ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0005201 extracellular matrix structural constituent 28/492 168/18639 0.166666666666667 6.3140243902439 5.99162422506522e-15 4.49371816879892e-12 GO:0005539 glycosaminoglycan binding 30/492 242/18639 0.12396694214876 4.69638177786737 1.97804915856918e-12 7.41768434463441e-10 GO:0038024 cargo receptor activity 15/492 65/18639 0.230769230769231 8.74249530956848 1.05106767565914e-10 2.62766918914784e-08 GO:0008201 heparin binding 23/492 172/18639 0.133720930232558 5.06590328984685 1.69286278360528e-10 3.1741177192599e-08 GO:0031720 haptoglobin binding 7/492 10/18639 0.7 26.5189024390244 9.59047721740755e-10 1.40772701653761e-07 GO:1901681 sulfur compound binding 28/492 275/18639 0.101818181818182 3.85729490022173 1.12618161323009e-09 1.40772701653761e-07 GO:0005044 scavenger receptor activity 9/492 27/18639 0.333333333333333 12.6280487804878 1.77576764724797e-08 1.90260819347997e-06 GO:0005344 oxygen carrier activity 7/492 14/18639 0.5 18.9420731707317 2.50173228412769e-08 2.3453740163697e-06 GO:0003735 structural constituent of ribosome 19/492 175/18639 0.108571428571429 4.11313588850174 1.99690849241695e-07 1.66409041034746e-05 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 11/492 68/18639 0.161764705882353 6.12831779053085 1.52803678677211e-06 0.000114602759007908 GO:0005518 collagen binding 11/492 72/18639 0.152777777777778 5.78785569105691 2.73928924734474e-06 0.000186769721409868 GO:0038187 pattern recognition receptor activity 9/492 48/18639 0.1875 7.10327743902439 3.88149574991889e-06 0.000242593484369931 GO:0019864 IgG binding 5/492 11/18639 0.454545454545455 17.220066518847 5.08675594779502e-06 0.00027250478291759 GO:0048407 platelet-derived growth factor binding 5/492 11/18639 0.454545454545455 17.220066518847 5.08675594779502e-06 0.00027250478291759 GO:0009055 electron transfer activity 13/492 116/18639 0.112068965517241 4.24563708999159 1.19351615104378e-05 0.000583119298304733 GO:0035325 Toll-like receptor binding 5/492 13/18639 0.384615384615385 14.5708255159475 1.35620865081684e-05 0.000583119298304733 GO:0019838 growth factor binding 14/492 136/18639 0.102941176470588 3.89983859397417 1.48682802789326e-05 0.000583119298304733 GO:0016209 antioxidant activity 11/492 86/18639 0.127906976744186 4.8456466250709 1.59072750865337e-05 0.000583119298304733 GO:0071813 lipoprotein particle binding 7/492 32/18639 0.21875 8.28715701219512 1.62414627489979e-05 0.000583119298304733 GO:0071814 protein-lipid complex binding 7/492 32/18639 0.21875 8.28715701219512 1.62414627489979e-05 0.000583119298304733 GO:0003954 NADH dehydrogenase activity 8/492 44/18639 0.181818181818182 6.8880266075388 1.71048327502722e-05 0.000583119298304733 GO:0030020 extracellular matrix structural constituent conferring tensile strength 8/492 44/18639 0.181818181818182 6.8880266075388 1.71048327502722e-05 0.000583119298304733 GO:0019825 oxygen binding 7/492 34/18639 0.205882352941176 7.79967718794835 2.47996298498239e-05 0.000808683582059475 GO:0030169 low-density lipoprotein particle binding 5/492 17/18639 0.294117647058824 11.1423959827834 5.97403143853243e-05 0.00186688482454138 GO:0050840 extracellular matrix binding 9/492 67/18639 0.134328358208955 5.08891518019658 6.34858082682689e-05 0.00190457424804807 GO:0140375 immune receptor activity 14/492 156/18639 0.0897435897435897 3.39985928705441 6.8859308528634e-05 0.00198632620755675 GO:0008137 NADH dehydrogenase (ubiquinone) activity 7/492 41/18639 0.170731707317073 6.4680249851279 8.8352778207141e-05 0.00241183985714464 GO:0097110 scaffold protein binding 9/492 70/18639 0.128571428571429 4.87081881533101 9.00420213333997e-05 0.00241183985714464 GO:0005178 integrin binding 14/492 161/18639 0.0869565217391304 3.29427359490986 9.68599282814692e-05 0.00250499814521041 GO:0033218 amide binding 18/492 247/18639 0.0728744939271255 2.76078799249531 0.000105384352773103 0.00259295638117115 GO:0016651 oxidoreductase activity, acting on NAD(P)H 10/492 88/18639 0.113636363636364 4.30501662971175 0.000107175530421741 0.00259295638117115 GO:0004601 peroxidase activity 8/492 57/18639 0.140350877192982 5.31707317073171 0.000118120081009792 0.00276843939866701 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 8/492 59/18639 0.135593220338983 5.13683340223233 0.00015137481940141 0.00344033680457749 GO:0004875 complement receptor activity 4/492 12/18639 0.333333333333333 12.6280487804878 0.000200571092062768 0.004424362324914 GO:0030021 extracellular matrix structural constituent conferring compression resistance 5/492 22/18639 0.227272727272727 8.6100332594235 0.000227945721170319 0.00488455116793541 GO:0022853 active monoatomic ion transmembrane transporter activity 11/492 118/18639 0.0932203389830508 3.53157296403473 0.00029211649235442 0.00608576025738376 GO:0001540 amyloid-beta binding 9/492 83/18639 0.108433734939759 4.10791948280929 0.000336389748884662 0.00681871112604045 GO:0043394 proteoglycan binding 6/492 37/18639 0.162162162162162 6.14337508239947 0.000380515489076491 0.00747894152863548 GO:0019763 immunoglobulin receptor activity 4/492 14/18639 0.285714285714286 10.8240418118467 0.000388904959489045 0.00747894152863548 GO:0015399 primary active transmembrane transporter activity 13/492 166/18639 0.0783132530120482 2.96683073758448 0.000474526470233697 0.00889737131688182 GO:0005041 low-density lipoprotein particle receptor activity 4/492 15/18639 0.266666666666667 10.1024390243902 0.000519310990186709 0.00910311984262117 GO:0005523 tropomyosin binding 4/492 15/18639 0.266666666666667 10.1024390243902 0.000519310990186709 0.00910311984262117 GO:0019865 immunoglobulin binding 5/492 26/18639 0.192307692307692 7.28541275797373 0.00052191220431028 0.00910311984262117 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 7/492 58/18639 0.120689655172414 4.57222455845248 0.000803446009631046 0.0136951024368928 GO:0030228 lipoprotein particle receptor activity 4/492 18/18639 0.222222222222222 8.41869918699187 0.00109325747245426 0.0182209578742377 GO:0004713 protein tyrosine kinase activity 11/492 140/18639 0.0785714285714286 2.97661149825784 0.00123424003403526 0.0201234788157923 GO:0015078 proton transmembrane transporter activity 13/492 185/18639 0.0702702702702703 2.6621292023731 0.00130132499587105 0.0207658244021976 GO:0020037 heme binding 11/492 142/18639 0.0774647887323944 2.93468739264857 0.00138463100123127 0.0214708668007709 GO:0120015 sterol transfer activity 5/492 32/18639 0.15625 5.91939786585366 0.00140276329765036 0.0214708668007709 GO:0005021 vascular endothelial growth factor receptor activity 6/492 51/18639 0.117647058823529 4.45695839311334 0.00216008861355475 0.0324013292033213 GO:0046906 tetrapyrrole binding 11/492 152/18639 0.0723684210526316 2.74161585365854 0.00237910363671662 0.0349868181870092 GO:0008046 axon guidance receptor activity 3/492 11/18639 0.272727272727273 10.3320399113082 0.00257508830165072 0.0364399287969442 GO:0050786 RAGE receptor binding 3/492 11/18639 0.272727272727273 10.3320399113082 0.00257508830165072 0.0364399287969442 GO:0061134 peptidase regulator activity 14/492 226/18639 0.0619469026548673 2.34680552557738 0.00281666520813889 0.0391203501130401 GO:0030246 carbohydrate binding 16/492 280/18639 0.0571428571428571 2.16480836236934 0.00327526920875283 0.0440755058159817 GO:0002020 protease binding 10/492 136/18639 0.0735294117647059 2.78559899569584 0.00329408080765083 0.0440755058159817 GO:0005540 hyaluronic acid binding 4/492 24/18639 0.166666666666667 6.3140243902439 0.00334973844201461 0.0440755058159817 GO:0008083 growth factor activity 11/492 162/18639 0.0679012345679012 2.5723803071364 0.00388635719492735 0.0488215577720665 GO:0098631 cell adhesion mediator activity 7/492 76/18639 0.0921052631578947 3.48932926829268 0.00389471576832666 0.0488215577720665 GO:0120020 cholesterol transfer activity 4/492 25/18639 0.16 6.06146341463415 0.00390572462176532 0.0488215577720665 GO:0008035 high-density lipoprotein particle binding 3/492 13/18639 0.230769230769231 8.74249530956848 0.00429146638794128 0.0519128998541284 GO:0070700 BMP receptor binding 3/492 13/18639 0.230769230769231 8.74249530956848 0.00429146638794128 0.0519128998541284 GO:0030247 polysaccharide binding 4/492 26/18639 0.153846153846154 5.82833020637899 0.00452096324312077 0.053820990989533 GO:0042056 chemoattractant activity 5/492 42/18639 0.119047619047619 4.51001742160279 0.00477581661472314 0.0559666009537868 GO:0004714 transmembrane receptor protein tyrosine kinase activity 6/492 60/18639 0.1 3.78841463414634 0.00492311023379609 0.0568051180822625 GO:0048156 tau protein binding 5/492 43/18639 0.116279069767442 4.405133295519 0.00528932786979564 0.059952999884034 GO:0005161 platelet-derived growth factor receptor binding 3/492 14/18639 0.214285714285714 8.11803135888502 0.0053558013229737 0.059952999884034 GO:0001664 G protein-coupled receptor binding 16/492 297/18639 0.0538720538720539 2.04089677260409 0.00575410325919432 0.0634643741822903 GO:0004715 non-membrane spanning protein tyrosine kinase activity 5/492 45/18639 0.111111111111111 4.20934959349593 0.00643128272343919 0.0699052469939043 GO:0004129 cytochrome-c oxidase activity 3/492 15/18639 0.2 7.57682926829268 0.00656492390617046 0.0703384704232549 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/492 16/18639 0.1875 7.10327743902439 0.0079234338961507 0.0836982453818736 GO:0017147 Wnt-protein binding 4/492 31/18639 0.129032258064516 4.8882769472856 0.00857911794022423 0.0881416226735366 GO:0070325 lipoprotein particle receptor binding 4/492 31/18639 0.129032258064516 4.8882769472856 0.00857911794022423 0.0881416226735366 GO:0015278 intracellularly gated calcium channel activity 3/492 17/18639 0.176470588235294 6.68543758967001 0.00943524924941136 0.0947793894137362 GO:0005125 cytokine activity 13/492 234/18639 0.0555555555555556 2.10467479674797 0.00953443446747702 0.0947793894137362 GO:0043425 bHLH transcription factor binding 4/492 32/18639 0.125 4.73551829268293 0.00960431146059194 0.0947793894137362 GO:0043178 alcohol binding 7/492 92/18639 0.0760869565217391 2.88248939554613 0.0109152184850027 0.105563560610205 GO:0098641 cadherin binding involved in cell-cell adhesion 3/492 18/18639 0.166666666666667 6.3140243902439 0.0111036476048028 0.105563560610205 GO:0035401 histone H3Y41 kinase activity 8/492 115/18639 0.0695652173913043 2.63541887592789 0.0112601131317553 0.105563560610205 GO:0140801 histone H2AXY142 kinase activity 8/492 115/18639 0.0695652173913043 2.63541887592789 0.0112601131317553 0.105563560610205 GO:0001216 DNA-binding transcription activator activity 22/492 491/18639 0.044806517311609 1.69745665888431 0.0114857283820259 0.10634933687061 GO:0098632 cell-cell adhesion mediator activity 5/492 55/18639 0.0909090909090909 3.4440133037694 0.0147889963845264 0.133217301109134 GO:0005126 cytokine receptor binding 14/492 275/18639 0.0509090909090909 1.92864745011086 0.014891543856072 0.133217301109134 GO:0016004 phospholipase activator activity 3/492 20/18639 0.15 5.68262195121951 0.014920337724223 0.133217301109134 GO:0019199 transmembrane receptor protein kinase activity 6/492 78/18639 0.0769230769230769 2.91416510318949 0.0170311442211225 0.147175257817052 GO:0016504 peptidase activator activity 5/492 57/18639 0.087719298245614 3.32317073170732 0.0170590255476071 0.147175257817052 GO:0001846 opsonin binding 3/492 21/18639 0.142857142857143 5.41202090592335 0.017072329906778 0.147175257817052 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 21/492 484/18639 0.0433884297520661 1.64373362225358 0.0184182463749465 0.156973690695567 GO:0008093 cytoskeletal anchor activity 3/492 22/18639 0.136363636363636 5.1660199556541 0.0193883760416116 0.161116428283085 GO:0042826 histone