category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	76/1050	275/9376	2.46779567099567	C1QA/MT-CO2/MT-ATP6/C1QC/MT-CO3/MT-CYB/MT-ND1/C1QB/MT-ND3/CYBB/MT-ND5/MT-CO1/MT-ND2/CYBA/ITPR2/MT-ND4/NCF4/C7/NDUFA3/PSMC1/ATP5F1B/NDUFS8/ADRM1/NCF2/NDUFS6/NDUFV3/NDUFAB1/PSMA6/NDUFA12/PSMC2/ATP5PD/MT-ND4L/UQCRFS1/NDUFB6/PRNP/BAD/PSMA4/PSMD3/BAX/RYR1/GRIN2C/PRKACA/COX4I2/PSMB4/SDHD/ATP5PB/COX5B/NDUFA2/TUBB/TUBA1B/ATP5PF/NDUFA1/PSMA5/PSMD6/PSMA3/PSMA1/NDUFA4L2/EGR1/RYR2/NDUFB5/MAPK9/NDUFA4/NDUFV2/COX7B/PRKACB/UQCR11/TUBB2A/MAPK14/NDUFB3/NCAM2/COX8A/CREB3L1/APAF1/ATP5MC2/UQCRB/SLC25A5	8.7730272167449
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	47/1050	138/9376	3.04121463077985	MT-CO2/MT-ATP6/MT-CO3/MT-CYB/MT-ND1/MT-ND3/MT-ND5/MT-CO1/MT-ND2/MT-ND4/NDUFA3/ATP5F1B/NDUFS8/NDUFS6/NDUFV3/ATP6V1F/NDUFAB1/ATP6V1A/NDUFA12/ATP6V0A1/ATP5PD/MT-ND4L/UQCRFS1/NDUFB6/COX4I2/SDHD/ATP5PB/COX5B/NDUFA2/ATP6AP1/COX11/ATP5PF/NDUFA1/TCIRG1/ATP6V0D1/NDUFA4L2/NDUFB5/NDUFA4/NDUFV2/COX7B/UQCR11/NDUFB3/COX15/COX8A/ATP5MC2/UQCRB/ATP6V0B	8.5783017967009
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	60/1050	205/9376	2.61351916376307	MT-CO2/MT-ATP6/MT-CO3/MT-CYB/COL3A1/MT-ND1/SLC2A1/MT-ND3/CYBB/MT-ND5/MT-CO1/MT-ND2/CYBA/COL1A1/CD36/MT-ND4/NCF4/NDUFA3/ATP5F1B/NDUFS8/NCF2/NDUFS6/COL1A2/NDUFV3/NDUFAB1/NDUFA12/ATP5PD/MT-ND4L/UQCRFS1/NDUFB6/COX4I2/SDHD/ATP5PB/COX5B/PARP1/NDUFA2/MPC2/GFPT1/TGFB1/ATP5PF/NDUFA1/PDK4/NDUFA4L2/AKT1/RYR2/NDUFB5/MAPK9/NDUFA4/NDUFV2/COX7B/G6PD/UQCR11/MAPK14/NDUFB3/PPP1CB/COX8A/ATP5MC2/UQCRB/SLC25A5/IRS1	8.29477855418497
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	69/1050	268/9376	2.29901918976546	MT-CO2/MT-ATP6/MT-CO3/MT-CYB/MT-ND1/MT-ND3/MT-ND5/MT-CO1/MT-ND2/ITPR2/MT-ND4/NDUFA3/UBE2L3/PSMC1/UBA52/ATP5F1B/NDUFS8/ADRM1/NDUFS6/NDUFV3/NDUFAB1/PSMA6/NDUFA12/PSMC2/ATP5PD/MT-ND4L/UQCRFS1/NDUFB6/PSMA4/PSMD3/BAX/PRKACA/COX4I2/PSMB4/SDHD/ATP5PB/COX5B/XBP1/NDUFA2/TUBB/UBE2J2/TUBA1B/ATP5PF/CALM3/TXN2/NDUFA1/TP53/PSMA5/PSMD6/PSMA3/PSMA1/NDUFA4L2/NDUFB5/MAPK9/NDUFA4/NDUFV2/COX7B/UBA7/PRKACB/UQCR11/TUBB2A/TRAP1/NDUFB3/COX8A/APAF1/ATP5MC2/UQCRB/SLC25A5/MAP3K5	7.66184809319066
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	72/1050	308/9376	2.08742115027829	MT-CO2/MT-ATP6/MT-CO3/MT-CYB/MT-ND1/MT-ND3/MT-ND5/MT-CO1/MT-ND2/MT-ND4/DNAH8/NDUFA3/PSMC1/ATP5F1B/NDUFS8/ADRM1/GPX7/NDUFS6/NDUFV3/NDUFAB1/PSMA6/NDUFA12/PSMC2/ATP5PD/MT-ND4L/UQCRFS1/NDUFB6/PSMA4/PSMD3/BAX/POLR2J/COX4I2/PSMB4/SDHD/ATP5PB/COX5B/POLR2K/NDUFA2/TUBB/POLR2E/TUBA1B/ATP5PF/NDUFA1/TP53/PSMA5/PSMD6/PSMA3/WIPI2/PSMA1/NDUFA4L2/NRBF2/DCTN5/GRIA4/NDUFB5/MAPK9/NDUFA4/NDUFV2/COX7B/UQCR11/TUBB2A/NDUFB3/COX8A/CREB3L1/APAF1/AP2S1/ATP5MC2/UQCRB/WIPI1/DNALI1/SLC25A5/MAP3K5/BDNF	6.89095577560902
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	57/1050	227/9376	2.24221522970422	MT-CO2/MT-ATP6/MT-CO3/MT-CYB/MT-ND1/MT-ND3/MT-ND5/MT-CO1/MT-ND2/HGF/CYBA/MT-ND4/NDUFA3/ATP5F1B/NDUFS8/PTPRJ/AKR1A1/NCF2/NDUFS6/NDUFV3/NDUFAB1/NDUFA12/ATP5PD/MT-ND4L/UQCRFS1/NDUFB6/BAD/COX4I2/SDHD/ATP5PB/COX5B/MAP2K2/NDUFA2/ATP5PF/NDUFA1/NDUFA4L2/AKT1/NDUFB5/MAPK9/ARNT/NDUFA4/NDUFV2/COX7B/UQCR11/MAPK14/GSTA4/NDUFB3/COX8A/PDPK1/ACP1/GRB2/SLC26A2/ATP5MC2/UQCRB/SLC25A5/IKBKG/MAP3K5	6.72798552932059
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	80/1050	368/9376	1.94120082815735	MT-CO2/MT-ATP6/MT-CO3/MT-CYB/MT-ND1/MT-ND3/MT-ND5/MT-CO1/MT-ND2/MT-ND4/ACTB/DNAH8/NDUFA3/PSMC1/ATP5F1B/NDUFS8/ADRM1/GPX7/NDUFS6/NDUFV3/NDUFAB1/PSMA6/NDUFA12/PSMC2/ATP5PD/MT-ND4L/UQCRFS1/NDUFB6/BAD/PSMA4/PSMD3/BAX/CCS/GRIN2C/COX4I2/PSMB4/SDHD/NUP54/ATP5PB/COX5B/XBP1/NDUFA2/TUBB/TUBA1B/ATP5PF/NDUFA1/TP53/PSMA5/NUP214/PSMD6/PSMA3/WIPI2/PSMA1/NDUFA4L2/ANXA11/NRBF2/DCTN5/NDUFB5/NUP62/NDUFA4/NDUFV2/COX7B/FIG4/CHCHD10/UQCR11/NDC1/TUBB2A/TOMM40/MAPK14/NDUFB3/SRSF3/COX8A/NUP37/NUP133/APAF1/ATP5MC2/UQCRB/WIPI1/DNALI1/MAP3K5	6.54114995937123
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	57/1050	235/9376	2.16588449848024	MT-CO2/MT-ATP6/MT-CO3/MT-CYB/MT-ND1/MT-ND3/MT-ND5/MT-CO1/MT-ND2/MT-ND4/ACTB/NDUFA3/ATP5F1B/NDUFS8/NDUFS6/NDUFV3/SMARCB1/NDUFAB1/NDUFA12/ATP5PD/MT-ND4L/UQCRFS1/NDUFB6/COX14/PRKACA/COX4I2/SDHD/NDUFAF8/ATP5PB/COX5B/NDUFA2/COX11/COX16/ATP5PF/PRDM16/NDUFA1/COA5/NDUFA4L2/NDUFB5/NDUFA4/NDUFV2/COX7B/PRKACB/UQCR11/SLC25A20/MAPK14/SMARCD2/NDUFB3/COX15/NDUFAF6/COX8A/TSC2/GRB2/CREB3L1/ATP5MC2/UQCRB/MAP3K5	6.42768653723764
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	78/1050	388/9376	1.79511045655376	MT-CO2/MT-ATP6/MT-CO3/MT-CYB/MT-ND1/MT-ND3/CYBB/MT-ND5/APOE/MT-CO1/MT-ND2/ITPR2/WNT2/MT-ND4/NDUFA3/PSMC1/ATP5F1B/NDUFS8/ADRM1/NDUFS6/NDUFV3/NDUFAB1/PSMA6/LRP1/NDUFA12/PSMC2/ATP5PD/MT-ND4L/UQCRFS1/NDUFB6/BAD/PSMA4/PSMD3/GRIN2C/COX4I2/PSMB4/SDHD/ATP5PB/COX5B/LRP6/MAP2K2/XBP1/NDUFA2/TUBB/APH1A/TUBA1B/ATP5PF/CALM3/NDUFA1/PSMA5/PSMD6/PSMA3/WIPI2/FZD2/PSMA1/NDUFA4L2/AKT1/NRBF2/NDUFB5/MAPK9/NDUFA4/NDUFV2/COX7B/FZD4/UQCR11/TUBB2A/NDUFB3/COX8A/APAF1/NCSTN/ATP5MC2/UQCRB/WIPI1/DVL3/SLC25A5/IRS1/IKBKG/MAP3K5	5.68033409962112
Genetic Information Processing	Translation	hsa03010	Ribosome	51/1050	222/9376	2.05137709137709	RPL27A/RPL23/RPLP1/RPS11/RPL23A/RPL38/RPL13A/MRPL27/UBA52/MRPL54/RPL21/RPS23/MRPL14/MRPS18C/MRPL51/RPLP2/RPS24/RPL27/MRPS7/MRPS18B/MRPS16/RPS2/RPS14/MRPS14/RPS20/MRPS34/MRPL9/RPL14/MRPS33/MRPL36/RPL28/MRPL15/RPL26L1/RPL22L1/MRPL20/MRPL17/MRPL4/MRPS35/RPL35/MRPS26/MRPL48/MRPL3/RPS16/MRPL12/MRPS23/MRPL10/RPL18/RPL15/RPL19/MRPS22/MRPL23	5.62978263989872
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	90/1050	480/9376	1.67428571428571	MT-CO2/MT-ATP6/MT-CO3/MT-CYB/MT-ND1/MT-ND3/CYBB/MT-ND5/MT-CO1/MT-ND2/ITPR2/WNT2/MT-ND4/DNAH8/NDUFA3/UBE2L3/PSMC1/UBA52/ATP5F1B/NDUFS8/ADRM1/GPX7/NDUFS6/NDUFV3/NDUFAB1/PSMA6/NDUFA12/PSMC2/ATP5PD/MT-ND4L/UQCRFS1/NDUFB6/PRNP/BAD/PSMA4/PSMD3/BAX/RYR1/CCS/GRIN2C/COX4I2/PSMB4/SDHD/ATP5PB/COX5B/LRP6/MAP2K2/XBP1/NDUFA2/TUBB/UBE2J2/TUBA1B/ATP5PF/CALM3/NDUFA1/PSMA5/PSMD6/PSMA3/WIPI2/FZD2/PSMA1/NDUFA4L2/RYR2/NRBF2/DCTN5/GRIA4/NDUFB5/MAPK9/NDUFA4/NDUFV2/COX7B/UBA7/FIG4/FZD4/UQCR11/TUBB2A/TRAP1/TOMM40/MAPK14/NDUFB3/COX8A/APAF1/ATP5MC2/UQCRB/WIPI1/DNALI1/DVL3/SLC25A5/MAP3K5/BDNF	5.38554023283435
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	38/1050	157/9376	2.16128601759175	MT-CO2/MT-CO3/MT-CYB/MT-CO1/CXCL8/NDUFA3/NDUFS8/NDUFS6/NDUFV3/NDUFAB1/NDUFA12/UQCRFS1/NDUFB6/BAX/COX4I2/SDHD/COX5B/XBP1/NDUFA2/TGFB1/CEBPA/NDUFA1/NDUFA4L2/AKT1/NDUFB5/MAPK9/NDUFA4/NDUFV2/COX7B/UQCR11/MAPK14/NDUFB3/COX8A/ADIPOR1/UQCRB/IRS1/SREBF1/MAP3K5	5.21085754027205
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	51/1050	250/9376	1.82162285714286	LGMN/CTSC/VAMP8/CD68/TPP1/LAMTOR4/ATP6V1F/LAMTOR2/ATP6V1A/ATP6V0A1/LIPA/LAMTOR5/BLOC1S1/VPS29/ATP6AP1/M6PR/BLOC1S5/AP1M1/TCIRG1/BLOC1S2/NAGLU/HEXA/ATP6V0D1/WDR7/FUCA2/TLR7/DMXL1/GNPTAB/PPT1/CLN6/ASAH1/AP3M1/FIG4/DMXL2/CTSB/LAMTOR1/NPC2/HYAL4/CLCN7/BORCS5/TELO2/FUCA1/CTNS/AP2S1/VAMP7/LAMTOR3/MFSD8/NEU1/SMPD1/GALNS/ATP6V0B	4.67589089720047
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	48/1050	238/9376	1.80091236494598	F13A1/C1QA/C1QC/C1QB/CYBB/RPL27A/FCGR2A/RPL23/MMP1/RPLP1/NRP1/CXCL8/C7/C3AR1/SYK/CCL2/RPS11/C2/RPL23A/RPL38/RPL13A/UBA52/RPL21/RPS23/RPLP2/RPS24/RPL27/RPS2/CFD/RPS14/RPS20/RPL14/RPL28/RPL26L1/RPL22L1/NLRP3/TLR2/TLR7/RPL35/MAPK9/RPS16/MYD88/MAPK14/RPL18/RPL15/IRAK1/RPL19/IKBKG	4.44436772135633
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	33/1050	149/9376	1.97767976989453	GNGT1/MT-ND1/MT-ND3/MT-ND5/MT-ND2/ITPR2/MT-ND4/GNG2/NDUFA3/GABRA3/NDUFS8/NDUFS6/NDUFV3/NDUFAB1/NDUFA12/MT-ND4L/NDUFB6/PRKACA/NDUFA2/KCNJ5/NDUFA1/NDUFA4L2/GRIA4/NDUFB5/MAPK9/GABRA2/NDUFA4/NDUFV2/GNB2/PRKACB/MAPK14/NDUFB3/GNG7	4.27190501071
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	14/1050	50/9376	2.50026666666667	HBA2/HBA1/HBB/HGF/CR1/CD36/CXCL8/CCL2/ITGB2/LRP1/TGFB1/GYPB/TLR2/MYD88	3.77718138912474
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	31/1050	155/9376	1.78590476190476	CD14/FCGR2B/CYBB/FCGR3A/CYBA/FCGR2A/CD36/ACTB/FCGR1A/SCARB1/NCF4/CLEC7A/ITGB2/NCF2/ATP6V1F/CORO1A/ATP6V1A/ATP6V0A1/STX7/CD209/ITGAM/ATP6AP1/TUBB/TUBA1B/M6PR/TCIRG1/ATP6V0D1/TLR2/TUBB2A/SEC22B/ATP6V0B	3.50355421892052
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	14/1050	51/9376	2.45124183006536	ACTB/KDELR2/ATP6V1F/ATP6V1A/ATP6V0A1/KCNQ1/PRKACA/ATP6AP1/ERO1A/TCIRG1/ATP6V0D1/KDELR3/PRKACB/ATP6V0B	3.69030736618787
