category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	151/1974	222/9376	3.2306835711091	RPS23/RPLP1/RPS12/RPS11/RPS27A/RPS18/RPL27A/RPS19/RPL23A/RPS15/RPL26/RPL10/RPL32/RPL14/RPS14/RPL30/RPL11/RPL23/RPL7A/RPS4X/RPL13/RPS9/RPL13A/RPL35/RPL19/RPS15A/RPS2/UBA52/RPL10A/FAU/RPL28/RPS24/RPL15/RPL12/RPL21/RPL27/RPS7/RPL6/RPL29/RPL22/RPL24/RPL3/RPS25/RPL34/RPS6/RPS20/RPL18/RPS3A/RPS10/RPL17/RPS8/RPL9/RPL5/RPL18A/RPLP0/RPL35A/RPL7/RPS5/RACK1/RPL8/RPL37/RPS16/RPL36A/RPL36/RPS13/RPL36AL/RPL31/RPS26/RPSA/RPL39/RPS3/RPLP2/RPL41/MRPL51/MRPS21/RPS17/RPS27L/MRPL20/RPL37A/RPS28/RPS21/RPL38/RPL22L1/RPL4/MRPS24/MRPL14/RSL24D1/MRPL32/MRPL52/MRPS6/MRPL41/MRPL54/MRPL33/MRPL18/MRPS18C/MRPL27/MRPL13/MRPL40/MRPS15/MRPL11/MRPL22/MRPL28/MRPS26/RPL26L1/MRPS33/MRPL16/MRPS16/MRPS25/MRPS34/MRPL42/MRPS28/MRPL21/MRPL17/MRPL43/MRPL3/MRPS31/MRPS23/MRPS7/DAP3/MRPS22/MRPL19/MRPL46/MRPL34/MRPL15/MRPL38/MRPL50/MRPL36/MRPS14/MRPL55/MRPS18A/MRPL47/MRPS10/MRPS18B/MRPL4/MRPL12/MRPS12/MRPS11/MRPL45/MRPL1/MRPL44/MRPL9/MRPL35/MRPS30/MRPL2/MRPL37/MRPS9/MRPL24/MRPS35/MRPS17/MRPL23/MRPL30	17.3697542448814
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	148/1974	268/9376	2.6229944502412	RPS27A/ATP5F1E/COX6C/MT-CO2/UQCR10/UQCRB/UBA52/NDUFA4/NDUFA13/TUBA1B/UQCR11/COX4I1/COX5B/ATP5MC2/NDUFC2/COX7C/CALM1/NDUFA1/COX6B1/NDUFS5/COX8A/CALM2/COX7B/SLC25A6/COX6A1/UBB/ATP5MC3/UQCRH/NDUFB2/COX7A2/GNAI2/MT-ATP6/MT-CYB/NDUFA2/ATP5PF/PARK7/ATP5F1D/CALM3/NDUFB11/NDUFA11/NDUFB7/NDUFS6/ATP5PD/UQCRQ/PSMA7/PSMB1/NDUFB10/NDUFB8/NDUFV2/ATP5F1C/NDUFB4/PSMA2/TUBB/ATP5F1A/PSMB3/NDUFAB1/NDUFC1/NDUFB3/NDUFB5/SLC25A5/SEM1/PSMA1/PSMA4/ITPR1/PSMB4/COX7A2L/ATP5PO/NDUFA12/PSMB6/ATP5F1B/ITPR2/ATP5MC1/VDAC1/GNAS/SDHD/BAX/HSPA5/NDUFB1/PSMA5/PSMA3/VDAC2/PSMB5/KIF5B/NDUFS4/ATP5PB/NDUFA6/NDUFS7/COX5A/PSMC5/PSMD8/SLC39A13/UQCRC2/NDUFA5/UBE2L3/PSMB7/PSMC3/PSMA6/NDUFA7/NDUFB9/NDUFA3/PSMC6/PSMB2/NDUFA8/UQCRFS1/PSMD4/NDUFS8/CYCS/COX4I2/VDAC3/PSMD9/TUBA1A/TXN2/PSMC2/PSMD3/NDUFA10/CYC1/UBE2J1/PSMD12/CALML4/SDHB/PSMC4/UBE2J2/NDUFV1/NDUFS3/SLC39A4/PRKACB/NDUFV3/NDUFB6/PSMD2/PRKN/ADRM1/MT-CO3/PRKACA/NDUFA9/MT-ND2/PSMD6/NDUFA4L2/MAPK10/TRAP1/UBE2L6/MT-ND1/SLC25A4/TP53/MAPT/APAF1/HTRA2/SLC39A3/UBA7	13.9205884078038
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	147/1974	275/9376	2.53895551257253	C1QA/ATP5F1E/COX6C/CYBA/MT-CO2/UQCR10/UQCRB/NDUFA4/NDUFA13/CYBB/TUBA1B/UQCR11/COX4I1/COX5B/ATP5MC2/NDUFC2/C1QB/COX7C/RYR2/C1QC/NDUFA1/COX6B1/NDUFS5/COX8A/COX7B/SLC25A6/COX6A1/ATP5MC3/UQCRH/NDUFB2/COX7A2/MT-ATP6/MT-CYB/NDUFA2/ATP5PF/ATP5F1D/NDUFB11/NDUFA11/NDUFB7/NDUFS6/ATP5PD/UQCRQ/PSMA7/PSMB1/NDUFB10/NDUFB8/NDUFV2/ATP5F1C/NDUFB4/PSMA2/TUBB/ATP5F1A/PSMB3/NCF4/NDUFAB1/NDUFC1/NDUFB3/NDUFB5/SLC25A5/SEM1/PSMA1/EGR1/PSMA4/ITPR1/PSMB4/COX7A2L/ATP5PO/NDUFA12/PSMB6/ATP5F1B/ITPR2/ATP5MC1/VDAC1/SDHD/BAX/HSPA5/NDUFB1/PSMA5/PSMA3/VDAC2/PSMB5/KIF5B/NDUFS4/ATP5PB/NDUFA6/NDUFS7/COX5A/PSMC5/PSMD8/CSNK2B/UQCRC2/NDUFA5/PSMB7/PSMC3/PSMA6/NDUFA7/NDUFB9/NDUFA3/PSMC6/PSMB2/PPP3R1/NDUFA8/UQCRFS1/PSMD4/NDUFS8/CYCS/COX4I2/VDAC3/PSMD9/TUBA1A/CREB1/PSMC2/PSMD3/NDUFA10/C6/CYC1/BAD/PSMD12/SDHB/PSMC4/NDUFV1/NDUFS3/PRKACB/NCF2/NDUFV3/NDUFB6/PSMD2/ADRM1/MT-CO3/PRKACA/NDUFA9/PIK3CD/MT-ND2/TNF/PSMD6/NDUFA4L2/MAPK10/NCAM2/GRIN2C/MT-ND1/SLC25A4/RAC2/RYR1/PIK3R3/MAPK13/PIK3R2/APAF1	13.3761930287589
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	158/1974	308/9376	2.4365583757681	ATP5F1E/COX6C/MT-CO2/UQCR10/UQCRB/NDUFA4/NDUFA13/TUBA1B/CLTA/UQCR11/COX4I1/COX5B/ATP5MC2/NDUFC2/COX7C/NDUFA1/COX6B1/POLR2L/AP2S1/NDUFS5/COX8A/CLTC/COX7B/SLC25A6/COX6A1/ATP5MC3/UQCRH/NDUFB2/COX7A2/MT-ATP6/MT-CYB/NDUFA2/ATP5PF/ATP5F1D/NDUFB11/NDUFA11/NDUFB7/NDUFS6/ATP5PD/UQCRQ/PSMA7/PSMB1/NDUFB10/NDUFB8/PLCB1/NDUFV2/ATP5F1C/NDUFB4/PSMA2/TUBB/ATP5F1A/PSMB3/AP2M1/POLR2K/NDUFAB1/NDUFC1/NDUFB3/NDUFB5/SLC25A5/SEM1/PSMA1/PSMA4/ITPR1/PSMB4/COX7A2L/ATP5PO/NDUFA12/PSMB6/ATP5F1B/ATP5MC1/VDAC1/SDHD/BAX/NDUFB1/PSMA5/PSMA3/DCTN3/VDAC2/PSMB5/KIF5B/NDUFS4/ATP5PB/NDUFA6/GPX7/NDUFS7/COX5A/PSMC5/POLR2E/PSMD8/POLR2J/UQCRC2/NDUFA5/POLR2F/PSMB7/PSMC3/PSMA6/NDUFA7/POLR2I/NDUFB9/NDUFA3/PSMC6/PSMB2/DNAH8/DCTN4/BDNF/POLR2G/NDUFA8/UQCRFS1/PSMD4/DCTN6/NDUFS8/CYCS/COX4I2/VDAC3/PSMD9/TUBA1A/CREB1/PSMC2/PSMD3/NDUFA10/CYC1/PSMD12/NRBF2/GPX8/SDHB/PSMC4/TFAM/DCTN1/NDUFV1/NDUFS3/HDAC2/NDUFV3/NDUFB6/PSMD2/ADRM1/MT-CO3/DCTN2/GRIA4/HDAC1/ACTR1A/NDUFA9/MT-ND2/PSMD6/NDUFA4L2/MAPK10/PLCB2/MT-ND1/POLR2C/SLC25A4/TP53/PIK3R4/APAF1/ATG101/DLG4/DNAL4/TRAF2/SLC1A2/DNALI1	13.2381577850646
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	93/1974	138/9376	3.20091625919563	ATP5F1E/COX6C/MT-CO2/UQCR10/UQCRB/ATP5MG/NDUFA4/NDUFA13/UQCR11/COX4I1/COX5B/ATP5MF/ATP5MC2/NDUFC2/COX7C/NDUFA1/COX6B1/ATP6V1G1/NDUFS5/COX8A/COX7B/COX6A1/ATP5MC3/UQCRH/NDUFB2/COX7A2/ATP6V1F/MT-ATP6/MT-CYB/NDUFA2/ATP5PF/ATP5F1D/NDUFB11/NDUFA11/ATP5ME/NDUFB7/ATP6V0B/NDUFS6/ATP5PD/UQCRQ/NDUFB10/NDUFB8/NDUFV2/ATP5F1C/NDUFB4/ATP5F1A/NDUFAB1/NDUFC1/NDUFB3/NDUFB5/COX17/COX7A2L/ATP5PO/NDUFA12/ATP5F1B/ATP6V0E1/ATP5MC1/SDHD/NDUFB1/NDUFS4/ATP5PB/NDUFA6/ATP6V1D/NDUFS7/COX5A/UQCRC2/NDUFA5/NDUFA7/NDUFB9/NDUFA3/NDUFA8/UQCRFS1/NDUFS8/CYCS/COX4I2/NDUFA10/ATP6V1A/CYC1/SDHB/NDUFV1/NDUFS3/NDUFV3/NDUFB6/MT-CO3/ATP6V1H/NDUFA9/PPA2/MT-ND2/NDUFA4L2/MT-ND1/TCIRG1/COX15/COX11	13.450510102146
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	116/1974	205/9376	2.68766155138755	ATP5F1E/COX6C/CYBA/COL3A1/MT-CO2/UQCR10/UQCRB/NDUFA4/NDUFA13/CYBB/COL1A2/UQCR11/COX4I1/COX5B/ATP5MC2/NDUFC2/COX7C/RYR2/COL1A1/NDUFA1/COX6B1/NDUFS5/COX8A/COX7B/SLC25A6/COX6A1/ATP5MC3/UQCRH/NDUFB2/COX7A2/MT-ATP6/MT-CYB/NDUFA2/ATP5PF/ATP5F1D/NDUFB11/CD36/NDUFA11/NDUFB7/NDUFS6/ATP5PD/UQCRQ/MMP2/NDUFB10/NDUFB8/PLCB1/NDUFV2/ATP5F1C/NDUFB4/ATP5F1A/NCF4/NDUFAB1/NDUFC1/NDUFB3/NDUFB5/SLC25A5/COX7A2L/ATP5PO/NDUFA12/ATP5F1B/ATP5MC1/PPP1CA/VDAC1/SDHD/NDUFB1/VDAC2/NDUFS4/ATP5PB/NDUFA6/NDUFS7/COX5A/MPC2/UQCRC2/NDUFA5/NDUFA7/NDUFB9/NDUFA3/PDHB/NDUFA8/UQCRFS1/NDUFS8/PRKCB/MPC1/COX4I2/VDAC3/NDUFA10/PARP1/CYC1/SDHB/NDUFV1/NDUFS3/TBC1D4/NCF2/NDUFV3/NDUFB6/MT-CO3/PPP1CC/NDUFA9/PIK3CD/MT-ND2/NDUFA4L2/MAPK10/PLCB2/SLC2A1/MT-ND1/PTPA/CPT2/SLC25A4/RAC2/G6PD/TGFB3/PIK3R3/MAPK13/PIK3R2/PDK2/AGTR1	12.6164918684431
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	123/1974	238/9376	2.45470102934791	F13A1/RPS23/RPLP1/CCL2/RPS12/RPS11/C1QA/RPS27A/RPS18/CFD/RPL27A/RPS19/RPL23A/RPS15/RPL26/RPL10/NRP1/RPL32/RPL14/RPS14/RPL30/RPL11/RPL23/RPL7A/RPS4X/RPL13/RPS9/RPL13A/RPL35/RPL19/RPS15A/RPS2/UBA52/RPL10A/FAU/RPL28/RPS24/RPL15/RPL12/RPL21/CYBB/RPL27/RPS7/RPL6/RPL29/RPL22/RPL24/RPL3/RPS25/RPL34/C1QB/RPS6/RPS20/RPL18/C1QC/RPS3A/RPS10/RPL17/RPS8/RPL9/RPL5/RPL18A/RPLP0/RPL35A/RPL7/RPS5/RPL8/RPL37/RPS16/RPL36A/C1R/RPL36/RPS13/RPL36AL/RPL31/RPS26/RPSA/RPL39/RPS3/RPLP2/RPL41/RPS17/RPS27L/RPL37A/RPS28/RPS21/RPL38/RPL22L1/RPL4/CXCL8/FCGR2A/C3AR1/TNFRSF1A/RSL24D1/C2/CASP1/SYK/PRKCB/JUN/C6/RPL26L1/ADAR/NLRP3/STAT2/MMP1/IFNAR2/IRF9/TLR4/PIK3CD/TNF/TLR7/MAPK10/IRAK1/ISG15/IKBKG/IRAK4/CHUK/PIK3R3/MAPK13/PIK3R2/TRAF3/AGTR1/IFIH1	11.738735572838
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	121/1974	235/9376	2.44561426200177	ATP5F1E/COX6C/MT-CO2/UQCR10/UQCRB/ATP5MG/NDUFA4/NDUFA13/UQCR11/COX4I1/COX5B/ATP5MF/ATP5MC2/NDUFC2/RPS6/COX7C/NDUFA1/COX6B1/NDUFS5/COX8A/COX7B/COX6A1/ATP5MC3/UQCRH/NDUFB2/COX7A2/MT-ATP6/MT-CYB/NDUFA2/ATP5PF/ATP5F1D/NDUFB11/NDUFA11/ATP5ME/NDUFB7/NDUFS6/ATP5PD/UQCRQ/NDUFB10/NDUFB8/NDUFV2/ATP5F1C/NDUFB4/ATP5F1A/NDUFAB1/NDUFC1/NDUFB3/NDUFB5/COX17/COX7A2L/ATP5PO/NDUFA12/ATP5F1B/COX14/ATP5MC1/GNAS/SDHD/NDUFB1/GRB2/NDUFS4/ATP5PB/NDUFA6/NDUFAF3/NDUFS7/COX5A/UQCRC2/NDUFA5/NDUFA7/COX16/SMARCE1/SMARCB1/NDUFB9/NDUFA3/COA1/NDUFA8/UQCRFS1/NDUFS8/COA4/COX4I2/PRKG1/CREB1/NDUFA10/NDUFAF8/CYC1/COA3/SDHB/HRAS/NDUFV1/NDUFS3/PRKACB/NDUFV3/NDUFB6/SMARCA4/MT-CO3/COX20/RPS6KB2/MGLL/SMARCD1/COA5/PRKACA/NDUFA9/KRAS/MT-ND2/NDUFA4L2/CPT1A/ADCY7/MT-ND1/COA6/TSC2/NRAS/CPT2/COX15/MLST8/COX11/ACTL6A/MAPK13/NDUFAF4/RPS6KA1/COA7/NDUFAF1/SMARCD3	11.5897527981886
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	197/1974	480/9376	1.94937521107734	RPS27A/ATP5F1E/COX6C/MT-CO2/UQCR10/UQCRB/UBA52/WNT2/NDUFA4/NDUFA13/CYBB/TUBA1B/UQCR11/COX4I1/COX5B/ATP5MC2/NDUFC2/COX7C/RYR2/CALM1/NDUFA1/COX6B1/NDUFS5/COX8A/CALM2/COX7B/SLC25A6/COX6A1/UBB/ATP5MC3/UQCRH/NDUFB2/COX7A2/MT-ATP6/MT-CYB/NDUFA2/ATP5PF/PARK7/ATP5F1D/CALM3/NDUFB11/NDUFA11/NDUFB7/NDUFS6/ATP5PD/UQCRQ/PSMA7/PSMB1/NDUFB10/NDUFB8/PLCB1/NDUFV2/ATP5F1C/NDUFB4/PSMA2/TUBB/ATP5F1A/PSMB3/NDUFAB1/NDUFC1/NDUFB3/NDUFB5/SLC25A5/SEM1/PSMA1/PSMA4/ITPR1/PSMB4/FZD4/COX7A2L/MAP2K2/ATP5PO/NDUFA12/PSMB6/ATP5F1B/ITPR2/ATP5MC1/VDAC1/VCP/SDHD/BAX/HSPA5/NDUFB1/TNFRSF1A/PSMA5/PSMA3/DCTN3/VDAC2/PSMB5/KIF5B/NDUFS4/ATP5PB/NDUFA6/GPX7/NDUFS7/COX5A/PSMC5/PSMD8/CSNK2B/UQCRC2/NDUFA5/UBE2L3/PSMB7/PSMC3/PSMA6/CSF1/TNFRSF1B/NDUFA7/NDUFB9/NDUFA3/PSMC6/PSMB2/PPP3R1/DNAH8/DCTN4/BDNF/CCS/NDUFA8/UQCRFS1/PSMD4/DCTN6/NDUFS8/CYCS/PRKCB/HSD17B10/COX4I2/VDAC3/PSMD9/TUBA1A/PSMC2/PSMD3/NDUFA10/CYC1/UBE2J1/BAD/CAT/SPG11/PSMD12/RAB8A/NRBF2/GPX8/CALML4/APC/SDHB/PSMC4/DVL3/HRAS/UBE2J2/DCTN1/NDUFV1/NDUFS3/BID/LRP6/NDUFV3/NDUFB6/PSMD2/PRKN/ADRM1/AXIN2/MT-CO3/DCTN2/WNT5B/CAPN1/GRIA4/ACTR1A/NDUFA9/KRAS/MT-ND2/TNF/PSMD6/NDUFA4L2/MAPK10/TRAP1/UBE2L6/PLCB2/GRIN2C/MT-ND1/MAP2K6/NRAS/SLC25A4/PIK3R4/FIG4/RYR1/MAPT/PPID/MAPK13/APAF1/HTRA2/ATG101/DLG4/DNAL4/UBA7/TRAF2/WNT10A/WNT11/DNALI1/BAK1	11.0267058980969
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	161/1974	368/9376	2.07801418439716	ATP5F1E/COX6C/MT-CO2/UQCR10/UQCRB/NDUFA4/NDUFA13/TUBA1B/PFN1/UQCR11/COX4I1/COX5B/ATP5MC2/NDUFC2/COX7C/NDUFA1/COX6B1/NDUFS5/COX8A/COX7B/COX6A1/ATP5MC3/UQCRH/NDUFB2/COX7A2/MT-ATP6/MT-CYB/NDUFA2/ATP5PF/ATP5F1D/NDUFB11/NDUFA11/NDUFB7/NDUFS6/ATP5PD/UQCRQ/PSMA7/PSMB1/NDUFB10/NDUFB8/NDUFV2/ATP5F1C/NDUFB4/PSMA2/TUBB/ATP5F1A/PSMB3/NDUFAB1/NDUFC1/NDUFB3/NDUFB5/SEM1/PSMA1/PSMA4/PSMB4/COX7A2L/ATP5PO/NDUFA12/HNRNPA3/PSMB6/ATP5F1B/ATP5MC1/HNRNPA1/VDAC1/VCP/SDHD/BAX/HSPA5/NDUFB1/TNFRSF1A/PSMA5/PSMA3/DCTN3/ANXA11/PSMB5/KIF5B/NDUFS4/ATP5PB/NDUFA6/GPX7/NDUFS7/COX5A/PSMC5/PSMD8/CASP1/UQCRC2/NDUFA5/PSMB7/PSMC3/PSMA6/TNFRSF1B/NDUFA7/NDUFB9/NDUFA3/PSMC6/PSMB2/PPP3R1/DNAH8/DCTN4/CHCHD10/CCS/NDUFA8/UQCRFS1/PSMD4/DCTN6/NDUFS8/CYCS/COX4I2/PSMD9/TUBA1A/PSMC2/PSMD3/NDUFA10/CYC1/BAD/CAT/SPG11/PSMD12/RAB8A/NRBF2/GPX8/SEC13/ALYREF/SDHB/PSMC4/DCTN1/NDUFV1/NDUFS3/BID/NDUFV3/NDUFB6/PSMD2/PRKN/ADRM1/MT-CO3/DCTN2/ACTR1A/NDUFA9/MT-ND2/TNF/PSMD6/NDUFA4L2/GRIN2C/MT-ND1/NUP62/RAE1/MAP2K6/TP53/PIK3R4/FIG4/NUP107/PFN2/MAPK13/APAF1/ATG101/NUP37/GLE1/DNAL4/TRAF2/SLC1A2/DNALI1	10.8947901088578
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	167/1974	388/9376	2.04434974252917	ATP5F1E/COX6C/MT-CO2/UQCR10/UQCRB/WNT2/NDUFA4/NDUFA13/CYBB/TUBA1B/UQCR11/COX4I1/COX5B/ATP5MC2/NDUFC2/COX7C/CALM1/NDUFA1/COX6B1/NDUFS5/COX8A/CALM2/COX7B/SLC25A6/COX6A1/ATP5MC3/UQCRH/NDUFB2/COX7A2/MT-ATP6/MT-CYB/NDUFA2/ATP5PF/ATP5F1D/CALM3/NDUFB11/NDUFA11/NDUFB7/NDUFS6/ATP5PD/UQCRQ/PSMA7/PSMB1/NDUFB10/NDUFB8/PLCB1/NDUFV2/ATP5F1C/NDUFB4/PSMA2/TUBB/ATP5F1A/PSMB3/NDUFAB1/NDUFC1/NDUFB3/NDUFB5/SLC25A5/SEM1/PSMA1/PSMA4/ITPR1/PSMB4/FZD4/COX7A2L/MAP2K2/ATP5PO/NDUFA12/PSMB6/APOE/ATP5F1B/ITPR2/ATP5MC1/LRP1/VDAC1/SDHD/NDUFB1/TNFRSF1A/PSMA5/PSMA3/VDAC2/PSMB5/KIF5B/NDUFS4/ATP5PB/NDUFA6/NDUFS7/COX5A/PSMC5/PSMD8/SLC39A13/CSNK2B/UQCRC2/NDUFA5/PSMB7/PSMC3/PSMA6/CSF1/NDUFA7/NDUFB9/NDUFA3/PSMC6/PSMB2/PPP3R1/NDUFA8/UQCRFS1/PSMD4/NDUFS8/CYCS/HSD17B10/COX4I2/VDAC3/PSMD9/TUBA1A/PSMC2/PSMD3/NDUFA10/CYC1/BAD/PSMD12/NRBF2/CALML4/APC/SDHB/PSMC4/DVL3/HRAS/NDUFV1/NDUFS3/SLC39A4/BID/LRP6/NDUFV3/NDUFB6/PSMD2/ADRM1/AXIN2/MT-CO3/PSENEN/WNT5B/CAPN1/NDUFA9/KRAS/PIK3CD/MT-ND2/TNF/PSMD6/NDUFA4L2/MAPK10/PLCB2/GRIN2C/MT-ND1/NRAS/IKBKG/SLC25A4/PIK3R4/CHUK/MAPT/PIK3R3/PPID/PIK3R2/APAF1/ATG101/SLC39A3/TRAF2/WNT10A/WNT11	10.8496309749665
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	114/1974	227/9376	2.38533535074917	ATP5F1E/COX6C/CYBA/MT-CO2/UQCR10/UQCRB/NDUFA4/NDUFA13/HGF/UQCR11/COX4I1/COX5B/ATP5MC2/NDUFC2/COX7C/NDUFA1/COX6B1/NDUFS5/COX8A/COX7B/SLC25A6/COX6A1/ATP5MC3/UQCRH/NDUFB2/COX7A2/MT-ATP6/MT-CYB/NDUFA2/ATP5PF/ATP5F1D/NDUFB11/NDUFA11/NDUFB7/NDUFS6/ATP5PD/UQCRQ/NDUFB10/NDUFB8/NDUFV2/ATP5F1C/NDUFB4/ATP5F1A/MGST3/NDUFAB1/NDUFC1/NDUFB3/NDUFB5/SLC25A5/COX7A2L/MAP2K2/ATP5PO/NDUFA12/ATP5F1B/HIF1A/ATP5MC1/VDAC1/PLD1/SDHD/MGST2/NDUFB1/GRB2/VDAC2/NDUFS4/ATP5PB/AKR1A1/NDUFA6/GSTO1/NDUFS7/COX5A/PTPRJ/UQCRC2/NDUFA5/NDUFA7/NDUFB9/NDUFA3/ACP1/NDUFA8/UQCRFS1/NDUFS8/JUN/COX4I2/VDAC3/NDUFA10/CYP1A2/CYC1/BAD/CAT/SDHB/HRAS/NDUFV1/NDUFS3/NCF2/NDUFV3/NDUFB6/MT-CO3/NDUFA9/KRAS/PIK3CD/MT-ND2/NDUFA4L2/MAPK10/MT-ND1/NRAS/IKBKG/SLC25A4/GSTA4/CHUK/CBR1/PIK3R3/MAPK13/PIK3R2/NQO1/PLD2	10.9110288324232
