category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	83/353	222/9376	9.93042901258199	RPLP1/RPL28/RPS12/RPS18/RPS23/RPS14/RPL13/RPS2/RPL7A/RPS4X/RPL23A/RPS27A/RPL15/RPL26/RPS15/RPL10/RPLP2/RPL19/RPS11/RPS8/RPL41/RPL12/RPL32/RPS28/RPL11/RPS19/RPL13A/RPL35/RPS16/RPL29/UBA52/RPL36/RPL8/RPL18A/RACK1/RPS24/RPS7/RPL10A/RPL21/RPS3/RPL27A/RPS5/RPS9/RPL14/RPL30/RPS13/RPLP0/RPL37A/RPL24/RPL27/FAU/RPL23/RPL7/RPS6/RPL3/RPL17/RPS15A/RPL37/RPL35A/RPL39/RPL34/RPL18/RPL9/RPS25/RPL6/RPL5/RPSA/RPS20/RPL22/RPS21/RPS3A/RPS26/RPS10/RPS17/RPL36AL/RPL4/RPL38/RPS27L/RPL36A/MRPL14/RPL31/MRPS34/RPS27	26.6342742941928
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	85/353	238/9376	9.48603804127883	RPLP1/RPL28/RPS12/RPS18/RPS23/RPS14/RPL13/RPS2/RPL7A/RPS4X/RPL23A/RPS27A/RPL15/RPL26/RPS15/RPL10/RPLP2/RPL19/RPS11/RPS8/RPL41/RPL12/RPL32/RPS28/RPL11/RPS19/RPL13A/RPL35/RPS16/RPL29/UBA52/RPL36/RPL8/RPL18A/RPS24/RPS7/RPL10A/RPL21/RPS3/RPL27A/RPS5/RPS9/RPL14/RPL30/RPS13/RPLP0/RPL37A/RPL24/RPL27/FAU/RPL23/CCL2/RPL7/RPS6/RPL3/RPL17/RPS15A/RPL37/RPL35A/RPL39/RPL34/RPL18/RPL9/RPS25/RPL6/RPL5/RPSA/RPS20/RPL22/RPS21/RPS3A/RPS26/RPS10/RPS17/RPL36AL/F13A1/RPL4/RPL38/RPS27L/RPL36A/TNFRSF1A/RPL31/RPS27/CFB/ISG15	26.2280128742686
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	47/353	138/9376	9.046105842263	MT-CO2/ATP5F1E/UQCR11/ATP5MG/NDUFA4/COX4I1/NDUFS5/NDUFA13/COX6B1/COX8A/UQCRQ/NDUFC2/COX6C/NDUFB2/UQCRH/ATP5MC3/COX7C/UQCR10/UQCRB/MT-ATP6/ATP5MF/COX6A1/COX7B/ATP5F1D/COX5B/ATP6V0B/NDUFS6/COX7A2/NDUFA11/ATP5MC2/NDUFB7/ATP6V0E1/ATP5PF/ATP6V1F/NDUFB3/ATP6V0C/ATP5F1A/MT-CYB/ATP6V1G1/ATP5MC1/NDUFB8/NDUFS8/NDUFB10/NDUFA7/NDUFV2/NDUFAB1/COX5A	18.8336206111397
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	52/353	205/9376	6.73740067712292	MT-CO2/ATP5F1E/CD36/UQCR11/NDUFA4/COL3A1/GAPDH/COX4I1/NDUFS5/COL1A1/NDUFA13/CYBA/COX6B1/COX8A/SLC25A6/G6PD/UQCRQ/NDUFC2/COX6C/NDUFB2/UQCRH/ATP5MC3/COX7C/UQCR10/UQCRB/MT-ATP6/COX6A1/COX7B/ATP5F1D/COX5B/NDUFS6/COL1A2/SLC25A5/COX7A2/NDUFA11/RAC1/ATP5MC2/NDUFB7/ATP5PF/NDUFB3/ATP5F1A/MT-CYB/ATP5MC1/GFPT2/NDUFB8/NDUFS8/NDUFB10/NDUFA7/NDUFV2/NDUFAB1/PPP1CA/COX5A	16.4278707145162
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	58/353	268/9376	5.74825588770031	MT-CO2/RPS27A/UBA52/UCHL1/TUBB3/ATP5F1E/UQCR11/NDUFA4/COX4I1/NDUFS5/NDUFA13/COX6B1/COX8A/SLC25A6/UQCRQ/NDUFC2/COX6C/NDUFB2/UQCRH/ATP5MC3/COX7C/UQCR10/UQCRB/TXN/MT-ATP6/COX6A1/PSMA7/COX7B/ATP5F1D/COX5B/GNAI2/NDUFS6/SLC25A5/COX7A2/NDUFA11/ATP5MC2/NDUFB7/TUBA1B/ATP5PF/PSMA2/NDUFB3/UBB/TUBB/PARK7/ATP5F1A/MT-CYB/SEM1/ATP5MC1/NDUFB8/PSMB3/NDUFS8/NDUFB10/NDUFA7/NDUFV2/NDUFAB1/CALM2/COX5A/PSMB1	15.5986679631842
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	58/353	308/9376	5.00172914903793	MT-CO2/TUBB3/ATP5F1E/UQCR11/NDUFA4/COX4I1/NDUFS5/NDUFA13/POLR2L/AP2S1/COX6B1/COX8A/SLC25A6/UQCRQ/NDUFC2/COX6C/NDUFB2/CLTA/UQCRH/ATP5MC3/COX7C/UQCR10/UQCRB/MT-ATP6/COX6A1/PSMA7/COX7B/ATP5F1D/COX5B/NDUFS6/AP2M1/SLC25A5/COX7A2/NDUFA11/ATP5MC2/NDUFB7/TUBA1B/ATP5PF/PSMA2/NDUFB3/TUBB/ATP5F1A/MT-CYB/SEM1/GRIA4/ATP5MC1/NDUFB8/POLR2J/PSMB3/NDUFS8/CLTC/NDUFB10/NDUFA7/NDUFV2/DCTN3/NDUFAB1/COX5A/PSMB1	14.1242307946245
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	50/353	227/9376	5.85041993735258	MT-CO2/ATP5F1E/CYP1B1/UQCR11/NDUFA4/NQO1/COX4I1/NDUFS5/NDUFA13/CYBA/COX6B1/COX8A/SLC25A6/UQCRQ/NDUFC2/COX6C/MGST1/NDUFB2/UQCRH/ATP5MC3/COX7C/UQCR10/UQCRB/MT-ATP6/COX6A1/COX7B/ATP5F1D/COX5B/NDUFS6/SLC25A5/COX7A2/NDUFA11/RAC1/ATP5MC2/NDUFB7/MAP2K2/ATP5PF/NDUFB3/ATP5F1A/MT-CYB/GSTM3/ATP5MC1/NDUFB8/NDUFS8/NDUFB10/NDUFA7/NDUFV2/MGST3/NDUFAB1/COX5A	14.6319755707748
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	52/353	275/9376	5.02242595930981	MT-CO2/TUBB3/ATP5F1E/UQCR11/NDUFA4/COX4I1/NDUFS5/NDUFA13/CYBA/COX6B1/COX8A/SLC25A6/UQCRQ/NDUFC2/COX6C/NDUFB2/UQCRH/ATP5MC3/COX7C/UQCR10/UQCRB/MT-ATP6/COX6A1/PSMA7/COX7B/ATP5F1D/COX5B/NDUFS6/SLC25A5/COX7A2/NDUFA11/RAC1/ATP5MC2/NDUFB7/TUBA1B/ATP5PF/PSMA2/NDUFB3/TUBB/ATP5F1A/MT-CYB/SEM1/ATP5MC1/NDUFB8/PSMB3/NDUFS8/NDUFB10/NDUFA7/NDUFV2/NDUFAB1/COX5A/PSMB1	13.3908258110003
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	47/353	235/9376	5.31218130311615	MT-CO2/ACTB/ACTG1/ATP5F1E/RPS6/UQCR11/ATP5MG/NDUFA4/COX4I1/NDUFS5/NDUFA13/COX6B1/COX8A/UQCRQ/NDUFC2/COX6C/NDUFB2/UQCRH/ATP5MC3/COX7C/UQCR10/UQCRB/MT-ATP6/ATP5MF/COX6A1/COX7B/ATP5F1D/COX5B/NDUFS6/COX14/COX7A2/NDUFA11/ATP5MC2/NDUFB7/ATP5PF/PRKG1/NDUFB3/ATP5F1A/MT-CYB/ATP5MC1/NDUFB8/NDUFS8/NDUFB10/NDUFA7/NDUFV2/NDUFAB1/COX5A	13.2413297536832
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	56/353	368/9376	4.04187707845794	MT-CO2/ACTB/ACTG1/TUBB3/ATP5F1E/PFN1/UQCR11/NDUFA4/COX4I1/NDUFS5/NDUFA13/COX6B1/COX8A/UQCRQ/NDUFC2/COX6C/NDUFB2/UQCRH/ATP5MC3/COX7C/UQCR10/UQCRB/MT-ATP6/COX6A1/PSMA7/COX7B/ATP5F1D/COX5B/NDUFS6/COX7A2/NDUFA11/RAC1/ATP5MC2/NDUFB7/TUBA1B/TNFRSF1A/ATP5PF/PSMA2/NDUFB3/TUBB/PFN2/ATP5F1A/MT-CYB/SEM1/ATP5MC1/NDUFB8/PSMB3/NDUFS8/NDUFB10/NDUFA7/NDUFV2/DCTN3/NDUFAB1/OPTN/COX5A/PSMB1	11.7746740344567
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	62/353	480/9376	3.43078375826251	MT-CO2/RPS27A/UBA52/UCHL1/TUBB3/ATP5F1E/UQCR11/NDUFA4/COX4I1/NDUFS5/NDUFA13/COX6B1/COX8A/SLC25A6/UQCRQ/NDUFC2/COX6C/NDUFB2/UQCRH/ATP5MC3/COX7C/UQCR10/UQCRB/MT-ATP6/COX6A1/PSMA7/COX7B/ATP5F1D/COX5B/NDUFS6/SLC25A5/COX7A2/NDUFA11/RAC1/ATP5MC2/NDUFB7/TUBA1B/MAP2K2/TNFRSF1A/ATP5PF/PSMA2/NDUFB3/UBB/TUBB/PARK7/ATP5F1A/MT-CYB/SEM1/GRIA4/ATP5MC1/NDUFB8/PSMB3/NDUFS8/NDUFB10/NDUFA7/NDUFV2/DCTN3/NDUFAB1/CALM2/OPTN/COX5A/PSMB1	10.8135195473411
