category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	157/1861	275/9376	2.87632651067364	C1QA/CYBA/C1QC/CYBB/MT-CYB/MT-CO2/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/C1QB/MT-ND2/ATP5F1E/COX6C/TUBA1B/RYR2/NDUFA4/UQCR10/EGR1/COX4I1/NDUFS5/COX5B/UQCRB/COX7B/COX6B1/NDUFB2/HSPA1A/ATP5MC2/COX7C/COX8A/MT-ND4/NDUFC2/ATP5MC3/NCF4/SLC25A6/ATP5F1D/UQCRQ/NDUFA13/NDUFB7/MT-ND3/COX7A2/PSMA7/NDUFS6/UQCR11/NDUFB10/NDUFA2/NDUFB11/UQCRH/NDUFA1/COX4I2/SLC25A5/ATP5PF/NDUFB4/NDUFB8/ATP5MC1/MT-ND5/TUBA1A/NDUFV2/NDUFA4L2/COX6A1/ATP5PD/NDUFC1/NDUFB3/NDUFA3/NDUFA11/PSMB3/PSMA1/NDUFA12/PSMB4/PSMB6/NDUFB1/ATP5PO/ATP5F1C/PSMB1/PSMA4/PSMA2/NDUFS8/ATP5F1B/NDUFAB1/NDUFB5/NDUFA6/COX5A/NCF1/HSPA8/NDUFA7/PRNP/PSMC4/TUBB/PIK3CD/BAX/ITPR2/PSMB2/CREB1/RAC2/SEM1/COX7A2L/CYCS/TUBB2A/VDAC3/ATP5F1A/PPP3R1/NCF2/NDUFB6/PSMA3/NDUFS7/IL1B/NDUFS4/NDUFA5/NDUFS3/GRIN2C/PSMD4/PSMC5/VDAC2/NDUFB9/ATP5PB/CCL5/KIF5B/UQCRFS1/NCAM2/RYR1/PSMA6/TNF/PSMC2/NDUFV3/PSMA5/PRKACB/CYC1/PRKACA/ADRM1/UQCRC2/EIF2S1/PSMB5/VDAC1/PSMD13/SDHD/NDUFA8/PIK3R2/HSPA6/NDUFA9/COX7B2/PSMD2/PIK3R3/NDUFV1/C9/PSMD6/ITPR1/SDHC/SLC25A4/CREB3L1/MAPK10/NOTCH1/PSMC6/COX7A1/PSMD9/PSMD11/MAPK13/DDIT3	15.7153673358653
Genetic Information Processing	Translation	hsa03010	Ribosome	137/1861	222/9376	3.10912954867818	RPS23/RPS11/RPS18/RPL28/RPL32/RPL26/RPS4X/RPL10/RPL30/RPS27A/RPL13A/RPS14/RPS15A/RPL39/RPLP1/RPS9/RPS12/RPL13/FAU/UBA52/RPS15/RPL27A/RPL14/RPS2/RPL11/RPL19/RPS19/RPL23/RPL23A/RPL15/RPL29/RPL35/RPS7/RPL41/RPS8/RPS25/RPL7A/RPL17/RPL21/RPL24/RPL18/RPS24/RPL34/RPLP2/RPL12/RPL22/RPL3/RPL36A/RPL7/RPL35A/RPL10A/RPL9/RPS16/RPL36AL/RACK1/RPL18A/RPL36/RPL27/RPS17/RPS6/RPL37/RPS13/RPL38/RPLP0/RPL31/RPS5/RPS20/RPL6/RPL5/RPL37A/RPL8/RPS26/RPS3A/RPS21/RPSA/RPS10/RPS27L/RPS28/MRPS21/MRPL14/RPL4/RPL22L1/MRPL51/RPS3/MRPS6/MRPL54/MRPL20/MRPL40/RPL26L1/MRPL52/RSL24D1/MRPL41/MRPL16/MRPS18C/MRPL27/MRPL55/MRPL36/MRPS16/MRPS24/MRPL18/MRPL47/MRPL11/MRPS34/MRPL21/MRPS23/MRPL43/MRPL19/MRPL33/MRPS17/MRPL22/MRPS26/MRPS15/MRPS12/MRPL34/MRPL35/MRPS7/MRPS25/MRPL13/MRPL2/MRPL32/MRPL50/MRPL42/MRPL4/MRPL17/MRPS33/MRPL15/MRPS18A/MRPL9/MRPS14/MRPL12/MRPS11/MRPL44/MRPS22/MRPL38/MRPL24/MRPS9/MRPS10	15.8259074496529
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	151/1861	268/9376	2.83866000465165	MT-CYB/MT-CO2/MT-ATP6/MT-CO1/MT-CO3/RPS27A/MT-ND1/UBA52/MT-ND2/ATP5F1E/UBB/COX6C/TUBA1B/NDUFA4/CALM2/UQCR10/COX4I1/NDUFS5/COX5B/UQCRB/GNAI2/COX7B/COX6B1/NDUFB2/ATP5MC2/COX7C/COX8A/MT-ND4/NDUFC2/ATP5MC3/SLC25A6/ATP5F1D/UQCRQ/NDUFA13/NDUFB7/MT-ND3/COX7A2/PSMA7/NDUFS6/UQCR11/NDUFB10/NDUFA2/NDUFB11/UQCRH/NDUFA1/COX4I2/SLC25A5/ATP5PF/NDUFB4/NDUFB8/CALM3/ATP5MC1/MT-ND5/TUBA1A/NDUFV2/NDUFA4L2/COX6A1/ATP5PD/NDUFC1/NDUFB3/NDUFA3/NDUFA11/PARK7/PSMB3/CALM1/PSMA1/NDUFA12/PSMB4/PSMB6/NDUFB1/ATP5PO/ATP5F1C/PSMB1/PSMA4/PSMA2/NDUFS8/ATP5F1B/NDUFAB1/NDUFB5/NDUFA6/COX5A/NDUFA7/PSMC4/TUBB/BAX/ITPR2/PSMB2/SEM1/COX7A2L/CYCS/TUBB2A/VDAC3/ATP5F1A/NDUFB6/CALML4/CAMK2D/PSMA3/NDUFS7/NDUFS4/NDUFA5/NDUFS3/TXN2/PSMD4/MAP3K5/PSMC5/VDAC2/NDUFB9/ATP5PB/NFE2L2/KIF5B/UQCRFS1/PRKN/PSMA6/PSMC2/NDUFV3/PSMA5/PRKACB/CYC1/PRKACA/ADRM1/UQCRC2/EIF2S1/PSMB5/GNAI3/VDAC1/PSMD13/SDHD/NDUFA8/UBE2J1/NDUFA9/TP53/SLC39A3/COX7B2/PSMD2/NDUFV1/PSMD6/ITPR1/LRRK2/SDHC/SLC25A4/MAPK10/DAXX/PSMC6/BCL2L1/COX7A1/PSMD9/PSMD11/HTRA2/DDIT3/UBA7/KEAP1	15.1967824919032
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	99/1861	138/9376	3.61432609863795	MT-CYB/MT-CO2/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/MT-ND2/ATP5F1E/COX6C/NDUFA4/UQCR10/COX4I1/NDUFS5/COX5B/ATP5MG/UQCRB/COX7B/COX6B1/NDUFB2/ATP5MC2/ATP5MF/COX7C/COX8A/MT-ND4/NDUFC2/ATP5MC3/ATP5F1D/UQCRQ/NDUFA13/NDUFB7/MT-ND3/COX7A2/NDUFS6/UQCR11/ATP6V1F/NDUFB10/NDUFA2/NDUFB11/UQCRH/NDUFA1/ATP6V1G1/COX4I2/ATP5PF/NDUFB4/NDUFB8/ATP5MC1/MT-ND5/NDUFV2/NDUFA4L2/COX6A1/ATP5PD/NDUFC1/NDUFB3/NDUFA3/NDUFA11/ATP5ME/ATP6V0B/NDUFA12/NDUFB1/ATP5PO/COX17/ATP5F1C/NDUFS8/ATP5F1B/NDUFAB1/ATP6V0C/NDUFB5/NDUFA6/COX5A/NDUFA7/COX7A2L/CYCS/ATP5F1A/NDUFB6/NDUFS7/NDUFS4/NDUFA5/NDUFS3/ATP6V1D/ATP6V1B2/NDUFB9/ATP5PB/UQCRFS1/ATP6V0D1/NDUFV3/CYC1/UQCRC2/PPA1/SDHD/NDUFA8/NDUFA9/COX7B2/NDUFV1/SDHC/ATP6V0A1/COX7A1/COX11/ATP6V1A/PPA2	15.3958848775778
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	126/1861	205/9376	3.09661996566231	CD36/COL3A1/CYBA/CYBB/MT-CYB/MT-CO2/MT-ATP6/COL1A1/MT-CO1/MT-CO3/MT-ND1/MT-ND2/ATP5F1E/COL1A2/COX6C/RYR2/NDUFA4/MMP2/UQCR10/COX4I1/NDUFS5/COX5B/UQCRB/COX7B/COX6B1/NDUFB2/ATP5MC2/COX7C/COX8A/MT-ND4/NDUFC2/ATP5MC3/NCF4/SLC25A6/PRKCB/ATP5F1D/UQCRQ/NDUFA13/NDUFB7/MT-ND3/COX7A2/NDUFS6/UQCR11/NDUFB10/NDUFA2/NDUFB11/UQCRH/NDUFA1/COX4I2/SLC25A5/ATP5PF/NDUFB4/NDUFB8/ATP5MC1/MT-ND5/NDUFV2/NDUFA4L2/COX6A1/ATP5PD/PLCB1/NDUFC1/NDUFB3/NDUFA3/NDUFA11/PRKCA/NDUFA12/NFKB1/NDUFB1/ATP5PO/ATP5F1C/NDUFS8/ATP5F1B/NDUFAB1/NDUFB5/NDUFA6/PPP1CA/COX5A/NCF1/NDUFA7/PIK3CD/RAC2/COX7A2L/VDAC3/ATP5F1A/NCF2/NDUFB6/CAMK2D/NDUFS7/PARP1/PLCB2/NDUFS4/NDUFA5/NDUFS3/MPC2/VDAC2/NDUFB9/MPC1/ATP5PB/UQCRFS1/NDUFV3/AGTR1/CYC1/UQCRC2/VDAC1/PPP1CC/PDHB/SDHD/NDUFA8/PIK3R2/IRS1/AKT1/NDUFA9/COX7B2/PIK3R3/PDK2/TGFB3/NDUFV1/SDHC/SLC25A4/MAPK10/TBC1D4/COX7A1/PTPA/MAPK13/PLCB4/AKT2	15.1036750469879
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	152/1861	308/9376	2.48636049603272	MT-CYB/MT-CO2/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/MT-ND2/ATP5F1E/COX6C/TUBA1B/NDUFA4/UQCR10/COX4I1/NDUFS5/COX5B/UQCRB/COX7B/COX6B1/NDUFB2/ATP5MC2/COX7C/COX8A/MT-ND4/NDUFC2/ATP5MC3/SLC25A6/CLTA/ATP5F1D/UQCRQ/CLTC/NDUFA13/POLR2L/NDUFB7/MT-ND3/COX7A2/PSMA7/NDUFS6/UQCR11/NDUFB10/NDUFA2/NDUFB11/UQCRH/AP2S1/NDUFA1/COX4I2/SLC25A5/ATP5PF/NDUFB4/NDUFB8/ATP5MC1/MT-ND5/TUBA1A/NDUFV2/NDUFA4L2/COX6A1/ATP5PD/PLCB1/NDUFC1/NDUFB3/NDUFA3/NDUFA11/PSMB3/PSMA1/NDUFA12/PSMB4/POLR2K/PSMB6/NDUFB1/ATP5PO/ATP5F1C/PSMB1/PSMA4/PSMA2/AP2M1/NDUFS8/ATP5F1B/NDUFAB1/POLR2J/POLR2I/NDUFB5/NDUFA6/COX5A/NDUFA7/PSMC4/TUBB/BAX/PSMB2/CREB1/SEM1/COX7A2L/CYCS/TUBB2A/VDAC3/ATP5F1A/NDUFB6/DCTN3/POLR2E/PSMA3/NDUFS7/POLR2G/PLCB2/NDUFS4/NDUFA5/NDUFS3/BDNF/PSMD4/MAP3K5/PSMC5/VDAC2/NDUFB9/ATP5PB/DNAH8/KIF5B/UQCRFS1/PSMA6/PSMC2/NDUFV3/PSMA5/DCTN6/CYC1/GRIA4/ADRM1/UQCRC2/PSMB5/VDAC1/PSMD13/TFAM/SDHD/DCTN4/NDUFA8/NDUFA9/HDAC2/TP53/ACTR1A/COX7B2/PSMD2/NDUFV1/PSMD6/ITPR1/SDHC/SLC25A4/DCTN2/CREB3L1/MAPK10/PSMC6/NRBF2/COX7A1/PSMD9/PSMD11/DLG4/PLCB4/TBPL1	13.1989106556768
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	121/1861	227/9376	2.68553451675595	CYBA/HGF/MT-CYB/MT-CO2/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/MT-ND2/ATP5F1E/COX6C/NDUFA4/JUN/UQCR10/COX4I1/NDUFS5/COX5B/UQCRB/COX7B/COX6B1/NDUFB2/ATP5MC2/PTPRJ/COX7C/COX8A/MT-ND4/NDUFC2/ATP5MC3/SLC25A6/ATP5F1D/UQCRQ/NDUFA13/NDUFB7/MT-ND3/COX7A2/NDUFS6/UQCR11/NDUFB10/NDUFA2/NDUFB11/PLD1/HIF1A/UQCRH/NDUFA1/COX4I2/SLC25A5/ATP5PF/NDUFB4/NDUFB8/ATP5MC1/MT-ND5/NDUFV2/NDUFA4L2/COX6A1/ATP5PD/NDUFC1/NDUFB3/NDUFA3/NDUFA11/AKR1A1/GSTO1/NDUFA12/NFKB1/NDUFB1/ATP5PO/ATP5F1C/NDUFS8/ATP5F1B/NDUFAB1/NDUFB5/NDUFA6/COX5A/NCF1/MAP2K2/NDUFA7/MGST2/PIK3CD/COX7A2L/CAT/VDAC3/ATP5F1A/NCF2/NDUFB6/NDUFS7/NDUFS4/NDUFA5/NDUFS3/MAP3K5/VDAC2/NDUFB9/ATP5PB/NFE2L2/UQCRFS1/NDUFV3/PTPN1/CYC1/UQCRC2/ACP1/VDAC1/SDHD/NDUFA8/PIK3R2/AKT1/EPHX1/NDUFA9/COX7B2/HRAS/PIK3R3/AHR/NDUFV1/SDHC/SLC25A4/MAPK10/SLC26A2/CBR1/COX7A1/MAPK13/GSTA4/KEAP1/KRAS/AKT2	12.7925787058156
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	124/1861	238/9376	2.62491928528531	F13A1/C1QA/CCL2/C1QC/RPS23/RPS11/CYBB/NRP1/RPS18/RPL28/RPL32/RPL26/CFD/RPS4X/RPL10/RPL30/RPS27A/RPL13A/RPS14/RPS15A/RPL39/RPLP1/RPS9/RPS12/RPL13/FAU/UBA52/RPS15/RPL27A/C1QB/RPL14/RPS2/RPL11/RPL19/RPS19/RPL23/RPL23A/RPL15/RPL29/RPL35/RPS7/RPL41/RPS8/RPS25/RPL7A/RPL17/RPL21/RPL24/RPL18/RPS24/RPL34/RPLP2/JUN/RPL12/RPL22/RPL3/CXCL8/RPL36A/FCGR2A/RPL7/RPL35A/RPL10A/RPL9/RPS16/RPL36AL/RPL18A/RPL36/RPL27/RPS17/RPS6/RPL37/RPS13/RPL38/RPLP0/RPL31/C3AR1/RPS5/RPS20/RPL6/RPL5/PRKCB/SYK/RPL37A/RPL8/RPS26/RPS3A/RPS21/NLRP3/RPSA/C1R/MMP1/TLR4/RPS10/RPS27L/PRKCA/C2/CASP1/RPS28/NFKB1/RPL4/RPL22L1/TNFRSF1A/RPS3/TLR2/PIK3CD/RPL26L1/RSL24D1/TLR7/IL1B/TNF/AGTR1/TLR8/HBEGF/PIK3R2/PIK3R3/C9/IL6R/TAB2/MAPK10/IRF9/CGAS/MAPK13/IRAK1/NFKBIB	12.6354009343095
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	118/1861	235/9376	2.52979523706083	MT-CYB/MT-CO2/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/MT-ND2/ATP5F1E/PRKG1/COX6C/NDUFA4/UQCR10/COX4I1/NDUFS5/COX5B/ATP5MG/UQCRB/RPS6/COX7B/COX6B1/NDUFB2/ATP5MC2/ATP5MF/COX7C/COX8A/MT-ND4/NDUFC2/ATP5MC3/ATP5F1D/UQCRQ/NDUFA13/NDUFB7/MT-ND3/COX7A2/NDUFS6/UQCR11/NDUFB10/NDUFA2/NDUFB11/ACTB/UQCRH/NDUFA1/COX4I2/ATP5PF/NDUFB4/NDUFB8/ATP5MC1/MT-ND5/NDUFV2/NDUFA4L2/COX6A1/ATP5PD/NDUFC1/NDUFB3/ACTG1/NDUFA3/NDUFA11/ATP5ME/NDUFA12/NDUFB1/ATP5PO/NDUFAF3/COX17/ATP5F1C/NDUFS8/ATP5F1B/NDUFAB1/NDUFB5/NDUFA6/NDUFAF8/COX14/COX5A/NDUFA7/CREB1/COX16/COX7A2L/ATP5F1A/NDUFB6/NDUFS7/COA3/NDUFS4/NDUFA5/NDUFS3/MAP3K5/COA4/NDUFB9/ATP5PB/UQCRFS1/COX20/NDUFV3/PRKACB/CYC1/PRKACA/UQCRC2/SDHD/NDUFA8/COA1/COA6/RPS6KA3/NDUFA9/COX7B2/HRAS/NDUFV1/SDHC/CREB3L1/COX7A1/NDUFAF4/PRKAG1/COA5/RPS6KB2/COX11/ACTL6A/ADCY4/MAPK13/SIRT6/NDUFAF6/KRAS/MLST8	11.818564056231
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	165/1861	388/9376	2.14251289352249	CYBB/MT-CYB/MT-CO2/MT-ATP6/WNT2/MT-CO1/MT-CO3/MT-ND1/MT-ND2/ATP5F1E/COX6C/TUBA1B/NDUFA4/CALM2/UQCR10/APOE/COX4I1/NDUFS5/COX5B/UQCRB/COX7B/COX6B1/NDUFB2/ATP5MC2/COX7C/COX8A/MT-ND4/NDUFC2/ATP5MC3/SLC25A6/ATP5F1D/UQCRQ/NDUFA13/NDUFB7/MT-ND3/COX7A2/PSMA7/NDUFS6/UQCR11/NDUFB10/NDUFA2/NDUFB11/UQCRH/NDUFA1/COX4I2/SLC25A5/ATP5PF/NDUFB4/NDUFB8/CALM3/ATP5MC1/MT-ND5/TUBA1A/NDUFV2/NDUFA4L2/COX6A1/ATP5PD/PLCB1/NDUFC1/NDUFB3/NDUFA3/NDUFA11/PSMB3/CALM1/PSMA1/NDUFA12/PSMB4/NFKB1/PSMB6/NDUFB1/ATP5PO/ATP5F1C/PSMB1/BID/PSMA4/PSMA2/NDUFS8/ATP5F1B/NDUFAB1/TNFRSF1A/NDUFB5/NDUFA6/COX5A/MAP2K2/LRP1/NDUFA7/PSMC4/TUBB/PIK3CD/ITPR2/PSMB2/PSENEN/SEM1/LRP6/COX7A2L/CYCS/TUBB2A/VDAC3/ATP5F1A/PPP3R1/NDUFB6/CALML4/PSMA3/NDUFS7/IL1B/PLCB2/NDUFS4/NDUFA5/NDUFS3/CSF1/GRIN2C/PSMD4/MAP3K5/PSMC5/VDAC2/NDUFB9/ATP5PB/KIF5B/HSD17B10/UQCRFS1/PSMA6/TNF/PSMC2/NDUFV3/PSMA5/CYC1/ADRM1/FZD2/UQCRC2/EIF2S1/PSMB5/VDAC1/PSMD13/SDHD/NDUFA8/PIK3R2/IRS1/AKT1/NDUFA9/SLC39A3/COX7B2/HRAS/PSMD2/PIK3R3/NDUFV1/PSMD6/ITPR1/SDHC/SLC25A4/MAPK10/BACE1/DKK2/PSMC6/NRBF2/COX7A1/PSMD9/PSMD11/PPID/CAPN1/DDIT3/FZD7/FZD1/PLCB4/KRAS/AKT2	11.4377282294195
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	191/1861	480/9376	2.00476446355006	CYBB/MT-CYB/MT-CO2/MT-ATP6/WNT2/MT-CO1/MT-CO3/RPS27A/MT-ND1/UBA52/MT-ND2/ATP5F1E/UBB/COX6C/TUBA1B/RYR2/NDUFA4/CALM2/UQCR10/COX4I1/NDUFS5/COX5B/UQCRB/COX7B/COX6B1/NDUFB2/ATP5MC2/COX7C/COX8A/MT-ND4/NDUFC2/ATP5MC3/SLC25A6/PRKCB/ATP5F1D/UQCRQ/NDUFA13/NDUFB7/MT-ND3/COX7A2/PSMA7/NDUFS6/UQCR11/NDUFB10/NDUFA2/NDUFB11/UQCRH/NDUFA1/COX4I2/SLC25A5/ATP5PF/NDUFB4/NDUFB8/CALM3/ATP5MC1/TNFRSF1B/MT-ND5/TUBA1A/NDUFV2/NDUFA4L2/COX6A1/ATP5PD/PLCB1/NDUFC1/NDUFB3/NDUFA3/NDUFA11/PARK7/PSMB3/CALM1/PRKCA/PSMA1/NDUFA12/PSMB4/NFKB1/PSMB6/TANK/NDUFB1/ATP5PO/ATP5F1C/PSMB1/BID/PSMA4/PSMA2/NDUFS8/ATP5F1B/NDUFAB1/TNFRSF1A/NDUFB5/NDUFA6/COX5A/MAP2K2/NDUFA7/PRNP/PSMC4/TUBB/BAX/ITPR2/PSMB2/SEM1/LRP6/COX7A2L/CYCS/TUBB2A/CAT/VDAC3/ATP5F1A/PPP3R1/NDUFB6/CALML4/DCTN3/CAMK2D/PSMA3/NDUFS7/IL1B/PLCB2/NDUFS4/NDUFA5/NDUFS3/BDNF/CSF1/GRIN2C/C9orf72/PSMD4/MAP3K5/PSMC5/VDAC2/NDUFB9/ATP5PB/DNAH8/VCP/KIF5B/HSD17B10/UQCRFS1/RYR1/PRKN/PSMA6/TNF/PSMC2/NDUFV3/PSMA5/DCTN6/CYC1/GRIA4/ADRM1/FZD2/UQCRC2/EIF2S1/PSMB5/VDAC1/PSMD13/SDHD/DCTN4/NDUFA8/UBE2J1/NDUFA9/ACTR1A/COX7B2/HRAS/PSMD2/NDUFV1/PSMD6/ITPR1/LRRK2/SDHC/SLC25A4/DCTN2/MAPK10/DAXX/DKK2/CCS/PSMC6/NRBF2/BCL2L1/COX7A1/PSMD9/PSMD11/PPID/MAP2K6/MAPK13/HTRA2/CAPN1/DLG4/FIG4/DDIT3/UBA7/FZD7/FZD1/PLCB4/SMCR8/KRAS	11.2455792488937
