category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	101/1153	222/9376	3.69961635529719	RPS23/RPL27A/RPS18/RPS12/RPS11/RPS14/RPLP1/RPL23A/RPL14/RPL32/RPL26/RPS4X/RPL19/RPL15/RPL23/RPS24/RPS7/RPS27A/RPL10A/RPL7A/RPLP2/RPL13A/RPL30/UBA52/RPL27/RPS15/RPL24/RPL29/RPL21/RPL18/RPL7/RPL13/RPL11/RPL37/RPL41/RPS15A/RPS6/RPS2/RPL28/RPL5/RPL22/RPL38/FAU/RPS20/RPL37A/RPS10/RPS19/RPL35/RPL17/RPL8/RPL34/RPS25/RPL36A/RPS13/RPL6/RPL9/RPL36/RPS8/RPS3A/MRPL14/RPL18A/RPL3/RPL35A/MRPS21/RPL31/RPL10/RPL39/RPS16/RACK1/RPLP0/RPS5/MRPL51/MRPL52/RPL22L1/MRPS34/MRPL34/MRPL20/RPL36AL/MRPL33/RPS17/RPS28/MRPS26/RPL12/MRPL16/MRPS28/MRPL41/MRPL54/MRPL36/MRPS23/RPL26L1/MRPL19/MRPL28/MRPS31/MRPL21/MRPS27/MRPL13/MRPL46/MRPL17/MRPL40/MRPS16/MRPS18C	15.24257113511
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	71/1153	138/9376	4.18376761315786	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-ND1/MT-CO1/COX6C/MT-ND3/MT-ND5/MT-ND4/ATP5MG/MT-ND2/UQCRB/NDUFA4/ATP5F1E/UQCR10/NDUFC2/UQCR11/COX7C/NDUFA13/COX8A/ATP5MF/COX5B/ATP5MC3/COX4I1/NDUFB7/COX6B1/NDUFS6/ATP5MC2/UQCRQ/MT-ND6/NDUFB3/COX6A1/ATP6V0B/NDUFB2/NDUFB9/ATP6V0A1/NDUFC1/NDUFB8/NDUFB4/NDUFA1/ATP5F1D/NDUFB10/NDUFAB1/PPA2/COX7A2/COX7B/NDUFS2/ATP5PF/NDUFV2/UQCRH/NDUFA2/ATP5F1C/NDUFB5/ATP6V1G1/NDUFA5/NDUFS5/NDUFS4/NDUFB11/NDUFS3/ATP5ME/NDUFA11/COX4I2/ATP5F1A/NDUFB6/NDUFA7/NDUFA3/ATP5PO/ATP5PB/UQCRFS1/NDUFA9	14.1083774967453
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	84/1153	205/9376	3.33206693038309	CD36/MT-CO2/MT-ATP6/MT-CYB/COL3A1/MT-CO3/MT-ND1/MT-CO1/COL1A1/TBC1D4/CYBB/COX6C/MT-ND3/MT-ND5/MT-ND4/COL1A2/RYR2/CYBA/MT-ND2/UQCRB/NDUFA4/ATP5F1E/NCF4/UQCR10/NDUFC2/UQCR11/COX7C/NDUFA13/PRKCA/COX8A/COX5B/ATP5MC3/SLC25A4/COX4I1/NDUFB7/COX6B1/NDUFS6/PRKCB/ATP5MC2/UQCRQ/MT-ND6/NDUFB3/COX6A1/SLC25A6/NDUFB2/NDUFB9/PIK3CD/NDUFC1/NDUFB8/NDUFB4/NDUFA1/ATP5F1D/NDUFB10/NDUFAB1/COX7A2/COX7B/NDUFS2/ATP5PF/NDUFV2/UQCRH/NDUFA2/ATP5F1C/PDHB/NDUFB5/SLC25A5/NDUFA5/NDUFS5/NDUFS4/NDUFB11/NDUFS3/NDUFA11/COX4I2/PPP1CA/ATP5F1A/NDUFB6/PLCB1/NDUFA7/NDUFA3/PPP1CC/PARP1/ATP5PO/ATP5PB/UQCRFS1/NDUFA9	12.6413874117745
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	91/1153	238/9376	3.10922912096322	F13A1/RPS23/CCL2/NRP1/RPL27A/RPS18/RPS12/RPS11/RPS14/RPLP1/CYBB/RPL23A/RPL14/RPL32/RPL26/RPS4X/RPL19/RPL15/RPL23/RPS24/RPS7/RPS27A/RPL10A/RPL7A/RPLP2/RPL13A/RPL30/UBA52/RPL27/RPS15/RPL24/RPL29/RPL21/RPL18/RPL7/TNFRSF1A/RPL13/RPL11/RPL37/RPL41/RPS15A/PRKCA/RPS6/EGFR/RPS2/RPL28/RPL5/RPL22/RPL38/FAU/RPS20/RPL37A/RPS10/RPS19/RPL35/RPL17/RPL8/RPL34/RPS25/RPL36A/RPS13/RPL6/RPL9/RPL36/RPS8/SYK/RPS3A/PRKCB/RPL18A/RPL3/RPL35A/RPL31/RPL10/RPL39/RPS16/RPLP0/PIK3CD/RPS5/RPL22L1/RPL36AL/RPS17/RPS28/MMP1/TLR7/RPL12/C3AR1/MAPK3/TLR8/RPL26L1/TLR4/MAP3K7	12.3416096800749
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	88/1153	227/9376	3.15242749234901	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-ND1/MT-CO1/PLD1/HGF/COX6C/MT-ND3/MT-ND5/MT-ND4/CYBA/MT-ND2/UQCRB/NDUFA4/ATP5F1E/MGST2/UQCR10/NDUFC2/UQCR11/COX7C/NDUFA13/EGFR/COX8A/COX5B/ATP5MC3/SLC25A4/COX4I1/NDUFB7/COX6B1/NDUFS6/CAT/ATP5MC2/ABL1/UQCRQ/PTPRJ/MT-ND6/NDUFB3/COX6A1/MAP2K2/AKR1A1/SLC25A6/NDUFB2/NDUFB9/PIK3CD/HIF1A/NDUFC1/NDUFB8/NDUFB4/NDUFA1/ATP5F1D/MGST3/NDUFB10/NDUFAB1/COX7A2/COX7B/NDUFS2/ATP5PF/NDUFV2/UQCRH/NDUFA2/SOS1/ATP5F1C/NDUFB5/GSTA4/SLC25A5/MAP3K5/NDUFA5/MAPK3/NDUFS5/BAD/NDUFS4/NDUFB11/NDUFS3/NDUFA11/COX4I2/ATP5F1A/NDUFB6/ARNT/NDUFA7/NDUFA3/ATP5PO/MAP2K7/ATP5PB/ACP1/UQCRFS1/NDUFA9	12.292487972998
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	104/1153	308/9376	2.74581273020128	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-ND1/MT-CO1/COX6C/MT-ND3/MT-ND5/CLTC/MT-ND4/MT-ND2/CLTA/GRIA4/UQCRB/NDUFA4/ATP5F1E/TUBA1B/UQCR10/NDUFC2/UQCR11/AP2S1/COX7C/NDUFA13/DCTN4/COX8A/COX5B/ATP5MC3/SLC25A4/COX4I1/NDUFB7/COX6B1/NDUFS6/ATP5MC2/UQCRQ/MT-ND6/NDUFB3/COX6A1/SLC25A6/NDUFB2/NDUFB9/NDUFC1/SEM1/NDUFB8/NDUFB4/POLR2J/NDUFA1/ATP5F1D/CREB1/BDNF/NDUFB10/AP2M1/NDUFAB1/COX7A2/COX7B/NDUFS2/ATP5PF/NDUFV2/UQCRH/NDUFA2/ATP5F1C/POLR2K/TUBB/PSMA7/NDUFB5/SLC25A5/MAP3K5/NDUFA5/BAX/PSMB1/NDUFS5/PSMA1/NDUFS4/NDUFB11/NDUFS3/ULK2/PSMA2/NDUFA11/POLR2G/COX4I2/HTT/AMBRA1/ATP5F1A/POLR2E/PSMB5/PIK3C3/NDUFB6/PLCB1/POLR2I/ATG14/POLR2L/ACTR10/TUBA1A/NDUFA7/NDUFA3/DCTN6/ATP5PO/MAP2K7/ATP5PB/DNAH8/DCTN3/PSMC2/UQCRFS1/NDUFA9	11.6654744072546
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	95/1153	275/9376	2.80917763935977	MT-CO2/MT-ATP6/ITPR2/MT-CYB/MT-CO3/MT-ND1/MT-CO1/CYBB/COX6C/MT-ND3/MT-ND5/GRIN2C/MT-ND4/RYR2/CYBA/MT-ND2/UQCRB/NDUFA4/ATP5F1E/TUBA1B/NCF4/UQCR10/NDUFC2/UQCR11/COX7C/NDUFA13/PPP3CA/COX8A/COX5B/ATP5MC3/RYR1/SLC25A4/COX4I1/NDUFB7/COX6B1/NDUFS6/ATP5MC2/PPP3R1/UQCRQ/MT-ND6/NDUFB3/COX6A1/SLC25A6/NDUFB2/NDUFB9/PIK3CD/NDUFC1/SEM1/NDUFB8/NDUFB4/NDUFA1/CCL5/ATP5F1D/CREB1/NDUFB10/LAMC1/NDUFAB1/COX7A2/COX7B/NDUFS2/ATP5PF/NDUFV2/UQCRH/ATF6B/NDUFA2/ATP5F1C/TUBB/PSMA7/NDUFB5/SLC25A5/NDUFA5/BAX/MAPK3/PSMB1/NDUFS5/PSMA1/BAD/NDUFS4/NDUFB11/NDUFS3/PSMA2/NDUFA11/COX4I2/ATP5F1A/PSMB5/NDUFB6/NCAM2/TUBA1A/NDUFA7/NDUFA3/ATP5PO/ATP5PB/PSMC2/UQCRFS1/NDUFA9	11.4021866994862
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	91/1153	268/9376	2.7611810850345	MT-CO2/MT-ATP6/ITPR2/MT-CYB/MT-CO3/MT-ND1/MT-CO1/COX6C/MT-ND3/MT-ND5/MT-ND4/MT-ND2/RPS27A/UQCRB/NDUFA4/UBA52/PRKN/ATP5F1E/TUBA1B/UQCR10/NDUFC2/UQCR11/COX7C/NDUFA13/COX8A/CALML4/COX5B/CALM2/ATP5MC3/SLC25A4/COX4I1/NDUFB7/COX6B1/NDUFS6/ATP5MC2/UQCRQ/MT-ND6/NDUFB3/COX6A1/SLC25A6/NDUFB2/NDUFB9/NDUFC1/SEM1/NDUFB8/NDUFB4/GNAI2/NDUFA1/ATP5F1D/NDUFB10/NDUFAB1/COX7A2/COX7B/NDUFS2/ATP5PF/NDUFV2/UQCRH/NDUFA2/ATP5F1C/SNCA/TUBB/PSMA7/NDUFB5/SLC25A5/CALM3/SLC39A12/MAP3K5/TXN2/NDUFA5/BAX/PSMB1/NDUFS5/PSMA1/NDUFS4/NDUFB11/NDUFS3/PSMA2/NDUFA11/COX4I2/ATP5F1A/PSMB5/PARK7/NDUFB6/TUBA1A/NDUFA7/NDUFA3/ATP5PO/ATP5PB/PSMC2/UQCRFS1/NDUFA9	10.9533015776494
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	83/1153	235/9376	2.87209315199941	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-ND1/MT-CO1/COX6C/MT-ND3/MT-ND5/MT-ND4/ATP5MG/MT-ND2/UQCRB/NDUFA4/PRKG1/ATP5F1E/UQCR10/ACTB/NDUFC2/UQCR11/COX7C/NDUFA13/RPS6/COX8A/ATP5MF/COX5B/ATP5MC3/COX4I1/NDUFB7/COX6B1/NDUFS6/ARID1B/ATP5MC2/UQCRQ/MT-ND6/NDUFB3/COX6A1/NDUFB2/NDUFB9/NDUFAF8/NDUFC1/NDUFB8/NDUFB4/NDUFA1/ATP5F1D/CREB1/NDUFB10/COA1/NDUFAB1/COX7A2/COX7B/NDUFS2/ATP5PF/NDUFV2/UQCRH/NDUFA2/SOS1/ATP5F1C/NDUFB5/MAP3K5/NDUFA5/NDUFS5/NDUFS4/NDUFB11/NDUFS3/COX16/ATP5ME/NDUFA11/COX4I2/COA5/SMARCA2/ATP5F1A/ARID1A/NDUFB6/SMARCB1/NDUFAF3/NDUFA7/NDUFA3/ATP5PO/ATP5PB/UQCRFS1/NDUFA9/COX14	10.88302628357
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	130/1153	480/9376	2.20237062734894	MT-CO2/MT-ATP6/ITPR2/MT-CYB/MT-CO3/MT-ND1/MT-CO1/WNT2/CYBB/COX6C/MT-ND3/MT-ND5/GRIN2C/MT-ND4/RYR2/MT-ND2/RPS27A/GRIA4/UQCRB/NDUFA4/UBA52/PRKN/ATP5F1E/TUBA1B/UQCR10/NDUFC2/UQCR11/TNFRSF1A/COX7C/NDUFA13/DCTN4/PRKCA/PPP3CA/COX8A/CALML4/COX5B/CALM2/ATP5MC3/RYR1/SLC25A4/COX4I1/FIG4/NDUFB7/COX6B1/NDUFS6/PRKCB/CAT/ATP5MC2/PPP3R1/UQCRQ/MT-ND6/NDUFB3/COX6A1/MAP2K2/SLC25A6/NDUFB2/NDUFB9/NDUFC1/APC/SEM1/NDUFB8/NDUFB4/NDUFA1/ATP5F1D/BDNF/NDUFB10/NDUFAB1/ATXN2/COX7A2/COX7B/NDUFS2/ATP5PF/NDUFV2/UQCRH/NDUFA2/ATP5F1C/SNCA/TUBB/PSMA7/NDUFB5/SLC25A5/CALM3/MAP3K5/NDUFA5/BAX/MAPK3/PSMB1/NDUFS5/PSMA1/BAD/NDUFS4/NDUFB11/NDUFS3/ULK2/PSMA2/SPG11/NDUFA11/COX4I2/FZD2/HTT/AMBRA1/FZD5/ATP5F1A/PSMB5/PARK7/CDK5/LRP6/PIK3C3/WDR41/NDUFB6/PLCB1/ATG14/ACTR10/TUBA1A/NDUFA7/FZD3/NDUFA3/CAPN1/DCTN6/ATP5PO/MAP2K7/ATP5PB/DNAH8/DKK2/DCTN3/MAP1LC3A/PSMC2/VCP/UQCRFS1/NDUFA9	10.1262054994553
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	112/1153	388/9376	2.34733237363757	MT-CO2/MT-ATP6/ITPR2/MT-CYB/MT-CO3/MT-ND1/MT-CO1/WNT2/CYBB/COX6C/MT-ND3/MT-ND5/GRIN2C/MT-ND4/MT-ND2/UQCRB/NDUFA4/ATP5F1E/TUBA1B/UQCR10/NDUFC2/UQCR11/ADAM10/TNFRSF1A/COX7C/NDUFA13/PPP3CA/COX8A/CALML4/COX5B/CALM2/ATP5MC3/SLC25A4/COX4I1/NDUFB7/COX6B1/NDUFS6/ATP5MC2/PPP3R1/APH1B/UQCRQ/MT-ND6/NDUFB3/COX6A1/MAP2K2/SLC25A6/NDUFB2/NDUFB9/PIK3CD/NDUFC1/APC/SEM1/NDUFB8/NDUFB4/NDUFA1/ATP5F1D/NDUFB10/NDUFAB1/COX7A2/COX7B/NDUFS2/ATP5PF/NDUFV2/UQCRH/NDUFA2/ATP5F1C/SNCA/TUBB/PSMA7/NDUFB5/SLC25A5/CALM3/SLC39A12/MAP3K5/NDUFA5/MAPK3/PSENEN/PSMB1/NDUFS5/PSMA1/BAD/NDUFS4/NDUFB11/NDUFS3/ULK2/PSMA2/NDUFA11/COX4I2/FZD2/AMBRA1/FZD5/ATP5F1A/PSMB5/CDK5/LRP6/PIK3C3/NDUFB6/PLCB1/ATG14/TUBA1A/NDUFA7/FZD3/BACE1/NDUFA3/CAPN1/ATP5PO/MAP2K7/ATP5PB/DKK2/PSMC2/UQCRFS1/NDUFA9	10.1494900642234
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	105/1153	368/9376	2.32022323617029	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-ND1/MT-CO1/COX6C/MT-ND3/MT-ND5/GRIN2C/MT-ND4/MT-ND2/UQCRB/NDUFA4/PRKN/ATP5F1E/TUBA1B/UQCR10/ACTB/NDUFC2/UQCR11/TNFRSF1A/COX7C/NDUFA13/DCTN4/PPP3CA/COX8A/COX5B/ATP5MC3/COX4I1/FIG4/NDUFB7/COX6B1/NDUFS6/CAT/ATP5MC2/PPP3R1/PFN1/UQCRQ/MT-ND6/NDUFB3/COX6A1/NUP160/NDUFB2/NDUFB9/NDUFC1/SEM1/NDUFB8/NDUFB4/NDUFA1/ATP5F1D/NDUFB10/NDUFAB1/ATXN2/COX7A2/COX7B/NDUFS2/POM121/ATP5PF/NDUFV2/UQCRH/CHCHD10/NDUFA2/ATP5F1C/TUBB/PSMA7/NDUFB5/MAP3K5/NDUFA5/BAX/PSMB1/NDUFS5/PSMA1/BAD/NDUFS4/NDUFB11/NDUFS3/ULK2/NUP107/PSMA2/SPG11/NDUFA11/COX4I2/AMBRA1/ATP5F1A/PSMB5/PIK3C3/WDR41/NDUFB6/NUP214/ATG14/ACTR10/TUBA1A/NDUFA7/NDUFA3/DCTN6/ATP5PO/ATP5PB/DNAH8/DCTN3/MAP1LC3A/PSMC2/VCP/UQCRFS1/NDUFA9	9.67480542471781