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	54/353	388/9376	3.69662100990041	MT-CO2/TUBB3/ATP5F1E/UQCR11/NDUFA4/GAPDH/COX4I1/NDUFS5/NDUFA13/COX6B1/COX8A/SLC25A6/UQCRQ/NDUFC2/COX6C/NDUFB2/UQCRH/ATP5MC3/COX7C/UQCR10/UQCRB/MT-ATP6/COX6A1/PSMA7/COX7B/ATP5F1D/COX5B/NDUFS6/SLC25A5/COX7A2/NDUFA11/ATP5MC2/NDUFB7/TUBA1B/MAP2K2/TNFRSF1A/ATP5PF/PSMA2/NDUFB3/TUBB/ATP5F1A/MT-CYB/SEM1/ATP5MC1/NDUFB8/PSMB3/NDUFS8/NDUFB10/NDUFA7/NDUFV2/NDUFAB1/CALM2/COX5A/PSMB1	10.7300502792713
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	34/353	157/9376	5.75204344923405	MT-CO2/UQCR11/NDUFA4/COX4I1/NDUFS5/NDUFA13/COX6B1/COX8A/UQCRQ/NDUFC2/COX6C/NDUFB2/UQCRH/COX7C/UQCR10/UQCRB/COX6A1/COX7B/COX5B/NDUFS6/COX7A2/NDUFA11/RAC1/NDUFB7/TNFRSF1A/NDUFB3/MT-CYB/NDUFB8/NDUFS8/NDUFB10/NDUFA7/NDUFV2/NDUFAB1/COX5A	11.8764278244298
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	18/353	87/9376	5.49535996874084	MT-CO2/UQCR11/COX4I1/COX6B1/COX8A/UQCRQ/COX6C/UQCRH/COX7C/UQCR10/UQCRB/COX6A1/COX7B/COX5B/COX7A2/MT-CYB/ASPH/COX5A	8.33176728111037
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	21/353	149/9376	3.7434834686389	NDUFA4/NDUFS5/NDUFA13/NDUFC2/NDUFB2/GNG10/GNAI2/NDUFS6/NDUFA11/NDUFB7/NDUFB3/GNB2/GRIA4/NDUFB8/NDUFS8/GNG11/NDUFB10/NDUFA7/NDUFV2/NDUFAB1/GNGT1	6.67671338957464
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	20/353	155/9376	3.4272137439459	ACTB/ACTG1/TUBB3/CD36/CYBA/SEC61G/CALR/ATP6V0B/HLA-C/RAC1/ITGA2/TUBA1B/CD14/ATP6V0E1/ATP6V1F/TUBB/FCGR3A/ATP6V0C/ATP6V1G1/SEC61B	6.02673884757198
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	25/353	248/9376	2.67751073745774	ACTB/ACTG1/TUBB3/RPS3/PFN1/ARPC1B/GAPDH/DYNLL1/TXN/MYL12A/MYL12B/ARPC3/RAC1/TUBA1B/BRK1/MAP2K2/TNFRSF1A/CD14/AHNAK2/TUBB/PFN2/S100A10/ARPC1A/DYNLRB1/DCTN3	5.29542529484775
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	16/353	142/9376	2.99277819893867	ACTB/ACTG1/CCL2/NQO1/CYBA/MGST1/PLAT/GSTP1/TXN/SUMO2/RAC1/TNFRSF1A/GSTM3/GPC1/MGST3/CALM2	4.73266443852025
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/353	51/9376	4.68721879686719	ACTB/ACTG1/SEC61G/ATP6V0B/ATP6V0E1/ATP6V1F/ATP6V0C/ATP6V1G1/SEC61B	5.22224315242134
Organismal Systems	Immune system	hsa04611	Platelet activation	13/353	126/9376	2.74041098970277	ACTB/ACTG1/COL3A1/COL1A1/MYL12A/MYL12B/GNAI2/COL1A2/ITGA2/VAMP8/FCER1G/PRKG1/PPP1CA	3.89012660131201
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	19/353	232/9376	2.17524665429325	TMSB4X/ACTB/ACTG1/CFL1/PFN1/ARPC1B/ITGA3/MYL12A/MYL12B/ARPC3/RAC1/ITGA2/BRK1/MAP2K2/ITGA11/PFN2/ENAH/ARPC1A/PPP1CA	3.58510945547333
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/353	78/9376	3.06471998256701	ACTB/ACTG1/ARPC1B/CLTA/CTTN/ARPC3/RAC1/ARPC1A/CLTC	3.62168941306376
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/353	79/9376	3.02592605873705	AP2S1/CLTA/ATP6V0B/AP2M1/ATP6V0E1/ATP6V1F/ATP6V0C/ATP6V1G1/CLTC	3.57654120619312
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/353	59/9376	3.15129399337399	GPX4/G6PD/MGST1/GSTP1/HPGDS/GSTM3/MGST3	3.27857584528359
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/353	46/9376	3.46446606724966	POMP/PSMA7/PSMA2/SEM1/PSMB3/PSMB1	3.31404536453713
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	15/353	204/9376	1.953007832028	ACTB/ACTG1/CD63/RPS6/COL1A1/CTTN/COL1A2/RAC1/DCN/ITGA2/MAP2K2/GPC1/CCND1/PPP1CA/LUM	2.72193056679877
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	10/353	116/9376	2.28973332030868	PKM/GAPDH/G6PD/PGLS/TKT/GPI/TPI1/PGAM1/MDH2/ENO1	2.7645276213228
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	7/353	67/9376	2.77502008371739	PKM/GAPDH/LDHB/GPI/TPI1/PGAM1/ENO1	2.88394298168306
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/353	52/9376	3.06471998256701	CD36/ANGPTL4/TSPO/NPC2/LRPAP1/PLTP	2.95297120808207
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	17/353	253/9376	1.78472494373467	ACTB/RPS27A/ACTG1/UBA52/PFN1/ARPC1B/MYL12A/MYL12B/CTTN/ARPC3/RAC1/TNFRSF1A/CD14/UBB/PFN2/RBX1/ARPC1A	2.50268616570927
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	15/353	214/9376	1.86174578380239	CFL1/ELOB/GNG10/CALR/GNAI2/HLA-C/RAC1/MAP2K2/TNFRSF1A/B2M/GNB2/RBX1/GNG11/CALM2/GNGT1	2.52225169412858
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	8/353	86/9376	2.47078200144937	ACTB/ACTG1/ITGA3/CDH2/ITGA2/ITGA11/GJA1/DSG2	2.71011167689629
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	11/353	140/9376	2.08692836908134	RPS6/PLAT/GNG10/GNAI2/SPP1/MAP2K2/GNB2/GNG11/CCND1/CALM2/GNGT1	2.5628340888801
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	8/353	89/9376	2.38749721488366	CD36/COL1A1/ITGA3/SPP1/COL1A2/ITGA2/COL6A1/ITGA11	2.6012788674968
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	14/353	200/9376	1.85926345609065	ACTB/ACTG1/TUBB3/RPS3/ARPC1B/GAPDH/CTTN/ARPC3/RAC1/TUBA1B/BRK1/TNFRSF1A/TUBB/ARPC1A	2.42947340633743
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/353	28/9376	3.79441521651153	ATP6V0E1/ATP6V1F/ATP6V0C/ATP6V1G1	2.92892407297439
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/353	42/9376	3.16201268042628	FTL/GPX4/FTH1/SLC7A11/NCOA4	2.77745157632256
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	14/353	203/9376	1.83178665624695	ACTB/ACTG1/COL1A1/ITGA3/MYL12A/MYL12B/SPP1/COL1A2/RAC1/ITGA2/COL6A1/ITGA11/CCND1/PPP1CA	2.36974591569383
