category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	88/620	238/9376	5.59154242342098	F13A1/C1QA/C1QB/RPL27A/RPS23/C1QC/RPS18/RPL37/RPL37A/RPL23A/CCL2/RPS4X/RPL32/RPL35/RPL38/RPL36/RPL7A/RPL3/RPL14/RPL29/RPS27A/RPL23/RPS11/RPS12/RPL26/RPL15/RPLP1/JUN/CFD/RPS14/RPL10/IL6ST/C7/RPL27/RPL41/RPS24/RPS2/RPL11/RPS29/RPL10A/RPL30/NRP1/RPS27/RPS19/RPLP2/RPL13A/RPS15A/RPL19/RPS3/RPS21/RPS15/RPL9/RPL5/RPL24/RPL18/RPL18A/RPL39/RPL8/RPL36A/RPS28/RPL22/RPS25/RPL13/UBA52/RPS3A/RPS6/RPL34/RPL12/RPS7/RPL21/RPL35A/FOS/AGTR1/RPS5/C1R/RPS8/RPS10/RPL28/RPS16/RPS13/RPL6/RPL17/RPL7/RPLP0/MMP1/TLR7/C2/RPL22L1	19.0919421385866
Genetic Information Processing	Translation	hsa03010	Ribosome	76/620	222/9376	5.17709968032549	RPL27A/RPS23/RPS18/RPL37/RPL37A/RPL23A/RPS4X/RPL32/RPL35/RPL38/RPL36/RPL7A/RPL3/RPL14/RPL29/RPS27A/RPL23/RPS11/RPS12/RPL26/RPL15/RPLP1/RPS14/RPL10/RPL27/RPL41/RPS24/RPS2/RPL11/RPS29/RPL10A/RPL30/RPS27/RPS19/RPLP2/RPL13A/RPS15A/RPL19/RPS3/RPS21/RPS15/RPL9/RPL5/RPL24/RPL18/RPL18A/RPL39/RPL8/RPL36A/RPS28/RPL22/RPS25/RPL13/UBA52/RPS3A/RPS6/RPL34/RPL12/RPS7/RPL21/RACK1/RPL35A/RPS5/RPS8/RPS10/RPL28/RPS16/RPS13/RPL6/RPL17/RPL7/RPLP0/MRPL47/MRPS15/DAP3/RPL22L1	16.7600179284893
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	53/620	275/9376	2.91453372434018	MT-ND1/MT-ND3/MT-CYB/MT-ATP6/MT-CO2/MT-CO3/MT-ND4/MT-ND2/MT-CO1/C1QA/MT-ND5/C1QB/C1QC/RYR2/LAMC1/C7/MT-ND4L/COX4I2/TUBA1B/CREB3L1/NDUFA4L2/PSMD2/COX6C/CAV1/EGR1/PSMC1/UQCRC1/PSMD4/UQCRB/CSNK2B/NDUFA4/PSMB6/CSNK2A2/VDAC2/UQCRFS1/ITPR2/GRIN2C/UQCRC2/COX5A/COX7C/ATP5PB/CAV2/PRKACA/BAX/PSMB7/STIP1/MT-ND6/NDUFA7/ADRM1/VDAC1/KLC1/ATP5PO/SDHC	8.57459106466507
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	43/620	205/9376	3.17205350118017	MT-ND1/MT-ND3/MT-CYB/MT-ATP6/MT-CO2/MT-CO3/MT-ND4/MT-ND2/MT-CO1/COL3A1/MT-ND5/COL1A1/CD36/COL1A2/RYR2/MT-ND4L/COX4I2/NDUFA4L2/AGTR1/TBC1D4/COX6C/PLCB1/MMP2/UQCRC1/UQCRB/NDUFA4/VDAC2/UQCRFS1/UQCRC2/PPP1CA/COX5A/COX7C/ATP5PB/MT-ND6/PPP1CC/NDUFA7/VDAC1/ATP5PO/IRS1/SMAD2/SLC2A1/MPC2/SDHC	8.36696030772657
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	45/620	268/9376	2.5392392874338	MT-ND1/MT-ND3/MT-CYB/MT-ATP6/MT-CO2/MT-CO3/MT-ND4/MT-ND2/MT-CO1/MT-ND5/RPS27A/MT-ND4L/UBB/COX4I2/CALM2/UBA52/TUBA1B/GNAI1/NDUFA4L2/PSMD2/COX6C/PSMC1/UBE2G2/UQCRC1/PSMD4/UQCRB/NDUFA4/PSMB6/VDAC2/UQCRFS1/ITPR2/UQCRC2/COX5A/COX7C/ATP5PB/PRKACA/BAX/PSMB7/MT-ND6/NDUFA7/ADRM1/VDAC1/KLC1/ATP5PO/SDHC	6.80284588387555
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	48/620	308/9376	2.35676581483033	MT-ND1/MT-ND3/MT-CYB/MT-ATP6/MT-CO2/MT-CO3/MT-ND4/MT-ND2/MT-CO1/MT-ND5/MT-ND4L/COX4I2/TUBA1B/CREB3L1/NDUFA4L2/PSMD2/COX6C/PLCB1/BDNF/PSMC1/UQCRC1/PSMD4/UQCRB/NDUFA4/PSMB6/HTT/VDAC2/UQCRFS1/DNAH8/UQCRC2/COX5A/ATG101/POLR2E/COX7C/GRIA4/ATP5PB/BAX/PSMB7/MT-ND6/NDUFA7/ADRM1/VDAC1/KLC1/ATP5PO/HDAC1/POLR2B/SDHC/HDAC2	6.44248033459984
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	28/620	138/9376	3.06834969611968	MT-ND1/MT-ND3/MT-CYB/MT-ATP6/MT-CO2/MT-CO3/MT-ND4/MT-ND2/MT-CO1/MT-ND5/MT-ND4L/COX4I2/NDUFA4L2/COX6C/UQCRC1/PPA1/UQCRB/NDUFA4/UQCRFS1/UQCRC2/COX5A/COX7C/ATP5PB/MT-ND6/NDUFA7/ATP5PO/COX15/SDHC	6.51333082771189
NA	NA	hsa04518	Integrin signaling	29/620	154/9376	2.84775869291998	SPP1/COL1A1/LAMA2/FN1/HGF/COL1A2/COL6A2/COL6A1/LAMC1/COL4A1/IGF1/FREM1/VCAM1/PDGFRA/LAMA4/LAMC3/ACTB/COL4A2/CCND1/CCND2/PDGFC/FLT1/VTN/TNXB/LAMB2/COL6A3/ACTG1/KDR/PTK2	6.15207557782675
NA	NA	hsa04517	IgSF CAM signaling	44/620	299/9376	2.22539648289999	SLIT2/PTPRD/MAGI1/CADM3/ANK2/PMP22/NRP1/ROBO1/UNC5C/CD28/IL1RAPL1/MTSS1/NRCAM/ROBO2/KIRREL1/TUBA1B/ACTB/SLIT3/MAGI2/MPDZ/CLMP/TJP1/CD209/MYH10/LMO7/PARD3/CNTNAP2/SPTBN1/BAIAP2/NFASC/JAM3/WASL/SRGAP2/ACTG1/SPTAN1/IL1RAPL2/PTPRF/JAM2/NLGN4X/KDR/TRPC6/PTK2/DYNLL2/ARF6	5.73019844458609
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	36/620	233/9376	2.33653606534681	DCN/COL3A1/COL1A1/LAMA2/FN1/COL1A2/COL6A2/COL6A1/FBLN1/NEBL/COL4A1/COL5A1/ANK2/COL5A2/FBLN2/COL11A1/SGCE/ACTB/COL4A2/FHL1/MYH10/TNNT3/ELN/BGN/SPTBN1/VCAN/TPM1/COL6A3/CSRP2/SGCB/FHL2/TNNT1/ACTG1/SPTAN1/NID2/DAAM1	5.4972171088151
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	36/620	235/9376	2.31665065202471	MT-ND1/MT-ND3/MT-CYB/MT-ATP6/MT-CO2/MT-CO3/MT-ND4/MT-ND2/MT-CO1/MT-ND5/PRKG1/MT-ND4L/COX4I2/RPS6/ACTB/CREB3L1/NDUFA4L2/COX6C/UQCRC1/UQCRB/NDUFA4/UQCRFS1/UQCRC2/COX20/COX5A/COX7C/ATP5PB/PRKACA/SMARCE1/MT-ND6/NDUFA7/ATP5PO/ACTG1/COX15/SDHC/COX14	5.43921519869238
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	59/620	480/9376	1.85881720430108	MT-ND1/MT-ND3/MT-CYB/MT-ATP6/MT-CO2/MT-CO3/MT-ND4/MT-ND2/MT-CO1/MT-ND5/WNT2/RYR2/RPS27A/MT-ND4L/UBB/COX4I2/CALM2/UBA52/TUBA1B/NDUFA4L2/PSMD2/COX6C/PLCB1/BDNF/PSMC1/UBE2G2/UQCRC1/PSMD4/UQCRB/CSNK2B/NDUFA4/PSMB6/HTT/CSNK2A2/VDAC2/UQCRFS1/DNAH8/ITPR2/GRIN2C/UQCRC2/COX5A/ATG101/COX7C/GRIA4/ATP5PB/TARDBP/LRP6/BAX/PSMB7/CAT/MT-ND6/NDUFA7/FZD4/ADRM1/VDAC1/KLC1/ATP5PO/DVL3/SDHC	5.13987519785493
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	32/620	203/9376	2.38385507706976	SPP1/COL1A1/LAMA2/FN1/HGF/COL1A2/COL6A2/COL6A1/LAMC1/JUN/COL4A1/IGF1/PDGFRA/LAMA4/LAMC3/ACTB/COL4A2/CCND1/CCND2/PDGFC/FLT1/VTN/CAV1/TNXB/LAMB2/PPP1CA/CAV2/COL6A3/PPP1CC/ACTG1/KDR/PTK2	5.30409800616373
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	32/620	204/9376	2.37216951296648	DCN/LUM/COL1A1/GPC3/FN1/HGF/WNT2/COL1A2/TIMP3/IGF1/ANK2/TWIST1/IGF2/CD63/RPS6/ACTB/CCND1/VTN/CAV1/MMP2/ARHGEF12/ITPR2/PPP1CA/CAV2/PRKACA/EIF4B/PPP1CC/FZD4/ACTG1/SMAD2/KDR/PTK2	5.27253453539177
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	19/620	89/9376	3.22841609278724	SPP1/COL1A1/LAMA2/CD36/FN1/COL1A2/COL6A2/COL6A1/LAMC1/COL4A1/FREM1/LAMA4/LAMC3/COL4A2/VTN/TNXB/LAMB2/COL6A3/CD47	5.62059345278708
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	34/620	227/9376	2.26505613187438	MT-ND1/MT-ND3/MT-CYB/MT-ATP6/MT-CO2/MT-CO3/MT-ND4/MT-ND2/MT-CO1/MT-ND5/HGF/JUN/MT-ND4L/COX4I2/PRKD1/NDUFA4L2/FOS/COX6C/UQCRC1/UQCRB/NDUFA4/VDAC2/UQCRFS1/UQCRC2/COX5A/COX7C/ATP5PB/CAT/MT-ND6/NDUFA7/VDAC1/ATP5PO/PTK2/SDHC	5.13410229231229
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	48/620	388/9376	1.87083471898903	MT-ND1/MT-ND3/MT-CYB/MT-ATP6/MT-CO2/MT-CO3/MT-ND4/MT-ND2/MT-CO1/MT-ND5/WNT2/MT-ND4L/COX4I2/CALM2/TUBA1B/NDUFA4L2/PSMD2/COX6C/PLCB1/PSMC1/UQCRC1/PSMD4/UQCRB/CSNK2B/NDUFA4/PSMB6/CSNK2A2/VDAC2/UQCRFS1/ITPR2/GRIN2C/UQCRC2/COX5A/ATG101/COX7C/ATP5PB/LRP6/PSMB7/MT-ND6/NDUFA7/FZD4/ADRM1/VDAC1/KLC1/ATP5PO/IRS1/DVL3/SDHC	4.66174670861725
