category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	101/657	238/9376	6.05615031400688	RPL27A/RPLP1/RPS23/F13A1/RPL23/RPL23A/RPS12/RPS18/RPS14/RPS24/RPL26/RPL19/RPL30/RPS11/RPL28/RPL14/RPS2/RPL15/RPL13A/CFD/RPS4X/RPL41/RPL10/RPL32/RPS7/RPS15/FAU/RPLP2/RPS27A/UBA52/RPL11/RPL13/RPL39/C1QA/RPS3A/RPL38/RPS15A/RPL37A/RPS16/RPS28/RPL18/RPL37/RPL29/RPL21/RPL10A/RPS13/RPL35/RPS19/RPL24/RPS9/RPS8/RPL34/RPL12/RPL7A/RPS25/RPL27/RPS20/RPL3/RPL9/RPL36A/RPS27/RPL35A/RPS3/RPL36/RPS6/RPL18A/RPS21/RPL5/RPLP0/RPL8/RPL22/C1QB/C7/RPL17/IL6ST/RPL7/RPS5/C1QC/RPS29/RPL31/CYBB/RPS10/RPL6/RPL4/FOS/JUN/RPL36AL/RPS17/RPSA/NRP1/FCGR2A/RPS27L/RPS26/RSL24D1/CCL2/TNFRSF1A/CXCL8/C2/TLR7/PIK3R1/C3AR1	21.6879179925224
Genetic Information Processing	Translation	hsa03010	Ribosome	88/657	222/9376	5.65694461584873	RPL27A/RPLP1/RPS23/RPL23/RPL23A/RPS12/RPS18/RPS14/RPS24/RPL26/RPL19/RPL30/RPS11/RPL28/RPL14/RPS2/RPL15/RPL13A/RPS4X/RPL41/RPL10/RPL32/RPS7/RPS15/FAU/RPLP2/RPS27A/UBA52/RPL11/RPL13/RPL39/RPS3A/RPL38/RPS15A/RPL37A/RPS16/RPS28/RPL18/RPL37/RPL29/RPL21/RPL10A/RPS13/RPL35/RPS19/RPL24/RPS9/RPS8/RPL34/RPL12/RPL7A/RPS25/RPL27/RPS20/RPL3/RPL9/RPL36A/RPS27/RPL35A/RPS3/RPL36/RPS6/RPL18A/RPS21/RPL5/RPLP0/RPL8/RPL22/RPL17/RACK1/RPL7/RPS5/RPS29/RPL31/RPS10/RPL6/RPL4/RPL36AL/RPS17/RPSA/MRPL51/RPS27L/MRPS6/RPS26/RSL24D1/MRPL32/MRPS26/MRPL41	19.275563823005
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	45/657	138/9376	4.65356362914433	UQCRB/COX6C/ATP5MG/ATP5F1E/NDUFA4/COX5B/COX7C/COX8A/COX4I1/ATP5F1A/COX6B1/NDUFA13/ATP5MC2/UQCR10/COX7A2/COX6A1/ATP5MC3/NDUFA2/COX7B/ATP5MF/ATP6V0C/NDUFA1/UQCR11/ATP6V1G1/ATP6V0E1/NDUFC2/ATP5PF/NDUFS5/NDUFA11/NDUFB11/ATP5ME/ATP6V0B/ATP5PD/NDUFB7/UQCRH/NDUFB4/UQCRQ/NDUFB10/ATP5F1D/ATP6V1B2/ATP6V1F/NDUFB8/MT-CYB/NDUFAB1/ATP5F1B	11.8686746157802
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	62/657	268/9376	3.30148345032827	RPS27A/UBA52/UQCRB/UBB/COX6C/ATP5F1E/NDUFA4/COX5B/COX7C/ITPR2/COX8A/COX4I1/ATP5F1A/COX6B1/NDUFA13/SLC25A6/ATP5MC2/UQCR10/COX7A2/GNAI1/COX6A1/TUBA1B/GNAS/ATP5MC3/NDUFA2/SLC39A13/COX7B/PSMB1/PSMD8/NDUFA1/UQCR11/CALM2/NDUFC2/GNAI2/ATP5PF/NDUFS5/NDUFA11/PSMA1/NDUFB11/PSMA2/ATP5PD/PSMA7/HSPA5/NDUFB7/UQCRH/NDUFB4/TUBB2B/PARK7/UQCRQ/CALM3/NDUFB10/BCL2L1/XBP1/ATP5F1D/NDUFB8/SOD1/MT-CYB/CALM1/SLC39A6/SLC25A5/NDUFAB1/ATP5F1B	10.492977134362
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	51/657	205/9376	3.55032854438133	COL3A1/COL1A1/CD36/UQCRB/COX6C/ATP5F1E/CYBB/NDUFA4/MMP2/CYBA/COX5B/COX7C/COL1A2/COX8A/COX4I1/ATP5F1A/COX6B1/NDUFA13/SLC25A6/ATP5MC2/UQCR10/COX7A2/COX6A1/ATP5MC3/NDUFA2/CTSD/COX7B/NDUFA1/UQCR11/NDUFC2/ATP5PF/NDUFS5/NDUFA11/NCF4/GAPDH/NDUFB11/ATP5PD/NDUFB7/UQCRH/PDK4/NDUFB4/UQCRQ/NDUFB10/PIK3R1/ATP5F1D/PPP1CA/NDUFB8/MT-CYB/SLC25A5/NDUFAB1/ATP5F1B	10.1344386899717
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	58/657	275/9376	3.00986854849869	C1QA/UQCRB/C1QB/C7/C1QC/COX6C/ATP5F1E/CYBB/NDUFA4/CYBA/COX5B/COX7C/ITPR2/COX8A/COX4I1/ATP5F1A/COX6B1/NDUFA13/SLC25A6/ATP5MC2/UQCR10/COX7A2/CREB3L1/COX6A1/TUBA1B/ATP5MC3/NDUFA2/COX7B/PSMB1/PSMD8/NDUFA1/UQCR11/NDUFC2/ATP5PF/NDUFS5/NDUFA11/NCF4/PSMA1/NDUFB11/PSMA2/ATP5PD/PSMA7/HSPA5/NDUFB7/UQCRH/NDUFB4/TUBB2B/UQCRQ/NDUFB10/PIK3R1/ATP5F1D/NDUFB8/SOD1/CSNK2B/MT-CYB/SLC25A5/NDUFAB1/ATP5F1B	9.28590910044186
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	66/657	388/9376	2.427529068399	UQCRB/WNT2/APOE/COX6C/ATP5F1E/CYBB/NDUFA4/COX5B/COX7C/ITPR2/COX8A/MME/COX4I1/ATP5F1A/AXIN2/COX6B1/NDUFA13/SLC25A6/ATP5MC2/UQCR10/COX7A2/FZD2/COX6A1/TUBA1B/ATP5MC3/NDUFA2/SLC39A13/COX7B/PSMB1/PSMD8/NDUFA1/UQCR11/CALM2/PTGS2/NDUFC2/ATP5PF/NDUFS5/NDUFA11/GAPDH/PSMA1/NDUFB11/PSMA2/ATP5PD/PSMA7/NDUFB7/APH1A/LRP1/UQCRH/NDUFB4/TUBB2B/UQCRQ/TNFRSF1A/CALM3/NDUFB10/PIK3R1/XBP1/ATP5F1D/NDUFB8/CSNK2B/MT-CYB/CALM1/SLC39A6/SLC25A5/NDUFAB1/ATP5F1B/FZD7	7.88323141297122
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	48/657	235/9376	2.91491304770232	UQCRB/RPS6/ACTB/COX6C/ACTG1/ATP5MG/ATP5F1E/NDUFA4/COX5B/COX7C/COX8A/COX4I1/ATP5F1A/COX6B1/NDUFA13/ATP5MC2/UQCR10/COX7A2/CREB3L1/COX6A1/GNAS/ATP5MC3/NDUFA2/COX7B/ATP5MF/ADCY3/NDUFA1/UQCR11/NDUFC2/ATP5PF/NDUFS5/NDUFA11/NDUFB11/ATP5ME/ATP5PD/NDUFB7/UQCRH/NDUFB4/UQCRQ/NDUFAF3/NDUFB10/ATP5F1D/SMARCD2/NDUFB8/COX16/MT-CYB/NDUFAB1/ATP5F1B	8.16058173831468
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	46/657	227/9376	2.89190620830232	HGF/UQCRB/COX6C/ATP5F1E/NDUFA4/CYBA/COX5B/COX7C/FOS/JUN/COX8A/COX4I1/ATP5F1A/COX6B1/NDUFA13/SLC25A6/ATP5MC2/UQCR10/COX7A2/COX6A1/ATP5MC3/NDUFA2/COX7B/NDUFA1/UQCR11/NDUFC2/ATP5PF/NDUFS5/NDUFA11/NDUFB11/ATP5PD/NDUFB7/UQCRH/GSTM3/NDUFB4/UQCRQ/NDUFB10/PIK3R1/ATP5F1D/NDUFB8/SOD1/MT-CYB/SLC25A5/GSTO1/NDUFAB1/ATP5F1B	7.92064778067271
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	54/657	308/9376	2.50204589930617	UQCRB/COX6C/ATP5F1E/NDUFA4/COX5B/COX7C/COX8A/COX4I1/ATP5F1A/COX6B1/NDUFA13/SLC25A6/ATP5MC2/UQCR10/COX7A2/GPX7/CREB3L1/COX6A1/CLTA/TUBA1B/AP2S1/ATP5MC3/NDUFA2/COX7B/PSMB1/PSMD8/NDUFA1/UQCR11/NDUFC2/ATP5PF/NDUFS5/NDUFA11/PSMA1/NDUFB11/PSMA2/POLR2L/TGM2/ATP5PD/PSMA7/NDUFB7/UQCRH/NDUFB4/TUBB2B/UQCRQ/NDUFB10/ATP5F1D/NDUFB8/SOD1/GPX3/AP2M1/MT-CYB/SLC25A5/NDUFAB1/ATP5F1B	7.35762739741263
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	60/657	368/9376	2.32678181457217	UQCRB/ACTB/COX6C/ACTG1/ATP5F1E/NDUFA4/NRG2/COX5B/COX7C/COX8A/COX4I1/ATP5F1A/COX6B1/NDUFA13/ATP5MC2/HNRNPA1/UQCR10/COX7A2/GPX7/COX6A1/TUBA1B/ATP5MC3/NDUFA2/COX7B/PSMB1/PFN1/PSMD8/NDUFA1/UQCR11/NDUFC2/ATP5PF/NDUFS5/NDUFA11/PSMA1/NDUFB11/PSMA2/ATP5PD/PSMA7/HSPA5/NDUFB7/UQCRH/NDUFB4/TPR/TUBB2B/UQCRQ/TNFRSF1A/MAP1LC3C/NDUFB10/BCL2L1/XBP1/ATP5F1D/NDUFB8/SOD1/GPX3/MT-CYB/HNRNPA2B1/SRSF3/NDUFAB1/ATP5F1B/HNRNPA3	7.12761470237748
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	35/657	157/9376	3.18141717321545	UQCRB/COX6C/NDUFA4/COX5B/COX7C/FOS/JUN/COX8A/COX4I1/COX6B1/NDUFA13/UQCR10/COX7A2/COX6A1/NDUFA2/COX7B/NDUFA1/UQCR11/NDUFC2/NDUFS5/NDUFA11/NDUFB11/NDUFB7/UQCRH/NDUFB4/ADIPOR1/UQCRQ/TNFRSF1A/CXCL8/NDUFB10/PIK3R1/XBP1/NDUFB8/MT-CYB/NDUFAB1	7.56626644182947
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	69/657	480/9376	2.05144596651446	RPS27A/UBA52/UQCRB/UBB/WNT2/COX6C/ATP5F1E/CYBB/NDUFA4/COX5B/COX7C/ITPR2/COX8A/COX4I1/ATP5F1A/AXIN2/COX6B1/NDUFA13/SLC25A6/ATP5MC2/UQCR10/COX7A2/GPX7/FZD2/COX6A1/TUBA1B/ATP5MC3/NDUFA2/COX7B/PSMB1/PSMD8/NDUFA1/UQCR11/CALM2/PTGS2/NDUFC2/ATP5PF/NDUFS5/NDUFA11/PSMA1/NDUFB11/PSMA2/ATP5PD/PSMA7/HSPA5/NDUFB7/SPTBN2/UQCRH/NDUFB4/TUBB2B/PARK7/UQCRQ/TNFRSF1A/MAP1LC3C/CALM3/NDUFB10/BCL2L1/XBP1/ATP5F1D/NDUFB8/SOD1/GPX3/CSNK2B/MT-CYB/CALM1/SLC25A5/NDUFAB1/ATP5F1B/FZD7	6.49150169832743
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	30/657	155/9376	2.76211518633083	CD36/CD14/ACTB/ACTG1/FCGR3A/HLA-C/CYBB/CYBA/HLA-B/CALR/FCGR2A/MRC1/TUBA1B/HLA-A/CTSL/ATP6V0C/SEC61G/ATP6V1G1/ATP6V0E1/NCF4/SEC61B/ATP6V0B/FCGR1A/CTSS/TUBB2B/CLEC7A/CORO1A/ATP6V1B2/ATP6V1F/HLA-E	6.07220068239214
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	15/657	51/9376	4.19733190079685	ACTB/ACTG1/GNAS/ATP6V0C/ARF1/ADCY3/SEC61G/ATP6V1G1/ATP6V0E1/SEC61B/ATP6V0B/KDELR2/KDELR1/ATP6V1B2/ATP6V1F	6.28468294249118
