category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	16/269	88/9376	6.33727610679284	F13A1/C1QA/C1QB/C1QC/CR1/SERPINE2/VSIG4/C7/CFD/C2/C4BPB/F3/C3AR1/VTN/PROS1/A2M	8.64517945754893
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	23/269	205/9376	3.91056306102094	MT-ATP6/CD36/MT-CYB/MT-CO2/MT-ND1/MT-CO3/MT-ND3/MT-ND2/COL3A1/MT-ND4/MT-CO1/CYBB/COL1A1/MT-ND5/RYR2/COL1A2/CYBA/NCF4/TBC1D4/MT-ND4L/COX4I2/MT-ND6/UQCRB	7.24135280130486
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	27/269	275/9376	3.42212909766813	MT-ATP6/C1QA/MT-CYB/MT-CO2/MT-ND1/MT-CO3/MT-ND3/C1QB/MT-ND2/C1QC/MT-ND4/MT-CO1/CYBB/MT-ND5/ITPR2/RYR2/C7/LAMC1/CYBA/NCF4/TUBA1B/EGR1/MT-ND4L/COX4I2/MT-ND6/UQCRB/RYR1	7.00637190942894
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	21/269	204/9376	3.58801661928712	DCN/LUM/HGF/GPC3/ACTB/COL1A1/FN1/WNT2/ITPR2/COL1A2/CD63/TWIST1/IGF2/CTSL/ANK2/VTN/TLR4/TIMP3/CCND1/IGF1/FZD2	6.42279752700515
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	14/269	103/9376	4.73757534197134	COL3A1/COL1A1/COL14A1/COL15A1/SLC16A10/SLC8A1/COL1A2/COL6A1/COL21A1/COL5A1/COL11A1/KCNQ1/COL5A2/COL8A2	6.55499777022514
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	17/269	155/9376	3.82280849022665	CD36/CD14/MRC1/CYBB/ACTB/FCGR3A/COLEC12/FCGR2A/CYBA/NCF4/CD209/FCGR1A/TUBA1B/CTSL/CLEC7A/MSR1/TLR4	6.09021133139765
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	21/269	238/9376	3.07544281653182	F13A1/C1QA/C1QB/C1QC/NRP1/CCL2/CYBB/RPL27A/RPS11/RPL23/IL6ST/C7/FCGR2A/CFD/C2/UBA52/C3AR1/TLR4/RPS23/RPL38/RPL13A	5.57375382762549
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/269	50/9376	6.27390334572491	HBA2/HBB/HBA1/CD36/HGF/CCL2/CR1/LRP1/TLR4	6.42604219310155
NA	NA	hsa04518	Integrin signaling	15/269	154/9376	3.39496934292473	SPP1/LAMA2/HGF/ACTB/COL1A1/FN1/PDGFC/COL1A2/LAMC1/FREM1/COL6A1/VTN/CCND1/IGF1/PDGFRA	5.15017361929467
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	14/269	138/9376	3.53601637842789	MT-ATP6/MT-CYB/MT-CO2/MT-ND1/MT-CO3/MT-ND3/MT-ND2/MT-ND4/MT-CO1/MT-ND5/MT-ND4L/COX4I2/MT-ND6/UQCRB	5.15794525320237
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	25/269	362/9376	2.40711454332601	SPP1/LAMA2/HGF/CSF1R/COL1A1/FN1/PDGFC/PRLR/CSH1/GNGT1/COL1A2/LAMC1/MAGI1/GNG10/IGF2/COL6A1/KITLG/VTN/TLR4/LPAR6/CCND1/IGF1/PDGFRA/ANGPT1/FGF7	4.69244369351659
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	18/269	233/9376	2.69266238013945	DCN/LAMA2/COL3A1/ACTB/COL1A1/FN1/NEBL/VCAN/FMNL2/COL1A2/TNNT3/COL6A1/FBLN1/ANK2/COL5A1/TNNT1/COL11A1/COL5A2	4.49653576964224
NA	NA	hsa04517	IgSF CAM signaling	21/269	299/9376	2.44801133891161	SLIT2/NRP1/ACTB/CADM3/MTSS1/PMP22/PTPRD/MAGI1/CD28/NRCAM/CD209/CD86/TUBA1B/ROBO1/ROBO2/UNC5C/ARPC1B/ANK2/IL1RAPL1/NFASC/EPB41L2	4.37331237502954
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/269	89/9376	3.91629422329894	SPP1/CD36/LAMA2/COL1A1/FN1/COL1A2/LAMC1/FREM1/COL6A1/VTN	4.75075602763118
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	10/269	99/9376	3.52070894821824	C1QA/C1QB/C1QC/FCGR3A/FCGR2A/CFD/C2/FCGR1A/C3AR1/KRT18	4.3332189326743
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	18/269	268/9376	2.34100871109138	MT-ATP6/MT-CYB/MT-CO2/MT-ND1/MT-CO3/MT-ND3/MT-ND2/MT-ND4/MT-CO1/MT-ND5/ITPR2/TUBA1B/UBA52/SNCA/MT-ND4L/COX4I2/MT-ND6/UQCRB	3.82790891288354
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	23/269	388/9376	2.06614800904457	MT-ATP6/MT-CYB/MT-CO2/MT-ND1/MT-CO3/MT-ND3/MT-ND2/MT-ND4/MT-CO1/CYBB/MT-ND5/WNT2/ITPR2/APOE/TUBA1B/LRP1/SNCA/MT-ND4L/COX4I2/MT-ND6/UQCRB/LRP6/FZD2	3.68617492958686
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	16/269	227/9376	2.45674139822806	MT-ATP6/MT-CYB/MT-CO2/MT-ND1/MT-CO3/MT-ND3/MT-ND2/MT-ND4/HGF/MT-CO1/MT-ND5/CYBA/MT-ND4L/COX4I2/MT-ND6/UQCRB	3.81841112829443
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	12/269	149/9376	2.80711559092837	MT-ND1/MT-ND3/MT-ND2/MT-ND4/MT-ND5/ITPR2/GNGT1/GNG10/MT-ND4L/MT-ND6/KCNJ5/GRIA4	3.82140367227963
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	16/269	235/9376	2.37310764850115	MT-ATP6/MT-CYB/MT-CO2/MT-ND1/MT-CO3/MT-ND3/MT-ND2/MT-ND4/MT-CO1/ACTB/MT-ND5/PRKG1/MT-ND4L/COX4I2/MT-ND6/UQCRB	3.66366514564535
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	19/269	308/9376	2.150147250519	MT-ATP6/MT-CYB/MT-CO2/MT-ND1/MT-CO3/MT-ND3/MT-ND2/MT-ND4/MT-CO1/MT-ND5/TUBA1B/CLTA/MT-ND4L/COX4I2/MT-ND6/GRIA4/AP2S1/UQCRB/CLTC	3.52733865750614
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/269	78/9376	3.57487370126775	C1QA/CD14/C1QB/C1QC/LY96/C2/C4BPB/TLR4	3.92448408199562