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	12/353	170/9376	1.87488751874688	ACTB/ACTG1/MYL6/ARPC1B/MYL12A/MYL12B/CTTN/ARPC3/RAC1/TUBA1B/ARPC1A/CCND1	2.2768724830372
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/353	31/9376	3.4272137439459	G6PD/PGLS/TKT/GPI	2.6772980944256
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/353	31/9376	3.4272137439459	SRP14/SEC61G/SPCS1/SEC61B	2.6772980944256
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/353	97/9376	2.19059022808913	GNG10/GNAI2/PRKG1/GNB2/GRIA4/GNG11/CALM2/GNGT1	2.33128358470906
NA	NA	hsa04518	Integrin signaling	11/353	154/9376	1.89720760825577	ACTB/ACTG1/COL1A1/ITGA3/SPP1/COL1A2/RAC1/ITGA2/COL6A1/ITGA11/CCND1	2.22043600742193
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	13/353	196/9376	1.76169277909464	RPS27A/UBA52/GNG10/HLA-C/RAC1/MAP2K2/TNFRSF1A/UBB/GNB2/GNG11/CCND1/CALM2/GNGT1	2.13149366271719
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/353	20/9376	3.98413597733711	SQLE/DHCR24/MSMO1	2.64232365116199
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/353	70/9376	2.27664912990692	CYP1B1/MGST1/GSTP1/HPGDS/GSTM3/MGST3	2.12049162582984
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	14/353	227/9376	1.63811758245872	CCL2/GNG10/CALR/GNAI2/HLA-C/RAC1/MAP2K2/TNFRSF1A/B2M/GNB2/GNG11/CCND1/CALM2/GNGT1	1.92497165161212
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/353	89/9376	2.0890600630232	TUBB3/GNAI2/TUBA1B/MAP2K2/PRKG1/TUBB/GJA1	2.04176909112897
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/353	71/9376	2.24458364920401	ATP6V0B/RAC1/ATP6V0E1/ATP6V1F/ATP6V0C/ATP6V1G1	2.08205687550947
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	15/353	250/9376	1.59365439093484	CD63/AP2S1/CLTA/CTSC/NPC2/ATP6V0B/AP2M1/LAMTOR1/VAMP8/ATP6V0E1/LAMTOR4/ATP6V1F/ATP6V0C/ATP6V1G1/CLTC	1.88174585780307
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	8/353	110/9376	1.93170229204224	RPS6/ELOB/GAPDH/LDHB/TIMP1/MAP2K2/RBX1/ENO1	1.94412806967839
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	9/353	130/9376	1.8388319895402	COL3A1/COL1A1/GNG10/GNAI2/COL1A2/MAP2K2/GNB2/GNG11/GNGT1	1.90487827219844
NA	NA	hsa04517	IgSF CAM signaling	17/353	299/9376	1.5101518754678	ACTB/ACTG1/TUBB3/MYL6/ARPC1B/DYNLL1/CDH2/MYL12A/MYL12B/ARPC3/SLIT3/RAC1/TUBA1B/CADM3/MAP2K2/TUBB/ARPC1A	1.77321512168528
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/353	75/9376	2.12487252124646	PKM/GAPDH/TKT/TPI1/PGAM1/ENO1	1.93449062575572
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	11/353	174/9376	1.67913776822637	SEC61G/CALR/STUB1/SSR4/TUSC3/TMEM258/OSTC/P4HB/CKAP4/RBX1/SEC61B	1.78849983747916
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/353	76/9376	2.09691367228269	CD36/ANGPTL4/DBI/FADS2/SCD/PLTP	1.89904512165638
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/353	116/9376	1.83178665624695	ACTB/ACTG1/CYBA/MYL12A/MYL12B/GNAI2/RAC1/CD99	1.78292453954129
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/353	79/9376	2.01728403915803	CYP1B1/MGST1/GSTP1/HPGDS/GSTM3/MGST3	1.79589885265576
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	18/353	333/9376	1.43572467651788	PKM/COL1A1/ITGA3/ATP6V0B/SPP1/COL1A2/HLA-C/ITGA2/MAP2K2/TNFRSF1A/ATP6V0E1/ATP6V1F/COL6A1/ITGA11/ATP6V0C/ATP6V1G1/ISG15/CCND1	1.6013103831639
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/353	27/9376	2.95121183506453	FADS1/FADS2/SCD	2.00817351907424
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/353	44/9376	2.41462786505279	MGAT4B/TUSC3/TMEM258/OSTC	1.86028161446007
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	7/353	103/9376	1.80511015154432	COL3A1/COL1A1/DPP4/COL1A2/COL6A1/COL14A1/COL5A1	1.62502967945585
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/353	105/9376	1.77072710103872	RPS27A/UBA52/GABARAP/TOMM7/UBB/FIS1/OPTN	1.57083113798258
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	13/353	233/9376	1.4819389901397	ACTB/ACTG1/COL3A1/COL1A1/ITGA3/COL1A2/DCN/ITGA2/COL6A1/ITGA11/ENO1/COL5A1/DSG2	1.47340851761166
NA	NA	hsa03272	Virion - Hepatitis viruses	4/353	48/9376	2.21340887629839	CD63/DPP4/CD81/CD9	1.66698245826258
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/353	170/9376	1.5624062656224	ACTB/ACTG1/NQO1/MGST1/GSTP1/TXNRD1/MAP2K2/GSTM3/MGST3/CCND1	1.46364798107702
Cellular Processes	Cell motility	hsa04814	Motor proteins	11/353	194/9376	1.50603078181128	ACTB/ACTG1/TUBB3/MYL6/DYNLL1/MYL12A/MYL12B/TUBA1B/TUBB/DYNLRB1/DCTN3	1.40866157654929
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/353	89/9376	1.79062291116275	GNG10/GABARAP/GNAI2/GNB2/GNG11/GNGT1	1.48225931476114
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	5/353	70/9376	1.89720760825577	ACTB/ACTG1/HLA-C/RAC1/CCND1	1.49024596920838
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/353	154/9376	1.55226077039108	ACTB/ACTG1/MYL6/GNAI2/MAP2K2/EEF2/CCND1/CALM2/PPP1CA	1.36675133913194
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/353	71/9376	1.87048637433667	PKM/G6PD/LDHB/MAP2K2/PGAM1	1.45623168188344
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	8/353	133/9376	1.59764851221538	GNG10/GNAI2/GNB2/GRIA4/GNG11/CALM2/PPP1CA/GNGT1	1.3729752196729
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/353	53/9376	2.00459671815704	AP2S1/CLTA/AP2M1/CLTC	1.45060563426044
