category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	101/1080	238/9376	3.68415810768752	F13A1/C1QA/RPL27A/RPL23/RPS11/FCGR2A/C1QC/CYBB/RPS23/C1QB/AGTR1/RPL23A/RPS14/RPL13A/RPLP1/UBA52/RPS18/RPS12/RPL15/RPS20/RPLP2/RPL28/RPL26/RPS24/RPS15/RPS7/RPL27/RPL14/RPS27A/RPL38/RPL39/RPL35/RPS2/RPL30/RPL21/RPL18/RPL10/RPL19/RPL32/RPS4X/CFD/RPS19/RPL24/RPS16/RPL13/RPL11/FAU/RPL9/CXCL8/RPS25/RPL37/RPS28/RPS3A/RPS6/RPS15A/RPS13/RPL7/RPL29/RPL34/RPL36/RPL10A/RPL22/RPL31/RPL7A/IL6ST/RPL36A/RPL41/SYK/RPL17/RPL18A/RPL37A/RPS10/RPS17/RPS3/RPLP0/C3AR1/RPL8/RPS5/RPS9/RPL5/RPS21/NRP1/RPL35A/RPS29/RPL6/RPSA/RPL36AL/RPL4/TLR7/C2/NLRP3/MMP1/TLR2/CASP1/PRKCB/TNF/TLR4/OAS3/ACE/TLR8/RPS27L	15.1333173643053
Genetic Information Processing	Translation	hsa03010	Ribosome	82/1080	222/9376	3.20667334000667	RPL27A/RPL23/RPS11/RPS23/RPL23A/RPS14/RPL13A/RPLP1/UBA52/RPS18/RPS12/RPL15/RPS20/RPLP2/RPL28/RPL26/RPS24/RPS15/RPS7/RPL27/RPL14/RPS27A/RPL38/RPL39/RPL35/RPS2/RPL30/RPL21/RPL18/RPL10/RPL19/RPL32/RPS4X/RPS19/RPL24/RPS16/RPL13/RPL11/FAU/RPL9/RPS25/RPL37/RPS28/RPS3A/RPS6/RPS15A/RPS13/RPL7/RPL29/RPL34/RPL36/RPL10A/RPL22/RPL31/RPL7A/RPL36A/RPL41/RPL17/RPL18A/RPL37A/RPS10/RPS17/RPS3/RPLP0/RPL8/RACK1/RPS5/RPS9/RPL5/RPS21/RPL35A/RPS29/RPL6/RPSA/RPL36AL/RPL4/MRPS6/MRPL17/MRPS28/MRPL51/MRPL52/RPS27L	12.0052781185946
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	60/1080	138/9376	3.77455716586151	COX4I2/MT-CO2/MT-CYB/MT-ATP6/MT-ND1/ATP5F1E/ATP5MG/UQCRB/MT-CO3/MT-CO1/COX6C/NDUFA4L2/MT-ND2/MT-ND5/UQCR10/COX4I1/ATP6V1G1/NDUFC2/ATP5MF/COX8A/COX5B/ATP5MC2/UQCR11/NDUFA1/NDUFA13/ATP6V0C/ATP5PF/NDUFA4/COX7C/ATP5MC3/MT-ND3/COX7B/ATP5F1A/NDUFB11/COX6B1/NDUFB3/ATP6V0B/COX7A2/NDUFA2/NDUFA11/NDUFV2/ATP6V1F/NDUFB7/COX6A1/UQCRQ/NDUFS5/NDUFS6/MT-ND6/ATP5ME/ATP5PD/UQCRH/ATP5PB/NDUFA12/NDUFAB1/NDUFB10/ATP5F1D/ATP6V0E1/COX17/ATP5F1C/NDUFB2	11.8469726480205
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	73/1080	205/9376	3.09145438121048	CD36/COX4I2/CYBB/MT-CO2/CYBA/AGTR1/PLCB1/MT-CYB/MT-ATP6/SLC2A1/COL3A1/MT-ND1/ATP5F1E/UQCRB/MT-CO3/MT-CO1/NCF4/COX6C/NDUFA4L2/MT-ND2/MT-ND5/UQCR10/COX4I1/NDUFC2/COX8A/COX5B/ATP5MC2/UQCR11/NDUFA1/NDUFA13/ATP5PF/NDUFA4/COX7C/ATP5MC3/MT-ND3/PPP1CA/COX7B/TBC1D4/ATP5F1A/NDUFB11/COL1A1/COX6B1/RAC1/NCF2/NDUFB3/COX7A2/NDUFA2/PRKCB/MMP2/NDUFA11/NDUFV2/RAC2/CTSD/NDUFB7/SLC25A5/COX6A1/UQCRQ/NDUFS5/SLC25A6/NDUFS6/MT-ND6/ATP5PD/UQCRH/ATP5PB/PLCB2/NDUFA12/PARP1/ACE/NDUFAB1/NDUFB10/ATP5F1D/ATP5F1C/NDUFB2	10.9239605791398
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	79/1080	268/9376	2.55909342177999	COX4I2/MT-CO2/MT-CYB/ITPR2/UBA52/MT-ATP6/RPS27A/MT-ND1/UBB/ATP5F1E/GNAI2/UQCRB/MT-CO3/MT-CO1/COX6C/TUBA1B/NDUFA4L2/MT-ND2/MT-ND5/UQCR10/GNAS/COX4I1/NDUFC2/CALM1/COX8A/COX5B/ATP5MC2/UQCR11/NDUFA1/NDUFA13/ATP5PF/NDUFA4/COX7C/ATP5MC3/MT-ND3/MAPT/COX7B/CALM2/ATP5F1A/CALM3/PSMA1/NDUFB11/COX6B1/NDUFB3/COX7A2/NDUFA2/PSMA4/NDUFA11/NDUFV2/TUBB2B/NDUFB7/SLC25A5/COX6A1/UQCRQ/PSMB1/SNCA/NDUFS5/TUBB/SLC25A6/NDUFS6/PSMA7/TXN2/MT-ND6/ATP5PD/UQCRH/PSMA2/ATP5PB/HSPA5/NDUFA12/NDUFAB1/NDUFB10/ATP5F1D/PARK7/CALML4/GPR37/SOD1/ATP5F1C/NDUFB2/SLC11A2	9.3431037062512
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	80/1080	275/9376	2.52552188552189	C1QA/COX4I2/C1QC/CYBB/MT-CO2/CYBA/C1QB/MT-CYB/ITPR2/MT-ATP6/MT-ND1/ATP5F1E/UQCRB/MT-CO3/MT-CO1/NCF4/COX6C/TUBA1B/NDUFA4L2/MT-ND2/MT-ND5/UQCR10/COX4I1/NDUFC2/COX8A/COX5B/ATP5MC2/UQCR11/NDUFA1/NDUFA13/ATP5PF/NDUFA4/COX7C/ATP5MC3/MT-ND3/COX7B/ATP5F1A/PSMA1/NDUFB11/RYR1/COX6B1/RAC1/NCF2/NDUFB3/COX7A2/NDUFA2/PSMA4/NDUFA11/NDUFV2/RAC2/TUBB2B/NDUFB7/SLC25A5/COX6A1/UQCRQ/PSMB1/NDUFS5/TUBB/GRIN2C/SLC25A6/NDUFS6/TNF/PSMA7/MT-ND6/ATP5PD/UQCRH/PSMA2/CACNA1D/EGR1/ATP5PB/HSPA5/NDUFA12/NDUFAB1/NDUFB10/ATP5F1D/CREB3L1/SOD1/NCAM2/ATP5F1C/NDUFB2	9.26410303262743
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	68/1080	235/9376	2.51208825847124	COX4I2/MT-CO2/MT-CYB/MT-ATP6/MT-ND1/ATP5F1E/ATP5MG/UQCRB/RPS6/MT-CO3/MT-CO1/COX6C/NDUFA4L2/ACTB/MT-ND2/MT-ND5/UQCR10/GNAS/COX4I1/NDUFC2/ATP5MF/COX8A/COX5B/ATP5MC2/UQCR11/NDUFA1/NDUFA13/ATP5PF/NDUFA4/COX7C/ATP5MC3/MT-ND3/COX7B/SOS1/ATP5F1A/COX16/ADCY4/NDUFB11/COX6B1/NDUFB3/COX7A2/NDUFA2/NDUFA11/NDUFV2/NRAS/NDUFB7/COX6A1/UQCRQ/NDUFS5/NDUFS6/MT-ND6/ATP5ME/ATP5PD/UQCRH/PPARG/ATP5PB/NDUFA12/GRB2/NDUFAB1/NPR1/NDUFB10/ATP5F1D/CREB3L1/RPS6KA1/COX17/ATP5F1C/NDUFAF3/NDUFB2	8.46988204051635
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	65/1080	227/9376	2.48588676782509	HGF/COX4I2/MT-CO2/CYBA/MT-CYB/MT-ATP6/MT-ND1/ATP5F1E/MGST2/UQCRB/MT-CO3/MT-CO1/COX6C/NDUFA4L2/MT-ND2/MT-ND5/UQCR10/COX4I1/NDUFC2/COX8A/COX5B/ATP5MC2/UQCR11/NDUFA1/NDUFA13/ATP5PF/NDUFA4/COX7C/ATP5MC3/MT-ND3/COX7B/SOS1/ATP5F1A/NDUFB11/COX6B1/RAC1/NCF2/NDUFB3/COX7A2/NDUFA2/NDUFA11/NDUFV2/NRAS/NDUFB7/SLC25A5/COX6A1/UQCRQ/NDUFS5/SLC25A6/NDUFS6/MT-ND6/ATP5PD/UQCRH/ATP5PB/NDUFA12/SLC26A2/CBR1/GRB2/NDUFAB1/NDUFB10/ATP5F1D/AHR/SOD1/ATP5F1C/NDUFB2	8.17664182929843
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	77/1080	308/9376	2.17037037037037	COX4I2/MT-CO2/PLCB1/MT-CYB/MT-ATP6/MT-ND1/ATP5F1E/UQCRB/MT-CO3/MT-CO1/COX6C/TUBA1B/NDUFA4L2/DNAH8/MT-ND2/MT-ND5/UQCR10/COX4I1/NDUFC2/CLTA/COX8A/COX5B/ATP5MC2/UQCR11/CLTC/NDUFA1/NDUFA13/ATP5PF/NDUFA4/COX7C/GPX7/AP2S1/ATP5MC3/MT-ND3/COX7B/ATP5F1A/PSMA1/NDUFB11/COX6B1/NDUFB3/COX7A2/NDUFA2/PSMA4/NDUFA11/HDAC2/NDUFV2/POLR2K/TUBB2B/NDUFB7/SLC25A5/COX6A1/UQCRQ/PSMB1/NDUFS5/TUBB/SLC25A6/NDUFS6/PSMA7/SLC1A3/MT-ND6/ATP5PD/UQCRH/PSMA2/GRIA4/DCTN6/PPARG/ATP5PB/PLCB2/NDUFA12/NDUFAB1/NDUFB10/ATP5F1D/CREB3L1/SOD1/ATP5F1C/NDUFB2/POLR2L	7.53539573884834
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	90/1080	388/9376	2.01374570446735	WNT2/COX4I2/CYBB/MT-CO2/PLCB1/MT-CYB/ITPR2/MT-ATP6/MT-ND1/ATP5F1E/UQCRB/MT-CO3/MT-CO1/COX6C/TUBA1B/NDUFA4L2/MT-ND2/MT-ND5/LRP6/UQCR10/COX4I1/NDUFC2/CTNNB1/CALM1/COX8A/WNT3A/COX5B/ATP5MC2/UQCR11/NDUFA1/NDUFA13/ATP5PF/NDUFA4/FZD1/COX7C/ATP5MC3/MT-ND3/MAPT/COX7B/CALM2/ATP5F1A/CHRM3/FZD2/CALM3/PSMA1/APH1A/NDUFB11/COX6B1/AXIN2/NDUFB3/COX7A2/NDUFA2/MME/PSMA4/NDUFA11/NDUFV2/NRAS/TUBB2B/NDUFB7/SLC25A5/COX6A1/UQCRQ/PSMB1/SNCA/FZD6/NDUFS5/TUBB/GRIN2C/SLC25A6/NDUFS6/TNF/PSMA7/MT-ND6/WNT2B/ATP5PD/UQCRH/PSMA2/CACNA1D/ATP5PB/PLCB2/NDUFA12/ADAM10/NDUFAB1/NDUFB10/LRP1/ATP5F1D/CALML4/ATP5F1C/NDUFB2/SLC11A2	7.35828326026021
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	101/1080	480/9376	1.82672839506173	WNT2/COX4I2/CYBB/MT-CO2/PLCB1/MT-CYB/ITPR2/UBA52/MT-ATP6/RPS27A/MT-ND1/UBB/ATP5F1E/UQCRB/MT-CO3/MT-CO1/COX6C/TUBA1B/NDUFA4L2/DNAH8/MT-ND2/MT-ND5/LRP6/UQCR10/COX4I1/NDUFC2/CTNNB1/CALM1/COX8A/WNT3A/COX5B/ATP5MC2/UQCR11/NDUFA1/NDUFA13/ATP5PF/NDUFA4/FZD1/COX7C/GPX7/ATP5MC3/MT-ND3/MAPT/COX7B/CALM2/ATP5F1A/CHRM3/FZD2/CALM3/PSMA1/NDUFB11/RYR1/COX6B1/RAC1/AXIN2/NDUFB3/TANK/COX7A2/NDUFA2/PRKCB/TNFRSF1B/PSMA4/NDUFA11/NDUFV2/NRAS/TUBB2B/NDUFB7/SLC25A5/COX6A1/UQCRQ/PSMB1/SNCA/FZD6/NDUFS5/TUBB/GRIN2C/SLC25A6/NDUFS6/TNF/PSMA7/MT-ND6/WNT2B/ATP5PD/UQCRH/PSMA2/CACNA1D/GRIA4/DCTN6/ATP5PB/HSPA5/PLCB2/NDUFA12/NDUFAB1/NDUFB10/ATP5F1D/PARK7/CALML4/GPR37/SOD1/ATP5F1C/NDUFB2	6.70886773883949
NA	NA	hsa04517	IgSF CAM signaling	71/1080	299/9376	2.06148891366283	MTSS1/PTPRD/CADM1/CADM3/ROBO2/KDR/ARPC3/JAM2/TUBA1B/EZR/LYN/MYL12A/ARPC1B/ACTB/LCP2/SLIT2/CD86/CD28/ICAM2/MYL12B/INPP5D/CTNNB1/NRP1/ITGB2/VAV3/CD84/CD209/ITGA4/VAV1/EPB41L3/DOK2/IL1RAPL1/CDC42/KIRREL3/ROBO4/ITGAM/DYNLL1/PMP22/RAC1/PTPN6/ARPC5/PRKCB/ARF6/ARPC2/TUBB2B/NCK2/GRIP2/F11R/MYH10/SPTBN1/ACTR2/NRCAM/CADM2/TUBB/CLEC4M/SLAMF1/MYL6B/CASKIN2/ICAM1/CABLES1/RDX/ANK3/JAM3/PAK4/GRB2/TJP1/ROBO1/ESAM/NCAM2/RAPGEF2/ITGAL	6.73043343522005
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	45/1080	157/9376	2.48832271762208	COX4I2/MT-CO2/MT-CYB/CXCL8/UQCRB/MT-CO3/MT-CO1/COX6C/NDUFA4L2/UQCR10/COX4I1/NDUFC2/COX8A/COX5B/UQCR11/NDUFA1/NDUFA13/NDUFA4/COX7C/COX7B/CDC42/NDUFB11/COX6B1/RAC1/NDUFB3/COX7A2/NDUFA2/NDUFA11/NDUFV2/MAP3K11/ADIPOR1/NDUFB7/COX6A1/UQCRQ/NDUFS5/NDUFS6/TNF/CEBPA/UQCRH/NR1H3/PPARG/NDUFA12/NDUFAB1/NDUFB10/NDUFB2	6.78528624842875
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	44/1080	155/9376	2.46442054958184	CD14/CD36/FCGR2A/CYBB/CYBA/FCGR3A/FCGR2B/MRC1/MSR1/COLEC12/NCF4/SCARB1/TUBA1B/ACTB/CALR/FCGR1A/CLEC7A/ATP6V1G1/CTSS/HLA-C/ITGB2/CORO1A/ATP6V0C/CD209/CTSL/ITGAM/STX7/ITGA2/RAC1/TLR2/NCF2/ATP6V0B/TUBB2B/ATP6V1F/SEC61G/TUBB/HLA-E/CLEC4M/TLR6/SEC61B/CANX/TLR4/OLR1/ATP6V0E1	6.63293584660686
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	80/1080	368/9376	1.88727858293076	COX4I2/MT-CO2/MT-CYB/MT-ATP6/MT-ND1/ATP5F1E/UQCRB/MT-CO3/MT-CO1/COX6C/TUBA1B/NDUFA4L2/ACTB/DNAH8/MT-ND2/MT-ND5/UQCR10/COX4I1/NDUFC2/HNRNPA1/PFN1/COX8A/COX5B/ATP5MC2/UQCR11/NDUFA1/NDUFA13/ATP5PF/NDUFA4/COX7C/GPX7/ATP5MC3/MT-ND3/COX7B/ATP5F1A/HNRNPA2B1/PSMA1/NDUFB11/COX6B1/RAC1/CASP1/HNRNPA3/NDUFB3/TANK/COX7A2/NDUFA2/TNFRSF1B/PSMA4/NDUFA11/NDUFV2/TUBB2B/SRSF3/NDUFB7/COX6A1/UQCRQ/PSMB1/NDUFS5/TUBB/GRIN2C/NDUFS6/TNF/PSMA7/MT-ND6/ATP5PD/UQCRH/PSMA2/DCTN6/ATP5PB/HSPA5/ALYREF/NDUFA12/NDUFAB1/NDUFB10/ATP5F1D/NUP50/SOD1/ATP5F1C/TPR/NDUFB2/NRG2	6.26517005501908