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	79/1974	157/9376	2.3899999354668	COX6C/MT-CO2/UQCR10/UQCRB/NDUFA4/NDUFA13/UQCR11/COX4I1/COX5B/NDUFC2/COX7C/NDUFA1/COX6B1/NDUFS5/COX8A/COX7B/COX6A1/UQCRH/NDUFB2/COX7A2/MT-CYB/NDUFA2/NDUFB11/NDUFA11/NDUFB7/NDUFS6/UQCRQ/NDUFB10/NDUFB8/NDUFV2/NDUFB4/NDUFAB1/NDUFC1/NDUFB3/NDUFB5/COX7A2L/NDUFA12/CXCL8/SDHD/BAX/NDUFB1/CDC42/TNFRSF1A/NDUFS4/NDUFA6/NDUFS7/COX5A/UQCRC2/NDUFA5/NDUFA7/NDUFB9/NDUFA3/NDUFA8/UQCRFS1/NDUFS8/CYCS/JUN/COX4I2/NDUFA10/CYC1/SDHB/NDUFV1/NDUFS3/BID/NDUFV3/NDUFB6/MT-CO3/NDUFA9/PIK3CD/TNF/NDUFA4L2/MAPK10/MAP3K11/MLX/CEBPA/PIK3R3/MAPK13/PIK3R2/TRAF2	9.07000174875619
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	34/1974	46/9376	3.51068234879521	PSMA7/PSMB1/PSMA2/PSMB3/POMP/PSMB8/SEM1/PSMA1/PSMA4/PSMB4/PSMB6/PSME1/PSMA5/PSMA3/PSMB5/PSMC5/PSMD8/PSMB7/PSMC3/PSMA6/PSMC6/PSME2/PSMB2/PSMD4/PSMD9/PSMC2/PSMD3/PSMD12/PSMC4/PSMB10/PSMB9/PSMD2/ADRM1/PSMD6	8.81484206063788
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	62/1974	149/9376	1.97640467010737	NDUFA4/NDUFA13/GNGT1/GNG10/NDUFC2/NDUFA1/NDUFS5/GNG5/NDUFB2/GNG2/GNAI2/GNG11/NDUFA2/NDUFB11/NDUFA11/NDUFB7/NDUFS6/NDUFB10/NDUFB8/PLCB1/NDUFV2/NDUFB4/NDUFAB1/NDUFC1/NDUFB3/NDUFB5/ITPR1/NDUFA12/ITPR2/GNB2/NDUFB1/NDUFS4/NDUFA6/NDUFS7/NDUFA5/NDUFA7/NDUFB9/NDUFA3/NDUFA8/NDUFS8/PRKCB/NDUFA10/GNB4/GNG7/NDUFV1/NDUFS3/PRKACB/NDUFV3/NDUFB6/MGLL/GRIA4/PRKACA/KCNJ5/NDUFA9/MT-ND2/NDUFA4L2/MAPK10/PLCB2/ADCY7/MT-ND1/MAPK13/GABRA3	6.20408006514171
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	89/1974	250/9376	1.69090982776089	LGMN/CTSC/CD63/CLTA/NPC2/VAMP8/AP2S1/ATP6V1G1/CLTC/BLOC1S1/ATP6V1F/LAMTOR4/ATP6V0B/CTSZ/ASAH1/CD68/AP2M1/LAMTOR1/LAMTOR5/LAPTM5/VPS29/ATP6V0E1/NEU1/AP1S2/ATP6V1D/LAMTOR2/FUCA2/LAPTM4B/OSBPL1A/M6PR/SUMF1/SCARB2/BORCS7/FUCA1/ARSB/AP1B1/MAN2B1/CTBS/BLOC1S6/GAA/RRAGA/ATP6V1A/MANBA/SPG11/HYAL2/WDR7/GLB1/CLN6/VPS16/SLC15A3/ACP2/PPT1/KXD1/MCOLN2/CLCN7/NAGLU/CTSO/ATP6V1H/NAGA/GLA/BLOC1S2/GNPTG/TLR7/DTNBP1/GUSB/OSBPL6/SMPD1/BLOC1S4/BORCS5/AP4E1/GPR155/BORCS8/AP3M1/TCIRG1/AP5S1/FIG4/TELO2/VPS11/SNAPIN/MLST8/MFSD8/AP1S1/BLOC1S5/TMEM175/ROGDI/SLC29A3/VPS26B/AP4M1/TFEB	5.71789023958155
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	56/1974	144/9376	1.84712371946414	SLC25A6/PSMA7/PSMB1/PLCB1/PSMA2/PSMB3/SLC25A5/SEM1/PSMA1/PSMA4/ITPR1/PSMB4/PSMB6/ITPR2/VDAC1/PSMA5/PSMA3/VDAC2/PSMB5/PSMC5/PSMD8/PSMB7/PSMC3/PSMA6/RBPJ/PSMC6/PSMB2/PSMD4/CYCS/PRKCB/GTF2B/VDAC3/PSMD9/PSMC2/PSMD3/NOP56/PSMD12/NRBF2/PSMC4/PSMD2/ADRM1/PIK3CD/PSMD6/MAPK10/PLCB2/GRIN2C/SLC25A4/PIK3R4/RYR1/OMA1/PIK3R3/PIK3R2/ATG101/CIC/MYOD1/TRAF2	5.29011194464234
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	82/1974	248/9376	1.57048076608818	CD14/S100A10/TUBA1B/PFN1/ARPC3/ARPC1B/LY96/RPS3/DYNLL1/BRK1/MYL12B/TUBB/ARPC2/DYNLT1/ARPC5/ACTR2/MAP2K2/PTPRC/CXCL8/RAB5C/PYCARD/DYNLRB1/MYL12A/CYTH4/BAX/CDC42/TNFRSF1A/DCTN3/KIF5B/ELMO1/CASP1/M6PR/HSP90B1/NCKAP1L/RAB9A/CYFIP1/DCTN4/DCTN6/ARPC4/CYCS/RIPK1/JUN/RHOG/TUBA1A/ARPC1A/TXN2/TNFRSF10B/DYNLL2/GSDMD/HRAS/NLRP3/DCTN1/VPS16/TRADD/PKN1/DYNC1LI1/ARPC5L/DCTN2/TLR4/ACTR1A/PIK3CD/PIK3CG/TNF/MAPK10/IRAK1/EXOC7/CYTH2/MAP2K6/IKBKG/RIPK2/PAK1/IRAK4/CHUK/VPS11/PFN2/MAPK13/TCF7/ELMO2/DYNC2LI1/TRAF2/TIRAP/BAK1	4.70179514658463
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	67/1974	196/9376	1.62363790501003	RPS27A/HLA-C/UBA52/GNGT1/GNG10/CALM1/CALM2/GNG5/UBB/GNG2/GNG11/CDK6/CALM3/ITPR1/LYN/MAP2K2/CD86/CXCL8/HIF1A/ITPR2/GNB2/RB1/BAX/TNFRSF1A/CCR1/SYK/CCND1/PPP3R1/CYCS/JUN/CLEC2B/CREB1/NFATC3/ICAM1/GNB4/CD200R1/ATG3/HCK/CALML4/GNG7/HRAS/BID/STAT2/TRADD/IFNAR2/IRF9/PREX1/CDK4/KRAS/PIK3CD/PIK3CG/MAPK10/PIK3R5/E2F3/MAP2K6/NRAS/IKBKG/TP53/CHUK/PIK3R3/MAPK13/PIK3R2/TCF7/TRAF3/MICA/TRAF2/BAK1	4.55642127494807
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	81/1974	250/9376	1.5389179331307	DAB2/HLA-C/FOLR2/CLTA/ARPC3/SNX6/WWP1/AP2S1/CLTC/ARPC1B/SNX3/SNX2/CAPZB/CHMP5/ARPC2/AP2M1/PSD3/CHMP2A/VPS28/CAPZA2/ARPC5/ACTR2/VPS29/RAB5C/BIN1/ACAP2/CYTH4/PLD1/EPS15/CDC42/KIF5B/ARF4/RAB11A/SNF8/ZFYVE16/ARF5/EHD4/ARPC4/ARAP1/SNX5/ARPC1A/ARRB2/WASHC3/VPS25/VPS36/CHMP4A/VTA1/GIT2/STAMBP/RAB8A/GRK2/ARF3/GRK3/HRAS/SH3GL1/VPS4A/PML/EPN1/RNF41/FGFR4/ARPC5L/ZFYVE27/RAB11FIP2/MVB12A/ARRB1/FGFR2/VPS45/MVB12B/RAB4A/SH3KBP1/ARAP2/EPS15L1/RUFY1/CYTH2/SNX12/SH3GLB2/GIT1/IL2RA/FGFR3/VPS26B/PLD2	4.46002280756371
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	69/1974	205/9376	1.59869523315294	B2M/HLA-C/CCND2/CDK6/CALR/SEM1/PDIA3/LYN/RB1/BAX/PSMC5/PSMD8/SYK/PSMC3/CCND1/RBPJ/PSMC6/PSMD4/CYCS/RIPK1/JUN/PSMC2/PSMD3/ICAM1/PSMD12/PSMC4/HLA-DPA1/CDKN1B/BID/STAT2/TRADD/HDAC2/PSMD2/ADRM1/IFNAR2/IRF9/JAK3/CDK4/HDAC1/TAPBP/PIK3CD/SKP2/TNF/PSMD6/MAPK10/IRAK1/ISG15/HLA-DQA2/E2F3/MAP2K6/IKBKG/DDB2/TP53/IRAK4/HLA-DMA/CHUK/SAP30L/PIK3R3/MAPK13/PIK3R2/APAF1/TRAF3/CD40/BTK/TAP2/CCNE1/TRAF2/BAK1/BLNK	4.47568028941555
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	73/1974	224/9376	1.54790852511217	B2M/HLA-C/NRP1/CCND2/SLC25A6/RAN/ANAPC11/CALR/TSPO/SLC25A5/EGR1/MAP2K2/VDAC1/RB1/BAX/RANBP1/TNFRSF1A/DLG1/VDAC2/ANAPC16/SPI1/CCND1/CD4/XPO1/PPP3R1/ATM/JUN/CDKN2A/VDAC3/ANAPC10/CREB1/NFATC3/ICAM1/HRAS/HLA-DPA1/PRKACB/MAP3K1/FDPS/ANAPC13/JAK3/CDK4/CDC26/EGR2/ATR/PRKACA/KRAS/PIK3CD/CHEK2/TNF/MAPK10/ADCY7/SLC2A1/HLA-DQA2/E2F3/NRAS/IKBKG/SLC25A4/TP53/VAC14/HLA-DMA/CDC23/CHUK/CCNB2/TGFB3/PIK3R3/CDKN2C/PIK3R2/ANAPC15/IL2RA/MSX1/PTTG1/CD40/CCNE1	4.28606480508372
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	69/1974	214/9376	1.53146038689884	B2M/HLA-C/GNGT1/ELOB/GNG10/CALM1/CFL1/CALM2/GNG5/GNG2/GNAI2/GNG11/CALM3/RBX1/BST2/CALR/RNF7/PDIA3/ITPR1/MAP2K2/ELOC/ITPR2/AP1S2/GNB2/BAX/TNFRSF1A/CD4/TNFRSF1B/PPP3R1/ATM/CYCS/PRKCB/RIPK1/JUN/AP1B1/NFATC3/GNB4/BAD/CALML4/GNG7/HRAS/BID/TRADD/RPS6KB2/TLR4/ATR/TAPBP/KRAS/PIK3CD/TNF/MAPK10/IRAK1/APOBEC3C/MAP2K6/NRAS/IKBKG/RAC2/PAK1/IRAK4/CHUK/CCNB2/PIK3R3/AP1S1/MAPK13/PIK3R2/TAP2/TRAF2/CDK1/BAK1	4.06132097700514
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	25/1974	57/9376	2.08322223999716	ELOVL2/HADHB/SCP2/HADHA/CBR4/ECHS1/ACADVL/HACD4/PPT1/HSD17B4/HSD17B12/FADS1/CPT1A/ACADM/HACD3/ACAA1/ACADS/CPT2/SCD5/ACAT2/ELOVL1/FADS2/ACOX3/HADH/MECR	4.23599083732369
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	30/1974	75/9376	1.89989868287741	CCND2/CDK6/SIVA1/IGF1/BAX/CCNG1/CCND1/SHISA5/PMAIP1/ATM/CYCS/EI24/CDKN2A/CCNG2/TNFRSF10B/SESN3/ZMAT3/BID/CD82/CDK4/ATR/AIFM2/CHEK2/TSC2/DDB2/TP53/CCNB2/APAF1/CCNE1/CDK1	4.04058360819629
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	16/1974	31/9376	2.45148217145472	SRP14/SEC61B/SEC11A/SEC61G/SPCS1/SRP9/SPCS2/HSPA5/TMEM208/SEC61A1/SRP19/SPCS3/GET3/SEC11C/OXA1L/SRPRB	4.18010866581718
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	71/1974	227/9376	1.48560359564202	CCL3/CCL2/B2M/CCL4/HLA-C/CCL4L2/GNGT1/GNG10/CCL3L1/CALM1/CALM2/GNG5/GNG2/GNAI2/GNG11/CDK6/CALM3/PLCB1/CALR/PDIA3/ITPR1/MAP2K2/CXCL8/ITPR2/GNB2/RB1/GNAS/BAX/TNFRSF1A/GRB2/CCR1/CCND1/PPP3R1/CYCS/PRKCB/RIPK1/CDKN2A/CREB1/NFATC3/GNB4/CALML4/GNG7/HRAS/PRKACB/BID/TRADD/IL10RA/RPS6KB2/CDK4/PRKACA/TAPBP/KRAS/PIK3CD/PTGER4/TNF/PLCB2/ADCY7/TSC2/E2F3/MAP2K6/NRAS/IKBKG/TP53/RAC2/CHUK/PIK3R3/MAPK13/PIK3R2/TAP2/TRAF2/BAK1	3.8246586505666
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	36/1974	98/9376	1.7448049128466	FCGR3A/ARPC3/MARCKS/CFL1/ARPC1B/ARPC2/ARPC5/WASF2/ACTR2/LYN/PTPRC/BIN1/FCGR2A/PLD1/CDC42/FCGR1A/SYK/PLPP3/ARPC4/PRKCB/VAV1/ARPC1A/HCK/WAS/ARPC5L/SCIN/INPP5D/RPS6KB2/PIK3CD/VAV3/RAC2/PAK1/PIK3R3/PIK3R2/MARCKSL1/PLD2	3.82748113134199
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	47/1974	138/9376	1.61766735679779	CCL2/ARPC3/ARPC1B/ARPC2/FYB1/ARPC5/WASF2/ACTR2/MAP2K2/CXCL8/PYCARD/FCGR2A/CDC42/ELMO1/CASP1/CD4/ARPC4/JUN/LCP2/VAV1/RHOG/ARPC1A/NFATC3/GIT2/WAS/NLRP3/PKN1/ARPC5L/SKAP2/TLR4/PIK3CD/TNF/MAPK10/IRAK1/VAV3/MAP2K6/IKBKG/RAC2/IRAK4/CHUK/PIK3R3/MAPK13/PIK3R2/RPS6KA1/ELMO2/ITGA4/TRAF2	3.77476470886305
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	41/1974	116/9376	1.67878978443909	PGLS/ESD/SDHD/ADH5/GCSH/MDH1/ECHS1/PDHB/MDH2/TKT/DLD/IDH2/PGAM1/SUCLG1/CAT/ME2/SDHB/IDH3G/GPI/ME1/PFKL/SUCLA2/HIBCH/RPIA/ACADS/SHMT2/CS/RPE/PHGDH/FH/G6PD/ACAT2/PCCB/DLAT/GOT1/GCK/PRPS1/MCEE/ACOX3/PGP/GOT2	3.79877412309003
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	30/1974	78/9376	1.82682565661289	CD14/C1QA/C1QB/C1QC/CALM1/CFL1/CALM2/GNAI2/C1R/CALM3/LY96/CXCL8/PYCARD/C2/CASP1/JUN/C4BPB/CALML4/NLRP3/ITGAM/TLR4/IRF1/TNF/MAPK10/IRAK1/IRAK4/IRF8/MAPK13/TICAM2/TIRAP	3.78661496425867
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	37/1974	105/9376	1.67372026824914	CD14/CCL4/CCL4L2/LY96/VCAM1/LYN/CXCL8/EDA/TNFRSF1A/UBE2I/CSNK2B/SYK/ATM/PRKCB/RIPK1/PARP1/TNFSF13B/ICAM1/TRADD/TNFRSF11A/PLAU/CCL13/BCL2A1/TLR4/TNF/IRAK1/IKBKG/IRAK4/CHUK/TRIM25/TRAF3/TICAM2/CD40/BTK/TRAF2/TIRAP/BLNK	3.58505352328726
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	28/1974	73/9376	1.82182065481395	HGF/CDK6/EML4/RARB/MAP2K2/RB1/BAX/GRB2/KIF5B/CCND1/PRKCB/CDKN2A/BAD/HRAS/JAK3/CDK4/KRAS/PIK3CD/E2F3/NRAS/DDB2/TP53/PIK3R3/PIK3R2/RASSF1/RASSF5/TGFA/BAK1	3.64008599514836
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	50/1974	154/9376	1.54212555428361	NME2/GGCX/NME4/AKR1A1/GCLM/PTS/MOCS2/PPCS/PMM1/HAAO/NME3/DLD/RDH11/BCAT1/AFMID/UROD/KYNU/PPCDC/MMAB/AK1/IDO2/GUSB/NME1/UROS/COQ2/SHMT2/GGH/MOCS1/UMPS/QPRT/PANK1/COQ4/COX15/TPK1/CMPK2/FLAD1/GSS/COQ5/FECH/NQO1/ALAS1/LIAS/IDO1/NAPRT/GMPPA/MPI/NME6/COQ6/COQ7/COASY	3.50293720981903
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	29/1974	77/9376	1.78886564296899	CDK6/RUNX1/MAP2K2/RB1/BAX/GRB2/CCND1/CDKN2A/SHC1/BAD/HRAS/CDKN1B/HDAC2/CTBP1/CDK4/HDAC1/KRAS/PIK3CD/E2F3/NRAS/IKBKG/DDB2/TP53/CHUK/TGFB3/PIK3R3/PIK3R2/MECOM/BAK1	3.58934292409621
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	22/1974	54/9376	1.93508199181958	LDHB/ADI1/GCLM/MDH1/MDH2/SMS/AHCYL2/DNMT3A/APIP/BCAT1/SRM/KYAT3/CISD1/ENOPH1/LACC1/TST/MTAP/PHGDH/GSS/GOT1/MRI1/GOT2	3.55857969082763
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	50/1974	157/9376	1.5126581870043	HLA-C/CCND2/CALM1/CALM2/SLC25A6/CDK6/CALM3/SLC25A5/ITPR1/MAP2K2/CXCL8/ITPR2/PPP1CA/VDAC1/RB1/VDAC2/CCND1/PPP3R1/ATM/RAD1/CDKN2A/VDAC3/NFATC3/RBL2/CALML4/HRAS/PPP1CC/CAPN1/CDK4/ATR/KRAS/PIK3CD/CHEK2/TSC2/E2F3/MAP2K6/NRAS/SLC25A4/TP53/CCNB2/TGFB3/PIK3R3/PPID/MAPK13/PIK3R2/LIN37/NBN/RASSF5/CCNE1/CDK1	3.34518767519344
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	31/1974	87/9376	1.69243848187355	COX6C/MT-CO2/UQCR10/UQCRB/UQCR11/COX4I1/COX5B/COX7C/RYR2/COX6B1/COX8A/COX7B/COX6A1/UQCRH/COX7A2/MT-CYB/TPM3/UQCRQ/ATP1B3/ATP1B1/COX7A2L/ASPH/COX5A/UQCRC2/UQCRFS1/COX4I2/CYC1/CACNB4/CACNA2D4/MT-CO3/MYL3	3.35074217766215
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	24/1974	63/9376	1.8094273170261	POLR2L/RBX1/POLR2K/GTF2H5/POLR2E/POLR2J/POLR2F/POLR2I/RAD23A/POLR2G/RPA3/POLE4/XPA/PCNA/ERCC3/POLD2/POLR2C/DDB2/ERCC8/UVSSA/GTF2H3/RFC3/RFC4/ERCC4	3.32880229622304
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	14/1974	30/9376	2.21654846335697	SDHD/MDH1/PDHB/MDH2/DLD/IDH2/SUCLG1/SDHB/IDH3G/SUCLA2/ACLY/CS/FH/DLAT	3.44636939943064
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	30/1974	85/9376	1.67638119077418	NME2/ENPP1/APRT/GUK1/DUT/NME4/NT5C/ITPA/HDDC2/DGUOK/NME3/IMPDH2/GMPR/NUDT16/AK1/NME1/DCK/TK2/GMPR2/LACC1/TYMS/DTYMK/ADA2/UCK1/CMPK2/AMPD2/IMPDH1/DCTPP1/NME6/NTPCR	3.23485208212058
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	64/1974	216/9376	1.40733235768697	CD14/CCL3/CCL2/CYBA/CYBB/CCL3L1/CALM1/CALM2/CALM3/LY96/CD36/PLCB1/VCAM1/NCF4/ITPR1/LYN/CXCL8/PYCARD/BAX/HSPA5/CDC42/TNFRSF1A/CASP1/POU2F2/HSP90B1/PPP3R1/CYCS/JUN/VAV1/NFATC3/ICAM1/TNFRSF10B/BAD/CALML4/HRAS/NLRP3/BID/NCF2/MMP1/TLR4/HSPA4/KRAS/PIK3CD/TNF/MAPK10/PLCB2/IRAK1/VAV3/MAP2K6/NRAS/IKBKG/TP53/IRAK4/CHUK/MIB2/PIK3R3/MAPK13/PIK3R2/APAF1/TRAF3/TICAM2/CD40/TRAF2/TIRAP	3.12761092646897
