category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	93/526	238/9376	6.9652682365722	F13A1/RPS23/C1QA/RPL27A/RPS15/CCL2/RPS18/RPL30/C1QB/RPLP1/C1QC/RPL19/RPS11/RPL26/RPS12/RPL23/RPS27A/RPS2/RPS4X/RPL10/RPL28/RPL32/RPS14/RPL15/RPL14/RPS24/CYBB/RPS15A/CFD/FAU/RPL13/RPL21/RPL13A/RPL3/RPL39/RPS9/RPL7A/RPL41/RPL34/RPS7/RPL23A/RPL36A/RPL27/RPL11/RPL35/RPL29/RPL38/NRP1/RPS19/RPS8/RPL9/RPL24/RPL10A/RPS16/RPS20/UBA52/RPS3A/RPS13/RPL37/RPS25/RPL8/RPLP2/RPL22/RPL18/RPL36/RPL37A/RPL35A/RPL17/RPL12/RPL7/RPL18A/RPS6/RPS5/RPL31/RPS28/RPL5/RPL6/JUN/FCGR2A/RPS17/RPL36AL/C3AR1/RPS21/C2/RPS10/SYK/TLR4/RPL22L1/PRKCB/NLRP3/TNFRSF1A/CASP1/TLR7	22.7247834646803
Genetic Information Processing	Translation	hsa03010	Ribosome	79/526	222/9376	6.3431644572329	RPS23/RPL27A/RPS15/RPS18/RPL30/RPLP1/RPL19/RPS11/RPL26/RPS12/RPL23/RPS27A/RPS2/RPS4X/RPL10/RPL28/RPL32/RPS14/RPL15/RPL14/RPS24/RPS15A/FAU/RPL13/RPL21/RPL13A/RPL3/RPL39/RPS9/RPL7A/RPL41/RPL34/RPS7/RPL23A/RPL36A/RPL27/RPL11/RPL35/RPL29/RPL38/RPS19/RPS8/RPL9/RPL24/RPL10A/RPS16/RPS20/UBA52/RPS3A/RPS13/RPL37/RPS25/RPL8/RPLP2/RPL22/RPL18/RPL36/RPL37A/RACK1/RPL35A/RPL17/RPL12/RPL7/RPL18A/RPS6/RPS5/RPL31/RPS28/RPL5/RPL6/RPS17/RPL36AL/RPS21/RPS10/MRPS21/MRPL14/MRPL54/RPL22L1/MRPL20	19.6415813318025
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	58/526	138/9376	7.4917066181738	ATP5F1E/MT-ATP6/MT-CYB/MT-CO2/UQCRB/NDUFA4/ATP5MG/COX6C/UQCR10/UQCR11/COX6B1/MT-ND1/COX8A/COX7C/NDUFC2/COX7B/NDUFA1/NDUFA13/COX4I1/ATP5MC3/NDUFB11/NDUFA2/ATP6V0C/NDUFB2/MT-CO3/COX6A1/ATP5MF/ATP5MC2/COX5B/NDUFS6/ATP6V0B/UQCRQ/NDUFS5/COX7A2/NDUFB8/NDUFC1/ATP6V1F/NDUFB10/UQCRH/NDUFB4/ATP5PF/NDUFA3/NDUFA11/NDUFS7/NDUFB7/ATP5PD/NDUFB3/NDUFV2/ATP5PO/NDUFS3/ATP5F1D/ATP5ME/NDUFA6/NDUFB1/NDUFS8/NDUFA12/ATP5MC1/COX7A2L	18.7290747750892
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	64/526	205/9376	5.56490772512288	CD36/COL3A1/CYBA/ATP5F1E/MT-ATP6/CYBB/COL1A1/MT-CYB/MT-CO2/UQCRB/NDUFA4/COX6C/UQCR10/UQCR11/COX6B1/MT-ND1/COX8A/COX7C/NCF4/NDUFC2/COX7B/NDUFA1/NDUFA13/COX4I1/ATP5MC3/NDUFB11/COL1A2/NDUFA2/NDUFB2/MT-CO3/COX6A1/ATP5MC2/COX5B/SLC25A6/NDUFS6/UQCRQ/NDUFS5/COX7A2/NDUFB8/NDUFC1/RYR2/NDUFB10/UQCRH/NDUFB4/SLC25A5/ATP5PF/NDUFA3/NDUFA11/NDUFS7/NDUFB7/ATP5PD/NDUFB3/NDUFV2/PRKCB/ATP5PO/NDUFS3/ATP5F1D/NDUFA6/NDUFB1/NDUFS8/NDUFA12/ATP5MC1/COX7A2L/MPC1	16.1104422284046
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	72/526	275/9376	4.66693397856896	C1QA/CYBA/C1QB/C1QC/ATP5F1E/MT-ATP6/CYBB/MT-CYB/MT-CO2/TUBA1B/UQCRB/NDUFA4/COX6C/UQCR10/UQCR11/COX6B1/MT-ND1/COX8A/COX7C/NCF4/NDUFC2/COX7B/NDUFA1/NDUFA13/COX4I1/ATP5MC3/NDUFB11/PSMA7/EGR1/NDUFA2/NDUFB2/MT-CO3/COX6A1/ITPR2/ATP5MC2/COX5B/SLC25A6/NDUFS6/UQCRQ/NDUFS5/COX7A2/NDUFB8/NDUFC1/RYR2/NDUFB10/UQCRH/NDUFB4/SLC25A5/ATP5PF/NDUFA3/SOD1/NDUFA11/NDUFS7/NDUFB7/ATP5PD/NDUFB3/TUBB/NDUFV2/PSMB6/ATP5PO/NDUFS3/PSMB1/HSPA8/ATP5F1D/NDUFA6/NDUFB1/PSMD8/NDUFS8/PSMB5/NDUFA12/ATP5MC1/COX7A2L	15.0463706313705
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	71/526	268/9376	4.72231995913966	RPS27A/ATP5F1E/MT-ATP6/UBB/MT-CYB/MT-CO2/TUBA1B/UQCRB/NDUFA4/UBA52/COX6C/UQCR10/CALM2/UQCR11/COX6B1/MT-ND1/COX8A/COX7C/NDUFC2/COX7B/GNAI2/NDUFA1/NDUFA13/COX4I1/ATP5MC3/NDUFB11/PSMA7/SNCA/NDUFA2/NDUFB2/MT-CO3/COX6A1/ITPR2/ATP5MC2/COX5B/SLC25A6/NDUFS6/CALM3/UQCRQ/NDUFS5/COX7A2/NDUFB8/NDUFC1/NDUFB10/UQCRH/PARK7/NDUFB4/SLC25A5/ATP5PF/NDUFA3/SOD1/NDUFA11/NDUFS7/NDUFB7/ATP5PD/NDUFB3/TUBB/NDUFV2/PSMB6/ATP5PO/NDUFS3/PSMB1/ATP5F1D/NDUFA6/NDUFB1/PSMD8/NDUFS8/PSMB5/NDUFA12/ATP5MC1/COX7A2L	15.0721935324471
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	61/526	227/9376	4.79000351752902	CYBA/ATP5F1E/MT-ATP6/MT-CYB/HGF/MT-CO2/UQCRB/NDUFA4/COX6C/UQCR10/UQCR11/COX6B1/MT-ND1/COX8A/COX7C/NDUFC2/COX7B/NDUFA1/NDUFA13/COX4I1/ATP5MC3/JUN/NDUFB11/NDUFA2/NDUFB2/MT-CO3/COX6A1/ATP5MC2/COX5B/SLC25A6/AKR1A1/NDUFS6/UQCRQ/NDUFS5/COX7A2/NDUFB8/NDUFC1/NDUFB10/UQCRH/NDUFB4/SLC25A5/ATP5PF/NDUFA3/SOD1/NDUFA11/NDUFS7/NDUFB7/ATP5PD/NDUFB3/NDUFV2/ATP5PO/NDUFS3/ATP5F1D/NDUFA6/PTPRJ/NDUFB1/NDUFS8/NDUFA12/ATP5MC1/PLD1/COX7A2L	14.091998970029
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	67/526	308/9376	3.87753691175744	ATP5F1E/MT-ATP6/MT-CYB/MT-CO2/TUBA1B/UQCRB/NDUFA4/COX6C/UQCR10/CLTA/UQCR11/COX6B1/MT-ND1/COX8A/COX7C/NDUFC2/COX7B/NDUFA1/NDUFA13/COX4I1/ATP5MC3/NDUFB11/PSMA7/NDUFA2/NDUFB2/MT-CO3/COX6A1/AP2S1/CLTC/ATP5MC2/COX5B/SLC25A6/NDUFS6/UQCRQ/NDUFS5/COX7A2/NDUFB8/NDUFC1/POLR2L/NDUFB10/UQCRH/NDUFB4/SLC25A5/ATP5PF/NDUFA3/SOD1/NDUFA11/POLR2J/NDUFS7/NDUFB7/ATP5PD/NDUFB3/TUBB/NDUFV2/PSMB6/ATP5PO/NDUFS3/PSMB1/ATP5F1D/NDUFA6/NDUFB1/PSMD8/NDUFS8/PSMB5/NDUFA12/ATP5MC1/COX7A2L	12.5183583855432
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	58/526	235/9376	4.3993851630127	ATP5F1E/MT-ATP6/MT-CYB/MT-CO2/UQCRB/NDUFA4/ATP5MG/COX6C/UQCR10/RPS6/UQCR11/COX6B1/MT-ND1/COX8A/ACTB/COX7C/NDUFC2/COX7B/NDUFA1/NDUFA13/COX4I1/ATP5MC3/NDUFB11/NDUFA2/NDUFB2/MT-CO3/COX6A1/ATP5MF/ATP5MC2/COX5B/NDUFS6/UQCRQ/NDUFS5/COX7A2/NDUFB8/NDUFC1/NDUFB10/UQCRH/NDUFB4/ATP5PF/NDUFA3/NDUFA11/NDUFS7/NDUFB7/ATP5PD/NDUFB3/NDUFV2/ATP5PO/NDUFS3/ATP5F1D/NDUFAF8/ATP5ME/NDUFA6/NDUFB1/NDUFS8/NDUFA12/ATP5MC1/COX7A2L	12.8660230804038
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	47/526	157/9376	5.33617495337967	MT-CYB/MT-CO2/UQCRB/NDUFA4/COX6C/UQCR10/UQCR11/COX6B1/COX8A/COX7C/NDUFC2/COX7B/NDUFA1/NDUFA13/COX4I1/JUN/NDUFB11/NDUFA2/NDUFB2/MT-CO3/COX6A1/COX5B/NDUFS6/UQCRQ/NDUFS5/COX7A2/NDUFB8/NDUFC1/NDUFB10/UQCRH/NDUFB4/NDUFA3/NDUFA11/NDUFS7/NDUFB7/NDUFB3/NDUFV2/NDUFS3/SOCS3/NDUFA6/NDUFB1/BID/NDUFS8/ADIPOR1/TNFRSF1A/NDUFA12/COX7A2L	13.35738950137
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	72/526	388/9376	3.30774959821254	ATP5F1E/MT-ATP6/CYBB/MT-CYB/MT-CO2/TUBA1B/UQCRB/NDUFA4/WNT2/COX6C/UQCR10/CALM2/UQCR11/COX6B1/MT-ND1/COX8A/COX7C/NDUFC2/COX7B/NDUFA1/NDUFA13/COX4I1/ATP5MC3/NDUFB11/PSMA7/SNCA/APOE/NDUFA2/NDUFB2/MT-CO3/COX6A1/ITPR2/ATP5MC2/COX5B/SLC25A6/NDUFS6/CALM3/UQCRQ/NDUFS5/COX7A2/NDUFB8/NDUFC1/NDUFB10/UQCRH/NDUFB4/SLC25A5/ATP5PF/NDUFA3/NDUFA11/NDUFS7/NDUFB7/ATP5PD/NDUFB3/TUBB/NDUFV2/PSMB6/ATP5PO/NDUFS3/PSMB1/ATP5F1D/NDUFA6/NDUFB1/PSMD8/FZD2/BID/NDUFS8/TNFRSF1A/LRP1/PSMB5/NDUFA12/ATP5MC1/COX7A2L	11.3182658291058
