ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 80/1849 175/18639 0.457142857142857 4.60826701692034 1.3721658160815e-34 1.66169280327469e-31 GO:0015078 proton transmembrane transporter activity 57/1849 185/18639 0.308108108108108 3.1059096955257 2.18761692113491e-15 1.32460204574719e-12 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 30/1849 68/18639 0.441176470588235 4.44731651449114 2.61370204099645e-13 1.0550643905489e-10 GO:0022853 active monoatomic ion transmembrane transporter activity 40/1849 118/18639 0.338983050847458 3.41714715237737 1.05809910544337e-12 3.20339504172981e-10 GO:0009055 electron transfer activity 39/1849 116/18639 0.336206896551724 3.38916189552601 2.72032376529986e-12 6.58862415955626e-10 GO:0030695 GTPase regulator activity 94/1849 489/18639 0.192229038854806 1.93778099254447 2.17083133178425e-10 4.20611460862107e-08 GO:0060589 nucleoside-triphosphatase regulator activity 94/1849 490/18639 0.191836734693878 1.93382633745764 2.43128012059022e-10 4.20611460862107e-08 GO:0015399 primary active transmembrane transporter activity 42/1849 166/18639 0.253012048192771 2.55050922999733 8.611539291191e-09 1.23993031108353e-06 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 12/1849 18/18639 0.666666666666667 6.7203893996755 9.2150064407529e-09 1.23993031108353e-06 GO:0038024 cargo receptor activity 23/1849 65/18639 0.353846153846154 3.56697591213546 2.67555865585897e-08 3.24010153224521e-06 GO:0048027 mRNA 5'-UTR binding 13/1849 24/18639 0.541666666666667 5.46031638723634 7.55077056622331e-08 8.31271195972403e-06 GO:0008137 NADH dehydrogenase (ubiquinone) activity 17/1849 41/18639 0.414634146341463 4.17975438272501 1.20137608256927e-07 1.21238869665948e-05 GO:0098631 cell adhesion mediator activity 24/1849 76/18639 0.315789473684211 3.18334234721471 1.62109193075305e-07 1.46666798874839e-05 GO:0004129 cytochrome-c oxidase activity 10/1849 15/18639 0.666666666666667 6.7203893996755 1.69556992918889e-07 1.46666798874839e-05 GO:0004601 peroxidase activity 20/1849 57/18639 0.350877192982456 3.53704705246079 2.51601832969467e-07 2.03126546484016e-05 GO:0005178 integrin binding 38/1849 161/18639 0.236024844720497 2.37926829677952 3.03974662397429e-07 2.30070822602054e-05 GO:0031720 haptoglobin binding 8/1849 10/18639 0.8 8.0644672796106 3.46409257748441e-07 2.4676565360786e-05 GO:0003954 NADH dehydrogenase activity 17/1849 44/18639 0.386363636363636 3.89477112935739 4.06955685540114e-07 2.624275730324e-05 GO:0016675 oxidoreductase activity, acting on a heme group of donors 10/1849 16/18639 0.625 6.30036506219578 4.11736076599142e-07 2.624275730324e-05 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 20/1849 59/18639 0.338983050847458 3.41714715237737 4.78179425785252e-07 2.8953764231297e-05 GO:0016209 antioxidant activity 25/1849 86/18639 0.290697674418605 2.93040235450967 5.32346615686269e-07 3.06986548379082e-05 GO:0045296 cadherin binding 62/1849 334/18639 0.18562874251497 1.87124615020905 9.01261021908982e-07 4.96103226150808e-05 GO:0001540 amyloid-beta binding 24/1849 83/18639 0.289156626506024 2.91486769142552 9.93888028729756e-07 5.23303653387711e-05 GO:0005096 GTPase activator activity 52/1849 271/18639 0.191881918819188 1.9342818198328 2.45474606589706e-06 0.000123862395241722 GO:0005085 guanyl-nucleotide exchange factor activity 46/1849 230/18639 0.2 2.01611681990265 2.89050163147137e-06 0.000140015899028473 GO:0005044 scavenger receptor activity 12/1849 27/18639 0.444444444444444 4.48025959978367 3.67438583442574e-06 0.000164803009092207 GO:0015252 proton channel activity 12/1849 27/18639 0.444444444444444 4.48025959978367 3.67438583442574e-06 0.000164803009092207 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 18/1849 58/18639 0.310344827586207 3.1284571343317 7.39251743842972e-06 0.000314315196941089 GO:0035325 Toll-like receptor binding 8/1849 13/18639 0.615384615384615 6.20343636893123 7.52695351882047e-06 0.000314315196941089 GO:0038187 pattern recognition receptor activity 16/1849 48/18639 0.333333333333333 3.36019469983775 8.4809777992018e-06 0.000342348803827779 GO:0098632 cell-cell adhesion mediator activity 17/1849 55/18639 0.309090909090909 3.11581690348591 1.40049216101898e-05 0.000547095486127093 GO:0005344 oxygen carrier activity 8/1849 14/18639 0.571428571428571 5.76033377115043 1.60294696824977e-05 0.000583907713847117 GO:0015026 coreceptor activity 18/1849 61/18639 0.295081967213115 2.97459858674161 1.61384502238255e-05 0.000583907713847117 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 14/1849 40/18639 0.35 3.52820443482964 1.63937756158563e-05 0.000583907713847117 GO:0019838 growth factor binding 30/1849 136/18639 0.220588235294118 2.22365825724557 2.14184957973376e-05 0.000723928829511436 GO:1990948 ubiquitin ligase inhibitor activity 7/1849 11/18639 0.636363636363636 6.41491715423571 2.15205927848156e-05 0.000723928829511436 GO:0019955 cytokine binding 31/1849 144/18639 0.215277777777778 2.17012574364521 2.61435394249533e-05 0.000855670979557257 GO:0022804 active transmembrane transporter activity 73/1849 457/18639 0.159737417943107 1.61024647541459 2.87501948894377e-05 0.000916223316081818 GO:0031386 protein tag activity 8/1849 15/18639 0.533333333333333 5.3763115197404 3.135362874732e-05 0.000926079132024502 GO:0055105 ubiquitin-protein transferase inhibitor activity 8/1849 15/18639 0.533333333333333 5.3763115197404 3.135362874732e-05 0.000926079132024502 GO:0141047 molecular tag activity 8/1849 15/18639 0.533333333333333 5.3763115197404 3.135362874732e-05 0.000926079132024502 GO:0019843 rRNA binding 18/1849 65/18639 0.276923076923077 2.79154636601905 4.1660441092017e-05 0.00120120938481982 GO:0033218 amide binding 45/1849 247/18639 0.182186234817814 1.83654366185464 4.35020983588927e-05 0.00122514049099114 GO:0017124 SH3 domain binding 26/1849 115/18639 0.226086956521739 2.27908857902039 4.75197325812578e-05 0.00130787263990689 GO:0051015 actin filament binding 39/1849 209/18639 0.186602870813397 1.88106593244506 8.02140551529578e-05 0.00215864935089404 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 9/1849 21/18639 0.428571428571429 4.32025032836282 8.84825008095931e-05 0.00232939801044385 GO:0070700 BMP receptor binding 7/1849 13/18639 0.538461538461538 5.42800682281483 9.35029937276432e-05 0.00240919415753566 GO:0016651 oxidoreductase activity, acting on NAD(P)H 21/1849 88/18639 0.238636363636364 2.40559393283839 0.000109051183581184 0.00275127048576696 GO:0046875 ephrin receptor binding 10/1849 28/18639 0.357142857142857 3.60020860696902 0.000220838964300989 0.00545787726058158 GO:0019864 IgG binding 6/1849 11/18639 0.545454545454545 5.49850041791632 0.000281156404081168 0.00680960810684588 GO:0001618 virus receptor activity 19/1849 81/18639 0.234567901234568 2.36458145544138 0.000288899347508714 0.00682693205397039 GO:0004953 icosanoid receptor activity 7/1849 15/18639 0.466666666666667 4.70427257977285 0.000293146545670075 0.00682693205397039 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 9/1849 24/18639 0.375 3.78021903731747 0.000298861341451009 0.00682869970749381 GO:0140272 exogenous protein binding 19/1849 82/18639 0.231707317073171 2.33574509622868 0.000341572657173153 0.00766008310808682 GO:0004857 enzyme inhibitor activity 63/1849 416/18639 0.151442307692308 1.52662691891667 0.000442657645241065 0.009746516516126 GO:0005504 fatty acid binding 13/1849 47/18639 0.276595744680851 2.78824666582281 0.000481015697032679 0.0104019644483317 GO:0005201 extracellular matrix structural constituent 31/1849 168/18639 0.18452380952381 1.86010778026733 0.000503982782403309 0.0107074236752703 GO:0030169 low-density lipoprotein particle binding 7/1849 17/18639 0.411764705882353 4.1508287468584 0.000741153050599033 0.0154110592154831 GO:0019207 kinase regulator activity 46/1849 287/18639 0.160278745644599 1.61570337483488 0.000750827823049961 0.0154110592154831 GO:0016504 peptidase activator activity 14/1849 57/18639 0.245614035087719 2.47593293672255 0.00108606726197086 0.0218498307540087 GO:0030228 lipoprotein particle receptor activity 7/1849 18/18639 0.388888888888889 3.92022714981071 0.00110953150689994 0.0218498307540087 GO:0005021 vascular endothelial growth factor receptor activity 13/1849 51/18639 0.254901960784314 2.5695606528171 0.00111865359764536 0.0218498307540087 GO:0097110 scaffold protein binding 16/1849 70/18639 0.228571428571429 2.30413350846017 0.00114153926584387 0.0219429214434434 GO:0019887 protein kinase regulator activity 41/1849 255/18639 0.16078431372549 1.62079979639233 0.00132602399445616 0.0250908602701002 GO:0003779 actin binding 64/1849 443/18639 0.144469525959368 1.45633720625022 0.00137939622450154 0.0256992127364826 GO:0019763 immunoglobulin receptor activity 6/1849 14/18639 0.428571428571429 4.32025032836282 0.00140560308835713 0.0257238402042234 GO:0140375 immune receptor activity 28/1849 156/18639 0.179487179487179 1.80933560760494 0.00142320172888767 0.0257238402042234 GO:0042277 peptide binding 40/1849 249/18639 0.160642570281124 1.61937093968084 0.00153245579186006 0.0272912347638607 GO:0045309 protein phosphorylated amino acid binding 14/1849 59/18639 0.23728813559322 2.39200300666416 0.00155500363542089 0.0272914406158652 GO:0030506 ankyrin binding 7/1849 19/18639 0.368421052631579 3.71389940508383 0.00160743887908238 0.0278086926081252 GO:0038064 collagen receptor activity 13/1849 53/18639 0.245283018867925 2.47259609988061 0.00163872473838431 0.0279506430730057 GO:0033612 receptor serine/threonine kinase binding 9/1849 30/18639 0.3 3.02417522985398 0.0018912665150167 0.0318100520789614 GO:0016500 protein-hormone receptor activity 15/1849 67/18639 0.223880597014925 2.25684718645819 0.00200510518525602 0.033262772319795 GO:0005041 low-density lipoprotein particle receptor activity 6/1849 15/18639 0.4 4.0322336398053 0.00214724078348184 0.0351393052540068 GO:0005004 GPI-linked ephrin receptor activity 12/1849 49/18639 0.244897959183673 2.46871447335018 0.00247825361153554 0.0357281562329706 GO:0005008 hepatocyte growth factor receptor activity 12/1849 49/18639 0.244897959183673 2.46871447335018 0.00247825361153554 0.0357281562329706 GO:0005009 insulin receptor activity 12/1849 49/18639 0.244897959183673 2.46871447335018 0.00247825361153554 0.0357281562329706 GO:0005011 macrophage colony-stimulating factor receptor activity 12/1849 49/18639 0.244897959183673 2.46871447335018 0.00247825361153554 0.0357281562329706 GO:0005018 platelet-derived growth factor alpha-receptor activity 12/1849 49/18639 0.244897959183673 2.46871447335018 0.00247825361153554 0.0357281562329706 GO:0005020 stem cell factor receptor activity 12/1849 49/18639 0.244897959183673 2.46871447335018 0.00247825361153554 0.0357281562329706 GO:0008288 boss receptor activity 12/1849 49/18639 0.244897959183673 2.46871447335018 0.00247825361153554 0.0357281562329706 GO:0036332 placental growth factor receptor activity 12/1849 49/18639 0.244897959183673 2.46871447335018 0.00247825361153554 0.0357281562329706 GO:0038062 protein tyrosine kinase collagen receptor activity 12/1849 49/18639 0.244897959183673 2.46871447335018 0.00247825361153554 0.0357281562329706 GO:0060175 brain-derived neurotrophic factor receptor activity 12/1849 49/18639 0.244897959183673 2.46871447335018 0.00247825361153554 0.0357281562329706 GO:0004954 prostanoid receptor activity 5/1849 11/18639 0.454545454545455 4.58208368159693 0.0026444899684029 0.0372381087411152 GO:0010854 adenylate cyclase regulator activity 5/1849 11/18639 0.454545454545455 4.58208368159693 0.0026444899684029 0.0372381087411152 GO:0061134 peptidase regulator activity 36/1849 226/18639 0.15929203539823 1.6057567592145 0.00295376797271133 0.0395474363410944 GO:0005006 epidermal growth factor receptor activity 12/1849 50/18639 0.24 2.41934018388318 0.00297177267303022 0.0395474363410944 GO:0005007 fibroblast growth factor receptor activity 12/1849 50/18639 0.24 2.41934018388318 0.00297177267303022 0.0395474363410944 GO:0005017 platelet-derived growth factor receptor activity 12/1849 50/18639 0.24 2.41934018388318 0.00297177267303022 0.0395474363410944 GO:0005019 platelet-derived growth factor beta-receptor activity 12/1849 50/18639 0.24 2.41934018388318 0.00297177267303022 0.0395474363410944 GO:0031406 carboxylic acid binding 31/1849 187/18639 0.165775401069519 1.67111287211182 0.00300992355404869 0.0396197546081844 GO:0070411 I-SMAD binding 6/1849 16/18639 0.375 3.78021903731747 0.00314961048079881 0.0408402010715456 GO:0005109 frizzled binding 10/1849 38/18639 0.263157894736842 2.65278528934559 0.00317008992628017 0.0408402010715456 GO:0005010 insulin-like growth factor receptor activity 12/1849 51/18639 0.235294117647059 2.37190214106194 0.00354196315776401 0.0443135244126698 GO:0005030 neurotrophin receptor activity 12/1849 51/18639 0.235294117647059 2.37190214106194 0.00354196315776401 0.0443135244126698 GO:0043177 organic acid binding 31/1849 189/18639 0.164021164021164 1.6534291380154 0.00354947305369857 0.0443135244126698 GO:0031625 ubiquitin protein ligase binding 45/1849 302/18639 0.149006622516556 1.50207378966257 0.00369556725585366 0.045666652518763 GO:0031683 G-protein beta/gamma-subunit complex binding 7/1849 22/18639 0.318181818181818 3.20745857711785 0.00417201850978773 0.0501519434363292 GO:0140517 protein-RNA adaptor activity 7/1849 22/18639 0.318181818181818 3.20745857711785 0.00417201850978773 0.0501519434363292 GO:0051219 phosphoprotein binding 18/1849 93/18639 0.193548387096774 1.95108079345418 0.00418277975810838 0.0501519434363292 GO:0015036 disulfide oxidoreductase activity 10/1849 40/18639 0.25 2.52014602487831 0.00473507995078212 0.0561798018339402 GO:0015035 protein-disulfide reductase activity 9/1849 34/18639 0.264705882352941 2.66838990869468 0.00482468983544986 0.0561798018339402 GO:0019825 oxygen binding 9/1849 34/18639 0.264705882352941 2.66838990869468 0.00482468983544986 0.0561798018339402 GO:0005003 ephrin receptor activity 12/1849 53/18639 0.226415094339623 2.28239639988979 0.00494590485381465 0.0565046299808447 GO:0005005 transmembrane-ephrin receptor activity 12/1849 53/18639 0.226415094339623 2.28239639988979 0.00494590485381465 0.0565046299808447 GO:0004714 transmembrane receptor protein tyrosine kinase activity 13/1849 60/18639 0.216666666666667 2.18412655489454 0.00523761905773471 0.0592780998029601 GO:0001784 phosphotyrosine residue binding 11/1849 47/18639 0.234042553191489 2.35928564031161 0.00536483809679427 0.0600596912293198 GO:0050840 extracellular matrix binding 14/1849 67/18639 0.208955223880597 2.10639070736098 0.00540586816184629 0.0600596912293198 GO:0005543 phospholipid binding 67/1849 497/18639 0.134808853118712 1.35895198122211 0.00588728832018954 0.064481803420903 GO:0004896 cytokine receptor activity 18/1849 96/18639 0.1875 1.89010951865873 0.0059103882574073 0.064481803420903 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 5/1849 13/18639 0.384615384615385 3.87714773058202 0.00622110582484916 0.0672657067311816 GO:0030165 PDZ domain binding 16/1849 83/18639 0.192771084337349 1.94324512761701 0.00696873681628187 0.0746826573851093 GO:0044389 ubiquitin-like protein ligase binding 46/1849 322/18639 0.142857142857143 1.44008344278761 0.00738559767489663 0.0783470512992465 GO:0001664 G protein-coupled receptor binding 43/1849 297/18639 0.144781144781145 1.45947850599013 0.00744005854617122 0.0783470512992465 GO:0044325 transmembrane transporter binding 23/1849 136/18639 0.169117647058824 1.70480466388827 0.00761291087855944 0.0794761644304783 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 49/1849 349/18639 0.140401146131805 1.41532556124971 0.00808480067722333 0.0836811420522859 GO:0008301 DNA binding, bending 6/1849 19/18639 0.315789473684211 3.18334234721471 0.00823225243219659 0.0844852347066955 GO:0043394 proteoglycan binding 9/1849 37/18639 0.243243243243243 2.45203397015187 0.00873029823702636 0.088778822427832 GO:0032036 myosin heavy chain binding 5/1849 14/18639 0.357142857142857 3.60020860696902 0.00889638512290031 0.088778822427832 GO:0019199 transmembrane receptor protein kinase activity 15/1849 78/18639 0.192307692307692 1.93857386529101 0.00901335100863092 0.088778822427832 GO:0035401 histone H3Y41 kinase activity 20/1849 115/18639 0.173913043478261 1.75314506078491 0.00906101257238661 0.088778822427832 GO:0140801 histone H2AXY142 kinase activity 20/1849 115/18639 0.173913043478261 1.75314506078491 0.00906101257238661 0.088778822427832 GO:0017147 Wnt-protein binding 8/1849 31/18639 0.258064516129032 2.6014410579389 0.00909048223043036 0.088778822427832 GO:0033293 monocarboxylic acid binding 15/1849 79/18639 0.189873417721519 1.91403495560378 0.0101329109884973 0.0981676416565616 GO:0016505 peptidase activator activity involved in apoptotic process 6/1849 20/18639 0.3 3.02417522985398 0.0107904348086105 0.103708067882757 GO:0008081 phosphoric diester hydrolase activity 16/1849 87/18639 0.183908045977011 1.85390052404841 0.0109655002677878 0.104107771167519 GO:0071813 lipoprotein particle binding 8/1849 32/18639 0.25 2.52014602487831 0.0110899277296531 0.104107771167519 GO:0071814 protein-lipid complex binding 8/1849 32/18639 0.25 2.52014602487831 0.0110899277296531 0.104107771167519 GO:0048306 calcium-dependent protein binding 15/1849 80/18639 0.1875 1.89010951865873 0.0113591502604107 0.105814853579672 GO:0030246 carbohydrate binding 40/1849 280/18639 0.142857142857143 1.44008344278761 0.0118518531282382 0.108001809065528 GO:0005523 tropomyosin binding 5/1849 15/18639 0.333333333333333 3.36019469983775 0.0122709572926095 0.108001809065528 GO:0015929 hexosaminidase activity 5/1849 15/18639 0.333333333333333 3.36019469983775 0.0122709572926095 0.108001809065528 GO:0004955 prostaglandin receptor activity 4/1849 10/18639 0.4 4.0322336398053 0.0124168946354578 0.108001809065528 GO:0005031 tumor necrosis factor receptor activity 4/1849 10/18639 0.4 4.0322336398053 0.0124168946354578 0.108001809065528 GO:0005381 iron ion transmembrane transporter activity 4/1849 10/18639 0.4 4.0322336398053 0.0124168946354578 0.108001809065528 GO:0008190 eukaryotic initiation factor 4E binding 4/1849 10/18639 0.4 4.0322336398053 0.0124168946354578 0.108001809065528 GO:0008239 dipeptidyl-peptidase activity 4/1849 10/18639 0.4 4.0322336398053 0.0124168946354578 0.108001809065528 GO:1905394 retromer complex binding 4/1849 10/18639 0.4 4.0322336398053 0.0124168946354578 0.108001809065528 GO:0140297 DNA-binding transcription factor binding 64/1849 