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	58/1974	193/9376	1.42738502081463	CXCL14/CCL3/CCL2/CCL4/CCL4L2/GNGT1/GNG10/CCL3L1/GNG5/GNG2/GNAI2/GNG11/PLCB1/LYN/CXCL8/GNB2/CDC42/GRB2/CCR1/ELMO1/DOCK2/CCL8/PRKCB/VAV1/SHC1/ARRB2/GNB4/BAD/HCK/GRK2/WAS/GRK3/GNG7/HRAS/PRKACB/STAT2/CXCL16/CCL13/JAK3/PREX1/PRKACA/KRAS/PIK3CD/PIK3CG/ARRB1/PLCB2/ADCY7/VAV3/PIK3R5/CX3CR1/NRAS/IKBKG/RAC2/PAK1/CHUK/PIK3R3/PIK3R2/CCL28	3.09806361391454
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	25/1974	68/9376	1.74623040705644	CD14/RUNX1T1/CSF1R/RUNX1/MAP2K2/DUSP6/GRB2/FCGR1A/SPI1/CCND1/BAD/HRAS/PML/ITGAM/BCL2A1/RPS6KB2/KRAS/PIK3CD/NRAS/IKBKG/CHUK/CEBPA/PIK3R3/PIK3R2/TCF7	3.18921562027097
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	18/1974	44/9376	1.94307819839735	DYNLL1/RAB5C/GNAS/RAB11A/ARHGDIB/DCTN4/DCTN6/CREB1/VAMP2/DYNLL2/DCTN1/PRKACB/NSF/DYNC1LI1/DCTN2/PRKACA/STX4/DYNC2LI1	3.23795903767769
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	14/1974	31/9376	2.14504690002288	GCSH/GRHPR/MDH1/MDH2/DLD/CAT/AFMID/SHMT2/CS/HYI/ACAT2/PCCB/MCEE/PGP	3.29760886057294
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	30/1974	87/9376	1.6378436921357	MAP2K2/BAX/GRB2/CCND1/PMAIP1/CYCS/AREG/APPL1/JUN/BAD/APC/HRAS/AXIN2/RPS6KB2/RALB/KRAS/PIK3CD/MSH3/MAPK10/NRAS/DDB2/TP53/RAC2/TGFB3/PIK3R3/PIK3R2/TCF7/MSH2/TGFA/BAK1	3.08655543841528
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	14/1974	32/9376	2.07801418439716	LDHB/HADHA/ECHS1/ECHDC1/DLD/ACACB/SUCLG1/SUCLA2/HIBCH/ACSS3/ACADS/PCCB/MCEE/ACOX3	3.15440695449964
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	11/1974	23/9376	2.2716179903969	IDI1/FDPS/PMVK/ICMT/NUS1/GGPS1/DHDDS/MVD/ACAT2/PCYOX1/FNTB	3.15304222186787
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	32/1974	97/9376	1.56692674876487	GNGT1/GNG10/RYR2/CALM1/CALM2/GNG5/GNG2/GNAI2/GNG11/CALM3/PLCB1/GUCY1A2/ITPR1/GNB2/GNAS/GUCY1A1/NOS1AP/PRKCB/PRKG1/CREB1/GNB4/CALML4/GNG7/PRKACB/GRIA4/PRKACA/KCNJ5/PLCB2/ADCY7/GRIN2C/RYR1/PER3	2.89832378012014
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	33/1974	101/9376	1.55189743898402	CCL2/COL3A1/CYBB/COL1A2/COL1A1/MMP2/PLCB1/VCAM1/EGR1/CXCL8/BAX/CDC42/CCND1/PLCD3/PRKCB/JUN/VEGFB/ICAM1/HRAS/CDKN1B/CDK4/KRAS/PIK3CD/TNF/MAPK10/PLCB2/NRAS/COL4A4/TGFB3/PIK3R3/MAPK13/PIK3R2/AGTR1	2.87969689758717
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	34/1974	105/9376	1.53801321947219	FCER1G/CALM1/CALM2/CALM3/ITPR1/LSP1/ITPR2/PYCARD/CASP1/SYK/PPP3R1/CLEC7A/CD209/JUN/NFATC3/CALML4/HRAS/NLRP3/STAT2/IRF9/EGR2/KRAS/PIK3CD/IRF1/TNF/MAPK10/NRAS/IKBKG/PAK1/CHUK/PIK3R3/MAPK13/PIK3R2/BCL3	2.86291845287131
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	43/1974	140/9376	1.45885077435229	SPP1/MEF2C/GNGT1/GNG10/RPS6/RYR2/CALM1/CALM2/GNG5/GNG2/GNAI2/GNG11/CALM3/KLF2/PLCB1/EGR1/ITPR1/MAP2K2/ITPR2/GNB2/CCND1/PDE3B/GNB4/CALML4/TFAM/GNG7/HRAS/PRKACB/RPS6KB2/PRKACA/KRAS/PIK3CG/PLCB2/ADCY7/PIK3R5/NRAS/PIK3R4/RYR1/APLNR/MYL3/AGTR1/NOTCH3/MEF2B	2.82473815804631
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	71/1974	253/9376	1.33293287039818	CD14/RPS27A/UBA52/PFN1/ARPC3/UBB/ARPC1B/RBX1/PLCB1/MYL12B/ARPC2/SEPTIN7/ARPC5/ITPR1/WASF2/ACTR2/CXCL8/ITPR2/PYCARD/VDAC1/MYL12A/CYTH4/BAX/CDC42/TNFRSF1A/UBE2V1/SEPTIN2/SEPTIN11/ELMO1/CASP1/CAPNS1/TIFA/UBE2N/HCLS1/ATM/PLCD3/ARPC4/CYCS/RIPK1/JUN/RBCK1/ARPC1A/RRAGA/NLRP3/TRADD/ARPC5L/RPS6KB2/CAPN1/TLR4/ARHGEF2/PIK3CD/TNF/MAPK10/PLCB2/SHARPIN/TECPR1/CYTH2/IKBKG/TP53/PIK3R4/RIPK2/CHUK/PFN2/PIK3R3/PPID/U2AF1L4/MAPK13/PIK3R2/U2AF1/ELMO2/TRAF2	2.77225241341983
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	13/1974	30/9376	2.05822357311719	FOLR2/ABCC5/MTHFR/ABCC3/TNF/GART/SHMT2/GGH/IKBKG/TYMS/ABCG2/CHUK/SLC46A1	2.99784961306312
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	59/1974	205/9376	1.36700027182643	HLA-C/CCND2/CDK6/YWHAB/GTF2A2/LYN/RB1/BAX/RANBP1/CDC42/DLG1/HDAC9/GRB2/UBR4/SYK/CCND1/RBPJ/SP100/PMAIP1/HDAC8/JUN/GTF2B/REL/CDKN2A/VDAC3/CREB1/YWHAH/BAD/RBL2/HRAS/CDKN1B/PRKACB/TRADD/HDAC2/HDAC3/IRF9/SCIN/JAK3/CDK4/EGR2/HDAC1/PRKACA/KRAS/PIK3CD/SKP2/MRPS18B/NRAS/IKBKG/TP53/VAC14/DNAJA3/PIK3R3/PIK3R2/GTF2H3/TRAF3/CCNE1/TRAF2/CDK1/BAK1	2.74359271940968
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	42/1974	137/9376	1.45612672775276	CTSC/TUBA1B/CTSZ/ITPR1/MAP2K2/ITPR2/BAX/TNFRSF1A/PMAIP1/ATM/CYCS/RIPK1/JUN/TUBA1A/PARP1/TNFRSF10B/BAD/HRAS/BID/TRADD/BCL2A1/CTSO/CAPN1/KRAS/PIK3CD/TNF/MAPK10/NRAS/IKBKG/TP53/CHUK/CASP2/PIK3R3/PIK3R2/APAF1/HTRA2/AIFM1/CASP10/SEPTIN4/ENDOG/TRAF2/BAK1	2.77726929973943
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	18/1974	47/9376	1.81905193041454	LDHB/GLO1/AKR1A1/ADH5/GRHPR/ALDH9A1/MDH1/PDHB/MDH2/DLD/ACACB/ME2/ME1/HAGH/ALDH7A1/FH/ACAT2/DLAT	2.90688260230675
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	7/1974	12/9376	2.77068557919622	GGCX/COQ2/COQ4/COQ5/NQO1/COQ6/COQ7	3.16946560242857
Human Diseases	Cancer: specific types	hsa05214	Glioma	26/1974	76/9376	1.62491334719778	CALM1/CALM2/CDK6/CALM3/MAP2K2/IGF1/RB1/BAX/GRB2/CCND1/PRKCB/CDKN2A/SHC1/CALML4/HRAS/CDK4/KRAS/PIK3CD/E2F3/NRAS/DDB2/TP53/PIK3R3/PIK3R2/TGFA/BAK1	2.82468350918135
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	12/1974	27/9376	2.11099853653045	ELOVL2/SCP2/HACD4/HSD17B4/HSD17B12/FADS1/HACD3/ACAA1/SCD5/ELOVL1/FADS2/ACOX3	2.98536516591351
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	43/1974	142/9376	1.43830358034733	TYROBP/CYBA/FCGR3A/CSF1R/NCF4/ITPR1/ITPR2/FCGR2A/TNFRSF1A/GRB2/FCGR1A/SYK/SPI1/FHL2/CSF1/PPP3R1/JUNB/LILRB5/JUN/LCP2/CREB1/TMEM64/SIRPA/STAT2/NCF2/IFNAR2/TNFRSF11A/IRF9/TEC1/PIK3CD/TNF/MAPK10/MAP2K6/IKBKG/CHUK/PIK3R3/MAPK13/PIK3R2/LILRB2/LILRB1/BTK/TRAF2/BLNK	2.71774638874151
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	43/1974	142/9376	1.43830358034733	CCL2/CYBA/MEF2C/SUMO2/CALM1/CALM2/GSTP1/CALM3/KLF2/BMP4/MMP2/VCAM1/MGST3/SUMO1/ACVR2A/MGST2/TNFRSF1A/GSTO1/HSP90B1/JUN/BMPR1A/TXN2/PECAM1/SUMO3/ICAM1/CALML4/NCF2/ARHGEF2/CDH5/PIK3CD/TNF/MAPK7/MAPK10/MAP2K6/IKBKG/TP53/RAC2/GSTA4/CHUK/PIK3R3/MAPK13/PIK3R2/NQO1	2.71774638874151
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	26/1974	77/9376	1.60381057645495	CDK6/RB1/PLD1/BAX/CDC42/CCND1/CDKN2A/BAD/RPS6KB2/CDK4/RALB/KRAS/PIK3CD/MAPK10/E2F3/IKBKG/DDB2/TP53/RAC2/CHUK/TGFB3/PIK3R3/PIK3R2/PLD2/TGFA/BAK1	2.74734137480778
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	18/1974	48/9376	1.78115501519757	HADHB/ALDH9A1/HADHA/HMGCLL1/ECHS1/HSD17B10/DLD/BCAT1/HIBCH/ACADM/ACAA1/ACADS/IVD/ALDH7A1/ACAT2/PCCB/MCEE/HADH	2.80187171705636
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	21/1974	59/9376	1.69058781103498	HPGDS/GPX4/GSTP1/LAP3/MGST3/MGST2/GPX7/GSTO1/GCLM/ODC1/SMS/GSTK1/IDH2/GPX8/SRM/TXNDC12/GGCT/LANCL1/GSTA4/G6PD/GSS	2.74784061735069
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	34/1974	108/9376	1.4952906300424	SUMO2/SAP18/RAN/SUMO1/SRRM1/MAGOH/UPF3A/PNN/RBM8A/UBE2I/EIF4A3/XPO1/SUMO3/RANBP17/NMD3/SEC13/ALYREF/XPO4/NUP42/TMEM33/UPF3B/MAGOHB/PYM1/NUP62/NCBP2/XPO7/RAE1/IPO13/NUP107/KPNA2/IPO8/THOC3/NUP37/GLE1	2.67339818707411
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	34/1974	109/9376	1.48157236738146	SPP1/CD14/CCL3/CCL4/CCL4L2/CCL3L1/LY96/MAP2K2/CD86/CXCL8/TLR1/RIPK1/JUN/STAT2/IFNAR2/IRF9/TLR4/PIK3CD/TNF/TLR7/MAPK10/IRAK1/MAP2K6/IKBKG/IRAK4/CHUK/PIK3R3/MAPK13/PIK3R2/TRAF3/IRF5/TICAM2/CD40/TIRAP	2.61149920881154
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	50/1974	173/9376	1.37275916392876	CCL2/SLC25A6/CDK6/SLC25A5/MAP2K2/CXCL8/PYCARD/VDAC1/BAX/TNFRSF1A/CASP1/RAB11A/XPO1/CYCS/PRKCB/PABPN1/ICAM1/TNFRSF10B/ADAR/NLRP3/HLA-DPA1/BID/STAT2/TRADD/PML/FDPS/IFNAR2/IRF9/TLR4/CDK4/PIK3CD/TNF/TLR7/RNASEL/HLA-DQA2/RAE1/IKBKG/SLC25A4/IRAK4/HLA-DMA/CHUK/KPNA2/PIK3R3/PIK3R2/APAF1/TRIM25/TRAF3/CPSF4/IFIH1/BAK1	2.55547326336938
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	16/1974	42/9376	1.8094273170261	INMT/ALDH9A1/HADHA/ECHS1/HAAO/DLD/CYP1A2/CAT/AFMID/KYAT3/KYNU/IDO2/ALDH7A1/ACAT2/IDO1/HADH	2.71489649003898
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	42/1974	142/9376	1.40485465987414	RPS27A/UBA52/ELOB/WWP1/UBB/RBX1/ANAPC11/RNF7/ELOC/UBE2M/UBE2I/ANAPC16/UBE2L3/UBE2E3/UBE2N/PIAS2/ANAPC10/UBE2J1/UBE2A/UBA6/CDC34/STUB1/UBE2J2/MAP3K1/PML/ANAPC13/PRKN/TRIM37/PRPF19/CDC26/UBE2S/SKP2/RHOBTB1/UBE2L6/UBE3B/DDB2/ERCC8/CDC23/ANAPC15/FBXO4/UBA7/UBE2C	2.51034292023394
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	23/1974	69/9376	1.58324890239784	FCER1G/LYN/MAP2K2/GRB2/ALOX5AP/SYK/LCP2/VAV1/HRAS/INPP5D/KRAS/PIK3CD/TNF/ALOX5/MAPK10/VAV3/MAP2K6/NRAS/RAC2/PIK3R3/MAPK13/PIK3R2/BTK	2.51106694168745
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	10/1974	23/9376	2.06510726399718	SSBP1/RPA3/MLH3/PCNA/MSH3/POLD2/PMS2/RFC3/RFC4/MSH2	2.64098825241775
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	29/1974	93/9376	1.48110381192056	CALM1/CALM2/CALM3/MMP2/PLCB1/EGR1/ITPR1/MAP2K2/ITPR2/PLD1/GNAS/CDC42/GRB2/PRKCB/JUN/CALML4/HRAS/PRKACB/MAP3K1/PRKACA/KRAS/MAPK7/MAPK10/PLCB2/ADCY7/MAP2K6/NRAS/MAPK13/PLD2	2.40780198965318
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	29/1974	93/9376	1.48110381192056	LAMA2/CDK6/RARB/LAMA4/RB1/BAX/CCND1/MAX/CYCS/CKS2/CDKN1B/LAMA5/CDK4/PIK3CD/CKS1B/SKP2/E2F3/IKBKG/DDB2/TP53/COL4A4/CHUK/PIK3R3/PIK3R2/APAF1/TRAF3/CCNE1/TRAF2/BAK1	2.40780198965318
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	16/1974	44/9376	1.72718062079764	HMGB1/MPG/PARP1/TDG/APEX1/POLE4/MBD4/PCNA/PARG/POLD2/OGG1/RFC3/RFC4/PNKP/SMUG1/POLL	2.49669758789583
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	48/1974	170/9376	1.34110495261935	WNT2/HGF/CDK6/GSTP1/MGST3/FZD4/MAP2K2/RB1/MGST2/BAX/GRB2/GSTO1/CCND1/SMARCE1/SMARCB1/PRKCB/CDKN2A/SHC1/BRD7/BAD/APC/DVL3/HRAS/LRP6/SMARCA4/AXIN2/RPS6KB2/WNT5B/CDK4/SMARCD1/KRAS/PIK3CD/E2F3/NRAS/DDB2/TP53/GSTA4/TGFB3/PIK3R3/ACTL6A/PIK3R2/TCF7/NQO1/TGFA/WNT10A/WNT11/BAK1/SMARCD3	2.31772375780446
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	15/1974	41/9376	1.73771220994885	MMP2/MAP2K2/CXCL8/RB1/CCND1/CDKN2A/HRAS/MMP1/CDK4/KRAS/E2F3/NRAS/TP53/RASSF1/FGFR3	2.44459213840313
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	38/1974	130/9376	1.3883874990258	COL3A1/GNGT1/COL1A2/GNG10/COL1A1/GNG5/GNG2/GNAI2/GNG11/MMP2/PLCB1/MAP2K2/GNB2/GNAS/GRB2/JUN/CREB1/SHC1/ARRB2/VEGFB/GNB4/GNG7/HRAS/PRKACB/MMP1/GNA15/PRKACA/KRAS/PIK3CD/ARRB1/MAPK10/PLCB2/ADCY7/NRAS/COL4A4/PIK3R3/MAPK13/PIK3R2	2.30273862928601
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	19/1974	56/9376	1.61152120422637	DAD1/TMEM258/OSTC/KRTCAP2/RPN2/DDOST/MAN1C1/ST6GAL1/TUSC3/ALG5/DPM3/DPM2/MAN1B1/ALG8/MGAT3/MGAT2/DOLK/MAN2A2/SRD5A3	2.37018502512606
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	19/1974	56/9376	1.61152120422637	CCND2/DISP1/SCUBE2/CCND1/GLI3/ARRB2/GRK2/GRK3/PRKACB/PTCH1/CSNK1G2/PRKACA/GLI2/ARRB1/SUFU/CDON/KIF7/KIF3A/IQCE	2.37018502512606
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	24/1974	75/9376	1.51991894630193	GSTP1/MGST3/MGST2/BAX/GSTO1/PMAIP1/ATM/CYCS/CDKN2A/BAD/XPA/BID/PIK3CD/MSH3/TP53/GSTA4/TOP2A/PIK3R3/PIK3R2/APAF1/ATP7A/MSH2/ATP7B/BAK1	2.33445832513173
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	28/1974	91/9376	1.46146052529031	CD81/LYN/MAP2K2/GRB2/SYK/PPP3R1/PIK3AP1/PRKCB/LILRB5/JUN/VAV1/NFATC3/HRAS/PTPN6/INPP5D/KRAS/PIK3CD/VAV3/NRAS/IKBKG/RAC2/CHUK/PIK3R3/PIK3R2/LILRB2/LILRB1/BTK/BLNK	2.28427806914646
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	30/1974	99/9376	1.43931718399804	MMP2/MAP2K2/IGF1/RB1/GNAS/BAX/GRB2/CCND1/JUN/CDKN2A/SHC1/BAD/HRAS/CDKN1B/PRKACB/RPS6KB2/CDK4/PRKACA/KRAS/PIK3CD/MAPK10/ADCY7/E2F3/NRAS/TP53/PIK3R3/CDKN2C/MAPK13/PIK3R2/NOTCH3	2.26922041544915
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	9/1974	21/9376	2.03560573165436	CSGALNACT2/CHSY3/DSEL/CSGALNACT1/B4GALT7/B3GAT3/B3GALT6/XYLT2/CHST12	2.453391570956
Human Diseases	Infectious disease: viral	hsa05162	Measles	39/1974	136/9376	1.36205971750402	CCND2/RACK1/CDK6/EIF3H/BAX/CSNK2B/CD28/CCND1/RAB9A/CD209/CYCS/JUN/BAD/ADAR/CDKN1B/BID/STAT2/TRADD/IFNAR2/IRF9/JAK3/TLR4/CDK4/PIK3CD/TLR7/MAPK10/IRAK1/IKBKG/TP53/IRAK4/CHUK/PIK3R3/PIK3R2/APAF1/IL2RA/TRAF3/CCNE1/IFIH1/BAK1	2.19633381861018