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	89/1861	157/9376	2.85602220571777	MT-CYB/MT-CO2/MT-CO1/MT-CO3/COX6C/NDUFA4/JUN/UQCR10/CXCL8/COX4I1/NDUFS5/COX5B/UQCRB/COX7B/COX6B1/NDUFB2/COX7C/COX8A/NDUFC2/UQCRQ/NDUFA13/NDUFB7/COX7A2/NDUFS6/UQCR11/NDUFB10/NDUFA2/NDUFB11/UQCRH/NDUFA1/COX4I2/NDUFB4/NDUFB8/NDUFV2/NDUFA4L2/COX6A1/NDUFC1/NDUFB3/NDUFA3/NDUFA11/NDUFA12/NFKB1/NDUFB1/BID/NDUFS8/NDUFAB1/TNFRSF1A/SOCS3/NDUFB5/NDUFA6/COX5A/NDUFA7/PIK3CD/BAX/COX7A2L/CYCS/NDUFB6/NDUFS7/IL1B/NDUFS4/NDUFA5/NDUFS3/MAP3K5/NDUFB9/UQCRFS1/TNF/NDUFV3/ADIPOR1/CYC1/UQCRC2/EIF2S1/SDHD/NDUFA8/PIK3R2/IRS1/AKT1/NDUFA9/COX7B2/PIK3R3/NDUFV1/IL6R/SDHC/MAPK10/COX7A1/PRKAG1/MLX/MAPK13/DDIT3/AKT2	11.6703913273737
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	157/1861	368/9376	2.14942877835666	MT-CYB/MT-CO2/MT-ATP6/MT-CO1/MT-CO3/MT-ND1/MT-ND2/ATP5F1E/COX6C/TUBA1B/NDUFA4/UQCR10/COX4I1/NDUFS5/COX5B/UQCRB/COX7B/COX6B1/NDUFB2/ATP5MC2/COX7C/COX8A/MT-ND4/NDUFC2/ATP5MC3/PFN1/ATP5F1D/UQCRQ/NDUFA13/NDUFB7/MT-ND3/COX7A2/PSMA7/NDUFS6/UQCR11/NDUFB10/NDUFA2/NDUFB11/ACTB/UQCRH/NDUFA1/COX4I2/ATP5PF/NDUFB4/NDUFB8/ATP5MC1/TNFRSF1B/MT-ND5/TUBA1A/NDUFV2/NDUFA4L2/COX6A1/ATP5PD/NDUFC1/NDUFB3/ACTG1/NDUFA3/NDUFA11/PSMB3/CHCHD10/PSMA1/CASP1/NDUFA12/PSMB4/PSMB6/TANK/NDUFB1/ATP5PO/ATP5F1C/PSMB1/SRSF3/BID/PSMA4/PSMA2/NDUFS8/ATP5F1B/NDUFAB1/TNFRSF1A/HNRNPA1/NDUFB5/HNRNPA3/NDUFA6/COX5A/NDUFA7/PSMC4/TUBB/BAX/PSMB2/SEM1/COX7A2L/CYCS/TUBB2A/CAT/ATP5F1A/PPP3R1/NDUFB6/DCTN3/PSMA3/NDUFS7/NDUFS4/NDUFA5/NDUFS3/GRIN2C/C9orf72/PSMD4/MAP3K5/PSMC5/NDUFB9/ATP5PB/DNAH8/VCP/KIF5B/UQCRFS1/PRKN/PSMA6/TNF/PSMC2/NDUFV3/PSMA5/DCTN6/CYC1/ADRM1/UQCRC2/EIF2S1/PSMB5/VDAC1/PSMD13/SDHD/DCTN4/NDUFA8/NDUFA9/TP53/ALYREF/ACTR1A/COX7B2/PSMD2/NDUFV1/NUP54/PSMD6/SDHC/DCTN2/RANBP2/DAXX/CCS/PSMC6/NRBF2/BCL2L1/COX7A1/PSMD9/PSMD11/MAP2K6/MAPK13/NUP160/FIG4/DDIT3/NUP133/SMCR8	11.1940210511388
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	32/1861	46/9376	3.50480106534589	PSMA7/PSMB8/PSMB3/PSMA1/POMP/PSMB4/PSMB6/PSMB1/PSMA4/PSMA2/PSMB10/PSMC4/PSMB2/PSME2/SEM1/PSME1/PSMA3/PSMD4/PSMC5/PSMA6/PSMF1/PSMC2/PSMA5/ADRM1/PSMB9/PSMB5/PSMD13/PSMD2/PSMD6/PSMC6/PSMD9/PSMD11	8.47433573058311
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	66/1861	149/9376	2.23166443674289	GNG2/MT-ND1/MT-ND2/NDUFA4/NDUFS5/GNG11/GNAI2/NDUFB2/MT-ND4/NDUFC2/GNG5/PRKCB/GNG10/NDUFA13/NDUFB7/MT-ND3/NDUFS6/NDUFB10/NDUFA2/NDUFB11/NDUFA1/NDUFB4/NDUFB8/MT-ND5/NDUFV2/NDUFA4L2/PLCB1/NDUFC1/NDUFB3/NDUFA3/NDUFA11/PRKCA/NDUFA12/GNGT1/NDUFB1/NDUFS8/NDUFAB1/GNB4/KCNJ5/GNB2/NDUFB5/NDUFA6/NDUFA7/ITPR2/NDUFB6/NDUFS7/PLCB2/NDUFS4/NDUFA5/NDUFS3/NDUFB9/NDUFV3/GABRA3/PRKACB/PRKACA/GRIA4/GNAI3/NDUFA8/NDUFA9/NDUFV1/ITPR1/GNG7/MAPK10/ADCY4/MAPK13/PLCB4	7.54135886849559
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	89/1861	250/9376	1.79358194519076	LGMN/CTSC/LAPTM5/BLOC1S1/CLTA/ASAH1/CLTC/AP1S2/CD68/ATP6V1F/AP2S1/LAMTOR4/ATP6V1G1/CTSS/VAMP8/LAMTOR5/VPS29/NPC2/LAMTOR2/CTSZ/ATP6V0B/CD63/MANBA/AP2M1/NEU1/ATP6V0C/LAMTOR1/AP1B1/CTSB/SUMF1/OSBPL6/MAN2B1/ARSB/TLR7/HYAL2/PLA2G15/M6PR/DMXL2/ATP6V1D/ATP6V1B2/LITAF/VPS35/GLA/GPR155/FUCA1/CTBS/BORCS7/LAMTOR3/CTSH/ACP2/LIPA/ATP6V0D1/RRAGA/PPT1/MCOLN2/TLR8/NAGA/MCOLN1/BLOC1S2/MITF/CLN6/NPC1/SLC15A3/OSBPL3/LAPTM4B/CTSO/WDR7/GNPTAB/BORCS5/ATP6V0A1/ARL8A/CLCN7/KXD1/NCOA7/PIKFYVE/ATP6V1A/ABCA2/CTSK/GALC/RRAGD/FIG4/SLC36A1/TFEB/VPS11/RRAGB/BLOC1S5/AP4S1/MLST8/TFE3	6.32872001917737
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	40/1861	85/9376	2.37089483832222	ENPP1/NME2/APRT/GUK1/ADA2/TYMP/NME3/NME1/DCK/IMPDH2/DUT/NT5C/NME4/NUDT16/HDDC2/AK1/ITPA/LACC1/TYMS/DTYMK/RRM1/DGUOK/DCTPP1/AK6/IMPDH1/NME6/GMPR/ENTPD8/NTPCR/GMPR2/HPRT1/UCK1/PNP/CTPS2/TK2/CMPK2/AK9/NT5C3A/TK1/RRM2B	6.31795759037519
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	78/1861	224/9376	1.75435633683887	NRP1/CCND2/HLA-C/JUN/EGR1/HLA-A/SPI1/CCND1/SLC25A6/HLA-DRA/CD4/SLC25A5/ICAM1/TSPO/ANAPC11/ITGB2/RB1/HLA-DPA1/RAN/NFKB1/EGR2/TNFRSF1A/HLA-DQA2/RANBP1/MAP2K2/HLA-DMA/PIK3CD/BAX/HLA-DMB/CREB1/MAP3K1/VDAC3/PPP3R1/NFATC2/VDAC2/IL2RA/TNF/PRKACB/CDC26/PRKACA/ANAPC13/MAP3K3/ATM/VDAC1/JAK3/CDK4/ETS1/TLN1/ANAPC15/CDKN2A/PIK3R2/PTTG1/AKT1/LTBR/TP53/HRAS/CDC27/FDPS/PIK3R3/TGFB3/NFATC3/ITGAL/SLC25A4/STAT5A/CREB3L1/MAPK10/BCL2L1/MSX1/RELB/BUB3/ADCY4/CDKN2C/HLA-F/ANAPC10/TBPL1/KRAS/CCNB2/AKT2	5.68639309359442
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	56/1861	144/9376	1.9592811511135	RBPJ/SLC25A6/PRKCB/PSMA7/SLC25A5/SLC1A6/PLCB1/PSMB3/PRKCA/PSMA1/PSMB4/PSMB6/PSMB1/PSMA4/PSMA2/PSMC4/PIK3CD/ITPR2/PSMB2/SEM1/CYCS/VDAC3/PSMA3/GTF2B/PLCB2/GRIN2C/PSMD4/MAP3K5/PSMC5/VDAC2/RYR1/PSMA6/PSMC2/PSMA5/ADRM1/PSMB5/VDAC1/PSMD13/PIK3R2/AKT1/PSMD2/PIK3R3/PSMD6/ITPR1/SLC25A4/MAPK10/NOP56/PSMC6/NRBF2/PSMD9/PSMD11/OMA1/VLDLR/PLCB4/TBPL1/AKT2	5.77262826567831
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	41/1861	95/9376	2.17436013461919	CCL3/CCL2/CCL3L1/JUN/CXCL8/CD86/HLA-DRA/CD28/ATP6V1F/ATP6V1G1/ICAM1/MMP1/TLR4/ITGB2/HLA-DPA1/ATP6V0B/TNFSF13B/ATP6V0C/HLA-DQA2/TNFRSF11A/TLR2/ANGPT1/HLA-DMA/HLA-DMB/IL1B/CSF1/ATP6V1D/ATP6V1B2/CCL5/LTB/TNF/ATP6V0D1/TEK/CXCL12/CXCL1/TGFB3/ITGAL/ATP6V0A1/ATP6V1A/CTSK/TNFSF13	5.72479643804038
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	58/1861	155/9376	1.88524379885944	CD14/CD36/CYBA/FCGR3A/CYBB/TUBA1B/HLA-C/COLEC12/FCGR2A/MRC1/HLA-A/FCGR1A/MSR1/NCF4/CLEC7A/HLA-DRA/SEC61B/ATP6V1F/ACTB/CD209/ATP6V1G1/CTSS/C1R/TUBA1A/TLR4/SEC61G/ITGB2/ACTG1/HLA-DPA1/CORO1A/ATP6V0B/ITGB5/RAB5C/ATP6V0C/ITGAM/HLA-DQA2/TLR2/NCF1/HLA-DMA/TUBB/HLA-DMB/TUBB2A/NCF2/M6PR/ATP6V1D/ATP6V1B2/STX7/ATP6V0D1/FCGR2B/STX12/EEA1/VAMP3/ATP6V0A1/DYNC2H1/PIKFYVE/ATP6V1A/TLR6/HLA-F	5.53011373849548
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	82/1861	248/9376	1.66584042571632	CD14/LY96/TUBA1B/PTPRC/JUN/CXCL8/S100A10/DYNLL1/ARPC3/PYCARD/PFN1/CYTH4/ACTB/NLRP3/ARPC5/NCKAP1L/TUBA1A/RHOG/TLR4/MYL12A/ACTG1/BRK1/DYNLRB1/CASP1/ELMO1/NFKB1/RAB5C/TNFRSF1A/RPS3/MYL12B/HSP90AB1/TLR2/MAP2K2/TUBB/PIK3CD/BAX/ACTR2/CYCS/ARPC4/TUBB2A/PIK3CG/DCTN3/M6PR/DYNLT1/ARPC1B/IL1B/TXN2/TNFRSF10B/KIF5B/LEF1/TNF/DCTN6/RAB9A/CYFIP1/SNX18/DYNLT3/DCTN4/PKN1/AKT1/ACTR1A/HRAS/CASP4/TLR5/RIPK2/TAB2/DCTN2/MAPK10/STX10/MAP2K6/ARL8A/DYNC2H1/MAPK13/TLR6/NAIP/PLEKHM2/EXOC7/IRAK1/RIPK1/NLRC4/TCF7/VPS11/AKT2	5.28813478877575
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	73/1861	216/9376	1.70270861942006	CD14/CD36/CCL3/CCL2/CYBA/CYBB/CCL3L1/LY96/CALM2/JUN/CXCL8/VCAM1/HSPA1A/PYCARD/NCF4/POU2F2/ICAM1/NLRP3/CALM3/MMP1/LYN/TLR4/PLCB1/CALM1/PRKCA/CASP1/NFKB1/TANK/BID/VAV1/TNFRSF1A/HSP90AB1/TLR2/NCF1/HSPA8/PIK3CD/BAX/CYCS/PPP3R1/NCF2/CALML4/CAMK2D/NFATC2/IL1B/PLCB2/TNFRSF10B/MAP3K5/NFE2L2/CCL5/TNF/EIF2S1/CXCL1/MIB1/PIK3R2/AKT1/HSPA6/TP53/HRAS/PIK3R3/NFATC3/ITPR1/TAB2/MAPK10/BCL2L1/MAP2K6/MAPK13/TLR6/VLDLR/IRAK1/DDIT3/PLCB4/KRAS/AKT2	5.19934638731821
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	63/1861	181/9376	1.75361075403529	CD14/FCER1G/FCGR3A/CR1/CALM2/FCGR2A/CD74/MRC1/FCGR1A/CLEC7A/HLA-DRA/SYK/CD209/CTSS/CALM3/TLR4/ITGB2/TLR1/HLA-DPA1/CALM1/CORO1A/ATP6V0B/NFKB1/RAB5C/BID/ATP6V0C/TNFRSF1A/ITGAM/HLA-DQA2/TLR2/LSP1/HLA-DMA/IL10RA/BAX/HLA-DMB/CREB1/CYCS/PPP3R1/CALML4/CAMK2D/IL1B/TNF/ATP6V0D1/IRAK2/RFXANK/CASP10/FCGR2B/AKT1/IL10RB/TGFB3/EEA1/ITGAX/BCL10/RIPK2/MAPK10/ATP6V0A1/MAPK13/MALT1/TLR6/IRAK1/NFYC/CR1L/AKT2	5.09453840107591
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	25/1861	50/9376	2.51907576571736	CD36/CCL2/HGF/HBB/HBA2/HBA1/CR1/CXCL8/CD81/VCAM1/PECAM1/GYPC/ICAM1/TLR4/ITGB2/TLR2/LRP1/IL1B/KLRB1/TNF/SDC2/TGFB3/ITGAL/GYPB/CR1L	5.35933696959139
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	74/1861	227/9376	1.64239301024744	CCL3/CCL2/CCL4/CCL4L2/GNG2/CCL3L1/HLA-C/CALM2/CDK6/CXCL8/HLA-A/GNG11/GNAI2/CCND1/GNG5/PRKCB/GNG10/CALM3/PLCB1/RB1/CALM1/PRKCA/NFKB1/GNGT1/BID/TNFRSF1A/GNB4/GNB2/CCR1/MAP2K2/IL10RA/PIK3CD/BAX/ITPR2/EIF4EBP1/CREB1/PTGER4/RAC2/CYCS/PPP3R1/CALML4/NFATC2/IL1B/PLCB2/GNA13/CCL5/TNF/PRKACB/PRKACA/GNAI3/CXCL12/CDK4/CDKN2A/PIK3R2/AKT1/IL10RB/TP53/HRAS/PIK3R3/IL6R/NFATC3/ITPR1/GNG7/CREB3L1/CGAS/MAP2K6/RPS6KB2/ADCY4/MAPK13/HLA-F/RIPK1/PLCB4/KRAS/AKT2	4.87552349830996
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	50/1861	137/9376	1.83874143483019	CTSC/TUBA1B/JUN/ACTB/CTSS/TUBA1A/ACTG1/CTSZ/PMAIP1/NFKB1/BCL2A1/BID/TNFRSF1A/CTSB/MAP2K2/PIK3CD/BAX/ITPR2/CYCS/PARP1/TNFRSF10B/MAP3K5/GZMB/CTSH/TNF/EIF2S1/ATM/CASP10/SPTAN1/PIK3R2/AKT1/PRF1/TP53/HRAS/PIK3R3/ITPR1/CTSO/MAPK10/DAXX/BCL2L1/BIRC5/HTRA2/CAPN1/CTSK/DFFA/DDIT3/LMNB2/RIPK1/KRAS/AKT2	4.92119110713595
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	51/1861	142/9376	1.80947695847303	TYROBP/CYBA/FCGR3A/JUN/FCGR2A/FCGR1A/JUNB/SPI1/LCP2/NCF4/SYK/LILRB5/NFKB1/SIRPA/TNFRSF1A/SOCS3/TNFRSF11A/NCF1/PIK3CD/ITPR2/CSF1R/CREB1/PPP3R1/NCF2/TEC1/NFATC2/IL1B/CSF1/TNF/LILRB1/FCGR2B/PIK3R2/AKT1/LILRB2/MITF/PIK3R3/CYLD/ITPR1/BTK/TAB2/MAPK10/LILRB3/IRF9/BLNK/RELB/MAP2K6/MAPK13/CTSK/LILRB4/TMEM64/AKT2	4.83668785864847
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	50/1861	140/9376	1.79933983265525	SPP1/MEF2C/GNG2/RYR2/CALM2/EGR1/GNG11/GNAI2/RPS6/CCND1/KLF2/GNG5/GNG10/SLC8A1/CALM3/PLCB1/CALM1/MEF2A/PDE3B/GNGT1/GNB4/GNB2/PIK3R5/MAP2K2/ITPR2/PIK3CG/CALML4/APLNR/PLCB2/GNA13/RYR1/APLN/AGTR1/PRKACB/PRKACA/GNAI3/TFAM/AKT1/HRAS/NOTCH3/ITPR1/MEF2D/GNG7/MYL4/PRKAG1/RPS6KB2/ADCY4/PLCB4/KRAS/AKT2	4.74185034438385
Organismal Systems	Immune system	hsa04611	Platelet activation	46/1861	126/9376	1.83932516226982	COL3A1/FCER1G/COL1A1/PRKG1/COL1A2/FCGR2A/GNAI2/LCP2/SYK/GUCY1A2/TBXAS1/ACTB/GUCY1A1/VAMP8/LYN/PLCB1/MYL12A/ACTG1/FERMT3/MYL12B/PIK3R5/PPP1CA/PIK3CD/ITPR2/PIK3CG/PLCB2/GNA13/APBB1IP/GUCY1B1/PRKACB/PRKACA/GNAI3/PPP1CC/TLN1/PIK3R2/AKT1/P2RY1/PIK3R3/PLA2G4C/ITPR1/BTK/PTGS1/ADCY4/MAPK13/PLCB4/AKT2	4.71996721025354
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	35/1861	87/9376	2.02684257011741	MT-CYB/MT-CO2/MT-CO1/MT-CO3/COX6C/RYR2/UQCR10/COX4I1/ATP1B3/COX5B/UQCRB/ATP1B1/COX7B/COX6B1/COX7C/COX8A/UQCRQ/COX7A2/UQCR11/UQCRH/COX4I2/SLC8A1/COX6A1/TPM3/COX5A/CACNB4/COX7A2L/UQCRFS1/CYC1/UQCRC2/COX7B2/CACNA2D4/MYL4/CACNA2D1/COX7A1	4.78821168577878
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	50/1861	142/9376	1.77399701811081	CCL2/CYBA/MEF2C/CALM2/MMP2/JUN/VCAM1/KLF2/SUMO2/PECAM1/BMP4/ACTB/ICAM1/CALM3/ACTG1/CALM1/MEF2A/GSTO1/NFKB1/TNFRSF1A/ACVR2A/HSP90AB1/SUMO1/NCF1/MGST2/PIK3CD/SUMO3/RAC2/NCF2/CDH5/CALML4/IL1B/KDR/TXN2/MAP3K5/NFE2L2/TNF/SDC2/PIK3R2/AKT1/MAP2K5/TP53/PIK3R3/MAPK10/MAP2K6/MAPK13/GSTA4/KEAP1/BMPR1A/AKT2	4.62469245225764
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	64/1861	196/9376	1.64511070414195	RPS27A/GNG2/UBA52/UBB/HLA-C/CALM2/CDK6/JUN/CXCL8/CD86/HLA-A/GNG11/CCND1/GNG5/GNG10/SYK/HIF1A/ICAM1/CALM3/HCK/LYN/CD200R1/RB1/CALM1/NFKB1/GNGT1/BID/TNFRSF1A/GNB4/GNB2/CCR1/PIK3R5/MAP2K2/PREX1/PIK3CD/BAX/ITPR2/CREB1/CYCS/PIK3CG/PPP3R1/CALML4/NFATC2/CLEC2B/LEF1/CXCL1/CDK4/PIK3R2/AKT1/TP53/HRAS/PIK3R3/NFATC3/ITPR1/GNG7/MAPK10/IRF9/FGF2/MAP2K6/MAPK13/HLA-F/TCF7/KRAS/AKT2	4.54187602410604