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	54/1153	157/9376	2.79693516221875	MT-CO2/MT-CYB/MT-CO3/MT-CO1/COX6C/UQCRB/NDUFA4/UQCR10/NDUFC2/UQCR11/TNFRSF1A/COX7C/NDUFA13/COX8A/COX5B/COX4I1/NDUFB7/COX6B1/NDUFS6/UQCRQ/NDUFB3/COX6A1/NDUFB2/NDUFB9/PIK3CD/NDUFC1/NDUFB8/NDUFB4/NDUFA1/NDUFB10/NDUFAB1/COX7A2/COX7B/NDUFS2/NDUFV2/UQCRH/NDUFA2/NDUFB5/MLXIP/MAP3K5/NDUFA5/BAX/NDUFS5/MAP3K11/NDUFS4/NDUFB11/NDUFS3/NDUFA11/COX4I2/NDUFB6/NDUFA7/NDUFA3/UQCRFS1/NDUFA9	8.50208558523849
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	50/1153	149/9376	2.72880201633323	ITPR2/GNG2/MT-ND1/GNG10/MT-ND3/MT-ND5/MT-ND4/MT-ND2/GRIA4/GNGT1/GABRA3/NDUFA4/NDUFC2/GNG12/NDUFA13/GNG11/PRKCA/NDUFB7/NDUFS6/PRKCB/MT-ND6/KCNJ5/NDUFB3/NDUFB2/NDUFB9/NDUFC1/NDUFB8/NDUFB4/GNAI2/NDUFA1/GNB2/NDUFB10/NDUFAB1/NDUFS2/NDUFV2/NDUFA2/GNG5/NDUFB5/NDUFA5/MAPK3/NDUFS5/NDUFS4/NDUFB11/NDUFS3/NDUFA11/NDUFB6/PLCB1/NDUFA7/NDUFA3/NDUFA9	7.96513756804218
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	25/1153	87/9376	2.33673276111294	MT-CO2/MT-CYB/MT-CO3/MT-CO1/COX6C/ATP1B1/RYR2/UQCRB/CACNB4/UQCR10/UQCR11/CACNA2D3/COX7C/COX8A/COX5B/COX4I1/COX6B1/UQCRQ/COX6A1/ASPH/COX7A2/COX7B/UQCRH/COX4I2/UQCRFS1	4.69034602637029
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	25/1153	97/9376	2.09583247646212	GNG2/GNG10/GRIN2C/RYR2/GRIA4/GNGT1/PRKG1/GNG12/GNG11/PRKCA/CALML4/CALM2/RYR1/PRKCB/KCNJ5/GNAI2/CREB1/GNB2/GNG5/CALM3/MAPK3/PER3/GUCY1A2/PLCB1/GUCY1A1	4.06223079065027
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	25/1153	98/9376	2.07444643078394	PLD1/SCIN/PLPP3/ASAP2/ARPC3/LYN/PRKCA/ARPC1B/INPP5D/BIN1/WASF2/SYK/PRKCB/VAV3/FCGR1A/LIMK2/PIK3CD/FCGR3A/PTPRC/VAV1/CFL1/MAPK3/HCK/WAS/ARPC1A	4.00364689934771
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	50/1153	250/9376	1.62636600173461	DAB2/WWP1/EPS15/SNX2/SNX6/PLD1/FOLR2/CLTC/CLTA/DNM1/AP2S1/ASAP2/SNX3/ARPC3/GRK3/EGFR/CYTH4/ARPC1B/ARAP2/BIN1/ACAP2/CAPZA2/VPS28/CAPZB/EPN2/AP2M1/WIPF1/GIT2/VPS36/WASHC3/VPS45/CAPZA1/MVB12A/VPS29/EPS15L1/VPS25/CHMP2A/VPS37A/STAM2/RAB5C/EPN1/CHMP4A/RAB11FIP2/SNX4/SNX5/ARRB1/ARF5/ARPC1A/STAM/FGFR3	3.7587470099514
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	49/1153	250/9376	1.59383868169991	CTSC/LGMN/CLTC/CLTA/AP2S1/OSBPL6/SUMF1/CD63/FUCA1/WDR7/FIG4/MCOLN1/LAMTOR5/PLA2G15/LAMTOR2/AP1S2/BLOC1S1/ATP6V0B/SLC38A9/VPS13C/LAMTOR4/ATP6V0A1/LAMTOR1/AP1B1/VAMP8/AP2M1/SLC36A1/NEU1/DTNBP1/HYAL2/CTBS/BORCS7/TLR7/ACP2/ATP6V1G1/VPS29/PIKFYVE/TLR8/NAGLU/MFSD8/SPG11/CD164/NAGA/SLC29A3/LAMTOR3/BLOC1S4/CTNS/AP1S1/ROGDI	3.56355447621944
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	31/1153	142/9376	1.77525866386524	WWP1/RPS27A/UBA52/PRKN/SKP2/PIAS2/UBE2E3/HERC2/PIAS1/ELOB/UBE4B/ANAPC11/BTRC/HERC3/RBX1/COP1/UBE2W/BIRC6/MAP3K1/CUL5/UBE2M/UBE2F/UBE2I/TRIM32/ANAPC1/FBXO4/CUL2/CDC16/ANAPC10/CDC27/UBE3C	3.48562781180523
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	32/1153	154/9376	1.6897309108931	ITPR2/MEF2C/RYR2/CACNB4/MAP2K5/ACTB/CACNA2D3/PRKCA/EGFR/PPP3CA/CALML4/CALM2/RYR1/NFATC2/PRKCB/PPP3R1/KCNJ5/MAP2K2/ROCK2/MYL6/GNAI2/TRPM2/PPP1R12A/CALM3/MAPK3/CCND1/GUCY1A2/PPP1CA/PLCB1/GUCY1A1/PPP1CC/NFATC3	3.23156308112342
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	36/1153	184/9376	1.5910102190882	NRP1/UNC5C/SLIT2/EPHA3/SEMA3D/ABLIM3/PRKCA/PPP3CA/NFATC2/NCK2/SRGAP1/MYL12A/PPP3R1/ABL1/LRRC4/EPHB3/ROCK2/ENAH/LIMK2/PIK3CD/ROBO2/GNAI2/EFNA5/SLIT3/ROBO1/MYL12B/FES/CFL1/MAPK3/EPHA7/EFNA4/LRIG2/SRGAP3/CDK5/FZD3/NFATC3	3.03168476050304
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	10/1153	31/9376	2.62317097053969	SPCS1/SRP14/SEC11A/SEC61B/SPCS2/SEC11C/SRP9/IMMP1L/SEC61G/GET1	3.38953878543472
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	13/1153	48/9376	2.20237062734894	HIBCH/HMGCLL1/HIBADH/AUH/PCCA/BCKDHB/MCCC1/ALDH9A1/ACADS/HMGCL/HADHB/ALDH7A1/DLD	3.12715821943712
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	37/1153	196/9376	1.53509035878011	ITPR2/GNG2/GNG10/RPS27A/GNGT1/UBA52/GNG12/TNFRSF1A/CD200R1/RB1/LYN/GNG11/PPP3CA/CALML4/CALM2/NFATC2/CD86/SYK/PPP3R1/MAP2K2/PIK3CD/HIF1A/CREB1/GNB2/GNG5/CCR1/CALM3/BAX/MAPK3/CCND1/PIK3C3/CDK6/ATG14/HCK/NFATC3/MAP2K7/MAP1LC3A	2.83477743930914
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	39/1153	212/9376	1.49594986008608	MAGI1/HGF/PDGFC/CSF1R/IGF1/ACTB/PRKCA/EGFR/CALML4/CALM2/FYB1/PRKCB/VAV3/MAGI3/PFN1/FGF7/MAP2K2/ANGPT1/ENAH/AFDN/PIK3CD/LPAR5/GNAI2/EFNA5/KITLG/EVL/SIPA1L2/SIPA1/VAV1/CALM3/MAPK3/SIPA1L3/FGF10/EFNA4/VEGFB/PLCB1/TLN2/ID1/FGFR3	2.7349431859992
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	32/1153	166/9376	1.5675816884189	ITPR2/MEF2C/ATP1B1/PRKG1/PPP3CA/CALML4/CALM2/SLC25A4/NFATC2/PPP3R1/MAP2K2/SLC25A6/ROCK2/GTF2I/GNAI2/CREB1/PDE3A/ATF6B/PPP1R12A/SLC25A5/CALM3/GATA4/MAPK3/BAD/GUCY1A2/ATP2B4/PPP1CA/PLCB1/ADRB1/GUCY1A1/PPP1CC/NFATC3	2.76272559535603
NA	NA	hsa04517	IgSF CAM signaling	51/1153	299/9376	1.38703454997433	MAGI1/NRP1/UNC5C/MTSS1/SLIT2/CD28/PMP22/PTPRD/CADM3/ANK2/CABLES1/TUBA1B/ACTB/KIRREL1/ARPC3/LYN/PRKCA/ARPC1B/INPP5D/CD86/NCK2/LMO7/SRGAP1/JAM3/PRKCB/VAV3/MYL12A/MTSS2/ABL1/MAP2K2/AFDN/PIK3CD/MYL6/ROBO2/IL1RAPL1/SLIT3/TUBB/ROBO1/NRCAM/VAV1/MYL12B/MAPK3/DOK1/CADM2/SRGAP3/MYH10/NCAM2/MPDZ/SLITRK4/TUBA1A/ARPC1A	2.54682619861272
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	37/1153	204/9376	1.47489073686717	ITPR2/LUM/COL1A1/DCN/WNT2/HGF/GPC3/COL1A2/ANK2/IGF1/ACTB/ITGB5/TWIST1/PRKCA/RPS6/EGFR/CD63/PDCD4/PRKCB/VAV3/MAP2K2/ROCK2/PIK3CD/HIF1A/SOS1/PPP1R12A/VAV1/VTN/MAPK3/CCND1/GAB1/FZD2/FZD5/PPP1CA/TLR4/FZD3/PPP1CC	2.56780420547122
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/1153	47/9376	2.07621191710801	AKR1A1/ACSS1/LDHB/ACYP2/PDHB/HAGH/MDH1/ADH5/ALDH9A1/GRHPR/ALDH7A1/DLD	2.76958262451456
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	33/1153	178/9376	1.50758646228208	ROR1/WNT2/TLE4/PRICKLE1/RSPO2/PRKCA/PPP3CA/SERPINF1/CCND2/NFATC2/INVS/NLK/PRKCB/PPP3R1/RSPO3/ROCK2/APC/BTRC/RBX1/CCND1/FRZB/FZD2/FZD5/ANKRD6/LRP6/LZTS2/PLCB1/CTBP1/FZD3/MAP3K7/NFATC3/DKK2/CBY1	2.5601091149638
Organismal Systems	Immune system	hsa04611	Platelet activation	25/1153	126/9376	1.61345833505417	ITPR2/COL3A1/COL1A1/COL1A2/PRKG1/ACTB/LYN/SYK/FCER1G/MYL12A/ROCK2/TBXAS1/PIK3CD/VAMP8/GNAI2/PPP1R12A/MYL12B/MAPK3/GUCY1A2/PPP1CA/PLCB1/GUCY1A1/TLN2/PPP1CC/ARHGAP35	2.59588007221583
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	41/1153	232/9376	1.43709064808446	TMSB4X/SCIN/PDGFC/ACTB/ITGB5/GNG12/ARPC3/EGFR/ARPC1B/WASF2/ITGA9/VAV3/MYL12A/CYFIP1/PFN1/NCKAP1L/FGF7/MAP2K2/ROCK2/ENAH/LIMK2/PIK3CD/APC/LPAR5/DIAPH2/SOS1/PPP1R12A/VAV1/MYL12B/CFL1/MAPK3/FGD3/FGF10/PIKFYVE/BRK1/PPP1CA/MYH10/PPP1CC/ARPC1A/ARHGAP35/FGFR3	2.52425104643244
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	19/1153	89/9376	1.73600865353694	ITPR2/PDGFC/PRKG1/TUBA1B/MAP2K5/PRKCA/EGFR/GJA1/PRKCB/MAP2K2/GNAI2/SOS1/TUBB/MAPK3/GUCY1A2/PLCB1/ADRB1/GUCY1A1/TUBA1A	2.61231381886992
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	38/1153	214/9376	1.44396981462418	ITPR2/GNG2/GNG10/GNGT1/ATM/GNG12/TNFRSF1A/GNG11/PRKCA/PPP3CA/CALML4/CALM2/NFATC2/PRKCB/PPP3R1/ELOB/MAP2K2/AP1S2/LIMK2/PIK3CD/AP1B1/GNAI2/BTRC/GNB2/RBX1/GNG5/ATR/CALM3/CFL1/BAX/MAPK3/BAD/CUL5/TLR4/MAP3K7/NFATC3/MAP2K7/AP1S1	2.46008624780815
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	9/1153	32/9376	2.28707718993929	HIBCH/SUCLG2/ACSS1/LDHB/PCCA/BCKDHB/ACSS3/ACADS/DLD	2.73085294753169
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	16/1153	73/9376	1.78231890601053	HGF/RB1/PRKCA/EGFR/RARB/PRKCB/MAP2K2/PIK3CD/JAK3/SOS1/BAX/MAPK3/CDKN2A/CCND1/BAD/CDK6	2.51257417763931
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	36/1153	203/9376	1.44209793257256	LAMA2/SPP1/COL1A1/HGF/COL1A2/PDGFC/IGF1/ACTB/ITGB5/PRKCA/EGFR/ARHGAP5/CCND2/COL6A1/ITGA9/PRKCB/VAV3/MYL12A/ROCK2/PIK3CD/LAMC1/SOS1/PPP1R12A/LAMC3/VAV1/MYL12B/VTN/COL6A2/MAPK3/CCND1/BAD/PPP1CA/VEGFB/TLN2/PPP1CC/ARHGAP35	2.38449245673629
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	20/1153	98/9376	1.65955714462715	ITPR2/INPP4B/PRKCA/CALML4/INPP5D/CALM2/PRKCB/CDS1/PIP4P2/PPIP5K2/PIK3CD/DGKZ/SYNJ1/CALM3/DGKH/PIKFYVE/SACM1L/PIK3C3/PLCB1/INPP4A	2.45766921586073
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	31/1153	170/9376	1.48286311922861	WNT2/HGF/MGST2/ACTB/RB1/PRKCA/EGFR/ARID1B/PRKCB/MAP2K2/PIK3CD/APC/MGST3/PBRM1/SOS1/GSTA4/BAX/MAPK3/CDKN2A/CCND1/GAB1/BAD/FZD2/SMARCA2/FZD5/ARID1A/LRP6/BRD7/CDK6/SMARCB1/FZD3	2.37902035373527
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	41/1153	238/9376	1.40086147208233	GNG2/GNG10/PLD1/HGF/PDGFC/CSF1R/GNGT1/IGF1/RALGAPA2/GNG12/GNG11/PRKCA/EGFR/CALML4/RGL1/CALM2/PRKCB/ABL1/FGF7/MAP2K2/ANGPT1/AFDN/PIK3CD/RGL2/GNB2/BDNF/RASA2/SOS1/EFNA5/KITLG/GNG5/CALM3/MAPK3/GAB1/BAD/FGF10/EFNA4/RAB5C/VEGFB/EXOC2/FGFR3	2.34553741698818