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	44/620	362/9376	1.83810372482623	SPP1/COL1A1/LAMA2/FN1/HGF/COL1A2/COL6A2/COL6A1/GNGT1/MAGI1/CSH1/LAMC1/GNG11/COL4A1/IGF1/PRLR/PDGFRA/LAMA4/ANGPT1/IGF2/LAMC3/RPS6/COL4A2/FGF7/KITLG/CREB3L1/MAGI2/CCND1/CCND2/PDGFC/FLT1/VTN/TNXB/BDNF/FGF10/LAMB2/GNG10/EIF4B/COL6A3/GNB2/IRS1/KDR/PTK2/GHR	4.32734863457068
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/620	101/9376	2.69511338230597	COL3A1/COL1A1/FN1/COL1A2/CCL2/JUN/COL4A1/VCAM1/COL4A2/CCND1/AGTR1/PLCB1/EGR1/MMP2/BAX/F3/PIM1/SMAD2	4.55754627271821
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	17/620	93/9376	2.76434269857787	PTPRM/ACTB/TJP1/LMO7/CDH5/PARD3/ARHGAP29/CSNK2B/CSNK2A2/PTPRB/BAIAP2/PDCD10/WASL/CTNNA2/ACTG1/PTPRF/SNAI2	4.54997332032264
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	43/620	368/9376	1.76704067321178	MT-ND1/MT-ND3/MT-CYB/MT-ATP6/MT-CO2/MT-CO3/MT-ND4/MT-ND2/MT-CO1/MT-ND5/MT-ND4L/COX4I2/TUBA1B/ACTB/NDUFA4L2/PSMD2/COX6C/PSMC1/UQCRC1/PSMD4/UQCRB/NDUFA4/PSMB6/UQCRFS1/DNAH8/GRIN2C/UQCRC2/COX5A/ATG101/COX7C/ATP5PB/TARDBP/BAX/PSMB7/CAT/MT-ND6/NDUFA7/ADRM1/VDAC1/KLC1/ATP5PO/ACTG1/SDHC	3.99444752863537
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	16/620	88/9376	2.74956011730205	F13A1/C1QA/C1QB/SERPINE2/C1QC/CFD/C7/PROS1/C4BPB/CR1/A2M/VTN/C1R/CD59/F3/C2	4.38770791395342
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	15/620	87/9376	2.60734149054505	MT-CYB/MT-CO2/MT-CO3/MT-CO1/RYR2/COX4I2/COX6C/UQCRC1/CACNA2D1/UQCRB/UQCRFS1/UQCRC2/COX5A/TPM1/COX7C	4.00785413166831
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	16/620	97/9376	2.49444629198537	PRKG1/GNGT1/RYR2/GNG11/CALM2/GUCY1A2/GUCY1A1/GNAI1/FOS/PLCB1/KCNJ5/GNG10/GRIN2C/GRIA4/PRKACA/GNB2	3.93680766931341
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	22/620	157/9376	2.11908773371687	MT-CYB/MT-CO2/MT-CO3/MT-CO1/JUN/COX4I2/NDUFA4L2/FOS/COX6C/UQCRC1/UQCRB/NDUFA4/UQCRFS1/UQCRC2/ADIPOR1/COX5A/COX7C/BAX/NDUFA7/IRS1/MLXIP/SDHC	3.76270924691946
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	21/620	149/9376	2.13137042649924	MT-ND1/MT-ND3/MT-ND4/MT-ND2/MT-ND5/GNGT1/GNG11/MT-ND4L/GNAI1/NDUFA4L2/PLCB1/KCNJ5/GABRA3/NDUFA4/ITPR2/GNG10/GRIA4/PRKACA/MT-ND6/NDUFA7/GNB2	3.70421599486085
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	20/620	140/9376	2.16036866359447	SPP1/GNGT1/RYR2/GNG11/MEF2C/CALM2/RPS6/GNAI1/CCN2/CCND1/AGTR1/PLCB1/EGR1/ITPR2/GNG10/APLN/PRKACA/GNB2/SMAD2/APLNR	3.68083757893524
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/620	103/9376	2.34913874099593	COL3A1/COL1A1/COL15A1/COL14A1/COL1A2/COL6A2/COL6A1/COL4A1/COL5A1/COL21A1/COL5A2/COL11A1/COL4A2/DPP4/ELN/COL6A3	3.66347896586556
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	16/620	103/9376	2.34913874099593	COL3A1/COL1A1/LAMA2/FN1/COL1A2/CD14/LAMC1/COL4A1/LAMA4/LAMC3/COL4A2/PLCB1/LAMB2/GNA14/PRKACA/PTK2	3.66347896586556
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	23/620	178/9376	1.95404131931859	WNT2/SERPINF1/RSPO2/JUN/PRICKLE1/NOTUM/RSPO3/MCC/CCND1/CCND2/ROR2/PLCB1/FRZB/NFATC2/CSNK2B/CSNK2A2/PRKACA/LRP6/FZD4/ROR1/DAAM1/DVL3/NKD1	3.41947229477793
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	18/620	130/9376	2.09389578163772	COL3A1/COL1A1/COL1A2/GNGT1/JUN/GNG11/COL4A1/COL4A2/GNAI1/CREB3L1/FOS/PLCB1/MMP2/GNG10/PRKACA/MMP1/GNB2/SMAD2	3.34194490348908
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	20/620	154/9376	1.96397151235861	RYR2/JUN/MEF2C/CALM2/GUCY1A2/ACTB/GUCY1A1/GNAI1/CCND1/FOS/PLCB1/NFATC2/CACNA2D1/KCNJ5/ITPR2/PPP1CA/PRKACA/PPP1CC/MAP2K5/ACTG1	3.20952385266843
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	12/620	78/9376	2.32655086848635	C1QA/C1QB/C1QC/CD14/JUN/C4BPB/CALM2/GNAI1/FOS/C1R/C2/TICAM2	3.130437556201
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/620	50/9376	2.72206451612903	HBA2/HBA1/HBB/CD36/HGF/CCL2/VCAM1/CR1/CD40	3.24874273349662
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	11/620	69/9376	2.41084618980832	JUN/CALM2/CREB3L1/FOS/GRIN2C/PPP1CA/GRIA4/PRKACA/PPP1CC/HDAC1/HDAC2	3.12988200049927
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/620	89/9376	2.20891627401232	PRKG1/GJA1/PDGFRA/TUBA1B/GUCY1A2/GUCY1A1/GNAI1/PDGFC/TJP1/PLCB1/ITPR2/PRKACA/MAP2K5	3.04917331941479
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	18/620	142/9376	1.91694684234439	CCL2/JUN/MEF2C/VCAM1/CALM2/BMP4/ACTB/FOS/CAV1/MMP2/CDH5/SUMO3/CAV2/MAP2K5/ACTG1/BMPR1A/KDR/PTK2	2.92969225441157
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	19/620	157/9376	1.83012122457366	BMP5/WNT2/YAP1/BMP4/ACTB/CCN2/CCND1/CCND2/PARD3/PPP1CA/CTNNA2/PPP1CC/FZD4/ACTG1/SMAD2/BMPR1A/DVL3/NKD1/SNAI2	2.79111700866669
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	20/620	170/9376	1.77912713472486	MAGI1/JUN/TUBA1B/ACTB/MPDZ/CCND1/TJP1/MYH10/GATA4/PARD3/JAM3/AMOTL2/PRKACA/CGNL1/ACTG1/RAB13/JAM2/SYMPK/HSPA4/AMOTL1	2.72788408296726
Organismal Systems	Immune system	hsa04611	Platelet activation	16/620	126/9376	1.92032770097286	COL3A1/COL1A1/PRKG1/COL1A2/GUCY1A2/ACTB/GUCY1A1/GNAI1/PLCB1/ARHGEF12/ITPR2/PPP1CA/PRKACA/PPP1CC/PTGS1/ACTG1	2.76748647273367
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	19/620	166/9376	1.73089778468714	PRKG1/PDE3A/MEF2C/CALM2/GUCY1A2/GUCY1A1/GNAI1/CREB3L1/AGTR1/PLCB1/NFATC2/GATA4/VDAC2/ITPR2/PPP1CA/PPP1CC/VDAC1/IRS1/TRPC6	2.52818867154801
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	12/620	93/9376	1.95130072840791	LAMA2/FN1/LAMC1/COL4A1/RARB/LAMA4/LAMC3/COL4A2/CCND1/LAMB2/BAX/PTK2	2.45326088709882
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	13/620	110/9376	1.78721407624633	DCN/BMP5/PITX2/BMP4/FMOD/THSD4/IGSF1/LTBP1/HDAC1/SMAD2/BMPR1A/FST/HDAC2	2.2098950661713
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	15/620	133/9376	1.7055542081009	GNGT1/GNG11/CALM2/GNAI1/CREB3L1/FOS/PLCB1/KCNJ5/ITPR2/GNG10/PPP1CA/GRIA4/PRKACA/PPP1CC/GNB2	2.18061169479445
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	7/620	46/9376	2.30126227208976	PSMD2/PSMC1/PSMD4/PSMB6/PSMB7/PSME3/ADRM1	2.35413594626394
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	15/620	134/9376	1.69282619162253	PRKG1/CALD1/CALM2/GUCY1A2/PLA2G2A/GUCY1A1/AGTR1/PLCB1/MYH10/ARHGEF12/ITPR2/PPP1CA/PRKACA/PPP1CC/RAMP2	2.14942512440646
NA	NA	hsa04081	Hormone signaling	22/620	219/9376	1.51916335248196	PRKG1/GNGT1/SLC40A1/CSH1/GNG11/IGF1/PRLR/CGA/IGF2/GNAI1/AGTR1/VIPR2/PLCB1/GNG10/ADIPOR1/GNA14/PRKACA/GNB2/IRS1/BMPR1A/RAMP2/GHR	2.06860745284605
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/620	37/9376	2.45231037489102	HBA2/HBA1/HBB/VCAM1/LAMA4/PLCB1	2.35525926394655
