category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	114/1363	308/9376	2.54610246686549	MT-ND5/MT-ND1/MT-ND4/MT-ND3/MT-CYB/MT-CO3/MT-ND2/MT-CO1/MT-CO2/MT-ATP6/GRIA4/COX6C/CLTA/ATP5F1E/CLTC/PSMD2/UQCR10/UQCRB/UQCR11/SLC25A4/NDUFA6/PSMD9/PSMC4/PSMA3/ACTR1A/PSMA5/BDNF/COX4I2/PSMB3/PSMC3/UQCRFS1/HDAC2/PSMB4/COX7C/AP2S1/PSMC5/PSMB2/ATP5PB/NDUFA4/COX5A/ATP5PO/TUBA1B/NDUFV1/CREB3L1/ATP5F1B/PLCB2/POLR2E/PSMC6/PSMD3/CYC1/PSMD8/POLR2D/TP53/NDUFA12/NDUFA13/PSMB6/GPX8/UQCRQ/NDUFA4L2/MT-ND6/ATP5PD/COX7A2L/PSMC2/NDUFS7/DNAH8/DCTN2/COX8A/NDUFC2/NDUFB6/NDUFA7/DCTN1/MAP2K7/BAX/NDUFA9/PSMA2/DCTN3/NDUFB11/COX5B/SDHD/PSMA1/POLR2H/TUBB3/NDUFV3/PSMD13/DCTN6/SDHC/COX6B1/POLR2F/NDUFB5/ATG14/ATP5F1A/TAF4/AP2A1/ATP5MC1/DLG4/NDUFS8/APAF1/DCTN5/DNAH1/NDUFB1/TUBA1A/PSMB1/NDUFB9/ATP5MC2/VDAC3/POLR2J3/MTOR/HTT/AMBRA1/POLR2G/ATP5MC3/PIK3R4/MAPK9/NDUFS1	11.3787320429824
Genetic Information Processing	Translation	hsa03010	Ribosome	92/1363	222/9376	2.85073334523078	RPS23/RPL27A/RPS18/RPL37A/RPL23A/RPS11/RPL36/RPL37/RPS14/RPL32/RPL29/RPL35/RPL38/RPLP2/RPL7A/RPL23/RPS4X/RPL14/RPS12/RPL27/RPL19/RPLP1/RPL41/RPL15/RPL26/RPS24/RPL24/RPS28/RPS15/RPS27A/UBA52/MRPL47/RPL39/MRPS6/RPL10A/MRPL55/MRPL44/MRPL54/RPL8/RSL24D1/RPL22/MRPS25/MRPS15/RPS10/MRPS10/RPS7/RPS15A/RPS25/RPL3/MRPS7/MRPL21/RPL13A/RPL30/RPL5/RPL22L1/RPS21/RPL18A/RPL18/MRPL24/MRPS22/MRPS33/MRPL11/RPL36A/MRPL15/RPL7/MRPS16/MRPS18C/MRPL40/MRPL27/RPS3/RACK1/MRPS12/MRPL9/MRPS17/MRPS18B/MRPS14/MRPL4/RPL26L1/MRPL32/MRPL45/MRPS18A/MRPL50/MRPL13/MRPL37/MRPL38/MRPS27/RPS5/MRPL12/MRPL3/MRPL48/MRPL2/MRPL43	11.509352135814
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	85/1363	205/9376	2.85224486874362	CD36/COL3A1/COL1A1/MT-ND5/MT-ND1/MT-ND4/MT-ND3/MT-CYB/MT-CO3/MT-ND2/MT-CO1/MT-CO2/MT-ATP6/COL1A2/RYR2/TBC1D4/COX6C/ATP5F1E/CYBB/UQCR10/PRKCA/UQCRB/GAPDH/UQCR11/SLC25A4/NDUFA6/CYBA/COX4I2/UQCRFS1/COX7C/NCF4/ATP5PB/NDUFA4/COX5A/ATP5PO/NDUFV1/ATP5F1B/PLCB2/GFPT2/CYC1/PDHA1/AKT2/NDUFA12/NDUFA13/UQCRQ/NDUFA4L2/AKT1/MT-ND6/PDK4/RAC2/ATP5PD/COX7A2L/NDUFS7/IRS1/COX8A/NDUFC2/NDUFB6/NDUFA7/NDUFA9/NDUFB11/PPP1CC/AGTR1/COX5B/SDHD/NDUFV3/SDHC/COX6B1/NDUFB5/ATP5F1A/PPP1CA/ATP5MC1/G6PD/PTPA/NDUFS8/NDUFB1/NDUFB9/ATP5MC2/VDAC3/MTOR/SLC2A1/ATP5MC3/PARP1/MAPK9/NDUFS1/PIK3R2	11.0586720458275
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	98/1363	268/9376	2.51543456598154	MT-ND5/MT-ND1/MT-ND4/MT-ND3/MT-CYB/MT-CO3/MT-ND2/MT-CO1/MT-CO2/MT-ATP6/ITPR2/COX6C/ATP5F1E/CALM2/PRKN/PSMD2/UQCR10/UQCRB/UQCR11/SLC25A4/NDUFA6/PSMD9/PSMC4/PSMA3/PSMA5/UCHL1/UBE2J2/RPS27A/UBA52/COX4I2/UBE2L3/PSMB3/PSMC3/CALML4/UQCRFS1/PSMB4/COX7C/PSMC5/KEAP1/PSMB2/ATP5PB/NDUFA4/COX5A/ATP5PO/TUBA1B/NDUFV1/ATP5F1B/PSMC6/PSMD3/CYC1/PSMD8/TP53/NDUFA12/NDUFA13/PSMB6/UQCRQ/NDUFA4L2/MT-ND6/ATP5PD/COX7A2L/PSMC2/NDUFS7/COX8A/NDUFC2/NDUFB6/NDUFA7/BAX/NDUFA9/PSMA2/NDUFB11/SLC39A3/COX5B/SDHD/PSMA1/TUBB3/NDUFV3/PSMD13/SLC39A12/SDHC/COX6B1/NDUFB5/DAXX/ATP5F1A/ATP5MC1/NDUFS8/APAF1/NDUFB1/TUBA1A/PSMB1/NDUFB9/ATP5MC2/VDAC3/GNAI2/PARK7/ATP5MC3/MAPK9/NDUFS1/HTRA2	10.3807580725038
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	117/1363	368/9376	2.18705540846598	MT-ND5/MT-ND1/MT-ND4/MT-ND3/MT-CYB/MT-CO3/MT-ND2/MT-CO1/MT-CO2/MT-ATP6/ACTB/GRIN2C/COX6C/ATP5F1E/ACTG1/TNFRSF1A/PRKN/PSMD2/UQCR10/UQCRB/UQCR11/NDUFA6/PSMD9/PSMC4/PSMA3/ACTR1A/PSMA5/OPTN/COX4I2/PSMB3/PSMC3/UQCRFS1/PSMB4/NUP54/COX7C/ALYREF/PSMC5/PSMB2/ATP5PB/SEH1L/NDUFA4/COX5A/ATP5PO/TUBA1B/NDUFV1/ATP5F1B/PSMC6/PSMD3/RAE1/CYC1/PSMD8/TP53/NDUFA12/NDUFA13/PSMB6/GPX8/UQCRQ/NDUFA4L2/MT-ND6/ATP5PD/COX7A2L/PSMC2/NDUFS7/NUP214/DNAH8/PFN2/DCTN2/COX8A/NDUFC2/NDUFB6/NDUFA7/DCTN1/BAX/NDUFA9/PSMA2/DCTN3/NDUFB11/PPP3CB/CHCHD10/COX5B/SDHD/PSMA1/UBQLN2/TUBB3/NDUFV3/PSMD13/PFN1/DCTN6/SDHC/COX6B1/POM121/NDUFB5/SMCR8/ATG14/DAXX/ATP5F1A/ATP5MC1/TOMM40/NDUFS8/ERBB4/APAF1/DCTN5/DNAH1/NDUFB1/TUBA1A/PSMB1/NDUFB9/ATP5MC2/NUP133/NUP155/MTOR/AMBRA1/ATP5MC3/PIK3R4/NDUFS1/NUP160/GLE1	9.58112941678655
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	96/1363	275/9376	2.40137664243314	MT-ND5/MT-ND1/MT-ND4/MT-ND3/MT-CYB/MT-CO3/MT-ND2/MT-CO1/MT-CO2/MT-ATP6/ITPR2/RYR2/GRIN2C/COX6C/ATP5F1E/LAMC1/CYBB/PSMD2/UQCR10/UQCRB/UQCR11/SLC25A4/NDUFA6/PSMD9/PSMC4/RYR1/PSMA3/PSMA5/CYBA/COX4I2/PSMB3/PSMC3/UQCRFS1/PSMB4/COX7C/PSMC5/NCF4/PSMB2/ATP5PB/NDUFA4/COX5A/ATP5PO/TUBA1B/NDUFV1/CREB3L1/ATP5F1B/PSMC6/PSMD3/CYC1/PSMD8/NDUFA12/NDUFA13/PSMB6/UQCRQ/NDUFA4L2/MT-ND6/RAC2/ATP5PD/COX7A2L/PSMC2/NDUFS7/CSNK2A1/COX8A/NDUFC2/NDUFB6/NDUFA7/BAX/NDUFA9/CAV1/PSMA2/NDUFB11/PPP3CB/COX5B/SDHD/PSMA1/TUBB3/NDUFV3/PSMD13/SDHC/COX6B1/NDUFB5/ATP5F1A/ATP5MC1/NDUFS8/APAF1/NDUFB1/TUBA1A/PSMB1/NDUFB9/ATP5MC2/VDAC3/C9/ATP5MC3/MAPK9/NDUFS1/PIK3R2	9.72775578362662
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	117/1363	388/9376	2.0743205935966	MT-ND5/MT-ND1/MT-ND4/MT-ND3/MT-CYB/MT-CO3/MT-ND2/MT-CO1/MT-CO2/MT-ATP6/ITPR2/WNT2/GRIN2C/COX6C/ATP5F1E/CALM2/CYBB/TNFRSF1A/PSMD2/UQCR10/UQCRB/GAPDH/UQCR11/SLC25A4/NDUFA6/PSMD9/PSMC4/PSMA3/PSMA5/COX4I2/PSMB3/PSMC3/CALML4/UQCRFS1/PSMB4/COX7C/PSMC5/PSMB2/LRP6/ATP5PB/NDUFA4/COX5A/ATP5PO/APH1A/TUBA1B/NDUFV1/ATP5F1B/PLCB2/PSMC6/PSMD3/CYC1/PSMD8/ADAM10/AKT2/NDUFA12/NDUFA13/PSMB6/UQCRQ/NDUFA4L2/AKT1/MT-ND6/IKBKG/ATP5PD/COX7A2L/PSMC2/NDUFS7/IRS1/CSNK2A1/COX8A/NDUFC2/NDUFB6/NDUFA7/CSNK1E/MAP2K7/NDUFA9/PSMA2/NDUFB11/PPP3CB/HSD17B10/SLC39A3/COX5B/SDHD/PSMA1/TUBB3/NDUFV3/PSMD13/SLC39A12/SDHC/COX6B1/NDUFB5/ATG14/ATP5F1A/APH1B/ATP5MC1/BACE2/PSENEN/NDUFS8/DKK2/APAF1/NDUFB1/TUBA1A/PSMB1/NDUFB9/DVL2/ATP5MC2/IKBKB/FZD4/VDAC3/MTOR/AMBRA1/DVL1/ATP5MC3/CSF1/PIK3R4/MAPK9/NDUFS1/PIK3R2	8.9136222757932
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	58/1363	138/9376	2.89115016959605	MT-ND5/MT-ND1/MT-ND4/MT-ND3/MT-CYB/MT-CO3/MT-ND2/MT-CO1/MT-CO2/MT-ATP6/COX6C/ATP5F1E/UQCR10/UQCRB/UQCR11/NDUFA6/ATP5MG/COX17/COX4I2/UQCRFS1/COX7C/ATP5PB/NDUFA4/COX5A/ATP5PO/NDUFV1/ATP5F1B/CYC1/ATP5MF/NDUFA12/NDUFA13/UQCRQ/NDUFA4L2/MT-ND6/ATP5PD/COX7A2L/NDUFS7/COX8A/NDUFC2/NDUFB6/NDUFA7/NDUFA9/NDUFB11/COX5B/SDHD/NDUFV3/SDHC/COX6B1/NDUFB5/ATP5F1A/ATP5MC1/NDUFS8/NDUFB1/NDUFB9/ATP5MC2/ATP6V1C2/ATP5MC3/NDUFS1	9.23023110608628
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	81/1363	235/9376	2.3710401024024	MT-ND5/MT-ND1/MT-ND4/MT-ND3/MT-CYB/MT-CO3/MT-ND2/MT-CO1/MT-CO2/MT-ATP6/PRKG1/ACTB/COX6C/ATP5F1E/ACTG1/UQCR10/UQCRB/UQCR11/NDUFA6/ATP5MG/COX17/COX4I2/UQCRFS1/SMARCA4/COX7C/ATP5PB/NDUFA4/COX5A/ATP5PO/NDUFV1/CREB3L1/COX19/ATP5F1B/COA6/CYC1/ATP5MF/PRKAG1/NDUFA12/NDUFA13/UQCRQ/NDUFA4L2/MT-ND6/NDUFAF6/ATP5PD/COX7A2L/NDUFS7/COX18/COX8A/NDUFC2/NDUFB6/NDUFA7/NDUFA9/SMARCD2/NDUFB11/NDUFAF4/PRKAA1/COX5B/SDHD/NDUFV3/SIRT6/SMARCB1/SDHC/COX6B1/NDUFB5/TSC1/ATP5F1A/ARID1A/ATP5MC1/NDUFAF7/RPS6KB2/NDUFS8/COA4/COA3/NDUFB1/NDUFB9/ATP5MC2/MTOR/ARID1B/ATP5MC3/NDUFAF1/NDUFS1	8.7785589392648
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	132/1363	480/9376	1.89170946441673	MT-ND5/MT-ND1/MT-ND4/MT-ND3/MT-CYB/MT-CO3/MT-ND2/MT-CO1/MT-CO2/MT-ATP6/ITPR2/WNT2/RYR2/GRIA4/GRIN2C/COX6C/ATP5F1E/CALM2/CYBB/TNFRSF1A/PRKN/PSMD2/UQCR10/PRKCA/UQCRB/UQCR11/SLC25A4/NDUFA6/PSMD9/PSMC4/RYR1/PSMA3/ACTR1A/PSMA5/UCHL1/UBE2J2/RPS27A/OPTN/BDNF/UBA52/COX4I2/UBE2L3/PSMB3/PSMC3/CALML4/UQCRFS1/PSMB4/COX7C/PSMC5/PSMB2/LRP6/ATP5PB/NDUFA4/COX5A/ATP5PO/TUBA1B/NDUFV1/ATP5F1B/PLCB2/PSMC6/PSMD3/CYC1/PSMD8/NDUFA12/NDUFA13/PSMB6/GPX8/UQCRQ/NDUFA4L2/MT-ND6/ATP5PD/COX7A2L/PSMC2/NDUFS7/DNAH8/CSNK2A1/DCTN2/COX8A/NDUFC2/NDUFB6/NDUFA7/DCTN1/CSNK1E/MAP2K7/BAX/NDUFA9/PSMA2/DCTN3/NDUFB11/PPP3CB/HSD17B10/COX5B/SDHD/PSMA1/TUBB3/NDUFV3/PSMD13/DCTN6/SDHC/COX6B1/NDUFB5/SMCR8/ATG14/DAXX/ATP5F1A/ATP5MC1/TOMM40/DLG4/NDUFS8/DKK2/APAF1/DCTN5/DNAH1/NDUFB1/TUBA1A/PSMB1/NDUFB9/DVL2/ATP5MC2/FZD4/VDAC3/MTOR/HTT/AMBRA1/PARK7/DVL1/ATP5MC3/CSF1/PIK3R4/MAPK9/NDUFS1/HTRA2	8.27146816325721
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	78/1363	227/9376	2.36368983939936	MT-ND5/MT-ND1/MT-ND4/MT-ND3/MT-CYB/MT-CO3/MT-ND2/MT-CO1/MT-CO2/MT-ATP6/HGF/COX6C/ATP5F1E/EGFR/UQCR10/UQCRB/UQCR11/SLC25A4/NDUFA6/CYBA/COX4I2/UQCRFS1/PTK2/COX7C/KEAP1/PLD1/PRKD1/ATP5PB/NDUFA4/GSTA4/COX5A/ATP5PO/NDUFV1/ATP5F1B/NQO1/CYC1/AKT2/NDUFA12/NDUFA13/UQCRQ/NDUFA4L2/AKT1/MT-ND6/IKBKG/ATP5PD/COX7A2L/NDUFS7/SLC26A2/COX8A/NDUFC2/NDUFB6/NDUFA7/ACP1/MAP2K7/NDUFA9/NDUFB11/MGST2/MGST1/COX5B/SDHD/NDUFV3/SDHC/COX6B1/NDUFB5/ATP5F1A/ATP5MC1/NDUFS8/NDUFB1/NDUFB9/ATP5MC2/IKBKB/VDAC3/ATP5MC3/GSTM4/MAPK9/NDUFS1/CBR1/PIK3R2	8.57783551653332
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	71/1363	238/9376	2.05212180249943	F13A1/CCL2/RPS23/RPL27A/RPS18/RPL37A/RPL23A/RPS11/RPL36/RPL37/RPS14/NRP1/RPL32/RPL29/IL6ST/RPL35/EGFR/RPL38/RPLP2/RPL7A/CYBB/RPL23/RPS4X/RPL14/RPS12/RPL27/RPL19/TNFRSF1A/RPLP1/RPL41/PRKCA/RPL15/RPL26/RPS24/RPL24/RPS28/RPS15/RPS27A/UBA52/RPL39/RPL10A/C1S/MMP1/RPL8/RSL24D1/RPL22/RPS10/RPS7/RPS15A/RPS25/RPL3/RPL13A/RPL30/IKBKG/RPL5/RPL22L1/RPS21/RPL18A/RPL18/RPL36A/C2/RPL7/AGTR1/TLR7/RPS3/RPL26L1/IKBKB/C9/MAPK9/RPS5/PIK3R2	6.78054990509547
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	49/1363	157/9376	2.14693141300335	MT-CYB/MT-CO3/MT-CO1/MT-CO2/COX6C/TNFRSF1A/UQCR10/UQCRB/UQCR11/NDUFA6/COX4I2/UQCRFS1/COX7C/NDUFA4/COX5A/NDUFV1/CYC1/AKT2/PRKAG1/NDUFA12/NDUFA13/UQCRQ/NDUFA4L2/AKT1/COX7A2L/NDUFS7/IRS1/COX8A/NDUFC2/NDUFB6/NDUFA7/BAX/NDUFA9/MLXIP/NDUFB11/PRKAA1/COX5B/SDHD/NDUFV3/SDHC/COX6B1/NDUFB5/NDUFS8/NDUFB1/NDUFB9/IKBKB/MAPK9/NDUFS1/PIK3R2	5.9769739242716
