ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 84/2751 175/18639 0.48 3.25217011995638 1.15867336028155e-25 1.52017944868939e-22 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 36/2751 68/18639 0.529411764705882 3.58695233818718 1.90306147389372e-13 1.24840832687428e-10 GO:0009055 electron transfer activity 46/2751 116/18639 0.396551724137931 2.68677847553868 4.84489740173391e-11 2.1188351303583e-08 GO:0015078 proton transmembrane transporter activity 59/2751 185/18639 0.318918918918919 2.16078870582687 2.71789508836098e-09 8.91469588982401e-07 GO:0003954 NADH dehydrogenase activity 23/2751 44/18639 0.522727272727273 3.54166253593734 6.05134152752117e-09 1.58787201682155e-06 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 26/2751 58/18639 0.448275862068966 3.03722784191329 3.91284210787194e-08 8.30629624675128e-06 GO:0008137 NADH dehydrogenase (ubiquinone) activity 21/2751 41/18639 0.51219512195122 3.47030348166077 4.43171293652889e-08 8.30629624675128e-06 GO:0022853 active monoatomic ion transmembrane transporter activity 40/2751 118/18639 0.338983050847458 2.29673031070366 1.51839166789945e-07 2.4901623353551e-05 GO:0015399 primary active transmembrane transporter activity 49/2751 166/18639 0.295180722891566 1.99995401453141 8.0589005152255e-07 0.000117480860844176 GO:0016651 oxidoreductase activity, acting on NAD(P)H 30/2751 88/18639 0.340909090909091 2.30977991474175 4.59595921948913e-06 0.000602989849596974 GO:0005201 extracellular matrix structural constituent 47/2751 168/18639 0.279761904761905 1.89548605701823 6.80127712524577e-06 0.000776182272891231 GO:0004129 cytochrome-c oxidase activity 10/2751 15/18639 0.666666666666667 4.51690294438386 7.09922810571248e-06 0.000776182272891231 GO:0043021 ribonucleoprotein complex binding 48/2751 177/18639 0.271186440677966 1.83738424856293 1.36324764653863e-05 0.00137583147096822 GO:0016675 oxidoreductase activity, acting on a heme group of donors 10/2751 16/18639 0.625 4.23459651035987 1.64154138344424e-05 0.00153835878219917 GO:0019843 rRNA binding 23/2751 65/18639 0.353846153846154 2.3974331012499 2.93671381055249e-05 0.00256864567962991 GO:0055105 ubiquitin-protein transferase inhibitor activity 9/2751 15/18639 0.6 4.06521264994547 7.03759031647443e-05 0.00577082405950903 GO:0055106 ubiquitin-protein transferase regulator activity 15/2751 36/18639 0.416666666666667 2.82306434023991 8.42483072693941e-05 0.00650198700808501 GO:0030020 extracellular matrix structural constituent conferring tensile strength 17/2751 44/18639 0.386363636363636 2.61775057004065 9.01229404413366e-05 0.00656896099216853 GO:0031720 haptoglobin binding 7/2751 10/18639 0.7 4.74274809160305 0.000120374147692431 0.00831215167223521 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 9/2751 17/18639 0.529411764705882 3.58695233818718 0.000258079229268146 0.0161238070857051 GO:0019198 transmembrane receptor protein phosphatase activity 9/2751 17/18639 0.529411764705882 3.58695233818718 0.000258079229268146 0.0161238070857051 GO:0048407 platelet-derived growth factor binding 7/2751 11/18639 0.636363636363636 4.31158917418459 0.000288673156598592 0.0164669209329284 GO:1990948 ubiquitin ligase inhibitor activity 7/2751 11/18639 0.636363636363636 4.31158917418459 0.000288673156598592 0.0164669209329284 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 9/2751 18/18639 0.5 3.3876772082879 0.000448673189737879 0.0245274677056707 GO:0005007 fibroblast growth factor receptor activity 17/2751 50/18639 0.34 2.30362050163577 0.000536820676089908 0.0281723490811984 GO:0043022 ribosome binding 30/2751 112/18639 0.267857142857143 1.81482707586852 0.00065727144171343 0.0331669281356931 GO:0005021 vascular endothelial growth factor receptor activity 17/2751 51/18639 0.333333333333333 2.25845147219193 0.000695787918939401 0.0338101388758702 GO:0004721 phosphoprotein phosphatase activity 42/2751 175/18639 0.24 1.62608505997819 0.000797206028040969 0.0373547967424911 GO:0038064 collagen receptor activity 17/2751 53/18639 0.320754716981132 2.17322688833563 0.00113675472739084 0.0395197888764952 GO:0019838 growth factor binding 34/2751 136/18639 0.25 1.69383860414395 0.00114143094569428 0.0395197888764952 GO:0140104 molecular carrier activity 55/2751 249/18639 0.220883534136546 1.49656422856092 0.00119164693981246 0.0395197888764952 GO:0000993 RNA polymerase II complex binding 13/2751 36/18639 0.361111111111111 2.44665576154126 0.00126009949059335 0.0395197888764952 GO:0005004 GPI-linked ephrin receptor activity 16/2751 49/18639 0.326530612244898 2.21236062582067 0.00127152949239114 0.0395197888764952 GO:0005008 hepatocyte growth factor receptor activity 16/2751 49/18639 0.326530612244898 2.21236062582067 0.00127152949239114 0.0395197888764952 GO:0005009 insulin receptor activity 16/2751 49/18639 0.326530612244898 2.21236062582067 0.00127152949239114 0.0395197888764952 GO:0005011 macrophage colony-stimulating factor receptor activity 16/2751 49/18639 0.326530612244898 2.21236062582067 0.00127152949239114 0.0395197888764952 GO:0005018 platelet-derived growth factor alpha-receptor activity 16/2751 49/18639 0.326530612244898 2.21236062582067 0.00127152949239114 0.0395197888764952 GO:0005020 stem cell factor receptor activity 16/2751 49/18639 0.326530612244898 2.21236062582067 0.00127152949239114 0.0395197888764952 GO:0008288 boss receptor activity 16/2751 49/18639 0.326530612244898 2.21236062582067 0.00127152949239114 0.0395197888764952 GO:0036332 placental growth factor receptor activity 16/2751 49/18639 0.326530612244898 2.21236062582067 0.00127152949239114 0.0395197888764952 GO:0038062 protein tyrosine kinase collagen receptor activity 16/2751 49/18639 0.326530612244898 2.21236062582067 0.00127152949239114 0.0395197888764952 GO:0060175 brain-derived neurotrophic factor receptor activity 16/2751 49/18639 0.326530612244898 2.21236062582067 0.00127152949239114 0.0395197888764952 GO:0048027 mRNA 5'-UTR binding 10/2751 24/18639 0.416666666666667 2.82306434023991 0.00129523698299489 0.0395197888764952 GO:0032977 membrane insertase activity 8/2751 17/18639 0.470588235294118 3.18840207838861 0.00155200585408308 0.0442055116840561 GO:0048038 quinone binding 8/2751 17/18639 0.470588235294118 3.18840207838861 0.00155200585408308 0.0442055116840561 GO:0005006 epidermal growth factor receptor activity 16/2751 50/18639 0.32 2.16811341330425 0.00161727481770937 0.0442055116840561 GO:0005017 platelet-derived growth factor receptor activity 16/2751 50/18639 0.32 2.16811341330425 0.00161727481770937 0.0442055116840561 GO:0005019 platelet-derived growth factor beta-receptor activity 16/2751 50/18639 0.32 2.16811341330425 0.00161727481770937 0.0442055116840561 GO:0140297 DNA-binding transcription factor binding 96/2751 488/18639 0.19672131147541 1.3328566065395 0.00167752083809125 0.0443349641547588 GO:0004725 protein tyrosine phosphatase activity 26/2751 98/18639 0.26530612244898 1.79754300847929 0.00168959467053197 0.0443349641547588 GO:0001098 basal transcription machinery binding 18/2751 60/18639 0.3 2.03260632497274 0.00194270299777053 0.0461128633537901 GO:0001099 basal RNA polymerase II transcription machinery binding 18/2751 60/18639 0.3 2.03260632497274 0.00194270299777053 0.0461128633537901 GO:0004714 transmembrane receptor protein tyrosine kinase activity 18/2751 60/18639 0.3 2.03260632497274 0.00194270299777053 0.0461128633537901 GO:0005344 oxygen carrier activity 7/2751 14/18639 0.5 3.3876772082879 0.00199541159050889 0.0461128633537901 GO:0016859 cis-trans isomerase activity 14/2751 42/18639 0.333333333333333 2.25845147219193 0.00201528783402268 0.0461128633537901 GO:0043175 RNA polymerase core enzyme binding 14/2751 42/18639 0.333333333333333 2.25845147219193 0.00201528783402268 0.0461128633537901 GO:0005010 insulin-like growth factor receptor activity 16/2751 51/18639 0.313725490196078 2.1256013855924 0.0020385259714328 0.0461128633537901 GO:0005030 neurotrophin receptor activity 16/2751 51/18639 0.313725490196078 2.1256013855924 0.0020385259714328 0.0461128633537901 GO:0042578 phosphoric ester hydrolase activity 74/2751 363/18639 0.203856749311295 1.38120172679506 0.00209024381166056 0.0464813539135365 GO:0003713 transcription coactivator activity 55/2751 256/18639 0.21484375 1.4556425504362 0.00229293638401098 0.0501388755970401 GO:0070990 snRNP binding 6/2751 11/18639 0.545454545454545 3.69564786358679 0.00243117778553266 0.0515208007266731 GO:0070064 proline-rich region binding 8/2751 18/18639 0.444444444444444 3.01126862958924 0.00243467198555925 0.0515208007266731 GO:0005003 ephrin receptor activity 16/2751 53/18639 0.30188679245283 2.04539001255118 0.00315753849989441 0.0647295392478354 GO:0005005 transmembrane-ephrin receptor activity 16/2751 53/18639 0.30188679245283 2.04539001255118 0.00315753849989441 0.0647295392478354 GO:0008170 N-methyltransferase activity 25/2751 98/18639 0.255102040816327 1.7284067389224 0.00363406009378151 0.0733521052775591 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 38/2751 167/18639 0.227544910179641 1.54169741215497 0.00373168700020351 0.0741814143070759 GO:0005484 SNAP receptor activity 12/2751 36/18639 0.333333333333333 2.25845147219193 0.00413441097598825 0.0804449245968956 GO:0019902 phosphatase binding 42/2751 190/18639 0.221052631578947 1.49770992366412 0.00416940157971715 0.0804449245968956 GO:0140789 histone phosphatase activity 32/2751 136/18639 0.235294117647059 1.5942010391943 0.00434209075277837 0.0825626531542785 GO:0042826 histone deacetylase binding 30/2751 127/18639 0.236220472440945 1.60047742123838 0.00529783606495961 0.0992965845318144 GO:0016791 phosphatase activity 56/2751 273/18639 0.205128205128205 1.38981629057965 0.00591698112586749 0.109339144185044 GO:0003785 actin monomer binding 10/2751 29/18639 0.344827586206897 2.33632910916407 0.00657000985771723 0.119720179629514 GO:0004601 peroxidase activity 16/2751 57/18639 0.280701754385965 1.90185387131952 0.00691533840838867 0.122833385878793 GO:0070700 BMP receptor binding 6/2751 13/18639 0.461538461538462 3.12708665380421 0.00692810255718802 0.122833385878793 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 12/2751 39/18639 0.307692307692308 2.08472443586947 0.00845228172740516 0.145278597709847 GO:0016741 transferase activity, transferring one-carbon groups 45/2751 215/18639 0.209302325581395 1.41809743602749 0.00879025827940206 0.145278597709847 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 22/2751 89/18639 0.247191011235955 1.67480670971536 0.00903136844606664 0.145278597709847 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 22/2751 89/18639 0.247191011235955 1.67480670971536 0.00903136844606664 0.145278597709847 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 68/2751 349/18639 0.194842406876791 1.32012636196892 0.00908570481571711 0.145278597709847 GO:0008239 dipeptidyl-peptidase activity 5/2751 10/18639 0.5 3.3876772082879 0.00919064299536378 0.145278597709847 GO:0015924 mannosyl-oligosaccharide mannosidase activity 5/2751 10/18639 0.5 3.3876772082879 0.00919064299536378 0.145278597709847 GO:0033204 ribonuclease P RNA binding 5/2751 10/18639 0.5 3.3876772082879 0.00919064299536378 0.145278597709847 GO:0140999 histone H3K4 trimethyltransferase activity 5/2751 10/18639 0.5 3.3876772082879 0.00919064299536378 0.145278597709847 GO:0016279 protein-lysine N-methyltransferase activity 18/2751 69/18639 0.260869565217391 1.76748376084586 0.00979048963909447 0.149938195787563 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 16/2751 59/18639 0.271186440677966 1.83738424856293 0.0098282658824165 0.149938195787563 GO:0070063 RNA polymerase binding 16/2751 59/18639 0.271186440677966 1.83738424856293 0.0098282658824165 0.149938195787563 GO:0140793 histone H2AXY142 phosphatase activity 22/2751 90/18639 0.244444444444444 1.65619774627408 0.0103282643207947 0.155754974584858 GO:0031690 adrenergic receptor binding 7/2751 18/18639 0.388888888888889 2.63486005089059 0.010792394985838 0.159818684619758 GO:0005178 integrin binding 35/2751 161/18639 0.217391304347826 1.47290313403822 0.0108413589414317 0.159818684619758 GO:0051539 4 iron, 4 sulfur cluster binding 13/2751 45/18639 0.288888888888889 1.95732460923301 0.011040711782499 0.160949042873764 GO:0016278 lysine N-methyltransferase activity 18/2751 70/18639 0.257142857142857 1.74223399283377 0.0114059198677035 0.164445789740956 GO:0038024 cargo receptor activity 17/2751 65/18639 0.261538461538462 1.77201577048905 0.0115494545824676 0.164705265349972 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 11/2751 36/18639 0.305555555555556 2.0702471828426 0.0121223953387861 0.167416659836709 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 11/2751 36/18639 0.305555555555556 2.0702471828426 0.0121223953387861 0.167416659836709 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 11/2751 36/18639 0.305555555555556 2.0702471828426 0.0121223953387861 0.167416659836709 GO:0008320 protein transmembrane transporter activity 9/2751 27/18639 0.333333333333333 2.25845147219193 0.0124168019159152 0.167946846532791 GO:0015252 proton channel activity 9/2751 27/18639 0.333333333333333 2.25845147219193 0.0124168019159152 0.167946846532791 GO:0140318 protein transporter activity 12/2751 41/18639 0.292682926829268 1.98303056094901 0.0128814309046551 0.171194577833194 GO:0051536 iron-sulfur cluster binding 19/2751 76/18639 0.25 1.69383860414395 0.0129178835407669 0.171194577833194 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 16/2751 61/18639 0.262295081967213 1.77714214205267 0.0136363164588042 0.178908471939512 GO:0022884 macromolecule transmembrane transporter activity 10/2751 32/18639 0.3125 2.11729825517993 0.0139517028650926 0.181234001574272 GO:0030695 GTPase regulator activity 90/2751 489/18639 0.184049079754601 1.24699774538205 0.014369249741065 0.184827996669385 GO:0008046 axon guidance receptor activity 5/2751 11/18639 0.454545454545455 3.079706552989 0.014823530670223 0.185424019293492 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 5/2751 11/18639 0.454545454545455 3.079706552989 0.014823530670223 0.185424019293492 GO:0051540 metal cluster binding 19/2751 77/18639 0.246753246753247 1.67184070019403 0.0148395747147992 0.185424019293492 GO:0060589 nucleoside-triphosphatase regulator activity 90/2751 490/18639 0.183673469387755 1.24445285202412 0.0151169114912523 0.185988452490933 GO:0004559 alpha-mannosidase activity 6/2751 15/18639 0.4 2.71014176663032 0.0155342689061889 0.185988452490933 GO:0141050 histone H3K deacetylase activity 6/2751 15/18639 0.4 2.71014176663032 0.0155342689061889 0.185988452490933 GO:0141051 histone H4K deacetylase activity 6/2751 15/18639 0.4 2.71014176663032 0.0155342689061889 0.185988452490933 GO:0042054 histone methyltransferase activity 17/2751 67/18639 0.253731343283582 1.71911977734013 0.0156354010988124 0.185988452490933 GO:0045296 cadherin binding 64/2751 334/18639 0.191616766467066 1.29827150497261 0.0157353035262908 0.185988452490933 GO:0051537 2 iron, 2 sulfur cluster binding 9/2751 28/18639 0.321428571428571 2.17779249104222 0.0159544286546208 0.186894735668415 GO:0019199 transmembrane receptor protein kinase activity 19/2751 78/18639 0.243589743589744 1.65040684506333 0.01697841549297 0.197129921475899 GO:0019903 protein phosphatase binding 31/2751 144/18639 0.215277777777778 1.45858324245729 0.0180147226584003 0.206099821131526 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 8/2751 24/18639 0.333333333333333 2.25845147219193 0.0180651520046688 0.206099821131526 GO:0008408 3'-5' exonuclease activity 15/2751 58/18639 0.258620689655172 1.75224683187305 0.0188526467416231 0.213229935560427 GO:0008276 protein methyltransferase activity 22/2751 95/18639 0.231578947368421 1.5690294438386 0.0192241949783994 0.215202426655335 GO:0003712 transcription coregulator activity 90/2751 495/18639 0.181818181818182 1.2318826211956 0.0193550962997939 0.215202426655335 GO:0140939 histone H4 methyltransferase activity 7/2751 20/18639 0.35 2.37137404580153 0.0201294455568836 0.221931366139759 GO:0004713 protein tyrosine kinase activity 30/2751 140/18639 0.214285714285714 1.45186166069481 0.0209461449947952 0.229011185276428 GO:0015923 mannosidase activity 6/2751 16/18639 0.375 2.54075790621592 0.0218094513772634 0.231101702335692 GO:0051287 NAD binding 14/2751 54/18639 0.259259259259259 1.75657336726039 0.0223432427108668 0.231101702335692 GO:0004526 ribonuclease P activity 5/2751 12/18639 0.416666666666667 2.82306434023991 0.0223703629547507 0.231101702335692 GO:0005049 nuclear export signal receptor activity 5/2751 12/18639 0.416666666666667 2.82306434023991 0.0223703629547507 0.231101702335692 GO:0034452 dynactin binding 5/2751 12/18639 0.416666666666667 2.82306434023991 0.0223703629547507 0.231101702335692 GO:0043047 single-stranded telomeric DNA binding 5/2751 12/18639 0.416666666666667 2.82306434023991 0.0223703629547507 0.231101702335692 GO:0141221 histone deacetylase activity, hydrolytic mechanism 5/2751 12/18639 0.416666666666667 2.82306434023991 0.0223703629547507 0.231101702335692 GO:0008168 methyltransferase activity 41/2751 204/18639 0.200980392156863 1.36171338764513 0.0227900940739013 0.233598464257488 GO:0005537 D-mannose binding 8/2751 25/18639 0.32 2.16811341330425 0.0232126132415405 0.236084872658149 GO:0016209 antioxidant activity 20/2751 86/18639 0.232558139534884 1.57566381780832 0.023736322686118 0.239554272032206 GO:0032182 ubiquitin-like protein binding 26/2751 120/18639 0.216666666666667 1.46799345692475 0.0263926186783177 0.263751765418314 GO:0005096 GTPase activator activity 52/2751 271/18639 0.191881918819188 1.30006800613262 0.026555765973953 0.263751765418314 GO:0004177 aminopeptidase activity 11/2751 40/18639 0.275 1.86322246455834 0.0267370310980455 0.263751765418314 GO:0035401 histone H3Y41 kinase activity 25/2751 115/18639 0.217391304347826 1.47290313403822 0.0279563206952615 0.271694020386541 GO:0140801 histone H2AXY142 kinase activity 25/2751 115/18639 0.217391304347826 1.47290313403822 0.0279563206952615 0.271694020386541 GO:0008201 heparin binding 35/2751 172/18639 0.203488372093023 1.37870584058228 0.0281977129364552 0.272024995386979 GO:0070006 metalloaminopeptidase activity 8/2751 26/18639 0.307692307692308 2.08472443586947 0.0293083354943842 0.275348837009339 GO:0004549 tRNA-specific ribonuclease activity 6/2751 17/18639 0.352941176470588 2.39130155879146 0.0295916051968879 0.275348837009339 GO:0004659 prenyltransferase activity 6/2751 17/18639 0.352941176470588 2.39130155879146 0.0295916051968879 0.275348837009339 GO:0030169 low-density lipoprotein particle binding 6/2751 17/18639 0.352941176470588 2.39130155879146 0.0295916051968879 0.275348837009339 GO:0070402 NADPH binding 6/2751 17/18639 0.352941176470588 2.39130155879146 0.0295916051968879 0.275348837009339 GO:0044390 ubiquitin-like protein conjugating enzyme binding 10/2751 36/18639 0.277777777777778 1.88204289349328 0.0316807731826064 0.288429078654706 GO:0140101 catalytic activity, acting on a tRNA 29/2751 139/18639 0.20863309352518 1.4135631516597 0.0318096040509318 0.288429078654706 GO:0039706 co-receptor binding 5/2751 13/18639 0.384615384615385 