category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	49/868	138/9376	3.8354371201496	MT-ATP6/MT-CO3/MT-ND3/MT-ND1/MT-CYB/MT-CO2/MT-CO1/MT-ND2/MT-ND4/MT-ND5/ATP5PO/ATP5F1B/ATP5F1C/NDUFB4/ATP5PD/NDUFA12/ATP6V1G1/NDUFS6/NDUFV2/COX7B/ATP6V0B/NDUFB9/COX8A/ATP5PF/ATP6V1E1/NDUFA2/NDUFA1/UQCRFS1/NDUFB5/SDHC/NDUFB3/NDUFA5/ATP6V1A/ATP6AP1/NDUFS1/ATP6V1C1/ATP5PB/ATP5MG/NDUFB6/ATP5F1A/ATP5MF/ATP6V0D1/MT-ND4L/ATP5MC3/ATP6V0A1/ATP6V0C/UQCR10/COX11/UQCRB	10.717718472875
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	73/868	308/9376	2.5601771500389	MT-ATP6/MT-CO3/MT-ND3/MT-ND1/MT-CYB/MT-CO2/MT-CO1/MT-ND2/MT-ND4/MT-ND5/ATP5PO/ATP5F1B/KIF5B/ATP5F1C/NDUFB4/ATP5PD/NDUFA12/CLTB/POLR2F/NDUFS6/NDUFV2/COX7B/NDUFB9/COX8A/ATP5PF/NDUFA2/NDUFA1/PSMA4/PSMA1/PSMC1/UQCRFS1/NDUFB5/CLTC/CLTA/TGM2/SDHC/NDUFB3/ACTR10/POLR2K/NDUFA5/BAX/ADRM1/POLR2E/TUBA1C/PSMD12/NDUFS1/PSMC6/ATP5PB/NDUFB6/ATP5F1A/SLC25A5/AP2S1/PSMA3/MTOR/WIPI2/MT-ND4L/ATP5MC3/PSMD3/CREB3/CREB3L2/TUBB2A/TP53/DCTN6/DCTN5/UQCR10/ATG13/MAPK9/ITPR1/WIPI1/DCTN4/SP1/ATG2A/UQCRB	8.89252870462302
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	80/868	368/9376	2.34822680825486	MT-ATP6/MT-CO3/MT-ND3/MT-ND1/MT-CYB/MT-CO2/MT-CO1/MT-ND2/MT-ND4/MT-ND5/ATP5PO/ATP5F1B/KIF5B/ATP5F1C/NDUFB4/ATP5PD/NDUFA12/NDUFS6/NDUFV2/RANBP2/COX7B/NDUFB9/ATF4/COX8A/ATP5PF/NDUFA2/NDUFA1/PSMA4/RAB1A/PSMA1/PSMC1/UQCRFS1/NDUFB5/ACTB/SDHC/NDUFB3/ACTR10/NDUFA5/BAX/ADRM1/TUBA1C/SRSF3/PSMD12/NDUFS1/PSMC6/TNFRSF1A/ATP5PB/HNRNPA1/NDUFB6/ATP5F1A/NUP214/PSMA3/BAD/MTOR/PINK1/WIPI2/TANK/MT-ND4L/POM121/ATP5MC3/PSMD3/TUBB2A/TP53/DCTN6/DCTN5/UQCR10/BCL2L1/ATG13/NUP50/NXF1/WIPI1/DCTN4/POM121C/C9orf72/NUP155/NUP62/ATG2A/NUP37/CAT/UQCRB	8.4276101825023
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	55/868	205/9376	2.89805552433405	MT-ATP6/MT-CO3/MT-ND3/MT-ND1/MT-CYB/MT-CO2/MT-CO1/MT-ND2/SLC2A1/MT-ND4/MT-ND5/COL3A1/ATP5PO/ATP5F1B/ATP5F1C/NDUFB4/ATP5PD/NDUFA12/NDUFS6/CYBB/NDUFV2/COX7B/NDUFB9/COX8A/ATP5PF/NDUFA2/NDUFA1/UQCRFS1/NDUFB5/SDHC/NDUFB3/TGFB1/NDUFA5/NDUFS1/PARP1/ATP5PB/NDUFB6/ATP5F1A/SLC25A5/MPC2/CTSD/PPP1CA/MTOR/MT-ND4L/ATP5MC3/GFPT1/PTEN/UQCR10/MAPK9/COL1A1/TGFBR1/SP1/PDK4/AKT2/UQCRB	8.77625547126687
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	63/868	275/9376	2.47460410557185	MT-ATP6/MT-CO3/MT-ND3/MT-ND1/MT-CYB/MT-CO2/MT-CO1/C1QA/MT-ND2/MT-ND4/MT-ND5/C1QB/C1QC/C7/ATP5PO/ATP5F1B/KIF5B/ATP5F1C/NDUFB4/ATP5PD/NDUFA12/NDUFS6/CYBB/NDUFV2/COX7B/NDUFB9/ATF4/COX8A/ATP5PF/NDUFA2/NDUFA1/PSMA4/PSMA1/PSMC1/UQCRFS1/NDUFB5/SDHC/NDUFB3/NDUFA5/BAX/ADRM1/TUBA1C/PSMD12/NDUFS1/PSMC6/ATP5PB/NDUFB6/ATP5F1A/SLC25A5/PSMA3/BAD/ATF6B/MT-ND4L/ATP5MC3/ITPR2/PSMD3/CREB3/CREB3L2/TUBB2A/UQCR10/MAPK9/ITPR1/UQCRB	7.92736744115364
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	79/868	388/9376	2.19934438690674	MT-ATP6/MT-CO3/MT-ND3/MT-ND1/MT-CYB/MT-CO2/MT-CO1/MT-ND2/MT-ND4/MT-ND5/ATP5PO/ATP5F1B/KIF5B/ATP5F1C/NDUFB4/ATP5PD/NDUFA12/NDUFS6/CYBB/NDUFV2/COX7B/NDUFB9/ATF4/COX8A/APOE/ATP5PF/NDUFA2/NDUFA1/PSMA4/PSMA1/PSMC1/UQCRFS1/NDUFB5/SDHC/NDUFB3/NDUFA5/ADRM1/TUBA1C/PSMD12/NDUFS1/PSMC6/TNFRSF1A/MAP2K2/ATP5PB/NDUFB6/ATP5F1A/SLC25A5/APH1A/PSMA3/BAD/MTOR/WIPI2/MT-ND4L/ATP5MC3/LRP6/ITPR2/WNT2/MAP2K1/PSMD3/TUBB2A/SLC39A13/UQCR10/ATG13/SLC39A11/MAPK9/ITPR1/SLC39A9/CALM3/WIPI1/NCSTN/DVL3/AKT2/IDE/FZD4/CHUK/DKK1/ATG2A/APBB1/UQCRB	7.70654995672342
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	61/868	268/9376	2.45862851640415	MT-ATP6/MT-CO3/MT-ND3/MT-ND1/MT-CYB/MT-CO2/MT-CO1/MT-ND2/MT-ND4/MT-ND5/ATP5PO/ATP5F1B/KIF5B/ATP5F1C/NDUFB4/ATP5PD/NDUFA12/NDUFS6/NDUFV2/COX7B/NDUFB9/ATF4/COX8A/ATP5PF/NDUFA2/NDUFA1/PSMA4/PSMA1/PSMC1/UQCRFS1/NDUFB5/SDHC/NDUFB3/NDUFA5/BAX/ADRM1/TUBA1C/PSMD12/NDUFS1/PSMC6/ATP5PB/NDUFB6/ATP5F1A/SLC25A5/PSMA3/PINK1/MT-ND4L/ATP5MC3/ITPR2/PSMD3/TUBB2A/TP53/SLC39A13/UQCR10/BCL2L1/SLC39A11/MAPK9/ITPR1/SLC39A9/CALM3/UQCRB	7.73806451106451
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	55/868	235/9376	2.52809098931268	MT-ATP6/MT-CO3/MT-ND3/MT-ND1/MT-CYB/MT-CO2/MT-CO1/MT-ND2/MT-ND4/MT-ND5/ATP5PO/ATP5F1B/ATP5F1C/NDUFB4/ATP5PD/RHEB/NDUFA12/COX16/NDUFS6/NDUFV2/COX7B/NDUFB9/COX8A/ATP5PF/NDUFA2/NDUFA1/UQCRFS1/NDUFB5/ACTB/SDHC/NDUFB3/NDUFA5/NDUFS1/GRB2/RPTOR/ATP5PB/ATP5MG/NDUFB6/ATP5F1A/SMARCB1/ARID1A/ATP5MF/MTOR/MT-ND4L/ATP5MC3/CREB3/CREB3L2/UQCR10/ACTL6A/TSC2/COX11/COA6/TSC1/SMARCD2/UQCRB	7.57736227894396
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	52/868	227/9376	2.47443106843419	MT-ATP6/MT-CO3/MT-ND3/MT-ND1/MT-CYB/MT-CO2/MT-CO1/MT-ND2/MT-ND4/MT-ND5/ATP5PO/ATP5F1B/ATP5F1C/NDUFB4/ATP5PD/NDUFA12/NDUFS6/NDUFV2/COX7B/NDUFB9/COX8A/ATP5PF/NDUFA2/NDUFA1/HGF/UQCRFS1/NDUFB5/SDHC/NDUFB3/NDUFA5/NDUFS1/GRB2/MAP2K2/ATP5PB/NDUFB6/ATP5F1A/SLC25A5/BAD/FOXO3/MT-ND4L/ATP5MC3/FOS/MAP2K1/PTEN/UQCR10/MAPK9/PDPK1/GSTA4/AKT2/CHUK/CAT/UQCRB	7.18261103647143
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	51/868	250/9376	2.20357603686636	LAMTOR5/BLOC1S1/ATP6V1G1/CLTB/ATP6V0B/LGMN/ATP6V1E1/TPP1/VPS29/CTSC/LAMTOR1/CLTC/GNPTAB/CLTA/CTBS/ATP6V1A/HEXA/ATP6AP1/HYAL2/ATP6V1C1/RPTOR/M6PR/CLN5/CTSD/LIPA/AP2S1/FUCA2/DMXL1/ARL8A/ATP6V0D1/MTOR/NEU1/AP3D1/HEXB/ATP6V0A1/CLN3/ATP6V0C/CTSO/AP1M1/PPT1/CD164/ACP2/VAMP7/GAA/CLCN7/BLOC1S5/LITAF/AP3M1/PSAP/AP5M1/GLB1	6.16077097999041
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	80/868	480/9376	1.80030721966206	MT-ATP6/MT-CO3/MT-ND3/MT-ND1/MT-CYB/MT-CO2/MT-CO1/MT-ND2/MT-ND4/MT-ND5/ATP5PO/ATP5F1B/KIF5B/ATP5F1C/NDUFB4/ATP5PD/NDUFA12/NDUFS6/CYBB/NDUFV2/COX7B/NDUFB9/ATF4/COX8A/ATP5PF/NDUFA2/NDUFA1/PSMA4/RAB1A/PSMA1/PSMC1/UQCRFS1/NDUFB5/SDHC/NDUFB3/ACTR10/NDUFA5/BAX/ADRM1/TUBA1C/PSMD12/NDUFS1/PSMC6/TNFRSF1A/MAP2K2/ATP5PB/NDUFB6/ATP5F1A/SLC25A5/PSMA3/BAD/MTOR/PINK1/WIPI2/TANK/MT-ND4L/ATP5MC3/LRP6/ITPR2/WNT2/MAP2K1/PSMD3/TUBB2A/DCTN6/DCTN5/UQCR10/BCL2L1/ATG13/MAPK9/ITPR1/CALM3/WIPI1/DCTN4/DVL3/C9orf72/FZD4/DKK1/ATG2A/CAT/UQCRB	5.74925705042865
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	35/868	157/9376	2.40805424286008	MT-CO3/MT-CYB/MT-CO2/MT-CO1/NDUFB4/NDUFA12/NDUFS6/NDUFV2/COX7B/NDUFB9/ATF4/COX8A/NDUFA2/NDUFA1/UQCRFS1/NDUFB5/SDHC/NDUFB3/TGFB1/NDUFA5/BAX/MAP3K11/NDUFS1/TNFRSF1A/NDUFB6/ADIPOR2/SOCS3/GSK3A/FOS/UQCR10/MAPK9/ADIPOR1/AKT2/SREBF1/UQCRB	5.68275672337454
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	48/868	250/9376	2.07395391705069	DAB2/KIF5B/CAPZB/ARPC5/SH3GLB1/CLTB/CAPZA1/CAPZA2/IST1/WASHC4/CHMP5/VPS29/ACAP2/RAB10/ARF1/CLTC/CLTA/ACTR2/FOLR2/VPS4B/DNM2/VPS4A/ARF4/RHOA/ARF6/AP2S1/MVB12A/SNX5/CHMP1A/RAB5B/VPS25/VPS37A/SNX3/WWP1/WASHC3/WASHC1/ARPC3/SH3KBP1/SNX6/ARPC1B/SH3GLB2/TFRC/TGFBR1/CYTH1/WASHC5/GIT2/GRK2/RAB11FIP2	5.49727140068309
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	37/868	174/9376	2.29694369405159	RAD23A/OSTC/ATF4/CANX/ERP29/SAR1A/HERPUD1/SSR3/SEC23A/RPN2/SIL1/TRAM1/BAX/RPN1/SSR1/P4HB/UGGT2/NSFL1C/SEC24D/DNAJB11/ATF6B/SAR1B/CKAP4/DDOST/PLAA/AMFR/DNAJB12/STT3A/DNAJA2/SEC24C/PDIA4/MAPK9/MAN1B1/MOGS/MAN1C1/UBXN8/DNAJB2	5.51551908561027
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	23/868	108/9376	2.30039255845707	SRRM1/IPO7/RANBP2/THOC2/KPNA6/MAGOH/NUP214/CSE1L/IPO9/POM121/TMEM33/PHAX/XPO7/IPO8/DDX19A/NUP42/NUP50/NXF1/POM121C/NUP155/NUP62/NUP37/THOC5	4.34135300704828
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	31/868	169/9376	1.98140321217244	SH3GLB1/RHEB/RAB1A/MAP2K2/RPTOR/ATG7/CTSD/NBR1/BAD/MTOR/WIPI2/TANK/MAP2K1/CFLAR/PTEN/TAX1BP1/BCL2L1/ATG13/TSC2/MAPK9/ITPR1/MTMR14/WIPI1/PDPK1/TSC1/C9orf72/AKT2/ATG4C/ATG16L2/YKT6/ATG2A	4.11209856571304
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	38/868	227/9376	1.80823808847114	CCL3/RHEB/GNB2/ATF4/GNGT1/BAX/CRK/GNA13/GRB2/IL1R1/TNFRSF1A/RHOA/MAP2K2/CCL4L2/CDK6/RB1/IL10RB/GNG10/CCL4/ATF6B/MTOR/GNA11/ITPR2/MAP2K1/CREB3/CREB3L2/TP53/TSC2/ITPR1/CALM3/GNG7/ARHGEF1/TRADD/TSC1/SP1/CCR1/AKT2/CHUK	3.93728804189838