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	22/1363	46/9376	3.28992950333344	PSMD2/PSMD9/PSMC4/PSMA3/PSMA5/PSMB10/PSMB3/PSMC3/PSMB4/PSMB8/PSMC5/PSMB2/PSMC6/PSMD3/PSMD8/PSMB6/PSMF1/PSMC2/PSMA2/PSMA1/PSMD13/PSMB1	6.42090436256412
NA	NA	hsa04518	Integrin signaling	43/1363	154/9376	1.92074396623186	COL1A1/LAMA2/SPP1/COL1A2/ACTB/COL6A1/HGF/COL6A2/IGF1/ITGB5/EGFR/FREM1/LAMC1/ACTG1/PDGFC/CCND2/PDGFRA/LAMC3/VTN/VCAM1/PTK2/ITGA9/COL4A1/LAMA4/ITGAL/AKT2/FERMT3/AKT1/CCND1/RAC2/FRAS1/ITGA6/ILK/KDR/ITGA3/NCK2/COL6A6/TNXB/VEGFB/COL4A2/MTOR/ITGA11/PIK3R2	4.75141186406998
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	39/1363	144/9376	1.86304719980435	RBPJ/ITPR2/GRIN2C/PSMD2/PRKCA/SLC25A4/PSMD9/PSMC4/RYR1/PSMA3/PSMA5/CIC/PSMB3/PSMC3/PSMB4/PSMC5/PSMB2/PLCB2/PSMC6/PSMD3/PSMD8/AKT2/PSMB6/AKT1/PSMC2/NFYA/PSMA2/PSMA1/PSMD13/DAB1/ATG14/PSMB1/VDAC3/MTOR/AMBRA1/BEAN1/PIK3R4/MAPK9/PIK3R2	4.30431345556682
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	20/1363	56/9376	2.45676553820354	MAN1A1/ST6GAL1/MAN1C1/DPM1/MGAT2/TUSC3/GANAB/STT3A/ALG5/DPAGT1/DPM3/DOLK/FUT8/DDOST/MGAT4B/MAN1B1/OSTC/MAN1A2/ALG12/ALG9	4.50932680522596
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	78/1363	362/9376	1.48220329708192	MAGI1/COL1A1/LAMA2/SPP1/COL1A2/GNG2/GNGT1/COL6A1/HGF/GNG11/COL6A2/GNG10/IGF1/ITGB5/EGFR/CSH1/GNG12/CSF1R/LAMC1/FGF7/IGF2/ANGPT1/PDGFC/PRKCA/CCND2/PDGFRA/LAMC3/EFNA5/BDNF/VTN/EPOR/PTK2/ITGA9/FGF10/COL4A1/LAMA4/PPP2R1A/CREB3L1/THEM4/OSMR/PIK3CG/TP53/AKT2/EIF4E2/AKT1/CCND1/IKBKG/IRS1/PKN2/KITLG/ITGA6/KDR/ITGA3/FGFR3/LPAR5/PRKAA1/EPHA2/CDKN1B/TSC1/COL6A6/PPP2CB/TNXB/VEGFB/RPS6KB2/ERBB4/STK11/IKBKB/FGFR2/COL4A2/MTOR/ITGA11/IL2RB/CDK4/CSF1/LPAR6/MAGI2/PIK3R2/PPP2R5D	3.85888360055411
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	26/1363	87/9376	2.05577622047377	MT-CYB/MT-CO3/MT-CO1/MT-CO2/RYR2/TPM1/COX6C/CACNB4/UQCR10/UQCRB/UQCR11/ATP1B1/CACNA2D3/COX4I2/UQCRFS1/COX7C/COX5A/CACNA2D1/CYC1/UQCRQ/TNNT2/COX7A2L/COX8A/COX5B/COX6B1/TRDN	4.0802146952213
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	42/1363	170/9376	1.69950368995727	MAGI1/ACTB/ACTG1/MYL6/JAM3/GATA4/MPDZ/ARPC1B/PPP2R1A/AFDN/PARD3/CFTR/TJP1/WAS/TUBA1B/RAB13/MYL12A/DLG1/PRKAG1/CCND1/ARPC5L/AMOTL2/MYH10/MAP2K7/NF2/ARPC3/ARPC4/PRKAA1/ARHGEF18/PCNA/PPP2CB/CGNL1/EPB41L4B/AMOTL1/ARHGAP17/STK11/PARD6A/TUBA1A/CDK4/MYL6B/MAPK9/CLDN5	3.79590189824981
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	12/1363	30/9376	2.75157740278797	ACLY/MDH2/IDH3B/IDH3A/SUCLA2/PDHA1/IDH2/DLAT/SUCLG1/SDHD/DLD/SDHC	3.96289958018204
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	37/1363	149/9376	1.70819402522072	MT-ND5/MT-ND1/MT-ND4/MT-ND3/MT-ND2/ITPR2/GNG2/GNGT1/GRIA4/GNG11/GNG10/GABRA3/GNG12/PRKCA/NDUFA6/NDUFA4/NDUFV1/PLCB2/NDUFA12/NDUFA13/NDUFA4L2/MT-ND6/NDUFS7/NDUFC2/NDUFB6/NDUFA7/NDUFA9/KCNJ5/NDUFB11/NDUFV3/NDUFB5/NDUFS8/NDUFB1/NDUFB9/GNAI2/MAPK9/NDUFS1	3.5937770182302
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	35/1363	142/9376	1.69551424467568	MEF2C/CCL2/ACTB/BMP4/CALM2/ACTG1/TNFRSF1A/BMPR1A/MAP2K5/CYBA/VCAM1/CALML4/PTK2/KEAP1/GSTA4/CDH5/KLF2/NQO1/TP53/AKT2/AKT1/IKBKG/RAC2/MAP2K7/CAV1/KDR/MGST2/MGST1/PRKAA1/GPC1/IKBKB/GSTM4/MAPK9/PIK3R2/SUMO1	3.44422298711602
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	46/1363	203/9376	1.55877537596363	COL1A1/LAMA2/SPP1/COL1A2/ACTB/COL6A1/HGF/COL6A2/IGF1/ITGB5/EGFR/LAMC1/ACTG1/PDGFC/PRKCA/CCND2/PDGFRA/LAMC3/VTN/PTK2/ITGA9/COL4A1/LAMA4/ARHGAP5/SHC1/MYL12A/AKT2/AKT1/CCND1/RAC2/ITGA6/CAV1/ILK/KDR/PPP1CC/ITGA3/COL6A6/PPP1CA/TNXB/CRKL/VEGFB/COL4A2/ITGA11/MAPK9/MYLK/PIK3R2	3.31944575807631
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	54/1363	250/9376	1.4858517975055	DAB2/WWP1/FOLR2/EPS15/SNX6/SNX2/CLTA/EGFR/DNM1/CLTC/ASAP2/PDGFRA/SNX3/SNF8/ARPC1B/ARF5/AP2S1/EPN2/PLD1/CYTH2/PARD3/RAB4A/SNX12/VPS4A/ARF3/AGAP1/SH3GLB1/GRK2/ZFYVE27/VPS26B/ARPC5L/CAV1/CHMP4A/ARPC3/CHMP5/FGFR3/ARPC4/AP2A1/SH3GLB2/ARFGAP1/VTA1/GRK3/STAMBP/EPS15L1/RBSN/WASHC1/CYTH4/PARD6A/SNX5/RAB5C/FGFR2/WIPF3/AGAP9/IL2RB	3.211216455886
NA	NA	hsa04517	IgSF CAM signaling	62/1363	299/9376	1.42640300144527	MAGI1/SLIT2/UNC5C/ACTB/PTPRD/CADM3/CD28/MTSS1/ANK2/PMP22/NRP1/KIRREL1/LMO7/ACTG1/IL1RAPL1/MYL6/ROBO2/PRKCA/CABLES1/ROBO1/SLIT3/NRCAM/JAM3/MPDZ/ARPC1B/CLMP/PTK2/CDH2/AFDN/PARD3/ITGAL/CSK/TJP1/TUBA1B/CADM2/CD209/MTSS2/MYL12A/AKT2/SPTBN1/NCK1/AKT1/ARPC5L/MYH10/MAP2/KDR/ARPC3/NCK2/ARPC4/TUBB3/SLITRK4/PTPRF/PARD6A/TUBA1A/LRFN5/MYL6B/PTPN6/MAPK9/RASA1/MYLK/MAGI2/PIK3R2	3.09044254682509
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	14/1363	44/9376	2.1887547522177	MAN1A1/MAN1C1/MGAT2/TUSC3/STT3A/FUT8/DDOST/MGAT4B/MAN1B1/OSTC/MAN1A2/ALG12/ALG9/HEXD	3.2596219529324
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	41/1363	184/9376	1.53280806405308	SLIT2/UNC5C/EPHA3/NRP1/SEMA3D/ENAH/ABLIM3/ROBO2/PRKCA/ROBO1/SLIT3/SEMA6D/EFNA5/PTK2/PARD3/NFATC2/EPHA7/EPHB3/MYL12A/NCK1/RAC2/EPHA5/LRRC4/ILK/PPP3CB/NCK2/ARHGEF12/TRPC1/EPHA2/NEO1/EPHA6/SEMA3G/NTNG1/PARD6A/EPHA4/BMP7/GNAI2/CFL2/CFL1/RASA1/PIK3R2	3.0103063012106
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	52/1363	248/9376	1.44235912242918	CD14/ACTB/ACTG1/TNFRSF1A/GAPDH/ACTR1A/DYNC2H1/ARPC1B/EXOC4/CYTH2/DYNLT1/TUBA1B/PIK3CG/MYL12A/AKT2/LY96/AKT1/IKBKG/ARPC5L/NCKAP1/PFN2/STX10/DCTN2/EXOC5/ELMO1/DCTN1/MAP2K7/BAX/DYNC1LI2/EXOC7/DCTN3/ARPC3/ARPC4/TUBB3/VPS33A/TRADD/PFN1/CASP5/DCTN6/VPS39/RPS3/ELMO2/CSE1L/VPS18/DCTN5/CYTH4/TUBA1A/IKBKB/RAB5C/MAPK9/VPS16/LEF1	2.91171596205676
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	26/1363	108/9376	1.65604195538165	MAGOH/NCBP2/NUP54/RAN/ALYREF/SEH1L/THOC7/UBE2I/RAE1/PNN/THOC6/XPOT/DDX19B/NUP214/PYM1/XPO4/POM121/CSE1L/KPNA5/NUP133/IPO4/NUP155/THOC5/NUP160/SUMO1/GLE1	2.82804603292259
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	23/1363	93/9376	1.70124409312159	LAMA2/RARB/LAMC1/SKP2/LAMC3/PTK2/COL4A1/LAMA4/TP53/AKT2/AKT1/CCND1/IKBKG/ITGA6/BAX/ITGA3/CDKN1B/FHIT/APAF1/IKBKB/COL4A2/CDK4/PIK3R2	2.80286712563342
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	48/1363	233/9376	1.41712140916119	COL3A1/DCN/COL1A1/LAMA2/COL1A2/ACTB/COL6A1/NEBL/ANK2/COL6A2/COL5A2/FBLN1/TPM1/ITGB5/PDLIM7/COL5A1/ACTG1/COL11A1/TNNT3/DTNA/ATP1B1/FBLN2/ITGA9/SGCE/COL4A1/ELN/PDLIM4/DMD/TNNT1/FHL1/SPTBN1/DAAM1/TNNT2/MYH10/ITGA6/LBR/LMNB2/ITGA3/SSPN/DIAPH2/COL6A6/BGN/ENO2/FHL2/COL4A2/ITGA11/CKM/SGCB	2.65908411966475
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	17/1363	63/9376	1.85622285108712	PRDM6/SMYD3/KMT5A/SETD1B/SETD1A/PLOD1/KMT5B/CAMKMT/ALDH9A1/SETDB1/ECHS1/DLD/KMT2D/PHYKPL/KMT2A/MECOM/TMLHE	2.81221345773363
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	17/1363	63/9376	1.85622285108712	POLE/POLE4/POLR2E/POLD1/RFC2/POLR2D/POLR2H/PCNA/POLR2M/POLR2F/RFC4/MNAT1/UVSSA/POLR2J3/CETN2/POLR2G/RPA3	2.81221345773363
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	22/1363	89/9376	1.7004130017229	CD36/COL1A1/LAMA2/SPP1/COL1A2/COL6A1/COL6A2/ITGB5/FREM1/LAMC1/LAMC3/VTN/ITGA9/COL4A1/LAMA4/FRAS1/ITGA6/ITGA3/COL6A6/TNXB/COL4A2/ITGA11	2.73808845807671
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	31/1363	140/9376	1.5231946336862	SPP1/MEF2C/ITPR2/GNG2/GNGT1/RYR2/GNG11/GNG10/GNG12/CALM2/RYR1/CALML4/KLF2/PLCB2/PIK3CG/AKT2/PRKAG1/AKT1/CCND1/CCN2/PRKAA1/AGTR1/SPHK2/HDAC5/APLN/RPS6KB2/APLNR/MTOR/GNAI2/PIK3R4/MYLK	2.57229830361602
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	10/1363	31/9376	2.21901403450643	SRP19/SEC61A1/SRP14/SEC11C/SRPRB/TMEM208/GET3/SPCS2/SRP9/SEC61G	2.80372810108112
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	21/1363	86/9376	1.67974201914382	LAMA2/ACTB/RYR2/GJA1/ITGB5/CACNB4/ACTG1/DTNA/CACNA2D3/ITGA9/SGCE/CDH2/CACNA2D1/DMD/ITGA6/ITGA3/SSPN/ITGA11/CTNNA3/LEF1/SGCB	2.61168912462406
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	22/1363	93/9376	1.62727695863805	ACTB/PTPRM/EGFR/LMO7/ACTG1/PTPRB/AFDN/PARD3/CDH5/PDCD10/TJP1/WAS/MYL12A/RAC2/CSNK2A1/ACP1/NLK/PTPRF/ARHGAP29/PTPN6/CTNNA3/LEF1	2.50722107077918
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	19/1363	78/9376	1.67564008503113	ACTB/CLTA/DNM1/CLTC/ACTG1/ARPC1B/PTK2/SHC1/ARPC5L/ELMO1/CAV1/ILK/ARPC3/ARPC4/MAD2L2/ELMO2/CRKL/CTNNA3/PIK3R2	2.47117745450147
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	12/1363	44/9376	1.87607550190089	POLE/POLE4/APEX1/POLD1/RFC2/POLB/LIG3/PCNA/PNKP/RFC4/PARP1/MUTYH	2.40224060774096
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	24/1363	109/9376	1.51462976300255	CD36/TBC1D4/PYGL/TNFRSF1A/SLC27A4/CREB3L1/GFPT2/AKT2/PRKAG1/AKT1/IRS1/MLXIP/PPP1CC/PRKAA1/PTPRF/PPP1CA/RPS6KB2/PTPA/IKBKB/MTOR/SLC2A1/PPP1R3D/MAPK9/PIK3R2	2.22881777031417
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	36/1363	178/9376	1.39124700140965	WNT2/RSPO2/ROR1/PRICKLE1/PRKCA/CCND2/RSPO3/SERPINF1/FRZB/MCC/LRP6/PRICKLE2/NFATC2/ROR2/PLCB2/TP53/MMP7/CCND1/DAAM1/RAC2/CTNNBIP1/CSNK2A1/CSNK1E/NLK/PPP3CB/BAMBI/CCAR2/CBY1/DKK2/DVL2/FZD4/INVS/DVL1/TLE4/MAPK9/LEF1	2.17345331098741
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	9/1363	30/9376	2.06368305209098	PIGP/PIGT/PGAP2/MPPE1/PIGV/PIGF/PIGN/PIGS/PIGC	2.4065560070989
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	9/1363	30/9376	2.06368305209098	FOLR2/ABCG2/IKBKG/SLC46A1/MTHFR/SHMT1/SHMT2/ATIC/IKBKB	2.4065560070989
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	22/1363	99/9376	1.52865411265998	LAMA2/ACTB/RYR2/IGF1/TPM1/ITGB5/CACNB4/ACTG1/DTNA/CACNA2D3/ITGA9/SGCE/CACNA2D1/DMD/PRKAG1/TNNT2/ITGA6/ITGA3/PRKAA1/SSPN/ITGA11/SGCB	2.18082807226013