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/269	78/9376	3.57487370126775	CYBB/CR1/FCGR3A/FCGR2A/CYBA/NCF4/FCGR1A/TLR4	3.92448408199562
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	9/269	98/9376	3.20097109475761	MARCKS/FCGR3A/PLPP3/FCGR2A/FCGR1A/HCK/ARPC1B/SCIN/MYO10	3.76421397470284
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	14/269	203/9376	2.40379438533521	SPP1/LAMA2/HGF/ACTB/COL1A1/FN1/PDGFC/COL1A2/LAMC1/COL6A1/VTN/CCND1/IGF1/PDGFRA	3.47512101854114
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	9/269	101/9376	3.10589274540837	COL3A1/CCL2/CYBB/COL1A1/FN1/COL1A2/EGR1/F3/CCND1	3.65690843447636
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	25/269	480/9376	1.81536555142503	MT-ATP6/MT-CYB/MT-CO2/MT-ND1/MT-CO3/MT-ND3/MT-ND2/MT-ND4/MT-CO1/CYBB/MT-ND5/WNT2/ITPR2/RYR2/TUBA1B/UBA52/SNCA/MT-ND4L/COX4I2/MT-ND6/GRIA4/UQCRB/RYR1/LRP6/FZD2	3.15173504204504
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/269	87/9376	3.20505918044695	MT-CYB/MT-CO2/MT-CO3/MT-CO1/RYR2/SLC8A1/COX4I2/UQCRB	3.55115398482784
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/269	52/9376	4.02173291392622	CD36/PLTP/NPC2/APOE/ABCA1/LRP1	3.75517969911411
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	13/269	201/9376	2.25430468475467	CD14/IGFBP3/MEF2C/MAF/CSF1R/BMP2K/RUNX1T1/FCGR1A/CD86/PROM1/HPGD/SPI1/IGF1	3.08938580332348
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/269	97/9376	2.87464070823593	PRKG1/GNGT1/RYR2/GNG10/KCNJ5/GRIA4/RYR1/GUCY1A2	3.18953544861209
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/269	42/9376	4.14940697468579	FTL/CYBB/SLC40A1/FTH1/NCOA4	3.51555293600851
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	10/269	140/9376	2.48964418481147	SPP1/MEF2C/ITPR2/GNGT1/RYR2/SLC8A1/GNG10/EGR1/CCND1/RYR1	3.05195911379332
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	10/269	143/9376	2.43741388722801	C1QA/C1QB/C1QC/FCGR3A/C7/FCGR2A/CD28/C2/FCGR1A/CD86	2.9768198106332
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/269	103/9376	2.70718590969791	CD14/LAMA2/COL3A1/COL1A1/FN1/COL1A2/LAMC1/TLR4	2.99408006730032
Organismal Systems	Immune system	hsa04611	Platelet activation	9/269	126/9376	2.48964418481147	COL3A1/ACTB/COL1A1/PRKG1/ITPR2/COL1A2/FCGR2A/TBXAS1/GUCY1A2	2.89315073780311
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	12/269	195/9376	2.14492422076065	CYBB/ACTB/CR1/FCGR3A/HDAC9/FCGR2A/CYBA/NCF4/FCGR1A/CLEC7A/TLR4/CLCN5	2.77666294651875
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/269	68/9376	3.07544281653182	CD14/CSF1R/RUNX1T1/FCGR1A/SPI1/CCND1	2.95196463981997
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/269	89/9376	2.74140595630926	PRKG1/ITPR2/PDGFC/TUBA1B/GJA1/PDGFRA/GUCY1A2	2.83681762196496
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	10/269	157/9376	2.22006487817583	C1QA/CD36/C1QB/C1QC/STAB1/GAS6/ABCA1/LRP1/PROS1/ELMO1	2.64950628442106
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	10/269	160/9376	2.17843866171004	CADM3/VCAN/PTPRD/CD28/NRCAM/CD86/SIGLEC1/CD4/CDH5/NFASC	2.58386518574713
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/269	53/9376	3.2882093006944	SLC8A1/CLTA/KL/AP2S1/CLTC	2.87097855897852
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/269	73/9376	2.86479604827621	HGF/PDGFC/CCND1/IGF1/PDGFRA/FGF7	2.74887739339296
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/269	142/9376	2.20912089638201	CSF1R/FCGR3A/ITPR2/FCGR2A/CYBA/NCF4/FCGR1A/SPI1/LILRB5	2.49512940189171
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	9/269	144/9376	2.17843866171004	C1QA/CD14/C1QB/C1QC/LY96/C2/C3AR1/TLR4/CCND1	2.44914467443167
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/269	78/9376	2.68115527595082	ACTB/FN1/CLTA/ARPC1B/ELMO1/CLTC	2.56232650035749
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/269	100/9376	2.43985130111524	CD36/CD14/CSF1R/CR1/FCGR1A/KITLG/CD4	2.48777662620984
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/269	60/9376	2.90458488228005	PRKG1/ITPR2/IGF1/RYR1/GUCY1A2	2.54352100185069
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/269	63/9376	2.76627131645719	PTGDS/HPGDS/HPGD/TBXAS1/LTC4S	2.41744721140641
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/269	65/9376	2.68115527595082	SPP1/ITPR2/KISS1/CGA/KCNJ5	2.33743989803311
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	12/269	238/9376	1.75739589516104	HGF/CSF1R/PDGFC/GNGT1/RGL1/GNG10/IGF2/KITLG/IGF1/PDGFRA/ANGPT1/FGF7	2.034042198636