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	69/526	368/9376	3.34220532319392	ATP5F1E/MT-ATP6/MT-CYB/MT-CO2/TUBA1B/UQCRB/NDUFA4/COX6C/UQCR10/UQCR11/COX6B1/MT-ND1/COX8A/ACTB/COX7C/NDUFC2/COX7B/NDUFA1/NDUFA13/COX4I1/ATP5MC3/NDUFB11/PSMA7/NDUFA2/NDUFB2/MT-CO3/COX6A1/ATP5MC2/COX5B/NDUFS6/UQCRQ/NDUFS5/COX7A2/NDUFB8/NDUFC1/PFN1/NDUFB10/UQCRH/C9orf72/HNRNPA1/NDUFB4/ATP5PF/NDUFA3/SOD1/TANK/CHCHD10/NDUFA11/NDUFS7/NDUFB7/ATP5PD/NDUFB3/TUBB/NDUFV2/PSMB6/ATP5PO/NDUFS3/PSMB1/ATP5F1D/NDUFA6/NDUFB1/PSMD8/BID/NDUFS8/TNFRSF1A/PSMB5/CASP1/NDUFA12/ATP5MC1/COX7A2L	11.1748463172942
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	79/526	480/9376	2.93371356147022	RPS27A/ATP5F1E/MT-ATP6/CYBB/UBB/MT-CYB/MT-CO2/TUBA1B/UQCRB/NDUFA4/WNT2/UBA52/COX6C/UQCR10/CALM2/UQCR11/COX6B1/MT-ND1/COX8A/COX7C/NDUFC2/COX7B/NDUFA1/NDUFA13/COX4I1/ATP5MC3/NDUFB11/PSMA7/SNCA/NDUFA2/NDUFB2/MT-CO3/COX6A1/ITPR2/ATP5MC2/COX5B/SLC25A6/NDUFS6/CALM3/UQCRQ/NDUFS5/COX7A2/NDUFB8/NDUFC1/RYR2/NDUFB10/UQCRH/PARK7/C9orf72/NDUFB4/SLC25A5/ATP5PF/NDUFA3/SOD1/TANK/NDUFA11/NDUFS7/NDUFB7/ATP5PD/NDUFB3/TUBB/NDUFV2/PSMB6/PRKCB/ATP5PO/NDUFS3/PSMB1/ATP5F1D/NDUFA6/NDUFB1/PSMD8/FZD2/BID/NDUFS8/TNFRSF1A/PSMB5/NDUFA12/ATP5MC1/COX7A2L	10.6028410179287
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	34/526	149/9376	4.0674713552964	NDUFA4/GNG10/GNG11/MT-ND1/GNG2/NDUFC2/GNAI2/NDUFA1/NDUFA13/NDUFB11/NDUFA2/NDUFB2/ITPR2/GNG5/NDUFS6/NDUFS5/NDUFB8/NDUFC1/NDUFB10/GNB2/NDUFB4/NDUFA3/GNGT1/NDUFA11/NDUFS7/NDUFB7/NDUFB3/NDUFV2/PRKCB/NDUFS3/NDUFA6/NDUFB1/NDUFS8/NDUFA12	9.20132275468633
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	22/526	87/9376	4.50749530177877	MT-CYB/MT-CO2/UQCRB/COX6C/UQCR10/UQCR11/COX6B1/COX8A/COX7C/ATP1B1/COX7B/ATP1B3/COX4I1/MT-CO3/COX6A1/COX5B/UQCRQ/COX7A2/RYR2/UQCRH/MYL4/COX7A2L	8.01270433488763
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	16/526	50/9376	5.70403041825095	CD36/HBA2/CCL2/HBA1/HGF/GYPB/CR1/GYPC/CD81/VCAM1/GYPA/ICAM1/TLR4/ITGB2/LRP1/PECAM1	8.13044456297481
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	25/526	155/9376	2.87501533177971	CD14/CD36/CYBA/FCGR3A/CYBB/TUBA1B/MRC1/HLA-C/ACTB/NCF4/FCGR2A/ATP6V0C/FCGR1A/ATP6V0B/ATP6V1F/COLEC12/SEC61B/CLEC7A/TLR4/TUBB/ITGB5/ITGB2/RAB5C/CORO1A/M6PR	5.73836985331021
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	16/526	78/9376	3.65642975528907	C1QA/CD14/C1QB/C1QC/LY96/CALM2/GNAI2/JUN/C2/CALM3/PYCARD/C4BPB/TLR4/NLRP3/ITGB2/CASP1	5.74325026876619
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	27/526	196/9376	2.455497788469	RPS27A/UBB/UBA52/GNG10/CALM2/HLA-C/GNG11/GNG2/JUN/LYN/ITPR2/GNG5/CALM3/CCR1/CDK6/GNB2/SYK/CD86/GNGT1/ICAM1/PREX1/PIK3CG/CCND1/CD200R1/BID/TNFRSF1A/RB1	5.02024740004674
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	20/526	140/9376	2.54644215100489	SPP1/MEF2C/GNG10/CALM2/RPS6/GNG11/GNG2/GNAI2/EGR1/ITPR2/GNG5/CALM3/KLF2/RYR2/GNB2/GNGT1/MYL4/GNA13/PIK3CG/CCND1	4.49430569738405
Organismal Systems	Immune system	hsa04611	Platelet activation	18/526	126/9376	2.54644215100489	COL3A1/FCER1G/COL1A1/ACTB/MYL12A/GNAI2/COL1A2/FCGR2A/LYN/ITPR2/VAMP8/TBXAS1/SYK/GNA13/FERMT3/GUCY1A1/PIK3CG/LCP2	4.26044496649175
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	28/526	250/9376	1.99641064638783	LGMN/CTSC/NPC2/CD63/CLTA/LAPTM5/CD68/BLOC1S1/ATP6V0C/AP2S1/LAMTOR2/CLTC/LAMTOR4/ASAH1/ATP6V0B/VAMP8/CTSZ/ATP6V1F/AP1B1/NEU1/CTBS/LAMTOR5/LAMTOR1/AP1S2/FUCA1/MANBA/TLR7/M6PR	3.89291576241936
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	23/526	193/9376	2.12423412596781	CXCL14/CCL2/CCL3/CCL4L2/CCL4/GNG10/GNG11/GNG2/GNAI2/LYN/GNG5/CCL3L1/CCR1/DOCK2/GNB2/GNGT1/CCL13/ARRB2/PRKCB/CX3CR1/PREX1/PIK3CG/CCL8	3.84724639503642
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	27/526	248/9376	1.94063534895131	CD14/TUBA1B/LY96/ARPC3/ACTB/ARPC1B/MYL12A/JUN/DYNLL1/PYCARD/PFN1/ARPC5/BRK1/CYFIP1/DYNLRB1/CYTH4/TLR4/ACTR2/TUBB/NLRP3/RHOG/PIK3CG/RAB5C/NCKAP1L/TNFRSF1A/CASP1/M6PR	3.65987451461304
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	25/526	227/9376	1.96311619570861	CCL2/CCL3/CCL4L2/CCL4/GNG10/CALM2/HLA-C/GNG11/GNG2/B2M/GNAI2/ITPR2/GNG5/CCL3L1/CALM3/CCR1/CDK6/GNB2/GNGT1/GNA13/PRKCB/CCND1/BID/TNFRSF1A/RB1	3.58106064418452
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	24/526	216/9376	1.98056611744825	CD14/CD36/CYBA/CCL2/CCL3/CYBB/LY96/CALM2/NCF4/JUN/LYN/VCAM1/CCL3L1/CALM3/PYCARD/POU2F2/TANK/ICAM1/TLR4/HSPA8/NLRP3/BID/TNFRSF1A/CASP1	3.55437214042362
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	14/526	98/9376	2.54644215100489	FCGR3A/MARCKS/ARPC3/ARPC1B/FCGR2A/LYN/FCGR1A/PLPP3/ARPC5/SYK/BIN1/ACTR2/PRKCB/PLD1	3.75168534934159
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	13/526	88/9376	2.63325267888006	F13A1/C1QA/C1QB/C1QC/CFD/CR1/VSIG4/A2M/C3AR1/C2/C4BPB/ITGB2/PROS1	3.75267096315497
NA	NA	hsa04518	Integrin signaling	18/526	154/9376	2.083452669004	SPP1/COL1A1/HGF/LAMA2/ACTB/COL6A1/PDGFC/COL1A2/VCAM1/CCND2/IGF1/ICAM1/FERMT3/ITGB5/ITGB2/CCND1/FREM1/COL6A6	3.30494791994773
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	11/526	78/9376	2.51379545676124	CYBA/FCGR3A/CYBB/CR1/NCF4/JUN/FCGR2A/FCGR1A/TLR4/PRKCB/ITGB2	3.27285377924662
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	22/526	214/9376	1.83248640773249	GNG10/CALM2/HLA-C/GNG11/ELOB/GNG2/B2M/GNAI2/JUN/ITPR2/GNG5/CALM3/CD4/RBX1/GNB2/GNGT1/AP1B1/TLR4/PRKCB/AP1S2/BID/TNFRSF1A	3.00327962164087
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	16/526	138/9376	2.06667768777208	CCL2/ARPC3/ACTB/ARPC1B/JUN/FCGR2A/PYCARD/FYB1/CD4/ARPC5/TLR4/ACTR2/NLRP3/RHOG/CASP1/LCP2	3.07744748033955
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/526	70/9376	2.54644215100489	LAMA2/HLA-C/ACTB/CD28/CD86/SGCE/ICAM1/ITGB2/CCND1/BID	3.16597914308027
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	13/526	105/9376	2.2069165308709	CD14/CCL4L2/CCL4/LY96/EDA/LYN/VCAM1/SYK/ICAM1/CCL13/TLR4/PRKCB/TNFRSF1A	3.03190416544739
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	16/526	142/9376	2.0084614148771	CYBA/TYROBP/FCGR3A/CSF1R/NCF4/JUNB/JUN/FCGR2A/FCGR1A/ITPR2/SYK/LILRB5/SPI1/SOCS3/TNFRSF1A/LCP2	2.95199350880318
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	19/526	181/9376	1.87114257504779	CD14/FCER1G/FCGR3A/MRC1/CR1/CALM2/FCGR2A/ATP6V0C/FCGR1A/ATP6V0B/CALM3/SYK/CLEC7A/TLR4/ITGB2/BID/RAB5C/TNFRSF1A/CORO1A	2.88509112598078
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	12/526	95/9376	2.25159095457274	CCL2/CCL3/JUN/ATP6V0C/CD28/CCL3L1/ATP6V0B/ATP6V1F/CD86/ICAM1/TLR4/ITGB2	2.98905362817245
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	24/526	250/9376	1.71120912547529	DAB2/FOLR2/WWP1/ARPC3/CLTA/HLA-C/SNX6/ARPC1B/SNX3/SNX2/AP2S1/CLTC/CAPZB/ARPC5/EPS15/VPS28/CYTH4/BIN1/ACTR2/ARRB2/HSPA8/RAB5C/PLD1/RAB11A	2.77865077513591