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	21/1080	50/9376	3.64622222222222	HBB/HGF/HBA2/CD36/HBA1/PECAM1/CR1/CXCL8/ITGB2/CR1L/TLR2/VCAM1/SDC1/GYPC/TNF/KLRB1/ICAM1/TLR4/GYPB/LRP1/ITGAL	6.76903489702289
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	35/1080	116/9376	2.61941251596424	CYBB/CYBA/PECAM1/CDH5/GNAI2/NCF4/JAM2/EZR/MYL12A/ACTB/MYL12B/CTNNB1/ITGB2/VAV3/ITGA4/VAV1/CDC42/ITGAM/TXK/RAC1/NCF2/PRKCB/MMP2/VCAM1/RAC2/CLDN11/F11R/OCLN/CXCR4/ICAM1/JAM3/RAPGEF3/ESAM/SIPA1/ITGAL	6.33204710547094
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	50/1080	212/9376	2.04751921733054	HGF/PLCB1/GNAI2/CSF1R/FYB1/KDR/ID1/ACTB/P2RY1/LCP2/IGF1/DOCK4/SIPA1L2/GNAS/RAPGEF5/TEK/CTNNB1/PFN1/CALM1/ITGB2/VAV3/RASGRP3/VAV1/FGFR3/EFNA5/CALM2/CDC42/ITGAM/ADCY4/FGFR2/CALM3/RAC1/APBB1IP/PRKCB/LPAR5/RAC2/NRAS/MAGI3/FPR1/PDGFC/KITLG/PLCB2/KIT/EFNA1/RAPGEF3/CALML4/ARAP3/RAPGEF2/SIPA1/ITGAL	5.56609396330849
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	39/1080	149/9376	2.27233407904549	GNGT1/PLCB1/ITPR2/GNG2/GNG11/MT-ND1/GNAI2/NDUFA4L2/MT-ND2/MT-ND5/GNG10/NDUFC2/GNG5/NDUFA1/NDUFA13/NDUFA4/MT-ND3/ADCY4/NDUFB11/NDUFB3/GNB2/KCNJ5/NDUFA2/PRKCB/NDUFA11/NDUFV2/NDUFB7/NDUFS5/NDUFS6/GABRA3/MT-ND6/CACNA1D/GRIA4/PLCB2/NDUFA12/NDUFAB1/GNB4/NDUFB10/NDUFB2	5.64842254669078
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	27/1080	87/9376	2.69425287356322	COX4I2/MT-CO2/MT-CYB/UQCRB/ATP1B1/MT-CO3/MT-CO1/COX6C/UQCR10/COX4I1/COX8A/COX5B/UQCR11/COX7C/TPM3/SLC8A1/COX7B/COX6B1/CACNB4/COX7A2/COX6A1/UQCRQ/ATP1B3/MYL4/UQCRH/TNNT2/CACNA1D	5.72817819855832
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	29/1080	98/9376	2.56900982615268	MARCKS/FCGR2A/FCGR3A/FCGR2B/PTPRC/ARPC3/LYN/SYK/ARPC1B/MYO10/FCGR1A/INPP5D/VAV3/HCK/VAV1/PLPP3/CFL1/BIN1/CDC42/WAS/SCIN/RAC1/ARPC5/PRKCB/ARF6/ARPC2/RAC2/ACTR2/MARCKSL1	5.63345281962013
Organismal Systems	Endocrine system	hsa04924	Renin secretion	22/1080	69/9376	2.76800858829844	AGTR1/PLCB1/ITPR2/ADRB1/GNAI2/PDE3B/GNAS/GUCY1A2/CALM1/CALM2/CALM3/ORAI1/PTGER4/GUCY1A1/GUCY1B1/CACNA1D/PLCB2/ACE/NPR1/CALML4/ADRB2/ADORA1	5.31823107077568
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	45/1080	204/9376	1.91503267973856	HGF/WNT2/LUM/DCN/GPC3/ITPR2/CCND1/IGF2/KDR/HPSE2/RPS6/EZR/ACTB/IGF1/VTN/CTNNB1/WNT3A/HCLS1/VAV3/FZD1/VAV1/TWIST1/PPP1CA/CD63/CTSL/SOS1/CDC42/FZD2/PDCD4/COL1A1/ITGA2/RAC1/TLR2/PTPN6/PRKCB/MMP2/SDC1/NRAS/FZD6/TNF/WNT2B/TLR4/RDX/ANK3/GRB2	4.76741336664197
Organismal Systems	Immune system	hsa04611	Platelet activation	31/1080	126/9376	2.13592004703116	FCGR2A/FCER1G/VAMP8/PLCB1/ITPR2/COL3A1/GNAI2/LYN/SYK/MYL12A/ACTB/P2RY1/LCP2/GNAS/GUCY1A2/MYL12B/TBXAS1/PPP1CA/ADCY4/COL1A1/ITGA2/APBB1IP/PIK3R5/PIK3CG/ORAI1/FERMT3/GUCY1A1/GUCY1B1/TBXA2R/PLCB2/GNA13	4.63153888494904
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	33/1080	140/9376	2.04634920634921	SPP1/GNGT1/AGTR1/PLCB1/ITPR2/GNG2/GNG11/APLNR/APLN/CCND1/GNAI2/MEF2C/RPS6/PDE3B/GNG10/KLF2/CALM1/GNG5/SLC8A1/CALM2/ADCY4/CALM3/RYR1/GNB2/PIK3R5/PIK3CG/NRAS/MYL4/EGR1/PLCB2/GNB4/CALML4/GNA13	4.50051122464758
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	50/1080	250/9376	1.7362962962963	LGMN/VAMP8/NPC2/CTSC/ASAH1/LAPTM5/CD68/ATP6V1G1/CTSS/CLTA/AP1S2/CLTC/ATP6V0C/FUCA1/AP2S1/CD63/CTSL/CTSZ/AP1B1/MCOLN2/TLR7/SUMF1/CD164/LAMTOR5/NAGA/HYAL2/MANBA/ATP6V0B/DMXL2/ACP2/SLC15A3/LAMTOR1/CTSD/ATP6V1F/LAMTOR4/CTSO/AP3M2/GPR155/PLA2G15/LAPTM4A/HEXA/SLC38A9/HYAL4/BLOC1S1/TLR8/ATP6V0E1/LAMTOR2/PSAP/VPS29/SLC11A2	4.25741055248503
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	25/1080	97/9376	2.23749522718595	GNGT1/PLCB1/GNG2/GNG11/GNAI2/GNG10/GNAS/GUCY1A2/CALM1/GNG5/CALM2/ADCY4/CALM3/RYR1/GNB2/KCNJ5/PRKCB/GUCY1A1/GUCY1B1/GRIN2C/CACNA1D/GRIA4/PLCB2/GNB4/CALML4	4.42020037040397
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	46/1080	227/9376	1.75924294338391	B2M/GNGT1/CCL3/PLCB1/CCL4/ITPR2/GNG2/GNG11/CCL4L2/CCND1/CDK6/CCL3L1/GNAI2/CXCL8/CALR/GNG10/CCR1/GNAS/HLA-C/CTNNB1/CALM1/GNG5/EIF4EBP1/SOS1/CALM2/ADCY4/CALM3/RB1/RAC1/IL10RA/GNB2/PRKCB/RAC2/NRAS/PTGER4/IL10RB/HLA-E/TNF/PDIA3/CXCR4/PLCB2/GRB2/GNB4/CREB3L1/CALML4/GNA13	4.17801527269763
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	21/1080	78/9376	2.33732193732194	C1QA/CD14/C1QC/C1QB/GNAI2/CXCL8/LY96/CALM1/ITGB2/C4BPB/CFL1/PYCARD/CALM2/ITGAM/C2/NLRP3/CALM3/CASP1/TNF/TLR4/CALML4	4.27909219315927
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	39/1080	193/9376	1.75428900402994	CXCL14/GNGT1/CCL3/PLCB1/ELMO1/CCL4/GNG2/GNG11/CCL4L2/CCL3L1/GNAI2/CXCL8/LYN/GNG10/DOCK2/CCR1/PREX1/GNG5/VAV3/HCK/VAV1/SOS1/CDC42/WAS/ADCY4/ARRB2/RAC1/GNB2/PRKCB/PIK3R5/PIK3CG/RAC2/NRAS/CX3CR1/CXCR4/GRK3/PLCB2/GRB2/GNB4	3.82021040607551
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	40/1080	200/9376	1.7362962962963	FCGR2A/TNFSF10/CXCL8/ARPC3/TUBA1B/EZR/ARPC1B/ACTB/MYO10/RPS3/CYTH4/HCLS1/TMBIM6/PYCARD/CDC42/NCKAP1L/NLRP3/RAC1/CASP1/MYO1F/PTPN6/ARPC5/LPAR5/ARF6/ARPC2/ARF1/TUBB2B/NCK2/CLDN11/MYH10/ACTR2/TUBB/TNF/WIPF1/OCLN/TLR4/CYTH1/TJP1/GNA13/NCL	3.79755485197784
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	47/1080	248/9376	1.6452807646356	CD14/ELMO1/S100A10/TNFSF10/PTPRC/CXCL8/ARPC3/LEF1/LY96/TUBA1B/MYL12A/ARPC1B/ACTB/RPS3/MYL12B/CTNNB1/PFN1/CYTH4/PYCARD/CDC42/NCKAP1L/NLRP3/SNX18/DYNLL1/RAC1/TLR2/CASP1/ARPC5/HSP90B1/DYNLRB1/ARF6/ARPC2/PIK3CG/ARF1/TUBB2B/ACTR2/TUBB/TLR6/TNF/TXN2/TLR4/PIK3C2A/DCTN6/CYTH1/SKP1/RIPK3/RHOG	3.71577910520397
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	22/1080	89/9376	2.14598418643362	PLCB1/ITPR2/ADRB1/GJA1/GNAI2/TUBA1B/GNAS/GUCY1A2/SOS1/ADCY4/PRKCB/NRAS/TUBB2B/CDK1/GUCY1A1/GUCY1B1/TUBB/PDGFC/MAP2K5/PLCB2/GRB2/TJP1	3.91921464777635
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	30/1080	138/9376	1.88727858293076	FCGR2A/ELMO1/FYB1/CXCL8/ARPC3/ARPC1B/ACTB/LCP2/VAV3/ITGA4/VAV1/CD4/PYCARD/CDC42/WAS/PKN2/SKAP2/NLRP3/RAC1/CASP1/ARPC5/ARF6/ARPC2/RAC2/ACTR2/TNF/WIPF1/TLR4/RPS6KA1/RHOG	3.78855596579182
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	34/1080	166/9376	1.77813476126729	AGTR1/PLCB1/ITPR2/ADRB1/GNAI2/GATA4/MEF2C/ATP1B1/PDE3B/GUCY1A2/CALM1/SLC8A1/PPP1CA/CALM2/ADCY4/CALM3/KCNMB4/PIK3R5/PIK3CG/SLC25A5/EDNRB/GUCY1A1/GUCY1B1/ATP2B1/ATP1B3/SLC25A6/CACNA1D/PLCB2/NPR1/CREB3L1/CALML4/ADRB2/GNA13/ADORA1	3.64957413436243
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	41/1080	214/9376	1.66327448944271	B2M/GNGT1/ITPR2/GNG2/GNG11/GNAI2/CALR/GNG10/HLA-C/AP1S2/BST2/CALM1/GNG5/ELOB/CFL1/AP1B1/CD4/CALM2/CALM3/TRIM5/RAC1/TLR2/RBX1/GNB2/PRKCB/TNFRSF1B/RAC2/NRAS/CDK1/RNF7/HLA-E/TNF/ATM/PDIA3/CCNB2/CXCR4/TLR4/PAK4/GNB4/SKP1/CALML4	3.54134453634456
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	30/1080	142/9376	1.83411580594679	CYBA/PECAM1/CDH5/MGST2/KDR/MEF2C/ACTB/KLF2/CTNNB1/SUMO2/CALM1/BMP4/CTSL/GSTP1/CALM2/CALM3/RAC1/NCF2/HSP90B1/MMP2/VCAM1/RAC2/SDC1/SUMO1/TNF/TXN2/ICAM1/ACVR2A/MAP2K5/CALML4	3.61358880588304
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	23/1080	100/9376	1.99674074074074	CD14/CD36/CR1/CD34/CSF1R/FCGR1A/CD24/ITGA4/CR1L/CD4/ITGA6/ITGAM/ITGA2/ANPEP/CSF3R/MME/CD37/CSF2RA/CD33/CD9/TNF/KITLG/KIT	3.61547184795895
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	34/1080	170/9376	1.7362962962963	CCND1/CGNL1/GATA4/ARPC3/JAM2/TUBA1B/EZR/MYL12A/ARPC1B/ACTB/MYL12B/MAP3K1/HCLS1/CDC42/WAS/PCNA/NEDD4L/RAC1/ARPC5/LLGL2/ARPC2/CLDN11/F11R/MYH10/ACTR2/MYL6B/NEDD4/OCLN/CACNA1D/RDX/JAM3/TJP1/EPB41L4B/RAPGEF2	3.4954632104563
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	32/1080	157/9376	1.76947393253126	C1QA/CD36/C1QC/C1QB/ELMO1/PECAM1/SLC2A1/CALR/STAB1/CD24/ATP8A1/S1PR1/RAC1/CASP1/SCARF1/PTPN6/SIRPA/MERTK/DUSP4/ALOX5/PTGER4/CX3CR1/PLA2G15/GAS6/NR1H3/PPARG/ADAM10/ATP11A/HAVCR2/LRP1/CD47/DNMT3A	3.50804353861545
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	23/1080	101/9376	1.97697103043638	WNT2/PLCB1/GNAI2/LEF1/GNAS/CTNNB1/CALM1/WNT3A/FZD1/CALM2/FZD2/ADCY4/CALM3/PRKCB/NRAS/EDNRB/FZD6/WNT2B/KITLG/PLCB2/KIT/CREB3L1/CALML4	3.56162800917096
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	19/1080	78/9376	2.11471984805318	FCGR2A/CYBB/CYBA/FCGR3A/CR1/NCF4/FCGR1A/EEF1A1/ITGB2/ITGA4/CR1L/ITGAM/TLR2/PTPN6/NCF2/PRKCB/TNF/MARCKSL1/TLR4	3.56682176986958
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	32/1080	160/9376	1.7362962962963	PECAM1/PTPRD/CADM1/CDH5/CD34/CADM3/PTPRC/JAM2/CD86/CD28/ICAM2/ITGA9/HLA-C/ITGB2/SIGLEC1/NTNG1/ITGA4/CD4/ITGA6/ITGAM/VCAM1/SDC1/CLDN11/F11R/NRCAM/HLA-E/OCLN/ICAM1/JAM3/ESAM/NCAM2/ITGAL	3.38925713071691
NA	NA	hsa04518	Integrin signaling	31/1080	154/9376	1.74757094757095	SPP1/HGF/LAMA2/LAMC3/CCND1/KDR/ACTB/IGF1/ICAM2/VTN/ITGA9/CTNNB1/CCND2/ITGB2/FREM1/ITGA4/ITGA6/CDC42/ITGAM/COL1A1/ITGA2/RAC1/VCAM1/RAC2/NCK2/FERMT3/COL6A6/ICAM1/PDGFC/PARVB/ITGAL	3.3749190547678