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	11/1974	28/9376	1.86597192068317	ELOVL2/HADHB/HADHA/ECHS1/HACD4/PPT1/HSD17B12/HACD3/ELOVL1/HADH/MECR	2.36978063336717
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	17/1974	50/9376	1.6149138804458	CCL2/HGF/CR1/CD81/CD36/GYPC/VCAM1/CXCL8/LRP1/HBB/PECAM1/ICAM1/TLR4/TNF/TGFB3/ACKR1/CD40	2.25131500057821
Human Diseases	Cancer: specific types	hsa05218	Melanoma	23/1974	73/9376	1.49649553788289	HGF/CDK6/FGF7/PDGFC/MAP2K2/IGF1/RB1/BAX/FGF10/CCND1/CDKN2A/BAD/HRAS/CDK4/KRAS/PIK3CD/E2F3/NRAS/DDB2/TP53/PIK3R3/PIK3R2/BAK1	2.19912512969183
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	15/1974	43/9376	1.6568883862303	ADH5/HADHB/ALDH9A1/HADHA/ECHS1/ACADVL/CPT1A/ACADM/ACAA1/ACADS/CPT2/ALDH7A1/ACAT2/ACOX3/HADH	2.22946085036807
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	45/1974	163/9376	1.31127976578962	YWHAB/MAP2K2/CXCL8/RB1/BAX/GRB2/CYCS/PRKCB/JUN/VDAC3/CREB1/NFATC3/BAD/HRAS/MAP3K1/BID/STAT2/PCNA/JAK3/TLR4/EGR2/KRAS/PIK3CD/TNF/MAPK10/IRAK1/E2F3/MAP2K6/NRAS/IKBKG/DDB2/TP53/IRAK4/CHUK/TGFB3/PIK3R3/MAPK13/PIK3R2/APAF1/TRAF3/TICAM2/CASP10/CCNE1/IFIH1/TIRAP	2.07027877490173
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	13/1974	36/9376	1.71518631093099	SSBP1/RNASEH2C/RPA3/POLE4/RNASEH2B/PCNA/RNASEH1/POLD2/POLA1/MCM3/MCM5/RFC3/RFC4	2.22014672725097
Organismal Systems	Immune system	hsa04611	Platelet activation	36/1974	126/9376	1.35707048776958	FCER1G/COL3A1/COL1A2/COL1A1/VAMP8/GNAI2/PLCB1/MYL12B/GUCY1A2/ITPR1/LYN/ITPR2/PPP1CA/FCGR2A/MYL12A/GNAS/GUCY1A1/SYK/TBXAS1/PRKG1/LCP2/PRKACB/FERMT3/PPP1CC/PRKACA/PIK3CD/PIK3CG/PLCB2/ADCY7/PIK3R5/ORAI1/PIK3R3/MAPK13/PIK3R2/PTGS1/BTK	2.08378561184845
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	49/1974	180/9376	1.2929866036249	CCL2/B2M/HLA-C/BST2/SRSF9/CALR/PDIA3/PPP1CA/BAX/TNFRSF1A/SYK/POU2F2/SRSF1/SP100/CYCS/BAD/ALYREF/HLA-DPA1/BID/STAT2/TRADD/PML/IFNAR2/PPP1CC/IRF9/TAPBP/PIK3CD/TNF/RNASEL/IRAK1/EIF2B3/HLA-DQA2/TSC2/IKBKG/TP53/IRAK4/HLA-DMA/CHUK/EIF2B2/PIK3R3/PIK3R2/APAF1/SRSF8/TRAF3/TNFRSF14/TAP2/IFIH1/TRAF2/BAK1	2.04960044447458
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	24/1974	78/9376	1.46146052529031	LSM3/LSM7/LSM8/C1D/LSM6/LSM4/LSM5/TENT4B/LSM2/LSM1/EXOSC6/PFKL/EXOSC8/NUDT16/EXOSC1/EXOSC3/EXOSC9/DCPS/EDC3/PNPT1/PABPC4L/EXOSC5/EXOSC4/DIS3L	2.11335160744421
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	17/1974	51/9376	1.58324890239784	ATP6V1G1/SEC61B/ATP6V1F/ATP6V0B/SEC61G/KDELR2/ATP6V0E1/GNAS/ATP6V1D/SEC61A1/ATP6V1A/PRKACB/KCNQ1/ATP6V1H/PRKACA/TCIRG1/CFTR	2.15674733451672
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	36/1974	128/9376	1.33586626139818	NME2/ENPP1/PDE4D/APRT/GUK1/GUCY1A2/NME4/GUCY1A1/NT5C/ITPA/HDDC2/DGUOK/NME3/IMPDH2/PDE3B/PAPSS2/NUDT2/GMPR/NUDT16/NUDT5/AK1/GART/ADCY7/NME1/DCK/GMPR2/LACC1/PDE9A/ADA2/PDE5A/AMPD2/IMPDH1/HDDC3/PRPS1/NME6/NTPCR	1.97575061749347
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	11/1974	30/9376	1.74157379263762	PIGP/GPAA1/PIGF/PIGX/PIGC/DPM2/PIGH/PIGS/PGAP3/PIGU/PIGM	2.10081004032808
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	53/1974	200/9376	1.25868287740628	TUBA1B/ARPC3/ARPC1B/RPS3/BRK1/TUBB/ARPC2/ARPC5/WASF2/ACTR2/CXCL8/PYCARD/FCGR2A/CYTH4/BAX/CDC42/TNFRSF1A/MYH10/CASP1/NCKAP1L/HCLS1/CYFIP1/MYO1B/ARPC4/CYCS/RIPK1/JUN/TUBA1A/ARPC1A/NCK2/MYO5A/TNFRSF10B/NLRP3/TRADD/PTPN6/ARPC5L/TLR4/ARHGEF2/CLDN23/TNF/MAPK10/MYO1F/IRAK1/LPAR5/CYTH2/IKBKG/PAK1/IRAK4/CHUK/MAPK13/TRAF2/TIRAP/BAK1	1.90959228088588
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	43/1974	158/9376	1.29265258486912	WNT2/RPS6/ATP6V1G1/ATP6V1F/LAMTOR4/LAMTOR1/LAMTOR5/FZD4/MAP2K2/IGF1/TNFRSF1A/GRB2/ATP6V1D/LAMTOR2/EIF4E2/PRKCB/PRR5/RRAGA/ATP6V1A/SEC13/DVL3/HRAS/LRP6/ATP6V1H/RPS6KB2/WNT5B/KRAS/PIK3CD/SKP2/NPRL3/TNF/EIF4E/TSC2/NRAS/MIOS/TELO2/CHUK/MLST8/PIK3R3/PIK3R2/RPS6KA1/WNT10A/WNT11	1.91578702662085
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	13/1974	38/9376	1.62491334719778	PMM1/GNPDA1/GALK2/GPI/UXS1/AMDHD2/RENBP/GNPDA2/FPGT/GCK/GMPPA/MPI/GALK1	1.99328471334687
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	42/1974	155/9376	1.28702814001373	CD14/HLA-C/CYBA/FCGR3A/CYBB/TUBA1B/ATP6V1G1/SEC61B/ATP6V1F/C1R/CD36/ATP6V0B/SEC61G/CALR/TUBB/NCF4/COLEC12/RAB5C/ATP6V0E1/FCGR2A/FCGR1A/ATP6V1D/M6PR/SEC61A1/CORO1A/CLEC7A/MRC2/CD209/MSR1/TUBA1A/ATP6V1A/HLA-DPA1/NCF2/ITGB5/ITGAM/DYNC1LI1/ATP6V1H/TLR4/HLA-DQA2/TCIRG1/HLA-DMA/TAP2	1.86074125575056
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	26/1974	89/9376	1.38756645378687	TUBA1B/GNAI2/PLCB1/TUBB/GUCY1A2/PDGFC/ITPR1/MAP2K2/ITPR2/GNAS/GRB2/GUCY1A1/PRKCB/PRKG1/TUBA1A/HRAS/PRKACB/PRKACA/KRAS/MAPK7/PLCB2/ADCY7/NRAS/ADRB1/HTR2C/CDK1	1.89709086035598
Organismal Systems	Endocrine system	hsa04924	Renin secretion	21/1974	69/9376	1.44557508479803	CALM1/CALM2/GNAI2/CALM3/PLCB1/GUCY1A2/ITPR1/ITPR2/GNAS/GUCY1A1/PPP3R1/CREB1/PDE3B/CALML4/PRKACB/PRKACA/PTGER4/PLCB2/ORAI1/ADRB1/AGTR1	1.91833857016454
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	14/1974	42/9376	1.58324890239784	FTL/SLC40A1/CYBB/GPX4/NCOA4/ATG7/FTH1/VDAC2/GCLM/SAT2/VDAC3/SLC7A11/TP53/GSS	1.95627249616029
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	48/1974	181/9376	1.2596013367143	CD14/FCER1G/FCGR3A/CALM1/CALM2/CALM3/CR1/ATP6V0B/LSP1/RAB5C/FCGR2A/BAX/TNFRSF1A/FCGR1A/SYK/PPP3R1/CORO1A/CLEC7A/MRC2/CD209/TLR1/CYCS/CREB1/BAD/CALML4/HLA-DPA1/RFXANK/BID/TRADD/IL10RA/ITGAM/ATP6V1H/TLR4/TNF/NFYC/MAPK10/IRAK1/HLA-DQA2/CEBPG/TCIRG1/RIPK2/IRAK4/HLA-DMA/TGFB3/MAPK13/APAF1/CASP10/TIRAP	1.82118899368995
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	23/1974	78/9376	1.40056633673655	CLTA/ARPC3/CLTC/ARPC1B/ARPC2/ARPC5/WASF2/ACTR2/CDC42/SEPTIN2/SEPTIN11/ELMO1/HCLS1/ARPC4/RHOG/ARPC1A/SHC1/ARPC5L/PIK3CD/MAD2L2/PIK3R3/PIK3R2/ELMO2	1.83447438130846
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	23/1974	78/9376	1.40056633673655	CYBA/FCGR3A/CYBB/CR1/NCF4/FCGR2A/FCGR1A/PRKCB/JUN/HLA-DPA1/NCF2/PTPN6/ITGAM/TLR4/TNF/IRAK1/HLA-DQA2/IRAK4/HLA-DMA/TGFB3/MAPK13/ITGA4/MARCKSL1	1.83447438130846
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	21/1974	70/9376	1.42492401215805	ELOB/HGF/RBX1/MAP2K2/ELOC/HIF1A/CDC42/GRB2/JUN/BAD/HRAS/KRAS/PIK3CD/SLC2A1/NRAS/PAK1/FH/TGFB3/PIK3R3/PIK3R2/TGFA	1.84273736193391
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	46/1974	174/9376	1.2556801639707	SEC61B/RBX1/DAD1/TMEM258/OSTC/KRTCAP2/SEC61G/SSR4/CALR/SSR2/TRAM1/PDIA3/UBXN1/PDIA6/VCP/RPN2/BAX/HSPA5/ERP29/LMAN2/DDOST/MAN1C1/HSP90B1/RAD23A/SEC61A1/BAG1/DNAJB11/DERL2/ERLEC1/TUSC3/UBE2J1/SEC13/STUB1/UBE2J2/SSR1/PRKN/UFD1/CAPN1/MAN1B1/MAPK10/SEC23B/EDEM1/YOD1/PLAA/TRAF2/BAK1	1.75798521323815
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	53/1974	204/9376	1.23400282098655	LUM/WNT2/DCN/CD63/COL1A2/HGF/RPS6/COL1A1/VTN/MMP2/ITPR1/FZD4/MAP2K2/HIF1A/IGF1/ITPR2/TWIST1/PPP1CA/CDC42/GRB2/CCND1/HCLS1/PRKCB/VAV1/ANK2/TWIST2/HRAS/PRKACB/PLAUR/ANK3/ITGB5/PTPN6/PLAU/PPP1CC/PTCH1/RPS6KB2/WNT5B/TLR4/PRKACA/KRAS/PIK3CD/TNF/DROSHA/VAV3/NRAS/TP53/NUDT16L1/PAK1/PIK3R3/MAPK13/PIK3R2/WNT10A/WNT11	1.74497345879157
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	29/1974	103/9376	1.33730732532633	CD14/COL3A1/LAMA2/COL1A2/COL1A1/PLCB1/PRDX1/SERPINB9/LAMA4/CXCL8/RAB5C/GNAS/SERPINB6/GNA14/PRKCB/PRKACB/LAMA5/ITGAM/TLR4/GNA15/PRKACA/PIK3CD/TNF/PLCB2/COL4A4/ARG2/TGFB3/PIK3R3/PIK3R2	1.77753813729787
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	27/1974	95/9376	1.34992801151816	CCL3/CCL2/CCL3L1/ATP6V1G1/ATP6V1F/ANGPT1/ATP6V0B/CD86/CXCL8/ATP6V0E1/ATP6V1D/CD28/CSF1/JUN/TNFSF13B/ICAM1/ATP6V1A/HLA-DPA1/MMP1/TNFRSF11A/ATP6V1H/TLR4/TNF/HLA-DQA2/TCIRG1/HLA-DMA/TGFB3	1.77022225839083
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	24/1974	83/9376	1.37342073461017	PRDX1/PRDX5/SCP2/HMGCLL1/PEX2/GSTK1/ECH1/IDH2/CAT/MPV17/PXMP2/HSD17B4/PMVK/PEX16/AGPS/ACAA1/PEX11B/PHYH/NUDT19/PEX3/CRAT/ACOX3/PEX10/PEX11G	1.76459148240044
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	18/1974	59/9376	1.44907526660141	NME2/ENPP1/DUT/NME4/NT5C/HDDC2/NME3/NUDT2/NME1/DCK/TK2/TYMS/UMPS/DTYMK/UCK1/CMPK2/DCTPP1/NME6	1.78686509969757
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	21/1974	71/9376	1.40485465987414	LDHB/MAP2K2/HIF1A/PDHB/IDH2/PGAM1/HRAS/PFKL/KRAS/PIK3CD/SLC2A1/FGFR2/TIGAR/NRAS/TP53/G6PD/PIK3R3/PIK3R2/FGFR3/GCK/SCO2	1.76829533002397
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	19/1974	63/9376	1.43246329264566	WNT2/BMP4/FZD4/BAX/GLI3/APC/DVL3/AXIN2/PTCH1/WNT5B/GLI2/DDB2/TP53/SUFU/TCF7/KIF7/WNT10A/WNT11/BAK1	1.77852263113655
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	20/1974	67/9376	1.41783483796821	CALM1/CALM2/CALM3/PLCB1/ITPR1/MAP2K2/ITPR2/PPP1CA/PPP3R1/PRKCB/CALML4/HRAS/PRKACB/PPP1CC/PRKACA/KRAS/PLCB2/GRIN2C/NRAS/RPS6KA1	1.77245495007171
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	82/1974	333/9376	1.16960729726687	SPP1/HLA-C/LAMA2/WNT2/CCND2/COL1A2/COL1A1/ATP6V1G1/ATP6V1F/CDK6/ATP6V0B/VTN/COL6A1/LAMA4/FZD4/MAP2K2/MAGI1/ATP6V0E1/RB1/GNAS/BAX/CDC42/TNFRSF1A/DLG1/GRB2/UBR4/ATP6V1D/CCND1/RBPJ/ATM/COL6A2/CREB1/ATP6V1A/TNXB/BAD/RBL2/APC/DVL3/HRAS/CDKN1B/PRKACB/STAT2/LAMA5/TRADD/HDAC2/ITGB5/IFNAR2/AXIN2/ATP6V1H/IRF9/RPS6KB2/WNT5B/CDK4/ATR/HDAC1/PRKACA/KRAS/PIK3CD/PTGER4/IRF1/TNF/DLG3/TADA3/ISG15/TSC2/NRAS/IKBKG/TCIRG1/TP53/COL4A4/CHUK/PIK3R3/PIK3R2/TCF7/TUBG1/TRAF3/ITGA4/NOTCH3/CCNE1/WNT10A/WNT11/BAK1	1.62740279273516
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	23/1974	80/9376	1.36555217831814	HGF/RPS6/PDGFC/MAP2K2/IGF1/GAS6/BAX/GRB2/EIF4E2/PRKCB/SHC1/BAD/HRAS/RPS6KB2/KRAS/PIK3CD/FGFR2/EIF4E/NRAS/PIK3R3/PIK3R2/FGFR3/TGFA	1.69562957998764
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	33/1974	122/9376	1.28476755194579	SLC16A10/BMP4/PLCB1/ATP1B3/ATP1B1/MAP2K2/HIF1A/CCND1/PLCD3/PRKCB/BAD/HRAS/PFKL/TBC1D4/PRKACB/HDAC2/HDAC3/THRA/HDAC1/PRKACA/KRAS/PIK3CD/PLCB2/SLC2A1/TSC2/MED12/NRAS/PFKFB2/MED16/TP53/PIK3R3/PIK3R2/NOTCH3	1.63489679145815
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	12/1974	37/9376	1.54045839152222	TPM3/NCOA4/MAP2K2/BAX/CCND1/HRAS/KRAS/NRAS/DDB2/TP53/TCF7/BAK1	1.7009737469225
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	29/1974	106/9376	1.29945900479823	FOLR2/GSTP1/PDGFC/MAP2K2/IGF1/RB1/GRB2/ETV5/CCND1/HSP90B1/CREB1/BAD/HRAS/CDKN1B/PLAU/KRAS/PIK3CD/FGFR2/E2F3/NRAS/IKBKG/TP53/CHUK/PIK3R3/PIK3R2/TCF7/SLC46A1/CCNE1/TGFA	1.60116140991735
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	48/1974	187/9376	1.21918632056304	CCL2/CYBA/CYBB/GABARAP/IFI16/CARD16/GABARAPL2/PLCB1/ITPR1/CXCL8/ITPR2/ANTXR1/PYCARD/VDAC1/VDAC2/CASP1/RIPK1/JUN/RBCK1/VDAC3/TXN2/TRIP6/GPSM3/GSDMD/NLRP3/STAT2/SUGT1/PKN1/IFNAR2/IRF9/TLR4/TNF/RNASEL/MAPK10/PLCB2/TRPM2/GBP1/SHARPIN/IKBKG/CARD8/NLRP1/RIPK2/IRAK4/CHUK/MAPK13/TRAF3/TRPV2/TRAF2	1.56345287628534
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	25/1974	90/9376	1.31937408533153	EML4/MAP2K2/HIF1A/CSNK2B/CD28/CD4/PPP3R1/JUN/NFATC3/HRAS/PTPN6/RPS6KB2/TLR4/KRAS/PIK3CD/BATF/MAP2K6/NRAS/IKBKG/CHUK/PIK3R3/MAPK13/PIK3R2/TICAM2/TIRAP	1.57214015610031
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	28/1974	103/9376	1.29119327962542	CCL3/CCL2/C1QA/C1QB/C1QC/CCL3L1/GNAI2/PLCB1/CALR/CXCL8/GNAS/TNFRSF1A/GNA14/JUN/TLR4/GNA15/PIK3CD/TNF/MAPK10/PLCB2/IRAK1/IKBKG/IRAK4/CHUK/TGFB3/PIK3R3/MAPK13/PIK3R2	1.53452688689245
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	27/1974	99/9376	1.29538546559823	CALM1/CALM2/CALM3/PLCB1/ITPR1/IGF1/ITPR2/PPP1CA/GNAS/HRH1/PRKCB/CALML4/PRKACB/PPP1CC/PRKACA/PIK3CD/PTGER4/MAPK10/PLCB2/ADCY7/MAP2K6/PIK3R3/MAPK13/PIK3R2/TRPA1/HTR2C/TRPV2	1.52576487644393
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	11/1974	34/9376	1.53668275820967	POLR2L/POLR2K/POLR2E/POLR2J/POLR2F/POLR2I/POLR2G/POLR1D/POLR3GL/POLR2C/POLR3A	1.61890678089836
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	15/1974	50/9376	1.42492401215805	LAP3/ALDH9A1/ODC1/SAT2/SMS/CNDP2/SRM/GATM/PYCR2/ALDH7A1/ARG2/GAMT/GOT1/L3HYPDH/GOT2	1.55572647341083
NA	NA	hsa04981	Folate transport and metabolism	10/1974	31/9376	1.5321763571592	FOLR2/SLCO2B1/ABCC5/MTHFR/MTHFS/ABCC3/SHMT2/TYMS/ABCG2/SLC46A1	1.53260925008447
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	17/1974	59/9376	1.36857108512356	MAP2K2/BAX/GRB2/CCND1/BAD/APC/HRAS/AXIN2/KRAS/PIK3CD/NRAS/DDB2/TP53/PIK3R3/PIK3R2/TCF7/BAK1	1.46653992714653