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	34/1050	181/9376	1.67736911339121	CD14/FCGR2B/FCER1G/FCGR3A/CR1/FCGR2A/FCGR1A/CLEC7A/SYK/ITGB2/CORO1A/IFNGR2/ATP6V0A1/CD209/TLR1/BAD/ITGAM/BAX/ATP6AP1/TGFB1/CALM3/TCIRG1/ATP6V0D1/TLR2/AKT1/MAPK9/IFNGR1/IL10RB/MYD88/MAPK14/IL10RA/IRAK1/APAF1/ATP6V0B	3.26776558749665
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	12/1050	46/9376	2.32944099378882	PSMC1/ADRM1/PSMA6/PSMC2/PSMA4/PSMD3/PSMB4/PSMA5/PSMD6/PSMA3/PSMA1/PSMB10	3.20973549328221
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	17/1050	78/9376	1.94617826617827	LSM8/CNOT7/LSM7/C1D/LSM3/LSM5/EXOSC7/MPHOSPH6/EXOSC8/EXOSC6/DCP2/CNOT2/LSM6/EXOSC2/BTG2/PABPC4L/EXOSC4	2.97980320487119
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	17/1050	78/9376	1.94617826617827	CYBB/FCGR3A/CYBA/CR1/FCGR2A/FCGR1A/NCF4/ITGB2/NCF2/IFNGR2/ITGAM/TGFB1/TLR2/IFNGR1/MYD88/MAPK14/IRAK1	2.97980320487119
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	20/1050	98/9376	1.822351797862	FCGR2B/FCGR3A/FCGR2A/PTPRC/FCGR1A/SYK/SCIN/HCK/VAV1/WAS/ARF6/ARPC5/AKT1/INPP5D/LYN/INPPL1/ARPC2/VASP/LIMK1/BIN1	2.90606674316165
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	31/1050	174/9376	1.59089217296114	SSR3/DNAJB11/SSR1/LMAN2/DNAJC10/SAR1B/DERL2/DNAJA2/BAX/UBXN6/ERP29/XBP1/UBE2J2/STT3A/ERO1A/PLAA/TRAM1/OSTC/NSFL1C/MAPK9/EDEM1/MAN1B1/SEC23B/MOGS/AMFR/UBE2D4/HERPUD1/DNAJB2/PREB/RPN2/MAP3K5	2.79385479918048
NA	NA	hsa04517	IgSF CAM signaling	48/1050	299/9376	1.43350215002389	SLIT2/ACTB/PTPRD/CADM3/NRP1/CD28/MTSS1/GRIP2/CD86/ITGB2/LCP2/IL1RAPL1/WASL/JAM2/CD209/JAM3/ROBO2/ITGAM/SCN8A/CDH2/CD84/MAP2K2/TUBB/DOK2/VAV1/TUBA1B/LRRTM4/ARF6/LRFN5/CLMP/ARPC5/ANK3/AKT1/INPP5D/MAPK9/SLAMF1/EZR/DYNLL2/LYN/TUBB2A/MAPK14/ARPC2/NCAM2/NLGN4X/PDPK1/CASKIN2/GRB2/CNTNAP2	2.70531453989806
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	11/1050	44/9376	2.23238095238095	STT3A/MGAT4B/OSTC/HEXA/MAN1B1/ALG14/MGAT2/ALG3/RPN2/HEXD/ALG1	2.90968540012196
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	19/1050	95/9376	1.78590476190476	CCL3/ANGPT1/CCL3L1/MMP1/CD28/CXCL8/CCL2/CD86/ITGB2/ATP6V1F/ATP6V1A/ATP6V0A1/ATP6AP1/TGFB1/CXCL12/TCIRG1/ATP6V0D1/TLR2/ATP6V0B	2.73398684775274
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	36/1050	216/9376	1.48825396825397	CD14/CCL3/CYBB/CYBA/CD36/ABCA1/CCL3L1/MMP1/NCF4/CXCL8/CCL2/NCF2/POU2F2/BAD/BAX/TNFSF10/XBP1/ERO1A/VAV1/CALM3/TP53/NLRP3/TLR2/AKT1/MAPK9/LYN/MYD88/MIB1/MAPK14/IRAK1/PDPK1/APAF1/IKBKG/HSPA2/MAP3K5/LY96	2.57802428965543
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	25/1050	138/9376	1.61766735679779	FN1/FCGR2A/ACTB/CXCL8/FYB1/CCL2/CD4/LCP2/WASL/MAP2K2/RHOG/VAV1/WAS/ARF6/NLRP3/ARPC5/AKT1/MAPK9/PKN1/MYD88/MAPK14/ARPC2/IRAK1/LIMK1/IKBKG	2.59577651300573
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	12/1050	52/9376	2.06065934065934	PLTP/APOE/CD36/ABCA1/APOC1/SCARB1/LRP1/LIPA/STARD3NL/MYLIP/TSPO/NPC2	2.72357001862322
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	16/1050	78/9376	1.83169719169719	C1QA/CD14/C1QC/C1QB/CXCL8/C2/C4BPB/ITGB2/ITGAM/CALM3/NLRP3/MAPK9/MYD88/MAPK14/IRAK1/LY96	2.61926747410063
Organismal Systems	Immune system	hsa04611	Platelet activation	23/1050	126/9376	1.62999244142101	COL3A1/FCER1G/ITPR2/FCGR2A/VAMP8/COL1A1/ACTB/P2RY1/SYK/TBXAS1/LCP2/COL1A2/PRKACA/FERMT3/AKT1/ORAI1/LYN/PRKACB/MAPK14/GNA13/VASP/PPP1CB/APBB1IP	2.52820234325784
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	40/1050	250/9376	1.42872380952381	DAB2/FOLR2/PSD3/CYTH4/WASL/VPS4B/SNF8/GRK3/CHMP1B/CAPZB/ZFYVE16/WASHC3/VPS29/FGFR3/CHMP5/SH3GLB2/VPS37A/WASHC4/SNX5/ARF4/MVB12A/STAM/ARF6/CAPZA1/ARPC5/VTA1/PDGFRA/RBSN/CAPZA2/ARPC2/ACAP2/AP2S1/GRK6/SNX4/BIN1/MVB12B/ARRB2/VPS25/FGFR2/RAB11FIP2	2.43988557637818
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	10/1050	42/9376	2.12607709750567	IDO2/IDO1/AOC1/DLD/ALDH7A1/GCDH/HAAO/KYNU/AFMID/ALDH1B1	2.59729307227626
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	25/1050	144/9376	1.55026455026455	RBPJ/ITPR2/PSMC1/ADRM1/PSMA6/PSMC2/PSMA4/PSMD3/RYR1/GRIN2C/PSMB4/XBP1/PSMA5/PSMD6/CIC/PSMA3/WIPI2/PSMA1/AKT1/NRBF2/MAPK9/GTF2B/WIPI1/SLC25A5/MAP3K5	2.36301766209364
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	14/1050	68/9376	1.83843137254902	CD14/CSF1R/FCGR1A/SPI1/RUNX1/BAD/ITGAM/MAP2K2/CEBPA/AKT1/BCL2A1/PIM1/GRB2/IKBKG	2.46408607211768
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	20/1050	109/9376	1.63844473569244	SPP1/CD14/CCL3/CCL4/CCL4L2/CCL3L1/CXCL8/CD86/TLR1/MAP2K2/TLR2/AKT1/TLR7/MAPK9/IRF5/MYD88/MAPK14/IRAK1/IKBKG/LY96	2.38083370566885
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	15/1050	75/9376	1.78590476190476	BAD/BAX/XIAP/MSH6/TP53/AKT1/XPA/GSTP1/GSTA4/TOP2A/PDPK1/APAF1/ATM/ATP7A/MAP3K5	2.42659788200243
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	8/1050	31/9376	2.30439324116743	SRP19/SRP9/SPCS2/SPCS3/OXA1L/SEC11C/SGTA/SPCS1	2.58322252123314
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	13/1050	62/9376	1.87231950844854	RBPJ/JAG1/HEY1/MAML2/APH1A/MFNG/NOTCH3/CIR1/DLL4/TLE3/NCSTN/DVL3/CTBP1	2.44717708599788
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/1050	10/9376	3.57180952380952	PAPSS2/PAPSS1/TST/SELENBP1	2.88950737974434
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	14/1050	69/9376	1.81178743961353	FCER1G/SYK/LCP2/MAP2K2/VAV1/ALOX5/ALOX5AP/AKT1/INPP5D/MAPK9/LYN/MAPK14/PDPK1/GRB2	2.4033891723809
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1050	21/9376	2.5512925170068	ENPP1/VNN2/PPCS/AASDHPPT/ALDH1B1/PPCDC	2.52722281441147
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14/1050	71/9376	1.76075117370892	CXCL8/ATP6V1F/JAM2/ATP6V1A/ATP6V0A1/JAM3/ATP6AP1/TCIRG1/ATP6V0D1/MAPK9/LYN/MAPK14/IKBKG/ATP6V0B	2.28494473880927
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	24/1050	142/9376	1.5092152917505	FCGR2B/TYROBP/FCGR3A/CYBA/ITPR2/FCGR2A/CSF1R/FCGR1A/NCF4/SYK/SPI1/LCP2/LILRB5/NCF2/IFNGR2/TGFB1/AKT1/MAPK9/IFNGR1/MAPK14/GRB2/LILRB3/IKBKG/BLNK	2.17126463426057
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	38/1050	248/9376	1.36823348694316	CD14/ACTB/PTPRC/CXCL8/CYTH4/ARHGEF26/NCKAP1L/WASL/CSE1L/BAX/RRAS/MAP2K2/TNFSF10/RHOG/TUBB/TUBA1B/M6PR/TXN2/ARF6/NLRP3/ARPC5/TAB3/TLR2/AKT1/CYFIP1/PIK3C2B/DCTN5/MAPK9/PKN1/DYNLL2/MYD88/TUBB2A/SNX18/MAPK14/ARPC2/IRAK1/IKBKG/LY96	2.08700451985318
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	24/1050	144/9376	1.48825396825397	C1QA/CD14/C1QC/C1QB/CXCL8/C3AR1/C2/IL17RA/TAB3/ALDH7A1/ADH5/AKT1/MAPK9/MYD88/MAPK14/SCD5/IRAK1/ADIPOR1/SIRT1/ALDH1B1/IKBKG/SREBF1/MAP3K5/LY96	2.09672374863463
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	23/1050	137/9376	1.49911713590546	CTSC/ITPR2/ACTB/BAD/BAX/MAP2K2/PARP1/TNFSF10/XIAP/TUBA1B/TP53/AKT1/BCL2A1/MAPK9/CTSB/PARP2/PDPK1/APAF1/ATM/ENDOG/LMNB1/IKBKG/MAP3K5	2.08983676428122
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/1050	101/9376	1.59140028288543	COL3A1/CYBB/FN1/COL1A1/CXCL8/F3/CCL2/COL4A1/COL1A2/VEGFB/BAX/TGFB1/COL4A2/AKT1/EGR1/MAPK9/MAPK14/PIM1	2.12200957952873
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	16/1050	88/9376	1.62354978354978	F13A1/C1QA/C1QC/C1QB/SERPINE2/CR1/VSIG4/C7/C3AR1/F3/C2/C4BPB/ITGB2/CFD/VTN/ITGAM	2.08695675536977
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	18/1050	103/9376	1.56049930651872	C1QA/CCL3/C1QC/C1QB/CCL3L1/CXCL8/CCL2/IFNGR2/TGFB1/TLR2/AKT1/MAPK9/IFNGR1/MYD88/MAPK14/PPP2R2A/IRAK1/IKBKG	2.03116706780914
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	4/1050	12/9376	2.97650793650794	FCGR2B/CD209/SLAMF1/NCAM2	2.43287932397083
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	30/1050	193/9376	1.3880088823094	CXCL14/CCL3/GNGT1/CCL4/CCL4L2/CCL3L1/GNG2/CXCL8/CCL2/CCR1/DOCK2/CCL8/HCK/BAD/GRK3/PRKACA/VAV1/WAS/CXCL12/AKT1/CX3CR1/GNB2/LYN/PRKACB/PREX1/GNG7/GRB2/GRK6/IKBKG/ARRB2	1.93414983212863
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	19/1050	112/9376	1.51482993197279	LAMA2/IFNGR2/BAD/XIAP/TGFB1/ALOX5/LAMC3/TLR2/AKT1/MAPK9/IFNGR1/IL10RB/MYD88/MAPK14/IL10RA/IRAK1/PDPK1/IKBKG/LY96	1.94641575488033
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	18/1050	105/9376	1.53077551020408	CD14/CCL4/CCL4L2/CXCL8/SYK/EDA/PARP1/XIAP/CXCL12/TAB3/BCL2A1/LYN/MYD88/IRAK1/ATM/IKBKG/LY96/BLNK	1.9422463766107
