category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	92/555	238/9376	6.5303353773942	F13A1/CCL2/C1QA/RPS23/CYBB/C1QB/C1QC/NRP1/RPL10/RPL13A/RPS12/RPS27A/RPS19/RPL28/RPLP1/RPS11/RPL13/RPS18/RPL26/RPL15/UBA52/RPS2/RPL35/RPL32/FCGR2A/RPS15A/RPL23A/RPL29/RPS4X/RPL30/RPL19/CFD/RPL39/RPL23/RPS16/RPS15/RPS14/FAU/RPL18A/RPL11/RPL41/RPS9/RPL12/RPL27A/RPL21/RPS24/RPS25/RPSA/RPL10A/RPS20/RPS6/RPL18/RPL24/RPS13/RPL3/AGTR1/RPL35A/PRKCB/SYK/NFKB1/RPL14/RPL9/JUN/RPL17/RPL6/RPLP0/RPL22/C2/RPL34/C3AR1/RPLP2/RPL36A/RPL7/RPL36/RPS8/RPL8/RPL7A/PRKCA/RPL37/RPS5/NLRP3/RPS7/RPL27/RPS3A/TNF/C1R/RPL31/RPL37A/RPL36AL/TLR4/MMP1/RPL5	21.6764216095708
Genetic Information Processing	Translation	hsa03010	Ribosome	71/555	222/9376	5.40293807320834	RPS23/RPL10/RPL13A/RPS12/RPS27A/RPS19/RPL28/RPLP1/RPS11/RPL13/RPS18/RPL26/RPL15/UBA52/RPS2/RPL35/RPL32/RPS15A/RPL23A/RPL29/RPS4X/RPL30/RPL19/RPL39/RPL23/RPS16/RPS15/RPS14/RACK1/FAU/RPL18A/RPL11/RPL41/RPS9/RPL12/RPL27A/RPL21/RPS24/RPS25/RPSA/RPL10A/RPS20/RPS6/RPL18/RPL24/RPS13/RPL3/RPL35A/RPL14/RPL9/RPL17/RPL6/RPLP0/RPL22/RPL34/RPLP2/RPL36A/RPL7/RPL36/RPS8/RPL8/RPL7A/RPL37/RPS5/RPS7/RPL27/RPS3A/RPL31/RPL37A/RPL36AL/RPL5	16.6527832394645
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	62/555	205/9376	5.10931223906834	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/CYBA/MT-CO1/MT-ND1/CYBB/MT-ND2/CD36/MT-ND4/ATP5F1E/MT-ND5/COL1A2/RYR2/COX6C/PLCB1/COL3A1/UQCRB/COX5B/NDUFA4/CTSD/COX4I1/UQCR10/COX7C/MT-ND3/UQCR11/NDUFB2/COX6B1/AGTR1/COL1A1/PRKCB/NFKB1/COX8A/NDUFC2/NDUFA2/ATP5MC2/UQCRH/ATP5MC3/NDUFA13/COX7A2/UQCRQ/NCF4/COX4I2/PRKCA/SLC25A5/ATP5PF/NDUFB5/NDUFV2/NDUFB11/NDUFB3/COX7B/MMP2/NDUFA1/NDUFS6/PLCB4/ATP5PD/ATP5F1D/RAC2/TBC1D4/NDUFB7/ATP5PO	14.921447120043
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	50/555	138/9376	6.12090351220786	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-CO1/MT-ND1/MT-ND2/MT-ND4/ATP5F1E/MT-ND5/COX6C/UQCRB/COX5B/NDUFA4/COX4I1/UQCR10/COX7C/MT-ND3/UQCR11/NDUFB2/COX6B1/ATP5MG/COX8A/NDUFC2/NDUFA2/ATP5MC2/UQCRH/ATP5MC3/NDUFA13/ATP6V1F/COX7A2/ATP5MF/UQCRQ/COX4I2/ATP6V0B/ATP5PF/NDUFB5/NDUFV2/NDUFB11/NDUFB3/COX7B/NDUFA1/NDUFS6/ATP5ME/ATP5PD/ATP5F1D/ATP6V1A/NDUFB7/ATP6V1G1/ATP5PO	15.2009375893154
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	63/555	275/9376	3.87019164619165	MT-CO2/MT-ATP6/MT-CYB/C1QA/MT-CO3/CYBA/MT-CO1/MT-ND1/CYBB/C1QB/MT-ND2/C1QC/MT-ND4/ATP5F1E/MT-ND5/RYR2/TUBA1B/COX6C/ITPR2/UQCRB/COX5B/NDUFA4/COX4I1/UQCR10/COX7C/MT-ND3/EGR1/UQCR11/PRKACB/NDUFB2/COX6B1/COX8A/NDUFC2/NDUFA2/ATP5MC2/UQCRH/ATP5MC3/NDUFA13/HSPA1A/COX7A2/UQCRQ/NCF4/COX4I2/TUBB/HSPA8/SLC25A5/ATP5PF/PSMA7/NDUFB5/NDUFV2/NDUFB11/NDUFB3/COX7B/NDUFA1/NDUFS6/NCAM2/RYR1/TNF/ATP5PD/ATP5F1D/RAC2/NDUFB7/ATP5PO	12.1173012345094
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	53/555	227/9376	3.94434258046593	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/CYBA/MT-CO1/MT-ND1/MT-ND2/MT-ND4/ATP5F1E/MT-ND5/PLD1/COX6C/HGF/UQCRB/COX5B/NDUFA4/COX4I1/UQCR10/COX7C/MT-ND3/UQCR11/NDUFB2/COX6B1/NFKB1/COX8A/NDUFC2/NDUFA2/ATP5MC2/JUN/UQCRH/PTPRJ/ATP5MC3/NDUFA13/COX7A2/UQCRQ/COX4I2/SLC25A5/ATP5PF/NDUFB5/AHR/NDUFV2/NDUFB11/NDUFB3/COX7B/NDUFA1/NDUFS6/ATP5PD/ATP5F1D/GRB2/HIF1A/NDUFB7/ATP5PO	11.2638711337338
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	57/555	268/9376	3.59306171843485	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-CO1/MT-ND1/MT-ND2/MT-ND4/RPS27A/ATP5F1E/UBA52/MT-ND5/TUBA1B/COX6C/ITPR2/UQCRB/COX5B/NDUFA4/COX4I1/UQCR10/CALM2/GNAI2/COX7C/MT-ND3/CALM3/UQCR11/PRKACB/NDUFB2/UBB/COX6B1/COX8A/NDUFC2/NDUFA2/ATP5MC2/CALM1/UQCRH/ATP5MC3/NDUFA13/COX7A2/UQCRQ/COX4I2/TUBB/SLC25A5/ATP5PF/PSMA7/NDUFB5/NDUFV2/NDUFB11/NDUFB3/COX7B/NDUFA1/NDUFS6/ATP5PD/ATP5F1D/NDUFB7/PRKN/ATP5PO	10.8029398621013
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	49/555	235/9376	3.52251485528081	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-CO1/MT-ND1/MT-ND2/MT-ND4/ATP5F1E/MT-ND5/COX6C/UQCRB/COX5B/NDUFA4/COX4I1/UQCR10/COX7C/MT-ND3/UQCR11/PRKACB/RPS6/NDUFB2/COX6B1/ATP5MG/COX8A/NDUFC2/NDUFA2/ATP5MC2/UQCRH/ATP5MC3/NDUFA13/COX7A2/ATP5MF/UQCRQ/COX4I2/ATP5PF/NDUFB5/NDUFV2/NDUFB11/NDUFB3/COX7B/NDUFA1/NDUFS6/ATP5ME/ATP5PD/ATP5F1D/GRB2/NDUFB7/ATP5PO	9.82299737288021
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	54/555	308/9376	2.96188136188136	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-CO1/MT-ND1/MT-ND2/MT-ND4/ATP5F1E/MT-ND5/TUBA1B/COX6C/PLCB1/UQCRB/COX5B/NDUFA4/CLTA/CLTC/COX4I1/UQCR10/COX7C/MT-ND3/UQCR11/NDUFB2/COX6B1/COX8A/NDUFC2/NDUFA2/ATP5MC2/UQCRH/ATP5MC3/NDUFA13/COX7A2/UQCRQ/AP2S1/COX4I2/TUBB/SLC25A5/ATP5PF/PSMA7/NDUFB5/NDUFV2/NDUFB11/NDUFB3/COX7B/NDUFA1/NDUFS6/POLR2L/AP2M1/PLCB4/ATP5PD/ATP5F1D/NDUFB7/ATP5PO	8.78143644694345
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	60/555	388/9376	2.61242685984954	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-CO1/MT-ND1/CYBB/MT-ND2/WNT2/MT-ND4/ATP5F1E/MT-ND5/TUBA1B/COX6C/PLCB1/ITPR2/UQCRB/COX5B/NDUFA4/COX4I1/UQCR10/CALM2/COX7C/MT-ND3/CALM3/UQCR11/NDUFB2/COX6B1/NFKB1/COX8A/NDUFC2/NDUFA2/ATP5MC2/APOE/CALM1/UQCRH/ATP5MC3/NDUFA13/COX7A2/UQCRQ/COX4I2/TUBB/SLC25A5/ATP5PF/PSMA7/NDUFB5/NDUFV2/NDUFB11/LRP1/NDUFB3/COX7B/NDUFA1/NDUFS6/PLCB4/TNF/ATP5PD/ATP5F1D/ADAM10/NDUFB7/ATP5PO	8.13649896772122
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	67/555	480/9376	2.35807807807808	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-CO1/MT-ND1/CYBB/MT-ND2/WNT2/MT-ND4/RPS27A/ATP5F1E/UBA52/MT-ND5/RYR2/TUBA1B/COX6C/PLCB1/ITPR2/UQCRB/COX5B/NDUFA4/COX4I1/UQCR10/CALM2/COX7C/MT-ND3/CALM3/UQCR11/NDUFB2/UBB/COX6B1/PRKCB/NFKB1/COX8A/NDUFC2/NDUFA2/ATP5MC2/CALM1/UQCRH/ATP5MC3/NDUFA13/COX7A2/UQCRQ/COX4I2/TUBB/PRKCA/SLC25A5/ATP5PF/PSMA7/NDUFB5/NDUFV2/NDUFB11/NDUFB3/COX7B/NDUFA1/NDUFS6/TANK/PLCB4/RYR1/TNF/ATP5PD/ATP5F1D/TNFRSF1B/NDUFB7/PRKN/ATP5PO	7.66163025211905
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	34/555	157/9376	3.65850691455787	MT-CO2/MT-CYB/MT-CO3/MT-CO1/COX6C/UQCRB/COX5B/NDUFA4/COX4I1/UQCR10/COX7C/UQCR11/NDUFB2/COX6B1/NFKB1/COX8A/NDUFC2/NDUFA2/JUN/UQCRH/NDUFA13/COX7A2/UQCRQ/COX4I2/NDUFB5/NDUFV2/NDUFB11/NDUFB3/COX7B/NDUFA1/NDUFS6/TNF/CDC42/NDUFB7	8.42595104731153
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	24/555	87/9376	4.66032929481205	MT-CO2/MT-CYB/MT-CO3/MT-CO1/ATP1B3/RYR2/COX6C/UQCRB/COX5B/COX4I1/UQCR10/COX7C/UQCR11/TPM3/COX6B1/COX8A/UQCRH/ATP1B1/COX7A2/UQCRQ/COX4I2/CACNB4/COX7B/ASPH	8.60336842520128
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	31/555	155/9376	3.37873873873874	CD14/CYBA/CYBB/FCGR3A/CD36/HLA-C/FCGR2A/TUBA1B/MRC1/COLEC12/HLA-DRA/CTSS/FCGR1A/ITGB2/MSR1/CD209/CLEC7A/ATP6V1F/NCF4/ITGAM/TUBB/CORO1A/ATP6V0B/RAB5C/M6PR/C1R/HLA-DPA1/ATP6V1A/TLR4/HLA-DMA/ATP6V1G1	7.4902584306722