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	11/1153	44/9376	2.03295750216826	MAN1A1/MAN1C1/TMEM258/MGAT4B/FUT8/KRTCAP2/DAD1/OSTC/TUSC3/MAN1A2/ST3GAL3	2.57161869369106
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	29/1153	157/9376	1.50205777230266	ITPR2/ATM/RB1/PPP3CA/CALML4/CALM2/CCND2/SLC25A4/NFATC2/PPP3R1/MAP2K2/SLC25A6/PIK3CD/BTRC/SLC25A5/ATR/CALM3/GATA4/MAPK3/CDKN2A/CCND1/MRE11/LIN52/PPP1CA/RBL2/CDK6/PPP1CC/CAPN1/NFATC3	2.37545474015928
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	13/1153	56/9376	1.88774625201338	MAN1A1/ST6GAL1/MAN1C1/MGAT5/TMEM258/MGAT4B/FUT8/KRTCAP2/DAD1/OSTC/TUSC3/MAN1A2/DPM2	2.49493968742374
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	19/1153	93/9376	1.66134161467513	PTPRM/ACTB/EGFR/WASF2/FER/NLK/LMO7/MYL12A/PTPRJ/ROCK2/AFDN/CCM2/MYL12B/PTPRB/MAPK3/WAS/MAP3K7/CDH5/ACP1	2.39998372780926
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	42/1153	248/9376	1.37716475953334	CD14/TUBA1B/ACTB/LY96/TNFRSF1A/EXOC4/ARPC3/DCTN4/CYTH4/ARPC1B/DYNC2H1/ELMO1/MYL12A/CYFIP1/PFN1/NCKAP1L/MAP2K2/ROCK2/PIK3CD/PYCARD/SNX18/DYNLRB1/TUBB/PTPRC/NAIP/MYL12B/TXN2/BAX/MAPK3/BRK1/RAB5C/PIK3C3/TLR4/ACTR10/TUBA1A/PKN1/EXOC2/DCTN6/MAP3K7/MAP2K7/ARPC1A/DCTN3	2.2540019062068
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	14/1153	63/9376	1.80707333526067	POLE/POLR2J/RFC4/RBX1/GTF2H5/RPA3/POLR2K/MNAT1/XPA/POLR2G/POLR2E/POLR2I/POLR2L/RFC1	2.40670920452621
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	25/1153	133/9376	1.52853947531448	ITPR2/GNG2/GNG10/GRIA4/GNGT1/GNG12/GNG11/PRKCA/PPP3CA/CALML4/CALM2/PRKCB/KCNJ5/GNAI2/CREB1/GNB2/ATF6B/GNG5/SCN1A/CALM3/PPP1CA/PLCB1/PPP2R5E/PPP1CC/ARRB1	2.29869801038053
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	58/1153	362/9376	1.30288989089236	MAGI1/GNG2/LAMA2/SPP1/COL1A1/GNG10/HGF/COL1A2/PDGFC/CSF1R/GNGT1/CSH1/IGF1/PKN2/ITGB5/GNG12/GNG11/PRKCA/RPS6/EGFR/EPOR/CCND2/COL6A1/ITGA9/SYK/FGF7/MAP2K2/ANGPT1/PIK3CD/LPAR6/LPAR5/CREB1/GNB2/BDNF/LAMC1/JAK3/ATF6B/SOS1/EFNA5/KITLG/GNG5/LAMC3/VTN/COL6A2/MAPK3/CCND1/BAD/FGF10/EFNA4/SGK3/VEGFB/RBL2/CDK6/PPP2R5E/TLR4/YWHAB/PKN1/FGFR3	2.20072326123704
Human Diseases	Cancer: specific types	hsa05214	Glioma	16/1153	76/9376	1.71196421235222	IGF1/RB1/PRKCA/EGFR/CALML4/CALM2/PRKCB/MAP2K2/PIK3CD/SOS1/CALM3/BAX/MAPK3/CDKN2A/CCND1/CDK6	2.33350444497048
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	17/1153	83/9376	1.66555554394508	CAT/FAR1/HMGCLL1/PXMP2/SCP2/NUDT12/ABCD4/GSTK1/HMGCL/AGPS/PEX2/NUDT19/IDH2/PEX11G/ECH1/AMACR/PEX14	2.28050237939454
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	22/1153	116/9376	1.54224362233454	CYBB/CYBA/NCF4/ACTB/PRKCA/ARHGAP5/CD99/TXK/JAM3/PRKCB/VAV3/MYL12A/ROCK2/AFDN/PIK3CD/GNAI2/SIPA1/VAV1/MYL12B/CLDN5/CDH5/ARHGAP35	2.20040741965694
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	24/1153	130/9376	1.5012609246781	GNG2/COL3A1/COL1A1/GNG10/COL1A2/GNGT1/GNG12/GNG11/PRKCA/EGFR/MAP2K2/PIK3CD/GNAI2/CREB1/GNB2/ATF6B/SOS1/GNG5/MMP1/MAPK3/VEGFB/PLCB1/ARRB1/MAP2K7	2.15498240823905
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	26/1153	144/9376	1.4682470848993	ITPR2/RBPJ/GRIN2C/PRKCA/RYR1/SLC25A4/PRKCB/SLC25A6/PIK3CD/SEM1/ATXN2/ATXN10/PUM2/PSMA7/SLC25A5/MAP3K5/PSMB1/PSMA1/ULK2/PSMA2/AMBRA1/PSMB5/PIK3C3/PLCB1/ATG14/PSMC2	2.12028175951223
Organismal Systems	Nervous system	hsa04730	Long-term depression	13/1153	60/9376	1.76189650187916	ITPR2/PRKG1/IGF1/LYN/PRKCA/RYR1/PRKCB/MAP2K2/GNAI2/MAPK3/GUCY1A2/PLCB1/GUCY1A1	2.21687911298432
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	25/1153	138/9376	1.47315761026685	CCL2/PKN2/ACTB/ARPC3/ARPC1B/NFATC2/WASF2/FYB1/ELMO1/VAV3/MAP2K2/ROCK2/PIK3CD/PYCARD/WIPF1/GIT2/VAV1/MAPK3/TLR4/PKN1/WAS/MAP3K7/NFATC3/MAP2K7/ARPC1A	2.09672532427122
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	33/1153	193/9376	1.39041652998036	CXCL14/CCL2/GNG2/GNG10/CCL4L2/GNGT1/GNG12/LYN/GNG11/GRK3/ELMO1/PRKCB/VAV3/CCL13/DOCK2/ROCK2/PIK3CD/GNAI2/CCL5/GNB2/JAK3/SOS1/GNG5/CCR1/VAV1/MAPK3/BAD/PLCB1/HCK/WAS/ARRB1/CCL8/PPBP	2.0521056031603
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	8/1153	31/9376	2.09853677643175	SHMT1/CAT/ACSS1/GCSH/PCCA/MDH1/GRHPR/DLD	2.29398694193244
NA	NA	hsa04981	Folate transport and metabolism	8/1153	31/9376	2.09853677643175	FOLR2/ABCG2/SLCO2B1/SHMT1/ABCC5/ABCC4/SLC46A1/MTR	2.29398694193244
Human Diseases	Cancer: specific types	hsa05218	Melanoma	15/1153	73/9376	1.67092397438487	HGF/PDGFC/IGF1/RB1/EGFR/FGF7/MAP2K2/PIK3CD/BAX/MAPK3/CDKN2A/CCND1/BAD/FGF10/CDK6	2.15480699782025
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	14/1153	67/9376	1.69918836002123	ITPR2/GRIN2C/PRKCA/PPP3CA/CALML4/CALM2/PRKCB/PPP3R1/MAP2K2/CALM3/MAPK3/PPP1CA/PLCB1/PPP1CC	2.150627637291
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	16/1153	80/9376	1.62636600173461	HGF/PDGFC/GAS6/IGF1/PRKCA/RPS6/EGFR/PRKCB/MAP2K2/PIK3CD/SOS1/BAX/MAPK3/GAB1/BAD/FGFR3	2.10673669331068
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1153	21/9376	2.32338000247801	ENPP1/VNN2/VNN1/PPCDC/CSAD/AASDHPPT	2.27330373734956
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	27/1153	155/9376	1.41651232409143	CD36/CD14/CYBB/CYBA/TUBA1B/NCF4/COLEC12/ACTB/ITGB5/MRC1/DYNC2H1/STX7/FCAR/CORO1A/ATP6V0B/FCGR1A/ATP6V0A1/FCGR3A/TUBB/SEC61B/ATP6V1G1/PIKFYVE/RAB5C/PIK3C3/TLR4/TUBA1A/SEC61G	1.95789700014637
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	37/1153	227/9376	1.32545246837402	ITPR2/CCL2/GNG2/GNG10/CCL4L2/GNGT1/GNG12/TNFRSF1A/RB1/GNG11/PRKCA/EGFR/PPP3CA/CALML4/CALM2/NFATC2/PRKCB/PPP3R1/MAP2K2/ROCK2/PIK3CD/GNAI2/CCL5/CREB1/GNB2/ATF6B/SOS1/GNG5/CCR1/CALM3/BAX/MAPK3/CDKN2A/CCND1/CDK6/PLCB1/NFATC3	1.85865520092578
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	47/1153	300/9376	1.27398670135877	MEF2C/CD14/MKNK1/HGF/MAP3K8/PDGFC/CSF1R/CACNB4/IGF1/MAP2K5/GNG12/CACNA2D3/TNFRSF1A/PRKCA/EGFR/PPP3CA/STK3/NLK/PRKCB/PPP3R1/FGF7/MAP2K2/ANGPT1/BDNF/RASA2/DUSP9/SOS1/EFNA5/MAP3K1/KITLG/MAP3K3/MAP3K5/MAPK3/MAP3K11/FGF10/MAPKAPK3/EFNA4/DUSP3/VEGFB/STMN1/LAMTOR3/DUSP7/MAP3K7/ARRB1/NFATC3/MAP2K7/FGFR3	1.80604270065304
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	27/1153	158/9376	1.38961652046944	CDC14B/HDAC8/ATM/SKP2/RB1/CCND2/ATRX/ABL1/ANAPC11/RBX1/PDS5B/ATR/CDKN2A/CCND1/CDKN2C/SMC3/RBL2/CDC14A/CDK6/PPP2R5E/CDKN2D/YWHAB/ANAPC1/CDC16/ANAPC10/ORC4/CDC27	1.84940787168543
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	13/1153	65/9376	1.62636600173461	ITPR2/SPP1/PRKCA/PRKCB/KCNJ5/MAP2K2/PIK3CD/KISS1/MAPK3/CGA/GPER1/PLCB1/ARRB1	1.89745654463303
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	12/1153	59/9376	1.65393152718773	ENPP1/NME3/NME2/NME4/DUT/HDDC2/NT5C/NUDT2/AK9/DTYMK/TK2/NME7	1.88671099678506
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	16/1153	85/9376	1.53069741339728	ENPP1/NME3/NME2/NME4/NUDT16/DUT/HDDC2/AK1/APRT/IMPDH1/NT5C/ITPA/AK9/DTYMK/TK2/NME7	1.84039205793351
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	6/1153	23/9376	2.12134695878427	MSH3/RFC4/RPA3/SSBP1/RFC1/MSH2	2.016107137302
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	8/1153	36/9376	1.80707333526067	POLE/RFC4/RNASEH2B/RPA3/PRIM2/SSBP1/POLA1/RFC1	1.81666963831056
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/1153	30/9376	1.89742700202371	FOLR2/ABCG2/SHMT1/ABCC5/ABCC4/SLC46A1/MTR	1.84345278277582
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	21/1153	122/9376	1.39974123100109	TBC1D4/ATP1B1/ACTB/PRKCA/NCOA2/PRKCB/BMP4/MAP2K2/NCOA1/PIK3CD/HIF1A/GATA4/MAPK3/CCND1/BAD/NCOR1/THRA/MED30/PLCB1/PFKFB2/MED16	1.66409938467969
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	26/1153	157/9376	1.34667248551273	CD36/GAS6/PROS1/VPS8/ITGB5/ADAM10/EPOR/TIMD4/NFATC2/ELMO1/PLA2G15/MAP2K2/ADAM9/HIF1A/ARG2/CREB1/DNMT3A/CH25H/STAB1/MAPK3/RAB5C/ARNT/DUSP7/NFATC3/UQCRFS1/GULP1	1.64025903874977
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	10/1153	49/9376	1.65955714462715	ST6GAL1/GALNT1/GXYLT2/COLGALT1/C1GALT1/GALNT10/C1GALT1C1/ST3GAL3/POMT1/RFNG	1.73326364376859
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	20/1153	116/9376	1.40203965666776	ITPR2/GNG2/GNG10/PLD1/GRIN2C/GRIA4/GNGT1/GNG12/GNG11/GRK3/PRKCA/PPP3CA/PRKCB/PPP3R1/GNAI2/GNB2/SLC1A1/GNG5/MAPK3/PLCB1	1.63146417420155
Organismal Systems	Endocrine system	hsa04924	Renin secretion	13/1153	69/9376	1.53208391467753	ITPR2/PPP3CA/CALML4/CALM2/PPP3R1/GNAI2/CREB1/PDE3A/CALM3/GUCY1A2/PLCB1/ADRB1/GUCY1A1	1.66105864250731
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	13/1153	69/9376	1.53208391467753	GRIN2C/GRIA4/PRKCA/PPP3CA/CALML4/CALM2/PRKCB/PPP3R1/CREB1/ATF6B/CALM3/PPP1CA/PPP1CC	1.66105864250731
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	19/1153	110/9376	1.40458881967989	MKNK1/CYBB/IGF1/PRKCA/RPS6/EGFR/PRKCB/ELOB/MAP2K2/ANGPT1/PIK3CD/LDHB/HIF1A/RBX1/PDHB/MAPK3/ARNT/TLR4/CUL2	1.59826658138757
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	39/1153	253/9376	1.25352320291798	ITPR2/CD14/RPS27A/UBA52/ACTB/ATM/TNFRSF1A/ARPC3/EGFR/CYTH4/ARPC1B/WASF2/ELMO1/MYL12A/SEPTIN7/PFN1/ROCK2/PIK3CD/CCL5/PYCARD/BTRC/RBX1/NAIP/MYL12B/FNBP1L/BAX/MAPK3/TECPR1/PIK3C3/PLCB1/ATG14/TLR4/TLN2/GLMN/CAPN1/MAP3K7/ARPC1A/MAP1LC3A/RBCK1	1.53071480538893