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	25/1363	116/9376	1.48253092822628	PKM/GAPDH/PGP/PGAM1/MDH2/ACSS1/IDH3B/IDH3A/SUCLA2/HIBCH/PRPS1/PDHA1/PRPS2/GOT2/IDH2/DLAT/SUCLG1/ECHS1/SDHD/DLD/SDHC/SHMT1/SHMT2/G6PD/ENO2	2.15667473684287
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	18/1363	78/9376	1.58744850160844	PABPC4L/C1D/MPHOSPH6/LSM5/EXOSC5/CNOT7/LSM7/CNOT8/LSM1/LSM2/DCPS/ENO2/EXOSC1/EXOSC4/EXOSC8/LSM3/DIS3L/EXOSC2	2.14861362583092
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	34/1363	170/9376	1.37578870139398	ACTB/WNT2/HGF/EGFR/ACTG1/IGF2/PRKCA/SMARCA4/KEAP1/LRP6/BRD7/GSTA4/NQO1/SHC1/TP53/AKT2/AKT1/CCND1/BAX/SMARCD2/MGST2/MGST1/SMARCB1/ARID1A/RPS6KB2/DVL2/FZD4/MTOR/ARID1B/DVL1/CDK4/GSTM4/LEF1/PIK3R2	2.03924163008973
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	41/1363	212/9376	1.3303617159706	MAGI1/ACTB/HGF/IGF1/EGFR/CSF1R/ENAH/CALM2/FGF7/ACTG1/ANGPT1/PDGFC/PRKCA/PDGFRA/EFNA5/CALML4/FGF10/MAGI3/PRKD1/AFDN/PARD3/ITGAL/PLCB2/AKT2/AKT1/RAC2/PFN2/KITLG/KDR/FGFR3/LPAR5/PFN1/EPHA2/CRKL/VEGFB/PARD6A/FGFR2/GNAI2/CSF1/MAGI2/PIK3R2	2.00655513816236
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	31/1363	154/9376	1.38472239426018	MEF2C/ITPR2/ACTB/RYR2/EGFR/CACNB4/CALM2/ACTG1/MYL6/PRKCA/MAP2K5/RYR1/CACNA2D3/GUCY1A2/CALML4/NFATC2/CACNA2D1/PLCB2/PIK3CG/PRKAG1/CCND1/GUCY1A1/KCNJ5/PPP3CB/PPP1CC/PRKAA1/PPP1CA/KCNJ14/GNAI2/MYL6B/MYLK	1.98532340748558
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	44/1363	232/9376	1.30462721683912	TMSB4X/ACTB/ITGB5/EGFR/GNG12/ENAH/FGF7/ACTG1/PDGFC/PDGFRA/ARPC1B/SCIN/PTK2/ITGA9/FGF10/ITGAL/MYL12A/AKT2/AKT1/RAC2/ARPC5L/NCKAP1/PFN2/MYH10/ITGA6/PPP1CC/ARPC3/ITGA3/FGFR3/LPAR5/ARPC4/ARHGEF12/PFN1/ARHGEF1/DIAPH2/PPP1CA/CRKL/FGFR2/CFL2/ITGA11/C9/CFL1/MYLK/PIK3R2	1.93767341679695
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	18/1363	80/9376	1.54776228906823	HGF/IGF1/EGFR/GAS6/PDGFC/PRKCA/PDGFRA/SHC1/AKT2/EIF4E2/AKT1/BAX/KDR/FGFR3/RPS6KB2/FGFR2/MTOR/PIK3R2	2.0292009663929
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	12/1363	48/9376	1.71973587674248	HMGCLL1/HADHB/HIBCH/ACAA1/ALDH9A1/ECHS1/HSD17B10/DLD/ACADM/HIBADH/IVD/BCKDHB	2.06174759326877
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	7/1363	23/9376	2.09359150212128	PMVK/GGPS1/PDSS2/FNTA/RCE1/DHDDS/MVD	2.16560663032048
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	7/1363	23/9376	2.09359150212128	PMS2/POLD1/RFC2/PCNA/RFC4/SSBP1/RPA3	2.16560663032048
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	9/1363	33/9376	1.87607550190089	YKT6/USE1/VTI1B/VAMP2/BET1/STX17/BNIP1/GOSR2/STX7	2.0791763492239
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	16/1363	71/9376	1.55018445227491	PKM/EGFR/PDGFRA/PGAM1/PDHA1/TP53/AKT2/AKT1/IDH2/FGFR3/SIRT6/G6PD/FGFR2/MTOR/SLC2A1/PIK3R2	1.91917816464004
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	9/1363	34/9376	1.82089681066851	POLR2E/POLR2D/POLR3GL/POLR3H/POLR2H/POLR2M/POLR2F/POLR2J3/POLR2G	1.9776256675842
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	44/1363	238/9376	1.27173745507007	GNG2/GNGT1/HGF/GNG11/GNG10/IGF1/EGFR/GNG12/CSF1R/CALM2/FGF7/IGF2/ANGPT1/PDGFC/PRKCA/PDGFRA/RGL1/EFNA5/BDNF/CALML4/FGF10/PLD1/AFDN/SHC1/AKT2/PLAAT3/AKT1/IKBKG/RALGAPA2/RAC2/KITLG/KDR/FGFR3/RGL2/EPHA2/VEGFB/IKBKB/RAB5C/FGFR2/CSF1/MAPK9/RASA1/PIK3R2/ETS1	1.75125101562301
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	21/1363	101/9376	1.43027538263731	COL3A1/COL1A1/CCL2/COL1A2/CYBB/PRKCA/VCAM1/COL4A1/PLCB2/AKT2/AKT1/CCND1/BAX/PIM1/AGTR1/CDKN1B/VEGFB/COL4A2/CDK4/MAPK9/PIK3R2	1.79302449236322
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	38/1363	204/9376	1.28137182972969	DCN/COL1A1/LUM/ITPR2/GPC3/COL1A2/ACTB/WNT2/ANK2/HGF/IGF1/TWIST1/ITGB5/EGFR/ACTG1/IGF2/PRKCA/VTN/CD63/PTK2/TP53/AKT2/AKT1/CCND1/CAV1/KDR/PPP1CC/ARHGEF12/ARHGEF1/PPP1CA/RPS6KB2/ERBB4/GPC1/FZD4/MTOR/NUDT16L1/PTPN6/PIK3R2	1.67571312078885
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	33/1363	174/9376	1.30462721683912	MAN1A1/MAN1C1/PRKN/UBE2J2/SEC61A1/TUSC3/PRKCSH/WFS1/LMAN2/GANAB/LMAN1/UGGT1/STT3A/UBE2D4/ERP29/ERLEC1/TXNDC5/MAP2K7/BAX/BCAP29/EDEM2/UBQLN2/DNAJC10/YOD1/UBXN6/DDOST/MAN1B1/OSTC/MAN1A2/MBTPS1/MAPK9/UBE4B/SEC61G	1.67277761090119
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	21/1363	103/9376	1.40250304511037	COL3A1/COL1A1/COL1A2/COL14A1/COL15A1/COL6A1/COL6A2/COL5A2/COL5A1/COL21A1/DPP4/COL11A1/ATP1B1/SLC1A1/COL4A1/ELN/COL8A2/COL6A6/COL16A1/COL19A1/COL4A2	1.69400094220789
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	32/1363	169/9376	1.30252184747359	WDFY3/RPS27A/OPTN/UBA52/YKT6/GORASP2/AKT2/SH3GLB1/ATG7/AKT1/IRS1/STX17/PRKAA1/WDR45/VPS33A/VPS39/TSC1/SMCR8/ATG14/PPP2CB/RPS6KB2/RAB33B/VPS18/STK11/ATG4C/MTOR/STX7/AMBRA1/PIK3R4/MAPK9/VPS16/PIK3R2	1.63672991194859
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	9/1363	36/9376	1.71973587674248	POLE/POLE4/POLD1/RFC2/RNASEH2C/PCNA/RFC4/SSBP1/RPA3	1.78437840459385
NA	NA	hsa04981	Folate transport and metabolism	8/1363	31/9376	1.77521122760514	FOLR2/ABCG2/SLCO2B1/SLC46A1/MTHFR/SHMT1/SHMT2/MTHFD1	1.78298316638344
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	53/1363	300/9376	1.21528001956469	MEF2C/CD14/HGF/IGF1/EGFR/MKNK1/GNG12/CSF1R/CACNB4/FGF7/IGF2/TNFRSF1A/ANGPT1/PDGFC/PRKCA/MAP2K5/PDGFRA/CACNA2D3/EFNA5/BDNF/FGF10/DUSP9/CACNA2D1/TP53/AKT2/AKT1/RPS6KA4/IKBKG/RAC2/MAP3K13/DUSP6/KITLG/MAP2K7/KDR/NLK/PPP3CB/STMN1/FGFR3/TRADD/EPHA2/MAPKAPK3/MAP4K1/DAXX/CRKL/VEGFB/ERBB4/ECSIT/IKBKB/MECOM/FGFR2/CSF1/MAPK9/RASA1	1.56297885530716
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	15/1363	70/9376	1.47405932292213	CD36/TNFRSF1A/AKT2/PRKAG1/APPL1/AKT1/IKBKG/IRS1/PRKAA1/TRADD/STK11/IKBKB/MTOR/SLC2A1/MAPK9	1.64186022724566
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	21/1363	105/9376	1.37578870139398	LAMA2/ACTB/RYR2/IGF1/TPM1/ITGB5/CACNB4/ACTG1/DTNA/CACNA2D3/ITGA9/SGCE/CACNA2D1/DMD/TNNT2/ADRB1/ITGA6/ITGA3/SSPN/ITGA11/SGCB	1.59702263682068
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	9/1363	37/9376	1.67325652872241	HBA1/HBA2/HBB/PRKCA/VCAM1/LAMA4/PLCB2/APOL1/THOP1	1.69226059812842
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	8/1363	32/9376	1.71973587674248	ACSS1/SUCLA2/HIBCH/ACSS3/SUCLG1/ECHS1/DLD/BCKDHB	1.6819679675611
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1363	12/9376	2.29298116898997	NQO1/VKORC1/COQ2/GGCX	1.84836661232697
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1363	27/9376	1.78342979810331	ELOVL2/FADS1/ACAA1/ELOVL1/ACOT2/FADS2/HACD3	1.68126194547155
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	24/1363	125/9376	1.32075715333822	TNFRSF1A/PRKCA/FCER1G/SGMS1/SPTLC1/PLD1/PPP2R1A/PLCB2/TP53/AKT2/DEGS1/AKT1/RAC2/S1PR1/BAX/S1PR3/TRADD/SPHK2/PPP2CB/GNAI2/S1PR2/MAPK9/PIK3R2/PPP2R5D	1.48892564881846
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	8/1363	33/9376	1.66762266835634	IDH3B/IDH3A/PDHA1/GOT2/IDH2/DLAT/DLD/BCKDHB	1.58445848473149
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	10/1363	44/9376	1.56339625158407	DYNC2H1/CREB3L1/VAMP2/DCTN2/DCTN1/DYNC1LI2/DCTN6/NSF/DCTN5/RAB5C	1.54485926254951
Organismal Systems	Immune system	hsa04611	Platelet activation	24/1363	126/9376	1.31027495370856	COL3A1/COL1A1/ITPR2/PRKG1/COL1A2/ACTB/ACTG1/GUCY1A2/FCER1G/PLCB2/PIK3CG/MYL12A/AKT2/FERMT3/AKT1/ORAI1/GUCY1A1/PPP1CC/ARHGEF12/ARHGEF1/PPP1CA/GNAI2/MYLK/PIK3R2	1.44609598534417
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	29/1363	157/9376	1.27063287708362	CD36/PROS1/ITGB5/GAS6/TIMD4/EPOR/UQCRFS1/PTK2/STAB1/NFATC2/GULP1/ADAM10/VPS8/CH25H/S1PR1/RAB14/ARG2/ELMO1/SCARF1/VPS33A/SPHK2/VPS39/CRKL/VPS18/BSG/RAB5C/SLC2A1/PTPN6/VPS16	1.41034209285769
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/1363	28/9376	1.71973587674248	ELOVL2/HADHB/THEM4/ELOVL1/ECHS1/ACOT2/HACD3	1.57300031684856
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	25/1363	133/9376	1.29303449379134	ITPR2/GNG2/GNGT1/GRIA4/GNG11/GNG10/GNG12/CALM2/PRKCA/CALML4/PPP2R1A/CREB3L1/PLCB2/AKT2/AKT1/SCN1A/KCNJ5/PPP3CB/PPP1CC/LRTOMT/PPP1CA/PPP2CB/GNAI2/MAPK9/PPP2R5D	1.40369930187689
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	29/1363	158/9376	1.26259089684891	CDKN1C/CDC14B/SKP2/HDAC8/CCND2/CDC26/HDAC2/ATM/PPP2R1A/ANAPC15/ORC6/FBXO5/TP53/CCND1/CDC27/ANAPC5/MAD2L2/PCNA/CDKN1B/PRKDC/PPP2CB/E2F4/CCNB1/SMC3/ANAPC16/CDK4/CDKN2C/ANAPC10/PPP2R5D	1.37285873969092
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	14/1363	68/9376	1.4162530749644	CD14/RUNX1T1/CSF1R/AKT2/AKT1/CCND1/IKBKG/DUSP6/PIM1/RPS6KB2/IKBKB/MTOR/LEF1/PIK3R2	1.42075671895218
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	24/1363	128/9376	1.28980190755686	ENPP1/PDE4D/PDE3A/PDE9A/GUCY1A2/IMPDH2/DGUOK/AK1/NME1/NUDT9/PRPS1/PRPS2/ADPRM/GUCY1A1/PDE8B/NTPCR/NME7/FHIT/ATIC/PDE1C/ITPA/ENTPD6/GUK1/HDDC3	1.36150207895106
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	22/1363	116/9376	1.30462721683912	ACTB/CYBB/ACTG1/PRKCA/JAM3/CYBA/VCAM1/PTK2/NCF4/CD99/AFDN/ITGAL/CDH5/ARHGAP5/MYL12A/RAC2/TXK/GNAI2/CTNNA3/CD99L2/CLDN5/PIK3R2	1.36153308374797
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	19/1363	98/9376	1.33367272073907	PLPP3/ASAP2/PRKCA/ARPC1B/SCIN/PLD1/WAS/AKT2/AKT1/RAC2/ARPC5L/ARPC3/ARPC4/SPHK2/CRKL/RPS6KB2/CFL2/CFL1/PIK3R2	1.36943855589932
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	26/1363	142/9376	1.25952486747337	WWP1/SKP2/PRKN/UBE2J2/RPS27A/UBA52/UBE2L3/CDC26/KEAP1/RNF7/UBE2I/ANAPC15/UBE2D4/UBA2/ELOB/CDC27/ANAPC5/CDC34/UBA3/TRIM32/PRPF19/PIAS2/ANAPC16/PIAS3/UBE4B/ANAPC10	1.2851807437773