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	11/269	212/9376	1.80851511538192	HGF/CSF1R/ACTB/PDGFC/MAGI1/KITLG/MAGI3/IGF1/PDGFRA/ANGPT1/FGF7	2.04638641315697
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/269	46/9376	3.03087118150962	FTL/FTH1/BLVRB/ALAS2	2.37298274776717
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	8/269	138/9376	2.02058078767308	CCL2/ACTB/FN1/FCGR2A/ARPC1B/CD4/TLR4/ELMO1	2.07573573817026
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	5/269	70/9376	2.48964418481147	LAMA2/ACTB/CD28/CD86/CCND1	2.14992916601723
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/269	93/9376	2.24871087660391	LAMA2/FN1/LAMC1/RARB/CCND1/FHIT	2.07985617306161
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/269	95/9376	2.2013695949912	CCL2/CD28/CD86/CTSL/TLR4/ANGPT1	2.02262402981451
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	12/269	250/9376	1.67304089219331	DAB2/FOLR2/WWP1/PSD3/GRK3/CLTA/ARPC1B/SNX3/PDGFRA/AP2S1/SNX6/CLTC	1.85372511362959
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	16/269	368/9376	1.51543559075481	MT-ATP6/MT-CYB/MT-CO2/MT-ND1/MT-CO3/MT-ND3/MT-ND2/MT-ND4/MT-CO1/ACTB/MT-ND5/TUBA1B/MT-ND4L/COX4I2/MT-ND6/UQCRB	1.73363726512085
NA	NA	hsa04519	Cadherin signaling	17/269	404/9376	1.46667157422062	ACTB/CDH11/WNT2/PRICKLE1/PCDH12/PCDH10/GJA1/SCN1B/CYFIP1/ARPC1B/KRT7/PDGFRA/CDH5/FMN1/KRT18/LRP6/FZD2	1.6479024828057
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	8/269	154/9376	1.81065031622652	MEF2C/ACTB/ITPR2/RYR2/CCND1/KCNJ5/RYR1/GUCY1A2	1.7432331171322
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	9/269	181/9376	1.73312247119473	CD14/MRC1/CR1/FCGR3A/FCGR2A/CD209/FCGR1A/CLEC7A/TLR4	1.71164644328443
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	5/269	80/9376	2.17843866171004	HGF/PDGFC/GAS6/IGF1/PDGFRA	1.8191898661541
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/269	37/9376	2.82608258816437	HBA2/HBB/HBA1	1.9126926972199
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/269	61/9376	2.28557498933512	FTL/SLC40A1/FTH1/SLC8A1	1.7311911070534
NA	NA	hsa04081	Hormone signaling	10/269	219/9376	1.59155336015345	PRKG1/SLC16A10/SLC40A1/PRLR/CSH1/GNGT1/GNG10/IGF2/CGA/IGF1	1.52234640446313
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/269	86/9376	2.02645456903259	LAMA2/ACTB/RYR2/SLC8A1/GJA1	1.6434451374465
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	7/269	142/9376	1.71820514163045	MEF2C/CCL2/ACTB/CYBA/CTSL/BMP4/CDH5	1.48208071734935
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	11/269	254/9376	1.50946930890144	HGF/ITPR2/PDGFC/RYR2/SLC8A1/HRH1/EDNRB/HRH2/PDGFRA/FGF7/RYR1	1.41469872112892
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/269	91/9376	1.91511091139344	GNGT1/PDE3A/GNG10/GRK3/KCNJ5	1.50757034425532
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/269	21/9376	3.31952557974863	CHSY3/CSGALNACT1	1.82877816455983
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/269	43/9376	2.43174548283911	CD36/PLPP3/ABCA1	1.61719923184609
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/269	93/9376	1.87392573050326	PRKG1/ITPR2/CST3/LYZ/GUCY1A2	1.45561303215999
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	10/269	232/9376	1.50237149083451	TMSB4X/ACTB/FN1/PDGFC/C7/CYFIP1/ARPC1B/SCIN/PDGFRA/FGF7	1.3316036571442
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	8/269	178/9376	1.56651768931958	WNT2/RSPO2/PRICKLE1/SERPINF1/NOTUM/CCND1/LRP6/FZD2	1.31144742149287
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/269	150/9376	1.62656753407683	HGF/WNT2/RARB/CCND1/FGF7/LRP6/FZD2	1.32947722596912
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	12/269	300/9376	1.39420074349442	CD14/MEF2C/HGF/CSF1R/PDGFC/IGF2/KITLG/MKNK1/IGF1/PDGFRA/ANGPT1/FGF7	1.19262781166883
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/269	99/9376	1.76035447410912	LAMA2/ACTB/RYR2/SLC8A1/IGF1	1.30708561378424
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/269	73/9376	1.90986403218414	HGF/RARB/CCND1/FHIT	1.34122156224234
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/269	100/9376	1.74275092936803	CXCL14/CCL2/CSF1R/IL6ST/CCL8	1.28332585437552
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	13/269	333/9376	1.3607064313384	SPP1/LAMA2/RBPJ/COL1A1/FN1/WNT2/COL1A2/LAMC1/MAGI1/COL6A1/VTN/CCND1/FZD2	1.15184448440403
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	9/269	216/9376	1.45229244114002	CD36/CD14/CCL2/CYBB/LY96/CYBA/NCF4/ABCA1/TLR4	1.15577308965465
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	8/269	187/9376	1.49112378983361	CCL2/CYBB/ITPR2/CYBA/NAMPT/TLR4/GABARAP/ANTXR1	1.16587438077096