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	28/1974	105/9376	1.26659912191827	RPS27A/UBA52/TOMM7/UBB/GABARAP/GABARAPL2/TOMM20/FIS1/HIF1A/RAB5C/VCP/CSNK2B/JUN/MTX2/HRAS/PRKN/KRAS/MAPK10/FUNDC1/NRAS/TP53/MON1B/MTX3/CCZ1/SAMM50/USP30/TRAF2/TFEB	1.41864831203941
Organismal Systems	Nervous system	hsa04730	Long-term depression	17/1974	60/9376	1.34576156703816	GNAI2/PLCB1/GUCY1A2/ITPR1/LYN/MAP2K2/IGF1/ITPR2/GNAS/GUCY1A1/PRKCB/PRKG1/HRAS/KRAS/PLCB2/NRAS/RYR1	1.38746576224397
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	39/1974	154/9376	1.20285793234121	MEF2C/RYR2/CALM1/CALM2/GNAI2/CALM3/PLCB1/GUCY1A2/MYL6/ITPR1/MAP2K2/ITPR2/PPP1CA/GNAS/GUCY1A1/CCND1/PPP3R1/PRKCB/JUN/NFATC3/CALML4/HRAS/PRKACB/CACNB4/CACNA2D4/PPP1CC/PRKACA/KCNJ5/KRAS/PIK3CG/MAPK7/PLCB2/ADCY7/TRPM2/PIK3R5/NRAS/RYR1/KCNJ12/MYL6B	1.31076388834689
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	10/1974	32/9376	1.48429584599797	BAX/TNFRSF1A/PMAIP1/CYCS/BID/MAPK10/APAF1/HTRA2/SEPTIN4/BAK1	1.41711139497258
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	58/1974	238/9376	1.1575012983917	GNGT1/GNG10/HGF/CALM1/CALM2/GNG5/GNG2/GNG11/ANGPT1/CALM3/FGF7/CSF1R/PDGFC/MAP2K2/RAB5C/IGF1/GNB2/PLD1/CDC42/GRB2/FGF10/RGL1/CSF1/KITLG/BDNF/PRKCB/REL/SHC1/VEGFB/GNB4/BAD/CALML4/GNG7/HRAS/RASA3/PRKACB/PLAAT3/FGFR4/RALB/PRKACA/KRAS/PIK3CD/MAPK10/RGL2/FGFR2/NRAS/IKBKG/RAC2/PAK1/CHUK/PIK3R3/PIK3R2/SYNGAP1/RASSF1/FGFR3/RASSF5/PLD2/TGFA	1.27095950088628
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	31/1974	120/9376	1.22701789935832	CALM1/CALM2/CALM3/BEX3/MAP2K2/BAX/CDC42/GRB2/ARHGDIB/BDNF/JUN/SHC1/BAD/CALML4/HRAS/SH2B3/MAP3K1/KRAS/PIK3CD/MAPK7/MAPK10/IRAK1/NRAS/TP53/RIPK2/IRAK4/PIK3R3/MAPK13/PIK3R2/RPS6KA1/SH2B1	1.2924796764842
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	52/1974	212/9376	1.16503221119841	PFN1/HGF/CALM1/CALM2/GNAI2/ANGPT1/CALM3/FGF7/PLCB1/CSF1R/PDGFC/FYB1/ID1/MAP2K2/IGF1/MAGI1/GNAS/CDC42/MAGI3/FGF10/CSF1/EVL/KITLG/SIPA1L2/PRKCB/LCP2/VAV1/VEGFB/CALML4/DOCK4/HRAS/FPR1/FGFR4/ITGAM/RALB/KRAS/PIK3CD/PLCB2/ADCY7/FGFR2/VAV3/LPAR5/SIPA1/MAP2K6/NRAS/RAC2/PFN2/PIK3R3/MAPK13/PIK3R2/FGFR3/RASSF5	1.25510130412229
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	30/1974	116/9376	1.22838276910177	GNGT1/GNG10/GNG5/GNG2/GNAI2/GNG11/PLCB1/ITPR1/ITPR2/GNB2/PLD1/GNAS/PPP3R1/PRKCB/DLGAP1/GNB4/GRK2/GRK3/GNG7/PRKACB/GRIA4/PRKACA/PLCB2/ADCY7/HOMER3/GRIN2C/DLG4/SLC1A1/PLD2/SLC1A2	1.27811963779091
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	15/1974	53/9376	1.34426793599816	CLTA/AP2S1/CLTC/PLCB1/ATP1B3/AP2M1/ATP1B1/ATP2B1/GNAS/RAB11A/PRKCB/PRKACB/PRKACA/PLCB2/KL	1.29790032290907
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	7/1974	21/9376	1.58324890239784	ENPP1/PPCS/BCAT1/PPCDC/PANK1/CSAD/COASY	1.38174007459991
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	19/1974	70/9376	1.2892169633811	HLA-C/LAMA2/EIF4G3/SGCE/CD86/CD28/CCND1/CYCS/ICAM1/SGCB/HLA-DPA1/SGCA/BID/SNTA1/DTNA/HLA-DQA2/RAC2/HLA-DMA/CD40	1.2542263766661
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	9/1974	29/9376	1.47405932292213	RASSF4/MOB1A/NF2/LATS1/FAT4/MOB1B/PAK1/LIMD1/RASSF1	1.32032316033522
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	10/1974	33/9376	1.43931718399804	PDHB/DLD/IDH2/IDH3G/BCAT1/CS/ACY1/DLAT/GOT1/GOT2	1.30549934611367
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/1974	10/9376	1.89989868287741	SELENBP1/PAPSS2/ETHE1/TST	1.47028393322471
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	39/1974	157/9376	1.17987338586336	C1QA/C1QB/C1QC/CD36/CALR/PROS1/MAP2K2/HIF1A/RAB5C/STAB1/LRP1/GAS6/ADAM9/ELMO1/CASP1/ODC1/RAB14/UQCRFS1/VPS8/CD47/CREB1/NFATC3/PECAM1/DNMT3A/SIRPA/VPS16/ITGB5/PTPN6/PTGER4/ALOX5/CPT1A/SLC2A1/HAVCR2/CX3CR1/EPOR/ARG2/VPS11/MAPK13/TGFBRAP1	1.17370647487653
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	19/1974	71/9376	1.27105897798136	ATP6V1G1/ATP6V1F/ATP6V0B/LYN/CXCL8/ATP6V0E1/CDC42/ATP6V1D/JUN/ATP6V1A/ATP6V1H/MAPK10/CSK/IKBKG/TCIRG1/PAK1/CHUK/MAPK13/GIT1	1.18391208606695
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	39/1974	158/9376	1.17240583278827	CCND2/CDK6/RBX1/YWHAB/ANAPC11/RB1/ANAPC16/CCND1/HDAC8/ATM/CDKN2A/ANAPC10/YWHAH/RBL2/CDKN1B/HDAC2/ANAPC13/PCNA/TFDP1/CDK4/CDC26/ATR/HDAC1/SKP2/CHEK2/E2F3/CDC25B/MAD2L2/TP53/CDC23/CCNB2/TGFB3/CDKN2C/MCM3/ANAPC15/MCM5/PTTG1/CCNE1/CDK1	1.12861759931917
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	28/1974	110/9376	1.20902643455835	BMP5/DCN/PITX2/RBX1/ID3/BMP4/ID1/BAMBI/ACVR2A/ZFYVE16/THSD4/BMP7/SMAD5/BMPR1A/EMP3/HDAC2/LRRC32/TFDP1/RPS6KB2/SMAD6/HDAC1/FMOD/TNF/GDF6/TMEM53/NBL1/TGFB3/NRROS	1.13877016218439
Organismal Systems	Digestive system	hsa04970	Salivary secretion	24/1974	93/9376	1.22574108572736	CST3/CALM1/CALM2/CALM3/PLCB1/ATP1B3/GUCY1A2/ATP1B1/ITPR1/ITPR2/ATP2B1/GNAS/GUCY1A1/PRKCB/PRKG1/VAMP2/CALML4/PRKACB/PRKACA/PRH1/PLCB2/ADCY7/ADRB1/BST1	1.12977661347351
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	6/1974	18/9376	1.58324890239784	NEU1/FUCA2/FUCA1/MAN2B1/MANBA/GLB1	1.27903766662674
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	41/1974	168/9376	1.15916437496985	FTL/CYBB/PPIA/SLC25A6/CHMP5/CHMP2A/SLC25A5/FTH1/PYCARD/VDAC1/BAX/TNFRSF1A/HMGB1/VDAC2/CASP1/PYGL/RIPK1/RBCK1/VDAC3/PARP1/CHMP4A/TNFRSF10B/NLRP3/BID/VPS4A/STAT2/TRADD/IFNAR2/IRF9/JAK3/CAPN1/TLR4/TNF/MAPK10/SMPD1/SHARPIN/SLC25A4/PPID/AIFM1/TICAM2/TRAF2	1.07498530048147
NA	NA	hsa04517	IgSF CAM signaling	70/1974	299/9376	1.11198083446002	NRP1/TUBA1B/CADM3/ARPC3/ARPC1B/MTSS1/PTPRD/DYNLL1/LMO7/SLIT3/MYL12B/NRP2/TUBB/ARPC2/MYL6/ARPC5/ACTR2/ROBO1/EPB41L2/LYN/MAP2K2/CD86/MAGI1/MYL12A/CDC42/GRB2/NRCAM/MYH10/ROBO2/CASK/CD28/CD209/ARPC4/DOK2/PRKCB/LCP2/VAV1/TUBA1A/ARPC1A/ANK2/NCK2/EPB41L3/ICAM1/IL1RAPL1/PTPRS/DYNLL2/UNC5C/ANK3/PTPN6/ITGAM/ARPC5L/INPP5D/PIK3CD/EPB41L1/MAPK10/VAV3/CSK/NCAM2/DOK1/PLXNA1/SRGAP3/PAK1/PIK3R3/MAPK13/GIT1/PIK3R2/ITGA4/ICAM2/MYL6B/LRFN5	1.01623184005173
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	38/1974	156/9376	1.1569895825215	CDK6/CD81/EIF3E/YWHAB/MAP2K2/RB1/BAX/TNFRSF1A/GRB2/CCND1/CYCS/RIPK1/YWHAH/BAD/HRAS/BID/STAT2/TRADD/IFNAR2/IRF9/CDK4/CLDN23/KRAS/PIK3CD/TNF/RNASEL/IFIT1/E2F3/NRAS/IKBKG/TP53/CHUK/PIK3R3/PIK3R2/APAF1/TRAF3/TRAF2/BAK1	1.02106254419798
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	70/1974	300/9376	1.10827423167849	CD14/MEF2C/HGF/ANGPT1/FGF7/CSF1R/PDGFC/MKNK1/MAP2K2/IGF1/DUSP6/CDC42/TNFRSF1A/GRB2/FGF10/MAP3K20/CSF1/PPP3R1/KITLG/BDNF/MAX/AREG/PRKCB/JUN/STMN1/NFATC3/ARRB2/VEGFB/HRAS/DUSP3/PRKACB/MAP3K1/TRADD/ARTN/NLK/CACNB4/FGFR4/CACNA2D4/DUSP9/PRKACA/KRAS/MAPKAPK3/TNF/MAPK7/ARRB1/MAP3K13/MAPK10/IRAK1/FGFR2/MAP3K11/TAOK2/MAP2K6/NRAS/IKBKG/CDC25B/TP53/RAC2/PAK1/IRAK4/CHUK/MAPT/TGFB3/MAPK13/RPS6KA1/MECOM/FGFR3/RPS6KA4/ECSIT/TRAF2/TGFA	0.984290211915554
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	21/1974	82/9376	1.21639854696419	NME2/GSTP1/MGST3/DUT/MGST2/NME4/GSTO1/ITPA/NME3/IMPDH2/GUSB/CES1/NME1/TK2/GSTA4/UMPS/CES2/UCK1/TPMT/IMPDH1/NME6	1.0163530725468
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	9/1974	31/9376	1.37895872144328	PGLS/TKT/GPI/PFKL/RPIA/RPE/G6PD/RBKS/PRPS1	1.09135934746235
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	9/1974	31/9376	1.37895872144328	ALDH9A1/HADHA/ECHS1/CNDP2/HIBCH/ACADS/ALDH7A1/CSAD/ACOX3	1.09135934746235
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	17/1974	65/9376	1.24224144649677	SPP1/PLCB1/ITPR1/MAP2K2/ITPR2/PRKCB/ARRB2/HRAS/KISS1/KCNJ5/KRAS/PIK3CD/ARRB1/PLCB2/NRAS/PIK3R3/PIK3R2	1.01202592541183
Genetic Information Processing	Transcription	hsa03040	Spliceosome	57/1974	243/9376	1.11413811650218	SF3B6/SRSF9/SNRPF/SNRPD2/LSM3/LSM7/SNU13/SNRPG/SNRPE/SNRPB2/HNRNPA3/SF3B5/SNRPD3/HNRNPA1/MAGOH/SNRPD1/BUD31/SRSF10/SNRPB/PRPF40A/LSM8/RBM8A/EIF4A3/DDX46/SRSF1/PRPF38B/SNRPC/CWC15/LSM6/CDC40/LSM4/CCDC12/LSM5/LSM2/TXNL4A/BCAS2/ALYREF/PUF60/AQR/ZMAT2/PRPF19/PPIH/PRPF31/RBMX2/PPIE/RP9/MAGOHB/PQBP1/NCBP2/SNRNP40/PHF5A/U2AF1L4/THOC3/U2AF1/DHX16/SRSF8/GPKOW	0.930918758263255
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	83/1974	362/9376	1.08903032236757	SPP1/LAMA2/CCND2/GNGT1/COL1A2/GNG10/HGF/RPS6/COL1A1/GNG5/GNG2/GNG11/CDK6/ANGPT1/FGF7/VTN/COL6A1/YWHAB/CSH1/CSF1R/PDGFC/LAMA4/MAP2K2/IGF1/MAGI1/GNB2/GRB2/LPAR6/FGF10/SYK/CCND1/CSF1/HSP90B1/EIF4E2/KITLG/BDNF/PIK3AP1/AREG/COL6A2/CREB1/YWHAH/VEGFB/GNB4/TNXB/BAD/RBL2/GNG7/HRAS/CDKN1B/LAMA5/ARTN/PKN1/ITGB5/FGFR4/IFNAR2/RPS6KB2/JAK3/TLR4/CDK4/SGK3/KRAS/PIK3CD/PIK3CG/FGFR2/LPAR5/EIF4E/PIK3R5/TSC2/EPOR/NRAS/IKBKG/TP53/COL4A4/CHUK/G6PC3/MLST8/PIK3R3/PIK3R2/IL2RA/ITGA4/FGFR3/CCNE1/TGFA	0.892109422210925
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	25/1974	101/9376	1.1756798780182	WNT2/CALM1/CALM2/GNAI2/CALM3/PLCB1/FZD4/MAP2K2/GNAS/KITLG/PRKCB/CREB1/CALML4/DVL3/HRAS/PRKACB/WNT5B/PRKACA/KRAS/PLCB2/ADCY7/NRAS/TCF7/WNT10A/WNT11	0.916664517648074
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	9/1974	32/9376	1.33586626139818	AKR1B1/GAA/GALM/GLB1/PFKL/GLA/G6PC3/GCK/GALK1	0.982787505090819
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	9/1974	32/9376	1.33586626139818	GABARAP/GABARAPL2/ATG7/ATG3/ATG10/PIK3R4/ATG4C/MLST8/ATG101	0.982787505090819
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	37/1974	155/9376	1.13381050429781	WNT2/GNAI2/CDK6/PLCB1/ITPR1/FZD4/MAP2K2/ITPR2/RB1/GNAS/CCND1/CDKN2A/CREB1/AIP/APC/DVL3/ASH2L/CDKN1B/PRKACB/AXIN2/WNT5B/CDK4/PRKACA/HSD3B2/PLCB2/ADCY7/E2F3/ORAI1/KMT2D/FH/CDKN2C/TCF7/ARMC5/AGTR1/CCNE1/WNT10A/WNT11	0.867464513367259
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	28/1974	115/9376	1.15646006783842	GNGT1/GNG10/GNG5/GNG2/GNAI2/GNG11/PLCB1/ITPR1/ITPR2/GNB2/PRKCB/CREB1/GNB4/GNG7/HRAS/PRKACB/KCNQ1/PRKACA/KRAS/PIK3CD/PIK3CG/PLCB2/ADCY7/PIK3R5/NRAS/PIK3R3/PIK3R2/KCNJ12	0.871782535035173
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	8/1974	28/9376	1.35707048776958	AKR1B1/PCBD1/PTS/MOCS2/GGH/MOCS1/CBR1/QDPR	0.977143376653319
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	32/1974	133/9376	1.14279620022701	FCER1G/HLA-C/TYROBP/HCST/FCGR3A/MAP2K2/GRB2/SYK/PPP3R1/PRKCB/SH3BP2/LCP2/VAV1/SHC1/ICAM1/TNFRSF10B/HRAS/BID/IFNAR2/PTPN6/KRAS/PIK3CD/TNF/VAV3/NRAS/RAC2/PAK1/PIK3R3/PIK3R2/ICAM2/LAT2/MICA	0.856486786152
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	32/1974	133/9376	1.14279620022701	GNGT1/GNG10/CALM1/CALM2/GNG5/GNG2/GNAI2/GNG11/CALM3/PLCB1/COMT/ITPR1/ITPR2/PPP1CA/GNB2/GNAS/KIF5B/PRKCB/CREB1/ARRB2/GNB4/CALML4/GNG7/PRKACB/PPP1CC/GRIA4/PRKACA/KCNJ5/ARRB1/MAPK10/PLCB2/MAPK13	0.856486786152
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/1974	24/9376	1.38534278959811	EXT1/HS2ST1/B4GALT7/B3GAT3/B3GALT6/XYLT2/GLCE	0.976079700359623
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	11/1974	41/9376	1.27432228729582	GCSH/GRHPR/DLD/PGAM1/GATM/SHMT2/ALDH7A1/PHGDH/GAMT/ALAS1/SRR	0.90903484837079
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	33/1974	138/9376	1.13580899519845	RPS6/CALM1/CALM2/CALM3/MKNK1/MAP2K2/PPP1CA/GRB2/FLOT1/EIF4E2/PYGL/SHC1/PDE3B/ACACB/BAD/CALML4/HRAS/PRKACB/PPP1CC/RPS6KB2/PRKACA/KRAS/PIK3CD/MAPK10/EXOC7/EIF4E/TSC2/NRAS/G6PC3/PIK3R3/PIK3R2/PHKG2/GCK	0.829972632646484
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	24/1974	98/9376	1.16320327523107	CALM1/CALM2/CALM3/PLCB1/ITPR1/ITPR2/PLCD3/PRKCB/CALML4/PIP4P2/PI4KB/INPP5D/PIK3CD/SYNJ1/PLCB2/INPP4A/MTMR6/PI4K2A/DGKZ/PIK3R3/PIK3R2/MTMR4/PI4K2B/CDS1	0.83868600454408
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	26/1974	107/9376	1.15414405969188	CALM1/CALM2/LDHB/CALM3/PLCB1/ITPR1/ITPR2/GNAS/PRMT1/PPP3R1/PYGL/PDHB/CREB1/PDE3B/ACACB/PGAM1/CALML4/PFKL/PRKACB/PRKACA/CPT1A/PLCB2/SLC2A1/G6PC3/PHKG2/GCK	0.828107871038149
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	19/1974	76/9376	1.18743667679838	CALM1/CALM2/GNAI2/CALM3/PLCB1/ATP1B3/ATP1B1/ITPR1/ITPR2/GNAS/HRH2/PRKCB/CALML4/PRKACB/KCNQ1/PRKACA/PLCB2/ADCY7/CFTR	0.84723632859224
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	28/1974	116/9376	1.14649058449499	CYBA/CYBB/GNAI2/THY1/MMP2/VCAM1/MYL12B/NCF4/MYL12A/CDC42/PRKCB/VAV1/PECAM1/ICAM1/NCF2/ITGAM/CDH5/CLDN23/PIK3CD/VAV3/SIPA1/RAC2/PIK3R3/MAPK13/PIK3R2/TXK/ITGA4/RASSF5	0.819818822281976