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	6/1363	24/9376	1.71973587674248	NDST2/B3GALT6/EXT2/HS3ST3A1/HS2ST1/HS6ST3	1.45600383230026
Genetic Information Processing	Transcription	hsa03040	Spliceosome	42/1363	243/9376	1.18895319873554	BUD31/MAGOH/NCBP2/SF3B5/ALYREF/SF3B3/SNRPB2/SNRPD2/TXNL4A/THOC7/PHF5A/SF3A1/PRPF8/SF3B4/U2AF2/SRSF1/SNRPA1/DHX16/SNRNP200/THOC6/SNRNP70/CDC40/SNRPD1/SNRNP27/LSM5/RBMX2/SF1/LSM7/DDX46/LSM2/PRPF31/CRNKL1/U2AF1/PRPF19/SNRPF/PPIH/SRSF8/SNRPG/THOC5/LSM3/BUD13/SNRPC	1.23079762937383
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/1363	70/9376	1.37578870139398	LAMA2/ACTB/CD28/EIF4G3/ACTG1/DTNA/SGCE/ITGAL/DMD/CCND1/RAC2/CAV1/SSPN/SGCB	1.30150909988207
Human Diseases	Cancer: specific types	hsa05214	Glioma	15/1363	76/9376	1.35768621848091	IGF1/EGFR/CALM2/PRKCA/PDGFRA/CALML4/SHC1/TP53/AKT2/AKT1/CCND1/BAX/MTOR/CDK4/PIK3R2	1.29122975063472
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	9/1363	41/9376	1.51001198933486	ATM/RAD51B/POLD1/BABAM1/ABRAXAS1/PALB2/SSBP1/BRCC3/RPA3	1.34974319806831
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	35/1363	200/9376	1.20381511371974	ACTB/ACTG1/TNFRSF1A/GAPDH/ARPC1B/CYTH2/MYO1B/TJP1/TUBA1B/ABCF2/NCK1/IKBKG/ARPC5L/NCKAP1/MYH10/BAX/ARPC3/LPAR5/NCK2/ARPC4/TUBB3/TRADD/ARHGEF11/ARHGEF12/ARHGEF1/RPS3/MYO1C/MYO5B/CYTH4/TUBA1A/IKBKB/WIPF3/PTPN6/MAPK9/CLDN5	1.20160209179989
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	25/1363	138/9376	1.24618541792933	PYGL/MKNK1/CALM2/CALML4/SHC1/AKT2/PRKAG1/EIF4E2/AKT1/IRS1/EXOC7/PPP1CC/PRKAA1/PTPRF/TSC1/PPP1CA/CRKL/PHKB/RPS6KB2/IKBKB/MTOR/PPP1R3D/MAPK9/PPP1R3F/PIK3R2	1.20156946760159
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	25/1363	138/9376	1.24618541792933	CCL2/ACTB/ACTG1/ARPC1B/PTK2/NFATC2/WAS/AKT2/AKT1/IKBKG/RAC2/ARPC5L/PKN2/ELMO1/MAP2K7/ARPC3/ARPC4/ARHGEF12/ARHGEF1/ELMO2/CRKL/IKBKB/WIPF3/MAPK9/PIK3R2	1.20156946760159
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	17/1363	89/9376	1.31395550133133	ITPR2/PRKG1/GJA1/EGFR/PDGFC/PRKCA/MAP2K5/PDGFRA/GUCY1A2/TJP1/TUBA1B/PLCB2/ADRB1/GUCY1A1/TUBB3/TUBA1A/GNAI2	1.22733006444832
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	16/1363	83/9376	1.32606139893396	HMGCLL1/GSTK1/PMVK/ACAA1/IDH2/PXMP2/PEX16/PEX26/ECH1/PEX10/ECI2/AGPS/ABCD3/NUDT12/PEX7/PEX14	1.23054205254931
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	15/1363	77/9376	1.34005392992921	EGFR/PLD1/TP53/AKT2/AKT1/CCND1/IKBKG/RAC2/BAX/RPS6KB2/IKBKB/MTOR/CDK4/MAPK9/PIK3R2	1.23569426689265
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	28/1363	157/9376	1.22681795028763	BMP5/ACTB/WNT2/BMP4/ACTG1/YAP1/BMPR1A/CCND2/PPP2R1A/PARD3/LATS1/GLI2/DLG1/CCND1/CCN2/CSNK1E/PPP1CC/NF2/PPP1CA/PPP2CB/DLG4/PARD6A/DVL2/FZD4/BMP7/DVL1/CTNNA3/LEF1	1.18201050128699
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	24/1363	133/9376	1.24131311403968	IGF1/EGFR/SKP2/CCND2/ATM/KLF2/AKT2/PRKAG1/AKT1/PRMT1/CCND1/IRS1/S1PR1/CSNK1E/NLK/PRKAA1/HOMER3/CDKN1B/STK11/CCNB1/IKBKB/MAPK9/HOMER2/PIK3R2	1.15594258317058
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/1363	31/9376	1.5533098241545	PGP/MDH2/ACSS1/GRHPR/DLD/SHMT1/SHMT2	1.27261069903461
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	18/1363	97/9376	1.27650498067483	PRKG1/GNG2/GNGT1/RYR2/GRIA4/GRIN2C/GNG11/GNG10/GNG12/CALM2/PRKCA/RYR1/GUCY1A2/CALML4/PLCB2/GUCY1A1/KCNJ5/GNAI2	1.1289487658946
Human Diseases	Cancer: specific types	hsa05218	Melanoma	14/1363	73/9376	1.31924943969286	HGF/IGF1/EGFR/FGF7/PDGFC/PDGFRA/FGF10/TP53/AKT2/AKT1/CCND1/BAX/CDK4/PIK3R2	1.12931749996791
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	21/1363	116/9376	1.24532597971007	ITPR2/GNG2/GNGT1/GRIA4/GRIN2C/GNG11/GNG10/GNG12/PRKCA/PLD1/SLC1A1/PLCB2/GRK2/PPP3CB/HOMER3/TRPC1/GRK3/DLG4/GRIK2/GNAI2/HOMER2	1.09648586604967
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	55/1363	333/9376	1.13616184049053	MAGI1/COL1A1/LAMA2/SPP1/RBPJ/COL1A2/WNT2/COL6A1/PKM/COL6A2/ITGB5/EGFR/LAMC1/TNFRSF1A/CCND2/LAMC3/VTN/HDAC2/PTK2/ITGA9/ATM/COL4A1/LAMA4/PPP2R1A/PARD3/MAML2/CREB3L1/TP53/DLG1/AKT2/AKT1/CCND1/IKBKG/ITGA6/BAX/ITGA3/TRADD/CDKN1B/TSC1/COL6A6/PPP2CB/TNXB/RPS6KB2/PARD6A/DVL2/IKBKB/COL4A2/FZD4/MTOR/ATP6V1C2/ITGA11/DVL1/CDK4/PIK3R2/PPP2R5D	1.04341544061876
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	20/1363	110/9376	1.25071700126726	TIMP1/IGF1/EGFR/MKNK1/CYBB/ANGPT1/PRKCA/GAPDH/PDHA1/AKT2/EIF4E2/AKT1/ELOB/CDKN1B/LTBR/RPS6KB2/ENO2/MTOR/SLC2A1/PIK3R2	1.09086240358025
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	20/1363	110/9376	1.25071700126726	DCN/BMP5/PITX2/BMP4/BMPR1A/THSD4/HDAC2/PPP2R1A/FST/IGSF1/SMAD9/BAMBI/HFE/PPP2CB/NEO1/E2F4/FMOD/RPS6KB2/BMP7/LRRC32	1.09086240358025
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	38/1363	224/9376	1.16696363064668	NRP1/TNFRSF1A/CCND2/SLC25A4/CDC26/RAN/ATM/NFATC2/ITGAL/ANAPC15/CREB3L1/TP53/DLG1/AKT2/MMP7/AKT1/CCND1/IKBKG/POLB/CDC27/ANAPC5/BAX/PPP3CB/LTBR/RANBP1/TCF3/IKBKB/ANAPC16/NFYB/VDAC3/SLC2A1/IL2RB/CDK4/MAPK9/CDKN2C/PIK3R2/ETS1/ANAPC10	1.04309503480855
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	16/1363	86/9376	1.27980344315719	EGFR/PRKCA/PTK2/SHC1/AKT2/NCK1/AKT1/MAP2K7/NCK2/CDKN1B/CRKL/RPS6KB2/ERBB4/MTOR/MAPK9/PIK3R2	1.0750543425967
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/1363	50/9376	1.37578870139398	CD36/HBA1/HBA2/HBB/CR1/CCL2/HGF/VCAM1/ITGAL/GYPB	1.09879584790458
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	12/1363	62/9376	1.33140842070386	IGF1/HDAC2/AKT2/PRKAG1/AKT1/EIF4EBP2/IRS1/PRKAA1/CLPB/RPS6KB2/MTOR/PIK3R2	1.07976006703704
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	23/1363	130/9376	1.21704385123314	COL3A1/COL1A1/COL1A2/GNG2/GNGT1/GNG11/GNG10/EGFR/GNG12/PRKCA/MMP1/COL4A1/CREB3L1/PLCB2/SHC1/AKT2/AKT1/MAP2K7/VEGFB/COL4A2/GNAI2/MAPK9/PIK3R2	1.02772805786917
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	11/1363	56/9376	1.35122104601195	DISP1/CCND2/GLI3/CDON/GLI2/GRK2/CCND1/CSNK1E/GAS1/GRK3/SPOP	1.0871828278518
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	18/1363	99/9376	1.25071700126726	IGF1/EGFR/PTK2/SHC1/TP53/AKT2/AKT1/CCND1/BAX/CDKN1B/GPER1/RPS6KB2/CARM1/MTOR/CDK4/MAPK9/CDKN2C/PIK3R2	1.03426921584962
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	18/1363	99/9376	1.25071700126726	PLPP3/EGFR/PDGFC/PRKCA/PDGFRA/SLC22A3/PLD1/WAS/AKT2/AKT1/RAC2/TSC1/RPS6KB2/MTOR/LYPLA1/DGKQ/MAPK9/PIK3R2	1.03426921584962
Cellular Processes	Cell motility	hsa04814	Motor proteins	33/1363	194/9376	1.17012956561859	ACTB/TPM1/ACTG1/MYL6/TNNT3/ACTR1A/DYNC2H1/KIF26B/MYO7A/MYO1B/DYNLT1/TUBA1B/TNNT1/MYL12A/TNNT2/DNAH8/MYH10/DCTN2/DCTN1/DYNC1LI2/DCTN3/BICDL1/TUBB3/DCTN6/KIF16B/MYO1C/KIF1C/MYO5B/DCTN5/DNAH1/TUBA1A/MYO15B/MYL6B	0.987524794647773
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	34/1363	201/9376	1.16360238426357	MEF2C/CD14/IGFBP3/MAF/TSPAN7/RUNX1T1/IGF1/PROM1/BMP2K/CSF1R/CCND2/ETV1/MLF1/MEIS1/HDAC2/PTK2/ATM/HPGD/LDB1/FLI1/TP53/LYL1/MLLT3/DUSP6/BAX/FUT8/CDKN1B/ETV5/KLF3/HOXA10/KMT2A/TCF3/IL2RB/CDKN2C	0.966986955542319
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	19/1363	106/9376	1.23301817577763	FOLR2/IGF1/EGFR/PDGFC/PDGFRA/CREB3L1/TP53/AKT2/AKT1/CCND1/IKBKG/SLC46A1/CDKN1B/ETV5/IKBKB/FGFR2/MTOR/LEF1/PIK3R2	0.995036148159461
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	14/1363	75/9376	1.28406945463438	IGFBP3/IGF1/CCND2/SIVA1/ATM/CCNG1/TP53I3/TP53/CCND1/BAX/ZMAT3/APAF1/CCNB1/CDK4	1.01865317170511
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	38/1363	227/9376	1.15154120380994	CCL2/ITPR2/GNG2/GNGT1/CCL4L2/GNG11/GNG10/EGFR/GNG12/CALM2/TNFRSF1A/PRKCA/PDGFRA/CALML4/PTK2/NFATC2/CREB3L1/PLCB2/TP53/AKT2/AKT1/CCND1/IKBKG/RAC2/BAX/PPP3CB/TRADD/ARHGEF11/ARHGEF12/ARHGEF1/TSC1/CRKL/RPS6KB2/IKBKB/MTOR/GNAI2/CDK4/PIK3R2	0.953219333827174
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	42/1363	253/9376	1.14195900115706	ITPR2/CD14/ACTB/EGFR/ACTG1/TNFRSF1A/UBE2V1/RPS27A/UBA52/ARPC1B/PTK2/ATM/CYTH2/PLCB2/MYL12A/TP53/AKT2/UBE2D4/AKT1/IKBKG/ARPC5L/PFN2/ELMO1/BAX/RBCK1/ILK/ARPC3/ARPC4/TRADD/PFN1/ELMO2/ATG14/CRKL/U2AF1/RPS6KB2/CYTH4/IKBKB/MTOR/PIK3R4/MAPK9/SHARPIN/PIK3R2	0.944039905696786
Organismal Systems	Endocrine system	hsa04924	Renin secretion	13/1363	69/9376	1.29603283464651	ITPR2/PDE3A/CALM2/GUCY1A2/CALML4/PLCB2/ADRB1/ORAI1/GUCY1A1/PPP3CB/AGTR1/PDE1C/GNAI2	1.01787762289305
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	11/1363	57/9376	1.32751541362577	ELOVL2/FADS1/HADHB/ACAA1/ELOVL1/ECHS1/ACADM/HSD17B8/FADS2/HACD3/CBR4	1.02287016286566
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	14/1363	77/9376	1.25071700126726	HDAC2/SHC1/TP53/AKT2/AKT1/CCND1/IKBKG/BAX/CDKN1B/CRKL/IKBKB/MECOM/CDK4/PIK3R2	0.911060081390523
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	28/1363	166/9376	1.16030372406722	MEF2C/ITPR2/PRKG1/PDE3A/CALM2/SLC25A4/ATP1B1/GATA4/GUCY1A2/CALML4/NFATC2/CREB3L1/PLCB2/PIK3CG/AKT2/AKT1/IRS1/ADRB1/GUCY1A1/PPP3CB/PPP1CC/AGTR1/PPP1CA/ATP2B4/KCNMB2/VDAC3/GNAI2/MYLK	0.859416792665816
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	12/1363	65/9376	1.26995880128675	SPP1/ITPR2/PRKCA/CGA/KISS1/PLCB2/AKT2/AKT1/KCNJ5/TRPC1/GPER1/PIK3R2	0.900724551724403
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	16/1363	90/9376	1.22292329012799	IGF1/CREB3L1/TP53/AKT2/PRKAG1/APPL1/EIF4E2/AKT1/IRS1/BAX/PRKAA1/TSC1/RPS6KB2/STK11/MTOR/PIK3R2	0.876391898032141