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	32/1861	78/9376	2.06693396161424	CYBA/FCGR3A/CYBB/CR1/JUN/FCGR2A/FCGR1A/NCF4/PRKCB/HLA-DRA/TLR4/ITGB2/HLA-DPA1/NFKB1/EEF1A1/ITGAM/HLA-DQA2/TLR2/NCF1/HLA-DMA/HLA-DMB/NCF2/IL1B/MARCKSL1/ITGA4/TNF/TGFB3/TAB2/MAPK13/IRAK1/NFKBIB/CR1L	4.70851981179553
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	46/1861	128/9376	1.81058570660935	ENPP1/PDE4D/PDE4B/NME2/PDE3A/GUCY1A2/APRT/GUCY1A1/GUK1/PDE3B/ADA2/NME3/NME1/DCK/IMPDH2/NT5C/NME4/NUDT16/GUCY1B1/HDDC2/AK1/PDE1C/ITPA/LACC1/RRM1/DGUOK/NUDT5/AK6/IMPDH1/PDE9A/NUDT9/NME6/PRPS2/GMPR/ENTPD8/NTPCR/PRPS1/GMPR2/HPRT1/PNP/ADCY4/NUDT2/PDE5A/HDDC3/AK9/RRM2B	4.59488184247195
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	26/1861	59/9376	2.22020236978479	ENPP1/NME2/DPYD/TYMP/NME3/NME1/DCK/DUT/NT5C/NME4/HDDC2/TYMS/DTYMK/RRM1/DCTPP1/NME6/ENTPD8/UCK1/CTPS2/NUDT2/TK2/CMPK2/AK9/NT5C3A/TK1/RRM2B	4.67858101829819
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	25/1861	56/9376	2.24917479081907	CD14/CR1/CXCL8/HSPA1A/PYCARD/TLR4/EEF1G/ITGB2/CASP1/NFKB1/EEF1A1/ITGAM/TLR2/HSPA8/CYCS/IL1B/VCP/TNF/RAB1B/CXCL1/HSPA6/TLR5/NAIP/CR1L/NLRC4	4.66555808791631
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	53/1861	157/9376	1.7007772685735	CCND2/HLA-C/CALM2/CDK6/CXCL8/HLA-A/CCND1/SLC25A6/SLC25A5/CALM3/RB1/CALM1/NFKB1/PPP1CA/MAP2K2/PIK3CD/ITPR2/EIF4EBP1/GATA4/VDAC3/PPP3R1/CALML4/NFATC2/VDAC2/ATM/VDAC1/CDK4/ETS1/PPP1CC/CDKN2A/PIK3R2/AKT1/TP53/HRAS/PIK3R3/RASSF5/CDK1/TGFB3/NFATC3/ITPR1/SLC25A4/E2F4/PPID/MAP2K6/MAPK13/HIPK1/CAPN1/HLA-F/RBL1/SIRT1/KRAS/CCNB2/AKT2	4.40638314153038
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	31/1861	78/9376	2.0023422753138	CD14/C1QA/C1QC/C1QB/LY96/CALM2/JUN/CXCL8/GNAI2/PYCARD/NLRP3/CALM3/C1R/TLR4/ITGB2/CFL1/CALM1/C2/CASP1/NFKB1/ITGAM/CALML4/IL1B/C4BPB/TNF/GNAI3/IRF8/IRF1/MAPK10/MAPK13/IRAK1	4.42346821013615
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	37/1861	101/9376	1.84565947191173	COL3A1/CCL2/CYBB/COL1A1/COL1A2/MMP2/JUN/CXCL8/EGR1/VCAM1/CCND1/PRKCB/ICAM1/PLCB1/PRKCA/NFKB1/PIK3CD/BAX/IL1B/PLCB2/VEGFB/TNF/AGTR1/CDK4/PIK3R2/AKT1/HRAS/PIK3R3/TGFB3/CDKN1B/STAT5A/MAPK10/VEGFC/MAPK13/PLCB4/KRAS/AKT2	4.25200315061505
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	38/1861	105/9376	1.82333103042399	CD14/CCL4/CCL4L2/LY96/EDA/CXCL8/VCAM1/PRKCB/SYK/ICAM1/LYN/TLR4/PLAU/NFKB1/BCL2A1/TNFSF13B/TNFRSF1A/TNFRSF11A/UBE2I/CCL13/IL1B/PARP1/LTB/TNF/CXCL12/ATM/CXCL1/LTBR/CYLD/BCL10/BTK/TAB2/BCL2L1/BLNK/RELB/MALT1/IRAK1/RIPK1	4.22182449260865
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	38/1861	105/9376	1.82333103042399	FCER1G/CALM2/JUN/PYCARD/CLEC7A/SYK/CD209/NLRP3/CALM3/CALM1/CASP1/NFKB1/EGR2/LSP1/PIK3CD/ITPR2/PPP3R1/CALML4/NFATC2/IL1B/TNF/PIK3R2/AKT1/HRAS/PIK3R3/EGR3/IRF1/NFATC3/CYLD/ITPR1/BCL10/MAPK10/IRF9/RELB/MAPK13/MALT1/KRAS/AKT2	4.22182449260865
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	34/1861	91/9376	1.88238628647011	JUN/CD81/PRKCB/SYK/LILRB5/INPP5D/LYN/NFKB1/PIK3AP1/VAV1/MAP2K2/PIK3CD/RAC2/PPP3R1/NFATC2/LILRB1/FCGR2B/PIK3R2/AKT1/LILRB2/HRAS/RASGRP3/PIK3R3/NFKBIE/NFATC3/BCL10/BTK/LILRB3/BLNK/MALT1/LILRB4/NFKBIB/KRAS/AKT2	4.20903778389201
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	65/1861	212/9376	1.54471627143045	HGF/CALM2/PDGFC/IGF1/GNAI2/DOCK4/LCP2/PFN1/MAGI1/PRKCB/ACTB/CALM3/FGF7/KITLG/ITGB2/PLCB1/FYB1/ACTG1/CALM1/PRKCA/FPR1/VAV1/MAGI3/ITGAM/ANGPT1/MAP2K2/ENAH/PIK3CD/CSF1R/RAC2/EFNA5/CALML4/SIPA1L2/ID1/PLCB2/KDR/CSF1/LPAR5/APBB1IP/VEGFB/RAPGEF5/SIPA1/TEK/GNAI3/RAPGEF6/TLN1/PIK3R2/AKT1/P2RY1/HRAS/RASGRP3/PIK3R3/RASSF5/FGF10/ITGAL/VEGFC/FGF2/PDGFRB/MAP2K6/ADCY4/MAPK13/FGFR3/PLCB4/KRAS/AKT2	3.99199575645622
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	63/1861	205/9376	1.54830998283116	CCND2/VIM/HLA-C/RBPJ/CDK6/JUN/HLA-A/CCND1/HLA-DRA/SYK/ICAM1/LYN/RB1/HLA-DPA1/NFKB1/BID/HLA-DQA2/TLR2/HLA-DMA/PSMC4/PIK3CD/BAX/HLA-DMB/SEM1/CYCS/PSMD4/PSMC5/CD247/TNF/PSMC2/ADRM1/JAK3/CDK4/PSMD13/CD58/PIK3R2/AKT1/HDAC2/TP53/PSMD2/PIK3R3/NFKBIE/PSMD6/CDKN1B/ITGAL/BTK/TAB2/MAPK10/IRF9/PSMC6/PSMD11/ENTPD8/BLNK/RELB/MAP2K6/POLK/DDB2/MAPK13/HLA-F/IRAK1/NFKBIB/RIPK1/AKT2	3.94992699742092
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	46/1861	138/9376	1.67938384381157	CCL2/JUN/CXCL8/FCGR2A/ARPC3/LCP2/PYCARD/CD4/ACTB/NLRP3/ARPC5/RHOG/TLR4/FYB1/ACTG1/WAS/CASP1/WASF2/ELMO1/NFKB1/VAV1/MAP2K2/PIK3CD/ACTR2/RAC2/ARPC4/NFATC2/ARPC1B/IL1B/ITGA4/TNF/SKAP2/PKN1/PIK3R2/AKT1/RPS6KA3/PIK3R3/NFATC3/TAB2/MAPK10/GIT2/MAP2K6/MAPK13/IRAK1/NLRC4/AKT2	4.00092224625641
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	50/1861	154/9376	1.63576348423205	MEF2C/RYR2/CALM2/JUN/GNAI2/CCND1/MYL6/PRKCB/GUCY1A2/ACTB/CALM3/GUCY1A1/PLCB1/ACTG1/CALM1/PRKCA/TRPM2/KCNJ5/PIK3R5/PPP1CA/MAP2K2/EEF2/CACNB4/ITPR2/PIK3CG/PPP3R1/CALML4/CAMK2D/NFATC2/PLCB2/RGS2/RYR1/GUCY1B1/PRKACB/PRKACA/GNAI3/CD38/PPP1CC/MAP2K5/HRAS/CACNA2D4/NFATC3/PLA2G4C/ITPR1/CACNA2D1/MYL6B/PRKAG1/ADCY4/PLCB4/KRAS	3.9585643930322
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	35/1861	97/9376	1.81788972783727	GNG2/PRKG1/RYR2/CALM2/GNG11/GNAI2/GNG5/PRKCB/GNG10/GUCY1A2/CALM3/GUCY1A1/PLCB1/CALM1/PRKCA/GNGT1/GNB4/KCNJ5/GNB2/CREB1/CALML4/CAMK2D/PLCB2/PER3/GRIN2C/RYR1/GUCY1B1/PRKACB/PRKACA/GRIA4/GNAI3/ITPR1/GNG7/ADCY4/PLCB4	4.02925140334661
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	65/1861	214/9376	1.53027967076288	GNG2/HLA-C/CALM2/JUN/HLA-A/GNG11/GNAI2/ELOB/GNG5/PRKCB/GNG10/AP1S2/CD4/CALM3/TNFRSF1B/TLR4/CFL1/CALM1/PRKCA/RNF7/NFKB1/GNGT1/RBX1/ELOC/BID/TNFRSF1A/GNB4/AP1B1/GNB2/TLR2/MAP2K2/PIK3CD/BAX/ITPR2/APOBEC3C/RAC2/CYCS/PPP3R1/CALML4/NFATC2/CD247/TNF/GNAI3/ATM/PIK3R2/AKT1/HRAS/PIK3R3/CDK1/NFATC3/ITPR1/GNG7/TAB2/MAPK10/BCL2L1/CGAS/MAP2K6/RPS6KB2/MAPK13/HLA-F/IRAK1/RIPK1/KRAS/CCNB2/AKT2	3.90491022007213
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	53/1861	166/9376	1.60856645280747	MEF2C/PRKG1/CALM2/ATP1B3/GNAI2/ATP1B1/ATP2B1/SLC25A6/PDE3A/GUCY1A2/GTF2I/SLC25A5/SLC8A1/CALM3/GUCY1A1/PLCB1/CALM1/MEF2A/PDE3B/ADRB1/PIK3R5/PPP1CA/MAP2K2/ITPR2/CREB1/GATA4/VDAC3/PIK3CG/PPP3R1/CALML4/NFATC2/PLCB2/GNA13/RGS2/VDAC2/GUCY1B1/AGTR1/GNAI3/VDAC1/PPP1CC/IRS1/AKT1/ADRB2/NFATC3/ITPR1/MEF2D/SLC25A4/CREB3L1/ADCY4/PDE5A/TRPC6/PLCB4/AKT2	3.93664787193861
Organismal Systems	Endocrine system	hsa04924	Renin secretion	27/1861	69/9376	1.97145059925706	CALM2/GNAI2/PDE3A/GUCY1A2/CALM3/GUCY1A1/PLCB1/CALM1/PDE3B/ADRB1/CTSB/ITPR2/CREB1/PTGER4/PPP3R1/CALML4/PLCB2/GUCY1B1/AGTR1/PRKACB/PRKACA/PDE1C/GNAI3/ADRB2/AQP1/ITPR1/PLCB4	4.03027556256297
NA	NA	hsa04517	IgSF CAM signaling	85/1861	299/9376	1.43225043535769	NRP1/SLIT2/MTSS1/TUBA1B/CADM3/PTPRD/CD86/DYNLL1/ARPC3/LCP2/EPB41L2/PMP22/MYL6/MAGI1/PRKCB/CD28/ACTB/UNC5C/ROBO1/NRP2/CD209/ICAM1/DOK2/ROBO2/ARPC5/TUBA1A/INPP5D/LYN/ITGB2/MYL12A/ACTG1/ANK2/MSN/PRKCA/IL1RAPL1/VAV1/EPB41L3/ITGAM/MYL12B/NLGN4X/MAP2K2/CD84/LMO7/TUBB/PIK3CD/ACTR2/MAG/KIRREL1/ICAM2/ARPC4/TUBB2A/ARPC1B/CASK/KDR/NRCAM/NCAM2/ITGA4/SLIT3/CSK/MBP/ANK3/LRFN5/RAPGEF6/JAM3/SPTAN1/PIK3R2/AKT1/DOK1/PIK3R3/ITGAX/NCK2/GIT1/ITGAL/CD48/SLITRK4/MAPK10/GRIP2/MYL6B/ICAM3/EPB41L1/UNC5B/MAPK13/TRPC6/SRGAP3/AKT2	3.78002087404076
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	28/1861	73/9376	1.93244168329003	HGF/CDK6/CCND1/PRKCB/RARB/RB1/PRKCA/EML4/MAP2K2/PIK3CD/BAX/KIF5B/JAK3/CDK4/CDKN2A/PIK3R2/AKT1/TP53/HRAS/PIK3R3/RASSF5/TGFA/STAT5A/POLK/DDB2/RASSF1/KRAS/AKT2	3.97984292282359
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	36/1861	103/9376	1.76090733137524	CD14/COL3A1/LAMA2/COL1A1/COL1A2/CXCL8/PRKCB/TLR4/ITGB2/PLCB1/PRKCA/LAMA4/NFKB1/RAB5C/SERPINB9/ITGAM/GNA14/TLR2/PIK3CD/GNA15/IL1B/PLCB2/SERPINB6/LAMB2/HSPB1/LAMC3/TNF/PRKACB/PRKACA/CXCL1/PIK3R2/ARG2/PIK3R3/TGFB3/C9/PLCB4	3.86397745092713
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	39/1861	116/9376	1.69386129074098	CYBA/CYBB/MMP2/VCAM1/GNAI2/NCF4/PRKCB/PECAM1/ACTB/ICAM1/CD99/ITGB2/MYL12A/ACTG1/MSN/PRKCA/VAV1/ITGAM/ARHGAP5/MYL12B/CLDN5/NCF1/TXK/PIK3CD/THY1/RAC2/NCF2/CDH5/ITGA4/SIPA1/GNAI3/CXCL12/JAM3/PIK3R2/PIK3R3/RASSF5/ITGAL/CLDN11/MAPK13	3.74188549216233
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	37/1861	109/9376	1.71019822626683	CD14/SPP1/CCL3/CCL4/CCL4L2/CCL3L1/LY96/JUN/CXCL8/CD86/TLR4/MAP3K8/TLR1/NFKB1/TLR2/MAP2K2/PIK3CD/TLR7/IL1B/CCL5/TNF/TLR8/PIK3R2/AKT1/PIK3R3/TLR5/TAB2/MAPK10/IRF9/MAP2K6/IRF5/MAPK13/CTSK/TLR6/IRAK1/RIPK1/AKT2	3.71122754657421
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	34/1861	98/9376	1.74793012315082	FCGR3A/MARCKS/PTPRC/FCGR2A/FCGR1A/ARPC3/PRKCB/SYK/BIN1/PLD1/HCK/ARPC5/INPP5D/LYN/CFL1/WAS/PRKCA/WASF2/VAV1/NCF1/PLPP3/PIK3CD/ACTR2/RAC2/ARPC4/ARPC1B/MARCKSL1/FCGR2B/PIK3R2/AKT1/PIK3R3/PLA2G4C/RPS6KB2/AKT2	3.70374613255261
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	26/1861	70/9376	1.87131342596146	LAMA2/HLA-C/CD86/HLA-A/CCND1/HLA-DRA/CD28/ACTB/ICAM1/ITGB2/DTNA/ACTG1/HLA-DPA1/BID/HLA-DQA2/EIF4G3/HLA-DMA/HLA-DMB/RAC2/CYCS/SGCE/PRF1/ITGAL/SGCA/SGCB/HLA-F	3.64113041395086
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	16/1861	36/9376	2.23917845841543	SSBP1/PCNA/RNASEH2C/RPA3/POLD4/POLE4/MCM5/RNASEH2B/RPA2/POLE3/POLD2/MCM3/RFC4/POLE/RNASEH1/RFC2	3.70685842719691
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	40/1861	125/9376	1.61220849005911	FCER1G/GNAI2/PRKCB/ASAH1/PLD1/SGMS1/PLCB1/PRKCA/NFKB1/BID/TNFRSF1A/MAP2K2/PIK3CD/BAX/RAC2/SPTSSA/PLCB2/GNA13/MAP3K5/TNF/GNAI3/S1PR1/PIK3R2/AKT1/TP53/PPP2CB/HRAS/PIK3R3/CERS2/PPP2R5C/MAPK10/PPP2R3C/S1PR2/MAPK13/ORMDL2/ORMDL1/PPP2R5B/PLCB4/KRAS/AKT2	3.42889626395726
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	21/1861	54/9376	1.9592811511135	LDHB/BCAT1/MDH1/MDH2/CISD1/APIP/SRM/GCLM/MAT2A/SDSL/LACC1/SMS/AHCY/PHGDH/SDS/DNMT3A/MAT2B/GOT1/TST/KYAT3/GSS	3.5178925802565
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	41/1861	130/9376	1.58895548299095	COL3A1/COL1A1/GNG2/COL1A2/MMP2/JUN/GNG11/GNAI2/GNG5/GNG10/ARRB2/MMP1/PLCB1/PRKCA/NFKB1/GNGT1/GNB4/GNB2/MAP2K2/ARRB1/PIK3CD/CREB1/GNA15/PLCB2/VEGFB/PRKACB/PRKACA/GNAI3/PIK3R2/AKT1/HRAS/PIK3R3/GNG7/CREB3L1/MAPK10/VEGFC/ADCY4/MAPK13/PLCB4/KRAS/AKT2	3.36489512688827
Human Diseases	Cancer: specific types	hsa05214	Glioma	27/1861	76/9376	1.7898696230097	CALM2/CDK6/IGF1/CCND1/PRKCB/CALM3/RB1/CALM1/PRKCA/MAP2K2/PIK3CD/BAX/CALML4/CAMK2D/CDK4/CDKN2A/PIK3R2/AKT1/TP53/HRAS/PIK3R3/TGFA/PDGFRB/POLK/DDB2/KRAS/AKT2	3.44044853825751
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	34/1861	103/9376	1.66307914629884	C1QA/CCL3/CCL2/C1QC/C1QB/CCL3L1/JUN/CXCL8/GNAI2/TLR4/PLCB1/NFKB1/TNFRSF1A/GNA14/TLR2/PIK3CD/GNA15/IL1B/PLCB2/CCL5/CD247/TNF/GNAI3/PIK3R2/AKT1/PPP2CB/PIK3R3/TGFB3/MAPK10/MAPK13/TLR6/IRAK1/PLCB4/AKT2	3.36719435315207
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	14/1861	31/9376	2.27529424000277	SRP14/SEC61B/SEC61G/SRP9/SPCS1/SEC11A/SPCS2/TMEM208/SPCS3/SEC11C/BAG6/SRP19/GET3/OXA1L	3.53912518386238
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	19/1861	48/9376	1.99426831452624	HMGCLL1/BCAT1/ECHS1/IVD/HADHB/HSD17B10/ACAA1/ALDH9A1/HIBCH/ACAA2/HADHA/ALDH3A2/ACAT1/DLD/ALDH7A1/MCCC1/ACADM/HADH/ABAT	3.43656277720134