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	31/620	333/9376	1.40780780780781	SPP1/COL1A1/LAMA2/FN1/WNT2/COL1A2/COL6A2/RBPJ/COL6A1/MAGI1/LAMC1/COL4A1/LAMA4/LAMC3/COL4A2/CREB3L1/CCND1/CCND2/VTN/TNXB/PSMC1/LAMB2/PARD3/PRKACA/BAX/COL6A3/FZD4/HDAC1/DVL3/PTK2/HDAC2	2.01627606307155
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	19/620	184/9376	1.56157082748948	SLIT2/EPHA3/NRP1/ROBO1/UNC5C/ROBO2/ENAH/GNAI1/SLIT3/SEMA6D/NFATC2/PARD3/ARHGEF12/ABLIM3/EPHA5/SRGAP2/TRPC1/TRPC6/PTK2	2.04709052956417
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/620	160/9376	1.60677419354839	PTPRD/CADM3/VCAM1/CD28/PTPRM/NRCAM/CD34/CDH5/CNTNAP2/VCAN/NFASC/JAM3/PTPRF/CD40/JAM2/NLGN4X/CD4	2.05989207385062
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/620	69/9376	1.97251051893408	PDE3A/CALM2/GUCY1A2/GUCY1A1/GNAI1/AGTR1/PLCB1/ITPR2/PRKACA	2.15745925423772
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/620	70/9376	1.94433179723502	LAMA2/CD28/SGCE/ACTB/CCND1/CAV1/SGCB/ACTG1/CD40	2.11018589493133
NA	NA	hsa04519	Cadherin signaling	36/620	404/9376	1.34755669115299	CDH11/WNT2/GJA1/PRICKLE1/PCDH10/PDGFRA/YAP1/ENAH/KRT18/ACTB/KRT19/MPDZ/PCDH12/KRT7/TJP1/PCDH18/CDH5/GABRA3/KRT1/PPP1CA/KRT8/AMOTL2/CTNNA2/LRP6/SCN1B/MYO1B/FAT4/PPP1CC/FZD4/ACTG1/DAAM1/DVL3/KDR/PTK2/AMOTL1/NCKAP1	1.90020436136862
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	21/620	212/9376	1.49799147900183	HGF/MAGI1/IGF1/PDGFRA/ANGPT1/CALM2/ENAH/ACTB/FGF7/GNAI1/KITLG/MAGI2/PRKD1/PDGFC/FLT1/PLCB1/FGF10/PARD3/MAGI3/ACTG1/KDR	1.95153304012372
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	20/620	201/9376	1.50473439255336	IGFBP3/MAF/CD14/RUNX1T1/MEF2C/IGF1/PROM1/TSPAN7/HPGD/CCND2/FLT1/BAX/FCGR1A/HDAC1/CD40/ELK4/MLLT3/MEIS1/PTK2/HDAC2	1.92480393244297
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	13/620	117/9376	1.68028673835125	ACTB/BAZ2A/YY1/MTA3/RBBP4/SMARCE1/BRD7/HDAC1/ACTG1/SMARCA1/ZNHIT1/POLE3/HDAC2	1.97029611107895
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	15/620	144/9376	1.5752688172043	RBPJ/PSMD2/PLCB1/PSMC1/PSMD4/PSMB6/VDAC2/ITPR2/GRIN2C/RORA/ATG101/PSMB7/ADRM1/VDAC1/OPA1	1.85111239185421
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	13/620	122/9376	1.61142252776309	IGFBP3/CSH1/IGF1/GNAI1/CREB3L1/FOS/PLCB1/ITPR2/PRKACA/IRS1/PTK2/GHR/SOCS2	1.80877776412226
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	10/620	90/9376	1.68028673835125	IGF1/CREB3L1/ADIPOR1/ATG101/PRKACA/BAX/KL/CAT/EHMT1/IRS1	1.7255499139002
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	7/620	56/9376	1.89032258064516	DISP1/CCND1/CCND2/GLI3/PRKACA/CDON/CSNK1G3	1.77812403367939
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	14/620	139/9376	1.52313761893711	JUN/CALM2/KRT18/KRT19/GNAI1/CREB3L1/FOS/PLCB1/MMP2/KCNJ5/ITPR2/PRKACA/EBAG9/FKBP4	1.65343256195405
Human Diseases	Substance dependence	hsa05032	Morphine addiction	10/620	91/9376	1.66182204891882	GNGT1/PDE3A/GNG11/GNAI1/PDE4D/KCNJ5/GABRA3/GNG10/PRKACA/GNB2	1.6881054827839
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	12/620	115/9376	1.57800841514727	MEF2C/NACA/GNAI1/CREB3L1/FOS/PLCB1/PDE4D/EGR1/ITPR2/PRKACA/LRP6/KL	1.65952097488274
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/620	46/9376	1.97251051893408	BLVRB/FTL/ALAS2/GUSB/BLVRA/COX15	1.75938549810241
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/620	60/9376	1.76430107526882	PRKG1/IGF1/GUCY1A2/GUCY1A1/GNAI1/PLCB1/ITPR2	1.58035248014811
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/620	49/9376	1.85174456879526	JUN/GNAI1/CREB3L1/BDNF/GRIN2C/PRKACA	1.59061484399796
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	20/620	224/9376	1.35023041474654	JUN/NRP1/CREB3L1/CCND1/CCND2/FOS/EGR1/NFATC2/VDAC2/ANAPC5/PRKACA/BAX/VDAC1/XPO1/SMAD2/CD40/SLC2A1/ELK4/MAP3K3/CD4	1.41171967792662
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	11/620	109/9376	1.52613199171352	CD36/CREB3L1/TBC1D4/SLC27A4/PPP1CA/NR1H2/PPP1CC/IRS1/PTPRF/MLXIP/SLC2A1	1.47016806256622
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/620	73/9376	1.6572691117985	HGF/IGF1/PDGFRA/FGF7/CCND1/PDGFC/FGF10/BAX	1.50010531319915
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/620	86/9376	1.58259564891223	LAMA2/RYR2/GJA1/SGCE/ACTB/CACNA2D1/CTNNA2/SGCB/ACTG1	1.44423282620752
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/620	138/9376	1.42459093034128	FN1/CCL2/JUN/ACTB/FOS/NFATC2/ARHGEF12/BAIAP2/WASL/ACTG1/CD4/PTK2/ARF6	1.33705688208669
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/620	52/9376	1.74491315136476	PLTP/CD36/VDAC2/LRPAP1/VDAC1/NPC2	1.43329236574286
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/620	30/9376	2.01634408602151	IDH2/SUCLA2/IDH3B/SDHC	1.48360097450378
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/620	65/9376	1.62858560794045	SPP1/CGA/KISS1/PLCB1/KCNJ5/ITPR2/TRPC1	1.35316748826959
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/620	10/9376	3.02451612903226	SELENBP1/PAPSS1	1.70440488733795
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	11/620	115/9376	1.44650771388499	GNGT1/GNG11/GNAI1/PLCB1/KCNJ5/ITPR2/GNG10/PRKACA/TRPC1/PTGS1/GNB2	1.28196908076208
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/620	90/9376	1.51225806451613	JUN/CD28/FOS/NFATC2/CSNK2B/CSNK2A2/TICAM2/MAP3K3/CD4	1.29934454001379
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/620	78/9376	1.55103391232423	FN1/ACTB/CAV1/CAV2/WASL/CTNNA2/ACTG1/PTK2	1.30034761188496
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/620	103/9376	1.46821171312246	C1QA/C1QB/C1QC/CCL2/JUN/GNAI1/FOS/PLCB1/GNA14/SMAD2	1.27139167416524
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/620	116/9376	1.43403781979978	VCAM1/ACTB/GNAI1/MMP2/CDH5/JAM3/CTNNA2/ACTG1/JAM2/THY1/PTK2	1.25164071240076
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/620	116/9376	1.43403781979978	GNGT1/GNG11/GNAI1/PLCB1/ITPR2/GNG10/GRIN2C/GRIA4/PRKACA/TRPC1/GNB2	1.25164071240076
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/620	31/9376	1.95130072840791	SRP14/SRP72/OXA1L/SRPRA	1.41168444658857
NA	NA	hsa04981	Folate transport and metabolism	4/620	31/9376	1.95130072840791	FOLR2/ABCG2/SLCO2B1/MTHFR	1.41168444658857
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/620	67/9376	1.57997111218103	CALM2/PLCB1/ITPR2/GRIN2C/PPP1CA/PRKACA/PPP1CC	1.2677127404816
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/620	105/9376	1.44024577572965	CD14/EDA/VCAM1/CCL4L2/CCL4/CCL13/CSNK2B/CSNK2A2/TICAM2/CD40	1.2071331122372