deacetylase binding 8/492 127/18639 0.062992125984252 2.3864029191473 0.0194787323609758 0.161116428283085 GO:0070888 E-box binding 5/492 59/18639 0.0847457627118644 3.2105208763952 0.0195487932983476 0.161116428283085 GO:0005506 iron ion binding 9/492 154/18639 0.0584415584415584 2.21400855242319 0.0212241997590036 0.173023367600573 GO:0031681 G-protein beta-subunit binding 3/492 23/18639 0.130434782608696 4.94141039236479 0.0218691093909961 0.176363785411259 GO:0001530 lipopolysaccharide binding 4/492 41/18639 0.0975609756097561 3.69601427721594 0.0224812818177954 0.179371929397304 GO:0005543 phospholipid binding 21/492 497/18639 0.0422535211267606 1.60073857780831 0.0238215737700986 0.187612758767443 GO:0008307 structural constituent of muscle 4/492 42/18639 0.0952380952380952 3.60801393728223 0.0243450149970662 0.187612758767443 GO:0060229 lipase activator activity 3/492 24/18639 0.125 4.73551829268293 0.0245147338122792 0.187612758767443 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 3/492 24/18639 0.125 4.73551829268293 0.0245147338122792 0.187612758767443 GO:0003779 actin binding 19/492 443/18639 0.0428893905191874 1.62482794692507 0.026785601555232 0.196720499032057 GO:0005381 iron ion transmembrane transporter activity 2/492 10/18639 0.2 7.57682926829268 0.0271942941904473 0.196720499032057 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/492 10/18639 0.2 7.57682926829268 0.0271942941904473 0.196720499032057 GO:0043208 glycosphingolipid binding 2/492 10/18639 0.2 7.57682926829268 0.0271942941904473 0.196720499032057 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/492 10/18639 0.2 7.57682926829268 0.0271942941904473 0.196720499032057 GO:0001848 complement binding 3/492 25/18639 0.12 4.54609756097561 0.0273250532473493 0.196720499032057 GO:0008081 phosphoric diester hydrolase activity 6/492 87/18639 0.0689655172413793 2.61269974768713 0.0275408698644879 0.196720499032057 GO:0004857 enzyme inhibitor activity 18/492 416/18639 0.0432692307692308 1.63921787054409 0.0283495016677889 0.199109181169711 GO:0120013 lipid transfer activity 5/492 65/18639 0.0769230769230769 2.91416510318949 0.0284062431802121 0.199109181169711 GO:0004197 cysteine-type endopeptidase activity 6/492 88/18639 0.0681818181818182 2.58300997782705 0.0289233418561232 0.200856540667522 GO:0008198 ferrous iron binding 3/492 26/18639 0.115384615384615 4.37124765478424 0.0302994997696399 0.205968080249905 GO:0050750 low-density lipoprotein particle receptor binding 3/492 26/18639 0.115384615384615 4.37124765478424 0.0302994997696399 0.205968080249905 GO:0008009 chemokine activity 4/492 45/18639 0.0888888888888889 3.36747967479675 0.0304832758769859 0.205968080249905 GO:0070851 growth factor receptor binding 8/492 139/18639 0.0575539568345324 2.18038252324969 0.0312763773041963 0.207617979866962 GO:0016500 protein-hormone receptor activity 5/492 67/18639 0.0746268656716418 2.82717510010921 0.0318409422158086 0.207617979866962 GO:0001851 complement component C3b binding 2/492 11/18639 0.181818181818182 6.8880266075388 0.0326652288324021 0.207617979866962 GO:0008199 ferric iron binding 2/492 11/18639 0.181818181818182 6.8880266075388 0.0326652288324021 0.207617979866962 GO:0050998 nitric-oxide synthase binding 2/492 11/18639 0.181818181818182 6.8880266075388 0.0326652288324021 0.207617979866962 GO:0140031 phosphorylation-dependent protein binding 2/492 11/18639 0.181818181818182 6.8880266075388 0.0326652288324021 0.207617979866962 GO:1990948 ubiquitin ligase inhibitor activity 2/492 11/18639 0.181818181818182 6.8880266075388 0.0326652288324021 0.207617979866962 GO:0030414 peptidase inhibitor activity 9/492 169/18639 0.0532544378698225 2.01749891759273 0.0356654583008774 0.216889722916468 GO:0045499 chemorepellent activity 3/492 28/18639 0.107142857142857 4.05901567944251 0.0367368016918197 0.216889722916468 GO:0046625 sphingolipid binding 3/492 28/18639 0.107142857142857 4.05901567944251 0.0367368016918197 0.216889722916468 GO:0046875 ephrin receptor binding 3/492 28/18639 0.107142857142857 4.05901567944251 0.0367368016918197 0.216889722916468 GO:0019955 cytokine binding 8/492 144/18639 0.0555555555555556 2.10467479674797 0.0373893618161611 0.216889722916468 GO:0016208 AMP binding 2/492 12/18639 0.166666666666667 6.3140243902439 0.0385249557912465 0.216889722916468 GO:0045295 gamma-catenin binding 2/492 12/18639 0.166666666666667 6.3140243902439 0.0385249557912465 0.216889722916468 GO:0097677 STAT family protein binding 2/492 12/18639 0.166666666666667 6.3140243902439 0.0385249557912465 0.216889722916468 GO:0005004 GPI-linked ephrin receptor activity 4/492 49/18639 0.0816326530612245 3.09258337481334 0.0399644451791198 0.216889722916468 GO:0005008 hepatocyte growth factor receptor activity 4/492 49/18639 0.0816326530612245 3.09258337481334 0.0399644451791198 0.216889722916468 GO:0005009 insulin receptor activity 4/492 49/18639 0.0816326530612245 3.09258337481334 0.0399644451791198 0.216889722916468 GO:0005011 macrophage colony-stimulating factor receptor activity 4/492 49/18639 0.0816326530612245 3.09258337481334 0.0399644451791198 0.216889722916468 GO:0005018 platelet-derived growth factor alpha-receptor activity 4/492 49/18639 0.0816326530612245 3.09258337481334 0.0399644451791198 0.216889722916468 GO:0005020 stem cell factor receptor activity 4/492 49/18639 0.0816326530612245 3.09258337481334 0.0399644451791198 0.216889722916468 GO:0008288 boss receptor activity 4/492 49/18639 0.0816326530612245 3.09258337481334 0.0399644451791198 0.216889722916468 GO:0036332 placental growth factor receptor activity 4/492 49/18639 0.0816326530612245 3.09258337481334 0.0399644451791198 0.216889722916468 GO:0038062 protein tyrosine kinase collagen receptor activity 4/492 49/18639 0.0816326530612245 3.09258337481334 0.0399644451791198 0.216889722916468 GO:0060175 brain-derived neurotrophic factor receptor activity 4/492 49/18639 0.0816326530612245 3.09258337481334 0.0399644451791198 0.216889722916468 GO:0003785 actin monomer binding 3/492 29/18639 0.103448275862069 3.9190496215307 0.040196895313852 0.216889722916468 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/492 29/18639 0.103448275862069 3.9190496215307 0.040196895313852 0.216889722916468 GO:0099604 ligand-gated calcium channel activity 3/492 29/18639 0.103448275862069 3.9190496215307 0.040196895313852 0.216889722916468 GO:0004896 cytokine receptor activity 6/492 96/18639 0.0625 2.36775914634146 0.041634226007763 0.220548520452306 GO:0005006 epidermal growth factor receptor activity 4/492 50/18639 0.08 3.03073170731707 0.0425682321699043 0.220548520452306 GO:0005007 fibroblast growth factor receptor activity 4/492 50/18639 0.08 3.03073170731707 0.0425682321699043 0.220548520452306 GO:0005017 platelet-derived growth factor receptor activity 4/492 50/18639 0.08 3.03073170731707 0.0425682321699043 0.220548520452306 GO:0005019 platelet-derived growth factor beta-receptor activity 4/492 50/18639 0.08 3.03073170731707 0.0425682321699043 0.220548520452306 GO:0043539 protein serine/threonine kinase activator activity 5/492 73/18639 0.0684931506849315 2.59480454393585 0.0436519190014816 0.220548520452306 GO:0001968 fibronectin binding 3/492 30/18639 0.1 3.78841463414634 0.0438156393965247 0.220548520452306 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 3/492 30/18639 0.1 3.78841463414634 0.0438156393965247 0.220548520452306 GO:0031210 phosphatidylcholine binding 3/492 30/18639 0.1 3.78841463414634 0.0438156393965247 0.220548520452306 GO:0033612 receptor serine/threonine kinase binding 3/492 30/18639 0.1 3.78841463414634 0.0438156393965247 0.220548520452306 GO:0017154 semaphorin receptor activity 2/492 13/18639 0.153846153846154 5.82833020637899 0.0447492265918474 0.223349508648272 GO:0005010 insulin-like growth factor receptor activity 4/492 51/18639 0.0784313725490196 2.9713055954089 0.0452655004193832 0.223349508648272 GO:0005030 neurotrophin receptor activity 4/492 51/18639 0.0784313725490196 2.9713055954089 0.0452655004193832 0.223349508648272 GO:0005319 lipid transporter activity 9/492 178/18639 0.050561797752809 1.91549054535489 0.0469886331334269 0.230336436928563 GO:0005003 ephrin receptor activity 4/492 53/18639 0.0754716981132075 2.8591808559595 0.0509398190916435 0.239044087593135 GO:0005005 transmembrane-ephrin receptor activity 4/492 53/18639 0.0754716981132075 2.8591808559595 0.0509398190916435 0.239044087593135 GO:0016860 intramolecular oxidoreductase activity 4/492 53/18639 0.0754716981132075 2.8591808559595 0.0509398190916435 0.239044087593135 GO:0017046 peptide hormone binding 4/492 53/18639 0.0754716981132075 2.8591808559595 0.0509398190916435 0.239044087593135 GO:0038064 collagen receptor activity 4/492 53/18639 0.0754716981132075 2.8591808559595 0.0509398190916435 0.239044087593135 GO:0005545 1-phosphatidylinositol binding 2/492 14/18639 0.142857142857143 5.41202090592335 0.0513147974699931 0.239044087593135 GO:0008191 metalloendopeptidase inhibitor activity 2/492 14/18639 0.142857142857143 5.41202090592335 0.0513147974699931 0.239044087593135 GO:0044548 S100 protein binding 2/492 14/18639 0.142857142857143 5.41202090592335 0.0513147974699931 0.239044087593135 GO:0015485 cholesterol binding 4/492 54/18639 0.0740740740740741 2.80623306233062 0.0539162928019043 0.249612466675483 GO:0030296 protein tyrosine kinase activator activity 3/492 33/18639 0.0909090909090909 3.4440133037694 0.0556021110343336 0.254885442795733 GO:0061135 endopeptidase regulator activity 9/492 184/18639 0.0489130434782609 1.8530288971368 0.0557349501580004 0.254885442795733 GO:0005096 GTPase activator activity 12/492 271/18639 0.044280442804428 1.67752677526775 0.0567045868975703 0.257748122261683 GO:0033293 monocarboxylic acid binding 5/492 79/18639 0.0632911392405063 2.39773078110528 0.0577725606186875 0.259457607568956 GO:0046332 SMAD binding 5/492 79/18639 0.0632911392405063 2.39773078110528 0.0577725606186875 0.259457607568956 GO:0055105 ubiquitin-protein transferase inhibitor activity 2/492 15/18639 0.133333333333333 5.05121951219512 0.0581993934028888 0.259818720548611 GO:0048306 calcium-dependent protein binding 5/492 80/18639 0.0625 2.36775914634146 0.0603522763156329 0.266766091173485 GO:0022804 active transmembrane transporter activity 18/492 457/18639 0.0393873085339169 1.49215456049528 0.0604669806659898 0.266766091173485 GO:0030695 GTPase regulator activity 19/492 489/18639 0.0388548057259714 1.47198114619183 0.0610977034399928 0.26797238350874 GO:0008013 beta-catenin binding 6/492 106/18639 0.0566037735849057 2.14438564196963 0.0618292047371547 0.269133472980266 GO:0060589 nucleoside-triphosphatase regulator activity 19/492 490/18639 0.0387755102040816 1.46897710303634 0.0620801211007813 0.269133472980266 GO:0001618 virus receptor activity 5/492 81/18639 0.0617283950617284 2.33852755194219 0.0629965103275151 0.271536682446186 GO:0043177 organic acid binding 9/492 189/18639 0.0476190476190476 1.80400696864111 0.0637812962726909 0.272623905914382 GO:0004866 endopeptidase inhibitor activity 8/492 161/18639 0.0496894409937888 1.88244205423421 0.0639757432545749 0.272623905914382 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/492 16/18639 0.125 4.73551829268293 0.0653816733324229 0.275300750015484 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/492 16/18639 0.125 4.73551829268293 0.0653816733324229 0.275300750015484 GO:0140272 exogenous protein binding 5/492 82/18639 0.0609756097560976 2.31000892325996 0.0657051123370288 0.275300750015484 GO:0044325 transmembrane transporter binding 7/492 136/18639 0.0514705882352941 1.94991929698709 0.0690764143524501 0.287818393135209 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/492 17/18639 0.117647058823529 4.45695839311334 0.0728411965434911 0.295927112049162 