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	5/1050	18/9376	2.48042328042328	HEXA/FUCA2/FUCA1/NEU1/HEXD	2.23250645138926
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	51/1050	362/9376	1.25802683504341	SPP1/LAMA2/GNGT1/FN1/IGF2/HGF/CSH1/ANGPT1/COL1A1/CSF1R/PRLR/GNG2/SYK/COL4A1/AREG/KITLG/PDGFC/CDK6/COL1A2/PIK3AP1/VEGFB/VTN/EIF4E2/BAD/LPAR6/FGFR3/MAP2K2/TP53/COL4A2/LAMC3/PDGFRA/TLR2/AKT1/FGF10/PKN1/LPAR5/GNB2/FGF7/PDGFRB/PPP2R2A/CSH2/GNG7/ITGA3/TSC2/PDPK1/GRB2/CREB3L1/IRS1/IKBKG/BDNF/FGFR2	1.77796197368109
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/1050	31/9376	2.01634408602151	TKT/TALDO1/RPE/PGLS/G6PD/DERA/RPIA	2.01276950038708
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	21/1050	130/9376	1.44246153846154	GNGT1/COL3A1/COL1A1/MMP1/GNG2/COL4A1/COL1A2/VEGFB/PRKACA/MAP2K2/TGFB1/COL4A2/AKT1/MAPK9/GNB2/PRKACB/MAPK14/GNG7/GRB2/CREB3L1/ARRB2	1.8039825867722
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	18/1050	108/9376	1.48825396825397	CSE1L/IPO9/MAGOH/NUP54/NUP214/SAP18/PHAX/KPNA2/NMD3/THOC2/NUP62/TMEM33/NUP42/NDC1/MAGOHB/NUP37/NUP133/THOC6	1.81228598249156
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	19/1050	116/9376	1.46259441707718	CYBB/CYBA/ACTB/NCF4/OCLN/ITGB2/CLDN11/NCF2/JAM2/JAM3/ITGAM/VAV1/CXCL12/EZR/SIPA1/MAPK14/VASP/CDH5/TXK	1.78027040736824
NA	NA	hsa04518	Integrin signaling	24/1050	154/9376	1.39161410018553	SPP1/LAMA2/FN1/HGF/COL1A1/ACTB/FREM1/COL4A1/ITGB2/FRAS1/PDGFC/COL1A2/VEGFB/VTN/ITGAM/TGFB1/FERMT3/COL4A2/LAMC3/PDGFRA/AKT1/PDGFRB/ITGA3/ARHGEF6	1.74007595673492
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	22/1050	140/9376	1.40321088435374	SPP1/GNGT1/ITPR2/PDE3B/GNG2/APLNR/JAG1/SLC8A1/APLN/RYR1/RRAS/PRKACA/MAP2K2/CALM3/AKT1/EGR1/RYR2/GNB2/PRKACB/NOTCH3/GNA13/GNG7	1.70693265626669
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/1050	103/9376	1.47380490060102	CD14/LAMA2/COL3A1/FN1/COL1A1/CXCL8/COL4A1/ITGB2/COL1A2/ITGAM/PRKACA/TGFB1/COL4A2/LAMC3/TLR2/PRKACB/SERPINB6	1.71699928880326
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	9/1050	46/9376	1.74708074534162	FTL/FTH1/ALAS2/UROD/BLVRB/UROS/BLVRA/ALAS1/COX15	1.80371418955328
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	22/1050	142/9376	1.38344735077129	UBE2L3/UBA52/ANAPC11/UBE2M/RNF7/UBE2S/UBE2A/UBA3/XIAP/UBE2J2/ANAPC13/UBE2F/PRPF19/ANAPC15/KLHL9/UBA7/UBE2E3/ELOB/UBE2D4/PPIL2/PIAS2/ERCC8	1.6349973877818
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	30/1050	204/9376	1.31316526610644	GPC3/FN1/DCN/IGF2/HGF/ITPR2/WNT2/COL1A1/LUM/ACTB/TWIST1/COL1A2/VTN/RRAS/PRKACA/MAP2K2/TGFB1/VAV1/TP53/FZD2/TLR2/ANK3/AKT1/EZR/PRKACB/FZD4/MAPK14/PPP1CB/PDPK1/GRB2	1.60590086703671
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	31/1050	212/9376	1.30573225516622	HGF/ANGPT1/CSF1R/ACTB/P2RY1/FYB1/ITGB2/LCP2/KITLG/PDGFC/VEGFB/SIPA1L2/ITGAM/RRAS/FGFR3/MAP2K2/VAV1/CALM3/PDGFRA/AKT1/FGF10/FPR1/LPAR5/FGF7/MAGI3/SIPA1/PDGFRB/MAPK14/VASP/APBB1IP/FGFR2	1.59892736171391
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	42/1050	300/9376	1.25013333333333	CD14/IGF2/HGF/ANGPT1/CSF1R/AREG/KITLG/PDGFC/MECOM/VEGFB/RRAS/PRKACA/FGFR3/DUSP3/MAP2K2/DUSP9/TGFB1/PPM1A/TP53/PDGFRA/AKT1/MAPKAPK5/FGF10/MAPK9/FGF7/PRKACB/MYD88/TAOK2/PDGFRB/MAPK14/RPS6KA5/MAP4K2/IRAK1/GRB2/LAMTOR3/TAOK3/IKBKG/MKNK1/MAP3K5/ARRB2/BDNF/FGFR2	1.5636769663531
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	15/1050	91/9376	1.47189952904239	FCGR2B/SYK/LILRB5/PIK3AP1/MAP2K2/VAV1/AKT1/INPP5D/LYN/INPPL1/BANK1/GRB2/LILRB3/IKBKG/BLNK	1.60635441216199
Human Diseases	Substance dependence	hsa05032	Morphine addiction	15/1050	91/9376	1.47189952904239	GNGT1/PDE3B/GNG2/PDE1C/GABRA3/GRK3/PRKACA/KCNJ5/PDE4A/GABRA2/GNB2/PRKACB/GNG7/GRK6/ARRB2	1.60635441216199
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	6/1050	28/9376	1.9134693877551	ATP6V1F/ATP6V1A/ATP6V0A1/TCIRG1/ATP6V0D1/SLC4A1	1.71899948311095
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	33/1050	232/9376	1.27014778325123	TMSB4X/FN1/ACTB/C7/ITGB2/PDGFC/NCKAP1L/WASL/SCIN/IQGAP2/ITGAM/RRAS/FGFR3/MAP2K2/VAV1/CXCL12/ARPC5/PDGFRA/AKT1/CYFIP1/FGF10/EZR/LPAR5/ABI2/FGF7/PDGFRB/GNA13/ARPC2/PPP1CB/ITGA3/ARHGEF6/LIMK1/FGFR2	1.47958314876825
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	10/1050	56/9376	1.59455782312925	STT3A/MGAT4B/OSTC/MAN1B1/MOGS/ALG14/MGAT2/ALG3/RPN2/ALG1	1.58468241874086
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	10/1050	56/9376	1.59455782312925	CD14/CR1/CXCL8/ITGB2/SAR1B/ITGAM/TLR2/MYD88/SEC22B/APAF1	1.58468241874086
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1050	22/9376	2.02943722943723	HNMT/AOC1/CNDP2/ALDH7A1/ALDH1B1	1.71662175647523
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	15/1050	93/9376	1.44024577572965	LAMA2/FN1/COL4A1/CDK6/BAX/XIAP/CKS2/TP53/COL4A2/LAMC3/AKT1/RARB/ITGA3/APAF1/IKBKG	1.51514633973328
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	19/1050	125/9376	1.35728761904762	FCER1G/ORMDL1/BAX/MAP2K2/SPTSSA/TP53/CERS2/SGPP1/AKT1/MAPK9/SGPL1/ASAH1/MAPK14/PPP2R2A/GNA13/S1PR4/PDPK1/SMPD1/MAP3K5	1.4280411348358
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	14/1050	87/9376	1.43693486590038	MT-CO2/MT-CO3/MT-CYB/MT-CO1/ATP1B1/SLC8A1/UQCRFS1/COX4I2/COX5B/RYR2/COX7B/UQCR11/COX8A/UQCRB	1.45396492756079
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/1050	103/9376	1.38711049468331	COL3A1/COL15A1/SLC16A10/COL1A1/COL14A1/ATP1B1/COL11A1/COL4A1/SLC8A1/COL1A2/KCNQ1/COL21A1/COL4A2/COL8A2/KCNE3/COL5A1	1.40283150979738
Human Diseases	Cancer: specific types	hsa05218	Melanoma	12/1050	73/9376	1.46786692759295	HGF/PDGFC/CDK6/BAD/BAX/MAP2K2/TP53/PDGFRA/AKT1/FGF10/FGF7/PDGFRB	1.42506394095548
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/1050	30/9376	1.78590476190476	IDH3G/SDHD/SUCLG2/DLD/FH/SUCLA2	1.53101605061123
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/1050	30/9376	1.78590476190476	FOLR2/ATIC/MTHFR/SLC46A1/ABCC5/IKBKG	1.53101605061123
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	16/1050	105/9376	1.36068934240363	UBA52/TOMM20/NBR1/RRAS/FKBP8/TP53/TAX1BP1/USP15/MAPK9/RHOT1/AMFR/TOMM40/TOMM7/GABARAP/MTX3/MON1A	1.31985661526883
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	23/1050	160/9376	1.28361904761905	PTPRD/PTPRC/NTNG1/CADM3/CD28/OCLN/CD86/CD4/ITGB2/SIGLEC1/CLDN11/VCAN/JAM2/CD276/JAM3/ITGAM/CD58/CDH2/VSIR/NCAM2/NLGN4X/CDH5/CNTNAP2	1.28495002477478
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	28/1050	200/9376	1.25013333333333	FCGR2A/ACTB/CXCL8/OCLN/CYTH4/CLDN11/NCKAP1L/WASL/BAX/TNFSF10/TUBB/TUBA1B/ARF6/NLRP3/ARPC5/TAB3/CYFIP1/MAPK9/EZR/LPAR5/MYD88/MYO1F/TUBB2A/MAPK14/GNA13/ARPC2/IRAK1/IKBKG	1.26976090253881
NA	NA	hsa04981	Folate transport and metabolism	6/1050	31/9376	1.72829493087558	FOLR2/SLCO2B1/MTHFR/SLC46A1/ABCC5/FOLH1	1.44231647954103
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	16/1050	106/9376	1.34785265049416	FOLR2/PDGFC/BAD/MAP2K2/TP53/PDGFRA/AKT1/GSTP1/SLC46A1/PDGFRB/FOLH1/PDPK1/GRB2/CREB3L1/IKBKG/FGFR2	1.27899977144573
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	18/1050	122/9376	1.31747072599532	SLC2A1/SLC16A10/ACTB/ATP1B1/GATA4/BAD/MED4/PRKACA/MAP2K2/TP53/DIO3/AKT1/PRKACB/MED16/SLC16A2/NOTCH3/TSC2/PDPK1	1.25337473854482
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	20/1050	138/9376	1.29413388543823	PDE3B/EIF4E2/BAD/PRKACA/MAP2K2/CALM3/AKT1/PRKAR2B/MAPK9/PRKACB/PHKG2/INPPL1/PPP1CB/PHKA2/TSC2/PDPK1/GRB2/IRS1/SREBF1/MKNK1	1.23611167580228
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	25/1050	178/9376	1.25414660246121	WNT2/RSPO3/RSPO2/VANGL2/SERPINF1/NOTUM/PRKACA/LRP6/BAMBI/TP53/ROR1/RUVBL1/FZD2/ZNRF3/MAPK9/CXXC4/PRKACB/FRZB/FZD4/CTNNBIP1/TLE3/LGR4/SIRT1/DVL3/CTBP1	1.21565318212232
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	15/1050	99/9376	1.35295815295815	C1QA/C1QC/C1QB/FCGR2B/FCGR3A/FCGR2A/FCGR1A/C3AR1/C2/ITGB2/CFD/ITGAM/KRT19/FPR1/KRT23	1.25371586477324
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	15/1050	99/9376	1.35295815295815	PDGFC/SLC22A3/MAP2K2/CHKB/WAS/PDGFRA/DGKB/AKT1/MAPK9/DGKZ/PDGFRB/TSC2/PDPK1/GRB2/SLC44A1	1.25371586477324