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	12/526	97/9376	2.20516639880836	GNG10/CALM2/GNG11/GNG2/GNAI2/GNG5/CALM3/RYR2/GNB2/GNGT1/GUCY1A1/PRKCB	2.90863462216545
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/526	42/9376	2.97084917617237	FTL/CYBB/NCOA4/SLC40A1/FTH1/GPX4/GCLM	3.12069275003063
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/526	53/9376	2.69058038596743	CLTA/ATP1B1/ATP1B3/AP2S1/CLTC/ATP2B1/PRKCB/RAB11A	3.00886563127557
NA	NA	hsa04517	IgSF CAM signaling	27/526	299/9376	1.60962396836095	TUBA1B/NRP1/MTSS1/SLIT2/ARPC3/CADM3/ACTB/ARPC1B/MYL6/MYL12A/PMP22/LYN/CD28/DYNLL1/UNC5C/ARPC5/ANK2/CD86/PTPRD/ICAM1/ACTR2/TUBB/PRKCB/DOK2/EPB41L3/ITGB2/LCP2	2.61176041379537
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/526	100/9376	2.13901140684411	CXCL14/CCL2/CCL3/CCL4L2/CCL4/CSF1R/CCL3L1/CCR1/CCL13/CX3CR1/CCL8/TNFRSF1A	2.79160892653507
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/526	56/9376	2.54644215100489	CD14/CR1/EEF1G/PYCARD/TLR4/HSPA8/ITGB2/CASP1	2.82961019068341
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/526	116/9376	1.99763996328832	CYBA/CYBB/ACTB/NCF4/MYL12A/GNAI2/VCAM1/ARHGAP5/ICAM1/PRKCB/ITGB2/PECAM1/THY1	2.63574999224458
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	19/526	195/9376	1.73680413376231	CYBA/FCGR3A/CYBB/CR1/ACTB/NCF4/FCGR2A/FCGR1A/HDAC9/SLC25A6/HMGB1/SLC25A5/SYK/CLEC7A/TLR4/PRKCB/ITGB2/CASP1/TLR7	2.53472729005081
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/526	142/9376	1.88293257644728	CYBA/CCL2/MEF2C/CALM2/ACTB/JUN/VCAM1/CALM3/KLF2/SUMO2/BMP4/ICAM1/SUMO1/TNFRSF1A/PECAM1	2.5845423492984
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	19/526	200/9376	1.69338403041825	TUBA1B/ARPC3/ACTB/ARPC1B/JUN/FCGR2A/PYCARD/ARPC5/BRK1/CYFIP1/CYTH4/TLR4/ACTR2/TUBB/GNA13/NLRP3/NCKAP1L/TNFRSF1A/CASP1	2.41640099203296
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	12/526	109/9376	1.96239578609551	SPP1/CD14/CCL3/CCL4L2/CCL4/LY96/JUN/CCL3L1/CD86/MAP3K8/TLR4/TLR7	2.46379321641379
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	19/526	204/9376	1.66018042197868	LUM/DCN/COL1A1/HGF/WNT2/CD63/RPS6/ACTB/COL1A2/ITPR2/GPC3/IGF1/ANK2/TLR4/PRKCB/ITGB5/TWIST1/FZD2/CCND1	2.32408804418961
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	11/526	99/9376	1.98056611744825	C1QA/C1QB/C1QC/FCGR3A/CFD/FCGR2A/FCGR1A/C3AR1/C2/ICAM1/ITGB2	2.39109910257698
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	11/526	101/9376	1.94134698640967	COL3A1/CCL2/CYBB/COL1A1/JUN/EGR1/COL1A2/VCAM1/ICAM1/PRKCB/CCND1	2.31878423643501
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	10/526	89/9376	2.00281966932969	GNG10/GABARAP/GNG11/GNG2/GNAI2/GABARAPL2/GNG5/GNB2/GNGT1/PRKCB	2.31732527827173
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	5/526	31/9376	2.87501533177971	SRP14/SEC11A/SPCS1/SEC61B/SPCS2	2.54919402714227
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	11/526	103/9376	1.90365092842113	COL3A1/COL1A1/COL14A1/SLC16A10/ATP1B1/COL6A1/ATP1B3/COL15A1/COL1A2/COL21A1/COL6A6	2.24810223053297
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	11/526	105/9376	1.86739091073692	RPS27A/UBB/UBA52/GABARAP/TOMM7/JUN/GABARAPL2/FKBP8/FIS1/TOMM20/RAB5C	2.17897928155544
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/526	105/9376	1.86739091073692	FCER1G/CALM2/JUN/ITPR2/CALM3/PYCARD/SYK/CLEC7A/NLRP3/CASP1/EGR2	2.17897928155544
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	29/526	362/9376	1.42797722832595	SPP1/COL1A1/HGF/CSF1R/LAMA2/GNG10/RPS6/GNG11/GNG2/COL6A1/PDGFC/COL1A2/CCND2/GNG5/AREG/IGF1/YWHAB/LPAR6/CDK6/GNB2/PIK3AP1/SYK/GNGT1/TLR4/ITGB5/PIK3CG/CCND1/KITLG/COL6A6	2.02452453895732
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	18/526	201/9376	1.59627716928665	CD14/MEF2C/CSF1R/MAF/NR4A3/RUNX1/BMP2K/DUSP6/FCGR1A/CCND2/LMO2/IGF1/LYL1/PROM1/CD86/SPI1/ETV5/FLI1	2.08329153040934
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	16/526	173/9376	1.64856370469681	CCL2/ACTB/SLC25A6/PYCARD/CDK6/SLC25A5/ICAM1/TLR4/PRKCB/SOCS3/NLRP3/BID/TNFRSF1A/CASP1/TLR7/RAB11A	2.09902618444817
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/526	93/9376	1.91667688785314	CST3/CALM2/ATP1B1/ATP1B3/ITPR2/CALM3/ATP2B1/GUCY1A1/PRKCB/ADRB1	2.16581050369013
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/526	46/9376	2.32501239874359	PSMA7/POMP/PSMB6/PSMB1/PSMD8/PSMB5	2.19616472242908
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	6/526	47/9376	2.27554404983416	LDHB/AKR1A1/HAGH/GLO1/MDH1/ALDH9A1	2.13714366930081
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	21/526	253/9376	1.47955334465501	CD14/RPS27A/UBB/UBA52/ARPC3/ACTB/ARPC1B/MYL12A/JUN/ITPR2/PYCARD/PFN1/ARPC5/RBX1/CYTH4/TLR4/ACTR2/NLRP3/TNFRSF1A/CASP1/SEPTIN7	1.88510359832927
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/526	60/9376	2.07959442332066	GNAI2/LYN/ITPR2/IGF1/GNA13/GUCY1A1/PRKCB	2.04516519266034
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/526	61/9376	2.04550271146294	FTL/SLC40A1/FTH1/ATP1B1/ATP1B3/ATOX1/ATP2B1	1.99712627882758
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/526	37/9376	2.40879662932895	HBA2/HBA1/VCAM1/ICAM1/PRKCB	2.09317651370021
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	12/526	130/9376	1.64539338988008	COL3A1/COL1A1/GNG10/GNG11/GNG2/GNAI2/JUN/COL1A2/GNG5/GNB2/GNGT1/ARRB2	1.8064507244504
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	9/526	89/9376	1.80253770239672	SPP1/CD36/COL1A1/LAMA2/COL6A1/COL1A2/ITGB5/FREM1/COL6A6	1.85451179450153
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/526	89/9376	1.80253770239672	TUBA1B/GNAI2/PDGFC/ITPR2/GJA1/TUBB/GUCY1A1/PRKCB/ADRB1	1.85451179450153
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/526	76/9376	1.87632579547729	CALM2/ACTB/ATP1B1/ATP1B3/GNAI2/ITPR2/CALM3/PRKCB	1.86998357763929
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/526	103/9376	1.73059175311012	C1QA/CCL2/C1QB/CCL3/C1QC/GNAI2/JUN/CCL3L1/TLR4/TNFRSF1A	1.81756571937081
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	17/526	203/9376	1.49274195058907	SPP1/COL1A1/HGF/LAMA2/ACTB/MYL12A/COL6A1/PDGFC/JUN/COL1A2/CCND2/IGF1/ARHGAP5/PRKCB/ITGB5/CCND1/COL6A6	1.73028935332501
Human Diseases	Substance dependence	hsa05032	Morphine addiction	9/526	91/9376	1.76292148915723	GNG10/GNG11/GNG2/GNAI2/GNG5/GNB2/GNGT1/ARRB2/PRKCB	1.78285681250862