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	56/1861	193/9376	1.46184707647847	CXCL14/CCL3/CCL2/CCL4/CCL4L2/GNG2/CCL3L1/CXCL8/GNG11/GNAI2/GNG5/PRKCB/DOCK2/GNG10/CCL8/ARRB2/HCK/LYN/PLCB1/WAS/ELMO1/NFKB1/GNGT1/VAV1/GNB4/GNB2/CX3CR1/CCR1/PIK3R5/NCF1/ARRB1/PREX1/PIK3CD/RAC2/CXCL16/PIK3CG/CCL13/GRK2/PLCB2/CCL5/PRKACB/PRKACA/GNAI3/CXCL12/CXCL1/JAK3/PIK3R2/AKT1/HRAS/PIK3R3/GNG7/ADCY4/NFKBIB/PLCB4/KRAS/AKT2	3.22610793603005
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	36/1861	112/9376	1.61940584938973	LAMA2/LY96/GNAI2/HSPA1A/HLA-DRA/TLR4/HLA-DPA1/LAMA4/NFKB1/TNFRSF1A/HLA-DQA2/PIK3R5/TLR2/HSPA8/HLA-DMA/IL10RA/HLA-DMB/CYCS/PIK3CG/LAMB2/LAMC3/TNF/ALOX5/GNAI3/AKT1/HSPA6/IL10RB/TGFB3/TAB2/MAPK10/BCL2L1/MAP2K6/MAPK13/IRAK1/NFKBIB/AKT2	3.28155262126744
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	70/1861	253/9376	1.39395496917166	CD14/RPS27A/UBA52/UBB/JUN/CXCL8/ARPC3/PYCARD/PFN1/CYTH4/ACTB/NLRP3/ARPC5/TLR4/SEPTIN7/PLCB1/MYL12A/ACTG1/CASP1/WASF2/ELMO1/NFKB1/RBX1/TNFRSF1A/MYL12B/PIK3CD/BAX/ITPR2/ACTR2/TIFA/CYCS/ARPC4/ARPC1B/IL1B/PLCB2/CCL5/TNF/RRAGA/CAPNS1/ATM/VDAC1/TLN1/PIK3R2/AKT1/TP53/PIK3R3/CASP4/TLR5/ITPR1/BCL10/RIPK2/UBE2N/TAB2/MAPK10/BCL2L1/CGAS/PPID/RPS6KB2/MAPK13/MALT1/CAPN1/NAIP/RRAGD/NFKBIB/RIPK1/NLRC4/PLCB4/RRAGB/UBE2D4/AKT2	3.16105708168263
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	41/1861	133/9376	1.55311438187085	GNG2/CALM2/GNG11/GNAI2/GNG5/PRKCB/GNG10/ARRB2/CALM3/PLCB1/CALM1/PRKCA/GNGT1/GNB4/KCNJ5/GNB2/PPP1CA/ARRB1/ITPR2/CREB1/CALML4/CAMK2D/PLCB2/KIF5B/PRKACB/PRKACA/GRIA4/GNAI3/PPP1CC/AKT1/PPP2CB/PPP2R5C/ITPR1/GNG7/CREB3L1/MAPK10/PPP2R3C/MAPK13/PPP2R5B/PLCB4/AKT2	3.19689687611675
Organismal Systems	Nervous system	hsa04730	Long-term depression	22/1861	60/9376	1.84732222819273	PRKG1/IGF1/GNAI2/PRKCB/GUCY1A2/GUCY1A1/LYN/PLCB1/PRKCA/MAP2K2/ITPR2/PLCB2/GNA13/RYR1/GUCY1B1/GNAI3/PPP2CB/HRAS/PLA2G4C/ITPR1/PLCB4/KRAS	3.27645205461712
NA	NA	hsa04518	Integrin signaling	46/1861	154/9376	1.50490240549349	SPP1/LAMA2/HGF/COL1A1/CCND2/COL1A2/COL6A1/COL6A2/PDGFC/IGF1/VCAM1/CCND1/FREM1/ACTB/ICAM1/ITGB2/ACTG1/LAMA4/ITGB5/FERMT3/ITGAM/TNXB/PIK3CD/ICAM2/RAC2/KDR/LAMB2/VTN/VEGFB/ITGA4/LAMC3/PARVB/TLN1/PIK3R2/AKT1/PARVG/COL6A6/PIK3R3/ITGAX/NCK2/ITGAL/ITGA9/VEGFC/PDGFRB/ICAM3/AKT2	3.14376137339355
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	58/1861	204/9376	1.43241563148634	LUM/DCN/HGF/WNT2/COL1A1/COL1A2/MMP2/GPC3/IGF1/RPS6/CCND1/PRKCB/ACTB/HIF1A/TLR4/TWIST1/ACTG1/ANK2/MSN/PLAUR/PRKCA/PLAU/ITGB5/CD63/VAV1/DDX5/PPP1CA/TLR2/MAP2K2/PIK3CD/ITPR2/CAMK2D/KDR/VTN/TNF/SDC2/PRKACB/PRKACA/FZD2/ANK3/HBEGF/PPP1CC/PIK3R2/AKT1/TP53/HRAS/PIK3R3/ITPR1/TWIST2/NUDT16L1/FGF2/RPS6KB2/MAPK13/FZD7/FZD1/SMO/KRAS/AKT2	3.10726846827358
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	26/1861	75/9376	1.74655919756403	CCND2/CDK6/IGF1/CCND1/PMAIP1/BID/BAX/CYCS/ZMAT3/TNFRSF10B/SIVA1/EI24/SESN3/ATM/CDK4/CDKN2A/TP53/CDK1/CD82/BCL2L1/CCNG1/DDB2/RCHY1/GTSE1/CCNB2/RRM2B	3.23016265741547
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	24/1861	68/9376	1.77817112874166	CD14/DUSP6/RUNX1/RUNX1T1/FCGR1A/SPI1/CCND1/NFKB1/BCL2A1/ITGAM/MAP2K2/PIK3CD/EIF4EBP1/CSF1R/LEF1/PIK3R2/AKT1/HRAS/PIK3R3/STAT5A/RPS6KB2/TCF7/KRAS/AKT2	3.20476150393411
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	80/1861	300/9376	1.34350707504926	CD14/MEF2C/HGF/AREG/JUN/DUSP6/PDGFC/IGF1/HSPA1A/PRKCB/STMN1/MKNK1/ARRB2/FGF7/KITLG/MAP3K8/PRKCA/NFKB1/TNFRSF1A/HSPA8/ANGPT1/MAP2K2/ARRB1/CACNB4/CSF1R/DUSP3/RAC2/MAP3K1/EFNA5/PPP3R1/IL1B/BDNF/KDR/CSF1/HSPB1/MAP3K5/VEGFB/MAP3K20/LAMTOR3/TNF/PRKACB/PRKACA/TEK/MAP3K3/MAPKAPK3/RASA2/AKT1/HSPA6/RPS6KA3/MAP2K5/TP53/HRAS/RASGRP3/CACNA2D4/TGFB3/FGF10/NFATC3/MAP3K13/PLA2G4C/TGFA/TAB2/MAX/MAPK10/DAXX/VEGFC/FGF2/CACNA2D1/PDGFRB/DUSP9/PPM1A/RELB/MAP2K6/MAPK13/CDC25B/IRAK1/DUSP7/DDIT3/FGFR3/KRAS/AKT2	3.0091469895885
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	94/1861	362/9376	1.30824929269299	SPP1/LAMA2/HGF/COL1A1/GNG2/CCND2/COL1A2/COL6A1/COL6A2/AREG/CDK6/PDGFC/IGF1/LPAR6/GNG11/RPS6/CCND1/GNG5/MAGI1/GNG10/SYK/YWHAB/TLR4/FGF7/KITLG/YWHAH/PRKCA/LAMA4/ITGB5/NFKB1/GNGT1/PIK3AP1/GNB4/TNXB/GNB2/HSP90AB1/PIK3R5/TLR2/ANGPT1/MAP2K2/PIK3CD/EIF4EBP1/CSF1R/CREB1/EFNA5/PIK3CG/BDNF/KDR/CSF1/LPAR5/LAMB2/EIF4E/VTN/VEGFB/SGK3/ITGA4/LAMC3/IL2RA/TEK/JAK3/CDK4/PKN1/PIK3R2/IRS1/AKT1/TP53/PPP2CB/COL6A6/HRAS/PIK3R3/PPP2R5C/FGF10/EIF4E2/IL6R/PCK2/CDKN1B/TGFA/GNG7/CREB3L1/ITGA9/VEGFC/FGF2/BCL2L1/OSM/PDGFRB/PPP2R3C/RPS6KB2/G6PC3/PPP2R5B/FGFR3/CSHL1/KRAS/MLST8/AKT2	2.97640434216706
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	27/1861	80/9376	1.70037614185922	HGF/PDGFC/IGF1/RPS6/PRKCB/GAS6/PRKCA/MAP2K2/PIK3CD/BAX/EIF4EBP1/KDR/EIF4E/PIK3R2/AKT1/HRAS/PIK3R3/EIF4E2/IL6R/TGFA/FGF2/BCL2L1/PDGFRB/RPS6KB2/FGFR3/KRAS/AKT2	3.13056418057481
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	24/1861	69/9376	1.75240053267294	FCER1G/LCP2/SYK/INPP5D/LYN/PRKCA/VAV1/ALOX5AP/MAP2K2/PIK3CD/RAC2/TNF/ALOX5/PIK3R2/AKT1/HRAS/PIK3R3/PLA2G4C/BTK/MAPK10/MAP2K6/MAPK13/KRAS/AKT2	3.12149838850293
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	18/1861	47/9376	1.92950484182606	LDHB/AKR1A1/ME1/ME2/MDH1/MDH2/ACSS1/HAGH/ALDH9A1/GRHPR/FH/ADH5/PDHB/PCK2/ALDH3A2/ACAT1/DLD/ALDH7A1	3.1789036946829
Human Diseases	Cancer: specific types	hsa05218	Melanoma	25/1861	73/9376	1.72539436008038	HGF/CDK6/PDGFC/IGF1/CCND1/FGF7/RB1/MAP2K2/PIK3CD/BAX/CDK4/CDKN2A/PIK3R2/AKT1/MITF/TP53/HRAS/PIK3R3/FGF10/FGF2/PDGFRB/POLK/DDB2/KRAS/AKT2	3.09612457482136
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	29/1861	89/9376	1.64164488102929	PRKG1/TUBA1B/PDGFC/GNAI2/PRKCB/GUCY1A2/TUBA1A/GUCY1A1/GJA1/PLCB1/PRKCA/ADRB1/MAP2K2/TUBB/ITPR2/TUBB2A/PLCB2/GUCY1B1/PRKACB/PRKACA/GNAI3/MAP2K5/HRAS/CDK1/ITPR1/PDGFRB/ADCY4/PLCB4/KRAS	3.02653950252305
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	15/1861	37/9376	2.04249386409515	HBB/HBA2/HBA1/VCAM1/PRKCB/ICAM1/PLCB1/PRKCA/LAMA4/IDO2/IL1B/PLCB2/TNF/IDO1/PLCB4	3.16168438345925
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	30/1861	93/9376	1.62521017143055	CALM2/MMP2/JUN/EGR1/PRKCB/PLD1/CALM3/PLCB1/CALM1/PRKCA/MAP2K2/ITPR2/MAP3K1/CALML4/CAMK2D/CGA/PLCB2/PRKACB/PRKACA/MAP3K3/HBEGF/HRAS/PLA2G4C/ITPR1/MAPK10/MAP2K6/ADCY4/MAPK13/PLCB4/KRAS	3.0152107041852
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	22/1861	63/9376	1.75935450304069	POLR2L/GTF2H5/POLR2K/RBX1/POLR2J/POLR2I/PCNA/RPA3/POLR2E/POLR2G/RAD23A/POLD4/POLE4/XPA/RPA2/POLE3/POLD2/RFC4/DDB2/GTF2H3/POLE/RFC2	3.00929233023196
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	46/1861	160/9376	1.44846856528748	PTPRC/HLA-C/CADM3/PTPRD/VCAN/VCAM1/CD86/HLA-A/HLA-DRA/PECAM1/CD28/CD4/ICAM1/SIGLEC1/CD99/ITGB2/HLA-DPA1/ALCAM/ITGAM/HLA-DQA2/CLDN5/NLGN4X/HLA-DMA/HLA-DMB/MAG/ICAM2/CD34/CDH5/NRCAM/NCAM2/ITGA4/PTPRM/SDC2/JAM3/CD58/LRRC4/SDC3/ITGAL/SLITRK4/ITGA9/NTNG1/ICAM3/SELL/SELPLG/CLDN11/HLA-F	2.84718113763959
Human Diseases	Infectious disease: viral	hsa05162	Measles	40/1861	136/9376	1.48180927395139	CCND2/CDK6/JUN/RACK1/HSPA1A/CCND1/CD28/CD209/TLR4/MSN/NFKB1/BID/TLR2/HSPA8/PIK3CD/BAX/TLR7/CYCS/IL1B/IL2RA/EIF2S1/JAK3/RAB9A/CDK4/FCGR2B/PIK3R2/AKT1/HSPA6/TP53/PIK3R3/CDKN1B/STAT5A/TAB2/MAPK10/IRF9/BCL2L1/IRAK1/NFKBIB/RCHY1/AKT2	2.81645590355326
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	16/1861	42/9376	1.91929582149894	IDO2/ECHS1/CAT/KYNU/HAAO/ALDH9A1/IDO1/INMT/HADHA/AFMID/ALDH3A2/ACAT1/DLD/ALDH7A1/KYAT3/HADH	2.97125800875164
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	35/1861	116/9376	1.52013192758806	PGLS/ME1/ESD/ME2/MDH1/TKT/ECHS1/CAT/MDH2/TALDO1/ACSS1/FH/HIBCH/ADH5/SUCLG1/SDSL/GLUD1/PDHB/PGP/SDHD/PHGDH/PGAM1/IDH3G/SDHC/PRPS2/IDH3B/GPI/SDS/PRPS1/SHMT2/GOT1/ACAT1/DLD/ACO2/PFKM	2.80499019014844
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	52/1861	187/9376	1.40098331355404	CCL2/CYBA/CYBB/JUN/CXCL8/IFI16/GABARAP/PYCARD/NAMPT/NLRP3/TLR4/PLCB1/CARD16/GPSM3/CASP1/GABARAPL2/NFKB1/TANK/TRPM2/ANTXR1/CTSB/HSP90AB1/ITPR2/VDAC3/IL1B/PLCB2/TXN2/VDAC2/CCL5/NLRP1/TNF/CXCL1/VDAC1/TRIP6/PKN1/PSTPIP1/CASP4/ITPR1/RIPK2/TAB2/MAPK10/SUGT1/IRF9/CARD8/BCL2L1/MAPK13/NAIP/NFKBIB/RIPK1/NLRC4/PLCB4/GBP2	2.75617830669326
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	22/1861	65/9376	1.70522051833175	SPP1/PRKCB/KISS1/ARRB2/PLCB1/PRKCA/KCNJ5/MAP2K2/ARRB1/PIK3CD/ITPR2/CGA/PLCB2/PIK3R2/AKT1/TRPC1/HRAS/PIK3R3/ITPR1/PLCB4/KRAS/AKT2	2.83908102349204
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	48/1861	173/9376	1.39786863299923	CCL2/CDK6/CXCL8/PYCARD/SLC25A6/PRKCB/HLA-DRA/ACTB/SLC25A5/ICAM1/NLRP3/TLR4/ACTG1/HLA-DPA1/PRKCA/CASP1/NFKB1/RAB11A/BID/TNFRSF1A/HLA-DQA2/SOCS3/MAP2K2/HLA-DMA/PIK3CD/BAX/HLA-DMB/TLR7/CYCS/IL1B/IL33/TNFRSF10B/CCL5/TNF/EIF2S1/VDAC1/CDK4/KPNA2/PIK3R2/AKT1/FDPS/PIK3R3/SLC25A4/IRF9/KPNA5/NFKBIB/RSAD2/AKT2	2.62840554438319
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	28/1861	90/9376	1.5674249208908	IGF1/NFKB1/PIK3CD/BAX/EIF4EBP1/CREB1/CAT/EIF4E/KL/SESN3/ADIPOR1/PRKACB/PRKACA/APPL1/PIK3R2/IRS1/AKT1/TP53/HRAS/PIK3R3/EIF4E2/CREB3L1/PRKAG1/RPS6KB2/ADCY4/SIRT1/KRAS/AKT2	2.69159462978306
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	53/1861	195/9376	1.36934374956943	CYBA/FCGR3A/CYBB/CR1/HDAC9/FCGR2A/FCGR1A/NCF4/HMGB1/SLC25A6/CLEC7A/PRKCB/SYK/ACTB/SLC25A5/TLR4/ITGB2/PLCB1/ACTG1/PRKCA/CASP1/CLCN5/NFKB1/FPR1/ITGAM/TLR2/NCF1/MAP2K2/PIK3CD/ATG7/RAC2/TLR7/VDAC3/NCF2/PLCB2/VDAC2/HDAC8/TLR8/VDAC1/PIK3R2/AKT1/HDAC2/PIK3R3/CASP4/ITGAL/SLC25A4/SIGLEC9/SELPLG/MAPK13/CLCN3/CR1L/PLCB4/AKT2	2.59356656072915
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	16/1861	44/9376	1.8320551023399	HLA-C/CD86/HLA-A/HLA-DRA/CD28/HLA-DPA1/ICA1/HLA-DQA2/HLA-DMA/HLA-DMB/IL1B/GZMB/TNF/PRF1/HLA-F/PTPRN2	2.7528680389195
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	22/1861	67/9376	1.65431841330692	CALM2/PRKCB/CALM3/PLCB1/CALM1/PRKCA/PPP1CA/MAP2K2/ITPR2/PPP3R1/CALML4/CAMK2D/PLCB2/GRIN2C/PRKACB/PRKACA/PPP1CC/RPS6KA3/HRAS/ITPR1/PLCB4/KRAS	2.67466478981243
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	27/1861	87/9376	1.56356426837629	AREG/JUN/CCND1/PMAIP1/MAP2K2/PIK3CD/BAX/RAC2/CYCS/LEF1/APPL1/PIK3R2/AKT1/TP53/HRAS/PIK3R3/TGFB3/TGFA/MAPK10/POLK/DDB2/RPS6KB2/BIRC5/TCF7/KRAS/AKT2/MSH6	2.62792476086979
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	12/1861	30/9376	2.01526061257389	MDH1/MDH2/FH/SUCLG1/PDHB/SDHD/PCK2/IDH3G/SDHC/IDH3B/DLD/ACO2	2.7715301614642
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	15/1861	41/9376	1.84322617003709	MMP2/CXCL8/CCND1/MMP1/RB1/TYMP/MAP2K2/HBEGF/CDK4/CDKN2A/TP53/HRAS/RASSF1/FGFR3/KRAS	2.69260827529602
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	43/1861	154/9376	1.40675659643956	RYR2/CALM2/ATP1B3/GNAI2/ATP1B1/ATP2B1/CREM/SLC8A1/CALM3/PLCB1/TPM3/CALM1/PRKCA/SCN1B/ADRB1/KCNQ1/PIK3R5/PPP1CA/CACNB4/CREB1/PIK3CG/CALML4/CAMK2D/PLCB2/AGTR1/PRKACB/PRKACA/GNAI3/PPP1CC/AKT1/PPP2CB/CACNA2D4/PPP2R5C/ADRB2/CREB3L1/MYL4/CACNA2D1/PPP2R3C/ADCY4/MAPK13/PPP2R5B/PLCB4/AKT2	2.53265910866456
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	62/1861	238/9376	1.31245964264266	HGF/GNG2/CALM2/PDGFC/IGF1/GNG11/GNG5/RGL1/PRKCB/GNG10/PLD1/CALM3/FGF7/KITLG/CALM1/PRKCA/NFKB1/GNGT1/RAB5C/GNB4/GNB2/ANGPT1/MAP2K2/PIK3CD/CSF1R/RAC2/EFNA5/REL/CALML4/RASA3/BDNF/KDR/CSF1/VEGFB/RAPGEF5/PRKACB/PRKACA/TEK/ETS1/RASA2/PIK3R2/AKT1/PLAAT3/HRAS/RASGRP3/PIK3R3/RASSF5/FGF10/PLA2G4C/TGFA/RASA4/GNG7/MAPK10/VEGFC/FGF2/BCL2L1/PDGFRB/RASAL3/RASSF1/FGFR3/KRAS/AKT2	2.42969167535469