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	10/620	105/9376	1.44024577572965	RPS27A/JUN/UBB/UBA52/PHB2/TOMM7/CSNK2B/CSNK2A2/TOMM20/OPA1	1.2071331122372
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/620	105/9376	1.44024577572965	LAMA2/RYR2/IGF1/SGCE/ACTB/CACNA2D1/TPM1/PRKACA/SGCB/ACTG1	1.2071331122372
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/620	80/9376	1.51225806451613	HGF/IGF1/PDGFRA/RPS6/PDGFC/GAS6/BAX/KDR	1.22437469944752
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/620	32/9376	1.89032258064516	ACSS1/ACSS3/SUCLA2/BCKDHA	1.34240811549099
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	20/620	238/9376	1.27080509623204	HGF/GNGT1/GNG11/IGF1/PDGFRA/ANGPT1/IGF2/CALM2/FGF7/PLA2G2A/KITLG/PDGFC/FLT1/BDNF/FGF10/GNG10/PRKACA/GNB2/KDR/ARF6	1.12602579946204
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/620	93/9376	1.46347554630593	JUN/CGA/CALM2/PLCB1/EGR1/MMP2/ITPR2/PRKACA/MAP3K3	1.19523342716453
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/620	56/9376	1.62027649769585	CD14/CR1/EEF1A1/HSF1/EEF1G/RAB1B	1.2387965576255
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	21/620	254/9376	1.2502921005842	HGF/RYR2/PDGFRA/CALM2/FGF7/PDGFC/AGTR1/FLT1/PLCB1/FGF10/NFATC2/VDAC2/ITPR2/GRIN2C/GNA14/PRKACA/PTGFR/TPCN1/VDAC1/KDR/PHKG2	1.07608746881621
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	19/620	227/9376	1.2657666619298	CCL2/GNGT1/GNG11/PDGFRA/CALM2/CCL4L2/CCL4/GNAI1/CREB3L1/CCND1/PLCB1/NFATC2/ARHGEF12/ITPR2/GNG10/PRKACA/BAX/GNB2/PTK2	1.07858710286024
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/620	83/9376	1.45759813447338	CSNK2B/YY1/KDM2B/HCFC1/RBBP4/FOXK1/HDAC1/HDAC2	1.11422764469782
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	11/620	122/9376	1.36351136964569	BMP4/ACTB/CCND1/TBC1D4/PLCB1/GATA4/PRKACA/HDAC1/ACTG1/SLC2A1/HDAC2	1.07537954943577
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/620	71/9376	1.49095865515675	PRLR/CGA/CCND1/CCND2/FOS/SOCS6/SOCS2	1.1049547998097
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/620	59/9376	1.53788955713505	PRKG1/CGA/GNAI1/PRKACA/PTGS1/IRS1	1.10283280784843
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	9/620	99/9376	1.37478005865103	JUN/IGF1/CCND1/FOS/MMP2/PRKACA/BAX/CARM1/PTK2	0.997513771815671
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	9/620	99/9376	1.37478005865103	C1QA/C1QB/C1QC/CFD/KRT18/KRT19/C1R/FCGR1A/C2	0.997513771815671
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	9/620	99/9376	1.37478005865103	LAMA2/RYR2/IGF1/SGCE/ACTB/CACNA2D1/TPM1/SGCB/ACTG1	0.997513771815671
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/620	36/9376	1.68028673835125	GUSB/KL/DCXR/AKR1B1	1.08817419692807
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	14/620	168/9376	1.26021505376344	CSH1/IL12RB2/IL6ST/PRLR/PDGFRA/CCND1/CCND2/FHL1/SOCS6/PIM1/LIFR/IL21R/GHR/SOCS2	0.905592901175108
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	9/620	101/9376	1.34755669115299	WNT2/CALM2/GNAI1/KITLG/CREB3L1/PLCB1/PRKACA/FZD4/DVL3	0.934454130830908
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	16/620	196/9376	1.23449637919684	GNGT1/RPS27A/JUN/GNG11/IL6ST/UBB/CALM2/UBA52/CCND1/FOS/NFATC2/CD200R1/ITPR2/GNG10/BAX/GNB2	0.882818535273431
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/620	62/9376	1.46347554630593	IGF1/PRKACA/CAT/HDAC1/IRS1/HDAC2	0.974278591232706
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	10/620	115/9376	1.31500701262272	GNGT1/GNG11/GNAI1/CREB3L1/FOS/PLCB1/ITPR2/GNG10/PRKACA/GNB2	0.904417186641424
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/620	89/9376	1.35933309169989	GNGT1/GNG11/GNAI1/GABRA3/GNG10/PRKACA/GNB2/SLC12A5	0.90632320827122
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/620	76/9376	1.39286926994907	CALM2/ACTB/GNAI1/PLCB1/ITPR2/PRKACA/ACTG1	0.91504402217066
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/620	63/9376	1.44024577572965	PTGDS/HPGDS/HPGD/PLA2G2A/PTGES3/PTGS1	0.932930469247736
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/620	63/9376	1.44024577572965	WNT2/BMP4/GLI3/BAX/FZD4/DVL3	0.932930469247736
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	13/620	157/9376	1.25218820628724	C1QA/CD36/C1QB/C1QC/PROS1/GAS6/NFATC2/UQCRFS1/RAB14/NR1H2/CD47/SLC2A1/PTK2	0.847932532161154
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	13/620	157/9376	1.25218820628724	IGFBP3/CALM2/CCND1/CCND2/NFATC2/GATA4/VDAC2/ITPR2/PPP1CA/RBBP4/PPP1CC/VDAC1/SMAD2	0.847932532161154
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	9/620	103/9376	1.32139054181021	DDX39B/RNPS1/PPP1CA/TARDBP/PPP1CC/DAZAP1/CSTF3/SYMPK/NCBP2	0.872710458881851
Genetic Information Processing	Transcription	hsa03040	Spliceosome	19/620	243/9376	1.18242400106199	SF3B2/PRPF8/DDX39B/CCDC12/SART1/TCERG1/THOC7/SRSF10/PRPF6/ZMAT2/SRSF1/SNRNP200/PRPF40B/CDC5L/RBM17/TXNL4A/PQBP1/NCBP2/SF3B5	0.766667390359109
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	6/620	66/9376	1.37478005865103	MAF/JUN/IL12RB2/RORA/SMAD2/IL21R	0.813021833480849
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	18/620	232/9376	1.17330367074527	TMSB4X/FN1/C7/PDGFRA/ENAH/ACTB/FGF7/PDGFC/MYH10/FGF10/ARHGEF12/PPP1CA/BAIAP2/WASL/PPP1CC/ACTG1/PTK2/NCKAP1	0.711233577939154
Human Diseases	Substance dependence	hsa05034	Alcoholism	15/620	191/9376	1.18763722344199	GNGT1/GNG11/HDAC9/CALM2/GNAI1/CREB3L1/BDNF/GNG10/GRIN2C/PPP1CA/PRKACA/PPP1CC/GNB2/HDAC1/HDAC2	0.697147553541224
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	9/620	108/9376	1.26021505376344	EEF1A1/SUMO3/DDX39B/RNPS1/THOC7/XPO1/NCBP2/XPO4/RANGAP1	0.723735522255445
Human Diseases	Infectious disease: viral	hsa05162	Measles	11/620	136/9376	1.22314990512334	JUN/CD28/RACK1/CCND1/CCND2/FOS/CD209/CSNK2B/CSNK2A2/BAX/TLR7	0.697523400037023
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	12/620	150/9376	1.2098064516129	HGF/WNT2/RARB/FGF7/CCND1/FGF10/CTNNA2/LRP6/BAX/FZD4/SMAD2/DVL3	0.689265196024586
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	9/620	109/9376	1.24865344776561	SPP1/CD14/JUN/CCL4L2/CCL4/FOS/TLR7/TICAM2/CD40	0.6948111183306
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/620	109/9376	1.24865344776561	JUN/IL6ST/FOS/NFATC2/RORA/SMAD2/EBI3/IL21R/CD4	0.6948111183306
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	15/620	193/9376	1.17533010195554	CXCL14/CCL2/GNGT1/GNG11/CCL4L2/CCL4/GNAI1/CCL13/PLCB1/PARD3/GNG10/PRKACA/GNB2/CCL8/PTK2	0.654894667516518
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/620	17/9376	1.77912713472486	INMT/PAPSS1	0.855552517129854