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/526	52/9376	2.0567417373501	CD36/PLTP/NPC2/TSPO/APOE/LRP1	1.86284308963734
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/526	133/9376	1.60827925326625	GNG10/CALM2/GNG11/GNG2/GNAI2/ITPR2/GNG5/CALM3/GNB2/GNGT1/ARRB2/PRKCB	1.72238098803299
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/526	78/9376	1.82821487764454	ARPC3/CLTA/ACTB/ARPC1B/CLTC/ARPC5/ACTR2/RHOG	1.79061588553488
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/526	18/9376	2.97084917617237	NEU1/FUCA1/MANBA	2.04035152622782
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	18/526	224/9376	1.43237370994025	NRP1/HLA-C/B2M/JUN/EGR1/TSPO/CCND2/SLC25A6/ANAPC11/CD4/SLC25A5/SPI1/ICAM1/ITGB2/CCND1/TNFRSF1A/EGR2/RB1	1.5967324726619
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	14/526	166/9376	1.50332126987036	MEF2C/CALM2/ATP1B1/ATP1B3/GNAI2/ITPR2/SLC25A6/CALM3/ATP2B1/SLC25A5/GNA13/GUCY1A1/PIK3CG/ADRB1	1.59505766161686
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/526	68/9376	1.83493625587117	CD14/CSF1R/RUNX1/DUSP6/FCGR1A/SPI1/CCND1	1.68455992206653
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	13/526	154/9376	1.50471581650289	MEF2C/CALM2/ACTB/MYL6/GNAI2/JUN/ITPR2/CALM3/RYR2/GUCY1A1/PRKCB/PIK3CG/CCND1	1.53957762589607
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	13/526	157/9376	1.47596328497736	C1QA/CD36/C1QB/C1QC/STAB1/CX3CR1/ITGB5/GAS6/RAB5C/LRP1/CASP1/PROS1/PECAM1	1.46618322695649
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	15/526	187/9376	1.42982045912039	CYBA/CCL2/CYBB/GABARAP/IFI16/JUN/ITPR2/GABARAPL2/GPSM3/PYCARD/CARD16/TANK/TLR4/NLRP3/CASP1	1.44737356434519
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/526	100/9376	1.60425855513308	CD14/CD36/CSF1R/CR1/FCGR1A/GYPA/CD4/CD37/KITLG	1.48098040661288
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	12/526	144/9376	1.48542458808618	C1QA/CD14/C1QB/C1QC/LY96/C3AR1/C2/TLR4/ALDH9A1/CCND1/ADIPOR1/TNFRSF1A	1.43107367830786
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	10/526	115/9376	1.55000826582906	GNG10/GNG11/GNG2/GNAI2/ITPR2/GNG5/GNB2/GNGT1/PRKCB/PIK3CG	1.44675858912477
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/526	115/9376	1.55000826582906	MEF2C/NACA/GNAI2/EGR1/ITPR2/NR4A2/GNA13/ARRB2/PRKCB/PLD1	1.44675858912477
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	10/526	116/9376	1.5366461256064	GNG10/GNG11/GNG2/GNAI2/ITPR2/GNG5/GNB2/GNGT1/PRKCB/PLD1	1.41781110766948
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	9/526	103/9376	1.55753257779911	CD14/COL3A1/COL1A1/LAMA2/COL1A2/TLR4/PRKCB/ITGB2/RAB5C	1.38702920820865
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/526	133/9376	1.47425598216072	FCER1G/HCST/TYROBP/FCGR3A/HLA-C/SYK/ICAM1/PRKCB/ITGB2/BID/LCP2	1.34288566106497
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/526	76/9376	1.64178507104263	CALM2/CALM3/IGF1/CDK6/PRKCB/CCND1/RB1	1.36949927688724
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/526	23/9376	2.32501239874359	ATP1B1/ATP1B3/MDH1	1.55101239296884
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/526	79/9376	1.57943880252202	CLTA/SYT1/ATP6V0C/AP2S1/CLTC/ATP6V0B/ATP6V1F	1.26083013343157
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	12/526	154/9376	1.38896844600267	CALM2/ATP1B1/ATP1B3/GNAI2/CALM3/RYR2/ATP2B1/CREM/MYL4/SCN1B/PIK3CG/ADRB1	1.18650356708574
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/526	51/9376	1.74755833892492	ACTB/ATP6V0C/ATP6V0B/ATP6V1F/SEC61B	1.30500637460193
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	17/526	233/9376	1.30054341617846	COL3A1/DCN/COL1A1/LAMA2/ACTB/ATP1B1/COL6A1/ATP1B3/COL1A2/CAPZB/VCAN/TNNT3/ANK2/SGCE/MYL4/ITGB5/COL6A6	1.13252473006651
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/526	38/9376	1.87632579547729	ATP1B1/ATP1B3/IGF1/PRKCB	1.31958489062669
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/526	110/9376	1.4584168683028	CYBB/RPS6/ELOB/LDHB/MKNK1/IGF1/RBX1/TLR4/PRKCB	1.17901046378754
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	11/526	142/9376	1.380817222728	RPS27A/UBB/WWP1/UBA52/ELOB/ANAPC11/RBX1/UBE2B/SOCS3/PIAS2/UBE2W	1.11473771127924
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	17/526	238/9376	1.27322107550244	HGF/CSF1R/GNG10/CALM2/GNG11/GNG2/PDGFC/GNG5/CALM3/IGF1/GNB2/RGL1/GNGT1/PRKCB/KITLG/RAB5C/PLD1	1.04083999789219
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/526	83/9376	1.50332126987036	CCL4L2/CCL4/IFI16/PYCARD/POLR2L/NLRP3/CASP1	1.12282800537027
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/526	98/9376	1.45510980057422	CALM2/ATP1B1/ATP1B3/ITPR2/CALM3/ATP2B1/NR4A2/PRKCB	1.10410128826777
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	12/526	160/9376	1.33688212927757	HLA-C/CADM3/VCAM1/CD28/VCAN/CD4/CD86/PTPRD/ICAM1/SIGLEC1/ITGB2/PECAM1	1.04778844951205
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/526	69/9376	1.55000826582906	CALM2/GNAI2/ITPR2/CALM3/GUCY1A1/ADRB1	1.11788152753745
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	9/526	115/9376	1.39500743924616	GNG10/GNG11/GNG2/GNAI2/ITPR2/GNG5/GNB2/GNGT1/PRKCB	1.03903966722414
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/526	56/9376	1.59152634437806	KRTCAP2/DAD1/ST6GAL1/TMEM258/OSTC	1.08234826050377
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/526	28/9376	1.90983161325367	SLC4A1/ATP6V0C/ATP6V1F	1.17540507524132
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	15/526	212/9376	1.26120955592223	HGF/CSF1R/CALM2/ACTB/GNAI2/PDGFC/CALM3/IGF1/FYB1/PFN1/PRKCB/SIPA1L2/ITGB2/KITLG/LCP2	0.9378239640115
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/526	29/9376	1.84397535072768	CALM2/CALM3/GNGT1	1.10968448822591
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/526	73/9376	1.46507630605761	HGF/PDGFC/IGF1/CDK6/CCND1/RB1	0.972480739981571
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/526	73/9376	1.46507630605761	HGF/CDK6/RARB/PRKCB/CCND1/RB1	0.972480739981571
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/526	44/9376	1.62046318700311	KRTCAP2/DAD1/TMEM258/OSTC	1.00568475637224
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/526	136/9376	1.31066875419369	RACK1/JUN/CD28/CCND2/CDK6/TLR4/HSPA8/CCND1/BID/TLR7	0.88968838200769
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	12/526	168/9376	1.27322107550244	FTL/CYBB/FTH1/SLC25A6/PYCARD/HMGB1/SLC25A5/TLR4/NLRP3/BID/TNFRSF1A/CASP1	0.871150232830399