488/18639 0.131147540983607 1.32204381632961 0.0124857582734715 0.108001809065528 GO:0020037 heme binding 23/1849 142/18639 0.161971830985915 1.63277066400567 0.012646692512375 0.108618047038909 GO:0019956 chemokine binding 8/1849 33/18639 0.242424242424242 2.44377796351836 0.0133959985711192 0.113444435451925 GO:0140311 protein sequestering activity 8/1849 33/18639 0.242424242424242 2.44377796351836 0.0133959985711192 0.113444435451925 GO:0001846 opsonin binding 6/1849 21/18639 0.285714285714286 2.88016688557521 0.0138637160479696 0.116590000931189 GO:0002020 protease binding 22/1849 136/18639 0.161764705882353 1.63068272198008 0.0147093823109726 0.122848703300606 GO:0019210 kinase inhibitor activity 16/1849 90/18639 0.177777777777778 1.79210383991347 0.0150053499281889 0.124462183308471 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 11/1849 54/18639 0.203703703703704 2.05345231656751 0.0155413809715045 0.128031376574775 GO:0005324 long-chain fatty acid transmembrane transporter activity 5/1849 16/18639 0.3125 3.15018253109789 0.0164170240252508 0.132540107297191 GO:0017070 U6 snRNA binding 5/1849 16/18639 0.3125 3.15018253109789 0.0164170240252508 0.132540107297191 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 5/1849 16/18639 0.3125 3.15018253109789 0.0164170240252508 0.132540107297191 GO:0001530 lipopolysaccharide binding 9/1849 41/18639 0.219512195121951 2.21281114379559 0.0171728260506258 0.137598716094922 GO:0004860 protein kinase inhibitor activity 15/1849 84/18639 0.178571428571429 1.80010430348451 0.0174628801268801 0.137598716094922 GO:0033691 sialic acid binding 6/1849 22/18639 0.272727272727273 2.74925020895816 0.0174981026247878 0.137598716094922 GO:0061133 endopeptidase activator activity 6/1849 22/18639 0.272727272727273 2.74925020895816 0.0174981026247878 0.137598716094922 GO:0001851 complement component C3b binding 4/1849 11/18639 0.363636363636364 3.66566694527755 0.0180011258737749 0.137970654640136 GO:0034713 type I transforming growth factor beta receptor binding 4/1849 11/18639 0.363636363636364 3.66566694527755 0.0180011258737749 0.137970654640136 GO:0050786 RAGE receptor binding 4/1849 11/18639 0.363636363636364 3.66566694527755 0.0180011258737749 0.137970654640136 GO:0099528 G protein-coupled neurotransmitter receptor activity 4/1849 11/18639 0.363636363636364 3.66566694527755 0.0180011258737749 0.137970654640136 GO:0003785 actin monomer binding 7/1849 29/18639 0.241379310344828 2.43324443781354 0.0206784353029969 0.157494246238549 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 5/1849 17/18639 0.294117647058824 2.96487767632743 0.021397736313424 0.158004016314369 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 5/1849 17/18639 0.294117647058824 2.96487767632743 0.021397736313424 0.158004016314369 GO:0016805 dipeptidase activity 5/1849 17/18639 0.294117647058824 2.96487767632743 0.021397736313424 0.158004016314369 GO:0019198 transmembrane receptor protein phosphatase activity 5/1849 17/18639 0.294117647058824 2.96487767632743 0.021397736313424 0.158004016314369 GO:0036041 long-chain fatty acid binding 5/1849 17/18639 0.294117647058824 2.96487767632743 0.021397736313424 0.158004016314369 GO:0004602 glutathione peroxidase activity 6/1849 23/18639 0.260869565217391 2.62971759117737 0.0217358183421431 0.158566722965875 GO:0016849 phosphorus-oxygen lyase activity 6/1849 23/18639 0.260869565217391 2.62971759117737 0.0217358183421431 0.158566722965875 GO:0055106 ubiquitin-protein transferase regulator activity 8/1849 36/18639 0.222222222222222 2.24012979989183 0.0223961812760402 0.162405841468771 GO:0046332 SMAD binding 14/1849 79/18639 0.177215189873418 1.7864326252302 0.0225356362673598 0.162444378093885 GO:0008200 ion channel inhibitor activity 9/1849 43/18639 0.209302325581395 2.10988969524696 0.0231216958962223 0.165682684794824 GO:0005539 glycosaminoglycan binding 34/1849 242/18639 0.140495867768595 1.41628041067542 0.0239108970899404 0.170329978681869 GO:0004875 complement receptor activity 4/1849 12/18639 0.333333333333333 3.36019469983775 0.02491894905393 0.173430156921318 GO:0010853 cyclase activator activity 4/1849 12/18639 0.333333333333333 3.36019469983775 0.02491894905393 0.173430156921318 GO:0070008 serine-type exopeptidase activity 4/1849 12/18639 0.333333333333333 3.36019469983775 0.02491894905393 0.173430156921318 GO:0097677 STAT family protein binding 4/1849 12/18639 0.333333333333333 3.36019469983775 0.02491894905393 0.173430156921318 GO:0043539 protein serine/threonine kinase activator activity 13/1849 73/18639 0.178082191780822 1.79517251087222 0.0263102121947705 0.182055982302927 GO:0016248 channel inhibitor activity 9/1849 44/18639 0.204545454545455 2.06193765671862 0.0265906207264902 0.182055982302927 GO:0046906 tetrapyrrole binding 23/1849 152/18639 0.151315789473684 1.52535154137372 0.0266093384538547 0.182055982302927 GO:0005200 structural constituent of cytoskeleton 18/1849 112/18639 0.160714285714286 1.62009387313606 0.0271309097261195 0.183439704506588 GO:0031690 adrenergic receptor binding 5/1849 18/18639 0.277777777777778 2.80016224986479 0.0272660171851245 0.183439704506588 GO:0098641 cadherin binding involved in cell-cell adhesion 5/1849 18/18639 0.277777777777778 2.80016224986479 0.0272660171851245 0.183439704506588 GO:0004879 nuclear receptor activity 11/1849 59/18639 0.186440677966102 1.87943093380755 0.0288595768805643 0.19308810830035 GO:0043531 ADP binding 8/1849 38/18639 0.210526315789474 2.12222823147647 0.0303554666904514 0.201243610634861 GO:0141110 transporter inhibitor activity 9/1849 45/18639 0.2 2.01611681990265 0.0304108841834679 0.201243610634861 GO:0001848 complement binding 6/1849 25/18639 0.24 2.41934018388318 0.0321671324790498 0.211323972199868 GO:0098531 ligand-modulated transcription factor activity 11/1849 60/18639 0.183333333333333 1.84810708491076 0.0322831832014663 0.211323972199868 GO:0005035 death receptor activity 4/1849 13/18639 0.307692307692308 3.10171818446562 0.0332291016001881 0.214044904456531 GO:0035673 oligopeptide transmembrane transporter activity 4/1849 13/18639 0.307692307692308 3.10171818446562 0.0332291016001881 0.214044904456531 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 4/1849 13/18639 0.307692307692308 3.10171818446562 0.0332291016001881 0.214044904456531 GO:0030295 protein kinase activator activity 21/1849 139/18639 0.151079136690647 1.52296594309193 0.0334939216085995 0.214609201418063 GO:0015245 fatty acid transmembrane transporter activity 5/1849 19/18639 0.263157894736842 2.65278528934559 0.0340637903111702 0.217111842456985 GO:0043425 bHLH transcription factor binding 7/1849 32/18639 0.21875 2.20512777176852 0.0343847486564497 0.218010107973616 GO:0019209 kinase activator activity 22/1849 148/18639 0.148648648648649 1.4984652039817 0.0353085026240631 0.222701024363231 GO:0004713 protein tyrosine kinase activity 21/1849 140/18639 0.15 1.51208761492699 0.035859423271879 0.225003946021997 GO:0005496 steroid binding 17/1849 108/18639 0.157407407407407 1.58675860825672 0.0371184406552152 0.231703255842606 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 10/1849 54/18639 0.185185185185185 1.86677483324319 0.03772491849705 0.234281416922706 GO:0008198 ferrous iron binding 6/1849 26/18639 0.230769230769231 2.32628863834921 0.0384205905617652 0.236179366346688 GO:0019865 immunoglobulin binding 6/1849 26/18639 0.230769230769231 2.32628863834921 0.0384205905617652 0.236179366346688 GO:0016829 lyase activity 28/1849 200/18639 0.14 1.41128177393186 0.0390498843154632 0.238835403565787 GO:1990782 protein tyrosine kinase binding 18/1849 117/18639 0.153846153846154 1.55085909223281 0.0398203709166986 0.242323965729256 GO:0010851 cyclase regulator activity 5/1849 20/18639 0.25 2.52014602487831 0.04182157547869 0.253229639523468 GO:0140313 molecular sequestering activity 10/1849 55/18639 0.181818181818182 1.83283347263877 0.0421667983810997 0.254049715619461 GO:0008238 exopeptidase activity 16/1849 102/18639 0.156862745098039 1.58126809404129 0.043406544956066 0.258982566329836 GO:0042562 hormone binding 15/1849 94/18639 0.159574468085106 1.60860384566701 0.0434132625639609 0.258982566329836 GO:0005507 copper ion binding 11/1849 63/18639 0.174603174603175 1.7601019856293 0.0442610787503615 0.262745913562195 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 8/1849 41/18639 0.195121951219512 1.96694323892941 0.0456130077393689 0.268142487244543 GO:0042169 SH2 domain binding 8/1849 41/18639 0.195121951219512 1.96694323892941 0.0456130077393689 0.268142487244543 GO:0005518 collagen binding 12/1849 72/18639 0.166666666666667 1.68009734991888 0.0500433544145435 0.292765711091847 GO:0009975 cyclase activity 5/1849 21/18639 0.238095238095238 2.40013907131268 0.0505584065507903 0.294356876600995 GO:0035591 signaling adaptor activity 19/1849 129/18639 0.147286821705426 1.48473719295156 0.0517371419567886 0.299778367988857 GO:0045499 chemorepellent activity 6/1849 28/18639 0.214285714285714 2.16012516418141 0.0531097476491552 0.306266211443462 GO:0031005 filamin binding 4/1849 15/18639 0.266666666666667 2.6881557598702 0.0541226357905556 0.309162792180957 GO:0050700 CARD domain binding 4/1849 15/18639 0.266666666666667 2.6881557598702 0.0541226357905556 0.309162792180957 GO:0008013 beta-catenin binding 16/1849 106/18639 0.150943396226415 1.52159759992653 0.0583232989857707 0.331593967473091 GO:0008093 cytoskeletal anchor activity 5/1849 22/18639 0.227272727272727 2.29104184079847 0.0602820253525556 0.339542012567185 GO:0030021 extracellular matrix structural constituent conferring compression resistance 5/1849 22/18639 0.227272727272727 2.29104184079847 0.0602820253525556 0.339542012567185 GO:0004629 phospholipase C activity 6/1849 29/18639 0.206896551724138 2.08563808955447 0.061570090000327 0.343600824840534 GO:0043236 laminin binding 6/1849 29/18639 0.206896551724138 2.08563808955447 0.061570090000327 0.343600824840534 GO:0061135 endopeptidase regulator activity 25/1849 184/18639 0.135869565217391 1.36964457873821 0.0654263103326275 0.362416189186812 GO:0005159 insulin-like growth factor receptor binding 4/1849 16/18639 0.25 2.52014602487831 0.0666911730456572 0.362416189186812 GO:0043023 ribosomal large subunit binding 4/1849 16/18639 0.25 2.52014602487831 0.0666911730456572 0.362416189186812 GO:0005080 protein kinase C binding 9/1849 52/18639 0.173076923076923 1.74471647876191 0.068066279570751 0.362416189186812 GO:0030159 signaling receptor complex adaptor activity 9/1849 52/18639 0.173076923076923 1.74471647876191 0.068066279570751 0.362416189186812 GO:0015203 polyamine transmembrane transporter activity 3/1849 10/18639 0.3 3.02417522985398 0.0687704394559395 0.362416189186812 GO:0016175 superoxide-generating NAD(P)H oxidase activity 3/1849 10/18639 0.3 3.02417522985398 0.0687704394559395 0.362416189186812 GO:0016303 1-phosphatidylinositol-3-kinase activity 3/1849 10/18639 0.3 3.02417522985398 0.0687704394559395 0.362416189186812 GO:0031434 mitogen-activated protein kinase kinase binding 3/1849 10/18639 0.3 3.02417522985398 0.0687704394559395 0.362416189186812 GO:0031996 thioesterase binding 3/1849 10/18639 0.3 3.02417522985398 0.0687704394559395 0.362416189186812 GO:0050815 phosphoserine residue binding 3/1849 10/18639 0.3 3.02417522985398 0.0687704394559395 0.362416189186812 GO:0071723 lipopeptide binding 3/1849 10/18639 0.3 3.02417522985398 0.0687704394559395 0.362416189186812 GO:1901981 phosphatidylinositol phosphate binding 25/1849 185/18639 0.135135135135135 1.36224109452882 0.0688321416292046 0.362416189186812 GO:0051087 protein-folding chaperone binding 19/1849 134/18639 0.141791044776119 1.42933655142352 0.0706459323910445 0.365821482761952 GO:0001968 fibronectin binding 6/1849 30/18639 0.2 2.01611681990265 0.0707806001334562 0.365821482761952 GO:0017134 fibroblast growth factor binding 5/1849 23/18639 0.217391304347826 2.19143132598114 0.0709893050776703 0.365821482761952 GO:0031681 G-protein beta-subunit binding 5/1849 23/18639 0.217391304347826 2.19143132598114 0.0709893050776703 0.365821482761952 GO:0140103 catalytic activity, acting on a glycoprotein 5/1849 23/18639 0.217391304347826 2.19143132598114 0.0709893050776703 0.365821482761952 GO:0046915 transition metal ion transmembrane transporter activity 8/1849 45/18639 0.177777777777778 1.79210383991347 0.0726941795153121 0.373019709292555 GO:0017046 peptide hormone binding 9/1849 53/18639 0.169811320754717 1.71179729991734 0.07511275257543 0.383803980459265 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 4/1849 17/18639 0.235294117647059 2.37190214106194 0.0806276151171135 0.398842891582174 GO:0008429 phosphatidylethanolamine binding 4/1849 17/18639 0.235294117647059 2.37190214106194 0.0806276151171135 0.398842891582174 GO:0015278 intracellularly gated calcium channel activity 4/1849 17/18639 0.235294117647059 2.37190214106194 0.0806276151171135 0.398842891582174 GO:0016018 cyclosporin A binding 4/1849 17/18639 0.235294117647059 2.37190214106194 0.0806276151171135 0.398842891582174 GO:0003925 G protein activity 9/1849 54/18639 0.166666666666667 1.68009734991888 0.0825903193911061 0.398842891582174 GO:0017069 snRNA binding 9/1849 54/18639 0.166666666666667 1.68009734991888 0.0825903193911061 0.398842891582174 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 5/1849 24/18639 0.208333333333333 2.10012168739859 0.0826668586186009 0.398842891582174 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 5/1849 24/18639 0.208333333333333 2.10012168739859 0.0826668586186009 0.398842891582174 GO:0005540 hyaluronic acid binding 5/1849 24/18639 0.208333333333333 2.10012168739859 0.0826668586186009 0.398842891582174 GO:0042625 ATPase-coupled ion transmembrane transporter activity 5/1849 24/18639 0.208333333333333 2.10012168739859 0.0826668586186009 0.398842891582174 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 5/1849 24/18639 0.208333333333333 2.10012168739859 0.0826668586186009 0.398842891582174 GO:0046961 proton-transporting ATPase activity, rotational mechanism 5/1849 24/18639 0.208333333333333 2.10012168739859 0.0826668586186009 0.398842891582174 GO:0050431 transforming growth factor beta binding 5/1849 24/18639 0.208333333333333 2.10012168739859 0.0826668586186009 0.398842891582174 GO:0070840 dynein complex binding 5/1849 24/18639 0.208333333333333 2.10012168739859 0.0826668586186009 0.398842891582174 GO:0005516 calmodulin binding 27/1849 207/18639 0.130434782608696 1.31485879558868 0.0852138185200834 0.407419987400931 GO:0005125 cytokine activity 30/1849 234/18639 0.128205128205128 1.29238257686067 0.0866572196050368 0.407419987400931 GO:0008046 axon guidance receptor activity 3/1849 11/18639 0.272727272727273 2.74925020895816 0.0878089320492511 0.407419987400931 GO:0008271 secondary active sulfate transmembrane transporter activity 3/1849 11/18639 0.272727272727273 2.74925020895816 0.0878089320492511 0.407419987400931 GO:0015217 ADP transmembrane transporter activity 3/1849 11/18639 0.272727272727273 2.74925020895816 0.0878089320492511 0.407419987400931 GO:0034056 estrogen response element binding 3/1849 11/18639 0.272727272727273 2.74925020895816 0.0878089320492511 0.407419987400931 GO:0045294 alpha-catenin binding 3/1849 11/18639 0.272727272727273 2.74925020895816 0.0878089320492511 0.407419987400931 GO:0048185 activin binding 3/1849 11/18639 0.272727272727273 2.74925020895816 0.0878089320492511 0.407419987400931 GO:0050998 nitric-oxide synthase binding 3/1849 11/18639 0.272727272727273 2.74925020895816 0.0878089320492511 0.407419987400931 GO:0140031 phosphorylation-dependent protein binding 3/1849 11/18639 0.272727272727273 2.74925020895816 0.0878089320492511 0.407419987400931 GO:0022884 macromolecule transmembrane transporter activity 6/1849 32/18639 0.1875 1.89010951865873 0.0914356211858587 0.422544534457566 GO:0016798 hydrolase activity, acting on glycosyl bonds 18/1849 130/18639 0.138461538461538 1.39577318300953 0.0917664843619653 0.422544534457566 GO:0004197 cysteine-type endopeptidase activity 13/1849 88/18639 0.147727272727273 1.489177196519 0.0936077764997253 0.429390217201392 GO:0003707 nuclear steroid receptor activity 5/1849 25/18639 0.2 2.01611681990265 0.0952917901534887 0.433220726833182 GO:0005537 D-mannose binding 5/1849 25/18639 0.2 2.01611681990265 0.0952917901534887 0.433220726833182 GO:0003746 translation elongation factor activity 4/1849 18/18639 0.222222222222222 2.24012979989183 0.0958737859548247 0.433220726833182 GO:0035615 clathrin adaptor activity 4/1849 18/18639 0.222222222222222 2.24012979989183 0.0958737859548247 0.433220726833182 GO:0030296 protein tyrosine kinase activator activity 6/1849 33/18639 0.181818181818182 1.83283347263877 0.102857855674468 0.460825945541335 GO:0140416 transcription regulator inhibitor activity 6/1849 33/18639 0.181818181818182 1.83283347263877 0.102857855674468 0.460825945541335 GO:0035091 phosphatidylinositol binding 35/1849 284/18639 0.123239436619718 1.2423255052217 0.105180067964162 0.460825945541335 GO:0005095 GTPase inhibitor activity 3/1849 12/18639 0.25 2.52014602487831 0.108772259714358 0.460825945541335 GO:0005165 neurotrophin receptor binding 3/1849 12/18639 0.25 2.52014602487831 0.108772259714358 0.460825945541335 GO:0008179 adenylate cyclase binding 3/1849 12/18639 0.25 2.52014602487831 0.108772259714358 0.460825945541335 GO:0008504 monoamine transmembrane transporter activity 3/1849 12/18639 0.25 2.52014602487831 0.108772259714358 0.460825945541335 GO:0016208 AMP binding 3/1849 12/18639 0.25 2.52014602487831 0.108772259714358 0.460825945541335 GO:0097371 MDM2/MDM4 family protein binding 3/1849 12/18639 0.25 2.52014602487831 0.108772259714358 0.460825945541335 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 3/1849 12/18639 0.25 2.52014602487831 0.108772259714358 0.460825945541335 GO:1990247 N6-methyladenosine-containing RNA reader activity 3/1849 12/18639 0.25 2.52014602487831 0.108772259714358 0.460825945541335 GO:0001637 G protein-coupled chemoattractant receptor activity 5/1849 26/18639 0.192307692307692 1.93857386529101 0.108832551961042 0.460825945541335 GO:0004112 cyclic-nucleotide phosphodiesterase activity 5/1849 26/18639 0.192307692307692 1.93857386529101 0.108832551961042 0.460825945541335 GO:0004950 chemokine receptor activity 5/1849 26/18639 0.192307692307692 1.93857386529101 0.108832551961042 0.460825945541335 GO:0005160 transforming growth factor beta receptor binding 5/1849 26/18639 0.192307692307692 1.93857386529101 0.108832551961042 