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/620	17/9376	1.77912713472486	CD209/MYH10	0.855552517129854
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/620	43/9376	1.40675168792198	CD36/PLPP3/PLA2G2A/SLC27A4	0.711347099797976
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/620	30/9376	1.51225806451613	FOLR2/ABCG2/MTHFR	0.747765027775712
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	12/620	154/9376	1.17838290741517	RYR2/CALM2/GNAI1/CREB3L1/AGTR1/PLCB1/CACNA2D1/PPP1CA/TPM1/PRKACA/SCN1B/PPP1CC	0.593922319194357
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/620	98/9376	1.23449637919684	CALM2/CREB3L1/PRKD1/AGTR1/PLCB1/KCNJ5/ITPR2/PRKACA	0.620941378569505
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	17/620	226/9376	1.13753925206965	RYR2/PDE3A/JUN/CGA/CALM2/GNAI1/CREB3L1/FOS/VIPR2/PDE4D/BDNF/GRIN2C/PPP1CA/GRIA4/GLI3/PRKACA/PPP1CC	0.556927851816025
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	13/620	170/9376	1.15643263757116	HGF/WNT2/IGF2/ACTB/CCND1/LRP6/BAX/SMARCE1/BRD7/FZD4/ACTG1/SMAD2/DVL3	0.547702785679057
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/620	18/9376	1.68028673835125	MAN2B1/MAN2C1	0.768714978522185
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	10/620	128/9376	1.18145161290323	ENPP1/PDE3A/GUCY1A2/GUCY1A1/PDE4D/HPRT1/AK1/ADSL/GMPS/PAPSS1	0.550009908879461
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/620	100/9376	1.2098064516129	CD36/CD14/CR1/KITLG/CD34/CD59/FCGR1A/CD4	0.561263855530811
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	15/620	200/9376	1.1341935483871	JUN/RPS3/TUBA1B/ACTB/FOS/TJP1/MYH10/ARHGEF12/BAIAP2/WASL/BAX/MYO1B/ACTG1/ARF6/NCKAP1	0.510444511743614
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/620	73/9376	1.24295183384887	BICD2/XPO1/SUPT4H1/BICD1/MLLT3/CD4	0.554496370308521
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/620	19/9376	1.5918505942275	GUSB/HYAL2	0.6871462491871
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/620	33/9376	1.37478005865103	IDH2/IDH3B/BCKDHA	0.573877076012021
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/620	75/9376	1.2098064516129	IGFBP3/IGF1/CCND1/CCND2/SIVA1/BAX	0.485415069580997
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	11/620	148/9376	1.12397558849172	WNT2/JUN/IGF1/FGF7/CCND1/FOS/FGF10/LRP6/BAX/FZD4/DVL3	0.404521724286627
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/620	34/9376	1.33434535104364	POLR2E/POLR2B/POLR1D	0.519688877927331
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/620	120/9376	1.1341935483871	JUN/CALM2/BDNF/BAX/KIDINS220/MAP2K5/IRS1/PRDM4/MAP3K3	0.393676230250255
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/620	63/9376	1.20020481310804	RAD23A/POLR2E/POLR2B/POLD1/POLE3	0.424256586968905
Cellular Processes	Cell motility	hsa04814	Motor proteins	14/620	194/9376	1.0913202527436	TUBA1B/ACTB/MYH10/KIF26B/TNNT3/DNAH8/TPM1/MYO1B/TNNT1/KLC1/ACTG1/MYO18A/DYNLL2/DYNLT3	0.342001437945256
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	21/620	298/9376	1.06568521324962	CXCL14/BMP5/CCL2/CSH1/EDA/IL12RB2/IL6ST/PRLR/BMP4/CCL4L2/CCL4/CCL13/TNFRSF25/BMPR1A/CD40/EBI3/LIFR/CCL8/IL21R/CD4/GHR	0.306626201895486
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/620	93/9376	1.13825875823795	MAF/RBPJ/JUN/IL12RB2/FOS/NFATC2/CD4	0.356548453875006
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/620	93/9376	1.13825875823795	PRKG1/CALM2/GUCY1A2/GUCY1A1/PLCB1/ITPR2/PRKACA	0.356548453875006
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	21/620	300/9376	1.05858064516129	HGF/CD14/JUN/MEF2C/IGF1/PDGFRA/ANGPT1/IGF2/FGF7/KITLG/PDGFC/FOS/FLT1/BDNF/FGF10/CACNA2D1/PRKACA/MAP2K5/ELK4/MAP3K3/KDR	0.27440760326837
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/620	36/9376	1.26021505376344	RNASEH2C/POLD1/POLE3	0.416235230226438
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	10/620	138/9376	1.0958391771856	CALM2/RPS6/PPP1CA/PRKACA/PRKAR2A/PPP1CC/IRS1/PTPRF/PHKG2/SOCS2	0.301802092961651
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/620	65/9376	1.16327543424318	CREB3L1/AGTR1/PLCB1/ITPR2/PRKACA	0.351485949503153
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/620	51/9376	1.18608475648324	ENPP2/PLPP3/PLA2G2A/PLD4	0.354568436871458
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/620	51/9376	1.18608475648324	ACTB/TJP1/PRKACA/ACTG1	0.354568436871458
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/620	95/9376	1.11429541595925	CCL2/JUN/CD28/ANGPT1/FOS/FLT1/MMP1	0.297935212834411
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/620	37/9376	1.22615518744551	CCND1/BAX/CCDC6	0.366763268740386
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/620	52/9376	1.16327543424318	HSD17B2/IGF1/CGA/PRKACA	0.314159352651166
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	15/620	216/9376	1.05017921146953	CD36/CD14/CCL2/JUN/VCAM1/CALM2/FOS/PLCB1/NFATC2/MMP1/BAX/TICAM2/CD40/HSPA4/PTK2	0.198532484557456
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/620	38/9376	1.19388794567063	IGF1/NR3C2/IRS1	0.318672273778497
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/620	68/9376	1.11195445920304	CD14/RUNX1T1/CCND1/FCGR1A/PIM1	0.246545041231833
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/620	144/9376	1.05017921146953	WNT2/IL6ST/IGF1/BMP4/FZD4/SMAD2/BMPR1A/DVL3/MEIS1/LIFR	0.161467747576068
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/620	99/9376	1.0692733789508	IGF1/CALM2/PLCB1/ITPR2/PPP1CA/PRKACA/PPP1CC	0.184377871577127
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/620	100/9376	1.05858064516129	CXCL14/CCL2/IL6ST/CCL4L2/CCL4/CCL13/CCL8	0.15671204822324
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/620	55/9376	1.09982404692082	PLPP3/SPTLC1/DEGS1/CERS5	0.197566756358252
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	17/620	253/9376	1.01614178248119	CD14/RPS27A/JUN/UBB/UBA52/ACTB/PLCB1/ITPR2/UBE2V2/WASL/BAX/VDAC1/ACTG1/UBE2V1/PTK2/ARF6/CAPNS1	0.0692582510556656
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/620	41/9376	1.10653029110936	GABRA3/GRIN2C/GRIA4	0.181901586762189
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/620	41/9376	1.10653029110936	CCND1/MMP2/MMP1	0.181901586762189
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/620	42/9376	1.08018433179724	AOC1/INMT/CAT	0.138582651957003
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/620	42/9376	1.08018433179724	SLC40A1/FTL/VDAC2	0.138582651957003