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	7/526	91/9376	1.3711611582334	CD81/JUN/LYN/PIK3AP1/SYK/LILRB5/PRKCB	0.867359497536234
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/526	46/9376	1.55000826582906	FTL/BLVRB/FTH1/ALAS2	0.911620715099382
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/526	93/9376	1.3416738214972	CALM2/JUN/EGR1/ITPR2/CALM3/PRKCB/PLD1	0.807264545708865
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	9/526	125/9376	1.28340684410646	FCER1G/GNAI2/ASAH1/SGMS1/GNA13/PRKCB/BID/TNFRSF1A/PLD1	0.777638716780529
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	11/526	158/9376	1.24098763055302	WNT2/RPS6/LAMTOR2/LAMTOR4/IGF1/ATP6V1F/LAMTOR5/LAMTOR1/PRKCB/FZD2/TNFRSF1A	0.744752240013514
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/526	63/9376	1.4146900838916	PTGDS/HPGDS/LTC4S/GPX4/TBXAS1	0.805111442049866
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	10/526	144/9376	1.23785382340515	RBPJ/PSMA7/ITPR2/SLC25A6/SLC25A5/PSMB6/PRKCB/PSMB1/PSMD8/PSMB5	0.701213647421521
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/526	80/9376	1.33688212927757	HGF/RPS6/PDGFC/IGF1/PRKCB/GAS6	0.737703398668021
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	12/526	178/9376	1.20169180159781	SERPINF1/WNT2/JUN/CCND2/RSPO2/RBX1/PRICKLE1/BAMBI/FRZB/PRKCB/FZD2/CCND1	0.662305587193564
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/526	65/9376	1.3711611582334	SPP1/ITPR2/KISS1/ARRB2/PRKCB	0.73202836766268
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/526	51/9376	1.39804667113994	ENPP2/PLPP3/CEPT1/PLD1	0.694866763139494
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	15/526	232/9376	1.1524845942048	TMSB4X/ARPC3/ACTB/ARPC1B/MYL12A/PDGFC/PFN1/ARPC5/BRK1/CYFIP1/ACTR2/GNA13/ITGB5/ITGB2/NCKAP1L	0.573335359542883
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	10/526	149/9376	1.19631510449894	FCER1G/PDGFC/PLPP3/LPAR6/SYK/CYTH4/GNA13/PIK3CG/KITLG/PLD1	0.588875470669289
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/526	101/9376	1.23540262771524	WNT2/CALM2/GNAI2/CALM3/PRKCB/FZD2/KITLG	0.579858341548816
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/526	102/9376	1.22329083724745	ATP1B1/ATP1B3/ITPR2/RYR2/ATP2B1/PRKCB/RAB11A	0.552769811935227
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	8/526	119/9376	1.19832571811995	CCL2/JUNB/JUN/VCAM1/MAP3K8/ICAM1/SOCS3/TNFRSF1A	0.530791866326106
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/526	22/9376	1.62046318700311	HNMT/ALDH9A1	0.710289757013733
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/526	86/9376	1.2436112830489	LAMA2/ACTB/GJA1/RYR2/SGCE/ITGB5	0.553280854936045
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	11/526	170/9376	1.15338850369045	TUBA1B/ARPC3/ACTB/ARPC1B/MYL6/MYL12A/JUN/RUNX1/ARPC5/ACTR2/CCND1	0.492026689464806
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	13/526	205/9376	1.13037188166558	RBPJ/HLA-C/B2M/JUN/LYN/CCND2/CDK6/SYK/ICAM1/PSMD8/CCND1/BID/RB1	0.460107584699373
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	13/526	205/9376	1.13037188166558	RBPJ/HLA-C/JUN/LYN/HDAC9/CCND2/YWHAB/CDK6/SYK/HNRNPK/CCND1/EGR2/RB1	0.460107584699373
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/526	71/9376	1.25528838429818	JUN/LYN/ATP6V0C/ATP6V0B/ATP6V1F	0.526391557520495
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/526	55/9376	1.29637054960249	ASAH1/PLPP3/SGMS1/NEU1	0.537393007590864
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/526	23/9376	1.55000826582906	RPA3/SSBP1	0.643820116208028
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/526	105/9376	1.18833967046895	LAMA2/ACTB/IGF1/RYR2/SGCE/ITGB5/ADRB1	0.473129513771546
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/526	39/9376	1.3711611582334	HLA-C/CD28/CD86	0.566236707929906
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/526	56/9376	1.27322107550244	DISP1/CCND2/ARRB2/CCND1	0.499927617110556
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	10/526	157/9376	1.1353563730595	CALM2/HLA-C/ITPR2/CCND2/SLC25A6/CALM3/CDK6/SLC25A5/CCND1/RB1	0.416959143920002
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	10/526	157/9376	1.1353563730595	BMP5/WNT2/ACTB/CCND2/AREG/YWHAB/BMP4/ITGB2/FZD2/CCND1	0.416959143920002
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	9/526	143/9376	1.12185912946369	C1QA/C1QB/C1QC/FCGR3A/FCGR2A/FCGR1A/CD28/C2/CD86	0.357982294360614
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/526	75/9376	1.18833967046895	CCND2/IGF1/CDK6/CCND1/BID	0.399222022641788
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/526	110/9376	1.13432423090218	DCN/BMP5/PITX2/BMP4/RBX1/BAMBI/ID3	0.345470868819062
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/526	59/9376	1.20848102081588	HPGDS/LAP3/GPX4/GCLM	0.391616839237277
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/526	10/9376	1.78250950570342	SELENBP1	0.603558568943629
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/526	112/9376	1.11406844106464	LY96/LAMA2/GNAI2/TLR4/HSPA8/PIK3CG/TNFRSF1A	0.296061625524709
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/526	44/9376	1.21534739025233	HLA-C/CD28/CD86	0.349048246919168
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/526	44/9376	1.21534739025233	DYNLL1/RAB5C/RAB11A	0.349048246919168
NA	NA	hsa04081	Hormone signaling	13/526	219/9376	1.05811066548605	SLC40A1/GNG10/GNG11/GNG2/SLC16A10/GNAI2/GNG5/IGF1/GNB2/GNGT1/GNA13/ADIPOR1/ADRB1	0.212132970913439
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/526	45/9376	1.18833967046895	HLA-C/CD28/CD86	0.308738538033592
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/526	63/9376	1.13175206711328	POLR2L/RBX1/RPA3/POLR2J	0.255793665841196
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6/526	99/9376	1.08030879133541	CALM2/ITPR2/CALM3/IGF1/HRH1/PRKCB	0.195832056068641
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/526	99/9376	1.08030879133541	LAMA2/ACTB/IGF1/RYR2/SGCE/ITGB5	0.195832056068641
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/526	82/9376	1.08689604006306	LGMN/HLA-C/B2M/CD4/HSPA8	0.19266927036831
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/526	65/9376	1.09692892658672	AKR1A1/AKR1B1/PLPP3/ALDH9A1	0.191169583170538
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	19/526	333/9376	1.01704746571667	SPP1/COL1A1/WNT2/RBPJ/LAMA2/HLA-C/COL6A1/COL1A2/ATP6V0C/CCND2/ATP6V0B/ATP6V1F/CDK6/ITGB5/FZD2/CCND1/TNFRSF1A/COL6A6/RB1	0.0772204898029313