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	35/1153	224/9376	1.27059843885516	NRP1/ATM/DLG1/TNFRSF1A/RB1/PPP3CA/CCND2/SLC25A4/NFATC2/PPP3R1/MAP2K2/SLC25A6/TSPO/PIK3CD/ANAPC11/CREB1/JAK3/ATF6B/MAP3K1/MAP3K3/SLC25A5/ATR/BAX/MAPK3/CDKN2A/CCND1/CDKN2C/TRRAP/RANBP1/TLN2/ANAPC1/NFATC3/CDC16/ANAPC10/CDC27	1.53488710288705
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	12/1153	63/9376	1.54892000165201	PRDM6/SMYD3/TMLHE/NSD1/CAMKMT/COLGALT1/ALDH9A1/EZH1/PHYKPL/EHMT1/ALDH7A1/DLD	1.63689067995008
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/1153	50/9376	1.62636600173461	CD36/CR1/CCL2/HBB/HBA2/HBA1/HGF/GYPC/GYPB/TLR4	1.66284060154269
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	8/1153	38/9376	1.71196421235222	ENPP1/NMRK1/NUDT12/QPRT/NT5C/NADK2/SIRT3/NNT	1.64667606957307
Human Diseases	Substance dependence	hsa05032	Morphine addiction	16/1153	91/9376	1.42977230921724	GNG2/PDE4D/GNG10/GNGT1/GABRA3/GNG12/GNG11/GRK3/PRKCA/PRKCB/KCNJ5/GNAI2/GNB2/PDE3A/GNG5/ARRB1	1.54259997058428
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	23/1153	140/9376	1.33594350142485	ITPR2/MEF2C/GNG2/SPP1/GNG10/RYR2/GNGT1/GNG12/GNG11/RPS6/CALML4/CALM2/RYR1/MAP2K2/GNAI2/GNB2/GNG5/CALM3/MAPK3/CCND1/PIK3C3/PLCB1/MAP1LC3A	1.49959314620955
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	23/1153	142/9376	1.31712739577098	MEF2C/CCL2/CYBA/MGST2/MAP2K5/ACTB/TNFRSF1A/CALML4/CALM2/BMPR1A/BMP4/SUMO2/PIK3CD/MGST3/GSTA4/CALM3/MAP3K5/TXN2/SUMO1/MAP3K7/MAP2K7/CDH5/ACVR2A	1.42583130264359
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	16/1153	93/9376	1.39902451762117	ITPR2/PLD1/PRKCA/EGFR/CALML4/CALM2/PRKCB/MAP2K2/SOS1/MAP3K1/MAP3K3/CALM3/MAPK3/CGA/PLCB1/MAP2K7	1.44804489546323
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	33/1153	216/9376	1.24236291799171	CD36/CCL2/CD14/CYBB/CYBA/NCF4/LY96/TNFRSF1A/LYN/PRKCA/PPP3CA/CALML4/CALM2/NFATC2/POU2F2/VAV3/PPP3R1/ROCK2/PIK3CD/CCL5/PYCARD/MMP1/VAV1/CALM3/MAP3K5/BAX/MAPK3/BAD/PLCB1/TLR4/MAP3K7/NFATC3/MAP2K7	1.34936815965495
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/1153	53/9376	1.53430754880623	ATP1B1/CLTC/CLTA/DNM1/AP2S1/PRKCA/PRKCB/AP2M1/ATP2B4/PLCB1	1.46061766720014
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	25/1153	158/9376	1.28668196339763	WNT2/IGF1/SKP2/TNFRSF1A/PRKCA/RPS6/PRKCB/RICTOR/LAMTOR5/MAP2K2/LAMTOR2/PRR5/SLC38A9/LAMTOR4/PIK3CD/LAMTOR1/SOS1/ATP6V1G1/MAPK3/ULK2/FZD2/FZD5/LRP6/LAMTOR3/FZD3	1.36080441131961
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/1153	34/9376	1.67420029590327	POLR2J/POLR2K/POLR2G/POLR1A/POLR2E/POLR2I/POLR2L	1.47466581431936
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	7/1153	34/9376	1.67420029590327	BHLHE41/CREB1/BTRC/RBX1/NR1D2/PER3/DBP	1.47466581431936
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/1153	41/9376	1.58669853827766	RB1/EGFR/MAP2K2/MMP1/MAPK3/CDKN2A/CCND1/FGFR3	1.40972668327102
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	19/1153	117/9376	1.32055359115203	ACTB/BAZ2B/SMARCA1/ARID1B/PBRM1/MTA3/EPC1/BPTF/SMARCA2/CDK2AP1/ARID1A/TRRAP/BRD7/MEAF6/BRD8/SMARCB1/MTA1/ACTR6/RBBP7	1.30646169887801
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	18/1153	110/9376	1.33066309232831	BMP5/DCN/PITX2/BMPR1A/BMP4/RBX1/HFE/NRROS/MAPK3/NCOR1/THSD4/SMAD5/SMAD6/ID1/FST/TMEM53/GDF6/ACVR2A	1.30623424192681
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	17/1153	103/9376	1.3421467004606	COL3A1/COL1A1/COL14A1/COL15A1/ATP1B1/COL1A2/COL6A1/COL5A2/KCNQ1/COL21A1/SLC1A1/SLC36A1/COL5A1/DPP4/COL6A2/PRCP/PGA5	1.3073924882373
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	13/1153	75/9376	1.40951720150332	MGST2/ATM/PIK3CD/MSH3/MGST3/XPA/GSTA4/MAP3K5/BAX/MAPK3/CDKN2A/BAD/MSH2	1.33328534327087
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	13/1153	75/9376	1.40951720150332	IGF1/ATM/CCND2/ZMAT3/CCNG2/SESN3/COP1/MDM4/ATR/BAX/CDKN2A/CCND1/CDK6	1.33328534327087
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	17/1153	104/9376	1.3292414437254	PLD1/SGMS1/PLPP3/CEPT1/CDS1/PLA2G15/DGKZ/AGPAT2/MBOAT1/ETNK1/DGKH/PTDSS2/LCLAT1/LPCAT2/LYPLA1/PLB1/GPD1L	1.26424021890008
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	12/1153	69/9376	1.41423130585618	LYN/PRKCA/INPP5D/SYK/VAV3/FCER1G/MAP2K2/PIK3CD/SOS1/VAV1/MAPK3/MAP2K7	1.29314657257869
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	13/1153	76/9376	1.39097092253618	ITPR2/ATP1B1/ACTB/PRKCA/CALML4/CALM2/HRH2/PRKCB/KCNQ1/GNAI2/CFTR/CALM3/PLCB1	1.28143011932885
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	10/1153	56/9376	1.45211250154875	DISP1/GRK3/CCND2/SUFU/BTRC/CCND1/GLI3/GLI2/CDON/ARRB1	1.27062594827763
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/1153	70/9376	1.3940280014868	HGF/ELOB/MAP2K2/PIK3CD/HIF1A/RBX1/SOS1/MAPK3/GAB1/BAD/ARNT/CUL2	1.23902402790932
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	16/1153	99/9376	1.31423515291685	PLD1/PDGFC/PLPP3/PRKCA/EGFR/WASF2/PRKCB/MAP2K2/PIK3CD/HIF1A/DGKZ/SOS1/DGKH/MAPK3/LYPLA1/WAS	1.17693840015679
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	20/1153	128/9376	1.27059843885516	PDE4D/ENPP1/PDE9A/NUDT5/NME3/NME2/NME4/NUDT16/PDE3A/HDDC2/AK1/APRT/GUCY1A2/IMPDH1/NT5C/ITPA/NUDT2/AK9/GUCY1A1/NME7	1.15422774016587
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	19/1153	122/9376	1.26643254233432	CD28/MAP3K8/DLG1/PPP3CA/NFATC2/NCK2/VAV3/PPP3R1/MAP2K2/PIK3CD/TEC1/SOS1/PTPRC/VAV1/MAPK3/PPP2R5E/MAP3K7/NFATC3/MAP2K7	1.10914310401966
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	9/1153	51/9376	1.43502882505995	ENPP2/PLD1/PLPP3/CEPT1/PLA2G7/TMEM86A/LPCAT2/AGPS/PLB1	1.16644387999911
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/1153	51/9376	1.43502882505995	ACTB/PRKCA/KCNQ1/ATP6V0B/ATP6V0A1/CFTR/SEC61B/ATP6V1G1/SEC61G	1.16644387999911
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	26/1153	174/9376	1.21510103577873	MAN1A1/MAN1C1/PRKN/UBE4B/UGGT2/EDEM3/TMEM258/RBX1/ATF6B/WFS1/SEC61B/MBTPS1/MAP3K5/BAX/KRTCAP2/TRAM1/DAD1/OSTC/TUSC3/MAN1A2/DNAJC10/DNAJC5/CAPN1/MAP2K7/SEC61G/VCP	1.07241074824079
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	17/1153	108/9376	1.28001027914298	SUMO2/NUP160/PNN/POM121/NUP42/XPO7/UPF2/SAP18/NUP107/SRRM1/SUMO1/XPO4/PHAX/NUP214/UPF3A/UBE2I/IPO11	1.09591781411473
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	21/1153	138/9376	1.23745239262416	ITPR2/IGF1/PPP3CA/CALML4/CALM2/CPEB4/PPP3R1/ANAPC11/BTRC/RBX1/CALM3/MAPK3/SMC3/PPP1CA/PPP2R5E/YWHAB/PPP1CC/ANAPC1/CDC16/ANAPC10/CDC27	1.05223383101261
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1153	38/9376	1.49796868580819	ATP1B1/NR3C2/IGF1/PRKCA/PRKCB/PIK3CD/MAPK3	1.15173361819405
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	10/1153	59/9376	1.37827627265645	HPGDS/MGST2/GPX4/LAP3/MGST3/GSTA4/GSTK1/LANCL1/IDH2/SRM	1.09139561830437
NA	NA	hsa04518	Integrin signaling	23/1153	154/9376	1.21449409220441	LAMA2/SPP1/COL1A1/HGF/COL1A2/PDGFC/IGF1/ACTB/ITGB5/EGFR/CCND2/COL6A1/ITGA9/NCK2/FREM1/PIK3CD/LAMC1/LAMC3/VTN/COL6A2/CCND1/VEGFB/TLN2	1.00495885937508
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/1153	32/9376	1.52471812662619	ATG7/ATG4C/GABARAPL2/ATG10/ULK2/PIK3C3	1.11331942941824
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/1153	60/9376	1.3553050014455	PRKCA/PPP3CA/NFATC2/PRKCB/PPP3R1/MAP2K2/PIK3CD/MAPK3/BAD/MAPKAPK3	1.03382576833032
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	8/1153	46/9376	1.41423130585618	SEM1/PSMA7/PSMB1/PSMA1/POMP/PSMA2/PSMB5/PSMC2	1.05454752957531
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/1153	19/9376	1.71196421235222	GCSH/PDHB/BCKDHB/DLD	1.16319304389038
Cellular Processes	Cell motility	hsa04814	Motor proteins	28/1153	194/9376	1.17366618681879	TUBA1B/ACTB/DCTN4/DYNC2H1/TNNT3/MYO7A/MYL12A/CAPZA2/CAPZB/MYL6/KIF16B/DYNLRB1/TUBB/CAPZA1/KIF26B/MYL12B/TNNT1/MYH10/MYO1B/KIFAP3/ACTR10/MYO1F/TUBA1A/KIF20B/DCTN6/DNAH8/DCTN3/TUBG2	0.915235034171228
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	22/1153	149/9376	1.20067288718662	PLD1/PDGFC/PLPP3/DNM1/PRKCA/EGFR/CYTH4/SYK/FCER1G/MAP2K2/PIK3CD/LPAR6/LPAR5/DGKZ/SOS1/KITLG/AGPAT2/DGKH/MAPK3/GAB1/PTGFR/PLCB1	0.924563447703404
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	11/1153	68/9376	1.31544308963828	CD14/CSF1R/RUNX1T1/MAP2K2/FCGR1A/PIK3CD/SOS1/MAPK3/CCND1/BAD/PIM1	0.977535264731829
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	18/1153	120/9376	1.21977450130095	MAP2K5/CALML4/CALM2/ABL1/MAP2K2/PIK3CD/BDNF/KIDINS220/SOS1/MAP3K1/MAP3K3/CALM3/MAP3K5/BAX/MAPK3/GAB1/BAD/MAP2K7	0.907280130753298
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	14/1153	91/9376	1.25105077056508	LYN/PPP3CA/INPP5D/NFATC2/SYK/PRKCB/VAV3/PPP3R1/MAP2K2/PIK3CD/SOS1/VAV1/MAPK3/NFATC3	0.90110717462046
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	12/1153	77/9376	1.26729818316982	RB1/ABL1/MAP2K2/PIK3CD/SOS1/BAX/MAPK3/CDKN2A/CCND1/BAD/CDK6/CTBP1	0.881877764065554