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	18/657	78/9376	3.29329118370214	C1QA/CD14/C1QB/C1QC/FOS/JUN/CFL1/LY96/GNAI1/CFL2/CALM2/GNAI2/PYCARD/C4BPB/CALM3/CXCL8/C2/CALM1	5.58273117803
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	19/657	87/9376	3.11663954932732	UQCRB/COX6C/COX5B/COX7C/COX8A/COX4I1/COX6B1/UQCR10/COX7A2/TNNT2/COX6A1/COX7B/UQCR11/SLC8A1/UQCRH/UQCRQ/TNNC1/MYL4/MT-CYB	5.44448788377013
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	34/657	227/9376	2.13749589309302	B2M/HLA-C/EIF4EBP1/PDGFRA/CCL3/ITPR2/HLA-B/CALR/GNAI1/CREB3L1/GNG5/GNAS/HLA-A/ADCY3/GNGT1/GNG10/CALM2/PTGS2/PTGER2/GNAI2/CCL4/CCR1/GNB2/CCL4L2/GNG2/IL1R1/CCL2/TNFRSF1A/CALM3/CXCL8/PIK3R1/HLA-E/CALM1/CCL3L1	4.76223624702638
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	24/657	149/9376	2.29867304097331	NDUFA4/ITPR2/NDUFA13/GNAI1/GABRE/GNG5/NDUFA2/ADCY3/GNGT1/NDUFA1/GNG10/PTGS2/NDUFC2/GNAI2/NDUFS5/NDUFA11/GNB2/NDUFB11/NDUFB7/GNG2/NDUFB4/NDUFB10/NDUFB8/NDUFAB1	4.38629344892954
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	23/657	142/9376	2.31148841297404	ACTB/ACTG1/MMP2/CYBA/FOS/JUN/GSTP1/BMP4/CTSL/CALM2/SUMO2/SDC1/KLF2/HSP90B1/GSTM3/IL1R1/CCL2/TNFRSF1A/CALM3/PIK3R1/CALM1/HSP90AB1/GSTO1	4.32263613056553
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	12/657	50/9376	3.42502283105023	CD36/HGF/HBB/HBA2/HBA1/CD81/GYPC/CR1/SDC1/LRP1/CCL2/CXCL8	4.71941439096249
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	33/657	250/9376	1.88376255707763	CD63/LGMN/VAMP8/NPC2/CTSC/CD68/LAMTOR5/CLTA/CD164/AP2S1/CTSD/CTSL/ATP6V0C/ATP6V1G1/ATP6V0E1/LAPTM5/ATP6V0B/MCOLN2/SLC29A1/BLOC1S1/CTSZ/CTSS/PSAP/NAGA/FUCA1/LAPTM4A/TLR7/LAMTOR4/ATP6V1B2/CTSB/ATP6V1F/AP2M1/HEXA	3.88776811696043
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/657	59/9376	2.90256172122901	GGT5/ANPEP/GPX4/HPGDS/GSTP1/GPX7/LAP3/PRDX6/GSTM3/GPX3/IDH1/GSTO1	4.02403451309337
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	21/657	140/9376	2.14063926940639	SPP1/RPS6/ITPR2/PDE3B/GNAI1/GNG5/ADCY3/GNGT1/GNG10/CALM2/GNAI2/GNB2/KLF2/GNG2/SLC8A1/MAP1LC3C/ACTA2/CALM3/JAG1/MYL4/CALM1	3.73254763618194
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	28/657	214/9376	1.86722428484047	B2M/HLA-C/FOS/JUN/ITPR2/ELOB/HLA-B/CALR/CFL1/GNAI1/GNG5/HLA-A/GNGT1/GNG10/CFL2/CALM2/SAMHD1/GNAI2/GNB2/GNG2/BST2/TNFRSF1A/CALM3/BCL2L1/PIK3R1/HLA-E/CALM1/RBX1	3.52272026702363
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	24/657	174/9376	1.96840392589094	MAN1A1/CALR/TMEM258/SEC61G/KRTCAP2/OSTC/SSR4/P4HB/SEC61B/HERPUD1/SSR2/HSPA5/HSP90B1/DDOST/SELENOS/DAD1/RPN2/UBXN4/TRAM1/XBP1/HSP90AB1/LMAN2/SAR1A/RBX1	3.53936241889672
Organismal Systems	Immune system	hsa04611	Platelet activation	19/657	126/9376	2.15196540310696	COL3A1/COL1A1/ACTB/FCER1G/VAMP8/ACTG1/MYL12A/COL1A2/ITPR2/PLA2G4A/FCGR2A/GNAI1/MYL12B/GNAS/ADCY3/GNAI2/GUCY1A1/PIK3R1/PPP1CA	3.57345918832525
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	19/657	130/9376	2.08575108301136	COL3A1/COL1A1/MMP2/FOS/JUN/COL1A2/GNAI1/CREB3L1/GNG5/GNAS/ADCY3/GNGT1/GNG10/GNAI2/GNB2/GNG2/EDNRB/ACTA2/PIK3R1	3.42184227113529
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/657	103/9376	2.21684325634319	COL3A1/COL1A1/SLC16A10/DPP4/COL8A2/COL15A1/COL6A1/COL14A1/COL1A2/MME/COL11A1/ELN/SLC38A2/COL16A1/SLC1A5/SLC8A1	3.40861621968264
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	16/657	103/9376	2.21684325634319	C1QA/C1QB/C1QC/FOS/CCL3/JUN/CALR/GNAI1/GNAS/GNAI2/IFNGR2/CCL2/TNFRSF1A/CXCL8/PIK3R1/CCL3L1	3.40861621968264
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	30/657	248/9376	1.72632199145677	CD14/S100A10/RPS3/ACTB/ACTG1/FOS/MYL12A/JUN/ARPC3/ELMO1/ARPC5/LY96/TUBA1B/MYL12B/ARF1/ARPC1B/PFN1/DYNLRB1/PYCARD/CASP4/GAPDH/HSP90B1/DYNLL1/TUBB2B/TNFRSF1A/CXCL8/DYNLT1/CYFIP2/SNX18/HSP90AB1	3.18201485445747
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	25/657	196/9376	1.82027148759047	RPS27A/UBA52/UBB/IL6ST/HLA-C/FOS/JUN/ITPR2/HLA-B/GNG5/HLA-A/GNGT1/GNG10/CALM2/PTGS2/CCR1/GNB2/GNG2/TNFRSF1A/MAP1LC3C/CALM3/CXCL8/PIK3R1/HLA-E/CALM1	3.18565906582681
Organismal Systems	Endocrine system	hsa04924	Renin secretion	12/657	69/9376	2.48190060221031	ITPR2/PDE3B/GNAI1/GNAS/CALM2/PTGER2/GNAI2/GUCY1A1/CALM3/PDE3A/CTSB/CALM1	3.39135885664503
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	9/657	44/9376	2.91905354919054	MAN1A1/TMEM258/KRTCAP2/OSTC/HEXD/DDOST/DAD1/RPN2/HEXA	3.50236214949827
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	14/657	88/9376	2.27037498270375	F13A1/CFD/F3/SERPINE2/C1QA/C1QB/C7/VTN/C1QC/VSIG4/CR1/C4BPB/C2/C3AR1	3.28660225984593
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	13/657	82/9376	2.2624642684783	B2M/LGMN/HLA-C/HSPA2/HLA-B/CALR/HLA-A/CTSL/HSPA5/CTSS/CTSB/HLA-E/HSP90AB1	3.15180740397454
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	7/657	31/9376	3.22246771738597	SRP14/SPCS2/SEC61G/SEC61B/SPCS1/HSPA5/TMEM208	3.40221409531618
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	27/657	233/9376	1.65371274031395	COL3A1/DCN/COL1A1/ACTB/FBLN1/COL6A1/ACTG1/FBLN2/LAMA2/COL1A2/COL11A1/ELN/TNNT2/VIM/SDC1/FBN2/TMEM43/SGCA/CSRP2/VCAN/SPTBN2/NEBL/TNNT1/TNNC1/SNTB1/MYL4/FBN1	2.77367475576474
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	24/657	200/9376	1.71251141552511	RPS3/ACTB/ACTG1/MYO10/FOS/JUN/ARPC3/ARPC5/FCGR2A/TUBA1B/TMBIM6/ARF1/ARPC1B/LPAR1/PYCARD/CASP4/GAPDH/NCL/HCLS1/IL1R1/TUBB2B/TNFRSF1A/CXCL8/CYFIP2	2.79585797594317
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	14/657	97/9376	2.05972163379309	FOS/GNAI1/GNG5/GNAS/ADCY3/GNGT1/GNG10/CALM2/GNAI2/GNB2/GNG2/GUCY1A1/CALM3/CALM1	2.87979825552609
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/657	78/9376	2.19552745580143	EEF1A1/FCGR3A/CYBB/CYBA/FOS/JUN/FCGR2A/CR1/PTGS2/NCF4/IFNGR2/FCGR1A	2.91036238621863
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/657	42/9376	2.7182720881351	FTL/FTH1/CYBB/SLC40A1/GPX4/PCBP1/NCOA4/MAP1LC3C	3.06349846091678
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/657	89/9376	2.08451764062046	GABARAP/GNAI1/GABRE/GNG5/SLC38A2/ADCY3/GNGT1/GNG10/GNAI2/GABARAPL2/GNB2/GLUL/GNG2	2.82181725822003
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	18/657	142/9376	1.80899093189273	TYROBP/FCGR3A/CYBA/FOS/JUN/ITPR2/FCGR2A/CSF1R/SOCS1/JUNB/NCF4/IFNGR2/FCGR1A/SIRPA/IL1R1/TNFRSF1A/LILRB5/PIK3R1	2.66641580429167
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	28/657	253/9376	1.57939129231565	RPS27A/UBA52/CD14/ACTB/UBB/ACTG1/MYL12A/JUN/ITPR2/ARPC3/ELMO1/ARPC5/MYL12B/ARF1/ARPC1B/PFN1/PYCARD/CASP4/HCLS1/CALCOCO2/IL1R1/TNFRSF1A/MAP1LC3C/CXCL8/BCL2L1/PIK3R1/SEPTIN7/RBX1	2.56447441856259
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/657	95/9376	1.95286389489706	FOS/CCL3/JUN/CTSL/ATP6V0C/ATP6V1G1/ATP6V0E1/ATP6V0B/CCL2/CXCL8/ATP6V1B2/ATP6V1F/CCL3L1	2.56230174174498
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	21/657	181/9376	1.65574308130881	CD14/FCER1G/FCGR3A/LSP1/FCGR2A/MRC1/CTSD/ATP6V0C/CR1/CALM2/CEBPB/ATP6V0B/IFNGR2/FCGR1A/CTSS/TNFRSF1A/CLEC7A/CALM3/CORO1A/TLR1/CALM1	2.4452998537172