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	11/1363	59/9376	1.28251489112999	HPGDS/GSTA4/GSTK1/GPX8/IDH2/GPX4/MGST2/MGST1/GSS/G6PD/GSTM4	0.897770430025598
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	21/1363	122/9376	1.18408043972433	ACTB/TBC1D4/BMP4/ACTG1/PRKCA/ATP1B1/GATA4/HDAC2/MED14/PLCB2/TP53/AKT2/AKT1/CCND1/NCOA2/NCOA1/MTOR/SLC2A1/MED30/THRA/PIK3R2	0.844031792312736
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	18/1363	103/9376	1.20214546723746	COL3A1/COL1A1/LAMA2/COL1A2/CD14/LAMC1/PRKCA/LAMC3/PTK2/COL4A1/LAMA4/PLCB2/ARG2/GNA14/RAB5C/COL4A2/C9/PIK3R2	0.850762785830387
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/1363	53/9376	1.29791386923961	CLTA/DNM1/CLTC/PRKCA/ATP1B1/AP2S1/PLCB2/AP2A1/ATP2B4/PTH1R	0.896988364441301
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	9/1363	47/9376	1.31724450133467	PKM/MDH2/ACSS1/PDHA1/DLAT/GRHPR/ALDH9A1/DLD/GLO1	0.899210730019356
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	25/1363	149/9376	1.15418515217616	PLPP3/EGFR/DNM1/PDGFC/PRKCA/PDGFRA/FCER1G/PLD1/CYTH2/PTGFR/PLCB2/SHC1/PIK3CG/AKT2/AKT1/KITLG/LPAR5/AGTR1/SPHK2/TSC1/CYTH4/MTOR/DGKQ/LPAR6/PIK3R2	0.782422664848546
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	11/1363	60/9376	1.26113964294448	PRKCA/PTK2/NFATC2/AKT2/AKT1/RAC2/KDR/PPP3CB/MAPKAPK3/SPHK2/PIK3R2	0.83689251951344
Organismal Systems	Nervous system	hsa04730	Long-term depression	11/1363	60/9376	1.26113964294448	ITPR2/PRKG1/IGF1/PRKCA/RYR1/GUCY1A2/PPP2R1A/PLCB2/GUCY1A1/PPP2CB/GNAI2	0.83689251951344
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	35/1363	214/9376	1.12506085394368	ITPR2/GNG2/GNGT1/GNG11/GNG10/GNG12/CALM2/TNFRSF1A/PRKCA/CALML4/PTK2/ATM/RNF7/NFATC2/AKT2/AKT1/IKBKG/RAC2/APOBEC3G/ELOB/MAP2K7/BAX/PPP3CB/TRADD/CRKL/APOBEC3C/RPS6KB2/CCNB1/IKBKB/MTOR/GNAI2/CFL2/MAPK9/CFL1/PIK3R2	0.763254067705024
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	20/1363	117/9376	1.17588777896922	ACTB/ACTG1/SMARCA1/SMARCA4/HDAC2/BRD7/RBBP7/TFPT/INO80C/MBD3/MTA3/BAZ2B/BRD9/SMARCD2/MCRS1/RSF1/SMARCB1/BCL7C/ARID1A/ARID1B	0.789555291439748
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	13/1363	73/9376	1.22501733685766	BICD1/FEZ1/SUPT4H1/RAN/NELFCD/VPS4A/APOBEC3G/MLLT3/CHMP4A/SMARCB1/PSIP1/APOBEC3C/PIN1	0.795979521699403
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	23/1363	137/9376	1.15485912890736	ITPR2/CTSC/ACTB/ACTG1/TNFRSF1A/ATM/TUBA1B/TP53/AKT2/AKT1/IKBKG/BAX/LMNB2/CTSO/TRADD/DAXX/APAF1/TUBA1A/IKBKB/PARP1/MAPK9/PIK3R2/HTRA2	0.753044440786227
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/1363	42/9376	1.31027495370856	CYBB/SLC40A1/TP53/ATG7/NCOA4/GPX4/GSS/VDAC3	0.831138616734455
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/1363	18/9376	1.52865411265998	FUCA1/MAN2C1/NEU1/HEXD	0.925874966649996
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1363	18/9376	1.52865411265998	ZNF76/MMADHC/MMAA/MMAB	0.925874966649996
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	26/1363	158/9376	1.13197804545075	WNT2/IGF1/SKP2/TNFRSF1A/PRKCA/MIOS/LRP6/SEH1L/AKT2/PRR5/EIF4E2/AKT1/IRS1/PRKAA1/SLC38A9/TSC1/RPS6KB2/STK11/DVL2/IKBKB/FZD4/MTOR/TTI1/ATP6V1C2/DVL1/PIK3R2	0.689998074261631
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	8/1363	43/9376	1.27980344315719	ECI1/HADHB/ACAA1/CYP2U1/ALDH9A1/ECHS1/ACADM/ECI2	0.758425006708576
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	18/1363	107/9376	1.15720544977064	ITPR2/PKM/PYGL/CALM2/PGAM1/CALML4/CREB3L1/PLCB2/PDHA1/AKT2/PRKAG1/AKT1/PRMT1/PPP3CB/PRKAA1/PHKB/PPP4C/SLC2A1	0.674495474234932
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	13/1363	75/9376	1.19235020787479	PKM/GAPDH/PGAM1/IDH3B/IDH3A/PRPS1/PRPS2/GOT2/IDH2/ARG2/SHMT1/SHMT2/ENO2	0.689754375675391
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1363	13/9376	1.58744850160844	PRKDC/LIG4/XRCC5	0.874117791081835
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/1363	19/9376	1.4481986330463	PDHA1/DLAT/DLD/BCKDHB	0.80651975243204
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	25/1363	154/9376	1.11671160827434	RYR2/TPM1/CACNB4/CALM2/PRKCA/ATP1B1/CACNA2D3/CALML4/PPP2R1A/CACNA2D1/CREB3L1/PLCB2/PIK3CG/AKT2/AKT1/TNNT2/ADRB1/PPP1CC/AGTR1/SCN1B/PPP1CA/PPP2CB/ATP2B4/GNAI2/PPP2R5D	0.602279179193373
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/1363	51/9376	1.21393120711234	ACTB/ACTG1/PRKCA/SEC61A1/CFTR/TJP1/ATP6V1C2/KDELR2/SEC61G	0.631787172926473
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	17/1363	103/9376	1.13535960794649	MAGOH/NCBP2/ALYREF/PPP2R1A/PABPC4L/NUDT21/PNN/DDX19B/PYM1/CSTF3/PPP1CC/CPSF2/PPP1CA/PPP2CB/CLP1/PPP2R5D/GLE1	0.569683400371219
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	8/1363	45/9376	1.22292329012799	ABCG2/CFTR/ABCA9/ABCA6/ABCB9/ABCB10/ABCD3/ABCB6	0.618206548486974
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/1363	20/9376	1.37578870139398	SQLE/EBP/LBR/NSDHL	0.693824456755383
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	31/1363	196/9376	1.08799616691871	ITPR2/GNG2/GNGT1/GNG11/GNG10/IL6ST/CD200R1/GNG12/CALM2/TNFRSF1A/RPS27A/UBA52/CALML4/NFATC2/PIK3CG/TP53/AKT2/AKT1/CCND1/IKBKG/MAP2K7/BAX/PPP3CB/TRADD/ATG14/IKBKB/MTOR/CDK4/MAPK9/LEF1/PIK3R2	0.513459796888826
NA	NA	hsa04519	Cadherin signaling	62/1363	404/9376	1.05567944908944	CDH11/ACTB/WNT2/PCDH12/GJA1/GABRA3/PRICKLE1/PCDH10/EGFR/ENAH/ACTG1/YAP1/PDGFRA/KRT18/MPDZ/KRT19/ARPC1B/PCDH18/PTK2/CDH2/KRT1/LRP6/PRICKLE2/AFDN/MYO7A/LATS1/CDH5/MYO1B/TJP1/APH1A/ADAM10/KRT8/DAAM1/IKBKG/RAC2/ARPC5L/AMOTL2/NCKAP1/FAT4/RERE/KDR/PPP1CC/NF2/ARPC3/ARPC4/SCN1B/MYO1C/PPP1CA/APH1B/PSENEN/KRT7/AMOTL1/KRT10/DVL2/IKBKB/FZD4/PCDH15/DVL1/MAPK9/CTNNA3/LEF1/TMC8	0.471820682427087
Human Diseases	Substance dependence	hsa05032	Morphine addiction	15/1363	91/9376	1.13389178686317	GNG2/GNGT1/PDE4D/GNG11/GNG10/GABRA3/PDE3A/GNG12/PRKCA/GRK2/KCNJ5/PDE8B/GRK3/PDE1C/GNAI2	0.529321670438217
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	25/1363	157/9376	1.09537316989967	ITPR2/IGFBP3/ZFP36L1/CALM2/CCND2/SLC25A4/GATA4/CALML4/ATM/NFATC2/TP53/AKT2/AKT1/CCND1/PPP3CB/PPP1CC/TSC1/PPP1CA/E2F4/CCNB1/VDAC3/MTOR/CDK4/PIK3R2/ETS1	0.497015726574907
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/1363	59/9376	1.16592262829999	PRKG1/CGA/AKT2/PLAAT3/AKT1/IRS1/ABHD5/ADRB1/GNAI2/PIK3R2	0.527265762041972
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/1363	59/9376	1.16592262829999	EGFR/TP53/AKT2/AKT1/CCND1/BAX/ILK/CTNNA3/LEF1/PIK3R2	0.527265762041972
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	17/1363	105/9376	1.11373371065227	PRKN/RPS27A/OPTN/UBA52/MON1B/TP53/TOMM7/CSNK2A1/PGAM5/MTX2/TOMM40/MUL1/MTX1/CCZ1/RAB5C/AMBRA1/MAPK9	0.483344256513085
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1363	21/9376	1.31027495370856	ENPP1/VNN2/PANK3/PPCS	0.587043745972818
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	12/1363	73/9376	1.13078523402245	HGF/RARB/EGFR/PRKCA/TP53/AKT2/AKT1/CCND1/BAX/FHIT/CDK4/PIK3R2	0.462641543430896
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1363	15/9376	1.37578870139398	AK1/ACP1/NTPCR	0.600709112350931
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/1363	41/9376	1.17445376948267	PGAM1/GAMT/ALAS2/GRHPR/DLD/SHMT1/SHMT2	0.461690692886844
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	19/1363	122/9376	1.0713108740363	CD36/IGF1/PPP2R1A/CFTR/CREB3L1/AKT2/PRKAG1/AKT1/CCND1/IRS1/RAB14/PRKAA1/TSC1/PPP2CB/RPS6KB2/STK11/MTOR/PIK3R2/PPP2R5D	0.326969258191585
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	10/1363	62/9376	1.10950701725321	RBPJ/HDAC2/MAML2/APH1A/APH1B/PSENEN/DVL2/DVL1/TLE4/DTX4	0.35678424838823
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1363	29/9376	1.18602474258102	YAP1/LATS1/CSNK1E/FAT4/NF2	0.413780085098102
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	23/1363	150/9376	1.05477133773539	WNT2/HGF/RARB/EGFR/FGF7/FGF10/LRP6/SHC1/TP53/AKT2/AKT1/CCND1/BAX/CDKN1B/RPS6KB2/DVL2/FGFR2/FZD4/MTOR/DVL1/CTNNA3/LEF1/PIK3R2	0.278886985109571
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/1363	76/9376	1.08614897478472	ITPR2/ACTB/CALM2/ACTG1/PRKCA/ATP1B1/CALML4/CFTR/PLCB2/KCNK10/GNAI2/MYLK	0.310993584547777
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/1363	63/9376	1.09189579475713	WNT2/BMP4/GLI3/GLI2/TP53/BAX/DVL2/FZD4/DVL1/LEF1	0.301826318226623
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/1363	23/9376	1.19633800121216	LARGE1/RXYLT1/POMT2/B4GAT1	0.388802287128388
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	29/1363	193/9376	1.03362363576232	CXCL14/CCL2/GNG2/GNGT1/CCL4L2/GNG11/GNG10/GNG12/CCL13/PTK2/PARD3/WAS/PLCB2/SHC1/PIK3CG/AKT2/GRK2/AKT1/IKBKG/RAC2/ELMO1/PPBP/CXCL13/CRKL/GRK3/IKBKB/GNAI2/CCL23/PIK3R2	0.194655656989281
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	16/1363	105/9376	1.04821996296684	EDA/CD14/CCL4L2/TNFRSF1A/CCL13/VCAM1/ATM/UBE2I/LY96/IKBKG/CSNK2A1/TRADD/LTBR/TNFRSF11A/IKBKB/PARP1	0.204924661436186
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	7/1363	44/9376	1.09437737610885	TAF10/TAF12/TAF9B/TAF4/MNAT1/TAF1/GTF2A2	0.258787244762349
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	13/1363	85/9376	1.05207371283069	ENPP1/IMPDH2/DGUOK/AK1/NME1/DCTD/NTPCR/NME7/ITPA/DCTPP1/ENTPD6/NT5C3B/GUK1	0.198899078633519
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	23/1363	154/9376	1.02737467961239	PANK3/AK1/ALAS2/NME1/PPCS/NQO1/VKORC1/COQ2/GMPPB/UROD/DLD/GGCX/SHMT1/GSS/SHMT2/NME7/FLAD1/UROS/MOCS2/MTHFD1/MMAB/NADK2/NMNAT1	0.141264436429305