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/620	27/9376	1.12019115890084	ELOVL2/FADS1	0.16641805097693
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	9/620	137/9376	0.9934542029668	JUN/CTSC/TUBA1B/ACTB/FOS/ITPR2/BAX/ACTG1/SPTAN1	-0.0205370916610189
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/620	75/9376	1.00817204301075	CGA/CREB3L1/PLCB1/ITPR2/PRKACA	0.0189071060312401
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/620	12/9376	1.26021505376344	CD209	0.240005361985247
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/620	44/9376	1.03108504398827	TAF10/GTF2F1/GTF2E2	0.0549944756974119
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/620	44/9376	1.03108504398827	XRCC1/POLD1/POLE3	0.0549944756974119
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/620	44/9376	1.03108504398827	CREB3L1/PRKACA/DYNLL2	0.0549944756974119
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/620	107/9376	0.989327705758215	CALM2/CREB3L1/PLCB1/ITPR2/PRKACA/SLC2A1/PHKG2	-0.0295434932076072
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/620	76/9376	0.99490662139219	IGF1/PDGFRA/CALM2/CCND1/BAX	-0.0118631463548488
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	10/620	155/9376	0.975650364203954	CD36/CD14/MRC1/COLEC12/TUBA1B/ACTB/CD209/C1R/FCGR1A/ACTG1	-0.0813388287290242
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	10/620	155/9376	0.975650364203954	WNT2/GNAI1/CREB3L1/CCND1/AGTR1/PLCB1/ITPR2/PRKACA/FZD4/DVL3	-0.0813388287290242
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/620	29/9376	1.04293659621802	YAP1/FAT4	0.0616196315339732
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/620	29/9376	1.04293659621802	GNGT1/CALM2	0.0616196315339732
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	16/620	250/9376	0.967845161290322	DAB2/FOLR2/WWP1/PDGFRA/CAV1/ARF5/PARD3/ARF3/CAV2/WASL/SNX6/RNF41/SMAD2/RAB4A/SNX12/ARF6	-0.137121234360279
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/620	62/9376	0.975650364203954	RBPJ/HDAC1/DVL3/HDAC2	-0.0511857185335551
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/620	78/9376	0.969396195202647	JUN/CR1/EEF1A1/FOS/FCGR1A	-0.0722198463520617
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/620	94/9376	0.965271105010295	CCL2/JUN/FOS/ANAPC5/MMP1/SRSF1	-0.090045645630401
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	9/620	142/9376	0.958473421172194	RPS27A/WWP1/UBB/UBA52/UBE2G2/PPIL2/ANAPC5/UBE2Q1/UBA2	-0.132679552102477
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	13/620	205/9376	0.958992918961448	RBPJ/JUN/IL6ST/HDAC9/CREB3L1/CCND1/CCND2/PSMC1/PRKACA/BAX/HDAC1/GTF2E2/HDAC2	-0.157963245011631
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/620	63/9376	0.960163850486431	PRDM6/NSD1/EHMT1/PLOD2	-0.0844172953099253
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	9/620	143/9376	0.951770809835326	C1QA/C1QB/C1QC/C7/CD28/C1R/FCGR1A/C2/CD40	-0.154644748648094
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/620	112/9376	0.945161290322581	LAMA2/LAMC1/LAMA4/LAMC3/GNAI1/LAMB2/CD40	-0.155355120510297
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/620	31/9376	0.975650364203954	GUSB/KL	-0.0361336863379705
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/620	31/9376	0.975650364203954	ACSS1/CAT	-0.0361336863379705
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/620	32/9376	0.945161290322581	AKR1B1/GAA	-0.0826845578382132
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/620	32/9376	0.945161290322581	ATG101/IGBP1	-0.0826845578382132
Human Diseases	Immune disease	hsa05310	Asthma	2/620	32/9376	0.945161290322581	PRG2/CD40	-0.0826845578382132
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/620	15/9376	1.00817204301075	AK1	0.00842837319308939
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/620	99/9376	0.916520039100684	PLPP3/JUN/PDGFRA/PDGFC/FOS/SLC22A3	-0.222190078542145
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	13/620	214/9376	0.9186614410612	GNGT1/JUN/GNG11/CALM2/GNAI1/FOS/NFATC2/ITPR2/GNG10/BAX/GNB2/CD4/PTK2	-0.32028516487993
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/620	85/9376	0.889563567362429	ENPP1/HPRT1/AK1/ADSL/GMPS	-0.272156811820117
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	15/620	248/9376	0.914672216441207	CD14/JUN/RPS3/TUBA1B/ACTB/FOS/WASL/BAX/KLC1/ACTG1/STX10/DYNLL2/ARF6/NCKAP1/DYNLT3	-0.362374055095125
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/620	86/9376	0.879219804951238	RYR2/CREB3L1/PLCB1/PRKACA/SLC2A1	-0.299409586684794
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/620	35/9376	0.864147465437788	ENOSF1/AKR1B1	-0.214256343010286
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/620	17/9376	0.889563567362429	CA8	-0.121269255959468
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/620	70/9376	0.864147465437788	CD36/ADIPOR1/IRS1/SLC2A1	-0.303573492985436
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/620	53/9376	0.855995130858186	PLCB1/PRKACA/KL	-0.279747282253794
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/620	87/9376	0.869113830181683	JUN/CCND1/FOS/BAX/SMAD2	-0.326360440248884
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/620	36/9376	0.840143369175627	ENPP1/GAA	-0.255703736475195
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/620	71/9376	0.851976374375284	JUN/TJP1/JAM3/JAM2	-0.333142951858227
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	8/620	138/9376	0.876671341748481	IGF1/CALM2/ITPR2/PPP1CA/ANAPC5/PRKACA/PPP1CC/SMC1A	-0.388367766455042
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	6/620	105/9376	0.864147465437788	JUN/CALM2/CD209/NFATC2/ARHGEF12/ITPR2	-0.372501229749678
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/620	54/9376	0.840143369175627	CGA/CD28/CD40	-0.313474048304974
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/620	122/9376	0.867689053410894	CD36/IGF1/CREB3L1/CCND1/RAB14/ADIPOR1/IRS1	-0.3914168799372
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/620	18/9376	0.840143369175627	HCFC1	-0.1806358695579
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	6/620	106/9376	0.855995130858186	FOLR2/IGF1/PDGFRA/CREB3L1/CCND1/PDGFC	-0.396751748074915
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	12/620	205/9376	0.88522423288749	RBPJ/JUN/CCND1/CCND2/PSMD2/PSMC1/PSMD4/BAX/ADRM1/HDAC1/CD40/HDAC2	-0.442127363436237
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/620	73/9376	0.828634555899249	HGF/RARB/CCND1/BAX	-0.39111257258211