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	10/1974	37/9376	1.28371532626852	PMM1/NANS/GALK2/GPI/UXS1/FPGT/GCK/GMPPA/MPI/GALK1	0.892931498802452
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	10/1974	37/9376	1.28371532626852	PLCB1/VCAM1/LAMA4/PRKCB/HBB/ICAM1/TNF/IDO2/PLCB2/IDO1	0.892931498802452
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	16/1974	63/9376	1.2062848780174	PRDM6/SMYD3/ALDH9A1/HADHA/ECHS1/DLD/COLGALT1/TMLHE/SETDB2/ALDH7A1/KMT2D/KMT5A/ACAT2/MECOM/SMYD2/HADH	0.848354832084657
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	18/1974	72/9376	1.18743667679838	CXCL8/RIPK1/PIN1/ADAR/MAP3K1/TRADD/TNF/MAPK10/ISG15/IKBKG/CHUK/MAPK13/SIKE1/TRIM25/TRAF3/CASP10/IFIH1/TRAF2	0.824462002951319
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	39/1974	166/9376	1.11590434687077	MEF2C/CALM1/CALM2/SLC25A6/GNAI2/CALM3/PLCB1/ATP1B3/GUCY1A2/SLC25A5/ATP1B1/ITPR1/MAP2K2/ITPR2/ATP2B1/PPP1CA/VDAC1/VDAC2/GUCY1A1/GTF2I/PPP3R1/PRKG1/VDAC3/CREB1/NFATC3/PDE3B/BAD/CALML4/PPP1CC/PIK3CG/PLCB2/ADCY7/PIK3R5/SLC25A4/PDE5A/ADRB1/AGTR1/ADRA2A/MEF2B	0.778052002726222
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	9/1974	33/9376	1.29538546559823	VAMP8/VAMP5/VAMP2/BET1/USE1/GOSR2/STX4/STX6/VAMP4	0.877783856940361
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	15/1974	59/9376	1.20756272216784	GNAI2/GNAS/PRKG1/PDE3B/PRKACB/PLAAT3/MGLL/PRKACA/PIK3CD/ADCY7/PIK3R3/PIK3R2/TSHR/ADRB1/PTGS1	0.825889582044456
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	22/1974	90/9376	1.16104919509175	IGF1/BAX/EIF4E2/APPL1/CREB1/CAT/SESN3/HRAS/PRKACB/RPS6KB2/PRKACA/KRAS/PIK3CD/ADCY7/EIF4E/TSC2/NRAS/TP53/PIK3R3/PIK3R2/ATG101/KL	0.792775363876315
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	34/1974	144/9376	1.1214679725318	CD14/C1QA/C1QB/C1QC/LY96/CXCL8/C3AR1/TNFRSF1A/C2/ADH5/ALDH9A1/CCND1/ACADVL/RIPK1/ACACB/TRADD/TLR4/TNF/CPT1A/ACADM/MAPK10/IRAK1/MAP2K6/IKBKG/SCD5/ALDH7A1/IL17RC/IRAK4/CHUK/MAPK13/TCF7/TRAF3/ACOX3/TIRAP	0.758542297444397
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	35/1974	149/9376	1.11571231377029	FCER1G/PLCB1/PDGFC/MAP2K2/CXCL8/CYTH4/PLD1/GNAS/GRB2/LPAR6/SYK/KITLG/PLPP3/AGPAT2/SHC1/HRAS/AGPAT1/RALB/KRAS/PIK3CD/PIK3CG/PTGFR/PLCB2/ADCY7/LPAR5/PIK3R5/TSC2/CYTH2/NRAS/DGKZ/PIK3R3/PIK3R2/AGPAT5/AGTR1/PLD2	0.73523660950406
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	29/1974	122/9376	1.12903815170993	MAP2K2/PTPRC/CDC42/DLG1/GRB2/CD28/CD4/PPP3R1/JUN/LCP2/VAV1/NCK2/NFATC3/HRAS/PTPN6/TEC1/CDK4/KRAS/PIK3CD/TNF/MAPK10/VAV3/NRAS/IKBKG/PAK1/CHUK/PIK3R3/MAPK13/PIK3R2	0.740828998124137
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	18/1974	73/9376	1.17117042095183	PPIA/BST2/RAN/CD4/SERINC5/XPO1/SMARCB1/SUPT4H1/PIN1/FEZ1/CHMP4A/MLLT1/VPS4A/PSIP1/NELFCD/MAP1S/APOBEC3C/BICD1	0.758164264235298
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	10/1974	38/9376	1.24993334399829	PTPRC/CD4/RFXANK/JAK3/IKBKG/ORAI1/CD40/BTK/TAP2/BLNK	0.797211831338576
Human Diseases	Substance dependence	hsa05032	Morphine addiction	22/1974	91/9376	1.1482904127281	GNGT1/GNG10/GNG5/GNG2/GNAI2/GNG11/PDE4D/GNB2/GNAS/PRKCB/ARRB2/PDE3B/GNB4/GRK2/GRK3/GNG7/PRKACB/PRKACA/KCNJ5/ARRB1/ADCY7/GABRA3	0.734053118511874
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	17/1974	69/9376	1.1702274495984	CALM1/CALM2/CALM3/PPP1CA/GNAS/PPP3R1/PRKCB/JUN/CREB1/CALML4/PRKACB/HDAC2/PPP1CC/GRIA4/HDAC1/PRKACA/GRIN2C	0.73288182711872
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	35/1974	150/9376	1.10827423167849	WNT2/HGF/FGF7/RARB/FZD4/MAP2K2/RB1/BAX/GRB2/FGF10/CCND1/SHC1/APC/DVL3/HRAS/CDKN1B/LRP6/AXIN2/RPS6KB2/WNT5B/KRAS/PIK3CD/FGFR2/E2F3/NRAS/DDB2/TP53/TGFB3/PIK3R3/PIK3R2/TCF7/CCNE1/WNT10A/WNT11/BAK1	0.690317188186129
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	5/1974	17/9376	1.39698432564515	INMT/PAPSS2/SEPHS2/KYAT3/SEPHS1	0.845994946173395
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	16/1974	65/9376	1.16916842023225	AKR1B1/AKR1A1/ALDH9A1/PLPP3/AGPAT2/AGPAT1/GK/MGLL/GLA/MBOAT2/ALDH7A1/DGKZ/PLPP5/LCLAT1/DGAT1/AGPAT5	0.706744570394091
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	41/1974	178/9376	1.09404278087042	SERPINF1/WNT2/CCND2/PRICKLE1/RBX1/PLCB1/FZD4/BAMBI/RSPO3/CSNK2B/RSPO2/CCND1/INVS/PPP3R1/PRKCB/JUN/NFATC3/ZNRF3/APC/DVL3/PRKACB/LRP6/FRZB/NLK/AXIN2/CTBP1/CTNNBIP1/WNT5B/CBY1/PRKACA/MAPK10/PLCB2/NKD2/CACYBP/TP53/RAC2/RUVBL1/CCAR2/TCF7/WNT10A/WNT11	0.654144107090896
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	20/1974	83/9376	1.14451727884181	CCL4/CCL4L2/POLR2L/IFI16/POLR2K/PYCARD/POLR2E/CASP1/POLR2F/POLR1D/RIPK1/ADAR/GSDMD/NLRP3/G3BP1/POLR3GL/IKBKG/CHUK/POLR3A/DDX41	0.682913228078156
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	13/1974	52/9376	1.18743667679838	PLTP/NPC2/CD36/TSPO/APOE/LRP1/VDAC1/LRPAP1/VDAC2/STARD3NL/ANGPTL4/VDAC3/MYLIP	0.699906113714334
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	29/1974	125/9376	1.1019412360689	FCER1G/GNAI2/PLCB1/ASAH1/MAP2K2/ORMDL1/PLD1/BAX/TNFRSF1A/CERS2/PRKCB/HRAS/BID/TRADD/KRAS/PIK3CD/TNF/MAPK10/PLCB2/NSMAF/SMPD1/NRAS/TP53/RAC2/PIK3R3/MAPK13/PIK3R2/PLD2/TRAF2	0.592509384381232
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	34/1974	148/9376	1.09115802732824	WNT2/CDK6/FGF7/FZD4/MAP2K2/IGF1/RB1/BAX/GRB2/FGF10/CCND1/JUN/SHC1/APC/DVL3/HRAS/LRP6/AXIN2/RPS6KB2/WNT5B/CDK4/KRAS/PIK3CD/E2F3/NRAS/DDB2/TP53/PIK3R3/PIK3R2/TCF7/NOTCH3/WNT10A/WNT11/BAK1	0.577240315224952
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	11/1974	44/9376	1.18743667679838	DAD1/TMEM258/OSTC/KRTCAP2/RPN2/DDOST/MAN1C1/TUSC3/MAN1B1/MGAT2/MAN2A2	0.643543963441167
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	26/1974	112/9376	1.10261977131278	LAMA2/GNAI2/LY96/LAMA4/TNFRSF1A/CYCS/BAD/HLA-DPA1/LAMA5/IL10RA/TLR4/PIK3CG/TNF/ALOX5/MAPK10/IRAK1/PIK3R5/HLA-DQA2/MAP2K6/IKBKG/IRAK4/HLA-DMA/CHUK/TGFB3/MAPK13/CD40	0.564190088865602
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	44/1974	195/9376	1.07173771854623	CYBA/FCGR3A/CYBB/SLC25A6/CR1/PLCB1/NCF4/SLC25A5/ATG7/MAP2K2/FCGR2A/VDAC1/CLCN5/HMGB1/HDAC9/VDAC2/FCGR1A/CASP1/SYK/ELANE/HDAC8/CLEC7A/PRKCB/VDAC3/HAT1/GSDMD/FPR1/HDAC2/NCF2/ITGAM/CLCN3/HDAC3/TLR4/HDAC1/PIK3CD/TLR7/PLCB2/SELPLG/SLC25A4/RAC2/PIK3R3/SIGLEC9/MAPK13/PIK3R2	0.522762642728491
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	23/1974	99/9376	1.10347650773183	PDGFC/WASF2/MAP2K2/HIF1A/PLD1/GRB2/PLPP3/PRKCB/JUN/WAS/HRAS/RPS6KB2/KRAS/PIK3CD/MAPK10/CHKB/TSC2/NRAS/RAC2/DGKZ/PIK3R3/PIK3R2/PLD2	0.534490824436981
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	38/1974	169/9376	1.067990383866	RPS27A/UBA52/VAMP8/UBB/GABARAP/GABARAPL2/ITPR1/ATG7/MAP2K2/HIF1A/HMGB1/RRAGA/WDR45B/BAD/ATG3/RAB8A/NRBF2/HRAS/PRKACB/VPS16/EIF2AK4/RPS6KB2/PRKACA/KRAS/PIK3CD/MAPK10/ATG10/TSC2/NRAS/PIK3R4/ATG4C/VPS11/MLST8/PIK3R3/PIK3R2/ATG101/ATG16L2/MTMR4	0.460592058778606
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	19/1974	82/9376	1.10055106630094	B2M/LGMN/HLA-C/CALR/PDIA3/PSME1/HSPA5/CD4/PSME2/CREB1/HLA-DPA1/RFXANK/HSPA4/TAPBP/TNF/NFYC/HLA-DQA2/HLA-DMA/TAP2	0.472255413063026
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	30/1974	133/9376	1.07137143771282	CCND2/GABARAP/KLF2/GABARAPL2/MAP2K2/IGF1/GRB2/CCND1/PRMT1/ATM/CCNG2/CAT/RBL2/HRAS/CDKN1B/NLK/SGK3/KRAS/PIK3CD/SKP2/MAPK10/HOMER3/NRAS/CHUK/CCNB2/G6PC3/TGFB3/PIK3R3/MAPK13/PIK3R2	0.428083472897204
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	41/1974	184/9376	1.05836747279856	NRP1/EPHA3/CFL1/GNAI2/SLIT3/MYL12B/ROBO1/MYL12A/CDC42/ROBO2/PPP3R1/BMP7/NCK2/NFATC3/SEMA3B/PLXNC1/HRAS/UNC5C/EFNB2/PTCH1/WNT5B/KRAS/PIK3CD/EPHA5/LRRC4/FES/NRAS/PLXNA1/RAC2/SEMA3D/SRGAP3/PAK1/SEMA3G/PIK3R3/PIK3R2/RHOD/EPHA7/RGS3/SEMA6A/ABLIM3/SEMA6B	0.412913864230128
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/1974	19/9376	1.24993334399829	ARSB/HYAL2/GLB1/NAGLU/GUSB	0.563141272199677
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1974	19/9376	1.24993334399829	GCSH/PDHB/DLD/DLAT/LIAS	0.563141272199677
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	11/1974	46/9376	1.13580899519845	FTL/BLVRB/FTH1/BLVRA/UROD/MMAB/GUSB/UROS/COX15/FECH/ALAS1	0.47681652904547
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/1974	28/9376	1.18743667679838	ATP6V1G1/ATP6V1F/ATP6V0E1/ATP6V1D/ATP6V1A/SLC12A7/TCIRG1	0.512930957748702
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	14/1974	60/9376	1.10827423167849	MAP2K2/CDC42/PPP3R1/PRKCB/BAD/HRAS/KRAS/PIK3CD/MAPKAPK3/NRAS/RAC2/PIK3R3/MAPK13/PIK3R2	0.43448087846788
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	4/1974	15/9376	1.26659912191827	ACP1/AK1/TPK1/NTPCR	0.533614833387631
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	13/1974	56/9376	1.10261977131278	CD14/EEF1G/CR1/CXCL8/PYCARD/VCP/CASP1/CYCS/RAB1B/ITGAM/TLR4/TNF/APAF1	0.397742291790385
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	22/1974	98/9376	1.06626966896181	CALM1/CALM2/CALM3/PLCB1/ATP1B3/ATP1B1/ITPR1/ITPR2/ATP2B1/GNAS/NR4A2/PRKCB/CREB1/CALML4/PRKACB/PRKACA/KCNJ5/HSD3B2/PLCB2/ADCY7/ORAI1/AGTR1	0.340553483411096
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	9/1974	38/9376	1.12494000959846	ENPP1/NT5C/NNT/NMRK1/SIRT2/QPRT/SARM1/BST1/NAPRT	0.398520870669145
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	17/1974	75/9376	1.07660925363053	TKT/IDH2/PGAM1/IDH3G/PFKL/BCAT1/RPIA/PYCR2/SHMT2/CS/RPE/ARG2/PHGDH/ACY1/GOT1/PRPS1/GOT2	0.34397882822309
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	17/1974	75/9376	1.07660925363053	PLCB1/ATP1B3/ATP1B1/ITPR1/ITPR2/GNAS/HSPA5/GPX7/HSP90B1/PRKCB/CREB1/GPX8/PRKACB/PRKACA/PLCB2/ADCY7/TSHR	0.34397882822309
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	44/1974	201/9376	1.03974554784336	CD14/MEF2C/CCND2/PROM1/RUNX1T1/CSF1R/BMP2K/NR4A3/RUNX1/CD86/CXCL8/IGF1/NFKBIZ/DUSP6/BAX/FCGR1A/ETV5/SPI1/ELANE/ATM/MAX/FLI1/REL/LMO2/MLLT1/CDKN1B/LYL1/PML/HDAC2/ITGAM/PLAU/HOXA10/BCL2A1/HDAC1/TSPAN7/HHEX/DDB2/TP53/HOXA9/CEBPA/CDKN2C/CD40/BAK1/ETV1	0.294149525267984
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	23/1974	103/9376	1.06062305112088	SAP18/SRRM1/PPP1CA/MAGOH/RNMT/UPF3A/PNN/RBM8A/EIF4A3/PABPN1/ALYREF/PPP1CC/UPF3B/MAGOHB/PYM1/NCBP2/CSTF2T/PABPC4L/CSTF1/GLE1/CPSF4/CSTF3/CPSF3	0.319470634865323
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	23/1974	103/9376	1.06062305112088	COL14A1/COL3A1/COL1A2/COL15A1/COL1A1/SLC16A10/COL5A2/COL5A1/COL6A1/ATP1B3/ATP1B1/COL8A2/COL21A1/ELN/COL6A2/PRCP/KCNQ1/COL4A4/SLC7A7/KCNE3/SLC1A1/COL7A1/CPA1	0.319470634865323
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	26/1974	117/9376	1.05549926826523	YY1/SMARCE1/SMARCB1/RBBP7/ZNHIT1/BRD7/CDK2AP1/BRD9/MTA3/HDAC2/SMARCA4/BCL7C/BRD8/MBD3/SMARCD1/HDAC1/MEAF6/TFPT/NFRKB/MCRS1/RUVBL1/ACTL6A/YEATS4/DMAP1/MRGBP/SMARCD3	0.311948439884601
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	27/1974	122/9376	1.05117345159201	GNAI2/PLCB1/CSH1/ITPR1/MAP2K2/IGF1/ITPR2/GNAS/GRB2/JUNB/PRKCB/CREB1/SHC1/HRAS/PRKACB/MAP3K1/PRKACA/KRAS/PIK3CD/MAPK10/PLCB2/ADCY7/MAP2K6/NRAS/PIK3R3/MAPK13/PIK3R2	0.293795101457133
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	16/1974	71/9376	1.0703654551422	CCND2/MAP2K2/GRB2/CCND1/SHC1/HRAS/TNFRSF11A/KRAS/PIK3CD/IRF1/MAPK10/NRAS/PIK3R3/MAPK13/PIK3R2/GCK	0.307337220131409
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	14/1974	62/9376	1.07252345001144	IGF1/CAT/HRAS/PRKACB/HDAC2/RPS6KB2/HDAC1/PRKACA/KRAS/PIK3CD/ADCY7/NRAS/PIK3R3/PIK3R2	0.295863135607869
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	23/1974	104/9376	1.05042475255241	PLD1/PLD3/ETNK1/PLPP3/AGPAT2/LPCAT2/AGPAT1/PEMT/PLAAT3/PLD4/PTDSS2/MBOAT2/CHKB/PTDSS1/GPD1L/PLB1/DGKZ/PLPP5/LCLAT1/AGPAT5/PLD2/PNPLA6/CDS1	0.267028985542388
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	17/1974	76/9376	1.06244334239855	PLTP/DBI/CD36/FABP5/SCP2/ANGPTL4/SLC27A4/ME1/MMP1/GK/CPT1A/ACADM/ACAA1/CPT2/SCD5/FADS2/ACOX3	0.282251419852493
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	37/1974	170/9376	1.03376840097741	TUBA1B/ARPC3/ARPC1B/MYL12B/ARPC2/MYL6/RUNX1/ARPC5/ACTR2/MAGI1/MYL12A/RAB13/CDC42/DLG1/MYH10/CCND1/HCLS1/ARPC4/JUN/TUBA1A/ARPC1A/RAB8A/WAS/PRKACB/MAP3K1/PCNA/ARPC5L/NF2/ARHGEF2/CDK4/CLDN23/HSPA4/PRKACA/DLG3/MAPK10/CFTR/MYL6B	0.229447929757139