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	22/1080	98/9376	1.94890400604686	AGTR1/PLCB1/ITPR2/ATP1B1/SCARB1/GNAS/CALM1/KCNK3/CALM2/ADCY4/CALM3/NR4A2/KCNJ5/PRKCB/ORAI1/ATP2B1/ATP1B3/CACNA1D/PLCB2/NPR1/CREB3L1/CALML4	3.40699328921433
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	40/1080	216/9376	1.6076817558299	CD14/CD36/CCL3/CYBB/CYBA/PLCB1/CCL3L1/TNFSF10/CXCL8/NCF4/LY96/LYN/CALM1/VAV3/VAV1/POU2F2/HSPA2/PYCARD/CALM2/CDC42/NLRP3/CALM3/MMP1/RAC1/TLR2/CASP1/NCF2/HSP90B1/TANK/VCAM1/NRAS/TLR6/TNF/ICAM1/TLR4/OLR1/PPARG/HSPA5/PLCB2/CALML4	3.26000661190484
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	42/1080	232/9376	1.57164750957854	TMSB4X/IQGAP2/ARPC3/EZR/MYL12A/ARPC1B/ACTB/MYL12B/ITGA9/PFN1/ITGB2/VAV3/ITGA4/VAV1/PPP1CA/CFL1/FGFR3/SOS1/ITGA6/CDC42/NCKAP1L/SCIN/CHRM3/ITGAM/FGFR2/ITGA2/RAC1/ARPC5/LPAR5/ARPC2/RAC2/NRAS/MYH10/CHRM2/ACTR2/CXCR4/PDGFC/RDX/FGD3/PAK4/GNA13/ITGAL	3.18102691550773
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	18/1080	76/9376	2.05614035087719	PLCB1/ITPR2/GNAI2/ATP1B1/EZR/ACTB/GNAS/CALM1/KCNQ1/CALM2/CHRM3/ADCY4/CALM3/PRKCB/HRH2/ATP1B3/PLCB2/CALML4	3.33541672163999
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	11/1080	37/9376	2.58098098098098	HBB/HBA2/HBA1/IDO2/PLCB1/IDO1/PRKCB/VCAM1/TNF/ICAM1/PLCB2	3.47648583380937
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	21/1080	95/9376	1.91906432748538	CCL3/CCL3L1/CXCL8/CD86/CD28/ATP6V1G1/TEK/ITGB2/ATP6V0C/TNFRSF11A/CTSL/TNFSF13B/MMP1/TLR2/ATP6V0B/ATP6V1F/TNF/ICAM1/TLR4/ATP6V0E1/ITGAL	3.24842968332555
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	44/1080	250/9376	1.52794074074074	DAB2/FOLR2/WWP1/ARPC3/SNX2/ARPC1B/RAB11FIP1/HLA-C/CLTA/PSD3/SNX6/CYTH4/CLTC/SH3KBP1/AP2S1/SNX3/FGFR3/CHMP5/BIN1/CDC42/ARAP2/FGFR2/NEDD4L/ARRB2/ARPC5/MVB12B/ARF6/ARPC2/ARF1/ACTR2/HLA-E/WIPF1/NEDD4/CXCR4/GRK3/ARAP1/WASHC4/IQSEC1/CYTH1/CAPZA1/ARAP3/SH3GL3/VPS29/ACAP2	3.05265759453434
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	34/1080	181/9376	1.63077552690812	CD14/FCGR2A/FCER1G/FCGR3A/FCGR2B/CR1/MRC1/SYK/FCGR1A/CLEC7A/CTSS/CALM1/ITGB2/TLR1/LSP1/CORO1A/ATP6V0C/CD209/CR1L/CALM2/ITGAM/CALM3/TLR2/IL10RA/ATP6V0B/CASP10/CTSD/IL10RB/CLEC4M/TLR6/TNF/CD74/TLR4/CALML4	3.09172886004582
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	36/1080	196/9376	1.59455782312925	GNGT1/ITPR2/GNG2/UBA52/GNG11/CCND1/RPS27A/CDK6/UBB/CXCL8/LEF1/LYN/IL6ST/SYK/GNG10/CCR1/CD86/PREX1/HLA-C/CTNNB1/CALM1/GNG5/HCK/CD200R1/CALM2/CALM3/RB1/RAC1/GNB2/PIK3R5/PIK3CG/NRAS/HLA-E/ICAM1/GNB4/CALML4	3.03503663176979
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	14/1080	56/9376	2.17037037037037	CD14/CR1/CXCL8/EEF1A1/ITGB2/CR1L/EEF1G/PYCARD/ITGAM/TLR2/CASP1/ARF1/TNF/TLR4	3.16936691516575
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/1080	68/9376	2.04270152505447	CD14/CCND1/CSF1R/DUSP6/LEF1/FCGR1A/SPI1/EIF4EBP1/SOS1/ITGAM/NRAS/CEBPA/BCL2A1/KIT/GRB2/CCNA2	3.11350395721144
Organismal Systems	Digestive system	hsa04970	Salivary secretion	20/1080	93/9376	1.86698526483473	PLCB1/ITPR2/ADRB1/ATP1B1/GNAS/GUCY1A2/LYZ/CALM1/CALM2/CHRM3/ADCY4/CALM3/PRKCB/GUCY1A1/GUCY1B1/ATP2B1/ATP1B3/PLCB2/CALML4/ADRB2	3.03160182357356
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	29/1080	154/9376	1.63482443482443	PLCB1/ITPR2/CCND1/GNAI2/MEF2C/ACTB/GNAS/GUCY1A2/CALM1/PPP1CA/TRPM2/CALM2/ADCY4/CALM3/RYR1/CACNB4/KCNJ5/PRKCB/PIK3R5/PIK3CG/NRAS/GUCY1A1/GUCY1B1/MYL6B/CACNA1D/MAP2K5/PLCB2/NPR1/CALML4	2.86592341299868
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	29/1080	157/9376	1.60358575135645	AREG/WNT2/BMP5/CCND1/ID1/LEF1/ACTB/ID2/CTNNB1/CCND2/BMP4/BMP6/ITGB2/WNT3A/FZD1/YWHAB/PPP1CA/FZD2/WWC1/AXIN2/BMP7/LLGL2/YWHAE/BIRC5/FZD6/WNT2B/RASSF6/AJUBA/MOB1A	2.75175675942777
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	9/1080	31/9376	2.52043010752688	SRP14/SPCS1/SPCS2/SPCS3/SEC61G/SEC61B/SRP9/HSPA5/SEC11A	3.05929107146281
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	32/1080	178/9376	1.56071577195173	WNT2/PLCB1/CCND1/RSPO2/LEF1/RSPO3/LRP6/CTNNB1/SERPINF1/CCND2/BAMBI/WNT3A/FZD1/CTNNBIP1/GPC4/FZD2/VANGL2/RAC1/FRZB/AXIN2/RBX1/PRKCB/SOX17/SFRP1/RAC2/PRICKLE1/LGR5/FZD6/WNT2B/PLCB2/SKP1/NOTUM	2.72501699395618
Organismal Systems	Nervous system	hsa04730	Long-term depression	14/1080	60/9376	2.02567901234568	PLCB1/ITPR2/GNAI2/LYN/IGF1/GNAS/GUCY1A2/RYR1/PRKCB/NRAS/GUCY1A1/GUCY1B1/PLCB2/GNA13	2.87564650555864
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	5/1080	12/9376	3.61728395061728	FCGR2B/CD209/CLEC4M/SLAMF1/NCAM2	3.27321028258031
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	57/1080	362/9376	1.36697360343769	SPP1/AREG/HGF/LAMA2/GNGT1/LAMC3/GNG2/GNG11/CCND1/CDK6/CSH1/LPAR6/IGF2/CSF1R/KDR/RPS6/SYK/PRLR/IGF1/GNG10/VTN/ITGA9/TEK/PIK3AP1/CCND2/GNG5/EIF4EBP1/ITGA4/YWHAB/FGFR3/SOS1/EFNA5/ITGA6/FGFR2/PKN2/COL1A1/ITGA2/RAC1/TLR2/CSF3R/HSP90B1/GNB2/LPAR5/PIK3R5/PIK3CG/NRAS/YWHAE/CHRM2/COL6A6/PDGFC/TLR4/KITLG/KIT/GRB2/EFNA1/GNB4/CREB3L1	2.56917376772232
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	20/1080	99/9376	1.75383464272353	C1QA/FCGR2A/C1QC/C1QB/FCGR3A/FCGR2B/CFD/KRT18/FCGR1A/C3AR1/ITGB2/KRT23/PTAFR/ITGAM/C2/KRT19/FPR1/ICAM1/CFI/ITGAL	2.72052709104375
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	40/1080	238/9376	1.45907251789605	HGF/GNGT1/GNG2/GNG11/IGF2/CSF1R/KDR/IGF1/GNG10/RALGAPA2/PLA2G2A/RAPGEF5/TEK/CALM1/GNG5/RASGRP3/RGL1/FGFR3/SOS1/EFNA5/RASGRF2/CALM2/CDC42/FGFR2/CALM3/PLAAT3/RAC1/GNB2/PRKCB/ARF6/RAC2/NRAS/PDGFC/KITLG/KIT/PAK4/GRB2/EFNA1/GNB4/CALML4	2.58825666291949
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	19/1080	93/9376	1.77363600159299	PLCB1/ITPR2/GNAS/MAP3K1/CALM1/CGA/SOS1/CALM2/CDC42/ADCY4/CALM3/PRKCB/MMP2/NRAS/CACNA1D/EGR1/PLCB2/GRB2/CALML4	2.70518589916123
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	28/1080	154/9376	1.57845117845118	AGTR1/PLCB1/ADRB1/GNAI2/ATP1B1/GNAS/CALM1/KCNQ1/TPM3/SLC8A1/PPP1CA/CALM2/CREM/ADCY4/CALM3/CACNB4/PIK3R5/PIK3CG/ATP2B1/ATP1B3/MYL4/TNNT2/CACNA1D/PLCB2/RAPGEF3/CREB3L1/CALML4/ADRB2	2.61142559211412
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	11/1080	44/9376	2.17037037037037	MAN1A1/MGAT4A/RPN2/TUSC3/MGAT4C/TMEM258/HEXA/KRTCAP2/OSTC/MGAT4B/DDOST	2.80753666021023
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	13/1080	56/9376	2.01534391534392	MAN1A1/ST6GAL1/MGAT4A/ST6GAL2/RPN2/TUSC3/MGAT4C/TMEM258/KRTCAP2/OSTC/MGAT4B/DDOST/ALG10B	2.74955475144804
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	18/1080	88/9376	1.77575757575758	F13A1/C1QA/C1QC/C1QB/CR1/CFD/F5/VSIG4/C3AR1/VTN/ITGB2/CR1L/C4BPB/ITGAM/A2M/C2/F3/CFI	2.63796726736596
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	15/1080	69/9376	1.88727858293076	FCER1G/LYN/SYK/LCP2/INPP5D/ALOX5AP/VAV3/VAV1/SOS1/RAC1/RAC2/NRAS/ALOX5/TNF/GRB2	2.66896470945176
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/1080	51/9376	2.04270152505447	ACTB/GNAS/ATP6V1G1/KCNQ1/ATP6V0C/ATP6V0B/ARF1/ATP6V1F/SEC61G/SEC61B/TJP1/ATP6V0E1	2.69391458015168
Human Diseases	Substance dependence	hsa05032	Morphine addiction	18/1080	91/9376	1.71721611721612	GNGT1/GNG2/GNG11/GNAI2/PDE3B/GNG10/GNAS/GNG5/PDE4B/ADCY4/ARRB2/GNB2/KCNJ5/PRKCB/GABRA3/GRK3/GNB4/ADORA1	2.48052110676665
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	12/1080	53/9376	1.96561844863732	PLCB1/KL/ATP1B1/GNAS/CLTA/CLTC/AP2S1/SLC8A1/PRKCB/ATP2B1/ATP1B3/PLCB2	2.54348272045833
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	24/1080	133/9376	1.56658312447786	TYROBP/FCER1G/HCST/FCGR3A/TNFSF10/SYK/LCP2/ICAM2/HLA-C/ITGB2/VAV3/VAV1/SOS1/RAC1/PTPN6/PRKCB/RAC2/NRAS/HLA-E/TNF/ICAM1/GRB2/SH3BP2/ITGAL	2.37435757256948
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	24/1080	133/9376	1.56658312447786	GNGT1/PLCB1/ITPR2/GNG2/GNG11/GNAI2/GNG10/GNAS/CALM1/GNG5/PPP1CA/CALM2/CALM3/ARRB2/GNB2/KCNJ5/PRKCB/CACNA1D/GRIA4/COMT/PLCB2/GNB4/CREB3L1/CALML4	2.37435757256948
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	24/1080	134/9376	1.55489220563847	AGTR1/PLCB1/ITPR2/RAMP2/PLA2G2A/GNAS/GUCY1A2/CALM1/PPP1CA/PRKCH/CALM2/ADCY4/CALM3/KCNMB4/PRKCB/MYH10/GUCY1A1/GUCY1B1/MYL6B/CACNA1D/PLCB2/NPR1/CALML4/GNA13	2.33421677505358
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	26/1080	149/9376	1.51488938603033	FCER1G/AGTR1/PLCB1/LPAR6/CXCL8/SYK/GNAS/CYTH4/PLPP3/SOS1/ADCY4/LPAR5/PIK3R5/ARF6/PIK3CG/ARF1/NRAS/PDGFC/PTGFR/KITLG/PLCB2/KIT/CYTH1/GRB2/RAPGEF3/GNA13	2.28580910077273
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	21/1080	115/9376	1.58531400966184	GNGT1/PLCB1/ITPR2/GNG2/GNG11/GNAI2/GNG10/GNG5/KCNQ1/CHRM3/ADCY4/GNB2/PRKCB/PIK3R5/PIK3CG/NRAS/CHRM2/CACNA1D/PLCB2/GNB4/CREB3L1	2.27862071651479
NA	NA	hsa04519	Cadherin signaling	60/1080	404/9376	1.28932893289329	WNT2/CDH5/GJA1/PCDH18/KDR/KRT18/ARPC3/LEF1/PCDH12/ARPC1B/PCDH10/ACTB/LRP6/CTNNB1/KRT8/WNT3A/CDH19/VAV3/DSP/FMN1/FZD1/PCDH17/CDH11/VAV1/KRT23/YWHAB/PPP1CA/CDC42/NCKAP1L/FZD2/PCDH11X/DSC2/APH1A/WWC1/VANGL2/RAC1/MYO1F/AXIN2/ARPC5/MYO7A/ARPC2/TMC6/KRT7/RAC2/KRT1/PRICKLE1/NRAS/YWHAE/KRT19/TMC8/ACTR2/TAOK2/CDH8/FZD6/GABRA3/WNT2B/AJUBA/MOB1A/ADAM10/TJP1	2.14487041868256