Genetic Information Processing	Transcription	hsa03040	Spliceosome	33/1050	243/9376	1.21265138154027	SF3B5/SF3B6/PUF60/LSM8/SRSF1/SNRPF/LSM7/CWC15/SNRPG/MAGOH/SNRPD3/WBP11/U2AF2/SNRPE/LSM3/CDC40/LSM5/SRSF6/SNRPC/CHERP/PRPF19/AQR/SNRNP200/CRNKL1/THOC2/PRPF31/LSM6/SRSF9/MAGOHB/SRSF3/PPIL1/U2AF1/THOC6	1.19268759159064
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/1050	100/9376	1.33942857142857	CXCL14/CCL3/CCL4/CCL4L2/CSF1R/CCL3L1/CXCL8/CCL2/CCR1/CCL8/TNFSF10/CXCL12/CX3CR1/IL10RB/IL10RA	1.21179766345833
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	12/1050	77/9376	1.39161410018553	RUNX1/CDK6/MECOM/BAD/BAX/MAP2K2/TGFB1/TP53/AKT1/GRB2/CTBP1/IKBKG	1.22531469935132
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	8/1050	47/9376	1.51991894630193	GRHPR/AKR1A1/DLD/ALDH7A1/ADH5/FH/HAGH/ALDH1B1	1.26890500584462
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	14/1050	93/9376	1.344229390681	RBPJ/IL12RB2/CD4/JAG1/IFNGR2/MAF/MAML2/STAT6/MAPK9/IFNGR1/MAPK14/NOTCH3/DLL4/IKBKG	1.18469711709222
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/1050	70/9376	1.40321088435374	SLC2A1/HGF/EPAS1/BAD/MAP2K2/TGFB1/AKT1/FH/ARNT/ELOB/GRB2	1.20243560457591
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/1050	19/9376	1.87989974937343	NAGLU/HEXA/HYAL4/GALNS	1.36333870420968
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/1050	33/9376	1.62354978354978	VAMP8/STX7/VAMP4/SEC22B/VAMP7/BET1	1.27422761477823
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	19/1050	133/9376	1.2756462585034	GNGT1/ITPR2/GNG2/PRKACA/KCNJ5/CALM3/AKT1/COMT/GRIA4/MAPK9/GNB2/PRKACB/MAPK14/PPP2R2A/DRD4/PPP1CB/GNG7/CREB3L1/ARRB2	1.13692948707188
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	21/1050	149/9376	1.25852348993289	FCER1G/CXCL8/SYK/CYTH4/KITLG/PDGFC/RRAS/LPAR6/GRM7/MAP2K2/ARF6/PDGFRA/DGKB/AKT1/AGPAT1/LPAR5/DGKZ/PDGFRB/GNA13/TSC2/GRB2	1.12960074048547
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	10/1050	63/9376	1.41738473167045	POLE3/POLR2J/RPA3/POLR2K/POLR2E/XPA/ERCC3/POLE/GTF2H5/ERCC8	1.18038617918693
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	8/1050	48/9376	1.48825396825397	HMGCLL1/ACAA1/IVD/ACAA2/DLD/ALDH7A1/HIBADH/ALDH1B1	1.20429869603049
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	22/1050	158/9376	1.24335141651597	WNT2/LAMTOR4/ATP6V1F/LAMTOR2/ATP6V1A/LAMTOR5/EIF4E2/LRP6/MAP2K2/FZD2/AKT1/FZD4/TBC1D7/LAMTOR1/TELO2/TSC2/PDPK1/GRB2/MIOS/LAMTOR3/DVL3/IRS1	1.09548429186708
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/1050	41/9376	1.52455284552846	ALAS2/GRHPR/GATM/DLD/ALDH7A1/PHGDH/ALAS1	1.19532526468322
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	9/1050	56/9376	1.43510204081633	DISP1/GRK3/PRKACA/CSNK1G2/PRKACB/GLI3/EFCAB7/SUFU/ARRB2	1.15968292337146
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	43/1050	333/9376	1.15306163306163	SPP1/LAMA2/RBPJ/FN1/WNT2/COL1A1/COL4A1/JAG1/PSMC1/HEY1/CDK6/COL1A2/ATP6V1F/ATP6V1A/ATP6V0A1/VTN/BAD/BAX/PRKACA/MAP2K2/ATP6AP1/MAML2/TP53/TCIRG1/COL4A2/LAMC3/ATP6V0D1/FZD2/AKT1/MFNG/PRKACB/FZD4/PDGFRB/NOTCH3/PPP2R2A/ITGA3/TSC2/GRB2/CREB3L1/ATM/DVL3/IKBKG/ATP6V0B	1.00993698872064
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/1050	20/9376	1.78590476190476	LIPA/FDFT1/SC5D/CYP2R1	1.24940113446919
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/1050	80/9376	1.33942857142857	HGF/PDGFC/EIF4E2/BAD/BAX/FGFR3/MAP2K2/PDGFRA/AKT1/PDGFRB/GRB2/FGFR2	1.08269820490556
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/1050	42/9376	1.48825396825397	FTL/CYBB/FTH1/PRNP/TP53/ATG7/SLC40A1	1.12615615046823
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	30/1050	227/9376	1.18011327879169	CCL3/GNGT1/CCL4/ITPR2/CCL4L2/CCL3L1/GNG2/CXCL8/CCL2/CCR1/CDK6/BAX/PRKACA/MAP2K2/CXCL12/CALM3/TP53/PDGFRA/AKT1/IL10RB/GNB2/PRKACB/MAPK14/GNA13/IL10RA/GNG7/TSC2/GRB2/CREB3L1/IKBKG	0.975514954552228
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/1050	50/9376	1.42872380952381	SRM/GATM/AOC1/CNDP2/P4HA2/PYCR2/ALDH7A1/ALDH1B1	1.07938650533771
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	13/1050	89/9376	1.30431246655966	SPP1/LAMA2/FN1/COL1A1/CD36/FREM1/COL4A1/FRAS1/COL1A2/VTN/COL4A2/LAMC3/ITGA3	1.02432815297324
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/1050	89/9376	1.30431246655966	ADRB1/ITPR2/PDGFC/PRKACA/MAP2K2/TUBB/TUBA1B/HTR2C/PDGFRA/PRKACB/PDGFRB/TUBB2A/GRB2	1.02432815297324
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	21/1050	154/9376	1.21766233766234	IDO2/IDO1/ALAS2/AKR1A1/UROD/PPCS/MOCS2/UROS/DLD/MAT2B/FLAD1/QPRT/HAAO/KYNU/ALAS1/COX15/AFMID/AK6/MTHFD2/ALDH1B1/PPCDC	0.967148527781601
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	31/1050	238/9376	1.16308923569428	GNGT1/IGF2/HGF/ANGPT1/CSF1R/GNG2/PLAAT3/KITLG/PDGFC/PLA2G2A/VEGFB/BAD/RRAS/PRKACA/FGFR3/MAP2K2/CALM3/ARF6/PDGFRA/AKT1/FGF10/MAPK9/GNB2/FGF7/PRKACB/PDGFRB/GNG7/GRB2/IKBKG/BDNF/FGFR2	0.905003551629787
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	9/1050	59/9376	1.36213075060533	ADRB1/PDE3B/CGA/PLAAT3/NPY1R/PRKACA/AKT1/PRKACB/IRS1	0.990867188287366
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	14/1050	99/9376	1.26276094276094	JAG1/BAD/BAX/PRKACA/MAP2K2/TP53/AKT1/MAPK9/CARM1/PRKACB/MAPK14/NOTCH3/DLL4/GRB2	0.933333200610964
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	7/1050	44/9376	1.42060606060606	TAF10/TAF12/GTF2A2/GTF2B/ERCC3/GTF2H5/GTF2I	0.993062503427883
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	16/1050	116/9376	1.23165845648604	IDH3G/TKT/TALDO1/SDHD/ADPGK/RPE/SUCLG2/DLD/PGP/ADH5/FH/SUCLA2/PGLS/G6PD/PHGDH/RPIA	0.891525447506429
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/1050	37/9376	1.44803088803089	HBA2/HBA1/HBB/IDO2/IDO1/MYD88	0.969662755614809
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/1050	15/9376	1.78590476190476	ST3GAL5/HEXA/ST3GAL2	1.08172411501176
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/1050	61/9376	1.31747072599532	FTL/ATP1B1/FTH1/SLC8A1/STEAP1/SLC46A1/SLC40A1/ATP7A/ATOX1	0.883363107350648
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	12/1050	85/9376	1.26063865546218	ENPP1/APRT/DUT/ITPA/NTPCR/LACC1/CANT1/ENTPD6/TK1/IMPDH2/DTYMK/AK6	0.857194042208068
Organismal Systems	Endocrine system	hsa04924	Renin secretion	10/1050	69/9376	1.29413388543823	ADRB1/ITPR2/PDE3B/PDE1C/PRKACA/CALM3/ORAI1/PRKACB/CTSB/EDNRA	0.870816867811013
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	6/1050	38/9376	1.40992481203008	PTPRC/CD4/ORAI1/UNG/IKBKG/BLNK	0.899147941122295
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/1050	23/9376	1.55296066252588	GGPS1/NUS1/IDI1/ICMT	0.942854703900972
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	22/1050	169/9376	1.16242321780783	VAMP8/UBA52/STX7/BAD/NBR1/RRAS/PRKACA/MAP2K2/TAX1BP1/MTMR14/ATG7/WIPI2/AKT1/NRBF2/MAPK9/PRKACB/CTSB/TSC2/PDPK1/GABARAP/WIPI1/IRS1	0.756649022490557
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	17/1050	128/9376	1.18595238095238	ENPP1/PDE3B/PAPSS2/PDE1C/APRT/ITPA/NTPCR/PDE4A/NUDT5/LACC1/ATIC/PAPSS1/PDE6G/CANT1/ENTPD6/IMPDH2/AK6	0.752220044994593
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1050	16/9376	1.67428571428571	FUT9/HEXA/ST3GAL2	0.958579440455698
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/1050	39/9376	1.37377289377289	DLD/ALDH7A1/MAT2B/ATIC/MTHFR/MTHFD2	0.830612593498698
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/1050	71/9376	1.25767940979209	SLC2A1/FGFR3/MAP2K2/TIGAR/TP53/PDGFRA/AKT1/G6PD/PDGFRB/FGFR2	0.773949790748777
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	37/1050	298/9376	1.10869926494088	CXCL14/CCL3/BMP5/CSH1/CCL4/CCL4L2/CSF1R/PRLR/CCL3L1/IL12RB2/CXCL8/EDA/CCL2/CCR1/CD4/IFNGR2/TNFSF12/CCL8/IL13RA2/EBI3/TNFSF10/TGFB1/IL17RA/CXCL12/CNTFR/CX3CR1/TNFRSF19/IFNGR1/IL10RB/TNFRSF25/ACVR2A/CSH2/IL13RA1/IL10RA/GDF6/LIFR/IL16	0.677176275684677
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/1050	97/9376	1.19674030436917	GNGT1/GNG2/RYR1/GRIN2C/PRKACA/KCNJ5/CALM3/RYR2/GRIA4/GNB2/PRKACB/RPS6KA5/GNG7	0.691656883001881
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/1050	89/9376	1.20398073836276	GNGT1/GNG2/GABRA3/PRKACA/TRAK2/NSF/SLC12A5/GABRA2/GNB2/PRKACB/GNG7/GABARAP	0.686607470707363
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1050	17/9376	1.57579831932773	PAPSS2/SEPHS2/PAPSS1	0.843805233013554