2.60590554483684 0.0320217757032274 0.288429078654706 GO:0016500 protein-hormone receptor activity 16/2751 67/18639 0.238805970149254 1.61799508455541 0.0320965285698073 0.288429078654706 GO:0050840 extracellular matrix binding 16/2751 67/18639 0.238805970149254 1.61799508455541 0.0320965285698073 0.288429078654706 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 27/2751 128/18639 0.2109375 1.42917632224646 0.0328979552538214 0.293219537011334 GO:0016853 isomerase activity 36/2751 180/18639 0.2 1.35507088331516 0.0333646316067981 0.293219537011334 GO:0008649 rRNA methyltransferase activity 7/2751 22/18639 0.318181818181818 2.1557945870923 0.0339705561171668 0.293219537011334 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 7/2751 22/18639 0.318181818181818 2.1557945870923 0.0339705561171668 0.293219537011334 GO:0030021 extracellular matrix structural constituent conferring compression resistance 7/2751 22/18639 0.318181818181818 2.1557945870923 0.0339705561171668 0.293219537011334 GO:0140517 protein-RNA adaptor activity 7/2751 22/18639 0.318181818181818 2.1557945870923 0.0339705561171668 0.293219537011334 GO:0004527 exonuclease activity 19/2751 84/18639 0.226190476190476 1.53252064184452 0.0352217410979013 0.302032185100957 GO:0005044 scavenger receptor activity 8/2751 27/18639 0.296296296296296 2.00751241972616 0.0364205601590027 0.310284252783191 GO:0031369 translation initiation factor binding 9/2751 32/18639 0.28125 1.90556842966194 0.0375757257875339 0.318060336988674 GO:0019213 deacetylase activity 10/2751 37/18639 0.27027027027027 1.83117686934481 0.0378572956741734 0.318389563618689 GO:0030228 lipoprotein particle receptor activity 6/2751 18/18639 0.333333333333333 2.25845147219193 0.0389912103024129 0.320921651927554 GO:0031491 nucleosome binding 17/2751 74/18639 0.22972972972973 1.55650033894309 0.0391116680630014 0.320921651927554 GO:0048029 monosaccharide binding 17/2751 74/18639 0.22972972972973 1.55650033894309 0.0391116680630014 0.320921651927554 GO:0140098 catalytic activity, acting on RNA 70/2751 387/18639 0.180878552971576 1.22551630273981 0.0391367868204334 0.320921651927554 GO:0016860 intramolecular oxidoreductase activity 13/2751 53/18639 0.245283018867925 1.66187938519784 0.0413104295158445 0.334281523487639 GO:0051020 GTPase binding 58/2751 315/18639 0.184126984126984 1.24752557511554 0.0418488242125644 0.334281523487639 GO:0032266 phosphatidylinositol-3-phosphate binding 12/2751 48/18639 0.25 1.69383860414395 0.0427467154844284 0.334281523487639 GO:0017134 fibroblast growth factor binding 7/2751 23/18639 0.304347826086957 2.0620643876535 0.0428000257551888 0.334281523487639 GO:0140102 catalytic activity, acting on a rRNA 7/2751 23/18639 0.304347826086957 2.0620643876535 0.0428000257551888 0.334281523487639 GO:0016530 metallochaperone activity 5/2751 14/18639 0.357142857142857 2.41976943449135 0.0439074173260217 0.334281523487639 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 5/2751 14/18639 0.357142857142857 2.41976943449135 0.0439074173260217 0.334281523487639 GO:0098847 sequence-specific single stranded DNA binding 5/2751 14/18639 0.357142857142857 2.41976943449135 0.0439074173260217 0.334281523487639 GO:0046875 ephrin receptor binding 8/2751 28/18639 0.285714285714286 1.93581554759308 0.0446070127607555 0.334281523487639 GO:0016874 ligase activity 33/2751 167/18639 0.197604790419162 1.338842489503 0.0466111672394861 0.334281523487639 GO:0017069 snRNA binding 13/2751 54/18639 0.240740740740741 1.6311038410275 0.0473244155759594 0.334281523487639 GO:0004090 carbonyl reductase (NADPH) activity 4/2751 10/18639 0.4 2.71014176663032 0.0473905208602903 0.334281523487639 GO:0005522 profilin binding 4/2751 10/18639 0.4 2.71014176663032 0.0473905208602903 0.334281523487639 GO:0005528 FK506 binding 4/2751 10/18639 0.4 2.71014176663032 0.0473905208602903 0.334281523487639 GO:0008641 ubiquitin-like modifier activating enzyme activity 4/2751 10/18639 0.4 2.71014176663032 0.0473905208602903 0.334281523487639 GO:0030957 Tat protein binding 4/2751 10/18639 0.4 2.71014176663032 0.0473905208602903 0.334281523487639 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 4/2751 10/18639 0.4 2.71014176663032 0.0473905208602903 0.334281523487639 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 4/2751 10/18639 0.4 2.71014176663032 0.0473905208602903 0.334281523487639 GO:0047429 nucleoside triphosphate diphosphatase activity 4/2751 10/18639 0.4 2.71014176663032 0.0473905208602903 0.334281523487639 GO:0070513 death domain binding 4/2751 10/18639 0.4 2.71014176663032 0.0473905208602903 0.334281523487639 GO:0098505 G-rich strand telomeric DNA binding 4/2751 10/18639 0.4 2.71014176663032 0.0473905208602903 0.334281523487639 GO:0140940 histone H2A methyltransferase activity 4/2751 10/18639 0.4 2.71014176663032 0.0473905208602903 0.334281523487639 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 4/2751 10/18639 0.4 2.71014176663032 0.0473905208602903 0.334281523487639 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 4/2751 10/18639 0.4 2.71014176663032 0.0473905208602903 0.334281523487639 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 4/2751 10/18639 0.4 2.71014176663032 0.0473905208602903 0.334281523487639 GO:1990259 histone H2AQ104 methyltransferase activity 4/2751 10/18639 0.4 2.71014176663032 0.0473905208602903 0.334281523487639 GO:1901681 sulfur compound binding 51/2751 275/18639 0.185454545454545 1.25652027361951 0.0479205630095687 0.336212720152696 GO:0003697 single-stranded DNA binding 25/2751 121/18639 0.206611570247934 1.399866614995 0.0484120062873252 0.337854001324312 GO:0160215 deacylase activity 15/2751 65/18639 0.230769230769231 1.56354332690211 0.0487859072905787 0.33866195960444 GO:0042800 histone H3K4 methyltransferase activity 6/2751 19/18639 0.315789473684211 2.13958560523446 0.0500874761056856 0.345867203424524 GO:0022804 active transmembrane transporter activity 80/2751 457/18639 0.175054704595186 1.18605766592136 0.0561978179994163 0.386028990655677 GO:0005041 low-density lipoprotein particle receptor activity 5/2751 15/18639 0.333333333333333 2.25845147219193 0.0580939915359383 0.386900085762188 GO:0005523 tropomyosin binding 5/2751 15/18639 0.333333333333333 2.25845147219193 0.0580939915359383 0.386900085762188 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 5/2751 15/18639 0.333333333333333 2.25845147219193 0.0580939915359383 0.386900085762188 GO:0031386 protein tag activity 5/2751 15/18639 0.333333333333333 2.25845147219193 0.0580939915359383 0.386900085762188 GO:0034483 heparan sulfate sulfotransferase activity 5/2751 15/18639 0.333333333333333 2.25845147219193 0.0580939915359383 0.386900085762188 GO:0141047 molecular tag activity 5/2751 15/18639 0.333333333333333 2.25845147219193 0.0580939915359383 0.386900085762188 GO:0004860 protein kinase inhibitor activity 18/2751 84/18639 0.214285714285714 1.45186166069481 0.0629228435253911 0.416943286390471 GO:0033612 receptor serine/threonine kinase binding 8/2751 30/18639 0.266666666666667 1.80676117775354 0.0643730208698357 0.419340621465692 GO:0000030 mannosyltransferase activity 7/2751 25/18639 0.28 1.89709923664122 0.064563113975663 0.419340621465692 GO:0003707 nuclear steroid receptor activity 7/2751 25/18639 0.28 1.89709923664122 0.064563113975663 0.419340621465692 GO:0017056 structural constituent of nuclear pore 7/2751 25/18639 0.28 1.89709923664122 0.064563113975663 0.419340621465692 GO:0019210 kinase inhibitor activity 19/2751 90/18639 0.211111111111111 1.43035259905489 0.0649470544241532 0.419756332041818 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 4/2751 11/18639 0.363636363636364 2.4637652423912 0.0660002295403289 0.420350976489862 GO:0050998 nitric-oxide synthase binding 4/2751 11/18639 0.363636363636364 2.4637652423912 0.0660002295403289 0.420350976489862 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 4/2751 11/18639 0.363636363636364 2.4637652423912 0.0660002295403289 0.420350976489862 GO:0016877 ligase activity, forming carbon-sulfur bonds 10/2751 41/18639 0.24390243902439 1.65252546745751 0.0706913358578178 0.44805329780414 GO:0017070 U6 snRNA binding 5/2751 16/18639 0.3125 2.11729825517993 0.0745869643353359 0.46822056080364 GO:0097027 ubiquitin-protein transferase activator activity 5/2751 16/18639 0.3125 2.11729825517993 0.0745869643353359 0.46822056080364 GO:0017147 Wnt-protein binding 8/2751 31/18639 0.258064516129032 1.74847855911633 0.0760048648800055 0.474849441536035 GO:0035091 phosphatidylinositol binding 51/2751 284/18639 0.179577464788732 1.21670096917382 0.0765729410793283 0.476131273441131 GO:0140938 histone H3 methyltransferase activity 11/2751 47/18639 0.234042553191489 1.58572124643263 0.0769479620839923 0.476206255916028 GO:0004112 cyclic-nucleotide phosphodiesterase activity 7/2751 26/18639 0.269230769230769 1.82413388138579 0.0775517165740288 0.477689446690731 GO:0030971 receptor tyrosine kinase binding 17/2751 81/18639 0.209876543209877 1.4219879639727 0.0812339087541355 0.498032188249653 GO:0008081 phosphoric diester hydrolase activity 18/2751 87/18639 0.206896551724138 1.40179746549844 0.0832213229699904 0.506300738192294 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 24/2751 122/18639 0.19672131147541 1.3328566065395 0.0833543898243411 0.506300738192294 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 11/2751 48/18639 0.229166666666667 1.55268538713195 0.0871159002622408 0.514345953736833 GO:0000340 RNA 7-methylguanosine cap binding 4/2751 12/18639 0.333333333333333 2.25845147219193 0.0878151628331179 0.514345953736833 GO:0005527 macrolide binding 4/2751 12/18639 0.333333333333333 2.25845147219193 0.0878151628331179 0.514345953736833 GO:0016208 AMP binding 4/2751 12/18639 0.333333333333333 2.25845147219193 0.0878151628331179 0.514345953736833 GO:0036009 protein-glutamine N-methyltransferase activity 4/2751 12/18639 0.333333333333333 2.25845147219193 0.0878151628331179 0.514345953736833 GO:0045295 gamma-catenin binding 4/2751 12/18639 0.333333333333333 2.25845147219193 0.0878151628331179 0.514345953736833 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 4/2751 12/18639 0.333333333333333 2.25845147219193 0.0878151628331179 0.514345953736833 GO:1990459 transferrin receptor binding 4/2751 12/18639 0.333333333333333 2.25845147219193 0.0878151628331179 0.514345953736833 GO:0051059 NF-kappaB binding 8/2751 32/18639 0.25 1.69383860414395 0.0888145779108294 0.515596133712426 GO:0140142 nucleocytoplasmic carrier activity 8/2751 32/18639 0.25 1.69383860414395 0.0888145779108294 0.515596133712426 GO:0004364 glutathione transferase activity 7/2751 27/18639 0.259259259259259 1.75657336726039 0.0919476213192879 0.526220424990259 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 7/2751 27/18639 0.259259259259259 1.75657336726039 0.0919476213192879 0.526220424990259 GO:0045125 bioactive lipid receptor activity 5/2751 17/18639 0.294117647058824 1.99275129899288 0.0933350306430226 0.526220424990259 GO:0043130 ubiquitin binding 20/2751 100/18639 0.2 1.35507088331516 0.0935591885928819 0.526220424990259 GO:0004407 histone deacetylase activity 6/2751 22/18639 0.272727272727273 1.8478239317934 0.0938533379936895 0.526220424990259 GO:0008093 cytoskeletal anchor activity 6/2751 22/18639 0.272727272727273 1.8478239317934 0.0938533379936895 0.526220424990259 GO:0033558 protein lysine deacetylase activity 6/2751 22/18639 0.272727272727273 1.8478239317934 0.0938533379936895 0.526220424990259 GO:0061133 endopeptidase activator activity 6/2751 22/18639 0.272727272727273 1.8478239317934 0.0938533379936895 0.526220424990259 GO:0042162 telomeric DNA binding 9/2751 38/18639 0.236842105263158 1.60468920392585 0.0975613245330467 0.544126558427806 GO:0031267 small GTPase binding 50/2751 283/18639 0.176678445229682 1.19705908420067 0.0978764236196358 0.544126558427806 GO:0004518 nuclease activity 38/2751 209/18639 0.181818181818182 1.2318826211956 0.0983096023782482 0.544228684895619 GO:0008235 metalloexopeptidase activity 14/2751 66/18639 0.212121212121212 1.43719639139486 0.0993914004353543 0.547905535173046 GO:0045499 chemorepellent activity 7/2751 28/18639 0.25 1.69383860414395 0.107727824172132 0.591376172861243 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 14/2751 67/18639 0.208955223880597 1.41574569898599 0.109423050144196 0.593362399996038 GO:0005539 glycosaminoglycan binding 43/2751 242/18639 0.177685950413223 1.2038852888957 0.109764438093424 0.593362399996038 GO:0004602 glutathione peroxidase activity 6/2751 23/18639 0.260869565217391 1.76748376084586 0.111872154077866 0.593362399996038 GO:0005158 insulin receptor binding 6/2751 23/18639 0.260869565217391 1.76748376084586 0.111872154077866 0.593362399996038 GO:0070577 lysine-acetylated histone binding 6/2751 23/18639 0.260869565217391 1.76748376084586 0.111872154077866 0.593362399996038 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 4/2751 13/18639 0.307692307692308 2.08472443586947 0.112612223779736 0.593362399996038 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 4/2751 13/18639 0.307692307692308 2.08472443586947 0.112612223779736 0.593362399996038 GO:0005338 nucleotide-sugar transmembrane transporter activity 4/2751 13/18639 0.307692307692308 2.08472443586947 0.112612223779736 0.593362399996038 GO:0035325 Toll-like receptor binding 4/2751 13/18639 0.307692307692308 2.08472443586947 0.112612223779736 0.593362399996038 GO:0035673 oligopeptide transmembrane transporter activity 4/2751 13/18639 0.307692307692308 2.08472443586947 0.112612223779736 0.593362399996038 GO:0035615 clathrin adaptor activity 5/2751 18/18639 0.277777777777778 1.88204289349328 0.114236500004796 0.597124653411521 GO:1990381 ubiquitin-specific protease binding 5/2751 18/18639 0.277777777777778 1.88204289349328 0.114236500004796 0.597124653411521 GO:0019207 kinase regulator activity 50/2751 287/18639 0.174216027874564 1.18037533389822 0.116924955618649 0.608489114817786 GO:0004722 protein serine/threonine phosphatase activity 20/2751 103/18639 0.194174757281553 1.3156027993351 0.117710898405791 0.608489114817786 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 8/2751 34/18639 0.235294117647059 1.5942010391943 0.117921089450501 0.608489114817786 GO:0017124 SH3 domain binding 22/2751 115/18639 0.191304347826087 1.29615475795363 0.118265795944006 0.608489114817786 GO:0140597 protein carrier chaperone 34/2751 188/18639 0.180851063829787 1.22533005406158 0.118847691825548 0.609094420605936 GO:0016504 peptidase activator activity 12/2751 57/18639 0.210526315789474 1.42639040348964 0.126087344608751 0.643683253411212 GO:0002039 p53 binding 14/2751 69/18639 0.202898550724638 1.374709591769 0.131222448998317 0.653985323617737 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 6/2751 24/18639 0.25 1.69383860414395 0.131501214180452 0.653985323617737 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 6/2751 24/18639 0.25 1.69383860414395 0.131501214180452 0.653985323617737 GO:0140033 acetylation-dependent protein binding 6/2751 24/18639 0.25 1.69383860414395 0.131501214180452 0.653985323617737 GO:0033192 calmodulin-dependent protein phosphatase activity 16/2751 81/18639 0.197530864197531 1.33834161315077 0.134086929918576 0.653985323617737 GO:0140791 histone H2AXS140 phosphatase activity 16/2751 81/18639 0.197530864197531 1.33834161315077 0.134086929918576 0.653985323617737 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 16/2751 81/18639 0.197530864197531 1.33834161315077 0.134086929918576 0.653985323617737 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 16/2751 81/18639 0.197530864197531 1.33834161315077 0.134086929918576 0.653985323617737 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 16/2751 81/18639 0.197530864197531 1.33834161315077 0.134086929918576 0.653985323617737 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 16/2751 81/18639 0.197530864197531 1.33834161315077 0.134086929918576 0.653985323617737 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 16/2751 81/18639 0.197530864197531 1.33834161315077 0.134086929918576 0.653985323617737 GO:1990439 MAP kinase serine/threonine phosphatase activity 16/2751 81/18639 0.197530864197531 1.33834161315077 0.134086929918576 0.653985323617737 GO:0003779 actin binding 74/2751 443/18639 0.167042889390519 1.13177477838964 0.136182938488138 0.66153194035353 GO:0003756 protein disulfide isomerase activity 5/2751 19/18639 0.263157894736842 1.78298800436205 0.137146865683049 0.66153194035353 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 5/2751 19/18639 0.263157894736842 1.78298800436205 0.137146865683049 0.66153194035353 GO:0008174 mRNA methyltransferase activity 4/2751 14/18639 0.285714285714286 1.93581554759308 0.140094146361222 0.6683764364579 GO:0008191 metalloendopeptidase inhibitor activity 4/2751 14/18639 0.285714285714286 1.93581554759308 0.140094146361222 0.6683764364579 GO:0030983 mismatched DNA binding 4/2751 14/18639 0.285714285714286 1.93581554759308 0.140094146361222 0.6683764364579 GO:0003714 transcription corepressor activity 36/2751 204/18639 0.176470588235294 1.19565077939573 0.142819050886718 0.678530222081035 GO:0031624 ubiquitin conjugating enzyme binding 7/2751 30/18639 0.233333333333333 1.58091603053435 0.14325676182656 0.678530222081035 GO:0098631 cell adhesion mediator activity 15/2751 76/18639 0.197368421052632 1.33724100327154 0.144205911798452 0.679482358971846 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 16/2751 82/18639 0.195121951219512 1.32202037396601 0.14501147904887 0.679482358971846 GO:0033549 MAP kinase phosphatase activity 16/2751 82/18639 0.195121951219512 1.32202037396601 0.14501147904887 0.679482358971846 GO:0001784 phosphotyrosine residue binding 10/2751 47/18639 0.212765957446809 1.44156476948421 0.145916333703839 0.681289074090521 GO:0019887 protein kinase regulator activity 44/2751 255/18639 0.172549019607843 1.16908076207582 0.148850212598348 0.692522974925647 GO:0000287 magnesium ion binding 40/2751 230/18639 0.173913043478261 1.17832250723057 0.1496494868543 0.693781366617816 GO:0016922 nuclear receptor binding 25/2751 137/18639 0.182481751824818 1.23637854317076 0.150559340656418 0.695541742750776 GO:0004879 nuclear receptor activity 12/2751 59/18639 0.203389830508475 1.37803818642219 0.15218413384376 0.698131411199349 GO:0045309 protein phosphorylated amino acid binding 12/2751 59/18639 0.203389830508475 1.37803818642219 0.15218413384376 0.698131411199349 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 16/2751 83/18639 0.192771084337349 1.30609241765316 0.156411251544777 0.715022864204693 GO:0048487 beta-tubulin binding 9/2751 42/18639 0.214285714285714 1.45186166069481 0.157278809082176 0.716492352485466 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 24/2751 132/18639 0.181818181818182 1.2318826211956 0.160808238661219 0.722697108945038 GO:0000339 RNA cap binding 5/2751 20/18639 0.25 1.69383860414395 0.161886943559008 0.722697108945038 GO:0043024 ribosomal small subunit binding 5/2751 20/18639 0.25 1.69383860414395 0.161886943559008 0.722697108945038 GO:0050661 NADP binding 11/2751 54/18639 0.203703703703704 1.38016478856173 0.164262002371785 