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/1153	41/9376	1.38836122099296	SHMT1/GAMT/GCSH/ALAS2/GRHPR/ALDH7A1/DLD	0.933159263680285
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	7/1153	41/9376	1.38836122099296	RAD51B/ATM/BABAM2/SEM1/RPA3/SSBP1/MRE11	0.933159263680285
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/1153	63/9376	1.29076666804334	WNT2/BMP4/APC/SUFU/BAX/GLI3/FZD2/FZD5/GLI2/FZD3	0.867072155373954
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	12/1153	78/9376	1.25105077056508	INPP4B/PLCH1/INPP5D/FIG4/PPIP5K2/PIK3CD/SYNJ1/PIKFYVE/SACM1L/PIK3C3/PLCB1/INPP4A	0.833679717756621
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	12/1153	78/9376	1.25105077056508	PAN3/NUDT16/LSM8/LSM4/CNOT2/LSM3/LSM7/C1D/LSM6/PABPC4L/XRN2/PARN	0.833679717756621
Organismal Systems	Digestive system	hsa04970	Salivary secretion	14/1153	93/9376	1.22414645291852	ITPR2/ATP1B1/PRKG1/PRKCA/CALML4/CALM2/PRKCB/PRH1/CALM3/GUCY1A2/ATP2B4/PLCB1/ADRB1/GUCY1A1	0.813419007232541
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	24/1153	169/9376	1.15481609590623	WDFY3/RPS27A/UBA52/ATG7/STX7/ATG4C/MAP2K2/GABARAPL2/PIK3CD/HIF1A/VAMP8/BIRC6/UVRAG/ATG10/MAPK3/BAD/ULK2/AMBRA1/PIK3C3/WDR41/ATG14/RAB33B/MAP3K7/MAP1LC3A	0.760476045889138
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	15/1153	101/9376	1.20769752604055	WNT2/PRKCA/CALML4/CALM2/PRKCB/MAP2K2/GNAI2/CREB1/KITLG/CALM3/MAPK3/FZD2/FZD5/PLCB1/FZD3	0.785814789070011
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	28/1153	200/9376	1.13845620121422	TUBA1B/ACTB/TNFRSF1A/ARPC3/CYTH4/ARPC1B/WASF2/NCK2/CYFIP1/ABL1/NCKAP1L/ROCK2/LPAR5/PYCARD/WIPF1/TUBB/NAIP/BAX/MAPK3/CLDN5/BRK1/MYH10/MYO1B/TLR4/MYO1F/TUBA1A/MAP3K7/ARPC1A	0.741115427545972
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	35/1153	254/9376	1.12052775710061	ITPR2/HGF/GRIN2C/RYR2/PDGFC/HRH1/PRKCA/EGFR/PPP3CA/CALML4/CALM2/RYR1/SLC25A4/NFATC2/HRH2/PRKCB/MCOLN1/PHKB/PPP3R1/FGF7/SLC25A6/ASPH/SLC25A5/CALM3/FGF10/ATP2B4/VEGFB/PTGFR/PLCB1/CYSLTR1/ADRB1/PTAFR/NFATC3/PHKA1/FGFR3	0.729195610903265
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	24/1153	170/9376	1.14802306004796	MAGI1/TUBA1B/ACTB/DLG1/ARPC3/ARPC1B/JAM3/MYL12A/ROCK2/AFDN/MYL6/MAP3K1/CFTR/MYL12B/GATA4/MAP3K5/CLDN5/CCND1/MYH10/MPDZ/TUBA1A/WAS/MAP2K7/ARPC1A	0.729295443476483
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	28/1153	201/9376	1.13279224001415	MEF2C/CD14/BMP2K/TSPAN7/CSF1R/IGF1/ATM/LYL1/FLI1/MAF/RUNX1T1/NR4A3/CCND2/CD86/ETV1/MLF1/PROM1/ETV5/FCGR1A/LMO2/FUT8/HHEX/TAF15/KLF3/BAX/NCOR1/CDKN2C/MLLT1	0.71261151511862
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	18/1153	125/9376	1.17098352124892	PLD1/SGMS1/TNFRSF1A/PRKCA/PRKCB/FCER1G/ORMDL1/MAP2K2/ROCK2/PIK3CD/GNAI2/DEGS1/MAP3K5/BAX/MAPK3/SGPP1/PLCB1/PPP2R5E	0.720609643071424
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	10/1153	65/9376	1.25105077056508	PLPP3/AKR1A1/DGKZ/AGPAT2/MBOAT1/DGKH/LCLAT1/ALDH9A1/ABHD16A/ALDH7A1	0.760510510348091
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/1153	103/9376	1.1842470886417	COL3A1/LAMA2/COL1A1/CD14/COL1A2/PRKCA/PRKCB/PIK3CD/ARG2/LAMC1/SERPINB6/LAMC3/RAB5C/PLCB1/TLR4	0.704035021660234
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1153	22/9376	1.47851454703146	HNMT/ALDH9A1/ASPA/ALDH7A1	0.841381481998427
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	27/1153	195/9376	1.12594569350857	CR1/HDAC9/CYBB/CYBA/HDAC8/ATG7/NCF4/ACTB/PRKCA/CLCN5/SLC25A4/SYK/PRKCB/MAP2K2/SLC25A6/FCGR1A/PIK3CD/FCGR3A/TLR7/SLC25A5/FPR2/MAPK3/TLR8/PLCB1/TLR4/MAP3K7/HAT1	0.66548884603771
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	13/1153	89/9376	1.18779539452527	CD36/LAMA2/SPP1/COL1A1/COL1A2/ITGB5/COL6A1/ITGA9/FREM1/LAMC1/LAMC3/VTN/COL6A2	0.66654176127004
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/1153	89/9376	1.18779539452527	GNG2/GNG10/GNGT1/GABRA3/GNG12/GNG11/PRKCA/SLC12A5/PRKCB/GABARAPL2/GNAI2/GNB2/GNG5	0.66654176127004
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	9/1153	59/9376	1.2404486453908	EGFR/MAP2K2/PIK3CD/APC/SOS1/BAX/MAPK3/CCND1/BAD	0.693737929064025
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/1153	37/9376	1.31867513654157	HBB/HBA2/HBA1/PRKCA/PRKCB/PLCB1	0.727250454964655
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	12/1153	82/9376	1.19002390370825	MGST2/NME3/NME2/NME4/MGST3/DUT/GSTA4/IMPDH1/ITPA/CES2/TK2/NME7	0.647141087658849
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/1153	30/9376	1.3553050014455	SUCLG2/PDHB/MDH1/IDH2/DLD	0.729850998657135
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	15/1153	105/9376	1.161690001239	EDA/CD14/CCL4L2/ATM/LY96/TNFRSF1A/LYN/SYK/PRKCB/CCL13/TNFRSF11A/TLR4/UBE2I/PARP1/MAP3K7	0.623877998330768
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	13/1153	90/9376	1.17459766791944	CD28/EGFR/PPP3CA/NFATC2/PPP3R1/MAP2K2/PIK3CD/HIF1A/MAP3K3/MAPK3/BATF/TLR4/NFATC3	0.623204384850061
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/1153	23/9376	1.41423130585618	LARGE1/B4GAT1/ST3GAL3/POMT1	0.74476029536478
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	14/1153	99/9376	1.14995575880225	IGF1/RB1/EGFR/MAP2K2/PIK3CD/SOS1/BAX/MAPK3/CDKN2A/CCND1/BAD/NCOR1/CDKN2C/GPER1	0.561645281314888
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1153	31/9376	1.31158548526984	HIBCH/ALDH9A1/ACADS/CSAD/ALDH7A1	0.650659176679016
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	16/1153	115/9376	1.13138504468494	ITPR2/GNG2/GNG10/GNGT1/GNG12/GNG11/PRKCA/PRKCB/KCNQ1/PIK3CD/GNAI2/CREB1/GNB2/GNG5/MAPK3/PLCB1	0.530824620453364
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	16/1153	115/9376	1.13138504468494	ITPR2/MEF2C/PDE4D/PLD1/NACA/PRKCA/EGFR/PRKCB/GNAI2/CREB1/ATF6B/MMP16/MAPK3/LRP6/PLCB1/ARRB1	0.530824620453364
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	21/1153	154/9376	1.10888591027359	ATP1B1/RYR2/CACNB4/CACNA2D3/PRKCA/CALML4/CALM2/CREM/SCN1B/KCNQ1/GNAI2/CREB1/ATF6B/CALM3/MAPK3/ATP2B4/PPP1CA/PLCB1/PPP2R5E/ADRB1/PPP1CC	0.510157921208787
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8/1153	54/9376	1.20471555684045	APIP/ADI1/LDHB/AHCYL2/DNMT3A/MTR/MDH1/SRM	0.56490877950451
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/1153	39/9376	1.25105077056508	SHMT1/AHCYL2/GCSH/MTR/ALDH7A1/DLD	0.588268141985489
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1153	17/9376	1.43502882505995	CH25H/SCP2/AMACR	0.672222304050568
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	30/1153	226/9376	1.07944646132828	PDE4D/PLD1/ATP1B1/GRIN2C/RYR2/GRIA4/CALML4/CALM2/VAV3/MAP2K2/ABCC4/ROCK2/AFDN/PIK3CD/GNAI2/CREB1/BDNF/PDE3A/PPP1R12A/CFTR/VAV1/CALM3/MAPK3/CGA/BAD/GLI3/ATP2B4/PPP1CA/ADRB1/PPP1CC	0.452692580992422
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/1153	70/9376	1.161690001239	LAMA2/CD28/EIF4G3/DTNA/ACTB/CD86/ABL1/SGCE/CCND1/SGCG	0.508435430608661
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	14/1153	101/9376	1.12718435763785	CCL2/COL3A1/COL1A1/CYBB/COL1A2/PRKCA/PRKCB/PIK3CD/BAX/MAPK3/CCND1/PIM1/VEGFB/PLCB1	0.481196627978498
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	15/1153	109/9376	1.11905917550546	SPP1/CD14/CCL4L2/MAP3K8/LY96/CD86/MAP2K2/PIK3CD/CCL5/TLR7/MAPK3/TLR8/TLR4/MAP3K7/MAP2K7	0.46815717617283
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	11/1153	78/9376	1.14679653968466	CLTC/CLTA/ACTB/DNM1/ARPC3/ARPC1B/WASF2/ELMO1/PIK3CD/GAB1/ARPC1A	0.487476288148769
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	11/1153	78/9376	1.14679653968466	C4BPB/CD14/LY96/CALML4/CALM2/GNAI2/PYCARD/CALM3/CFL1/MAPK3/TLR4	0.487476288148769
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/1153	86/9376	1.13467395469856	PRKCA/EGFR/NCK2/PRKCB/ABL1/MAP2K2/PIK3CD/SOS1/MAPK3/GAB1/BAD/MAP2K7	0.469796880511941
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	18/1153	133/9376	1.10054842222642	IGF1/ATM/SKP2/EGFR/CCND2/CCNG2/NLK/CAT/MAP2K2/GABARAPL2/PIK3CD/SOS1/MAPK3/CCND1/SGK3/RBL2/CDKN2D/FBXO25	0.43730027540755
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/1153	71/9376	1.14532817023564	EGFR/MAP2K2/PIK3CD/LDHB/HIF1A/PDHB/MAPK3/IDH2/SIRT3/FGFR3	0.46026286650816
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	21/1153	157/9376	1.08769700752951	BMP5/WNT2/ACTB/DLG1/STK3/CCND2/BMPR1A/BMP4/APC/BTRC/YAP1/CCND1/FZD2/FZD5/GLI2/PPP1CA/YWHAB/FZD3/ID1/PPP1CC/GDF6	0.414932869733927
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	11/1153	79/9376	1.13228012778992	SYT1/CLTC/CLTA/DNM1/AP2S1/ATP6V0B/ATP6V0A1/STX2/SLC1A1/AP2M1/ATP6V1G1	0.442101392356842
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	24/1153	181/9376	1.07825370280747	CR1/CD14/MRC1/TNFRSF1A/PPP3CA/CALML4/CALM2/SYK/FCER1G/PPP3R1/CORO1A/ATP6V0B/FCGR1A/ATP6V0A1/CREB1/FCGR3A/CALM3/BAX/MAPK3/BAD/RAB5C/RFXANK/PIK3C3/TLR4	0.398064514430034
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	18/1153	134/9376	1.09233537429936	ITPR2/PRKG1/PRKCA/CALML4/CALM2/PRKCB/MAP2K2/ROCK2/MYL6/PPP1R12A/CALM3/MAPK3/GUCY1A2/PPP1CA/MYH10/PLCB1/GUCY1A1/PPP1CC	0.403109170147909