0.460825945541335 GO:0030507 spectrin binding 5/1849 26/18639 0.192307692307692 1.93857386529101 0.108832551961042 0.460825945541335 GO:0050681 nuclear androgen receptor binding 5/1849 26/18639 0.192307692307692 1.93857386529101 0.108832551961042 0.460825945541335 GO:0097602 cullin family protein binding 5/1849 26/18639 0.192307692307692 1.93857386529101 0.108832551961042 0.460825945541335 GO:0003756 protein disulfide isomerase activity 4/1849 19/18639 0.210526315789474 2.12222823147647 0.112356451459799 0.466919219080052 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 4/1849 19/18639 0.210526315789474 2.12222823147647 0.112356451459799 0.466919219080052 GO:0034987 immunoglobulin receptor binding 4/1849 19/18639 0.210526315789474 2.12222823147647 0.112356451459799 0.466919219080052 GO:0043395 heparan sulfate proteoglycan binding 4/1849 19/18639 0.210526315789474 2.12222823147647 0.112356451459799 0.466919219080052 GO:0050145 nucleoside monophosphate kinase activity 4/1849 19/18639 0.210526315789474 2.12222823147647 0.112356451459799 0.466919219080052 GO:0048029 monosaccharide binding 11/1849 74/18639 0.148648648648649 1.4984652039817 0.112617016862211 0.466919219080052 GO:0030414 peptidase inhibitor activity 22/1849 169/18639 0.130177514792899 1.31226538573545 0.112970545987164 0.466919219080052 GO:0072341 modified amino acid binding 13/1849 91/18639 0.142857142857143 1.44008344278761 0.114161614679574 0.470237127132531 GO:0019208 phosphatase regulator activity 16/1849 117/18639 0.136752136752137 1.37854141531805 0.116193572587256 0.476984462383615 GO:0048487 beta-tubulin binding 7/1849 42/18639 0.166666666666667 1.68009734991888 0.117458997605578 0.480550155744441 GO:0051020 GTPase binding 38/1849 315/18639 0.120634920634921 1.21607046279842 0.118971499080911 0.485099277397251 GO:0008083 growth factor activity 21/1849 162/18639 0.12962962962963 1.30674238327024 0.12305419709922 0.495865765960286 GO:0004364 glutathione transferase activity 5/1849 27/18639 0.185185185185185 1.86677483324319 0.123249872464117 0.495865765960286 GO:0023026 MHC class II protein complex binding 5/1849 27/18639 0.185185185185185 1.86677483324319 0.123249872464117 0.495865765960286 GO:0035255 ionotropic glutamate receptor binding 5/1849 27/18639 0.185185185185185 1.86677483324319 0.123249872464117 0.495865765960286 GO:0008375 acetylglucosaminyltransferase activity 7/1849 43/18639 0.162790697674419 1.64102531852541 0.128989082766463 0.513445276957954 GO:0001614 purinergic nucleotide receptor activity 4/1849 20/18639 0.2 2.01611681990265 0.129990170455077 0.513445276957954 GO:0016502 nucleotide receptor activity 4/1849 20/18639 0.2 2.01611681990265 0.129990170455077 0.513445276957954 GO:0005542 folic acid binding 3/1849 13/18639 0.230769230769231 2.32628863834921 0.131435207148609 0.513445276957954 GO:0008035 high-density lipoprotein particle binding 3/1849 13/18639 0.230769230769231 2.32628863834921 0.131435207148609 0.513445276957954 GO:0017154 semaphorin receptor activity 3/1849 13/18639 0.230769230769231 2.32628863834921 0.131435207148609 0.513445276957954 GO:0019855 calcium channel inhibitor activity 3/1849 13/18639 0.230769230769231 2.32628863834921 0.131435207148609 0.513445276957954 GO:0031432 titin binding 3/1849 13/18639 0.230769230769231 2.32628863834921 0.131435207148609 0.513445276957954 GO:0045159 myosin II binding 3/1849 13/18639 0.230769230769231 2.32628863834921 0.131435207148609 0.513445276957954 GO:0051537 2 iron, 2 sulfur cluster binding 5/1849 28/18639 0.178571428571429 1.80010430348451 0.138497725684761 0.537566492962327 GO:0097718 disordered domain specific binding 5/1849 28/18639 0.178571428571429 1.80010430348451 0.138497725684761 0.537566492962327 GO:0044390 ubiquitin-like protein conjugating enzyme binding 6/1849 36/18639 0.166666666666667 1.68009734991888 0.141262831300768 0.54654724825952 GO:0003697 single-stranded DNA binding 16/1849 121/18639 0.132231404958678 1.33296979828274 0.143579083651415 0.551981810482106 GO:0051082 unfolded protein binding 16/1849 121/18639 0.132231404958678 1.33296979828274 0.143579083651415 0.551981810482106 GO:0008373 sialyltransferase activity 4/1849 21/18639 0.19047619047619 1.92011125705014 0.148679997256085 0.562353018263024 GO:0009931 calcium-dependent protein serine/threonine kinase activity 4/1849 21/18639 0.19047619047619 1.92011125705014 0.148679997256085 0.562353018263024 GO:0072542 protein phosphatase activator activity 4/1849 21/18639 0.19047619047619 1.92011125705014 0.148679997256085 0.562353018263024 GO:0140312 cargo adaptor activity 4/1849 21/18639 0.19047619047619 1.92011125705014 0.148679997256085 0.562353018263024 GO:0016860 intramolecular oxidoreductase activity 8/1849 53/18639 0.150943396226415 1.52159759992653 0.150603277744444 0.562353018263024 GO:0004715 non-membrane spanning protein tyrosine kinase activity 7/1849 45/18639 0.155555555555556 1.56809085992428 0.153655611219339 0.562353018263024 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 5/1849 29/18639 0.172413793103448 1.73803174129539 0.154524316452352 0.562353018263024 GO:0005347 ATP transmembrane transporter activity 3/1849 14/18639 0.214285714285714 2.16012516418141 0.155564212318838 0.562353018263024 GO:0005545 1-phosphatidylinositol binding 3/1849 14/18639 0.214285714285714 2.16012516418141 0.155564212318838 0.562353018263024 GO:0008474 palmitoyl-(protein) hydrolase activity 3/1849 14/18639 0.214285714285714 2.16012516418141 0.155564212318838 0.562353018263024 GO:0016530 metallochaperone activity 3/1849 14/18639 0.214285714285714 2.16012516418141 0.155564212318838 0.562353018263024 GO:0019992 diacylglycerol binding 3/1849 14/18639 0.214285714285714 2.16012516418141 0.155564212318838 0.562353018263024 GO:0034236 protein kinase A catalytic subunit binding 3/1849 14/18639 0.214285714285714 2.16012516418141 0.155564212318838 0.562353018263024 GO:0042043 neurexin family protein binding 3/1849 14/18639 0.214285714285714 2.16012516418141 0.155564212318838 0.562353018263024 GO:0042813 Wnt receptor activity 3/1849 14/18639 0.214285714285714 2.16012516418141 0.155564212318838 0.562353018263024 GO:0044548 S100 protein binding 3/1849 14/18639 0.214285714285714 2.16012516418141 0.155564212318838 0.562353018263024 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 3/1849 14/18639 0.214285714285714 2.16012516418141 0.155564212318838 0.562353018263024 GO:0098599 palmitoyl hydrolase activity 3/1849 14/18639 0.214285714285714 2.16012516418141 0.155564212318838 0.562353018263024 GO:0098847 sequence-specific single stranded DNA binding 3/1849 14/18639 0.214285714285714 2.16012516418141 0.155564212318838 0.562353018263024 GO:1990825 sequence-specific mRNA binding 3/1849 14/18639 0.214285714285714 2.16012516418141 0.155564212318838 0.562353018263024 GO:0016247 channel regulator activity 21/1849 168/18639 0.125 1.26007301243916 0.159590206577595 0.575189702873416 GO:0015485 cholesterol binding 8/1849 54/18639 0.148148148148148 1.49341986659456 0.162431618327633 0.583693441527489 GO:0099106 ion channel regulator activity 20/1849 160/18639 0.125 1.26007301243916 0.166620788727267 0.592174009499965 GO:0004180 carboxypeptidase activity 7/1849 46/18639 0.152173913043478 1.5340019281868 0.166747594747719 0.592174009499965 GO:0030276 clathrin binding 7/1849 46/18639 0.152173913043478 1.5340019281868 0.166747594747719 0.592174009499965 GO:0030291 protein serine/threonine kinase inhibitor activity 7/1849 46/18639 0.152173913043478 1.5340019281868 0.166747594747719 0.592174009499965 GO:0003727 single-stranded RNA binding 12/1849 89/18639 0.134831460674157 1.35917987858606 0.169374505382229 0.599744228122453 GO:0042887 amide transmembrane transporter activity 6/1849 38/18639 0.157894736842105 1.59167117360736 0.17002659316858 0.600297971799273 GO:0004725 protein tyrosine phosphatase activity 13/1849 98/18639 0.13265306122449 1.33722033973135 0.171392618166775 0.603361804069665 GO:0141108 transporter regulator activity 21/1849 170/18639 0.123529411764706 1.24524862405752 0.172965454934373 0.607133814276886 GO:0030971 receptor tyrosine kinase binding 11/1849 81/18639 0.135802469135802 1.36896821104501 0.176624848883418 0.618186971091965 GO:0004089 carbonate dehydratase activity 3/1849 15/18639 0.2 2.01611681990265 0.180924606450909 0.618925701728956 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 3/1849 15/18639 0.2 2.01611681990265 0.180924606450909 0.618925701728956 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3/1849 15/18639 0.2 2.01611681990265 0.180924606450909 0.618925701728956 GO:0015116 sulfate transmembrane transporter activity 3/1849 15/18639 0.2 2.01611681990265 0.180924606450909 0.618925701728956 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 3/1849 15/18639 0.2 2.01611681990265 0.180924606450909 0.618925701728956 GO:0016846 carbon-sulfur lyase activity 3/1849 15/18639 0.2 2.01611681990265 0.180924606450909 0.618925701728956 GO:0034483 heparan sulfate sulfotransferase activity 3/1849 15/18639 0.2 2.01611681990265 0.180924606450909 0.618925701728956 GO:0050780 dopamine receptor binding 3/1849 15/18639 0.2 2.01611681990265 0.180924606450909 0.618925701728956 GO:0019902 phosphatase binding 23/1849 190/18639 0.121052631578947 1.22028123309897 0.184515141927192 0.624742008609841 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 6/1849 39/18639 0.153846153846154 1.55085909223281 0.185251364077573 0.624742008609841 GO:0008201 heparin binding 21/1849 172/18639 0.122093023255814 1.23076898889406 0.186912679747731 0.624742008609841 GO:0019212 phosphatase inhibitor activity 8/1849 56/18639 0.142857142857143 1.44008344278761 0.187314980973903 0.624742008609841 GO:0170055 lipid transmembrane transporter activity 8/1849 56/18639 0.142857142857143 1.44008344278761 0.187314980973903 0.624742008609841 GO:0005164 tumor necrosis factor receptor binding 5/1849 31/18639 0.161290322580645 1.62590066121181 0.188683536087195 0.624742008609841 GO:0070325 lipoprotein particle receptor binding 5/1849 31/18639 0.161290322580645 1.62590066121181 0.188683536087195 0.624742008609841 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 12/1849 91/18639 0.131868131868132 1.32930779334241 0.188808178976764 0.624742008609841 GO:0005158 insulin receptor binding 4/1849 23/18639 0.173913043478261 1.75314506078491 0.188815503840794 0.624742008609841 GO:0016493 C-C chemokine receptor activity 4/1849 23/18639 0.173913043478261 1.75314506078491 0.188815503840794 0.624742008609841 GO:0043274 phospholipase binding 4/1849 23/18639 0.173913043478261 1.75314506078491 0.188815503840794 0.624742008609841 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 4/1849 23/18639 0.173913043478261 1.75314506078491 0.188815503840794 0.624742008609841 GO:1901681 sulfur compound binding 32/1849 275/18639 0.116363636363636 1.17301342248881 0.193505514735899 0.638515472330175 GO:0140693 molecular condensate scaffold activity 7/1849 48/18639 0.145833333333333 1.47008518117902 0.194320487982252 0.639462258006813 GO:0043178 alcohol binding 12/1849 92/18639 0.130434782608696 1.31485879558868 0.198896210591793 0.652746100343255 GO:0030331 nuclear estrogen receptor binding 6/1849 40/18639 0.15 1.51208761492699 0.200984662557582 0.657817368533059 GO:0008235 metalloexopeptidase activity 9/1849 66/18639 0.136363636363636 1.37462510447908 0.204306215421615 0.66036401054055 GO:0031369 translation initiation factor binding 5/1849 32/18639 0.15625 1.57509126554895 0.206692409217072 0.66036401054055 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 3/1849 16/18639 0.1875 1.89010951865873 0.207286168005967 0.66036401054055 GO:0005521 lamin binding 3/1849 16/18639 0.1875 1.89010951865873 0.207286168005967 0.66036401054055 GO:0031435 mitogen-activated protein kinase kinase kinase binding 3/1849 16/18639 0.1875 1.89010951865873 0.207286168005967 0.66036401054055 GO:0034450 ubiquitin-ubiquitin ligase activity 3/1849 16/18639 0.1875 1.89010951865873 0.207286168005967 0.66036401054055 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 3/1849 16/18639 0.1875 1.89010951865873 0.207286168005967 0.66036401054055 GO:0035254 glutamate receptor binding 7/1849 49/18639 0.142857142857143 1.44008344278761 0.208744143465262 0.66036401054055 GO:0060590 ATPase regulator activity 7/1849 49/18639 0.142857142857143 1.44008344278761 0.208744143465262 0.66036401054055 GO:0001091 RNA polymerase II general transcription initiation factor binding 4/1849 24/18639 0.166666666666667 1.68009734991888 0.210045232885233 0.66036401054055 GO:0015295 solute:proton symporter activity 4/1849 24/18639 0.166666666666667 1.68009734991888 0.210045232885233 0.66036401054055 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 4/1849 24/18639 0.166666666666667 1.68009734991888 0.210045232885233 0.66036401054055 GO:0019957 C-C chemokine binding 4/1849 24/18639 0.166666666666667 1.68009734991888 0.210045232885233 0.66036401054055 GO:0030215 semaphorin receptor binding 4/1849 24/18639 0.166666666666667 1.68009734991888 0.210045232885233 0.66036401054055 GO:0030552 cAMP binding 4/1849 24/18639 0.166666666666667 1.68009734991888 0.210045232885233 0.66036401054055 GO:0042578 phosphoric ester hydrolase activity 41/1849 363/18639 0.112947658402204 1.13857836936651 0.210487620205328 0.66036401054055 GO:0042287 MHC protein binding 6/1849 41/18639 0.146341463414634 1.47520742919706 0.217183822225523 0.677859816276052 GO:0140318 protein transporter activity 6/1849 41/18639 0.146341463414634 1.47520742919706 0.217183822225523 0.677859816276052 GO:0017022 myosin binding 10/1849 76/18639 0.131578947368421 1.3263926446728 0.218618382274873 0.680583190063936 GO:0031072 heat shock protein binding 16/1849 131/18639 0.122137404580153 1.2312163785665 0.225770679635626 0.694111109853016 GO:0001786 phosphatidylserine binding 8/1849 59/18639 0.135593220338983 1.36685886095095 0.227390080420472 0.694111109853016 GO:0070888 E-box binding 8/1849 59/18639 0.135593220338983 1.36685886095095 0.227390080420472 0.694111109853016 GO:0032934 sterol binding 9/1849 68/18639 0.132352941176471 1.33419495434734 0.229573467108455 0.694111109853016 GO:0015662 P-type ion transporter activity 4/1849 25/18639 0.16 1.61289345592212 0.231903031500803 0.694111109853016 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 4/1849 25/18639 0.16 1.61289345592212 0.231903031500803 0.694111109853016 GO:0017025 TBP-class protein binding 4/1849 25/18639 0.16 1.61289345592212 0.231903031500803 0.694111109853016 GO:0019211 phosphatase activator activity 4/1849 25/18639 0.16 1.61289345592212 0.231903031500803 0.694111109853016 GO:0042974 nuclear retinoic acid receptor binding 4/1849 25/18639 0.16 1.61289345592212 0.231903031500803 0.694111109853016 GO:0120020 cholesterol transfer activity 4/1849 25/18639 0.16 1.61289345592212 0.231903031500803 0.694111109853016 GO:0140358 P-type transmembrane transporter activity 4/1849 25/18639 0.16 1.61289345592212 0.231903031500803 0.694111109853016 GO:0016859 cis-trans isomerase activity 6/1849 42/18639 0.142857142857143 1.44008344278761 0.233804626328847 0.694111109853016 GO:0042056 chemoattractant activity 6/1849 42/18639 0.142857142857143 1.44008344278761 0.233804626328847 0.694111109853016 GO:0051879 Hsp90 protein binding 6/1849 42/18639 0.142857142857143 1.44008344278761 0.233804626328847 0.694111109853016 GO:0015347 sodium-independent organic anion transmembrane transporter activity 3/1849 17/18639 0.176470588235294 1.77892660579646 0.23442728648215 0.694111109853016 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/1849 17/18639 0.176470588235294 1.77892660579646 0.23442728648215 0.694111109853016 GO:0038191 neuropilin binding 3/1849 17/18639 0.176470588235294 1.77892660579646 0.23442728648215 0.694111109853016 GO:0045125 bioactive lipid receptor activity 3/1849 17/18639 0.176470588235294 1.77892660579646 0.23442728648215 0.694111109853016 GO:0046965 nuclear retinoid X receptor binding 3/1849 17/18639 0.176470588235294 1.77892660579646 0.23442728648215 0.694111109853016 GO:1990226 histone methyltransferase binding 3/1849 17/18639 0.176470588235294 1.77892660579646 0.23442728648215 0.694111109853016 GO:0004866 endopeptidase inhibitor activity 19/1849 161/18639 0.118012422360248 1.18963414838976 0.24545439389871 0.714975454409013 GO:0035173 histone kinase activity 40/1849 360/18639 0.111111111111111 1.12006489994592 0.246085494881964 0.714975454409013 GO:0005261 monoatomic cation channel activity 38/1849 341/18639 0.111436950146628 1.12334954774634 0.246852874311221 0.714975454409013 GO:0048156 tau protein binding 6/1849 43/18639 0.13953488372093 1.40659313016464 0.250801741501126 0.714975454409013 GO:0005126 cytokine receptor binding 31/1849 275/18639 0.112727272727273 1.13635675303604 0.251603921765703 0.714975454409013 GO:0004435 phosphatidylinositol phospholipase C activity 4/1849 26/18639 0.153846153846154 1.55085909223281 0.254279482326214 0.714975454409013 GO:0005112 Notch binding 4/1849 26/18639 0.153846153846154 1.55085909223281 0.254279482326214 0.714975454409013 GO:0030247 polysaccharide binding 4/1849 26/18639 0.153846153846154 1.55085909223281 0.254279482326214 0.714975454409013 GO:0050750 low-density lipoprotein particle receptor binding 4/1849 26/18639 0.153846153846154 1.55085909223281 0.254279482326214 0.714975454409013 GO:0005216 monoatomic ion channel activity 49/1849 448/18639 0.109375 1.10256388588426 0.254309964113256 0.714975454409013 GO:0008028 monocarboxylic acid transmembrane transporter activity 9/1849 70/18639 0.128571428571429 1.29607509850885 0.255915603960723 0.714975454409013 GO:0019903 protein phosphatase binding 17/1849 144/18639 0.118055555555556 1.19006895619254 0.260248165401783 0.714975454409013 GO:0001094 TFIID-class transcription factor complex binding 2/1849 10/18639 0.2 2.01611681990265 0.260794304383283 0.714975454409013 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/1849 10/18639 0.2 2.01611681990265 0.260794304383283 0.714975454409013 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/1849 10/18639 0.2 2.01611681990265 0.260794304383283 0.714975454409013 GO:0004935 adrenergic receptor activity 2/1849 10/18639 0.2 2.01611681990265 0.260794304383283 0.714975454409013 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/1849 10/18639 0.2 2.01611681990265 0.260794304383283 0.714975454409013 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/1849 10/18639 0.2 2.01611681990265 0.260794304383283 0.714975454409013 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/1849 