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	30/555	149/9376	3.40141483765645	MT-ND1/MT-ND2/GNG2/GNGT1/MT-ND4/MT-ND5/GNG11/GNG10/PLCB1/ITPR2/NDUFA4/GNAI2/MT-ND3/PRKACB/NDUFB2/PRKCB/NDUFC2/NDUFA2/GNG5/NDUFA13/PRKCA/GNB4/NDUFB5/NDUFV2/NDUFB11/NDUFB3/NDUFA1/NDUFS6/PLCB4/NDUFB7	7.41145169365161
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	21/555	78/9376	4.54830214830215	CD14/C1QA/C1QB/C1QC/CFL1/LY96/CALM2/GNAI2/CALM3/ITGB2/NFKB1/JUN/CALM1/C2/PYCARD/ITGAM/NLRP3/TNF/C1R/C4BPB/TLR4	7.89307706883721
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	52/555	368/9376	2.38715236976107	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-CO1/MT-ND1/MT-ND2/MT-ND4/ATP5F1E/MT-ND5/TUBA1B/COX6C/UQCRB/COX5B/NDUFA4/COX4I1/UQCR10/COX7C/MT-ND3/UQCR11/PFN1/NDUFB2/COX6B1/COX8A/NDUFC2/NDUFA2/ATP5MC2/UQCRH/ATP5MC3/NDUFA13/COX7A2/UQCRQ/COX4I2/TUBB/ATP5PF/PSMA7/NDUFB5/NDUFV2/NDUFB11/NDUFB3/COX7B/NDUFA1/NDUFS6/TANK/TNF/ATP5PD/ATP5F1D/CHCHD10/TNFRSF1B/NDUFB7/PRKN/ATP5PO	6.80937273477772
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	33/555	193/9376	2.88855902534659	CXCL14/CCL3/CCL2/CCL4/CCL4L2/GNG2/GNGT1/GNG11/CCL3L1/GNG10/PLCB1/GNAI2/DOCK2/LYN/PRKACB/PRKCB/NFKB1/GNG5/ARRB2/CCL8/ELMO1/GNB4/GRK3/PREX1/PLCB4/CDC42/HCK/GRB2/RAC2/WAS/CCR1/JAK3/VAV1	6.64951766287398
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	22/555	98/9376	3.79246184960471	FCGR3A/MARCKS/FCGR2A/PTPRC/PLD1/CFL1/ARPC3/ARPC1B/LYN/BIN1/PRKCB/FCGR1A/SYK/PRKCA/INPP5D/ARPC5/ACTR2/CDC42/HCK/RAC2/WAS/VAV1	6.97021735379839
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	21/555	95/9376	3.73439544807966	CCL3/CCL2/CCL3L1/HLA-DRA/CD86/TNFSF13B/CD28/ITGB2/JUN/ATP6V1F/ATP6V0B/ICAM1/ANGPT1/TNFRSF11A/TNF/HLA-DPA1/ATP6V1A/TLR4/MMP1/HLA-DMA/ATP6V1G1	6.7189120684743
NA	NA	hsa04517	IgSF CAM signaling	42/555	299/9376	2.37302720780982	NRP1/MTSS1/MAGI1/PTPRD/TUBA1B/CADM3/SLIT3/LMO7/CD86/ROBO2/EPB41L2/ARPC3/ARPC1B/LYN/ROBO1/IL1RAPL1/PRKCB/LCP2/CD28/ITGB2/ANK2/CD209/NRP2/DOK2/ITGAM/TUBB/EPB41L3/PRKCA/KDR/MYL6/INPP5D/UNC5C/ICAM1/ARPC5/NCAM2/ICAM2/DYNLL1/ACTR2/CDC42/GRB2/VAV1/RAPGEF6	6.05224901514907
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	29/555	181/9376	2.70672440396197	CD14/FCER1G/FCGR3A/CD74/CR1/FCGR2A/MRC1/HLA-DRA/CTSD/CALM2/CTSS/CALM3/FCGR1A/ITGB2/SYK/NFKB1/CD209/CLEC7A/CALM1/TLR1/ITGAM/CORO1A/ATP6V0B/RAB5C/TNF/LSP1/HLA-DPA1/TLR4/HLA-DMA	5.81567378274823
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	32/555	216/9376	2.50276943610277	CD14/CCL3/CCL2/CYBA/CYBB/CD36/VCAM1/CCL3L1/PLCB1/LY96/CALM2/LYN/CALM3/NFKB1/JUN/CALM1/HSPA1A/PYCARD/NCF4/HSPA8/PRKCA/NLRP3/ICAM1/TANK/PLCB4/TNF/CDC42/POU2F2/TLR4/MMP1/VAV1/TNFRSF10B	5.60460114384287
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	24/555	140/9376	2.89606177606178	SPP1/MEF2C/GNG2/GNGT1/GNG11/RYR2/GNG10/PLCB1/ITPR2/CALM2/GNAI2/EGR1/CALM3/PRKACB/RPS6/AGTR1/MEF2A/GNG5/CALM1/CCND1/KLF2/GNB4/PLCB4/RYR1	5.66953913620568
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	17/555	78/9376	3.68195888195888	CYBA/CYBB/FCGR3A/CR1/FCGR2A/HLA-DRA/PRKCB/FCGR1A/ITGB2/NFKB1/JUN/NCF4/ITGAM/TNF/HLA-DPA1/TLR4/HLA-DMA	5.96592603053356
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	19/555	97/9376	3.30907402247608	GNG2/GNGT1/GUCY1A2/GNG11/RYR2/GNG10/PLCB1/CALM2/GNAI2/CALM3/PRKACB/PRKCB/GNG5/CALM1/GUCY1A1/PRKCA/GNB4/PLCB4/RYR1	5.73385034957319
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	32/555	227/9376	2.38148985990396	CCL3/CCL2/CCL4/CCL4L2/GNG2/GNGT1/B2M/HLA-C/GNG11/CCL3L1/CDK6/GNG10/PLCB1/ITPR2/CALM2/GNAI2/CALM3/PRKACB/PRKCB/NFKB1/GNG5/CALM1/RB1/CCND1/PRKCA/GNB4/PTGER4/PLCB4/TNF/GRB2/RAC2/CCR1	5.28502486692823
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	13/555	50/9376	4.39236036036036	CCL2/CD36/VCAM1/CR1/PECAM1/HGF/CD81/ITGB2/HBA2/ICAM1/LRP1/TNF/TLR4	6.03271064516484
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/555	101/9376	3.17802158594238	CCL2/CYBB/VCAM1/COL1A2/PLCB1/COL3A1/EGR1/AGTR1/COL1A1/PRKCB/NFKB1/JUN/CCND1/PRKCA/ICAM1/MMP2/PLCB4/TNF/CDC42	5.52000061503625
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	19/555	103/9376	3.11631242893379	CD14/LAMA2/COL1A2/PLCB1/COL3A1/PRKACB/COL1A1/PRKCB/ITGB2/NFKB1/GNA14/SERPINB9/ITGAM/LAMA4/PRKCA/RAB5C/PLCB4/TNF/TLR4	5.41703303038655
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	13/555	53/9376	4.14373618901921	ATP1B3/PLCB1/ATP2B1/CLTA/CLTC/PRKACB/PRKCB/ATP1B1/AP2S1/PRKCA/AP2M1/PLCB4/RAB11A	5.75677699137203
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	28/555	196/9376	2.41338481338481	GNG2/GNGT1/RPS27A/UBA52/HLA-C/GNG11/CDK6/GNG10/CD86/ITPR2/CALM2/LYN/CALM3/UBB/SYK/NFKB1/GNG5/CD200R1/JUN/CALM1/RB1/CCND1/GNB4/ICAM1/PREX1/HCK/CCR1/HIF1A	5.01580142358884
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	20/555	116/9376	2.91270580925753	CYBA/CYBB/VCAM1/PECAM1/GNAI2/PRKCB/ITGB2/NCF4/ITGAM/PRKCA/ICAM1/MMP2/THY1/TXK/CDC42/RAC2/CDH5/VAV1/CD99/CLDN5	5.19930023847791
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	29/555	212/9376	2.31092979772225	FYB1/MAGI1/DOCK4/IGF1/HGF/PLCB1/CALM2/GNAI2/CALM3/PFN1/PDGFC/PRKCB/LCP2/ITGB2/KITLG/CALM1/CSF1R/ITGAM/PRKCA/KDR/MAGI3/ANGPT1/PLCB4/CDC42/EVL/RAC2/SIPA1L2/VAV1/RAPGEF6	4.84259382731519
Organismal Systems	Digestive system	hsa04970	Salivary secretion	17/555	93/9376	3.08809454615906	CST3/GUCY1A2/ATP1B3/PLCB1/ITPR2/ATP2B1/CALM2/CALM3/PRKACB/PRKCB/CALM1/LYZ/ATP1B1/GUCY1A1/PRKCA/PLCB4/ADRB1	5.07598905316315
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	32/555	250/9376	2.16239279279279	DAB2/WWP1/FOLR2/HLA-C/PLD1/PSD3/SNX2/ARPC3/CLTA/CLTC/SNX6/ARPC1B/BIN1/ARAP1/HSPA1A/ARRB2/CYTH4/AP2S1/CAPZA2/HSPA8/EPS15/RAB5C/GRK3/ARPC5/MVB12B/AP2M1/SNX3/ACTR2/CDC42/VPS45/RAB11A/CAPZB	4.672570893933
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	10/555	37/9376	4.56586316045775	VCAM1/PLCB1/PRKCB/IDO2/HBA2/LAMA4/PRKCA/ICAM1/PLCB4/TNF	5.4511554410436
Organismal Systems	Endocrine system	hsa04924	Renin secretion	14/555	69/9376	3.4277059668364	GUCY1A2/PLCB1/ITPR2/CALM2/GNAI2/CALM3/PRKACB/AGTR1/CTSB/CALM1/GUCY1A1/PTGER4/PLCB4/ADRB1	5.07678758679537
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	16/555	88/9376	3.07158067158067	F13A1/C1QA/C1QB/C1QC/CR1/A2M/CFD/ITGB2/C2/VSIG4/C3AR1/ITGAM/PROS1/C1R/C4BPB/PLAUR	4.89728413134207
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	23/555	160/9376	2.42846846846847	VCAM1/HLA-C/PTPRD/CADM3/PTPRC/PECAM1/HLA-DRA/CD86/VCAN/CD28/ITGB2/CD4/ALCAM/ITGAM/ICAM1/NCAM2/ICAM2/SIGLEC1/HLA-DPA1/CDH5/CD99/CLDN5/HLA-DMA	4.57122539119948