0.722697108945038 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 12/2751 60/18639 0.2 1.35507088331516 0.166205814729246 0.722697108945038 GO:0098531 ligand-modulated transcription factor activity 12/2751 60/18639 0.2 1.35507088331516 0.166205814729246 0.722697108945038 GO:0005518 collagen binding 14/2751 72/18639 0.194444444444444 1.31743002544529 0.168123421606922 0.722697108945038 GO:0017018 myosin phosphatase activity 16/2751 84/18639 0.19047619047619 1.29054369839539 0.168274808801184 0.722697108945038 GO:0015929 hexosaminidase activity 4/2751 15/18639 0.266666666666667 1.80676117775354 0.169912384479506 0.722697108945038 GO:0140776 protein-containing complex destabilizing activity 4/2751 15/18639 0.266666666666667 1.80676117775354 0.169912384479506 0.722697108945038 GO:0140658 ATP-dependent chromatin remodeler activity 28/2751 158/18639 0.177215189873418 1.20069571939318 0.172258277854951 0.722697108945038 GO:0004540 RNA nuclease activity 22/2751 121/18639 0.181818181818182 1.2318826211956 0.173376247906426 0.722697108945038 GO:0051082 unfolded protein binding 22/2751 121/18639 0.181818181818182 1.2318826211956 0.173376247906426 0.722697108945038 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 3/2751 10/18639 0.3 2.03260632497274 0.173547821806592 0.722697108945038 GO:0003680 minor groove of adenine-thymine-rich DNA binding 3/2751 10/18639 0.3 2.03260632497274 0.173547821806592 0.722697108945038 GO:0005031 tumor necrosis factor receptor activity 3/2751 10/18639 0.3 2.03260632497274 0.173547821806592 0.722697108945038 GO:0005345 purine nucleobase transmembrane transporter activity 3/2751 10/18639 0.3 2.03260632497274 0.173547821806592 0.722697108945038 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 3/2751 10/18639 0.3 2.03260632497274 0.173547821806592 0.722697108945038 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 3/2751 10/18639 0.3 2.03260632497274 0.173547821806592 0.722697108945038 GO:0043295 glutathione binding 3/2751 10/18639 0.3 2.03260632497274 0.173547821806592 0.722697108945038 GO:0097177 mitochondrial ribosome binding 3/2751 10/18639 0.3 2.03260632497274 0.173547821806592 0.722697108945038 GO:0099122 RNA polymerase II C-terminal domain binding 3/2751 10/18639 0.3 2.03260632497274 0.173547821806592 0.722697108945038 GO:1990757 ubiquitin ligase activator activity 3/2751 10/18639 0.3 2.03260632497274 0.173547821806592 0.722697108945038 GO:0008200 ion channel inhibitor activity 9/2751 43/18639 0.209302325581395 1.41809743602749 0.174482102784677 0.722697108945038 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 9/2751 43/18639 0.209302325581395 1.41809743602749 0.174482102784677 0.722697108945038 GO:0030247 polysaccharide binding 6/2751 26/18639 0.230769230769231 1.56354332690211 0.175165915125398 0.722697108945038 GO:0034237 protein kinase A regulatory subunit binding 6/2751 26/18639 0.230769230769231 1.56354332690211 0.175165915125398 0.722697108945038 GO:0050750 low-density lipoprotein particle receptor binding 6/2751 26/18639 0.230769230769231 1.56354332690211 0.175165915125398 0.722697108945038 GO:0097602 cullin family protein binding 6/2751 26/18639 0.230769230769231 1.56354332690211 0.175165915125398 0.722697108945038 GO:0120014 phospholipid transfer activity 6/2751 26/18639 0.230769230769231 1.56354332690211 0.175165915125398 0.722697108945038 GO:0098632 cell-cell adhesion mediator activity 11/2751 55/18639 0.2 1.35507088331516 0.179651111459377 0.738878552459884 GO:0015026 coreceptor activity 12/2751 61/18639 0.19672131147541 1.3328566065395 0.180844028725041 0.738937509251874 GO:0008173 RNA methyltransferase activity 13/2751 67/18639 0.194029850746269 1.31462100620127 0.181407389891696 0.738937509251874 GO:0030515 snoRNA binding 7/2751 32/18639 0.21875 1.48210877862595 0.183607948183011 0.738937509251874 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/2751 32/18639 0.21875 1.48210877862595 0.183607948183011 0.738937509251874 GO:0043425 bHLH transcription factor binding 7/2751 32/18639 0.21875 1.48210877862595 0.183607948183011 0.738937509251874 GO:0071813 lipoprotein particle binding 7/2751 32/18639 0.21875 1.48210877862595 0.183607948183011 0.738937509251874 GO:0071814 protein-lipid complex binding 7/2751 32/18639 0.21875 1.48210877862595 0.183607948183011 0.738937509251874 GO:0009931 calcium-dependent protein serine/threonine kinase activity 5/2751 21/18639 0.238095238095238 1.61317962299424 0.188251091480828 0.746179552939114 GO:0070182 DNA polymerase binding 5/2751 21/18639 0.238095238095238 1.61317962299424 0.188251091480828 0.746179552939114 GO:0072542 protein phosphatase activator activity 5/2751 21/18639 0.238095238095238 1.61317962299424 0.188251091480828 0.746179552939114 GO:0140312 cargo adaptor activity 5/2751 21/18639 0.238095238095238 1.61317962299424 0.188251091480828 0.746179552939114 GO:1904047 S-adenosyl-L-methionine binding 5/2751 21/18639 0.238095238095238 1.61317962299424 0.188251091480828 0.746179552939114 GO:0042887 amide transmembrane transporter activity 8/2751 38/18639 0.210526315789474 1.42639040348964 0.18904660472072 0.746343592317735 GO:1901981 phosphatidylinositol phosphate binding 32/2751 185/18639 0.172972972972973 1.17195319638068 0.189430195306254 0.746343592317735 GO:0003689 DNA clamp loader activity 28/2751 160/18639 0.175 1.18568702290076 0.190401241304703 0.747223319609515 GO:0043178 alcohol binding 17/2751 92/18639 0.184782608695652 1.25196766393248 0.192016953966914 0.747223319609515 GO:0016248 channel inhibitor activity 9/2751 44/18639 0.204545454545455 1.38586794884505 0.192501129594524 0.747223319609515 GO:0016790 thiolester hydrolase activity 9/2751 44/18639 0.204545454545455 1.38586794884505 0.192501129594524 0.747223319609515 GO:0019205 nucleobase-containing compound kinase activity 9/2751 44/18639 0.204545454545455 1.38586794884505 0.192501129594524 0.747223319609515 GO:1990782 protein tyrosine kinase binding 21/2751 117/18639 0.179487179487179 1.21608925425719 0.196507706220704 0.76052539988662 GO:0005159 insulin-like growth factor receptor binding 4/2751 16/18639 0.25 1.69383860414395 0.201687524527563 0.766688955205601 GO:0005324 long-chain fatty acid transmembrane transporter activity 4/2751 16/18639 0.25 1.69383860414395 0.201687524527563 0.766688955205601 GO:0005521 lamin binding 4/2751 16/18639 0.25 1.69383860414395 0.201687524527563 0.766688955205601 GO:0008296 3'-5'-DNA exonuclease activity 4/2751 16/18639 0.25 1.69383860414395 0.201687524527563 0.766688955205601 GO:0015562 efflux transmembrane transporter activity 4/2751 16/18639 0.25 1.69383860414395 0.201687524527563 0.766688955205601 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 4/2751 16/18639 0.25 1.69383860414395 0.201687524527563 0.766688955205601 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 7/2751 33/18639 0.212121212121212 1.43719639139486 0.205365579984925 0.766688955205601 GO:0140311 protein sequestering activity 7/2751 33/18639 0.212121212121212 1.43719639139486 0.205365579984925 0.766688955205601 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 8/2751 39/18639 0.205128205128205 1.38981629057965 0.20917418819391 0.766688955205601 GO:0141110 transporter inhibitor activity 9/2751 45/18639 0.2 1.35507088331516 0.211276857551153 0.766688955205601 GO:0003743 translation initiation factor activity 10/2751 51/18639 0.196078431372549 1.32850086599525 0.212214736971625 0.766688955205601 GO:0030544 Hsp70 protein binding 10/2751 51/18639 0.196078431372549 1.32850086599525 0.212214736971625 0.766688955205601 GO:0008013 beta-catenin binding 19/2751 106/18639 0.179245283018868 1.21445031995226 0.212815786040852 0.766688955205601 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 3/2751 11/18639 0.272727272727273 1.8478239317934 0.213878168906441 0.766688955205601 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 3/2751 11/18639 0.272727272727273 1.8478239317934 0.213878168906441 0.766688955205601 GO:0002162 dystroglycan binding 3/2751 11/18639 0.272727272727273 1.8478239317934 0.213878168906441 0.766688955205601 GO:0015205 nucleobase transmembrane transporter activity 3/2751 11/18639 0.272727272727273 1.8478239317934 0.213878168906441 0.766688955205601 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 3/2751 11/18639 0.272727272727273 1.8478239317934 0.213878168906441 0.766688955205601 GO:0019107 myristoyltransferase activity 3/2751 11/18639 0.272727272727273 1.8478239317934 0.213878168906441 0.766688955205601 GO:0032404 mismatch repair complex binding 3/2751 11/18639 0.272727272727273 1.8478239317934 0.213878168906441 0.766688955205601 GO:0034056 estrogen response element binding 3/2751 11/18639 0.272727272727273 1.8478239317934 0.213878168906441 0.766688955205601 GO:0034511 U3 snoRNA binding 3/2751 11/18639 0.272727272727273 1.8478239317934 0.213878168906441 0.766688955205601 GO:0035252 UDP-xylosyltransferase activity 3/2751 11/18639 0.272727272727273 1.8478239317934 0.213878168906441 0.766688955205601 GO:0042285 xylosyltransferase activity 3/2751 11/18639 0.272727272727273 1.8478239317934 0.213878168906441 0.766688955205601 GO:0097493 structural molecule activity conferring elasticity 3/2751 11/18639 0.272727272727273 1.8478239317934 0.213878168906441 0.766688955205601 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 3/2751 11/18639 0.272727272727273 1.8478239317934 0.213878168906441 0.766688955205601 GO:1900750 oligopeptide binding 3/2751 11/18639 0.272727272727273 1.8478239317934 0.213878168906441 0.766688955205601 GO:0031683 G-protein beta/gamma-subunit complex binding 5/2751 22/18639 0.227272727272727 1.5398532764945 0.216015136624104 0.77223939850361 GO:0140097 catalytic activity, acting on DNA 55/2751 336/18639 0.163690476190476 1.10906099080854 0.22086131181706 0.787418589956476 GO:0019789 SUMO transferase activity 6/2751 28/18639 0.214285714285714 1.45186166069481 0.223819319496692 0.795802024877128 GO:0016782 transferase activity, transferring sulphur-containing groups 13/2751 70/18639 0.185714285714286 1.2582801059355 0.226429834574887 0.802907953952032 GO:0019825 oxygen binding 7/2751 34/18639 0.205882352941176 1.39492590929502 0.228036373827183 0.804257318444258 GO:0052866 phosphatidylinositol phosphate phosphatase activity 7/2751 34/18639 0.205882352941176 1.39492590929502 0.228036373827183 0.804257318444258 GO:0004532 RNA exonuclease activity 8/2751 40/18639 0.2 1.35507088331516 0.230087092350901 0.807150441615994 GO:0030331 nuclear estrogen receptor binding 8/2751 40/18639 0.2 1.35507088331516 0.230087092350901 0.807150441615994 GO:0030291 protein serine/threonine kinase inhibitor activity 9/2751 46/18639 0.195652173913043 1.32561282063439 0.230744744286749 0.807298945344571 GO:0015278 intracellularly gated calcium channel activity 4/2751 17/18639 0.235294117647059 1.5942010391943 0.235026753415114 0.809011354846545 GO:0016018 cyclosporin A binding 4/2751 17/18639 0.235294117647059 1.5942010391943 0.235026753415114 0.809011354846545 GO:0046965 nuclear retinoid X receptor binding 4/2751 17/18639 0.235294117647059 1.5942010391943 0.235026753415114 0.809011354846545 GO:0070403 NAD+ binding 4/2751 17/18639 0.235294117647059 1.5942010391943 0.235026753415114 0.809011354846545 GO:0008238 exopeptidase activity 18/2751 102/18639 0.176470588235294 1.19565077939573 0.241385092923776 0.809011354846545 GO:0016887 ATP hydrolysis activity 67/2751 417/18639 0.160671462829736 1.08860610530115 0.242020218626645 0.809011354846545 GO:0008094 ATP-dependent activity, acting on DNA 35/2751 210/18639 0.166666666666667 1.12922573609596 0.242673847589627 0.809011354846545 GO:0008171 O-methyltransferase activity 5/2751 23/18639 0.217391304347826 1.47290313403822 0.244943742886948 0.809011354846545 GO:0031681 G-protein beta-subunit binding 5/2751 23/18639 0.217391304347826 1.47290313403822 0.244943742886948 0.809011354846545 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 5/2751 23/18639 0.217391304347826 1.47290313403822 0.244943742886948 0.809011354846545 GO:0061659 ubiquitin-like protein ligase activity 60/2751 372/18639 0.161290322580645 1.09279909944771 0.245896715782301 0.809011354846545 GO:0031593 polyubiquitin modification-dependent protein binding 11/2751 59/18639 0.186440677966102 1.26320167088701 0.247265458972347 0.809011354846545 GO:0008146 sulfotransferase activity 10/2751 53/18639 0.188679245283019 1.27836875784449 0.249282946777638 0.809011354846545 GO:0140296 general transcription initiation factor binding 10/2751 53/18639 0.188679245283019 1.27836875784449 0.249282946777638 0.809011354846545 GO:0061630 ubiquitin protein ligase activity 57/2751 353/18639 0.161473087818697 1.09403739871054 0.249524311649345 0.809011354846545 GO:0016417 S-acyltransferase activity 6/2751 29/18639 0.206896551724138 1.40179746549844 0.249637257903657 0.809011354846545 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 6/2751 29/18639 0.206896551724138 1.40179746549844 0.249637257903657 0.809011354846545 GO:0140359 ABC-type transporter activity 9/2751 47/18639 0.191489361702128 1.29740829253579 0.250835683635332 0.809011354846545 GO:0000175 3'-5'-RNA exonuclease activity 7/2751 35/18639 0.2 1.35507088331516 0.251505045225981 0.809011354846545 GO:0016229 steroid dehydrogenase activity 7/2751 35/18639 0.2 1.35507088331516 0.251505045225981 0.809011354846545 GO:0034061 DNA polymerase activity 7/2751 35/18639 0.2 1.35507088331516 0.251505045225981 0.809011354846545 GO:0043015 gamma-tubulin binding 7/2751 35/18639 0.2 1.35507088331516 0.251505045225981 0.809011354846545 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 8/2751 41/18639 0.195121951219512 1.32202037396601 0.251697573742911 0.809011354846545 GO:0042169 SH2 domain binding 8/2751 41/18639 0.195121951219512 1.32202037396601 0.251697573742911 0.809011354846545 GO:0000995 RNA polymerase III general transcription initiation factor activity 3/2751 12/18639 0.25 1.69383860414395 0.255899170930881 0.809011354846545 GO:0003720 telomerase activity 3/2751 12/18639 0.25 1.69383860414395 0.255899170930881 0.809011354846545 GO:0004300 enoyl-CoA hydratase activity 3/2751 12/18639 0.25 1.69383860414395 0.255899170930881 0.809011354846545 GO:0005165 neurotrophin receptor binding 3/2751 12/18639 0.25 1.69383860414395 0.255899170930881 0.809011354846545 GO:0008504 monoamine transmembrane transporter activity 3/2751 12/18639 0.25 1.69383860414395 0.255899170930881 0.809011354846545 GO:0016273 arginine N-methyltransferase activity 3/2751 12/18639 0.25 1.69383860414395 0.255899170930881 0.809011354846545 GO:0016274 protein-arginine N-methyltransferase activity 3/2751 12/18639 0.25 1.69383860414395 0.255899170930881 0.809011354846545 GO:0017166 vinculin binding 3/2751 12/18639 0.25 1.69383860414395 0.255899170930881 0.809011354846545 GO:0035014 phosphatidylinositol 3-kinase regulator activity 3/2751 12/18639 0.25 1.69383860414395 0.255899170930881 0.809011354846545 GO:0035497 cAMP response element binding 3/2751 12/18639 0.25 1.69383860414395 0.255899170930881 0.809011354846545 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 3/2751 12/18639 0.25 1.69383860414395 0.255899170930881 0.809011354846545 GO:0070679 inositol 1,4,5 trisphosphate binding 3/2751 12/18639 0.25 1.69383860414395 0.255899170930881 0.809011354846545 GO:0097371 MDM2/MDM4 family protein binding 3/2751 12/18639 0.25 1.69383860414395 0.255899170930881 0.809011354846545 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 3/2751 12/18639 0.25 1.69383860414395 0.255899170930881 0.809011354846545 GO:1990247 N6-methyladenosine-containing RNA reader activity 3/2751 12/18639 0.25 1.69383860414395 0.255899170930881 0.809011354846545 GO:1990817 poly(A) RNA polymerase activity 3/2751 12/18639 0.25 1.69383860414395 0.255899170930881 0.809011354846545 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 11/2751 60/18639 0.183333333333333 1.24214830970556 0.265462521965696 0.83722795389181 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4/2751 18/18639 0.222222222222222 1.50563431479462 0.269538254389491 0.841951286195287 GO:0070628 proteasome binding 4/2751 18/18639 0.222222222222222 1.50563431479462 0.269538254389491 0.841951286195287 GO:0098641 cadherin binding involved in cell-cell adhesion 4/2751 18/18639 0.222222222222222 1.50563431479462 0.269538254389491 0.841951286195287 GO:0016835 carbon-oxygen lyase activity 14/2751 79/18639 0.177215189873418 1.20069571939318 0.271228932834541 0.841951286195287 GO:0046332 SMAD binding 14/2751 79/18639 0.177215189873418 1.20069571939318 0.271228932834541 0.841951286195287 GO:0038187 pattern recognition receptor activity 9/2751 48/18639 0.1875 1.27037895310796 0.271476964787037 0.841951286195287 GO:0016779 nucleotidyltransferase activity 23/2751 136/18639 0.169117647058824 1.14583199692091 0.271872957663736 0.841951286195287 GO:0001091 RNA polymerase II general transcription initiation factor binding 5/2751 24/18639 0.208333333333333 1.41153217011996 0.274797039914973 0.841951286195287 GO:0005540 hyaluronic acid binding 5/2751 24/18639 0.208333333333333 1.41153217011996 0.274797039914973 0.841951286195287 GO:0035035 histone acetyltransferase binding 5/2751 24/18639 0.208333333333333 1.41153217011996 0.274797039914973 0.841951286195287 GO:0004521 RNA endonuclease activity 13/2751 73/18639 0.178082191780822 1.20656996459569 0.275476096653031 0.841951286195287 GO:0008187 poly-pyrimidine tract binding 6/2751 30/18639 0.2 1.35507088331516 0.276232381922932 0.841951286195287 GO:0035925 mRNA 3'-UTR AU-rich region binding 6/2751 30/18639 0.2 1.35507088331516 0.276232381922932 0.841951286195287 GO:0070566 adenylyltransferase activity 6/2751 30/18639 0.2 1.35507088331516 0.276232381922932 0.841951286195287 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 22/2751 130/18639 0.169230769230769 1.14659843972821 0.276586131364458 0.841951286195287 GO:1902936 phosphatidylinositol bisphosphate binding 19/2751 111/18639 0.171171171171171 1.15974535058505 0.277883042665879 0.843941092540817 GO:0140996 histone H3 kinase activity 57/2751 357/18639 0.159663865546218 1.08177927659613 0.279201415776121 0.845986737871295 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 15/2751 86/18639 0.174418604651163 1.18174786335624 0.282611627635728 0.852462274681042 GO:0016836 hydro-lyase activity 11/2751 61/18639 0.180327868852459 1.22178522266121 0.28407859047864 0.852462274681042 GO:0140313 molecular sequestering activity 10/2751 55/18639 0.181818181818182 1.2318826211956 0.288373616961099 0.852462274681042 GO:0031072 heat shock protein binding 22/2751 131/18639 0.16793893129771 1.13784577988296 0.289287364811458 0.852462274681042 GO:0005200 structural constituent of cytoskeleton 19/2751 112/18639 0.169642857142857 1.14939048138339 0.291686308442642 0.852462274681042 GO:0035254 glutamate receptor binding 9/2751 49/18639 0.183673469387755 1.24445285202412 0.292593225233922 0.852462274681042 GO:0060590 ATPase regulator activity 9/2751 49/18639 0.183673469387755 1.24445285202412 0.292593225233922 0.852462274681042 GO:0051219 phosphoprotein binding 16/2751 93/18639 0.172043010752688 1.16565237274422 0.293051683413782 0.852462274681042 GO:0051015 actin filament binding 34/2751 