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	40/868	248/9376	1.74223279322135	CD14/KIF5B/ARPC5/PKN1/CYFIP1/ARF1/ACTB/ACTR2/ACTR10/RHOG/BAX/TUBA1C/DNM2/TNFRSF1A/RHOA/ARF6/MAP2K2/LY96/M6PR/PODXL/CSE1L/ARL8A/RAB5B/FOS/EXOC7/MAP2K1/TUBB2A/BIRC2/DCTN6/NAIP/DCTN5/ARPC3/MAPK9/ARPC1B/TRADD/CYTH1/DCTN4/AKT2/IRAK1/CHUK	3.78364100316756
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	28/868	158/9376	1.91425071457738	LAMTOR5/RHEB/ATP6V1G1/ATP6V1E1/LAMTOR1/ATP6V1A/MAPKAP1/GRB2/ATP6V1C1/TNFRSF1A/RHOA/MAP2K2/RPTOR/SLC3A2/MTOR/LRP6/WNT2/MAP2K1/LPIN1/PTEN/TSC2/PDPK1/DVL3/TSC1/AKT2/FZD4/TBC1D7/CHUK	3.70175149292559
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	13/868	51/9376	2.75341104183609	ATP6V1G1/KDELR2/ATP6V0B/ATP6V1E1/ARF1/ACTB/ATP6V1A/ATP6AP1/ATP6V1C1/ATP6V0D1/ATP6V0A1/ATP6V0C/PDIA4	4.01029356245539
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	25/868	137/9376	1.97113929160079	ATF4/CTSC/ACTB/BAX/TUBA1C/PARP1/TNFRSF1A/MAP2K2/CTSD/BAD/FOS/ITPR2/MAP2K1/CFLAR/ATM/TP53/BIRC2/BCL2L1/MAPK9/ITPR1/CTSO/TRADD/PDPK1/AKT2/CHUK	3.65730421003788
Genetic Information Processing	Transcription	hsa03040	Spliceosome	38/868	243/9376	1.68917714437428	SF3B6/PCBP1/SYF2/SF3B5/SNRPF/LSM7/LSM3/RBM17/SNRPG/SRSF5/U2SURP/THOC2/TRA2B/SNRPE/SRSF9/LSM8/SNRPC/CWC15/PUF60/HNRNPK/SNRPD3/SRSF3/SRSF6/MAGOH/HNRNPA1/SRSF1/PRPF8/LSM5/LSM4/SNRNP40/CCDC12/LSM6/PRPF31/PPIH/SF3B4/PRPF19/SART1/THOC5	3.47663449077472
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	48/868	333/9376	1.55702246024827	SPP1/FN1/LAMA2/RHEB/ATP6V1G1/PPP2R2A/ATP6V0B/PPP2R1A/ATP6V1E1/RBPJ/CHD4/PSMC1/BAX/ATP6V1A/ATP6AP1/CCND2/GRB2/ATP6V1C1/TNFRSF1A/MAP2K2/COL6A2/CDK6/RB1/BAD/ATP6V0D1/MTOR/MFNG/WNT2/MAP2K1/STAT2/CREB3/ATP6V0A1/CREB3L2/ATM/TP53/ATP6V0C/PTEN/TSC2/COL1A1/ITGA3/TADA3/TRADD/DVL3/TSC1/AKT2/FZD4/CDKN1B/CHUK	3.30575237515671
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	18/868	90/9376	2.16036866359447	RHEB/ATF4/BAX/RPTOR/ADIPOR2/ATF6B/MTOR/FOXO3/KL/CREB3/CREB3L2/TP53/ATG13/TSC2/ADIPOR1/TSC1/AKT2/CAT	3.5329270271947
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	9/868	31/9376	3.13601902779842	SPCS2/SRP9/SPCS1/SRP19/SPCS3/BAG6/SRPRA/OXA1L/SGTA	3.80476704515833
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	16/868	77/9376	2.24453887126698	TGFB1/BAX/CRK/GRB2/MAP2K2/CDK6/RB1/BAD/MAP2K1/TP53/CTBP1/BCL2L1/TGFBR1/AKT2/CDKN1B/CHUK	3.50241387399202
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	11/868	44/9376	2.70046082949309	OSTC/B4GALT1/RPN2/RPN1/HEXA/MGAT1/DDOST/HEXB/STT3A/MAN1B1/MAN1C1	3.6110821265664
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	16/868	78/9376	2.21576273189176	LSM7/LSM3/LSM8/C1D/CNOT7/LSM5/PABPC4/LSM4/DCP2/EXOSC6/LSM6/EXOSC8/EXOSC7/BTG2/TOB1/EXOSC3	3.44376190022779
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	38/868	253/9376	1.62241124933972	CD14/ARPC5/ACTN4/ARF1/ACTB/ACTR2/BAX/CRK/IL1R1/TNFRSF1A/RHOA/ARF6/RPTOR/FNBP1/GSK3A/MTOR/FOXO3/WIPI2/RPS6KA5/ITPR2/ARHGEF2/ATM/TP53/TECPR1/NAIP/BCL2L1/ARPC3/UBE2V2/MAPK9/ITPR1/CD44/ARPC1B/HCLS1/WIPI1/TRADD/CYTH1/AKT2/CHUK	3.20553569083165
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	29/868	180/9376	1.74029697900666	RHEB/SRSF5/SRSF9/BAX/SRSF3/SRSF6/TNFRSF1A/SRSF1/PPP1CA/SOCS3/BAD/MTOR/STAT2/CD74/TP53/BIRC2/HLA-DRA/BCL2L1/TSC2/IFNGR1/NXF1/TRADD/TSC1/EIF2B4/JAK2/AKT2/IRAK1/IFIH1/CHUK	3.20312958368722
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	29/868	181/9376	1.73068207857016	FCGR2B/CD14/FCGR3A/FCER1G/ATP6V0B/TGFB1/BAX/CR1/ATP6AP1/TNFRSF1A/RHOA/CTSD/IL10RB/FCGR1A/BAD/RAB5B/ATP6V0D1/ATP6V0A1/CD74/HLA-DRA/ATP6V0C/MAPK9/CALM3/IFNGR1/NFYB/TRADD/JAK2/AKT2/IRAK1	3.17046991423461
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	25/868	149/9376	1.81238981845174	MT-ND3/MT-ND1/MT-ND2/MT-ND4/MT-ND5/NDUFB4/NDUFA12/NDUFS6/NDUFV2/GNB2/NDUFB9/NDUFA2/NDUFA1/GNGT1/NDUFB5/NDUFB3/NDUFA5/NDUFS1/NDUFB6/GNG10/MT-ND4L/ITPR2/MAPK9/ITPR1/GNG7	3.19270730474245
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	15/868	73/9376	2.2195568461587	KIF5B/HGF/BAX/GRB2/MAP2K2/CDK6/RB1/BAD/FOXO3/MAP2K1/TP53/RXRB/PDPK1/STK4/AKT2	3.3410557945258
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	34/868	224/9376	1.6395655036208	SLC2A1/TSPO/ATF4/CANX/TGFB1/BAX/CCND2/NRP1/IL1R1/TNFRSF1A/MAP2K2/SLC25A5/RB1/ATF6B/FOS/MAP2K1/CREB3/CREB3L2/ATM/TP53/ICAM1/HLA-DRA/PTEN/BCL2L1/MAPK9/RANBP3/ANAPC13/MAD1L1/NFYB/TGFBR1/AKT2/CHUK/ANAPC15/SRF	3.09444518987081
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	24/868	144/9376	1.80030721966206	PSMA4/RBPJ/PSMA1/PSMC1/ADRM1/PSMD12/PSMC6/NOP56/SLC25A5/AFG3L2/PSMA3/MTOR/WIPI2/ITPR2/PSMD3/GTF2B/ATG13/MAPK9/ITPR1/WIPI1/SP1/AKT2/ATG2A/CIC	3.09116254883102
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	19/868	105/9376	1.95461926706166	TOMM20/ATF4/BNIP3L/NBR1/RAB5B/PINK1/FOXO3/AMFR/TP53/TOMM70/MTX1/SAMM50/TAX1BP1/BCL2L1/RHOT1/MAPK9/MUL1/SP1/TBC1D17	3.14190691901511
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	23/868	138/9376	1.80030721966206	RHEB/PRKAR1A/RAPGEF1/CRK/GRB2/MAP2K2/RPTOR/PPP1CA/SOCS3/BAD/MTOR/TRIP10/PRKAR2A/EXOC7/MAP2K1/PPP1R3B/TSC2/MAPK9/CALM3/PDPK1/TSC1/AKT2/SREBF1	3.02509528819835
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	25/868	155/9376	1.74223279322135	FCGR2B/CD14/FCGR3A/ATP6V1G1/CYBB/ATP6V0B/ATP6V1E1/CANX/ACTB/TUBA1C/ATP6V1A/ATP6AP1/ATP6V1C1/M6PR/STX18/FCGR1A/RAB5B/ATP6V0D1/ATP6V0A1/TUBB2A/SEC22B/HLA-DRA/ATP6V0C/SCARB1/TFRC	2.976108338144
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	14/868	70/9376	2.16036866359447	SLC2A1/EGLN2/RAPGEF1/HGF/TGFB1/CRK/GRB2/MAP2K2/EPAS1/BAD/MAP2K1/PDGFB/PRCC/AKT2	3.11239886310569
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	16/868	87/9376	1.98654589755813	TGFB1/BAX/GRB2/RHOA/MAP2K2/BAD/MTOR/FOS/MAP2K1/MSH3/TP53/MSH6/MAPK9/AREG/TGFBR1/AKT2	2.95273315096517
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	15/868	80/9376	2.02534562211982	HGF/BAX/GRB2/MAP2K2/BAD/MTOR/FOXO3/KDR/MAP2K1/PDGFB/PTEN/BCL2L1/JAK2/AKT2/AXL	2.94170404458887
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	20/868	119/9376	1.81543585176006	ATF4/TNFRSF1A/SOCS3/ATF6B/FOS/RPS6KA5/MAP2K1/CFLAR/CREB3/CREB3L2/BIRC2/ICAM1/MAP3K8/MAPK9/MMP14/TRADD/RHBDF2/AKT2/CHUK/BAG4	2.85930122872315
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	48/868	362/9376	1.43228861674771	SPP1/FN1/LAMA2/RHEB/PRLR/PPP2R2A/CSH1/PKN1/GNB2/ATF4/PPP2R1A/FLT1/PKN2/IGF2/HGF/GNGT1/CCND2/GRB2/OSMR/MAP2K2/COL6A2/RPTOR/CDK6/GNG10/BAD/ATF6B/MTOR/FOXO3/KDR/MAP2K1/CREB3/CREB3L2/TP53/PDGFB/PTEN/IL4R/BCL2L1/TSC2/COL1A1/GNG7/ITGA3/AREG/PDPK1/TSC1/JAK2/AKT2/CDKN1B/CHUK	2.67917491447011
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	26/868	170/9376	1.65204662510165	IGF2/HGF/ACTB/TGFB1/BAX/GRB2/MAP2K2/SMARCB1/CDK6/ARID1A/RB1/BAD/MTOR/LRP6/WNT2/MAP2K1/TP53/PTEN/BCL2L1/ACTL6A/TGFBR1/DVL3/GSTA4/AKT2/FZD4/SMARCD2	2.74030805306355
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	8/868	32/9376	2.70046082949309	RPTOR/ATG7/MTOR/WIPI2/ATG13/WIPI1/ATG4C/ATG2A	3.0775631044117
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	22/868	138/9376	1.72203299272023	FN1/ARPC5/PKN1/PKN2/ACTB/ACTR2/RHOG/CRK/RHOA/ARF6/MAP2K2/FOS/MAP2K1/ARPC3/MAPK9/ARPC1B/ARHGEF1/VAV2/GIT2/AKT2/IRAK1/CHUK	2.72922516571079
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	10/868	46/9376	2.34822680825486	PSMA4/PSMA1/PSMC1/ADRM1/PSMD12/PSMC6/PSMA3/PSMD3/POMP/PSMB10	2.92774206490612
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	17/868	99/9376	1.85486198389424	RHEB/GRB2/MAP2K2/SLC44A2/MTOR/FOS/MAP2K1/PDGFB/SLC22A3/TSC2/MAPK9/SLC44A4/PDPK1/TSC1/SP1/AKT2/DGKZ	2.73112503600918
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	29/868	200/9376	1.56626728110599	ARPC5/MYO1C/CYFIP1/RAB1A/ARF1/ACTB/ACTR2/BAX/TUBA1C/GNA13/IL1R1/TNFRSF1A/RHOA/ARF6/SEC24D/FOS/ARHGEF2/TUBB2A/NAIP/ARPC3/SEC24C/MAPK9/ARPC1B/HCLS1/ARHGEF1/TRADD/CYTH1/IRAK1/CHUK	2.58548203462154