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	31/555	250/9376	2.09481801801802	LGMN/CTSC/LAPTM5/CTSZ/NPC2/CLTA/CLTC/CTSD/ASAH1/CD68/CTSS/AP1S2/CTSB/MANBA/CD63/ATP6V1F/SUMF1/AP2S1/LAMTOR4/AP1B1/ATP6V0B/BLOC1S1/M6PR/LAMTOR2/VAMP8/AP2M1/ATP6V1A/WDR7/MAN2B1/ATP6V1G1/LAMTOR1	4.40093472435725
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	20/555	130/9376	2.5990297990298	GNG2/GNGT1/COL1A2/GNG11/GNG10/PLCB1/COL3A1/GNAI2/PRKACB/COL1A1/NFKB1/GNG5/JUN/ARRB2/PRKCA/GNB4/MMP2/PLCB4/GRB2/MMP1	4.60494563658695
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	16/555	93/9376	2.90644192579676	PLD1/PLCB1/ITPR2/CALM2/EGR1/CALM3/PRKACB/PRKCB/JUN/CALM1/CGA/PRKCA/MMP2/PLCB4/CDC42/GRB2	4.63440621672813
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	14/555	76/9376	3.11199620673305	ATP1B3/PLCB1/ITPR2/CALM2/GNAI2/CALM3/PRKACB/PRKCB/CALM1/ATP1B1/PRKCA/HRH2/PLCB4/KCNQ1	4.63694211490173
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	27/555	214/9376	2.13144733518565	GNG2/GNGT1/B2M/HLA-C/GNG11/GNG10/ITPR2/CFL1/CALM2/GNAI2/CALM3/BST2/AP1S2/PRKCB/NFKB1/GNG5/JUN/CALM1/CD4/ELOB/AP1B1/PRKCA/GNB4/TNF/RAC2/TLR4/TNFRSF1B	4.19971003118949
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	20/555	138/9376	2.44836140488314	CCL2/FCGR2A/FYB1/ARPC3/ARPC1B/LCP2/NFKB1/JUN/CD4/PYCARD/ELMO1/NLRP3/ARPC5/TNF/ACTR2/CDC42/RAC2/TLR4/WAS/VAV1	4.29932945815444
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	13/555	70/9376	3.13740025740026	LAMA2/HLA-C/EIF4G3/HLA-DRA/CD86/CD28/ITGB2/DTNA/CCND1/ICAM1/HLA-DPA1/RAC2/HLA-DMA	4.50221853930113
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	16/555	99/9376	2.73029393029393	C1QA/FCGR3A/C1QB/C1QC/FCGR2A/CFD/HLA-DRA/FCGR1A/ITGB2/C2/C3AR1/ITGAM/ICAM1/C1R/HLA-DPA1/HLA-DMA	4.34117128868347
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	20/555	142/9376	2.37939347798503	CCL2/MEF2C/CYBA/VCAM1/PECAM1/CALM2/CALM3/NFKB1/MEF2A/JUN/CALM1/KLF2/KDR/ICAM1/MMP2/BMP4/TNF/SUMO2/RAC2/CDH5	4.15442213982325
NA	NA	hsa04518	Integrin signaling	21/555	154/9376	2.3036855036855	SPP1/LAMA2/VCAM1/COL1A2/IGF1/HGF/CCND2/FREM1/COL6A1/COL1A1/PDGFC/ITGB2/CCND1/ITGAM/LAMA4/KDR/ICAM1/ICAM2/CDC42/RAC2/FERMT3	4.09160646942601
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	11/555	56/9376	3.31840411840412	CD14/CR1/ITGB2/NFKB1/HSPA1A/PYCARD/ITGAM/HSPA8/TNF/TLR4/EEF1G	4.36463987128378
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	28/555	238/9376	1.98749337572867	GNG2/GNGT1/GNG11/PLD1/IGF1/GNG10/HGF/RGL1/CALM2/CALM3/PRKACB/PDGFC/PRKCB/NFKB1/GNG5/KITLG/CALM1/CSF1R/REL/PRKCA/KDR/GNB4/RAB5C/RALGAPA2/ANGPT1/CDC42/GRB2/RAC2	3.87052887180213
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	25/555	204/9376	2.07030559971736	LUM/WNT2/COL1A2/DCN/IGF1/HGF/ITPR2/PRKACB/RPS6/COL1A1/PRKCB/ANK2/TWIST1/CD63/CCND1/PRKCA/KDR/MMP2/TNF/CDC42/GRB2/TLR4/VAV1/HIF1A/PLAUR	3.87671680641057
Organismal Systems	Immune system	hsa04611	Platelet activation	18/555	126/9376	2.41338481338481	FCER1G/GUCY1A2/FCGR2A/COL1A2/PLCB1/COL3A1/ITPR2/GNAI2/LYN/TBXAS1/PRKACB/COL1A1/LCP2/SYK/GUCY1A1/VAMP8/PLCB4/FERMT3	4.00634223565718
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	24/555	195/9376	2.07922383922384	CYBA/CYBB/FCGR3A/HDAC9/CR1/FCGR2A/PLCB1/ATG7/PRKCB/FCGR1A/ITGB2/SYK/NFKB1/CLEC7A/NCF4/ITGAM/HDAC8/PRKCA/SLC25A5/HMGB1/CLCN5/PLCB4/RAC2/TLR4	3.81994456700806
Organismal Systems	Nervous system	hsa04730	Long-term depression	11/555	60/9376	3.09717717717718	GUCY1A2/IGF1/PLCB1/ITPR2/GNAI2/LYN/PRKCB/GUCY1A1/PRKCA/PLCB4/RYR1	4.08760787130387
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	14/555	89/9376	2.65743496305294	GUCY1A2/TUBA1B/PLCB1/ITPR2/GNAI2/PRKACB/PDGFC/PRKCB/GUCY1A1/TUBB/PRKCA/PLCB4/GRB2/ADRB1	3.94064212126863
Human Diseases	Substance dependence	hsa05032	Morphine addiction	14/555	91/9376	2.5990297990298	GNG2/GNGT1/PDE4D/GNG11/GNG10/GNAI2/PRKACB/PRKCB/GNG5/ARRB2/PDE4B/PRKCA/GNB4/GRK3	3.84467397623988
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	13/555	82/9376	2.67826851241485	LGMN/B2M/CD74/HLA-C/HLA-DRA/CTSS/CTSB/CD4/HSPA1A/HSPA8/TNF/HLA-DPA1/HLA-DMA	3.82860231214365
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	16/555	115/9376	2.35042694868782	MEF2C/PDE4D/PLD1/NR4A2/PLCB1/ITPR2/NACA/GNAI2/EGR1/PRKACB/PRKCB/MEF2A/ARRB2/PDE4B/PRKCA/PLCB4	3.65480569365582
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	15/555	105/9376	2.41338481338481	CD14/CCL4/CCL4L2/VCAM1/EDA/LY96/LYN/TNFSF13B/PRKCB/SYK/NFKB1/ICAM1/TNFRSF11A/TNF/TLR4	3.6531289151922
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	18/555	142/9376	2.14145413018652	CYBA/TYROBP/FCGR3A/FCGR2A/ITPR2/FCGR1A/LCP2/SYK/NFKB1/JUN/LILRB5/CSF1R/NCF4/SPI1/TNFRSF11A/JUNB/TNF/GRB2	3.43780247313237
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	14/555	98/9376	2.41338481338481	ATP1B3/NR4A2/PLCB1/ITPR2/ATP2B1/CALM2/CALM3/PRKACB/AGTR1/PRKCB/CALM1/ATP1B1/PRKCA/PLCB4	3.52792621150563
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	19/555	154/9376	2.08428688428688	ATP1B3/RYR2/CREM/PLCB1/ATP2B1/CALM2/GNAI2/CALM3/PRKACB/TPM3/AGTR1/CALM1/ATP1B1/SCN1B/PRKCA/CACNB4/PLCB4/KCNQ1/ADRB1	3.40302566678859
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	19/555	154/9376	2.08428688428688	MEF2C/GUCY1A2/RYR2/PLCB1/ITPR2/CALM2/GNAI2/CALM3/PRKACB/PRKCB/JUN/CALM1/GUCY1A1/CCND1/PRKCA/CACNB4/MYL6/PLCB4/RYR1	3.40302566678859
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	11/555	68/9376	2.73280339162692	CD14/RUNX1/DUSP6/RUNX1T1/FCGR1A/NFKB1/CSF1R/CCND1/ITGAM/SPI1/GRB2	3.59706906989519
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	17/555	133/9376	2.15934430671273	HCST/TYROBP/FCER1G/FCGR3A/HLA-C/PRKCB/LCP2/ITGB2/SYK/PRKCA/ICAM1/ICAM2/TNF/GRB2/RAC2/VAV1/TNFRSF10B	3.3775749602502
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	17/555	133/9376	2.15934430671273	GNG2/GNGT1/GNG11/GNG10/PLCB1/ITPR2/CALM2/GNAI2/CALM3/PRKACB/PRKCB/GNG5/CALM1/ARRB2/PRKCA/GNB4/PLCB4	3.3775749602502
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	11/555	69/9376	2.69319754537146	FCER1G/LYN/LCP2/SYK/PRKCA/INPP5D/TNF/GRB2/RAC2/ALOX5AP/VAV1	3.54079299460464
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	35/555	362/9376	1.63336817480464	SPP1/LAMA2/GNG2/GNGT1/AREG/CSH1/COL1A2/GNG11/MAGI1/CDK6/IGF1/GNG10/HGF/CCND2/COL6A1/RPS6/COL1A1/PDGFC/SYK/NFKB1/YWHAB/LPAR6/GNG5/KITLG/CSF1R/CCND1/LAMA4/PRKCA/PIK3AP1/KDR/GNB4/ANGPT1/GRB2/TLR4/JAK3	3.0826552963622
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/555	42/9376	3.21784641784642	FTL/CYBB/SLC40A1/GPX4/ATG7/FTH1/NCOA4/SAT2	3.61322855976812
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	14/555	103/9376	2.29623021079332	CCL3/CCL2/C1QA/C1QB/C1QC/CCL3L1/PLCB1/GNAI2/NFKB1/JUN/GNA14/PLCB4/TNF/TLR4	3.31790418600429