10/18639 0.2 2.01611681990265 0.260794304383283 0.714975454409013 GO:0019911 structural constituent of myelin sheath 2/1849 10/18639 0.2 2.01611681990265 0.260794304383283 0.714975454409013 GO:0030957 Tat protein binding 2/1849 10/18639 0.2 2.01611681990265 0.260794304383283 0.714975454409013 GO:0032356 oxidized DNA binding 2/1849 10/18639 0.2 2.01611681990265 0.260794304383283 0.714975454409013 GO:0043208 glycosphingolipid binding 2/1849 10/18639 0.2 2.01611681990265 0.260794304383283 0.714975454409013 GO:0043422 protein kinase B binding 2/1849 10/18639 0.2 2.01611681990265 0.260794304383283 0.714975454409013 GO:0047429 nucleoside triphosphate diphosphatase activity 2/1849 10/18639 0.2 2.01611681990265 0.260794304383283 0.714975454409013 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/1849 10/18639 0.2 2.01611681990265 0.260794304383283 0.714975454409013 GO:0098505 G-rich strand telomeric DNA binding 2/1849 10/18639 0.2 2.01611681990265 0.260794304383283 0.714975454409013 GO:0019888 protein phosphatase regulator activity 13/1849 107/18639 0.121495327102804 1.22474386255768 0.261612469515458 0.714975454409013 GO:0000400 four-way junction DNA binding 3/1849 18/18639 0.166666666666667 1.68009734991888 0.262137986587615 0.714975454409013 GO:0004970 glutamate-gated receptor activity 3/1849 18/18639 0.166666666666667 1.68009734991888 0.262137986587615 0.714975454409013 GO:0016854 racemase and epimerase activity 3/1849 18/18639 0.166666666666667 1.68009734991888 0.262137986587615 0.714975454409013 GO:0017075 syntaxin-1 binding 3/1849 18/18639 0.166666666666667 1.68009734991888 0.262137986587615 0.714975454409013 GO:0034185 apolipoprotein binding 3/1849 18/18639 0.166666666666667 1.68009734991888 0.262137986587615 0.714975454409013 GO:0070064 proline-rich region binding 3/1849 18/18639 0.166666666666667 1.68009734991888 0.262137986587615 0.714975454409013 GO:1990381 ubiquitin-specific protease binding 3/1849 18/18639 0.166666666666667 1.68009734991888 0.262137986587615 0.714975454409013 GO:0015297 antiporter activity 16/1849 135/18639 0.118518518518519 1.19473589327564 0.263357606509458 0.715207196297219 GO:0005154 epidermal growth factor receptor binding 5/1849 35/18639 0.142857142857143 1.44008344278761 0.263650108254833 0.715207196297219 GO:0042626 ATPase-coupled transmembrane transporter activity 12/1849 98/18639 0.122448979591837 1.23435723667509 0.263994728938775 0.715207196297219 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 11/1849 89/18639 0.123595505617978 1.24591488870388 0.266163224000776 0.716310105400582 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 11/1849 89/18639 0.123595505617978 1.24591488870388 0.266163224000776 0.716310105400582 GO:0005506 iron ion binding 18/1849 154/18639 0.116883116883117 1.1782500895535 0.266176339744229 0.716310105400582 GO:0019205 nucleobase-containing compound kinase activity 6/1849 44/18639 0.136363636363636 1.37462510447908 0.268129130569928 0.718372515752616 GO:0030020 extracellular matrix structural constituent conferring tensile strength 6/1849 44/18639 0.136363636363636 1.37462510447908 0.268129130569928 0.718372515752616 GO:0004864 protein phosphatase inhibitor activity 7/1849 53/18639 0.132075471698113 1.33139789993571 0.269952646951368 0.71848935265518 GO:0008146 sulfotransferase activity 7/1849 53/18639 0.132075471698113 1.33139789993571 0.269952646951368 0.71848935265518 GO:0140296 general transcription initiation factor binding 7/1849 53/18639 0.132075471698113 1.33139789993571 0.269952646951368 0.71848935265518 GO:0140789 histone phosphatase activity 16/1849 136/18639 0.117647058823529 1.18595107053097 0.273097674533525 0.725265973377409 GO:0008514 organic anion transmembrane transporter activity 30/1849 269/18639 0.111524163568773 1.12422870998289 0.275582928372038 0.729409626786772 GO:0042826 histone deacetylase binding 15/1849 127/18639 0.118110236220472 1.19062016923385 0.276606392124478 0.729409626786772 GO:0008266 poly(U) RNA binding 4/1849 27/18639 0.148148148148148 1.49341986659456 0.277067240563101 0.729409626786772 GO:0008320 protein transmembrane transporter activity 4/1849 27/18639 0.148148148148148 1.49341986659456 0.277067240563101 0.729409626786772 GO:0140793 histone H2AXY142 phosphatase activity 11/1849 90/18639 0.122222222222222 1.23207138994051 0.27830479397661 0.729912400418059 GO:0016922 nuclear receptor binding 16/1849 137/18639 0.116788321167883 1.17729449337381 0.282960673305098 0.729912400418059 GO:0004869 cysteine-type endopeptidase inhibitor activity 5/1849 36/18639 0.138888888888889 1.4000811249324 0.283389991634521 0.729912400418059 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 5/1849 36/18639 0.138888888888889 1.4000811249324 0.283389991634521 0.729912400418059 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 5/1849 36/18639 0.138888888888889 1.4000811249324 0.283389991634521 0.729912400418059 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 5/1849 36/18639 0.138888888888889 1.4000811249324 0.283389991634521 0.729912400418059 GO:0004620 phospholipase activity 13/1849 109/18639 0.119266055045872 1.20227149810709 0.283660457744242 0.729912400418059 GO:0140996 histone H3 kinase activity 39/1849 357/18639 0.109243697478992 1.10124027977876 0.285199217090891 0.729912400418059 GO:0008009 chemokine activity 6/1849 45/18639 0.133333333333333 1.3440778799351 0.285740441239249 0.729912400418059 GO:0005346 purine ribonucleotide transmembrane transporter activity 3/1849 19/18639 0.157894736842105 1.59167117360736 0.29022202442408 0.729912400418059 GO:0042834 peptidoglycan binding 3/1849 19/18639 0.157894736842105 1.59167117360736 0.29022202442408 0.729912400418059 GO:0004222 metalloendopeptidase activity 13/1849 110/18639 0.118181818181818 1.1913417572152 0.294895868501764 0.729912400418059 GO:0016874 ligase activity 19/1849 167/18639 0.11377245508982 1.14689280174103 0.298717697940846 0.729912400418059 GO:0004016 adenylate cyclase activity 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0005114 type II transforming growth factor beta receptor binding 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0008172 S-methyltransferase activity 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0008199 ferric iron binding 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0008432 JUN kinase binding 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0008503 benzodiazepine receptor activity 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0019206 nucleoside kinase activity 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0032050 clathrin heavy chain binding 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0032404 mismatch repair complex binding 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0035252 UDP-xylosyltransferase activity 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0042285 xylosyltransferase activity 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0042608 T cell receptor binding 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0048407 platelet-derived growth factor binding 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0070697 activin receptor binding 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0070990 snRNP binding 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0097493 structural molecule activity conferring elasticity 2/1849 11/18639 0.181818181818182 1.83283347263877 0.29923549823529 0.729912400418059 GO:0046982 protein heterodimerization activity 40/1849 369/18639 0.10840108401084 1.09274624384967 0.299504802331867 0.729912400418059 GO:0046625 sphingolipid binding 4/1849 28/18639 0.142857142857143 1.44008344278761 0.300162159709491 0.729912400418059 GO:0050698 proteoglycan sulfotransferase activity 4/1849 28/18639 0.142857142857143 1.44008344278761 0.300162159709491 0.729912400418059 GO:0023023 MHC protein complex binding 5/1849 37/18639 0.135135135135135 1.36224109452882 0.303396081714359 0.734825309912177 GO:0030551 cyclic nucleotide binding 5/1849 37/18639 0.135135135135135 1.36224109452882 0.303396081714359 0.734825309912177 GO:0005326 neurotransmitter transmembrane transporter activity 3/1849 20/18639 0.15 1.51208761492699 0.318498233948022 0.765544170820874 GO:0016408 C-acyltransferase activity 3/1849 20/18639 0.15 1.51208761492699 0.318498233948022 0.765544170820874 GO:0042288 MHC class I protein binding 3/1849 20/18639 0.15 1.51208761492699 0.318498233948022 0.765544170820874 GO:0030170 pyridoxal phosphate binding 7/1849 56/18639 0.125 1.26007301243916 0.318607978607531 0.765544170820874 GO:0051117 ATPase binding 10/1849 84/18639 0.119047619047619 1.20006953565634 0.320489400131667 0.768539927840493 GO:0043495 protein-membrane adaptor activity 6/1849 47/18639 0.127659574468085 1.28688307653361 0.321629987005074 0.769750818701866 GO:0051861 glycolipid binding 4/1849 29/18639 0.137931034482759 1.39042539303631 0.323464214630633 0.769909499713973 GO:0099604 ligand-gated calcium channel activity 4/1849 29/18639 0.137931034482759 1.39042539303631 0.323464214630633 0.769909499713973 GO:0000146 microfilament motor activity 5/1849 38/18639 0.131578947368421 1.3263926446728 0.323603579978871 0.769909499713973 GO:0141003 histone H2AX kinase activity 38/1849 354/18639 0.107344632768362 1.08209659825283 0.327621189197054 0.773682546842246 GO:0001216 DNA-binding transcription activator activity 52/1849 491/18639 0.105906313645621 1.06759750137411 0.328892758482434 0.773682546842246 GO:0016757 glycosyltransferase activity 29/1849 267/18639 0.108614232209738 1.09489490219432 0.330991612079424 0.773682546842246 GO:0070279 vitamin B6 binding 7/1849 57/18639 0.12280701754386 1.23796646836128 0.335167019143174 0.773682546842246 GO:0004300 enoyl-CoA hydratase activity 2/1849 12/18639 0.166666666666667 1.68009734991888 0.337328145939476 0.773682546842246 GO:0004859 phospholipase inhibitor activity 2/1849 12/18639 0.166666666666667 1.68009734991888 0.337328145939476 0.773682546842246 GO:0005025 transforming growth factor beta receptor activity, type I 2/1849 12/18639 0.166666666666667 1.68009734991888 0.337328145939476 0.773682546842246 GO:0005026 transforming growth factor beta receptor activity, type II 2/1849 12/18639 0.166666666666667 1.68009734991888 0.337328145939476 0.773682546842246 GO:0005049 nuclear export signal receptor activity 2/1849 12/18639 0.166666666666667 1.68009734991888 0.337328145939476 0.773682546842246 GO:0008603 cAMP-dependent protein kinase regulator activity 2/1849 12/18639 0.166666666666667 1.68009734991888 0.337328145939476 0.773682546842246 GO:0015132 prostaglandin transmembrane transporter activity 2/1849 12/18639 0.166666666666667 1.68009734991888 0.337328145939476 0.773682546842246 GO:0016361 activin receptor activity, type I 2/1849 12/18639 0.166666666666667 1.68009734991888 0.337328145939476 0.773682546842246 GO:0016362 activin receptor activity, type II 2/1849 12/18639 0.166666666666667 1.68009734991888 0.337328145939476 0.773682546842246 GO:0017002 activin receptor activity 2/1849 12/18639 0.166666666666667 1.68009734991888 0.337328145939476 0.773682546842246 GO:0034452 dynactin binding 2/1849 12/18639 0.166666666666667 1.68009734991888 0.337328145939476 0.773682546842246 GO:0043047 single-stranded telomeric DNA binding 2/1849 12/18639 0.166666666666667 1.68009734991888 0.337328145939476 0.773682546842246 GO:0045295 gamma-catenin binding 2/1849 12/18639 0.166666666666667 1.68009734991888 0.337328145939476 0.773682546842246 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/1849 12/18639 0.166666666666667 1.68009734991888 0.337328145939476 0.773682546842246 GO:0070410 co-SMAD binding 2/1849 12/18639 0.166666666666667 1.68009734991888 0.337328145939476 0.773682546842246 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 6/1849 48/18639 0.125 1.26007301243916 0.339817058294049 0.777917689213787 GO:0004867 serine-type endopeptidase inhibitor activity 11/1849 95/18639 0.115789473684211 1.16722552731206 0.341174035723671 0.779349808496215 GO:0000217 DNA secondary structure binding 5/1849 39/18639 0.128205128205128 1.29238257686067 0.343949494082003 0.779349808496215 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 5/1849 39/18639 0.128205128205128 1.29238257686067 0.343949494082003 0.779349808496215 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 51/1849 484/18639 0.105371900826446 1.06221030800656 0.344686770870395 0.779349808496215 GO:0061891 calcium ion sensor activity 3/1849 21/18639 0.142857142857143 1.44008344278761 0.346801273396678 0.779349808496215 GO:0070182 DNA polymerase binding 3/1849 21/18639 0.142857142857143 1.44008344278761 0.346801273396678 0.779349808496215 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 4/1849 30/18639 0.133333333333333 1.3440778799351 0.346878238463633 0.779349808496215 GO:0008187 poly-pyrimidine tract binding 4/1849 30/18639 0.133333333333333 1.3440778799351 0.346878238463633 0.779349808496215 GO:0031210 phosphatidylcholine binding 4/1849 30/18639 0.133333333333333 1.3440778799351 0.346878238463633 0.779349808496215 GO:0031624 ubiquitin conjugating enzyme binding 4/1849 30/18639 0.133333333333333 1.3440778799351 0.346878238463633 0.779349808496215 GO:0016763 pentosyltransferase activity 6/1849 49/18639 0.122448979591837 1.23435723667509 0.358106302223646 0.803086540727473 GO:0000149 SNARE binding 12/1849 106/18639 0.113207547169811 1.1411981999449 0.359688317998652 0.805143351379608 GO:0004177 aminopeptidase activity 5/1849 40/18639 0.125 1.26007301243916 0.364373041442634 0.809452900505315 GO:0071855 neuropeptide receptor binding 5/1849 40/18639 0.125 1.26007301243916 0.364373041442634 0.809452900505315 GO:0008237 metallopeptidase activity 20/1849 184/18639 0.108695652173913 1.09571566299057 0.367577558568161 0.809452900505315 GO:0015459 potassium channel regulator activity 7/1849 59/18639 0.11864406779661 1.19600150333208 0.368592420574039 0.809452900505315 GO:0005452 solute:inorganic anion antiporter activity 4/1849 31/18639 0.129032258064516 1.30072052896945 0.370314490667549 0.809452900505315 GO:0004721 phosphoprotein phosphatase activity 19/1849 175/18639 0.108571428571429 1.09446341651858 0.374492043558884 0.809452900505315 GO:0008417 fucosyltransferase activity 2/1849 13/18639 0.153846153846154 1.55085909223281 0.374763225719634 0.809452900505315 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/1849 13/18639 0.153846153846154 1.55085909223281 0.374763225719634 0.809452900505315 GO:0031994 insulin-like growth factor I binding 2/1849 13/18639 0.153846153846154 1.55085909223281 0.374763225719634 0.809452900505315 GO:0039706 co-receptor binding 2/1849 13/18639 0.153846153846154 1.55085909223281 0.374763225719634 0.809452900505315 GO:0043560 insulin receptor substrate binding 2/1849 13/18639 0.153846153846154 1.55085909223281 0.374763225719634 0.809452900505315 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/1849 13/18639 0.153846153846154 1.55085909223281 0.374763225719634 0.809452900505315 GO:0070123 transforming growth factor beta receptor activity, type III 2/1849 13/18639 0.153846153846154 1.55085909223281 0.374763225719634 0.809452900505315 GO:0071714 icosanoid transmembrane transporter activity 2/1849 13/18639 0.153846153846154 1.55085909223281 0.374763225719634 0.809452900505315 GO:0089720 caspase binding 2/1849 13/18639 0.153846153846154 1.55085909223281 0.374763225719634 0.809452900505315 GO:0140333 glycerophospholipid flippase activity 2/1849 13/18639 0.153846153846154 1.55085909223281 0.374763225719634 0.809452900505315 GO:0005243 gap junction channel activity 3/1849 22/18639 0.136363636363636 1.37462510447908 0.374981896931033 0.809452900505315 GO:0008970 phospholipase A1 activity 3/1849 22/18639 0.136363636363636 1.37462510447908 0.374981896931033 0.809452900505315 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 3/1849 22/18639 0.136363636363636 1.37462510447908 0.374981896931033 0.809452900505315 GO:0140784 metal ion sensor activity 3/1849 22/18639 0.136363636363636 1.37462510447908 0.374981896931033 0.809452900505315 GO:0032813 tumor necrosis factor receptor superfamily binding 6/1849 50/18639 0.12 1.20967009194159 0.376454642529236 0.811186071357482 GO:0008227 G protein-coupled amine receptor activity 5/1849 41/18639 0.121951219512195 1.22933952433088 0.384815988556121 0.826262698832381 GO:0017080 sodium channel regulator activity 5/1849 41/18639 0.121951219512195 1.22933952433088 0.384815988556121 0.826262698832381 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 14/1849 128/18639 0.109375 1.10256388588426 0.391719251335219 0.83959648383531 GO:0008378 galactosyltransferase activity 4/1849 32/18639 0.125 1.26007301243916 0.393689073731904 0.840842095748387 GO:0120015 sterol transfer activity 4/1849 32/18639 0.125 1.26007301243916 0.393689073731904 0.840842095748387 GO:0005272 sodium channel activity 6/1849 51/18639 0.117647058823529 1.18595107053097 0.394820420782647 0.841773819661595 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 7/1849 61/18639 0.114754098360656 1.15678833928841 0.402209373756899 0.85141869040092 GO:0016836 hydro-lyase activity 7/1849 61/18639 0.114754098360656 1.15678833928841 0.402209373756899 0.85141869040092 GO:0000295 adenine nucleotide transmembrane transporter activity 3/1849 23/18639 0.130434782608696 1.31485879558868 0.40290685589457 0.85141869040092 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 3/1849 23/18639 0.130434782608696 1.31485879558868 0.40290685589457 0.85141869040092 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 3/1849 23/18639 0.130434782608696 1.31485879558868 0.40290685589457 0.85141869040092 GO:0031492 nucleosomal DNA binding 5/1849 42/18639 0.119047619047619 1.20006953565634 0.405222929397645 0.85141869040092 GO:0035198 miRNA binding 5/1849 42/18639 0.119047619047619 1.20006953565634 0.405222929397645 0.85141869040092 GO:0046943 carboxylic acid transmembrane transporter activity 20/1849 188/18639 0.106382978723404 1.07240256377801 0.405498765196662 0.85141869040092 GO:0140299 molecular sensor activity 8/1849 71/18639 0.112676056338028 1.13584046191699 0.407923016412615 0.85141869040092 GO:0015291 secondary active transmembrane transporter activity 30/1849 287/18639 0.104529616724739 1.05371959228362 0.409249473790281 0.85141869040092 GO:0005161 platelet-derived growth factor receptor binding 2/1849 14/18639 0.142857142857143 1.44008344278761 0.411296394619767 0.85141869040092 GO:0008331 high voltage-gated calcium channel activity 2/1849 14/18639 