category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	37/299	238/9376	4.87496135577977	F13A1/C1QA/C1QB/C1QC/CYBB/CCL2/C7/NRP1/RPS11/RPL23/RPL27A/RPL37A/CFD/FOS/RPS23/FCGR2A/SYK/IL6ST/RPL37/RPS24/RPL7/C2/RPL21/C3AR1/RPL15/RPL38/RPL22/RPL27/TLR7/RPL29/TLR2/MMP1/RPS6/RPL13A/UBA52/RPL26/RPS17	10.9895609501763
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	15/299	88/9376	5.34508969291578	F13A1/C1QA/C1QB/C1QC/SERPINE2/C7/CR1/VSIG4/VTN/CFD/F3/C2/C3AR1/PROS1/C4BPB	7.43239945979721
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	11/299	50/9376	6.89872909698997	HBA2/HBA1/HBB/CD36/HGF/CCL2/CR1/LRP1/GYPB/GYPA/TLR2	7.59007054855885
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	21/299	204/9376	3.22801495180012	DCN/GPC3/HGF/LUM/COL1A1/WNT2/FN1/CD63/VTN/IGF2/ITPR2/CTSL/TWIST1/ACTB/FZD2/COL1A2/ANK2/TLR2/TIMP3/RPS6/CCND1	5.83917143781921
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	20/299	205/9376	3.05930336895342	CD36/COL3A1/MT-ATP6/CYBB/MT-ND1/MT-CYB/MT-ND3/MT-CO3/MT-CO2/COL1A1/PDK4/MT-ND5/MT-ND2/MT-CO1/MT-ND4/MT-ND4L/COL1A2/RYR2/MT-ND6/NCF2	5.41051964723585
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	28/299	362/9376	2.42546979803766	SPP1/HGF/COL1A1/LAMA2/CSF1R/PRLR/PDGFC/FN1/CSH1/VTN/IGF2/GNGT1/SYK/LAMC1/GNG10/COL6A1/TCL1A/FGF10/COL1A2/COL6A2/PDGFRA/TLR2/EFNA5/RPS6/GNG11/CCND1/FGF7/KITLG	5.01999856757282
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	23/299	275/9376	2.62265734265734	C1QA/C1QB/C1QC/MT-ATP6/CYBB/MT-ND1/MT-CYB/C7/MT-ND3/MT-CO3/MT-CO2/MT-ND5/MT-ND2/EGR1/MT-CO1/MT-ND4/ITPR2/LAMC1/MT-ND4L/RYR2/MT-ND6/TUBA1B/NCF2	4.9567689283643
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	16/299	155/9376	3.23694033876362	CD14/CD36/FCGR3A/MRC1/CYBB/COLEC12/FCGR1A/CD209/FCGR2A/CLEC7A/CTSL/ACTB/MSR1/TLR2/TUBA1B/NCF2	5.09660884898761
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	20/299	233/9376	2.69166176238391	DCN/COL3A1/COL1A1/LAMA2/FN1/COL11A1/VCAN/FBLN1/NEBL/COL6A1/FMNL2/ACTB/TNNT3/TNNT2/COL1A2/COL6A2/DTNA/TNNT1/ANK2/CSRP2	4.74566631435128
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	12/299	99/9376	3.80095267051789	C1QA/C1QB/C1QC/FCGR3A/FCGR1A/CFD/FCGR2A/KRT19/KRT18/C2/C3AR1/FPR1	5.08475057351934
Genetic Information Processing	Translation	hsa03010	Ribosome	19/299	222/9376	2.68378077073729	RPS11/RPL23/RPL27A/RPL37A/RPS23/RPL37/RPS24/RPL7/RPL21/RPL15/RPL38/RPL22/RPL27/RPL29/RPS6/RPL13A/UBA52/RPL26/RPS17	4.60793817250526
NA	NA	hsa04518	Integrin signaling	15/299	154/9376	3.05433696738045	SPP1/HGF/COL1A1/LAMA2/PDGFC/FN1/VTN/LAMC1/COL6A1/FREM1/ACTB/COL1A2/COL6A2/PDGFRA/CCND1	4.66519227031643
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/299	89/9376	3.87569050392695	SPP1/CD36/COL1A1/LAMA2/FN1/VTN/LAMC1/COL6A1/FREM1/COL1A2/COL6A2	4.94708632231466
NA	NA	hsa04517	IgSF CAM signaling	22/299	299/9376	2.30726725651838	SLIT2/MTSS1/NRP1/PMP22/CADM3/LYN/CD209/PTPRD/ROBO2/CD86/ROBO1/ACTB/UNC5C/NRP2/NFASC/ANK2/SRGAP1/IL1RAPL1/CADM2/TUBA1B/EPB41L3/CLMP	4.1694510018394
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	11/299	103/9376	3.34889761989804	COL3A1/COL1A1/COL15A1/SLC8A1/COL14A1/COL11A1/SLC16A10/COL6A1/COL1A2/COL6A2/KCNE3	4.35033433490309
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	17/299	227/9376	2.34838595612394	MT-ATP6/HGF/MT-ND1/MT-CYB/MT-ND3/MT-CO3/MT-CO2/MT-ND5/MT-ND2/MT-CO1/MT-ND4/FOS/PLD1/MT-ND4L/MT-ND6/MGST2/NCF2	3.7324190725491
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/299	98/9376	3.19978158487475	FCGR3A/MARCKS/PLPP3/LYN/FCGR1A/FCGR2A/SYK/PLD1/SCIN/HCK	3.97297178199347
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	12/299	138/9376	2.72677039406718	MT-ATP6/MT-ND1/MT-CYB/MT-ND3/MT-CO3/MT-CO2/MT-ND5/MT-ND2/MT-CO1/MT-ND4/MT-ND4L/MT-ND6	3.70881544478966
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/299	140/9376	2.68781653129479	SPP1/MEF2C/SLC8A1/EGR1/ITPR2/GNGT1/GNG10/KLF2/RYR2/RPS6/GNG11/CCND1	3.65171904587277
Organismal Systems	Immune system	hsa04611	Platelet activation	11/299	126/9376	2.73759091150395	COL3A1/FCER1G/COL1A1/LYN/PRKG1/ITPR2/FCGR2A/SYK/ACTB/COL1A2/TBXAS1	3.56378919820417
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	12/299	149/9376	2.52546519718974	MT-ND1/MT-ND3/MT-ND5/MT-ND2/MT-ND4/ITPR2/GNGT1/GNG10/MT-ND4L/GRIA4/MT-ND6/GNG11	3.406553723254
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/299	78/9376	3.21619072120744	C1QA/CD14/C1QB/C1QC/LY96/FOS/C2/C4BPB	3.56705435579604
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/299	78/9376	3.21619072120744	FCGR3A/CYBB/CR1/FCGR1A/FOS/FCGR2A/TLR2/NCF2	3.56705435579604