GO:0019198 transmembrane receptor protein phosphatase activity 2/492 17/18639 0.117647058823529 4.45695839311334 0.0728411965434911 0.295927112049162 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/492 17/18639 0.117647058823529 4.45695839311334 0.0728411965434911 0.295927112049162 GO:0048038 quinone binding 2/492 17/18639 0.117647058823529 4.45695839311334 0.0728411965434911 0.295927112049162 GO:0031267 small GTPase binding 12/492 283/18639 0.0424028268551237 1.60639489787124 0.0732430575882983 0.295927112049162 GO:0042805 actinin binding 3/492 37/18639 0.0810810810810811 3.07168754119974 0.0733899237881922 0.295927112049162 GO:0030295 protein kinase activator activity 7/492 139/18639 0.0503597122302158 1.90783470784348 0.0756634783722859 0.303463148551949 GO:0005200 structural constituent of cytoskeleton 6/492 112/18639 0.0535714285714286 2.02950783972125 0.0763013461722755 0.304393668240461 GO:0015026 coreceptor activity 4/492 61/18639 0.0655737704918033 2.48420631747301 0.0773018680654574 0.306753444704196 GO:0005109 frizzled binding 3/492 38/18639 0.0789473684210526 2.99085365853659 0.0781869234360041 0.308259146023573 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 14/492 349/18639 0.0401146131805158 1.51970787616186 0.0803019330720165 0.308259146023573 GO:0008525 phosphatidylcholine transporter activity 2/492 18/18639 0.111111111111111 4.20934959349593 0.0805583901608271 0.308259146023573 GO:0017075 syntaxin-1 binding 2/492 18/18639 0.111111111111111 4.20934959349593 0.0805583901608271 0.308259146023573 GO:0034185 apolipoprotein binding 2/492 18/18639 0.111111111111111 4.20934959349593 0.0805583901608271 0.308259146023573 GO:0035615 clathrin adaptor activity 2/492 18/18639 0.111111111111111 4.20934959349593 0.0805583901608271 0.308259146023573 GO:0070064 proline-rich region binding 2/492 18/18639 0.111111111111111 4.20934959349593 0.0805583901608271 0.308259146023573 GO:0005507 copper ion binding 4/492 63/18639 0.0634920634920635 2.40534262485482 0.0847795718968249 0.322764867627506 GO:0050997 quaternary ammonium group binding 3/492 40/18639 0.075 2.84131097560976 0.0881775742706336 0.32864301136968 GO:0042834 peptidoglycan binding 2/492 19/18639 0.105263157894737 3.98780487804878 0.0885145177289004 0.32864301136968 GO:0043395 heparan sulfate proteoglycan binding 2/492 19/18639 0.105263157894737 3.98780487804878 0.0885145177289004 0.32864301136968 GO:0046624 sphingolipid transporter activity 2/492 19/18639 0.105263157894737 3.98780487804878 0.0885145177289004 0.32864301136968 GO:0097001 ceramide binding 2/492 19/18639 0.105263157894737 3.98780487804878 0.0885145177289004 0.32864301136968 GO:0019208 phosphatase regulator activity 6/492 117/18639 0.0512820512820513 1.94277673545966 0.0897043839047024 0.33142013757895 GO:0072341 modified amino acid binding 5/492 91/18639 0.0549450549450549 2.08154650227821 0.0929334592777543 0.341667129697626 GO:0019209 kinase activator activity 7/492 148/18639 0.0472972972972973 1.79181773236651 0.0975542136651336 0.356905659750489 GO:0019894 kinesin binding 3/492 42/18639 0.0714285714285714 2.70601045296167 0.0986732858807848 0.359247400051401 GO:0051219 phosphoprotein binding 5/492 93/18639 0.0537634408602151 2.036782061369 0.0996632634371459 0.361098780569369 GO:0042562 hormone binding 5/492 94/18639 0.0531914893617021 2.01511416709912 0.103117611902644 0.369974048524388 GO:0032934 sterol binding 4/492 68/18639 0.0588235294117647 2.22847919655667 0.104935490936994 0.369974048524388 GO:1990841 promoter-specific chromatin binding 4/492 68/18639 0.0588235294117647 2.22847919655667 0.104935490936994 0.369974048524388 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/492 21/18639 0.0952380952380952 3.60801393728223 0.105072629780926 0.369974048524388 GO:0072542 protein phosphatase activator activity 2/492 21/18639 0.0952380952380952 3.60801393728223 0.105072629780926 0.369974048524388 GO:0140312 cargo adaptor activity 2/492 21/18639 0.0952380952380952 3.60801393728223 0.105072629780926 0.369974048524388 GO:0140517 protein-RNA adaptor activity 2/492 22/18639 0.0909090909090909 3.4440133037694 0.113641055154858 0.398274726010015 GO:0046915 transition metal ion transmembrane transporter activity 3/492 45/18639 0.0666666666666667 2.52560975609756 0.115298815469569 0.402205170242681 GO:0001217 DNA-binding transcription repressor activity 11/492 278/18639 0.039568345323741 1.49901298473416 0.11971839649561 0.415688876720867 GO:0005158 insulin receptor binding 2/492 23/18639 0.0869565217391304 3.29427359490986 0.122381240465702 0.420861205133824 GO:0042379 chemokine receptor binding 4/492 72/18639 0.0555555555555556 2.10467479674797 0.122476054898929 0.420861205133824 GO:0031406 carboxylic acid binding 8/492 187/18639 0.0427807486631016 1.62071214295031 0.122891471899077 0.420861205133824 GO:0042277 peptide binding 10/492 249/18639 0.0401606425702811 1.52145166029974 0.12461176287152 0.42481282797109 GO:0005504 fatty acid binding 3/492 47/18639 0.0638297872340425 2.41813700051894 0.126925777097988 0.43074358743661 GO:0051020 GTPase binding 12/492 315/18639 0.0380952380952381 1.44320557491289 0.131213409631153 0.437009953947398 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/492 24/18639 0.0833333333333333 3.15701219512195 0.131278195616013 0.437009953947398 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/492 24/18639 0.0833333333333333 3.15701219512195 0.131278195616013 0.437009953947398 GO:0048027 mRNA 5'-UTR binding 2/492 24/18639 0.0833333333333333 3.15701219512195 0.131278195616013 0.437009953947398 GO:0048029 monosaccharide binding 4/492 74/18639 0.0540540540540541 2.04779169413316 0.131685666122816 0.437009953947398 GO:0019887 protein kinase regulator activity 10/492 255/18639 0.0392156862745098 1.48565279770445 0.13899079799654 0.457557389022536 GO:0019207 kinase regulator activity 11/492 287/18639 0.0383275261324042 1.45200560890626 0.139803195648575 0.457557389022536 GO:0005537 D-mannose binding 2/492 25/18639 0.08 3.03073170731707 0.140317599300244 0.457557389022536 GO:0019211 phosphatase activator activity 2/492 25/18639 0.08 3.03073170731707 0.140317599300244 0.457557389022536 GO:0048020 CCR chemokine receptor binding 3/492 50/18639 0.06 2.2730487804878 0.145103036852038 0.471113756013112 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/492 26/18639 0.0769230769230769 2.91416510318949 0.149485774261128 0.483251425413129 GO:0140297 DNA-binding transcription factor binding 17/492 488/18639 0.0348360655737705 1.31973460615754 0.150244210893567 0.483618704593027 GO:0005080 protein kinase C binding 3/492 52/18639 0.0576923076923077 2.18562382739212 0.157666562887044 0.502435643614255 GO:0004364 glutathione transferase activity 2/492 27/18639 0.0740740740740741 2.80623306233062 0.158769663382105 0.502435643614255 GO:0005104 fibroblast growth factor receptor binding 2/492 27/18639 0.0740740740740741 2.80623306233062 0.158769663382105 0.502435643614255 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/492 27/18639 0.0740740740740741 2.80623306233062 0.158769663382105 0.502435643614255 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3/492 54/18639 0.0555555555555556 2.10467479674797 0.17054980720376 0.53744687144042 GO:0140313 molecular sequestering activity 3/492 55/18639 0.0545454545454545 2.06640798226164 0.177101617213743 0.555110370423002 GO:0051861 glycolipid binding 2/492 29/18639 0.0689655172413793 2.61269974768713 0.177635318535361 0.555110370423002 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/492 30/18639 0.0666666666666667 2.52560975609756 0.187193867045277 0.580146282165116 GO:0070566 adenylyltransferase activity 2/492 30/18639 0.0666666666666667 2.52560975609756 0.187193867045277 0.580146282165116 GO:0051015 actin filament binding 8/492 209/18639 0.0382775119617225 1.45011086474501 0.189051318399495 0.58349172345523 GO:0001786 phosphatidylserine binding 3/492 59/18639 0.0508474576271186 1.92631252583712 0.203954385194372 0.626908970884339 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2/492 33/18639 0.0606060606060606 2.2960088691796 0.216244275431938 0.655240097873594 GO:0140311 protein sequestering activity 2/492 33/18639 0.0606060606060606 2.2960088691796 0.216244275431938 0.655240097873594 GO:0140416 transcription regulator inhibitor activity 2/492 33/18639 0.0606060606060606 2.2960088691796 0.216244275431938 0.655240097873594 GO:0019905 syntaxin binding 3/492 61/18639 0.0491803278688525 1.86315473810476 0.217715857007925 0.655240097873594 GO:0035091 phosphatidylinositol binding 10/492 284/18639 0.0352112676056338 1.33394881484026 0.21951842012736 0.655240097873594 GO:0000182 rDNA binding 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0003796 lysozyme activity 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0005131 growth hormone receptor binding 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0008239 dipeptidyl-peptidase activity 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0030957 Tat protein binding 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0032052 bile acid binding 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0033204 ribonuclease P RNA binding 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0043295 glutathione binding 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0047429 nucleoside triphosphate diphosphatase activity 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0070097 delta-catenin binding 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0071723 lipopeptide binding 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/492 10/18639 0.1 3.78841463414634 0.234766680025429 0.655240097873594 GO:0043015 gamma-tubulin binding 2/492 35/18639 0.0571428571428571 2.16480836236934 0.235826689029688 0.655240097873594 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/492 36/18639 0.0555555555555556 2.10467479674797 0.245655922723712 0.655240097873594 GO:0055106 ubiquitin-protein transferase regulator activity 2/492 36/18639 0.0555555555555556 2.10467479674797 0.245655922723712 0.655240097873594 GO:0019843 rRNA binding 3/492 65/18639 0.0461538461538462 1.7484990619137 0.245764915058578 0.655240097873594 GO:0099106 ion channel regulator activity 6/492 160/18639 0.0375 1.42065548780488 0.248386467059803 0.655240097873594 GO:0003953 NAD+ nucleosidase activity 1/492 11/18639 0.0909090909090909 3.4440133037694 0.254976825144731 0.655240097873594 GO:0005536 D-glucose binding 1/492 11/18639 0.0909090909090909 3.4440133037694 0.254976825144731 0.655240097873594 GO:0008172 S-methyltransferase activity 1/492 11/18639 0.0909090909090909 3.4440133037694 0.254976825144731 0.655240097873594 GO:0008526 phosphatidylinositol transfer activity 1/492 11/18639 0.0909090909090909 3.4440133037694 0.254976825144731 0.655240097873594 GO:0015173 aromatic amino acid transmembrane transporter activity 1/492 11/18639 0.0909090909090909 3.4440133037694 0.254976825144731 0.655240097873594 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/492 11/18639 0.0909090909090909 3.4440133037694 0.254976825144731 0.655240097873594 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/492 11/18639 0.0909090909090909 3.4440133037694 0.254976825144731 0.655240097873594 GO:0032050 clathrin heavy chain binding 1/492 11/18639 0.0909090909090909 3.4440133037694 0.254976825144731 0.655240097873594 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/492 11/18639 0.0909090909090909 3.4440133037694 0.254976825144731 0.655240097873594 GO:0035252 UDP-xylosyltransferase activity 1/492 11/18639 0.0909090909090909 3.4440133037694 0.254976825144731 0.655240097873594 GO:0042285 xylosyltransferase activity 1/492 11/18639 0.0909090909090909 3.4440133037694 0.254976825144731 0.655240097873594 GO:0045294 alpha-catenin binding 1/492 11/18639 