0.142857142857143 1.44008344278761 0.411296394619767 0.85141869040092 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/1849 14/18639 0.142857142857143 1.44008344278761 0.411296394619767 0.85141869040092 GO:0030983 mismatched DNA binding 2/1849 14/18639 0.142857142857143 1.44008344278761 0.411296394619767 0.85141869040092 GO:0031404 chloride ion binding 2/1849 14/18639 0.142857142857143 1.44008344278761 0.411296394619767 0.85141869040092 GO:0071933 Arp2/3 complex binding 2/1849 14/18639 0.142857142857143 1.44008344278761 0.411296394619767 0.85141869040092 GO:0098821 BMP receptor activity 2/1849 14/18639 0.142857142857143 1.44008344278761 0.411296394619767 0.85141869040092 GO:0005342 organic acid transmembrane transporter activity 20/1849 189/18639 0.105820105820106 1.06672847613897 0.415044700263335 0.857711829383785 GO:1902936 phosphatidylinositol bisphosphate binding 12/1849 111/18639 0.108108108108108 1.08979287562305 0.422008489597946 0.870617173599851 GO:0015108 chloride transmembrane transporter activity 13/1849 121/18639 0.107438016528926 1.08303796110473 0.424287056542652 0.873829295022366 GO:0004622 lysophospholipase activity 3/1849 24/18639 0.125 1.26007301243916 0.430458516324475 0.879597471604189 GO:0035035 histone acetyltransferase binding 3/1849 24/18639 0.125 1.26007301243916 0.430458516324475 0.879597471604189 GO:0050699 WW domain binding 3/1849 24/18639 0.125 1.26007301243916 0.430458516324475 0.879597471604189 GO:0070300 phosphatidic acid binding 3/1849 24/18639 0.125 1.26007301243916 0.430458516324475 0.879597471604189 GO:0005246 calcium channel regulator activity 6/1849 53/18639 0.113207547169811 1.1411981999449 0.431445828350858 0.879597471604189 GO:0005544 calcium-dependent phospholipid binding 6/1849 53/18639 0.113207547169811 1.1411981999449 0.431445828350858 0.879597471604189 GO:0015171 amino acid transmembrane transporter activity 11/1849 102/18639 0.107843137254902 1.08712181465339 0.432465970147973 0.880195445124699 GO:0030332 cyclin binding 4/1849 34/18639 0.117647058823529 1.18595107053097 0.439948435816075 0.893922073445078 GO:0016790 thiolester hydrolase activity 5/1849 44/18639 0.113636363636364 1.14552092039923 0.445722580622004 0.900166339619092 GO:0000774 adenyl-nucleotide exchange factor activity 2/1849 15/18639 0.133333333333333 1.3440778799351 0.446738208184207 0.900166339619092 GO:0017081 chloride channel regulator activity 2/1849 15/18639 0.133333333333333 1.3440778799351 0.446738208184207 0.900166339619092 GO:0048531 beta-1,3-galactosyltransferase activity 2/1849 15/18639 0.133333333333333 1.3440778799351 0.446738208184207 0.900166339619092 GO:0120283 protein serine/threonine kinase binding 2/1849 15/18639 0.133333333333333 1.3440778799351 0.446738208184207 0.900166339619092 GO:0031267 small GTPase binding 29/1849 283/18639 0.102473498233216 1.03299271691125 0.455724096747405 0.916747310898849 GO:0004709 MAP kinase kinase kinase activity 3/1849 25/18639 0.12 1.20967009194159 0.457534264254976 0.917341049690026 GO:0015271 outward rectifier potassium channel activity 3/1849 25/18639 0.12 1.20967009194159 0.457534264254976 0.917341049690026 GO:0042605 peptide antigen binding 5/1849 45/18639 0.111111111111111 1.12006489994592 0.465720348044849 0.932210481788945 GO:0003725 double-stranded RNA binding 8/1849 75/18639 0.106666666666667 1.07526230394808 0.470008735987184 0.935479378514541 GO:0044183 protein folding chaperone 8/1849 75/18639 0.106666666666667 1.07526230394808 0.470008735987184 0.935479378514541 GO:0015103 inorganic anion transmembrane transporter activity 17/1849 165/18639 0.103030303030303 1.0386056344953 0.472494600033917 0.935479378514541 GO:0005024 transforming growth factor beta receptor activity 2/1849 16/18639 0.125 1.26007301243916 0.480945642495384 0.935479378514541 GO:0015562 efflux transmembrane transporter activity 2/1849 16/18639 0.125 1.26007301243916 0.480945642495384 0.935479378514541 GO:0015923 mannosidase activity 2/1849 16/18639 0.125 1.26007301243916 0.480945642495384 0.935479378514541 GO:0016722 oxidoreductase activity, acting on metal ions 2/1849 16/18639 0.125 1.26007301243916 0.480945642495384 0.935479378514541 GO:0019841 retinol binding 2/1849 16/18639 0.125 1.26007301243916 0.480945642495384 0.935479378514541 GO:0022841 potassium ion leak channel activity 2/1849 16/18639 0.125 1.26007301243916 0.480945642495384 0.935479378514541 GO:0055102 lipase inhibitor activity 2/1849 16/18639 0.125 1.26007301243916 0.480945642495384 0.935479378514541 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 2/1849 16/18639 0.125 1.26007301243916 0.480945642495384 0.935479378514541 GO:0140327 flippase activity 2/1849 16/18639 0.125 1.26007301243916 0.480945642495384 0.935479378514541 GO:0140328 floppase activity 2/1849 16/18639 0.125 1.26007301243916 0.480945642495384 0.935479378514541 GO:0008066 glutamate receptor activity 3/1849 26/18639 0.115384615384615 1.16314431917461 0.484045757550031 0.935479378514541 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/1849 26/18639 0.115384615384615 1.16314431917461 0.484045757550031 0.935479378514541 GO:0008143 poly(A) binding 3/1849 26/18639 0.115384615384615 1.16314431917461 0.484045757550031 0.935479378514541 GO:0015216 purine nucleotide transmembrane transporter activity 3/1849 26/18639 0.115384615384615 1.16314431917461 0.484045757550031 0.935479378514541 GO:0043548 phosphatidylinositol 3-kinase binding 3/1849 26/18639 0.115384615384615 1.16314431917461 0.484045757550031 0.935479378514541 GO:0052742 phosphatidylinositol kinase activity 3/1849 26/18639 0.115384615384615 1.16314431917461 0.484045757550031 0.935479378514541 GO:0070006 metalloaminopeptidase activity 3/1849 26/18639 0.115384615384615 1.16314431917461 0.484045757550031 0.935479378514541 GO:0070412 R-SMAD binding 3/1849 26/18639 0.115384615384615 1.16314431917461 0.484045757550031 0.935479378514541 GO:0005484 SNAP receptor activity 4/1849 36/18639 0.111111111111111 1.12006489994592 0.485109934049272 0.935479378514541 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 9/1849 86/18639 0.104651162790698 1.05494484762348 0.485120602565757 0.935479378514541 GO:0016758 hexosyltransferase activity 20/1849 197/18639 0.101522842639594 1.02340955325008 0.491476819754233 0.946229616410772 GO:0043021 ribonucleoprotein complex binding 18/1849 177/18639 0.101694915254237 1.02514414571321 0.492583549964093 0.946855046042089 GO:0030594 neurotransmitter receptor activity 10/1849 97/18639 0.103092783505155 1.03923547417662 0.498416390007153 0.9565487294749 GO:0051540 metal cluster binding 8/1849 77/18639 0.103896103896104 1.04733341293644 0.500543246840257 0.959110556841061 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 7/1849 67/18639 0.104477611940299 1.05319535368049 0.50180828064551 0.959971451385367 GO:0005319 lipid transporter activity 18/1849 178/18639 0.101123595505618 1.01938490893954 0.50257795225295 0.959971451385367 GO:0022829 wide pore channel activity 4/1849 37/18639 0.108108108108108 1.08979287562305 0.507135855544413 0.965631322428119 GO:0042805 actinin binding 4/1849 37/18639 0.108108108108108 1.08979287562305 0.507135855544413 0.965631322428119 GO:0001671 ATPase activator activity 3/1849 27/18639 0.111111111111111 1.12006489994592 0.509918072173397 0.967885243576778 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/1849 27/18639 0.111111111111111 1.12006489994592 0.509918072173397 0.967885243576778 GO:0004659 prenyltransferase activity 2/1849 17/18639 0.117647058823529 1.18595107053097 0.513814756630482 0.970717114320613 GO:0005092 GDP-dissociation inhibitor activity 2/1849 17/18639 0.117647058823529 1.18595107053097 0.513814756630482 0.970717114320613 GO:0070403 NAD+ binding 2/1849 17/18639 0.117647058823529 1.18595107053097 0.513814756630482 0.970717114320613 GO:0030145 manganese ion binding 7/1849 68/18639 0.102941176470588 1.0377071867146 0.517945811547823 0.976997473184445 GO:0061980 regulatory RNA binding 6/1849 58/18639 0.103448275862069 1.04281904477723 0.520740386642928 0.980741225854722 GO:0016853 isomerase activity 18/1849 180/18639 0.1 1.00805840995133 0.522439147694325 0.982412745120851 GO:0016879 ligase activity, forming carbon-nitrogen bonds 5/1849 48/18639 0.104166666666667 1.0500608436993 0.52420715259728 0.984209088054737 GO:0005501 retinoid binding 4/1849 38/18639 0.105263157894737 1.06111411573824 0.528727887963888 0.988101037537451 GO:0019840 isoprenoid binding 4/1849 38/18639 0.105263157894737 1.06111411573824 0.528727887963888 0.988101037537451 GO:0042162 telomeric DNA binding 4/1849 38/18639 0.105263157894737 1.06111411573824 0.528727887963888 0.988101037537451 GO:0016835 carbon-oxygen lyase activity 8/1849 79/18639 0.10126582278481 1.02081864298868 0.530525313962294 0.989236345266289 GO:0016298 lipase activity 13/1849 130/18639 0.1 1.00805840995133 0.530969136600403 0.989236345266289 GO:0046966 nuclear thyroid hormone receptor binding 3/1849 28/18639 0.107142857142857 1.08006258209071 0.535088781669067 0.992331569067749 GO:0051019 mitogen-activated protein kinase binding 3/1849 28/18639 0.107142857142857 1.08006258209071 0.535088781669067 0.992331569067749 GO:0051393 alpha-actinin binding 3/1849 28/18639 0.107142857142857 1.08006258209071 0.535088781669067 0.992331569067749 GO:0070063 RNA polymerase binding 6/1849 59/18639 0.101694915254237 1.02514414571321 0.537964684688463 0.99596868981109 GO:0000900 mRNA regulatory element binding translation repressor activity 2/1849 18/18639 0.111111111111111 1.12006489994592 0.545274352885841 0.99596868981109 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/1849 18/18639 0.111111111111111 1.12006489994592 0.545274352885841 0.99596868981109 GO:0004706 JUN kinase kinase kinase activity 2/1849 18/18639 0.111111111111111 1.12006489994592 0.545274352885841 0.99596868981109 GO:0008409 5'-3' exonuclease activity 2/1849 18/18639 0.111111111111111 1.12006489994592 0.545274352885841 0.99596868981109 GO:0008525 phosphatidylcholine transporter activity 2/1849 18/18639 0.111111111111111 1.12006489994592 0.545274352885841 0.99596868981109 GO:0015172 acidic amino acid transmembrane transporter activity 2/1849 18/18639 0.111111111111111 1.12006489994592 0.545274352885841 0.99596868981109 GO:0015280 ligand-gated sodium channel activity 2/1849 18/18639 0.111111111111111 1.12006489994592 0.545274352885841 0.99596868981109 GO:0050811 GABA receptor binding 2/1849 18/18639 0.111111111111111 1.12006489994592 0.545274352885841 0.99596868981109 GO:1901611 phosphatidylglycerol binding 2/1849 18/18639 0.111111111111111 1.12006489994592 0.545274352885841 0.99596868981109 GO:0016782 transferase activity, transferring sulphur-containing groups 7/1849 70/18639 0.1 1.00805840995133 0.549619541312956 0.999999999453347 GO:0016776 phosphotransferase activity, phosphate group as acceptor 4/1849 39/18639 0.102564102564103 1.03390606148854 0.549845418693246 0.999999999453347 GO:0035250 UDP-galactosyltransferase activity 3/1849 29/18639 0.103448275862069 1.04281904477723 0.559507000942732 0.999999999453347 GO:0106222 lncRNA binding 3/1849 29/18639 0.103448275862069 1.04281904477723 0.559507000942732 0.999999999453347 GO:0033192 calmodulin-dependent protein phosphatase activity 8/1849 81/18639 0.0987654320987654 0.99561324439637 0.559815736840242 0.999999999453347 GO:0140791 histone H2AXS140 phosphatase activity 8/1849 81/18639 0.0987654320987654 0.99561324439637 0.559815736840242 0.999999999453347 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 8/1849 81/18639 0.0987654320987654 0.99561324439637 0.559815736840242 0.999999999453347 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 8/1849 81/18639 0.0987654320987654 0.99561324439637 0.559815736840242 0.999999999453347 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 8/1849 81/18639 0.0987654320987654 0.99561324439637 0.559815736840242 0.999999999453347 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 8/1849 81/18639 0.0987654320987654 0.99561324439637 0.559815736840242 0.999999999453347 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 8/1849 81/18639 0.0987654320987654 0.99561324439637 0.559815736840242 0.999999999453347 GO:1990439 MAP kinase serine/threonine phosphatase activity 8/1849 81/18639 0.0987654320987654 0.99561324439637 0.559815736840242 0.999999999453347 GO:0043022 ribosome binding 11/1849 112/18639 0.0982142857142857 0.99005736691648 0.560520571386571 0.999999999453347 GO:0003713 transcription coactivator activity 25/1849 256/18639 0.09765625 0.984432040968091 0.564258346635814 0.999999999453347 GO:0050997 quaternary ammonium group binding 4/1849 40/18639 0.1 1.00805840995133 0.570453460609981 0.999999999453347 GO:0019001 guanyl nucleotide binding 39/1849 400/18639 0.0975 0.982856949702542 0.570873925004175 0.999999999453347 GO:0032561 guanyl ribonucleotide binding 39/1849 400/18639 0.0975 0.982856949702542 0.570873925004175 0.999999999453347 GO:0019905 syntaxin binding 6/1849 61/18639 0.0983606557377049 0.991532862247205 0.571576129297886 0.999999999453347 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 8/1849 82/18639 0.0975609756097561 0.983471619464707 0.574162882887003 0.999999999453347 GO:0033549 MAP kinase phosphatase activity 8/1849 82/18639 0.0975609756097561 0.983471619464707 0.574162882887003 0.999999999453347 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/1849 19/18639 0.105263157894737 1.06111411573824 0.575280509175459 0.999999999453347 GO:0005520 insulin-like growth factor binding 2/1849 19/18639 0.105263157894737 1.06111411573824 0.575280509175459 0.999999999453347 GO:0008381 mechanosensitive monoatomic ion channel activity 2/1849 19/18639 0.105263157894737 1.06111411573824 0.575280509175459 0.999999999453347 GO:0016918 retinal binding 2/1849 19/18639 0.105263157894737 1.06111411573824 0.575280509175459 0.999999999453347 GO:0022840 leak channel activity 2/1849 19/18639 0.105263157894737 1.06111411573824 0.575280509175459 0.999999999453347 GO:0022842 narrow pore channel activity 2/1849 19/18639 0.105263157894737 1.06111411573824 0.575280509175459 0.999999999453347 GO:0046624 sphingolipid transporter activity 2/1849 19/18639 0.105263157894737 1.06111411573824 0.575280509175459 0.999999999453347 GO:0097001 ceramide binding 2/1849 19/18639 0.105263157894737 1.06111411573824 0.575280509175459 0.999999999453347 GO:0016830 carbon-carbon lyase activity 5/1849 51/18639 0.0980392156862745 0.988292558775809 0.579724254597631 0.999999999453347 GO:0042379 chemokine receptor binding 7/1849 72/18639 0.0972222222222222 0.980056787452677 0.580366874637971 0.999999999453347 GO:0001965 G-protein alpha-subunit binding 3/1849 30/18639 0.1 1.00805840995133 0.583132418995965 0.999999999453347 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/1849 30/18639 0.1 1.00805840995133 0.583132418995965 0.999999999453347 GO:0015215 nucleotide transmembrane transporter activity 3/1849 30/18639 0.1 1.00805840995133 0.583132418995965 0.999999999453347 GO:0016769 transferase activity, transferring nitrogenous groups 3/1849 30/18639 0.1 1.00805840995133 0.583132418995965 0.999999999453347 GO:0070566 adenylyltransferase activity 3/1849 30/18639 0.1 1.00805840995133 0.583132418995965 0.999999999453347 GO:0015179 L-amino acid transmembrane transporter activity 6/1849 62/18639 0.0967741935483871 0.975540396727089 0.587922379782206 0.999999999453347 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 8/1849 83/18639 0.0963855421686747 0.971622563808506 0.588292900491896 0.999999999453347 GO:0005254 chloride channel activity 8/1849 83/18639 0.0963855421686747 0.971622563808506 0.588292900491896 0.999999999453347 GO:0008135 translation factor activity, RNA binding 8/1849 83/18639 0.0963855421686747 0.971622563808506 0.588292900491896 0.999999999453347 GO:0003924 GTPase activity 32/1849 331/18639 0.0966767371601208 0.974557979409136 0.589020491699122 0.999999999453347 GO:0017018 myosin phosphatase activity 8/1849 84/18639 0.0952380952380952 0.960055628525071 0.602193362020908 0.999999999453347 GO:0180051 translation factor activity 8/1849 84/18639 0.0952380952380952 0.960055628525071 0.602193362020908 0.999999999453347 GO:0001972 retinoic acid binding 2/1849 20/18639 0.1 1.00805840995133 0.603811873089619 0.999999999453347 GO:0015464 acetylcholine receptor activity 2/1849 20/18639 0.1 1.00805840995133 0.603811873089619 0.999999999453347 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/1849 20/18639 0.1 1.00805840995133 0.603811873089619 0.999999999453347 GO:0030742 GTP-dependent protein binding 2/1849 20/18639 0.1 1.00805840995133 0.603811873089619 0.999999999453347 GO:0043024 ribosomal small subunit binding 2/1849 20/18639 0.1 1.00805840995133 0.603811873089619 0.999999999453347 GO:0140939 histone H4 methyltransferase activity 2/1849 20/18639 0.1 1.00805840995133 0.603811873089619 0.999999999453347 GO:1901682 sulfur compound transmembrane transporter activity 6/1849 63/18639 0.0952380952380952 0.960055628525071 0.603938568114964 0.999999999453347 GO:0000287 magnesium ion binding 22/1849 230/18639 0.0956521739130435 0.964229783431702 0.604567770694582 0.999999999453347 GO:0047499 calcium-independent phospholipase A2 activity 3/1849 31/18639 0.0967741935483871 0.975540396727089 0.605934339888296 0.999999999453347 GO:0015294 solute:monoatomic cation symporter activity 11/1849 116/18639 0.0948275862068965 0.955917457712463 0.608583924525673 0.999999999453347 GO:0008307 structural constituent of muscle 4/1849 42/18639 0.0952380952380952 0.960055628525071 0.610027581466649 0.999999999453347 GO:0003684 damaged DNA binding 7/1849 74/18639 0.0945945945945946 0.953568766170172 0.610059331053179 0.999999999453347 GO:0051018 protein kinase A binding 5/1849 53/18639 0.0943396226415094 0.95099849995408 0.614734896692211 0.999999999453347 GO:0016791 phosphatase activity 26/1849 273/18639 0.0952380952380952 0.960055628525071 0.617346121059378 0.999999999453347 GO:0019003 GDP binding 7/1849 75/18639 0.0933333333333333 0.94085451595457 0.624476304074679 0.999999999453347 GO:0008509 monoatomic anion transmembrane transporter activity 14/1849 149/18639 0.0939597315436242 0.947168975793191 0.625476282128643 0.999999999453347 GO:0001653 peptide receptor activity 12/1849 128/18639 0.09375 0.945054759329367 0.625570144017198 0.999999999453347 GO:0015106 bicarbonate transmembrane transporter activity 3/1849 32/18639 0.09375 0.945054759329367 0.627890746732061 0.999999999453347 GO:0047498 calcium-dependent phospholipase A2 activity 3/1849 32/18639 0.09375 0.945054759329367 