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	33/1080	201/9376	1.4253178551686	CD14/MAF/CSF1R/DUSP6/CXCL8/FLI1/MEF2C/PROM1/ID2/IGF1/FCGR1A/CD86/BMP2K/CCND2/SPI1/LYL1/HHEX/LMO2/SPINT1/ITGAM/ERG/ETV5/HDAC2/TSPAN7/ATM/CEBPA/BCL2A1/PPARG/HPGD/ETV1/KLF3/RUNX2/CCNA2	2.19923557266858
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	15/1080	75/9376	1.7362962962963	PLCB1/ITPR2/ATP1B1/GNAS/CGA/GPX7/ADCY4/HSP90B1/PRKCB/LRP2/ATP1B3/CANX/HSPA5/PLCB2/CREB3L1	2.30983825452203
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	21/1080	116/9376	1.57164750957854	GNGT1/PLCB1/ITPR2/GNG2/GNG11/GNAI2/GNG10/GNAS/GNG5/ADCY4/SHANK3/GNB2/PRKCB/GRIN2C/SLC1A3/CACNA1D/GRIA4/GRK3/PLCB2/GRIK4/GNB4	2.23519265331924
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	23/1080	130/9376	1.53595441595442	GNGT1/PLCB1/GNG2/GNG11/COL3A1/GNAI2/GNG10/GNAS/GNG5/SOS1/ADCY4/ARRB2/COL1A1/MMP1/GNB2/MMP2/NRAS/EDNRB/GNA15/PLCB2/GRB2/GNB4/CREB3L1	2.22016744138768
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	32/1080	195/9376	1.42465337132004	FCGR2A/CYBB/CYBA/FCGR3A/PLCB1/CR1/NCF4/SYK/ACTB/FCGR1A/CLEC7A/ITGB2/CLCN5/CR1L/TLR7/HMGB1/ITGAM/RAC1/TLR2/CASP1/NCF2/PRKCB/HDAC2/RAC2/SLC25A5/FPR1/SIGLEC9/SLC25A6/TLR4/PLCB2/TLR8/ITGAL	2.16207140292604
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	19/1080	103/9376	1.60143833153542	CD14/LAMA2/PLCB1/LAMC3/COL3A1/CXCL8/GNAS/ITGB2/SERPINB9/ITGAM/COL1A1/SERPINB6/TLR2/PRDX1/PRKCB/GNA15/TNF/TLR4/PLCB2	2.2144339459287
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	20/1080	110/9376	1.57845117845118	BMP5/DCN/PITX2/ID1/SMAD6/ID2/BMP4/BMP6/BAMBI/IGSF1/ID3/SMAD9/NRROS/SMAD5/RBX1/BMP7/HDAC2/TNF/ACVR2A/SKP1	2.20181106082503
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	46/1080	300/9376	1.33116049382716	AREG/CD14/HGF/IGF2/CSF1R/KDR/DUSP6/MEF2C/STMN1/IGF1/TEK/MAP3K1/DUSP9/MECOM/MKNK1/RASGRP3/MAPT/FGFR3/SOS1/EFNA5/RASGRF2/CDC42/FGFR2/ARRB2/RAC1/CACNB4/PRKCB/RAC2/MAP4K2/DUSP4/NRAS/MAP3K11/TAOK2/TNF/MAP4K4/CDC25B/CACNA1D/PDGFC/MAP2K5/KITLG/MAP4K1/KIT/GRB2/EFNA1/RPS6KA1/RAPGEF2	2.10336696907509
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/1080	70/9376	1.7362962962963	LAMA2/CCND1/ACTB/CD86/CD28/HLA-C/ITGB2/EIF4G2/RAC1/RAC2/HLA-E/ICAM1/SGCE/ITGAL	2.23091619432645
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	17/1080	91/9376	1.62181522181522	FCGR2B/LYN/SYK/INPP5D/PIK3AP1/LILRB5/VAV3/RASGRP3/VAV1/SOS1/RAC1/PTPN6/PRKCB/RAC2/NRAS/GRB2/BLNK	2.15057323057433
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	19/1080	105/9376	1.57093474426808	CD14/CCL4/CCL4L2/CXCL8/LY96/EDA/LYN/SYK/TNFRSF11A/TNFSF13B/PRKCB/VCAM1/TNF/ATM/ICAM1/TLR4/BCL2A1/PARP1/BLNK	2.12266263959994
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14/1080	71/9376	1.71184141888367	CXCL8/JAM2/LYN/ATP6V1G1/ATP6V0C/CDC42/RAC1/ATP6V0B/ATP6V1F/F11R/ADAM10/JAM3/TJP1/ATP6V0E1	2.17228790414847
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	30/1080	184/9376	1.41545893719807	GNAI2/ROBO2/SEMA3A/EPHA3/ABLIM3/MYL12A/SEMA6D/SLIT2/MYL12B/EFNB2/NRP1/NTNG1/CFL1/EFNA5/CDC42/SEMA3G/RAC1/BMP7/RAC2/EPHA7/NRAS/NCK2/PLXNC1/FES/CXCR4/PAK4/EFNA1/EPHA4/ROBO1/DPYSL2	2.05350211128168
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	17/1080	93/9376	1.58693747510952	CDH5/LEF1/MYL12A/PTPRB/ACTB/MYL12B/CTNNB1/HEG1/CDC42/WAS/ARHGAP29/RAC1/PTPN6/RAC2/RASIP1/TJP1/RADIL	2.05235405033657
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	39/1080	254/9376	1.33298337707787	HGF/AGTR1/PLCB1/ITPR2/ADRB1/KDR/GNAS/CALM1/CYSLTR1/SLC8A1/FGFR3/CALM2/MCOLN2/PTAFR/CHRM3/ADCY4/FGFR2/CALM3/RYR1/PRKCB/HRH2/ORAI1/SLC25A5/EDNRB/CHRM2/ATP2B1/GNA15/TBXA2R/GRIN2C/SLC25A6/CXCR4/CACNA1D/PDGFC/PTGFR/PLCB2/CYSLTR2/CALML4/PHKG1/ADRB2	1.94114296433552
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	26/1080	158/9376	1.42859821847164	CDKN1C/CCND1/CDK6/CCND2/YWHAB/RAD21/PCNA/RB1/RBX1/SKP2/HDAC2/YWHAE/CDK1/ANAPC11/ATM/CCNB2/CDC25B/MAD2L1/SKP1/SMC3/STAG2/AURKB/BUB1/PLK1/ANAPC13/CCNA2	1.96030522434185
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	26/1080	158/9376	1.42859821847164	WNT2/RPS6/LRP6/IGF1/ATP6V1G1/WNT3A/EIF4EBP1/FZD1/SOS1/FZD2/LAMTOR5/PRR5/SKP2/PRKCB/LAMTOR1/NRAS/ATP6V1F/LAMTOR4/FZD6/TNF/WNT2B/SLC38A9/FNIP2/GRB2/RPS6KA1/LAMTOR2	1.96030522434185
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	20/1080	115/9376	1.50982286634461	PLCB1/ITPR2/KL/GNAI2/MEF2C/NACA/LRP6/GNAS/PDE4B/ADCY4/MAFB/ARRB2/NR4A2/PRKCB/EGR1/CYP24A1/PLCB2/CREB3L1/GNA13/RUNX2	1.98473456269556
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/1080	101/9376	1.54719471947195	CYBB/AGTR1/PLCB1/COL3A1/CCND1/CXCL8/CDC42/COL1A1/RAC1/F3/PRKCB/MMP2/VCAM1/NRAS/TNF/ICAM1/EGR1/PLCB2	1.99484322321332
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	13/1080	67/9376	1.68446655610835	PLCB1/ITPR2/CALM1/PPP1CA/CALM2/CALM3/PRKCB/NRAS/GRIN2C/PLCB2/RAPGEF3/RPS6KA1/CALML4	2.02862261778082
Organismal Systems	Sensory system	hsa04744	Phototransduction	7/1080	29/9376	2.09553001277139	GNGT1/CALM1/CALM2/CALM3/RGS9/CALML4/PDE6G	2.13181886810122
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/1080	42/9376	1.86031746031746	FTL/CYBB/SLC40A1/NCOA4/FTH1/GPX4/PCBP1/PCBP2/SLC11A2	2.01610259333348
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	25/1080	155/9376	1.40023894862605	WNT2/AGTR1/PLCB1/ITPR2/CCND1/CDK6/GNAI2/LEF1/SCARB1/GNAS/CTNNB1/WNT3A/KCNK3/FZD1/FZD2/ADCY4/RB1/AXIN2/ORAI1/FZD6/WNT2B/CACNA1D/PLCB2/CREB3L1/AHR	1.81283939938428
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	34/1080	224/9376	1.31772486772487	B2M/SLC2A1/CCND1/CALR/HLA-C/MAP3K1/CCND2/NRP1/ITGB2/SPI1/CD4/TSPO/ADCY4/RB1/NRAS/RANBP1/SLC25A5/ANAPC11/SLC25A6/HLA-E/TNF/ATM/CCNB2/CANX/ICAM1/EGR1/MAD2L1/RAN/CREB3L1/MSX2/ANAPC13/FDPS/ITGAL/CCNA2	1.7365222619092
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1080	37/9376	1.87707707707708	CCND1/LEF1/NCOA4/CTNNB1/TPM3/NRAS/PPARG/TPR	1.92864181814852
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	23/1080	142/9376	1.40615545122587	TYROBP/FCGR2A/CYBA/FCGR3A/ITPR2/FCGR2B/CSF1R/NCF4/SYK/LCP2/FCGR1A/SPI1/LILRB5/TNFRSF11A/RAC1/NCF2/SIRPA/TNF/TEC1/CALCR/PPARG/GRB2/BLNK	1.75956237914981
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/1080	78/9376	1.55821462488129	ELMO1/ARPC3/ARPC1B/ACTB/CLTA/CTNNB1/HCLS1/CLTC/CDC42/RAC1/ARPC5/ARPC2/ACTR2/RHOG	1.78614571164538
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	31/1080	203/9376	1.32574347746762	SPP1/HGF/LAMA2/LAMC3/CCND1/KDR/MYL12A/ACTB/IGF1/VTN/MYL12B/ITGA9/CTNNB1/CCND2/VAV3/ITGA4/VAV1/PPP1CA/SOS1/ITGA6/CDC42/COL1A1/ITGA2/RAC1/PRKCB/RAC2/COL6A6/PDGFC/PAK4/GRB2/PARVB	1.69289957055856
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	17/1080	100/9376	1.47585185185185	CXCL14/CCL3/CCL4/CCL4L2/CCL3L1/CSF1R/ACKR3/TNFSF10/CXCL8/IL6ST/CCR1/IL10RA/TNFRSF1B/CX3CR1/IL10RB/TNF/CXCR4	1.72605463371643
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	23/1080	144/9376	1.38662551440329	WNT2/ID1/IL6ST/ID2/IGF1/CTNNB1/DUSP9/BMP4/WNT3A/KLF4/ID3/FZD1/SMAD9/FGFR3/FZD2/FGFR2/SMAD5/AXIN2/NRAS/FZD6/WNT2B/ACVR2A/GRB2	1.68689093036033
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	15/1080	86/9376	1.51421188630491	LAMA2/GJA1/LEF1/ACTB/ITGA9/CTNNB1/DSP/ITGA4/SLC8A1/ITGA6/DSC2/ITGA2/CACNB4/CACNA1D/SGCE	1.72840941870923
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	19/1080	115/9376	1.43433172302738	GNGT1/PLCB1/ITPR2/GNG2/GNG11/GNAI2/GNG10/GNAS/GNG5/GNB2/KCNJ5/PRKCB/NRAS/ALOX5/SLC6A4/CACNA1D/PLCB2/GNB4/RAPGEF3	1.69084840887633
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/1080	52/9376	1.66951566951567	HSD17B2/SCARB1/IGF1/GNAS/HSD17B1/BMP6/CGA/ADCY4/CYP19A1/ALOX5	1.74672457093662
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	10/1080	52/9376	1.66951566951567	CD36/PLTP/LIPG/NPC2/SCARB1/MYLIP/TSPO/APOC1/LRP2/LRP1	1.74672457093662
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	11/1080	59/9376	1.61858129315756	ADRB1/GNAI2/PDE3B/GNAS/CGA/ADCY4/PLAAT3/FABP4/NPR1/ADRB2/ADORA1	1.71968096636806
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	14/1080	80/9376	1.51925925925926	HGF/KDR/RPS6/IGF1/EIF4EBP1/FGFR3/SOS1/FGFR2/PRKCB/NRAS/GAS6/PDGFC/GRB2/NRG2	1.68284582525825
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	18/1080	109/9376	1.43363914373089	SPP1/CD14/CCL3/CCL4/CCL4L2/CCL3L1/CXCL8/LY96/CD86/TLR1/TLR7/RAC1/TLR2/IRF5/TLR6/TNF/TLR4/TLR8	1.64299139890211
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	20/1080	125/9376	1.38903703703704	FCER1G/PLCB1/GNAI2/ASAH1/DEGS1/S1PR1/RAC1/SPTLC2/PRKCB/RAC2/CERS2/NRAS/CTSD/TNF/S1PR5/PLCB2/SPTLC3/SGMS1/GNA13/ADORA1	1.57984601556356
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	17/1080	103/9376	1.43286587558432	C1QA/CCL3/C1QC/C1QB/PLCB1/CCL3L1/GNAI2/CXCL8/CALR/GNAS/TLR2/GNA15/TLR6/TNF/TLR4/PLCB2/ACE	1.59376753803