0.0909090909090909 3.4440133037694 0.254976825144731 0.655240097873594 GO:0097493 structural molecule activity conferring elasticity 1/492 11/18639 0.0909090909090909 3.4440133037694 0.254976825144731 0.655240097873594 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/492 11/18639 0.0909090909090909 3.4440133037694 0.254976825144731 0.655240097873594 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/492 11/18639 0.0909090909090909 3.4440133037694 0.254976825144731 0.655240097873594 GO:1900750 oligopeptide binding 1/492 11/18639 0.0909090909090909 3.4440133037694 0.254976825144731 0.655240097873594 GO:0022829 wide pore channel activity 2/492 37/18639 0.0540540540540541 2.04779169413316 0.255499694091456 0.655240097873594 GO:0016798 hydrolase activity, acting on glycosyl bonds 5/492 130/18639 0.0384615384615385 1.45708255159475 0.259853463398833 0.655240097873594 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 3/492 67/18639 0.0447761194029851 1.69630506006553 0.259997462842781 0.655240097873594 GO:0005085 guanyl-nucleotide exchange factor activity 8/492 230/18639 0.0347826086956522 1.31770943796394 0.263283388191699 0.655240097873594 GO:0005501 retinoid binding 2/492 38/18639 0.0526315789473684 1.99390243902439 0.265350403572314 0.655240097873594 GO:0019840 isoprenoid binding 2/492 38/18639 0.0526315789473684 1.99390243902439 0.265350403572314 0.655240097873594 GO:0045296 cadherin binding 11/492 334/18639 0.0329341317365269 1.24768146633562 0.269327392738297 0.655240097873594 GO:0005179 hormone activity 5/492 132/18639 0.0378787878787879 1.43500554323725 0.269906460419009 0.655240097873594 GO:0000340 RNA 7-methylguanosine cap binding 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:0004526 ribonuclease P activity 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:0005095 GTPase inhibitor activity 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:0005165 neurotrophin receptor binding 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:0005247 voltage-gated chloride channel activity 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:0015132 prostaglandin transmembrane transporter activity 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:0015368 calcium:monoatomic cation antiporter activity 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:0035197 siRNA binding 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:0035497 cAMP response element binding 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:0070008 serine-type exopeptidase activity 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:0070679 inositol 1,4,5 trisphosphate binding 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:0097371 MDM2/MDM4 family protein binding 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/492 12/18639 0.0833333333333333 3.15701219512195 0.274654267813229 0.655240097873594 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/492 39/18639 0.0512820512820513 1.94277673545966 0.275200841106909 0.655240097873594 GO:0016247 channel regulator activity 6/492 168/18639 0.0357142857142857 1.35300522648084 0.284172428796727 0.666130836492512 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 2/492 40/18639 0.05 1.89420731707317 0.285044170940398 0.666130836492512 GO:0071855 neuropeptide receptor binding 2/492 40/18639 0.05 1.89420731707317 0.285044170940398 0.666130836492512 GO:0141108 transporter regulator activity 6/492 170/18639 0.0352941176470588 1.337087517934 0.293295918166226 0.666130836492512 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/492 13/18639 0.0769230769230769 2.91416510318949 0.293813021248345 0.666130836492512 GO:0005542 folic acid binding 1/492 13/18639 0.0769230769230769 2.91416510318949 0.293813021248345 0.666130836492512 GO:0031994 insulin-like growth factor I binding 1/492 13/18639 0.0769230769230769 2.91416510318949 0.293813021248345 0.666130836492512 GO:0032396 inhibitory MHC class I receptor activity 1/492 13/18639 0.0769230769230769 2.91416510318949 0.293813021248345 0.666130836492512 GO:0035673 oligopeptide transmembrane transporter activity 1/492 13/18639 0.0769230769230769 2.91416510318949 0.293813021248345 0.666130836492512 GO:0039706 co-receptor binding 1/492 13/18639 0.0769230769230769 2.91416510318949 0.293813021248345 0.666130836492512 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/492 13/18639 0.0769230769230769 2.91416510318949 0.293813021248345 0.666130836492512 GO:0071714 icosanoid transmembrane transporter activity 1/492 13/18639 0.0769230769230769 2.91416510318949 0.293813021248345 0.666130836492512 GO:0071837 HMG box domain binding 1/492 13/18639 0.0769230769230769 2.91416510318949 0.293813021248345 0.666130836492512 GO:0089720 caspase binding 1/492 13/18639 0.0769230769230769 2.91416510318949 0.293813021248345 0.666130836492512 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 2/492 41/18639 0.0487804878048781 1.84800713860797 0.294873916954018 0.666130836492512 GO:0017080 sodium channel regulator activity 2/492 41/18639 0.0487804878048781 1.84800713860797 0.294873916954018 0.666130836492512 GO:0140828 metal cation:monoatomic cation antiporter activity 2/492 41/18639 0.0487804878048781 1.84800713860797 0.294873916954018 0.666130836492512 GO:0048487 beta-tubulin binding 2/492 42/18639 0.0476190476190476 1.80400696864111 0.304683948507679 0.672255114575736 GO:0000149 SNARE binding 4/492 106/18639 0.0377358490566038 1.42959042797975 0.306851751601214 0.672255114575736 GO:0008195 phosphatidate phosphatase activity 1/492 14/18639 0.0714285714285714 2.70601045296167 0.312466730769756 0.672255114575736 GO:0008559 ABC-type xenobiotic transporter activity 1/492 14/18639 0.0714285714285714 2.70601045296167 0.312466730769756 0.672255114575736 GO:0015386 potassium:proton antiporter activity 1/492 14/18639 0.0714285714285714 2.70601045296167 0.312466730769756 0.672255114575736 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/492 14/18639 0.0714285714285714 2.70601045296167 0.312466730769756 0.672255114575736 GO:0019992 diacylglycerol binding 1/492 14/18639 0.0714285714285714 2.70601045296167 0.312466730769756 0.672255114575736 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/492 14/18639 0.0714285714285714 2.70601045296167 0.312466730769756 0.672255114575736 GO:0031404 chloride ion binding 1/492 14/18639 0.0714285714285714 2.70601045296167 0.312466730769756 0.672255114575736 GO:0034236 protein kinase A catalytic subunit binding 1/492 14/18639 0.0714285714285714 2.70601045296167 0.312466730769756 0.672255114575736 GO:0042043 neurexin family protein binding 1/492 14/18639 0.0714285714285714 2.70601045296167 0.312466730769756 0.672255114575736 GO:0042813 Wnt receptor activity 1/492 14/18639 0.0714285714285714 2.70601045296167 0.312466730769756 0.672255114575736 GO:0061783 peptidoglycan muralytic activity 1/492 14/18639 0.0714285714285714 2.70601045296167 0.312466730769756 0.672255114575736 GO:0070742 C2H2 zinc finger domain binding 1/492 14/18639 0.0714285714285714 2.70601045296167 0.312466730769756 0.672255114575736 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/492 14/18639 0.0714285714285714 2.70601045296167 0.312466730769756 0.672255114575736 GO:1901474 azole transmembrane transporter activity 1/492 14/18639 0.0714285714285714 2.70601045296167 0.312466730769756 0.672255114575736 GO:0019888 protein phosphatase regulator activity 4/492 107/18639 0.0373831775700935 1.41622976977433 0.312822713315909 0.672255114575736 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/492 43/18639 0.0465116279069767 1.7620533182076 0.314468466776914 0.673321388876381 GO:0004518 nuclease activity 7/492 209/18639 0.0334928229665072 1.26884700665188 0.315114409994146 0.673321388876381 GO:0005496 steroid binding 4/492 108/18639 0.037037037037037 1.40311653116531 0.318804146445224 0.679270198391812 GO:0043014 alpha-tubulin binding 2/492 44/18639 0.0454545454545455 1.7220066518847 0.324221991568033 0.680296518449046 GO:0004089 carbonate dehydratase activity 1/492 15/18639 0.0666666666666667 2.52560975609756 0.330628683438819 0.680296518449046 GO:0004559 alpha-mannosidase activity 1/492 15/18639 0.0666666666666667 2.52560975609756 0.330628683438819 0.680296518449046 GO:0016846 carbon-sulfur lyase activity 1/492 15/18639 0.0666666666666667 2.52560975609756 0.330628683438819 0.680296518449046 GO:0030553 cGMP binding 1/492 15/18639 0.0666666666666667 2.52560975609756 0.330628683438819 0.680296518449046 GO:0031005 filamin binding 1/492 15/18639 0.0666666666666667 2.52560975609756 0.330628683438819 0.680296518449046 GO:0031386 protein tag activity 1/492 15/18639 0.0666666666666667 2.52560975609756 0.330628683438819 0.680296518449046 GO:0045504 dynein heavy chain binding 1/492 15/18639 0.0666666666666667 2.52560975609756 0.330628683438819 0.680296518449046 GO:0050700 CARD domain binding 1/492 15/18639 0.0666666666666667 2.52560975609756 0.330628683438819 0.680296518449046 GO:0141047 molecular tag activity 1/492 15/18639 0.0666666666666667 2.52560975609756 0.330628683438819 0.680296518449046 GO:0141050 histone H3K deacetylase activity 1/492 15/18639 0.0666666666666667 2.52560975609756 0.330628683438819 0.680296518449046 GO:0141051 histone H4K deacetylase activity 1/492 15/18639 0.0666666666666667 2.52560975609756 0.330628683438819 0.680296518449046 GO:0141003 histone H2AX kinase activity 11/492 354/18639 0.0310734463276836 1.17719098801157 0.333621912409837 0.680296518449046 GO:0140303 intramembrane lipid transporter activity 2/492 45/18639 0.0444444444444444 1.68373983739837 0.333939348595868 0.680296518449046 GO:0140104 molecular carrier activity 8/492 249/18639 0.0321285140562249 1.21716132823979 0.336584478349088 0.680296518449046 GO:0140996 histone H3 kinase activity 11/492 357/18639 0.030812324929972 1.16729862676778 0.343544347663911 0.680296518449046 GO:0004180 carboxypeptidase activity 2/492 46/18639 0.0434782608695652 1.64713679745493 0.343615657208908 0.680296518449046 GO:0030276 clathrin binding 2/492 46/18639 0.0434782608695652 1.64713679745493 0.343615657208908 0.680296518449046 GO:0030291 protein serine/threonine kinase inhibitor activity 2/492 46/18639 0.0434782608695652 1.64713679745493 0.343615657208908 0.680296518449046 GO:0015085 calcium ion transmembrane transporter activity 5/492 147/18639 0.0340136054421769 1.28857640617222 0.347340306064497 0.680296518449046 GO:0005149 interleukin-1 receptor binding 1/492 16/18639 0.0625 2.36775914634146 0.348311817445912 0.680296518449046 GO:0005159 insulin-like growth factor receptor binding 1/492 16/18639 0.0625 2.36775914634146 0.348311817445912 0.680296518449046 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/492 16/18639 0.0625 2.36775914634146 0.348311817445912 0.680296518449046 GO:0015385 sodium:proton antiporter activity 1/492 16/18639 0.0625 2.36775914634146 0.348311817445912 0.680296518449046 GO:0015562 efflux transmembrane transporter activity 1/492 16/18639 0.0625 2.36775914634146 0.348311817445912 0.680296518449046 GO:0015923 mannosidase activity 1/492 16/18639 0.0625 2.36775914634146 0.348311817445912 0.680296518449046 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/492 16/18639 0.0625 2.36775914634146 0.348311817445912 0.680296518449046 GO:0016722 oxidoreductase activity, acting on metal ions 1/492 16/18639 0.0625 2.36775914634146 0.348311817445912 0.680296518449046 GO:0019841 retinol binding 1/492 16/18639 0.0625 2.36775914634146 0.348311817445912 0.680296518449046 GO:0030275 LRR domain binding 1/492 16/18639 0.0625 2.36775914634146 0.348311817445912 0.680296518449046 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/492 16/18639 0.0625 2.36775914634146 0.348311817445912 0.680296518449046 GO:0140328 floppase activity 1/492 16/18639 0.0625 2.36775914634146 0.348311817445912 0.680296518449046 GO:0001784 