209/18639 0.162679425837321 1.1022107663329 0.295785325378443 0.852462274681042 GO:0048156 tau protein binding 8/2751 43/18639 0.186046511627907 1.26053105424666 0.296640988149576 0.852462274681042 GO:0000510 H3-H4 histone complex chaperone activity 25/2751 151/18639 0.165562913907285 1.12174741996288 0.298266012534973 0.852462274681042 GO:0140584 chromatin extrusion motor activity 25/2751 151/18639 0.165562913907285 1.12174741996288 0.298266012534973 0.852462274681042 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 25/2751 151/18639 0.165562913907285 1.12174741996288 0.298266012534973 0.852462274681042 GO:0140849 ATP-dependent H2AZ histone chaperone activity 25/2751 151/18639 0.165562913907285 1.12174741996288 0.298266012534973 0.852462274681042 GO:0003964 RNA-directed DNA polymerase activity 3/2751 13/18639 0.230769230769231 1.56354332690211 0.298885255076225 0.852462274681042 GO:0005035 death receptor activity 3/2751 13/18639 0.230769230769231 1.56354332690211 0.298885255076225 0.852462274681042 GO:0005542 folic acid binding 3/2751 13/18639 0.230769230769231 1.56354332690211 0.298885255076225 0.852462274681042 GO:0008035 high-density lipoprotein particle binding 3/2751 13/18639 0.230769230769231 1.56354332690211 0.298885255076225 0.852462274681042 GO:0019104 DNA N-glycosylase activity 3/2751 13/18639 0.230769230769231 1.56354332690211 0.298885255076225 0.852462274681042 GO:0031994 insulin-like growth factor I binding 3/2751 13/18639 0.230769230769231 1.56354332690211 0.298885255076225 0.852462274681042 GO:0097157 pre-mRNA intronic binding 3/2751 13/18639 0.230769230769231 1.56354332690211 0.298885255076225 0.852462274681042 GO:0035173 histone kinase activity 57/2751 360/18639 0.158333333333333 1.07276444929117 0.30236313116323 0.852462274681042 GO:0016878 acid-thiol ligase activity 6/2751 31/18639 0.193548387096774 1.31135891933725 0.303438897959803 0.852462274681042 GO:0070325 lipoprotein particle receptor binding 6/2751 31/18639 0.193548387096774 1.31135891933725 0.303438897959803 0.852462274681042 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 4/2751 19/18639 0.210526315789474 1.42639040348964 0.304842624711209 0.852462274681042 GO:0005520 insulin-like growth factor binding 4/2751 19/18639 0.210526315789474 1.42639040348964 0.304842624711209 0.852462274681042 GO:0015245 fatty acid transmembrane transporter activity 4/2751 19/18639 0.210526315789474 1.42639040348964 0.304842624711209 0.852462274681042 GO:0046624 sphingolipid transporter activity 4/2751 19/18639 0.210526315789474 1.42639040348964 0.304842624711209 0.852462274681042 GO:0050145 nucleoside monophosphate kinase activity 4/2751 19/18639 0.210526315789474 1.42639040348964 0.304842624711209 0.852462274681042 GO:0001848 complement binding 5/2751 25/18639 0.2 1.35507088331516 0.305336409490331 0.852462274681042 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 5/2751 25/18639 0.2 1.35507088331516 0.305336409490331 0.852462274681042 GO:0017025 TBP-class protein binding 5/2751 25/18639 0.2 1.35507088331516 0.305336409490331 0.852462274681042 GO:0019211 phosphatase activator activity 5/2751 25/18639 0.2 1.35507088331516 0.305336409490331 0.852462274681042 GO:0019706 protein-cysteine S-palmitoyltransferase activity 5/2751 25/18639 0.2 1.35507088331516 0.305336409490331 0.852462274681042 GO:0019707 protein-cysteine S-acyltransferase activity 5/2751 25/18639 0.2 1.35507088331516 0.305336409490331 0.852462274681042 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 5/2751 25/18639 0.2 1.35507088331516 0.305336409490331 0.852462274681042 GO:0008237 metallopeptidase activity 30/2751 184/18639 0.16304347826087 1.10467735052866 0.305914645658544 0.852462274681042 GO:0019787 ubiquitin-like protein transferase activity 75/2751 479/18639 0.156576200417537 1.06085925102961 0.306028758669795 0.852462274681042 GO:0141003 histone H2AX kinase activity 56/2751 354/18639 0.15819209039548 1.07180747832837 0.30684440559095 0.852923432490098 GO:0015616 DNA translocase activity 25/2751 152/18639 0.164473684210526 1.11436750272628 0.310410168472338 0.858024973323727 GO:0140674 ATP-dependent histone chaperone activity 25/2751 152/18639 0.164473684210526 1.11436750272628 0.310410168472338 0.858024973323727 GO:0005085 guanyl-nucleotide exchange factor activity 37/2751 230/18639 0.160869565217391 1.08994831918828 0.310641663360343 0.858024973323727 GO:0043014 alpha-tubulin binding 8/2751 44/18639 0.181818181818182 1.2318826211956 0.319783178939587 0.881419182287265 GO:0005507 copper ion binding 11/2751 63/18639 0.174603174603175 1.18299839019577 0.322355449674187 0.88575062815153 GO:0061775 cohesin loader activity 25/2751 153/18639 0.163398692810458 1.10708405499604 0.322704878244231 0.88575062815153 GO:0000146 microfilament motor activity 7/2751 38/18639 0.184210526315789 1.24809160305344 0.325487268053376 0.88781558354684 GO:0005109 frizzled binding 7/2751 38/18639 0.184210526315789 1.24809160305344 0.325487268053376 0.88781558354684 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 7/2751 38/18639 0.184210526315789 1.24809160305344 0.325487268053376 0.88781558354684 GO:0017022 myosin binding 13/2751 76/18639 0.171052631578947 1.15894220283533 0.327563324544993 0.891624651043632 GO:0051087 protein-folding chaperone binding 22/2751 134/18639 0.164179104477612 1.11237162063185 0.328493142288073 0.891806086938548 GO:0015932 nucleobase-containing compound transmembrane transporter activity 10/2751 57/18639 0.175438596491228 1.1886586695747 0.328989440608428 0.891806086938548 GO:0003727 single-stranded RNA binding 15/2751 89/18639 0.168539325842697 1.14191366571502 0.330910405920038 0.892556263358455 GO:0070717 poly-purine tract binding 6/2751 32/18639 0.1875 1.27037895310796 0.331092194062139 0.892556263358455 GO:0097110 scaffold protein binding 12/2751 70/18639 0.171428571428571 1.16148932855585 0.33454433281519 0.892556263358455 GO:0005048 signal sequence binding 9/2751 51/18639 0.176470588235294 1.19565077939573 0.335941518845496 0.892556263358455 GO:0004529 DNA exonuclease activity 5/2751 26/18639 0.192307692307692 1.30295277241842 0.336329384339125 0.892556263358455 GO:0008143 poly(A) binding 5/2751 26/18639 0.192307692307692 1.30295277241842 0.336329384339125 0.892556263358455 GO:0008157 protein phosphatase 1 binding 5/2751 26/18639 0.192307692307692 1.30295277241842 0.336329384339125 0.892556263358455 GO:0050681 nuclear androgen receptor binding 5/2751 26/18639 0.192307692307692 1.30295277241842 0.336329384339125 0.892556263358455 GO:0001540 amyloid-beta binding 14/2751 83/18639 0.168674698795181 1.14283086544652 0.337973211950055 0.892556263358455 GO:0008135 translation factor activity, RNA binding 14/2751 83/18639 0.168674698795181 1.14283086544652 0.337973211950055 0.892556263358455 GO:0030165 PDZ domain binding 14/2751 83/18639 0.168674698795181 1.14283086544652 0.337973211950055 0.892556263358455 GO:0016829 lyase activity 32/2751 200/18639 0.16 1.08405670665213 0.33857790524088 0.892556263358455 GO:0031418 L-ascorbic acid binding 4/2751 20/18639 0.2 1.35507088331516 0.340581544999259 0.892556263358455 GO:0004065 arylsulfatase activity 3/2751 14/18639 0.214285714285714 1.45186166069481 0.342191921089408 0.892556263358455 GO:0008195 phosphatidate phosphatase activity 3/2751 14/18639 0.214285714285714 1.45186166069481 0.342191921089408 0.892556263358455 GO:0008474 palmitoyl-(protein) hydrolase activity 3/2751 14/18639 0.214285714285714 1.45186166069481 0.342191921089408 0.892556263358455 GO:0032036 myosin heavy chain binding 3/2751 14/18639 0.214285714285714 1.45186166069481 0.342191921089408 0.892556263358455 GO:0042813 Wnt receptor activity 3/2751 14/18639 0.214285714285714 1.45186166069481 0.342191921089408 0.892556263358455 GO:0098599 palmitoyl hydrolase activity 3/2751 14/18639 0.214285714285714 1.45186166069481 0.342191921089408 0.892556263358455 GO:0000217 DNA secondary structure binding 7/2751 39/18639 0.179487179487179 1.21608925425719 0.350930754272634 0.913534026995429 GO:0180051 translation factor activity 14/2751 84/18639 0.166666666666667 1.12922573609596 0.35521100686187 0.921467987407021 GO:0044325 transmembrane transporter binding 22/2751 136/18639 0.161764705882353 1.09601321444608 0.355383232948135 0.921467987407021 GO:0005080 protein kinase C binding 9/2751 52/18639 0.173076923076923 1.17265749517658 0.35801774115216 0.923625983186133 GO:0030159 signaling receptor complex adaptor activity 9/2751 52/18639 0.173076923076923 1.17265749517658 0.35801774115216 0.923625983186133 GO:0071889 14-3-3 protein binding 6/2751 33/18639 0.181818181818182 1.2318826211956 0.359031441634854 0.923625983186133 GO:0140416 transcription regulator inhibitor activity 6/2751 33/18639 0.181818181818182 1.2318826211956 0.359031441634854 0.923625983186133 GO:0016798 hydrolase activity, acting on glycosyl bonds 21/2751 130/18639 0.161538461538462 1.09448032883147 0.362698633148533 0.931234063974315 GO:0072341 modified amino acid binding 15/2751 91/18639 0.164835164835165 1.11681666207293 0.364113247289966 0.933040196180537 GO:0008266 poly(U) RNA binding 5/2751 27/18639 0.185185185185185 1.25469526232885 0.367553660211977 0.938191443965202 GO:0035255 ionotropic glutamate receptor binding 5/2751 27/18639 0.185185185185185 1.25469526232885 0.367553660211977 0.938191443965202 GO:0031625 ubiquitin protein ligase binding 47/2751 302/18639 0.155629139072848 1.05444257476511 0.370030084847287 0.942678585086681 GO:0001846 opsonin binding 4/2751 21/18639 0.19047619047619 1.29054369839539 0.376424004650656 0.949303886093457 GO:0008373 sialyltransferase activity 4/2751 21/18639 0.19047619047619 1.29054369839539 0.376424004650656 0.949303886093457 GO:0010314 phosphatidylinositol-5-phosphate binding 4/2751 21/18639 0.19047619047619 1.29054369839539 0.376424004650656 0.949303886093457 GO:0004842 ubiquitin-protein transferase activity 69/2751 449/18639 0.153674832962138 1.04120145822657 0.376751451852751 0.949303886093457 GO:0140713 histone chaperone activity 26/2751 164/18639 0.158536585365854 1.07414155384738 0.378449288791322 0.949303886093457 GO:0016755 aminoacyltransferase activity 76/2751 496/18639 0.153225806451613 1.03815914447532 0.379328794225505 0.949303886093457 GO:0051018 protein kinase A binding 9/2751 53/18639 0.169811320754717 1.15053188206004 0.380258949092404 0.949303886093457 GO:0000774 adenyl-nucleotide exchange factor activity 3/2751 15/18639 0.2 1.35507088331516 0.385261805241883 0.949303886093457 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 3/2751 15/18639 0.2 1.35507088331516 0.385261805241883 0.949303886093457 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3/2751 15/18639 0.2 1.35507088331516 0.385261805241883 0.949303886093457 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/2751 15/18639 0.2 1.35507088331516 0.385261805241883 0.949303886093457 GO:0016846 carbon-sulfur lyase activity 3/2751 15/18639 0.2 1.35507088331516 0.385261805241883 0.949303886093457 GO:0017081 chloride channel regulator activity 3/2751 15/18639 0.2 1.35507088331516 0.385261805241883 0.949303886093457 GO:0050780 dopamine receptor binding 3/2751 15/18639 0.2 1.35507088331516 0.385261805241883 0.949303886093457 GO:0061578 K63-linked deubiquitinase activity 3/2751 15/18639 0.2 1.35507088331516 0.385261805241883 0.949303886093457 GO:0008175 tRNA methyltransferase activity 6/2751 34/18639 0.176470588235294 1.19565077939573 0.387101813307926 0.949303886093457 GO:0015035 protein-disulfide reductase activity 6/2751 34/18639 0.176470588235294 1.19565077939573 0.387101813307926 0.949303886093457 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 6/2751 34/18639 0.176470588235294 1.19565077939573 0.387101813307926 0.949303886093457 GO:0030332 cyclin binding 6/2751 34/18639 0.176470588235294 1.19565077939573 0.387101813307926 0.949303886093457 GO:0090482 vitamin transmembrane transporter activity 6/2751 34/18639 0.176470588235294 1.19565077939573 0.387101813307926 0.949303886093457 GO:0043539 protein serine/threonine kinase activator activity 12/2751 73/18639 0.164383561643836 1.11375689039602 0.391228388812301 0.957633668137572 GO:0050698 proteoglycan sulfotransferase activity 5/2751 28/18639 0.178571428571429 1.20988471724568 0.398800256019649 0.965129174535874 GO:0051019 mitogen-activated protein kinase binding 5/2751 28/18639 0.178571428571429 1.20988471724568 0.398800256019649 0.965129174535874 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 5/2751 28/18639 0.178571428571429 1.20988471724568 0.398800256019649 0.965129174535874 GO:0061650 ubiquitin-like protein conjugating enzyme activity 7/2751 41/18639 0.170731707317073 1.15676782722026 0.402272105140642 0.965129174535874 GO:0003684 damaged DNA binding 12/2751 74/18639 0.162162162162162 1.09870612160689 0.410326895565938 0.965129174535874 GO:0019001 guanyl nucleotide binding 61/2751 400/18639 0.1525 1.03324154852781 0.411502670671013 0.965129174535874 GO:0032561 guanyl ribonucleotide binding 61/2751 400/18639 0.1525 1.03324154852781 0.411502670671013 0.965129174535874 GO:0016881 acid-amino acid ligase activity 4/2751 22/18639 0.181818181818182 1.2318826211956 0.412070419767667 0.965129174535874 GO:0032931 histone H3K56 acetyltransferase activity 4/2751 22/18639 0.181818181818182 1.2318826211956 0.412070419767667 0.965129174535874 GO:0034062 5'-3' RNA polymerase activity 4/2751 22/18639 0.181818181818182 1.2318826211956 0.412070419767667 0.965129174535874 GO:0043992 histone H3K9 acetyltransferase activity 4/2751 22/18639 0.181818181818182 1.2318826211956 0.412070419767667 0.965129174535874 GO:0043993 histone H3K18 acetyltransferase activity 4/2751 22/18639 0.181818181818182 1.2318826211956 0.412070419767667 0.965129174535874 GO:0043994 histone H3K23 acetyltransferase activity 4/2751 22/18639 0.181818181818182 1.2318826211956 0.412070419767667 0.965129174535874 GO:0043999 histone H2AK5 acetyltransferase activity 4/2751 22/18639 0.181818181818182 1.2318826211956 0.412070419767667 0.965129174535874 GO:0044012 histone H2AK9 acetyltransferase activity 4/2751 22/18639 0.181818181818182 1.2318826211956 0.412070419767667 0.965129174535874 GO:0044014 histone H2BK5 acetyltransferase activity 4/2751 22/18639 0.181818181818182 1.2318826211956 0.412070419767667 0.965129174535874 GO:0044015 histone H2BK12 acetyltransferase activity 4/2751 22/18639 0.181818181818182 1.2318826211956 0.412070419767667 0.965129174535874 GO:0044016 histone H3K4 acetyltransferase activity 4/2751 22/18639 0.181818181818182 1.2318826211956 0.412070419767667 0.965129174535874 GO:0044017 histone H3K27 acetyltransferase activity 4/2751 22/18639 0.181818181818182 1.2318826211956 0.412070419767667 0.965129174535874 GO:0044018 histone H3K36 acetyltransferase activity 4/2751 22/18639 0.181818181818182 1.2318826211956 0.412070419767667 0.965129174535874 GO:0046972 histone H4K16 acetyltransferase activity 4/2751 22/18639 0.181818181818182 1.2318826211956 0.412070419767667 0.965129174535874 GO:0097747 RNA polymerase activity 4/2751 22/18639 0.181818181818182 1.2318826211956 0.412070419767667 0.965129174535874 GO:0140908 histone H3K122 acetyltransferase activity 4/2751 22/18639 0.181818181818182 1.2318826211956 0.412070419767667 0.965129174535874 GO:0004519 endonuclease activity 20/2751 127/18639 0.15748031496063 1.06698494749225 0.413850630132151 0.965129174535874 GO:0016879 ligase activity, forming carbon-nitrogen bonds 8/2751 48/18639 0.166666666666667 1.12922573609596 0.41459486415563 0.965129174535874 GO:0005154 epidermal growth factor receptor binding 6/2751 35/18639 0.171428571428571 1.16148932855585 0.415156317049019 0.965129174535874 GO:0005516 calmodulin binding 32/2751 207/18639 0.154589371980676 1.04739778420495 0.417378504098634 0.965129174535874 GO:0033218 amide binding 38/2751 247/18639 0.153846153846154 1.04236221793474 0.417437718272261 0.965129174535874 GO:0001618 virus receptor activity 13/2751 81/18639 0.160493827160494 1.087402560685 0.418176002743917 0.965129174535874 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 3/2751 16/18639 0.1875 1.27037895310796 0.427625100791342 0.965129174535874 GO:0004707 MAP kinase activity 3/2751 16/18639 0.1875 1.27037895310796 0.427625100791342 0.965129174535874 GO:0004708 MAP kinase kinase activity 3/2751 16/18639 0.1875 1.27037895310796 0.427625100791342 0.965129174535874 GO:0008307 structural constituent of muscle 7/2751 42/18639 0.166666666666667 1.12922573609596 0.427943775436154 0.965129174535874 GO:0019003 GDP binding 12/2751 75/18639 0.16 1.08405670665213 0.429450369608958 0.965129174535874 GO:0043236 laminin binding 5/2751 29/18639 0.172413793103448 1.16816455458203 0.429875880627147 0.965129174535874 GO:0099604 ligand-gated calcium channel activity 5/2751 29/18639 0.172413793103448 1.16816455458203 0.429875880627147 0.965129174535874 GO:0044389 ubiquitin-like protein ligase binding 49/2751 322/18639 0.152173913043478 1.03103219382675 0.431716573707044 0.965129174535874 GO:0046982 protein heterodimerization activity 56/2751 369/18639 0.151761517615176 1.02823806864023 0.432443991598174 0.965129174535874 GO:0140272 exogenous protein binding 13/2751 82/18639 0.158536585365854 1.07414155384738 0.436499603418878 0.965129174535874 GO:0016409 palmitoyltransferase activity 6/2751 36/18639 0.166666666666667 1.12922573609596 0.443057257920246 0.965129174535874 GO:0045505 dynein intermediate chain binding 6/2751 36/18639 0.166666666666667 1.12922573609596 0.443057257920246 0.965129174535874 GO:0000182 rDNA binding 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0001094 TFIID-class transcription factor complex binding 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0004955 prostaglandin receptor activity 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0005337 nucleoside transmembrane transporter activity 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0005381 iron ion transmembrane transporter activity 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0008519 ammonium channel activity 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0015203 polyamine transmembrane transporter activity 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0015279 store-operated calcium channel activity 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0016427 tRNA (cytidine) methyltransferase activity 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0032356 oxidized DNA binding 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0035256 G protein-coupled glutamate receptor binding 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0043422 protein kinase B binding 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0045322 unmethylated CpG binding 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0050815 phosphoserine residue binding 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0070097 delta-catenin binding 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0140135 mechanosensitive monoatomic cation channel activity 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0141109 transporter activator activity 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:1905394 retromer complex binding 2/2751 10/18639 0.2 1.35507088331516 0.446852309301347 