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	12/353	224/9376	1.42290570619183	SLC25A6/CALR/TSPO/ANAPC11/FDPS/SLC25A5/HLA-C/MAP2K2/TNFRSF1A/B2M/RAN/CCND1	1.26708882497995
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/353	73/9376	1.81924017230005	MGST1/GSTP1/HPGDS/GSTM3/MGST3	1.38982036799277
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/353	18/9376	2.95121183506453	PRDX1/CD320	1.63887815273748
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/353	95/9376	1.67753093782615	CCL2/ATP6V0B/ATP6V0E1/ATP6V1F/ATP6V0C/ATP6V1G1	1.3127773032163
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	8/353	138/9376	1.5397626965554	ACTB/ACTG1/CCL2/ARPC1B/ARPC3/RAC1/MAP2K2/ARPC1A	1.26342929688718
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/353	56/9376	1.89720760825577	MGAT4B/TUSC3/TMEM258/OSTC	1.33191502234416
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/353	37/9376	2.15358701477682	MAP2K2/NCOA4/CCND1	1.39058821776998
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	6/353	98/9376	1.62617794993351	CFL1/ARPC1B/ARPC3/RAC1/FCGR3A/ARPC1A	1.23248356401371
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	8/353	142/9376	1.49638909946934	RPS27A/UBA52/ELOB/STUB1/ANAPC11/UBB/RBX1/UBE2M	1.17887833175754
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/353	100/9376	1.59365439093484	CD36/ITGA3/ITGA2/CD14/CD59/CD9	1.18045877973538
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	11/353	212/9376	1.37816024373296	ACTB/ACTG1/PFN1/GNAI2/EFNA5/RAC1/MAP2K2/ID1/PFN2/ENAH/CALM2	1.10153619390609
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/353	101/9376	1.57787563458895	CCL2/COL3A1/COL1A1/COL1A2/RAC1/CCND1	1.15487671040653
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/353	82/9376	1.61956747046224	NME2/MGST1/GSTP1/GSTM3/MGST3	1.11452986918863
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/353	61/9376	1.74169878790693	FTL/FTH1/ATOX1/MT2A	1.14947245691463
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	9/353	173/9376	1.38178126381634	ACTB/ACTG1/CCL2/SLC25A6/FDPS/SLC25A5/MAP2K2/TNFRSF1A/IL33	1.00246787473149
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/353	63/9376	1.68640676289401	GPX4/PTGDS/PTGIS/HPGDS	1.08119627121537
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/353	63/9376	1.68640676289401	POLR2L/GTF2H5/RBX1/POLR2J	1.08119627121537
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/353	85/9376	1.5624062656224	NME2/GUK1/APRT/AK1/HDDC2	1.03021031851528
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	12/353	250/9376	1.27492351274788	DAB2/ARPC1B/AP2S1/CLTA/ARPC3/AP2M1/SNX3/FOLR2/HLA-C/SNX6/ARPC1A/CLTC	0.871443367093302
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/353	110/9376	1.44877671903168	BMP5/BAMBI/DCN/ID1/RBX1/PITX2	0.936435837863221
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/353	88/9376	1.509142415658	PLAT/F13A1/SERPINB2/CD59/CFB	0.949111036885725
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/353	46/9376	1.73223303362483	FTL/FTH1/BLVRB	0.984656889008607
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/353	91/9376	1.45939046788905	GNG10/GNAI2/GNB2/GNG11/GNGT1	0.870982108447254
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/353	47/9376	1.69537701163281	PKM/LDHB/MDH2	0.945255523828656
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/353	70/9376	1.51776608660461	ELOB/RAC1/MAP2K2/RBX1	0.860000312586921
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/353	116/9376	1.37383999218521	GNG10/GNAI2/GNB2/GRIA4/GNG11/GNGT1	0.801321457759778
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	5/353	93/9376	1.42800572664413	ACTB/ACTG1/MYL12A/MYL12B/RAC1	0.820435400259999
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	16/353	362/9376	1.1739627189207	RPS6/COL1A1/ITGA3/GNG10/EFNA5/SPP1/COL1A2/RAC1/ITGA2/MAP2K2/COL6A1/ITGA11/GNB2/GNG11/CCND1/GNGT1	0.667650544286949
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/353	50/9376	1.59365439093484	CD36/CCL2/CD81	0.832469811310917
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/353	29/9376	1.83178665624695	CALM2/GNGT1	0.887303794642847
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	7/353	144/9376	1.29115517784073	SLC25A6/PSMA7/SLC25A5/PSMA2/SEM1/PSMB3/PSMB1	0.696394573417304
NA	NA	hsa04382	Cornified envelope formation	10/353	217/9376	1.22400490855211	S100A9/S100A6/KRT19/KRT8/S100A11/KRT18/S100A13/S100A16/S100A10/DSG2	0.660329781225655
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/353	75/9376	1.41658168083097	MGST1/GSTP1/GSTM3/MGST3	0.716413052330674
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/353	99/9376	1.34145992502933	ACTB/ACTG1/ITGA3/ITGA2/ITGA11	0.675540003627768
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/353	76/9376	1.39794244818846	ACTB/ACTG1/GNAI2/CALM2	0.688942698069985
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/353	78/9376	1.36209777002978	CFL1/GNAI2/CD14/CALM2	0.63514940102455
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	5/353	103/9376	1.28936439396023	PRDX1/COL3A1/COL1A1/COL1A2/CD14	0.584051421362861
NA	NA	hsa04519	Cadherin signaling	17/353	404/9376	1.11766190783384	ACTB/ACTG1/ARPC1B/KRT19/CDH2/PCDH7/KRT8/ARPC3/RAC1/BRK1/MAP2K2/KRT18/GJA1/ENAH/ARPC1A/PPP1CA/DSG2	0.478166832305927
