing compound kinase activity 1/729 44/18639 0.0227272727272727 0.581088664421998 0.827530464743409 0.964574688244854 GO:0015293 symporter activity 4/729 146/18639 0.0273972602739726 0.700490444782682 0.827617667116801 0.964574688244854 GO:0008514 organic anion transmembrane transporter activity 8/729 269/18639 0.0297397769516729 0.760383679838451 0.830372337465725 0.964574688244854 GO:0015101 organic cation transmembrane transporter activity 2/729 81/18639 0.0246913580246914 0.631306203322664 0.830922556361303 0.964574688244854 GO:0033192 calmodulin-dependent protein phosphatase activity 2/729 81/18639 0.0246913580246914 0.631306203322664 0.830922556361303 0.964574688244854 GO:0140791 histone H2AXS140 phosphatase activity 2/729 81/18639 0.0246913580246914 0.631306203322664 0.830922556361303 0.964574688244854 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 2/729 81/18639 0.0246913580246914 0.631306203322664 0.830922556361303 0.964574688244854 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 2/729 81/18639 0.0246913580246914 0.631306203322664 0.830922556361303 0.964574688244854 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 2/729 81/18639 0.0246913580246914 0.631306203322664 0.830922556361303 0.964574688244854 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 2/729 81/18639 0.0246913580246914 0.631306203322664 0.830922556361303 0.964574688244854 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 2/729 81/18639 0.0246913580246914 0.631306203322664 0.830922556361303 0.964574688244854 GO:1990439 MAP kinase serine/threonine phosphatase activity 2/729 81/18639 0.0246913580246914 0.631306203322664 0.830922556361303 0.964574688244854 GO:0042605 peptide antigen binding 1/729 45/18639 0.0222222222222222 0.568175582990398 0.834291975429188 0.965529383841717 GO:0019209 kinase activator activity 4/729 148/18639 0.027027027027027 0.691024357691024 0.835460822720801 0.965529383841717 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 2/729 82/18639 0.024390243902439 0.623607347184583 0.836016928932131 0.965529383841717 GO:0033549 MAP kinase phosphatase activity 2/729 82/18639 0.024390243902439 0.623607347184583 0.836016928932131 0.965529383841717 GO:0015294 solute:monoatomic cation symporter activity 3/729 116/18639 0.0258620689655172 0.661238825031929 0.836930411128105 0.965529383841717 GO:0005216 monoatomic ion channel activity 14/729 448/18639 0.03125 0.798996913580247 0.839764840551754 0.967600329893172 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 2/729 83/18639 0.0240963855421687 0.616094005652239 0.840972150888176 0.967793661899743 GO:0017018 myosin phosphatase activity 2/729 84/18639 0.0238095238095238 0.608759553203998 0.845791295663588 0.972137896620741 GO:0061733 protein-lysine-acetyltransferase activity 1/729 47/18639 0.0212765957446809 0.543997898607828 0.847031159505844 0.972362527126931 GO:0050660 flavin adenine dinucleotide binding 2/729 86/18639 0.0232558139534884 0.594602354292277 0.855033508844673 0.979201150325307 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 15/729 484/18639 0.0309917355371901 0.792393633302724 0.855091874559049 0.979201150325307 GO:0016763 pentosyltransferase activity 1/729 49/18639 0.0204081632653061 0.521793902746284 0.858792229394541 0.981025233823702 GO:0060590 ATPase regulator activity 1/729 49/18639 0.0204081632653061 0.521793902746284 0.858792229394541 0.981025233823702 GO:0008528 G protein-coupled peptide receptor activity 3/729 122/18639 0.0245901639344262 0.628718882817244 0.860890034444512 0.982216448612549 GO:0140375 immune receptor activity 4/729 156/18639 0.0256410256410256 0.655587211142767 0.863905738392752 0.982528565227014 GO:0015605 organophosphate ester transmembrane transporter activity 1/729 50/18639 0.02 0.511358024691358 0.864329640086923 0.982528565227014 GO:0048020 CCR chemokine receptor binding 1/729 50/18639 0.02 0.511358024691358 0.864329640086923 0.982528565227014 GO:0003727 single-stranded RNA binding 2/729 89/18639 0.0224719101123595 0.574559578304897 0.867951390707594 0.98377196402344 GO:0005267 potassium channel activity 3/729 124/18639 0.0241935483870968 0.61857825567503 0.868161413799578 0.98377196402344 GO:0005048 signal sequence binding 1/729 51/18639 0.0196078431372549 0.501331396756233 0.86965018946433 0.98377196402344 GO:0016597 amino acid binding 1/729 51/18639 0.0196078431372549 0.501331396756233 0.86965018946433 0.98377196402344 GO:0030159 signaling receptor complex adaptor activity 1/729 52/18639 0.0192307692307692 