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/1153	33/9376	1.23209545585955	STX7/VAMP8/STX2/STX8/STX16	0.500110047457846
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	43/1153	333/9376	1.05005612724607	MAGI1/RBPJ/LAMA2/SPP1/COL1A1/WNT2/COL1A2/ITGB5/ATM/DLG1/TNFRSF1A/RB1/MAML2/EGFR/CCND2/COL6A1/ITGA9/MAP2K2/ATP6V0B/ATP6V0A1/PIK3CD/APC/CREB1/LAMC1/SOS1/LAMC3/ATP6V1G1/VTN/ATR/COL6A2/BAX/MAPK3/CCND1/BAD/FZD2/FZD5/RBL2/CDK6/PPP2R5E/FZD3/UBR4/TUBG2/RFNG	0.348263727517834
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/1153	42/9376	1.161690001239	CAT/INMT/ALDH9A1/HAAO/ALDH7A1/DLD	0.393241241016681
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/1153	42/9376	1.161690001239	CYBB/ATG7/NCOA4/GPX4/SAT2/MAP1LC3A	0.393241241016681
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/1153	50/9376	1.13845620121422	LAP3/GAMT/ARG2/ALDH9A1/SAT2/ALDH7A1/SRM	0.36756559627565
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/1153	27/9376	1.20471555684045	ELOVL2/HSD17B12/SCP2/HACD3	0.398873602802966
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	14/1153	106/9376	1.07401528416436	FOLR2/PDGFC/IGF1/RB1/EGFR/ETV5/MAP2K2/SLC46A1/PIK3CD/CREB1/SOS1/MAPK3/CCND1/BAD	0.286958849941017
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	11/1153	83/9376	1.07771241078799	MBD5/SCML2/SCMH1/ASXL2/KDM2A/PHC3/AUTS2/LCOR/EZH1/MBD6/RBBP7	0.266278809218552
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1153	12/9376	1.3553050014455	COQ7/COQ2	0.461154433326615
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	20/1153	155/9376	1.04926838821587	ITPR2/WNT2/RB1/EGFR/MAP2K2/APC/GNAI2/CREB1/ATF6B/MAPK3/CDKN2A/CCND1/CDKN2C/FZD2/FZD5/ASH2L/CDK6/PLCB1/ARNT/FZD3	0.231595618929952
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	14/1153	107/9376	1.06397775814413	ITPR2/PYGL/PPP3CA/CALML4/CALM2/PHKB/PPP3R1/LDHB/CREB1/PDHB/CALM3/PLCB1/PHKA1/PPP4C	0.249223856661061
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1153	28/9376	1.161690001239	ELOVL2/HSD17B12/HACD3/HADHB	0.320839606407349
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	19/1153	148/9376	1.04395114976208	WNT2/IGF1/RB1/EGFR/FGF7/MAP2K2/NCOA1/PIK3CD/APC/SOS1/BAX/MAPK3/CCND1/FGF10/FZD2/FZD5/LRP6/CDK6/FZD3	0.201805246234032
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	15/1153	116/9376	1.05152974250082	PGLS/HIBCH/SUCLG2/SHMT1/CAT/ACSS1/GCSH/PDHB/PCCA/ESD/MDH1/ADH5/ACADS/IDH2/DLD	0.209106060563063
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/1153	44/9376	1.10888591027359	POLE/RFC4/PARG/MPG/PARP1/RFC1	0.271078957025216
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/1153	77/9376	1.05608181930819	PLD1/RB1/EGFR/PIK3CD/BAX/MAPK3/CDKN2A/CCND1/BAD/CDK6	0.185026732429412
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	19/1153	150/9376	1.03003180109858	WNT2/HGF/RB1/EGFR/RARB/FGF7/MAP2K2/PIK3CD/APC/SOS1/BAX/MAPK3/CCND1/GAB1/FGF10/FZD2/FZD5/LRP6/FZD3	0.138837066883753
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1153	45/9376	1.0842440011564	ABCG2/ABCC5/ABCC4/ABCA9/CFTR/ABCD4	0.212112515451053
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	18/1153	142/9376	1.03079535321207	ITPR2/CYBA/CSF1R/NCF4/TNFRSF1A/PPP3CA/NFATC2/SYK/PPP3R1/FCGR1A/PIK3CD/CREB1/TEC1/FCGR3A/TNFRSF11A/MAPK3/MAP3K7/MAP2K7	0.138458484417569
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/1153	37/9376	1.09889594711798	NCOA4/MAP2K2/BAX/MAPK3/CCND1	0.225691038580057
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/1153	29/9376	1.12163172533421	GNGT1/CALML4/CALM2/CALM3	0.245637626058809
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1153	21/9376	1.161690001239	CHSY3/CSGALNACT1/B3GAT3	0.277751275839451
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1153	13/9376	1.25105077056508	MRE11/XRCC5	0.339164875710647
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/1153	86/9376	1.04011779180702	LAMA2/RYR2/DTNA/CACNB4/ACTB/ITGB5/CACNA2D3/ITGA9/GJA1/SGCE/SGCG	0.139946981479445
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	10/1153	78/9376	1.04254230880423	CR1/CYBB/CYBA/NCF4/PRKCB/FCGR1A/FCGR3A/MAPK3/TLR4/MAP3K7	0.141272858540918
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	8/1153	62/9376	1.04926838821587	RBPJ/TLE4/MAML2/APH1B/CIR1/PSENEN/CTBP1/RFNG	0.145740826975087
NA	NA	hsa04519	Cadherin signaling	50/1153	404/9376	1.00641460503379	WNT2/PCDH12/CDH11/GABRA3/PRICKLE1/ACTB/ADAM10/ARPC3/TMC8/EGFR/ARPC1B/STK3/PCDH10/SCN1B/GJA1/MYO7A/VAV3/CYFIP1/APH1B/NCKAP1L/MAP2K2/ROCK2/ENAH/AFDN/APC/RERE/EVL/VAV1/YAP1/PCDH18/MAPK3/PSENEN/KRT1/BRK1/FZD2/FZD5/PPP1CA/ANKRD6/LRP6/MYO1B/TMC6/MPDZ/MYO1F/YWHAB/FZD3/PPP1CC/ARPC1A/CDH5/ATN1/ARHGAP35	0.0493515863987209
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	18/1153	144/9376	1.01647875108413	WNT2/IGF1/BMPR1A/BMP4/MAP2K2/PIK3CD/APC/DUSP9/JAK3/MAPK3/SMAD5/FZD2/FZD5/SMARCAD1/FZD3/ID1/FGFR3/ACVR2A	0.074617859822307
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	11/1153	87/9376	1.02816241488969	EGFR/MAP2K2/PIK3CD/MSH3/APC/SOS1/BAX/MAPK3/CCND1/BAD/MSH2	0.0988166629961896
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1153	14/9376	1.161690001239	FUT8/ST3GAL3	0.226698168010036
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	13/1153	105/9376	1.0067980010738	RPS27A/UBA52/PRKN/TOMM7/GABARAPL2/HIF1A/MTX2/FIS1/RHOT1/RAB5C/AMBRA1/MAP1LC3A/VCP	0.0262299664176872
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	13/1153	105/9376	1.0067980010738	ITPR2/PPP3CA/CALML4/CALM2/NFATC2/SYK/FCER1G/PPP3R1/PIK3CD/PYCARD/CALM3/MAPK3/NFATC3	0.0262299664176872
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	17/1153	139/9376	0.99454036077296	ITPR2/EGFR/CALML4/NCOA2/CALM2/KCNJ5/MAP2K2/NCOA1/PIK3CD/GNAI2/CREB1/ATF6B/SOS1/CALM3/MAPK3/GPER1/PLCB1	-0.0242823671018299
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1153	23/9376	1.06067347939213	ATP6AP2/NLN/PRCP	0.10908687439617
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	25/1153	205/9376	0.99168658642354	RBPJ/HDAC9/SCIN/HDAC8/SKP2/DLG1/RB1/LYN/CCND2/SYK/PIK3CD/CREB1/RASA2/JAK3/ATF6B/BAX/MAPK3/CDKN2A/CCND1/BAD/RBL2/CDK6/RANBP1/YWHAB/UBR4	-0.045064350583229
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/1153	98/9376	0.995734286776289	ITPR2/ATP1B1/PRKCA/CALML4/CALM2/PRKCB/KCNJ5/CREB1/ATF6B/CALM3/ATP2B4/PLCB1	-0.0158950777184454
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	14/1153	115/9376	0.989961914099325	ITPR2/GNG2/GNG10/GNGT1/GNG12/GNG11/PRKCA/PRKCB/KCNJ5/GNAI2/GNB2/GNG5/MAPK3/PLCB1	-0.0405560857484317
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	7/1153	57/9376	0.998645790538793	ELOVL2/CBR4/HSD17B12/SCP2/ACADS/HACD3/HADHB	-0.00383993402208559
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1153	15/9376	1.0842440011564	AK1/ACP1	0.122266826227888
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	12/1153	99/9376	0.98567636468764	ITPR2/HRH1/IGF1/PRKCA/CALML4/CALM2/PRKCB/PIK3CD/CALM3/PPP1CA/PLCB1/PPP1CC	-0.0536478375270106
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1153	49/9376	0.995734286776289	GRIN2C/GNAI2/CREB1/BDNF/ATF6B/CDK5	-0.0112099545970058
Human Diseases	Substance dependence	hsa05034	Alcoholism	23/1153	191/9376	0.979225603138637	GNG2/HDAC9/GNG10/GRIN2C/HDAC8/GNGT1/GNG12/GNG11/CALML4/CALM2/GNAI2/CREB1/GNB2/BDNF/ATF6B/SOS1/GNG5/CALM3/MAPK3/PPP1CA/SLC29A3/PPP1CC/HAT1	-0.108615216918955
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	16/1153	133/9376	0.978265264201266	HCST/PRKCA/PPP3CA/NFATC2/SYK/PRKCB/VAV3/FCER1G/PPP3R1/MAP2K2/PIK3CD/SH3BP2/SOS1/FCGR3A/VAV1/MAPK3	-0.0945276488704431
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1153	24/9376	1.01647875108413	HS2ST1/GLCE/B3GAT3	0.0302665425011534
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	28/1153	233/9376	0.977215623359849	COL3A1/LAMA2/COL1A1/DCN/ATP1B1/COL1A2/ANK2/DTNA/ACTB/ITGB5/NEBL/COL6A1/ITGA9/TNNT3/COL5A2/CAPZA2/CAPZB/DIAPH2/COL5A1/CAPZA1/SGCE/COL6A2/FBLN1/TNNT1/MYH10/CSRP2/SGCG/TLN2	-0.131873003762195
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/1153	67/9376	0.970964777154988	AKR1A1/ACSS1/LDHB/PDHB/ADH5/ALDH9A1/ALDH7A1/DLD	-0.0893091994601985
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/1153	33/9376	0.98567636468764	PDHB/BCKDHB/IDH2/DLD	-0.0308639990787594
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/1153	43/9376	0.945561628915468	ADH5/ALDH9A1/ACADS/HADHB/ALDH7A1	-0.133971945242569
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	11/1153	95/9376	0.941580316793719	CCL2/CD28/CD86/ANGPT1/ATP6V0B/ATP6V0A1/CCL5/TNFRSF11A/MMP1/ATP6V1G1/TLR4	-0.214293382806062
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	19/1153	163/9376	0.947882025550843	RB1/PRKCA/NFATC2/PRKCB/MAP2K2/PIK3CD/CREB1/JAK3/ATF6B/SOS1/MAP3K1/BAX/MAPK3/BAD/TLR4/YWHAB/MAP3K7/NFATC3/MAP2K7	-0.251342506630155
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1153	26/9376	0.938288077923811	SLC46A1/ABCD4/PLB1	-0.11798725258645