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	37/1363	250/9376	1.01808363903155	LGMN/CTSC/CLTA/OSBPL6/CLTC/CD63/OSTM1/AP2S1/HYAL2/BORCS7/KXD1/VPS26B/AP5M1/MEAK7/STX17/FUCA1/CTSO/TLR7/VPS33A/NAGPA/ABCB9/VPS39/SLC29A3/SLC38A9/AP2A1/BLOC1S5/VPS18/BORCS8/ARSA/MTOR/TTI1/ATP6V1C2/NEU1/NCOA7/BLOC1S3/VPS16/ROGDI	0.119523030559029
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/1363	38/9376	1.08614897478472	UXS1/GFPT2/GMPPB/GALK2/GALK1/GNPDA2	0.219457775008461
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/1363	38/9376	1.08614897478472	ENPP1/SIRT2/SIRT6/NADK2/NUDT12/NMNAT1	0.219457775008461
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1363	38/9376	1.08614897478472	IGF1/NR3C2/PRKCA/ATP1B1/IRS1/PIK3R2	0.219457775008461
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	20/1363	134/9376	1.02670798611491	ITPR2/PRKG1/CALD1/CALM2/MYL6/PRKCA/GUCY1A2/CALML4/PLCB2/MYH10/GUCY1A1/PPP1CC/AGTR1/ARHGEF11/ARHGEF12/ARHGEF1/PPP1CA/KCNMB2/MYL6B/MYLK	0.128424106729677
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	23/1363	155/9376	1.02074645587296	CD36/CD14/ACTB/MRC1/COLEC12/ITGB5/CYBB/ACTG1/DYNC2H1/SEC61A1/CYBA/NCF4/MRC2/TUBA1B/CD209/DYNC1LI2/TUBB3/TUBA1A/RAB5C/ATP6V1C2/STX7/STX12/SEC61G	0.107412976022579
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	13/1363	87/9376	1.02788811023688	EGFR/TP53/AKT2/APPL1/AKT1/CCND1/RAC2/BAX/RPS6KB2/MTOR/MAPK9/LEF1/PIK3R2	0.107778026255815
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/1363	32/9376	1.07483492296405	ATG7/PPP2CB/ATG4C/MTOR/PIK3R4	0.174883519562928
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/1363	32/9376	1.07483492296405	TNFRSF1A/BAX/APAF1/MAPK9/HTRA2	0.174883519562928
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/1363	39/9376	1.0582990010723	MTHFR/DLD/SHMT1/SHMT2/ATIC/MTHFD1	0.150461619562116
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/1363	46/9376	1.04679575106064	BLVRB/ALAS2/FXN/UROD/BLVRA/UROS/MMAB	0.131214101437329
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	18/1363	122/9376	1.01492609119228	CD28/PPP2R1A/NFATC2/DLG1/AKT2/NCK1/AKT1/IKBKG/MAP2K7/PPP3CB/NCK2/PPP2CB/IKBKB/CDK4/PTPN6/MAPK9/PIK3R2/PPP2R5D	0.0684379911310098
Human Diseases	Infectious disease: viral	hsa05162	Measles	20/1363	136/9376	1.01160933926028	CD28/CCND2/CD209/TP53/AKT2/AKT1/CCND1/IKBKG/CSNK2A1/BAX/TLR7/TRADD/CDKN1B/RACK1/APAF1/IKBKB/IL2RB/CDK4/MAPK9/PIK3R2	0.0562440992725108
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	11/1363	75/9376	1.00891171435559	ATM/GSTA4/TP53/AKT2/AKT1/BAX/MGST2/MGST1/APAF1/GSTM4/PIK3R2	0.0319567836159428
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	20/1363	138/9376	0.996948334343467	ITPR2/IGF1/CALM2/CDC26/CALML4/PPP2R1A/ANAPC15/FBXO5/CDC27/ANAPC5/PPP3CB/PPP1CC/MAD2L2/PPP1CA/PPP2CB/CCNB1/SMC3/ANAPC16/ANAPC10/PPP2R5D	-0.0148944170173044
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	13/1363	90/9376	0.993625173228988	CD28/EGFR/NFATC2/AKT2/AKT1/IKBKG/CSNK2A1/PPP3CB/RPS6KB2/IKBKB/MTOR/PTPN6/PIK3R2	-0.0250617444694336
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	10/1363	69/9376	0.996948334343467	GRIA4/GRIN2C/CALM2/PRKCA/CALML4/HDAC2/CREB3L1/PPP3CB/PPP1CC/PPP1CA	-0.0104928299188355
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/1363	41/9376	1.00667465955657	EGFR/MMP1/TP53/CCND1/FGFR3/CDK4	0.0176644402961116
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/1363	34/9376	1.01160933926028	BHLHE41/PRKAG1/CSNK1E/FBXL3/PRKAA1	0.0279681039156798
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	15/1363	105/9376	0.982706215281417	ITPR2/CALM2/FCER1G/CALML4/NFATC2/CD209/AKT2/AKT1/IKBKG/PPP3CB/ARHGEF12/CARD9/IKBKB/MAPK9/PIK3R2	-0.0734949336407129
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	14/1363	98/9376	0.982706215281417	ITPR2/CALM2/PRKCA/CALML4/CDS1/PLCB2/PIP4P2/INPP4B/MTMR1/MTMR6/OCRL/DGKQ/MTMR2/PIK3R2	-0.0709760615689352
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1363	20/9376	1.03184152604549	GMPPB/CYB5R1/NPL	0.0587894990690817
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	21/1363	148/9376	0.976066308421407	WNT2/IGF1/EGFR/FGF7/FGF10/LRP6/SHC1/TP53/AKT2/AKT1/CCND1/BAX/NCOA1/RPS6KB2/DVL2/FZD4/MTOR/DVL1/CDK4/LEF1/PIK3R2	-0.121038281712934
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	11/1363	78/9376	0.970107417649604	CD14/C4BPB/CALM2/CALML4/C1S/LY96/C2/GNAI2/CFL2/MAPK9/CFL1	-0.10933317486295
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/1363	71/9376	0.96886528267182	CCND2/CGA/SHC1/AKT2/AKT1/CCND1/TNFRSF11A/SOCS5/MAPK9/PIK3R2	-0.108605522041591
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/1363	28/9376	0.982706215281417	PCBD1/QDPR/MOCS2/CBR1	-0.0377959883908567
Organismal Systems	Digestive system	hsa04970	Salivary secretion	13/1363	93/9376	0.961572748286118	ITPR2/PRKG1/CALM2/PRKCA/ATP1B1/GUCY1A2/CALML4/PLCB2/ADRB1/VAMP2/GUCY1A1/PRH1/ATP2B4	-0.153593422909026
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1363	21/9376	0.982706215281417	CHSY3/CSGALNACT1/B3GALT6	-0.0327200376372642
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	17/1363	122/9376	0.958541308348267	ITPR2/IGFBP3/IGF1/CSH1/PRKCA/PTK2/CREB3L1/PLCB2/SHC1/AKT2/AKT1/IRS1/CRKL/MTOR/GNAI2/MAPK9/PIK3R2	-0.190093275929566
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	16/1363	115/9376	0.957070400969728	MEF2C/ITPR2/PDE4D/EGFR/PRKCA/PLD1/LRP6/CREB3L1/PLCB2/MMP16/NACA/ARHGEF11/ARHGEF1/MMP15/GNAI2/PTH1R	-0.191034939394783
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/1363	51/9376	0.94416871664293	ENPP2/PLPP3/PLD4/PLD1/CEPT1/PLAAT3/AGPS	-0.16488238976045
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1363	22/9376	0.938037750950444	HNMT/ALDH9A1/ASPA	-0.119998502221404
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/1363	37/9376	0.92958696040134	UXS1/GFPT2/GMPPB/GALK2/GALK1	-0.176986345358408
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/1363	37/9376	0.92958696040134	TP53/CCND1/NCOA4/BAX/LEF1	-0.176986345358408
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	9/1363	67/9376	0.924037187503422	PKM/GAPDH/PGAM1/ACSS1/PDHA1/DLAT/ALDH9A1/DLD/ENO2	-0.257349255924236
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	9/1363	67/9376	0.924037187503422	ITPR2/GRIN2C/CALM2/PRKCA/CALML4/PLCB2/PPP3CB/PPP1CC/PPP1CA	-0.257349255924236
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	35/1363	254/9376	0.947885916314753	ITPR2/RYR2/GRIN2C/HGF/EGFR/HRH1/CALM2/FGF7/PDGFC/PRKCA/PDGFRA/SLC25A4/RYR1/CALML4/FGF10/NFATC2/PTGFR/PLCB2/ADRB1/ORAI1/KDR/PPP3CB/FGFR3/AGTR1/SPHK2/PHKB/ATP2B4/VEGFB/GNA14/TRDN/ERBB4/PDE1C/FGFR2/VDAC3/MYLK	-0.347266528139469
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1363	15/9376	0.917192467595989	ST6GALNAC6/ST3GAL5	-0.13237023652351
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1363	23/9376	0.89725350090912	ENPEP/AGTR1/THOP1	-0.203465827268975
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	28/1363	205/9376	0.939563015586135	RBPJ/SKP2/PSMD2/CCND2/PSMC4/PSMC3/HDAC2/PSMC5/ITGAL/PSMC6/PSMD3/PSMD8/TP53/AKT2/AKT1/CCND1/IKBKG/PSMC2/MAP2K7/BAX/TRADD/PSMD13/CDKN1B/APAF1/IKBKB/CDK4/MAPK9/PIK3R2	-0.360833927171335
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	16/1363	119/9376	0.924899967323687	CCL2/TNFRSF1A/VCAM1/CREB3L1/AKT2/AKT1/RPS6KA4/IKBKG/MAP2K7/TRADD/PGAM5/IKBKB/CSF1/MAPK9/RHBDF1/PIK3R2	-0.340027834445223
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	11/1363	83/9376	0.911667211767098	MBD5/HDAC2/AUTS2/RING1/RBBP7/SCML2/DCAF7/UBE2D4/SCMH1/CBX6/SFMBT1	-0.333364240277749
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/1363	31/9376	0.88760561380257	PRPS1/PRPS2/RBKS/G6PD	-0.258506703011906
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	16/1363	120/9376	0.917192467595989	CALM2/MAP2K5/BDNF/CALML4/SHC1/TP53/AKT2/AKT1/IRS1/MAP2K7/BAX/MATK/CRKL/IKBKB/MAPK9/PIK3R2	-0.376517171957723
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	19/1363	142/9376	0.920422018538229	ITPR2/CSF1R/TNFRSF1A/LILRB5/CYBA/NCF4/NFATC2/AKT2/AKT1/IKBKG/MAP2K7/PPP3CB/TMEM64/TNFRSF11A/FHL2/IKBKB/CSF1/MAPK9/PIK3R2	-0.394074334375034
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/1363	47/9376	0.878163000889777	PKM/IRS1/IKBKB/MTOR/MAPK9/PIK3R2	-0.345339750420758
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/1363	55/9376	0.875501900887081	PLPP3/SGMS1/SPTLC1/DEGS1/SPHK2/ARSA/NEU1	-0.381899250465313
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	29/1363	216/9376	0.923561859732073	CD36/CCL2/CD14/CALM2/CYBB/TNFRSF1A/PRKCA/CYBA/VCAM1/CALML4/PTK2/NCF4/MMP1/NFATC2/PLCB2/TP53/AKT2/LY96/AKT1/IKBKG/MAP2K7/BAX/PPP3CB/ARHGEF1/APAF1/IKBKB/MIB2/MAPK9/PIK3R2	-0.468732693072495
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	13/1363	100/9376	0.89426265590609	CXCL14/CCL2/CCL4L2/IL6ST/CSF1R/TNFRSF1A/CCL13/PPBP/CXCL13/LTBR/IL2RB/CSF1/CCL23	-0.438413604515625
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	19/1363	144/9376	0.907638379391864	WNT2/IGF1/IL6ST/BMP4/BMPR1A/MEIS1/DUSP9/AKT2/LIFR/AKT1/SETDB1/FGFR3/SMAD9/TCF3/DVL2/FGFR2/FZD4/DVL1/PIK3R2	-0.460639193837462
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/1363	63/9376	0.873516635805704	PTGDS/HPGDS/HPGD/PLAAT3/PTGR1/CYP2U1/GPX4/CBR1	-0.415427150203949
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	15/1363	115/9376	0.89725350090912	ITPR2/GNG2/GNGT1/GNG11/GNG10/GNG12/PRKCA/CREB3L1/PLCB2/PIK3CG/AKT2/AKT1/KCNJ14/GNAI2/PIK3R2	-0.457217669631889