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	8/526	137/9376	1.04088146318448	CTSC/TUBA1B/ACTB/JUN/ITPR2/CTSZ/BID/TNFRSF1A	0.117511699202055
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	17/526	298/9376	1.0168678388241	CXCL14/CCL2/CCL3/BMP5/CCL4L2/CCL4/CSF1R/IL12RB2/EDA/CCL3L1/CCR1/CD4/BMP4/CCL13/CX3CR1/CCL8/TNFRSF1A	0.0721405352639678
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/526	48/9376	1.11406844106464	ATP1B1/ATP1B3/PRKCB	0.193151787283207
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/526	66/9376	1.08030879133541	MAF/IL12RB2/JUN/TLR4	0.159612570550727
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	8/526	138/9376	1.03333884388604	CALM2/ITPR2/CALM3/IGF1/ANAPC11/YWHAB/RBX1/CPEB4	0.0961851384824833
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	9/526	156/9376	1.02837086867505	CD81/EIF3E/YWHAB/CDK6/SOCS3/CCND1/BID/TNFRSF1A/RB1	0.0871116714959609
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	17/526	300/9376	1.01008871989861	CD14/HGF/MEF2C/CSF1R/PDGFC/JUN/DUSP6/MKNK1/AREG/IGF1/STMN1/MAP3K8/ARRB2/PRKCB/HSPA8/KITLG/TNFRSF1A	0.0432968522108974
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/526	85/9376	1.04853500335495	ENPP1/NME2/GUK1/APRT/NME3	0.109582239497293
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/526	67/9376	1.06418477952443	LDHB/AKR1A1/BPGM/ALDH9A1	0.128536010117442
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/526	67/9376	1.06418477952443	CALM2/ITPR2/CALM3/PRKCB	0.128536010117442
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/526	49/9376	1.09133235043067	ST6GAL1/COLGALT1/GXYLT2	0.156263864648933
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/526	31/9376	1.15000613271189	AKR1A1/ALDH9A1	0.203942192398443
NA	NA	hsa04981	Folate transport and metabolism	2/526	31/9376	1.15000613271189	FOLR2/SLCO2B1	0.203942192398443
Cellular Processes	Cell motility	hsa04814	Motor proteins	11/526	194/9376	1.0107012661205	TUBA1B/ACTB/MYL6/MYL12A/DYNLL1/CAPZB/TNNT3/DYNLRB1/MYL4/TUBB/KIF1B	0.0367175977698121
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/526	122/9376	1.02275135573147	ACTB/SLC16A10/ATP1B1/ATP1B3/BMP4/PRKCB/CCND1	0.0616636635869179
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/526	32/9376	1.11406844106464	GABARAP/GABARAPL2	0.157572692286963
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/526	32/9376	1.11406844106464	BID/TNFRSF1A	0.157572692286963
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/526	69/9376	1.03333884388604	FCER1G/LYN/SYK/LCP2	0.0677605775132911
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/526	69/9376	1.03333884388604	CALM2/JUN/CALM3/PRKCB	0.0677605775132911
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	6/526	106/9376	1.00896764473779	FOLR2/PDGFC/IGF1/ETV5/CCND1/RB1	0.0226359296437435
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/526	70/9376	1.01857686040196	CD36/SOCS3/ADIPOR1/TNFRSF1A	0.0380317831729347
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/526	70/9376	1.01857686040196	HGF/ELOB/JUN/RBX1	0.0380317831729347
NA	NA	hsa04082	Neuroactive ligand signaling	11/526	199/9376	0.985306761946615	GNG10/GNG11/GNG2/GNAI2/GNG5/GNB2/HRH1/GNGT1/PRKCB/OGFRL1/ADRB1	-0.0510740811496961
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/526	34/9376	1.04853500335495	POLR2L/POLR2J	0.0691164567478196
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/526	34/9376	1.04853500335495	RBX1/BHLHE41	0.0691164567478196
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/526	54/9376	0.990283058724123	LDHB/MDH1/GCLM	-0.0174573686722991
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/526	54/9376	0.990283058724123	HLA-C/CD28/CD86	-0.0174573686722991
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/526	93/9376	0.958338443926571	RBPJ/MAF/IL12RB2/JUN/CD4	-0.098432759611982
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	5/526	93/9376	0.958338443926571	LAMA2/CDK6/RARB/CCND1/RB1	-0.098432759611982
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/526	36/9376	0.990283058724123	AKR1A1/AKR1B1	-0.0142401402051278
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/526	36/9376	0.990283058724123	RPA3/SSBP1	-0.0142401402051278
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	9/526	169/9376	0.949265417238509	RPS27A/UBB/UBA52/GABARAP/GABARAPL2/VAMP8/HMGB1/C9orf72/TANK	-0.162253938964886
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/526	75/9376	0.950671736375158	ATP1B1/ATP1B3/ITPR2/PRKCB	-0.104560707410622
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/526	37/9376	0.96351865173158	NCOA4/CCND1	-0.0542036371991812
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/526	17/9376	1.04853500335495	INMT	0.0488283080674545
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	7/526	134/9376	0.931161682083877	CALM2/MYL6/ITPR2/CALM3/GNA13/GUCY1A1/PRKCB	-0.195662023991017
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/526	77/9376	0.925978964001778	CDK6/CCND1/PLD1/RB1	-0.158997125513951
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/526	77/9376	0.925978964001778	RUNX1/CDK6/CCND1/RB1	-0.158997125513951
Human Diseases	Substance dependence	hsa05034	Alcoholism	10/526	191/9376	0.933251050106504	GNG10/CALM2/GNG11/GNG2/GNAI2/HDAC9/GNG5/CALM3/GNB2/GNGT1	-0.227210509688708
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/526	18/9376	0.990283058724123	MMADHC	-0.0100596109546065
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/526	59/9376	0.906360765611909	ENPP1/NME2/NME3	-0.17589467307937
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/526	99/9376	0.900257326112839	PDGFC/JUN/PLPP3/PRKCB/PLD1	-0.243221353233027
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	13/526	254/9376	0.912308014730098	HGF/CALM2/PDGFC/ITPR2/SLC25A6/CALM3/RYR2/ATP2B1/HRH1/SLC25A5/PRKCB/CYSLTR1/ADRB1	-0.345412938622918
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/526	41/9376	0.86951683205045	ALAS2/BPGM	-0.204124970213111
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/526	41/9376	0.86951683205045	RPA3/SSBP1	-0.204124970213111
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/526	41/9376	0.86951683205045	CCND1/RB1	-0.204124970213111
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/526	62/9376	0.862504599533914	IGF1/SOD1/HSPA8	-0.264802922048928
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/526	20/9376	0.891254752851711	NPL	-0.118682599704342