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	23/657	204/9376	1.60897722863879	DCN/COL1A1/LUM/GPC3/HGF/CD63/RPS6/ACTB/WNT2/VTN/IGF2/ACTG1/MMP2/COL1A2/ITPR2/FZD2/CTSL/SDC1/TWIST1/HCLS1/PIK3R1/PPP1CA/FZD7	2.41389901926955
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	24/657	216/9376	1.58565871807881	CD36/CD14/CYBB/CYBA/HSPA2/FOS/CCL3/JUN/LY96/CALM2/PYCARD/NCF4/HSPA5/HSP90B1/CCL2/TNFRSF1A/CALM3/CXCL8/BCL2L1/PIK3R1/XBP1/CALM1/CCL3L1/HSP90AB1	2.39033480650808
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	17/657	139/9376	1.74536535155437	MMP2/FOS/JUN/ITPR2/GNAI1/CREB3L1/GNAS/CTSD/ADCY3/CALM2/GNAI2/KRT18/HSP90B1/CALM3/PIK3R1/CALM1/HSP90AB1	2.4302229234159
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	13/657	98/9376	1.89308234709409	MARCKS/FCGR3A/MYO10/PLPP3/ARPC3/CFL1/ARPC5/PLA2G4A/FCGR2A/ARPC1B/CFL2/FCGR1A/PIK3R1	2.43956471344419
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	14/657	110/9376	1.816299986163	DCN/PITX2/BMP5/INHBB/FMOD/FST/BMP4/BAMBI/ID2/ID3/LEFTY2/SMAD6/FBN1/RBX1	2.3639319363043
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	18/657	154/9376	1.66803059953745	ACTB/ACTG1/MYL6/FOS/JUN/ITPR2/PLA2G4A/GNAI1/GNAS/EEF2/ADCY3/CALM2/PTGS2/GNAI2/GUCY1A1/CALM3/PPP1CA/CALM1	2.29445287171696
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	16/657	133/9376	1.71680342408533	FOS/ITPR2/GNAI1/CREB3L1/GNG5/GNAS/GNGT1/GNG10/CALM2/GNAI2/GNB2/GNG2/CALM3/COMT/PPP1CA/CALM1	2.28535882950151
Human Diseases	Substance dependence	hsa05032	Morphine addiction	12/657	91/9376	1.88188067640122	PDE3B/GNAI1/GABRE/GNG5/GNAS/ADCY3/GNGT1/GNG10/GNAI2/GNB2/GNG2/PDE3A	2.32046249164634
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	18/657	157/9376	1.63615740336794	IGFBP3/CCND2/HLA-C/EIF4EBP1/GATA4/ITPR2/HLA-B/SLC25A6/HLA-A/GADD45B/CALM2/CALM3/CXCL8/PIK3R1/PPP1CA/HLA-E/CALM1/SLC25A5	2.20651807087835
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	26/657	250/9376	1.48417656012177	DAB2/FOLR2/HLA-C/PDGFRA/HLA-B/ARPC3/FGFR2/ARPC5/CLTA/AP2S1/HLA-A/RAB11FIP1/SNX3/ARF1/ARPC1B/SNX2/SH3GL3/CHMP5/CHMP2A/SNX6/VPS28/WWP1/WASHC4/HLA-E/NEDD4/AP2M1	2.12994562662337
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	16/657	137/9376	1.66667777666678	ACTB/ACTG1/FOS/JUN/CTSC/ITPR2/TUBA1B/CTSD/CTSL/GADD45B/CTSZ/CTSS/TNFRSF1A/BCL2L1/PIK3R1/CTSB	2.15773826114241
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	13/657	105/9376	1.76687685728782	RPS27A/UBA52/UBB/TOMM7/JUN/BNIP3L/GABARAP/GABARAPL2/TOMM20/CALCOCO2/MAP1LC3C/BCL2L1/CSNK2B	2.16916193653452
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/657	76/9376	1.87775374509333	ACTB/ACTG1/ITPR2/GNAI1/GNAS/ADCY3/CALM2/GNAI2/CALM3/CALM1	2.10898260246235
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	8/657	56/9376	2.03870406610133	ST6GAL2/MAN1A1/TMEM258/KRTCAP2/OSTC/DDOST/DAD1/RPN2	2.13999556440892
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/657	56/9376	2.03870406610133	EEF1A1/CD14/EEF1G/ARF1/CR1/PYCARD/CXCL8/SAR1A	2.13999556440892
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	13/657	109/9376	1.70203733958918	SPP1/CD14/FOS/CCL3/JUN/LY96/CCL4/CCL4L2/CXCL8/TLR1/TLR7/PIK3R1/CCL3L1	2.02366613184369
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	32/657	333/9376	1.37138051293302	SPP1/COL1A1/WNT2/VTN/COL6A1/CCND2/HLA-C/EIF4EBP1/LAMA2/LAMC3/COL1A2/HLA-B/AXIN2/RBPJ/FZD2/CREB3L1/GNAS/HLA-A/ATP6V0C/PTGS2/LLGL2/ATP6V1G1/ATP6V0E1/HEYL/ATP6V0B/TNFRSF1A/JAG1/PIK3R1/ATP6V1B2/ATP6V1F/HLA-E/FZD7	1.89417433206163
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/657	28/9376	2.54838008262666	ATP6V0C/ATP6V1G1/ATP6V0E1/ATP6V1B2/ATP6V1F	2.25233105114919
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/657	89/9376	1.76382261898654	PDGFRA/GJA1/ITPR2/GNAI1/TUBA1B/GNAS/ADCY3/GNAI2/LPAR1/GUCY1A1/TUBB2B	1.98739768515148
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/657	100/9376	1.71251141552511	CXCL14/IL6ST/CCL3/CSF1R/IL18R1/CCL4/CCR1/CCL4L2/CCL2/TNFRSF1A/CXCL8/CCL3L1	1.96628488588199
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	10/657	79/9376	1.80644664084928	CLTA/AP2S1/ATP6V0C/ATP6V1G1/ATP6V0E1/ATP6V0B/ATP6V1B2/ATP6V1F/VAMP2/AP2M1	1.97584445074873
Organismal Systems	Sensory system	hsa04744	Phototransduction	5/657	29/9376	2.46050490736367	GNGT1/CALM2/CALM3/RGS9/CALM1	2.16222498949072
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	12/657	101/9376	1.69555585695556	WNT2/GNAI1/FZD2/CREB3L1/GNAS/ADCY3/CALM2/GNAI2/EDNRB/CALM3/CALM1/FZD7	1.92917099569192
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/657	59/9376	1.935041147486	PDE3B/GNAI1/GNAS/ADCY3/PTGS2/GNAI2/CIDEC/PIK3R1	1.97766926910289
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/657	70/9376	1.83483365949119	ACTB/ACTG1/HLA-C/LAMA2/HLA-B/HLA-A/SGCA/SNTB1/HLA-E	1.92443138483457
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	12/657	103/9376	1.66263244225739	COL3A1/COL1A1/CD14/LAMA2/LAMC3/COL1A2/GNAS/PRDX1/IL1R1/SERPINB9/CXCL8/PIK3R1	1.85616321460671
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	13/657	116/9376	1.59932818978639	ITPR2/PLA2G4A/GNAI1/GNG5/GNAS/SLC38A2/ADCY3/GNGT1/GNG10/GNAI2/GNB2/GLUL/GNG2	1.7828844243911
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	22/657	224/9376	1.40160904544466	B2M/CCND2/HLA-C/FOS/JUN/HLA-B/CALR/NRP1/SLC25A6/TSPO/CREB3L1/HLA-A/ADCY3/MSX1/IL1R1/ANAPC11/TNFRSF1A/BCL2L1/PIK3R1/HLA-E/RANBP1/SLC25A5	1.66995386571171
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/657	52/9376	1.92108652382625	CD36/PLTP/APOE/NPC2/TSPO/LRP1/APOC1	1.82825155652658
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/657	63/9376	1.81218139209007	PTGDS/GGT5/GPX4/HPGDS/PLA2G5/PLA2G2A/PLA2G4A/PTGS2	1.77547062989882
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	17/657	166/9376	1.46148062569914	GATA4/ITPR2/PDE3B/SLC25A6/GNAI1/CREB3L1/ADCY3/CALM2/GNAI2/GUCY1A1/SLC8A1/EDNRB/CALM3/PDE3A/PPP1CA/CALM1/SLC25A5	1.64669317640013
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	19/657	193/9376	1.40491005591439	CXCL14/CCL3/ELMO1/GNAI1/GNG5/ADCY3/GNGT1/GNG10/GNAI2/CCL4/CCR1/GNB2/CCL4L2/GNG2/CCL2/CXCL8/PIK3R1/CCL3L1/DOCK2	1.5601986905549
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/657	99/9376	1.58565871807881	ITPR2/PLA2G4A/GNAS/ADCY3/CALM2/PTGER2/IL1R1/CALM3/PIK3R1/PPP1CA/CALM1	1.60802729283681
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	11/657	99/9376	1.58565871807881	CFD/C1QA/C1QB/C1QC/FCGR3A/FCGR2A/FCGR1A/KRT18/C2/C3AR1/PTAFR	1.60802729283681
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/657	78/9376	1.64664559185107	ACTB/ACTG1/ARPC3/ELMO1/ARPC5/CLTA/ARPC1B/HCLS1/PIK3R1	1.57417799031295
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/657	16/9376	2.67579908675799	NAGA/ST3GAL1/HEXA	1.84153085766056
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/657	46/9376	1.86142545165773	POMP/PSMB1/PSMD8/PSMA1/PSMA2/PSMA7	1.60764730710936
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	32/657	362/9376	1.26151853814005	SPP1/COL1A1/HGF/RPS6/PRLR/VTN/COL6A1/IGF2/CCND2/EIF4EBP1/PDGFRA/LAMA2/LAMC3/COL1A2/FGFR2/CSF1R/CREB3L1/GNG5/GNGT1/GNG10/LPAR1/ARTN/GNB2/YWHAB/HSP90B1/GNG2/NRTN/LPAR6/BCL2L1/PIK3R1/CSH1/HSP90AB1	1.39294180445708