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	14/299	195/9376	2.25133350484521	FCGR3A/CYBB/CR1/FCGR1A/FCGR2A/SYK/CLEC7A/HDAC9/ACTB/CLCN5/TLR7/FPR1/TLR2/NCF2	3.20475954507607
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	9/299	101/9376	2.79426471075201	COL3A1/CYBB/CCL2/COL1A1/FN1/EGR1/F3/COL1A2/CCND1	3.29033644563365
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/299	51/9376	3.68915994491442	ENPP2/PLPP3/PLA2G2A/PLD1/PLD4/LPCAT2	3.49484055117354
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	14/299	203/9376	2.16261100219121	SPP1/HGF/COL1A1/LAMA2/PDGFC/FN1/VTN/LAMC1/COL6A1/ACTB/COL1A2/COL6A2/PDGFRA/CCND1	3.03932271140175
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	11/299	142/9376	2.42912996372886	FCGR3A/TYROBP/CSF1R/FCGR1A/ITPR2/FOS/SPI1/FCGR2A/SYK/LILRB5/NCF2	3.11437587577248
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/299	52/9376	3.61821456135837	PLTP/CD36/NPC2/LRP1/APOE/ABCA1	3.43602122520625
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	9/299	109/9376	2.58918106225645	SPP1/CD14/LY96/CCL3/FOS/CD86/TLR7/TLR2/TLR5	3.0287757062764
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	15/299	235/9376	2.00156550202804	MT-ATP6/MT-ND1/MT-CYB/MT-ND3/MT-CO3/MT-CO2/MT-ND5/MT-ND2/MT-CO1/PRKG1/MT-ND4/ACTB/MT-ND4L/MT-ND6/RPS6	2.82206166016871
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	15/299	238/9376	1.97633568477558	HGF/CSF1R/PDGFC/RGL1/IGF2/GNGT1/GNG10/PLA2G2A/PLD1/FGF10/PDGFRA/EFNA5/GNG11/FGF7/KITLG	2.7689309726069
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	13/299	196/9376	2.07985803016859	LYN/ITPR2/FOS/GNGT1/SYK/CD86/IL6ST/GNG10/HCK/LEF1/GNG11/UBA52/CCND1	2.77283113491416
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/299	42/9376	3.73307851568721	FTL/CYBB/SLC40A1/FTH1/NCOA4	3.22175803131718
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	16/299	268/9376	1.87211101682224	MT-ATP6/MT-ND1/MT-CYB/MT-ND3/MT-CO3/MT-CO2/MT-ND5/MT-ND2/MT-CO1/MT-ND4/ITPR2/SNCA/MT-ND4L/MT-ND6/UBA52/TUBA1B	2.6289221366404
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/299	97/9376	2.58621521911526	PRKG1/FOS/GNGT1/GNG10/RYR2/GRIA4/NOS1AP/GNG11	2.85001704153552
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	13/299	201/9376	2.0281202682241	CD14/IGFBP3/MEF2C/CSF1R/FCGR1A/SPI1/MAF/CD86/PROM1/BMP2K/ETV5/LYL1/PAX5	2.67416978664951
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/299	103/9376	2.43556190538039	CD14/COL3A1/COL1A1/LAMA2/FN1/LAMC1/COL1A2/TLR2	2.65876817871964
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/299	86/9376	2.55238391537684	LAMA2/SLC8A1/GJA1/ACTB/LEF1/DTNA/RYR2	2.62476585350371
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/299	87/9376	2.52304616922308	MT-CYB/MT-CO3/MT-CO2/SLC8A1/MT-CO1/TNNT2/RYR2	2.59022969626507
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/299	68/9376	2.76686995868582	CD14/CSF1R/FCGR1A/SPI1/LEF1/CCND1	2.65387779286103
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	9/299	130/9376	2.17092873681502	COL3A1/COL1A1/FOS/GNGT1/GNG10/COL1A2/EDNRB/MMP1/GNG11	2.43991816760997
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	20/299	388/9376	1.61638451194704	MT-ATP6/CYBB/MT-ND1/MT-CYB/MT-ND3/MT-CO3/MT-CO2/WNT2/MT-ND5/MT-ND2/MT-CO1/MT-ND4/ITPR2/LRP1/APOE/SNCA/MT-ND4L/FZD2/MT-ND6/TUBA1B	2.25053677072598
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/299	73/9376	2.57735831767994	HGF/PDGFC/FGF10/PDGFRA/CCND1/FGF7	2.45544575609413
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	14/299	250/9376	1.75604013377926	LGMN/NPC2/CD68/CD63/CTSL/CTSC/ASAH1/FUCA1/CTSZ/DMXL2/TLR7/CTSB/OSBPL6/PSAP	2.19899725403147
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	11/299	181/9376	1.90572626988673	CD14/FCER1G/FCGR3A/MRC1/CR1/FCGR1A/CD209/FCGR2A/SYK/CLEC7A/TLR2	2.23311171341902
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/299	95/9376	2.31057912339377	CCL2/CCL3/FOS/CD86/CTSL/TLR2/MMP1	2.33011699043775
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/299	116/9376	2.16261100219121	ITPR2/GNGT1/GNG10/PLD1/GRK3/GRIA4/GLUL/GNG11	2.28669369566431
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	9/299	142/9376	1.98746997032361	MEF2C/CCL2/FOS/BMP4/CTSL/ACTB/KLF2/MGST2/NCF2	2.15190551711719
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/299	10/9376	6.27157190635451	SELENBP1/PAPSS2	3.02700489153272
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	9/299	143/9376	1.97357157892275	C1QA/C1QB/C1QC/FCGR3A/C7/FCGR1A/FCGR2A/CD86/C2	2.12919066199749
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/299	100/9376	2.19505016722408	CD14/CD36/CR1/CSF1R/FCGR1A/GYPA/KITLG	2.18049869780565