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/526	122/9376	0.876644019198404	GNAI2/JUNB/ITPR2/IGF1/PRKCB/SOCS3	-0.334335315721947
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/526	42/9376	0.848814050334963	INMT/ALDH9A1	-0.239391680870517
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/526	63/9376	0.848814050334963	PRDM6/COLGALT1/ALDH9A1	-0.293524110367474
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/526	63/9376	0.848814050334963	WNT2/BMP4/FZD2	-0.293524110367474
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/526	21/9376	0.848814050334963	ENPP1	-0.169085380300477
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/526	43/9376	0.829074188699266	CD36/PLPP3	-0.273866000685085
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/526	86/9376	0.829074188699266	ATP1B1/ATP1B3/RYR2/PRKCB	-0.38820032398961
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	6/526	128/9376	0.835551330798479	ENPP1/NME2/GUK1/APRT/GUCY1A1/NME3	-0.456686645959427
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	7/526	148/9376	0.843078820265132	WNT2/JUN/IGF1/CDK6/FZD2/CCND1/RB1	-0.469100076963731
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/526	23/9376	0.775004132914531	IDI1	-0.263372160552788
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/526	23/9376	0.775004132914531	ATP6AP2	-0.263372160552788
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	8/526	170/9376	0.838828002683963	HGF/WNT2/ACTB/CDK6/PRKCB/FZD2/CCND1/RB1	-0.516993923050947
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/526	90/9376	0.792226446979299	JUN/CD28/CD4/TLR4	-0.482840906330009
NA	NA	hsa03272	Virion - Hepatitis viruses	2/526	48/9376	0.742712294043092	CD63/CD81	-0.435664586872121
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/526	133/9376	0.804139626633123	GABARAP/CCND2/GABARAPL2/IGF1/KLF2/CCND1	-0.554590973775158
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	8/526	174/9376	0.819544600323412	KRTCAP2/DAD1/RBX1/SEC61B/TMEM258/OSTC/HSPA8/HERPUD1	-0.58574726085472
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/526	71/9376	0.753173030578911	CCND2/SOCS3/CCND1	-0.5089445539358
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/526	49/9376	0.727554900287111	GNAI2/JUN	-0.466136303128636
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/526	155/9376	0.80500429289832	WNT2/GNAI2/ITPR2/CDK6/FZD2/CCND1/RB1	-0.596772446705866
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/526	50/9376	0.713003802281369	LAP3/ALDH9A1	-0.496044129791893
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/526	50/9376	0.713003802281369	CD28/CD86	-0.496044129791893
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/526	27/9376	0.660188705816082	ELOVL2	-0.43106621520457
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/526	158/9376	0.78971940126101	CCND2/ANAPC11/YWHAB/CDK6/RBX1/CCND1/RB1	-0.649854710728788
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/526	138/9376	0.775004132914531	CALM2/RPS6/MKNK1/CALM3/SOCS3/PRKAR1A	-0.649130446981784
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/526	52/9376	0.685580579116701	IGF1/HSD17B2	-0.554264135444268
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	8/526	180/9376	0.792226446979299	CCL2/HLA-C/B2M/POU2F2/SYK/SOCS3/BID/TNFRSF1A	-0.686173454260313
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/526	139/9376	0.769428563612988	CALM2/GNAI2/JUN/ITPR2/CALM3/HSPA8	-0.667658386135524
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/526	28/9376	0.636610537751222	ELOVL2	-0.469460295723251
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/526	28/9376	0.636610537751222	AKR1B1	-0.469460295723251
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/526	76/9376	0.703622173303982	CD36/PLTP/DBI	-0.632437926120984
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/526	98/9376	0.727554900287111	CALM2/ITPR2/CALM3/PRKCB	-0.660954752448108
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/526	29/9376	0.614658450242559	RASSF4	-0.506658802376253
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/526	99/9376	0.720205860890272	JUN/IGF1/CCND1/RB1	-0.682274762534695
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/526	163/9376	0.765494879749936	JUN/YWHAB/TLR4/PRKCB/BID/EGR2/RB1	-0.736296050986622
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/526	78/9376	0.685580579116701	LSM3/LSM7/C1D	-0.679780603984694
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	5/526	122/9376	0.730536682665337	JUN/CD28/CD4/MAP3K8/LCP2	-0.730334295030813
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	10/526	226/9376	0.788721020222753	CALM2/ATP1B1/ATP1B3/GNAI2/JUN/CALM3/RYR2/ATP2B1/PLD1/ADRB1	-0.783802850473485
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/526	30/9376	0.594169835234474	MDH1	-0.542748882982865
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/526	30/9376	0.594169835234474	FOLR2	-0.542748882982865
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/526	31/9376	0.575003066355943	PGLS	-0.577808419182832
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/526	31/9376	0.575003066355943	ALDH9A1	-0.577808419182832
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/526	31/9376	0.575003066355943	MDH1	-0.577808419182832
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/526	104/9376	0.685580579116701	PLPP3/SGMS1/CEPT1/PLD1	-0.78604280462174
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/526	32/9376	0.557034220532319	AKR1B1	-0.611907288381042
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/526	32/9376	0.557034220532319	LDHB	-0.611907288381042
Human Diseases	Immune disease	hsa05310	Asthma	1/526	32/9376	0.557034220532319	FCER1G	-0.611907288381042
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/526	59/9376	0.60424051040794	GNAI2/ADRB1	-0.743406185396017
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/526	33/9376	0.540154395667704	VAMP8	-0.645108419237213
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/526	150/9376	0.713003802281369	HGF/WNT2/RARB/FZD2/CCND1/RB1	-0.863817349212436
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/526	107/9376	0.666358693720905	CALM2/LDHB/ITPR2/CALM3	-0.84617879059727
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/526	109/9376	0.654131928698504	CD36/PRKCB/SOCS3/TNFRSF1A	-0.88544382691445