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	18/657	187/9376	1.3736722584426	CYBB/CYBA/JUN/ITPR2/CARD18/GABARAP/CARD16/GABARAPL2/PYCARD/CASP4/CCL2/MAP1LC3C/GPSM3/CXCL8/BCL2L1/CTSB/TXNIP/HSP90AB1	1.416812952527
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	12/657	115/9376	1.48914036132619	FOS/ITPR2/GNAI1/CREB3L1/GNG5/ADCY3/GNGT1/GNG10/GNAI2/GNB2/GNG2/PIK3R1	1.4487333650476
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/657	69/9376	1.65460040147354	FOS/JUN/CREB3L1/GNAS/CALM2/CALM3/PPP1CA/CALM1	1.49806597405352
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/657	105/9376	1.49504964847431	CD14/LY96/GADD45B/PTGS2/CCL4/CCL4L2/IL1R1/TNFRSF1A/CXCL8/BCL2L1/CSNK2B	1.40028068908361
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/657	105/9376	1.49504964847431	FCER1G/JUN/ITPR2/LSP1/CALM2/PTGS2/PYCARD/CLEC7A/CALM3/PIK3R1/CALM1	1.40028068908361
NA	NA	hsa04518	Integrin signaling	15/657	154/9376	1.39002549961454	SPP1/COL1A1/HGF/ACTB/VTN/COL6A1/ACTG1/CCND2/PDGFRA/LAMA2/LAMC3/COL1A2/PIK3R1/FERMT1/FBN1	1.33960200064647
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/657	71/9376	1.6079919394602	JUN/ATP6V0C/ATP6V1G1/ATP6V0E1/ATP6V0B/CXCL8/ATP6V1B2/ATP6V1F	1.41157445809217
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/657	49/9376	1.74746062808685	JUN/GNAI1/CREB3L1/GNAS/GNAI2/RGS9	1.43995976478984
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/657	18/9376	2.37848807711821	HEXD/FUCA1/HEXA	1.60687735474578
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/657	61/9376	1.63764752850762	FTL/FTH1/SLC40A1/HMOX2/SLC8A1/ATOX1/ATP7B	1.37147897049289
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	15/657	157/9376	1.36346450280662	CD36/C1QA/C1QB/C1QC/CALR/ELMO1/PTGS2/PTGER2/CEBPB/TYRO3/LRP1/SIRPA/MERTK/STAB1/BSG	1.26068012306344
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	13/657	134/9376	1.38449305981508	MYL6/ITPR2/PLA2G5/PLA2G2A/PLA2G4A/GNAS/ADCY3/CALM2/GUCY1A1/ACTA2/CALM3/PPP1CA/CALM1	1.23053198389649
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	12/657	122/9376	1.40369788157796	IGFBP3/FOS/ITPR2/GNAI1/CREB3L1/GNAS/SOCS1/JUNB/ADCY3/GNAI2/PIK3R1/CSH1	1.23198841040499
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/657	10/9376	2.85418569254186	PAPSS2/MPST	1.61031609253124
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/657	75/9376	1.52223236935566	IGFBP3/CCND2/CCNG2/GADD45B/SESN1/BCL2L1/CCNG1/SIVA1	1.2464204926451
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/657	75/9376	1.52223236935566	ITPR2/GPX7/CREB3L1/GNAS/ADCY3/HSPA5/HSP90B1/GPX3	1.2464204926451
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/657	52/9376	1.64664559185107	HSD17B2/PLA2G4A/GNAS/ADCY3/PTGS2/HSD17B1	1.28351764925592
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	10/657	101/9376	1.41296321412963	COL3A1/COL1A1/F3/CYBB/MMP2/JUN/COL1A2/CCL2/CXCL8/PIK3R1	1.14538127602526
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/657	138/9376	1.34436282619725	ACTB/ACTG1/FOS/JUN/ARPC3/ELMO1/ARPC5/FCGR2A/ARPC1B/PYCARD/CCL2/CXCL8/PIK3R1	1.11866953713431
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	9/657	89/9376	1.44312759735262	SPP1/COL1A1/CD36/VTN/COL6A1/LAMA2/LAMC3/COL1A2/SDC1	1.15297811208293
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/657	43/9376	1.65941028636154	CD36/PLPP3/PLA2G5/PLA2G2A/AGPAT2	1.18963654383532
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	11/657	115/9376	1.36504533121567	ITPR2/PLA2G4A/GNAI1/GNG5/GNAS/GNGT1/GNG10/PTGS2/GNAI2/GNB2/GNG2	1.08118935361035
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/657	116/9376	1.35327769905002	ACTB/ACTG1/CYBB/MMP2/CYBA/MYL12A/GNAI1/MYL12B/GNAI2/NCF4/PIK3R1	1.05093222353766
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/657	44/9376	1.62169641621696	CREB3L1/GNAS/ADCY3/DYNLL1/VAMP2	1.13462492881215
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	16/657	180/9376	1.26852697446305	B2M/HLA-C/EIF4EBP1/HLA-B/CALR/HLA-A/IFNGR2/SRSF9/BST2/CCL2/TNFRSF1A/BCL2L1/PIK3R1/PPP1CA/HLA-E/SRSF3	0.998526681322626
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/657	80/9376	1.42709284627093	HGF/RPS6/EIF4EBP1/PDGFRA/NRG2/FGFR2/BCL2L1/PIK3R1	1.05306266881234
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	15/657	168/9376	1.27419004131333	FTL/FTH1/CYBB/PPIA/SLC25A6/PLA2G4A/PYCARD/IFNGR2/GLUL/CHMP5/CHMP2A/TNFRSF1A/HMGB1/HSP90AB1/SLC25A5	0.984370628244416
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/657	105/9376	1.35913604406755	ACTB/ACTG1/LAMA2/TNNT2/GNAS/ADCY3/SGCA/SLC8A1/TNNC1/SNTB1	1.01584006535816
Cellular Processes	Cell motility	hsa04814	Motor proteins	17/657	194/9376	1.25054527766009	ACTB/ACTG1/MYO10/MYL6/MYL12A/TNNT2/TUBA1B/MYL12B/DYNLRB1/DYNLL1/TNNT1/TUBB2B/TNNC1/ACTA2/DYNLT1/MYL4/KIF20B	0.967951119298022
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/657	93/9376	1.38105759316541	MMP2/JUN/ITPR2/PLA2G4A/GNAS/ADCY3/CALM2/CALM3/CALM1	1.0137314102878
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/657	93/9376	1.38105759316541	ITPR2/GNAS/ADCY3/CALM2/GUCY1A1/LYZ/CALM3/VAMP2/CALM1	1.0137314102878
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	15/657	169/9376	1.26665045527005	RPS27A/UBA52/UBB/VAMP8/GABARAP/CTSD/CTSL/GABARAPL2/DAPK1/CALCOCO2/MAP1LC3C/HMGB1/BCL2L1/PIK3R1/CTSB	0.960199762910371
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	17/657	195/9376	1.24413222495414	ACTB/ACTG1/FCGR3A/CYBB/CYBA/SLC25A6/FCGR2A/CLCN5/CR1/CASP4/NCF4/FCGR1A/CLEC7A/HMGB1/TLR7/PIK3R1/SLC25A5	0.945654307907458
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	13/657	144/9376	1.28834770843903	WNT2/IL6ST/INHBB/AXIN2/FGFR2/FZD2/BMP4/KLF4/ID2/ID3/PIK3R1/LEFTY2/FZD7	0.957160651471624
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	14/657	157/9376	1.27256686928618	BMP5/ACTB/WNT2/ACTG1/CCND2/AXIN2/FZD2/BMP4/LLGL2/SNAI2/YWHAB/ID2/PPP1CA/FZD7	0.945400807125143
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/657	119/9376	1.31916145453615	FOS/JUN/IL18R1/CREB3L1/JUNB/PTGS2/CEBPB/CCL2/TNFRSF1A/JAG1/PIK3R1	0.961797776267703
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	15/657	170/9376	1.25919957023905	HGF/ACTB/WNT2/IGF2/ACTG1/AXIN2/GSTP1/FZD2/GADD45B/GSTM3/BCL2L1/PIK3R1/SMARCD2/GSTO1/FZD7	0.93617758096222
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	9/657	94/9376	1.36636549111046	S100A9/FOS/JUN/PTGS2/CEBPB/HSP90B1/CCL2/CXCL8/HSP90AB1	0.979924663662677
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/657	60/9376	1.42709284627093	ITPR2/PLA2G4A/GNAI1/GNAS/GNAI2/GUCY1A1	0.910999558586506
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	13/657	149/9376	1.24511456386054	FCER1G/PDGFRA/PLPP3/PLA2G4A/GNAS/ARF1/ADCY3/LPAR1/PTGFR/AGPAT2/LPAR6/CXCL8/PIK3R1	0.827879205756773
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	17/657	203/9376	1.19510238357664	SPP1/COL1A1/HGF/ACTB/VTN/COL6A1/ACTG1/CCND2/PDGFRA/LAMA2/MYL12A/LAMC3/JUN/COL1A2/MYL12B/PIK3R1/PPP1CA	0.771418201165373