phosphotyrosine residue binding 2/492 47/18639 0.0425531914893617 1.61209133367929 0.353246318547171 0.685114300601814 GO:0140359 ABC-type transporter activity 2/492 47/18639 0.0425531914893617 1.61209133367929 0.353246318547171 0.685114300601814 GO:0035173 histone kinase activity 11/492 360/18639 0.0305555555555556 1.15757113821138 0.353518979110536 0.685114300601814 GO:0001221 transcription coregulator binding 4/492 115/18639 0.0347826086956522 1.31770943796394 0.36083671223323 0.690545462063563 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2/492 48/18639 0.0416666666666667 1.57850609756098 0.362827004118602 0.690545462063563 GO:1901981 phosphatidylinositol phosphate binding 6/492 185/18639 0.0324324324324324 1.22867501647989 0.363158848562134 0.690545462063563 GO:0042578 phosphoric ester hydrolase activity 11/492 363/18639 0.0303030303030303 1.1480044345898 0.363538727561215 0.690545462063563 GO:0004549 tRNA-specific ribonuclease activity 1/492 17/18639 0.0588235294117647 2.22847919655667 0.365528731252313 0.690545462063563 GO:0008429 phosphatidylethanolamine binding 1/492 17/18639 0.0588235294117647 2.22847919655667 0.365528731252313 0.690545462063563 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/492 17/18639 0.0588235294117647 2.22847919655667 0.365528731252313 0.690545462063563 GO:0030548 acetylcholine receptor regulator activity 1/492 17/18639 0.0588235294117647 2.22847919655667 0.365528731252313 0.690545462063563 GO:0036041 long-chain fatty acid binding 1/492 17/18639 0.0588235294117647 2.22847919655667 0.365528731252313 0.690545462063563 GO:0070492 oligosaccharide binding 1/492 17/18639 0.0588235294117647 2.22847919655667 0.365528731252313 0.690545462063563 GO:0016763 pentosyltransferase activity 2/492 49/18639 0.0408163265306122 1.54629168740667 0.372353644780197 0.69854588892062 GO:0008234 cysteine-type peptidase activity 6/492 187/18639 0.0320855614973262 1.21553410721273 0.372584752207742 0.69854588892062 GO:0030165 PDZ domain binding 3/492 83/18639 0.036144578313253 1.36930649426976 0.37561711306608 0.69854588892062 GO:0004970 glutamate-gated receptor activity 1/492 18/18639 0.0555555555555556 2.10467479674797 0.382291692492989 0.69854588892062 GO:0008308 voltage-gated monoatomic anion channel activity 1/492 18/18639 0.0555555555555556 2.10467479674797 0.382291692492989 0.69854588892062 GO:0008409 5'-3' exonuclease activity 1/492 18/18639 0.0555555555555556 2.10467479674797 0.382291692492989 0.69854588892062 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/492 18/18639 0.0555555555555556 2.10467479674797 0.382291692492989 0.69854588892062 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/492 18/18639 0.0555555555555556 2.10467479674797 0.382291692492989 0.69854588892062 GO:0032393 MHC class I receptor activity 1/492 18/18639 0.0555555555555556 2.10467479674797 0.382291692492989 0.69854588892062 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/492 18/18639 0.0555555555555556 2.10467479674797 0.382291692492989 0.69854588892062 GO:0099602 neurotransmitter receptor regulator activity 1/492 18/18639 0.0555555555555556 2.10467479674797 0.382291692492989 0.69854588892062 GO:1901611 phosphatidylglycerol binding 1/492 18/18639 0.0555555555555556 2.10467479674797 0.382291692492989 0.69854588892062 GO:0004527 exonuclease activity 3/492 84/18639 0.0357142857142857 1.35300522648084 0.382803147128499 0.69854588892062 GO:0004860 protein kinase inhibitor activity 3/492 84/18639 0.0357142857142857 1.35300522648084 0.382803147128499 0.69854588892062 GO:0019902 phosphatase binding 6/492 190/18639 0.0315789473684211 1.19634146341463 0.3867363938648 0.700139309098154 GO:0005272 sodium channel activity 2/492 51/18639 0.0392156862745098 1.48565279770445 0.3912297481608 0.700139309098154 GO:0016830 carbon-carbon lyase activity 2/492 51/18639 0.0392156862745098 1.48565279770445 0.3912297481608 0.700139309098154 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 3/492 86/18639 0.0348837209302326 1.3215399886557 0.397117009184246 0.700139309098154 GO:0003756 protein disulfide isomerase activity 1/492 19/18639 0.0526315789473684 1.99390243902439 0.398612646646549 0.700139309098154 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/492 19/18639 0.0526315789473684 1.99390243902439 0.398612646646549 0.700139309098154 GO:0005520 insulin-like growth factor binding 1/492 19/18639 0.0526315789473684 1.99390243902439 0.398612646646549 0.700139309098154 GO:0008301 DNA binding, bending 1/492 19/18639 0.0526315789473684 1.99390243902439 0.398612646646549 0.700139309098154 GO:0015245 fatty acid transmembrane transporter activity 1/492 19/18639 0.0526315789473684 1.99390243902439 0.398612646646549 0.700139309098154 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/492 19/18639 0.0526315789473684 1.99390243902439 0.398612646646549 0.700139309098154 GO:0016918 retinal binding 1/492 19/18639 0.0526315789473684 1.99390243902439 0.398612646646549 0.700139309098154 GO:0022821 solute:potassium antiporter activity 1/492 19/18639 0.0526315789473684 1.99390243902439 0.398612646646549 0.700139309098154 GO:0030506 ankyrin binding 1/492 19/18639 0.0526315789473684 1.99390243902439 0.398612646646549 0.700139309098154 GO:0034987 immunoglobulin receptor binding 1/492 19/18639 0.0526315789473684 1.99390243902439 0.398612646646549 0.700139309098154 GO:0042577 lipid phosphatase activity 1/492 19/18639 0.0526315789473684 1.99390243902439 0.398612646646549 0.700139309098154 GO:0050145 nucleoside monophosphate kinase activity 1/492 19/18639 0.0526315789473684 1.99390243902439 0.398612646646549 0.700139309098154 GO:0008236 serine-type peptidase activity 6/492 194/18639 0.0309278350515464 1.17167462911743 0.405600348704612 0.709765797052132 GO:0004864 protein phosphatase inhibitor activity 2/492 53/18639 0.0377358490566038 1.42959042797975 0.409846868044573 0.709765797052132 GO:0005246 calcium channel regulator activity 2/492 53/18639 0.0377358490566038 1.42959042797975 0.409846868044573 0.709765797052132 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 8/492 268/18639 0.0298507462686567 1.13087004004368 0.412530614169548 0.709765797052132 GO:0000339 RNA cap binding 1/492 20/18639 0.05 1.89420731707317 0.414503225478445 0.709765797052132 GO:0001614 purinergic nucleotide receptor activity 1/492 20/18639 0.05 1.89420731707317 0.414503225478445 0.709765797052132 GO:0015095 magnesium ion transmembrane transporter activity 1/492 20/18639 0.05 1.89420731707317 0.414503225478445 0.709765797052132 GO:0016502 nucleotide receptor activity 1/492 20/18639 0.05 1.89420731707317 0.414503225478445 0.709765797052132 GO:0016505 peptidase activator activity involved in apoptotic process 1/492 20/18639 0.05 1.89420731707317 0.414503225478445 0.709765797052132 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/492 20/18639 0.05 1.89420731707317 0.414503225478445 0.709765797052132 GO:0140939 histone H4 methyltransferase activity 1/492 20/18639 0.05 1.89420731707317 0.414503225478445 0.709765797052132 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 3/492 89/18639 0.0337078651685393 1.27699369690326 0.4184130870071 0.713204125580283 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 3/492 89/18639 0.0337078651685393 1.27699369690326 0.4184130870071 0.713204125580283 GO:0017171 serine hydrolase activity 6/492 198/18639 0.0303030303030303 1.1480044345898 0.424419918161472 0.718220637967686 GO:0019210 kinase inhibitor activity 3/492 90/18639 0.0333333333333333 1.26280487804878 0.425457856442051 0.718220637967686 GO:0140793 histone H2AXY142 phosphatase activity 3/492 90/18639 0.0333333333333333 1.26280487804878 0.425457856442051 0.718220637967686 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/492 21/18639 0.0476190476190476 1.80400696864111 0.429974755263321 0.718220637967686 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/492 21/18639 0.0476190476190476 1.80400696864111 0.429974755263321 0.718220637967686 GO:0005123 death receptor binding 1/492 21/18639 0.0476190476190476 1.80400696864111 0.429974755263321 0.718220637967686 GO:0005248 voltage-gated sodium channel activity 1/492 21/18639 0.0476190476190476 1.80400696864111 0.429974755263321 0.718220637967686 GO:0015125 bile acid transmembrane transporter activity 1/492 21/18639 0.0476190476190476 1.80400696864111 0.429974755263321 0.718220637967686 GO:0061891 calcium ion sensor activity 1/492 21/18639 0.0476190476190476 1.80400696864111 0.429974755263321 0.718220637967686 GO:0004519 endonuclease activity 4/492 127/18639 0.031496062992126 1.19320145957365 0.432470813114409 0.719189791977992 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 3/492 91/18639 0.032967032967033 1.24892790136693 0.432472794909433 0.719189791977992 GO:0016829 lyase activity 6/492 200/18639 0.03 1.1365243902439 0.433800344515258 0.719801456607176 GO:0019212 phosphatase inhibitor activity 2/492 56/18639 0.0357142857142857 1.35300522648084 0.43723478812888 0.720716683728922 GO:0030170 pyridoxal phosphate binding 2/492 56/18639 0.0357142857142857 1.35300522648084 0.43723478812888 0.720716683728922 GO:0170055 lipid transmembrane transporter activity 2/492 56/18639 0.0357142857142857 1.35300522648084 0.43723478812888 0.720716683728922 GO:0004407 histone deacetylase activity 1/492 22/18639 0.0454545454545455 1.7220066518847 0.445038264792295 0.724031884152324 GO:0005243 gap junction channel activity 1/492 22/18639 0.0454545454545455 1.7220066518847 0.445038264792295 0.724031884152324 GO:0033558 protein lysine deacetylase activity 1/492 22/18639 0.0454545454545455 1.7220066518847 0.445038264792295 0.724031884152324 GO:0033691 sialic acid binding 1/492 22/18639 0.0454545454545455 1.7220066518847 0.445038264792295 0.724031884152324 GO:0061133 endopeptidase activator activity 1/492 22/18639 0.0454545454545455 1.7220066518847 0.445038264792295 0.724031884152324 GO:0140784 metal ion sensor activity 1/492 22/18639 0.0454545454545455 1.7220066518847 0.445038264792295 0.724031884152324 GO:0070279 vitamin B6 binding 2/492 57/18639 0.0350877192982456 1.32926829268293 0.446210364392221 0.724367474662696 GO:0003714 transcription corepressor activity 6/492 204/18639 0.0294117647058824 1.11423959827834 0.452478211638316 0.731254118431742 GO:0061980 regulatory RNA binding 2/492 58/18639 0.0344827586206897 1.30634987384357 0.455105309931023 0.731254118431742 GO:0005262 calcium channel activity 4/492 131/18639 0.0305343511450382 1.15676782722026 0.455919325997745 0.731254118431742 GO:0004602 glutathione peroxidase activity 1/492 23/18639 0.0434782608695652 1.64713679745493 0.459704493170777 0.731254118431742 GO:0042171 lysophosphatidic acid acyltransferase activity 1/492 23/18639 0.0434782608695652 1.64713679745493 0.459704493170777 0.731254118431742 GO:0043274 phospholipase binding 1/492 23/18639 0.0434782608695652 1.64713679745493 0.459704493170777 0.731254118431742 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/492 23/18639 0.0434782608695652 1.64713679745493 0.459704493170777 0.731254118431742 GO:0071617 lysophospholipid acyltransferase activity 1/492 23/18639 0.0434782608695652 1.64713679745493 0.459704493170777 0.731254118431742 GO:0099186 structural constituent of postsynapse 1/492 23/18639 0.0434782608695652 1.64713679745493 0.459704493170777 0.731254118431742 GO:0004867 serine-type endopeptidase inhibitor activity 3/492 95/18639 0.0315789473684211 1.19634146341463 0.460202591866376 0.731254118431742 GO:0004879 nuclear receptor activity 2/492 59/18639 0.0338983050847458 1.28420835055808 0.463917623079678 0.731456631809087 GO:0015459 potassium channel regulator activity 2/492 59/18639 0.0338983050847458 1.28420835055808 0.463917623079678 0.731456631809087 GO:0045309 protein phosphorylated amino acid binding 2/492 59/18639 0.0338983050847458 