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	20/868	125/9376	1.72829493087558	FCER1G/PPP2R2A/ORMDL1/PPP2R1A/BAX/GNA13/TNFRSF1A/RHOA/MAP2K2/DEGS1/CTSD/SPTSSA/MAP2K1/TP53/PTEN/MAPK9/TRADD/PDPK1/SGPP1/AKT2	2.61818128018245
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/868	78/9376	1.93879239040529	FN1/ARPC5/CLTB/ACTB/CLTC/CLTA/ACTR2/RHOG/DNM2/CRK/RHOA/ARPC3/ARPC1B/HCLS1	2.65921744555445
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/868	28/9376	2.70046082949309	ATP6V1G1/ATP6V1E1/ATP6V1A/ATP6V1C1/ATP6V0D1/ATP6V0A1/ATP6V0C	2.87818069768633
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	13/868	71/9376	1.97780229765691	PRLR/CCND2/GRB2/MAP2K2/CGA/SOCS3/FOXO3/FOS/MAP2K1/MAPK9/JAK2/AKT2/GALT	2.64151936737015
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13/868	71/9376	1.97780229765691	JAM2/ATP6V1G1/ATP6V0B/ATP6V1E1/ATP6V1A/ATP6AP1/ATP6V1C1/ATP6V0D1/ATP6V0A1/ATP6V0C/MAPK9/CSK/CHUK	2.64151936737015
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/868	42/9376	2.31468071099407	FTL/PCBP1/CYBB/ATG7/SLC3A2/TP53/GPX4/GCLM/TFRC	2.72736208082502
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	17/868	103/9376	1.78282850879155	C1QA/C1QB/C1QC/CCL3/PPP2R2A/PPP2R1A/TGFB1/TNFRSF1A/GNA11/FOS/CFLAR/MAPK9/IFNGR1/TGFBR1/AKT2/IRAK1/CHUK	2.5515664078789
Genetic Information Processing	Translation	hsa03010	Ribosome	31/868	222/9376	1.50836550836551	RPL27A/MRPL33/MRPL14/RPL23/MRPL27/RPLP1/MRPL54/MRPS16/RPL4/MRPS34/MRPL40/MRPL20/RPL36AL/MRPS28/MRPL36/MRPS18B/MRPL17/RPS24/MRPS23/MRPS33/MRPL24/RPL26L1/MRPL2/MRPL3/MRPS22/MRPL12/MRPL4/RPL38/MRPL32/RPS10/MRPL49	2.44838026464718
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	16/868	95/9376	1.81925782197429	CCL3/ATP6V1G1/ATP6V0B/ATP6V1E1/FLT1/TGFB1/ATP6V1A/ATP6AP1/ATP6V1C1/MMP1/ATP6V0D1/FOS/ATP6V0A1/ICAM1/HLA-DRA/ATP6V0C	2.56340232001987
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	19/868	120/9376	1.71029185867896	ATF4/RAPGEF1/BAX/CRK/GRB2/RHOA/MAP2K2/BAD/FOXO3/RPS6KA5/MAP2K1/TP53/MAPK9/PRDM4/CALM3/PDPK1/AKT2/IRAK1/BEX3	2.50119497254872
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	19/868	122/9376	1.6822542872252	IGFBP3/CSH1/ATF4/CRK/GRB2/MAP2K2/SOCS3/ATF6B/MTOR/GNA11/FOS/ITPR2/MAP2K1/CREB3/CREB3L2/MAPK9/ITPR1/JAK2/AKT2	2.42266408627072
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	17/868	106/9376	1.73237109816538	ATF4/FOLR2/GRB2/MAP2K2/RB1/BAD/MTOR/MAP2K1/CREB3/CREB3L2/TP53/PDGFB/PTEN/PDPK1/AKT2/CDKN1B/CHUK	2.42201050776657
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	9/868	44/9376	2.20946795140344	GTF2I/TAF7/GTF2A2/GTF2A1/GTF2H5/GTF2B/TAF9/GTF2H3/TAF6	2.56841441226834
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	23/868	157/9376	1.58243564530805	IGFBP3/RHEB/ZFP36L1/TGFB1/CCND2/MAP2K2/SLC25A5/CDK6/RB1/PPP1CA/MTOR/FOXO3/ITPR2/MAP2K1/ATM/TP53/PTEN/TSC2/ITPR1/CALM3/TGFBR1/TSC1/AKT2	2.35064813453797
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	28/868	203/9376	1.4899094231686	SPP1/FN1/LAMA2/ACTN4/RAPGEF1/FLT1/HGF/ACTB/CRK/CCND2/GRB2/RHOA/COL6A2/PPP1CA/BAD/ARHGAP5/KDR/MAP2K1/BIRC2/PDGFB/PTEN/MAPK9/COL1A1/ITGA3/MYLK/VAV2/PDPK1/AKT2	2.25392715211612
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	5/868	18/9376	3.0005120327701	HEXA/FUCA2/NEU1/HEXB/GLB1	2.71342398909565
Human Diseases	Cancer: specific types	hsa05214	Glioma	13/868	76/9376	1.84768372544264	BAX/GRB2/MAP2K2/CDK6/RB1/MTOR/MAP2K1/TP53/PDGFB/PTEN/CALM3/CAMK1D/AKT2	2.36990494588906
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	27/868	196/9376	1.48800902849619	GNB2/GNGT1/BAX/TNFRSF1A/MAP2K2/CDK6/RB1/GNG10/MTOR/FOS/ITPR2/MAP2K1/STAT2/TP53/ICAM1/PDGFB/MAPK9/ITPR1/CALM3/GNG7/IFNGR1/TRADD/CCR1/JAK2/MICA/AKT2/CHUK	2.20529306665366
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	15/868	93/9376	1.74223279322135	FN1/LAMA2/BAX/CDK6/RB1/CKS2/TP53/BIRC2/PTEN/BCL2L1/ITGA3/RXRB/AKT2/CDKN1B/CHUK	2.29757235789994
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	28/868	205/9376	1.47537372147915	ACTN4/ATF4/RBPJ/CHD4/PSMC1/HNRNPK/BAX/CCND2/GRB2/RHOA/GTF2A2/CDK6/RB1/GTF2A1/BAD/MRPS18B/ATF6B/ATP6V0D1/CREB3/GTF2B/CREB3L2/TP53/HDAC5/MAD1L1/GTF2H3/TRADD/CDKN1B/SRF	2.19803960976942
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	13/868	77/9376	1.82368783290442	TGFB1/BAX/CDK6/RB1/BAD/MTOR/MAP2K1/TP53/BCL2L1/MAPK9/TGFBR1/AKT2/CHUK	2.3180438638015
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	21/868	144/9376	1.5752688172043	C1QA/C1QB/C1QC/CD14/TRA2B/ACADVL/TNFRSF1A/LY96/ADIPOR2/FOXO3/LPIN1/ADH5/MAPK9/ADIPOR1/ALDH7A1/TRADD/ACOX1/AKT2/IRAK1/SREBF1/CHUK	2.22195849239389
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	12/868	70/9376	1.85174456879526	SLC2A1/TNFRSF1A/ADIPOR2/SOCS3/MTOR/MAPK9/ADIPOR1/RXRB/TRADD/JAK2/AKT2/CHUK	2.28459188079323
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	13/868	79/9376	1.77751852067899	ATP6V1G1/CLTB/ATP6V0B/ATP6V1E1/CLTC/CLTA/DNM2/ATP6V1A/ATP6V1C1/AP2S1/ATP6V0D1/ATP6V0A1/ATP6V0C	2.21658624123438
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	19/868	130/9376	1.57873094647288	COL3A1/GNB2/ATF4/GNGT1/TGFB1/GRB2/MAP2K2/MMP1/GNG10/ATF6B/FOS/MAP2K1/CREB3/CREB3L2/MAPK9/COL1A1/GNG7/TGFBR1/AKT2	2.12228252356586
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	10/868	56/9376	1.92890059249506	OSTC/B4GALT1/RPN2/RPN1/MGAT1/DDOST/STT3A/MAN1B1/MOGS/MAN1C1	2.22682996858072
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	18/868	122/9376	1.59371458789756	RHEB/PPP2R2A/PPP2R1A/RAB10/EEF2/RPTOR/ADIPOR2/MTOR/FOXO3/CREB3/CREB3L2/EEF2K/TSC2/ADIPOR1/PDPK1/TSC1/AKT2/SREBF1	2.10826232465968
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	18/868	122/9376	1.59371458789756	SLC2A1/RHEB/MED4/ACTB/MAP2K2/BAD/MTOR/MED1/MAP2K1/ATP1B1/TP53/NCOA2/TSC2/MED16/RXRB/PDPK1/SLC16A10/AKT2	2.10826232465968
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	23/868	166/9376	1.49664094164677	ADRB1/GTF2I/ATF4/GNA13/RHOA/MAP2K2/SLC25A5/PPP1CA/BAD/ATF6B/GNA11/ITPR2/MAP2K1/ATP1B1/CREB3/CREB3L2/RGS2/ITPR1/CALM3/MYLK/AKT2/SLC8A1/SRF	2.06204675257357
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	17/868	115/9376	1.5967942296133	ATF4/GNA13/RHOA/ATF6B/GNA11/KL/LRP6/FOS/ITPR2/MAP2K1/CREB3/CREB3L2/ITPR1/MMP14/ARHGEF1/RXRB/SP1	2.05672559907081
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	27/868	204/9376	1.42965573326105	FN1/GPC3/IGF2/HGF/ACTB/DCN/TGFB1/GRB2/RHOA/MAP2K2/PPP1CA/MTOR/KDR/ITPR2/WNT2/MAP2K1/TP53/PDCD4/ITPR1/COL1A1/CD44/HCLS1/ARHGEF1/VAV2/PDPK1/AKT2/FZD4	1.9816886965072
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	8/868	42/9376	2.05749396532807	IDO1/IDO2/AOC1/ALDH7A1/AFMID/DLD/KYAT3/CAT	2.1938170368045
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	19/868	133/9376	1.54312047399605	KIF5B/PPP2R2A/GNB2/ATF4/PPP2R1A/GNGT1/PPP1CA/GNG10/GSK3A/ATF6B/FOS/ITPR2/CREB3/CREB3L2/MAPK9/ITPR1/CALM3/GNG7/AKT2	2.0148711517372
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	17/868	116/9376	1.58302876211664	PGLS/SDHC/PGAM1/TKT/IDH3G/MDH1/ADPGK/ADH5/ME2/RPIA/GCSH/IDH2/DLD/ACOX1/H6PD/IDH1/CAT	2.01811189155468
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	15/868	99/9376	1.63664292696551	BAX/GRB2/MAP2K2/RB1/BAD/MTOR/MED1/FOS/MAP2K1/TP53/MAPK9/SP1/AKT2/CARM1/CDKN1B	2.03395573740798
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/868	21/9376	2.57186745666008	ENPP1/CSAD/PPCS/AASDHPPT/COASY	2.30322005895965
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	12/868	75/9376	1.72829493087558	BAX/TOP2B/BAD/MSH3/ATM/TP53/BIRC2/MSH6/BCL2L1/PDPK1/GSTA4/AKT2	2.02257603385528
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	16/868	109/9376	1.58559167970236	SPP1/CCL3/CD14/MAP2K2/LY96/CCL4L2/CCL4/FOS/MAP2K1/STAT2/MAP3K8/MAPK9/AKT2/TOLLIP/IRAK1/CHUK	1.96413043432496