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/269	130/9376	1.60869316557049	COL3A1/COL1A1/GNGT1/COL1A2/GNG10/EDNRB	1.20106708953652
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/269	103/9376	1.69199119356119	C1QA/C1QB/C1QC/CCL2/TLR4	1.21362121583791
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/269	76/9376	1.83447466249266	ACTB/ITPR2/HRH2/KCNQ1	1.25531461846069
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/269	51/9376	2.05029521102121	ENPP2/PLPP3/LPCAT2	1.29254646123236
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	10/269	250/9376	1.39420074349442	LGMN/NPC2/CTSC/CD68/CD63/CTSL/CLTA/CTSZ/AP2S1/CLTC	1.08572870757634
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/269	105/9376	1.65976278987431	LAMA2/ACTB/RYR2/SLC8A1/IGF1	1.16840467750497
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/269	52/9376	2.01086645696311	HSD17B2/CGA/IGF1	1.25622790161525
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/269	106/9376	1.6441046503472	FOLR2/PDGFC/CCND1/IGF1/PDGFRA	1.14615567791785
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/269	193/9376	1.44476760983878	CXCL14/CCL2/GNGT1/GNG10/GRK3/CCL8/HCK/ELMO1	1.07298493532432
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/269	79/9376	1.76481106771446	SYT1/CLTA/AP2S1/CLTC	1.17319554226502
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/269	166/9376	1.46978994043087	MEF2C/PRKG1/ITPR2/SLC8A1/PDE3A/EDNRB/GUCY1A2	1.04954738733241
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/269	137/9376	1.52649716440995	ACTB/ITPR2/CTSC/TUBA1B/CTSL/CTSZ	1.06688582861189
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	8/269	196/9376	1.42265381989227	ITPR2/GNGT1/IL6ST/GNG10/CD86/UBA52/HCK/CCND1	1.02769821787085
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/269	54/9376	1.93638992152003	CD28/CD86/CGA	1.18596854680289
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/269	109/9376	1.59885406364039	SPP1/CD14/LY96/CD86/TLR4	1.08078368028319
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	5/269	110/9376	1.58431902669821	CYBB/MKNK1/TLR4/IGF1/ANGPT1	1.05943503970372
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/269	170/9376	1.43520664771485	HGF/ACTB/WNT2/IGF2/CCND1/LRP6/FZD2	0.984143902047362
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/269	56/9376	1.8672331386086	DISP1/GRK3/CCND1	1.11865464927616
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/269	56/9376	1.8672331386086	CD14/CR1/TLR4	1.11865464927616
NA	NA	hsa04981	Folate transport and metabolism	2/269	31/9376	2.24871087660391	FOLR2/SLCO2B1	1.1968154818318
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	6/269	144/9376	1.45229244114002	WNT2/IL6ST/BMP4/KLF4/IGF1/FZD2	0.939997693130977
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/269	115/9376	1.51543559075481	MEF2C/ITPR2/EGR1/KL/LRP6	0.955803224253325
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/269	298/9376	1.28659464584217	CXCL14/BMP5/CCL2/CSF1R/EDA/PRLR/CSH1/IL6ST/CCL8/BMP4/CD4	0.864082531456403
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	5/269	116/9376	1.50237149083451	CYBB/ACTB/CYBA/NCF4/CDH5	0.935669766600094
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/269	116/9376	1.50237149083451	ITPR2/GNGT1/GNG10/GRK3/GRIA4	0.935669766600094
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/269	148/9376	1.41304129408219	WNT2/CCND1/IGF1/FGF7/LRP6/FZD2	0.870451639059569
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/269	10/9376	3.48550185873606	SELENBP1	1.35148467503833
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/269	370/9376	1.22463578820456	SPX/PRLR/CSH1/TAC3/KISS1/HRH1/EDNRB/LYPD6/C3AR1/CGA/LPAR6/HRH2/GRIA4	0.757683706942667
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/269	63/9376	1.65976278987431	WNT2/BMP4/FZD2	0.902999274069924
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/269	122/9376	1.42848436833445	ACTB/SLC16A10/BMP4/TBC1D4/CCND1	0.818699001262926
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/269	36/9376	1.93638992152003	ENPP1/PYGL	0.967405724331358
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	7/269	184/9376	1.32600614191046	SLIT2/NRP1/EPHA3/ROBO1/ROBO2/UNC5C/SEMA6D	0.767544909596622
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/269	37/9376	1.88405505877625	NCOA4/CCND1	0.925985311848029
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/269	12/9376	2.90458488228005	CD209	1.13457801323445