1.28420835055808 0.463917623079678 0.731456631809087 GO:0005516 calmodulin binding 6/492 207/18639 0.0289855072463768 1.09809119830329 0.46639577405499 0.731456631809087 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 2/492 60/18639 0.0333333333333333 1.26280487804878 0.472645463496412 0.731456631809087 GO:0098531 ligand-modulated transcription factor activity 2/492 60/18639 0.0333333333333333 1.26280487804878 0.472645463496412 0.731456631809087 GO:0051087 protein-folding chaperone binding 4/492 134/18639 0.0298507462686567 1.13087004004368 0.47329212248018 0.731456631809087 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/492 24/18639 0.0416666666666667 1.57850609756098 0.473983897412288 0.731456631809087 GO:0004622 lysophospholipase activity 1/492 24/18639 0.0416666666666667 1.57850609756098 0.473983897412288 0.731456631809087 GO:0030215 semaphorin receptor binding 1/492 24/18639 0.0416666666666667 1.57850609756098 0.473983897412288 0.731456631809087 GO:0035035 histone acetyltransferase binding 1/492 24/18639 0.0416666666666667 1.57850609756098 0.473983897412288 0.731456631809087 GO:0050431 transforming growth factor beta binding 1/492 24/18639 0.0416666666666667 1.57850609756098 0.473983897412288 0.731456631809087 GO:0070300 phosphatidic acid binding 1/492 24/18639 0.0416666666666667 1.57850609756098 0.473983897412288 0.731456631809087 GO:0070840 dynein complex binding 1/492 24/18639 0.0416666666666667 1.57850609756098 0.473983897412288 0.731456631809087 GO:0004725 protein tyrosine phosphatase activity 3/492 98/18639 0.0306122448979592 1.159718765555 0.480612942890624 0.736663997559632 GO:0008170 N-methyltransferase activity 3/492 98/18639 0.0306122448979592 1.159718765555 0.480612942890624 0.736663997559632 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 2/492 61/18639 0.0327868852459016 1.24210315873651 0.481287145072293 0.736663997559632 GO:0016836 hydro-lyase activity 2/492 61/18639 0.0327868852459016 1.24210315873651 0.481287145072293 0.736663997559632 GO:0003707 nuclear steroid receptor activity 1/492 25/18639 0.04 1.51536585365854 0.487886659833623 0.73883501265696 GO:0005251 delayed rectifier potassium channel activity 1/492 25/18639 0.04 1.51536585365854 0.487886659833623 0.73883501265696 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/492 25/18639 0.04 1.51536585365854 0.487886659833623 0.73883501265696 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/492 25/18639 0.04 1.51536585365854 0.487886659833623 0.73883501265696 GO:0019707 protein-cysteine S-acyltransferase activity 1/492 25/18639 0.04 1.51536585365854 0.487886659833623 0.73883501265696 GO:0004252 serine-type endopeptidase activity 5/492 176/18639 0.0284090909090909 1.07625415742794 0.497482757330132 0.73883501265696 GO:1901682 sulfur compound transmembrane transporter activity 2/492 63/18639 0.0317460317460317 1.20267131242741 0.498306017699965 0.73883501265696 GO:0001637 G protein-coupled chemoattractant receptor activity 1/492 26/18639 0.0384615384615385 1.45708255159475 0.501422695256523 0.73883501265696 GO:0004529 DNA exonuclease activity 1/492 26/18639 0.0384615384615385 1.45708255159475 0.501422695256523 0.73883501265696 GO:0004950 chemokine receptor activity 1/492 26/18639 0.0384615384615385 1.45708255159475 0.501422695256523 0.73883501265696 GO:0005112 Notch binding 1/492 26/18639 0.0384615384615385 1.45708255159475 0.501422695256523 0.73883501265696 GO:0008066 glutamate receptor activity 1/492 26/18639 0.0384615384615385 1.45708255159475 0.501422695256523 0.73883501265696 GO:0008143 poly(A) binding 1/492 26/18639 0.0384615384615385 1.45708255159475 0.501422695256523 0.73883501265696 GO:0030507 spectrin binding 1/492 26/18639 0.0384615384615385 1.45708255159475 0.501422695256523 0.73883501265696 GO:0034237 protein kinase A regulatory subunit binding 1/492 26/18639 0.0384615384615385 1.45708255159475 0.501422695256523 0.73883501265696 GO:0050681 nuclear androgen receptor binding 1/492 26/18639 0.0384615384615385 1.45708255159475 0.501422695256523 0.73883501265696 GO:0051139 metal cation:proton antiporter activity 1/492 26/18639 0.0384615384615385 1.45708255159475 0.501422695256523 0.73883501265696 GO:0070412 R-SMAD binding 1/492 26/18639 0.0384615384615385 1.45708255159475 0.501422695256523 0.73883501265696 GO:0120014 phospholipid transfer activity 1/492 26/18639 0.0384615384615385 1.45708255159475 0.501422695256523 0.73883501265696 GO:0004175 endopeptidase activity 11/492 405/18639 0.0271604938271605 1.02895212285456 0.504722247292011 0.74223859895884 GO:0004536 DNA nuclease activity 2/492 64/18639 0.03125 1.18387957317073 0.506680547476297 0.743035018609188 GO:0008238 exopeptidase activity 3/492 102/18639 0.0294117647058824 1.11423959827834 0.507245239370539 0.743035018609188 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/492 27/18639 0.037037037037037 1.40311653116531 0.514601658020924 0.743644014481104 GO:0008266 poly(U) RNA binding 1/492 27/18639 0.037037037037037 1.40311653116531 0.514601658020924 0.743644014481104 GO:0008320 protein transmembrane transporter activity 1/492 27/18639 0.037037037037037 1.40311653116531 0.514601658020924 0.743644014481104 GO:0008395 steroid hydroxylase activity 1/492 27/18639 0.037037037037037 1.40311653116531 0.514601658020924 0.743644014481104 GO:0015252 proton channel activity 1/492 27/18639 0.037037037037037 1.40311653116531 0.514601658020924 0.743644014481104 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/492 27/18639 0.037037037037037 1.40311653116531 0.514601658020924 0.743644014481104 GO:0035255 ionotropic glutamate receptor binding 1/492 27/18639 0.037037037037037 1.40311653116531 0.514601658020924 0.743644014481104 GO:0046873 metal ion transmembrane transporter activity 12/492 450/18639 0.0266666666666667 1.01024390243902 0.526996683228915 0.757805960940656 GO:0051019 mitogen-activated protein kinase binding 1/492 28/18639 0.0357142857142857 1.35300522648084 0.527432948814697 0.757805960940656 GO:0051393 alpha-actinin binding 1/492 28/18639 0.0357142857142857 1.35300522648084 0.527432948814697 0.757805960940656 GO:0004497 monooxygenase activity 3/492 106/18639 0.0283018867924528 1.07219282098481 0.533149979532589 0.764555419979812 GO:0005548 phospholipid transporter activity 2/492 68/18639 0.0294117647058824 1.11423959827834 0.539254182322536 0.769856066527576 GO:0016417 S-acyltransferase activity 1/492 29/18639 0.0344827586206897 1.30634987384357 0.539925721324674 0.769856066527576 GO:0043236 laminin binding 1/492 29/18639 0.0344827586206897 1.30634987384357 0.539925721324674 0.769856066527576 GO:0004620 phospholipase activity 3/492 109/18639 0.0275229357798165 1.04268292682927 0.552066523198836 0.781257861387195 GO:0008187 poly-pyrimidine tract binding 1/492 30/18639 0.0333333333333333 1.26280487804878 0.552088888713618 0.781257861387195 GO:0016769 transferase activity, transferring nitrogenous groups 1/492 30/18639 0.0333333333333333 1.26280487804878 0.552088888713618 0.781257861387195 GO:0098918 structural constituent of synapse 1/492 30/18639 0.0333333333333333 1.26280487804878 0.552088888713618 0.781257861387195 GO:0008028 monocarboxylic acid transmembrane transporter activity 2/492 70/18639 0.0285714285714286 1.08240418118467 0.554974896123405 0.783862847631928 GO:0019842 vitamin binding 4/492 150/18639 0.0266666666666667 1.01024390243902 0.561855139494464 0.785374623152644 GO:0140299 molecular sensor activity 2/492 71/18639 0.028169014084507 1.06715905187221 0.562691610932128 0.785374623152644 GO:0005164 tumor necrosis factor receptor binding 1/492 31/18639 0.032258064516129 1.2220692368214 0.563931129927703 0.785374623152644 GO:0005184 neuropeptide hormone activity 1/492 31/18639 0.032258064516129 1.2220692368214 0.563931129927703 0.785374623152644 GO:0016411 acylglycerol O-acyltransferase activity 1/492 31/18639 0.032258064516129 1.2220692368214 0.563931129927703 0.785374623152644 GO:0047499 calcium-independent phospholipase A2 activity 1/492 31/18639 0.032258064516129 1.2220692368214 0.563931129927703 0.785374623152644 GO:0072349 modified amino acid transmembrane transporter activity 1/492 31/18639 0.032258064516129 1.2220692368214 0.563931129927703 0.785374623152644 GO:1902936 phosphatidylinositol bisphosphate binding 3/492 111/18639 0.027027027027027 1.02389584706658 0.5644225625057 0.785374623152644 GO:0022884 macromolecule transmembrane transporter activity 1/492 32/18639 0.03125 1.18387957317073 0.575460895838901 0.790468263514973 GO:0031369 translation initiation factor binding 1/492 32/18639 0.03125 1.18387957317073 0.575460895838901 0.790468263514973 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/492 32/18639 0.03125 1.18387957317073 0.575460895838901 0.790468263514973 GO:0042910 xenobiotic transmembrane transporter activity 1/492 32/18639 0.03125 1.18387957317073 0.575460895838901 0.790468263514973 GO:0047498 calcium-dependent phospholipase A2 activity 1/492 32/18639 0.03125 1.18387957317073 0.575460895838901 0.790468263514973 GO:0070717 poly-purine tract binding 1/492 32/18639 0.03125 1.18387957317073 0.575460895838901 0.790468263514973 GO:0160041 neuropeptide activity 1/492 32/18639 0.03125 1.18387957317073 0.575460895838901 0.790468263514973 GO:0004521 RNA endonuclease activity 2/492 73/18639 0.0273972602739726 1.03792181757434 0.577835807248864 0.792279443211422 GO:0019956 chemokine binding 1/492 33/18639 0.0303030303030303 1.1480044345898 0.586686415226618 0.801484173806855 GO:0071889 14-3-3 protein binding 1/492 33/18639 0.0303030303030303 1.1480044345898 0.586686415226618 0.801484173806855 GO:0017124 SH3 domain binding 3/492 115/18639 0.0260869565217391 0.988282078472959 0.588500915412978 0.802501248290424 GO:0003725 double-stranded RNA binding 2/492 75/18639 0.0266666666666667 1.01024390243902 0.592592757408221 0.806614461081971 GO:0015035 protein-disulfide reductase activity 1/492 34/18639 0.0294117647058824 1.11423959827834 0.59761570060276 0.807588784598325 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/492 34/18639 0.0294117647058824 1.11423959827834 0.59761570060276 0.807588784598325 GO:0051427 hormone receptor binding 1/492 34/18639 0.0294117647058824 1.11423959827834 0.59761570060276 0.807588784598325 GO:0090482 vitamin transmembrane transporter activity 1/492 34/18639 0.0294117647058824 1.11423959827834 0.59761570060276 0.807588784598325 GO:1990782 protein tyrosine kinase binding 3/492 117/18639 0.0256410256410256 0.971388367729831 0.600215331014339 0.809642982483371 GO:0004623 phospholipase A2 activity 1/492 35/18639 0.0285714285714286 1.08240418118467 0.608256553884321 0.817549131564948 GO:0016229 steroid dehydrogenase activity 1/492 35/18639 0.0285714285714286 1.08240418118467 0.608256553884321 0.817549131564948 GO:0016409 palmitoyltransferase activity 1/492 36/18639 0.0277777777777778 1.05233739837398 0.618616571917482 0.828504337389484 GO:0045505 dynein intermediate chain binding 1/492 36/18639 0.0277777777777778 1.05233739837398 0.618616571917482 0.828504337389484 GO:0016835 carbon-oxygen lyase activity 2/492 79/18639 0.0253164556962025 0.959092312442112 0.620942731045316 0.830137340969674 GO:0004540 RNA nuclease activity 3/492 121/18639 0.0247933884297521 0.939276355573473 0.622979352011574 0.831378138805481 GO:0019213 deacetylase activity 1/492 37/18639 0.027027027027027 1.02389584706658 0.628703151857093 0.834561706004991 GO:0030280 structural constituent of skin epidermis 1/492 37/18639 0.027027027027027 1.02389584706658 0.628703151857093 0.834561706004991 GO:0030551 cyclic nucleotide binding 1/492 37/18639 0.027027027027027 1.02389584706658 0.628703151857093 0.834561706004991 GO:0015081 sodium ion transmembrane transporter activity 4/492 164/18639 0.024390243902439 0.924003569303986 0.632244665148486 0.837780033323965 