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	9/299	144/9376	1.95986622073579	C1QA/CD14/C1QB/C1QC/LY96/C2/C3AR1/LEF1/CCND1	2.10665840885219
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	12/299	216/9376	1.7421033073207	CD14/CD36/CYBB/CCL2/LY96/CCL3/LYN/FOS/ABCA1/TLR2/MMP1/NCF2	2.002597042676
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	7/299	103/9376	2.13111666720784	C1QA/C1QB/C1QC/CCL2/CCL3/FOS/TLR2	2.09491279332516
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/299	43/9376	2.9170101890021	CD36/PLPP3/PLA2G2A/ABCA1	2.28664149740042
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/299	46/9376	2.72677039406718	FTL/BLVRB/FTH1/ALAS2	2.13070219148789
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	9/299	157/9376	1.79758430436913	C1QA/CD36/C1QB/C1QC/STAB1/LRP1/GAS6/PROS1/ABCA1	1.82908792326811
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/299	89/9376	2.11401300214197	PDGFC/PRKG1/ITPR2/GJA1/PDGFRA/TUBA1B	1.91645049362977
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	10/299	184/9376	1.70423149629199	SLIT2/NRP1/EPHA3/ROBO2/ROBO1/EPHA7/UNC5C/SRGAP1/SEMA6D/EFNA5	1.75093253644496
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	8/299	137/9376	1.83111588506701	ITPR2/FOS/CTSL/CTSC/ACTB/CTSZ/CTSB/TUBA1B	1.77852284359537
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	5/299	70/9376	2.23984710941233	LAMA2/CD86/ACTB/DTNA/CCND1	1.88966880795056
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/299	115/9376	1.90873927584703	MEF2C/EGR1/ITPR2/FOS/PLD1/MAFB/CYP24A1	1.77954650300349
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	11/299	212/9376	1.62705874929009	HGF/CSF1R/PDGFC/FGF10/ACTB/DOCK4/PDGFRA/FPR1/EFNA5/FGF7/KITLG	1.6760373276664
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	21/299	480/9376	1.37190635451505	MT-ATP6/CYBB/MT-ND1/MT-CYB/MT-ND3/MT-CO3/MT-CO2/WNT2/MT-ND5/MT-ND2/MT-CO1/MT-ND4/ITPR2/SNCA/MT-ND4L/FZD2/RYR2/GRIA4/MT-ND6/UBA52/TUBA1B	1.51812277322897
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	10/299	193/9376	1.62475956123174	CXCL14/CCL2/CCL3/LYN/GNGT1/GNG10/CCL8/HCK/GRK3/GNG11	1.59165646720492
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/299	99/9376	1.90047633525894	LAMA2/SLC8A1/ACTB/TNNT2/DTNA/RYR2	1.63469294227736
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/299	100/9376	1.88147157190635	CXCL14/CCL2/CSF1R/CCL3/IL6ST/CCL8	1.60834052612129
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/299	17/9376	3.68915994491442	PAPSS2/INMT	2.01407869498276
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/299	17/9376	3.68915994491442	CA8/GLUL	2.01407869498276
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/299	17/9376	3.68915994491442	CD209/NRP2	2.01407869498276
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/299	56/9376	2.23984710941233	CD14/CR1/TLR2/TLR5	1.68890124487403
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	5/299	80/9376	1.95986622073579	HGF/PDGFC/GAS6/PDGFRA/RPS6	1.5647959342057
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/299	37/9376	2.5425291512248	HBA2/HBA1/HBB	1.70621642810981
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/299	37/9376	2.5425291512248	NCOA4/LEF1/CCND1	1.70621642810981
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	14/299	308/9376	1.42535725144421	MT-ATP6/MT-ND1/MT-CYB/MT-ND3/MT-CO3/MT-CO2/MT-ND5/MT-ND2/MT-CO1/MT-ND4/MT-ND4L/GRIA4/MT-ND6/TUBA1B	1.37760118654049
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	9/299	178/9376	1.58550975160648	WNT2/RSPO2/SERPINF1/LEF1/RSPO3/FZD2/FRZB/PRICKLE1/CCND1	1.43135544939836
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/299	105/9376	1.79187768752986	LAMA2/SLC8A1/ACTB/TNNT2/DTNA/RYR2	1.48094704602916
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	6/299	106/9376	1.77497318104373	FOLR2/PDGFC/LEF1/ETV5/PDGFRA/CCND1	1.45629649292596
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/299	61/9376	2.05625308405066	FTL/SLC40A1/SLC8A1/FTH1	1.50207473923829
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/299	63/9376	1.99097520836651	PTGDS/HPGDS/PLA2G2A/TBXAS1	1.43231429905596
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/299	63/9376	1.99097520836651	WNT2/BMP4/LEF1/FZD2	1.43231429905596
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/299	41/9376	2.29447752671507	DAPK1/MMP1/CCND1	1.50757645791316
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/299	22/9376	2.85071450288842	HNMT/AOC1	1.57725586331737
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	13/299	298/9376	1.36796031514444	CXCL14/BMP5/CCL2/CSF1R/PRLR/CCL3/CSH1/EDA/BMP4/IL6ST/CCL8/CNTFR/EBI3	1.17155879756146