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/657	14/9376	2.03870406610133	CHST2/ST3GAL1	1.06759496107562
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	19/657	232/9376	1.16873983099774	TMSB4X/ACTB/C7/IQGAP2/ACTG1/PDGFRA/MYL12A/ARPC3/FGFR2/CFL1/ARPC5/MYL12B/ARPC1B/PFN1/CFL2/LPAR1/PIK3R1/PPP1CA/CYFIP2	0.714378668094465
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/657	26/9376	1.64664559185107	PLA2G5/PLA2G2A/PLA2G4A	0.906321273551809
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/657	63/9376	1.35913604406755	WNT2/AXIN2/FZD2/BMP4/GADD45B/FZD7	0.785090011406312
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	13/657	154/9376	1.2046887663326	GNAI1/TNNT2/CREB3L1/GNAS/ADCY3/CALM2/GNAI2/SLC8A1/TNNC1/CALM3/PPP1CA/MYL4/CALM1	0.703034753266137
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/657	15/9376	1.90279046169457	ST3GAL1/HEXA	0.96052009026286
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/657	51/9376	1.39911063359895	ENPP2/PLPP3/PLA2G5/PLA2G2A/PLA2G4A	0.784492779908475
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/657	39/9376	1.46368497053429	HLA-C/HLA-B/HLA-A/HLA-E	0.796501554169455
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	14/657	170/9376	1.17525293222312	ACTB/ACTG1/GATA4/MYL6/MYL12A/JUN/ARPC3/ARPC5/TUBA1B/MYL12B/ARPC1B/LLGL2/HCLS1/NEDD4	0.632978928143506
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	12/657	144/9376	1.18924403855911	ITPR2/SLC25A6/RBPJ/PSMB1/PSMD8/PSMA1/PSMA2/PSMA7/SPTBN2/PIK3R1/XBP1/SLC25A5	0.62818930732947
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/657	53/9376	1.34631400591597	CLTA/AP2S1/GNAS/SLC8A1/AP2M1	0.694009048512609
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/657	158/9376	1.17419031655203	RPS6/WNT2/EIF4EBP1/LAMTOR5/FZD2/ATP6V1G1/TNFRSF1A/PRR5/PIK3R1/LAMTOR4/ATP6V1B2/ATP6V1F/FZD7	0.606134751516431
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/657	17/9376	1.67893276031874	INMT/PAPSS2	0.769079944422662
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/657	17/9376	1.67893276031874	CA8/GLUL	0.769079944422662
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/657	55/9376	1.29735713297357	PLPP3/CERS2/PSAP/HEXA/DEGS1	0.607104477220337
NA	NA	hsa04517	IgSF CAM signaling	23/657	299/9376	1.09776372790071	ACTB/CADM3/ACTG1/MYL6/MYL12A/ARPC3/NRP1/MTSS1/PMP22/ARPC5/TUBA1B/MYL12B/PTPRD/ARPC1B/SLIT2/PLXNA2/CLMP/DYNLL1/SPTBN2/TUBB2B/PIK3R1/CADM1/CD84	0.471603657085125
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/657	30/9376	1.42709284627093	PLA2G5/PLA2G2A/PLA2G4A	0.64313925806319
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/657	110/9376	1.16762141967621	RPS6/CYBB/EIF4EBP1/ELOB/TIMP1/GAPDH/IFNGR2/PIK3R1/RBX1	0.485416677567046
NA	NA	hsa04081	Hormone signaling	17/657	219/9376	1.10778896742492	SLC16A10/PRLR/IGF2/SLC40A1/GNAI1/GNG5/GNAS/ADCY3/GNGT1/GNG10/GNAI2/GNB2/GNG2/VIPR2/ADIPOR1/PIK3R1/CSH1	0.443052045588395
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/657	44/9376	1.29735713297357	HLA-C/HLA-B/HLA-A/HLA-E	0.542690623640622
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/657	125/9376	1.14167427701674	FCER1G/GNAI1/CTSD/GNAI2/CERS2/S1PR5/TNFRSF1A/PIK3R1/DEGS1/S1PR2	0.437710188000991
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/657	71/9376	1.20599395459515	PRLR/CCND2/FOS/SOCS1/PIK3R1/CISH	0.478256019456566
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/657	98/9376	1.1649737520579	ITPR2/CREB3L1/GNAS/ADCY3/CALM2/CALM3/CALM1/KCNK3	0.450646175545272
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/657	112/9376	1.146771037182	LAMA2/LAMC3/LY96/GNAI1/SOCS1/GNAI2/IFNGR2/TNFRSF1A/BCL2L1	0.428928679563528
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/657	45/9376	1.26852697446305	HLA-C/HLA-B/HLA-A/HLA-E	0.495638535346254
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/657	99/9376	1.15320634042095	SLC22A3/EIF4EBP1/PDGFRA/FOS/JUN/PLPP3/PLA2G4A/PIK3R1	0.420654502746406
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/657	99/9376	1.15320634042095	ACTB/ACTG1/LAMA2/TNNT2/SGCA/SLC8A1/TNNC1/SNTB1	0.420654502746406
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/657	86/9376	1.16158720045308	ACTB/ACTG1/GJA1/LAMA2/SGCA/SLC8A1/SNTB1	0.413221880245726
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/657	100/9376	1.14167427701674	CD36/CD14/ANPEP/MME/CSF1R/CR1/FCGR1A/IL1R1	0.390971966969785
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	18/657	238/9376	1.07931391734776	HGF/IGF2/PDGFRA/PLA2G5/FGFR2/PLA2G2A/PLA2G4A/CSF1R/GNG5/GNGT1/GNG10/CALM2/GNB2/GNG2/CALM3/BCL2L1/PIK3R1/CALM1	0.340210165496595
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	12/657	155/9376	1.10484607453233	WNT2/ITPR2/AXIN2/GNAI1/FZD2/CREB3L1/GNAS/ADCY3/GNAI2/KCNK3/AIP/FZD7	0.361296701974984
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/657	46/9376	1.24095030110516	FTL/FTH1/BLVRB/HMOX2	0.449676872181391
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/657	33/9376	1.29735713297357	VAMP8/VAMP5/VAMP2	0.469707116757233
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	16/657	212/9376	1.07705120473278	HGF/ACTB/ACTG1/PDGFRA/FGFR2/CSF1R/GNAI1/GNAS/ADCY3/PFN1/CALM2/GNAI2/LPAR1/CALM3/PIK3R1/CALM1	0.31148691529385
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	11/657	143/9376	1.09776372790071	C1QA/C1QB/C7/C1QC/FCGR3A/FCGR2A/SSB/SNRPB/FCGR1A/C2/SNRPD3	0.323377157103413
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/657	75/9376	1.14167427701674	GSTP1/GSTM3/ATP7B/BCL2L1/PIK3R1/GSTO1	0.338136301991817
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/657	62/9376	1.15088132763785	RBPJ/HEYL/APH1A/JAG1/CIR1	0.327188634288097
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/657	76/9376	1.126652247056	PDGFRA/GADD45B/CALM2/CALM3/PIK3R1/CALM1	0.30430788486748
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	16/657	217/9376	1.05223435669746	EIF4EBP1/FOS/JUN/GNAI1/CREB3L1/GNAS/ADCY3/GNAI2/KLF4/HSP90B1/GSTM3/JAG1/PIK3R1/AIP/HSP90AB1/GSTO1	0.213696334084673
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/657	133/9376	1.07300214005333	TYROBP/FCER1G/HCST/FCGR3A/HLA-C/HLA-B/HLA-A/IFNGR2/PIK3R1/HLA-E	0.232750123307897
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/657	106/9376	1.07705120473278	FOLR2/PDGFRA/FGFR2/GSTP1/CREB3L1/HSP90B1/PIK3R1/HSP90AB1	0.218991613397538
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	15/657	205/9376	1.04421427775922	B2M/CCND2/HLA-C/JUN/HLA-B/CALR/RBPJ/HLA-A/VIM/GADD45B/PSMD8/PIK3R1/HLA-E/NEDD4/CIR1	0.175697710853505
Human Diseases	Substance dependence	hsa05034	Alcoholism	14/657	191/9376	1.04603664124571	GNAI1/CREB3L1/GNG5/GNAS/GNGT1/GNG10/CALM2/GNAI2/GNB2/SLC29A1/GNG2/CALM3/PPP1CA/CALM1	0.176447584814328
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	8/657	107/9376	1.06698530562312	ITPR2/PDE3B/CREB3L1/GNAS/CALM2/CALM3/PPP4C/CALM1	0.19128899044202
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	7/657	93/9376	1.07415590579532	ACTB/ACTG1/MYL12A/MYL12B/HEG1/SNAI2/CSNK2B	0.197277714212688
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	13/657	178/9376	1.04225882031023	SERPINF1/WNT2/RSPO2/CCND2/JUN/AXIN2/FZD2/ANKRD6/BAMBI/FRZB/CSNK2B/FZD7/RBX1	0.156248426286253