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	10/620	174/9376	0.869113830181683	RAD23A/BAG1/UBE2G2/TUSC3/MAN1A1/PDIA6/BAX/RNF5/LMAN2/PRKCSH	-0.463720051167126
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/620	56/9376	0.810138248847926	SRD5A3/TUSC3/MAN1A1	-0.379185870536185
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	9/620	158/9376	0.86141282155982	CDKN1C/CDC14B/CCND1/CCND2/ANAPC5/SMC1A/HDAC1/SMAD2/HDAC2	-0.467478725069663
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	9/620	158/9376	0.86141282155982	WNT2/IGF1/RPS6/LRP6/EIF4B/FZD4/IRS1/DVL3/MIOS	-0.467478725069663
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/620	38/9376	0.795925297113752	CD40/CD4	-0.335415125290503
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/620	19/9376	0.795925297113752	BCKDHA	-0.236933388273923
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/620	125/9376	0.846864516129032	GNAI1/PLCB1/SPTLC1/BAX/DEGS1/CERS5/SPTSSA	-0.45863279658072
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/620	39/9376	0.775516956162117	CD28/CD40	-0.373801270431363
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/620	20/9376	0.756129032258064	NANS	-0.29050833643512
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/620	76/9376	0.795925297113752	PLTP/CD36/SLC27A4/MMP1	-0.475316730617603
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	11/620	195/9376	0.853068651778329	HDAC9/CR1/ACTB/PLCB1/VDAC2/FCGR1A/TLR7/VDAC1/HDAC1/ACTG1/HDAC2	-0.551715750068353
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/620	59/9376	0.768944778567523	HPGDS/TXNDC12/IDH2	-0.473731596459389
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/620	59/9376	0.768944778567523	CCND1/CTNNA2/BAX	-0.473731596459389
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/620	77/9376	0.785588604943444	CCND1/BAX/HDAC1/HDAC2	-0.50269400708546
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/620	21/9376	0.720122887864823	CHSY3	-0.341651822706844
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/620	21/9376	0.720122887864823	ENPP1	-0.341651822706844
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/620	60/9376	0.756129032258064	NFATC2/KDR/PTK2	-0.504254280384906
NA	NA	hsa04082	Neuroactive ligand signaling	11/620	199/9376	0.83592154319987	GNGT1/GNG11/TAC3/GNAI1/PLCB1/GABRA3/GNG10/GRIN2C/GRIA4/PRKACA/GNB2	-0.62252434725032
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/620	149/9376	0.811950638666378	PLPP3/PDGFRA/KITLG/PDGFC/AGTR1/PLCB1/PTGFR/ARF6	-0.615691762626992
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/620	22/9376	0.687390029325513	AOC1	-0.390610658698205
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/620	98/9376	0.771560236998025	CALM2/PLCB1/ITPR2/PIP4P1/PPIP5K2	-0.604903588892808
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	6/620	116/9376	0.782202447163515	IDH2/ACSS1/CAT/SUCLA2/IDH3B/SDHC	-0.62806573933385
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/620	23/9376	0.65750350631136	POLD1	-0.437595842382794
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/620	23/9376	0.65750350631136	AGTR1	-0.437595842382794
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/620	44/9376	0.687390029325513	TUSC3/MAN1A1	-0.553057651824915
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/620	82/9376	0.737686860739575	LGMN/PSME3/HSPA4/CD4	-0.634825324825487
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	4/620	83/9376	0.728799067236689	CCL4L2/CCL4/POLR2E/POLR1D	-0.660360158374505
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/620	102/9376	0.741302972802024	RYR2/PLA2G2A/PLCB1/ITPR2/TRPC1	-0.69901514390509
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/620	47/9376	0.643514070006863	IRS1/SOCS2	-0.651932125495976
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/620	86/9376	0.70337584396099	SCN9A/PLCB1/GABRA3/PRKACA	-0.735320189907873
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/620	26/9376	0.581637717121588	PLA2G2A	-0.568410378719034
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/620	48/9376	0.63010752688172	HMGCLL1/BCKDHA	-0.683644698813492
NA	NA	hsa03272	Virion - Hepatitis viruses	2/620	48/9376	0.63010752688172	CD63/DPP4	-0.683644698813492
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	7/620	142/9376	0.745479327578373	JUN/LILRB5/FOS/NFATC2/ITPR2/FCGR1A/FHL2	-0.81320662021671
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/620	27/9376	0.560095579450418	HMGCLL1	-0.609096683595483
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	7/620	144/9376	0.735125448028674	C1QA/C1QB/C1QC/CD14/CCND1/ADIPOR1/C2	-0.852319038990817
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/620	70/9376	0.648110599078341	HGF/JUN/SLC2A1	-0.786325370568788
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/620	50/9376	0.604903225806452	CD28/CD40	-0.745365671359708
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/620	28/9376	0.540092165898618	ELOVL2	-0.648513584517122
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/620	28/9376	0.540092165898618	AKR1B1	-0.648513584517122
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/620	71/9376	0.638982280781463	PDGFRA/IDH2/SLC2A1	-0.812508869080868
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/620	91/9376	0.664728819567529	JUN/LILRB5/FOS/NFATC2	-0.855174164765404
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	5/620	110/9376	0.687390029325513	IGF1/ANGPT1/RPS6/FLT1/SLC2A1	-0.877569714103189
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	9/620	183/9376	0.743733474352195	FBL/CSNK2B/SBDS/EIF6/CSNK2A2/RPP25/GNL3/XPO1/LSG1	-0.931574092845813
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/620	30/9376	0.504086021505376	PLA2G2A	-0.723906865680433
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	8/620	169/9376	0.715861805688108	RPS27A/UBB/UBA52/ATG101/PRKACA/IGBP1/IRS1/RUBCN	-0.9918420198656
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/620	32/9376	0.47258064516129	BAX	-0.795230894502816
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	7/620	154/9376	0.687390029325513	ALAS2/GUSB/RDH11/AK1/ADSL/RFK/COX15	-1.04082863922694
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/620	77/9376	0.589191453707583	CCND1/BAX/SMAD2	-0.963153074146155
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/620	33/9376	0.458260019550342	VTI1B	-0.829532278366881
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/620	57/9376	0.530616864742501	ELOVL2/FADS1	-0.945820798755523
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	5/620	119/9376	0.635402548116021	CCL2/JUN/VCAM1/CREB3L1/FOS	-1.06507596534381