NA	NA	hsa04081	Hormone signaling	10/299	219/9376	1.43186573204441	PRLR/SLC40A1/CSH1/PRKG1/SLC16A10/IGF2/GNGT1/CGA/GNG10/GNG11	1.17366528667034
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/299	91/9376	1.72295931493256	LYN/FOS/SYK/LILRB5/CD79A	1.25774808426113
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/299	91/9376	1.72295931493256	GNGT1/GNG10/PDE3A/GRK3/GNG11	1.25774808426113
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	5/299	93/9376	1.68590642643939	LAMA2/FN1/LAMC1/FHIT/CCND1	1.20645807784249
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	8/299	170/9376	1.47566397796577	HGF/WNT2/IGF2/ACTB/LEF1/FZD2/MGST2/CCND1	1.1358979181853
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	14/299	333/9376	1.31834844878323	SPP1/COL1A1/LAMA2/WNT2/FN1/RBPJ/VTN/LAMC1/COL6A1/FZD2/COL1A2/COL6A2/MAML2/CCND1	1.07354104597829
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/299	71/9376	1.76663997362099	PRLR/FOS/CGA/CCND1	1.17682669268449
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	7/299	148/9376	1.48314200488114	WNT2/FOS/FGF10/LEF1/FZD2/CCND1/FGF7	1.07523137019613
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	7/299	149/9376	1.47318803169401	FCER1G/PDGFC/PLPP3/SYK/PLD1/PDGFRA/KITLG	1.05668779211485
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/299	150/9376	1.46336677814939	HGF/WNT2/FGF10/LEF1/FZD2/CCND1/FGF7	1.03827850267682
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	10/299	232/9376	1.35163187636951	C7/PDGFC/FN1/SCIN/FGF10/ACTB/CYFIP1/TMSB4X/PDGFRA/FGF7	0.984269860117881
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/299	99/9376	1.58373027938245	PDGFC/PLPP3/FOS/PLD1/PDGFRA	1.05968333707036
NA	NA	hsa04519	Cadherin signaling	16/299	404/9376	1.24189542700089	WNT2/CDH11/KRT19/KRT18/PCDH12/PCDH10/GJA1/ACTB/CYFIP1/LEF1/KRT8/FZD2/PDGFRA/PRICKLE1/KRT7/SCN1B	0.902035797377895
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/299	101/9376	1.55236928375112	WNT2/LEF1/FZD2/EDNRB/KITLG	1.01293904677706
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/299	154/9376	1.42535725144421	MEF2C/ITPR2/FOS/ACTB/RYR2/TRPM2/CCND1	0.965943461598173
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	7/299	157/9376	1.39812112562043	BMP5/WNT2/BMP4/ACTB/LEF1/FZD2/CCND1	0.913005106646664
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/299	104/9376	1.50758940056599	PLPP3/PLA2G2A/PLD1/PLD4/LPCAT2	0.9446970679294
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/299	105/9376	1.49323140627488	CD14/LY96/EDA/LYN/SYK	0.92242729607665
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/299	105/9376	1.49323140627488	FCER1G/ITPR2/CD209/SYK/CLEC7A	0.92242729607665
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	12/299	300/9376	1.2543143812709	CD14/MEF2C/HGF/CSF1R/PDGFC/IGF2/FOS/FGF10/PDGFRA/EFNA5/FGF7/KITLG	0.81252057701591
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/299	133/9376	1.41464027962884	ITPR2/FOS/GNGT1/GNG10/GRIA4/GNG11	0.874059298493418
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/299	55/9376	1.71042870173305	PLPP3/ASAH1/PSAP	0.959004520381519
NA	NA	hsa04981	Folate transport and metabolism	2/299	31/9376	2.02308771172726	FOLR2/SLCO2B1	1.03550959426619
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/299	56/9376	1.67988533205925	DISP1/GRK3/CCND1	0.926129661447299
Human Diseases	Immune disease	hsa05310	Asthma	2/299	32/9376	1.95986622073579	PRG2/FCER1G	0.987118627388866
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	14/299	368/9376	1.19296204740439	MT-ATP6/MT-ND1/MT-CYB/MT-ND3/MT-CO3/MT-CO2/MT-ND5/MT-ND2/MT-CO1/MT-ND4/ACTB/MT-ND4L/MT-ND6/TUBA1B	0.685380404899775
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	10/299	254/9376	1.23456139888868	HGF/PDGFC/SLC8A1/ITPR2/FGF10/HRH1/EDNRB/PDGFRA/RYR2/FGF7	0.687825752602289
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/299	60/9376	1.56789297658863	LYN/PRKG1/ITPR2	0.800898439527424
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/299	115/9376	1.36338519703359	ITPR2/FOS/GNGT1/GNG10/GNG11	0.711602187570921
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/299	89/9376	1.40934200142798	GNGT1/GNG10/GLUL/GNG11	0.704196162155813
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/299	36/9376	1.7421033073207	ENPP1/PYGL	0.809640536558045
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/299	12/9376	2.61315496098105	CD209	1.01481311969283
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/299	38/9376	1.65041365956698	ENPP1/NAMPT	0.729129351928687