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	47/1080	333/9376	1.22531420309198	SPP1/WNT2/LAMA2/RBPJ/LAMC3/CCND1/CDK6/GNAS/VTN/ATP6V1G1/ITGA9/HLA-C/CTNNB1/CCND2/WNT3A/EIF4EBP1/ATP6V0C/FZD1/ITGA4/SOS1/HEY1/ITGA6/MFNG/CDC42/FZD2/RB1/COL1A1/ITGA2/MAML3/AXIN2/ATP6V0B/LLGL2/HDAC2/NRAS/ATP6V1F/COL6A6/PTGER4/FZD6/HLA-E/NOTCH4/TNF/ATM/WNT2B/GRB2/CREB3L1/ATP6V0E1/CCNA2	1.51048899237267
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	15/1080	89/9376	1.46317103620474	SPP1/CD36/LAMA2/LAMC3/VTN/ITGA9/FREM1/ITGA4/ITGA6/COL1A1/ITGA2/SDC1/COL6A6/HMMR/CD47	1.58402422215668
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	15/1080	89/9376	1.46317103620474	GNGT1/GNG2/GNG11/GNAI2/GNG10/GNG5/GABARAP/GABARAPL2/ADCY4/GNB2/PRKCB/SLC12A5/GABRA3/CACNA1D/GNB4	1.58402422215668
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	14/1080	82/9376	1.48220415537489	LGMN/B2M/CALR/CTSS/HLA-C/HSPA2/CTSL/CD4/HLA-E/TNF/PDIA3/CD74/CANX/HSPA5	1.58233955617859
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	24/1080	157/9376	1.32710544939844	ITPR2/CCND1/CDK6/GATA4/CXCL8/HLA-C/CCND2/CALM1/EIF4EBP1/ZFP36L1/PPP1CA/CALM2/CALM3/RB1/NRAS/CDK1/SLC25A5/SLC25A6/HLA-E/ATM/CCNB2/CACNA1D/CALML4/CCNA2	1.49127879411496
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	17/1080	105/9376	1.40557319223986	LAMA2/ADRB1/ACTB/IGF1/GNAS/ITGA9/ITGA4/TPM3/SLC8A1/ITGA6/ADCY4/ITGA2/CACNB4/TNF/TNNT2/CACNA1D/SGCE	1.50786945694551
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/1080	69/9376	1.50982286634461	GNAS/CALM1/PPP1CA/CALM2/CALM3/PRKCB/HDAC2/GRIN2C/CACNA1D/GRIA4/CREB3L1/CALML4	1.53356484031293
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/1080	55/9376	1.57845117845118	ASAH1/PLPP3/DEGS1/SPTLC2/CERS2/B4GALT6/HEXA/SPTLC3/SGMS1/PSAP	1.55231532563335
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	17/1080	106/9376	1.39231306778477	FOLR2/CCND1/LEF1/IGF1/CTNNB1/SOS1/GSTP1/SPINT1/FGFR2/ERG/RB1/ETV5/HSP90B1/NRAS/PDGFC/GRB2/CREB3L1	1.46557815940087
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	11/1080	63/9376	1.51581422692534	PTGDS/HPGDS/PLA2G2A/LTC4S/TBXAS1/GPX4/PLAAT3/ALOX5/HPGD/CBR1/PRXL2B	1.48211510684694
NA	NA	hsa04082	Neuroactive ligand signaling	29/1080	199/9376	1.26514051740182	GNGT1/PLCB1/GNG2/GNG11/ADRB1/GNAI2/P2RY1/GNG10/GNAS/GNG5/TAC3/OGFRL1/CHRM3/ADCY4/P2RY13/GNB2/PRKCB/HRH2/CHRM2/GRIN2C/GABRA3/SLC1A3/SLC6A4/GRIA4/PLCB2/GRIK4/GNB4/ADRB2/ADORA1	1.36400328433953
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	21/1080	138/9376	1.32109500805153	ITPR2/IGF1/CALM1/YWHAB/PPP1CA/CALM2/ADCY4/CALM3/RBX1/YWHAE/CDK1/ANAPC11/CCNB2/MAD2L1/SKP1/SMC3/RPS6KA1/CALML4/BUB1/PLK1/ANAPC13	1.37103096112321
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	5/1080	23/9376	1.88727858293076	AGTR1/PRCP/ANPEP/MME/ACE	1.53713352181391
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	21/1080	139/9376	1.31159072741807	PLCB1/ITPR2/GNAI2/KRT18/GNAS/CALM1/KRT23/SOS1/CALM2/ADCY4/CALM3/HSP90B1/KCNJ5/MMP2/NRAS/CTSD/KRT19/PLCB2/GRB2/CREB3L1/CALML4	1.33533304867212
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	11/1080	65/9376	1.46917378917379	AGTR1/PLCB1/ITPR2/SCARB1/GNAS/KCNK3/ADCY4/ORAI1/CACNA1D/PLCB2/CREB3L1	1.36947907590098
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	11/1080	65/9376	1.46917378917379	SPP1/PLCB1/ITPR2/CGA/KISS1/ARRB2/KCNJ5/PRKCB/NRAS/CACNA1D/PLCB2	1.36947907590098
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1080	17/9376	2.04270152505447	CD209/PCDH11X/MYH10/CLEC4M	1.55250457997718
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	22/1080	148/9376	1.29049049049049	WNT2/CCND1/CDK6/LEF1/LRP6/IGF1/CTNNB1/WNT3A/FZD1/SOS1/HEY1/FZD2/DLL4/RB1/AXIN2/JAG2/NRAS/FZD6/NOTCH4/WNT2B/KIT/GRB2	1.28520417857879
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	9/1080	51/9376	1.53202614379085	ENPP2/PLA2G2A/PLPP3/LPCAT2/PLAAT3/CEPT1/PLD3/PLD4/TMEM86A	1.37453811214593
NA	NA	hsa04081	Hormone signaling	31/1080	219/9376	1.22888550651108	GNGT1/AGTR1/PLCB1/GNG2/SLC16A10/GNG11/SLC40A1/ADRB1/CSH1/IGF2/GNAI2/RAMP2/PRLR/IGF1/GNG10/GNAS/CGA/GNG5/SMAD9/ADCY4/SMAD5/GNB2/ADIPOR1/GNA15/CALCR/PLCB2/GNB4/RAPGEF3/NPR1/ADRB2/GNA13	1.2365932960548
NA	NA	hsa04981	Folate transport and metabolism	6/1080	31/9376	1.68028673835125	FOLR2/SLCO2B1/TYMS/ABCG2/SHMT1/MTHFS	1.36882000321462
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	16/1080	105/9376	1.32289241622575	FCER1G/ITPR2/SYK/CLEC7A/CALM1/LSP1/CD209/PYCARD/CALM2/NLRP3/CALM3/CASP1/NRAS/CLEC4M/TNF/CALML4	1.2004728656183
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1080	61/9376	1.42319368548877	FTL/SLC40A1/ATP1B1/FTH1/ATOX1/SLC8A1/ATP2B1/ATP7B/ATP1B3/SLC11A2	1.19639836560122
Human Diseases	Cancer: specific types	hsa05214	Glioma	12/1080	76/9376	1.37076023391813	CCND1/CDK6/IGF1/CALM1/SOS1/CALM2/CALM3/RB1/PRKCB/NRAS/GRB2/CALML4	1.17090487348824
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	15/1080	99/9376	1.31537598204265	LAMA2/ACTB/IGF1/ITGA9/ITGA4/TPM3/SLC8A1/ITGA6/ITGA2/CACNB4/TNF/TNNT2/CACNA1D/SGCE/ACE	1.13816592444163
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/1080	19/9376	1.82768031189084	HPSE2/HYAL2/HEXA/HYAL4	1.30296951461901
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	10/1080	62/9376	1.40023894862605	RBPJ/HEY1/MFNG/DLL4/APH1A/MAML3/JAG2/HDAC2/DTX4/NOTCH4	1.1408018617105
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/1080	70/9376	1.3642328042328	HGF/SLC2A1/ELOB/SOS1/CDC42/EPAS1/RAC1/RBX1/NRAS/PAK4/GRB2	1.10359493257713
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	26/1080	187/9376	1.20705090116855	CYBB/CYBA/PLCB1/ITPR2/CARD16/CARD18/CXCL8/GPSM3/GABARAP/GABARAPL2/PYCARD/TRPM2/PKN2/NLRP3/CASP1/CARD8/TANK/YWHAE/GBP4/TNF/TXN2/TLR4/PLCB2/OAS3/RIPK3/IFI16	1.0318746583754
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/1080	63/9376	1.37801293356849	WNT2/LEF1/CTNNB1/BMP4/WNT3A/FZD1/FZD2/AXIN2/FZD6/WNT2B	1.08616368099223
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/1080	41/9376	1.48220415537489	CCND1/CXCL8/FGFR3/RB1/MMP1/MMP2/NRAS	1.11642321853668
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	12/1080	79/9376	1.31870604781997	SYT1/ATP6V1G1/CLTA/CLTC/ATP6V0C/AP2S1/ATP6V0B/ATP6V1F/SLC1A3/SLC6A4/ATP6V0E1/STX3	1.02635021875519
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	13/1080	87/9376	1.29723286504896	AREG/CCND1/LEF1/CTNNB1/PMAIP1/SOS1/RAC1/AXIN2/RAC2/NRAS/BIRC5/GRB2/MSH2	1.00492839294272
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	15/1080	103/9376	1.26429341963323	SLC16A10/DPP4/COL3A1/COL15A1/ATP1B1/COL8A2/KCNQ1/SLC8A1/PRCP/COL1A1/MME/COL6A6/ATP1B3/COL14A1/KCNE3	0.97310113013129
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/1080	28/9376	1.55026455026455	ATP6V1G1/ATP6V0C/ATP6V1F/SLC4A1/ATP6V0E1	1.05209351385675
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1080	21/9376	1.65361552028219	ENPP1/VNN2/BCAT1/PPCS	1.08186545055498
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	39/1080	298/9376	1.13616703952274	CXCL14/BMP5/CCL3/CCL4/CCL4L2/CSH1/CCL3L1/CSF1R/ACKR3/TNFSF10/CXCL8/IL12RB2/EDA/IL6ST/PRLR/IL33/CCR1/BMP4/BMP6/TNFRSF11A/TNFSF13B/CD4/TNFRSF19/IL10RA/CSF3R/GDF15/BMP7/TNFRSF1B/TNFRSF25/CX3CR1/CSF2RA/IL10RB/ACVRL1/TNF/CXCR4/ACVR2A/CSF2RB/TNFSF8/CNTFR	0.861882737588231
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	31/1080	233/9376	1.15504689238595	LAMA2/TNNT3/DCN/COL3A1/ATP1B1/NEBL/ACTB/ITGA9/FBLN1/DSP/ITGA4/TPM3/FMNL2/FBN2/ITGA6/DSC2/COL1A1/ITGA2/NID2/FBLN2/SDC1/MYH10/SPTBN1/COL6A6/TNNT1/ATP1B3/MYL4/TNNT2/SGCE/ANK3/CAPZA1	0.86468875460299
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	19/1080	137/9376	1.20400108137334	ITPR2/TNFSF10/CTSC/TUBA1B/ACTB/CTSS/PMAIP1/CTSL/CTSZ/CASP10/NRAS/BIRC5/CTSD/CTSO/TNF/ATM/CSF2RB/BCL2A1/PARP1	0.867847494186935
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	30/1080	226/9376	1.15240904621436	ADRB1/GNAI2/ATP1B1/PDE3B/GNAS/CALM1/CGA/VAV3/VAV1/PPP1CA/PDE4B/CALM2/ADCY4/CALM3/RAC1/RAC2/ORAI1/CHRM2/ATP2B1/GRIN2C/ATP1B3/CACNA1D/GRIA4/RAPGEF3/NPR1/CREB3L1/CALML4/ARAP3/ADRB2/ADORA1	0.836792081873764
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	9/1080	59/9376	1.32429378531073	HPGDS/MGST2/LAP3/IDH1/GPX7/GPX4/GSTP1/ANPEP/GGCT	0.901549814517696
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1080	29/9376	1.49680715197957	RASSF4/WWC1/RASSF6/AJUBA/MOB1A	0.966749288518739
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	17/1080	122/9376	1.20971463266545	PLCB1/SLC16A10/SLC2A1/CCND1/GATA4/ATP1B1/ACTB/CTNNB1/BMP4/TBC1D4/PRKCB/HDAC2/NRAS/ATP1B3/NOTCH4/MED30/PLCB2	0.841215073467836
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	14/1080	99/9376	1.22768424990647	PLCB1/ITPR2/IGF1/GNAS/CALM1/PPP1CA/PRKCH/CALM2/ADCY4/CALM3/PRKCB/PTGER4/PLCB2/CALML4	0.821693691121203
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/1080	99/9376	1.22768424990647	EIF4EBP1/PLPP3/SOS1/WAS/LYPLA1/SLC22A3/RAC1/PRKCB/RAC2/NRAS/SLC44A4/SLC44A2/PDGFC/GRB2	0.821693691121203