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/269	157/9376	1.3320389269055	BMP5/ACTB/WNT2/BMP4/CCND1/FZD2	0.721059379091282
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	6/269	157/9376	1.3320389269055	MT-CYB/MT-CO2/MT-CO3/MT-CO1/COX4I2/UQCRB	0.721059379091282
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/269	38/9376	1.83447466249266	ENPP1/NAMPT	0.885833556674721
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/269	39/9376	1.78743685063388	CD28/CD86	0.846873355373961
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/269	69/9376	1.51543559075481	ITPR2/PDE3A/GUCY1A2	0.738530101970856
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/269	101/9376	1.38039677573705	WNT2/EDNRB/KITLG/FZD2	0.660563640134811
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/269	41/9376	1.70024480913954	ALAS2/GATM	0.772251526158347
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/269	71/9376	1.47274726425467	PRLR/CGA/CCND1	0.687185710096168
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/269	133/9376	1.31033904463762	ITPR2/GNGT1/GNG10/KCNJ5/GRIA4	0.619483684479541
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	7/269	200/9376	1.21992565055762	ACTB/FCGR2A/TUBA1B/CYFIP1/ARPC1B/TLR4/MYO10	0.540304134217769
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/269	105/9376	1.32781023189945	CD14/EDA/LY96/TLR4	0.58053441958779
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/269	44/9376	1.58431902669821	CD28/CD86	0.667671919282617
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/269	75/9376	1.39420074349442	IGFBP3/CCND1/IGF1	0.589057050494878
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/269	45/9376	1.54911193721603	CD28/CD86	0.634566523325936
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/269	76/9376	1.3758559968695	CD36/PLTP/ME1	0.565406654645483
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/269	76/9376	1.3758559968695	CCND1/IGF1/PDGFRA	0.565406654645483
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/269	110/9376	1.26745522135857	BMP5/DCN/PITX2/BMP4	0.484925905391279
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/269	17/9376	2.05029521102121	INMT	0.744895296859619
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/269	17/9376	2.05029521102121	CA8	0.744895296859619
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/269	17/9376	2.05029521102121	CD209	0.744895296859619
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/269	47/9376	1.48319228031322	ME1/MDH2	0.570723137553404
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/269	112/9376	1.24482209240574	LAMA2/LY96/LAMC1/TLR4	0.447955066995158
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	8/269	248/9376	1.12435543830195	CD14/ACTB/LY96/TUBA1B/CYFIP1/ARPC1B/TLR4/ELMO1	0.341096228289842
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/269	82/9376	1.27518360685466	LGMN/CTSL/CD4	0.430132502433825
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/269	115/9376	1.21234847260385	ITPR2/GNGT1/GNG10/KCNQ1	0.393770547514587
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/269	115/9376	1.21234847260385	ITPR2/GNGT1/GNG10/KCNJ5	0.393770547514587
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/269	50/9376	1.39420074349442	CD28/CD86	0.480317981614239
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	5/269	149/9376	1.16963149622015	PDGFC/PLPP3/KITLG/LPAR6/PDGFRA	0.358709993895282
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/269	51/9376	1.36686347401414	ACTB/KCNQ1	0.451480764756921
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/269	20/9376	1.74275092936803	NPL	0.571461800342854
Genetic Information Processing	Translation	hsa03010	Ribosome	7/269	222/9376	1.09903211761948	RPL27A/RPS11/RPL23/UBA52/RPS23/RPL38/RPL13A	0.25663814578474
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/269	21/9376	1.65976278987431	ENPP1	0.520175243784971
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/269	122/9376	1.14278749466756	IGFBP3/ITPR2/CSH1/IGF1	0.272822039533358
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/269	89/9376	1.17488826698968	GNGT1/GNG10/GABARAP	0.284899747743333
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/269	22/9376	1.58431902669821	HNMT	0.471559822605692
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/269	90/9376	1.16183395291202	CD28/CD4/TLR4	0.265124991245888
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/269	93/9376	1.12435543830195	RBPJ/MAF/CD4	0.207126750356755
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/269	93/9376	1.12435543830195	ITPR2/EGR1/CGA	0.207126750356755