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	16/868	109/9376	1.58559167970236	SLC2A1/OGA/TNFRSF1A/NR1H2/PPP1CA/SOCS3/MTOR/CREB3/CREB3L2/GFPT1/PPP1R3B/PTEN/MAPK9/PDPK1/AKT2/SREBF1	1.96413043432496
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/868	59/9376	1.83082090135125	BAX/GRB2/MAP2K2/BAD/FOXO3/MAP2K1/TP53/PTEN/PDPK1/AKT2	2.04468839463405
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	22/868	163/9376	1.45791750303921	ATF4/TGFB1/BAX/ATP6AP1/GRB2/MAP2K2/RB1/BAD/ATF6B/FOS/MAP2K1/STAT2/CREB3/CREB3L2/TP53/MAPK9/TGFBR1/JAK2/AKT2/IRAK1/IFIH1/CHUK	1.88370231162432
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	16/868	112/9376	1.54312047399605	LAMA2/TGFB1/TNFRSF1A/LY96/IL10RB/BAD/BIRC2/HLA-DRA/BCL2L1/MAPK9/IFNGR1/PDPK1/JAK2/AKT2/IRAK1/CHUK	1.84687572481946
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/868	30/9376	2.16036866359447	SDHC/IDH3G/MDH1/IDH2/DLD/IDH1	2.03317841824446
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	5/868	23/9376	2.34822680825486	IDI1/HMGCS1/ICMT/GGPS1/MVD	2.0676792499713
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/868	38/9376	1.98981324278438	HEXA/NAGK/HEXB/GFPT1/UXS1/PGM3/GALT	1.95276455561413
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	19/868	140/9376	1.46596445029625	SPP1/APLNR/APLN/GNB2/GNGT1/GNA13/MAP2K2/GNG10/MTOR/ITPR2/MAP2K1/HDAC5/ITPR1/CALM3/GNG7/MYLK/TGFBR1/AKT2/SLC8A1	1.77421644490203
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	15/868	105/9376	1.54312047399605	CD14/IL1R1/PARP1/TNFRSF1A/LY96/CCL4L2/CCL4/CFLAR/ATM/BIRC2/ICAM1/BCL2L1/TRADD/IRAK1/CHUK	1.7875545088875
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/868	31/9376	2.09067935186562	GRHPR/MDH1/GCSH/AFMID/DLD/CAT	1.94276399264574
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	19/868	142/9376	1.44531706367236	FCGR2B/FCGR3A/TYROBP/TGFB1/GRB2/IL1R1/TNFRSF1A/SOCS3/FCGR1A/FOS/ITPR2/MAP2K1/STAT2/MAPK9/ITPR1/IFNGR1/TGFBR1/AKT2/CHUK	1.70785239862569
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	18/868	133/9376	1.46190360694363	TGFB1/CCND2/GRB2/MAP2K2/FOXO3/MAP2K1/ATM/PTEN/MAPK9/CDKN2D/PLK2/TGFBR1/PDPK1/STK4/AKT2/CDKN1B/CHUK/CAT	1.71357239705318
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	8/868	47/9376	1.83861162859104	GRHPR/GLO1/MDH1/ADH5/ME2/HAGH/ALDH7A1/DLD	1.8408738259456
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	27/868	216/9376	1.35023041474654	CCL3/CD14/CYBB/ATF4/MIB1/BAX/TNFRSF1A/RHOA/LY96/MMP1/BAD/TANK/FOS/TP53/ICAM1/BCL2L1/MAPK9/ITPR1/CALM3/ARHGEF1/RXRB/VAV2/PDPK1/JAK2/AKT2/IRAK1/CHUK	1.66327767122715
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	14/868	98/9376	1.54312047399605	FCGR2B/FCGR3A/ARPC5/ACTR2/DNM2/CRK/ARF6/FCGR1A/MAP2K1/ARPC3/ARPC1B/INPP5D/VAV2/AKT2	1.72629013451267
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/868	56/9376	1.73601053324556	CD14/RAB1A/SAR1A/ARF1/RAB1B/CR1/SAR1B/SEC22B/NAIP	1.76441949317735
Human Diseases	Cancer: specific types	hsa05218	Melanoma	11/868	73/9376	1.62767502051638	HGF/BAX/MAP2K2/CDK6/RB1/BAD/MAP2K1/TP53/PDGFB/PTEN/AKT2	1.71955679719292
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/868	33/9376	1.96397151235861	STX18/SEC22B/BET1/VAMP4/VAMP7/YKT6	1.77177983814149
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	11/868	75/9376	1.58427035330261	IGFBP3/BAX/CCND2/CDK6/SHISA5/ATM/TP53/PTEN/BCL2L1/TSC2/ZMAT3	1.62259980645658
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/868	50/9376	1.72829493087558	AOC1/SMS/SRM/CNDP2/AMD1/P4HA2/PYCR2/ALDH7A1	1.64921145995374
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/868	19/9376	2.27407227746786	HEXA/HYAL2/HEXB/GLB1	1.77555574514909
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/868	68/9376	1.58850637029005	CD14/GRB2/MAP2K2/FCGR1A/BAD/MTOR/MAP2K1/PER2/AKT2/CHUK	1.55564034337348
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	11/868	78/9376	1.52333687817559	C1QA/C1QB/C1QC/CD14/RHOA/LY96/FOS/C4BPB/MAPK9/CALM3/IRAK1	1.48240076354445
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	12/868	87/9376	1.4899094231686	MT-CO3/MT-CYB/MT-CO2/MT-CO1/COX7B/COX8A/UQCRFS1/ATP1B1/UQCR10/SLC8A1/TPM1/UQCRB	1.46629953896789
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/868	53/9376	1.63046691592035	CLTB/CLTC/CLTA/DNM2/AP2S1/KL/ATP1B1/SLC8A1	1.47012463292024
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/868	71/9376	1.52138638281301	SLC2A1/PGAM1/MAP2K2/MTOR/MAP2K1/TP53/PTEN/IDH2/AKT2/IDH1	1.40851809346727
NA	NA	hsa04518	Integrin signaling	19/868	154/9376	1.33269495481477	SPP1/FN1/LAMA2/ACTN4/FLT1/HGF/ACTB/TGFB1/CCND2/COL6A2/MTOR/KDR/ICAM2/ITGAE/ICAM1/PDGFB/COL1A1/ITGA3/AKT2	1.3296146042114
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/868	37/9376	1.7516502677793	NANS/NAGK/GFPT1/UXS1/PGM3/GALT	1.46318166711008
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/868	37/9376	1.7516502677793	HBA2/HBA1/HBB/IDO1/IDO2/ICAM1	1.46318166711008
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8/868	54/9376	1.60027308414405	SMS/SRM/MDH1/MAT2B/GCLM/AMD1/DNMT1/KYAT3	1.41293753071797
Human Diseases	Infectious disease: viral	hsa05162	Measles	17/868	136/9376	1.35023041474654	FCGR2B/BAX/CCND2/CDK6/BAD/CD46/FOS/STAT2/TP53/BCL2L1/MAPK9/TRADD/AKT2/IRAK1/CDKN1B/IFIH1/CHUK	1.31407177503569
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	34/868	300/9376	1.2242089093702	CD14/ATF4/FLT1/IGF2/HGF/TAOK3/TGFB1/MAP3K11/CRK/GRB2/IL1R1/TNFRSF1A/MAP2K2/MAP3K13/KDR/PPM1A/FOS/RPS6KA5/MAP2K1/TP53/PDGFB/MAP3K8/MAP4K3/MAPK9/DUSP3/TRADD/AREG/TGFBR1/TAOK2/STK4/AKT2/IRAK1/CHUK/SRF	1.26066010713146
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	9/868	63/9376	1.54312047399605	RAD23A/POLR2F/POLR2K/POLR2E/GTF2H5/POLE3/RPA3/GTF2H3/ERCC5	1.38150801256012
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	19/868	155/9376	1.32409692284822	ATF4/MAP2K2/CDK6/AIP/RB1/ATF6B/GNA11/ITPR2/WNT2/MAP2K1/CREB3/CREB3L2/ITPR1/SCARB1/DVL3/SP1/FZD4/CDKN1B/ASH2L	1.29952161001833
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	19/868	156/9376	1.31560912206074	EIF3E/PPP2R2A/PPP2R1A/BAX/GRB2/TNFRSF1A/MAP2K2/CDK6/RB1/SOCS3/BAD/MAP2K1/CFLAR/STAT2/TP53/SCARB1/TRADD/AKT2/CHUK	1.26963283627816
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	8/868	55/9376	1.57117720988689	HEXA/DEGS1/NEU1/HEXB/SMPD4/SGPP1/PSAP/GLB1	1.3569152443078
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	25/868	214/9376	1.26189758387527	GNB2/RNF7/GNGT1/BAX/CRK/TNFRSF1A/MAP2K2/GNG10/BAD/MTOR/GNA11/FOS/ITPR2/MAP2K1/ATM/BCL2L1/MAPK9/ITPR1/AP1M1/CALM3/GNG7/TRADD/AKT2/IRAK1/CHUK	1.23786987785147
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	19/868	157/9376	1.30722944612404	BMP5/PPP2R2A/PPP2R1A/ACTB/TGFB1/CCND2/MOB1A/PPP1CA/LATS1/WNT2/SAV1/BIRC2/BMP6/AREG/TGFBR1/DVL3/DLG5/FZD4/SNAI2	1.23994527159245
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	14/868	110/9376	1.37478005865103	BMP5/PPP2R1A/SMAD5/DCN/TGFB1/RHOA/BMP6/LRRC32/TFDP1/TFRC/TGFBR1/SP1/SMAD6/PITX2	1.26286936934733
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	11/868	83/9376	1.43156959635778	RBBP7/ASXL2/LCOR/SCML1/PCGF5/PCGF2/BMI1/SFMBT1/FBRS/TFDP1/RNF2	1.26137343185914
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/868	65/9376	1.49563984402694	ATF4/ATF6B/GNA11/ITPR2/CREB3/CREB3L2/ITPR1/SCARB1/SP1	1.28072676847088
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/868	65/9376	1.49563984402694	SPP1/MAP2K2/CGA/GNA11/ITPR2/MAP2K1/ITPR1/TRPC1/AKT2	1.28072676847088
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	18/868	149/9376	1.30492066928525	FCER1G/RHEB/ARF1/DNM2/GNA13/GRB2/RHOA/ARF6/MAP2K2/MTOR/MAP2K1/PDGFB/TSC2/CYTH1/TSC1/AKT2/DGKZ/AGPAT1	1.19834397980187
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/868	75/9376	1.44024577572965	ATF4/CANX/CGA/ATF6B/ITPR2/ATP1B1/CREB3/CREB3L2/PDIA4/ITPR1	1.22262357905788
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	13/868	103/9376	1.36333944789942	SRRM1/PPP2R2A/PPP2R1A/FIP1L1/MAGOH/PPP1CA/PABPC4/WDR82/CPSF7/CPSF2/DDX19A/NXF1/NUDT21	1.18427563573096