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	33/1080	253/9376	1.13236714975845	CD14/PLCB1/ELMO1/ITPR2/UBA52/RPS27A/UBB/CXCL8/ARPC3/MYL12A/ARPC1B/ACTB/MYL12B/PFN1/CYTH4/HCLS1/PYCARD/CDC42/NLRP3/RAC1/CASP1/RBX1/ARPC5/ARF6/ARPC2/ARF1/ACTR2/TNF/ATM/TLR4/PLCB2/CYTH1/SKP1	0.770078121215609
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	5/1080	30/9376	1.44691358024691	FOLR2/TYMS/ABCG2/SHMT1/TNF	0.884574539306625
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1080	38/9376	1.37076023391813	ATP1B1/IGF1/NEDD4L/PRKCB/NR3C2/ATP1B3	0.826268421761655
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/1080	23/9376	1.50982286634461	PCNA/SSBP1/RPA3/MSH2	0.883224088940623
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1080	23/9376	1.50982286634461	ATP1B1/SLC4A4/CA4/ATP1B3	0.883224088940623
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	19/1080	142/9376	1.16160667709963	UBA52/RPS27A/WWP1/UBB/MAP3K1/ELOB/UBE2C/NEDD4L/RBX1/SKP2/ANAPC11/UBE2E3/RNF7/NEDD4/KLHL9/PIAS2/SKP1/CDC34/ANAPC13	0.700118706730811
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1080	16/9376	1.62777777777778	FUT9/NAGA/HEXA	0.906757485750031
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/1080	31/9376	1.40023894862605	ACSS1/SHMT1/AFMID/GCSH/GLDC	0.805329647131888
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	15/1080	110/9376	1.18383838383838	GNAI2/PDE3B/IGF1/ADCY4/CDK1/ANAPC11/STK10/CCNB2/CDC25B/MAD2L1/RPS6KA1/BUB1/PLK1/ANAPC13/CCNA2	0.699760674744161
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	14/1080	102/9376	1.19157588961511	PLCB1/ITPR2/ATP1B1/PLA2G2A/GNAS/KCNQ1/SLC4A4/CHRM3/ADCY4/RAC1/PRKCB/ATP2B1/ATP1B3/PLCB2	0.701892392491416
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	12/1080	86/9376	1.21136950904393	PLCB1/SLC2A1/ATP1B1/GNAS/CHRM3/ADCY4/KCNMB4/PRKCB/ATP1B3/CACNA1D/PLCB2/CREB3L1	0.710471811308619
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	16/1080	120/9376	1.15753086419753	MAP3K1/CALM1/BEX3/SOS1/CALM2/CDC42/CALM3/RAC1/ARHGDIG/NRAS/YWHAE/SH2B3/MAP2K5/GRB2/RPS6KA1/CALML4	0.626625046445884
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1080	17/9376	1.53202614379085	CA8/CA4/CA1	0.792147134204823
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	22/1080	170/9376	1.12348583877996	HGF/WNT2/CCND1/CDK6/IGF2/MGST2/LEF1/ACTB/LRP6/CTNNB1/WNT3A/FZD1/SOS1/GSTP1/FZD2/RB1/AXIN2/PRKCB/NRAS/FZD6/WNT2B/GRB2	0.586231668743826
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/1080	33/9376	1.31537598204265	VAMP8/VAMP5/STX7/BET1/STX3	0.654795303273044
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/1080	73/9376	1.18924403855911	HGF/CCND1/CDK6/RARB/SOS1/RB1/PRKCB/NRAS/EML4/GRB2	0.585646121353053
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	26/1080	205/9376	1.10106594399277	RBPJ/CCND1/CDK6/LYN/IL6ST/SYK/HLA-C/CCND2/PMAIP1/HNRNPK/YWHAB/CDC42/SCIN/RB1/RAC1/SKP2/HDAC2/NRAS/RANBP1/YWHAE/CDK1/HLA-E/DDX3X/GRB2/CREB3L1/CCNA2	0.527881649243343
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	7/1080	49/9376	1.24021164021164	ST6GAL1/ST6GAL2/MFNG/GALNT1/C1GALT1/FUT11/GXYLT2	0.608252978924931
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1080	18/9376	1.44691358024691	FUCA1/MANBA/HEXA	0.684749033652034
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	14/1080	107/9376	1.13589477327795	PLCB1/ITPR2/SLC2A1/PDE3B/GNAS/CALM1/CALM2/CALM3/PPP4C/PLCB2/CREB3L1/CALML4/PHKG1/PYGL	0.510083582311183
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/1080	83/9376	1.15055778670237	CCL4/CCL4L2/IL33/PYCARD/PCBP1/NLRP3/CASP1/POLR2K/RIPK3/IFI16/POLR2L	0.497081320742654
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	17/1080	133/9376	1.10966304650515	CCND1/TNFSF10/IGF1/KLF2/CCND2/GABARAP/CCNG2/GABARAPL2/SOS1/S1PR1/SKP2/NRAS/ATM/CCNB2/PLK2/GRB2/PLK1	0.459560607528685
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/1080	76/9376	1.14230019493177	CD36/PLTP/FABP5/MMP1/FABP4/DBI/NR1H3/OLR1/PPARG/SLC27A2	0.449400924104318
Cellular Processes	Cell motility	hsa04814	Motor proteins	24/1080	194/9376	1.07399770904926	TNNT3/TUBA1B/MYL12A/ACTB/MYO10/DNAH8/MYL12B/KIF26B/TPM3/DYNLL1/MYO1F/DYNLRB1/MYO7A/TUBB2B/MYH10/TNNT1/TUBB/KIF20B/MYL4/MYL6B/TNNT2/DCTN6/KIF26A/CAPZA1	0.375762675369316
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/1080	44/9376	1.18383838383838	CD86/CD28/HLA-C/ICA1/HLA-E/TNF	0.440999717052585
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1080	28/9376	1.24021164021164	ELOVL2/HACD4/HACD3/ACAA2	0.45927928393362
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	15/1080	122/9376	1.06739526411658	PTPRC/LCP2/CD28/VAV3/VAV1/SOS1/CD4/CDC42/PTPN6/NRAS/NCK2/TNF/TEC1/PAK4/GRB2	0.270338370454342
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	15/1080	122/9376	1.06739526411658	PLCB1/ITPR2/CSH1/GNAI2/IGF1/GNAS/MAP3K1/SOS1/ADCY4/PRKCB/NRAS/CACNA1D/PLCB2/GRB2/CREB3L1	0.270338370454342
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/1080	46/9376	1.13236714975845	POMP/PSMA1/PSMA4/PSMB1/PSMA7/PSMA2	0.324699377177163
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1080	21/9376	1.24021164021164	CSGALNACT1/CHST14/B3GALT6	0.397598689599535
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	18/1080	150/9376	1.04177777777778	HGF/WNT2/CCND1/LEF1/LRP6/CTNNB1/WNT3A/FZD1/RARB/SOS1/FZD2/FGFR2/RB1/AXIN2/NRAS/FZD6/WNT2B/GRB2	0.186100433226132
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	7/1080	56/9376	1.08518518518519	CCND1/CCND2/DISP1/ARRB2/LRP2/GRK3/SCUBE2	0.230681769141811
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	12/1080	99/9376	1.05230078563412	CCND1/IGF1/GNAS/SOS1/ADCY4/DLL4/RB1/JAG2/MMP2/NRAS/NOTCH4/GRB2	0.188749224480355
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/1080	39/9376	1.11301044634378	TYMS/SHMT1/GCSH/MTHFS/GLDC	0.255158686932809
Human Diseases	Immune disease	hsa05330	Allograft rejection	5/1080	39/9376	1.11301044634378	CD86/CD28/HLA-C/HLA-E/TNF	0.255158686932809
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1080	22/9376	1.18383838383838	HNMT/ASPA/CNDP2	0.311466968037114
NA	NA	hsa03272	Virion - Hepatitis viruses	6/1080	48/9376	1.08518518518519	DPP4/SCARB1/CD63/CLDN11/CD9/OCLN	0.213478216623225
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1080	48/9376	1.08518518518519	PLCB1/ATP1B1/PRKCB/ATP1B3/CACNA1D/PLCB2	0.213478216623225
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/1080	75/9376	1.04177777777778	CCND1/CDK6/IGF1/CCND2/PMAIP1/CCNG2/CDK1/ATM/CCNB2	0.131061245025194
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1080	23/9376	1.13236714975845	FUT9/B4GAT1/LARGE2	0.229314656067338
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/1080	41/9376	1.05871725383921	GATM/ALAS2/SHMT1/GCSH/GLDC	0.135945127772357
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/1080	59/9376	1.0300062774639	CCND1/LEF1/CTNNB1/SOS1/AXIN2/NRAS/GRB2	0.0834186626673361
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1080	15/9376	1.15753086419753	ST3GAL5/HEXA	0.220299396116017
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	13/1080	112/9376	1.00767195767196	LAMA2/LAMC3/GNAI2/LY96/ITGA6/TLR2/IL10RA/PIK3R5/PIK3CG/ALOX5/IL10RB/TNF/TLR4	0.0294699283841647
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1080	24/9376	1.08518518518519	HS3ST3A1/NDST3/B3GALT6	0.150758076561276
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	18/1080	156/9376	1.0017094017094	CCND1/CDK6/SCARB1/CTNNB1/YWHAB/SOS1/EIF3E/RB1/NRAS/YWHAE/CLDN11/IFIT1/TNF/OCLN/NR1H3/GRB2/OAS3/RSAD2	0.0077679087780723
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	20/1080	174/9376	0.997871434653044	MAN1A1/CALR/RPN2/TUSC3/TRAM1/RBX1/HSP90B1/TMEM258/SEC61G/HERPUD1/PDIA3/SEC61B/CANX/HSPA5/KRTCAP2/P4HB/OSTC/SKP1/TXNDC5/DDOST	-0.0102254785371255
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/1080	42/9376	1.03350970017637	IDO2/IDO1/INMT/KYNU/AFMID	0.0785279812901516
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	8/1080	71/9376	0.978195096504956	CCND1/PRLR/CCND2/CGA/TNFRSF11A/SOS1/NRAS/GRB2	-0.0665408430260924
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/1080	44/9376	0.986531986531987	GNAS/DYNLL1/ARHGDIG/DCTN6/CREB3L1	-0.032307671578944
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	11/1080	98/9376	0.974452003023431	PLCB1/ITPR2/INPP5D/CALM1/CALM2/CALM3/PRKCB/CDS1/PIK3C2A/PLCB2/CALML4	-0.0917288299947783
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	23/1080	205/9376	0.974019873532069	B2M/RBPJ/CCND1/CDK6/LYN/SYK/CALR/HLA-C/CCND2/RB1/RAC1/TLR2/SKP2/HDAC2/HLA-E/TNF/PDIA3/NEDD4/ICAM1/OAS3/BLNK/ITGAL/CCNA2	-0.135697856920259
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1080	17/9376	1.02135076252723	INMT/PAPSS2	0.0317896884324622
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/1080	45/9376	0.964609053497942	CD86/CD28/HLA-C/HLA-E/TNF	-0.0858613048154516