0.965129174535874 GO:0003887 DNA-directed DNA polymerase activity 4/2751 23/18639 0.173913043478261 1.17832250723057 0.447254983321502 0.965129174535874 GO:0043274 phospholipase binding 4/2751 23/18639 0.173913043478261 1.17832250723057 0.447254983321502 0.965129174535874 GO:0044013 histone H2B acetyltransferase activity 4/2751 23/18639 0.173913043478261 1.17832250723057 0.447254983321502 0.965129174535874 GO:0099186 structural constituent of postsynapse 4/2751 23/18639 0.173913043478261 1.17832250723057 0.447254983321502 0.965129174535874 GO:0140103 catalytic activity, acting on a glycoprotein 4/2751 23/18639 0.173913043478261 1.17832250723057 0.447254983321502 0.965129174535874 GO:0005525 GTP binding 57/2751 378/18639 0.150793650793651 1.02168042789635 0.452132809638512 0.974052949500373 GO:0004712 protein serine/threonine/tyrosine kinase activity 7/2751 43/18639 0.162790697674419 1.10296467246583 0.453474872964099 0.975342677588357 GO:0001968 fibronectin binding 5/2751 30/18639 0.166666666666667 1.12922573609596 0.460604580367989 0.982623104785044 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 5/2751 30/18639 0.166666666666667 1.12922573609596 0.460604580367989 0.982623104785044 GO:0016769 transferase activity, transferring nitrogenous groups 5/2751 30/18639 0.166666666666667 1.12922573609596 0.460604580367989 0.982623104785044 GO:0048019 receptor antagonist activity 5/2751 30/18639 0.166666666666667 1.12922573609596 0.460604580367989 0.982623104785044 GO:0098918 structural constituent of synapse 5/2751 30/18639 0.166666666666667 1.12922573609596 0.460604580367989 0.982623104785044 GO:0003724 RNA helicase activity 12/2751 77/18639 0.155844155844156 1.05589938959623 0.467595139315545 0.985884265866323 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 3/2751 17/18639 0.176470588235294 1.19565077939573 0.468896175229105 0.985884265866323 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/2751 17/18639 0.176470588235294 1.19565077939573 0.468896175229105 0.985884265866323 GO:0008484 sulfuric ester hydrolase activity 3/2751 17/18639 0.176470588235294 1.19565077939573 0.468896175229105 0.985884265866323 GO:0008569 minus-end-directed microtubule motor activity 3/2751 17/18639 0.176470588235294 1.19565077939573 0.468896175229105 0.985884265866323 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/2751 17/18639 0.176470588235294 1.19565077939573 0.468896175229105 0.985884265866323 GO:0031489 myosin V binding 3/2751 17/18639 0.176470588235294 1.19565077939573 0.468896175229105 0.985884265866323 GO:0032183 SUMO binding 3/2751 17/18639 0.176470588235294 1.19565077939573 0.468896175229105 0.985884265866323 GO:0051787 misfolded protein binding 3/2751 17/18639 0.176470588235294 1.19565077939573 0.468896175229105 0.985884265866323 GO:0005262 calcium channel activity 20/2751 131/18639 0.152671755725191 1.03440525443905 0.472271699558305 0.98671966023572 GO:0051117 ATPase binding 13/2751 84/18639 0.154761904761905 1.04856675494625 0.473031483167535 0.98671966023572 GO:0030547 signaling receptor inhibitor activity 7/2751 44/18639 0.159090909090909 1.07789729354615 0.478767896157926 0.98671966023572 GO:0030246 carbohydrate binding 42/2751 280/18639 0.15 1.01630316248637 0.480512943356933 0.98671966023572 GO:0140299 molecular sensor activity 11/2751 71/18639 0.154929577464789 1.04970279693428 0.481439308655826 0.98671966023572 GO:0004622 lysophospholipase activity 4/2751 24/18639 0.166666666666667 1.12922573609596 0.481746572002808 0.98671966023572 GO:0030215 semaphorin receptor binding 4/2751 24/18639 0.166666666666667 1.12922573609596 0.481746572002808 0.98671966023572 GO:0043998 histone H2A acetyltransferase activity 4/2751 24/18639 0.166666666666667 1.12922573609596 0.481746572002808 0.98671966023572 GO:0060229 lipase activator activity 4/2751 24/18639 0.166666666666667 1.12922573609596 0.481746572002808 0.98671966023572 GO:0070840 dynein complex binding 4/2751 24/18639 0.166666666666667 1.12922573609596 0.481746572002808 0.98671966023572 GO:0140612 DNA damage sensor activity 4/2751 24/18639 0.166666666666667 1.12922573609596 0.481746572002808 0.98671966023572 GO:0016830 carbon-carbon lyase activity 8/2751 51/18639 0.156862745098039 1.0628006927962 0.485541526222923 0.98671966023572 GO:0042393 histone binding 37/2751 247/18639 0.149797570850202 1.01493163325224 0.488540540694682 0.98671966023572 GO:0005310 dicarboxylic acid transmembrane transporter activity 5/2751 31/18639 0.161290322580645 1.09279909944771 0.490828750061871 0.98671966023572 GO:0070273 phosphatidylinositol-4-phosphate binding 5/2751 31/18639 0.161290322580645 1.09279909944771 0.490828750061871 0.98671966023572 GO:0140030 modification-dependent protein binding 26/2751 173/18639 0.15028901734104 1.01826135740445 0.492937327229619 0.98671966023572 GO:0052689 carboxylic ester hydrolase activity 14/2751 92/18639 0.152173913043478 1.03103219382675 0.495422174588715 0.98671966023572 GO:0043531 ADP binding 6/2751 38/18639 0.157894736842105 1.06979280261723 0.497900487421107 0.98671966023572 GO:0001851 complement component C3b binding 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0004523 RNA-DNA hybrid ribonuclease activity 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0004954 prostanoid receptor activity 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0005225 volume-sensitive anion channel activity 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0005536 D-glucose binding 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0008172 S-methyltransferase activity 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0008271 secondary active sulfate transmembrane transporter activity 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0008432 JUN kinase binding 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0008526 phosphatidylinositol transfer activity 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0015217 ADP transmembrane transporter activity 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0019864 IgG binding 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0032794 GTPase activating protein binding 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0034713 type I transforming growth factor beta receptor binding 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0045294 alpha-catenin binding 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0070697 activin receptor binding 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0140031 phosphorylation-dependent protein binding 2/2751 11/18639 0.181818181818182 1.2318826211956 0.498624340500215 0.98671966023572 GO:0046915 transition metal ion transmembrane transporter activity 7/2751 45/18639 0.155555555555556 1.05394402035623 0.503732823442277 0.988893778265038 GO:0008186 ATP-dependent activity, acting on RNA 12/2751 79/18639 0.151898734177215 1.02916775947987 0.505323897147132 0.988893778265038 GO:0015085 calcium ion transmembrane transporter activity 22/2751 147/18639 0.149659863945578 1.01399862016781 0.507443284581736 0.988893778265038 GO:0000900 mRNA regulatory element binding translation repressor activity 3/2751 18/18639 0.166666666666667 1.12922573609596 0.508767759397028 0.988893778265038 GO:0003746 translation elongation factor activity 3/2751 18/18639 0.166666666666667 1.12922573609596 0.508767759397028 0.988893778265038 GO:0004970 glutamate-gated receptor activity 3/2751 18/18639 0.166666666666667 1.12922573609596 0.508767759397028 0.988893778265038 GO:0008308 voltage-gated monoatomic anion channel activity 3/2751 18/18639 0.166666666666667 1.12922573609596 0.508767759397028 0.988893778265038 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 3/2751 18/18639 0.166666666666667 1.12922573609596 0.508767759397028 0.988893778265038 GO:0017075 syntaxin-1 binding 3/2751 18/18639 0.166666666666667 1.12922573609596 0.508767759397028 0.988893778265038 GO:0050811 GABA receptor binding 3/2751 18/18639 0.166666666666667 1.12922573609596 0.508767759397028 0.988893778265038 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 3/2751 18/18639 0.166666666666667 1.12922573609596 0.508767759397028 0.988893778265038 GO:1901611 phosphatidylglycerol binding 3/2751 18/18639 0.166666666666667 1.12922573609596 0.508767759397028 0.988893778265038 GO:0036002 pre-mRNA binding 9/2751 59/18639 0.152542372881356 1.03352863981665 0.513119524365992 0.992037760753904 GO:0070888 E-box binding 9/2751 59/18639 0.152542372881356 1.03352863981665 0.513119524365992 0.992037760753904 GO:0003924 GTPase activity 49/2751 331/18639 0.148036253776435 1.0029980858375 0.514970855426283 0.992037760753904 GO:0008139 nuclear localization sequence binding 4/2751 25/18639 0.16 1.08405670665213 0.51534850771947 0.992037760753904 GO:0042974 nuclear retinoic acid receptor binding 4/2751 25/18639 0.16 1.08405670665213 0.51534850771947 0.992037760753904 GO:0047617 fatty acyl-CoA hydrolase activity 4/2751 25/18639 0.16 1.08405670665213 0.51534850771947 0.992037760753904 GO:0016247 channel regulator activity 25/2751 168/18639 0.148809523809524 1.0082372643714 0.515678165269941 0.992037760753904 GO:0000049 tRNA binding 12/2751 80/18639 0.15 1.01630316248637 0.523934197414802 1 GO:0016776 phosphotransferase activity, phosphate group as acceptor 6/2751 39/18639 0.153846153846154 1.04236221793474 0.524622257084466 1 GO:0034212 protein N-acetyltransferase activity 8/2751 53/18639 0.150943396226415 1.02269500627559 0.531566552495623 1 GO:0005543 phospholipid binding 73/2751 497/18639 0.146881287726358 0.99517278150912 0.53797344195628 1 GO:0141108 transporter regulator activity 25/2751 170/18639 0.147058823529412 0.99637564949644 0.541195474399603 1 GO:0008381 mechanosensitive monoatomic ion channel activity 3/2751 19/18639 0.157894736842105 1.06979280261723 0.547003722150619 1 GO:0022821 solute:potassium antiporter activity 3/2751 19/18639 0.157894736842105 1.06979280261723 0.547003722150619 1 GO:0030506 ankyrin binding 3/2751 19/18639 0.157894736842105 1.06979280261723 0.547003722150619 1 GO:0042577 lipid phosphatase activity 3/2751 19/18639 0.157894736842105 1.06979280261723 0.547003722150619 1 GO:0070003 threonine-type peptidase activity 3/2751 19/18639 0.157894736842105 1.06979280261723 0.547003722150619 1 GO:0003995 acyl-CoA dehydrogenase activity 2/2751 12/18639 0.166666666666667 1.12922573609596 0.547169374414082 1 GO:0004126 cytidine deaminase activity 2/2751 12/18639 0.166666666666667 1.12922573609596 0.547169374414082 1 GO:0004859 phospholipase inhibitor activity 2/2751 12/18639 0.166666666666667 1.12922573609596 0.547169374414082 1 GO:0005095 GTPase inhibitor activity 2/2751 12/18639 0.166666666666667 1.12922573609596 0.547169374414082 1 GO:0005247 voltage-gated chloride channel activity 2/2751 12/18639 0.166666666666667 1.12922573609596 0.547169374414082 1 GO:0008179 adenylate cyclase binding 2/2751 12/18639 0.166666666666667 1.12922573609596 0.547169374414082 1 GO:0015368 calcium:monoatomic cation antiporter activity 2/2751 12/18639 0.166666666666667 1.12922573609596 0.547169374414082 1 GO:0016801 hydrolase activity, acting on ether bonds 2/2751 12/18639 0.166666666666667 1.12922573609596 0.547169374414082 1 GO:0016803 ether hydrolase activity 2/2751 12/18639 0.166666666666667 1.12922573609596 0.547169374414082 1 GO:0035251 UDP-glucosyltransferase activity 2/2751 12/18639 0.166666666666667 1.12922573609596 0.547169374414082 1 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 2/2751 12/18639 0.166666666666667 1.12922573609596 0.547169374414082 1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 4/2751 26/18639 0.153846153846154 1.04236221793474 0.547897439243169 1 GO:0016289 acyl-CoA hydrolase activity 4/2751 26/18639 0.153846153846154 1.04236221793474 0.547897439243169 1 GO:0030507 spectrin binding 4/2751 26/18639 0.153846153846154 1.04236221793474 0.547897439243169 1 GO:0051139 metal cation:proton antiporter activity 4/2751 26/18639 0.153846153846154 1.04236221793474 0.547897439243169 1 GO:0019239 deaminase activity 5/2751 33/18639 0.151515151515152 1.02656885099633 0.549227120931716 1 GO:0030296 protein tyrosine kinase activator activity 5/2751 33/18639 0.151515151515152 1.02656885099633 0.549227120931716 1 GO:0015036 disulfide oxidoreductase activity 6/2751 40/18639 0.15 1.01630316248637 0.550750139219965 1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 6/2751 40/18639 0.15 1.01630316248637 0.550750139219965 1 GO:0061791 GTPase motor activity 6/2751 40/18639 0.15 1.01630316248637 0.550750139219965 1 GO:1990606 membrane scission GTPase motor activity 6/2751 40/18639 0.15 1.01630316248637 0.550750139219965 1 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 8/2751 54/18639 0.148148148148148 1.00375620986308 0.553997333595162 1 GO:0140223 general transcription initiation factor activity 10/2751 68/18639 0.147058823529412 0.99637564949644 0.557271206196543 1 GO:0004222 metalloendopeptidase activity 16/2751 110/18639 0.145454545454545 0.985506096956479 0.566541527758611 1 GO:0001530 lipopolysaccharide binding 6/2751 41/18639 0.146341463414634 0.991515280474506 0.576203516490706 1 GO:0015020 glucuronosyltransferase activity 5/2751 34/18639 0.147058823529412 0.99637564949644 0.577179760177197 1 GO:0001671 ATPase activator activity 4/2751 27/18639 0.148148148148148 1.00375620986308 0.579261574726854 1 GO:0005385 zinc ion transmembrane transporter activity 4/2751 27/18639 0.148148148148148 1.00375620986308 0.579261574726854 1 GO:0016405 CoA-ligase activity 4/2751 27/18639 0.148148148148148 1.00375620986308 0.579261574726854 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/2751 27/18639 0.148148148148148 1.00375620986308 0.579261574726854 1 GO:0001664 G protein-coupled receptor binding 43/2751 297/18639 0.144781144781145 0.980943568729828 0.580111278073459 1 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 3/2751 20/18639 0.15 1.01630316248637 0.583431165177329 1 GO:0005326 neurotransmitter transmembrane transporter activity 3/2751 20/18639 0.15 1.01630316248637 0.583431165177329 1 GO:0015095 magnesium ion transmembrane transporter activity 3/2751 20/18639 0.15 1.01630316248637 0.583431165177329 1 GO:0016004 phospholipase activator activity 3/2751 20/18639 0.15 1.01630316248637 0.583431165177329 1 GO:0016408 C-acyltransferase activity 3/2751 20/18639 0.15 1.01630316248637 0.583431165177329 1 GO:0016505 peptidase activator activity involved in apoptotic process 3/2751 20/18639 0.15 1.01630316248637 0.583431165177329 1 GO:0030742 GTP-dependent protein binding 3/2751 20/18639 0.15 1.01630316248637 0.583431165177329 1 GO:0061608 nuclear import signal receptor activity 3/2751 20/18639 0.15 1.01630316248637 0.583431165177329 1 GO:0140664 ATP-dependent DNA damage sensor activity 3/2751 20/18639 0.15 1.01630316248637 0.583431165177329 1 GO:0003774 cytoskeletal motor activity 22/2751 153/18639 0.143790849673203 0.974233968396519 0.587970856624214 1 GO:0002161 aminoacyl-tRNA editing activity 2/2751 13/18639 0.153846153846154 1.04236221793474 0.592311941566419 1 GO:0004535 poly(A)-specific ribonuclease activity 2/2751 13/18639 0.153846153846154 1.04236221793474 0.592311941566419 1 GO:0005172 vascular endothelial growth factor receptor binding 2/2751 13/18639 0.153846153846154 1.04236221793474 0.592311941566419 1 GO:0008253 5'-nucleotidase activity 2/2751 13/18639 0.153846153846154 1.04236221793474 0.592311941566419 1 GO:0008417 fucosyltransferase activity 2/2751 13/18639 0.153846153846154 1.04236221793474 0.592311941566419 1 GO:0017154 semaphorin receptor activity 2/2751 13/18639 0.153846153846154 1.04236221793474 0.592311941566419 1 GO:0030955 potassium ion binding 2/2751 13/18639 0.153846153846154 1.04236221793474 0.592311941566419 1 GO:0046974 histone H3K9 methyltransferase activity 2/2751 13/18639 0.153846153846154 1.04236221793474 0.592311941566419 1 GO:0061459 L-arginine transmembrane transporter activity 2/2751 13/18639 0.153846153846154 1.04236221793474 0.592311941566419 1 GO:0140666 annealing activity 2/2751 13/18639 0.153846153846154 1.04236221793474 0.592311941566419 1 GO:0140852 histone ubiquitin ligase activity 2/2751 13/18639 0.153846153846154 1.04236221793474 0.592311941566419 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 13/2751 91/18639 0.142857142857143 0.967907773796542 0.59603619247035 1 GO:0016763 pentosyltransferase activity 7/2751 49/18639 0.142857142857143 0.967907773796542 0.598791630933143 1 GO:0004402 histone acetyltransferase activity 6/2751 42/18639 0.142857142857143 0.967907773796542 0.600913473333131 1 GO:0019894 kinesin binding 6/2751 42/18639 0.142857142857143 0.967907773796542 0.600913473333131 1 GO:0031492 nucleosomal DNA binding 6/2751 42/18639 0.142857142857143 0.967907773796542 0.600913473333131 1 GO:0051879 Hsp90 protein binding 6/2751 42/18639 0.142857142857143 0.967907773796542 0.600913473333131 1 GO:0010485 histone H4 acetyltransferase activity 5/2751 35/18639 0.142857142857143 0.967907773796542 0.604183667365227 1 GO:0061631 ubiquitin conjugating enzyme activity 5/2751 35/18639 0.142857142857143 0.967907773796542 0.604183667365227 1 GO:0036408 histone H3K14 acetyltransferase activity 4/2751 28/18639 0.142857142857143 0.967907773796542 0.609338461178055 1 GO:0051393 alpha-actinin binding 4/2751 28/18639 0.142857142857143 0.967907773796542 0.609338461178055 1 GO:0051959 dynein light intermediate chain binding 4/2751 28/18639 0.142857142857143 0.967907773796542 0.609338461178055 1 GO:0097718 disordered domain specific binding 4/2751 28/18639 0.142857142857143 0.967907773796542 0.609338461178055 1 GO:0019783 ubiquitin-like protein peptidase activity 18/2751 127/18639 0.141732283464567 0.960286452743025 0.612372651412969 1 GO:0004536 DNA nuclease activity 9/2751 64/18639 0.140625 0.952784214830971 0.616334628930205 1 GO:0005248 voltage-gated sodium channel activity 3/2751 21/18639 0.142857142857143 0.967907773796542 0.617932358598441 1 GO:0009975 cyclase activity 3/2751 21/18639 0.142857142857143 0.967907773796542 0.617932358598441 1 GO:0019200 carbohydrate kinase activity 3/2751 21/18639 0.142857142857143 0.967907773796542 0.617932358598441 1 GO:0035613 RNA stem-loop binding 3/2751 21/18639 0.142857142857143 0.967907773796542 0.617932358598441 1 GO:0015605 organophosphate ester transmembrane transporter activity 7/2751 50/18639 0.14 0.948549618320611 0.621047849717769 1 GO:0008375 acetylglucosaminyltransferase activity 6/2751 43/18639 0.13953488372093 0.945398290684994 0.624822435555137 1 GO:0020037 heme binding 20/2751 142/18639 0.140845070422535 0.954275269940252 0.626121556379073 1 GO:0015297 antiporter activity 19/2751 135/18639 0.140740740740741 0.953568399369926 0.626147708530177 1 GO:0050660 flavin adenine dinucleotide binding 12/2751 86/18639 0.13953488372093 0.945398290684994 0.629944271078506 1 GO:0004705 JUN kinase activity 2/2751 14/18639 0.142857142857143 0.967907773796542 0.633998611645921 1 GO:0005161 platelet-derived growth factor receptor binding 2/2751 14/18639 0.142857142857143 0.967907773796542 0.633998611645921 1 GO:0005347 ATP transmembrane transporter activity 2/2751 14/18639 0.142857142857143 0.967907773796542 0.633998611645921 1 GO:0005545 1-phosphatidylinositol binding 2/2751 14/18639 