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	26/555	248/9376	1.7711130485324	CD14/TUBA1B/PTPRC/S100A10/ARPC3/LY96/ARPC1B/PFN1/NFKB1/JUN/PYCARD/CYTH4/TUBB/ELMO1/NCKAP1L/RAB5C/NLRP3/ARPC5/M6PR/DYNLL1/TNF/ACTR2/CDC42/TLR4/BRK1/TNFRSF10B	3.0869478707033
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	15/555	116/9376	2.18452935694315	GNG2/GNGT1/GNG11/PLD1/GNG10/PLCB1/ITPR2/GNAI2/PRKACB/PRKCB/GNG5/PRKCA/GNB4/GRK3/PLCB4	3.21990121963883
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	14/555	105/9376	2.25249249249249	FCER1G/ITPR2/CALM2/CALM3/SYK/NFKB1/CD209/JUN/CLEC7A/CALM1/PYCARD/NLRP3/TNF/LSP1	3.23727586221045
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	8/555	44/9376	3.07158067158067	HLA-C/HLA-DRA/CD86/CD28/ICA1/TNF/HLA-DPA1/HLA-DMA	3.45472945012099
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	13/555	99/9376	2.21836381836382	IGF1/PLCB1/ITPR2/CALM2/CALM3/PRKACB/PRKCB/CALM1/PRKCA/PTGER4/PLCB4/HRH1/PRKCH	3.05677892920383
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/555	89/9376	2.27780139690252	GNG2/GNGT1/GNG11/GNG10/GNAI2/PRKACB/PRKCB/GNG5/PRKCA/GABARAP/GNB4/GABARAPL2	3.03804258960183
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/555	91/9376	2.22773982773983	CD81/LYN/PRKCB/SYK/NFKB1/JUN/LILRB5/PIK3AP1/INPP5D/GRB2/RAC2/VAV1	2.95195209505698
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/555	39/9376	3.03220143220143	HLA-C/HLA-DRA/CD86/CD28/TNF/HLA-DPA1/HLA-DMA	3.18983776874125
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	21/555	200/9376	1.77383783783784	FCGR2A/TUBA1B/ARPC3/ARPC1B/NFKB1/JUN/PYCARD/CYTH4/TUBB/NCKAP1L/NLRP3/MYO5A/ARPC5/MYO1B/TNF/ACTR2/CDC42/TLR4/BRK1/TNFRSF10B/CLDN5	2.77467087442072
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	13/555	103/9376	2.13221376716522	COL15A1/COL14A1/COL1A2/ATP1B3/COL3A1/COL6A1/SLC16A10/COL1A1/ELN/COL21A1/ATP1B1/COL5A2/KCNQ1	2.89807841712783
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	14/555	115/9376	2.05662358010184	GNG2/GNGT1/GNG11/GNG10/PLCB1/ITPR2/GNAI2/PRKACB/PRKCB/GNG5/PRKCA/GNB4/PLCB4/KCNQ1	2.85965403782825
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	21/555	201/9376	1.765012773968	CD14/MEF2C/RUNX1/NR4A3/BMP2K/IGF1/DUSP6/CD86/CCND2/RUNX1T1/FCGR1A/NFKB1/CSF1R/FLI1/ITGAM/SPI1/REL/NFKBIZ/MAF/CDKN2C/LMO2	2.7500266208306
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/555	73/9376	2.31420461557448	CDK6/HGF/PRKCB/FHIT/RARB/RB1/CCND1/PRKCA/GRB2/JAK3	2.82739266137102
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	13/555	109/9376	2.01484420200017	SPP1/CD14/CCL3/CCL4/CCL4L2/CCL3L1/CD86/LY96/NFKB1/JUN/TLR1/TNF/TLR4	2.6731064943701
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	15/555	134/9376	1.89108511496571	GUCY1A2/PLCB1/ITPR2/CALM2/CALM3/PRKACB/AGTR1/PRKCB/CALM1/GUCY1A1/PRKCA/MYL6/PPP1R14A/PLCB4/PRKCH	2.60592447558102
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	22/555	224/9376	1.65920205920206	NRP1/B2M/HLA-C/HLA-DRA/CCND2/EGR1/PRKACB/ITGB2/NFKB1/JUN/CD4/RB1/CCND1/SPI1/SLC25A5/ICAM1/TNF/RANBP1/HLA-DPA1/CDKN2C/JAK3/HLA-DMA	2.5047118905723
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/555	76/9376	2.22285443338075	CDK6/IGF1/CALM2/CALM3/PRKCB/CALM1/RB1/CCND1/PRKCA/GRB2	2.68480843121808
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/555	65/9376	2.33912681912682	SPP1/KISS1/PLCB1/ITPR2/PRKCB/ARRB2/CGA/PRKCA/PLCB4	2.71739918995036
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/555	100/9376	2.02724324324324	CXCL14/CCL3/CCL2/CCL4/CCL4L2/CCL3L1/CSF1R/CCL8/TNF/CCR1/TNFRSF1B/TNFRSF10B	2.59039588843914
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	12/555	100/9376	2.02724324324324	CD14/CD36/CR1/HLA-DRA/FCGR1A/KITLG/CD4/CSF1R/ITGAM/TNF/HLA-DPA1/HLA-DMA	2.59039588843914
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	19/555	187/9376	1.71647155176567	CCL2/CYBA/CYBB/IFI16/PLCB1/ITPR2/NAMPT/NFKB1/CTSB/JUN/PYCARD/GABARAP/NLRP3/TANK/PLCB4/TNF/GABARAPL2/TLR4/GPSM3	2.48232617760365
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	9/555	66/9376	2.3036855036855	IL12RB2/HLA-DRA/NFKB1/JUN/MAF/TNF/HLA-DPA1/TLR4/HLA-DMA	2.66589587352633
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	7/555	45/9376	2.62790790790791	HLA-C/HLA-DRA/CD86/CD28/TNF/HLA-DPA1/HLA-DMA	2.74565024487381
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	9/555	67/9376	2.26930213795885	PLCB1/ITPR2/CALM2/CALM3/PRKACB/PRKCB/CALM1/PRKCA/PLCB4	2.61531567322977
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	18/555	178/9376	1.70835104767689	WNT2/PRICKLE1/PLCB1/CCND2/SERPINF1/PRKACB/PRKCB/RSPO3/RSPO2/JUN/CCND1/PRKCA/NLK/FRZB/PLCB4/TLE4/INVS/RAC2	2.39323341434557
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	13/555	115/9376	1.90972189580885	GNG2/GNGT1/GNG11/GNG10/PLCB1/ITPR2/GNAI2/PRKACB/PRKCB/GNG5/PRKCA/GNB4/PLCB4	2.46207820991447
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	17/555	166/9376	1.73007706501682	MEF2C/GUCY1A2/ATP1B3/PLCB1/ITPR2/ATP2B1/CALM2/GNAI2/CALM3/AGTR1/MEF2A/CALM1/ATP1B1/GUCY1A1/SLC25A5/PLCB4/ADRB1	2.38048885849773
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	27/555	300/9376	1.52043243243243	CD14/MEF2C/AREG/IGF1/DUSP6/HGF/MKNK1/PRKACB/PDGFC/PRKCB/NFKB1/KITLG/JUN/CSF1R/HSPA1A/STMN1/ARRB2/HSPA8/PRKCA/KDR/CACNB4/ANGPT1/NLK/TNF/CDC42/GRB2/RAC2	2.2980049279545
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	15/555	143/9376	1.77206577206577	C1QA/FCGR3A/C1QB/C1QC/FCGR2A/HLA-DRA/CD86/FCGR1A/CD28/C2/TNF/C1R/HLA-DPA1/SNRPD1/HLA-DMA	2.33358765698138
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/555	38/9376	2.6674253200569	ATP1B3/IGF1/PRKCB/ATP1B1/PRKCA/NR3C2	2.58335728429084
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/555	71/9376	2.14145413018652	LYN/NFKB1/JUN/ATP6V1F/ATP6V0B/CDC42/ADAM10/ATP6V1A/ATP6V1G1	2.42160145125445
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	12/555	110/9376	1.8429484029484	CYBB/IGF1/MKNK1/LDHB/RPS6/PRKCB/NFKB1/ELOB/PRKCA/ANGPT1/TLR4/HIF1A	2.23061390710356
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/555	51/9376	2.31874227168345	PRKACB/ATP6V1F/PRKCA/ATP6V0B/ATP6V1A/KCNQ1/ATP6V1G1	2.36861139383255
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	19/555	203/9376	1.58118315359695	SPP1/LAMA2/COL1A2/IGF1/HGF/CCND2/COL6A1/COL1A1/PDGFC/PRKCB/JUN/CCND1/LAMA4/PRKCA/KDR/CDC42/GRB2/RAC2/VAV1	2.09980303016478
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/555	75/9376	2.02724324324324	ATP1B3/PLCB1/ITPR2/PRKACB/PRKCB/ATP1B1/CGA/PRKCA/PLCB4	2.24033168720587
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	12/555	112/9376	1.81003861003861	LAMA2/HLA-DRA/LY96/GNAI2/NFKB1/HSPA1A/LAMA4/HSPA8/TNF/HLA-DPA1/TLR4/HLA-DMA	2.16316016460712
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	13/555	125/9376	1.75694414414414	FCER1G/PLD1/PLCB1/CTSD/GNAI2/ASAH1/PRKCB/NFKB1/PRKCA/PLCB4/TNF/SGMS1/RAC2	2.13696652098954