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/620	34/9376	0.444781783681214	RORA	-0.863002075377622
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	5/620	122/9376	0.619777895293495	JUN/CD28/FOS/NFATC2/CD4	-1.12481509462369
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/620	82/9376	0.553265145554681	GUSB/HPRT1/GMPS	-1.08114522926188
NA	NA	hsa04382	Cornified envelope formation	10/620	217/9376	0.696893117288539	COL4A1/KRT18/COL4A2/KRT19/KRT7/TJP1/SLC27A4/SPTLC1/KRT1/KRT8	-1.20207133795857
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/620	181/9376	0.668401354482267	CD14/MRC1/CR1/CALM2/CD209/ARHGEF12/BAX/FCGR1A	-1.19868418395761
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/620	61/9376	0.495822316234797	SLC40A1/FTL	-1.05120087360051
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/620	83/9376	0.546599300427516	HMGCLL1/IDH2/CAT	-1.10400710914259
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/620	37/9376	0.40871839581517	ADSL	-0.958900728063723
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/620	37/9376	0.40871839581517	NANS	-0.958900728063723
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/620	38/9376	0.397962648556876	ENPP1	-0.989502524359502
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/620	39/9376	0.387758478081059	MTHFR	-1.0194830522229
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/620	65/9376	0.46531017369727	PLPP3/AKR1B1	-1.1510363586465
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/620	66/9376	0.458260019550342	HSD17B2/SRD5A3	-1.17521309367524
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/620	110/9376	0.549912023460411	IGF1/GNAI1/ANAPC5/PRKACA	-1.2635028116375
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/620	41/9376	0.368843430369788	ALAS2	-1.07770644682886
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/620	41/9376	0.368843430369788	POLD1	-1.07770644682886
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/620	90/9376	0.504086021505376	ABCG2/PRKACA/SLC2A1	-1.2578877033047
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	5/620	133/9376	0.568518069366966	IGF1/CCND1/CCND2/CAT/IRS1	-1.33355386904067
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	7/620	173/9376	0.611896326682827	CCL2/ACTB/BAX/TLR7/VDAC1/XPO1/ACTG1	-1.3709913045802
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	11/620	250/9376	0.665393548387097	LGMN/CTSC/CD63/MAN2B1/GUSB/OSBPL6/TLR7/TPCN1/NPC2/HYAL2/GAA	-1.42689721084701
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/620	44/9376	0.343695014662757	CD28	-1.16110977934724
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/620	45/9376	0.336057347670251	ABCG2	-1.18795868711117
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/620	45/9376	0.336057347670251	CD28	-1.18795868711117
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	9/620	217/9376	0.627203805559685	JUN/FGF7/GNAI1/CREB3L1/CCND1/FOS/FGF10/PRKACA/PTGES3	-1.47844752394924
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/620	47/9376	0.321757035003432	ACSS1	-1.24035295805761
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/620	98/9376	0.462936142198815	PLPP3/FCGR1A/ARF6	-1.42213356720102
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/620	48/9376	0.31505376344086	PLCB1	-1.2659350963494
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	6/620	163/9376	0.556659410251336	JUN/CREB3L1/FOS/NFATC2/BAX/TICAM2	-1.51935537916695
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/620	75/9376	0.403268817204301	IDH2/IDH3B	-1.38061678461803
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/620	49/9376	0.30862409479921	GXYLT2	-1.29112977984747
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/620	50/9376	0.302451612903226	AOC1	-1.31595258633918
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	7/620	187/9376	0.566085906503364	CCL2/JUN/ANTXR1/PLCB1/VDAC2/ITPR2/VDAC1	-1.59484705294386
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/620	78/9376	0.387758478081059	PLCB1/PPIP5K2	-1.44478730458909
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/620	104/9376	0.436228287841191	PLPP3/PLA2G2A/PLD4	-1.53837369633287
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/620	54/9376	0.280047789725209	DNMT1	-1.41180464505663
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/620	54/9376	0.280047789725209	REV1	-1.41180464505663
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	16/620	370/9376	0.653949433304272	SPX/CSH1/PRLR/TAC3/CGA/LYPD6/AGTR1/KISS1/VIPR2/GABRA3/GRIN2C/APLN/GRIA4/PTGFR/GHR/APLNR	-1.80718686757872
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/620	86/9376	0.351687921980495	JUN/PTK2	-1.60714139635403
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	6/620	180/9376	0.504086021505376	CCL2/PPP1CA/HCFC1/BAX/PPP1CC/SRSF1	-1.78760568777955
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/620	59/9376	0.256314926189174	ENPP1	-1.5247745326646
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	13/620	323/9376	0.608648756616399	TIMP3/FSCN1/PDGFRA/ZFPM2/CCND1/CCND2/TNXB/DNMT1/TPM1/HDAC1/IRS1/PIM1/HDAC2	-1.90458485019031
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/620	168/9376	0.450076804915515	FTL/VDAC2/BAX/VDAC1/TICAM2	-1.91382679232992
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/620	67/9376	0.225710158883004	ACSS1	-1.69245859973644
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/620	68/9376	0.222390891840607	RDH11	-1.71244335418314
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/620	70/9376	0.216036866359447	HPGDS	-1.75182912573549
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/620	73/9376	0.207158638974812	HPGDS	-1.80952598691806
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/620	75/9376	0.201634408602151	BAX	-1.84712474816779
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/620	78/9376	0.193879239040529	CNOT9	-1.90230979066809
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/620	79/9376	0.191425071457738	HPGDS	-1.92039695076188
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/620	79/9376	0.191425071457738	SYT1	-1.92039695076188
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	3/620	156/9376	0.290818858560794	CCND1/BAX/PSME3	-2.37674518889014
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2/620	133/9376	0.227407227746786	NFATC2/HCST	-2.38780353819121
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/620	449/9376	0.101041741504418	PRKG1/CALM2/PRKACA	-5.19443763127324