0.142857142857143 0.967907773796542 0.633998611645921 1 GO:0008494 translation activator activity 2/2751 14/18639 0.142857142857143 0.967907773796542 0.633998611645921 1 GO:0015386 potassium:proton antiporter activity 2/2751 14/18639 0.142857142857143 0.967907773796542 0.633998611645921 1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/2751 14/18639 0.142857142857143 0.967907773796542 0.633998611645921 1 GO:0019763 immunoglobulin receptor activity 2/2751 14/18639 0.142857142857143 0.967907773796542 0.633998611645921 1 GO:0019992 diacylglycerol binding 2/2751 14/18639 0.142857142857143 0.967907773796542 0.633998611645921 1 GO:0034236 protein kinase A catalytic subunit binding 2/2751 14/18639 0.142857142857143 0.967907773796542 0.633998611645921 1 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/2751 14/18639 0.142857142857143 0.967907773796542 0.633998611645921 1 GO:0046030 inositol trisphosphate phosphatase activity 2/2751 14/18639 0.142857142857143 0.967907773796542 0.633998611645921 1 GO:0061665 SUMO ligase activity 2/2751 14/18639 0.142857142857143 0.967907773796542 0.633998611645921 1 GO:0070742 C2H2 zinc finger domain binding 2/2751 14/18639 0.142857142857143 0.967907773796542 0.633998611645921 1 GO:1901612 cardiolipin binding 2/2751 14/18639 0.142857142857143 0.967907773796542 0.633998611645921 1 GO:1990825 sequence-specific mRNA binding 2/2751 14/18639 0.142857142857143 0.967907773796542 0.633998611645921 1 GO:0120013 lipid transfer activity 9/2751 65/18639 0.138461538461538 0.938125996141263 0.635589352071642 1 GO:0010484 histone H3 acetyltransferase activity 4/2751 29/18639 0.137931034482759 0.934531643665626 0.6380524740662 1 GO:0005496 steroid binding 15/2751 108/18639 0.138888888888889 0.941021446746638 0.642170378671848 1 GO:0001046 core promoter sequence-specific DNA binding 6/2751 44/18639 0.136363636363636 0.923911965896699 0.647883678617854 1 GO:0008970 phospholipase A1 activity 3/2751 22/18639 0.136363636363636 0.923911965896699 0.650436875255932 1 GO:0070034 telomerase RNA binding 3/2751 22/18639 0.136363636363636 0.923911965896699 0.650436875255932 1 GO:0019955 cytokine binding 20/2751 144/18639 0.138888888888889 0.941021446746638 0.651871108724932 1 GO:0042805 actinin binding 5/2751 37/18639 0.135135135135135 0.915588434672404 0.655092805795858 1 GO:0001786 phosphatidylserine binding 8/2751 59/18639 0.135593220338983 0.918692124281463 0.658322374480306 1 GO:0015459 potassium channel regulator activity 8/2751 59/18639 0.135593220338983 0.918692124281463 0.658322374480306 1 GO:0046906 tetrapyrrole binding 21/2751 152/18639 0.138157894736842 0.936068702290077 0.663591347949543 1 GO:0008106 alcohol dehydrogenase (NADP+) activity 4/2751 30/18639 0.133333333333333 0.903380588876772 0.665352150019772 1 GO:0043995 histone H4K5 acetyltransferase activity 4/2751 30/18639 0.133333333333333 0.903380588876772 0.665352150019772 1 GO:0043996 histone H4K8 acetyltransferase activity 4/2751 30/18639 0.133333333333333 0.903380588876772 0.665352150019772 1 GO:0043997 histone H4K12 acetyltransferase activity 4/2751 30/18639 0.133333333333333 0.903380588876772 0.665352150019772 1 GO:0004715 non-membrane spanning protein tyrosine kinase activity 6/2751 45/18639 0.133333333333333 0.903380588876772 0.670060733260251 1 GO:0008009 chemokine activity 6/2751 45/18639 0.133333333333333 0.903380588876772 0.670060733260251 1 GO:0004953 icosanoid receptor activity 2/2751 15/18639 0.133333333333333 0.903380588876772 0.672265812631157 1 GO:0008242 omega peptidase activity 2/2751 15/18639 0.133333333333333 0.903380588876772 0.672265812631157 1 GO:0008252 nucleotidase activity 2/2751 15/18639 0.133333333333333 0.903380588876772 0.672265812631157 1 GO:0015116 sulfate transmembrane transporter activity 2/2751 15/18639 0.133333333333333 0.903380588876772 0.672265812631157 1 GO:0031005 filamin binding 2/2751 15/18639 0.133333333333333 0.903380588876772 0.672265812631157 1 GO:0042809 nuclear vitamin D receptor binding 2/2751 15/18639 0.133333333333333 0.903380588876772 0.672265812631157 1 GO:0050700 CARD domain binding 2/2751 15/18639 0.133333333333333 0.903380588876772 0.672265812631157 1 GO:0051371 muscle alpha-actinin binding 2/2751 15/18639 0.133333333333333 0.903380588876772 0.672265812631157 1 GO:0099106 ion channel regulator activity 22/2751 160/18639 0.1375 0.931611232279171 0.674681782763164 1 GO:0030295 protein kinase activator activity 19/2751 139/18639 0.136690647482014 0.926127582121871 0.677925710759137 1 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 3/2751 23/18639 0.130434782608696 0.883741880422929 0.680914159046096 1 GO:0016251 RNA polymerase II general transcription initiation factor activity 7/2751 53/18639 0.132075471698113 0.894858130491142 0.683497491823624 1 GO:1901505 carbohydrate derivative transmembrane transporter activity 7/2751 53/18639 0.132075471698113 0.894858130491142 0.683497491823624 1 GO:0030145 manganese ion binding 9/2751 68/18639 0.132352941176471 0.896738084546796 0.690028926357548 1 GO:0032934 sterol binding 9/2751 68/18639 0.132352941176471 0.896738084546796 0.690028926357548 1 GO:1990841 promoter-specific chromatin binding 9/2751 68/18639 0.132352941176471 0.896738084546796 0.690028926357548 1 GO:0005164 tumor necrosis factor receptor binding 4/2751 31/18639 0.129032258064516 0.874239279558166 0.691207468532053 1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 6/2751 46/18639 0.130434782608696 0.883741880422929 0.691326714566358 1 GO:0030276 clathrin binding 6/2751 46/18639 0.130434782608696 0.883741880422929 0.691326714566358 1 GO:0004386 helicase activity 21/2751 155/18639 0.135483870967742 0.917951243536075 0.69897195894975 1 GO:0015485 cholesterol binding 7/2751 54/18639 0.12962962962963 0.878286683630195 0.702784749432119 1 GO:0042626 ATPase-coupled transmembrane transporter activity 13/2751 98/18639 0.13265306122449 0.898771504239646 0.70445730870688 1 GO:0008142 oxysterol binding 2/2751 16/18639 0.125 0.846919302071974 0.707214485751131 1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/2751 16/18639 0.125 0.846919302071974 0.707214485751131 1 GO:0016722 oxidoreductase activity, acting on metal ions 2/2751 16/18639 0.125 0.846919302071974 0.707214485751131 1 GO:0019841 retinol binding 2/2751 16/18639 0.125 0.846919302071974 0.707214485751131 1 GO:0030275 LRR domain binding 2/2751 16/18639 0.125 0.846919302071974 0.707214485751131 1 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/2751 16/18639 0.125 0.846919302071974 0.707214485751131 1 GO:0034450 ubiquitin-ubiquitin ligase activity 2/2751 16/18639 0.125 0.846919302071974 0.707214485751131 1 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/2751 16/18639 0.125 0.846919302071974 0.707214485751131 1 GO:0055102 lipase inhibitor activity 2/2751 16/18639 0.125 0.846919302071974 0.707214485751131 1 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/2751 16/18639 0.125 0.846919302071974 0.707214485751131 1 GO:0070411 I-SMAD binding 2/2751 16/18639 0.125 0.846919302071974 0.707214485751131 1 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 2/2751 16/18639 0.125 0.846919302071974 0.707214485751131 1 GO:0140327 flippase activity 2/2751 16/18639 0.125 0.846919302071974 0.707214485751131 1 GO:0015149 hexose transmembrane transporter activity 3/2751 24/18639 0.125 0.846919302071974 0.709366671480852 1 GO:0015295 solute:proton symporter activity 3/2751 24/18639 0.125 0.846919302071974 0.709366671480852 1 GO:0050431 transforming growth factor beta binding 3/2751 24/18639 0.125 0.846919302071974 0.709366671480852 1 GO:0050699 WW domain binding 3/2751 24/18639 0.125 0.846919302071974 0.709366671480852 1 GO:0055056 D-glucose transmembrane transporter activity 3/2751 24/18639 0.125 0.846919302071974 0.709366671480852 1 GO:0061733 protein-lysine-acetyltransferase activity 6/2751 47/18639 0.127659574468085 0.864938861690526 0.711663597841342 1 GO:0015106 bicarbonate transmembrane transporter activity 4/2751 32/18639 0.125 0.846919302071974 0.715607164927272 1 GO:0042910 xenobiotic transmembrane transporter activity 4/2751 32/18639 0.125 0.846919302071974 0.715607164927272 1 GO:0015631 tubulin binding 53/2751 385/18639 0.137662337662338 0.932711127476667 0.731618221749314 1 GO:0008483 transaminase activity 3/2751 25/18639 0.12 0.813042529989095 0.73582369381195 1 GO:0015645 fatty acid ligase activity 3/2751 25/18639 0.12 0.813042529989095 0.73582369381195 1 GO:0015662 P-type ion transporter activity 3/2751 25/18639 0.12 0.813042529989095 0.73582369381195 1 GO:0120515 fatty acid-CoA ligase activity 3/2751 25/18639 0.12 0.813042529989095 0.73582369381195 1 GO:0140358 P-type transmembrane transporter activity 3/2751 25/18639 0.12 0.813042529989095 0.73582369381195 1 GO:0030170 pyridoxal phosphate binding 7/2751 56/18639 0.125 0.846919302071974 0.738973251729635 1 GO:0170055 lipid transmembrane transporter activity 7/2751 56/18639 0.125 0.846919302071974 0.738973251729635 1 GO:0004550 nucleoside diphosphate kinase activity 2/2751 17/18639 0.117647058823529 0.797100519597152 0.738990260487401 1 GO:0005092 GDP-dissociation inhibitor activity 2/2751 17/18639 0.117647058823529 0.797100519597152 0.738990260487401 1 GO:0008429 phosphatidylethanolamine binding 2/2751 17/18639 0.117647058823529 0.797100519597152 0.738990260487401 1 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/2751 17/18639 0.117647058823529 0.797100519597152 0.738990260487401 1 GO:0016805 dipeptidase activity 2/2751 17/18639 0.117647058823529 0.797100519597152 0.738990260487401 1 GO:0017110 nucleoside diphosphate phosphatase activity 2/2751 17/18639 0.117647058823529 0.797100519597152 0.738990260487401 1 GO:0038191 neuropilin binding 2/2751 17/18639 0.117647058823529 0.797100519597152 0.738990260487401 1 GO:0045236 CXCR chemokine receptor binding 2/2751 17/18639 0.117647058823529 0.797100519597152 0.738990260487401 1 GO:0017080 sodium channel regulator activity 5/2751 41/18639 0.121951219512195 0.826262733728755 0.74355813315328 1 GO:0140828 metal cation:monoatomic cation antiporter activity 5/2751 41/18639 0.121951219512195 0.826262733728755 0.74355813315328 1 GO:0016410 N-acyltransferase activity 12/2751 94/18639 0.127659574468085 0.864938861690526 0.749780179880289 1 GO:0070279 vitamin B6 binding 7/2751 57/18639 0.12280701754386 0.83206106870229 0.755864260080158 1 GO:0016831 carboxy-lyase activity 4/2751 34/18639 0.117647058823529 0.797100519597152 0.760072986690955 1 GO:0005160 transforming growth factor beta receptor binding 3/2751 26/18639 0.115384615384615 0.781771663451053 0.760335813973095 1 GO:0008066 glutamate receptor activity 3/2751 26/18639 0.115384615384615 0.781771663451053 0.760335813973095 1 GO:0008198 ferrous iron binding 3/2751 26/18639 0.115384615384615 0.781771663451053 0.760335813973095 1 GO:0015145 monosaccharide transmembrane transporter activity 3/2751 26/18639 0.115384615384615 0.781771663451053 0.760335813973095 1 GO:0043548 phosphatidylinositol 3-kinase binding 3/2751 26/18639 0.115384615384615 0.781771663451053 0.760335813973095 1 GO:0019208 phosphatase regulator activity 15/2751 117/18639 0.128205128205128 0.868635181612281 0.760873027362822 1 GO:0048306 calcium-dependent protein binding 10/2751 80/18639 0.125 0.846919302071974 0.761498181904052 1 GO:0042056 chemoattractant activity 5/2751 42/18639 0.119047619047619 0.806589811497118 0.762834438534381 1 GO:0000400 four-way junction DNA binding 2/2751 18/18639 0.111111111111111 0.75281715739731 0.767768073123698 1 GO:0008525 phosphatidylcholine transporter activity 2/2751 18/18639 0.111111111111111 0.75281715739731 0.767768073123698 1 GO:0015172 acidic amino acid transmembrane transporter activity 2/2751 18/18639 0.111111111111111 0.75281715739731 0.767768073123698 1 GO:0016854 racemase and epimerase activity 2/2751 18/18639 0.111111111111111 0.75281715739731 0.767768073123698 1 GO:0008083 growth factor activity 21/2751 162/18639 0.12962962962963 0.878286683630195 0.772673566896486 1 GO:0019209 kinase activator activity 19/2751 148/18639 0.128378378378378 0.869809012938784 0.778563317904325 1 GO:0005245 voltage-gated calcium channel activity 5/2751 43/18639 0.116279069767442 0.787831908904162 0.780993912610597 1 GO:0005104 fibroblast growth factor receptor binding 3/2751 27/18639 0.111111111111111 0.75281715739731 0.782970093878875 1 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/2751 27/18639 0.111111111111111 0.75281715739731 0.782970093878875 1 GO:0005319 lipid transporter activity 23/2751 178/18639 0.129213483146067 0.875467143714849 0.785851216092907 1 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/2751 19/18639 0.105263157894737 0.71319520174482 0.793740349708766 1 GO:0008301 DNA binding, bending 2/2751 19/18639 0.105263157894737 0.71319520174482 0.793740349708766 1 GO:0008574 plus-end-directed microtubule motor activity 2/2751 19/18639 0.105263157894737 0.71319520174482 0.793740349708766 1 GO:0016918 retinal binding 2/2751 19/18639 0.105263157894737 0.71319520174482 0.793740349708766 1 GO:0022840 leak channel activity 2/2751 19/18639 0.105263157894737 0.71319520174482 0.793740349708766 1 GO:0022842 narrow pore channel activity 2/2751 19/18639 0.105263157894737 0.71319520174482 0.793740349708766 1 GO:0031420 alkali metal ion binding 2/2751 19/18639 0.105263157894737 0.71319520174482 0.793740349708766 1 GO:0046527 glucosyltransferase activity 2/2751 19/18639 0.105263157894737 0.71319520174482 0.793740349708766 1 GO:0097001 ceramide binding 2/2751 19/18639 0.105263157894737 0.71319520174482 0.793740349708766 1 GO:0120227 acyl-CoA binding 2/2751 19/18639 0.105263157894737 0.71319520174482 0.793740349708766 1 GO:1990380 K48-linked deubiquitinase activity 2/2751 19/18639 0.105263157894737 0.71319520174482 0.793740349708766 1 GO:0004857 enzyme inhibitor activity 56/2751 416/18639 0.134615384615385 0.912066940692895 0.793806416711699 1 GO:0004382 GDP phosphatase activity 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0004935 adrenergic receptor activity 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0005131 growth hormone receptor binding 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0008190 eukaryotic initiation factor 4E binding 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0016783 sulfurtransferase activity 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0016868 intramolecular phosphotransferase activity 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0019531 oxalate transmembrane transporter activity 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0019911 structural constituent of myelin sheath 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0031419 cobalamin binding 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0031434 mitogen-activated protein kinase kinase binding 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0032052 bile acid binding 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0035374 chondroitin sulfate binding 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0042166 acetylcholine binding 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0070739 protein-glutamic acid ligase activity 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0070740 tubulin-glutamic acid ligase activity 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0071723 lipopeptide binding 1/2751 10/18639 0.1 0.677535441657579 0.79756546173906 1 GO:0019842 vitamin binding 19/2751 150/18639 0.126666666666667 0.858211559432933 0.797704444267014 1 GO:0001223 transcription coactivator binding 5/2751 44/18639 0.113636363636364 0.769926638247249 0.798059327225052 1 GO:0004033 aldo-keto reductase (NADPH) activity 4/2751 36/18639 0.111111111111111 0.75281715739731 0.798939730028047 1 GO:0016757 glycosyltransferase activity 35/2751 267/18639 0.131086142322097 0.888155073333905 0.801672501233562 1 GO:0046625 sphingolipid binding 3/2751 28/18639 0.107142857142857 0.725930830347406 0.803805889802973 1 GO:0051119 sugar transmembrane transporter activity 3/2751 28/18639 0.107142857142857 0.725930830347406 0.803805889802973 1 GO:0005548 phospholipid transporter activity 8/2751 68/18639 0.117647058823529 0.797100519597152 0.804944454197242 1 GO:0002020 protease binding 17/2751 136/18639 0.125 0.846919302071974 0.805167700191736 1 GO:0035402 histone H3T11 kinase activity 32/2751 247/18639 0.129554655870445 0.877778709839779 0.813560687425229 1 GO:0035403 histone H3T6 kinase activity 32/2751 247/18639 0.129554655870445 0.877778709839779 0.813560687425229 1 GO:0005544 calcium-dependent phospholipid binding 6/2751 53/18639 0.113207547169811 0.767021254706693 0.814088737693014 1 GO:0019905 syntaxin binding 7/2751 61/18639 0.114754098360656 0.777499687148042 0.815509281093122 1 GO:0043394 proteoglycan binding 4/2751 37/18639 0.108108108108108 0.732470747737923 0.81637572084407 1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/2751 20/18639 0.1 0.677535441657579 0.817108036878926 1 GO:0042288 MHC class I protein binding 2/2751 20/18639 0.1 0.677535441657579 0.817108036878926 1 GO:0052745 inositol phosphate phosphatase activity 2/2751 20/18639 0.1 0.677535441657579 0.817108036878926 1 GO:0008080 N-acetyltransferase activity 8/2751 69/18639 0.115942028985507 0.785548338153715 0.817789321434433 1 GO:0004181 metallocarboxypeptidase activity 3/2751 29/18639 0.103448275862069 0.70089873274922 0.822931283926447 1 GO:0000099 sulfur amino acid transmembrane transporter activity 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0003953 NAD+ nucleosidase activity 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0005114 type II transforming growth factor beta receptor binding 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0008199 ferric iron binding 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0008503 benzodiazepine receptor activity 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0010854 adenylate cyclase regulator activity 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0019206 nucleoside kinase activity 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0032050 clathrin heavy chain binding 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0042608 T cell receptor binding 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0047676 arachidonate-CoA ligase activity 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0048185 activin binding 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0050786 RAGE receptor binding 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0140537 transcription regulator activator activity 1/2751 11/18639 0.0909090909090909 0.615941310597799 0.827459573862945 1 GO:0003925 G protein activity 6/2751 54/18639 0.111111111111111 0.75281715739731 0.828001736225626 1 GO:0070851 growth factor receptor binding 17/2751 139/18639 0.122302158273381 0.828640468214305 0.832156998830168 1 GO:0005506 iron ion binding 19/2751 154/18639 0.123376623376623 0.835920350097013 0.832434529452402 1 GO:0005501 retinoid binding 4/2751 38/18639 0.105263157894737 0.71319520174482 0.832548179327911 1 GO:0019840 isoprenoid binding 4/2751 38/18639 0.105263157894737 0.71319520174482 0.832548179327911 1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 31/2751 