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	19/555	205/9376	1.56575697648868	HDAC9/HLA-C/RBPJ/CDK6/CCND2/LYN/PRKACB/SYK/NFKB1/YWHAB/JUN/RB1/CCND1/REL/HDAC8/RANBP1/CDC42/GRB2/JAK3	2.05433715335908
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	14/555	139/9376	1.70152310583965	PLCB1/ITPR2/CTSD/CALM2/GNAI2/CALM3/PRKACB/JUN/CALM1/HSPA1A/HSPA8/MMP2/PLCB4/GRB2	2.09005217067696
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	11/555	101/9376	1.83990723396664	WNT2/PLCB1/CALM2/GNAI2/CALM3/PRKACB/PRKCB/KITLG/CALM1/PRKCA/PLCB4	2.12866965047237
Human Diseases	Immune disease	hsa05310	Asthma	5/555	32/9376	2.63963963963964	FCER1G/HLA-DRA/TNF/HLA-DPA1/HLA-DMA	2.33039855429107
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	11/555	102/9376	1.82186892775128	ATP1B3/RYR2/PLCB1/ITPR2/ATP2B1/PRKCB/ATP1B1/PRKCA/PLCB4/KCNQ1/RAB11A	2.09335228245425
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/555	54/9376	2.18992325658992	HLA-C/HLA-DRA/CD86/CD28/CGA/HLA-DPA1/HLA-DMA	2.19955335931978
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/555	79/9376	1.92459801573726	SYT1/CLTA/CLTC/ATP6V1F/AP2S1/ATP6V0B/AP2M1/ATP6V1A/ATP6V1G1	2.06999027906308
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	22/555	253/9376	1.46901684292989	CD14/RPS27A/UBA52/PLCB1/ITPR2/ARPC3/ARPC1B/PFN1/UBB/NFKB1/JUN/PYCARD/CYTH4/ELMO1/NLRP3/ARPC5/SEPTIN7/PLCB4/TNF/ACTR2/CDC42/TLR4	1.89693775694371
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	15/555	157/9376	1.6140471681873	C1QA/C1QB/C1QC/CD36/PECAM1/ELMO1/GAS6/STAB1/ADAM9/RAB5C/PROS1/LRP1/PTGER4/ADAM10/HIF1A	1.94617939549233
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	9/555	80/9376	1.90054054054054	IGF1/HGF/RPS6/PDGFC/PRKCB/PRKCA/KDR/GAS6/GRB2	2.02895971108464
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	22/555	254/9376	1.46323331205221	RYR2/HGF/PLCB1/ITPR2/ATP2B1/CALM2/CALM3/PRKACB/AGTR1/PDGFC/PRKCB/GNA14/CALM1/PRKCA/KDR/SLC25A5/HRH2/PLCB4/RYR1/HRH1/ASPH/ADRB1	1.87734817981496
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	10/555	93/9376	1.81652620362298	RBPJ/IL12RB2/HLA-DRA/NFKB1/JUN/CD4/MAF/HLA-DPA1/JAK3/HLA-DMA	1.98490919811798
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	16/555	173/9376	1.56242253814508	CCL2/CDK6/HLA-DRA/PRKCB/NFKB1/PYCARD/PRKCA/SLC25A5/NLRP3/ICAM1/TNF/HLA-DPA1/TLR4/TNFRSF10B/HLA-DMA/RAB11A	1.8728123960055
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	12/555	122/9376	1.66167478954364	ATP1B3/PLCB1/PRKACB/SLC16A10/PRKCB/ATP1B1/CCND1/PRKCA/BMP4/PLCB4/TBC1D4/HIF1A	1.84515550977299
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	18/555	205/9376	1.48334871456823	B2M/HLA-C/RBPJ/CDK6/HLA-DRA/CCND2/VIM/LYN/SYK/NFKB1/JUN/RB1/CCND1/ICAM1/TNF/HLA-DPA1/JAK3/HLA-DMA	1.75510203785481
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/555	61/9376	1.93862058780092	FTL/SLC40A1/ATP1B3/ATP2B1/FTH1/ATOX1/ATP1B1	1.84474687130228
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/555	50/9376	2.02724324324324	HLA-DRA/CD86/TNFSF13B/CD28/HLA-DPA1/HLA-DMA	1.82676973858664
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	15/555	170/9376	1.4906200317965	RUNX1/MAGI1/TUBA1B/ARPC3/ARPC1B/PRKACB/JUN/CCND1/MYL6/ARPC5/ACTR2/CDC42/WAS/RAPGEF6/CLDN5	1.61922600636996
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/555	52/9376	1.94927234927235	PLTP/CD36/NPC2/APOE/LRP1/APOC1	1.72172818457276
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/555	78/9376	1.73268653268653	ARPC3/CLTA/CLTC/ARPC1B/ELMO1/ARPC5/ACTR2/CDC42	1.62983619435034
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/555	29/9376	2.33016464740603	GNGT1/CALM2/CALM3/CALM1	1.7994571006868
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	10/555	105/9376	1.60892320892321	RPS27A/UBA52/UBB/JUN/TOMM7/GABARAP/RAB5C/GABARAPL2/HIF1A/PRKN	1.57386365028344
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	19/555	233/9376	1.3775973398291	LAMA2/COL1A2/ATP1B3/DCN/COL3A1/VIM/VCAN/COL6A1/TPM3/COL1A1/ANK2/ELN/ATP1B1/DTNA/CAPZA2/TNNT3/NEBL/COL5A2/CAPZB	1.46398202825848
NA	NA	hsa04081	Hormone signaling	18/555	219/9376	1.38852276934469	GNG2/GNGT1/CSH1/SLC40A1/GNG11/IGF1/GNG10/PLCB1/GNAI2/PRKACB/SLC16A10/AGTR1/GNG5/GNA14/CGA/GNB4/PLCB4/ADRB1	1.45926828798392
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	9/555	93/9376	1.63487358326068	LAMA2/CDK6/NFKB1/FHIT/RARB/RB1/CCND1/LAMA4/CKS1B	1.54332636168295
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	11/555	122/9376	1.52320189041501	CSH1/IGF1/PLCB1/ITPR2/GNAI2/PRKACB/PRKCB/PRKCA/JUNB/PLCB4/GRB2	1.45900805966738
Human Diseases	Infectious disease: viral	hsa05162	Measles	12/555	136/9376	1.4906200317965	CDK6/RACK1/CCND2/CD28/NFKB1/CD209/JUN/HSPA1A/CCND1/HSPA8/TLR4/JAK3	1.44561272877515
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/555	109/9376	1.54988015538474	RUNX1/HLA-DRA/NFKB1/JUN/CD4/AHR/HLA-DPA1/JAK3/HIF1A/HLA-DMA	1.44838804969983
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/555	56/9376	1.81003861003861	DISP1/CCND2/PRKACB/CCND1/ARRB2/GRK3	1.52498297712113
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/555	69/9376	1.7138529834182	CALM2/CALM3/PRKACB/PRKCB/JUN/CALM1/PRKCA	1.492800205017
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/555	44/9376	1.91973791973792	PRKACB/RAB5C/DYNLL1/ARHGDIB/RAB11A	1.53382666738589
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	18/555	226/9376	1.34551542693136	PDE4D/ATP1B3/RYR2/PLD1/ATP2B1/CALM2/GNAI2/CALM3/PRKACB/NFKB1/JUN/CALM1/ATP1B1/PDE4B/CGA/RAC2/VAV1/ADRB1	1.31881638514893
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	9/555	98/9376	1.55146166574738	PLCB1/ITPR2/CALM2/CALM3/PRKCB/CALM1/PRKCA/INPP5D/PLCB4	1.37649424757265
NA	NA	hsa04082	Neuroactive ligand signaling	16/555	199/9376	1.35828693014623	GNG2/GNGT1/GNG11/GNG10/PLCB1/GNAI2/PRKACB/PRKCB/GNG5/TAC3/PRKCA/GNB4/HRH2/PLCB4/HRH1/ADRB1	1.28138712795671
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	9/555	99/9376	1.53579033579034	PLD1/PDGFC/PRKCB/JUN/PRKCA/GRB2/RAC2/WAS/HIF1A	1.34425578323098
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/555	86/9376	1.57150639011104	ATP1B3/RYR2/PLCB1/PRKACB/PRKCB/ATP1B1/PRKCA/PLCB4	1.3354747403314
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/555	158/9376	1.38998745581024	WNT2/IGF1/RPS6/PRKCB/ATP6V1F/LAMTOR4/PRKCA/LAMTOR2/TNF/GRB2/ATP6V1A/ATP6V1G1/LAMTOR1	1.24003529952612
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/555	48/9376	1.75975975975976	ATP1B3/PLCB1/PRKCB/ATP1B1/PLCB4	1.32365820593288
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	8/555	89/9376	1.51853426460168	SPP1/LAMA2/CD36/COL1A2/FREM1/COL6A1/COL1A1/LAMA4	1.23284352626823