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/526	35/9376	0.509288430200978	AKR1B1	-0.70903962855877
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/526	86/9376	0.62180564152445	JUN/AREG/PRKCB	-0.858940913452437
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/526	110/9376	0.648185274801244	GNAI2/IGF1/ANAPC11/CPEB4	-0.904838523633662
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/526	87/9376	0.614658450242559	JUN/AREG/CCND1	-0.880294238623191
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/526	36/9376	0.495141529362062	ENPP1	-0.739868154135996
Genetic Information Processing	Transcription	hsa03040	Spliceosome	10/526	243/9376	0.733543006462314	LSM3/LSM7/HNRNPA1/SNRPC/SF3B6/SF3B5/HSPA8/HNRNPK/SNRPB2/SNRPE	-1.02595994663581
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/526	37/9376	0.48175932586579	NAGK	-0.769997020832312
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/526	38/9376	0.469081448869322	NAGK	-0.79946533793848
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/526	38/9376	0.469081448869322	ENPP1	-0.79946533793848
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/526	38/9376	0.469081448869322	CD4	-0.79946533793848
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	3/526	93/9376	0.575003066355943	ACTB/MYL12A/PTPRJ	-1.00413006493283
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/526	94/9376	0.568886012458539	S100A9/CCL2/JUN	-1.02409945142185
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/526	70/9376	0.509288430200978	HPGDS/SULT1A1	-1.00461733679618
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/526	120/9376	0.594169835234474	CALM2/JUN/CALM3/BEX3	-1.09076237619593
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/526	144/9376	0.618926911702577	WNT2/IGF1/BMP4/ID3/FZD2	-1.12343642979434
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/526	43/9376	0.414537094349633	ALDH9A1	-0.938058349992729
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/526	122/9376	0.58442934613227	CD36/IGF1/CCND1/ADIPOR1	-1.12633327433968
NA	NA	hsa04519	Cadherin signaling	17/526	404/9376	0.750065881112826	WNT2/ARPC3/ACTB/ARPC1B/CDH11/GJA1/YWHAB/ARPC5/PCDH10/PRICKLE1/PCDH12/BRK1/CYFIP1/ACTR2/SCN1B/FZD2/NCKAP1L	-1.25192545935341
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/526	44/9376	0.405115796750778	HMGB1	-0.96422477198698
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/526	73/9376	0.488358768685869	CD4/SERINC5	-1.06984861785631
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/526	47/9376	0.379257341639026	SOCS3	-1.04003953666171
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/526	48/9376	0.371356147021546	ALDH9A1	-1.06448096102745
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/526	154/9376	0.578736852501111	ALAS2/NME2/AKR1A1/NME3/GCLM	-1.28501484458658
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/526	79/9376	0.451268229292006	HPGDS/AKR7A2	-1.19401315318991
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/526	108/9376	0.495141529362062	SUMO2/SAP18/SUMO1	-1.28645733481639
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/526	109/9376	0.490598946523878	JUN/RUNX1/CD4	-1.30409845733048
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/526	82/9376	0.434758416025225	NME2/NME3	-1.25327556338831
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	6/526	184/9376	0.581253099685899	NRP1/SLIT2/MYL12A/GNAI2/EPHA3/UNC5C	-1.39849972038709
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/526	54/9376	0.330094352908041	RPA3	-1.20354641701633
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/526	116/9376	0.460993837681919	PGLS/ESD/MDH1	-1.42404628967242
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	5/526	168/9376	0.530508781459352	IL12RB2/CCND2/SOCS3/PIAS2/CCND1	-1.4969466890187
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/526	57/9376	0.312720965912881	ELOVL2	-1.26879875130593
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	7/526	217/9376	0.575003066355943	GNAI2/JUN/ARRB2/PRKCB/CCND1/RB1/ADRB1	-1.54418208263464
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/526	90/9376	0.396113223489649	IGF1/ADIPOR1	-1.40336069847116
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/526	90/9376	0.396113223489649	ATP1B1/ATP1B3	-1.40336069847116
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/526	59/9376	0.30212025520397	CCND1	-1.31091769771266
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/526	60/9376	0.297084917617237	PRKCB	-1.33159029801529
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/526	62/9376	0.287501533177971	RBPJ	-1.37220354521162
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/526	65/9376	0.27423223164668	ITPR2	-1.43140677030589
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/526	66/9376	0.270077197833852	HSD17B2	-1.45071109675589
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/526	71/9376	0.251057676859637	LDHB	-1.54428066539209
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/526	72/9376	0.247570764681031	TANK	-1.56244210473389
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/526	73/9376	0.244179384342935	HPGDS	-1.58043095731578
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/526	75/9376	0.23766793409379	BID	-1.61590889756785
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/526	78/9376	0.228526859705567	PIK3CG	-1.66793919979252
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/526	83/9376	0.214760181410051	SOD1	-1.75174249932209
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/526	86/9376	0.207268547174817	SCN9A	-1.80042209237809
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	9/526	323/9376	0.496674475273399	MARCKS/ZEB2/FSCN1/CCND2/STMN1/CDK6/PRKCB/HNRNPK/CCND1	-2.24419624245454
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/526	103/9376	0.173059175311012	SAP18	-2.05726288108865
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/526	117/9376	0.152351239803711	ACTB	-2.24922910629946
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/526	370/9376	0.433583393279211	SPX/TSPO/C3AR1/LPAR6/HRH1/KISS1/OGFRL1/CYSLTR1/ADRB1	-2.71005274531619
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/526	183/9376	0.19480978204409	NOP10/RPP25	-2.68165114420641
NA	NA	hsa04382	Cornified envelope formation	2/526	217/9376	0.164286590387412	S100A9/S100A6	-3.03647761002924
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/526	449/9376	0.119098630670607	CALM2/CALM3/ARRB2	-4.66342034568726