243/18639 0.127572016460905 0.864345625159875 0.835550289161009 1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/2751 21/18639 0.0952380952380952 0.645271849197694 0.838073897750556 1 GO:0005123 death receptor binding 2/2751 21/18639 0.0952380952380952 0.645271849197694 0.838073897750556 1 GO:0015125 bile acid transmembrane transporter activity 2/2751 21/18639 0.0952380952380952 0.645271849197694 0.838073897750556 1 GO:0015174 basic amino acid transmembrane transporter activity 2/2751 21/18639 0.0952380952380952 0.645271849197694 0.838073897750556 1 GO:0061891 calcium ion sensor activity 2/2751 21/18639 0.0952380952380952 0.645271849197694 0.838073897750556 1 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 29/2751 229/18639 0.126637554585153 0.858014314762873 0.839817134050741 1 GO:0015215 nucleotide transmembrane transporter activity 3/2751 30/18639 0.1 0.677535441657579 0.840440076582744 1 GO:0031210 phosphatidylcholine binding 3/2751 30/18639 0.1 0.677535441657579 0.840440076582744 1 GO:0051721 protein phosphatase 2A binding 3/2751 30/18639 0.1 0.677535441657579 0.840440076582744 1 GO:1901682 sulfur compound transmembrane transporter activity 7/2751 63/18639 0.111111111111111 0.75281715739731 0.840761126453906 1 GO:0004676 3-phosphoinositide-dependent protein kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:0004711 ribosomal protein S6 kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:0035175 histone H3S10 kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:0035979 histone H2AXS139 kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:0044022 histone H3S28 kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:0044023 histone H4S1 kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:0044024 histone H2AS1 kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:0044025 histone H2BS14 kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:0072354 histone H3T3 kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:0072371 histone H2AS121 kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:0072518 Rho-dependent protein serine/threonine kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:0140823 histone H2BS36 kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:0140855 histone H3S57 kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:0140995 histone H2A kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:0140997 histone H4 kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:0140998 histone H2B kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:1990244 histone H2AT120 kinase activity 31/2751 245/18639 0.126530612244898 0.857289742505508 0.848064266164298 1 GO:0004000 adenosine deaminase activity 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0004875 complement receptor activity 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0005025 transforming growth factor beta receptor activity, type I 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0005026 transforming growth factor beta receptor activity, type II 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0008603 cAMP-dependent protein kinase regulator activity 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0010853 cyclase activator activity 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0015132 prostaglandin transmembrane transporter activity 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0015269 calcium-activated potassium channel activity 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0016361 activin receptor activity, type I 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0016362 activin receptor activity, type II 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0017002 activin receptor activity 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0031543 peptidyl-proline dioxygenase activity 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0035197 siRNA binding 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0070410 co-SMAD binding 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0097677 STAT family protein binding 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0140900 chloride:bicarbonate antiporter activity 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/2751 12/18639 0.0833333333333333 0.564612868047982 0.852940501085569 1 GO:0019212 phosphatase inhibitor activity 6/2751 56/18639 0.107142857142857 0.725930830347406 0.853321378570355 1 GO:0004677 DNA-dependent protein kinase activity 31/2751 246/18639 0.126016260162602 0.853804824853047 0.854052427039747 1 GO:0140857 histone H3T45 kinase activity 31/2751 246/18639 0.126016260162602 0.853804824853047 0.854052427039747 1 GO:0004197 cysteine-type endopeptidase activity 10/2751 88/18639 0.113636363636364 0.769926638247249 0.854714166320651 1 GO:0140693 molecular condensate scaffold activity 5/2751 48/18639 0.104166666666667 0.705766085059978 0.856014209724621 1 GO:0008327 methyl-CpG binding 3/2751 31/18639 0.0967741935483871 0.655679459668625 0.856429284588175 1 GO:0016411 acylglycerol O-acyltransferase activity 3/2751 31/18639 0.0967741935483871 0.655679459668625 0.856429284588175 1 GO:0047499 calcium-independent phospholipase A2 activity 3/2751 31/18639 0.0967741935483871 0.655679459668625 0.856429284588175 1 GO:0072349 modified amino acid transmembrane transporter activity 3/2751 31/18639 0.0967741935483871 0.655679459668625 0.856429284588175 1 GO:0016407 acetyltransferase activity 11/2751 96/18639 0.114583333333333 0.776342693565976 0.856510667313226 1 GO:0050321 tau-protein kinase activity 2/2751 22/18639 0.0909090909090909 0.615941310597799 0.856837600000018 1 GO:0140035 ubiquitin-like protein reader activity 2/2751 22/18639 0.0909090909090909 0.615941310597799 0.856837600000018 1 GO:0140784 metal ion sensor activity 2/2751 22/18639 0.0909090909090909 0.615941310597799 0.856837600000018 1 GO:0071855 neuropeptide receptor binding 4/2751 40/18639 0.1 0.677535441657579 0.861332085373224 1 GO:0071949 FAD binding 4/2751 40/18639 0.1 0.677535441657579 0.861332085373224 1 GO:0140662 ATP-dependent protein folding chaperone 4/2751 40/18639 0.1 0.677535441657579 0.861332085373224 1 GO:0004679 AMP-activated protein kinase activity 31/2751 248/18639 0.125 0.846919302071974 0.865500209735872 1 GO:0001222 transcription corepressor binding 5/2751 49/18639 0.102040816326531 0.691362695568958 0.868116083858435 1 GO:0047498 calcium-dependent phospholipase A2 activity 3/2751 32/18639 0.09375 0.63518947655398 0.870997090070338 1 GO:0120015 sterol transfer activity 3/2751 32/18639 0.09375 0.63518947655398 0.870997090070338 1 GO:0016758 hexosyltransferase activity 24/2751 197/18639 0.121827411167513 0.825423888313802 0.871546460625579 1 GO:0035591 signaling adaptor activity 15/2751 129/18639 0.116279069767442 0.787831908904162 0.873109636270725 1 GO:0000295 adenine nucleotide transmembrane transporter activity 2/2751 23/18639 0.0869565217391304 0.589161253615286 0.873592213424201 1 GO:0005283 amino acid:sodium symporter activity 2/2751 23/18639 0.0869565217391304 0.589161253615286 0.873592213424201 1 GO:0016849 phosphorus-oxygen lyase activity 2/2751 23/18639 0.0869565217391304 0.589161253615286 0.873592213424201 1 GO:0042171 lysophosphatidic acid acyltransferase activity 2/2751 23/18639 0.0869565217391304 0.589161253615286 0.873592213424201 1 GO:0071617 lysophospholipid acyltransferase activity 2/2751 23/18639 0.0869565217391304 0.589161253615286 0.873592213424201 1 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/2751 23/18639 0.0869565217391304 0.589161253615286 0.873592213424201 1 GO:0001727 lipid kinase activity 4/2751 41/18639 0.0975609756097561 0.661010186983004 0.874064404532137 1 GO:0004465 lipoprotein lipase activity 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0009982 pseudouridine synthase activity 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0019855 calcium channel inhibitor activity 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0031432 titin binding 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0032396 inhibitory MHC class I receptor activity 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0045159 myosin II binding 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0046975 histone H3K36 methyltransferase activity 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0070123 transforming growth factor beta receptor activity, type III 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0071714 icosanoid transmembrane transporter activity 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0071837 HMG box domain binding 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0089720 caspase binding 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0140333 glycerophospholipid flippase activity 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/2751 13/18639 0.0769230769230769 0.521181108967369 0.874659547712165 1 GO:0000149 SNARE binding 12/2751 106/18639 0.113207547169811 0.767021254706693 0.875083823558472 1 GO:0017116 single-stranded DNA helicase activity 6/2751 58/18639 0.103448275862069 0.70089873274922 0.875498331199058 1 GO:0032813 tumor necrosis factor receptor superfamily binding 5/2751 50/18639 0.1 0.677535441657579 0.879347166991579 1 GO:0003725 double-stranded RNA binding 8/2751 75/18639 0.106666666666667 0.722704471101418 0.881562698127009 1 GO:0044183 protein folding chaperone 8/2751 75/18639 0.106666666666667 0.722704471101418 0.881562698127009 1 GO:0019888 protein phosphatase regulator activity 12/2751 107/18639 0.11214953271028 0.759852831765509 0.882738785108124 1 GO:0001221 transcription coregulator binding 13/2751 115/18639 0.11304347826087 0.765909629699872 0.883958676702125 1 GO:0101005 deubiquitinase activity 13/2751 115/18639 0.11304347826087 0.765909629699872 0.883958676702125 1 GO:0004520 DNA endonuclease activity 4/2751 42/18639 0.0952380952380952 0.645271849197694 0.885772822005585 1 GO:0004806 triacylglycerol lipase activity 2/2751 24/18639 0.0833333333333333 0.564612868047982 0.888521808146324 1 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/2751 24/18639 0.0833333333333333 0.564612868047982 0.888521808146324 1 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/2751 24/18639 0.0833333333333333 0.564612868047982 0.888521808146324 1 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/2751 24/18639 0.0833333333333333 0.564612868047982 0.888521808146324 1 GO:0003777 microtubule motor activity 7/2751 68/18639 0.102941176470588 0.697462954647508 0.891876680677512 1 GO:0005313 L-glutamate transmembrane transporter activity 1/2751 14/18639 0.0714285714285714 0.483953886898271 0.893171927409568 1 GO:0008331 high voltage-gated calcium channel activity 1/2751 14/18639 0.0714285714285714 0.483953886898271 0.893171927409568 1 GO:0008559 ABC-type xenobiotic transporter activity 1/2751 14/18639 0.0714285714285714 0.483953886898271 0.893171927409568 1 GO:0015926 glucosidase activity 1/2751 14/18639 0.0714285714285714 0.483953886898271 0.893171927409568 1 GO:0031404 chloride ion binding 1/2751 14/18639 0.0714285714285714 0.483953886898271 0.893171927409568 1 GO:0032454 histone H3K9 demethylase activity 1/2751 14/18639 0.0714285714285714 0.483953886898271 0.893171927409568 1 GO:0042043 neurexin family protein binding 1/2751 14/18639 0.0714285714285714 0.483953886898271 0.893171927409568 1 GO:0044548 S100 protein binding 1/2751 14/18639 0.0714285714285714 0.483953886898271 0.893171927409568 1 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/2751 14/18639 0.0714285714285714 0.483953886898271 0.893171927409568 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/2751 14/18639 0.0714285714285714 0.483953886898271 0.893171927409568 1 GO:0098821 BMP receptor activity 1/2751 14/18639 0.0714285714285714 0.483953886898271 0.893171927409568 1 GO:1901474 azole transmembrane transporter activity 1/2751 14/18639 0.0714285714285714 0.483953886898271 0.893171927409568 1 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 6/2751 60/18639 0.1 0.677535441657579 0.894791183596576 1 GO:0008376 acetylgalactosaminyltransferase activity 3/2751 34/18639 0.0882352941176471 0.597825389697864 0.896257462723033 1 GO:0004620 phospholipase activity 12/2751 109/18639 0.110091743119266 0.745910577971647 0.896908880702742 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 5/2751 52/18639 0.0961538461538462 0.651476386209211 0.899373512493424 1 GO:0008234 cysteine-type peptidase activity 22/2751 187/18639 0.117647058823529 0.797100519597152 0.899900553736273 1 GO:0004709 MAP kinase kinase kinase activity 2/2751 25/18639 0.08 0.542028353326063 0.901799905044965 1 GO:0120020 cholesterol transfer activity 2/2751 25/18639 0.08 0.542028353326063 0.901799905044965 1 GO:0042277 peptide binding 30/2751 249/18639 0.120481927710843 0.816307761033228 0.906739790681153 1 GO:0004623 phospholipase A2 activity 3/2751 35/18639 0.0857142857142857 0.580744664277925 0.907138999455971 1 GO:0005343 organic acid:sodium symporter activity 3/2751 35/18639 0.0857142857142857 0.580744664277925 0.907138999455971 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 7/2751 70/18639 0.1 0.677535441657579 0.90804899527725 1 GO:0004864 protein phosphatase inhibitor activity 5/2751 53/18639 0.0943396226415094 0.639184378922244 0.9082573432018 1 GO:0005246 calcium channel regulator activity 5/2751 53/18639 0.0943396226415094 0.639184378922244 0.9082573432018 1 GO:0004089 carbonate dehydratase activity 1/2751 15/18639 0.0666666666666667 0.451690294438386 0.908950935608026 1 GO:0004467 long-chain fatty acid-CoA ligase activity 1/2751 15/18639 0.0666666666666667 0.451690294438386 0.908950935608026 1 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/2751 15/18639 0.0666666666666667 0.451690294438386 0.908950935608026 1 GO:0010181 FMN binding 1/2751 15/18639 0.0666666666666667 0.451690294438386 0.908950935608026 1 GO:0030553 cGMP binding 1/2751 15/18639 0.0666666666666667 0.451690294438386 0.908950935608026 1 GO:0033130 acetylcholine receptor binding 1/2751 15/18639 0.0666666666666667 0.451690294438386 0.908950935608026 1 GO:0045504 dynein heavy chain binding 1/2751 15/18639 0.0666666666666667 0.451690294438386 0.908950935608026 1 GO:0048531 beta-1,3-galactosyltransferase activity 1/2751 15/18639 0.0666666666666667 0.451690294438386 0.908950935608026 1 GO:0120283 protein serine/threonine kinase binding 1/2751 15/18639 0.0666666666666667 0.451690294438386 0.908950935608026 1 GO:0140161 monocarboxylate:sodium symporter activity 1/2751 15/18639 0.0666666666666667 0.451690294438386 0.908950935608026 1 GO:0004435 phosphatidylinositol phospholipase C activity 2/2751 26/18639 0.0769230769230769 0.521181108967369 0.913588579300954 1 GO:0005112 Notch binding 2/2751 26/18639 0.0769230769230769 0.521181108967369 0.913588579300954 1 GO:0005227 calcium-activated cation channel activity 2/2751 26/18639 0.0769230769230769 0.521181108967369 0.913588579300954 1 GO:0015216 purine nucleotide transmembrane transporter activity 2/2751 26/18639 0.0769230769230769 0.521181108967369 0.913588579300954 1 GO:0019865 immunoglobulin binding 2/2751 26/18639 0.0769230769230769 0.521181108967369 0.913588579300954 1 GO:0052742 phosphatidylinositol kinase activity 2/2751 26/18639 0.0769230769230769 0.521181108967369 0.913588579300954 1 GO:0070412 R-SMAD binding 2/2751 26/18639 0.0769230769230769 0.521181108967369 0.913588579300954 1 GO:0140303 intramembrane lipid transporter activity 4/2751 45/18639 0.0888888888888889 0.602253725917848 0.915370867657642 1 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 5/2751 54/18639 0.0925925925925926 0.627347631164425 0.91644669085243 1 GO:0140463 chromatin-protein adaptor activity 5/2751 54/18639 0.0925925925925926 0.627347631164425 0.91644669085243 1 GO:0015108 chloride transmembrane transporter activity 13/2751 121/18639 0.107438016528926 0.727930639797399 0.920891378597396 1 GO:0000062 fatty-acyl-CoA binding 1/2751 16/18639 0.0625 0.423459651035987 0.922400032265152 1 GO:0005024 transforming growth factor beta receptor activity 1/2751 16/18639 0.0625 0.423459651035987 0.922400032265152 1 GO:0015385 sodium:proton antiporter activity 1/2751 16/18639 0.0625 0.423459651035987 0.922400032265152 1 GO:0022841 potassium ion leak channel activity 1/2751 16/18639 0.0625 0.423459651035987 0.922400032265152 1 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/2751 16/18639 0.0625 0.423459651035987 0.922400032265152 1 GO:0043023 ribosomal large subunit binding 1/2751 16/18639 0.0625 0.423459651035987 0.922400032265152 1 GO:0140328 floppase activity 1/2751 16/18639 0.0625 0.423459651035987 0.922400032265152 1 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/2751 27/18639 0.0740740740740741 0.50187810493154 0.92403805813472 1 GO:0008395 steroid hydroxylase activity 2/2751 27/18639 0.0740740740740741 0.50187810493154 0.92403805813472 1 GO:0023026 MHC class II protein complex binding 2/2751 27/18639 0.0740740740740741 0.50187810493154 0.92403805813472 1 GO:0008514 organic anion transmembrane transporter activity 32/2751 269/18639 0.118959107806691 0.805990116469983 0.925545749339511 1 GO:0022829 wide pore channel activity 3/2751 37/18639 0.0810810810810811 0.549353060803443 0.925851729838393 1 GO:0030280 structural constituent of skin epidermis 3/2751 37/18639 0.0810810810810811 0.549353060803443 0.925851729838393 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 5/2751 56/18639 0.0892857142857143 0.604942358622839 0.930912125877811 1 GO:0043495 protein-membrane adaptor activity 4/2751 47/18639 0.0851063829787234 0.576625907793684 0.931091426149785 1 GO:0061749 forked DNA-dependent helicase activity 4/2751 47/18639 0.0851063829787234 0.576625907793684 0.931091426149785 1 GO:0099095 ligand-gated monoatomic anion channel activity 4/2751 47/18639 0.0851063829787234 0.576625907793684 0.931091426149785 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 4/2751 47/18639 0.0851063829787234 0.576625907793684 0.931091426149785 1 GO:0005242 inward rectifier potassium channel activity 2/2751 28/18639 0.0714285714285714 0.483953886898271 0.933286686467931 1 GO:0016866 intramolecular transferase activity 2/2751 28/18639 0.0714285714285714 0.483953886898271 0.933286686467931 1 GO:0046966 nuclear thyroid hormone receptor binding 2/2751 28/18639 0.0714285714285714 0.483953886898271 0.933286686467931 1 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/2751 17/18639 0.0588235294117647 0.398550259798576 0.933863143001262 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/2751 17/18639 0.0588235294117647 0.398550259798576 0.933863143001262 1 GO:0030548 acetylcholine receptor regulator activity 1/2751 17/18639 0.0588235294117647 0.398550259798576 0.933863143001262 1 GO:0036041 long-chain fatty acid binding 1/2751 17/18639 0.0588235294117647 0.398550259798576 0.933863143001262 1 GO:1901567 fatty acid derivative binding 1/2751 17/18639 0.0588235294117647 0.398550259798576 0.933863143001262 1 GO:1990226 histone methyltransferase binding 1/2751 17/18639 0.0588235294117647 0.398550259798576 0.933863143001262 1 GO:0003678 DNA helicase activity 7/2751 74/18639 0.0945945945945946 0.640911904270683 0.934247708719175 1 GO:0004843 cysteine-type deubiquitinase activity 11/2751 108/18639 