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/555	12/9376	2.81561561561562	CD209/NCAM2	1.57854529665568
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/555	76/9376	1.55599810336652	PLTP/CD36/FABP5/DBI/ME1/SLC27A4/MMP1	1.22070816845534
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/555	105/9376	1.44803088803089	LAMA2/RYR2/IGF1/PRKACB/TPM3/DTNA/CACNB4/TNF/ADRB1	1.15801059730168
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/555	77/9376	1.53579033579034	PLD1/CDK6/NFKB1/RB1/CCND1/CDC42/RAC2	1.18411895521231
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/555	149/9376	1.36056593506258	FCER1G/PLD1/PLCB1/AGTR1/PDGFC/SYK/LPAR6/KITLG/CYTH4/PRKCA/PLCB4/GRB2	1.1128094022691
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	24/555	333/9376	1.2175635094554	SPP1/LAMA2/WNT2/HLA-C/COL1A2/MAGI1/RBPJ/CDK6/CCND2/COL6A1/PRKACB/COL1A1/NFKB1/RB1/ATP6V1F/CCND1/LAMA4/ATP6V0B/PTGER4/TNF/CDC42/GRB2/ATP6V1A/ATP6V1G1	1.01397004640976
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/555	93/9376	1.45322096289838	LMO7/PTPRB/PTPRJ/NLK/CDC42/RAC2/WAS/CDH5	1.10174352524793
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	10/555	122/9376	1.38472899128637	PTPRC/LCP2/CD28/NFKB1/JUN/CD4/TNF/CDC42/GRB2/VAV1	1.07286060956177
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	11/555	137/9376	1.35642796080752	CTSC/TUBA1B/CTSZ/ITPR2/CTSD/CTSS/NFKB1/CTSB/JUN/TNF/TNFRSF10B	1.05412662947885
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	14/555	184/9376	1.28538973756365	NRP1/EPHA3/SLIT3/CFL1/ROBO2/GNAI2/ROBO1/FES/PRKCA/UNC5C/EFNB2/CDC42/RAC2/ABLIM3	0.980653255676061
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	13/555	169/9376	1.2995148995149	RPS27A/UBA52/CTSD/PRKACB/ATG7/UBB/CTSB/GABARAP/HMGB1/TANK/VAMP8/GABARAPL2/HIF1A	0.985543801687458
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	12/555	155/9376	1.30789886660854	WNT2/CDK6/PLCB1/ITPR2/GNAI2/PRKACB/AGTR1/RB1/CCND1/AHR/PLCB4/CDKN2C	0.969523068612353
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/555	83/9376	1.42476934766091	CCL4/CCL4L2/IFI16/NFKB1/PYCARD/NLRP3/POLR2L	0.97496149898726
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/555	41/9376	1.64816523840914	RB1/CCND1/MMP2/MMP1	1.04326279965708
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/555	28/9376	1.81003861003861	ATP6V1F/ATP6V1A/ATP6V1G1	1.07670964226259
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/555	99/9376	1.36514696514697	IGF1/PRKACB/JUN/RB1/CCND1/MMP2/CDKN2C/GRB2	0.916124996737769
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	21/555	298/9376	1.19049519317976	CXCL14/CCL3/CCL2/CCL4/BMP5/CCL4L2/CSH1/CCL3L1/EDA/IL12RB2/TNFSF13B/CD4/CSF1R/CCL8/BMP4/TNFRSF11A/TNFRSF25/TNF/CCR1/TNFRSF1B/TNFRSF10B	0.838243670949302
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/555	70/9376	1.44803088803089	HGF/JUN/ELOB/CDC42/GRB2/HIF1A	0.943731976866922
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	11/555	144/9376	1.29049049049049	CD14/C1QA/C1QB/C1QC/LY96/NFKB1/C2/C3AR1/CCND1/TNF/TLR4	0.881126954131966
Human Diseases	Substance dependence	hsa05034	Alcoholism	14/555	191/9376	1.23828121315032	GNG2/GNGT1/HDAC9/GNG11/GNG10/CALM2/GNAI2/CALM3/PRKACB/GNG5/CALM1/HDAC8/GNB4/GRB2	0.834526485604382
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/555	71/9376	1.42763608679102	CCND2/NFKB1/CCND1/CGA/TNFRSF11A/GRB2	0.907232398565747
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/555	30/9376	1.68936936936937	FOLR2/NFKB1/TNF	0.948577764756359
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/555	73/9376	1.38852276934469	CDK6/IGF1/HGF/PDGFC/RB1/CCND1	0.835871685278264
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/555	17/9376	1.98749337572867	CD209/NRP2	1.02215591643752
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/555	120/9376	1.26702702702703	CALM2/CALM3/NFKB1/JUN/CALM1/CDC42/GRB2/SH2B3/ARHGDIB	0.738426696246512
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/555	60/9376	1.40780780780781	PRKCB/PRKCA/KDR/CDC42/RAC2	0.794858166165108
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/555	18/9376	1.87707707707708	MANBA/MAN2B1	0.934234091956199
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	12/555	168/9376	1.20669240669241	FTL/CYBB/PPIA/FTH1/PYCARD/SLC25A5/NLRP3/HMGB1/TNF/TLR4/JAK3/TNFRSF10B	0.678062499802271
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/555	32/9376	1.58378378378378	ATG7/GABARAP/GABARAPL2	0.829724320428908
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	8/555	107/9376	1.26307990233224	PLCB1/ITPR2/CALM2/CALM3/PRKACB/LDHB/CALM1/PLCB4	0.686493356039738
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/555	77/9376	1.31639171639172	RUNX1/CDK6/NFKB1/RB1/CCND1/GRB2	0.699238869433795
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/555	63/9376	1.34076934076934	PTGDS/HPGDS/GPX4/TBXAS1/LTC4S	0.680705416025516
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	11/555	157/9376	1.18363459000402	HLA-C/CDK6/ITPR2/CCND2/CALM2/CALM3/NFKB1/CALM1/RB1/CCND1/SLC25A5	0.582016942477765
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/555	49/9376	1.37907703621989	GNAI2/PRKACB/NFKB1/JUN	0.667310174845708
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/555	65/9376	1.2995148995149	PLCB1/ITPR2/PRKACB/AGTR1/PLCB4	0.607785262526933
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/555	21/9376	1.60892320892321	CSGALNACT1/CHST11	0.700686092526373
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/555	21/9376	1.60892320892321	DPYD/ENPP1	0.700686092526373
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/555	51/9376	1.32499558381911	ENPP2/PLD1/LPCAT2/PLD3	0.583729102576301
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/555	99/9376	1.19450359450359	LAMA2/RYR2/IGF1/TPM3/DTNA/CACNB4/TNF	0.487994210244556
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/555	37/9376	1.36975894813733	TPM3/CCND1/NCOA4	0.565252622244371
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	12/555	180/9376	1.12624624624625	CCL2/B2M/CD74/HLA-C/HLA-DRA/BST2/SYK/NFKB1/TNF/POU2F2/HLA-DPA1/HLA-DMA	0.428971524032004
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/555	38/9376	1.33371266002845	PTPRC/CD4/JAK3	0.517024073447048
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/555	23/9376	1.46901684292989	AGTR1/ATP6AP2	0.564872078988597
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/555	23/9376	1.46901684292989	ATP1B3/ATP1B1	0.564872078988597
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	15/555	232/9376	1.09226467847158	TMSB4X/CFL1/ARPC3/ARPC1B/PFN1/PDGFC/ITGB2/ITGAM/NCKAP1L/ARPC5/ACTR2/CDC42/RAC2/VAV1/BRK1	0.356931251799472