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/299	65/9376	1.44728582454335	SPP1/ITPR2/CGA	0.656740371500941
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/299	93/9376	1.34872514115151	RBPJ/FOS/MAF/MAML2	0.613381428240898
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/299	93/9376	1.34872514115151	EGR1/ITPR2/CGA/PLD1	0.613381428240898
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/299	93/9376	1.34872514115151	CST3/PRKG1/ITPR2/LYZ	0.613381428240898
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/299	66/9376	1.42535725144421	MAF/TLR2/TLR5	0.629362747267226
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/299	94/9376	1.33437700135202	S100A9/CCL2/FOS/MMP1	0.591329585396825
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/299	41/9376	1.52965168447671	ALAS2/GATM	0.616843779773782
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/299	69/9376	1.36338519703359	FCER1G/LYN/SYK	0.549840827917262
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/299	69/9376	1.36338519703359	ITPR2/PDE3A/CTSB	0.549840827917262
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/299	70/9376	1.3439082656474	HPGDS/SULT1A1/MGST2	0.524155532933647
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	7/299	187/9376	1.17382361883641	CYBB/CCL2/ITPR2/CTSB/NAMPT/CARD18/TRPM2	0.435758160962947
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/299	42/9376	1.49323140627488	AOC1/INMT	0.581422097954042
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	9/299	248/9376	1.13798683784659	CD14/LY96/FOS/ACTB/CYFIP1/LEF1/TLR2/TLR5/TUBA1B	0.39969227232716
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/299	160/9376	1.17591973244147	CADM3/SIGLEC1/VCAN/PTPRD/CD86/NFASC	0.40733654813152
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/299	44/9376	1.42535725144421	TUSC3/MAN1A1	0.513266451876174
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/299	44/9376	1.42535725144421	CD86/ICA1	0.513266451876174
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/299	73/9376	1.28867915883997	HGF/FHIT/CCND1	0.449381733688143
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/299	45/9376	1.39368264585656	ABCA1/ABCA8	0.480439269154677
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	6/299	166/9376	1.13341660958214	MEF2C/SLC8A1/PRKG1/ITPR2/PDE3A/EDNRB	0.314763375214835
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	8/299	227/9376	1.10512280288185	CCL2/CCL3/ITPR2/GNGT1/GNG10/PDGFRA/GNG11/CCND1	0.290986681264413
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/299	136/9376	1.15286248278576	FOS/CD209/TLR7/TLR2/CCND1	0.325900061419401
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/299	76/9376	1.23781024467523	PLTP/CD36/MMP1	0.37778607520661
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/299	18/9376	1.7421033073207	FUCA1	0.571951448056665
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/299	168/9376	1.11992355470616	PRLR/CSH1/IL6ST/CNTFR/PDGFRA/CCND1	0.28466006444064
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	5/299	138/9376	1.13615433086133	CCL2/FN1/FOS/FCGR2A/ACTB	0.292436844474783
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/299	110/9376	1.14028580115537	DCN/BMP5/BMP4/PITX2	0.268604927835287
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/299	50/9376	1.2543143812709	GATM/AOC1	0.327233894559462
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/299	20/9376	1.56789297658863	CYP24A1	0.461409416580453
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/299	20/9376	1.56789297658863	NPL	0.461409416580453
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/299	112/9376	1.11992355470616	LAMA2/LY96/LAMC1/TLR2	0.231720414091423
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	7/299	205/9376	1.0707561791337	RBPJ/LYN/SYK/IL6ST/SCIN/HDAC9/CCND1	0.185901554446915
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/299	144/9376	1.08881456707544	WNT2/KLF4/BMP4/IL6ST/FZD2	0.194925032797396
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/299	82/9376	1.14723876335753	LGMN/CTSL/CTSB	0.243040034382303
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/299	21/9376	1.49323140627488	ENPP1	0.410665801711107
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/299	52/9376	1.20607152045279	HSD17B2/CGA	0.270438538016135
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/299	115/9376	1.09070815762687	ITPR2/GNGT1/GNG10/GNG11	0.177630029854638
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/299	116/9376	1.08130550109561	CYBB/TXK/ACTB/NCF2	0.15991658123632
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/299	54/9376	1.16140220488047	CD86/CGA	0.215874755394821