GO:0015101 organic cation transmembrane transporter activity 2/492 81/18639 0.0246913580246914 0.935411020776874 0.634537382971034 0.837857459908936 GO:0030971 receptor tyrosine kinase binding 2/492 81/18639 0.0246913580246914 0.935411020776874 0.634537382971034 0.837857459908936 GO:0000146 microfilament motor activity 1/492 38/18639 0.0263157894736842 0.996951219512195 0.638523496405331 0.839643922717096 GO:0042887 amide transmembrane transporter activity 1/492 38/18639 0.0263157894736842 0.996951219512195 0.638523496405331 0.839643922717096 GO:0005216 monoatomic ion channel activity 11/492 448/18639 0.0245535714285714 0.930191093205575 0.639248906495282 0.839643922717096 GO:0005254 chloride channel activity 2/492 83/18639 0.0240963855421687 0.912870996179841 0.647747823397202 0.846800460252418 GO:0000217 DNA secondary structure binding 1/492 39/18639 0.0256410256410256 0.971388367729831 0.648084618913184 0.846800460252418 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/492 39/18639 0.0256410256410256 0.971388367729831 0.648084618913184 0.846800460252418 GO:0051117 ATPase binding 2/492 84/18639 0.0238095238095238 0.902003484320557 0.654209888672048 0.853317246093976 GO:0015036 disulfide oxidoreductase activity 1/492 40/18639 0.025 0.947103658536585 0.657393348348384 0.854497419863584 GO:0030331 nuclear estrogen receptor binding 1/492 40/18639 0.025 0.947103658536585 0.657393348348384 0.854497419863584 GO:0008227 G protein-coupled amine receptor activity 1/492 41/18639 0.024390243902439 0.924003569303986 0.666456334133243 0.860313684337232 GO:0042169 SH2 domain binding 1/492 41/18639 0.024390243902439 0.924003569303986 0.666456334133243 0.860313684337232 GO:0042287 MHC protein binding 1/492 41/18639 0.024390243902439 0.924003569303986 0.666456334133243 0.860313684337232 GO:0140318 protein transporter activity 1/492 41/18639 0.024390243902439 0.924003569303986 0.666456334133243 0.860313684337232 GO:0016298 lipase activity 3/492 130/18639 0.0230769230769231 0.874249530956848 0.670891530754688 0.862793932098574 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3/492 130/18639 0.0230769230769231 0.874249530956848 0.670891530754688 0.862793932098574 GO:0016741 transferase activity, transferring one-carbon groups 5/492 215/18639 0.0232558139534884 0.8810266591038 0.67387996787193 0.862793932098574 GO:0004520 DNA endonuclease activity 1/492 42/18639 0.0238095238095238 0.902003484320557 0.675280050855817 0.862793932098574 GO:0031492 nucleosomal DNA binding 1/492 42/18639 0.0238095238095238 0.902003484320557 0.675280050855817 0.862793932098574 GO:0035198 miRNA binding 1/492 42/18639 0.0238095238095238 0.902003484320557 0.675280050855817 0.862793932098574 GO:0005261 monoatomic cation channel activity 8/492 341/18639 0.0234604105571848 0.8887776267792 0.681532666302793 0.868187368772962 GO:0004721 phosphoprotein phosphatase activity 4/492 175/18639 0.0228571428571429 0.865923344947735 0.682177012234167 0.868187368772962 GO:0008200 ion channel inhibitor activity 1/492 43/18639 0.0232558139534884 0.8810266591038 0.683870802857696 0.868187368772962 GO:0003727 single-stranded RNA binding 2/492 89/18639 0.0224719101123595 0.851329131268841 0.685107929901671 0.868187368772962 GO:0015631 tubulin binding 9/492 385/18639 0.0233766233766234 0.885603420969275 0.690793033558437 0.868187368772962 GO:0001046 core promoter sequence-specific DNA binding 1/492 44/18639 0.0227272727272727 0.86100332594235 0.692234728701642 0.868187368772962 GO:0001223 transcription coactivator binding 1/492 44/18639 0.0227272727272727 0.86100332594235 0.692234728701642 0.868187368772962 GO:0016248 channel inhibitor activity 1/492 44/18639 0.0227272727272727 0.86100332594235 0.692234728701642 0.868187368772962 GO:0016790 thiolester hydrolase activity 1/492 44/18639 0.0227272727272727 0.86100332594235 0.692234728701642 0.868187368772962 GO:0019205 nucleobase-containing compound kinase activity 1/492 44/18639 0.0227272727272727 0.86100332594235 0.692234728701642 0.868187368772962 GO:0030547 signaling receptor inhibitor activity 1/492 44/18639 0.0227272727272727 0.86100332594235 0.692234728701642 0.868187368772962 GO:0003730 mRNA 3'-UTR binding 6/492 262/18639 0.0229007633587786 0.867575870415193 0.693532956713964 0.868363468339688 GO:0015297 antiporter activity 3/492 135/18639 0.0222222222222222 0.841869918699187 0.695513611795925 0.869392014744907 GO:0099094 ligand-gated monoatomic cation channel activity 3/492 136/18639 0.0220588235294118 0.835679698708752 0.700267497141206 0.869674427386872 GO:0140789 histone phosphatase activity 3/492 136/18639 0.0220588235294118 0.835679698708752 0.700267497141206 0.869674427386872 GO:0042605 peptide antigen binding 1/492 45/18639 0.0222222222222222 0.841869918699187 0.700377805522228 0.869674427386872 GO:0141110 transporter inhibitor activity 1/492 45/18639 0.0222222222222222 0.841869918699187 0.700377805522228 0.869674427386872 GO:0016853 isomerase activity 4/492 180/18639 0.0222222222222222 0.841869918699187 0.703242749021561 0.871788531844911 GO:0016922 nuclear receptor binding 3/492 137/18639 0.0218978102189781 0.829579846893359 0.704964824449542 0.872481218378146 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 4/492 181/18639 0.0220994475138122 0.83721870367875 0.707332753927302 0.873969630058445 GO:0043495 protein-membrane adaptor activity 1/492 47/18639 0.0212765957446809 0.806045666839647 0.716024538799814 0.883253954111612 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/492 48/18639 0.0208333333333333 0.789253048780488 0.723539379963244 0.889597598315464 GO:0140693 molecular condensate scaffold activity 1/492 48/18639 0.0208333333333333 0.789253048780488 0.723539379963244 0.889597598315464 GO:0015276 ligand-gated monoatomic ion channel activity 4/492 186/18639 0.021505376344086 0.8147128245476 0.727168290433989 0.892596101187384 GO:0016791 phosphatase activity 6/492 273/18639 0.021978021978022 0.832618600911284 0.730340309311189 0.892739107629753 GO:0001222 transcription corepressor binding 1/492 49/18639 0.0204081632653061 0.773145843703335 0.730855749446224 0.892739107629753 GO:0035254 glutamate receptor binding 1/492 49/18639 0.0204081632653061 0.773145843703335 0.730855749446224 0.892739107629753 GO:0022834 ligand-gated channel activity 4/492 188/18639 0.0212765957446809 0.806045666839647 0.734816849672459 0.893426262657521 GO:0046943 carboxylic acid transmembrane transporter activity 4/492 188/18639 0.0212765957446809 0.806045666839647 0.734816849672459 0.893426262657521 GO:0042626 ATPase-coupled transmembrane transporter activity 2/492 98/18639 0.0204081632653061 0.773145843703335 0.73499200541292 0.893426262657521 GO:0032813 tumor necrosis factor receptor superfamily binding 1/492 50/18639 0.02 0.757682926829268 0.73797887861634 0.893443849340354 GO:0022836 gated channel activity 7/492 318/18639 0.0220125786163522 0.833927749654855 0.738126587177791 0.893443849340354 GO:0005342 organic acid transmembrane transporter activity 4/492 189/18639 0.0211640211640212 0.801780874951607 0.738580248788026 0.893443849340354 GO:0030544 Hsp70 protein binding 1/492 51/18639 0.0196078431372549 0.742826398852224 0.744913861225451 0.899654421769868 GO:0015171 amino acid transmembrane transporter activity 2/492 102/18639 0.0196078431372549 0.742826398852224 0.754915426198171 0.906984563722679 GO:0005544 calcium-dependent phospholipid binding 1/492 53/18639 0.0188679245283019 0.714795213989876 0.758239095272159 0.906984563722679 GO:0008146 sulfotransferase activity 1/492 53/18639 0.0188679245283019 0.714795213989876 0.758239095272159 0.906984563722679 GO:0051018 protein kinase A binding 1/492 53/18639 0.0188679245283019 0.714795213989876 0.758239095272159 0.906984563722679 GO:0140296 general transcription initiation factor binding 1/492 53/18639 0.0188679245283019 0.714795213989876 0.758239095272159 0.906984563722679 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/492 53/18639 0.0188679245283019 0.714795213989876 0.758239095272159 0.906984563722679 GO:0005253 monoatomic anion channel activity 2/492 103/18639 0.0194174757281553 0.735614492067251 0.759690146344902 0.907273263946937 GO:0003712 transcription coregulator activity 11/492 495/18639 0.0222222222222222 0.841869918699187 0.760907210354936 0.907282047323055 GO:0140463 chromatin-protein adaptor activity 1/492 54/18639 0.0185185185185185 0.701558265582656 0.764638878180052 0.910284378785777 GO:0008374 O-acyltransferase activity 1/492 55/18639 0.0181818181818182 0.68880266075388 0.770869584229846 0.916247524837376 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/492 56/18639 0.0178571428571429 0.676502613240418 0.776935671431682 0.921996445528103 GO:0008168 methyltransferase activity 4/492 204/18639 0.0196078431372549 0.742826398852224 0.790257960389083 0.935615667133579 GO:0004222 metalloendopeptidase activity 2/492 110/18639 0.0181818181818182 0.68880266075388 0.790907110616919 0.935615667133579 GO:0015079 potassium ion transmembrane transporter activity 3/492 160/18639 0.01875 0.710327743902439 0.797952524909561 0.940014439954519 GO:0001098 basal transcription machinery binding 1/492 60/18639 0.0166666666666667 0.63140243902439 0.799638950254644 0.940014439954519 GO:0001099 basal RNA polymerase II transcription machinery binding 1/492 60/18639 0.0166666666666667 0.63140243902439 0.799638950254644 0.940014439954519 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/492 60/18639 0.0166666666666667 0.63140243902439 0.799638950254644 0.940014439954519 GO:0003713 transcription coactivator activity 5/492 256/18639 0.01953125 0.739924733231707 0.809334356392066 0.949348181071506 GO:0015179 L-amino acid transmembrane transporter activity 1/492 62/18639 0.0161290322580645 0.6110346184107 0.810110447847685 0.949348181071506 GO:0022824 transmitter-gated monoatomic ion channel activity 1/492 63/18639 0.0158730158730159 0.601335656213705 0.815139551559745 0.952265831261385 GO:0022835 transmitter-gated channel activity 1/492 63/18639 0.0158730158730159 0.601335656213705 0.815139551559745 0.952265831261385 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 3/492 167/18639 0.0179640718562874 0.680553527092157 0.820892337907064 0.957494950902486 GO:0160215 deacylase activity 1/492 65/18639 0.0153846153846154 0.582833020637899 0.824802478459013 0.96056189261531 GO:0015108 chloride transmembrane transporter activity 2/492 121/18639 0.0165289256198347 0.626184237048982 0.832755329300002 0.966490208052328 GO:0042054 histone methyltransferase activity 1/492 67/18639 0.0149253731343284 0.565435020021842 0.833961282872053 0.966490208052328 GO:0008528 G protein-coupled peptide receptor activity 2/492 122/18639 0.0163934426229508 0.621051579368253 0.836159081791772 0.966490208052328 GO:0030145 manganese ion binding 1/492 68/18639 0.0147058823529412 0.557119799139168 0.838359896313091 0.966490208052328 GO:0005244 voltage-gated monoatomic ion channel activity 3/492 173/18639 0.0173410404624277 0.656950514591851 0.838755397294415 0.966490208052328 GO:0008514 organic anion transmembrane transporter activity 5/492 269/18639 0.0185873605947955 0.704166288874785 0.84154518751558 0.966490208052328 GO:0003823 antigen binding 3/492 174/18639 0.0172413793103448 0.653174936921783 0.84157845997232 0.966490208052328 GO:0016279 protein-lysine N-methyltransferase activity 1/492 69/18639 0.0144927536231884 0.549045599151644 0.842642214498108 0.966490208052328 GO:0098960 postsynaptic neurotransmitter receptor activity 1/492 69/18639 0.0144927536231884 0.549045599151644 0.842642214498108 0.966490208052328 GO:0005267 potassium channel activity 2/492 124/18639 0.0161290322580645 0.6110346184107 0.84277946142163 0.966490208052328 GO:0022832 voltage-gated channel activity 3/492 175/18639 0.0171428571428571 0.649442508710801 