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/353	56/9376	1.42290570619183	EEF1A1/EEF1G/CD14	0.627808388971425
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/353	105/9376	1.26480507217051	ACTB/ACTG1/ITGA3/ITGA2/ITGA11	0.539703420705676
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/353	57/9376	1.39794244818846	FADS1/FADS2/SCD	0.596033337676645
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/353	34/9376	1.5624062656224	POLR2L/POLR2J	0.649781271558861
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/353	34/9376	1.5624062656224	BHLHE41/RBX1	0.649781271558861
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/353	12/9376	2.21340887629839	NQO1	0.831887503206805
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/353	106/9376	1.25287294884815	PLAT/GSTP1/FOLR2/MAP2K2/CCND1	0.517860696176772
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	7/353	157/9376	1.18424423954819	SLC25A6/SLC25A5/HLA-C/MAP2K2/CCND1/CALM2/PPP1CA	0.460467888485676
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/353	35/9376	1.51776608660461	AKR1B1/TPI1	0.606971709389055
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/353	158/9376	1.17674902284218	RPS6/LAMTOR1/MAP2K2/TNFRSF1A/LAMTOR4/ATP6V1F/ATP6V1G1	0.443164256748038
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	6/353	133/9376	1.19823638416154	HCST/HLA-C/RAC1/MAP2K2/FCER1G/FCGR3A	0.455407547293049
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	8/353	184/9376	1.15482202241655	CFL1/MYL12A/MYL12B/GNAI2/EFNA5/SLIT3/RAC1/ENAH	0.419502112494716
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/353	60/9376	1.32804532577904	GNAI2/MAP2K2/PRKG1	0.504187705702583
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/353	37/9376	1.43572467651788	MIF/FAH	0.525243084046524
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/353	37/9376	1.43572467651788	GPI/GFPT2	0.525243084046524
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/353	137/9376	1.16325138024441	ACTB/ACTG1/CTSC/TUBA1B/MAP2K2/TNFRSF1A	0.380716916205235
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/353	38/9376	1.39794244818846	GPI/GFPT2	0.486163828255876
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/353	166/9376	1.12003822656063	SLC25A6/GNAI2/SLC25A5/MAP2K2/PRKG1/CALM2/PPP1CA	0.308632254779811
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/353	115/9376	1.15482202241655	GNG10/GNAI2/GNB2/GNG11/GNGT1	0.330407750795272
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/353	115/9376	1.15482202241655	GNG10/GNAI2/GNB2/GNG11/GNGT1	0.330407750795272
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/353	15/9376	1.77072710103872	AK1	0.590857359686049
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/353	193/9376	1.10097021826241	CXCL14/CCL2/GNG10/GNAI2/RAC1/GNB2/GNG11/GNGT1	0.280334900933547
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	7/353	168/9376	1.1067044381492	FTL/FTH1/SLC25A6/PPIA/SLC25A5/TNFRSF1A/IL33	0.276027264285793
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/353	169/9376	1.1001558911779	RPS27A/UBA52/GABARAP/VAMP8/MAP2K2/UBB/OPTN	0.259871284191825
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	8/353	195/9376	1.08967821602382	ACTB/ACTG1/CYBA/SLC25A6/SLC25A5/RAC1/MAP2K2/FCGR3A	0.250297657087824
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/353	16/9376	1.6600566572238	MIF	0.522637773221148
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/353	41/9376	1.29565397636979	MAP2K2/CCND1	0.375245941505844
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/353	67/9376	1.18929432159317	MAP2K2/CALM2/PPP1CA	0.307553720230463
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/353	68/9376	1.1718046992168	MAP2K2/CD14/CCND1	0.281228169310095
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/353	17/9376	1.5624062656224	TXNRD1	0.459047260190161
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/353	17/9376	1.5624062656224	CA12	0.459047260190161
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/353	17/9376	1.5624062656224	PCDH7	0.459047260190161
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/353	69/9376	1.15482202241655	RAC1/MAP2K2/FCER1G	0.255299483926118
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/353	69/9376	1.15482202241655	GRIA4/CALM2/PPP1CA	0.255299483926118
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/353	44/9376	1.2073139325264	HLA-C/CPE	0.272624558463563
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/353	125/9376	1.06243626062323	GNAI2/RAC1/MAP2K2/TNFRSF1A/FCER1G	0.138993683060174
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/353	99/9376	1.07316794002346	KRT19/KRT18/FCGR3A/CFB	0.144754528557463
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	7/353	180/9376	1.03292414227258	CCL2/CALR/HLA-C/TNFRSF1A/B2M/SRSF9/PPP1CA	0.0882162826691592
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/353	181/9376	1.02721737905561	ATP6V0B/TNFRSF1A/CD14/FCER1G/FCGR3A/ATP6V0C/CALM2	0.0731319636295233
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/353	128/9376	1.03753541076487	NME2/GUK1/APRT/AK1/HDDC2	0.0845706676894985
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/353	157/9376	1.0150664910413	ACTB/ACTG1/BMP5/ID1/CCND1/PPP1CA	0.0376545575247812
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/353	103/9376	1.03149151516818	CCL2/CALR/GNAI2/TNFRSF1A	0.063562292316365