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/868	15/9376	2.16036866359447	HEXA/HEXB/GLB1	1.43652192559213
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/868	23/9376	1.87858144660389	SSBP1/MSH3/MSH6/RPA3	1.34741767144065
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	7/868	49/9376	1.54312047399605	B4GALT1/GALNT15/GALNT7/MFNG/POGLUT1/C1GALT1/COLGALT1	1.21746079962161
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/868	32/9376	1.68778801843318	BAX/TNFRSF1A/BIRC2/BCL2L1/MAPK9	1.24478670280067
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/868	41/9376	1.58075755872766	MAP2K2/MMP1/RB1/RPS6KA5/MAP2K1/TP53	1.19031360735453
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	14/868	115/9376	1.31500701262272	GNB2/ATF4/GNGT1/GNG10/GNA11/FOS/ITPR2/MAP2K1/CREB3/CREB3L2/ITPR1/GNG7/JAK2/AKT2	1.08560531352284
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/868	59/9376	1.464656721081	HPGDS/SMS/SRM/GPX4/GCLM/IDH2/GSTA4/IDH1	1.14354153047645
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/868	50/9376	1.51225806451613	HBA2/HBA1/HBB/HGF/TGFB1/CR1/ICAM1	1.15999965760857
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	22/868	193/9376	1.23129820204866	CXCL14/CCL3/GNB2/GNGT1/CRK/GRB2/RHOA/CCL4L2/GNG10/CCL4/BAD/GSK3A/FOXO3/MAP2K1/STAT2/GNG7/VAV2/CCR1/JAK2/AKT2/GRK2/CHUK	1.03702775356997
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	10/868	78/9376	1.38485170743235	FCGR3A/CYBB/TGFB1/CR1/FCGR1A/FOS/HLA-DRA/IFNGR1/JAK2/IRAK1	1.09012853620779
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/868	69/9376	1.40893608495292	FCER1G/GRB2/MAP2K2/MAP2K1/MAPK9/INPP5D/VAV2/PDPK1/AKT2	1.08894735267968
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	14/868	117/9376	1.2925282602702	CHD4/ACTB/RBBP7/SMARCB1/ARID1A/POLE3/CHD3/BCL7B/ACTL6A/UCHL5/MBD3/DPF2/INO80E/SMARCD2	1.01697546926828
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/868	52/9376	1.45409429280397	PLTP/TSPO/APOE/APOC1/STARD3NL/LIPA/SCARB1	1.04876538097307
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	13/868	109/9376	1.28829323975817	TGFB1/IL1R1/MTOR/FOS/HLA-DRA/IL4R/MAPK9/EBI3/IFNGR1/RXRB/TGFBR1/JAK2/CHUK	0.966963066324589
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/868	139/9376	1.24337764811193	ATF4/KRT10/GRB2/MAP2K2/CTSD/ATF6B/FOS/ITPR2/MAP2K1/CREB3/CREB3L2/NCOA2/ITPR1/CALM3/SP1/AKT2	0.923324540256687
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/868	44/9376	1.47297863426896	RAB5B/CREB3/CREB3L2/DCTN6/DCTN5/DCTN4	1.00441284082125
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	12/868	101/9376	1.28338732490761	FN1/COL3A1/CYBB/TGFB1/BAX/ICAM1/MAPK9/COL1A1/TGFBR1/JAK2/AKT2/CDKN1B	0.914567805922264
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	17/868	150/9376	1.2242089093702	HGF/TGFB1/BAX/GRB2/MAP2K2/RB1/MTOR/LRP6/WNT2/MAP2K1/TP53/RXRB/TGFBR1/DVL3/AKT2/FZD4/CDKN1B	0.884145072132525
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/868	18/9376	1.80030721966206	CD320/MMADHC/ZNF76	1.08550849627758
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	25/868	232/9376	1.16399173685047	FN1/TMSB4X/C7/ARPC5/ACTN4/CYFIP1/ACTB/ACTR2/CRK/GNA13/RHOA/MAP2K2/PPP1CA/ITGAE/MAP2K1/PDGFB/ARPC3/ARPC1B/ARHGEF1/ITGA3/MYLK/VAV2/ENAH/AKT2/SPATA13	0.807847916928437
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	16/868	142/9376	1.21710910625041	ACTB/IL1R1/TNFRSF1A/RHOA/KDR/FOS/ARHGEF2/TP53/ICAM1/PDGFB/CDH5/MAPK9/CALM3/GSTA4/AKT2/CHUK	0.832643386299799
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	11/868	93/9376	1.27763738169565	ATF4/GRB2/MAP2K2/CGA/GNA11/ITPR2/MAP2K1/MAPK9/ITPR1/CALM3/MMP14	0.859423053696064
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	19/868	173/9376	1.1863296129565	ACTB/BAX/KPNA6/TNFRSF1A/MAP2K2/SLC25A5/CDK6/SOCS3/MAP2K1/STAT2/ICAM1/HLA-DRA/IFNGR1/NXF1/TRADD/JAK2/AKT2/IFIH1/CHUK	0.790081663361555
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/868	37/9376	1.45970855648275	BAX/MAP2K2/MAP2K1/TP53/RXRB	0.894880452908587
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	22/868	205/9376	1.15922220973362	RBPJ/PSMC1/BAX/ADRM1/PSMD12/CCND2/PSMC6/CD58/CDK6/RB1/PSMD3/STAT2/TP53/ICAM1/HLA-DRA/MAPK9/CD44/TRADD/AKT2/IRAK1/CDKN1B/CHUK	0.73621386276998
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	10/868	86/9376	1.25602829278748	CRK/GRB2/MAP2K2/BAD/MTOR/MAP2K1/MAPK9/AREG/AKT2/CDKN1B	0.761835294890966
NA	NA	hsa04517	IgSF CAM signaling	31/868	299/9376	1.11992355470616	JAM2/SLIT2/ARPC5/ACTN4/ACTB/ACTR2/TUBA1C/GRB2/NRP1/RHOA/ARF6/MAP2K2/KDR/ICAM2/MAP2K1/TUBB2A/ICAM1/PTPRD/ARPC3/MAPK9/ARPC1B/CADM3/CSK/INPP5D/MYLK/CASKIN2/VAV2/PDPK1/AKT2/PLXNA4/LMO7	0.673132686309306
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	25/868	238/9376	1.13464740735004	GNB2/FLT1/IGF2/HGF/GNGT1/PLAAT3/GRB2/RHOA/ARF6/MAP2K2/GNG10/BAD/RAB5B/KDR/MAP2K1/PDGFB/BCL2L1/MAPK9/CALM3/GNG7/RGL1/PLA2G2A/STK4/AKT2/CHUK	0.672036184262036
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	17/868	157/9376	1.16962634653204	C1QA/SLC2A1/C1QB/C1QC/UQCRFS1/TGFB1/CRK/MAP2K2/MERTK/ADAM9/NR1H2/LIPA/RAB5B/MAP2K1/STAB1/JAK2/AXL	0.684593840119686
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/868	39/9376	1.38485170743235	MAT2B/ALDH7A1/GCSH/DLD/MTHFD2L	0.769225728851818
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	16/868	148/9376	1.1677668451862	BAX/GRB2/MAP2K2/CDK6/RB1/MTOR/LRP6/FOS/WNT2/MAP2K1/TP53/PTEN/DVL3/SP1/AKT2/FZD4	0.657075028787726
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/868	88/9376	1.22748219522413	F13A1/C1QA/SERPINE2/C1QB/C1QC/C7/CR1/CD46/C4BPB/VSIG4	0.684793143740961
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	11/868	98/9376	1.2124518009969	IPMK/ITPR2/PTEN/INPP5B/ITPR1/MTMR14/CALM3/SACM1L/INPP5D/IMPA2/DGKZ	0.675270894175607
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	11/868	98/9376	1.2124518009969	ATF4/ATF6B/GNA11/ITPR2/ATP1B1/CREB3/CREB3L2/ITPR1/SCARB1/CALM3/CAMK1D	0.675270894175607
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/868	12/9376	1.80030721966206	FCGR2B/CD46	0.886029976633583
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/868	89/9376	1.21369026044633	ADRB1/TUBA1C/GRB2/MAP2K2/GNA11/ITPR2/MAP2K1/TUBB2A/PDGFB/ITPR1	0.646954546306774
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/868	60/9376	1.26021505376344	PPP2R1A/GNA13/MAP2K2/GNA11/ITPR2/MAP2K1/ITPR1	0.645840183485181
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	12/868	110/9376	1.17838290741517	SLC2A1/CYBB/EGLN2/FLT1/MAP2K2/EPAS1/MTOR/MAP2K1/IFNGR1/TFRC/AKT2/CDKN1B	0.601084034728473
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/868	31/9376	1.39378623457708	PGLS/TKT/RPIA/H6PD	0.701428624304017
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/868	31/9376	1.39378623457708	CSAD/CNDP2/ALDH7A1/ACOX1	0.701428624304017
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/868	41/9376	1.31729796560638	PGAM1/GRHPR/ALDH7A1/GCSH/DLD	0.650330039396524
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/868	41/9376	1.31729796560638	SSBP1/BABAM1/RAD51B/ATM/RPA3	0.650330039396524
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/868	22/9376	1.47297863426896	AOC1/CNDP2/ALDH7A1	0.709391435166922
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	13/868	122/9376	1.15101609125935	PPP2R2A/PPP2R1A/GRB2/RHOA/MAP2K2/FOS/MAP2K1/MAP3K8/MAPK9/VAV2/PDPK1/AKT2/CHUK	0.536253516604492
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/868	32/9376	1.35023041474654	B4GALT1/GAA/GALT/GLB1	0.63386123559699
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/868	62/9376	1.21956295525494	RBPJ/TLE4/APH1A/MFNG/CTBP1/NCSTN/DVL3	0.554011214226611
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	11/868	103/9376	1.15359491745336	COL3A1/COL15A1/COL11A1/PRCP/COL6A2/SLC3A2/ATP1B1/COL1A1/SLC16A10/SLC7A7/SLC8A1	0.500630249656985