0.491690408357075 0.874762359244861 0.985434792876041 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 2/729 91/18639 0.021978021978022 0.561931895265229 0.875967005508533 0.985434792876041 GO:0015079 potassium ion transmembrane transporter activity 4/729 160/18639 0.025 0.639197530864198 0.876478295147385 0.985434792876041 GO:0004864 protein phosphatase inhibitor activity 1/729 53/18639 0.0188679245283019 0.482413230840904 0.879674299854453 0.985434792876041 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/729 53/18639 0.0188679245283019 0.482413230840904 0.879674299854453 0.985434792876041 GO:0017046 peptide hormone binding 1/729 53/18639 0.0188679245283019 0.482413230840904 0.879674299854453 0.985434792876041 GO:0034212 protein N-acetyltransferase activity 1/729 53/18639 0.0188679245283019 0.482413230840904 0.879674299854453 0.985434792876041 GO:1901505 carbohydrate derivative transmembrane transporter activity 1/729 53/18639 0.0188679245283019 0.482413230840904 0.879674299854453 0.985434792876041 GO:0001653 peptide receptor activity 3/729 128/18639 0.0234375 0.599247685185185 0.881704814678563 0.985434792876041 GO:0031490 chromatin DNA binding 3/729 128/18639 0.0234375 0.599247685185185 0.881704814678563 0.985434792876041 GO:0016410 N-acyltransferase activity 2/729 94/18639 0.0212765957446809 0.543997898607828 0.887152286440431 0.987580487166462 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 6/729 229/18639 0.0262008733624454 0.669901342390425 0.887966963611796 0.987580487166462 GO:0016798 hydrolase activity, acting on glycosyl bonds 3/729 130/18639 0.0230769230769231 0.59002849002849 0.888000976414152 0.987580487166462 GO:0015081 sodium ion transmembrane transporter activity 4/729 164/18639 0.024390243902439 0.623607347184583 0.888033689482393 0.987580487166462 GO:0008374 O-acyltransferase activity 1/729 55/18639 0.0181818181818182 0.464870931537598 0.888928515838341 0.987580487166462 GO:0019212 phosphatase inhibitor activity 1/729 56/18639 0.0178571428571429 0.456569664902998 0.893285549413128 0.991238196071063 GO:0016887 ATP hydrolysis activity 12/729 417/18639 0.0287769784172662 0.735766942001954 0.894986163682643 0.991942998081596 GO:0015932 nucleobase-containing compound transmembrane transporter activity 1/729 57/18639 0.0175438596491228 0.448559670781893 0.897471893624387 0.993411715414162 GO:0005249 voltage-gated potassium channel activity 2/729 98/18639 0.0204081632653061 0.521793902746284 0.900614411975556 0.993411715414162 GO:0042626 ATPase-coupled transmembrane transporter activity 2/729 98/18639 0.0204081632653061 0.521793902746284 0.900614411975556 0.993411715414162 GO:0008408 3'-5' exonuclease activity 1/729 58/18639 0.0172413793103448 0.440825883354619 0.901494226502862 0.993411715414162 GO:0016757 glycosyltransferase activity 7/729 267/18639 0.0262172284644195 0.670319508022379 0.901646508619729 0.993411715414162 GO:0008168 methyltransferase activity 5/729 204/18639 0.0245098039215686 0.626664245945292 0.904917840218047 0.99489362326906 GO:0099094 ligand-gated monoatomic cation channel activity 3/729 136/18639 0.0220588235294118 0.563997821350763 0.90512878507937 0.99489362326906 GO:0004722 protein serine/threonine phosphatase activity 2/729 103/18639 0.0194174757281553 0.496464101642095 0.915337089996147 0.999975596336519 GO:0004518 nuclease activity 5/729 209/18639 0.0239234449760766 0.611672278338945 0.915428828901613 0.999975596336519 GO:0043021 ribonucleoprotein complex binding 4/729 177/18639 0.0225988700564972 0.577805677617354 0.919308574888336 0.999975596336519 GO:1901682 sulfur compound transmembrane transporter activity 1/729 63/18639 0.0158730158730159 0.405839702135998 0.919361746391721 0.999975596336519 GO:0004536 DNA nuclease activity 1/729 64/18639 0.015625 0.399498456790123 0.92252632901879 0.999975596336519 GO:0000149 SNARE binding 2/729 106/18639 0.0188679245283019 0.482413230840904 0.923161308070103 0.999975596336519 GO:0019843 rRNA binding 1/729 65/18639 0.0153846153846154 0.39335232668566 0.925566883858375 0.999975596336519 GO:0120013 lipid transfer activity 1/729 65/18639 0.0153846153846154 0.39335232668566 0.925566883858375 0.999975596336519 GO:0016741 transferase activity, transferring one-carbon groups 5/729 215/18639 0.0232558139534884 0.594602354292277 0.926682211508365 0.999975596336519 GO:0004843 cysteine-type deubiquitinase activity 2/729 108/18639 0.0185185185185185 0.473479652491998 0.927993499484162 0.999975596336519 GO:0008173 RNA