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/299	23/9376	1.36338519703359	GLUL	0.316669143379999
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/299	87/9376	1.08130550109561	FOS/LEF1/CCND1	0.138275469032551
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/299	56/9376	1.11992355470616	TUSC3/MAN1A1	0.163358078020571
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/299	122/9376	1.02812654202533	SLC16A10/BMP4/ACTB/CCND1	0.0567520526682717
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/299	122/9376	1.02812654202533	IGFBP3/CSH1/ITPR2/FOS	0.0567520526682717
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	5/299	155/9376	1.01154385586363	WNT2/ITPR2/LEF1/FZD2/CCND1	0.0263013353223985
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	5/299	157/9376	0.998657946871738	MT-CYB/MT-CO3/MT-CO2/MT-CO1/FOS	-0.00307770997478416
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/299	59/9376	1.06297828921263	HPGDS/MGST2	0.0880701795385379
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/299	59/9376	1.06297828921263	PRKG1/CGA	0.0880701795385379
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/299	59/9376	1.06297828921263	LEF1/CCND1	0.0880701795385379
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/299	26/9376	1.20607152045279	PLA2G2A	0.190962859244176
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/299	26/9376	1.20607152045279	SLC19A3	0.190962859244176
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/299	27/9376	1.16140220488047	HMGCLL1	0.152425921781684
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/299	27/9376	1.16140220488047	ELOVL2	0.152425921781684
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/299	128/9376	0.979933110367893	ENPP1/FHIT/PDE3A/PAPSS2	-0.0414869206779252
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/299	62/9376	1.01154385586363	RBPJ/MAML2	0.0165511695693811
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/299	28/9376	1.11992355470616	ELOVL2	0.115338479435539
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/299	29/9376	1.08130550109561	RASSF4	0.0795853028046853
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/299	29/9376	1.08130550109561	GNGT1	0.0795853028046853
NA	NA	hsa04082	Neuroactive ligand signaling	6/299	199/9376	0.94546310146048	GNGT1/GNG10/TAC3/HRH1/GRIA4/GNG11	-0.14112913295404
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/299	133/9376	0.943093519752559	FCER1G/FCGR3A/TYROBP/SYK	-0.119958529473625
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	6/299	200/9376	0.940735785953177	FOS/FCGR2A/ACTB/CYFIP1/TLR5/TUBA1B	-0.153755581195933
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/299	30/9376	1.04526198439242	PLA2G2A	0.0450641718289469
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/299	30/9376	1.04526198439242	FOLR2	0.0450641718289469
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/299	168/9376	0.933269628921803	FTL/CYBB/FTH1/PYGL/GLUL	-0.158396503320887
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	5/299	169/9376	0.927747323425224	WDFY3/CTSL/DAPK1/CTSB/UBA52	-0.172023700339592
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/299	31/9376	1.01154385586363	GLUL	0.0116840163014322
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/299	102/9376	0.922289986228605	ITPR2/PLA2G2A/RYR2	-0.143216676314172
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/299	370/9376	0.932260688782428	PRLR/SPX/CSH1/LYPD6/CGA/C3AR1/TAC3/HRH1/EDNRB/FPR1/GRIA4	-0.24128244869726
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/299	69/9376	0.90892346468906	FOS/GRIA4	-0.137808578852412
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/299	139/9376	0.902384446957484	ITPR2/FOS/KRT19/KRT18	-0.210431626532768
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/299	34/9376	0.922289986228605	BHLHE41	-0.0823847024716698
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/299	109/9376	0.863060354085484	FOS/IL6ST/EBI3	-0.26098943828532
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/299	73/9376	0.859119439226646	HPGDS/MGST2	-0.219306273780517
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	6/299	214/9376	0.879192323320726	ITPR2/FOS/GNGT1/GNG10/TLR2/GNG11	-0.324456396018183
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/299	75/9376	0.836209587513935	IGFBP3/CCND1	-0.258466552890788
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/299	75/9376	0.836209587513935	ITPR2/CGA	-0.258466552890788
NA	NA	hsa04382	Cornified envelope formation	6/299	217/9376	0.867037590740256	S100A9/KRT19/KRT18/KRT8/KRT7/S100A11	-0.359653903207063