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	11/868	103/9376	1.15359491745336	FN1/COL3A1/LAMA2/CD14/ACTN4/TGFB1/IL1R1/SERPINB6/RAB5B/GNA11/COL1A1	0.500630249656985
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/868	23/9376	1.40893608495292	B4GALT1/FKTN/POMGNT1	0.627156092910005
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	24/868	238/9376	1.08926151105604	F13A1/C1QA/C1QB/C1QC/C7/RPL27A/CYBB/RPL23/RPLP1/NRP1/TNFRSF1A/RPL4/MMP1/RPL36AL/RPS24/FOS/STAT2/RPL26L1/MAPK9/RPL38/RPS10/IRAK1/IFIH1/CHUK	0.445511476768477
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	9/868	83/9376	1.17128421520182	SCP2/AGPS/PEX2/ABCD3/IDH2/ACOX1/PEX26/IDH1/CAT	0.500622287055891
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	9/868	83/9376	1.17128421520182	PCBP1/POLR2F/POLR2K/POLR2E/CCL4L2/CCL4/IFI16/DDX41/CHUK	0.500622287055891
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/868	73/9376	1.18376365128464	SERINC3/RANBP2/PIN1/VPS4B/VPS4A/SMARCB1/NELFE/CPSF7	0.503432549193261
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/868	33/9376	1.30931434157241	IDH3G/IDH2/DLD/IDH1	0.56851982348014
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	19/868	187/9376	1.0975134922004	PKN1/CYBB/PKN2/CARD8/RHOA/TANK/CARD16/IFI16/ITPR2/STAT2/BIRC2/NAIP/GPSM3/BCL2L1/MAPK9/ITPR1/CHUK/TRPV2/CARD18	0.430212621567045
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/868	14/9376	1.54312047399605	B4GALT1/B3GNT2	0.649542592409275
Organismal Systems	Immune system	hsa04611	Platelet activation	13/868	126/9376	1.11447589788604	COL3A1/P2RY1/FCER1G/ACTB/GNA13/RHOA/PPP1CA/ITPR2/ITPR1/COL1A1/ARHGEF1/MYLK/AKT2	0.413199916364542
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	17/868	168/9376	1.09304366908054	FTL/CYBB/CHMP5/VPS4B/BAX/VPS4A/PARP1/TNFRSF1A/SLC25A5/CHMP1A/CFLAR/STAT2/BIRC2/MAPK9/IFNGR1/TRADD/JAK2	0.388678549864507
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	9/868	85/9376	1.14372458660884	APRT/ENPP1/DUT/HPRT1/DTYMK/NT5C/AK6/IMPDH2/CANT1	0.425148901380872
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	16/868	158/9376	1.09385755118707	CDKN1C/PPP2R1A/TGFB1/CCND2/RAD21/CDK6/RB1/ATM/TP53/TFDP1/ANAPC13/MAU2/MAD1L1/CDKN2D/CDKN1B/ANAPC15	0.38002412761547
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	8/868	75/9376	1.15219662058372	PGAM1/TKT/IDH3G/RPIA/MAT2B/PYCR2/IDH2/IDH1	0.422671124260486
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/868	67/9376	1.12855079441502	ATF4/MAP2K2/PPP1CA/ITPR2/MAP2K1/ITPR1/CALM3	0.337281415000493
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/868	36/9376	1.20020481310804	SSBP1/POLE3/RPA3/POLA1	0.384400626265265
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/868	26/9376	1.24636653668912	PLAAT3/PLA2G2A/ACOX1	0.4017855811124
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	14/868	142/9376	1.0649704679691	RNF7/UBE2M/UBE2A/UBE2S/WWP2/SOCS3/UBE2F/WWP1/BIRC2/UBA3/CDC34/ANAPC13/PRPF19/ANAPC15	0.249170711415874
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/868	16/9376	1.35023041474654	HEXA/HEXB	0.447824330770968
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/868	90/9376	1.08018433179724	MAP2K2/MTOR/FOS/MAP2K1/PTEN/IFNGR1/JAK2/AKT2/CHUK	0.244133956605194
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	15/868	154/9376	1.0521275959064	IDO1/IDO2/UROD/DHRS3/MOCS2/PPCS/MAT2B/GCLM/AFMID/DLD/COASY/NADK2/AK6/GGCX/MTHFD2L	0.208327814403333
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	15/868	154/9376	1.0521275959064	ADRB1/PPP2R2A/ATF4/PPP2R1A/CREM/PPP1CA/ATF6B/RPS6KA5/ATP1B1/CREB3/CREB3L2/CALM3/AKT2/SLC8A1/TPM1	0.208327814403333
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/868	69/9376	1.0958391771856	ATF4/PPP1CA/ATF6B/FOS/CREB3/CREB3L2/CALM3	0.255208141612828
NA	NA	hsa03272	Virion - Hepatitis viruses	5/868	48/9376	1.12519201228879	IST1/VPS4B/VPS4A/CHMP1A/SCARB1	0.277737633247945
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/868	27/9376	1.20020481310804	HACD3/SCP2/ACOX1	0.332740432264529
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/868	59/9376	1.09849254081075	ENPP1/DUT/NUDT2/DTYMK/NT5C/CANT1	0.242394666318844
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	9/868	91/9376	1.06831417430496	FCGR2B/GRB2/MAP2K2/FOS/MAP2K1/INPP5D/VAV2/AKT2/CHUK	0.209156962342664
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/868	17/9376	1.27080509623204	SEPHS2/KYAT3	0.356942556822149
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	16/868	168/9376	1.02874698266403	PRLR/CSH1/PTPN2/CCND2/GRB2/OSMR/IL10RB/SOCS3/MTOR/STAT2/PDGFB/IL4R/BCL2L1/IFNGR1/JAK2/AKT2	0.120087004793043
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	9/868	93/9376	1.04533967593281	RBPJ/MAF/FOS/HLA-DRA/IL4R/MAPK9/IFNGR1/JAK2/CHUK	0.140348401594128
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	19/868	201/9376	1.0210697663755	IGFBP3/CD14/FLT1/KLF3/BAX/CCND2/FCGR1A/MAF/ATM/TP53/BIRC2/PER2/BMI1/BCL2L1/RXRB/PRCC/SP1/CDKN1B/HPGD	0.0964465001383812
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/868	72/9376	1.05017921146953	PIN1/TANK/MAPK9/TRADD/RNF125/IFIH1/CHUK	0.136517079832352
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/868	29/9376	1.11743206737645	MOB1A/LATS1/SAV1	0.202293227963272
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/868	51/9376	1.05900424686003	PLAAT3/ENPP2/AGPS/PLD3/PLA2G2A	0.134950873294685
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	6/868	63/9376	1.02874698266403	PLOD2/PRDM6/KMT5A/ALDH7A1/DLD/COLGALT1	0.0731222422809598
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/868	63/9376	1.02874698266403	HPGDS/PLAAT3/PTGDS/GPX4/PLA2G2A/HPGD	0.0731222422809598
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/868	30/9376	1.08018433179724	PIGT/PIGN/PIGS	0.140497634938259
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/868	30/9376	1.08018433179724	FOLR2/ABCC5/CHUK	0.140497634938259
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/868	19/9376	1.13703613873393	GCSH/DLD	0.190974490007469
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	10/868	107/9376	1.00951806710022	SLC2A1/ATF4/PGAM1/PPP4C/ITPR2/CREB3/CREB3L2/ITPR1/CALM3/AKT2	0.0316268522777504
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/868	97/9376	1.00223288517269	GNB2/GNGT1/GNG10/FOS/RPS6KA5/PER2/ITPR1/CALM3/GNG7	0.00706046703661967
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/868	76/9376	0.99490662139219	PLTP/SCP2/MMP1/HMGCS1/RXRB/PDPK1/ACOX1	-0.0142397722070588
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/868	20/9376	1.08018433179724	LIPA/FDFT1	0.114654516137841
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	14/868	154/9376	0.981985756179305	ACTB/EEF2/RHOA/MAP2K2/PPP1CA/FOS/ITPR2/MAP2K1/EEF2K/RGS2/ITPR1/CALM3/MYLK/CAMK1D	-0.0719938830486836
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/868	43/9376	1.00482263422999	ACADVL/ADH5/ALDH7A1/ACOX1	0.0101237096122981
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	9/868	99/9376	0.981985756179305	C1QA/FCGR2B/C1QB/C1QC/FCGR3A/KRT10/FCGR1A/ICAM1/HLA-DRA	-0.0575521583956196
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/868	32/9376	1.01267281105991	ECHDC1/DLD/ACOX1	0.0229357683933121
Human Diseases	Immune disease	hsa05310	Asthma	3/868	32/9376	1.01267281105991	PRG2/FCER1G/HLA-DRA	0.0229357683933121
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	13/868	144/9376	0.975166410650282	SMAD5/GRB2/MAP2K2/PCGF5/WNT2/MAP2K1/PCGF2/BMI1/DVL3/JAK2/AKT2/FZD4/KLF4	-0.0959189914384546
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	12/868	133/9376	0.974602404629084	FCGR3A/TYROBP/FCER1G/GRB2/MAP2K2/HCST/ICAM2/MAP2K1/ICAM1/IFNGR1/VAV2/MICA	-0.094220131050933