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/657	65/9376	1.09776372790071	ITPR2/CREB3L1/GNAS/ADCY3/KCNK3	0.217105713485862
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/657	37/9376	1.15710230778724	HBB/HBA2/HBA1	0.262825938111326
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/657	37/9376	1.15710230778724	GADD45B/TPR/NCOA4	0.262825938111326
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/657	23/9376	1.24095030110516	POLD4/SSBP1	0.31757836489304
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/657	23/9376	1.24095030110516	ANPEP/MME	0.31757836489304
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	10/657	138/9376	1.03412525092096	ITPR2/ADCY3/CALM2/YWHAB/ANAPC11/CALM3/PPP1CA/CALM1/SMC3/RBX1	0.11085656101126
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	10/657	138/9376	1.03412525092096	RPS6/EIF4EBP1/PDE3B/SOCS1/CALM2/CALM3/TRIP10/PIK3R1/PPP1CA/CALM1	0.11085656101126
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/657	67/9376	1.06499466139622	ITPR2/CALM2/CALM3/PPP1CA/CALM1	0.146554296774853
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/657	82/9376	1.04421427775922	GSTP1/NME2/NME4/GSTM3/UPP1/GSTO1	0.110383233397056
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	16/657	226/9376	1.01033121859889	FOS/JUN/PDE3B/GNAI1/CREB3L1/GNAS/ADCY3/CALM2/PTGER2/GNAI2/VIPR2/CALM3/PDE3A/PIK3R1/PPP1CA/CALM1	0.0431549092421046
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/657	68/9376	1.04933297519921	CD14/EIF4EBP1/CSF1R/FCGR1A/PIK3R1	0.112072371297962
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/657	54/9376	1.05710581205254	ADI1/MPST/AHCYL1/MAT2B	0.115520118680788
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/657	54/9376	1.05710581205254	HLA-C/HLA-B/HLA-A/HLA-E	0.115520118680788
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/657	83/9376	1.03163338284645	SAMHD1/PYCARD/CCL4/CCL4L2/POLR2L/PCBP1	0.0794587446092411
Genetic Information Processing	Transcription	hsa03040	Spliceosome	17/657	243/9376	0.998377711382954	HNRNPA1/HNRNPK/SNRPD2/SRSF9/SNRPB/PCBP1/SNRPG/LSM3/CDC5L/SYF2/SNU13/SNRPE/SNRPF/SNRPB2/SNRPD3/SRSF3/HNRNPA3	-0.00703330600406652
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	7/657	99/9376	1.00905554786833	MMP2/FOS/JUN/GNAS/ADCY3/JAG1/PIK3R1	0.0248635727162704
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/657	70/9376	1.01935203305066	HPGDS/GSTP1/PTGS2/GSTM3/GSTO1	0.0446096768375988
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/657	70/9376	1.01935203305066	HGF/JUN/ELOB/PIK3R1/RBX1	0.0446096768375988
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	14/657	201/9376	0.993995017303134	CD14/IGFBP3/CCND2/MAF/PROM1/CSF1R/NUPR1/GADD45B/CEBPB/FCGR1A/ID2/CXCL8/BCL2L1/HMGA2	-0.0236233637232379
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/657	41/9376	1.04421427775922	MMP2/DAPK1/CXCL8	0.077881137598078
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/657	173/9376	0.989890991633014	ACTB/ACTG1/SLC25A6/PYCARD/IFNGR2/CALCOCO2/CCL2/TNFRSF1A/CXCL8/TLR7/PIK3R1/SLC25A5	-0.0368384951255259
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	10/657	144/9376	0.991036698799256	C1QA/CD14/C1QB/C1QC/LY96/ADIPOR1/TNFRSF1A/CXCL8/C2/C3AR1	-0.0297533809548361
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/657	115/9376	0.992760240884124	NACA/FOS/ITPR2/GNAI1/CREB3L1/GNAS/ADCY3/GNAI2	-0.0214426807013835
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/657	71/9376	1.00499496216263	PDGFRA/FGFR2/SLC1A5/PIK3R1/IDH1	0.0115968001387637
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/657	27/9376	1.05710581205254	ELOVL2/FADS1	0.0815670203866323
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/657	12/9376	1.18924403855911	GGCX	0.180059944600805
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/657	73/9376	0.977460853610225	PPIA/SAMHD1/BST2/SERINC3/MAP1S	-0.0530667350104106
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/657	28/9376	1.01935203305066	ELOVL2/ACAA2	0.0281501844617719
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/657	28/9376	1.01935203305066	AKR1B1/MOCOS	0.0281501844617719
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	10/657	148/9376	0.964251923156033	WNT2/FOS/JUN/AXIN2/FZD2/GADD45B/HEYL/JAG1/PIK3R1/FZD7	-0.120327455149879
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/657	59/9376	0.967520573743002	ENPP1/NME2/NME4/UPP1	-0.0686959748875856
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	6/657	90/9376	0.951395230847286	EIF4EBP1/CREB3L1/ADCY3/SESN1/ADIPOR1/PIK3R1	-0.127180574955356
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/657	90/9376	0.951395230847286	FOS/JUN/EML4/IFNGR2/PIK3R1/CSNK2B	-0.127180574955356
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/657	75/9376	0.951395230847286	GAPDH/GLUL/IDH1/TALDO1/MAT2B	-0.116005793334823
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	17/657	254/9376	0.955140881362433	HGF/PDGFRA/ITPR2/FGFR2/SLC25A6/GNAS/ADCY3/CALM2/PTGFR/MCOLN2/SLC8A1/EDNRB/TNNC1/CALM3/CALM1/PTAFR/SLC25A5	-0.198956230991053
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	8/657	122/9376	0.935798587718642	SLC16A10/ACTB/ACTG1/GATA4/BMP4/DIO3/MED30/PIK3R1	-0.195927200690528
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/657	62/9376	0.920705062110276	ADCY3/EIF4EBP2/PIK3R1/SOD1	-0.171952373698431
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/657	93/9376	0.920705062110276	FOS/JUN/MAF/RBPJ/IFNGR2/JAG1	-0.210949133824868
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/657	93/9376	0.920705062110276	LAMA2/LAMC3/GADD45B/PTGS2/BCL2L1/PIK3R1	-0.210949133824868
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	12/657	184/9376	0.930712725828866	MYL12A/NRP1/CFL1/GNAI1/MYL12B/EPHA3/CFL2/GNAI2/SLIT2/PLXNA2/DPYSL2/PIK3R1	-0.260550771768896
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/657	31/9376	0.920705062110276	ACSS1/GLUL	-0.121386849970963
NA	NA	hsa04981	Folate transport and metabolism	2/657	31/9376	0.920705062110276	FOLR2/SLCO2B1	-0.121386849970963
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	7/657	110/9376	0.9081499930815	PDE3B/GNAI1/ADCY3/GNAI2/ANAPC11/PIK3R1/HSP90AB1	-0.265989425927856
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/657	48/9376	0.89193302891933	ACAA2/AACS/ALDH6A1	-0.206041315146797
NA	NA	hsa03272	Virion - Hepatitis viruses	3/657	48/9376	0.89193302891933	CD63/DPP4/CD81	-0.206041315146797
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/657	32/9376	0.89193302891933	ACSS1/ALDH6A1	-0.168087933364157
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/657	32/9376	0.89193302891933	GABARAP/GABARAPL2	-0.168087933364157
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/657	32/9376	0.89193302891933	TNFRSF1A/BCL2L1	-0.168087933364157
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	9/657	142/9376	0.904495465946363	RPS27A/UBA52/UBB/ELOB/SOCS1/ANAPC11/WWP1/NEDD4/RBX1	-0.314780783001282