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	24/1861	77/9376	1.57033294486277	CDK6/RUNX1/CCND1/RB1/NFKB1/MAP2K2/PIK3CD/BAX/CDK4/CDKN2A/PIK3R2/AKT1/HDAC2/TP53/HRAS/PIK3R3/TGFB3/CDKN1B/STAT5A/BCL2L1/POLK/DDB2/KRAS/AKT2	2.50063341416217
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	32/1861	110/9376	1.46564408187192	CYBB/IGF1/RPS6/ELOB/PRKCB/LDHB/MKNK1/HIF1A/TLR4/PRKCA/NFKB1/RBX1/ELOC/ANGPT1/MAP2K2/PIK3CD/EIF4EBP1/CAMK2D/EIF4E/TEK/PDHB/PIK3R2/AKT1/LTBR/PIK3R3/EIF4E2/IL6R/CDKN1B/EGLN2/RPS6KB2/PFKM/AKT2	2.44454825498365
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	27/1861	90/9376	1.51144545943041	JUN/CD28/CD4/HIF1A/TLR4/NFKB1/EML4/TLR2/MAP2K2/PIK3CD/PPP3R1/NFATC2/CD247/MAP3K3/PIK3R2/AKT1/HRAS/PIK3R3/NFKBIE/NFATC3/MAP2K6/RPS6KB2/MAPK13/BATF/NFKBIB/KRAS/AKT2	2.42605462211406
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	33/1861	115/9376	1.44573043945518	GNG2/GNG11/GNAI2/GNG5/PRKCB/GNG10/PLCB1/PRKCA/GNGT1/GNB4/GNB2/KCNQ1/PIK3R5/PIK3CD/ITPR2/CREB1/PIK3CG/CAMK2D/PLCB2/PRKACB/PRKACA/GNAI3/PIK3R2/AKT1/HRAS/PIK3R3/ITPR1/GNG7/CREB3L1/ADCY4/PLCB4/KRAS/AKT2	2.39324193446381
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	20/1861	62/9376	1.62521017143055	IGF1/HSPA1A/HSPA8/PIK3CD/CAT/PRKACB/PRKACA/PIK3R2/IRS1/AKT1/HSPA6/HDAC2/HRAS/PIK3R3/PRKAG1/RPS6KB2/ADCY4/SIRT1/KRAS/AKT2	2.45780880150949
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	53/1861	201/9376	1.32846781674647	CD14/MEF2C/MAF/CCND2/DUSP6/CXCL8/NR4A3/IGF1/CD86/RUNX1/RUNX1T1/FCGR1A/SPI1/FLI1/BMP2K/LMO2/PROM1/PLAU/ETV5/NFKB1/BCL2A1/TSPAN7/DDX5/ITGAM/NFKBIZ/ID2/LYL1/BAX/CSF1R/KLF3/NUPR1/PBX3/REL/HHEX/GZMB/CDK14/ETV1/ATM/MITF/HDAC2/TP53/CDKN1B/MLLT1/MAX/HOXA10/MEIS1/BCL2L1/POLK/DDB2/CDKN2C/DDIT3/ERG/TFE3	2.34251374793235
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	43/1861	158/9376	1.37114250539046	WNT2/IGF1/RPS6/PRKCB/ATP6V1F/LAMTOR4/ATP6V1G1/LAMTOR5/LAMTOR2/PRKCA/TNFRSF1A/LAMTOR1/PRR5/MAP2K2/PIK3CD/EIF4EBP1/LRP6/ATP6V1D/EIF4E/ATP6V1B2/LAMTOR3/TNF/RRAGA/FZD2/CASTOR1/PIK3R2/IRS1/AKT1/RPS6KA3/HRAS/PIK3R3/EIF4E2/STRADB/MIOS/RPS6KB2/ATP6V1A/RRAGD/FZD7/FZD1/RRAGB/KRAS/MLST8/AKT2	2.34123613792568
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	29/1861	99/9376	1.4758221657738	MMP2/JUN/IGF1/CCND1/RB1/MAP2K2/PIK3CD/BAX/PRKACB/PRKACA/HBEGF/CDK4/CDKN2A/PIK3R2/AKT1/TP53/HRAS/NOTCH3/PIK3R3/CDKN1B/DLL4/MAPK10/NOTCH1/RPS6KB2/ADCY4/MAPK13/CDKN2C/KRAS/AKT2	2.36838782962764
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	48/1861	180/9376	1.34350707504926	CCL2/HLA-C/CD74/HLA-A/HLA-DRA/SYK/POU2F2/HLA-DPA1/NFKB1/SRSF3/BID/TNFRSF1A/HLA-DQA2/SOCS3/PPP1CA/TLR2/HLA-DMA/PIK3CD/BAX/EIF4EBP1/HLA-DMB/CYCS/SRSF9/IL1B/CCL5/TNF/EIF2S1/TNFRSF14/PPP1CC/PIK3R2/AKT1/TP53/ALYREF/PIK3R3/TAB2/SRSF8/SRSF6/DAXX/IRF9/BCL2L1/HCFC1/CGAS/PILRA/HLA-F/EIF2B3/IRAK1/EIF2B2/AKT2	2.31561732384869
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	34/1861	120/9376	1.42747626723984	CALM2/JUN/CALM3/SH2B3/CALM1/NFKB1/MAP2K2/PIK3CD/BAX/MAP3K1/ARHGDIB/CALML4/CAMK2D/BDNF/MAP3K5/BEX3/IRAK2/MAP3K3/PIK3R2/IRS1/AKT1/RPS6KA3/MAP2K5/TP53/HRAS/PIK3R3/NFKBIE/RIPK2/MAPK10/MAPK13/IRAK1/NFKBIB/KRAS/AKT2	2.34522918881859
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	17/1861	51/9376	1.67938384381157	SEC61B/ATP6V1F/ACTB/ATP6V1G1/SEC61G/ACTG1/ATP6V0B/PRKCA/ATP6V0C/KCNQ1/ATP6V1D/ATP6V1B2/ATP6V0D1/PRKACB/PRKACA/ATP6V0A1/ATP6V1A	2.42086301201604
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	19/1861	59/9376	1.62245557791965	PRKG1/GNAI2/PDE3B/ADRB1/PIK3CD/CGA/PRKACB/PRKACA/GNAI3/PIK3R2/IRS1/AKT1/PLAAT3/PIK3R3/ADRB2/ABHD5/PTGS1/ADCY4/AKT2	2.38666054394105
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	30/1861	105/9376	1.4394718661242	RPS27A/UBA52/UBB/JUN/TOMM7/GABARAP/HIF1A/GABARAPL2/RAB5C/TOMM20/FIS1/USP15/VCP/PRKN/SMURF2/EIF2S1/MITF/TP53/HRAS/PHB2/MTX1/FUNDC1/MAPK10/BCL2L1/RHOT1/SAMM50/TFEB/MTX2/KRAS/TFE3	2.25349588398257
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	23/1861	76/9376	1.52470375293419	CALM2/ATP1B3/GNAI2/ATP1B1/PRKCB/ACTB/CALM3/PLCB1/ACTG1/CALM1/PRKCA/KCNQ1/HRH2/ITPR2/CALML4/CAMK2D/PLCB2/PRKACB/PRKACA/GNAI3/ITPR1/ADCY4/PLCB4	2.28546105232166
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	34/1861	122/9376	1.40407501695721	PTPRC/JUN/LCP2/CD28/CD4/MAP3K8/NFKB1/VAV1/MAP2K2/PIK3CD/PPP3R1/TEC1/NFATC2/CD247/TNF/CDK4/PIK3R2/AKT1/PPP2CB/HRAS/PIK3R3/NFKBIE/PPP2R5C/NFATC3/BCL10/NCK2/MAPK10/PPP2R3C/MAPK13/MALT1/PPP2R5B/NFKBIB/KRAS/AKT2	2.23548366049379
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	34/1861	122/9376	1.40407501695721	SLC16A10/ATP1B3/ATP1B1/CCND1/PRKCB/BMP4/ACTB/HIF1A/PLCB1/ACTG1/PRKCA/MAP2K2/PIK3CD/GATA4/PLCB2/PRKACB/PRKACA/MED30/PIK3R2/AKT1/THRA/HDAC2/TP53/HRAS/NOTCH3/PIK3R3/PFKFB2/NOTCH1/TBC1D4/MED16/PLCB4/PFKM/KRAS/AKT2	2.23548366049379
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	42/1861	157/9376	1.34778576000164	C1QA/CD36/C1QC/C1QB/STAB1/GAS6/PECAM1/HIF1A/PROS1/ITGB5/CASP1/ELMO1/RAB5C/SIRPA/CX3CR1/MAP2K2/LRP1/CD47/CREB1/PTGER4/HAVCR2/PLA2G15/CAMK2D/NFATC2/ADAM9/UQCRFS1/LIPA/ALOX5/ODC1/S1PR1/ARG2/NFATC3/ATP8A1/CH25H/ATP11B/DNMT3A/CD24/MAPK13/SCARF1/DUSP7/SIRT1/VPS11	2.18682508474493
Organismal Systems	Digestive system	hsa04970	Salivary secretion	27/1861	93/9376	1.4626891542875	CST3/PRKG1/CALM2/ATP1B3/ATP1B1/ATP2B1/PRKCB/LYZ/GUCY1A2/CALM3/GUCY1A1/PLCB1/CALM1/PRKCA/ADRB1/ITPR2/CALML4/PLCB2/VAMP2/GUCY1B1/PRKACB/PRKACA/CD38/ADRB2/ITPR1/ADCY4/PLCB4	2.23141809661526
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	63/1861	250/9376	1.26961418592155	DAB2/FOLR2/WWP1/HLA-C/HLA-A/ARPC3/SNX6/HSPA1A/CLTA/PSD3/CLTC/BIN1/SNX2/CYTH4/PLD1/AP2S1/ARRB2/ARPC5/VPS29/VPS28/EPS15/RAB5C/RAB11A/CHMP2A/AP2M1/CAPZA2/HSPA8/CAPZB/ARRB1/SNX3/ACAP2/ACTR2/ARF5/ARPC4/CHMP5/CHMP4A/ARPC1B/GRK2/EPN1/VPS35/ZFYVE16/KIF5B/MVB12B/IL2RA/SMURF2/CAPZA1/HSPA6/ARF3/SPG21/EHD4/HRAS/EEA1/ARAP1/GIT1/GIT2/RABEP1/ARAP2/VTA1/HLA-F/FGFR3/RNF41/RAB11FIP2/VPS45	2.15014051949701
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	23/1861	77/9376	1.50490240549349	CDK6/CCND1/PLD1/RB1/NFKB1/PIK3CD/BAX/RAC2/CDK4/CDKN2A/PIK3R2/AKT1/TP53/PIK3R3/TGFB3/TGFA/MAPK10/BCL2L1/POLK/DDB2/RPS6KB2/KRAS/AKT2	2.21375222567875
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	33/1861	119/9376	1.39713445829702	CCL2/JUN/VCAM1/JUNB/ICAM1/TNFRSF1B/MAP3K8/NFKB1/TNFRSF1A/SOCS3/PIK3CD/CREB1/IL1B/CSF1/MAP3K5/CCL5/TNF/RHBDF2/CXCL1/CASP10/PIK3R2/AKT1/PIK3R3/IRF1/CYLD/TAB2/CREB3L1/MAPK10/VEGFC/MAP2K6/MAPK13/RIPK1/AKT2	2.16955294222426
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	17/1861	53/9376	1.6160108685734	ATP1B3/ATP1B1/ATP2B1/CLTA/PRKCB/CLTC/AP2S1/SLC8A1/PLCB1/PRKCA/RAB11A/AP2M1/PLCB2/KL/PRKACB/PRKACA/PLCB4	2.23791094183453
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	11/1861	30/9376	1.84732222819273	FOLR2/NFKB1/IL1B/ABCC5/ABCC4/TNF/MTHFR/ABCG2/SLC46A1/TYMS/SHMT2	2.31308009276711
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	9/1861	23/9376	1.97145059925706	SSBP1/PCNA/RPA3/POLD4/RPA2/POLD2/RFC4/RFC2/MSH6	2.32115158639003
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	28/1861	99/9376	1.42493174626436	CALM2/IGF1/PRKCB/HRH1/CALM3/PLCB1/CALM1/PRKCA/PPP1CA/PIK3CD/ITPR2/PTGER4/CALML4/CAMK2D/IL1B/PLCB2/PRKACB/PRKACA/PPP1CC/PIK3R2/PIK3R3/PLA2G4C/ITPR1/MAPK10/MAP2K6/ADCY4/MAPK13/PLCB4	2.11508258476836
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	38/1861	142/9376	1.34823773376422	RPS27A/UBA52/UBB/WWP1/ELOB/ANAPC11/PIAS2/RNF7/RBX1/ELOC/SOCS3/CDC34/MAP3K1/UBE2I/UBE2E3/UBE2W/UBE2M/UBE2B/PRKN/SMURF2/UBE2C/CDC26/ANAPC13/STUB1/UBE2S/ANAPC15/UBE2J1/CDC27/UBE2N/FBXO4/FANCL/DDB2/RHOBTB1/UBA7/ANAPC10/RCHY1/KEAP1/UBE2D4	2.08074757556768
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	16/1861	50/9376	1.61220849005911	LAP3/GATM/SAT2/CNDP2/GAMT/SRM/ALDH9A1/ODC1/SMS/ARG2/SMOX/OAT/ALDH3A2/GOT1/ALDH7A1/PYCR2	2.15988673370883
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	11/1861	31/9376	1.78773118857361	MDH1/CAT/MDH2/ACSS1/GRHPR/PGP/AFMID/SHMT2/ACAT1/DLD/ACO2	2.1860674973241
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	22/1861	75/9376	1.47785778255418	PMAIP1/GSTO1/BID/MGST2/PIK3CD/BAX/CYCS/MAP3K5/TOP2A/ATM/CDKN2A/PIK3R2/AKT1/XPA/TP53/PIK3R3/BCL2L1/BIRC5/GSTA4/ATP7A/AKT2/MSH6	2.06756325526281
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	21/1861	71/9376	1.49015749521308	JUN/CXCL8/ATP6V1F/ATP6V1G1/LYN/ATP6V0B/NFKB1/ATP6V0C/ATP6V1D/ATP6V1B2/CCL5/CSK/ATP6V0D1/CXCL1/HBEGF/JAM3/GIT1/MAPK10/ATP6V0A1/MAPK13/ATP6V1A	2.06300825577335
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	80/1861	333/9376	1.21036673427861	SPP1/LAMA2/WNT2/COL1A1/CCND2/COL1A2/COL6A1/COL6A2/HLA-C/RBPJ/CDK6/HLA-A/CCND1/MAGI1/ATP6V1F/ATP6V1G1/RB1/ATP6V0B/LAMA4/ITGB5/NFKB1/ATP6V0C/TNFRSF1A/TNXB/MAP2K2/PIK3CD/BAX/EIF4EBP1/CREB1/PTGER4/ATP6V1D/LAMB2/ATP6V1B2/VTN/ITGA4/LAMC3/TNF/ATP6V0D1/PRKACB/PRKACA/FZD2/ATM/CDK4/PIK3R2/AKT1/HDAC2/TP53/PPP2CB/COL6A6/HRAS/NOTCH3/PIK3R3/PPP2R5C/IRF1/CDKN1B/CREB3L1/ITGA9/IRF9/NOTCH1/ATP6V0A1/RFNG/PDGFRB/PPP2R3C/TADA3/RPS6KB2/LFNG/ATP6V1A/PPP2R5B/TUBG1/HLA-F/HES4/RBL1/DLG3/FZD7/FZD1/TCF7/TBPL1/MFNG/KRAS/AKT2	1.9450790163291
Human Diseases	Immune disease	hsa05330	Allograft rejection	13/1861	39/9376	1.67938384381157	HLA-C/CD86/HLA-A/HLA-DRA/CD28/HLA-DPA1/HLA-DQA2/HLA-DMA/HLA-DMB/GZMB/TNF/PRF1/HLA-F	2.11562247125797
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	28/1861	101/9376	1.39671527604131	WNT2/CALM2/GNAI2/PRKCB/CALM3/KITLG/PLCB1/CALM1/PRKCA/MAP2K2/CREB1/CALML4/CAMK2D/PLCB2/LEF1/PRKACB/PRKACA/FZD2/GNAI3/MITF/HRAS/CREB3L1/ADCY4/FZD7/FZD1/PLCB4/TCF7/KRAS	1.9946972270191
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	30/1861	110/9376	1.37404132675492	DCN/BMP5/PITX2/BMP4/EMP3/RBX1/BAMBI/ID2/ACVR2A/SMAD5/SMAD6/FMOD/ID1/ZFYVE16/NRROS/SMURF2/TNF/NBL1/HDAC2/GDF6/PPP2CB/TGFB3/TGIF2/E2F4/BMP7/RPS6KB2/FST/RBL1/BMPR1A/LRRC32	1.96365015299824
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	10/1861	28/9376	1.79933983265525	ELOVL2/HACD4/ECHS1/HADHB/HACD3/PPT1/HSD17B12/ACAA2/HADHA/HADH	2.10787790408303
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	10/1861	28/9376	1.79933983265525	ATP6V1F/ATP6V1G1/ATP6V0C/ATP6V1D/ATP6V1B2/SLC12A7/ATP6V0D1/SLC4A1/ATP6V0A1/ATP6V1A	2.10787790408303
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	42/1861	163/9376	1.29817401423471	JUN/CXCL8/PRKCB/YWHAB/TLR4/RB1/PRKCA/NFKB1/EGR2/BID/TLR2/MAP2K2/PCNA/PIK3CD/BAX/CREB1/MAP3K1/CYCS/VDAC3/NFATC2/TNF/JAK3/CASP10/PIK3R2/AKT1/TP53/HRAS/PIK3R3/EGR3/TGFB3/NFATC3/STAT5A/TAB2/CREB3L1/MAPK10/MAP2K6/DDB2/BIRC5/MAPK13/IRAK1/KRAS/AKT2	1.91098549693911
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	18/1861	60/9376	1.51144545943041	PRKCB/PRKCA/MAP2K2/PIK3CD/RAC2/PPP3R1/NFATC2/KDR/HSPB1/MAPKAPK3/PIK3R2/AKT1/HRAS/PIK3R3/PLA2G4C/MAPK13/KRAS/AKT2	1.97767327543097
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	14/1861	44/9376	1.60304821454741	HMGB1/PCNA/PARP1/POLD4/APEX1/POLE4/MPG/POLE3/POLD2/RFC4/NTHL1/MBD4/POLE/RFC2	1.99519497096585
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	8/1861	21/9376	1.91929582149894	ENPP1/DPYD/BCAT1/PPCS/VNN2/PPCDC/AASDHPPT/ALDH3A2	2.09863721476748
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	31/1861	116/9376	1.34640256443514	GNG2/GNG11/GNAI2/GNG5/PRKCB/GNG10/PLD1/SLC1A6/PLCB1/PRKCA/GNGT1/DLGAP1/GNB4/HOMER3/GNB2/ITPR2/PPP3R1/GRK2/PLCB2/GRIN2C/PRKACB/PRKACA/GRIA4/GNAI3/TRPC1/PLA2G4C/ITPR1/GNG7/ADCY4/DLG4/PLCB4	1.86809488813456