0.627890746732061 0.999999999453347 GO:0051059 NF-kappaB binding 3/1849 32/18639 0.09375 0.945054759329367 0.627890746732061 0.999999999453347 GO:0070717 poly-purine tract binding 3/1849 32/18639 0.09375 0.945054759329367 0.627890746732061 0.999999999453347 GO:0005245 voltage-gated calcium channel activity 4/1849 43/18639 0.0930232558139535 0.937728753443093 0.628949230155284 0.999999999453347 GO:0070851 growth factor receptor binding 13/1849 139/18639 0.0935251798561151 0.942788440961671 0.630694111586562 0.999999999453347 GO:0005123 death receptor binding 2/1849 21/18639 0.0952380952380952 0.960055628525071 0.630865620425718 0.999999999453347 GO:0005248 voltage-gated sodium channel activity 2/1849 21/18639 0.0952380952380952 0.960055628525071 0.630865620425718 0.999999999453347 GO:0015125 bile acid transmembrane transporter activity 2/1849 21/18639 0.0952380952380952 0.960055628525071 0.630865620425718 0.999999999453347 GO:0015174 basic amino acid transmembrane transporter activity 2/1849 21/18639 0.0952380952380952 0.960055628525071 0.630865620425718 0.999999999453347 GO:0035613 RNA stem-loop binding 2/1849 21/18639 0.0952380952380952 0.960055628525071 0.630865620425718 0.999999999453347 GO:0019842 vitamin binding 14/1849 150/18639 0.0933333333333333 0.94085451595457 0.63559987044072 0.999999999453347 GO:0051536 iron-sulfur cluster binding 7/1849 76/18639 0.0921052631578947 0.928474851270957 0.638592020261309 0.999999999453347 GO:0030547 signaling receptor inhibitor activity 4/1849 44/18639 0.0909090909090909 0.916416736319386 0.647271895108612 0.999999999453347 GO:0043014 alpha-tubulin binding 4/1849 44/18639 0.0909090909090909 0.916416736319386 0.647271895108612 0.999999999453347 GO:0003796 lysozyme activity 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0004090 carbonyl reductase (NADPH) activity 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0005131 growth hormone receptor binding 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0005345 purine nucleobase transmembrane transporter activity 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0005522 profilin binding 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0005528 FK506 binding 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0008140 cAMP response element binding protein binding 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0008519 ammonium channel activity 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0015279 store-operated calcium channel activity 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0019531 oxalate transmembrane transporter activity 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0032052 bile acid binding 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0035374 chondroitin sulfate binding 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0042166 acetylcholine binding 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0042975 peroxisome proliferator activated receptor binding 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0043121 neurotrophin binding 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0043295 glutathione binding 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0045322 unmethylated CpG binding 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0051378 serotonin binding 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0070097 delta-catenin binding 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0070513 death domain binding 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0097177 mitochondrial ribosome binding 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0140940 histone H2A methyltransferase activity 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:1990259 histone H2AQ104 methyltransferase activity 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:1990763 arrestin family protein binding 1/1849 10/18639 0.1 1.00805840995133 0.648305668165231 0.999999999453347 GO:0003714 transcription corepressor activity 19/1849 204/18639 0.0931372549019608 0.938877930837018 0.649075809845542 0.999999999453347 GO:0015377 chloride:monoatomic cation symporter activity 2/1849 22/18639 0.0909090909090909 0.916416736319386 0.656453992775186 0.999999999453347 GO:0016881 acid-amino acid ligase activity 2/1849 22/18639 0.0909090909090909 0.916416736319386 0.656453992775186 0.999999999453347 GO:0050321 tau-protein kinase activity 2/1849 22/18639 0.0909090909090909 0.916416736319386 0.656453992775186 0.999999999453347 GO:0070034 telomerase RNA binding 2/1849 22/18639 0.0909090909090909 0.916416736319386 0.656453992775186 0.999999999453347 GO:0003774 cytoskeletal motor activity 14/1849 153/18639 0.0915032679738562 0.922406388190755 0.665116937673071 0.999999999453347 GO:0005179 hormone activity 12/1849 132/18639 0.0909090909090909 0.916416736319386 0.668130943584449 0.999999999453347 GO:0015081 sodium ion transmembrane transporter activity 15/1849 164/18639 0.0914634146341463 0.922004643248163 0.668697509938126 0.999999999453347 GO:0015020 glucuronosyltransferase activity 3/1849 34/18639 0.0882352941176471 0.889463302898228 0.669216976988052 0.999999999453347 GO:0051427 hormone receptor binding 3/1849 34/18639 0.0882352941176471 0.889463302898228 0.669216976988052 0.999999999453347 GO:0090482 vitamin transmembrane transporter activity 3/1849 34/18639 0.0882352941176471 0.889463302898228 0.669216976988052 0.999999999453347 GO:0008528 G protein-coupled peptide receptor activity 11/1849 122/18639 0.0901639344262295 0.908905123726605 0.675535149450381 0.999999999453347 GO:0005283 amino acid:sodium symporter activity 2/1849 23/18639 0.0869565217391304 0.876572530392456 0.680601339144769 0.999999999453347 GO:0008171 O-methyltransferase activity 2/1849 23/18639 0.0869565217391304 0.876572530392456 0.680601339144769 0.999999999453347 GO:0099186 structural constituent of postsynapse 2/1849 23/18639 0.0869565217391304 0.876572530392456 0.680601339144769 0.999999999453347 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0003953 NAD+ nucleosidase activity 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0005225 volume-sensitive anion channel activity 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0005536 D-glucose binding 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0008526 phosphatidylinositol transfer activity 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0015173 aromatic amino acid transmembrane transporter activity 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0015205 nucleobase transmembrane transporter activity 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0016594 glycine binding 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0032794 GTPase activating protein binding 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0034511 U3 snoRNA binding 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0047676 arachidonate-CoA ligase activity 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0140537 transcription regulator activator activity 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:1900750 oligopeptide binding 1/1849 11/18639 0.0909090909090909 0.916416736319386 0.683212685158225 0.999999999453347 GO:0004623 phospholipase A2 activity 3/1849 35/18639 0.0857142857142857 0.864050065672564 0.688578261663717 0.999999999453347 GO:0005343 organic acid:sodium symporter activity 3/1849 35/18639 0.0857142857142857 0.864050065672564 0.688578261663717 0.999999999453347 GO:0043015 gamma-tubulin binding 3/1849 35/18639 0.0857142857142857 0.864050065672564 0.688578261663717 0.999999999453347 GO:0061631 ubiquitin conjugating enzyme activity 3/1849 35/18639 0.0857142857142857 0.864050065672564 0.688578261663717 0.999999999453347 GO:0008194 UDP-glycosyltransferase activity 13/1849 145/18639 0.0896551724137931 0.903776505473602 0.690777358367136 0.999999999453347 GO:0098960 postsynaptic neurotransmitter receptor activity 6/1849 69/18639 0.0869565217391304 0.876572530392456 0.692384748631155 0.999999999453347 GO:0005525 GTP binding 35/1849 378/18639 0.0925925925925926 0.933387416621597 0.693088517054818 0.999999999453347 GO:0005315 phosphate transmembrane transporter activity 2/1849 24/18639 0.0833333333333333 0.840048674959438 0.703341595764795 0.999999999453347 GO:0015149 hexose transmembrane transporter activity 2/1849 24/18639 0.0833333333333333 0.840048674959438 0.703341595764795 0.999999999453347 GO:0055056 D-glucose transmembrane transporter activity 2/1849 24/18639 0.0833333333333333 0.840048674959438 0.703341595764795 0.999999999453347 GO:0015101 organic cation transmembrane transporter activity 7/1849 81/18639 0.0864197530864197 0.871161588846824 0.704362064926996 0.999999999453347 GO:0004033 aldo-keto reductase (NADPH) activity 3/1849 36/18639 0.0833333333333333 0.840048674959438 0.707075382355939 0.999999999453347 GO:0016409 palmitoyltransferase activity 3/1849 36/18639 0.0833333333333333 0.840048674959438 0.707075382355939 0.999999999453347 GO:0045505 dynein intermediate chain binding 3/1849 36/18639 0.0833333333333333 0.840048674959438 0.707075382355939 0.999999999453347 GO:0036002 pre-mRNA binding 5/1849 59/18639 0.0847457627118644 0.854286788094343 0.708775939477757 0.999999999453347 GO:0015085 calcium ion transmembrane transporter activity 13/1849 147/18639 0.0884353741496599 0.891480226487566 0.709458731296876 0.999999999453347 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0004000 adenosine deaminase activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0004032 aldose reductase (NADPH) activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0005247 voltage-gated chloride channel activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0005527 macrolide binding 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0015269 calcium-activated potassium channel activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0015368 calcium:monoatomic cation antiporter activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0016273 arginine N-methyltransferase activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0016274 protein-arginine N-methyltransferase activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0016801 hydrolase activity, acting on ether bonds 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0016803 ether hydrolase activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0016840 carbon-nitrogen lyase activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0031543 peptidyl-proline dioxygenase activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0035197 siRNA binding 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0035259 nuclear glucocorticoid receptor binding 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0035497 cAMP response element binding 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0036009 protein-glutamine N-methyltransferase activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0042301 phosphate ion binding 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0140900 chloride:bicarbonate antiporter activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:1990459 transferrin receptor binding 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:1990817 poly(A) RNA polymerase activity 1/1849 12/18639 0.0833333333333333 0.840048674959438 0.714656734178111 0.999999999453347 GO:0001221 transcription coregulator binding 10/1849 115/18639 0.0869565217391304 0.876572530392456 0.715492156563215 0.999999999453347 GO:0001098 basal transcription machinery binding 5/1849 60/18639 0.0833333333333333 0.840048674959438 0.72276310632458 0.999999999453347 GO:0001099 basal RNA polymerase II transcription machinery binding 5/1849 60/18639 0.0833333333333333 0.840048674959438 0.72276310632458 0.999999999453347 GO:0005251 delayed rectifier potassium channel activity 2/1849 25/18639 0.08 0.80644672796106 0.724716146330866 0.999999999453347 GO:0008483 transaminase activity 2/1849 25/18639 0.08 0.80644672796106 0.724716146330866 0.999999999453347 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/1849 25/18639 0.08 0.80644672796106 0.724716146330866 0.999999999453347 GO:0015645 fatty acid ligase activity 2/1849 25/18639 0.08 0.80644672796106 0.724716146330866 0.999999999453347 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 2/1849 25/18639 0.08 0.80644672796106 0.724716146330866 0.999999999453347 GO:0120515 fatty acid-CoA ligase activity 2/1849 25/18639 0.08 0.80644672796106 0.724716146330866 0.999999999453347 GO:0004175 endopeptidase activity 37/1849 405/18639 0.091358024691358 0.920942251066643 0.727204921743701 0.999999999453347 GO:0001222 transcription corepressor binding 4/1849 49/18639 0.0816326530612245 0.822904824450061 0.729628904369414 0.999999999453347 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0004465 lipoprotein lipase activity 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0005172 vascular endothelial growth factor receptor binding 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0008253 5'-nucleotidase activity 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0019104 DNA N-glycosylase activity 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0032396 inhibitory MHC class I receptor activity 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0046974 histone H3K9 methyltransferase activity 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0051011 microtubule minus-end binding 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0061459 L-arginine transmembrane transporter activity 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0071837 HMG box domain binding 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0097157 pre-mRNA intronic binding 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0140666 annealing activity 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0140852 histone ubiquitin ligase activity 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:1901338 catecholamine binding 1/1849 13/18639 0.0769230769230769 0.775429546116404 0.742981193216318 0.999999999453347 GO:0015605 organophosphate ester transmembrane transporter activity 4/1849 50/18639 0.08 0.80644672796106 0.744240424075187 0.999999999453347 GO:0004529 DNA exonuclease activity 2/1849 26/18639 0.0769230769230769 0.775429546116404 0.744772012062603 0.999999999453347 GO:0008157 protein phosphatase 1 binding 2/1849 26/18639 0.0769230769230769 0.775429546116404 0.744772012062603 0.999999999453347 GO:0015145 monosaccharide transmembrane transporter activity 2/1849 26/18639 0.0769230769230769 0.775429546116404 0.744772012062603 0.999999999453347 GO:0034237 protein kinase A regulatory subunit binding 2/1849 26/18639 0.0769230769230769 0.775429546116404 0.744772012062603 0.999999999453347 GO:0051139 metal cation:proton antiporter activity 2/1849 26/18639 0.0769230769230769 0.775429546116404 0.744772012062603 0.999999999453347 GO:0120014 phospholipid transfer activity 2/1849 26/18639 0.0769230769230769 0.775429546116404 0.744772012062603 0.999999999453347 GO:0140104 molecular carrier activity 22/1849 249/18639 0.0883534136546185 0.890654016824464 0.747985676344899 0.999999999453347 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 11/1849 130/18639 0.0846153846153846 0.852972500728044 0.753503071936894 0.999999999453347 GO:0031491 nucleosome binding 6/1849 74/18639 0.0810810810810811 0.817344656717291 0.755285106497639 0.999999999453347 GO:0003712 transcription coregulator activity 45/1849 495/18639 0.0909090909090909 0.916416736319386 0.755475968065566 0.999999999453347 GO:0003743 translation initiation factor activity 4/1849 51/18639 0.0784313725490196 0.790634047020647 0.758241800200936 0.999999999453347 GO:0016597 amino acid binding 4/1849 51/18639 0.0784313725490196 0.790634047020647 0.758241800200936 0.999999999453347 GO:0030544 Hsp70 protein binding 4/1849 51/18639 0.0784313725490196 0.790634047020647 0.758241800200936 0.999999999453347 GO:0005262 calcium channel activity 11/1849 131/18639 0.083969465648855 0.846461260264471 0.76228041708346 0.999999999453347 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/1849 27/18639 0.0740740740740741 0.746709933297278 0.763560327253739 0.999999999453347 GO:0005385 zinc ion transmembrane transporter activity 2/1849 27/18639 0.0740740740740741 0.746709933297278 0.763560327253739 0.999999999453347 GO:0008395 steroid hydroxylase activity 2/1849 27/18639 0.0740740740740741 0.746709933297278 0.763560327253739 0.999999999453347 GO:0016405 CoA-ligase activity 2/1849 27/18639 0.0740740740740741 0.746709933297278 0.763560327253739 0.999999999453347 GO:0004065 arylsulfatase activity 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:0005313 L-glutamate transmembrane transporter activity 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:0008191 metalloendopeptidase inhibitor activity 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:0008195 phosphatidate phosphatase activity 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:0008494 translation activator activity 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:0008559 ABC-type xenobiotic transporter activity 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:0015386 potassium:proton antiporter activity 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:0015926 glucosidase activity 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:0043176 amine binding 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:0046030 inositol trisphosphate phosphatase activity 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:0061665 SUMO ligase activity 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:0061783 peptidoglycan muralytic activity 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:0070742 C2H2 zinc finger domain binding 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:1901474 azole transmembrane transporter activity 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:1901612 cardiolipin binding 1/1849 14/18639 0.0714285714285714 0.720041721393804 0.768495408492976 0.999999999453347 GO:0008234 cysteine-type peptidase activity 16/1849 187/18639 0.0855614973262032 0.86250986947707 0.769091670675673 0.999999999453347 GO:0061791 GTPase motor activity 3/1849 40/18639 0.075 0.756043807463494 0.772653767642264 0.999999999453347 GO:0140662 ATP-dependent protein folding chaperone 3/1849 40/18639 0.075 0.756043807463494 0.772653767642264 0.999999999453347 GO:1990606 membrane scission GTPase motor activity 3/1849 40/18639 0.075 0.756043807463494 0.772653767642264 0.999999999453347 GO:0019789 SUMO transferase activity 