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/269	128/9376	1.08921933085502	ENPP1/PDE3A/FHIT/GUCY1A2	0.174668321119851
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/269	59/9376	1.18152605380883	PRKG1/CGA	0.240381496538047
NA	NA	hsa04082	Neuroactive ligand signaling	6/269	199/9376	1.050905083036	GNGT1/GNG10/TAC3/HRH1/HRH2/GRIA4	0.124741635108154
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/269	168/9376	1.03735174367145	FTL/CYBB/FTH1/PYGL/TLR4	0.0839570124303882
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	5/269	168/9376	1.03735174367145	PRLR/CSH1/IL6ST/CCND1/PDGFRA	0.0839570124303882
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/269	170/9376	1.02514760551061	ACTB/MAGI1/TUBA1B/ARPC1B/CCND1	0.0568669222869293
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/269	99/9376	1.05621268446547	ITPR2/HRH1/IGF1	0.0966322862282088
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/269	99/9376	1.05621268446547	PDGFC/PLPP3/PDGFRA	0.0966322862282088
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/269	27/9376	1.29092661434669	HMGCLL1	0.260169789153046
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/269	27/9376	1.29092661434669	ELOVL2	0.260169789153046
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/269	136/9376	1.02514760551061	CD28/CD209/TLR4/CCND1	0.0507696556137634
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/269	28/9376	1.24482209240574	ELOVL2	0.222968945076552
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/269	102/9376	1.02514760551061	ITPR2/RYR2/KCNQ1	0.0438871409049704
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/269	66/9376	1.05621268446547	MAF/TLR4	0.0787599737893366
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/269	29/9376	1.20189719266761	RASSF4	0.187140276900793
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/269	29/9376	1.20189719266761	GNGT1	0.187140276900793
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/269	30/9376	1.16183395291202	MDH2	0.15257785009118
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/269	30/9376	1.16183395291202	FOLR2	0.15257785009118
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/269	105/9376	0.995857673924588	ITPR2/CD209/CLEC7A	-0.00733583832938444
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	7/269	253/9376	0.964368103207605	CD14/ACTB/ITPR2/UBA52/ARPC1B/TLR4/ELMO1	-0.0987425809809157
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/269	31/9376	1.12435543830195	KL	0.119187328787053
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/269	31/9376	1.12435543830195	MDH2	0.119187328787053
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/269	70/9376	0.995857673924588	HPGDS/SULT1A1	-0.00597841265416549
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/269	32/9376	1.08921933085502	GABARAP	0.0868843679014303
Human Diseases	Immune disease	hsa05310	Asthma	1/269	32/9376	1.08921933085502	PRG2	0.0868843679014303
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/269	109/9376	0.959312438184237	CD36/PYGL/TBC1D4	-0.0734310000898597
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/269	34/9376	1.02514760551061	BHLHE41	0.0252458661856996
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	6/269	227/9376	0.921278024335522	CCL2/ITPR2/GNGT1/GNG10/CCND1/PDGFRA	-0.206346073698597
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/269	75/9376	0.929467162329616	ITPR2/CGA	-0.105397734547242
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	4/269	154/9376	0.905325158113262	RYR2/SLC8A1/SCN1B/KCNQ1	-0.203590026960648
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/269	36/9376	0.968194960760017	KL	-0.032858509383994
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/269	155/9376	0.899484350641564	WNT2/ITPR2/CCND1/FZD2	-0.216862585196628
Cellular Processes	Cell motility	hsa04814	Motor proteins	5/269	194/9376	0.898325221323727	ACTB/TNNT3/TUBA1B/TNNT1/MYO10	-0.245934562285827
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	4/269	157/9376	0.888025951270334	IGFBP3/ITPR2/ZFP36L1/CCND1	-0.243164073573606
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/269	158/9376	0.88240553385723	WNT2/IGF1/LRP6/FZD2	-0.256195316603089
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/269	38/9376	0.917237331246331	IGF1	-0.0878564113653943
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/269	38/9376	0.917237331246331	CD4	-0.0878564113653943
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/269	122/9376	0.85709062100067	CD36/CCND1/IGF1	-0.273054922196211