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	23/1861	82/9376	1.4131400636951	LGMN/HLA-C/CD74/HLA-A/HSPA1A/HLA-DRA/CD4/CTSS/HLA-DPA1/HLA-DQA2/CTSB/HSP90AB1/HSPA8/HLA-DMA/HLA-DMB/PSME2/CREB1/PSME1/TNF/RFXANK/HSPA6/HLA-F/NFYC	1.86980895999575
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	36/1861	139/9376	1.30484500094712	CALM2/MMP2/JUN/GNAI2/HSPA1A/CALM3/PLCB1/CALM1/KRT10/KCNJ5/HSP90AB1/HSPA8/MAP2K2/PIK3CD/ITPR2/CREB1/CALML4/PLCB2/PRKACB/PRKACA/GNAI3/HBEGF/PIK3R2/AKT1/HSPA6/HRAS/PIK3R3/ITPR1/TGFA/KRT24/CREB3L1/ADCY4/FKBP4/PLCB4/KRAS/AKT2	1.80183632558366
Human Diseases	Substance dependence	hsa05032	Morphine addiction	25/1861	91/9376	1.38410756358097	GNG2/PDE4D/GNG11/GNAI2/PDE4B/GNG5/PRKCB/GNG10/PDE3A/ARRB2/PRKCA/PDE3B/GNGT1/GNB4/KCNJ5/GNB2/ARRB1/GRK2/GABRA3/PRKACB/PRKACA/PDE1C/GNAI3/GNG7/ADCY4	1.83221710602338
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	12/1861	37/9376	1.63399509127612	CCND1/NCOA4/TPM3/MAP2K2/BAX/LEF1/TP53/HRAS/POLK/DDB2/TCF7/KRAS	1.92278578159054
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	14/1861	45/9376	1.5674249208908	HLA-C/CD86/HLA-A/HLA-DRA/CD28/HLA-DPA1/HLA-DQA2/HLA-DMA/HLA-DMB/IL1B/GZMB/TNF/PRF1/HLA-F	1.89864994158496
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	46/1861	184/9376	1.25953788285868	NRP1/SLIT2/EPHA3/GNAI2/UNC5C/ROBO1/ROBO2/MYL12A/CFL1/PRKCA/MYL12B/EFNB2/ENAH/PIK3CD/RAC2/EFNA5/ABLIM3/PPP3R1/CAMK2D/NFATC2/SEMA3B/FES/EPHA7/EPHA5/SLIT3/SEMA3G/GNAI3/CXCL12/SEMA3D/PIK3R2/TRPC1/LRRC4/HRAS/PIK3R3/NFATC3/NCK2/NTNG1/RGS3/BMP7/UNC5B/TRPC6/SMO/SRGAP3/KRAS/PLXNC1/EPHA4	1.76928988062479
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	20/1861	70/9376	1.4394718661242	HGF/JUN/ELOB/HIF1A/RBX1/ELOC/MAP2K2/PIK3CD/FH/ETS1/PIK3R2/AKT1/HRAS/PIK3R3/TGFB3/TGFA/EGLN2/KRAS/AKT2/TFE3	1.83650834492174
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	32/1861	122/9376	1.32148236890091	IGF1/GNAI2/JUNB/PRKCB/PLCB1/PRKCA/SOCS3/MAP2K2/PIK3CD/ITPR2/CREB1/MAP3K1/PLCB2/PRKACB/PRKACA/GNAI3/PIK3R2/IRS1/AKT1/HRAS/PIK3R3/ITPR1/STAT5A/CREB3L1/MAPK10/MAP2K6/ADCY4/MAPK13/CSHL1/PLCB4/KRAS/AKT2	1.77855237927494
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	24/1861	88/9376	1.37404132675492	F13A1/C1QA/C1QC/CFD/CR1/C1QB/A2M/C3AR1/PROS1/VSIG4/C1R/ITGB2/PLAUR/C2/PLAU/CLU/ITGAM/C4BPB/VTN/CFI/C9/ITGAX/F5/CR1L	1.75426077940708
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	13/1861	42/9376	1.55942785496789	CYBB/FTL/SLC40A1/GPX4/NCOA4/PRNP/SAT2/ATG7/VDAC3/VDAC2/GCLM/TP53/GSS	1.80812797743583
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	25/1861	93/9376	1.35434180952546	MAF/RBPJ/JUN/IL12RB2/HLA-DRA/CD4/HLA-DPA1/NFKB1/HLA-DQA2/HLA-DMA/HLA-DMB/PPP3R1/NFATC2/CD247/IL2RA/JAK3/NOTCH3/NFKBIE/NFATC3/DLL4/STAT5A/MAPK10/NOTCH1/MAPK13/NFKBIB	1.70888969156862
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	25/1861	93/9376	1.35434180952546	LAMA2/CDK6/CCND1/RARB/RB1/LAMA4/NFKB1/PIK3CD/BAX/CYCS/LAMB2/LAMC3/CKS1B/CKS2/CDK4/PIK3R2/AKT1/TP53/PIK3R3/CDKN1B/MAX/BCL2L1/POLK/DDB2/AKT2	1.70888969156862
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	30/1861	115/9376	1.31430039950471	MEF2C/NACA/EGR1/PDE4D/GNAI2/NR4A2/PDE4B/PRKCB/PLD1/ARRB2/PLCB1/MEF2A/PRKCA/MAFB/ARRB1/ITPR2/CREB1/LRP6/PLCB2/GNA13/KL/PRKACB/PRKACA/GNAI3/HBEGF/ITPR1/MEF2D/CREB3L1/ADCY4/PLCB4	1.68756008010764
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	28/1861	107/9376	1.31839479327263	CALM2/LDHB/CALM3/PLCB1/CALM1/PDE3B/PRMT1/ITPR2/CREB1/PPP3R1/CALML4/CAMK2D/PLCB2/PYGL/PRKACB/PRKACA/PDHB/AKT1/PGAM1/PCK2/ITPR1/CREB3L1/PRKAG1/G6PC3/SIRT1/PLCB4/PFKM/AKT2	1.64829802080857
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	13/1861	43/9376	1.52316209089887	ECHS1/HADHB/ACAA1/ALDH9A1/ADH5/ACAA2/HADHA/ECI2/ALDH3A2/ACAT1/ALDH7A1/ACADM/HADH	1.71101648574145
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	10/1861	31/9376	1.62521017143055	DPYD/ECHS1/CNDP2/ALDH9A1/HIBCH/SMOX/HADHA/ALDH3A2/ALDH7A1/ABAT	1.735048268478
NA	NA	hsa04981	Folate transport and metabolism	10/1861	31/9376	1.62521017143055	FOLR2/SLCO2B1/ABCC5/ABCC4/MTHFR/ABCG2/SLC46A1/TYMS/SHMT2/MTHFS	1.735048268478
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	26/1861	99/9376	1.32315090724548	C1QA/C1QC/FCGR3A/CFD/C1QB/FCGR2A/FCGR1A/C3AR1/HLA-DRA/ICAM1/C1R/ITGB2/HLA-DPA1/KRT10/C2/FPR1/ITGAM/HLA-DQA2/PTAFR/HLA-DMA/HLA-DMB/CFI/FCGR2B/KRT24/ITGAL/SELPLG	1.6084720950498
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	19/1861	69/9376	1.38731708836608	CALM2/JUN/PRKCB/CALM3/CALM1/PRKCA/PPP1CA/CREB1/PPP3R1/CALML4/CAMK2D/GRIN2C/PRKACB/PRKACA/GRIA4/PPP1CC/HDAC2/CREB3L1/SIRT1	1.60686976506954
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	15/1861	52/9376	1.45331294176001	CD36/PLTP/APOE/TSPO/NPC2/APOC1/LRP1/VDAC3/VDAC2/LIPA/MYLIP/VDAC1/NPC1/STARD3NL/LIPG	1.63114657946314
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	26/1861	100/9376	1.30991939817303	CXCL14/CCL3/CCL2/CCL4/CCL4L2/CCL3L1/CXCL8/CCL8/TNFRSF1B/TNFRSF1A/CX3CR1/CCR1/IL10RA/CSF1R/CCL13/CSF1/TNFRSF10B/CCL5/IL2RA/TNF/TNFRSF14/CXCL12/CXCL1/IL10RB/LTBR/IL6R	1.55046769674049
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	26/1861	100/9376	1.30991939817303	CD14/CD36/CR1/FCGR1A/HLA-DRA/CD4/KITLG/HLA-DPA1/ITGAM/CD37/HLA-DQA2/HLA-DMA/CSF1R/HLA-DMB/CD34/IL1B/CD33/CSF1/ITGA4/IL2RA/TNF/CD38/CD7/IL6R/CD24/CR1L	1.55046769674049
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	13/1861	44/9376	1.48854477065117	DYNLL1/RAB5C/RAB11A/CREB1/ARHGDIB/VAMP2/DCTN6/PRKACB/PRKACA/DCTN4/DCTN2/CREB3L1/DYNC2H1	1.61635843698902
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	28/1861	109/9376	1.29420406312084	CD36/PRKCB/SLC27A4/NFKB1/TNFRSF1A/SOCS3/PPP1CA/PIK3CD/CREB1/PYGL/TNF/PTPN1/PPP1CC/PIK3R2/IRS1/AKT1/RPS6KA3/PIK3R3/PCK2/CREB3L1/MAPK10/TBC1D4/PRKAG1/MLX/PTPA/RPS6KB2/G6PC3/AKT2	1.53739925415966
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	48/1861	200/9376	1.20915636754433	TUBA1B/JUN/CXCL8/FCGR2A/ARPC3/PYCARD/CYTH4/ACTB/MYO5A/NLRP3/ARPC5/NCKAP1L/TUBA1A/TLR4/ACTG1/BRK1/CASP1/WASF2/MYO1F/NFKB1/TNFRSF1A/RPS3/CLDN5/TUBB/BAX/ACTR2/CYCS/ARPC4/TUBB2A/ARPC1B/MYO1B/IL1B/GNA13/LPAR5/TNFRSF10B/TNF/CYFIP1/CASP4/TLR5/NCK2/TAB2/MAPK10/CLDN11/MAPK13/NAIP/IRAK1/NFKBIB/RIPK1	1.4878313944775
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	16/1861	57/9376	1.41421797373606	ELOVL2/HACD4/ECHS1/HADHB/HACD3/ACAA1/SCP2/PPT1/HSD17B4/CBR4/HSD17B12/ACAA2/HADHA/ACAT1/ACADM/HADH	1.56090346299341
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	49/1861	205/9376	1.20424109775757	HDAC9/CCND2/HLA-C/RBPJ/CDK6/JUN/HLA-A/CCND1/SYK/YWHAB/LYN/RB1/PMAIP1/YWHAH/NFKB1/EGR2/RANBP1/GTF2A2/PIK3CD/BAX/CREB1/VDAC3/REL/GTF2B/HDAC8/ATP6V0D1/PRKACB/PRKACA/JAK3/CDK4/CDKN2A/RASA2/PIK3R2/LTBR/HDAC2/TP53/HRAS/PIK3R3/EGR3/CDK1/CDKN1B/STAT5A/CREB3L1/IRF9/HLA-F/GTF2H3/RBL1/TBPL1/KRAS	1.47131631973937
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	10/1861	32/9376	1.57442235357335	LDHB/ECHS1/ACSS3/ACSS1/HIBCH/SUCLG1/HADHA/ECHDC1/DLD/ABAT	1.61969871879405
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	41/1861	169/9376	1.22227344845458	RPS27A/UBA52/UBB/GABARAP/HMGB1/HIF1A/VAMP8/GABARAPL2/TANK/WDFY3/CTSB/MAP2K2/PIK3CD/ATG7/C9orf72/VMP1/STX7/RRAGA/PRKACB/PRKACA/EIF2S1/PIK3R2/IRS1/AKT1/PPP2CB/HRAS/PIK3R3/ITPR1/MAPK10/NRBF2/BCL2L1/RPS6KB2/RRAGD/MTMR14/VPS11/RRAGB/SMCR8/KRAS/MLST8/ATG4C/AKT2	1.45099595065144
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	33/1861	133/9376	1.25006767321312	TYROBP/FCER1G/FCGR3A/HCST/HLA-C/HLA-A/LCP2/PRKCB/SYK/ICAM1/ITGB2/PRKCA/BID/VAV1/SH3BP2/MAP2K2/PIK3CD/ICAM2/RAC2/PPP3R1/NFATC2/TNFRSF10B/GZMB/CD247/TNF/LAT2/PIK3R2/PRF1/HRAS/PIK3R3/ITGAL/CD48/KRAS	1.44534401837247
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	27/1861	106/9376	1.28330274857299	FOLR2/PDGFC/IGF1/CCND1/RB1/PLAU/ETV5/NFKB1/HSP90AB1/MAP2K2/PIK3CD/CREB1/LEF1/SLC46A1/PIK3R2/AKT1/TP53/HRAS/PIK3R3/CDKN1B/TGFA/CREB3L1/PDGFRB/ERG/TCF7/KRAS/AKT2	1.4596817758514
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	34/1861	138/9376	1.24128371064333	CALM2/RPS6/MKNK1/CALM3/CALM1/PDE3B/PRKAR1A/SOCS3/PPP1CA/FLOT1/MAP2K2/PIK3CD/EIF4EBP1/CALML4/EIF4E/PYGL/PTPN1/PRKACB/PRKACA/PPP1CC/PIK3R2/IRS1/AKT1/HRAS/PIK3R3/EIF4E2/PCK2/MAPK10/PRKAG1/RPS6KB2/G6PC3/EXOC7/KRAS/AKT2	1.42093070708929
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	19/1861	71/9376	1.34823773376422	CCND2/CCND1/NFKB1/SOCS3/TNFRSF11A/MAP2K2/PIK3CD/CGA/PIK3R2/AKT1/HRAS/PIK3R3/IRF1/STAT5A/MAPK10/MAPK13/KRAS/AKT2/GALT	1.46568669609973
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	19/1861	71/9376	1.34823773376422	LDHB/HIF1A/MAP2K2/PIK3CD/PDHB/PIK3R2/AKT1/TP53/HRAS/PIK3R3/PGAM1/PDGFRB/TIGAR/FGFR3/SIRT6/PFKM/KRAS/SCO2/AKT2	1.46568669609973
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	35/1861	144/9376	1.22455071944594	CD14/C1QA/C1QC/C1QB/LY96/CXCL8/CCND1/C3AR1/TLR4/C2/NFKB1/TNFRSF1A/IL1B/MAP3K5/LEF1/TNF/ALDH9A1/ADIPOR1/ADH5/CXCL1/AKT1/TAB2/MAPK10/PRKAG1/MAP2K6/ALDH3A2/MAPK13/IL17RA/IRAK1/ALDH7A1/ACADM/RIPK1/SIRT1/TCF7/AKT2	1.35126998862365
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	11/1861	38/9376	1.45841228541531	IGF1/ATP1B3/ATP1B1/PRKCB/PRKCA/NR3C2/PIK3CD/PIK3R2/IRS1/PIK3R3/KRAS	1.409014440255
Genetic Information Processing	Transcription	hsa03040	Spliceosome	56/1861	243/9376	1.16105549695615	HSPA1A/SNRPD2/LSM3/SNRPF/SF3B5/LSM7/SF3B6/SNRPD1/SRSF3/DDX5/SNRPE/BCAS2/SNU13/SNRPG/LSM4/HNRNPA1/HNRNPA3/HSPA8/LSM5/CWC15/BUD31/LSM8/SNRPC/LSM6/MAGOH/SNRPB2/SRSF9/SNRPD3/SRSF10/TXNL4A/PRPF31/LSM2/PUF60/PQBP1/RBM8A/CDC40/HSPA6/SNRPA1/ALYREF/MAGOHB/THOC6/PPIE/SRSF8/SRSF6/U2SURP/SNRNP27/PRPF38B/SNRNP40/SNRPA/RBM22/ISY1/RP9/DHX38/PPIH/RBMX2/AQR	1.26580350096666
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	10/1861	34/9376	1.48180927395139	POLR2L/POLR2K/POLR2J/POLR2I/POLR2E/POLR2G/POLR1D/POLR3GL/POLR3K/POLR1C	1.40051903050045
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	21/1861	82/9376	1.29025831902596	NME2/GSTO1/DPYD/TYMP/NME3/MGST2/NME1/IMPDH2/DUT/NME4/ITPA/RRM1/IMPDH1/NME6/HPRT1/NAT1/UCK1/TK2/GSTA4/TK1/RRM2B	1.31366491250915
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	58/1861	254/9376	1.15044405048509	HGF/RYR2/CALM2/PDGFC/ATP2B1/SLC25A6/PRKCB/HRH1/SLC25A5/SLC8A1/CALM3/FGF7/PLCB1/CALM1/PRKCA/PTAFR/GNA14/ADRB1/HRH2/ITPR2/VDAC3/GNA15/PPP3R1/CALML4/CAMK2D/NFATC2/PLCB2/KDR/CYSLTR1/GRIN2C/VDAC2/VEGFB/RYR1/AGTR1/PRKACB/PRKACA/MCOLN2/PDE1C/ITPKB/VDAC1/MCOLN1/CD38/ORAI3/PTGFR/ADRB2/FGF10/NFATC3/ITPR1/TGFA/SLC25A4/CYSLTR2/VEGFC/FGF2/PDGFRB/ADCY4/FGFR3/TFEB/PLCB4	1.2095983181623
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	27/1861	110/9376	1.23663719407943	IGF1/GNAI2/ANAPC11/PDE3B/HSP90AB1/PIK3CD/CPEB4/PRKACB/CDC26/PRKACA/ANAPC13/GNAI3/ANAPC15/PIK3R2/AKT1/RPS6KA3/CDC27/PIK3R3/CDK1/MAPK10/ADCY4/MAPK13/CDC25B/ANAPC10/KRAS/CCNB2/AKT2	1.24230300002012
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	21/1861	83/9376	1.27471303807384	CCL4/CCL4L2/IFI16/PYCARD/POLR2L/NLRP3/CASP1/POLR2K/NFKB1/POLR2E/IL1B/IL33/CCL5/POLR1D/POLR3GL/G3BP1/CGAS/POLR3K/NFKBIB/RIPK1/POLR1C	1.25093482113261