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/1050	73/9376	1.2232224396608	HGF/CDK6/BAD/BAX/MAP2K2/TP53/AKT1/RARB/PDPK1/GRB2	0.679907535267084
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	9/1050	65/9376	1.2363956043956	AKR1A1/AKR1B1/ABHD16A/ALDH7A1/DGKB/AGPAT1/MBOAT2/DGKZ/ALDH1B1	0.679141072825164
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/1050	65/9376	1.2363956043956	SPP1/ITPR2/CGA/KISS1/MAP2K2/KCNJ5/AKT1/TRPC1/ARRB2	0.679141072825164
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	20/1050	157/9376	1.13751895662724	C1QA/C1QC/SLC2A1/C1QB/CD36/ABCA1/LRP1/UQCRFS1/LIPA/MAP2K2/TGFB1/ALOX5/CX3CR1/ARNT/CD24/TYRO3/MAPK14/ADAM9/SIRT1/VPS8	0.617067355686789
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	20/1050	157/9376	1.13751895662724	IGFBP3/ITPR2/ZFP36L1/CXCL8/CDK6/GATA4/NBN/RRAS/MAP2K2/TGFB1/CALM3/TP53/AKT1/MAPK14/PPP1CB/TSC2/ATM/SIRT1/SLC25A5/RAD1	0.617067355686789
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/1050	57/9376	1.25326649958229	ELOVL2/HACD3/ACAA1/ACAA2/PPT1/MCAT/SCD5/HSD17B8	0.681071338731853
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	12/1050	90/9376	1.19060317460317	KL/EIF4E2/BAX/PRKACA/TP53/AKT1/PRKACB/ADIPOR1/TSC2/CREB3L1/SIRT1/IRS1	0.645207087343842
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	6/1050	41/9376	1.30675958188153	NBN/SSBP1/RPA3/RAD52/RAD51C/ATM	0.699028670862038
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/1050	41/9376	1.30675958188153	MMP1/CXCL8/FGFR3/MAP2K2/TP53/RPS6KA5	0.699028670862038
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1050	18/9376	1.48825396825397	MMADHC/MTRR/THAP11	0.73629626638385
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	10/1050	75/9376	1.19060317460317	IGFBP3/SIVA1/CDK6/BAX/TP53/SHISA5/ZMAT3/TSC2/APAF1/ATM	0.58851566018511
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	21/1050	168/9376	1.11619047619048	CSH1/PRLR/IL12RB2/IFNGR2/IL13RA2/PTPN2/STAM/PDGFRA/AKT1/STAT6/CNTFR/IFNGR1/IL10RB/PDGFRB/CSH2/IL13RA1/PIM1/IL10RA/GRB2/LIFR/PIAS2	0.539640581522642
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/1050	34/9376	1.31316526610644	POLR2J/POLR2K/POLR2E/POLR1A/POLR3K	0.649613735268583
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/1050	26/9376	1.37377289377289	SCARB1/SLC19A3/SLC46A1/FOLH1	0.677720708060462
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	25/1050	203/9376	1.09969505043397	SPP1/LAMA2/FN1/HGF/COL1A1/ACTB/COL4A1/PDGFC/COL1A2/VEGFB/VTN/BAD/XIAP/VAV1/COL4A2/LAMC3/PDGFRA/AKT1/MAPK9/PDGFRB/VASP/PPP1CB/ITGA3/PDPK1/GRB2	0.5099504790108
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/1050	43/9376	1.24598006644518	ACAA1/ACAA2/ALDH7A1/ADH5/GCDH/ALDH1B1	0.574097418247394
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	24/1050	196/9376	1.0934110787172	GNGT1/ITPR2/GNG2/CXCL8/SYK/CCR1/CD86/UBA52/CD200R1/CDK6/HCK/BAX/MAP2K2/CALM3/TP53/AKT1/MAPK9/IFNGR1/GNB2/LYN/MAPK14/PREX1/GNG7/IKBKG	0.469317952073405
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/1050	27/9376	1.32289241622575	ELOVL2/HACD3/ACAA1/SCD5	0.596649431988455
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/1050	52/9376	1.20205128205128	HSD17B2/SCARB1/CGA/PRKACA/ALOX5/HSD17B1/PRKACB	0.518828989595445
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	15/1050	120/9376	1.11619047619048	BAD/BAX/MAP2K2/CALM3/TP53/AKT1/MAPK9/MAPK14/RPS6KA5/IRAK1/PDPK1/GRB2/IRS1/MAP3K5/BDNF	0.454895421936623
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/1050	44/9376	1.21766233766234	POLE3/PARP1/POLE/PARG/PARP2/UNG	0.513906779254363
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/1050	44/9376	1.21766233766234	PRKACA/NSF/DCTN5/DYNLL2/PRKACB/CREB3L1	0.513906779254363
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/1050	36/9376	1.24021164021164	KL/AKR1A1/AKR1B1/RPE/CRYL1	0.512783385599192
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	5/1050	36/9376	1.24021164021164	POLE3/SSBP1/RPA3/POLE/POLA2	0.512783385599192
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1050	28/9376	1.2756462585034	ELOVL2/HACD3/ACAA2/PPT1	0.518721023649505
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	20/1050	166/9376	1.0758462421113	ADRB1/ITPR2/PDE3B/ATP1B1/KCNMB4/SLC8A1/GATA4/BAD/RGS2/MAP2K2/CALM3/AKT1/GNA13/GTF2I/VASP/PPP1CB/CREB3L1/SLC25A5/EDNRA/IRS1	0.350122790707945
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/1050	54/9376	1.15753086419753	SRM/LACC1/MAT2B/ENOPH1/PHGDH/MTAP/TST	0.412258928904038
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/1050	63/9376	1.13390778533636	PRDM6/MECOM/BBOX1/PRDM16/DLD/ALDH7A1/GCDH/ALDH1B1	0.378698325796373
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/1050	63/9376	1.13390778533636	PTGDS/HPGDS/PLAAT3/TBXAS1/PLA2G2A/LTC4S/ALOX5/HPGD	0.378698325796373
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	8/1050	63/9376	1.13390778533636	WNT2/BAX/TP53/FZD2/FZD4/GLI3/SUFU/DVL3	0.378698325796373
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	12/1050	98/9376	1.0934110787172	ITPR2/CALM3/MTMR14/SACM1L/DGKB/IPMK/PIP4P2/INPP5D/PIK3C2B/CDS1/DGKZ/INPPL1	0.330100609019969
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/1050	55/9376	1.13648484848485	CERS2/SGPP1/HEXA/SGPL1/ASAH1/NEU1/SMPD1	0.36049281830998
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/1050	38/9376	1.1749373433584	GFPT1/HEXA/GNPDA1/NAGK/UXS1	0.383715616839913
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	20/1050	170/9376	1.05053221288515	ACTB/OCLN/RUNX1/CGNL1/CLDN11/JAM2/GATA4/JAM3/PRKACA/WAS/TUBA1B/ARPC5/MAPK9/EZR/PRKACB/PPP2R2A/ARPC2/VASP/ARHGEF18/MAP3K5	0.236112716027265
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	20/1050	170/9376	1.05053221288515	IGF2/HGF/WNT2/ACTB/CDK6/SMARCB1/BAD/BAX/LRP6/MAP2K2/TGFB1/TP53/FZD2/AKT1/GSTP1/FZD4/GSTA4/SMARCD2/GRB2/DVL3	0.236112716027265
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	17/1050	144/9376	1.05417989417989	WNT2/TBX3/FGFR3/MAP2K2/DUSP9/BMI1/FZD2/AKT1/FZD4/ISL1/MAPK14/ACVR2A/GRB2/TCF3/DVL3/LIFR/FGFR2	0.232666354421528
NA	NA	hsa03272	Virion - Hepatitis viruses	6/1050	48/9376	1.11619047619048	SCARB1/OCLN/CLDN11/VPS4B/CHMP1B/TGOLN2	0.286588636376567
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	27/1050	233/9376	1.03475168608216	LAMA2/COL3A1/FN1/DCN/TNNT3/COL1A1/ACTB/ATP1B1/NEBL/COL11A1/COL4A1/VCAN/FBLN1/COL1A2/PKP2/CAPZB/TNNT1/COL4A2/CAPZA1/DSC2/ANK3/CAPZA2/ITGA3/ANKRD23/LMNB1/COL5A1/SGCB	0.190753082895378
Human Diseases	Infectious disease: viral	hsa05162	Measles	16/1050	136/9376	1.05053221288515	FCGR2B/CD28/CDK6/CD209/BAD/BAX/TP53/TLR2/AKT1/TLR7/MAPK9/SLAMF1/MYD88/IRAK1/APAF1/IKBKG	0.210796730272316
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1050	31/9376	1.15219662058372	KL/AKR1A1/ALDH7A1/ALDH1B1	0.301410437848909
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/1050	31/9376	1.15219662058372	GRHPR/DLD/PGP/AFMID	0.301410437848909
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/1050	76/9376	1.05744360902256	ITPR2/ACTB/ATP1B1/KCNQ1/PRKACA/CALM3/HRH2/EZR/PRKACB	0.178553810938392
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/1050	76/9376	1.05744360902256	CDK6/BAX/MAP2K2/CALM3/TP53/PDGFRA/AKT1/PDGFRB/GRB2	0.178553810938392
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1050	23/9376	1.16472049689441	SSBP1/RPA3/MSH6	0.280865359601473
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	29/1050	254/9376	1.01951256092988	ADRB1/HGF/ITPR2/PDE1C/SLC8A1/PDGFC/VEGFB/RYR1/GRIN2C/PRKACA/FGFR3/CALM3/HRH2/HTR2C/PDGFRA/HRH1/P2RX7/RYR2/FGF10/ORAI1/FGF7/PRKACB/ORAI3/PHKG2/PDGFRB/PHKA2/SLC25A5/EDNRA/FGFR2	0.111956208179224
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/1050	94/9376	1.04494427558257	S100A9/MMP1/CXCL8/CCL2/SRSF1/IL17RA/TAB3/MAPK9/S100A8/MAPK14/IKBKG	0.155517624554459
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/1050	32/9376	1.11619047619048	ECHDC1/SUCLG2/DLD/SUCLA2	0.233798214595302
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/1050	32/9376	1.11619047619048	ATG7/WIPI2/GABARAP/WIPI1	0.233798214595302
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/1050	32/9376	1.11619047619048	BAX/XIAP/MAPK9/APAF1	0.233798214595302
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	23/1050	201/9376	1.02178630656243	CD14/IGFBP3/CSF1R/FCGR1A/PROM1/CXCL8/SPI1/CD86/RUNX1/NR4A3/ITGAM/BAX/MAF/HOXA11/CEBPA/KLF3/TP53/BMI1/BCL2A1/HPGD/BMP2K/ATM/TCF3	0.110876800973956