NA	NA	hsa03272	Virion - Hepatitis viruses	6/1363	48/9376	0.85986793837124	EGFR/DPP4/CD63/VPS4A/CHMP4A/CLDN5	-0.401420785233777
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/1363	71/9376	0.871978754404638	EGFR/JAM3/CSK/TJP1/ADAM10/IKBKG/IKBKB/ATP6V1C2/MAPK9	-0.446569469821864
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	21/1363	160/9376	0.902861335289802	PTPRD/CADM3/CD28/PTPRM/NRCAM/JAM3/VCAM1/ITGA9/CDH2/CD99/ITGAL/CDH5/LRRC4/ITGA6/SLITRK4/PTPRF/NEO1/CD34/NTNG1/CD99L2/CLDN5	-0.511112947115046
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	10/1363	79/9376	0.87075234265442	SYT1/CLTA/DNM1/CLTC/AP2S1/SLC1A1/VAMP2/AP2A1/NSF/ATP6V1C2	-0.475774109454449
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1363	17/9376	0.809287471408226	CD209/MYH10	-0.324582391774049
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	18/1363	139/9376	0.8907984397515	ITPR2/EGFR/CALM2/KRT18/KRT19/CALML4/CREB3L1/PLCB2/SHC1/AKT2/AKT1/KCNJ5/NCOA2/NCOA1/GPER1/KRT10/GNAI2/PIK3R2	-0.534942085613248
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	14/1363	110/9376	0.875501900887081	IGF1/CDC26/ANAPC15/AKT2/AKT1/CDC27/ANAPC5/MAD2L2/CCNB1/ANAPC16/GNAI2/MAPK9/PIK3R2/ANAPC10	-0.541687619718782
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1363	26/9376	0.793724250804221	ACAA1/PLAAT3/FADS2	-0.434375214553851
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	11/1363	88/9376	0.85986793837124	F13A1/CR1/C4BPB/PROS1/VTN/C1S/VSIG4/CFI/C2/CD59/C9	-0.544695439175936
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	13/1363	103/9376	0.868216170782611	CCL2/TNFRSF1A/PPP2R1A/PLCB2/AKT2/AKT1/IKBKG/PPP2CB/GNA14/IKBKB/GNAI2/MAPK9/PIK3R2	-0.55463414146545
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	20/1363	155/9376	0.88760561380257	ITPR2/WNT2/EGFR/CREB3L1/PLCB2/CCND1/ORAI1/AIP/AGTR1/PDE8B/CDKN1B/KMT2D/KMT2A/DVL2/FZD4/GNAI2/DVL1/CDK4/LEF1/CDKN2C	-0.581912187008019
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1363	18/9376	0.764327056329991	HSD17B8/CBR4	-0.412753204099482
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	13/1363	104/9376	0.85986793837124	PLPP3/PLD4/SGMS1/PLPP5/PLD1/CDS1/CEPT1/PLAAT3/ADPRM/PEMT/CRLS1/LYPLA1/DGKQ	-0.592657062798018
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	11/1363	89/9376	0.850206500861451	GNG2/GNGT1/GNG11/GNG10/GABRA3/GNG12/PRKCA/SLC12A5/TRAK2/NSF/GNAI2	-0.585580007905748
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	14/1363	112/9376	0.85986793837124	LAMA2/LAMC1/TNFRSF1A/LAMC3/LAMA4/PIK3CG/AKT2/LY96/AKT1/IKBKG/ITGA6/IKBKB/GNAI2/MAPK9	-0.615294799325164
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	7/1363	59/9376	0.81614583980999	ENPP1/NME1/DCTD/NME7/DCTPP1/ENTPD6/NT5C3B	-0.584248241908907
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/1363	75/9376	0.82547322083639	ITPR2/PRKCA/ATP1B1/CGA/CREB3L1/PLCB2/GPX8/ASGR2/TTF1	-0.625840808443505
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/1363	98/9376	0.842319613098357	ITPR2/CALM2/PRKCA/ATP1B1/CALML4/PRKD1/CREB3L1/PLCB2/ORAI1/KCNJ5/AGTR1/ATP2B4	-0.647141908556238
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	18/1363	144/9376	0.85986793837124	CD14/TNFRSF1A/AKT2/PRKAG1/LY96/AKT1/CCND1/IKBKG/IL17RA/MAP2K7/ALDH9A1/C2/PRKAA1/TRADD/ACADM/IKBKB/MAPK9/LEF1	-0.698886826307676
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1363	10/9376	0.687894350696992	SELENBP1	-0.407249488727839
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/1363	76/9376	0.814611731088543	CD36/PLTP/SLC27A4/MMP1/ACAA1/ILK/ACADM/ANGPTL4/FADS2	-0.669242581539165
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	26/1363	205/9376	0.872451371615697	RBPJ/PKM/HDAC9/IL6ST/SKP2/HDAC8/CCND2/SCIN/HDAC2/CREB3L1/TP53/DLG1/CCND1/IKBKG/POLB/BAX/TRADD/CDKN1B/LTBR/HDAC5/MRPS18B/GTF2A2/RANBP1/VDAC3/CDK4/PIK3R2	-0.761518347276557
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/1363	69/9376	0.797558667474773	PRKCA/FCER1G/AKT2/AKT1/RAC2/MAP2K7/MAPK9/PIK3R2	-0.696073131793426
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	12/1363	100/9376	0.82547322083639	CD36/CR1/CD14/CSF1R/EPOR/KITLG/ITGA6/ITGA3/CD34/CD7/CD59/CSF1	-0.723631891771975
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	21/1363	168/9376	0.85986793837124	IL12RB2/IL6ST/EGFR/CSH1/CCND2/PDGFRA/EPOR/OSMR/FHL1/AKT2/LIFR/AKT1/CCND1/PIM1/SOCS5/PIAS2/MTOR/IL2RB/PTPN6/PIAS3/PIK3R2	-0.755867185516024
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/1363	37/9376	0.743669568321072	GFPT2/GOT2/NIT2/ASPA	-0.644298081230115
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1363	29/9376	0.711614845548612	GNGT1/CALM2/CALML4	-0.641463238138619
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	12/1363	101/9376	0.817300218649891	WNT2/CALM2/PRKCA/CALML4/CREB3L1/PLCB2/KITLG/DVL2/FZD4/GNAI2/DVL1/LEF1	-0.761338426340509
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	6/1363	54/9376	0.764327056329991	PMS2/PALB2/CENPS/RPA3/FAAP100/RMI1	-0.716288620618845
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	8/1363	70/9376	0.786164972225134	HPGDS/GSTA4/GSTK1/SULT1A1/MGST2/MGST1/GSTM4/CBR1	-0.740597664299489
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/1363	70/9376	0.786164972225134	HGF/AKT2/AKT1/ELOB/CRKL/SLC2A1/PIK3R2/ETS1	-0.740597664299489
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	24/1363	195/9376	0.846639200857836	CR1/ACTB/HDAC9/CYBB/ACTG1/HDAC8/PRKCA/SLC25A4/CYBA/CLCN5/HDAC2/NCF4/ITGAL/PLCB2/AKT2/ATG7/AKT1/RAC2/CLCN3/TLR7/HDAC5/VDAC3/MTOR/PIK3R2	-0.892529685533709
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/1363	48/9376	0.716556615309367	ATP1B1/PLCB2/AKT2/AKT1/PIK3R2	-0.811948848317536
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	22/1363	181/9376	0.836114680405183	CR1/CD14/MRC1/CALM2/TNFRSF1A/FCER1G/CALML4/MRC2/CD209/AKT2/AKT1/NFYA/BAX/PPP3CB/TRADD/ARHGEF12/SPHK2/APAF1/CARD9/NFYB/RAB5C/MAPK9	-0.918204607662351
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1363	12/9376	0.573245292247493	CD209	-0.610062367790914
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/1363	31/9376	0.665704210351928	HIBCH/ALDH9A1/ECHS1	-0.768879170360743
NA	NA	hsa04081	Hormone signaling	27/1363	219/9376	0.848088925516839	PRKG1/GNG2/GNGT1/GNG11/GNG10/IGF1/CSH1/GNG12/IGF2/BMPR1A/SLC40A1/CGA/EPOR/PLCB2/APPL1/IRS1/ADRB1/VIPR2/AGTR1/SMAD9/GPER1/GNA14/STK11/GNAI2/PTH1R/THRA/PIK3R2	-0.938146970859553
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1363	49/9376	0.701933010915298	GRIN2C/BDNF/CREB3L1/DLG4/GNAI2	-0.862734026263658
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1363	23/9376	0.59816900060608	GOT2/ARG2	-0.795733941666337
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/1363	91/9376	0.755927857908782	LILRB5/NFATC2/AKT2/AKT1/IKBKG/RAC2/PPP3CB/IKBKB/PTPN6/PIK3R2	-0.964903650820507
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/1363	99/9376	0.764327056329991	ITPR2/IGF1/HRH1/CALM2/PRKCA/CALML4/PLCB2/PPP1CC/PPP1CA/MAPK9/PIK3R2	-0.972208782868779
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	9/1363	83/9376	0.745909536900353	CCL4L2/POLR2E/POLR3GL/IKBKG/POLR3H/IL33/POLR2H/POLR2F/IKBKB	-0.958926757408574
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/1363	50/9376	0.687894350696992	GAMT/GOT2/ARG2/ALDH9A1/CKM	-0.912588351617748
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/1363	42/9376	0.655137476854278	INMT/ALDH9A1/ECHS1/DLD	-0.923788907306137
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	12/1363	109/9376	0.757314881501275	SPP1/CD14/CCL4L2/AKT2/LY96/AKT1/IKBKG/MAP2K7/TLR7/IKBKB/MAPK9/PIK3R2	-1.05104862483066
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	10/1363	93/9376	0.739671344835475	IL12RB2/RBPJ/MAF/NFATC2/MAML2/IKBKG/PPP3CB/IKBKB/IL2RB/MAPK9	-1.04053158747176
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/1363	93/9376	0.739671344835475	ITPR2/EGFR/CALM2/PRKCA/CGA/CALML4/PLD1/PLCB2/MAP2K7/MAPK9	-1.04053158747176
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1363	14/9376	0.491353107640708	FUT8	-0.785474498524915
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	21/1363	180/9376	0.802543409146491	CCL2/TNFRSF1A/ALYREF/SRSF1/TP53/AKT2/AKT1/IKBKG/BAX/PPP1CC/TRADD/EIF2B3/TSC1/DAXX/PPP1CA/APAF1/CARD9/IKBKB/SRSF8/MTOR/PIK3R2	-1.10317497247018
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1363	43/9376	0.639901721578597	CD36/PLPP3/SLC27A4/GOT2	-0.976069258283096
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	27/1363	226/9376	0.821820684461008	PDE4D/RYR2/GRIA4/GRIN2C/PDE3A/CALM2/ATP1B1/CGA/BDNF/GLI3/CALML4/PLD1/AFDN/CFTR/CREB3L1/AKT2/AKT1/RAC2/ADRB1/VIPR2/ORAI1/PPP1CC/PPP1CA/ATP2B4/GNAI2/MAPK9/PIK3R2	-1.11824497062609
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/1363	52/9376	0.661436875670184	HSD17B2/IGF1/CGA/HSD17B1/ACOT2	-1.00966241063729
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/1363	52/9376	0.661436875670184	CD36/PLTP/ANGPTL4/VDAC3/LIPG	-1.00966241063729
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/1363	94/9376	0.731802500741481	CCL2/S100A9/MMP1/SRSF1/IKBKG/IL17RA/ANAPC5/TRADD/IKBKB/MAPK9	-1.07778928968635
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/1363	78/9376	0.70553266738153	PLCH1/PLCB2/PIK3CG/INPP4B/MTMR1/MTMR6/OCRL/MTMR2	-1.07702466087461
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1363	16/9376	0.42993396918562	GOT2	-0.941202830722226
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1363	16/9376	0.42993396918562	B3GALNT1	-0.941202830722226