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	9/1974	39/9376	1.09609539396773	GCSH/AHCYL2/DLD/MTHFR/MTHFS/GART/SHMT2/TYMS/ALDH7A1	0.31053879804616
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	15/1974	67/9376	1.06337612847616	LDHB/AKR1A1/ADH5/ALDH9A1/PDHB/DLD/PGAM1/GALM/GPI/PFKL/MINPP1/ALDH7A1/G6PC3/DLAT/GCK	0.2688414713818
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	19/1974	86/9376	1.04936264461252	MAP2K2/GRB2/AREG/PRKCB/JUN/NCK2/SHC1/BAD/HRAS/CDKN1B/RPS6KB2/KRAS/PIK3CD/MAPK10/NRAS/PAK1/PIK3R3/PIK3R2/TGFA	0.237478588892009
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	10/1974	44/9376	1.07948788799853	GTF2A2/GTF2H5/GTF2I/GTF2B/TAF10/TAF11/ERCC3/TAF6/GTF2H3/TAF9B	0.272913238550234
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	26/1974	119/9376	1.03775978476497	CCL2/VCAM1/TNFRSF1A/CSF1/TNFRSF1B/JUNB/RIPK1/JUN/CREB1/ICAM1/TRADD/PIK3CD/IRF1/TNF/MAPK10/MAP2K6/IKBKG/CHUK/PIK3R3/MAPK13/PIK3R2/BCL3/TRAF3/CASP10/RPS6KA4/TRAF2	0.21406838416438
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	23/1974	105/9376	1.04042070729001	LAMA2/RYR2/TPM3/SGCE/IGF1/GNAS/EMD/SGCB/SGCA/PRKACB/SNTA1/CACNB4/ITGB5/CACNA2D4/PRKACA/TNF/TTN/ADCY7/DTNA/TGFB3/ADRB1/MYL3/ITGA4	0.215089861346162
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	30/1974	138/9376	1.03255363199859	CALM1/CALM2/CALM3/RBX1/YWHAB/ANAPC11/ITPR1/IGF1/ITPR2/PPP1CA/ANAPC16/PPP3R1/ANAPC10/YWHAH/CALML4/PRKACB/ANAPC13/PPP1CC/CDC26/PRKACA/ADCY7/MAD2L2/CDC23/CCNB2/MAPK13/RPS6KA1/ANAPC15/PTTG1/CCNE1/CDK1	0.198945759171506
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	34/1974	157/9376	1.02860756716293	BMP5/WNT2/CCND2/BMP4/YWHAB/ID1/FZD4/PPP1CA/DLG1/CCND1/MOB1A/AREG/BMP7/BMPR1A/YWHAH/APC/DVL3/AXIN2/PPP1CC/NF2/WNT5B/GLI2/DLG3/LATS1/NKD2/MOB1B/GDF6/TGFB3/TCF7/LIMD1/RASSF1/DLG4/WNT10A/WNT11	0.186669565641577
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	24/1974	110/9376	1.03630837247859	GNAI2/ANAPC11/IGF1/ANAPC16/ANAPC10/PDE3B/PRKACB/ANAPC13/CDC26/PRKACA/KRAS/PIK3CD/MAPK10/ADCY7/CDC25B/MAD2L2/CDC23/CCNB2/PIK3R3/MAPK13/PIK3R2/RPS6KA1/ANAPC15/CDK1	0.197806996533483
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/1974	35/9376	1.08565639021566	AKR1B1/PMM1/PFKL/TIGAR/PFKFB2/FPGT/GMPPA/MPI	0.262169264850957
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	30/1974	139/9376	1.02512518860292	CALM1/CALM2/GNAI2/CALM3/MMP2/PLCB1/ITPR1/MAP2K2/ITPR2/GNAS/GRB2/HSP90B1/KRT10/JUN/CREB1/SHC1/CALML4/HRAS/PRKACB/PRKACA/KCNJ5/KRAS/PIK3CD/PLCB2/ADCY7/EBAG9/NRAS/PIK3R3/PIK3R2/TGFA	0.15411181342297
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	31/1974	144/9376	1.02251491613194	WNT2/ID3/BMP4/ID1/FZD4/MAP2K2/IGF1/ACVR2A/GRB2/SMAD5/BMPR1A/APC/DVL3/HRAS/FGFR4/AXIN2/WNT5B/JAK3/DUSP9/KRAS/PIK3CD/FGFR2/NRAS/PIK3R3/MAPK13/PIK3R2/TCF7/FGFR3/WNT10A/WNT11/PCGF6	0.140600981917405
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	18/1974	83/9376	1.03006555095763	MBD5/CSNK2B/YY1/MAX/RBBP7/SFMBT1/HDAC2/TFDP1/HDAC1/MTF2/BAP1/CBX6/EED/RNF2/KDM2B/L3MBTL2/PHC1/PCGF6	0.142074100917011
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	19/1974	88/9376	1.0255134935986	F13A1/C1QA/CFD/C1QB/C1QC/C1R/CR1/A2M/VTN/PROS1/C3AR1/C2/C6/PROCR/C4BPB/PLAUR/ITGAM/PLAU/CFI	0.124175190787263
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	17/1974	79/9376	1.02209739268721	CLTA/AP2S1/ATP6V1G1/CLTC/ATP6V1F/ATP6V0B/SYT1/AP2M1/ATP6V0E1/ATP6V1D/VAMP2/ATP6V1A/NSF/ATP6V1H/TCIRG1/SLC1A1/SLC1A2	0.101851595277361
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	9/1974	41/9376	1.04262732596931	SEM1/SSBP1/ATM/RPA3/BABAM1/POLD2/MUS81/RBBP8/NBN	0.141256203354618
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	6/1974	27/9376	1.05549926826523	HADHA/HMGCLL1/ECHS1/ACADS/ACAT2/HADH	0.14913213363009
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	23/1974	109/9376	1.0022401308757	CD36/PPP1CA/TNFRSF1A/PYGL/PRKCB/SLC27A4/CREB1/ACACB/TBC1D4/PPP1CC/RPS6KB2/PIK3CD/TNF/CPT1A/MAPK10/SLC2A1/MLX/PTPA/G6PC3/PIK3R3/PIK3R2/RPS6KA1/SLC27A3	0.0121479146349784
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	21/1974	100/9376	0.997446808510638	CXCL14/CCL3/CCL2/CCL4/CCL4L2/CCL3L1/CSF1R/CXCL8/TNFRSF1A/CCR1/CSF1/TNFRSF1B/CCL8/TNFRSF10B/IL10RA/CCL13/TNF/CX3CR1/IL2RA/TNFRSF14/CCL28	-0.01325524288791
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	5/1974	23/9376	1.03255363199859	FKRP/FKTN/B4GAT1/POMGNT1/RXYLT1	0.080718405167158
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	23/1974	110/9376	0.993128856958644	CYBB/ELOB/RPS6/LDHB/ANGPT1/RBX1/MKNK1/MAP2K2/ELOC/HIF1A/IGF1/EIF4E2/PDHB/PRKCB/CDKN1B/PFKL/RPS6KB2/TLR4/PIK3CD/SLC2A1/EIF4E/PIK3R3/PIK3R2	-0.0374337948792434
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	24/1974	115/9376	0.991251486718647	GNGT1/GNG10/GNG5/GNG2/GNAI2/GNG11/PLCB1/ITPR1/ITPR2/GNB2/GNAS/PRKCB/GNB4/GNG7/HRAS/PRKACB/PRKACA/KCNJ5/KRAS/ALOX5/PLCB2/NRAS/PTGS1/HTR2C	-0.0487459911757382
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1974	38/9376	0.999946675198635	ATP1B3/ATP1B1/IGF1/PRKCB/KRAS/PIK3CD/PIK3R3/PIK3R2	-0.000170090000285518
NA	NA	hsa04518	Integrin signaling	32/1974	154/9376	0.98696035474151	SPP1/LAMA2/CCND2/COL1A2/HGF/COL1A1/VTN/COL6A1/VCAM1/PDGFC/LAMA4/IGF1/CDC42/CCND1/FREM1/COL6A2/NCK2/VEGFB/ICAM1/TNXB/FERMT3/LAMA5/ITGB5/ITGAM/PIK3CD/PARVB/RAC2/COL4A4/PIK3R3/PIK3R2/ITGA4/ICAM2	-0.0842554980444811
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	48/1974	232/9376	0.982706215281417	TMSB4X/PFN1/ARPC3/CFL1/ARPC1B/FGF7/BRK1/MYL12B/ARPC2/PDGFC/ARPC5/WASF2/ACTR2/MAP2K2/PPP1CA/ABI2/MYL12A/CDC42/MYH10/FGF10/NCKAP1L/CYFIP1/ARPC4/VAV1/ARPC1A/C6/APC/HRAS/ITGB5/FGFR4/ITGAM/ARPC5L/PPP1CC/SCIN/KRAS/PIK3CD/FGFR2/VAV3/LPAR5/NRAS/RAC2/PAK1/PFN2/PIK3R3/GIT1/PIK3R2/ITGA4/FGFR3	-0.137736995104254
Cellular Processes	Cell motility	hsa04814	Motor proteins	40/1974	194/9376	0.979329217978044	TUBA1B/TPM3/DYNLL1/MYL12B/TUBB/CAPZB/DYNLT1/MYL6/CAPZA2/DYNLRB1/MYL12A/DCTN3/KIF5B/MYH10/KIF26B/DNAH8/KIF1B/DCTN4/TNNT3/MYO1B/DCTN6/TUBA1A/MYO5A/DYNLL2/DCTN1/DYNC1LI1/DCTN2/ACTR1A/TNNT1/MYO1F/KIF20B/TUBG1/MYL3/KIF7/KIF3A/DNAL4/MYO7A/MYL6B/DYNC2LI1/DNALI1	-0.150235926636852
Human Diseases	Immune disease	hsa05330	Allograft rejection	8/1974	39/9376	0.974307016860208	HLA-C/CD86/CD28/HLA-DPA1/TNF/HLA-DQA2/HLA-DMA/CD40	-0.0830286215916877
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	18/1974	89/9376	0.960622929544756	GNGT1/GNG10/GNG5/GABARAP/GNG2/GNAI2/GNG11/GABARAPL2/GNB2/PRKCB/GNB4/GNG7/PRKACB/NSF/PRKACA/ADCY7/SLC12A5/GABRA3	-0.192745991657257
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	20/1974	99/9376	0.959544789332023	C1QA/CFD/FCGR3A/C1QB/C1QC/C1R/FCGR2A/C3AR1/C2/FCGR1A/KRT10/ICAM1/HLA-DPA1/FPR1/ITGAM/PTAFR/SELPLG/HLA-DQA2/HLA-DMA/CFI	-0.208964714568232
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	14/1974	70/9376	0.949949341438703	CD36/TNFRSF1A/TNFRSF1B/APPL1/ACACB/TRADD/TNF/CPT1A/MAPK10/SLC2A1/IKBKG/CHUK/G6PC3/TRAF2	-0.217051086503422
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/1974	20/9376	0.949949341438703	SQLE/LBR/FDFT1/EBP	-0.115708259124004
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	20/1974	100/9376	0.949949341438703	CD14/CR1/CD36/CSF1R/FCGR1A/CD4/CSF1/KITLG/CD9/HLA-DPA1/ITGAM/TNF/CD33/HLA-DQA2/CD37/EPOR/HLA-DMA/IL2RA/ITGA4/CD7	-0.259844840739183
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	23/1974	115/9376	0.949949341438703	MEF2C/NACA/GNAI2/PDE4D/PLCB1/EGR1/ITPR1/ITPR2/PLD1/GNAS/NR4A2/PRKCB/CREB1/ARRB2/PRKACB/LRP6/PRKACA/ARRB1/PLCB2/ADCY7/KL/PLD2/MMP24	-0.278878122728466
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	10/1974	51/9376	0.931322883763435	ENPP2/PLD1/PLD3/PLPP3/LPCAT2/PLAAT3/PLD4/AGPS/PLB1/PLD2	-0.253955364127671
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	7/1974	36/9376	0.923561859732072	ENPP1/PYGL/GAA/GPI/G6PC3/GYG1/GCK	-0.237286262836992
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	5/1974	26/9376	0.913412828306445	PLAAT3/ACAA1/PLB1/FADS2/ACOX3	-0.228306930152445
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1974	16/9376	0.890577507598784	MIF/GOT1/GOT2	-0.226210803189477
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1974	16/9376	0.890577507598784	NAGA/GLA/ST3GAL2	-0.226210803189477
Human Diseases	Immune disease	hsa05310	Asthma	6/1974	32/9376	0.890577507598784	FCER1G/HLA-DPA1/TNF/HLA-DQA2/HLA-DMA/CD40	-0.320184164554475
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	18/1974	93/9376	0.919305814295519	LMO7/MYL12B/WASF2/MYL12A/CDC42/PTPRJ/CSNK2B/ACP1/PDCD10/WAS/NLK/PTPN6/CCM2/CDH5/RAC2/TCF7/PTPRB/ARHGAP29	-0.403853837942101
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	15/1974	78/9376	0.913412828306445	PLCB1/PLCD3/PI4KB/INPP5D/PIK3CD/SYNJ1/PIK3CG/PLCB2/MINPP1/INPP4A/MTMR6/PI4K2A/FIG4/MTMR4/PI4K2B	-0.396543427777489
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	12/1974	63/9376	0.904713658513051	PTGDS/HPGDS/GPX4/LTC4S/TBXAS1/PLAAT3/ALOX5/PLB1/CBR1/PTGR1/PTGS1/PTGES2	-0.391868899984532
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	9/1974	48/9376	0.890577507598784	PLCB1/ATP1B3/ATP1B1/PRKCB/PIK3CD/PLCB2/G6PC3/PIK3R3/PIK3R2	-0.392480084879489
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1974	22/9376	0.863590310398821	HNMT/ALDH9A1/CNDP2/ALDH7A1	-0.330782519120137
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	8/1974	43/9376	0.883673805989491	CD36/PLPP3/AGPAT2/SLC27A4/AGPAT1/ACAT2/DGAT1/GOT2	-0.394807856030244
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	30/1974	154/9376	0.925275332570165	RYR2/CALM1/CALM2/GNAI2/CALM3/TPM3/PLCB1/ATP1B3/CREM/ATP1B1/ATP2B1/PPP1CA/GNAS/SCN1B/CREB1/CALML4/PRKACB/KCNQ1/CACNB4/CACNA2D4/PPP1CC/PRKACA/PIK3CG/PLCB2/ADCY7/PIK3R5/MAPK13/ADRB1/MYL3/AGTR1	-0.482832465584871
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1974	17/9376	0.838190595387091	NRP2/MYH10/CD209	-0.344824542690402
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	50/1974	254/9376	0.934989509290062	HGF/RYR2/CALM1/CALM2/SLC25A6/CALM3/FGF7/PLCB1/PDGFC/SLC25A5/ITPR1/ITPR2/ATP2B1/VDAC1/GNAS/VDAC2/ASPH/GNA14/FGF10/HRH2/PPP3R1/PLCD3/HRH1/PRKCB/VDAC3/NFATC3/VEGFB/CALML4/PRKACB/MCOLN2/FGFR4/CYSLTR1/GNA15/PRKACA/PTGFR/PTAFR/PLCB2/ADCY7/FGFR2/GRIN2C/SLC25A4/RYR1/ORAI1/ADRB1/PHKG2/FGFR3/HTR2C/AGTR1/TGFA/TFEB	-0.542425303333509
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	9/1974	49/9376	0.872402456423299	GNAI2/GNAS/BDNF/JUN/CREB1/PRKACB/PRKACA/GRIN2C/DLG4	-0.462438556998383
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	8/1974	44/9376	0.863590310398821	HLA-C/CD86/CD28/HLA-DPA1/ICA1/TNF/HLA-DQA2/HLA-DMA	-0.46834821123163
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	12/1974	65/9376	0.876876315174188	PLCB1/ITPR1/ITPR2/GNAS/CREB1/PRKACB/PRKACA/HSD3B2/PLCB2/ADCY7/ORAI1/AGTR1	-0.514380849676856
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1974	23/9376	0.826042905598872	ARG2/ACY1/GOT1/GOT2	-0.43133556428296
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1974	23/9376	0.826042905598872	ATP6AP2/PRCP/NLN/AGTR1	-0.43133556428296
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1974	12/9376	0.791624451198919	CD209/NCAM2	-0.372984985065502
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/1974	50/9376	0.854954407294833	CD86/CD28/TNFSF13B/HLA-DPA1/HLA-DQA2/HLA-DMA/ITGA4/CD40/CCL28	-0.531039108091309
Organismal Systems	Sensory system	hsa04744	Phototransduction	5/1974	29/9376	0.818921846067848	GNGT1/CALM1/CALM2/CALM3/CALML4	-0.504328612279273
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1974	18/9376	0.791624451198919	CBR4/ACACB/MECR	-0.456957869315979
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1974	18/9376	0.791624451198919	PRDX1/MMAB/MMAA	-0.456957869315979
Organismal Systems	Digestive system	hsa04978	Mineral absorption	11/1974	61/9376	0.856511701297191	FTL/SLC40A1/ATOX1/ATP1B3/ATP1B1/FTH1/ATP2B1/SLC39A4/ATP7A/SLC46A1/ATP7B	-0.580596811153528
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	39/1974	203/9376	0.912512914189887	SPP1/LAMA2/CCND2/COL1A2/HGF/COL1A1/VTN/COL6A1/MYL12B/PDGFC/LAMA4/IGF1/PPP1CA/MYL12A/CDC42/GRB2/CCND1/PRKCB/COL6A2/JUN/VAV1/SHC1/VEGFB/TNXB/BAD/HRAS/LAMA5/ITGB5/PPP1CC/PIK3CD/MAPK10/VAV3/PARVB/RAC2/COL4A4/PAK1/PIK3R3/PIK3R2/ITGA4	-0.650760141083143