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/269	41/9376	0.850122404569771	GRIA4	-0.165289624853004
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/269	41/9376	0.850122404569771	CCND1	-0.165289624853004
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	5/269	205/9376	0.850122404569771	RBPJ/IL6ST/HDAC9/SCIN/CCND1	-0.37288886128474
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/269	42/9376	0.829881394937157	INMT	-0.189896372969714
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	4/269	169/9376	0.824970854138712	WDFY3/CTSL/UBA52/GABARAP	-0.394610615474754
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/269	44/9376	0.792159513349104	MAN1A1	-0.237488855036906
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/269	45/9376	0.774555968608013	ABCA1	-0.260528365000223
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/269	90/9376	0.774555968608013	KL/IGF1	-0.36933440587546
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/269	133/9376	0.78620342678257	CCND1/GABARAP/IGF1	-0.426770305555616
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	5/269	214/9376	0.814369593162631	ITPR2/GNGT1/GNG10/CD4/TLR4	-0.472101053278851
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/269	134/9376	0.780336237030461	PRKG1/ITPR2/GUCY1A2	-0.44015125657952
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/269	93/9376	0.749570292201303	ACTB/CDH5	-0.417116390544863
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/269	48/9376	0.726146220570012	HMGCLL1	-0.326903220338785
NA	NA	hsa03272	Virion - Hepatitis viruses	1/269	48/9376	0.726146220570012	CD63	-0.326903220338785
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/269	94/9376	0.741596140156608	S100A9/CCL2	-0.432729249220083
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/269	49/9376	0.711326909946134	GXYLT2	-0.348182919593141
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/269	139/9376	0.752266588216416	ITPR2/KCNJ5/KRT18	-0.505708929285961
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/269	50/9376	0.697100371747212	GATM	-0.369071191455377
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	5/269	224/9376	0.778013807753585	NRP1/EGR1/CD4/SPI1/CCND1	-0.577917805419556
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/269	98/9376	0.711326909946134	ITPR2/KCNJ5	-0.493703566707259
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	3/269	142/9376	0.736373632127336	WWP1/UBA52/UBE2E2	-0.544016651735363
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/269	99/9376	0.704141789643648	CCND1/IGF1	-0.508594377549805
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/269	144/9376	0.726146220570012	RBPJ/ITPR2/RYR1	-0.569149288169714
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/269	54/9376	0.645463307173344	MDH2	-0.449032349362955
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/269	55/9376	0.633727610679284	PLPP3	-0.46819673650713
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/269	104/9376	0.670288818987704	PLPP3/LPCAT2	-0.581082428733731
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/269	56/9376	0.622411046202868	MAN1A1	-0.48705661704553
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/269	105/9376	0.663905115949726	UBA52/GABARAP	-0.595206096246559
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/269	57/9376	0.611491554164221	ELOVL2	-0.505623611465879
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/269	107/9376	0.651495674530105	ITPR2/PYGL	-0.623099970079395
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/269	59/9376	0.590763026904417	ENPP1	-0.541922186745787
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/269	59/9376	0.590763026904417	HPGDS	-0.541922186745787
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/269	59/9376	0.590763026904417	CCND1	-0.541922186745787
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/269	109/9376	0.639541625456158	IL6ST/CD4	-0.650538340276385
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/269	62/9376	0.562177719150977	IGF1	-0.594428600443142
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/269	62/9376	0.562177719150977	RBPJ	-0.594428600443142
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/269	63/9376	0.553254263291438	PRDM6	-0.611448663266559
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/269	65/9376	0.536231055190163	PLPP3	-0.644813748363685
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/269	65/9376	0.536231055190163	ITPR2	-0.644813748363685