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1153	17/9376	0.956685883373297	INMT/MTR	-0.066930542528314
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	16/1153	138/9376	0.942820870570786	PYGL/MKNK1/RPS6/CALML4/CALM2/PHKB/MAP2K2/PIK3CD/SOS1/CALM3/PRKAR1A/MAPK3/BAD/PPP1CA/PPP1CC/PHKA1	-0.253380535560657
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/1153	44/9376	0.924071591894662	GTF2I/TAF15/GTF2H5/MNAT1/TAF3	-0.189028990307953
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/1153	44/9376	0.924071591894662	DCTN4/DYNC2H1/CREB1/RAB5C/DCTN6	-0.189028990307953
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	14/1153	122/9376	0.933160820667397	ITPR2/CSH1/IGF1/PRKCA/PRKCB/MAP2K2/PIK3CD/GNAI2/CREB1/ATF6B/SOS1/MAP3K1/MAPK3/PLCB1	-0.278247597630419
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	12/1153	105/9376	0.929352000991203	LAMA2/RYR2/DTNA/CACNB4/IGF1/ACTB/ITGB5/CACNA2D3/ITGA9/SGCE/SGCG/ADRB1	-0.272594049538853
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	8/1153	71/9376	0.91626253618851	CCND2/MAP2K2/PIK3CD/SOS1/TNFRSF11A/MAPK3/CCND1/CGA	-0.265201475154529
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/1153	71/9376	0.91626253618851	ADAM10/LYN/EGFR/JAM3/ATP6V0B/ATP6V0A1/CCL5/ATP6V1G1	-0.265201475154529
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1153	36/9376	0.903536667630336	GALNT1/C1GALT1/GALNT10/C1GALT1C1	-0.217132693486433
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1153	27/9376	0.903536667630336	HMGCLL1/ACADS/HMGCL	-0.187951895373812
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/1153	18/9376	0.903536667630336	FUCA1/NEU1	-0.15338826658552
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1153	18/9376	0.903536667630336	ABCD4/MTR	-0.15338826658552
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/1153	55/9376	0.887108728218876	SGMS1/PLPP3/NEU1/DEGS1/ACER3/SGPP1	-0.314409458858671
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	11/1153	99/9376	0.903536667630336	LAMA2/RYR2/DTNA/CACNB4/IGF1/ACTB/ITGB5/CACNA2D3/ITGA9/SGCE/SGCG	-0.36129439694796
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1153	19/9376	0.855982106176108	HYAL2/NAGLU	-0.235293585527611
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/1153	56/9376	0.871267500929253	CR1/CD14/PYCARD/NAIP/TLR4/VCP	-0.361792370583848
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/1153	38/9376	0.855982106176108	AMDHD2/GALK2/FPGT/RENBP	-0.333093735943004
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	21/1153	187/9376	0.913200161401784	ITPR2/CCL2/CYBB/CYBA/PKN2/IFI16/GABARAPL2/CCL5/PYCARD/ANTXR1/TRPM2/NAIP/TXN2/MAPK3/GPSM3/PLCB1/TLR4/PKN1/MAP3K7/MAP1LC3A/RBCK1	-0.448942521891106
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/1153	29/9376	0.841223794000658	STK3/RASSF4/YAP1	-0.320651624476571
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/1153	75/9376	0.867395200925123	ITPR2/ATP1B1/PRKCA/PRKCB/CREB1/ATF6B/CGA/PLCB1	-0.431727982133316
NA	NA	hsa03272	Virion - Hepatitis viruses	5/1153	48/9376	0.84706562590344	EGFR/CD63/DPP4/CLDN5/CHMP4A	-0.397755878355912
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	10/1153	93/9376	0.874390323513229	IL12RB2/RBPJ/MAF/MAML2/PPP3CA/NFATC2/PPP3R1/JAK3/MAPK3/NFATC3	-0.455832769228837
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	10/1153	93/9376	0.874390323513229	LAMA2/SKP2/RB1/RARB/PIK3CD/LAMC1/LAMC3/BAX/CCND1/CDK6	-0.455832769228837
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	15/1153	137/9376	0.890346351314565	ITPR2/CTSC/TUBA1B/ACTB/ATM/TNFRSF1A/MAP2K2/PIK3CD/MAP3K5/BAX/MAPK3/BAD/TUBA1A/CAPN1/PARP1	-0.484123354639786
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1153	20/9376	0.813183000867303	NPL/CMAS	-0.313163710150317
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1153	10/9376	0.813183000867303	SELENBP1	-0.221321936580411
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	11/1153	103/9376	0.868447865003915	PABPN1/PNN/UPF2/SAP18/PABPC4L/SRRM1/FIP1L1/PPP1CA/PPP2R5E/UPF3A/PPP1CC	-0.502679911493891
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/1153	59/9376	0.826965763593867	PRKG1/PIK3CD/GNAI2/CGA/ABHD5/ADRB1	-0.499235138657005
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1153	31/9376	0.786951291161906	AKR1A1/ALDH9A1/ALDH7A1	-0.444892666823266
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/1153	32/9376	0.762359063313096	TNFRSF1A/BIRC6/BAX	-0.504214088695205
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/1153	160/9376	0.864006938421509	CD28/PTPRD/CADM3/PTPRM/CD99/CD86/ITGA9/JAM3/LRRC4/PTPRC/NRCAM/CLDN5/SIGLEC1/GLG1/NCAM2/SLITRK4/CDH5	-0.649666773866483
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1153	12/9376	0.677652500722752	NCAM2	-0.418378513555066
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1153	23/9376	0.707115652928089	ATP1B1/MDH1	-0.52658654657244
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	11/1153	109/9376	0.820643395370672	CD36/PYGL/TBC1D4/TNFRSF1A/PRKCB/PIK3CD/CREB1/MLXIP/OGA/PPP1CA/PPP1CC	-0.705255022930679
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	16/1153	154/9376	0.844865455446548	SHMT1/AKR1A1/NME3/NME2/NME4/AK1/PPCDC/QPRT/COQ7/ALAS2/AK9/NADK2/COQ2/HAAO/NME7/DLD	-0.726844424206955
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/1153	100/9376	0.813183000867303	CXCL14/CCL2/CCL4L2/CSF1R/TNFRSF1A/CCL13/CCL5/CCR1/CCL8/PPBP	-0.703268504818598
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1153	63/9376	0.774460000826003	HPGDS/PTGDS/GPX4/TBXAS1/LTC4S/PLB1	-0.6725648937783
NA	NA	hsa04082	Neuroactive ligand signaling	21/1153	199/9376	0.858132814985596	GNG2/GNG10/GRIN2C/HRH1/GRIA4/GNGT1/GABRA3/GNG12/GNG11/PRKCA/HRH2/PRKCB/TAC3/GNAI2/GNB2/SLC1A1/GNG5/OGFRL1/PLCB1/ADRB1/P2RY13	-0.757431339340507
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/1153	44/9376	0.73925727351573	CD28/ICA1/PTPRN2/CD86	-0.649136937641121
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	12/1153	119/9376	0.820016471462826	CCL2/MAP3K8/TNFRSF1A/PIK3CD/CCL5/CREB1/ATF6B/MAP3K5/MAPK3/BAG4/MAP3K7/MAP2K7	-0.739871429857171
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	18/1153	173/9376	0.846086359283899	CCL2/ACTB/TNFRSF1A/PRKCA/SLC25A4/PRKCB/MAP2K2/SLC25A6/PABPN1/PIK3CD/CCL5/PYCARD/TLR7/SLC25A5/BAX/MAPK3/CDK6/TLR4	-0.765104221994146
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/1153	73/9376	0.779764521379605	BICD1/FEZ1/PPIA/MLLT1/CHMP4A/SMARCB1/PIN1	-0.707330440732304
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/1153	35/9376	0.697014000743402	ENOSF1/FPGT/PFKFB2	-0.672426845238524
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/1153	37/9376	0.659337568270786	GALK2/FPGT/CMAS	-0.777427794189138
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/1153	48/9376	0.677652500722752	ATP1B1/PRKCB/PIK3CD/PLCB1	-0.838370140580041
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1153	15/9376	0.542122000578202	ST3GAL5	-0.664537403499412
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	14/1153	144/9376	0.790594584176544	CD14/LY96/TNFRSF1A/TRA2A/C3AR1/MAP3K5/CCND1/ADH5/ALDH9A1/IL17RA/TLR4/MAP3K7/MAP2K7/ALDH7A1	-0.948214090022652
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	22/1153	217/9376	0.824425162169616	MGST2/RB1/PRKCA/EGFR/PRKCB/FGF7/MAP2K2/PIK3CD/GNAI2/PAQR7/CREB1/MGST3/ATF6B/SOS1/GSTA4/MAPK3/CCND1/BAD/FGF10/ARNT/ADRB1/ARRB1	-0.97983570292487
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1153	38/9376	0.641986579632081	JAK3/PTPRC/RFXANK	-0.828036187322023
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1153	79/9376	0.720541899502673	HPGDS/MGST2/MGST3/GSTA4/GSTK1/ADH5/AKR7A2	-0.93399377064017
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/1153	28/9376	0.580845000619502	ATP6V0A1/ATP6V1G1	-0.831724435613841
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/1153	70/9376	0.697014000743402	HPGDS/MGST2/MGST3/SULT1A1/GSTA4/GSTK1	-0.952741763992658
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1153	16/9376	0.508239375542064	NAGA	-0.737158648734954
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	15/1153	156/9376	0.781906731603176	TNFRSF1A/RB1/EGFR/PIAS1/MAP2K2/PIK3CD/EIF3E/SOS1/BAX/MAPK3/CLDN5/CCND1/BAD/CDK6/YWHAB	-1.02854724759885
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/1153	90/9376	0.722829334104269	IGF1/CAT/PIK3CD/SESN3/CREB1/ATF6B/BAX/EHMT1	-0.989325781932744
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	10/1153	110/9376	0.73925727351573	IGF1/CPEB4/PIK3CD/ANAPC11/GNAI2/MAPK3/ANAPC1/CDC16/ANAPC10/CDC27	-1.03002447375935
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	16/1153	168/9376	0.774460000826003	PYGL/CYBB/TNFRSF1A/SLC25A4/SLC25A6/PYCARD/JAK3/SLC25A5/BAX/PPIA/CHMP2A/CHMP4A/TLR4/CAPN1/PARP1/RBCK1	-1.10453811457883
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1153	17/9376	0.478342941686649	CSAD	-0.806083389107196
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1153	17/9376	0.478342941686649	CA8	-0.806083389107196