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	25/1974	134/9376	0.886146773730134	CALM1/CALM2/CALM3/PLCB1/GUCY1A2/MYL6/ITPR1/MAP2K2/ITPR2/PPP1R14A/PPP1CA/GNAS/MYH10/GUCY1A1/PRKCB/PRKG1/CALML4/PRKACB/PPP1CC/PRKACA/RAMP2/PLCB2/ADCY7/AGTR1/MYL6B	-0.685487328107231
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	18/1974	99/9376	0.863590310398821	LAMA2/RYR2/TPM3/SGCE/IGF1/EMD/SGCB/SGCA/SNTA1/CACNB4/ITGB5/CACNA2D4/TNF/TTN/DTNA/TGFB3/MYL3/ITGA4	-0.704601740571707
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	17/1974	94/9376	0.858996744917976	CCL2/S100A9/CXCL8/SRSF1/HSP90B1/JUN/TRADD/MMP1/TNF/MAPK7/MAPK10/IKBKG/IL17RC/CHUK/MAPK13/TRAF3/TRAF2	-0.709507442252101
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	16/1974	89/9376	0.853887048484227	SPP1/LAMA2/COL1A2/COL1A1/CD36/VTN/COL6A1/LAMA4/FREM1/COL6A2/CD47/TNXB/LAMA5/ITGB5/COL4A4/ITGA4	-0.715205204660567
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	6/1974	36/9376	0.791624451198919	AKR1B1/AKR1A1/GUSB/CRYL1/RPE/KL	-0.646858427851652
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/1974	31/9376	0.766088178579599	AKR1A1/ALDH9A1/GUSB/ALDH7A1/KL	-0.673640263026133
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1974	37/9376	0.770229195761111	MIF/COMT/ADH5/GSTZ1/GOT1/GOT2	-0.723152997437639
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1974	20/9376	0.712462006079027	NPL/NANS/GMPPA	-0.664736921850045
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1974	14/9376	0.678535243884788	B4GALT4/ST3GAL2	-0.621581009263202
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/1974	49/9376	0.775468850154043	ST6GAL1/GALNT11/COLGALT1/C1GALT1/GXYLT2/GALNT10/B3GLCT/XXYLT1	-0.813744983057112
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	42/1974	226/9376	0.882696290717379	RYR2/CALM1/CALM2/GNAI2/CALM3/PDE4D/ATP1B3/ATP1B1/MAP2K2/ATP2B1/PPP1CA/PLD1/GNAS/BDNF/GLI3/JUN/VAV1/CREB1/PDE3B/BAD/FXYD1/CALML4/PRKACB/PPP1CC/PTCH1/GRIA4/PRKACA/PIK3CD/MAPK10/ADCY7/VAV3/GRIN2C/RAC2/ORAI1/PAK1/PIK3R3/CFTR/PIK3R2/TSHR/ADRB1/ACOX3/PLD2	-0.921807186846428
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	29/1974	160/9376	0.860891590678825	HLA-C/CADM3/PTPRD/VCAN/VCAM1/CD86/PTPRC/NRCAM/GLG1/CD28/CD4/SIGLEC1/ALCAM/PECAM1/ICAM1/PTPRS/HLA-DPA1/ITGAM/CDH5/CLDN23/SELPLG/LRRC4/NCAM2/HLA-DQA2/HLA-DMA/CD276/ITGA4/ICAM2/CD40	-0.916488067371287
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	9/1974	55/9376	0.777231279358939	ASAH1/NEU1/CERS2/ACER3/PLPP3/GLB1/GLA/SMPD1/CERK	-0.855635851607633
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	16/1974	93/9376	0.817160723818239	IL12RB2/CD4/RBPJ/PPP3R1/JUN/NFATC3/HLA-DPA1/JAK3/MAPK10/HLA-DQA2/IKBKG/HLA-DMA/CHUK/MAPK13/IL2RA/NOTCH3	-0.915063988413971
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1974	15/9376	0.633299560959135	GLB1/ST3GAL2	-0.733973886612984
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	7/1974	45/9376	0.738849487785658	ABCC5/ABCA10/ABCC3/ABCG2/CFTR/ABCB8/TAP2	-0.906812955397204
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	7/1974	45/9376	0.738849487785658	HLA-C/CD86/CD28/HLA-DPA1/TNF/HLA-DQA2/HLA-DMA	-0.906812955397204
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/1974	34/9376	0.698492162822576	RBX1/BHLHE41/CREB1/PER3/DBP	-0.909500211500813
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/1974	52/9376	0.730730262645156	IGF1/GNAS/PRKACB/HSD17B1/PRKACA/ALOX5/HSD3B2/ADCY7	-1.00547842947319
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	17/1974	102/9376	0.791624451198919	RYR2/PLCB1/ATP1B3/ATP1B1/ITPR1/ITPR2/ATP2B1/GNAS/RAB11A/PRKCB/RAB8A/KCNQ1/PLCB2/ADCY7/CFTR/BST1/CPA1	-1.0926925164715
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1974	23/9376	0.619532179199154	ATP1B3/ATP1B1/MDH1	-0.943389533733078
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	42/1974	233/9376	0.856177518034883	COL3A1/LAMA2/DCN/COL1A2/COL1A1/COL5A2/NEBL/COL5A1/TPM3/COL6A1/VCAN/CAPZB/ATP1B3/SGCE/CAPZA2/ATP1B1/MYH10/CSRP2/FHL2/ELN/TNNT3/EMD/COL6A2/ANK2/SGCB/SGCA/SYNE1/SNTA1/ANK3/PDLIM2/ITGB5/TNNT1/FMNL1/LBR/TTN/DTNA/COL4A4/NID2/ANKRD23/MYL3/ITGA4/AMPD2	-1.14800836290074
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	14/1974	86/9376	0.773214580240805	RYR2/PLCB1/ATP1B3/ATP1B1/GNAS/PRKCB/CREB1/VAMP2/PRKACB/PRKACA/PLCB2/ADCY7/SLC2A1/GCK	-1.09104124968286
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	11/1974	70/9376	0.746388768273267	HPGDS/GSTP1/MGST3/MGST2/GSTO1/SULT1A1/GSTK1/CYP1A2/GSTA4/CBR1/SULT1A2	-1.09981756440514
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/1974	17/9376	0.558793730258061	SCP2/HSD17B4	-0.940234287122301
NA	NA	hsa03272	Virion - Hepatitis viruses	7/1974	48/9376	0.692671394799054	CD63/CD81/TGOLN2/CHMP4A/CD9/VPS4A/CLDN23	-1.10233604086523
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	8/1974	54/9376	0.703666178843484	RPA3/CENPX/ATR/TELO2/PMS2/MUS81/ERCC4/RMI1	-1.12773802393618
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	8/1974	54/9376	0.703666178843484	HLA-C/CD86/CD28/HLA-DPA1/HLA-DQA2/HLA-DMA/TSHR/CD40	-1.12773802393618
Human Diseases	Substance dependence	hsa05034	Alcoholism	33/1974	191/9376	0.820636865640764	GNGT1/GNG10/CALM1/CALM2/GNG5/GNG2/GNAI2/GNG11/CALM3/PPP1CA/GNB2/GNAS/HDAC9/GRB2/HDAC8/BDNF/HAT1/CREB1/SHC1/GNB4/CALML4/GNG7/HRAS/PRKACB/HDAC2/PPP1CC/HDAC3/HDAC1/PRKACA/KRAS/GRIN2C/NRAS/SLC29A3	-1.29328714224692
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	9/1974	62/9376	0.68947936072164	RBPJ/DVL3/HDAC2/CTBP1/PSENEN/HDAC1/DTX4/DTX3L/NOTCH3	-1.26678488121242
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/1974	86/9376	0.717984967366462	LAMA2/RYR2/SGCE/EMD/SGCB/SGCA/SNTA1/CACNB4/ITGB5/CACNA2D4/DTNA/TCF7/ITGA4	-1.35674521739783
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/1974	47/9376	0.606350643471513	PIK3CD/TNF/MAPK10/PIK3R3/PIK3R2/GCK	-1.39709391237593
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1974	28/9376	0.508901432913591	ST3GAL4/B3GNT5/B4GALT4	-1.34391871786977
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1974	13/9376	0.365365131322578	POLL	-1.18242272070188
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	36/1974	217/9376	0.787976412253302	GNAI2/FGF7/MGST3/MAP2K2/RB1/GNAS/MGST2/GRB2/GSTO1/FGF10/CCND1/HSP90B1/PRKCB/JUN/CREB1/ARRB2/AIP/CYP1A2/BAD/HRAS/PRKACB/RPS6KB2/PRKACA/KRAS/PIK3CD/ARRB1/ADCY7/PAQR7/NRAS/GSTA4/KPNA2/PIK3R3/PIK3R2/RPS6KA1/ADRB1/PAQR8	-1.63182915637497
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	11/1974	79/9376	0.661357136444667	HPGDS/GSTP1/MGST3/MGST2/ADH5/GSTO1/AKR7A2/GSTK1/CYP1A2/GSTA4/CBR1	-1.56087717544905
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1974	36/9376	0.527749634132613	GALNT11/C1GALT1/GALNT10/ST3GAL2	-1.46600275788097
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1974	30/9376	0.474974670719352	CYP1A2/PLAAT3/PLB1	-1.48734825061209
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/1974	37/9376	0.513486130507407	RIMKLB/NIT2/GOT1/GOT2	-1.53119524555768
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	18/1974	122/9376	0.700782301061338	CD36/IGF1/CCND1/RAB14/CREB1/ACACB/RAB8A/PFKL/RPS6KB2/PIK3CD/CPT1A/TSC2/PFKFB2/SCD5/G6PC3/PIK3R3/CFTR/PIK3R2	-1.71785743354439
NA	NA	hsa04081	Hormone signaling	35/1974	219/9376	0.759091939505813	SLC40A1/GNGT1/GNG10/SLC16A10/GNG5/GNG2/GNAI2/GNG11/PLCB1/CSH1/IGF1/GNB2/GNAS/GNA14/APPL1/SMAD5/PRKG1/BMPR1A/GNB4/GNG7/PRKACB/GNA15/THRA/PRKACA/PIK3CD/RAMP2/PLCB2/ADCY7/EPOR/PIK3R3/PIK3R2/TSHR/ADRB1/AGTR1/ADRA2A	-1.86286530191142
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/1974	66/9376	0.575726873599214	IL12RB2/JUN/HLA-DPA1/TLR4/TNF/HLA-DQA2/HLA-DMA/TGFB3	-1.78618864240571
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	21/1974	143/9376	0.69751525070674	C1QA/FCGR3A/C1QB/C1QC/C1R/SSB/CD86/SNRPD3/FCGR2A/SNRPD1/SNRPB/C2/FCGR1A/CD28/ELANE/C6/HLA-DPA1/TNF/HLA-DQA2/HLA-DMA/CD40	-1.8822822904581
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	15/1974	109/9376	0.65363486796241	RUNX1/HIF1A/CD4/PPP3R1/JUN/NFATC3/HLA-DPA1/JAK3/MAPK10/HLA-DQA2/IKBKG/HLA-DMA/CHUK/MAPK13/IL2RA	-1.8782893902207
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	9/1974	73/9376	0.585585210475913	HPGDS/GSTP1/MGST3/MGST2/ADH5/GSTO1/GSTK1/CYP1A2/GSTA4	-1.83556529358646
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1974	17/9376	0.27939686512903	CSAD	-1.5356440315542
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1974	17/9376	0.27939686512903	CA1	-1.5356440315542
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/1974	26/9376	0.365365131322578	HHEX/GCK	-1.67336033504173
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1974	26/9376	0.365365131322578	PLB1/SLC46A1	-1.67336033504173
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	27/1974	183/9376	0.700782301061338	NOP10/RAN/SNU13/RPP25/CSNK2B/XPO1/EIF6/NOP56/NMD3/MPHOSPH10/IMP3/RRP7A/NHP2/FBL/DROSHA/POP7/RPP30/RPP38/RPP25L/RIOK2/GAR1/WDR36/POP4/NOB1/NOL6/UTP14A/TBL3	-2.11090586024083
NA	NA	hsa04082	Neuroactive ligand signaling	29/1974	199/9376	0.692174143259357	GNGT1/GNG10/GNG5/GNG2/GNAI2/GNG11/PLCB1/GNB2/GNAS/OGFRL1/HRH2/HRH1/PRKCB/GNB4/OGFR/GNG7/PRKACB/GRIA4/PRKACA/PLCB2/ADCY7/GRIN2C/P2RY13/GABRA3/ADRB1/SLC1A1/HTR2C/ADRA2A/SLC1A2	-2.26655332547192
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	46/1974	298/9376	0.733182377620476	CXCL14/CCL3/CCL2/BMP5/CCL4/CCL4L2/CCL3L1/BMP4/CSH1/CSF1R/IL12RB2/CXCL8/EDA/ACVR2A/TNFRSF1A/CCR1/CD4/CSF1/TNFRSF1B/CCL8/BMP7/BMPR1A/TNFSF13B/TNFRSF10B/IL10RA/CXCL16/IFNAR2/TNFRSF11A/CCL13/TNFSF12/TNF/CX3CR1/EPOR/ACVRL1/IL17RC/TNFRSF25/GDF6/TGFB3/IL2RA/CTF1/TNFRSF14/CD40/CNTFR/IL1RN/CCL28/RELT	-2.41719799120619
Organismal Systems	Digestive system	hsa04976	Bile secretion	10/1974	90/9376	0.527749634132613	ATP1B3/ATP1B1/GNAS/PRKACB/ABCC3/PRKACA/ADCY7/SLC2A1/ABCG2/CFTR	-2.32468380501967
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1974	41/9376	0.347542441989769	GRIA4/GRIN2C/GABRA3	-2.1620797316939
NA	NA	hsa04519	Cadherin signaling	64/1974	404/9376	0.752435121931646	WNT2/ARPC3/PRICKLE1/ARPC1B/BRK1/YWHAB/ARPC2/ARPC5/ACTR2/FZD4/MAP2K2/PCDH10/PPP1CA/ABI2/CDC42/NCKAP1L/EVL/CYFIP1/KRT10/MYO1B/MOB1A/ARPC4/VAV1/ARPC1A/SCN1B/LHFPL6/YWHAH/PCDH12/APC/DVL3/HRAS/PCDH18/LRP6/AXIN2/ARPC5L/PPP1CC/PSENEN/NF2/WNT5B/CDH5/KRAS/MAPK10/KRT1/MYO1F/TMC6/VAV3/LATS1/TMC8/TAOK2/NRAS/IKBKG/RAC2/FAT4/MOB1B/CHUK/MAPK13/TCF7/GABRA3/PCDHGA10/LIMD1/MYO7A/WNT10A/WNT11/PCDHB14	-2.62675612506766
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1974	66/9376	0.431795155199411	COMT/CYP1A2/HSD17B12/HSD17B1/HSD3B2/SRD5A3	-2.39214076307999
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/1974	68/9376	0.419095297693546	ADH5/CYP1A2/RDH11/DHRS4L2/PNPLA4/DGAT1	-2.4826519168422
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	21/1974	168/9376	0.593718338399189	CCND2/CSH1/IL12RB2/PTPN2/GRB2/CCND1/PIAS2/HRAS/STAT2/IL10RA/IFNAR2/PTPN6/IRF9/JAK3/PIK3CD/EPOR/PIK3R3/PIK3R2/IL2RA/CTF1/CNTFR	-2.74399854966793
Organismal Systems	Sensory system	hsa04742	Taste transduction	6/1974	86/9376	0.331377677246059	PLCB1/SCN9A/PRKACB/PRKACA/PLCB2/GABRA3	-3.21667299140265
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	39/1974	323/9376	0.573498828422746	CCND2/MARCKS/ZEB2/CDK6/FSCN1/MAP2K2/GRB2/UBE2I/CCNG1/CCND1/ATM/PRKCB/CDKN2A/STMN1/SHC1/DNMT3A/TNXB/APC/HRAS/CDKN1B/HDAC2/PLAU/HDAC1/KRAS/PIK3CD/MAPK7/BCL2L2/E2F3/NRAS/CDC25B/TP53/PIK3R3/PIK3R2/RASSF1/FGFR3/NOTCH3/CCNE1/SPRY2/BAK1	-4.02818957770248
NA	NA	hsa04382	Cornified envelope formation	16/1974	217/9376	0.350211738779245	S100A9/S100A10/S100A6/S100A4/S100A11/KRT10/SLC27A4/LAMA5/CAPN1/CLDN23/KRT1/COL4A4/BLMH/ELOVL1/S100A16/COL7A1	-5.00106352033343
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	26/1974	370/9376	0.333765984829815	SPX/CSH1/TSPO/C3AR1/OGFRL1/LPAR6/HRH2/HRH1/OGFR/FPR1/KISS1/CYSLTR1/THRA/GRIA4/PTGER4/PTGFR/PTAFR/GRIN2C/APLNR/P2RY13/TSHR/GABRA3/ADRB1/HTR2C/AGTR1/ADRA2A	-6.75221659418339
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	14/1974	449/9376	0.148099006460377	CALM1/CALM2/CALM3/PRKG1/ARRB2/CALML4/GRK2/GRK3/GNG7/PRKACB/NCALD/PRKACA/ARRB1/OR3A2	-9.55309727167969