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	17/1050	148/9376	1.02568854568855	WNT2/JAG1/HEY1/CDK6/BAX/LRP6/MAP2K2/TP53/FZD2/AKT1/FGF10/FGF7/FZD4/NOTCH3/DLL4/GRB2/DVL3	0.111860992253747
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/1050	59/9376	1.05943502824859	HPGDS/SRM/GPX7/GSTP1/G6PD/GSTA4/GGT7	0.162626949597668
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/1050	59/9376	1.05943502824859	BAD/BAX/MAP2K2/TP53/AKT1/PDPK1/GRB2	0.162626949597668
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	9/1050	77/9376	1.04371057513915	CDK6/BAD/BAX/TGFB1/TP53/AKT1/MAPK9/ARHGEF6/IKBKG	0.136765275330287
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1050	15/9376	1.19060317460317	NTPCR/ACP1	0.262347373829804
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1050	24/9376	1.11619047619048	HS3ST3A1/EXTL2/B4GALT7	0.202388572791506
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/1050	69/9376	1.03530710835059	GRIN2C/PRKACA/CALM3/GRIA4/PRKACB/PPP1CB/CREB3L1/SIRT1	0.104530715526071
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	10/1050	87/9376	1.0263820470717	AREG/BAD/BAX/MAP2K2/TGFB1/MSH6/TP53/AKT1/MAPK9/GRB2	0.0877901356772434
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	12/1050	105/9376	1.02051700680272	FCER1G/ITPR2/CLEC7A/SYK/CD209/RRAS/CALM3/NLRP3/AKT1/MAPK9/MAPK14/IKBKG	0.0750770925850746
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	22/1050	195/9376	1.00743345543346	CYBB/FCGR3A/CYBA/CR1/FCGR2A/ACTB/FCGR1A/NCF4/CLEC7A/SYK/ITGB2/NCF2/ITGAM/MAP2K2/HDAC9/ATG7/TLR2/AKT1/TLR7/FPR1/MAPK14/SLC25A5	0.0372499023377252
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	16/1050	142/9376	1.00614352783367	CYBA/ACTB/CCL2/NCF2/CALM3/TXN2/TP53/AKT1/MAPK9/GSTP1/MAPK14/GSTA4/ACVR2A/CDH5/IKBKG/MAP3K5	0.026195648345486
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	21/1050	187/9376	1.0027807486631	CYBB/CARD18/CYBA/ITPR2/CXCL8/CCL2/XIAP/TXN2/NLRP3/TAB3/ANTXR1/P2RX7/TRPM2/MAPK9/PKN1/MYD88/CTSB/MAPK14/GABARAP/TRPV2/IKBKG	0.0136398784149462
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/1050	79/9376	1.01728752260398	ATP6V1F/ATP6V1A/ATP6V0A1/SYT1/NSF/TCIRG1/ATP6V0D1/AP2S1/ATP6V0B	0.054794500914671
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1050	43/9376	1.03831672203765	CD36/ABCA1/SCARB1/PLA2G2A/AGPAT1	0.0894281049493961
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	25/1050	224/9376	0.996598639455782	SLC2A1/NRP1/SPI1/CD4/ITGB2/ANAPC11/BAX/RANBP1/PRKACA/MAP2K2/XIAP/TGFB1/ANAPC13/TP53/ANAPC15/AKT1/EGR1/MAPK9/TSPO/PRKACB/CREB3L1/ATM/TCF3/SLC25A5/IKBKG	-0.0182970366287352
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/1050	107/9376	1.00144192256342	SLC2A1/ITPR2/PDE3B/PRKACA/CALM3/PPP4C/AKT1/PRKACB/PHKG2/PHKA2/CREB3L1/SIRT1	0.00532696042094653
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	20/1050	180/9376	0.992169312169312	SYK/CCL2/SRSF1/IFNGR2/POU2F2/BAD/BAX/TP53/SRSF6/TLR2/AKT1/IFNGR1/MYD88/SRSF9/PPP1CB/SRSF3/IRAK1/TSC2/APAF1/IKBKG	-0.0376702729433352
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/1050	53/9376	1.01088948787062	ATP1B1/KL/SLC8A1/PRKACA/PRKACB/AP2S1	0.0282312191057788
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	25/1050	226/9376	0.987779182469448	ADRB1/PDE3B/ATP1B1/CGA/NPY1R/BAD/RRAS/GRIN2C/PRKACA/MAP2K2/VAV1/CALM3/PDE4A/AKT1/RYR2/GRIA4/MAPK9/ORAI1/PRKACB/VIPR2/GLI3/PPP1CB/CREB3L1/EDNRA/BDNF	-0.0660398406522704
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	10/1050	90/9376	0.992169312169312	CD28/CD4/IFNGR2/MAP2K2/TLR2/AKT1/IFNGR1/MYD88/MAPK14/IKBKG	-0.0265075085850793
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	18/1050	163/9376	0.986082383873795	CXCL8/BAD/BAX/MAP2K2/ATP6AP1/TGFB1/TP53/TLR2/AKT1/STAT6/MAPK9/MYD88/MAPK14/IRAK1/GRB2/CREB3L1/APAF1/IKBKG	-0.0636531946037897
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1050	26/9376	1.03032967032967	PLAAT3/PLA2G2A/ACAA1	0.0549934090821309
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	11/1050	100/9376	0.982247619047619	CD14/CR1/CSF1R/CD36/FCGR1A/CD4/KITLG/ITGAM/CD33/CD24/ITGA3	-0.06337796982846
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	12/1050	110/9376	0.97412987012987	SLC2A1/CYBB/ANGPT1/IFNGR2/EIF4E2/EPAS1/MAP2K2/AKT1/ARNT/IFNGR1/ELOB/MKNK1	-0.0969194381920622
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	12/1050	110/9376	0.97412987012987	BMP5/DCN/IGSF1/PITX2/SMAD6/ZFYVE16/TGFB1/BAMBI/FMOD/ACVR2A/FST/GDF6	-0.0969194381920622
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/1050	93/9376	0.960163850486431	ITPR2/CGA/PRKACA/MAP2K2/CALM3/EGR1/MAPK9/PRKACB/MAPK14/GRB2	-0.137099773472027
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	8/1050	75/9376	0.95248253968254	IDH3G/TKT/TALDO1/PYCR2/RPE/MAT2B/PHGDH/RPIA	-0.146717228541817
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1050	18/9376	0.992169312169312	MCAT/HSD17B8	-0.0118088261188568
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	23/1050	214/9376	0.959715175789942	GNGT1/ITPR2/GNG2/CD4/RNF7/BAD/BAX/MAP2K2/CALM3/AP1M1/TLR2/AKT1/MAPK9/APOBEC3G/GNB2/MYD88/MAPK14/ELOB/IRAK1/GNG7/ATM/LIMK1/IKBKG	-0.211697290855712
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	22/1050	205/9376	0.958290360046458	RBPJ/SYK/PSMC1/CDK6/ADRM1/PSMC2/PSMD3/BAX/CD58/TP53/PSMD6/TLR2/AKT1/MAPK9/LYN/MYD88/MAPK14/CIR1/IRAK1/APAF1/IKBKG/BLNK	-0.214420897352431
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	13/1050	122/9376	0.951506635441062	PTPRC/CD28/CD4/LCP2/MAP2K2/VAV1/AKT1/MAPK9/MAPK14/PPP2R2A/PDPK1/GRB2/IKBKG	-0.191451850984569
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	13/1050	122/9376	0.951506635441062	IGFBP3/CSH1/ITPR2/PRKACA/MAP2K2/AKT1/MAPK9/PRKACB/MAPK14/CSH2/GRB2/CREB3L1/IRS1	-0.191451850984569
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	7/1050	66/9376	0.947070707070707	IL12RB2/IFNGR2/MAF/TGFB1/TLR2/STAT6/IFNGR1	-0.153234058440042
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	40/1050	370/9376	0.965353925353925	ADRB1/CSH1/PRLR/SPX/P2RY1/CGA/APLNR/C3AR1/VIPR1/TAC3/GABRA3/KISS1/NPY1R/APLN/LYPD6/GRIN2C/LPAR6/GRM7/OGFRL1/HRH2/CORT/PTH2R/HTR2C/HRH1/P2RY13/P2RX7/GRIA4/GABRA2/FPR1/TSPO/VIPR2/PGRMC2/DRD4/CSH2/PENK/S1PR4/NPY5R/EDNRA/NMUR1/CHRNE	-0.241463233410766
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/1050	28/9376	0.956734693877551	AKR1B1/MOCS2/QDPR	-0.0814182060812157
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	16/1050	150/9376	0.95248253968254	HGF/WNT2/BAX/LRP6/MAP2K2/TGFB1/TP53/FZD2/AKT1/FGF10/FGF7/FZD4/RARB/GRB2/DVL3/FGFR2	-0.208331149212881
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	11/1050	104/9376	0.944468864468864	PLAAT3/PLA2G2A/CHKB/PNPLA6/PLD4/DGKB/LYPLA2/AGPAT1/MBOAT2/CDS1/DGKZ	-0.202222091072115
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/1050	67/9376	0.932935323383085	ITPR2/GRIN2C/PRKACA/MAP2K2/CALM3/PRKACB/PPP1CB	-0.195632860637976
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/1050	86/9376	0.934485049833887	LAMA2/ACTB/SLC8A1/PKP2/CDH2/DSC2/RYR2/ITGA3/SGCB	-0.216742395045142
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	14/1050	133/9376	0.939949874686717	MAP2K2/TNFSF10/TGFB1/AKT1/CDKN2D/MAPK9/MAPK14/S1PR4/PDPK1/GRB2/GABARAP/ATM/SIRT1/IRS1	-0.247682513601724
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1050	29/9376	0.923743842364532	GNGT1/CALM3/PDE6G	-0.146049434756596
NA	NA	hsa04082	Neuroactive ligand signaling	21/1050	199/9376	0.942311557788945	GNGT1/ADRB1/P2RY1/GNG2/TAC3/GABRA3/GRIN2C/PRKACA/GRM7/OGFRL1/HRH2/HTR2C/HRH1/P2RY13/GRIA4/GABRA2/GNB2/PRKACB/DRD4/PENK/GNG7	-0.292096981111199
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1050	49/9376	0.911175898931001	GRIN2C/PRKACA/PRKACB/CREB3L1/BDNF	-0.221370607590495
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	12/1050	116/9376	0.923743842364532	GNGT1/ITPR2/GNG2/GRK3/GRIN2C/PRKACA/GRM7/TRPC1/GRIA4/GNB2/PRKACB/GNG7	-0.293467832309318
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/1050	59/9376	0.908087167070218	ENPP1/DUT/CANT1/ENTPD6/TK1/DTYMK	-0.251493169747181
NA	NA	hsa04081	Hormone signaling	23/1050	219/9376	0.93780387040661	GNGT1/ADRB1/IGF2/CSH1/SLC16A10/PRLR/GNG2/CGA/VIPR1/PRKACA/GNB2/PRKACB/VIPR2/SLC16A2/GNA13/DRD4/CSH2/PENK/NPR3/ADIPOR1/GNG7/SLC40A1/IRS1	-0.330727946688866