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	8/555	119/9376	1.13571050041638	CCL2/VCAM1/NFKB1/JUN/ICAM1/JUNB/TNF/TNFRSF1B	0.373701653504853
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/555	73/9376	1.15710230778724	BST2/PPIA/CD4/BICD1/FEZ1	0.337991441255076
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/555	106/9376	1.11562128165902	FOLR2/IGF1/PDGFC/NFKB1/RB1/CCND1/GRB2	0.300278379520891
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/555	90/9376	1.12624624624625	CD28/NFKB1/JUN/CD4/TLR4/HIF1A	0.301855162375315
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	10/555	156/9376	1.08292908292908	CDK6/CD81/NFKB1/YWHAB/RB1/CCND1/EIF3E/TNF/GRB2/CLDN5	0.261985297831863
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/555	75/9376	1.12624624624625	CDK6/IGF1/CCND2/CCND1/TNFRSF10B	0.275332515172638
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/555	59/9376	1.14533516567415	NME2/DPYD/NME3/ENPP1	0.280887159857755
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/555	59/9376	1.14533516567415	GNAI2/PRKACB/CGA/ADRB1	0.280887159857755
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	9/555	144/9376	1.05585585585586	RBPJ/PLCB1/ITPR2/PRKCB/PRKCA/SLC25A5/PSMA7/PLCB4/RYR1	0.169424135219034
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	8/555	128/9376	1.05585585585586	GUCY1A2/PDE4D/NME2/FHIT/GUCY1A1/PDE4B/NME3/ENPP1	0.1595963680037
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	10/555	163/9376	1.03642292599348	PRKCB/NFKB1/YWHAB/JUN/RB1/PRKCA/TNF/GRB2/TLR4/JAK3	0.117663379177986
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/555	62/9376	1.08991572217379	IGF1/PRKACB/HSPA1A/HSPA8	0.178170821907637
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/555	46/9376	1.10176263219741	FTL/BLVRB/FTH1	0.173540020581637
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/555	47/9376	1.07832087406555	LDHB/ME1/ME2	0.135015032944177
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/555	133/9376	1.01616202668834	IGF1/CCND2/CCND1/KLF2/GABARAP/NLK/GABARAPL2/GRB2	0.0470856296385536
NA	NA	hsa03272	Virion - Hepatitis viruses	3/555	48/9376	1.05585585585586	CD81/CD63/CLDN5	0.0973124214638403
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/555	31/9376	1.08991572217379	DPYD/HIBCH	0.125776657587966
NA	NA	hsa04981	Folate transport and metabolism	2/555	31/9376	1.08991572217379	FOLR2/SLCO2B1	0.125776657587966
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/555	32/9376	1.05585585585586	LDHB/HIBCH	0.0793872034978276
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/555	50/9376	1.01362162162162	LAP3/GATM/SAT2	0.0242236357674086
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	8/555	138/9376	0.979344561953258	CALM2/MKNK1/CALM3/PRKACB/RPS6/CALM1/GRB2/PRKAR1A	-0.0613137943099279
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/555	86/9376	0.982191493819401	AREG/PRKCB/JUN/PRKCA/GRB2	-0.0416142506518692
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/555	87/9376	0.970901936419178	AREG/JUN/CCND1/GRB2/RAC2	-0.0683931256678368
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/555	70/9376	0.965353925353925	CD36/NFKB1/TNF/TNFRSF1B	-0.0729784695428516
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/555	52/9376	0.974636174636175	IGF1/PRKACB/CGA	-0.046003249784905
Cellular Processes	Cell motility	hsa04814	Motor proteins	11/555	194/9376	0.957889848611498	TUBA1B/KIF1B/TPM3/TUBB/CAPZA2/TNNT3/MYL6/MYO5A/MYO1B/DYNLL1/CAPZB	-0.148659354331318
NA	NA	hsa04519	Cadherin signaling	23/555	404/9376	0.961769690482562	WNT2/PRICKLE1/VIM/ARPC3/ARPC1B/NFKB1/YWHAB/SCN1B/NCKAP1L/KDR/CDH11/ARPC5/MYO1B/ACTR2/PCDH12/CDC42/ADAM10/EVL/RAC2/CDH5/VAV1/TMC6/BRK1	-0.197027607141099
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/555	16/9376	1.05585585585586	MIF	0.0560872305824315
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/555	109/9376	0.929928093230845	CD36/PRKCB/NFKB1/SLC27A4/TNF/TBC1D4	-0.184569876527208
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	12/555	217/9376	0.93421347614896	GNAI2/PRKACB/PRKCB/NFKB1/JUN/RB1/CCND1/ARRB2/PRKCA/AHR/GRB2/ADRB1	-0.245932539928569
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/555	110/9376	0.921474201474201	BMP5/DCN/PITX2/THSD4/BMP4/TNF	-0.207795326078552
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/555	56/9376	0.905019305019305	KRTCAP2/ST6GAL1/TMEM258	-0.178811159376453
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/555	94/9376	0.898600728387962	CCL2/NFKB1/JUN/TNF/MMP1	-0.247828471754351
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/555	38/9376	0.8891417733523	NAMPT/ENPP1	-0.171753663500881
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/555	59/9376	0.859001374255612	HPGDS/GPX4/LAP3	-0.272505992238549
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/555	20/9376	0.844684684684685	NPL	-0.17440438203269
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	7/555	138/9376	0.8569264917091	IGF1/ITPR2/CALM2/CALM3/PRKACB/YWHAB/CALM1	-0.424700732015292
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	8/555	157/9376	0.860825156366558	BMP5/WNT2/AREG/CCND2/ITGB2/YWHAB/CCND1/BMP4	-0.441104897283161
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/555	42/9376	0.804461604461604	IDO2/KYNU	-0.318563499079715
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	8/555	158/9376	0.855376895883225	CDK6/CCND2/YWHAB/RB1/CCND1/HDAC8/PDS5B/CDKN2C	-0.459855186519395
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/555	43/9376	0.785753195055521	CD36/SLC27A4	-0.353192251802154
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/555	22/9376	0.767895167895168	HNMT	-0.273382089342761
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/555	44/9376	0.767895167895168	KRTCAP2/TMEM258	-0.387076115349209
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	7/555	142/9376	0.832787717294759	WWP1/RPS27A/UBA52/UBB/ELOB/RHOBTB1/PRKN	-0.503605693667471
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/555	104/9376	0.812196812196812	PLD1/ETNK1/SGMS1/LPCAT2/PLD3	-0.483065627813201
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/555	86/9376	0.785753195055521	SCN9A/PLCB1/PRKACB/PLCB4	-0.500643914312958
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/555	86/9376	0.785753195055521	LAMA2/RYR2/DTNA/CACNB4	-0.500643914312958
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/555	46/9376	0.734508421464943	PSMA7/PSMB8	-0.452753756544394
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/555	24/9376	0.703903903903904	HS2ST1	-0.364300084465488
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	7/555	148/9376	0.799026053080107	WNT2/CDK6/IGF1/JUN/RB1/CCND1/GRB2	-0.618144550901646