2/1849 28/18639 0.0714285714285714 0.720041721393804 0.781135061529483 0.999999999453347 GO:0051119 sugar transmembrane transporter activity 2/1849 28/18639 0.0714285714285714 0.720041721393804 0.781135061529483 0.999999999453347 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 2/1849 28/18639 0.0714285714285714 0.720041721393804 0.781135061529483 0.999999999453347 GO:1901505 carbohydrate derivative transmembrane transporter activity 4/1849 53/18639 0.0754716981132075 0.760798799963264 0.784450376044623 0.999999999453347 GO:0120013 lipid transfer activity 5/1849 65/18639 0.0769230769230769 0.775429546116404 0.785431070390546 0.999999999453347 GO:0001727 lipid kinase activity 3/1849 41/18639 0.0731707317073171 0.73760371459853 0.787032561679204 0.999999999453347 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/1849 41/18639 0.0731707317073171 0.73760371459853 0.787032561679204 0.999999999453347 GO:0061650 ubiquitin-like protein conjugating enzyme activity 3/1849 41/18639 0.0731707317073171 0.73760371459853 0.787032561679204 0.999999999453347 GO:0140828 metal cation:monoatomic cation antiporter activity 3/1849 41/18639 0.0731707317073171 0.73760371459853 0.787032561679204 0.999999999453347 GO:0004467 long-chain fatty acid-CoA ligase activity 1/1849 15/18639 0.0666666666666667 0.67203893996755 0.791478065657888 0.999999999453347 GO:0004559 alpha-mannosidase activity 1/1849 15/18639 0.0666666666666667 0.67203893996755 0.791478065657888 0.999999999453347 GO:0008252 nucleotidase activity 1/1849 15/18639 0.0666666666666667 0.67203893996755 0.791478065657888 0.999999999453347 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/1849 15/18639 0.0666666666666667 0.67203893996755 0.791478065657888 0.999999999453347 GO:0030553 cGMP binding 1/1849 15/18639 0.0666666666666667 0.67203893996755 0.791478065657888 0.999999999453347 GO:0033130 acetylcholine receptor binding 1/1849 15/18639 0.0666666666666667 0.67203893996755 0.791478065657888 0.999999999453347 GO:0042809 nuclear vitamin D receptor binding 1/1849 15/18639 0.0666666666666667 0.67203893996755 0.791478065657888 0.999999999453347 GO:0140161 monocarboxylate:sodium symporter activity 1/1849 15/18639 0.0666666666666667 0.67203893996755 0.791478065657888 0.999999999453347 GO:0141050 histone H3K deacetylase activity 1/1849 15/18639 0.0666666666666667 0.67203893996755 0.791478065657888 0.999999999453347 GO:0141051 histone H4K deacetylase activity 1/1849 15/18639 0.0666666666666667 0.67203893996755 0.791478065657888 0.999999999453347 GO:0046873 metal ion transmembrane transporter activity 40/1849 450/18639 0.0888888888888889 0.896051919956733 0.792196164141149 0.999999999453347 GO:0001217 DNA-binding transcription repressor activity 24/1849 278/18639 0.0863309352517986 0.870266253195389 0.792784246044414 0.999999999453347 GO:0015293 symporter activity 12/1849 146/18639 0.0821917808219178 0.828541158864103 0.793354471604986 0.999999999453347 GO:0051287 NAD binding 4/1849 54/18639 0.0740740740740741 0.746709933297278 0.796679825478987 0.999999999453347 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 2/1849 29/18639 0.0689655172413793 0.695212696518155 0.797551954906279 0.999999999453347 GO:0005416 amino acid:monoatomic cation symporter activity 2/1849 29/18639 0.0689655172413793 0.695212696518155 0.797551954906279 0.999999999453347 GO:0097472 cyclin-dependent protein kinase activity 2/1849 29/18639 0.0689655172413793 0.695212696518155 0.797551954906279 0.999999999453347 GO:0019894 kinesin binding 3/1849 42/18639 0.0714285714285714 0.720041721393804 0.800648329387862 0.999999999453347 GO:0015370 solute:sodium symporter activity 6/1849 79/18639 0.0759493670886076 0.765613982241513 0.808227015444015 0.999999999453347 GO:0000062 fatty-acyl-CoA binding 1/1849 16/18639 0.0625 0.630036506219578 0.812180227202055 0.999999999453347 GO:0004708 MAP kinase kinase activity 1/1849 16/18639 0.0625 0.630036506219578 0.812180227202055 0.999999999453347 GO:0008142 oxysterol binding 1/1849 16/18639 0.0625 0.630036506219578 0.812180227202055 0.999999999453347 GO:0015378 sodium:chloride symporter activity 1/1849 16/18639 0.0625 0.630036506219578 0.812180227202055 0.999999999453347 GO:0015385 sodium:proton antiporter activity 1/1849 16/18639 0.0625 0.630036506219578 0.812180227202055 0.999999999453347 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/1849 16/18639 0.0625 0.630036506219578 0.812180227202055 0.999999999453347 GO:0030275 LRR domain binding 1/1849 16/18639 0.0625 0.630036506219578 0.812180227202055 0.999999999453347 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/1849 30/18639 0.0666666666666667 0.67203893996755 0.81286763604273 0.999999999453347 GO:0048019 receptor antagonist activity 2/1849 30/18639 0.0666666666666667 0.67203893996755 0.81286763604273 0.999999999453347 GO:0051721 protein phosphatase 2A binding 2/1849 30/18639 0.0666666666666667 0.67203893996755 0.81286763604273 0.999999999453347 GO:0098918 structural constituent of synapse 2/1849 30/18639 0.0666666666666667 0.67203893996755 0.81286763604273 0.999999999453347 GO:0004712 protein serine/threonine/tyrosine kinase activity 3/1849 43/18639 0.0697674418604651 0.70329656508232 0.813525761830305 0.999999999453347 GO:0004722 protein serine/threonine phosphatase activity 8/1849 103/18639 0.0776699029126214 0.782957988311709 0.813542582361835 0.999999999453347 GO:0005253 monoatomic anion channel activity 8/1849 103/18639 0.0776699029126214 0.782957988311709 0.813542582361835 0.999999999453347 GO:0008236 serine-type peptidase activity 16/1849 194/18639 0.0824742268041237 0.831388379341299 0.815706484653859 0.999999999453347 GO:0003777 microtubule motor activity 5/1849 68/18639 0.0735294117647059 0.741219419081857 0.817403606496805 0.999999999453347 GO:0005548 phospholipid transporter activity 5/1849 68/18639 0.0735294117647059 0.741219419081857 0.817403606496805 0.999999999453347 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 4/1849 56/18639 0.0714285714285714 0.720041721393804 0.819454686178348 0.999999999453347 GO:0001046 core promoter sequence-specific DNA binding 3/1849 44/18639 0.0681818181818182 0.68731255223954 0.825690678907502 0.999999999453347 GO:0001223 transcription coactivator binding 3/1849 44/18639 0.0681818181818182 0.68731255223954 0.825690678907502 0.999999999453347 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/1849 31/18639 0.0645161290322581 0.650360264484726 0.827138897846485 0.999999999453347 GO:0016411 acylglycerol O-acyltransferase activity 2/1849 31/18639 0.0645161290322581 0.650360264484726 0.827138897846485 0.999999999453347 GO:0016878 acid-thiol ligase activity 2/1849 31/18639 0.0645161290322581 0.650360264484726 0.827138897846485 0.999999999453347 GO:0070273 phosphatidylinositol-4-phosphate binding 2/1849 31/18639 0.0645161290322581 0.650360264484726 0.827138897846485 0.999999999453347 GO:0051213 dioxygenase activity 7/1849 93/18639 0.0752688172043011 0.758753641898847 0.827733649124097 0.999999999453347 GO:0031490 chromatin DNA binding 10/1849 128/18639 0.078125 0.787545632774473 0.828030292197563 0.999999999453347 GO:0015932 nucleobase-containing compound transmembrane transporter activity 4/1849 57/18639 0.0701754385964912 0.707409410492158 0.830029504872367 0.999999999453347 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/1849 17/18639 0.0588235294117647 0.592975535265485 0.830828069112778 0.999999999453347 GO:0004550 nucleoside diphosphate kinase activity 1/1849 17/18639 0.0588235294117647 0.592975535265485 0.830828069112778 0.999999999453347 GO:0008484 sulfuric ester hydrolase activity 1/1849 17/18639 0.0588235294117647 0.592975535265485 0.830828069112778 0.999999999453347 GO:0008569 minus-end-directed microtubule motor activity 1/1849 17/18639 0.0588235294117647 0.592975535265485 0.830828069112778 0.999999999453347 GO:0030548 acetylcholine receptor regulator activity 1/1849 17/18639 0.0588235294117647 0.592975535265485 0.830828069112778 0.999999999453347 GO:0032977 membrane insertase activity 1/1849 17/18639 0.0588235294117647 0.592975535265485 0.830828069112778 0.999999999453347 GO:0045236 CXCR chemokine receptor binding 1/1849 17/18639 0.0588235294117647 0.592975535265485 0.830828069112778 0.999999999453347 GO:0051787 misfolded protein binding 1/1849 17/18639 0.0588235294117647 0.592975535265485 0.830828069112778 0.999999999453347 GO:0070492 oligosaccharide binding 1/1849 17/18639 0.0588235294117647 0.592975535265485 0.830828069112778 0.999999999453347 GO:1901567 fatty acid derivative binding 1/1849 17/18639 0.0588235294117647 0.592975535265485 0.830828069112778 0.999999999453347 GO:0016410 N-acyltransferase activity 7/1849 94/18639 0.074468085106383 0.750681794644604 0.835871026145961 0.999999999453347 GO:0140303 intramembrane lipid transporter activity 3/1849 45/18639 0.0666666666666667 0.67203893996755 0.837169710174922 0.999999999453347 GO:0017171 serine hydrolase activity 16/1849 198/18639 0.0808080808080808 0.814592654506121 0.839067812837576 0.999999999453347 GO:0061630 ubiquitin protein ligase activity 30/1849 353/18639 0.084985835694051 0.856706863981296 0.839465691542943 0.999999999453347 GO:0030515 snoRNA binding 2/1849 32/18639 0.0625 0.630036506219578 0.840422107920779 0.999999999453347 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/1849 32/18639 0.0625 0.630036506219578 0.840422107920779 0.999999999453347 GO:0042910 xenobiotic transmembrane transporter activity 2/1849 32/18639 0.0625 0.630036506219578 0.840422107920779 0.999999999453347 GO:0140142 nucleocytoplasmic carrier activity 2/1849 32/18639 0.0625 0.630036506219578 0.840422107920779 0.999999999453347 GO:0008308 voltage-gated monoatomic anion channel activity 1/1849 18/18639 0.0555555555555556 0.560032449972958 0.847625346537892 0.999999999453347 GO:0015373 monoatomic anion:sodium symporter activity 1/1849 18/18639 0.0555555555555556 0.560032449972958 0.847625346537892 0.999999999453347 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/1849 18/18639 0.0555555555555556 0.560032449972958 0.847625346537892 0.999999999453347 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/1849 18/18639 0.0555555555555556 0.560032449972958 0.847625346537892 0.999999999453347 GO:0022851 GABA-gated chloride ion channel activity 1/1849 18/18639 0.0555555555555556 0.560032449972958 0.847625346537892 0.999999999453347 GO:0032393 MHC class I receptor activity 1/1849 18/18639 0.0555555555555556 0.560032449972958 0.847625346537892 0.999999999453347 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/1849 18/18639 0.0555555555555556 0.560032449972958 0.847625346537892 0.999999999453347 GO:0099602 neurotransmitter receptor regulator activity 1/1849 18/18639 0.0555555555555556 0.560032449972958 0.847625346537892 0.999999999453347 GO:0016407 acetyltransferase activity 7/1849 96/18639 0.0729166666666667 0.735042590589508 0.851226412871047 0.999999999453347 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2/1849 33/18639 0.0606060606060606 0.610944490879591 0.852772734249486 0.999999999453347 GO:0071889 14-3-3 protein binding 2/1849 33/18639 0.0606060606060606 0.610944490879591 0.852772734249486 0.999999999453347 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/1849 19/18639 0.0526315789473684 0.530557057869118 0.86275561528025 0.999999999453347 GO:0004890 GABA-A receptor activity 1/1849 19/18639 0.0526315789473684 0.530557057869118 0.86275561528025 0.999999999453347 GO:0005229 intracellularly calcium-gated chloride channel activity 1/1849 19/18639 0.0526315789473684 0.530557057869118 0.86275561528025 0.999999999453347 GO:0008574 plus-end-directed microtubule motor activity 1/1849 19/18639 0.0526315789473684 0.530557057869118 0.86275561528025 0.999999999453347 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/1849 19/18639 0.0526315789473684 0.530557057869118 0.86275561528025 0.999999999453347 GO:0022821 solute:potassium antiporter activity 1/1849 19/18639 0.0526315789473684 0.530557057869118 0.86275561528025 0.999999999453347 GO:0031420 alkali metal ion binding 1/1849 19/18639 0.0526315789473684 0.530557057869118 0.86275561528025 0.999999999453347 GO:0042577 lipid phosphatase activity 1/1849 19/18639 0.0526315789473684 0.530557057869118 0.86275561528025 0.999999999453347 GO:0046527 glucosyltransferase activity 1/1849 19/18639 0.0526315789473684 0.530557057869118 0.86275561528025 0.999999999453347 GO:0120227 acyl-CoA binding 1/1849 19/18639 0.0526315789473684 0.530557057869118 0.86275561528025 0.999999999453347 GO:0141147 intracellularly calcium-gated channel activity 1/1849 19/18639 0.0526315789473684 0.530557057869118 0.86275561528025 0.999999999453347 GO:0008376 acetylgalactosaminyltransferase activity 2/1849 34/18639 0.0588235294117647 0.592975535265485 0.864244969078326 0.999999999453347 GO:0016831 carboxy-lyase activity 2/1849 34/18639 0.0588235294117647 0.592975535265485 0.864244969078326 0.999999999453347 GO:0052866 phosphatidylinositol phosphate phosphatase activity 2/1849 34/18639 0.0588235294117647 0.592975535265485 0.864244969078326 0.999999999453347 GO:0061659 ubiquitin-like protein ligase activity 31/1849 372/18639 0.0833333333333333 0.840048674959438 0.870528864900265 0.999999999453347 GO:0016229 steroid dehydrogenase activity 2/1849 35/18639 0.0571428571428571 0.576033377115043 0.874891436194363 0.999999999453347 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/1849 20/18639 0.05 0.504029204975663 0.876384233290283 0.999999999453347 GO:0015095 magnesium ion transmembrane transporter activity 1/1849 20/18639 0.05 0.504029204975663 0.876384233290283 0.999999999453347 GO:0016004 phospholipase activator activity 1/1849 20/18639 0.05 0.504029204975663 0.876384233290283 0.999999999453347 GO:0030627 pre-mRNA 5'-splice site binding 1/1849 20/18639 0.05 0.504029204975663 0.876384233290283 0.999999999453347 GO:0052745 inositol phosphate phosphatase activity 1/1849 20/18639 0.05 0.504029204975663 0.876384233290283 0.999999999453347 GO:0140664 ATP-dependent DNA damage sensor activity 1/1849 20/18639 0.05 0.504029204975663 0.876384233290283 0.999999999453347 GO:0015631 tubulin binding 32/1849 385/18639 0.0831168831168831 0.837866730349153 0.87731433732573 0.999999999453347 GO:0022824 transmitter-gated monoatomic ion channel activity 4/1849 63/18639 0.0634920634920635 0.640037085683381 0.883129178846297 0.999999999453347 GO:0022835 transmitter-gated channel activity 4/1849 63/18639 0.0634920634920635 0.640037085683381 0.883129178846297 0.999999999453347 GO:0004190 aspartic-type endopeptidase activity 2/1849 36/18639 0.0555555555555556 0.560032449972958 0.884762968773094 0.999999999453347 GO:0048020 CCR chemokine receptor binding 3/1849 50/18639 0.06 0.604835045970795 0.885232613025108 0.999999999453347 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/1849 21/18639 0.0476190476190476 0.480027814262536 0.888660163933511 0.999999999453347 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/1849 21/18639 0.0476190476190476 0.480027814262536 0.888660163933511 0.999999999453347 GO:0010314 phosphatidylinositol-5-phosphate binding 1/1849 21/18639 0.0476190476190476 0.480027814262536 0.888660163933511 0.999999999453347 GO:0036122 BMP binding 1/1849 21/18639 0.0476190476190476 0.480027814262536 0.888660163933511 0.999999999453347 GO:0051428 peptide hormone receptor binding 1/1849 21/18639 0.0476190476190476 0.480027814262536 0.888660163933511 0.999999999453347 GO:0004536 DNA nuclease activity 4/1849 64/18639 0.0625 0.630036506219578 0.890414228783334 0.999999999453347 GO:0003724 RNA helicase activity 5/1849 77/18639 0.0649350649350649 0.654583383085276 0.890843527894275 0.999999999453347 GO:0005048 signal sequence binding 3/1849 51/18639 0.0588235294117647 0.592975535265485 0.893169538826619 0.999999999453347 GO:0140767 enzyme-substrate adaptor activity 10/1849 139/18639 0.0719424460431655 0.725221877662824 0.893556774459457 0.999999999453347 GO:0019213 deacetylase activity 2/1849 37/18639 0.0540540540540541 0.544896437811527 0.893908446685276 0.999999999453347 GO:0030280 structural constituent of skin epidermis 2/1849 37/18639 0.0540540540540541 0.544896437811527 0.893908446685276 0.999999999453347 GO:0070001 aspartic-type peptidase activity 2/1849 37/18639 0.0540540540540541 0.544896437811527 0.893908446685276 0.999999999453347 GO:0022832 voltage-gated channel activity 13/1849 175/18639 0.0742857142857143 0.748843390249556 0.895620933039317 0.999999999453347 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 21/1849 268/18639 0.0783582089552239 0.789896515260367 0.898129616263526 0.999999999453347 GO:0004407 histone deacetylase activity 1/1849 22/18639 0.0454545454545455 0.458208368159693 0.899717600655336 0.999999999453347 GO:0033558 protein lysine deacetylase activity 1/1849 22/18639 0.0454545454545455 0.458208368159693 0.899717600655336 0.999999999453347 GO:0034062 5'-3' RNA polymerase activity 1/1849 22/18639 0.0454545454545455 0.458208368159693 0.899717600655336 0.999999999453347 GO:0097747 RNA polymerase activity 1/1849 22/18639 0.0454545454545455 0.458208368159693 0.899717600655336 0.999999999453347 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 3/1849 52/18639 0.0576923076923077 0.581572159587303 0.900610021165689 0.999999999453347 GO:0008186 ATP-dependent activity, acting on RNA 5/1849 79/18639 0.0632911392405063 0.638011651867927 0.903184158571034 0.999999999453347 GO:0052689 carboxylic ester hydrolase activity 6/1849 92/18639 0.0652173913043478 0.657429397794342 0.90433662871867 0.999999999453347 GO:0035403 histone H3T6 kinase activity 19/1849 247/18639 0.0769230769230769 0.775429546116404 0.904612219051967 0.999999999453347 GO:0106310 protein serine kinase activity 29/1849 361/18639 0.0803324099722992 0.809797614642339 0.906305490804672 0.999999999453347 GO:0034212 protein N-acetyltransferase activity 3/1849 53/18639 0.0566037735849057 0.570599099972448 0.907579599872953 0.999999999453347 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 3/1849 53/18639 0.0566037735849057 0.570599099972448 0.907579599872953 0.999999999453347 GO:0000049 tRNA binding 5/1849 80/18639 0.0625 0.630036506219578 0.908885680138962 0.999999999453347 GO:0005212 structural constituent of eye lens 1/1849 23/18639 0.0434782608695652 0.438286265196228 0.909677430723998 0.999999999453347 GO:0016917 GABA receptor activity 1/1849 23/18639 0.0434782608695652 0.438286265196228 0.909677430723998 0.999999999453347 GO:0042171 lysophosphatidic acid acyltransferase activity 1/1849 23/18639 0.0434782608695652 