NA	NA	hsa04519	Cadherin signaling	43/1050	404/9376	0.95041961338991	WNT2/ACTB/CDH11/PCDH10/VANGL2/GABRA3/NCKAP1L/KRT7/PKP2/RRAS/KRT1/CDH2/MOB1A/KRT19/LRP6/MAP2K2/APH1A/VAV1/FMN1/ARPC5/DSC2/FZD2/PDGFRA/CYFIP1/MAPK9/GABRA2/ABI2/FZD4/TAOK2/MYO1F/PDGFRB/KRT23/MAPK14/ARPC2/VASP/PPP1CB/NCSTN/MOB1B/CDH5/DVL3/TAOK3/PCDH18/IKBKG	-0.361757916278397
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	18/1050	173/9376	0.929083402146986	ACTB/CXCL8/CCL2/CDK6/IFNGR2/BAX/MAP2K2/TNFSF10/NLRP3/KPNA2/AKT1/TLR7/IFNGR1/MYD88/APAF1/SLC25A5/CPSF4/IKBKG	-0.334324587653113
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/1050	30/9376	0.892952380952381	PIGC/PIGN/MPPE1	-0.208538783432747
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1050	20/9376	0.892952380952381	NPL/CYB5R4	-0.170180183609231
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/1050	70/9376	0.892952380952381	SLC2A1/CD36/AKT1/MAPK9/ADIPOR1/IRS1/IKBKG	-0.319232127709652
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/1050	70/9376	0.892952380952381	LAMA2/ACTB/CD28/CD86/ITGB2/EIF4G2/SGCB	-0.319232127709652
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	10/1050	99/9376	0.901972101972102	ITPR2/PRKACA/CALM3/HTR2C/HRH1/MAPK9/PRKACB/MAPK14/PPP1CB/TRPV2	-0.348197456038139
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	4/1050	41/9376	0.871173054587689	GABRA3/GRIN2C/GRIA4/GABRA2	-0.293564516780317
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/1050	31/9376	0.864147465437788	CNDP2/ALDH7A1/ALDH1B1	-0.269042582997149
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/1050	71/9376	0.88037558685446	PRLR/CGA/MAP2K2/AKT1/MAPK9/MAPK14/GRB2	-0.359296420296595
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/1050	21/9376	0.850430839002267	CSGALNACT2/B4GALT7	-0.243664294039906
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	21/1050	205/9376	0.914731707317073	RBPJ/SYK/PSMC1/CDK6/MRPS18B/SCIN/BAD/BAX/RANBP1/PRKACA/TP53/HDAC9/ATP6V0D1/GTF2A2/LYN/PRKACB/GTF2B/GRB2/CREB3L1/DNAJA3/IKBKG	-0.438347198708678
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/1050	101/9376	0.884111268269684	WNT2/KITLG/PRKACA/MAP2K2/CALM3/FZD2/PRKACB/FZD4/CREB3L1/DVL3	-0.415821578054277
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/1050	62/9376	0.864147465437788	PRKACA/AKT1/CLPB/PRKACB/SIRT1/IRS1	-0.38111633000925
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	17/1050	168/9376	0.903582766439909	FTL/CYBB/FTH1/VPS4B/IFNGR2/CHMP1B/BAX/CHMP5/PARP1/TNFSF10/XIAP/NLRP3/STAT6/MAPK9/IFNGR1/SLC25A5/SMPD1	-0.447804791692871
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	26/1050	253/9376	0.917658573310747	CD14/ITPR2/ACTB/CXCL8/CYTH4/UBA52/WASL/BAX/TP53/ARF6/NLRP3/ARPC5/TAB3/WIPI2/AKT1/MAPK9/MYD88/MAPK14/ARPC2/RPS6KA5/UBE2D4/ATM/U2AF1/WIPI1/UBE2V2/IKBKG	-0.471489358475118
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	13/1050	133/9376	0.87281059792338	FCER1G/TYROBP/FCGR3A/HCST/SYK/ITGB2/LCP2/IFNGR2/MAP2K2/TNFSF10/VAV1/IFNGR1/GRB2	-0.524604913736445
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1050	23/9376	0.77648033126294	FUT9/POMGNT1	-0.381123984698027
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1050	23/9376	0.77648033126294	ATP6AP2/NLN	-0.381123984698027
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/1050	75/9376	0.833422222222222	ITPR2/ATP1B1/CGA/GPX7/PRKACA/PRKACB/CREB3L1	-0.514333672905281
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/1050	65/9376	0.824263736263736	ITPR2/SCARB1/PRKACA/ORAI1/PRKACB/CREB3L1	-0.504872816875234
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/1050	105/9376	0.850430839002267	LAMA2/ADRB1/ACTB/SLC8A1/PRKACA/TGFB1/RYR2/PRKACB/ITGA3/SGCB	-0.547312668756801
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	11/1050	115/9376	0.854128364389234	GNGT1/ITPR2/GNG2/PRKACA/KCNJ5/ALOX5/HTR2C/TRPC1/GNB2/PRKACB/GNG7	-0.558924201604445
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	15/1050	155/9376	0.864147465437788	ITPR2/WNT2/SCARB1/CDK6/PRKACA/MAP2K2/FZD2/RBBP5/FH/ARNT/ORAI1/PRKACB/FZD4/CREB3L1/DVL3	-0.605629007085929
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	15/1050	156/9376	0.858608058608059	SCARB1/OCLN/CLDN11/CDK6/BAD/BAX/MAP2K2/TP53/EIF3E/AKT1/IFIT1/PPP2R2A/GRB2/APAF1/IKBKG	-0.632387942396935
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	11/1050	117/9376	0.839527879527879	ACTB/SMARCB1/MBD3/POLE3/RBBP7/RUVBL1/UCHL5/DPF2/SMARCD2/MTA1/MCRS1	-0.620258271695988
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/1050	67/9376	0.799658848614072	AKR1A1/ADPGK/DLD/ALDH7A1/ADH5/ALDH1B1	-0.584410669315733
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	9/1050	98/9376	0.820058309037901	ITPR2/ATP1B1/SCARB1/PRKACA/KCNJ5/CALM3/ORAI1/PRKACB/CREB3L1	-0.635886691283162
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/1050	78/9376	0.801367521367521	MTMR14/SACM1L/IPMK/INPP5D/PIK3C2B/FIG4/INPPL1	-0.625554102834414
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/1050	78/9376	0.801367521367521	FN1/ACTB/ARHGEF26/WASL/RHOG/ARPC5/ARPC2	-0.625554102834414
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	15/1050	158/9376	0.847739602169982	CDKN1C/ANAPC11/CDK6/SMC3/SMC1A/RAD21/TGFB1/ANAPC13/TP53/DBF4/ANAPC15/PDS5B/CDKN2D/ORC4/ATM	-0.685423888154226
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/1050	109/9376	0.819222367846221	CD4/RUNX1/IFNGR2/EBI3/TGFB1/STAT6/MAPK9/IFNGR1/MAPK14/IKBKG	-0.674140541539463
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	10/1050	109/9376	0.819222367846221	SLC2A1/CD36/GFPT1/AKT1/MAPK9/PPP1CB/PDPK1/CREB3L1/IRS1/SREBF1	-0.674140541539463
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/1050	119/9376	0.825418167266907	CCL2/JAG1/XIAP/TAB3/AKT1/MAPK9/MAPK14/RPS6KA5/CREB3L1/IKBKG/MAP3K5	-0.68061181142594
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/1050	37/9376	0.724015444015444	GFPT1/NIT2/FOLH1	-0.597306909439387
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/1050	37/9376	0.724015444015444	GFPT1/NAGK/UXS1	-0.597306909439387
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/1050	37/9376	0.724015444015444	BAX/MAP2K2/TP53	-0.597306909439387
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	10/1050	110/9376	0.811774891774892	PDE3B/ANAPC11/PRKACA/ANAPC13/ANAPC15/AKT1/MAPK9/PRKACB/MAPK14/CPEB4	-0.70516351616313
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1050	14/9376	0.637823129251701	ST3GAL2	-0.481573406171106
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/1050	38/9376	0.704962406015038	ENPP1/QPRT/SIRT1	-0.647149031724851
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/1050	38/9376	0.704962406015038	ATP1B1/PDPK1/IRS1	-0.647149031724851
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/1050	60/9376	0.744126984126984	ITPR2/RYR1/MAP2K2/LYN/GNA13	-0.706069509758694
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	11/1050	122/9376	0.80512099921936	CD36/AKT1/PPP2R2A/SCD5/ADIPOR1/TSC2/PDPK1/CREB3L1/SIRT1/IRS1/SREBF1	-0.769382486796325
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/1050	50/9376	0.714361904761905	CD28/CD86/TGFB1/CXCL12	-0.719143417186971
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/1050	72/9376	0.744126984126984	CXCL8/MAPK9/RNF125/SIKE1/MAPK14/IKBKG	-0.773959026767402
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	14/1050	154/9376	0.811774891774892	ADRB1/ATP1B1/SLC8A1/KCNQ1/PRKACA/CALM3/AKT1/RYR2/PRKACB/MAPK14/PPP2R2A/RPS6KA5/PPP1CB/CREB3L1	-0.836348806442801
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/1050	83/9376	0.753092369477912	CCL4/CCL4L2/POLR2K/POLR2E/NLRP3/POLR3K/IKBKG	-0.802338576847622
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/1050	73/9376	0.733933463796477	CD4/VPS4B/SMARCB1/PSIP1/APOBEC3G/BICD1	-0.810405276109697
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	10/1050	115/9376	0.77648033126294	GNGT1/ITPR2/GNG2/KCNQ1/PRKACA/AKT1/GNB2/PRKACB/GNG7/CREB3L1	-0.856441705535595
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/1050	115/9376	0.77648033126294	ITPR2/KL/PRKACA/LRP6/PDE4A/EGR1/PRKACB/GNA13/CREB3L1/ARRB2	-0.856441705535595
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/1050	29/9376	0.615829228243021	MOB1A/MOB1B	-0.735782208347397