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/1153	17/9376	0.478342941686649	MYH10	-0.806083389107196
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	9/1153	102/9376	0.717514412529973	ITPR2/ATP1B1/RYR2/PRKCA/PRKCB/KCNQ1/CFTR/ATP2B4/PLCB1	-1.074108075233
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1153	41/9376	0.595011951854124	GRIN2C/GRIA4/GABRA3	-0.973110414682665
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/1153	112/9376	0.726056250774377	LAMA2/LY96/TNFRSF1A/GNAI2/LAMC1/LAMC3/MAPK3/BAD/TLR4/MAP3K7	-1.09208459289411
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/1153	52/9376	0.625525385282541	HSD17B2/IGF1/CGA/HSD17B1	-1.01393022330532
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/1153	30/9376	0.542122000578202	PIGN/DPM2	-0.940551677520888
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/1153	83/9376	0.685816988683267	CCL4L2/IFI16/CCL5/PYCARD/POLR2K/POLR2E/POLR2L	-1.07653690423211
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/1153	73/9376	0.668369589753947	HPGDS/MGST2/MGST3/GSTA4/GSTK1/ADH5	-1.06509762055137
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/1153	18/9376	0.451768333815168	CBR4	-0.871754094510514
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/1153	31/9376	0.524634194107937	PGLS/RBKS	-0.992668588574406
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/1153	43/9376	0.567336977349281	CD36/PLPP3/AGPAT2	-1.06477665705756
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/1153	86/9376	0.661893140240828	ATP1B1/RYR2/PRKCA/PRKCB/CREB1/ATF6B/PLCB1	-1.17945261465054
Human Diseases	Infectious disease: viral	hsa05162	Measles	12/1153	136/9376	0.717514412529973	CD28/CCND2/RACK1/PIK3CD/JAK3/TLR7/BAX/CCND1/BAD/CDK6/TLR4/MAP3K7	-1.24255296533491
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/1153	46/9376	0.530336739696067	BLVRB/ALAS2/BLVRA	-1.1956658607975
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/1153	100/9376	0.650546400693842	CD36/CR1/CD14/CSF1R/EPOR/FCGR1A/KITLG/CD33	-1.31551042693366
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	10/1153	122/9376	0.666543443333855	CD36/IGF1/PIK3CD/CREB1/RAB2A/CFTR/CCND1/PPP2R5E/PFKFB2/MAP3K7	-1.38816015895048
NA	NA	hsa04081	Hormone signaling	20/1153	219/9376	0.742632877504386	GNG2/GNG10/GNGT1/CSH1/PRKG1/IGF1/GNG12/GNG11/EPOR/BMPR1A/PIK3CD/GNAI2/GNB2/GNG5/CGA/SMAD5/THRA/GPER1/PLCB1/ADRB1	-1.44305759188615
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1153	36/9376	0.451768333815168	CRYL1/AKR1A1	-1.23403385938493
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/1153	36/9376	0.451768333815168	PYGL/ENPP1	-1.23403385938493
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/1153	103/9376	0.631598447275575	CCL2/TNFRSF1A/PIK3CD/GNAI2/CCL5/MAPK3/PLCB1/TLR4	-1.40771611135948
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/1153	23/9376	0.353557826464045	ARG2	-1.16225996754105
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/1153	23/9376	0.353557826464045	PDSS2	-1.16225996754105
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1153	37/9376	0.439558378847191	RIMKLB/ASPA	-1.27898721057374
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/1153	61/9376	0.533234754667084	ATP1B1/ATOX1/SLC46A1/ATP2B4	-1.36948457891477
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	14/1153	168/9376	0.677652500722752	IL12RB2/CSH1/PIAS2/EGFR/EPOR/CCND2/PIAS1/PIK3CD/JAK3/SOS1/CCND1/PIM1/STAM2/STAM	-1.57863394694886
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1153	39/9376	0.417016923521694	CD28/CD86	-1.3660598230268
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/1153	52/9376	0.469144038961905	CD36/PLTP/TSPO	-1.43734950772143
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/1153	65/9376	0.500420308226032	ITPR2/CREB1/ATF6B/PLCB1	-1.51338155822178
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1153	26/9376	0.31276269264127	PLB1	-1.31393155556002
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1153	26/9376	0.31276269264127	HHEX	-1.31393155556002
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/1153	88/9376	0.554442955136797	F13A1/CR1/C4BPB/PROS1/VTN/C3AR1	-1.57242048947326
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/1153	54/9376	0.451768333815168	CENPX/RPA3/ATR	-1.51283510745387
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/1153	54/9376	0.451768333815168	CD28/CD86/CGA	-1.51283510745387
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	17/1153	205/9376	0.674346878768007	RBPJ/SKP2/RB1/LYN/CCND2/SYK/PIK3CD/SEM1/CIR1/JAK3/BAX/CCND1/SAP30L/CDK6/MAP3K7/MAP2K7/PSMC2	-1.76526119971649
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/1153	28/9376	0.290422500309751	ST3GAL3	-1.40800645662444
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/1153	28/9376	0.290422500309751	PCBD2	-1.40800645662444
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/1153	94/9376	0.519052979277002	CCL2/S100A9/MMP1/MAPK3/IL17RA/MAP3K7	-1.75479153315114
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/1153	45/9376	0.361414667052135	CD28/CD86	-1.60785265944629
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1153	30/9376	0.271061000289101	PLB1	-1.49735256958023
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/1153	72/9376	0.451768333815168	MAP3K1/RNF125/PIN1/MAP3K7	-1.74856049058085
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/1153	47/9376	0.346035319518001	PIK3CD/MAPK3	-1.68294848562561
Human Diseases	Immune disease	hsa05310	Asthma	1/1153	32/9376	0.254119687771032	FCER1G	-1.5825697674375
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	7/1153	109/9376	0.522227615235883	PPP3CA/NFATC2/PPP3R1/HIF1A/JAK3/MAPK3/NFATC3	-1.87866722203419
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	28/1153	323/9376	0.704926440380324	FSCN1/ATM/PRKCA/EGFR/CCND2/PDCD4/PRKCB/ABL1/MAP2K2/ZEB2/PIK3CD/APC/DNMT3A/SOS1/EFNA5/MDM4/MMP16/RECK/MAPK3/CDKN2A/CCND1/PIM1/EFNA4/CDK6/STMN1/FZD3/UBE2I/FGFR3	-2.02078655413634
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/1153	62/9376	0.393475645580953	IGF1/CAT/PIK3CD	-1.79415978875236
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/1153	75/9376	0.433697600462561	SHMT1/ARG2/MTR/IDH2	-1.84373864245667
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/1153	99/9376	0.49283818234382	FCAR/FCGR1A/FCGR3A/C3AR1/FPR2/PTAFR	-1.89952719405271
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/1153	76/9376	0.427991053088054	CD36/PLTP/SCP2/MMP1	-1.87479285759602
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/1153	50/9376	0.325273200346921	CD28/CD86	-1.79122607916941
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/1153	66/9376	0.369628636757865	HSD17B2/HSD17B12/HSD17B1	-1.92432645142158
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/1153	66/9376	0.369628636757865	IL12RB2/MAF/TLR4	-1.92432645142158
Genetic Information Processing	Transcription	hsa03040	Spliceosome	19/1153	243/9376	0.63582209944357	SRSF9/TRA2A/SRSF10/LSM8/LSM4/SF3B6/DDX46/CWC15/LSM3/LSM7/SNRPE/LSM6/SNRPD3/SNRPF/SF1/CDC40/SF3B5/SNRPC/SNRPG	-2.15374926683433
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/1153	37/9376	0.219779189423595	ADH5	-1.78054662695833
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1153	86/9376	0.378224651566187	SCN9A/GABRA3/PKD1L3/PLCB1	-2.16900231174803
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	12/1153	180/9376	0.542122000578202	CCL2/TNFRSF1A/POU2F2/SYK/PIK3CD/CCL5/SRSF9/BAX/BAD/PPP1CA/PPP1CC/MAP3K7	-2.32258541546857
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/1153	90/9376	0.361414667052135	ATP1B1/ABCG2/ABCC4/CFTR	-2.27934991535899
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	22/1153	298/9376	0.600336443593311	CXCL14/IL12RB2/CCL2/BMP5/EDA/CCL4L2/CSF1R/CSH1/TNFRSF25/TNFRSF1A/EPOR/BMPR1A/BMP4/CCL13/CCL5/TNFRSF11A/CCR1/IL17RA/CCL8/PPBP/GDF6/ACVR2A	-2.62538341970003
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/1153	82/9376	0.297505975927062	LGMN/CREB1/RFXANK	-2.39239768229575
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/1153	70/9376	0.232338000247801	CD36/TNFRSF1A	-2.41391895859398
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/1153	68/9376	0.119585735421662	ADH5	-2.72833997468497
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/1153	143/9376	0.284329720582973	CD28/CD86/FCGR1A/FCGR3A/SNRPD3	-3.22919840826299
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	23/1153	370/9376	0.505492135674269	GRIN2C/SPX/HRH1/GRIA4/GABRA3/CSH1/HRH2/TAC3/TSPO/LPAR6/KISS1/LYPD6/C3AR1/FPR2/CGA/THRA/OGFRL1/PTGFR/CYSLTR1/ADRB1/PTAFR/LTB4R/P2RY13	-3.63406959550186
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	7/1153	183/9376	0.311053606889132	NOP10/RPP25/NVL/IMP3/XRN2/RIOK2/RCL1	-3.5242563612418
NA	NA	hsa04382	Cornified envelope formation	7/1153	217/9376	0.262317097053969	S100A9/CLDN5/KRT1/S100A1/ABHD5/PPP2R5E/CAPN1	-4.11680884730224
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/1153	449/9376	0.108665879848637	PRKG1/GRK3/CALML4/CALM2/CALM3/ARRB1	-7.24763112505905