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/657	49/9376	0.873730314043426	ST6GAL2/GXYLT2/GALNT1	-0.243254641726746
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	8/657	128/9376	0.89193302891933	ENPP1/PDE3B/NME2/PAPSS2/ADCY3/GUCY1A1/NME4/PDE3A	-0.337916219342598
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	13/657	205/9376	0.904985707391321	IL6ST/CCND2/HLA-C/JUN/HLA-B/RBPJ/CREB3L1/HLA-A/HNRNPK/YWHAB/PIK3R1/HLA-E/RANBP1	-0.377565676875283
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/657	16/9376	0.89193302891933	MIF	-0.118754487642052
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/657	66/9376	0.864904755315714	HSD17B2/HSD17B11/HSD17B1/COMT	-0.302323685799951
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/657	66/9376	0.864904755315714	JUN/MAF/IL18R1/IFNGR2	-0.302323685799951
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/657	98/9376	0.873730314043426	ITPR2/CALM2/CALM3/PIK3R1/IP6K3/CALM1	-0.344921239614297
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/657	34/9376	0.83946638015937	BHLHE41/RBX1	-0.257407092911526
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/657	83/9376	0.859694485705379	PRDX1/PRDX5/PXMP2/SOD1/IDH1	-0.352428321742205
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	19/657	298/9376	0.909891412051934	CXCL14/BMP5/PRLR/IL6ST/CCL3/INHBB/CSF1R/IL18R1/BMP4/CCL4/CCR1/IFNGR2/CCL4L2/IL1R1/CCL2/TNFRSF1A/CXCL8/CCL3L1/CSH1	-0.433924539343768
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/657	17/9376	0.83946638015937	GGT5	-0.18184891736118
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/657	69/9376	0.82730020073677	FCER1G/PLA2G4A/ALOX5AP/PIK3R1	-0.395226908537995
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/657	36/9376	0.792829359039405	AKR1B1/DCXR	-0.341854267799857
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/657	36/9376	0.792829359039405	GALNT1/ST3GAL1	-0.341854267799857
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/657	36/9376	0.792829359039405	POLD4/SSBP1	-0.341854267799857
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/657	18/9376	0.792829359039405	PRDX1	-0.24149487910239
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/657	87/9376	0.820168302454557	FOS/JUN/AXIN2/GADD45B/PIK3R1	-0.462568838759128
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/657	37/9376	0.771401538524826	MIF/COMT	-0.38243617127118
Human Diseases	Infectious disease: viral	hsa05162	Measles	8/657	136/9376	0.83946638015937	RACK1/CCND2/FOS/JUN/BCL2L1/TLR7/PIK3R1/CSNK2B	-0.51764789385839
NA	NA	hsa04082	Neuroactive ligand signaling	12/657	199/9376	0.860558500263876	OGFRL1/GNAI1/GABRE/GNG5/GNAS/ADCY3/GNGT1/GNG10/GNAI2/GNB2/GNG2/TAC3	-0.545761884406987
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	10/657	168/9376	0.849460027542219	PRLR/IL6ST/CCND2/PDGFRA/SOCS1/IFNGR2/BCL2L1/PIK3R1/CISH/CSH1	-0.540454082702525
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/657	19/9376	0.751101498037331	HEXA	-0.298102592268921
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/657	38/9376	0.751101498037331	PGM3/HEXA	-0.422009405528383
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/657	38/9376	0.751101498037331	ENPP1/NADK2	-0.422009405528383
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/657	73/9376	0.78196868288818	HPGDS/GSTP1/GSTM3/GSTO1	-0.513338434786182
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/657	73/9376	0.78196868288818	HGF/PDGFRA/GADD45B/PIK3R1	-0.513338434786182
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/657	73/9376	0.78196868288818	HGF/GADD45B/EML4/PIK3R1	-0.513338434786182
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/657	20/9376	0.713546423135464	NPL	-0.352013342433891
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/657	39/9376	0.731842485267143	AHCYL1/MAT2B	-0.460631443371629
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/657	57/9376	0.751101498037331	ELOVL2/FADS1/ACAA2	-0.51738047935486
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/657	91/9376	0.78411694850051	FOS/JUN/CD81/LILRB5/PIK3R1	-0.568045697101553
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/657	21/9376	0.679568022033775	CHST14	-0.403513980446166
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/657	21/9376	0.679568022033775	ENPP1	-0.403513980446166
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/657	109/9376	0.785555695195006	IL6ST/FOS/JUN/IFNGR2/IL1R1/HSP90AB1	-0.618148996255069
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/657	76/9376	0.751101498037331	CD36/PLTP/PLIN2/DBI	-0.598029473929955
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/657	59/9376	0.725640430307252	AXIN2/GADD45B/PIK3R1	-0.580287285885205
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/657	41/9376	0.696142851839477	POLD4/SSBP1	-0.535228472913743
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/657	22/9376	0.648678566486786	HNMT	-0.452847826808325
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/657	160/9376	0.802739726027397	CADM3/HLA-C/HLA-B/HLA-A/PTPRD/SDC1/VCAN/CADM1/HLA-E	-0.690817569505586
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/657	60/9376	0.713546423135464	PLA2G4A/PTGS2/PIK3R1	-0.611012533592232
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/657	42/9376	0.679568022033775	INMT/HAAO	-0.571296524052519
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/657	23/9376	0.620475150552578	GLUL	-0.500222994414058
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/657	23/9376	0.620475150552578	FUT4	-0.500222994414058
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/657	79/9376	0.722578656339711	HPGDS/GSTP1/GSTM3/GSTO1	-0.679699554347683
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/657	44/9376	0.648678566486786	POLD4/HMGB1	-0.641177986702439
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/657	63/9376	0.679568022033775	PRDM6/AASS/SMYD3	-0.700480916332453
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/657	63/9376	0.679568022033775	POLD4/POLR2L/RBX1	-0.700480916332453
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/657	133/9376	0.751101498037331	CCND2/GABARAP/CCNG2/GADD45B/GABARAPL2/KLF2/PIK3R1	-0.79355422978891
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/657	45/9376	0.634263487231524	ABCA8/ABCC9	-0.675064804471475
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	8/657	150/9376	0.761116184677828	HGF/WNT2/AXIN2/FGFR2/FZD2/GADD45B/PIK3R1/FZD7	-0.809581574343096
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/657	65/9376	0.658658236740429	PLPP3/AKR1B1/AGPAT2	-0.758023948618783
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/657	65/9376	0.658658236740429	SPP1/ITPR2/PIK3R1	-0.758023948618783
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/657	26/9376	0.548881863950357	SLC19A3	-0.632275188664697
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/657	102/9376	0.699555316799475	ITPR2/PLA2G5/PLA2G2A/GNAS/ADCY3	-0.837463807312997
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/657	47/9376	0.60727355160465	SOCS1/PIK3R1	-0.740894748774206