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1363	27/9376	0.509551370886661	HMGCLL1/ECHS1	-1.05251627948444
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/1363	37/9376	0.557752176240804	GSTZ1/GOT2/LRTOMT	-1.11160981710182
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/1363	82/9376	0.671116439704382	IMPDH2/GSTA4/NME1/MGST2/MGST1/NME7/ITPA/GSTM4	-1.23362667618023
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/1363	56/9376	0.614191384550886	CR1/CD14/RAB1B/CLK4/APAF1	-1.19424649039764
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	17/1363	156/9376	0.749628459092876	EGFR/TNFRSF1A/PPP2R1A/TP53/AKT2/IFIT1/AKT1/CCND1/IKBKG/BAX/TRADD/PPP2CB/APAF1/IKBKB/CDK4/CLDN5/PIK3R2	-1.30052227656166
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/1363	65/9376	0.634979400643377	ITPR2/CREB3L1/PLCB2/ORAI1/AGTR1/PDE8B	-1.21790070988065
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1363	28/9376	0.491353107640708	B3GALNT1/ST3GAL4	-1.1116601918838
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/1363	28/9376	0.491353107640708	SLC4A1/ATP6V1C2	-1.1116601918838
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	19/1363	173/9376	0.75549090538976	CCL2/ACTB/ACTG1/TNFRSF1A/PRKCA/SLC25A4/RAE1/AKT2/AKT1/IKBKG/IL33/BAX/TLR7/TRADD/KPNA5/APAF1/IKBKB/CDK4/PIK3R2	-1.33871877059207
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1363	17/9376	0.404643735704113	CH25H	-1.01326410828762
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1363	17/9376	0.404643735704113	INMT	-1.01326410828762
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1363	17/9376	0.404643735704113	CA8	-1.01326410828762
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/1363	49/9376	0.561546408732238	ST6GAL1/GXYLT2/POMT2/POFUT2	-1.2690732150037
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	10/1363	102/9376	0.674406226173522	ITPR2/RYR2/PRKCA/ATP1B1/CFTR/PLCB2/RAB27B/TRPC1/ATP2B4/RAB3D	-1.3635737319611
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/1363	86/9376	0.639901721578597	RYR2/PRKCA/ATP1B1/CREB3L1/PLCB2/VAMP2/KCNMB2/SLC2A1	-1.38356130864707
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1363	19/9376	0.362049658261575	HYAL2	-1.14797215731281
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1363	41/9376	0.503337329778287	GRIA4/GRIN2C/GABRA3	-1.31441431747609
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1363	79/9376	0.609526639858094	HPGDS/GSTA4/GSTK1/MGST2/MGST1/GSTM4/CBR1	-1.43737317180515
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	11/1363	115/9376	0.657985900666688	ITPR2/GNG2/GNGT1/GNG11/GNG10/GNG12/PRKCA/PLCB2/KCNJ5/TRPC1/GNAI2	-1.52194859058031
Human Diseases	Immune disease	hsa05310	Asthma	2/1363	32/9376	0.42993396918562	PRG2/FCER1G	-1.33220092843524
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/1363	72/9376	0.573245292247493	IKBKG/SIKE1/TRADD/IKBKB/PIN1/MAPK9	-1.49915215313165
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/1363	54/9376	0.509551370886661	MDH2/GOT2/GSS/ENOPH1	-1.49063684002647
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/1363	73/9376	0.565392617011226	HPGDS/GSTA4/GSTK1/MGST2/MGST1/GSTM4	-1.53738632618015
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/1363	44/9376	0.469018875475222	CD28/ICA1/PTPRN2	-1.45597544562054
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	17/1363	168/9376	0.69608356915767	PYGL/CYBB/TNFRSF1A/SLC25A4/VPS4A/IL33/SPATA2/BAX/RBCK1/CHMP4A/CHMP5/TRADD/PGAM5/VDAC3/PARP1/MAPK9/SHARPIN	-1.63931404806879
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/1363	65/9376	0.529149500536148	PLPP3/PLPP5/ALDH9A1/DGKQ/LIPG	-1.57100492014816
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	19/1363	187/9376	0.698930088943468	CCL2/ITPR2/ANTXR1/CYBB/CARD16/CYBA/PLCB2/GPSM3/IKBKG/PKN2/RBCK1/CASP5/CARD6/CARD9/BRCC3/IKBKB/VDAC3/MAPK9/SHARPIN	-1.71510228887746
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/1363	35/9376	0.393082486112567	GMPPB/ENOSF1	-1.48355277767872
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1363	66/9376	0.521132083861358	HSD17B2/HSD17B1/LRTOMT/HSD17B8/RDH5	-1.61008521709859
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/1363	23/9376	0.29908450030304	ATP1B1	-1.3880020560637
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/1363	95/9376	0.579279453218519	CCL2/CD28/ANGPT1/MMP1/ITGAL/TNFRSF11A/ATP6V1C2/CSF1	-1.69978555130171
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/1363	36/9376	0.382163528164996	ENPP1/PYGL	-1.53174809473517
Human Diseases	Substance dependence	hsa05034	Alcoholism	19/1363	191/9376	0.684292809593866	GNG2/GNGT1/GRIN2C/GNG11/GNG10/HDAC9/GNG12/CALM2/HDAC8/BDNF/CALML4/HDAC2/CREB3L1/SHC1/PPP1CC/SLC29A3/HDAC5/PPP1CA/GNAI2	-1.81801545709628
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/1363	38/9376	0.362049658261575	IKBKG/ORAI1	-1.62512859745172
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/1363	26/9376	0.264574750268074	SLC46A1	-1.54865757068433
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/1363	61/9376	0.451078262752126	SLC40A1/ATP1B1/SLC46A1/ATP2B4	-1.77386233286803
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	15/1363	163/9376	0.633031611070851	PRKCA/NFATC2/CREB3L1/TP53/AKT2/AKT1/IKBKG/MAP2K7/BAX/PCNA/APAF1/IKBKB/VDAC3/MAPK9/PIK3R2	-1.9492067947182
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/1363	133/9376	0.568935177268189	HCST/PRKCA/FCER1G/NFATC2/ITGAL/SHC1/RAC2/PPP3CB/PTPN6/SH3BP2/PIK3R2	-2.0648947600114
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1363	30/9376	0.229298116898997	PLAAT3	-1.74369352112279
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	30/1363	298/9376	0.692511091305697	CXCL14/BMP5/IL12RB2/EDA/CCL2/CCL4L2/TNFRSF25/TNFRSF12A/IL6ST/CSH1/CSF1R/BMP4/TNFRSF1A/BMPR1A/CCL13/EPOR/OSMR/LIFR/TNFSF12/IL33/IL17RA/PPBP/CXCL13/LTBR/TNFRSF11A/GDF15/BMP7/IL2RB/CSF1/CCL23	-2.2247360524081
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/1363	78/9376	0.440957917113456	CR1/CYBB/CYBA/NCF4/PTPN6	-2.04471614688626
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1363	31/9376	0.221901403450643	ALDH9A1	-1.78962410505842
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/1363	99/9376	0.486389944937267	KRT18/KRT19/C1S/ITGAL/CFI/C2/KRT10	-2.11876763927929
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/1363	109/9376	0.504876587667517	IL6ST/NFATC2/IKBKG/PPP3CB/IKBKB/MTOR/IL2RB/MAPK9	-2.14433742321226
NA	NA	hsa04382	Cornified envelope formation	20/1363	217/9376	0.634004009858979	S100A9/SLC27A4/KRT18/KRT19/SPTLC1/COL4A1/KRT1/PPP2R1A/TJP1/KRT8/ABHD5/ITGA6/ELOVL1/S100A1/PPP2CB/KRT7/KRT10/COL4A2/CLDN5/PPP2R5D	-2.24966659425997
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	20/1363	217/9376	0.634004009858979	EGFR/FGF7/PRKCA/PAQR7/FGF10/GSTA4/CREB3L1/AKT2/AKT1/CCND1/ADRB1/AIP/MGST2/MGST1/RPS6KB2/KPNA5/MTOR/GNAI2/GSTM4/PIK3R2	-2.24966659425997
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/1363	32/9376	0.21496698459281	GALK1	-1.8345624111013
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/1363	50/9376	0.275157740278797	CD28/LTBR	-2.11941887133115
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/1363	36/9376	0.191081764082498	DCXR	-2.00548045178217
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/1363	86/9376	0.399938575986623	SCN9A/GABRA3/PLCB2/PDE1C/PKD1L3	-2.30554217786349
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	15/1363	183/9376	0.563847828440157	FBL/NHP2/RAN/UTP4/IMP4/GAR1/UTP18/CSNK2A1/POP4/RPP25/MPHOSPH10/RRP7A/POP5/RPP30/PWP2	-2.45737224438806
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/1363	39/9376	0.176383166845383	CD28	-2.12564058278446
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/1363	54/9376	0.25477568544333	CD28/CGA	-2.26498505943409
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/1363	68/9376	0.303482801778085	DHRS4L2/RDH5/PNPLA4	-2.37735538488017
NA	NA	hsa04082	Neuroactive ligand signaling	16/1363	199/9376	0.553080884982506	GNG2/GNGT1/GRIA4/GRIN2C/GNG11/GNG10/GABRA3/GNG12/HRH1/TAC3/PRKCA/SLC1A1/PLCB2/ADRB1/GRIK2/GNAI2	-2.62809522526303
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	29/1363	323/9376	0.617614122916804	FSCN1/TPM1/EGFR/PRKCA/CCND2/PDGFRA/EFNA5/HDAC2/ZFPM2/ATM/CCNG1/UBE2I/MMP16/SHC1/TP53/CCND1/IRS1/STMN1/FGFR3/PIM1/CDKN1B/HDAC5/RECK/TNXB/CRKL/IGF2BP1/IKBKB/MTOR/PIK3R2	-2.88431600285394
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/1363	45/9376	0.152865411265998	CD28	-2.34925722612702
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/1363	90/9376	0.305730822531996	ATP1B1/ABCG2/CFTR/SLC2A1	-2.72942267197416
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/1363	66/9376	0.208452833544543	IL12RB2/MAF	-2.66139857859516
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/1363	82/9376	0.251668664889143	LGMN/NFYA/NFYB	-2.8069554367039
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/1363	143/9376	0.288627000292444	CD28/C1S/TRIM21/SNRPD1/C2/C9	-3.53533011846091
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	24/1363	370/9376	0.446201740992643	SPX/GRIA4/GRIN2C/GABRA3/CSH1/HRH1/TAC3/LYPD6/CGA/PTGFR/KISS1/ADRB1/VIPR2/S1PR1/S1PR3/AGTR1/APLN/APLNR/CHRNB1/GRIK2/S1PR2/PTH1R/LPAR6/THRA	-4.48252243182473
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/1363	449/9376	0.10724410812648	PRKG1/CALM2/CALML4/GRK2/GRK3/PDE1C/NCALD	-7.99538024752456