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	20/1080	180/9376	0.964609053497942	B2M/SYK/CALR/HLA-C/BST2/EIF4EBP1/SRSF9/POU2F2/PPP1CA/SRSF8/TLR2/SRSF3/HLA-E/TNF/SRSF6/PDIA3/CD74/ALYREF/SRSF5/OAS3	-0.172978486613251
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/1080	73/9376	0.951395230847286	PPIA/BST2/CD4/TRIM5/SERINC3/CXCR4/RAN/SERINC5	-0.150415277280489
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/1080	27/9376	0.964609053497942	ELOVL2/HACD4/HACD3	-0.0664438247510239
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	24/1080	217/9376	0.960163850486431	ADRB1/CCND1/GNAI2/MGST2/GNAS/KLF4/EIF4EBP1/SOS1/ADCY4/PAQR7/DLL4/RB1/ARRB2/HSP90B1/PRKCB/PAQR8/NRAS/BIRC5/CACNA1D/GRB2/CREB3L1/RPS6KA1/AHR/ADRB2	-0.214213252507412
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	14/1080	128/9376	0.949537037037037	ENPP1/PDE3B/GUCY1A2/PDE4B/DCK/ADCY4/GUCY1A1/GUCY1B1/PAPSS2/NPR1/PDE9A/PDE6G/ADA2/GUK1	-0.207403922337177
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/1080	46/9376	0.943639291465378	FTL/BLVRB/FTH1/ALAS2/FECH	-0.138253992715337
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	12/1080	110/9376	0.947070707070707	CYBB/SLC2A1/RPS6/IGF1/TEK/EIF4EBP1/MKNK1/ELOB/EPAS1/RBX1/PRKCB/TLR4	-0.201469556904363
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	15/1080	138/9376	0.943639291465378	RPS6/PDE3B/CALM1/EIF4EBP1/MKNK1/PPP1CA/SOS1/CALM2/CALM3/PRKAR1A/NRAS/GRB2/CALML4/PHKG1/PYGL	-0.240652375322529
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	8/1080	75/9376	0.926024691358025	MGST2/PMAIP1/GSTP1/TOP2A/BIRC5/ATP7B/ATM/MSH2	-0.232068256557612
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/1080	38/9376	0.913840155945419	ENPP1/NMRK1/QPRT/NADK2	-0.192014007580784
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/1080	38/9376	0.913840155945419	PTPRC/CD4/ORAI1/BLNK	-0.192014007580784
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/1080	19/9376	0.913840155945419	GCSH/GLDC	-0.135636487390863
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	11/1080	104/9376	0.918233618233618	PLA2G2A/PLPP3/LPCAT2/LYPLA1/PLAAT3/CEPT1/PLA2G15/CDS1/PLD3/PLD4/SGMS1	-0.302529606638422
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	18/1080	168/9376	0.93015873015873	FTL/CYBB/TNFSF10/PPIA/IL33/FTH1/CHMP5/PYCARD/HMGB1/NLRP3/CASP1/SLC25A5/SLC25A6/TNF/TLR4/PARP1/RIPK3/PYGL	-0.329569684952331
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/1080	86/9376	0.908527131782946	AREG/EIF4EBP1/SOS1/PRKCB/NRAS/NCK2/PAK4/GRB2/NRG2	-0.307465796091994
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/1080	77/9376	0.901972101972102	CCND1/CDK6/MECOM/SOS1/RB1/HDAC2/NRAS/GRB2	-0.311630583834196
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1080	49/9376	0.885865457294029	GNAI2/GNAS/GRIN2C/RGS9/CREB3L1	-0.289006292692463
Genetic Information Processing	Transcription	hsa03040	Spliceosome	26/1080	243/9376	0.928882792257278	HNRNPA1/SRSF9/HNRNPK/LSM3/SNRPE/PCBP1/LSM6/SRSF8/HNRNPA3/LSM4/SNRPF/SRSF3/SNRPG/SNRPD3/CWC15/SRSF6/SNRPB2/LSM7/SNRPC/SNU13/ALYREF/SRSF5/SF3B6/MAGOH/LSM8/LSM5	-0.405260474817321
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1080	20/9376	0.868148148148148	SQLE/CYP24A1	-0.212970411154116
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/1080	78/9376	0.890408357075024	LSM3/LSM6/PABPC4L/LSM4/LSM7/EXOSC6/LSM8/LSM5	-0.350665558223675
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/1080	50/9376	0.868148148148148	CD86/CD28/ITGA4/TNFSF13B/CXCR4	-0.337276959934519
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/1080	60/9376	0.868148148148148	KDR/CDC42/RAC1/PRKCB/RAC2/NRAS	-0.369666642746344
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	17/1080	163/9376	0.905430583958191	CXCL8/MAP3K1/YWHAB/SOS1/PCNA/RB1/TLR2/PRKCB/CASP10/NRAS/BIRC5/TNF/TLR4/DDX3X/GRB2/CREB3L1/CCNA2	-0.439447621480059
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1080	10/9376	0.868148148148148	PAPSS2	-0.150512407099566
Human Diseases	Substance dependence	hsa05034	Alcoholism	20/1080	191/9376	0.90905565251115	GNGT1/GNG2/GNG11/GNAI2/GNG10/GNAS/CALM1/GNG5/PPP1CA/SOS1/CALM2/CALM3/GNB2/HDAC2/NRAS/GRIN2C/GRB2/GNB4/CREB3L1/CALML4	-0.4581587222001
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	18/1080	173/9376	0.903275529865125	CDK6/TNFSF10/CXCL8/ACTB/IL33/PYCARD/TLR7/NLRP3/CASP1/PRKCB/SLC25A5/SLC25A6/TNF/ICAM1/TLR4/OAS3/RSAD2/FDPS	-0.463295246309046
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	11/1080	109/9376	0.876112810057764	CD36/SLC2A1/PPP1CA/TBC1D4/PRKCB/TNF/NR1H3/SLC27A2/CREB3L1/RPS6KA1/PYGL	-0.469389330857005
Human Diseases	Immune disease	hsa05310	Asthma	3/1080	32/9376	0.813888888888889	FCER1G/PRG2/TNF	-0.380490677487824
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/1080	62/9376	0.840143369175627	IGF1/ADCY4/EIF4EBP2/HDAC2/NRAS/SOD1	-0.455639668945866
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/1080	72/9376	0.8440329218107	CXCL8/MAP3K1/TANK/CASP10/RNF125/TNF/DDX3X	-0.479322127154113
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1080	43/9376	0.807579672695952	CD36/SCARB1/PLA2G2A/PLPP3	-0.456286572006642
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	6/1080	63/9376	0.826807760141093	PCNA/GTF2H5/RBX1/POLR2K/RPA3/POLR2L	-0.49764202242661
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/1080	73/9376	0.832470826991375	HGF/CCND1/CDK6/IGF1/RB1/NRAS/PDGFC	-0.51844597659726
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	9/1080	93/9376	0.840143369175627	LAMA2/LAMC3/CCND1/CDK6/RARB/ITGA6/RB1/ITGA2/SKP2	-0.558973344962071
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/1080	54/9376	0.803840877914952	CD86/CD28/HLA-C/CGA/HLA-E	-0.521571658048624
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/1080	34/9376	0.766013071895425	BHLHE41/RBX1/SKP1	-0.493144583219436
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1080	12/9376	0.723456790123457	GGCX	-0.345848633631127
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	14/1080	144/9376	0.8440329218107	C1QA/CD14/C1QC/C1QB/CCND1/CXCL8/LEF1/LY96/C3AR1/CTNNB1/C2/ADIPOR1/TNF/TLR4	-0.680502035770694
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	14/1080	144/9376	0.8440329218107	PLCB1/ITPR2/RBPJ/PSMA1/RYR1/PRKCB/PSMA4/SLC25A5/PSMB1/GRIN2C/SLC25A6/PSMA7/PSMA2/PLCB2	-0.680502035770694
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/1080	36/9376	0.723456790123457	PCNA/SSBP1/RPA3	-0.599796539761473
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	38/1080	370/9376	0.891611611611612	AGTR1/SPX/ADRB1/APLNR/APLN/CSH1/NR3C1/LPAR6/LYPD6/PRLR/P2RY1/C3AR1/CGA/TAC3/KISS1/CYSLTR1/OGFRL1/TSPO/PTAFR/CHRM3/S1PR1/P2RY13/HRH2/FPR1/EDNRB/CHRM2/PTGER4/TBXA2R/GRIN2C/GABRA3/S1PR5/GRIA4/CALCR/PTGFR/CYSLTR2/GRIK4/ADRB2/ADORA1	-0.767504258508946
Human Diseases	Infectious disease: viral	hsa05162	Measles	13/1080	136/9376	0.829847494553377	FCGR2B/CCND1/CDK6/CD28/RACK1/CCND2/CD209/TLR7/TLR2/CLEC4M/SLAMF1/TLR4/OAS3	-0.721165531438956
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/1080	108/9376	0.803840877914952	SUMO2/EEF1A1/SAP18/SUMO1/ALYREF/RAN/MAGOH/NUP50/TMEM33/TPR	-0.739759444642947
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1080	26/9376	0.667806267806268	PLA2G2A/PLAAT3	-0.61197748818589
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/1080	26/9376	0.667806267806268	HHEX/RFX6	-0.61197748818589
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/1080	59/9376	0.735718769617075	ENPP1/DCK/TYMS/DUT/CMPK2	-0.734712489183024
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	16/1080	168/9376	0.826807760141093	CCND1/CSH1/IL12RB2/IL6ST/PRLR/CCND2/SOS1/IL10RA/PTPN6/CSF3R/CSF2RA/IL10RB/CSF2RB/GRB2/PIAS2/CNTFR	-0.817266238947448
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/1080	90/9376	0.771687242798354	KL/IGF1/EIF4EBP1/ADCY4/NRAS/ADIPOR1/PPARG/CREB3L1	-0.78523606513087
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1080	90/9376	0.771687242798354	SLC2A1/ATP1B1/SCARB1/GNAS/SLC4A4/ADCY4/ABCG2/ATP1B3	-0.78523606513087
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/1080	38/9376	0.685380116959064	UXS1/HEXA/RENBP	-0.701155222252004
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/1080	71/9376	0.733646322378717	SLC2A1/IDH1/FGFR3/FGFR2/NRAS/KIT	-0.812817092084279
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1080	28/9376	0.62010582010582	FUT9/B3GNT5	-0.726349175912641
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1080	28/9376	0.62010582010582	AKR1B1/CBR1	-0.726349175912641
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/1080	41/9376	0.635230352303523	SSBP1/RPA3/ATM	-0.844532962991964
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1080	41/9376	0.635230352303523	GRIN2C/GABRA3/GRIA4	-0.844532962991964
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	9/1080	105/9376	0.744126984126984	UBA52/RPS27A/UBB/TOMM7/TAX1BP1/GABARAP/GABARAPL2/TOMM20/NRAS	-0.951303273672182