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	47/1861	203/9376	1.16646858116961	SPP1/LAMA2/HGF/COL1A1/CCND2/COL1A2/COL6A1/COL6A2/JUN/PDGFC/IGF1/CCND1/PRKCB/ACTB/MYL12A/ACTG1/PRKCA/LAMA4/ITGB5/VAV1/ARHGAP5/MYL12B/TNXB/PPP1CA/PIK3CD/RAC2/KDR/LAMB2/VTN/VEGFB/ITGA4/LAMC3/PARVB/PPP1CC/TLN1/PIK3R2/AKT1/PARVG/COL6A6/HRAS/PIK3R3/ITGA9/MAPK10/VEGFC/ZYX/PDGFRB/AKT2	1.1932156270877
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	53/1861	232/9376	1.1509570308881	TMSB4X/PDGFC/ARPC3/PFN1/ACTB/ARPC5/NCKAP1L/FGF7/ITGB2/MYL12A/ACTG1/CFL1/MSN/BRK1/ITGB5/WASF2/IQGAP2/VAV1/ITGAM/MYL12B/PPP1CA/MAP2K2/ENAH/PIK3CD/ACTR2/RAC2/ARPC4/ARPC1B/GNA13/LPAR5/ITGA4/CXCL12/CYFIP1/PPP1CC/PIK3R2/AKT1/HRAS/PIK3R3/ABI2/FGF10/C9/ITGAX/GIT1/ITGAL/ITGA9/FGD3/FGF2/PDGFRB/PIKFYVE/IQGAP3/FGFR3/KRAS/AKT2	1.15857342172455
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	19/1861	75/9376	1.27633172129679	BCAT1/TKT/TALDO1/MAT2A/SDSL/ARG2/PHGDH/PGAM1/IDH3G/PRPS2/IDH3B/SDS/MAT2B/PRPS1/SHMT2/GOT1/ACO2/PYCR2/PFKM	1.19561370364831
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	24/1861	98/9376	1.23383302810646	CALM2/PRKCB/CALM3/INPP5D/PLCB1/CALM1/PRKCA/PIK3CD/ITPR2/CALML4/PLCB2/ITPKB/PIK3R2/MTMR6/PIK3R3/PI4K2A/ITPR1/PIP4P2/PIKFYVE/SYNJ1/PPIP5K2/MTMR14/PLCB4/PIP4P1	1.15793995549198
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	36/1861	154/9376	1.17774970864708	NME2/AKR1A1/IDO2/NME3/BCAT1/NME1/MOCS2/KYNU/HAAO/PPCS/GGCX/UROD/NME4/GCLM/AK1/MAT2A/PPCDC/IDO1/FECH/AK6/NME6/UROS/AFMID/MAT2B/NAPRT/SHMT2/ALDH3A2/CTPS2/DLD/CMPK2/AK9/MTHFD2L/RDH11/GSS/FLAD1/TPK1	1.10675382429693
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	26/1861	108/9376	1.21288833164169	SUMO2/SAP18/RAN/EEF1A1/SUMO1/SUMO3/UBE2I/MAGOH/KPNB1/RBM8A/KPNA2/PNN/ALYREF/MAGOHB/NUP54/THOC6/RANBP2/NUP42/KPNA5/PYM1/IPO13/NUP160/IPO5/NMD3/IPO8/NUP133	1.10729937810782
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	9/1861	32/9376	1.41698011821601	PMAIP1/BID/TNFRSF1A/BAX/CYCS/MAPK10/BCL2L1/BIRC5/HTRA2	1.17575884544825
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	40/1861	174/9376	1.15819575435281	HSPA1A/SEC61B/MAN1A1/DAD1/SEC61G/KRTCAP2/RBX1/TMEM258/HSP90AB1/HSPA8/BAX/UBXN1/OSTC/RAD23A/BAG1/SSR1/MAP3K5/VCP/NFE2L2/PRKN/EIF2S1/STUB1/DNAJB11/TXNDC5/UBE2J1/HSPA6/MAN1C1/ERO1B/SEC23B/UFD1/MAPK10/DERL2/TUSC3/YOD1/NGLY1/CAPN1/PLAA/DDIT3/MBTPS2/UBE2D4	1.04814813455291
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	21/1861	86/9376	1.23024630418755	AREG/JUN/PRKCB/PRKCA/MAP2K2/PIK3CD/EIF4EBP1/CAMK2D/HBEGF/PIK3R2/AKT1/HRAS/PIK3R3/CDKN1B/TGFA/NCK2/STAT5A/MAPK10/RPS6KB2/KRAS/AKT2	1.06740287629861
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	39/1861	170/9376	1.15581123368208	HGF/WNT2/CDK6/CCND1/PRKCB/ACTB/RB1/ACTG1/PRKCA/GSTO1/MAP2K2/MGST2/PIK3CD/BAX/LRP6/NFE2L2/LEF1/FZD2/CDK4/CDKN2A/PIK3R2/AKT1/TP53/HRAS/PIK3R3/TGFB3/TGFA/BCL2L1/POLK/DDB2/RPS6KB2/ACTL6A/GSTA4/FZD7/FZD1/KEAP1/TCF7/KRAS/AKT2	1.02019237663962
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	15/1861	59/9376	1.28088598256815	HPGDS/GPX4/LAP3/GSTO1/MGST2/SRM/GCLM/ODC1/GSTK1/SMS/RRM1/GGCT/GSTA4/GSS/RRM2B	1.07699170145125
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	15/1861	59/9376	1.28088598256815	CCND1/MAP2K2/PIK3CD/BAX/LEF1/PIK3R2/AKT1/TP53/HRAS/PIK3R3/POLK/DDB2/TCF7/KRAS/AKT2	1.07699170145125
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	31/1861	133/9376	1.17430599604869	CCND2/IGF1/CCND1/GABARAP/KLF2/GABARAPL2/HOMER3/PRMT1/MAP2K2/PIK3CD/CAT/SGK3/ATM/S1PR1/PIK3R2/IRS1/AKT1/HRAS/PIK3R3/TGFB3/PCK2/CDKN1B/CDKN2D/MAPK10/PRKAG1/MAPK13/G6PC3/SIRT1/KRAS/CCNB2/AKT2	1.0074558039364
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	32/1861	138/9376	1.16826702178196	CALM2/IGF1/YWHAB/CALM3/ANAPC11/CALM1/YWHAH/RBX1/PPP1CA/ITPR2/PPP3R1/CALML4/CAMK2D/CPEB4/PRKACB/CDC26/PRKACA/ANAPC13/PPP1CC/ANAPC15/PTTG1/RPS6KA3/PPP2CB/CDC27/PPP2R5C/CDK1/ITPR1/ADCY4/MAPK13/PPP2R5B/ANAPC10/CCNB2	0.990932117228099
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	9/1861	33/9376	1.37404132675492	VAMP8/VAMP5/STX7/VAMP2/VAMP3/STX2/BET1/USE1/BET1L	1.07109432090116
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	36/1861	158/9376	1.1479332603269	CCND2/CDK6/CCND1/YWHAB/ANAPC11/RB1/YWHAH/RBX1/PCNA/HDAC8/CDC26/ANAPC13/ATM/CDK4/ANAPC15/CDKN2A/PTTG1/MCM5/HDAC2/TP53/PPP2CB/CDC27/PPP2R5C/CDK1/TGFB3/CDKN1B/CDKN2D/MCM3/E2F4/BUB3/CDKN2C/PPP2R5B/RBL1/CDC25B/ANAPC10/CCNB2	0.933190594039138
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	4/1861	12/9376	1.67938384381157	CD209/NCAM2/FCGR2B/NPC1	1.17184310133735
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	38/1861	168/9376	1.13958189401499	CYBB/FTL/PYCARD/HMGB1/SLC25A6/PPIA/SLC25A5/NLRP3/TLR4/CASP1/BID/CHMP2A/TNFRSF1A/HSP90AB1/BAX/CHMP5/VDAC3/CAMK2D/CHMP4A/IL1B/PARP1/IL33/TNFRSF10B/VDAC2/PYGL/TNF/VDAC1/JAK3/GLUD1/CYLD/PLA2G4C/SLC25A4/STAT5A/MAPK10/IRF9/PPID/CAPN1/RIPK1	0.908438235178874
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	10/1861	38/9376	1.32582935037756	ENPP1/NAMPT/NT5C/CD38/NNT/NAPRT/PNP/SIRT1/NUDT12/SIRT6	1.00149641348497
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	17/1861	70/9376	1.22355108620557	CD36/TNFRSF1B/NFKB1/TNFRSF1A/SOCS3/TNF/ADIPOR1/APPL1/IRS1/AKT1/NFKBIE/PCK2/MAPK10/PRKAG1/G6PC3/NFKBIB/AKT2	0.934197310407175
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	23/1861	98/9376	1.18242331860202	CALM2/ATP1B3/ATP1B1/NR4A2/ATP2B1/PRKCB/CALM3/PLCB1/CALM1/PRKCA/KCNJ5/ITPR2/CREB1/CALML4/CAMK2D/PLCB2/AGTR1/PRKACB/PRKACA/ITPR1/CREB3L1/ADCY4/PLCB4	0.903359337785914
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	21/1861	89/9376	1.1887773276419	GNG2/GNG11/GNAI2/GABARAP/GNG5/PRKCB/GNG10/PRKCA/GABARAPL2/GNGT1/GNB4/GNB2/GABRA3/PRKACB/PRKACA/GNAI3/SLC12A5/GNG7/ADCY4/TRAK2/ABAT	0.890433409789585
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/1861	21/9376	1.4394718661242	CHSY3/CSGALNACT2/B3GAT3/B3GALT6/DSEL/CHST14	1.00325922463973
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	23/1861	99/9376	1.17047964871716	JUN/PDGFC/PRKCB/PLD1/HIF1A/WAS/PRKCA/WASF2/MAP2K2/PLPP3/PIK3CD/EIF4EBP1/RAC2/PIK3R2/AKT1/HRAS/PIK3R3/PLA2G4C/MAPK10/PDGFRB/RPS6KB2/KRAS/AKT2	0.848556360471962
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	12/1861	48/9376	1.25953788285868	ATP1B3/ATP1B1/PRKCB/PLCB1/PIK3CD/PLCB2/PIK3R2/AKT1/PIK3R3/G6PC3/PLCB4/AKT2	0.897059892661637
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	8/1861	30/9376	1.34350707504926	GPAA1/PIGC/DPM2/PIGP/PIGX/PIGS/PIGH/PIGF	0.937729886675848
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	10/1861	39/9376	1.2918337260089	MTHFR/MAT2A/AHCY/TYMS/MAT2B/SHMT2/MTHFS/DLD/ALDH7A1/MTHFD2L	0.908779321497396
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	25/1861	109/9376	1.15553934207218	JUN/RUNX1/HLA-DRA/CD4/HIF1A/HLA-DPA1/NFKB1/HLA-DQA2/HSP90AB1/HLA-DMA/HLA-DMB/PPP3R1/NFATC2/IL1B/CD247/IL2RA/JAK3/NFKBIE/AHR/IL6R/NFATC3/STAT5A/MAPK10/MAPK13/NFKBIB	0.812789823354803
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	24/1861	105/9376	1.15157749289936	LAMA2/RYR2/IGF1/ACTB/SLC8A1/DTNA/ACTG1/TPM3/ITGB5/ADRB1/CACNB4/SGCE/ITGA4/TNF/PRKACB/PRKACA/EMD/CACNA2D4/TGFB3/SGCA/ITGA9/CACNA2D1/ADCY4/SGCB	0.777249427513011
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	26/1861	115/9376	1.13906034623741	GNG2/GNG11/GNAI2/GNG5/PRKCB/GNG10/PLCB1/PRKCA/GNGT1/GNB4/KCNJ5/GNB2/ITPR2/PLCB2/ALOX5/PRKACB/PRKACA/GNAI3/TRPC1/HRAS/PLA2G4C/ITPR1/GNG7/PTGS1/PLCB4/KRAS	0.746650940966083
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	6/1861	22/9376	1.37404132675492	HNMT/CNDP2/ASPA/ALDH9A1/ALDH3A2/ALDH7A1	0.874030481440797
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/1861	31/9376	1.30016813714444	PGLS/TKT/TALDO1/RBKS/PRPS2/GPI/PRPS1/PFKM	0.833009810785815
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	13/1861	54/9376	1.21288833164169	HLA-C/CD86/HLA-A/HLA-DRA/CD28/HLA-DPA1/HLA-DQA2/HLA-DMA/HLA-DMB/CGA/GZMB/PRF1/HLA-F	0.780707805460546
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	17/1861	73/9376	1.17326816485466	PPIA/CD4/RAN/FEZ1/BICD1/SERINC5/APOBEC3C/CHMP4A/PSIP1/SUPT4H1/PIN1/FURIN/RANBP2/MLLT1/NELFCD/MAP1S/BICD2	0.739542313482095
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	18/1861	78/9376	1.16265035340801	LSM3/BTG2/LSM7/LSM4/LSM5/LSM8/LSM6/C1D/PABPC4L/NUDT16/CNOT7/LSM2/XRN1/EXOSC8/TENT4B/MPHOSPH6/EXOSC6/PFKM	0.717797388564203
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1861	27/9376	1.30618743407567	ELOVL2/HACD4/HACD3/ACAA1/SCP2/HSD17B4/HSD17B12	0.792831684393045
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	12/1861	50/9376	1.20915636754433	CD86/HLA-DRA/CD28/HLA-DPA1/TNFSF13B/HLA-DQA2/HLA-DMA/HLA-DMB/ITGA4/CXCL12/LTBR/TNFSF13	0.737908851094359
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	19/1861	83/9376	1.15331179635252	HMGCLL1/PMVK/CAT/NUDT19/ACAA1/SCP2/HSD17B4/GSTK1/PEX2/AMACR/PXMP2/MPV17/ECI2/PEX16/PHYH/PEX10/CROT/FAR1/NUDT12	0.698121450268453
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	10/1861	41/9376	1.22881744669139	GATM/GAMT/GRHPR/SDSL/PHGDH/PGAM1/SDS/SHMT2/DLD/ALDH7A1	0.730664882550135
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	18/1861	79/9376	1.1479332603269	SYT1/CLTA/CLTC/ATP6V1F/AP2S1/ATP6V1G1/SLC1A6/ATP6V0B/AP2M1/ATP6V0C/ATP6V1D/ATP6V1B2/VAMP2/ATP6V0D1/STX2/NAPA/ATP6V0A1/ATP6V1A	0.657055857550678
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/1861	23/9376	1.31430039950471	PMVK/IDI1/ICMT/GGPS1/FDPS/ACAT1	0.750978867552609
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6/1861	23/9376	1.31430039950471	ATP1B3/ATP1B1/MDH1/GLUD1/AQP1/PCK2	0.750978867552609
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	13/1861	56/9376	1.16957089122592	ST6GAL1/MAN1A1/DAD1/KRTCAP2/TMEM258/OSTC/MGAT4B/DPM3/MAN1C1/DPM2/ALG2/TUSC3/MAN2A2	0.633332379782899
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1861	10/9376	1.51144545943041	SELENBP1/SQOR/TST	0.80522376303736
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	15/1861	66/9376	1.14503443896243	MAF/JUN/IL12RB2/HLA-DRA/TLR4/HLA-DPA1/NFKB1/HLA-DQA2/TLR2/HLA-DMA/HLA-DMB/IL1B/TNF/TLR5/TGFB3	0.588386363459957
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	32/1861	148/9376	1.08933006085075	WNT2/CDK6/JUN/IGF1/CCND1/FGF7/RB1/MAP2K2/PIK3CD/BAX/LRP6/LEF1/FZD2/CDK4/PIK3R2/AKT1/TP53/HRAS/NOTCH3/PIK3R3/FGF10/DLL4/NOTCH1/FGF2/POLK/DDB2/RPS6KB2/FZD7/FZD1/TCF7/KRAS/AKT2	0.54509101939663
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	46/1861	217/9376	1.06799525551151	JUN/GNAI2/CCND1/PRKCB/ARRB2/FGF7/RB1/PRKCA/GSTO1/NFKB1/ADRB1/HSP90AB1/MAP2K2/ARRB1/MGST2/PIK3CD/EIF4EBP1/CREB1/KPNB1/PRKACB/AIP/PRKACA/GNAI3/KPNA2/PIK3R2/AKT1/EPHX1/RPS6KA3/PAQR8/HRAS/PIK3R3/AHR/ADRB2/FGF10/DLL4/STAT5A/CREB3L1/FGF2/KPNA5/RPS6KB2/BIRC5/ADCY4/GSTA4/KRAS/PAQR7/AKT2	0.504288169505489
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	38/1861	178/9376	1.07556043929505	WNT2/SERPINF1/CCND2/JUN/RSPO2/PRICKLE1/CCND1/PRKCB/RSPO3/PLCB1/PRKCA/RBX1/BAMBI/FRZB/RAC2/LRP6/PPP3R1/CAMK2D/NFATC2/PLCB2/TLE4/LEF1/PRKACB/PRKACA/FZD2/INVS/TP53/ZNRF3/NFATC3/MAPK10/DKK2/RUVBL1/CBY1/FZD7/FZD1/SIRT1/PLCB4/TCF7	0.506468110005336
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	32/1861	149/9376	1.08201912084504	FCER1G/CXCL8/PDGFC/LPAR6/SYK/CYTH4/PLD1/KITLG/PLCB1/PRKCA/PIK3R5/MAP2K2/PLPP3/PIK3CD/PIK3CG/PLCB2/GNA13/LPAR5/AGPAT3/AGTR1/AGPAT2/PIK3R2/PTGFR/AKT1/HRAS/PIK3R3/PLA2G4C/PDGFRB/ADCY4/PLCB4/KRAS/AKT2	0.502194920888232