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/353	76/9376	1.04845683614134	MAP2K2/CCND1/CALM2	0.0838914862767874
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/353	78/9376	1.02157332752234	EEF1A1/CYBA/FCGR3A	0.0378413986167085
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/353	134/9376	0.991078601327639	MYL6/MAP2K2/PRKG1/CALM2/PPP1CA	-0.0205731066052603
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/353	107/9376	0.992931084694607	PKM/LDHB/PGAM1/CALM2	-0.0145454023234898
Human Diseases	Substance dependence	hsa05034	Alcoholism	7/353	191/9376	0.973436364445367	GNG10/GNAI2/GNB2/GNG11/CALM2/PPP1CA/GNGT1	-0.0733604739953186
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/353	23/9376	1.15482202241655	FDPS	0.147034313887664
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	4/353	109/9376	0.974712165709385	SPP1/RAC1/MAP2K2/CD14	-0.0525233981949518
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/353	109/9376	0.974712165709385	CD36/TNFRSF1A/GFPT2/PPP1CA	-0.0525233981949518
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/353	82/9376	0.971740482277344	CALR/HLA-C/B2M	-0.0508355878775677
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/353	139/9376	0.955428291927365	KRT19/GNAI2/MAP2K2/KRT18/CALM2	-0.104712545683218
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/353	54/9376	0.983737278354842	LDHB/MDH2	-0.0237046240254242
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/353	26/9376	1.02157332752234	FADS2	0.021786903894177
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/353	87/9376	0.915893328123474	RAC1/MAP2K2/CCND1	-0.155884561355875
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/353	117/9376	0.908065180019854	ACTB/ACTG1/CDK2AP1/ZNHIT1	-0.197919429773958
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/353	59/9376	0.900369712392567	NME2/HDDC2	-0.151836734269913
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/353	59/9376	0.900369712392567	GNAI2/PRKG1	-0.151836734269913
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/353	59/9376	0.900369712392567	MAP2K2/CCND1	-0.151836734269913
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	7/353	205/9376	0.906957783458854	CALR/HLA-C/RAC1/B2M/SEM1/ISG15/CCND1	-0.266407314103856
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/353	28/9376	0.948603804127883	AKR1B1	-0.0538701458751263
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/353	60/9376	0.885363550519358	RAC1/MAP2K2	-0.176189946667512
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/353	120/9376	0.885363550519358	RAC1/MAP2K2/BEX3/CALM2	-0.249976503350967
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/353	91/9376	0.875634280733431	CD81/RAC1/MAP2K2	-0.235791388713613
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	8/353	238/9376	0.892803580355655	GNG10/EFNA5/RAC1/MAP2K2/GNB2/GNG11/CALM2/GNGT1	-0.331314691359042
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/353	122/9376	0.870849393953467	CD36/SCD/EEF2/CCND1	-0.283993976273405
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/353	122/9376	0.870849393953467	ACTB/ACTG1/MAP2K2/CCND1	-0.283993976273405
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/353	30/9376	0.885363550519358	MDH2	-0.124384990651098
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/353	30/9376	0.885363550519358	FOLR2	-0.124384990651098
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/353	93/9376	0.856803435986475	MMP14/MAP2K2/CALM2	-0.27449055701532
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/353	93/9376	0.856803435986475	ITGA3/ITGA2/CCND1	-0.27449055701532
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/353	31/9376	0.856803435986475	MDH2	-0.157950608560104
NA	NA	hsa04981	Folate transport and metabolism	1/353	31/9376	0.856803435986475	FOLR2	-0.157950608560104
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/353	156/9376	0.851311106268613	IFIT1/CD81/MAP2K2/TNFRSF1A/CCND1	-0.370401623113621
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/353	32/9376	0.830028328611898	AKR1B1	-0.190494583487397
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/353	32/9376	0.830028328611898	LDHB	-0.190494583487397
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/353	32/9376	0.830028328611898	GABARAP	-0.190494583487397
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/353	32/9376	0.830028328611898	TNFRSF1A	-0.190494583487397
Human Diseases	Immune disease	hsa05310	Asthma	1/353	32/9376	0.830028328611898	FCER1G	-0.190494583487397
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/353	65/9376	0.817258662017869	SPP1/MAP2K2	-0.292410408555244
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/353	157/9376	0.845888742534418	CD36/CALR/RAC1/MAP2K2/BSG	-0.385158773436113
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	7/353	216/9376	0.860770118560487	CD36/CCL2/CYBA/RAC1/TNFRSF1A/CD14/CALM2	-0.409457758150803
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	7/353	217/9376	0.856803435986475	CYP1B1/MGST1/GNAI2/MAP2K2/GSTM3/MGST3/CCND1	-0.422120016916149
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/353	33/9376	0.804875955017598	VAMP8	-0.222086468472217
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/353	100/9376	0.796827195467422	CXCL14/CCL2/TNFRSF1A	-0.404001258267902
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/353	101/9376	0.788937817294477	GNAI2/MAP2K2/CALM2	-0.421804943251428