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/1080	85/9376	0.714945533769063	ENPP1/DCK/TYMS/DUT/CMPK2/ADA2/GUK1	-0.952509305055268
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1080	30/9376	0.578765432098765	PLA2G2A/PLAAT3	-0.833748156937625
Organismal Systems	Sensory system	hsa04742	Taste transduction	7/1080	86/9376	0.706632213608958	PLCB1/SCN9A/P2RY1/CHRM3/ADCY4/GABRA3/PLCB2	-0.986090867692403
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/1080	31/9376	0.560095579450418	PGLS/RPIA	-0.885141421116302
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/1080	18/9376	0.482304526748971	PRDX1	-0.793199156845542
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/1080	66/9376	0.657687991021324	MAF/IL12RB2/TLR2/TNF/TLR4	-1.00689087913692
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	6/1080	77/9376	0.676479076479076	CCND1/CDK6/CDC42/RB1/RAC1/RAC2	-1.02847267265397
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/1080	44/9376	0.591919191919192	HMGB1/PCNA/PARP1	-0.978922448842001
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/1080	32/9376	0.542592592592593	GABARAP/GABARAPL2	-0.935136291935249
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/1080	32/9376	0.542592592592593	PMAIP1/BIRC5	-0.935136291935249
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	7/1080	90/9376	0.67522633744856	CD28/CD4/TLR2/PTPN6/NRAS/EML4/TLR4	-1.11699405659928
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/1080	33/9376	0.526150392817059	IDH1/BCAT1	-0.983824117586759
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/1080	57/9376	0.609226770630279	ELOVL2/HACD4/HACD3/ACAA2	-1.06767904772659
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	12/1080	143/9376	0.728515928515929	C1QA/FCGR2A/C1QC/C1QB/FCGR3A/FCGR1A/CD86/CD28/C2/SSB/SNRPD3/TNF	-1.18033177577779
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	13/1080	154/9376	0.732852332852333	IDO2/IDO1/KYNU/ALAS2/QPRT/SHMT1/CMPK2/GGCX/AFMID/NADK2/FECH/BCAT1/PPCS	-1.20604172115432
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/1080	20/9376	0.434074074074074	NPL	-0.91409771978508
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/1080	34/9376	0.510675381263617	POLR2K/POLR2L	-1.03128746174195
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/1080	70/9376	0.62010582010582	CD36/SLC2A1/TNFRSF1B/ADIPOR1/TNF	-1.15104759092152
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/1080	70/9376	0.62010582010582	HPGDS/MGST2/SULT1A1/GSTP1/CBR1	-1.15104759092152
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/1080	93/9376	0.653444842692155	RBPJ/MAF/IL12RB2/CD4/DLL4/MAML3/JAG2	-1.21180519378673
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/1080	48/9376	0.542592592592593	HMGCLL1/ACAA2/BCAT1	-1.14628520665079
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	6/1080	83/9376	0.627576974564926	HMGCLL1/IDH1/PRDX1/SLC27A2/SOD1/PRDX5	-1.22959119825672
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1080	36/9376	0.482304526748971	KL/AKR1B1	-1.12283340330347
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/1080	36/9376	0.482304526748971	ENPP1/PYGL	-1.12283340330347
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/1080	36/9376	0.482304526748971	GALNT1/C1GALT1	-1.12283340330347
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	14/1080	169/9376	0.719175980714442	VAMP8/UBA52/RPS27A/UBB/TAX1BP1/GABARAP/CTSL/GABARAPL2/HMGB1/STX7/WDFY3/TANK/NRAS/CTSD	-1.32917350548074
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/1080	50/9376	0.520888888888889	GATM/LAP3/CNDP2	-1.2255659420542
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/1080	23/9376	0.377455716586151	FDPS	-1.07850420967923
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/1080	78/9376	0.55650522317189	PLCB1/INPP5D/PIK3CG/PIK3C2A/PLCB2	-1.4190711931582
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/1080	66/9376	0.526150392817059	HSD17B2/HSD17B1/CYP19A1/COMT	-1.39380107925118
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/1080	26/9376	0.333903133903134	SCARB1	-1.2271040886609
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1080	27/9376	0.321536351165981	HMGCLL1	-1.27376417526575
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/1080	83/9376	0.522980812137439	HDAC2/RNF2/MTF2/SKP1/AURKB	-1.5749257020566
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	8/1080	119/9376	0.583629007158419	TNFRSF1B/VCAM1/CASP10/RHBDF2/TNF/ICAM1/CREB3L1/RIPK3	-1.64923278355843
NA	NA	hsa04382	Cornified envelope formation	17/1080	217/9376	0.680116060761222	S100A9/S100A10/KRT18/KRT8/S100A11/DSP/KRT23/ITGA6/SPTLC2/KRT7/KRT1/KRT19/CLDN11/OCLN/SPTLC3/TJP1/S100A16	-1.72013058204538
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/1080	30/9376	0.289382716049383	IDH1	-1.40652238901904
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/1080	30/9376	0.289382716049383	PIGX	-1.40652238901904
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	27/1080	323/9376	0.725696594427245	MARCKS/CCND1/CDK6/ZEB2/FSCN1/EZR/STMN1/CCND2/WNT3A/IGF2BP1/HNRNPK/FGFR3/SOS1/EFNA5/PDCD4/PRKCB/HDAC2/NRAS/NOTCH4/ATM/CDC25B/CYP24A1/RDX/PAK4/GRB2/EFNA1/DNMT3A	-1.81008656442943
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	8/1080	122/9376	0.569277474195507	CD36/CCND1/IGF1/EIF4EBP1/ADIPOR1/PPARG/CREB3L1/CCNA2	-1.72773009009289
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/1080	47/9376	0.369424743892829	TNF/CACNA1D	-1.56362084553877
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1080	31/9376	0.280047789725209	KL	-1.44863177719903
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/1080	31/9376	0.280047789725209	CNDP2	-1.44863177719903
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/1080	75/9376	0.463012345679012	IDH1/SHMT1/RPIA/BCAT1	-1.68458626288884
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/1080	32/9376	0.271296296296296	AKR1B1	-1.48978190638267
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/1080	32/9376	0.271296296296296	ACSS1	-1.48978190638267
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/1080	63/9376	0.413403880070547	PRDM6/MECOM/BBOX1	-1.68549629999074
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/1080	65/9376	0.400683760683761	LIPG/AKR1B1/PLPP3	-1.74935401024125
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	7/1080	116/9376	0.523882503192848	IDH1/ACSS1/SHMT1/PGLS/GCSH/RPIA/GLDC	-1.86166179883247
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/1080	79/9376	0.439568682606657	HPGDS/MGST2/GSTP1/CBR1	-1.80479413283311
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/1080	35/9376	0.248042328042328	AKR1B1	-1.60802899357625
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/1080	94/9376	0.461780929866036	S100A9/CXCL8/MMP1/HSP90B1/TNF	-1.89219273458355
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/1080	37/9376	0.234634634634635	ASPA	-1.68299421839347
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/1080	37/9376	0.234634634634635	COMT	-1.68299421839347
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/1080	37/9376	0.234634634634635	UXS1	-1.68299421839347
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/1080	54/9376	0.321536351165981	DNMT3A/BCAT1	-1.80398141308286
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/1080	54/9376	0.321536351165981	RPA3/CENPX	-1.80398141308286
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/1080	73/9376	0.356773211567732	HPGDS/MGST2/GSTP1	-1.99056877386434
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/1080	103/9376	0.421431139877742	SAP18/PPP1CA/PABPC4L/ALYREF/MAGOH	-2.13023090936224
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/1080	43/9376	0.201894918173988	ACAA2	-1.89254761692638
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/1080	44/9376	0.197306397306397	GTF2H5	-1.92553722610506
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/1080	45/9376	0.192921810699588	ABCG2	-1.95803710469842
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/1080	47/9376	0.184712371946415	ACSS1	-2.02164724668135
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/1080	82/9376	0.317615176151761	MGST2/GSTP1/DUT	-2.23922686537525
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/1080	117/9376	0.296802785691675	ACTB/HDAC2/MTA1/EPC1	-2.76153896026365
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/1080	67/9376	0.129574350469873	ACSS1	-2.57976835241292
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/1080	109/9376	0.238939857288481	IL6ST/CD4/AHR	-2.883538736296
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/1080	183/9376	0.142319368548877	NOP10/SNU13/RAN	-4.22751991165295
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/1080	449/9376	0.135346036459622	CALM1/SLC8A1/CALM2/CALM3/ARRB2/GRK3/CALML4	-6.77447873665643