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/269	116/9376	0.600948596333803	ME1/MDH2	-0.743235515036002
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/269	66/9376	0.528106342232736	HSD17B2	-0.661173407221506
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/269	67/9376	0.520224158020307	ITPR2	-0.677326975569134
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/269	69/9376	0.50514519691827	GRIA4	-0.709041390885577
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/269	122/9376	0.57139374733378	CD28/CD4	-0.81893188392578
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/269	70/9376	0.497928836962294	CD36	-0.724614272211299
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/269	70/9376	0.497928836962294	HGF	-0.724614272211299
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/269	71/9376	0.490915754751558	PDGFRA	-0.740005167711269
NA	NA	hsa04382	Cornified envelope formation	4/269	217/9376	0.642488821886831	S100A9/S100A11/KRT7/KRT18	-0.915734491850851
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	3/269	173/9376	0.604422287642091	CCL2/ACTB/TLR4	-0.902535441318384
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/269	73/9376	0.477466008046036	HPGDS	-0.770262184483607
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/269	73/9376	0.477466008046036	CD4	-0.770262184483607
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	4/269	226/9376	0.61690298384709	RYR2/PDE3A/CGA/GRIA4	-1.00190501818788
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/269	77/9376	0.452662579056631	CCND1	-0.828812877300777
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/269	77/9376	0.452662579056631	CCND1	-0.828812877300777
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/269	79/9376	0.441202766928615	HPGDS	-0.857176955909499
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	6/269	323/9376	0.647461645585646	MARCKS/FSCN1/ZFPM2/TIMP3/CCND1/PDGFRA	-1.10811665880216
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/269	138/9376	0.50514519691827	ITPR2/IGF1	-1.00647377686184
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/269	138/9376	0.50514519691827	PYGL/MKNK1	-1.00647377686184
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/269	83/9376	0.419939982980248	HMGCLL1	-0.912237914634633
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/269	191/9376	0.547461024932365	GNGT1/HDAC9/GNG10	-1.08594342990684
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/269	85/9376	0.410059042204242	ENPP1	-0.938989836799972
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/269	86/9376	0.405290913806519	SCN9A	-0.952182186515158
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/269	86/9376	0.405290913806519	RYR2	-0.952182186515158
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/269	87/9376	0.400632397555869	CCND1	-0.965256020641026
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/269	91/9376	0.383022182278688	LILRB5	-1.01642046825089
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/269	98/9376	0.355663454973067	ITPR2	-1.10197750119442
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	2/269	158/9376	0.441202766928615	CDKN1C/CCND1	-1.21741471975257
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	3/269	217/9376	0.481866616415123	CCND1/KLF4/FGF7	-1.32715461718477
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/269	110/9376	0.316863805339642	IGF1	-1.23860149754604
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/269	117/9376	0.297906141772313	ACTB	-1.31334907537584
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/269	119/9376	0.292899315860173	CCL2	-1.33411637939662
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/269	133/9376	0.262067808927523	FCGR3A	-1.47302429559077
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	2/269	205/9376	0.340048961827908	RBPJ/CCND1	-1.64192913838301
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/269	154/9376	0.226331289528316	ALAS2	-1.66370738503028
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	1/269	156/9376	0.223429606329235	CCND1	-1.68093832009514
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/269	163/9376	0.213834469861108	TLR4	-1.74012871860606
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	1/269	174/9376	0.200316198777934	MAN1A1	-1.82989393794747
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	1/269	180/9376	0.193638992152003	CCL2	-1.87732904842826
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/269	449/9376	0.232884311274124	PRKG1/SLC8A1/GRK3	-2.86289472190008