methyltransferase activity 1/729 67/18639 0.0149253731343284 0.381610466187581 0.931295138570765 0.999975596336519 GO:0140223 general transcription initiation factor activity 1/729 68/18639 0.0147058823529412 0.375998547567175 0.933991985651419 0.999975596336519 GO:0015276 ligand-gated monoatomic ion channel activity 4/729 186/18639 0.021505376344086 0.549847338377804 0.936125746925877 0.999975596336519 GO:0022834 ligand-gated channel activity 4/729 188/18639 0.0212765957446809 0.543997898607828 0.939402139974648 0.999975596336519 GO:0061775 cohesin loader activity 3/729 153/18639 0.0196078431372549 0.501331396756233 0.941547034634073 0.999975596336519 GO:0101005 deubiquitinase activity 2/729 115/18639 0.0173913043478261 0.444659151905529 0.942739739008973 0.999975596336519 GO:0003684 damaged DNA binding 1/729 74/18639 0.0135135135135135 0.345512178845512 0.948092297932401 0.999975596336519 GO:0005085 guanyl-nucleotide exchange factor activity 5/729 230/18639 0.0217391304347826 0.555823939881911 0.94920053143339 0.999975596336519 GO:0003725 double-stranded RNA binding 1/729 75/18639 0.0133333333333333 0.340905349794239 0.950130580442893 0.999975596336519 GO:0003697 single-stranded DNA binding 2/729 121/18639 0.0165289256198347 0.422609937761453 0.953049496743894 0.999975596336519 GO:0003724 RNA helicase activity 1/729 77/18639 0.012987012987013 0.332050665383999 0.953970477997936 0.999975596336519 GO:0004674 protein serine/threonine kinase activity 11/729 433/18639 0.0254041570438799 0.649530978245374 0.954404970274903 0.999975596336519 GO:0008186 ATP-dependent activity, acting on RNA 1/729 79/18639 0.0126582278481013 0.32364431942491 0.957515081358845 0.999975596336519 GO:0035591 signaling adaptor activity 2/729 129/18639 0.0155038759689922 0.396401569528185 0.964066651456005 0.999975596336519 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 2/729 130/18639 0.0153846153846154 0.39335232668566 0.965255177628534 0.999975596336519 GO:0015291 secondary active transmembrane transporter activity 6/729 287/18639 0.0209059233449477 0.534520583301071 0.9705238699212 0.999975596336519 GO:0015297 antiporter activity 2/729 135/18639 0.0148148148148148 0.378783721993598 0.970652591883773 0.999975596336519 GO:0005319 lipid transporter activity 3/729 178/18639 0.0168539325842697 0.430919683728672 0.972228024424623 0.999975596336519 GO:0046943 carboxylic acid transmembrane transporter activity 3/729 188/18639 0.0159574468085106 0.407998423955871 0.979562999540538 0.999975596336519 GO:0140597 protein carrier chaperone 3/729 188/18639 0.0159574468085106 0.407998423955871 0.979562999540538 0.999975596336519 GO:0061659 ubiquitin-like protein ligase activity 8/729 372/18639 0.021505376344086 0.549847338377804 0.979573464426859 0.999975596336519 GO:0005342 organic acid transmembrane transporter activity 3/729 189/18639 0.0158730158730159 0.405839702135998 0.980185267794034 0.999975596336519 GO:0008509 monoatomic anion transmembrane transporter activity 2/729 149/18639 0.0134228187919463 0.343193305161985 0.981804821737924 0.999975596336519 GO:0000510 H3-H4 histone complex chaperone activity 2/729 151/18639 0.0132450331125828 0.338647698471098 0.983016000599309 0.999975596336519 GO:0140584 chromatin extrusion motor activity 2/729 151/18639 0.0132450331125828 0.338647698471098 0.983016000599309 0.999975596336519 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 2/729 151/18639 0.0132450331125828 0.338647698471098 0.983016000599309 0.999975596336519 GO:0140849 ATP-dependent H2AZ histone chaperone activity 2/729 151/18639 0.0132450331125828 0.338647698471098 0.983016000599309 0.999975596336519 GO:0015616 DNA translocase activity 2/729 152/18639 0.0131578947368421 0.33641975308642 0.98359186803882 0.999975596336519 GO:0140674 ATP-dependent histone chaperone activity 2/729 152/18639 0.0131578947368421 0.33641975308642 0.98359186803882 0.999975596336519 GO:0061630 ubiquitin protein ligase activity 7/729 353/18639 0.0198300283286119 0.507012205784633 0.986117803985244 0.999975596336519 GO:0140658 ATP-dependent chromatin remodeler activity 2/729 158/18639 0.0126582278481013 0.32364431942491 0.986668871399018 0.999975596336519 GO:0003689 DNA clamp loader activity 2/729 160/18639 0.0125 0.319598765432099 0.98756375205981 0.999975596336519 GO:0035402 histone H3T11 kinase activity 4/729 247/18639 0.0161943319838057 0.414055080721747 0.988384741484374 0.999975596336519 GO:0035403 histone H3T6 kinase activity 4/729 247/18639 0.0161943319838057 