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	21/868	233/9376	0.973556693894504	FN1/TNNT3/COL3A1/LAMA2/CAPZB/CAPZA1/CAPZA2/COL11A1/ACTB/DCN/COL6A2/TMEM43/ATP1B1/CSRP2/NID2/COL1A1/ITGA3/NEBL/SYNPO2/SGCB/TPM1	-0.130551273668049
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/868	100/9376	0.972165898617511	CD14/CR1/IL1R1/FCGR1A/HLA-DRA/IL4R/CD44/ITGA3/TFRC	-0.0893775807198258
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	4/868	44/9376	0.981985756179305	PARP1/POLE3/POLG2/NTHL1	-0.0382548734768057
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/868	21/9376	1.02874698266403	CHSY1/DSE	0.0421222710768831
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/868	78/9376	0.969396195202647	IPMK/PTEN/INPP5B/MTMR14/SACM1L/INPP5D/IMPA2	-0.0866881458022158
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	12/868	134/9376	0.967329252355733	GNA13/RHOA/MAP2K2/PPP1CA/GNA11/ITPR2/MAP2K1/ITPR1/CALM3/ARHGEF1/MYLK/PLA2G2A	-0.121663484397475
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/868	45/9376	0.960163850486431	ABCD3/ABCB7/ABCC5/ABCB8	-0.0855561584365253
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	5/868	57/9376	0.94753011561161	ACADVL/HACD3/SCP2/PPT1/ACOX1	-0.126909647965221
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/868	34/9376	0.953103822174031	POLR2F/POLR2K/POLR2E	-0.0874961079890985
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/868	104/9376	0.934774902516838	PLAAT3/LPIN1/MBOAT7/PLD3/LYPLA2/PLA2G2A/PGS1/DGKZ/AGPAT1	-0.213636992347658
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	19/868	217/9376	0.94578351632016	ADRB1/ATF4/KPNA6/GRB2/MAP2K2/AIP/RB1/BAD/ATF6B/MTOR/FOS/MAP2K1/CREB3/CREB3L2/RXRB/GSTA4/JAK2/AKT2/KLF4	-0.258088673033545
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/868	70/9376	0.92587228439763	LAMA2/ACTB/EIF4G2/ICAM1/HLA-DRA/SGCB	-0.198829066144162
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/868	23/9376	0.939290723301943	ATP6AP2/PRCP	-0.0931054856206425
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/868	23/9376	0.939290723301943	MDH1/ATP1B1	-0.0931054856206425
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	9/868	105/9376	0.92587228439763	FCER1G/RHOA/ITPR2/STAT2/MAPK9/ITPR1/CALM3/AKT2/CHUK	-0.243974106303918
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/868	36/9376	0.900153609831029	GALNT15/GALNT7/C1GALT1	-0.19170875222948
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/868	60/9376	0.900153609831029	MAP2K2/BAD/KDR/MAP2K1/AKT2	-0.24781352967259
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/868	49/9376	0.881783127997743	ATF4/ATF6B/CREB3/CREB3L2	-0.264995363657898
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/868	12/9376	0.900153609831029	GGCX	-0.11054116791014
NA	NA	hsa04519	Cadherin signaling	35/868	404/9376	0.935803257745129	ARPC5/ACTN4/MYO1C/CYFIP1/TAOK3/ACTB/KRT10/ACTR2/RHOA/MAP2K2/ATN1/MOB1A/APH1A/PPP1CA/PCDH12/LATS1/KDR/LRP6/WNT2/MAP2K1/SAV1/KRT7/CDH5/ARPC3/MAPK9/ARPC1B/CDH11/NCSTN/VAV2/TAOK2/DVL3/ENAH/FZD4/CHUK/TMC6	-0.421299360669216
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/868	62/9376	0.871116396610673	RPTOR/MTOR/FOXO3/AKT2/CAT	-0.325204957843244
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/868	86/9376	0.879219804951238	SLC2A1/ATF4/ATF6B/GNA11/ATP1B1/CREB3/CREB3L2	-0.359392372265433
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/868	38/9376	0.852777104050449	ENPP1/NT5C/NADK2	-0.290450400700264
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/868	63/9376	0.857289152220028	BAX/WNT2/TP53/DVL3/FZD4	-0.363006347812094
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	14/868	170/9376	0.889563567362429	JAM2/ARPC5/PPP2R2A/ACTN4/PPP2R1A/ACTB/ACTR2/TUBA1C/RHOA/ARHGEF2/ARPC3/MAPK9/ARPC1B/HCLS1	-0.464123015223286
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/868	76/9376	0.852777104050449	ACTB/ITPR2/ATP1B1/ITPR1/CALM3/MYLK	-0.411597225223079
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/868	52/9376	0.830911024459412	HSD17B2/CGA/BMP6/SCARB1	-0.390523877224164
Cellular Processes	Cell motility	hsa04814	Motor proteins	16/868	194/9376	0.89087367570906	TNNT3/KIF5B/CAPZB/CAPZA1/CAPZA2/MYO1C/ACTB/ACTR10/TUBA1C/TUBB2A/DCTN6/DCTN5/DCTN4/TUBE1/TPM1/KIF21A	-0.490561552948844
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	7/868	89/9376	0.849583182312432	SPP1/FN1/LAMA2/COL6A2/COL1A1/CD44/ITGA3	-0.455392041924201
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	8/868	101/9376	0.855591549938404	MAP2K2/WNT2/MAP2K1/CREB3/CREB3L2/CALM3/DVL3/FZD4	-0.466045259337299
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/868	65/9376	0.830911024459412	ABHD16A/LPIN1/ALDH7A1/DGKZ/AGPAT1	-0.436923665112724
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/868	66/9376	0.818321463482754	TGFB1/MAF/HLA-DRA/IL4R/IFNGR1	-0.47307773658815
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/868	28/9376	0.771560236998025	HACD3/PPT1	-0.386654549785969
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/868	28/9376	0.771560236998025	B4GALT1/B3GNT2	-0.386654549785969
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/868	28/9376	0.771560236998025	MOCS2/QDPR	-0.386654549785969
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/868	67/9376	0.806107710296444	PGAM1/ADPGK/ADH5/ALDH7A1/DLD	-0.508719266391862
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	9/868	116/9376	0.838074050532338	JAM2/ACTN4/CYBB/ACTB/RHOA/ARHGAP5/ICAM1/CDH5/VAV2	-0.560494962522273
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	10/868	128/9376	0.84389400921659	APRT/ENPP1/NUDT5/NUDT2/HPRT1/PDE9A/NT5C/AK6/IMPDH2/CANT1	-0.567979164445847
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/868	29/9376	0.7449547115843	GNGT1/CALM3	-0.439351327308595
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/868	105/9376	0.822997586131227	ADRB1/LAMA2/ACTB/TGFB1/ITGA3/SLC8A1/SGCB/TPM1	-0.582562208835821
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	7/868	93/9376	0.813041970169962	ACTN4/ACTB/RHOA/CDH5/TGFBR1/SNAI2/LMO7	-0.578726250507808
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/868	43/9376	0.75361697567249	SCARB1/PLA2G2A/AGPAT1	-0.517209075526076
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	14/868	178/9376	0.849583182312432	TLE4/RSPO3/CCND2/RHOA/NOTUM/LRP6/WNT2/TP53/CTBP1/MAPK9/RSPO2/DVL3/FZD4/DKK1	-0.647129882873583
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/868	94/9376	0.804392587508579	S100A9/MMP1/SRSF1/FOS/MAPK9/TRADD/CHUK	-0.608779771331778
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/868	30/9376	0.720122887864823	PLAAT3/PLA2G2A	-0.490395959497142
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/868	31/9376	0.696893117288539	KL/ALDH7A1	-0.539906744037709
NA	NA	hsa04981	Folate transport and metabolism	2/868	31/9376	0.696893117288539	FOLR2/ABCC5	-0.539906744037709
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/868	59/9376	0.732328360540498	ADRB1/PLAAT3/CGA/AKT2	-0.65875219783876
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/868	17/9376	0.635402548116021	SCP2	-0.480568307233023
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/868	17/9376	0.635402548116021	CSAD	-0.480568307233023
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/868	17/9376	0.635402548116021	TFRC	-0.480568307233023
NA	NA	hsa04081	Hormone signaling	17/868	219/9376	0.838499252993287	ADRB1/PRLR/CSH1/GNB2/IGF2/SMAD5/GNGT1/GNA13/RHOA/CGA/ADIPOR2/GNG10/GNA11/ADIPOR1/GNG7/SLC16A10/JAK2	-0.772416862039094
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/868	46/9376	0.704468042476458	FTL/UROD/BLVRA	-0.641762452925625
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/868	99/9376	0.76376669925057	IL1R1/PPP1CA/ITPR2/MAPK9/ITPR1/CALM3/TRPV2	-0.754721456996819
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/868	99/9376	0.76376669925057	LAMA2/ACTB/TGFB1/ITGA3/SLC8A1/SGCB/TPM1	-0.754721456996819