0.101851851851852 0.690082394280867 0.936668962876591 1 GO:0005254 chloride channel activity 8/2751 83/18639 0.0963855421686747 0.653046208826582 0.936780550967312 1 GO:0009378 four-way junction helicase activity 4/2751 48/18639 0.0833333333333333 0.564612868047982 0.937916627642982 1 GO:0036121 double-stranded DNA helicase activity 4/2751 48/18639 0.0833333333333333 0.564612868047982 0.937916627642982 1 GO:0043138 3'-5' DNA helicase activity 4/2751 48/18639 0.0833333333333333 0.564612868047982 0.937916627642982 1 GO:0005261 monoatomic cation channel activity 41/2751 341/18639 0.120234604105572 0.814632055951928 0.938239887811101 1 GO:0043177 organic acid binding 21/2751 189/18639 0.111111111111111 0.75281715739731 0.94080185918106 1 GO:0004629 phospholipase C activity 2/2751 29/18639 0.0689655172413793 0.467265821832813 0.941461160730264 1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 2/2751 29/18639 0.0689655172413793 0.467265821832813 0.941461160730264 1 GO:0005416 amino acid:monoatomic cation symporter activity 2/2751 29/18639 0.0689655172413793 0.467265821832813 0.941461160730264 1 GO:0035250 UDP-galactosyltransferase activity 2/2751 29/18639 0.0689655172413793 0.467265821832813 0.941461160730264 1 GO:0051861 glycolipid binding 2/2751 29/18639 0.0689655172413793 0.467265821832813 0.941461160730264 1 GO:0097472 cyclin-dependent protein kinase activity 2/2751 29/18639 0.0689655172413793 0.467265821832813 0.941461160730264 1 GO:0106222 lncRNA binding 2/2751 29/18639 0.0689655172413793 0.467265821832813 0.941461160730264 1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/2751 18/18639 0.0555555555555556 0.376408578698655 0.943633441229354 1 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/2751 18/18639 0.0555555555555556 0.376408578698655 0.943633441229354 1 GO:0008409 5'-3' exonuclease activity 1/2751 18/18639 0.0555555555555556 0.376408578698655 0.943633441229354 1 GO:0015280 ligand-gated sodium channel activity 1/2751 18/18639 0.0555555555555556 0.376408578698655 0.943633441229354 1 GO:0017128 phospholipid scramblase activity 1/2751 18/18639 0.0555555555555556 0.376408578698655 0.943633441229354 1 GO:0022851 GABA-gated chloride ion channel activity 1/2751 18/18639 0.0555555555555556 0.376408578698655 0.943633441229354 1 GO:0032393 MHC class I receptor activity 1/2751 18/18639 0.0555555555555556 0.376408578698655 0.943633441229354 1 GO:0034185 apolipoprotein binding 1/2751 18/18639 0.0555555555555556 0.376408578698655 0.943633441229354 1 GO:0099602 neurotransmitter receptor regulator activity 1/2751 18/18639 0.0555555555555556 0.376408578698655 0.943633441229354 1 GO:0008017 microtubule binding 32/2751 276/18639 0.115942028985507 0.785548338153715 0.946582674244265 1 GO:0015144 carbohydrate transmembrane transporter activity 3/2751 40/18639 0.075 0.508151581243184 0.947506904891644 1 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/2751 40/18639 0.075 0.508151581243184 0.947506904891644 1 GO:0050997 quaternary ammonium group binding 3/2751 40/18639 0.075 0.508151581243184 0.947506904891644 1 GO:0022839 monoatomic ion-gated channel activity 2/2751 30/18639 0.0666666666666667 0.451690294438386 0.948676952455086 1 GO:0048020 CCR chemokine receptor binding 4/2751 50/18639 0.08 0.542028353326063 0.949753638113592 1 GO:0106310 protein serine kinase activity 43/2751 361/18639 0.119113573407202 0.807036675658612 0.950149461037679 1 GO:0005253 monoatomic anion channel activity 10/2751 103/18639 0.0970873786407767 0.657801399667552 0.950650115766439 1 GO:0004890 GABA-A receptor activity 1/2751 19/18639 0.0526315789473684 0.35659760087241 0.95196083520272 1 GO:0005229 intracellularly calcium-gated chloride channel activity 1/2751 19/18639 0.0526315789473684 0.35659760087241 0.95196083520272 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/2751 19/18639 0.0526315789473684 0.35659760087241 0.95196083520272 1 GO:0034987 immunoglobulin receptor binding 1/2751 19/18639 0.0526315789473684 0.35659760087241 0.95196083520272 1 GO:0043395 heparan sulfate proteoglycan binding 1/2751 19/18639 0.0526315789473684 0.35659760087241 0.95196083520272 1 GO:0140036 ubiquitin-modified protein reader activity 1/2751 19/18639 0.0526315789473684 0.35659760087241 0.95196083520272 1 GO:0141147 intracellularly calcium-gated channel activity 1/2751 19/18639 0.0526315789473684 0.35659760087241 0.95196083520272 1 GO:0004812 aminoacyl-tRNA ligase activity 3/2751 41/18639 0.0731707317073171 0.495757640237253 0.95330499702529 1 GO:0008227 G protein-coupled amine receptor activity 3/2751 41/18639 0.0731707317073171 0.495757640237253 0.95330499702529 1 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/2751 41/18639 0.0731707317073171 0.495757640237253 0.95330499702529 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 3/2751 41/18639 0.0731707317073171 0.495757640237253 0.95330499702529 1 GO:0005272 sodium channel activity 4/2751 51/18639 0.0784313725490196 0.531400346398101 0.954860201091307 1 GO:0016597 amino acid binding 4/2751 51/18639 0.0784313725490196 0.531400346398101 0.954860201091307 1 GO:0005184 neuropeptide hormone activity 2/2751 31/18639 0.0645161290322581 0.437119639779083 0.955038860583839 1 GO:0005452 solute:inorganic anion antiporter activity 2/2751 31/18639 0.0645161290322581 0.437119639779083 0.955038860583839 1 GO:0031406 carboxylic acid binding 20/2751 187/18639 0.106951871657754 0.724636835997411 0.95820726754554 1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 12/2751 122/18639 0.0983606557377049 0.66642830326975 0.958392966867736 1 GO:0004674 protein serine/threonine kinase activity 52/2751 433/18639 0.120092378752887 0.813668428780464 0.958505816605121 1 GO:0005216 monoatomic ion channel activity 54/2751 448/18639 0.120535714285714 0.816672184140832 0.958523637258217 1 GO:0001614 purinergic nucleotide receptor activity 1/2751 20/18639 0.05 0.33876772082879 0.959058350903972 1 GO:0001972 retinoic acid binding 1/2751 20/18639 0.05 0.33876772082879 0.959058350903972 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/2751 20/18639 0.05 0.33876772082879 0.959058350903972 1 GO:0010851 cyclase regulator activity 1/2751 20/18639 0.05 0.33876772082879 0.959058350903972 1 GO:0015464 acetylcholine receptor activity 1/2751 20/18639 0.05 0.33876772082879 0.959058350903972 1 GO:0016502 nucleotide receptor activity 1/2751 20/18639 0.05 0.33876772082879 0.959058350903972 1 GO:0030627 pre-mRNA 5'-splice site binding 1/2751 20/18639 0.05 0.33876772082879 0.959058350903972 1 GO:0140767 enzyme-substrate adaptor activity 14/2751 139/18639 0.100719424460432 0.682409797352957 0.959673974935495 1 GO:0008378 galactosyltransferase activity 2/2751 32/18639 0.0625 0.423459651035987 0.960641645284739 1 GO:0160041 neuropeptide activity 2/2751 32/18639 0.0625 0.423459651035987 0.960641645284739 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 4/2751 53/18639 0.0754716981132075 0.511347503137796 0.963665867204206 1 GO:0042379 chemokine receptor binding 6/2751 72/18639 0.0833333333333333 0.564612868047982 0.964702600336015 1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/2751 21/18639 0.0476190476190476 0.322635924598847 0.965107573561643 1 GO:0036122 BMP binding 1/2751 21/18639 0.0476190476190476 0.322635924598847 0.965107573561643 1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/2751 21/18639 0.0476190476190476 0.322635924598847 0.965107573561643 1 GO:0051010 microtubule plus-end binding 1/2751 21/18639 0.0476190476190476 0.322635924598847 0.965107573561643 1 GO:0051428 peptide hormone receptor binding 1/2751 21/18639 0.0476190476190476 0.322635924598847 0.965107573561643 1 GO:0022824 transmitter-gated monoatomic ion channel activity 5/2751 63/18639 0.0793650793650794 0.537726540998079 0.965520816173046 1 GO:0022835 transmitter-gated channel activity 5/2751 63/18639 0.0793650793650794 0.537726540998079 0.965520816173046 1 GO:0051427 hormone receptor binding 2/2751 34/18639 0.0588235294117647 0.398550259798576 0.969902784991608 1 GO:0005243 gap junction channel activity 1/2751 22/18639 0.0454545454545455 0.3079706552989 0.970263286588387 1 GO:0015377 chloride:monoatomic cation symporter activity 1/2751 22/18639 0.0454545454545455 0.3079706552989 0.970263286588387 1 GO:0033691 sialic acid binding 1/2751 22/18639 0.0454545454545455 0.3079706552989 0.970263286588387 1 GO:0035064 methylated histone binding 6/2751 74/18639 0.0810810810810811 0.549353060803443 0.97092766452923 1 GO:0061134 peptidase regulator activity 24/2751 226/18639 0.106194690265487 0.719506663707164 0.972753903473767 1 GO:0051213 dioxygenase activity 8/2751 93/18639 0.0860215053763441 0.582826186372111 0.9732063146511 1 GO:0140566 histone reader activity 2/2751 35/18639 0.0571428571428571 0.387163109518617 0.973706650781647 1 GO:0008194 UDP-glycosyltransferase activity 14/2751 145/18639 0.096551724137931 0.654172150565938 0.973822352149723 1 GO:0004180 carboxypeptidase activity 3/2751 46/18639 0.0652173913043478 0.441870940211465 0.974320872951379 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/2751 23/18639 0.0434782608695652 0.294580626807643 0.974657426277668 1 GO:0005212 structural constituent of eye lens 1/2751 23/18639 0.0434782608695652 0.294580626807643 0.974657426277668 1 GO:0016917 GABA receptor activity 1/2751 23/18639 0.0434782608695652 0.294580626807643 0.974657426277668 1 GO:0042562 hormone binding 8/2751 94/18639 0.0851063829787234 0.576625907793684 0.975508675258352 1 GO:0140034 methylation-dependent protein binding 6/2751 76/18639 0.0789473684210526 0.534896401308615 0.976127114659932 1 GO:0004190 aspartic-type endopeptidase activity 2/2751 36/18639 0.0555555555555556 0.376408578698655 0.977043789258409 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 2/2751 36/18639 0.0555555555555556 0.376408578698655 0.977043789258409 1 GO:0005504 fatty acid binding 3/2751 47/18639 0.0638297872340425 0.432469430845263 0.977268335233306 1 GO:0016298 lipase activity 12/2751 130/18639 0.0923076923076923 0.625417330760842 0.97746444733801 1 GO:0005315 phosphate transmembrane transporter activity 1/2751 24/18639 0.0416666666666667 0.282306434023991 0.978402453152944 1 GO:0030552 cAMP binding 1/2751 24/18639 0.0416666666666667 0.282306434023991 0.978402453152944 1 GO:0070300 phosphatidic acid binding 1/2751 24/18639 0.0416666666666667 0.282306434023991 0.978402453152944 1 GO:0004896 cytokine receptor activity 8/2751 96/18639 0.0833333333333333 0.564612868047982 0.979578136311597 1 GO:0023023 MHC protein complex binding 2/2751 37/18639 0.0540540540540541 0.366235373868962 0.979969049796695 1 GO:0030551 cyclic nucleotide binding 2/2751 37/18639 0.0540540540540541 0.366235373868962 0.979969049796695 1 GO:0070001 aspartic-type peptidase activity 2/2751 37/18639 0.0540540540540541 0.366235373868962 0.979969049796695 1 GO:0008509 monoatomic anion transmembrane transporter activity 14/2751 149/18639 0.0939597315436242 0.63661048209437 0.980590744041963 1 GO:0004175 endopeptidase activity 46/2751 405/18639 0.11358024691358 0.769546427561695 0.981151021945406 1 GO:0005251 delayed rectifier potassium channel activity 1/2751 25/18639 0.04 0.271014176663032 0.981594225990776 1 GO:0015271 outward rectifier potassium channel activity 1/2751 25/18639 0.04 0.271014176663032 0.981594225990776 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/2751 25/18639 0.04 0.271014176663032 0.981594225990776 1 GO:0098960 postsynaptic neurotransmitter receptor activity 5/2751 69/18639 0.072463768115942 0.490967711346072 0.981596699649895 1 GO:0005126 cytokine receptor binding 29/2751 275/18639 0.105454545454545 0.714491920293447 0.984080011113853 1 GO:0032451 demethylase activity 2/2751 40/18639 0.05 0.33876772082879 0.986735248141433 1 GO:0046943 carboxylic acid transmembrane transporter activity 18/2751 188/18639 0.0957446808510638 0.648704146267895 0.986805177411033 1 GO:0015179 L-amino acid transmembrane transporter activity 4/2751 62/18639 0.0645161290322581 0.437119639779083 0.986837409577615 1 GO:0031490 chromatin DNA binding 11/2751 128/18639 0.0859375 0.582257020174482 0.987026740309394 1 GO:0005342 organic acid transmembrane transporter activity 18/2751 189/18639 0.0952380952380952 0.645271849197694 0.987721472224893 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 5/2751 73/18639 0.0684931506849315 0.464065370998342 0.988061487709337 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 17/2751 181/18639 0.0939226519337017 0.636359254595516 0.988112352762921 1 GO:0015171 amino acid transmembrane transporter activity 8/2751 102/18639 0.0784313725490196 0.531400346398101 0.988340344808898 1 GO:0042287 MHC protein binding 2/2751 41/18639 0.0487804878048781 0.330505093491502 0.988449619993543 1 GO:0008527 taste receptor activity 1/2751 28/18639 0.0357142857142857 0.241976943449135 0.9886085557393 1 GO:0141052 histone H3 demethylase activity 1/2751 28/18639 0.0357142857142857 0.241976943449135 0.9886085557393 1 GO:0017046 peptide hormone binding 3/2751 53/18639 0.0566037735849057 0.383510627353347 0.98921508442907 1 GO:0005179 hormone activity 11/2751 132/18639 0.0833333333333333 0.564612868047982 0.990815176666581 1 GO:0004252 serine-type endopeptidase activity 16/2751 176/18639 0.0909090909090909 0.615941310597799 0.99089740276288 1 GO:0008236 serine-type peptidase activity 18/2751 194/18639 0.0927835051546392 0.628641131434867 0.991488352283208 1 GO:0008374 O-acyltransferase activity 3/2751 55/18639 0.0545454545454545 0.369564786358679 0.991629068962389 1 GO:0001965 G-protein alpha-subunit binding 1/2751 30/18639 0.0333333333333333 0.225845147219193 0.99172740640707 1 GO:0032452 histone demethylase activity 1/2751 30/18639 0.0333333333333333 0.225845147219193 0.99172740640707 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 54/2751 484/18639 0.111570247933884 0.755927972097299 0.99185010975292 1 GO:0015291 secondary active transmembrane transporter activity 29/2751 287/18639 0.101045296167247 0.684617693660968 0.992351971176719 1 GO:0015294 solute:monoatomic cation symporter activity 9/2751 116/18639 0.0775862068965517 0.525674049561915 0.992533512591662 1 GO:0140457 protein demethylase activity 1/2751 31/18639 0.032258064516129 0.218559819889542 0.992950357934511 1 GO:0046873 metal ion transmembrane transporter activity 49/2751 450/18639 0.108888888888889 0.737760814249364 0.993688946669991 1 GO:0017171 serine hydrolase activity 18/2751 198/18639 0.0909090909090909 0.615941310597799 0.993699310436609 1 GO:0033293 monocarboxylic acid binding 5/2751 79/18639 0.0632911392405063 0.428819899783278 0.993878010184223 1 GO:0001216 DNA-binding transcription activator activity 54/2751 491/18639 0.109979633401222 0.745150994898356 0.994266969111188 1 GO:0061980 regulatory RNA binding 3/2751 58/18639 0.0517241379310345 0.35044936637461 0.994298887066559 1 GO:0005125 cytokine activity 22/2751 234/18639 0.094017094017094 0.636999133182339 0.994541621629916 1 GO:0015103 inorganic anion transmembrane transporter activity 14/2751 165/18639 0.0848484848484849 0.574878556557946 0.99458979168587 1 GO:0019956 chemokine binding 1/2751 33/18639 0.0303030303030303 0.205313770199266 0.994880757823491 1 GO:0015101 organic cation transmembrane transporter activity 5/2751 81/18639 0.0617283950617284 0.418231754109617 0.995122162801191 1 GO:0061135 endopeptidase regulator activity 16/2751 184/18639 0.0869565217391304 0.589161253615286 0.995155341273589 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/2751 34/18639 0.0294117647058824 0.199275129899288 0.995637666091124 1 GO:0015276 ligand-gated monoatomic ion channel activity 16/2751 186/18639 0.0860215053763441 0.582826186372111 0.995879574968105 1 GO:0022834 ligand-gated channel activity 16/2751 188/18639 0.0851063829787234 0.576625907793684 0.996501276759172 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 1/2751 36/18639 0.0277777777777778 0.188204289349328 0.996832379001589 1 GO:0005244 voltage-gated monoatomic ion channel activity 14/2751 173/18639 0.0809248554913295 0.548294577063937 0.997266426797186 1 GO:0099094 ligand-gated monoatomic cation channel activity 10/2751 136/18639 0.0735294117647059 0.49818782474822 0.997284331724517 1 GO:0030594 neurotransmitter receptor activity 6/2751 97/18639 0.0618556701030928 0.419094087623245 0.997413724265763 1 GO:0140375 immune receptor activity 12/2751 156/18639 0.0769230769230769 0.521181108967369 0.997577731325253 1 GO:0022832 voltage-gated channel activity 14/2751 175/18639 0.08 0.542028353326063 0.997704939799232 1 GO:0015370 solute:sodium symporter activity 4/2751 79/18639 0.0506329113924051 0.343055919826622 0.998309525788343 1 GO:0015079 potassium ion transmembrane transporter activity 12/2751 160/18639 0.075 0.508151581243184 0.998328259893091 1 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 24/2751 268/18639 0.0895522388059701 0.60674815670828 0.998425758937071 1 GO:0001217 DNA-binding transcription repressor activity 25/2751 278/18639 0.0899280575539568 0.609294461922283 0.998581351087061 1 GO:0035198 miRNA binding 1/2751 42/18639 0.0238095238095238 0.161317962299424 0.998787507964739 1 GO:0015293 symporter activity 10/2751 146/18639 0.0684931506849315 0.464065370998342 0.998987588280586 1 GO:0004497 monooxygenase activity 6/2751 106/18639 0.0566037735849057 0.383510627353347 0.999069432157412 1 GO:0042605 peptide antigen binding 1/2751 45/18639 0.0222222222222222 0.150563431479462 0.999249938261768 1 GO:0030414 peptidase inhibitor activity 12/2751 169/18639 0.0710059171597633 0.481090254431417 0.999290910177256 1 GO:0003730 mRNA 3'-UTR binding 22/2751 262/18639 0.083969465648855 0.568922889941479 0.999357806748357 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/2751 46/18639 0.0217391304347826 0.147290313403822 0.999360910609938 1 GO:0022836 gated channel activity 28/2751 318/18639 0.0880503144654088 0.596572086994095 0.999508052528647 1 GO:0022843 voltage-gated monoatomic cation channel activity 9/2751 143/18639 0.0629370629370629 0.426420907336938 0.999508176226457 1 GO:0015081 sodium ion transmembrane transporter activity 11/2751 164/18639 0.0670731707317073 0.454444503550815 0.999556322426713 1 GO:0005267 potassium channel activity 7/2751 124/18639 0.0564516129032258 0.382479684806698 0.999597177905422 1 GO:0004866 endopeptidase inhibitor activity 10/2751 161/18639 0.062111801242236 0.420829466868061 0.999785764675397 1 GO:0005249 voltage-gated potassium channel activity 4/2751 98/18639 0.0408163265306122 0.276545078227583 0.999852483265364 1 GO:0004867 serine-type endopeptidase inhibitor activity 3/2751 95/18639 0.0315789473684211 0.213958560523446 0.999962164200969 1 GO:0008528 G protein-coupled peptide receptor activity 5/2751 122/18639 0.040983606557377 0.277678459695729 0.99996793591213 1 GO:0001653 peptide receptor activity 5/2751 128/18639 0.0390625 0.264662281897492 0.999985292057315 1 GO:0003823 antigen binding 3/2751 174/18639 0.0172413793103448 0.116816455458203 0.99999999963375 1 GO:0045182 translation regulator activity 11/2751 356/18639 0.0308988764044944 0.20935083871442 0.999999999999968 1 GO:0030371 translation repressor activity 4/2751 329/18639 0.0121580547112462 0.082375129684812 1 1