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/353	69/9376	0.769881348277702	GNAI2/CALM2	-0.379462637869502
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/353	70/9376	0.758883043302307	CD36/TNFRSF1A	-0.400491000656001
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/353	36/9376	0.737802958766132	AKR1B1	-0.31174759449161
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/353	36/9376	0.737802958766132	GPI	-0.31174759449161
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/353	71/9376	0.748194549734669	MAP2K2/CCND1	-0.421243898994656
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/353	37/9376	0.717862338258939	GFPT2	-0.340102049676936
NA	NA	hsa04082	Neuroactive ligand signaling	6/353	199/9376	0.800831352228565	GNG10/GNAI2/GNB2/GRIA4/GNG11/GNGT1	-0.561687371081772
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/353	73/9376	0.72769606892002	PPIA/RAN	-0.461956777140128
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/353	73/9376	0.72769606892002	MAP2K2/CCND1	-0.461956777140128
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/353	73/9376	0.72769606892002	MAP2K2/CCND1	-0.461956777140128
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/353	138/9376	0.769881348277702	ANAPC11/RBX1/CALM2/PPP1CA	-0.538641607138713
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	4/353	138/9376	0.769881348277702	RPS6/MAP2K2/CALM2/PPP1CA	-0.538641607138713
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/353	39/9376	0.681048885014891	HLA-C	-0.39477556249152
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/353	108/9376	0.737802958766132	EEF1A1/SUMO2/RAN	-0.542056009983879
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/353	75/9376	0.708290840415486	PERP/CCND1	-0.501664521094369
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	4/353	142/9376	0.748194549734669	CYBA/RAC1/TNFRSF1A/FCGR3A	-0.598014721623812
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/353	77/9376	0.68989367572937	RAC1/CCND1	-0.540424929055696
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/353	77/9376	0.68989367572937	MAP2K2/CCND1	-0.540424929055696
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/353	41/9376	0.647826988184896	PGAM1	-0.446980267318366
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/353	41/9376	0.647826988184896	SEM1	-0.446980267318366
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/353	41/9376	0.647826988184896	GRIA4	-0.446980267318366
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/353	144/9376	0.737802958766132	TNFRSF1A/CD14/SCD/CCND1	-0.627131545574719
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/353	42/9376	0.632402536085256	CYP1B1	-0.472237820270729
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/353	43/9376	0.617695500362343	CD36	-0.496970393300612
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/353	80/9376	0.664022662889518	RPS6/MAP2K2	-0.59690392111921
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/353	115/9376	0.692893213449932	NACA/MMP14/GNAI2	-0.655400704719914
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/353	44/9376	0.603656966263199	GTF2H5	-0.521203969534689
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/353	44/9376	0.603656966263199	DYNLL1	-0.521203969534689
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/353	45/9376	0.590242367012905	HLA-C	-0.544962635723636
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/353	83/9376	0.640021843748933	PRDX1/PRDX5	-0.65153048047094
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/353	83/9376	0.640021843748933	POLR2L/IL33	-0.65153048047094
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/353	119/9376	0.669602685266741	CCL2/MMP14/TNFRSF1A	-0.717418167026145
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/353	47/9376	0.565125670544271	PKM	-0.591143157183302
NA	NA	hsa04081	Hormone signaling	6/353	219/9376	0.72769606892002	GNG10/GNAI2/PRKG1/GNB2/GNG11/GNGT1	-0.806486075761051
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/353	49/9376	0.542059316644505	GXYLT2	-0.635673038653542
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/353	49/9376	0.542059316644505	GNAI2	-0.635673038653542
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	4/353	160/9376	0.664022662889518	CDH2/HLA-C/CADM3/CD99	-0.847805547793895
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/353	226/9376	0.705156810148161	GNAI2/RAC1/MAP2K2/GRIA4/CALM2/PPP1CA	-0.887426280414279
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/353	51/9376	0.520802088540799	ENPP2	-0.67869257281359
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/353	52/9376	0.510786663761168	CYP1B1	-0.699674972257969
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/353	93/9376	0.57120229065765	PRKG1/CALM2	-0.821953535652979
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/353	94/9376	0.565125670544271	CCL2/S100A9	-0.838116574064938
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/353	54/9376	0.491868639177421	HLA-C	-0.740654801000832
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/353	133/9376	0.599118192080768	GABARAP/MAP2K2/CCND1	-0.920943961276724
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/353	56/9376	0.474301902063942	CCND1	-0.780404877774048
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/353	99/9376	0.536583970011732	MAP2K2/CCND1	-0.916816421583148