0.438286265196228 0.909677430723998 0.999999999453347 GO:0071617 lysophospholipid acyltransferase activity 1/1849 23/18639 0.0434782608695652 0.438286265196228 0.909677430723998 0.999999999453347 GO:0140463 chromatin-protein adaptor activity 3/1849 54/18639 0.0555555555555556 0.560032449972958 0.914103116013775 0.999999999453347 GO:0015144 carbohydrate transmembrane transporter activity 2/1849 40/18639 0.05 0.504029204975663 0.917445965960098 0.999999999453347 GO:0004806 triacylglycerol lipase activity 1/1849 24/18639 0.0416666666666667 0.420024337479719 0.918648553983094 0.999999999453347 GO:0060229 lipase activator activity 1/1849 24/18639 0.0416666666666667 0.420024337479719 0.918648553983094 0.999999999453347 GO:0140612 DNA damage sensor activity 1/1849 24/18639 0.0416666666666667 0.420024337479719 0.918648553983094 0.999999999453347 GO:0008276 protein methyltransferase activity 6/1849 95/18639 0.0631578947368421 0.636668469442942 0.919430918181747 0.999999999453347 GO:0008374 O-acyltransferase activity 3/1849 55/18639 0.0545454545454545 0.549850041791632 0.920204650937292 0.999999999453347 GO:0008080 N-acetyltransferase activity 4/1849 69/18639 0.0579710144927536 0.584381686928304 0.921164029859803 0.999999999453347 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/1849 41/18639 0.0487804878048781 0.491735809732354 0.924133832846298 0.999999999453347 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 8/1849 122/18639 0.0655737704918033 0.661021908164803 0.926284031063728 0.999999999453347 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 8/1849 122/18639 0.0655737704918033 0.661021908164803 0.926284031063728 0.999999999453347 GO:0000030 mannosyltransferase activity 1/1849 25/18639 0.04 0.40322336398053 0.926729070968604 0.999999999453347 GO:0017056 structural constituent of nuclear pore 1/1849 25/18639 0.04 0.40322336398053 0.926729070968604 0.999999999453347 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/1849 25/18639 0.04 0.40322336398053 0.926729070968604 0.999999999453347 GO:0019707 protein-cysteine S-acyltransferase activity 1/1849 25/18639 0.04 0.40322336398053 0.926729070968604 0.999999999453347 GO:0047617 fatty acyl-CoA hydrolase activity 1/1849 25/18639 0.04 0.40322336398053 0.926729070968604 0.999999999453347 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 18/1849 243/18639 0.0740740740740741 0.746709933297278 0.928127652110358 0.999999999453347 GO:0015079 potassium ion transmembrane transporter activity 11/1849 160/18639 0.06875 0.693040156841536 0.92955523300988 0.999999999453347 GO:0004520 DNA endonuclease activity 2/1849 42/18639 0.0476190476190476 0.480027814262536 0.93030810801922 0.999999999453347 GO:0005244 voltage-gated monoatomic ion channel activity 12/1849 173/18639 0.069364161849711 0.69923126701826 0.932215841804148 0.999999999453347 GO:0004676 3-phosphoinositide-dependent protein kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:0004711 ribosomal protein S6 kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:0035175 histone H3S10 kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:0035979 histone H2AXS139 kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:0044022 histone H3S28 kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:0044023 histone H4S1 kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:0044024 histone H2AS1 kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:0044025 histone H2BS14 kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:0072354 histone H3T3 kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:0072371 histone H2AS121 kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:0072518 Rho-dependent protein serine/threonine kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:0140823 histone H2BS36 kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:0140855 histone H3S57 kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:0140995 histone H2A kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:0140997 histone H4 kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:0140998 histone H2B kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:1990244 histone H2AT120 kinase activity 18/1849 245/18639 0.073469387755102 0.740614342005055 0.933495651110296 0.999999999453347 GO:0005267 potassium channel activity 8/1849 124/18639 0.0645161290322581 0.650360264484726 0.933699224716956 0.999999999453347 GO:0005227 calcium-activated cation channel activity 1/1849 26/18639 0.0384615384615385 0.387714773058202 0.934007353324844 0.999999999453347 GO:0016289 acyl-CoA hydrolase activity 1/1849 26/18639 0.0384615384615385 0.387714773058202 0.934007353324844 0.999999999453347 GO:0004677 DNA-dependent protein kinase activity 18/1849 246/18639 0.0731707317073171 0.73760371459853 0.936050312786893 0.999999999453347 GO:0140857 histone H3T45 kinase activity 18/1849 246/18639 0.0731707317073171 0.73760371459853 0.936050312786893 0.999999999453347 GO:0035402 histone H3T11 kinase activity 18/1849 247/18639 0.0728744939271255 0.734617464741856 0.938521429325009 0.999999999453347 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 4/1849 73/18639 0.0547945205479452 0.552360772576069 0.93992867030516 0.999999999453347 GO:0005104 fibroblast growth factor receptor binding 1/1849 27/18639 0.037037037037037 0.373354966648639 0.940563008173732 0.999999999453347 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/1849 27/18639 0.037037037037037 0.373354966648639 0.940563008173732 0.999999999453347 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/1849 27/18639 0.037037037037037 0.373354966648639 0.940563008173732 0.999999999453347 GO:0004679 AMP-activated protein kinase activity 18/1849 248/18639 0.0725806451612903 0.731655297545317 0.940911000349267 0.999999999453347 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 3/1849 60/18639 0.05 0.504029204975663 0.94516730474346 0.999999999453347 GO:0051539 4 iron, 4 sulfur cluster binding 2/1849 45/18639 0.0444444444444444 0.448025959978367 0.946099170959906 0.999999999453347 GO:0005242 inward rectifier potassium channel activity 1/1849 28/18639 0.0357142857142857 0.360020860696902 0.946467746938334 0.999999999453347 GO:0051959 dynein light intermediate chain binding 1/1849 28/18639 0.0357142857142857 0.360020860696902 0.946467746938334 0.999999999453347 GO:0004842 ubiquitin-protein transferase activity 35/1849 449/18639 0.0779510022271715 0.785791633592347 0.949637173281194 0.999999999453347 GO:0008017 microtubule binding 20/1849 276/18639 0.072463768115942 0.730477108660381 0.950257514067516 0.999999999453347 GO:0004181 metallocarboxypeptidase activity 1/1849 29/18639 0.0344827586206897 0.347606348259078 0.951786168082336 0.999999999453347 GO:0016417 S-acyltransferase activity 1/1849 29/18639 0.0344827586206897 0.347606348259078 0.951786168082336 0.999999999453347 GO:0022843 voltage-gated monoatomic cation channel activity 9/1849 143/18639 0.0629370629370629 0.634442355913421 0.952610963400819 0.999999999453347 GO:0099095 ligand-gated monoatomic anion channel activity 2/1849 47/18639 0.0425531914893617 0.428961025511202 0.954664440427673 0.999999999453347 GO:0140359 ABC-type transporter activity 2/1849 47/18639 0.0425531914893617 0.428961025511202 0.954664440427673 0.999999999453347 GO:0140938 histone H3 methyltransferase activity 2/1849 47/18639 0.0425531914893617 0.428961025511202 0.954664440427673 0.999999999453347 GO:0022839 monoatomic ion-gated channel activity 1/1849 30/18639 0.0333333333333333 0.336019469983775 0.956576462290598 0.999999999453347 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 8/1849 132/18639 0.0606060606060606 0.610944490879591 0.957220062642026 0.999999999453347 GO:0032266 phosphatidylinositol-3-phosphate binding 2/1849 48/18639 0.0416666666666667 0.420024337479719 0.958442709380818 0.999999999453347 GO:0004674 protein serine/threonine kinase activity 33/1849 433/18639 0.0762124711316397 0.76826622467422 0.959567619581199 0.999999999453347 GO:0019787 ubiquitin-like protein transferase activity 37/1849 479/18639 0.0772442588726514 0.778667247770334 0.959850286852733 0.999999999453347 GO:0005184 neuropeptide hormone activity 1/1849 31/18639 0.032258064516129 0.325180132242363 0.960891047772069 0.999999999453347 GO:0008327 methyl-CpG binding 1/1849 31/18639 0.032258064516129 0.325180132242363 0.960891047772069 0.999999999453347 GO:0072349 modified amino acid transmembrane transporter activity 1/1849 31/18639 0.032258064516129 0.325180132242363 0.960891047772069 0.999999999453347 GO:0022836 gated channel activity 23/1849 318/18639 0.0723270440251572 0.729098849964795 0.961424236205952 0.999999999453347 GO:0160215 deacylase activity 3/1849 65/18639 0.0461538461538462 0.465257727669842 0.962703188423549 0.999999999453347 GO:0015276 ligand-gated monoatomic ion channel activity 12/1849 186/18639 0.0645161290322581 0.650360264484726 0.963463403259195 0.999999999453347 GO:0003823 antigen binding 11/1849 174/18639 0.0632183908045977 0.637278305141642 0.964561233707662 0.999999999453347 GO:0160041 neuropeptide activity 1/1849 32/18639 0.03125 0.315018253109789 0.964777142605981 0.999999999453347 GO:0016779 nucleotidyltransferase activity 8/1849 136/18639 0.0588235294117647 0.592975535265485 0.965909181175598 0.999999999453347 GO:0099094 ligand-gated monoatomic cation channel activity 8/1849 136/18639 0.0588235294117647 0.592975535265485 0.965909181175598 0.999999999453347 GO:0016755 aminoacyltransferase activity 38/1849 496/18639 0.0766129032258065 0.772302814075612 0.9663608684787 0.999999999453347 GO:0022834 ligand-gated channel activity 12/1849 188/18639 0.0638297872340425 0.643441538266803 0.966915237071566 0.999999999453347 GO:0004252 serine-type endopeptidase activity 11/1849 176/18639 0.0625 0.630036506219578 0.968022120436537 0.999999999453347 GO:0042054 histone methyltransferase activity 3/1849 67/18639 0.0447761194029851 0.451369437291638 0.968113291139714 0.999999999453347 GO:0019239 deaminase activity 1/1849 33/18639 0.0303030303030303 0.305472245439796 0.968277280367122 0.999999999453347 GO:0042923 neuropeptide binding 1/1849 33/18639 0.0303030303030303 0.305472245439796 0.968277280367122 0.999999999453347 GO:1990841 promoter-specific chromatin binding 3/1849 68/18639 0.0441176470588235 0.444731651449114 0.970531667279301 0.999999999453347 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/1849 34/18639 0.0294117647058824 0.296487767632743 0.9714297746486 0.999999999453347 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/1849 34/18639 0.0294117647058824 0.296487767632743 0.9714297746486 0.999999999453347 GO:0005249 voltage-gated potassium channel activity 5/1849 98/18639 0.0510204081632653 0.514315515281288 0.971542887843641 0.999999999453347 GO:0008170 N-methyltransferase activity 5/1849 98/18639 0.0510204081632653 0.514315515281288 0.971542887843641 0.999999999453347 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 15/1849 229/18639 0.0655021834061135 0.660300268527069 0.972046154127134 0.999999999453347 GO:0004527 exonuclease activity 4/1849 84/18639 0.0476190476190476 0.480027814262536 0.972482172453707 0.999999999453347 GO:0016279 protein-lysine N-methyltransferase activity 3/1849 69/18639 0.0434782608695652 0.438286265196228 0.972775650798369 0.999999999453347 GO:0016278 lysine N-methyltransferase activity 3/1849 70/18639 0.0428571428571429 0.432025032836282 0.974856890999407 0.999999999453347 GO:0050661 NADP binding 2/1849 54/18639 0.037037037037037 0.373354966648639 0.975498365907421 0.999999999453347 GO:0000993 RNA polymerase II complex binding 1/1849 36/18639 0.0277777777777778 0.280016224986479 0.976826456652062 0.999999999453347 GO:0004521 RNA endonuclease activity 3/1849 73/18639 0.0410958904109589 0.414270579432051 0.980230608053475 0.999999999453347 GO:0004497 monooxygenase activity 5/1849 106/18639 0.0471698113207547 0.47549924997704 0.983650001849694 0.999999999453347 GO:0016741 transferase activity, transferring one-carbon groups 13/1849 215/18639 0.0604651162790698 0.60952368973801 0.983990087358703 0.999999999453347 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1/1849 40/18639 0.025 0.252014602487831 0.98475529291704 0.999999999453347 GO:0071949 FAD binding 1/1849 40/18639 0.025 0.252014602487831 0.98475529291704 0.999999999453347 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 2/1849 60/18639 0.0333333333333333 0.336019469983775 0.985687889621678 0.999999999453347 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/1849 60/18639 0.0333333333333333 0.336019469983775 0.985687889621678 0.999999999453347 GO:0016887 ATP hydrolysis activity 29/1849 417/18639 0.0695443645083933 0.701047815074063 0.986815942691599 0.999999999453347 GO:0043175 RNA polymerase core enzyme binding 1/1849 42/18639 0.0238095238095238 0.240013907131268 0.987635773843189 0.999999999453347 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 10/1849 181/18639 0.0552486187845304 0.556938348039406 0.988166396253066 0.999999999453347 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/1849 43/18639 0.0232558139534884 0.234432188360773 0.988865082557709 0.999999999453347 GO:0004519 endonuclease activity 6/1849 127/18639 0.047244094488189 0.476248067693539 0.989482776966557 0.999999999453347 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/1849 46/18639 0.0217391304347826 0.219143132598114 0.991867356902484 0.999999999453347 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1/1849 46/18639 0.0217391304347826 0.219143132598114 0.991867356902484 0.999999999453347 GO:0061733 protein-lysine-acetyltransferase activity 1/1849 47/18639 0.0212765957446809 0.214480512755601 0.992676115956284 0.999999999453347 GO:0008188 neuropeptide receptor activity 1/1849 48/18639 0.0208333333333333 0.210012168739859 0.993404486308953 0.999999999453347 GO:0002039 p53 binding 2/1849 69/18639 0.0289855072463768 0.292190843464152 0.993700735006967 0.999999999453347 GO:0000510 H3-H4 histone complex chaperone activity 7/1849 151/18639 0.0463576158940397 0.4673118456728 0.994446354220295 0.999999999453347 GO:0140584 chromatin extrusion motor activity 7/1849 151/18639 0.0463576158940397 0.4673118456728 0.994446354220295 0.999999999453347 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 7/1849 151/18639 0.0463576158940397 0.4673118456728 0.994446354220295 0.999999999453347 GO:0140849 ATP-dependent H2AZ histone chaperone activity 7/1849 151/18639 0.0463576158940397 0.4673118456728 0.994446354220295 0.999999999453347 GO:0003730 mRNA 3'-UTR binding 15/1849 262/18639 0.0572519083969466 0.577132677453049 0.994699724182381 0.999999999453347 GO:0015616 DNA translocase activity 7/1849 152/18639 0.0460526315789474 0.464237425635479 0.994811014495631 0.999999999453347 GO:0140674 ATP-dependent histone chaperone activity 7/1849 152/18639 0.0460526315789474 0.464237425635479 0.994811014495631 0.999999999453347 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 8/1849 167/18639 0.0479041916167665 0.482902232312012 0.994966255693813 0.999999999453347 GO:0061775 cohesin loader activity 7/1849 153/18639 0.0457516339869281 0.461203194095377 0.99515283376849 0.999999999453347 GO:0140658 ATP-dependent chromatin remodeler activity 7/1849 158/18639 0.0443037974683544 0.446608156307549 0.996563860655623 0.999999999453347 GO:0003689 DNA clamp loader activity 7/1849 160/18639 0.04375 0.441025554353705 0.997010150341259 0.999999999453347 GO:0008168 methyltransferase activity 10/1849 204/18639 0.0490196078431373 0.494146279387904 0.997068378453669 0.999999999453347 GO:0042393 histone binding 13/1849 247/18639 0.0526315789473684 0.530557057869118 0.997274930592567 0.999999999453347 GO:0140713 histone chaperone activity 7/1849 164/18639 0.0426829268292683 0.43026883351581 0.997741977646201 0.999999999453347 GO:0004518 nuclease activity 10/1849 209/18639 0.0478468899521531 0.482324598062835 0.997866607456172 0.999999999453347 GO:0043130 ubiquitin binding 3/1849 100/18639 0.03 0.302417522985397 0.997948306670483 0.999999999453347 GO:0004540 RNA nuclease activity 4/1849 121/18639 0.0330578512396694 0.333242449570686 0.998462816136835 0.999999999453347 GO:0004386 helicase activity 6/1849 155/18639 0.0387096774193548 0.390216158690835 0.998592164514215 0.999999999453347 GO:0050660 flavin adenine dinucleotide binding 2/1849 86/18639 0.0232558139534884 0.234432188360773 0.998710032160825 0.999999999453347 GO:0140597 protein carrier chaperone 8/1849 188/18639 0.0425531914893617 0.428961025511202 0.998786131456996 0.999999999453347 GO:0140223 general transcription initiation factor activity 1/1849 68/18639 0.0147058823529412 0.148243883816371 0.999189319347584 0.999999999453347 GO:0008094 ATP-dependent activity, acting on DNA 9/1849 210/18639 0.0428571428571429 0.432025032836282 0.999247676563087 0.999999999453347 GO:0003678 DNA helicase activity 1/1849 74/18639 0.0135135135135135 0.136224109452882 0.999567955393813 0.999999999453347 GO:0035064 methylated histone binding 1/1849 74/18639 0.0135135135135135 0.136224109452882 0.999567955393813 0.999999999453347 GO:0032182 ubiquitin-like protein binding 3/1849 120/18639 0.025 0.252014602487831 0.999648487901009 0.999999999453347 GO:0140034 methylation-dependent protein binding 1/1849 76/18639 0.0131578947368421 0.13263926446728 0.999649731713598 0.999999999453347 GO:0019783 ubiquitin-like protein peptidase activity 3/1849 127/18639 0.0236220472440945 0.23812403384677 0.999812811683568 0.999999999453347 GO:0004843 cysteine-type deubiquitinase activity 2/1849 108/18639 0.0185185185185185 0.186677483324319 0.999842282478601 0.999999999453347 GO:0101005 deubiquitinase activity 2/1849 115/18639 0.0173913043478261 0.175314506078491 0.99991989303531 0.999999999453347 GO:0140097 catalytic activity, acting on DNA 15/1849 336/18639 0.0446428571428571 0.450026075871127 0.9999361080136 0.999999999453347 GO:0140030 modification-dependent protein binding 4/1849 173/18639 0.023121387283237 0.233077089006087 0.99998225537902 0.999999999453347 GO:0045182 translation regulator activity 14/1849 356/18639 0.0393258426966292 0.3964274645876 0.999994007971138 0.999999999453347 GO:0140101 catalytic activity, acting on a tRNA 1/1849 139/18639 0.00719424460431655 0.0725221877662824 0.99999953380801 0.999999999453347 GO:0140098 catalytic activity, acting on RNA 11/1849 387/18639 0.0284237726098191 0.286528230218723 0.999999986383555 0.999999999453347 GO:0030371 translation repressor activity 6/1849 329/18639 0.0182370820668693 0.183840439504801 0.999999999453347 0.999999999453347