0.844358717781706 0.966679573137849 GO:0016278 lysine N-methyltransferase activity 1/492 70/18639 0.0142857142857143 0.541202090592334 0.846811306068756 0.966679573137849 GO:0016782 transferase activity, transferring sulphur-containing groups 1/492 70/18639 0.0142857142857143 0.541202090592334 0.846811306068756 0.966679573137849 GO:0001653 peptide receptor activity 2/492 128/18639 0.015625 0.591939786585366 0.85529754682613 0.972811980412798 GO:0031490 chromatin DNA binding 2/492 128/18639 0.015625 0.591939786585366 0.85529754682613 0.972811980412798 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4/492 229/18639 0.0174672489082969 0.661731813824688 0.857901317735948 0.972811980412798 GO:0046982 protein heterodimerization activity 7/492 369/18639 0.018970189701897 0.718669442791989 0.858666876583136 0.972811980412798 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/492 73/18639 0.0136986301369863 0.51896090878717 0.858668708044363 0.972811980412798 GO:0000287 magnesium ion binding 4/492 230/18639 0.0173913043478261 0.658854718981972 0.860171339727826 0.973044501954554 GO:0031491 nucleosome binding 1/492 74/18639 0.0135135135135135 0.511947923533289 0.862413994893559 0.974112193027364 GO:0017022 myosin binding 1/492 76/18639 0.0131578947368421 0.498475609756098 0.869610021406478 0.980763182037381 GO:0016779 nucleotidyltransferase activity 2/492 136/18639 0.0147058823529412 0.557119799139168 0.87764432813334 0.987967215258668 GO:0015291 secondary active transmembrane transporter activity 5/492 287/18639 0.0174216027874564 0.660002549502847 0.878632176770043 0.987967215258668 GO:0140767 enzyme-substrate adaptor activity 2/492 139/18639 0.0143884892086331 0.545095630812423 0.885171477771955 0.99383025198947 GO:0019903 protein phosphatase binding 2/492 144/18639 0.0138888888888889 0.526168699186992 0.896771107477294 0.999860922248685 GO:0050660 flavin adenine dinucleotide binding 1/492 86/18639 0.0116279069767442 0.4405133295519 0.90033199788176 0.999860922248685 GO:0031625 ubiquitin protein ligase binding 5/492 302/18639 0.0165562913907285 0.627220965918268 0.903642768087416 0.999860922248685 GO:0008509 monoatomic anion transmembrane transporter activity 2/492 149/18639 0.0134228187919463 0.508512031429039 0.907273242804694 0.999860922248685 GO:0052689 carboxylic ester hydrolase activity 1/492 92/18639 0.0108695652173913 0.411784199363733 0.915177303570101 0.999860922248685 GO:0016410 N-acyltransferase activity 1/492 94/18639 0.0106382978723404 0.403022833419824 0.919617950053568 0.999860922248685 GO:0008276 protein methyltransferase activity 1/492 95/18639 0.0105263157894737 0.398780487804878 0.921750490823244 0.999860922248685 GO:0016407 acetyltransferase activity 1/492 96/18639 0.0104166666666667 0.394626524390244 0.923826567102093 0.999860922248685 GO:0030594 neurotransmitter receptor activity 1/492 97/18639 0.0103092783505155 0.390558209705808 0.925847670968013 0.999860922248685 GO:0005249 voltage-gated potassium channel activity 1/492 98/18639 0.0102040816326531 0.386572921851667 0.927815255148994 0.999860922248685 GO:0044389 ubiquitin-like protein ligase binding 5/492 322/18639 0.015527950310559 0.58826314194819 0.9299461243649 0.999860922248685 GO:0015103 inorganic anion transmembrane transporter activity 2/492 165/18639 0.0121212121212121 0.45920177383592 0.934542837357911 0.999860922248685 GO:0008017 microtubule binding 4/492 276/18639 0.0144927536231884 0.549045599151644 0.935828834113863 0.999860922248685 GO:0016874 ligase activity 2/492 167/18639 0.0119760479041916 0.453702351394771 0.937361902570444 0.999860922248685 GO:0004674 protein serine/threonine kinase activity 7/492 433/18639 0.0161662817551963 0.612445783811187 0.941896722001403 0.999860922248685 GO:0140030 modification-dependent protein binding 2/492 173/18639 0.0115606936416185 0.437967009727901 0.9451445307846 0.999860922248685 GO:0043021 ribonucleoprotein complex binding 2/492 177/18639 0.0112994350282486 0.428069450186027 0.949812411875167 0.999860922248685 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 3/492 243/18639 0.0123456790123457 0.467705510388437 0.957063766321882 0.999860922248685 GO:0008237 metallopeptidase activity 2/492 184/18639 0.0108695652173913 0.411784199363733 0.957084092932082 0.999860922248685 GO:0004676 3-phosphoinositide-dependent protein kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:0004711 ribosomal protein S6 kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:0035175 histone H3S10 kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:0035979 histone H2AXS139 kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:0044022 histone H3S28 kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:0044023 histone H4S1 kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:0044024 histone H2AS1 kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:0044025 histone H2BS14 kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:0072354 histone H3T3 kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:0072371 histone H2AS121 kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:0072518 Rho-dependent protein serine/threonine kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:0140823 histone H2BS36 kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:0140855 histone H3S57 kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:0140995 histone H2A kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:0140997 histone H4 kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:0140998 histone H2B kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:1990244 histone H2AT120 kinase activity 3/492 245/18639 0.0122448979591837 0.463887506222001 0.958746697967027 0.999860922248685 GO:0004677 DNA-dependent protein kinase activity 3/492 246/18639 0.0121951219512195 0.462001784651993 0.95956480862508 0.999860922248685 GO:0140857 histone H3T45 kinase activity 3/492 246/18639 0.0121951219512195 0.462001784651993 0.95956480862508 0.999860922248685 GO:0035402 histone H3T11 kinase activity 3/492 247/18639 0.0121457489878543 0.460131332082552 0.960367696371167 0.999860922248685 GO:0035403 histone H3T6 kinase activity 3/492 247/18639 0.0121457489878543 0.460131332082552 0.960367696371167 0.999860922248685 GO:0003697 single-stranded DNA binding 1/492 121/18639 0.00826446280991736 0.313092118524491 0.961127403928508 0.999860922248685 GO:0051082 unfolded protein binding 1/492 121/18639 0.00826446280991736 0.313092118524491 0.961127403928508 0.999860922248685 GO:0004679 AMP-activated protein kinase activity 3/492 248/18639 0.0120967741935484 0.458275963808025 0.961155617146746 0.999860922248685 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/492 122/18639 0.00819672131147541 0.310525789684126 0.962160199979225 0.999860922248685 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 1/492 122/18639 0.00819672131147541 0.310525789684126 0.962160199979225 0.999860922248685 GO:0016887 ATP hydrolysis activity 6/492 417/18639 0.0143884892086331 0.545095630812423 0.96586039866056 0.999860922248685 GO:0035591 signaling adaptor activity 1/492 129/18639 0.00775193798449612 0.2936755530346 0.968662242663656 0.999860922248685 GO:0031072 heat shock protein binding 1/492 131/18639 0.00763358778625954 0.289191956805064 0.970306075481287 0.999860922248685 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 1/492 132/18639 0.00757575757575758 0.28700110864745 0.971095432022415 0.999860922248685 GO:0016757 glycosyltransferase activity 3/492 267/18639 0.0112359550561798 0.42566456563442 0.973597649120728 0.999860922248685 GO:0140101 catalytic activity, acting on a tRNA 1/492 139/18639 0.00719424460431655 0.272547815406212 0.976064598807773 0.999860922248685 GO:0003924 GTPase activity 4/492 331/18639 0.0120845921450151 0.457814457298652 0.976684679836623 0.999860922248685 GO:0022843 voltage-gated monoatomic cation channel activity 1/492 143/18639 0.00699300699300699 0.264924100289954 0.978511214197767 0.999860922248685 GO:0008194 UDP-glycosyltransferase activity 1/492 145/18639 0.00689655172413793 0.261269974768713 0.979639257556751 0.999860922248685 GO:0019001 guanyl nucleotide binding 5/492 400/18639 0.0125 0.473551829268293 0.981766560728455 0.999860922248685 GO:0032561 guanyl ribonucleotide binding 5/492 400/18639 0.0125 0.473551829268293 0.981766560728455 0.999860922248685 GO:0000510 H3-H4 histone complex chaperone activity 1/492 151/18639 0.00662251655629139 0.250888386367307 0.982680976328712 0.999860922248685 GO:0140584 chromatin extrusion motor activity 1/492 151/18639 0.00662251655629139 0.250888386367307 0.982680976328712 0.999860922248685 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 1/492 151/18639 0.00662251655629139 0.250888386367307 0.982680976328712 0.999860922248685 GO:0140849 ATP-dependent H2AZ histone chaperone activity 1/492 151/18639 0.00662251655629139 0.250888386367307 0.982680976328712 0.999860922248685 GO:0015616 DNA translocase activity 1/492 152/18639 0.00657894736842105 0.249237804878049 0.983141867698589 0.999860922248685 GO:0140674 ATP-dependent histone chaperone activity 1/492 152/18639 0.00657894736842105 0.249237804878049 0.983141867698589 0.999860922248685 GO:0003774 cytoskeletal motor activity 1/492 153/18639 0.0065359477124183 0.247608799617408 0.983590518160659 0.999860922248685 GO:0061775 cohesin loader activity 1/492 153/18639 0.0065359477124183 0.247608799617408 0.983590518160659 0.999860922248685 GO:0061630 ubiquitin protein ligase activity 4/492 353/18639 0.0113314447592068 0.429282111517999 0.984756480345609 0.999860922248685 GO:0140658 ATP-dependent chromatin remodeler activity 1/492 158/18639 0.00632911392405063 0.239773078110528 0.985661217400596 0.999860922248685 GO:0003689 DNA clamp loader activity 1/492 160/18639 0.00625 0.236775914634146 0.986414527524202 0.999860922248685 GO:0106310 protein serine kinase activity 4/492 361/18639 0.0110803324099723 0.419768934531451 0.986971287641317 0.999860922248685 GO:0140713 histone chaperone activity 1/492 164/18639 0.00609756097560976 0.231000892325996 0.987804714663608 0.999860922248685 GO:0061659 ubiquitin-like protein ligase activity 4/492 372/18639 0.010752688172043 0.4073564122738 0.989522202210344 0.999860922248685 GO:0042393 histone binding 2/492 247/18639 0.00809716599190283 0.306754221388368 0.989942061482292 0.999860922248685 GO:0140597 protein carrier chaperone 1/492 188/18639 0.00531914893617021 0.201511416709912 0.993622080389605 0.999860922248685 GO:0140097 catalytic activity, acting on DNA 3/492 336/18639 0.00892857142857143 0.338251306620209 0.993893593516929 0.999860922248685 GO:0016758 hexosyltransferase activity 1/492 197/18639 0.0050761421319797 0.192305311377987 0.994999470495358 0.999860922248685 GO:0008094 ATP-dependent activity, acting on DNA 1/492 210/18639 0.00476190476190476 0.180400696864112 0.996481972076706 0.999860922248685 GO:0016755 aminoacyltransferase activity 5/492 496/18639 0.0100806451612903 0.381896636506688 0.997075405786096 0.999860922248685 GO:0005525 GTP binding 3/492 378/18639 0.00793650793650794 0.300667828106852 0.997588935034957 0.999860922248685 GO:0004842 ubiquitin-protein transferase activity 4/492 449/18639 0.0089086859688196 0.337497962952903 0.997848200249035 0.999860922248685 GO:0140098 catalytic activity, acting on RNA 3/492 387/18639 0.00775193798449612 0.2936755530346 0.998030382020092 0.999860922248685 GO:0019787 ubiquitin-like protein transferase activity 4/492 479/18639 0.00835073068893528 0.316360303477774 0.998865675173062 0.999860922248685 GO:0045182 translation regulator activity 2/492 356/18639 0.00561797752808989 0.21283228281721 0.999277495532665 0.999860922248685 GO:0030371 translation repressor activity 1/492 329/18639 0.00303951367781155 0.115149380977092 0.999860922248685 0.999860922248685