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	8/555	170/9376	0.794997350291468	WNT2/CDK6/HGF/PRKCB/RB1/CCND1/PRKCA/GRB2	-0.676583914780897
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/555	72/9376	0.703903903903904	NFKB1/TANK/TNF	-0.632611813162916
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/555	27/9376	0.625692359025692	ELOVL2	-0.488541221162217
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/555	28/9376	0.603346203346203	ELOVL2	-0.52723532212477
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/555	28/9376	0.603346203346203	AKR1B1	-0.52723532212477
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/555	29/9376	0.582541161851507	RASSF4	-0.564741569410743
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/555	55/9376	0.614316134316134	ASAH1/SGMS1	-0.719539733328083
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/555	78/9376	0.64975744975745	PLCB1/INPP5D/PLCB4	-0.779102603529223
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/555	31/9376	0.544957861086893	PGLS	-0.63652582563425
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/555	31/9376	0.544957861086893	SRP14	-0.63652582563425
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/555	32/9376	0.527927927927928	AKR1B1	-0.670949913433252
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/555	33/9376	0.511930111930112	VAMP8	-0.704480584612642
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/555	82/9376	0.618061964403428	NME2/DPYD/NME3	-0.871308038828994
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/555	59/9376	0.572667582837074	CCND1/GRB2	-0.825899144334852
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/555	34/9376	0.496873343932167	POLR2L	-0.737174108055792
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/555	35/9376	0.482676962676963	AKR1B1	-0.769081515829359
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/555	150/9376	0.675747747747748	WNT2/HGF/RARB/RB1/CCND1/GRB2	-1.00414198127006
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/555	85/9376	0.596248012718601	NME2/NME3/ENPP1	-0.937920707800713
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/555	36/9376	0.469269269269269	AKR1B1	-0.800249232255152
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/555	36/9376	0.469269269269269	ENPP1	-0.800249232255152
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/555	62/9376	0.544957861086893	RBPJ/TLE4	-0.901680261612726
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/555	63/9376	0.536307736307736	PRDM6/SMYD3	-0.926250684852849
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/555	63/9376	0.536307736307736	WNT2/BMP4	-0.926250684852849
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/555	37/9376	0.456586316045776	MIF	-0.830719611698266
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/555	90/9376	0.563123123123123	IGF1/PRKACB/NFKB1	-1.04457395390963
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/555	90/9376	0.563123123123123	ATP1B3/PRKACB/ATP1B1	-1.04457395390963
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/555	41/9376	0.412041309602285	GATM	-0.946356566317177
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/555	116/9376	0.582541161851507	ME1/ME2/HIBCH/PGLS	-1.13477662180715
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/555	71/9376	0.475878695597005	LDHB/HIF1A	-1.11192633835252
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/555	44/9376	0.383947583947584	HMGB1	-1.02737704292758
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/555	144/9376	0.586586586586587	WNT2/IGF1/BMP4/GRB2/JAK3	-1.25398150260683
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/555	168/9376	0.603346203346203	CSH1/IL12RB2/CCND2/CCND1/GRB2/JAK3	-1.30123824681856
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/555	47/9376	0.359440291355185	TNF	-1.10424189205298
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/555	48/9376	0.351951951951952	HIBCH	-1.1290333630052
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/555	49/9376	0.344769259054973	ST6GAL1	-1.15343874338691
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/555	83/9376	0.407076956474547	MBD5/KDM2B	-1.36092009106348
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/555	110/9376	0.460737100737101	IGF1/GNAI2/PRKACB	-1.42699994266961
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/555	54/9376	0.312846179512846	LDHB	-1.27019241438594
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/555	57/9376	0.296380591117433	ELOVL2	-1.33648411539145
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	12/555	323/9376	0.627629487072212	ZEB2/MARCKS/CDK6/CCND2/VIM/PRKCB/NFKB1/FSCN1/STMN1/CCND1/PRKCA/GRB2	-1.70825815513951
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/555	122/9376	0.415418697385911	CD36/IGF1/CCND1	-1.6301715411775
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/555	63/9376	0.268153868153868	POLR2L	-1.46190271847897
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	5/555	174/9376	0.485450968209589	HSPA1A/KRTCAP2/HSPA8/TMEM258/PRKN	-1.71843652019551
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/555	65/9376	0.25990297990298	AKR1B1	-1.50182866489649
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/555	67/9376	0.252144681995428	LDHB	-1.54090793357585
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/555	154/9376	0.438797238797239	NME2/IDO2/KYNU/NME3	-1.76133035299201
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/555	70/9376	0.241338481338481	HPGDS	-1.59804413915751
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/555	73/9376	0.231420461557448	HPGDS	-1.65352953483768
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/555	78/9376	0.216585816585817	CNOT2	-1.74267812268105
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/555	79/9376	0.213844223970806	HPGDS	-1.76004575665471
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	12/555	370/9376	0.547903579254931	SPX/CSH1/KISS1/AGTR1/LPAR6/C3AR1/TAC3/CGA/PTGER4/HRH2/HRH1/ADRB1	-2.22555933909899
NA	NA	hsa04382	Cornified envelope formation	5/555	217/9376	0.389255615062067	S100A4/S100A10/S100A6/SLC27A4/CLDN5	-2.28317152271184
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/555	108/9376	0.156423089756423	SUMO2	-2.21165187526164
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/555	243/9376	0.208564119675231	HSPA1A/HSPA8/SNRPD1	-3.13534519075206
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/555	183/9376	0.0923152660857579	NOP10	-3.11032065735331
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/555	449/9376	0.225750917955818	CALM2/CALM3/PRKACB/CALM1/ARRB2/GRK3	-4.21720119552542