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/657	120/9376	0.713546423135464	IRAK3/JUN/CALM2/CALM3/PIK3R1/CALM1	-0.866898364747424
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/657	85/9376	0.671573104127496	ENPP1/NME2/NME4/UPP1	-0.834933588394119
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/657	27/9376	0.52855290602627	AACS	-0.673390909667726
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/657	86/9376	0.663764114544618	EIF4EBP1/NRG2/JUN/PIK3R1	-0.859845485313067
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/657	86/9376	0.663764114544618	CREB3L1/GNAS/ADCY3/VAMP2	-0.859845485313067
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/657	104/9376	0.686102329937946	PLPP3/PLA2G5/PLA2G2A/PLA2G4A/AGPAT2	-0.883594562107811
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/657	122/9376	0.701848940788981	CD36/EIF4EBP1/CREB3L1/EEF2/ADIPOR1/PIK3R1	-0.909885006238286
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/657	28/9376	0.509676016525332	FUT4	-0.713243437767368
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	8/657	158/9376	0.722578656339711	CDKN1C/CCND2/RAD21/GADD45B/YWHAB/ANAPC11/SMC3/RBX1	-0.965350546077325
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/657	70/9376	0.611611219830398	CD36/ADIPOR1/TNFRSF1A	-0.895301177160888
NA	NA	hsa04519	Cadherin signaling	23/657	404/9376	0.812453848124538	ACTB/PCDH10/WNT2/CDH11/ACTG1/PDGFRA/GJA1/ARPC3/AXIN2/ARPC5/FZD2/GABRE/ANKRD6/VIM/ARPC1B/YWHAB/KRT8/KRT18/APH1A/PCDH12/PPP1CA/CYFIP2/FZD7	-1.05776499790763
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/657	29/9376	0.492100981472734	RASSF4	-0.751926230757959
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/657	30/9376	0.475697615423643	IDH1	-0.789522581708839
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/657	30/9376	0.475697615423643	FOLR2	-0.789522581708839
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	5/657	109/9376	0.654629745995839	CD36/CREB3L1/TNFRSF1A/PIK3R1/PPP1CA	-0.995551157412036
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/657	31/9376	0.460352531055138	TALDO1	-0.826107039028392
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/657	31/9376	0.460352531055138	ALDH6A1	-0.826107039028392
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/657	32/9376	0.445966514459665	AKR1B1	-0.861746587951454
Human Diseases	Immune disease	hsa05310	Asthma	1/657	32/9376	0.445966514459665	FCER1G	-0.861746587951454
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/657	33/9376	0.432452377657857	IDH1	-0.896501639785598
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/657	56/9376	0.509676016525332	CCND2/SCUBE2	-1.01019258901865
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	20/657	370/9376	0.771401538524826	PRLR/NR3C1/SPX/OGFRL1/TSPO/GABRE/LYPD6/PTGER2/LPAR1/PTGFR/S1PR5/VIPR2/EDNRB/LPAR6/TAC3/PGRMC2/C3AR1/CSH1/PTAFR/S1PR2	-1.23152484565071
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/657	77/9376	0.556010199845816	GADD45B/BCL2L1/PIK3R1	-1.07382921655147
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/657	77/9376	0.556010199845816	GADD45B/BCL2L1/PIK3R1	-1.07382921655147
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/657	34/9376	0.419733190079685	POLR2L	-0.930426865119687
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	5/657	116/9376	0.615126226840917	ACSS1/GAPDH/IDH1/TALDO1/ALDH6A1	-1.14492437902268
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/657	35/9376	0.407740813220265	AKR1B1	-0.96357189951372
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	7/657	154/9376	0.648678566486786	NME2/HAAO/GGCX/NADK2/NME4/DHRS3/MAT2B	-1.20666698887485
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/657	36/9376	0.396414679519702	ENPP1	-0.995981944308319
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/657	37/9376	0.385700769262413	GLUL	-1.02769828065369
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/657	37/9376	0.385700769262413	PGM3	-1.02769828065369
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/657	103/9376	0.554210814085797	SAP18/PELO/PPP1CA/PABPC1	-1.24874279554516
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/657	38/9376	0.375550749018665	PIK3R1	-1.05875871132724
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/657	41/9376	0.348071425919739	GABRE	-1.14833808342556
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	4/657	108/9376	0.52855290602627	EEF1A1/SAP18/SUMO2/TPR	-1.3526542842649
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/657	67/9376	0.425997864558486	ACSS1/GAPDH	-1.29429829311786
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/657	43/9376	0.331882057272309	ACAA2	-1.20534595334649
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	14/657	300/9376	0.6659766615931	HGF/CD14/IGF2/PDGFRA/FOS/JUN/FGFR2/PLA2G4A/CSF1R/GADD45B/ARTN/IL1R1/NRTN/TNFRSF1A	-1.61408046071463
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/657	47/9376	0.303636775802325	ACSS1	-1.31371813168069
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/657	48/9376	0.297311009639777	PIK3R1	-1.33975221351321
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/657	50/9376	0.285418569254186	LAP3	-1.39066974735073
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	6/657	163/9376	0.525310250161078	FOS/JUN/CREB3L1/YWHAB/CXCL8/PIK3R1	-1.67817831403808
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/657	78/9376	0.365921242633571	IP6K3/ALDH6A1	-1.54358560013365
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/657	78/9376	0.365921242633571	LSM3/PABPC1	-1.54358560013365
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/657	156/9376	0.457401553291964	CD81/EIF3E/YWHAB/TNFRSF1A/PIK3R1	-1.87590296128535
NA	NA	hsa04382	Cornified envelope formation	8/657	217/9376	0.526117178348729	S100A9/S100A10/S100A6/S100A11/PCSK6/KRT8/KRT18/PPL	-1.93870525407474
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/657	90/9376	0.317131743615762	GNAS/ADCY3	-1.78681184952935
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/657	117/9376	0.365921242633571	ACTB/ACTG1/SMARCD2	-1.89447586490866
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	13/657	323/9376	0.574371733793253	MARCKS/CCND2/PDGFRA/ZEB2/IGF2BP1/FSCN1/SOCS1/VIM/PTGS2/HNRNPK/PIK3R1/CCNG1/HMGA2	-2.13683233602684
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/657	122/9376	0.350924470394491	FOS/JUN/PIK3R1	-1.98082171455992
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/657	68/9376	0.209866595039842	DHRS3	-1.79498852396463
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/657	72/9376	0.198207339759851	CXCL8	-1.87468566200571
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	5/657	183/9376	0.389916078216101	SBDS/RPP25/NOP10/SNU13/CSNK2B	-2.28781803192597
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/657	83/9376	0.171938897141076	CSNK2B	-2.07997658714799
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/657	86/9376	0.165941028636154	SCN9A	-2.13291285087186
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/657	449/9376	0.158919025197208	ADCY3/CALM2/SLC8A1/CALM3/CALM1	-5.01352513551657