0.414055080721747 0.988384741484374 0.999975596336519 GO:0042393 histone binding 4/729 247/18639 0.0161943319838057 0.414055080721747 0.988384741484374 0.999975596336519 GO:0106310 protein serine kinase activity 7/729 361/18639 0.0193905817174515 0.495776478232619 0.988630521303648 0.999975596336519 GO:0140104 molecular carrier activity 4/729 249/18639 0.0160642570281124 0.410729337101492 0.989048697027328 0.999975596336519 GO:0140713 histone chaperone activity 2/729 164/18639 0.0121951219512195 0.311803673592291 0.989181404999024 0.999975596336519 GO:0015103 inorganic anion transmembrane transporter activity 2/729 165/18639 0.0121212121212121 0.309913954358399 0.989552606005628 0.999975596336519 GO:0016874 ligase activity 2/729 167/18639 0.0119760479041916 0.306202409994825 0.990258110838917 0.999975596336519 GO:0015108 chloride transmembrane transporter activity 1/729 121/18639 0.00826446280991736 0.211304968880726 0.992120213842337 0.999975596336519 GO:0004519 endonuclease activity 1/729 127/18639 0.0078740157480315 0.201322056965102 0.99380780328683 0.999975596336519 GO:0016755 aminoacyltransferase activity 10/729 496/18639 0.0201612903225806 0.515481879729191 0.994236328301004 0.999975596336519 GO:0016779 nucleotidyltransferase activity 1/729 136/18639 0.00735294117647059 0.187999273783588 0.995687041360964 0.999975596336519 GO:0019787 ubiquitin-like protein transferase activity 9/729 479/18639 0.0187891440501044 0.480398979355138 0.996344055597018 0.999975596336519 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 3/729 243/18639 0.0123456790123457 0.315653101661332 0.99647775992408 0.999975596336519 GO:0004676 3-phosphoinositide-dependent protein kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:0004711 ribosomal protein S6 kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:0035175 histone H3S10 kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:0035979 histone H2AXS139 kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:0044022 histone H3S28 kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:0044023 histone H4S1 kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:0044024 histone H2AS1 kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:0044025 histone H2BS14 kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:0072354 histone H3T3 kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:0072371 histone H2AS121 kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:0072518 Rho-dependent protein serine/threonine kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:0140823 histone H2BS36 kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:0140855 histone H3S57 kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:0140995 histone H2A kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:0140997 histone H4 kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:0140998 histone H2B kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:1990244 histone H2AT120 kinase activity 3/729 245/18639 0.0122448979591837 0.31307634164777 0.996702246072965 0.999975596336519 GO:0004677 DNA-dependent protein kinase activity 3/729 246/18639 0.0121951219512195 0.311803673592291 0.996809205280781 0.999975596336519 GO:0140857 histone H3T45 kinase activity 3/729 246/18639 0.0121951219512195 0.311803673592291 0.996809205280781 0.999975596336519 GO:0004842 ubiquitin-protein transferase activity 8/729 449/18639 0.0178173719376392 0.455552805961121 0.996928522014087 0.999975596336519 GO:0004679 AMP-activated protein kinase activity 3/729 248/18639 0.0120967741935484 0.309289127837515 0.997013087733064 0.999975596336519 GO:0008094 ATP-dependent activity, acting on DNA 2/729 210/18639 0.00952380952380952 0.243503821281599 0.997887390596899 0.999975596336519 GO:0004386 helicase activity 1/729 155/18639 0.00645161290322581 0.164954201513341 0.997991239892032 0.999975596336519 GO:0003823 antigen binding 1/729 174/18639 0.00574712643678161 0.146941961118206 0.999065170051957 0.999975596336519 GO:0140097 catalytic activity, acting on DNA 4/729 336/18639 0.0119047619047619 0.304379776601999 0.999258944867089 0.999975596336519 GO:0045182 translation regulator activity 3/729 356/18639 0.00842696629213483 0.215459841864336 0.999926486502085 0.999975596336519 GO:0030371 translation repressor activity 2/729 329/18639 0.0060790273556231 0.155427971030808 0.999974106266489 0.999975596336519 GO:0140098 catalytic activity, acting on RNA 3/729 387/18639 0.00775193798449612 0.198200784764092 0.999975596336519 0.999975596336519