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/299	217/9376	0.867037590740256	KLF4/FOS/FGF10/MGST2/CCND1/FGF7	-0.359653903207063
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/299	37/9376	0.847509717074934	GLUL	-0.168671966845664
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/299	76/9376	0.825206829783489	ITPR2/ACTB	-0.277676959792867
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/299	76/9376	0.825206829783489	PDGFRA/CCND1	-0.277676959792867
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	9/299	323/9376	0.873748408006047	MARCKS/ZFPM2/ZEB2/PDGFRA/FSCN1/TIMP3/EFNA5/CYP24A1/CCND1	-0.41907516894453
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/299	38/9376	0.825206829783489	CD79A	-0.195947346810605
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/299	77/9376	0.814489857968119	PLD1/CCND1	-0.296650415729653
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/299	78/9376	0.804047680301861	FN1/ACTB	-0.31539369279859
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/299	39/9376	0.804047680301861	CD86	-0.222550768244469
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/299	79/9376	0.793869861563863	HPGDS/MGST2	-0.333913278536924
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	4/299	154/9376	0.814489857968119	SLC8A1/TNNT2/RYR2/SCN1B	-0.421274841671173
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/299	226/9376	0.832509545091307	FOS/CGA/PDE3A/PLD1/RYR2/GRIA4	-0.462576748724865
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/299	41/9376	0.764825842238355	GRIA4	-0.273888898365596
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	4/299	157/9376	0.79892635749739	IGFBP3/ITPR2/ZFP36L1/CCND1	-0.461119118285508
Cellular Processes	Cell motility	hsa04814	Motor proteins	5/299	194/9376	0.80819225597352	ACTB/TNNT3/TNNT2/TNNT1/TUBA1B	-0.489946232818305
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/299	125/9376	0.752588628762542	FCER1G/PLD1/ASAH1	-0.505394355233843
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/299	45/9376	0.696841322928279	CD86	-0.369966354329229
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/299	90/9376	0.696841322928279	FOS/TLR2	-0.524477646301504
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	5/299	205/9376	0.764825842238355	RBPJ/LYN/SYK/TLR2/CCND1	-0.61788584444369
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/299	48/9376	0.653288740245262	HMGCLL1	-0.437063320213513
NA	NA	hsa03272	Virion - Hepatitis viruses	1/299	48/9376	0.653288740245262	CD63	-0.437063320213513
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	4/299	170/9376	0.737831988982884	ACTB/TUBA1B/YBX3/CCND1	-0.626064010990871
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/299	49/9376	0.63995631697495	GXYLT2	-0.458598164202424
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/299	93/9376	0.674362570575754	ACTB/LEF1	-0.57277187096229
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/299	50/9376	0.627157190635452	CD86	-0.479747955884914
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/299	134/9376	0.702041631308341	PRKG1/ITPR2/PLA2G2A	-0.630485451428175
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/299	51/9376	0.61485999081907	ACTB	-0.500529142757144
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	6/299	250/9376	0.752588628762542	DAB2/FOLR2/PLD1/GRK3/PDGFRA/PSD3	-0.719613816329724
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/299	53/9376	0.591657727014577	SLC8A1	-0.541046384476829
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/299	99/9376	0.633492111752981	FOS/CCND1	-0.66534547855063
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/299	99/9376	0.633492111752981	ITPR2/HRH1	-0.66534547855063
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/299	57/9376	0.550137886522326	ELOVL2	-0.618275811109974
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	5/299	224/9376	0.699952221691352	NRP1/EGR1/FOS/SPI1/CCND1	-0.824909838729004
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/299	59/9376	0.531489144606315	ENPP1	-0.65517554805222
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/299	107/9376	0.586128215547151	ITPR2/PYGL	-0.781432252163482
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/299	191/9376	0.656709100141834	GNGT1/GNG10/HDAC9/GNG11	-0.8699403180224
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/299	109/9376	0.575373569390322	CD36/PYGL	-0.809283629045606
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	2/299	110/9376	0.570142900577683	CYBB/RPS6	-0.823046482387362