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	14/1050	157/9376	0.796263269639066	BMP5/WNT2/ACTB/AREG/ITGB2/MOB1A/TGFB1/FZD2/FZD4/PPP2R2A/PPP1CB/MOB1B/GDF6/DVL3	-0.914196039174965
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	12/1050	138/9376	0.77648033126294	ITPR2/ANAPC11/SMC3/SMC1A/PRKACA/ANAPC13/CALM3/ANAPC15/PRKACB/MAPK14/PPP1CB/CPEB4	-0.939352063723235
Organismal Systems	Sensory system	hsa04742	Taste transduction	7/1050	86/9376	0.726821705426357	P2RY1/PDE1C/GABRA3/PRKACA/GABRA2/SCN9A/PRKACB	-0.903752772307906
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/1050	86/9376	0.726821705426357	SLC2A1/ATP1B1/KCNMB4/PRKACA/RYR2/PRKACB/CREB3L1	-0.903752772307906
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1050	30/9376	0.595301587301587	PLAAT3/PLA2G2A	-0.78839039478074
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1050	17/9376	0.525266106442577	GGT7	-0.695700091900842
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/1050	17/9376	0.525266106442577	CD209	-0.695700091900842
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/1050	76/9376	0.704962406015038	PLTP/CD36/MMP1/ACAA1/SCD5/PDPK1	-0.917074809060537
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/1050	54/9376	0.661446208112875	CENPX/RPA3/RAD51C/TELO2	-0.885996685987674
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1050	66/9376	0.676479076479077	HSD17B2/HSD17B1/COMT/HSD17B8/DHRS9	-0.936616027869611
Human Diseases	Immune disease	hsa05310	Asthma	2/1050	32/9376	0.558095238095238	PRG2/FCER1G	-0.889199766985411
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	16/1050	184/9376	0.77648033126294	SLIT2/EPHA3/NTNG1/NRP1/SEMA3G/ROBO2/RRAS/CXCL12/SEMA3F/SEMA6D/TRPC1/EPHA6/EPHA5/PLXNB2/PDPK1/LIMK1	-1.08738098254655
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	12/1050	143/9376	0.749330669330669	C1QA/C1QC/C1QB/FCGR3A/FCGR2A/FCGR1A/CD28/C7/CD86/C2/SSB/SNRPD3	-1.07265456852714
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/1050	45/9376	0.595301587301587	ABCA1/ABCC5/ABCB7	-0.966352885196792
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/1050	19/9376	0.469974937343358	DLD	-0.82123410381185
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/1050	33/9376	0.541183261183261	IDH3G/DLD	-0.937594678318256
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	8/1050	103/9376	0.693555247341655	MAGOH/SAP18/NUDT21/PPP2R2A/MAGOHB/PPP1CB/CPSF4/PABPC4L	-1.11051072224967
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/1050	70/9376	0.637823129251701	HPGDS/SULT1A1/GSTP1/GSTA4/SULT1A2	-1.08006599385243
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/1050	93/9376	0.672114695340502	ADRB1/ITPR2/ATP1B1/LYZ/PRKACA/CALM3/PRKACB	-1.12844744139521
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/1050	82/9376	0.653379790940766	DUT/ITPA/GSTP1/GSTA4/TK1/IMPDH2	-1.1194934487569
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	6/1050	83/9376	0.645507745266781	RBBP7/BMI1/PHF19/L3MBTL2/UBE2D4/SCML1	-1.15194014281673
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/1050	35/9376	0.510258503401361	AKR1B1/TIGAR	-1.03078080986033
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/1050	60/9376	0.595301587301587	BAD/MAP2K2/AKT1/MAPK14	-1.1167461675439
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	11/1050	139/9376	0.706652963343611	ITPR2/PRKACA/KRT19/MAP2K2/KCNJ5/CALM3/AKT1/PRKACB/KRT23/GRB2/CREB3L1	-1.23733049951626
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/1050	36/9376	0.496084656084656	ST6GALNAC1/ST3GAL2	-1.0757156309354
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/1050	49/9376	0.546705539358601	GXYLT2/EOGT/MFNG	-1.12971669807998
Cellular Processes	Cell motility	hsa04814	Motor proteins	16/1050	194/9376	0.736455571919489	TNNT3/ACTB/DNAH8/CAPZB/TNNT1/TUBB/TUBA1B/CAPZA1/KIF1B/DCTN5/DYNLL2/MYO1F/CAPZA2/TUBB2A/DNALI1/KIF26B	-1.31718914767005
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	6/1050	86/9376	0.622990033222591	AREG/BAD/MAP2K2/AKT1/MAPK9/GRB2	-1.24725796093929
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/1050	37/9376	0.482676962676963	ADH5/COMT	-1.11963013112412
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/1050	23/9376	0.38824016563147	ATP1B1	-1.04311332899753
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/1050	51/9376	0.525266106442577	PLAAT3/PLA2G2A/PLD4	-1.20718266802929
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	18/1050	217/9376	0.740697827518104	ADRB1/JAG1/BAD/PRKACA/MAP2K2/XIAP/PAQR7/KPNA2/AKT1/FGF10/ARNT/FGF7/PRKACB/GSTA4/DLL4/GRB2/CREB3L1/ARRB2	-1.37237904219576
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	12/1050	154/9376	0.695807050092764	ITPR2/ACTB/RYR1/PRKACA/RGS2/MAP2K2/KCNJ5/CALM3/RYR2/TRPM2/PRKACB/PPP1CB	-1.35163375907834
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/1050	99/9376	0.631380471380471	LAMA2/ACTB/SLC8A1/TGFB1/RYR2/ITGA3/SGCB	-1.30934544852497
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/1050	134/9376	0.66638237384506	ITPR2/KCNMB4/PLA2G2A/PRKACA/MAP2K2/CALM3/PRKACB/GNA13/PPP1CB/EDNRA	-1.38127607465015
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1050	39/9376	0.457924297924298	CD28/CD86	-1.2046216092045
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/1050	54/9376	0.496084656084656	CGA/CD28/CD86	-1.31874855761825
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/1050	93/9376	0.576098310291859	ACTB/PTPRJ/WASL/WAS/ACP1/CDH5	-1.45889666403627
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1050	27/9376	0.330723104056437	HMGCLL1	-1.23670814098197
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/1050	83/9376	0.537923121055651	HMGCLL1/ECH1/ACAA1/PEX2/PXMP4	-1.50154170878584
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/1050	28/9376	0.31891156462585	FUT9	-1.28169666554266
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/1050	44/9376	0.405887445887446	CD28/CD86	-1.40271611743971
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/1050	45/9376	0.396867724867725	CD28/CD86	-1.44018013399949
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/1050	73/9376	0.489288975864318	HPGDS/ADH5/GSTP1/GSTA4	-1.55556168179809
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/1050	47/9376	0.379979736575481	MAPK9/IRS1	-1.51321051402423
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/1050	48/9376	0.372063492063492	ATP1B1/AKT1	-1.54883148293128
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/1050	102/9376	0.525266106442577	ITPR2/ATP1B1/PLA2G2A/KCNQ1/RYR2/TRPC1	-1.71190185991905
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/1050	32/9376	0.279047619047619	AKR1B1	-1.45069875777577
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/1050	90/9376	0.496084656084656	SLC2A1/ATP1B1/SCARB1/PRKACA/PRKACB	-1.70579399840738
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/1050	79/9376	0.45212778782399	HPGDS/ADH5/GSTP1/GSTA4	-1.73653478979648
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/1050	34/9376	0.262633053221288	BHLHE41	-1.52955563212971
Human Diseases	Substance dependence	hsa05034	Alcoholism	13/1050	191/9376	0.607768636250312	GNGT1/GNG2/GRIN2C/PRKACA/CALM3/HDAC9/GNB2/PRKACB/PPP1CB/GNG7/GRB2/CREB3L1/BDNF	-1.94482937573443
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/1050	82/9376	0.435586527293844	LGMN/CD4/CTSB/HSPA2	-1.82290924928931
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/1050	36/9376	0.248042328042328	ENPP1	-1.60521530311359
NA	NA	hsa04382	Cornified envelope formation	14/1050	217/9376	0.576098310291859	S100A9/OCLN/COL4A1/CLDN11/KRT7/S100A11/PKP2/KRT1/KRT19/COL4A2/S100A8/KRT23/PPP2R2A/S100A4	-2.24353613908668
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/1050	68/9376	0.262633053221288	ADH5/DHRS9	-2.1670654070034
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	7/1050	183/9376	0.341566484517304	RRP7A/POP7/UTP14A/RPP30/NMD3/POP4/AK6	-3.19426489367699
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	17/1050	323/9376	0.469974937343358	ZEB2/IGF2BP1/CDK6/FGFR3/MAP2K2/TP53/BMI1/PDGFRA/EZR/PDGFRB/NOTCH3/RPS6KA5/PIM1/GRB2/ATM/SIRT1/IRS1	-3.44241710851705
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	10/1050	449/9376	0.198875808675363	PDE1C/SLC8A1/GRK3/PRKACA/RGS2/CALM3/PRKACB/GNG7/OR9Q1/ARRB2	-6.17777851228967