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/353	99/9376	0.536583970011732	CALM2/PPP1CA	-0.916816421583148
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/353	99/9376	0.536583970011732	RAC1/MAP2K2	-0.916816421583148
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/353	102/9376	0.520802088540799	RAC1/RAB27B	-0.962451755217416
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/353	178/9376	0.596874303720915	BAMBI/RAC1/RBX1/CCND1	-1.07399260947537
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/353	105/9376	0.505922028868205	TNFRSF1A/CD14	-1.00698815520968
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/353	105/9376	0.505922028868205	FCER1G/CALM2	-1.00698815520968
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/353	63/9376	0.421601690723504	PLOD2	-0.911066337153183
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/353	65/9376	0.408629331008934	AKR1B1	-0.946271603550227
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/353	66/9376	0.402437977508799	CYP1B1	-0.963557481872867
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/353	110/9376	0.482925573010559	GNAI2/ANAPC11	-1.07894862576712
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	4/353	187/9376	0.568147732953599	CCL2/CYBA/GABARAP/TXN	-1.17982988745497
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/353	68/9376	0.390601566405599	ALDH1A3	-0.997528045748804
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	2/353	112/9376	0.474301902063942	GNAI2/TNFRSF1A	-1.10698989378412
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/353	154/9376	0.517420256797027	NME2/NQO1/AK1	-1.19430266573804
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/353	154/9376	0.517420256797027	GNAI2/CALM2/PPP1CA	-1.19430266573804
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/353	155/9376	0.514082061591885	GNAI2/MAP2K2/CCND1	-1.20652765890137
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/353	72/9376	0.368901479383066	ISG15	-1.06322718355587
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	3/353	158/9376	0.504321009789508	ANAPC11/RBX1/CCND1	-1.24281994745955
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/353	122/9376	0.435424696976733	GNAI2/MAP2K2	-1.24146521738791
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/353	201/9376	0.528575254041408	PLAT/CD14/NUPR1/HMGA2	-1.33630280543502
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/353	78/9376	0.340524442507445	TPI1	-1.15677460619898
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/353	78/9376	0.340524442507445	ENO1	-1.15677460619898
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	4/353	205/9376	0.518261590547917	PKM/HLA-C/RAC1/CCND1	-1.37935918267853
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/353	86/9376	0.308847750181171	MAP2K2	-1.27354004937599
Human Diseases	Infectious disease: viral	hsa05162	Measles	2/353	136/9376	0.390601566405599	RACK1/CCND1	-1.4158991282164
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/353	90/9376	0.295121183506453	MAP2K2	-1.32898134972814
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	6/353	298/9376	0.534783352662699	CXCL14/CCL2/BMP5/TNFRSF1A/TNFRSF12A/IL33	-1.61423144182455
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/353	144/9376	0.368901479383066	MAP2K2/ID1	-1.5094822915694
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/353	98/9376	0.271029658322252	CALM2	-1.43480613596611
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/353	98/9376	0.271029658322252	CALM2	-1.43480613596611
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/353	148/9376	0.358931169129469	MAP2K2/CCND1	-1.55481685063266
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	2/353	149/9376	0.356522235108466	MAP2K2/FCER1G	-1.5660078356063
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/353	150/9376	0.354145420207743	MAP2K2/CCND1	-1.57714331745304
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/353	103/9376	0.257872878792046	PPP1CA	-1.49790509482312
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	4/353	254/9376	0.41828199237135	SLC25A6/SLC25A5/ASPH/CALM2	-1.85901050780064
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	5/353	300/9376	0.442681775259679	EFNA5/RAC1/MAP2K2/TNFRSF1A/CD14	-1.94050220702417
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/353	122/9376	0.217712348488367	MAP2K2	-1.72020083794517
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/353	183/9376	0.290283131317822	NOP10/RAN	-1.91769508320944
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	5/353	323/9376	0.411159543584841	CYP1B1/EFNA5/MAP2K2/CCND1/HMGA2	-2.13010079197674
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/353	143/9376	0.185740605004061	FCGR3A	-1.94069323225613
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/353	163/9376	0.162950346721354	MAP2K2	-2.13226903293629
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	1/353	168/9376	0.158100634021314	CCND1	-2.1778586048137
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/353	243/9376	0.109304142039427	SRSF9	-2.78242427020421
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3/353	370/9376	0.215358701477682	TSPO/SPX/GRIA4	-3.04581531326511
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/353	449/9376	0.118311387597242	PRKG1/CALM2	-3.78689398357418