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/299	63/9376	0.497743802091628	PRDM6	-0.725940193034146
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/299	65/9376	0.482428608181117	PLPP3	-0.759939192100306
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/299	65/9376	0.482428608181117	ITPR2	-0.759939192100306
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/299	66/9376	0.475119083814736	HSD17B2	-0.776618934500111
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	3/299	158/9376	0.595402396172897	WNT2/FZD2/RPS6	-0.930858272405105
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/299	67/9376	0.468027754205561	ITPR2	-0.793094477125209
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/299	70/9376	0.447969421882465	CD36	-0.841357742083267
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/299	70/9376	0.447969421882465	HGF	-0.841357742083267
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/299	119/9376	0.527022849273489	CCL2/FOS	-0.942385454327678
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/299	71/9376	0.441659993405248	LYN	-0.857076914801185
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/299	71/9376	0.441659993405248	PDGFRA	-0.857076914801185
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/299	122/9376	0.514063271012665	CD36/CCND1	-0.980494040543648
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	5/299	253/9376	0.619720544106177	CD14/ITPR2/ACTB/TLR5/UBA52	-1.11286978600837
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/299	75/9376	0.418104793756968	GLUL	-0.918249400672991
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/299	75/9376	0.418104793756968	MGST2	-0.918249400672991
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	3/299	173/9376	0.543777910955594	CCL2/ACTB/TLR7	-1.09922023375526
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/299	77/9376	0.407244928984059	CCND1	-0.947878300974615
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/299	79/9376	0.396934930781931	SYT1	-0.976914079432838
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/299	133/9376	0.471546759876279	KLF2/CCND1	-1.11397635744067
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	3/299	180/9376	0.52263099219621	CCL2/SYK/TLR2	-1.17365662827626
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/299	82/9376	0.382412921119178	MGST2	-1.01942166222073
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/299	83/9376	0.37780553652738	HMGCLL1	-1.0333258275182
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/299	85/9376	0.368915994491442	ENPP1	-1.06075593611354
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/299	138/9376	0.45446173234453	PYGL/RPS6	-1.17172541280302
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/299	86/9376	0.364626273625263	SCN9A	-1.07428790306487
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/299	86/9376	0.364626273625263	RYR2	-1.07428790306487
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/299	144/9376	0.435525826830175	RBPJ/ITPR2	-1.2388749992437
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/299	98/9376	0.319978158487475	ITPR2	-1.228170835707
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/299	98/9376	0.319978158487475	ITPR2	-1.228170835707
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	2/299	158/9376	0.396934930781931	CDKN1C/CCND1	-1.38747264731722
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/299	105/9376	0.298646281254977	UBA52	-1.3116517037334
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/299	163/9376	0.384759012659786	FOS/TLR2	-1.43809836228577
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	2/299	174/9376	0.360435167031869	TUSC3/MAN1A1	-1.54549694165223
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/299	117/9376	0.268015893433954	ACTB	-1.44598106141609
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/299	122/9376	0.257031635506333	FOS	-1.49911708714961
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/299	138/9376	0.227230866172265	ITPR2	-1.65977949856229
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/299	142/9376	0.220829996702624	UBA52	-1.69797591750396
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/299	154/9376	0.20362246449203	ALAS2	-1.80849314494052
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	1/299	156/9376	0.201011920075465	CCND1	-1.82636343382431
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/299	183/9376	0.171354423670888	RPP25	-2.05454565183638
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/299	449/9376	0.209517992417189	SLC8A1/PRKG1/GRK3	-3.11539025449796