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/868	47/9376	0.689479360721639	SOCS3/MTOR/MAPK9	-0.681637718551352
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/868	61/9376	0.708317594621138	FTL/ATOX1/ATP1B1/SLC8A1	-0.729987596345706
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/868	100/9376	0.756129032258065	CXCL14/CCL3/TNFRSF1A/CCL4L2/IL10RB/CCL4/CCR1	-0.783089664187612
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	10/868	138/9376	0.782742269418286	PPP2R1A/CPEB4/PPP1CA/ITPR2/MAP2K1/ITPR1/ANAPC13/CALM3/MAD1L1/ANAPC15	-0.821216304139967
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/868	48/9376	0.675115207373272	HMGCS1/ALDH7A1/DLD	-0.720754716956325
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	16/868	212/9376	0.815233457960177	P2RY1/RAPGEF1/FLT1/HGF/ACTB/CRK/RHOA/MAP2K2/KDR/MAP2K1/MAGI3/PDGFB/CALM3/VAV2/ENAH/AKT2	-0.869121475677129
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/868	115/9376	0.751432578641555	GNB2/GNGT1/GNG10/ITPR2/MAP2K1/ITPR1/GNG7/TRPC1	-0.856635257573105
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/868	116/9376	0.7449547115843	GNB2/GNGT1/GNG10/ITPR2/ITPR1/GNG7/TRPC1/GRK2	-0.882820819281893
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	25/868	323/9376	0.836055984363185	HNRNPK/ZEB2/CRK/CCND2/GRB2/RHOA/MAP2K2/RPTOR/CDK6/MTOR/RPS6KA5/MAP2K1/ATM/TP53/BMI1/PDGFB/PTEN/PDCD4/IGF2BP1/HDAC5/CD44/DNMT1/DICER1/CDKN1B/TPM1	-0.957706267603983
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/868	20/9376	0.540092165898618	NANS	-0.657616132790605
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/868	36/9376	0.600102406554019	KL/CRYL1	-0.767818130724224
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/868	36/9376	0.600102406554019	ENPP1/GAA	-0.767818130724224
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/868	93/9376	0.696893117288539	ADRB1/LYZ/ITPR2/ATP1B1/ITPR1/CALM3	-0.938263576558776
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/868	38/9376	0.568518069366966	ATP1B1/PDPK1	-0.851254139778863
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	11/868	160/9376	0.742626728110599	JAM2/CD58/ICAM2/VSIR/ICAM1/HLA-DRA/CDH5/PTPRD/CADM3/CD276/SIGLEC1	-1.04877895000434
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/868	82/9376	0.658648982803192	DUT/HPRT1/TPMT/GSTA4/IMPDH2	-0.991604647661079
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/868	82/9376	0.658648982803192	LGMN/CANX/CD74/HLA-DRA/NFYB	-0.991604647661079
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/868	69/9376	0.626193815534629	ADRB1/ITPR2/ITPR1/CALM3	-0.995400674987454
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	7/868	110/9376	0.687390029325513	CPEB4/MAP2K1/MAPK9/ANAPC13/MAD1L1/AKT2/ANAPC15	-1.05337930181866
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	16/868	226/9376	0.764732270298927	ADRB1/RHOA/MAP2K2/CGA/PPP1CA/BAD/FOS/MAP2K1/ATP1B1/CREB3/CREB3L2/MAPK9/CALM3/VAV2/ACOX1/AKT2	-1.14350427968731
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/868	24/9376	0.450076804915515	HS3ST3A1	-0.861563258299045
Human Diseases	Substance dependence	hsa05034	Alcoholism	13/868	191/9376	0.735203995464087	GNB2/ATF4/GNGT1/GRB2/PPP1CA/GNG10/ATF6B/MAP2K1/CREB3/CREB3L2/HDAC5/CALM3/GNG7	-1.18091949270952
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/868	86/9376	0.628014146393741	LAMA2/ACTB/ITGA3/SLC8A1/SGCB	-1.10687748370303
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/868	102/9376	0.635402548116021	RHOA/ITPR2/ATP1B1/ITPR1/PLA2G2A/TRPC1	-1.18252935215598
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/868	26/9376	0.415455512229706	SCARB1	-0.953301328423521
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	9/868	143/9376	0.679836292739519	C1QA/C1QB/C1QC/C7/FCGR3A/ACTN4/SNRPD3/FCGR1A/HLA-DRA	-1.23225463747718
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	13/868	195/9376	0.720122887864823	FCGR3A/CYBB/ACTB/CR1/MAP2K2/SLC25A5/ATG7/FCGR1A/MTOR/MAP2K1/CLCN5/HDAC5/AKT2	-1.26145411038853
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/868	89/9376	0.606845130223166	GNB2/GNGT1/GNG10/TRAK2/GNG7	-1.19028976741152
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/868	27/9376	0.400068271036013	HMGCS1	-0.997086632062931
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	12/868	184/9376	0.704468042476458	SLIT2/NRP1/RHOA/EPHA3/EFNB1/SEMA4C/PDPK1/TRPC1/ENAH/PLXNA4/PLXNB2/SEMA6B	-1.29312382767443
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	21/868	298/9376	0.761203723749729	CXCL14/BMP5/CCL3/IL1RL1/PRLR/CSH1/TGFB1/OSMR/IL1R1/TNFRSF1A/CCL4L2/ACVRL1/IL10RB/CCL4/BMP6/IL4R/EBI3/IFNGR1/TGFBR1/CCR1/TNFRSF21	-1.33805003337259
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/868	91/9376	0.593507874613865	GNB2/GNGT1/GNG10/GNG7/GRK2	-1.24455369660827
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/868	79/9376	0.546928775593537	HPGDS/AKR7A2/ADH5/GSTA4	-1.29163668209674
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/868	48/9376	0.450076804915515	ATP1B1/AKT2	-1.22000089205846
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/868	50/9376	0.432073732718894	TGFB1/HLA-DRA	-1.28605935411731
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/868	34/9376	0.31770127405801	PER2	-1.27299250756394
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/868	54/9376	0.400068271036013	CGA/HLA-DRA	-1.41213404051
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/868	73/9376	0.44391136923174	HPGDS/ADH5/GSTA4	-1.52344119747284
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/868	56/9376	0.385780118499013	CCND2/GRK2	-1.47245383464621
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/868	37/9376	0.29194171129655	GFPT1	-1.3783244038974
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/868	37/9376	0.29194171129655	ADH5	-1.3783244038974
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/868	39/9376	0.276970341486471	HLA-DRA	-1.44516187744681
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/868	44/9376	0.245496439044826	HLA-DRA	-1.60225644492389
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/868	45/9376	0.240040962621608	HLA-DRA	-1.632165171613
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/868	68/9376	0.31770127405801	DHRS3/ADH5	-1.80356828386506
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	9/868	183/9376	0.531238195965853	NOP56/POP7/NVL/NXF1/TCOF1/RCL1/AK6/POP4/NOB1	-2.04541243527907
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/868	70/9376	0.30862409479921	HPGDS/GSTA4	-1.85444303076909
NA	NA	hsa04082	Neuroactive ligand signaling	10/868	199/9376	0.542806196883033	ADRB1/P2RY1/GNB2/GNGT1/TAC3/GNG10/GNA11/GNG7/OGFR/P2RY13	-2.08213204297941
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/868	90/9376	0.360061443932412	SLC2A1/ATP1B1/SCARB1	-1.94839475712114
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/868	54/9376	0.200034135518006	RPA3	-1.88297930238133
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	13/868	254/9376	0.55285024855764	ADRB1/FLT1/HGF/SLC25A5/GNA11/KDR/ITPR2/PDGFB/ITPR1/CALM3/MYLK/CAMK1D/SLC8A1	-2.30757900093863
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/868	86/9376	0.251205658557496	P2RY1/SCN9A	-2.22810515085943
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/868	66/9376	0.163664292696551	HSD17B2	-2.1777575437559
NA	NA	hsa04382	Cornified envelope formation	7/868	217/9376	0.348446558644269	S100A9/PPP2R2A/PPP2R1A/KRT10/S100A4/BLMH/KRT7	-3.1016132304513
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	15/868	370/9376	0.437912566944825	ADRB1/P2RY1/APLNR/APLN/TSPO/PRLR/CSH1/TAC3/NR3C1/PGRMC1/CGA/SPX/PGRMC2/OGFR/P2RY13	-3.52346958117503
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/868	449/9376	0.12028778750526	RGS2/CALM3/GNG7/SLC8A1/GRK2	-6.1015866664976