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	19/1861	86/9376	1.11307998950302	LAMA2/RYR2/ACTB/SLC8A1/GJA1/DTNA/ACTG1/ITGB5/CACNB4/SGCE/ITGA4/LEF1/EMD/CACNA2D4/SGCA/ITGA9/CACNA2D1/SGCB/TCF7	0.524229504891511
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	4/1861	15/9376	1.34350707504926	AK1/ACP1/NTPCR/TPK1	0.662543695331963
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	7/1861	29/9376	1.21610554207045	RASSF4/MOB1A/DCHS1/RASSF2/RASSF1/MOB1B/FAT4	0.579993484057246
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	36/1861	170/9376	1.066902677245	TUBA1B/JUN/RUNX1/ARPC3/CCND1/MYL6/MAGI1/ACTB/ARPC5/TUBA1A/MYL12A/ACTG1/MSN/WAS/MYL12B/CLDN5/RAB13/PCNA/ACTR2/GATA4/MAP3K1/ARPC4/ARPC1B/MAP3K5/PRKACB/PRKACA/RAPGEF6/CDK4/JAM3/PPP2CB/MAPK10/MYL6B/PRKAG1/CLDN11/SYNPO/DLG3	0.438053147319233
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	10/1861	44/9376	1.14503443896243	MAN1A1/DAD1/KRTCAP2/TMEM258/OSTC/MGAT4B/MAN1C1/ALG2/TUSC3/MAN2A2	0.479848835058534
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	26/1861	122/9376	1.07370442473199	CD36/IGF1/CCND1/EEF2/PIK3CD/EIF4EBP1/CREB1/ADIPOR1/PIK3R2/IRS1/AKT1/PPP2CB/PIK3R3/PPP2R5C/PFKFB2/PCK2/STRADB/CREB3L1/PRKAG1/PPP2R3C/RPS6KB2/G6PC3/PPP2R5B/SIRT1/PFKM/AKT2	0.407758535618397
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	11/1861	49/9376	1.13101360909759	JUN/GNAI2/NFKB1/CREB1/BDNF/GRIN2C/PRKACB/PRKACA/GNAI3/CREB3L1/DLG4	0.457549193808533
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1861	16/9376	1.25953788285868	GLA/NAGA/FUT9/B3GALNT1	0.517031682997018
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	19/1861	89/9376	1.07556043929505	SPP1/CD36/LAMA2/COL1A1/COL1A2/COL6A1/COL6A2/FREM1/LAMA4/ITGB5/TNXB/CD47/LAMB2/VTN/ITGA4/LAMC3/COL6A6/ITGA9/HMMR	0.356406886606219
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	21/1861	99/9376	1.06869880969827	LAMA2/RYR2/IGF1/ACTB/SLC8A1/DTNA/ACTG1/TPM3/ITGB5/CACNB4/SGCE/ITGA4/TNF/EMD/CACNA2D4/TGFB3/SGCA/ITGA9/CACNA2D1/PRKAG1/SGCB	0.341945870753403
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	28/1861	134/9376	1.05274808119531	PRKG1/CALM2/MYL6/PRKCB/GUCY1A2/CALM3/GUCY1A1/PLCB1/CALM1/PRKCA/RAMP2/PPP1R14A/PPP1CA/MAP2K2/ITPR2/CALML4/PLCB2/GNA13/GUCY1B1/AGTR1/PRKACB/PRKACA/PPP1CC/PLA2G4C/ITPR1/MYL6B/ADCY4/PLCB4	0.306034519115633
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	14/1861	65/9376	1.08514032984748	AKR1B1/GK/AKR1A1/PLPP3/GLA/AGPAT3/ALDH9A1/AGPAT2/GPAT2/ABHD16A/LIPG/ALDH3A2/MBOAT1/ALDH7A1	0.3427584542997
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	11/1861	51/9376	1.08666013423102	ENPP2/PLD1/PLPP3/PLD4/LPCAT2/CEPT1/PLAAT3/PLB1/PLA2G4C/TMEM86A/PAFAH1B3	0.30879791370841
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	12/1861	56/9376	1.07960389959315	CCND2/DISP1/CCND1/ARRB2/ARRB1/GAS1/GRK2/SMURF2/PRKACB/PRKACA/GLI2/SMO	0.297313570771782
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1861	17/9376	1.18544741916111	SCP2/HSD17B4/AMACR/CH25H	0.380824484661538
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/1861	17/9376	1.18544741916111	INMT/SEPHS2/SEPHS1/KYAT3	0.380824484661538
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	32/1861	156/9376	1.03346698080712	CDK6/CD81/CCND1/EIF3E/YWHAB/RB1/YWHAH/NFKB1/BID/TNFRSF1A/SOCS3/CLDN5/MAP2K2/PIK3CD/BAX/CYCS/TNF/EIF2S1/CDK4/PIK3R2/AKT1/TP53/PPP2CB/HRAS/PIK3R3/IRF9/CLDN11/IFIT1B/RIPK1/RSAD2/KRAS/AKT2	0.209752770367232
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	6/1861	27/9376	1.11958922920771	HMGCLL1/ECHS1/HADHA/ACAT1/HADH/ABAT	0.309660421938109
Human Diseases	Immune disease	hsa05310	Asthma	7/1861	32/9376	1.10209564750134	FCER1G/HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DMA/HLA-DMB/TNF	0.28787909875666
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	14/1861	67/9376	1.05274808119531	LDHB/AKR1A1/ACSS1/ALDH9A1/ADH5/PDHB/PGAM1/PCK2/GPI/ALDH3A2/G6PC3/DLD/ALDH7A1/PFKM	0.21561892900161
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	32/1861	157/9376	1.02688438857268	BMP5/WNT2/CCND2/AREG/CCND1/BMP4/YWHAB/ACTB/ITGB2/ACTG1/YWHAH/ID2/PPP1CA/MOB1A/ID1/LEF1/FZD2/PPP1CC/GDF6/PPP2CB/GLI2/TGFB3/BMP7/BIRC5/DLG4/RASSF1/DLG3/MOB1B/FZD7/FZD1/BMPR1A/TCF7	0.169045033121797
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	19/1861	93/9376	1.02929977523935	PTPRJ/ACTB/MYL12A/ACTG1/WAS/WASF2/MYL12B/LMO7/RAC2/CDH5/PTPRM/LEF1/SMURF2/PTPRB/PTPN1/ACP1/ARHGAP29/CCM2/TCF7	0.141304476428726
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	16/1861	78/9376	1.03346698080712	ARPC3/CLTA/CLTC/ACTB/ARPC5/RHOG/ACTG1/WASF2/ELMO1/PIK3CD/ACTR2/ARPC4/ARPC1B/PIK3R2/PIK3R3/SEPTIN1	0.147694185245443
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	13/1861	63/9376	1.03961856997859	PTGDS/HPGDS/GPX4/LTC4S/TBXAS1/ALOX5/PTGES2/PLAAT3/PLB1/PLA2G4C/PRXL2B/CBR1/PTGS1	0.157006850283924
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	13/1861	63/9376	1.03961856997859	WNT2/BMP4/BAX/LEF1/FZD2/TP53/GLI2/POLK/DDB2/FZD7/FZD1/SMO/TCF7	0.157006850283924
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1861	38/9376	1.06066348030204	NAGK/RENBP/GPI/GNPDA1/UAP1L1/AMDHD2/FPGT/GALT	0.186460359944906
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	7/1861	33/9376	1.06869880969827	BCAT1/PDHB/IDH3G/IDH3B/GOT1/DLD/ACO2	0.196723997208742
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/1861	18/9376	1.11958922920771	MANBA/NEU1/MAN2B1/FUCA1	0.25271506444114
Cellular Processes	Cell motility	hsa04814	Motor proteins	39/1861	194/9376	1.01282427693791	TUBA1B/DYNLL1/MYL6/TNNT3/ACTB/MYO5A/TUBA1A/KIF1B/MYL12A/ACTG1/TPM3/DYNLRB1/MYO1F/MYL12B/CAPZA2/CAPZB/TUBB/TUBB2A/DCTN3/DYNLT1/MYO1B/MYO7A/DNAH8/TNNT1/KIF5B/DCTN6/CAPZA1/DYNLT3/DCTN4/KIF20B/ACTR1A/DCTN2/MYL4/MYL6B/KIF13B/DYNC2H1/CENPE/STARD9/TUBG1	0.0898171853072673
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	31/1861	155/9376	1.00763030628694	WNT2/CDK6/GNAI2/CCND1/PLCB1/RB1/MAP2K2/ITPR2/CREB1/CAMK2D/PLCB2/LEF1/AGTR1/PRKACB/AIP/PRKACA/FZD2/FH/GNAI3/CDK4/CDKN2A/AHR/CDKN1B/ITPR1/CREB3L1/ADCY4/CDKN2C/FZD7/FZD1/PLCB4/TCF7	0.0476664865438378
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	9/1861	44/9376	1.03053099506619	GTF2I/GTF2H5/TAF10/GTF2A2/GTF2B/TAF9/TAF9B/GTF2H3/TBPL1	0.101012301081705
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	7/1861	34/9376	1.03726649176597	BHLHE41/RBX1/CREB1/PER3/NR1D2/DBP/PRKAG1	0.108325915958802
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	15/1861	75/9376	1.00763030628694	ATP1B3/ATP1B1/PRKCB/PLCB1/PRKCA/ITPR2/CREB1/CGA/PLCB2/PRKACB/PRKACA/ITPR1/CREB3L1/ADCY4/PLCB4	0.0330143014956426
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/1861	20/9376	1.00763030628694	LBR/LIPA/CYP2R1/EBP	0.0169983275961347
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1861	20/9376	1.00763030628694	NPL/NANS/UAP1L1/CYB5R4	0.0169983275961347
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	20/1861	103/9376	0.978281850764022	COL3A1/COL15A1/COL1A1/COL14A1/SLC16A10/COL1A2/COL6A1/COL6A2/ATP1B3/ATP1B1/SLC8A1/COL5A2/KCNQ1/ELN/COL21A1/COL8A2/COL6A6/KCNE3/SLC7A7/SLC36A1	-0.110287331273334
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	29/1861	150/9376	0.974042629410711	HGF/WNT2/CCND1/RARB/FGF7/RB1/MAP2K2/PIK3CD/BAX/LRP6/LEF1/FZD2/PIK3R2/AKT1/TP53/HRAS/PIK3R3/TGFB3/FGF10/CDKN1B/FGF2/POLK/DDB2/RPS6KB2/FZD7/FZD1/TCF7/KRAS/AKT2	-0.159475485954041
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/1861	32/9376	0.944653412144009	GABARAP/GABARAPL2/ATG7/PPP2CB/MLST8/ATG4C	-0.156060774589137
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	9/1861	49/9376	0.925374771079845	ST6GAL1/GXYLT2/GALNT1/B3GLCT/RFNG/GALNT11/LFNG/GALNT10/MFNG	-0.260619591852939
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	44/1861	233/9376	0.951410589627156	DCN/COL3A1/LAMA2/COL1A1/COL1A2/COL6A1/VIM/COL6A2/VCAN/ATP1B3/ATP1B1/TNNT3/ACTB/COL5A2/DTNA/ACTG1/TPM3/ANK2/ITGB5/CAPZA2/ELN/LBR/CAPZB/FBLN2/SGCE/TNNT1/ITGA4/FMNL1/SDC2/CAPZA1/ANK3/EMD/TLN1/SPTAN1/COL6A6/SDC3/SGCA/ITGA9/MYL4/ZYX/FMNL3/MYOM2/SGCB/LMNB2	-0.373739983351654
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/1861	28/9376	0.899669916327627	AKR1B1/PCBD1/MOCS2/QDPR/CBR1	-0.264572786001778
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1861	17/9376	0.889085564370832	NRP2/CD209/PCDH11X	-0.22776770354139
Organismal Systems	Digestive system	hsa04978	Mineral absorption	11/1861	61/9376	0.908519128619374	FTL/SLC40A1/ATP1B3/ATP1B1/ATOX1/ATP2B1/SLC8A1/SLC46A1/CYBRD1/ATP7A/MT1G	-0.356695896306978
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	13/1861	72/9376	0.909666248731268	CXCL8/NFKB1/TANK/MAP3K1/PIN1/TNF/CASP10/CYLD/MAPK10/RNF125/MAPK13/NFKBIB/RIPK1	-0.382891543886421
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	14/1861	78/9376	0.90428360820623	INPP5D/PLCB1/PIK3CD/PIK3CG/PLCB2/ITPKB/MTMR6/PI4K2A/PIKFYVE/SYNJ1/PPIP5K2/MTMR14/FIG4/PLCB4	-0.422409018073318
Organismal Systems	Sensory system	hsa04744	Phototransduction	5/1861	29/9376	0.868646815764606	CALM2/CALM3/CALM1/GNGT1/CALML4	-0.352531407740875
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	11/1861	62/9376	0.893865594286804	RBPJ/PSENEN/TLE4/HDAC2/NOTCH3/DLL4/NOTCH1/RFNG/NRARP/LFNG/MFNG	-0.417232617805944
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	42/1861	226/9376	0.93629364743477	RYR2/CALM2/JUN/PDE4D/ATP1B3/GNAI2/ATP1B1/ATP2B1/PDE4B/PDE3A/PLD1/CALM3/CALM1/PDE3B/NFKB1/VAV1/ADRB1/PPP1CA/MAP2K2/PIK3CD/CREB1/RAC2/CALML4/CAMK2D/CGA/BDNF/GRIN2C/ABCC4/PRKACB/PRKACA/GRIA4/GNAI3/PPP1CC/PIK3R2/AKT1/FXYD1/PIK3R3/ADRB2/CREB3L1/MAPK10/ADCY4/AKT2	-0.482414936126266
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/1861	52/9376	0.871987765056008	IGF1/HSD17B2/CGA/HSD17B1/ALOX5/PRKACB/PRKACA/PLA2G4C/ADCY4	-0.460623776474638
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1861	24/9376	0.839691921905785	B3GAT3/HS2ST1/B3GALT6/NDST2	-0.391293930583059
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	11/1861	63/9376	0.879677251520347	PRDM6/ECHS1/ALDH9A1/KMT5A/TMLHE/HADHA/ALDH3A2/ACAT1/DLD/ALDH7A1/HADH	-0.476834367482306
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	7/1861	41/9376	0.860172212683975	SSBP1/RPA3/SEM1/POLD4/ATM/RPA2/POLD2	-0.446501153097393
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	26/1861	144/9376	0.909666248731268	WNT2/IGF1/BMP4/ID2/ACVR2A/MAP2K2/SMAD5/PIK3CD/ID1/FZD2/JAK3/PIK3R2/AKT1/HRAS/PIK3R3/MEIS1/FGF2/DUSP9/MAPK13/FZD7/FGFR3/FZD1/BMPR1A/TCF7/KRAS/AKT2	-0.543597844399781
NA	NA	hsa04081	Hormone signaling	40/1861	219/9376	0.920210325376203	GNG2/SLC40A1/SLC16A10/PRKG1/IGF1/GNG11/GNAI2/GNG5/GNG10/GUCA2A/PLCB1/RAMP2/GNGT1/GNB4/GNA14/GNB2/ADRB1/SMAD5/PIK3CD/GNA15/CGA/PLCB2/GNA13/AGTR1/ADIPOR1/PRKACB/PRKACA/GNAI3/APPL1/PIK3R2/IRS1/THRA/PIK3R3/ADRB2/GNG7/STAT5A/ADCY4/CSHL1/PLCB4/BMPR1A	-0.594547389647344
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	15/1861	86/9376	0.878747360133962	RYR2/ATP1B3/ATP1B1/PRKCB/PLCB1/PRKCA/CREB1/CAMK2D/PLCB2/VAMP2/PRKACB/PRKACA/CREB3L1/ADCY4/PLCB4	-0.56211723792268
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/1861	31/9376	0.812605085715276	AKR1A1/KL/ALDH9A1/ALDH3A2/ALDH7A1	-0.520047875752465
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	11/1861	65/9376	0.852610259165875	PLCB1/ITPR2/CREB1/PLCB2/AGTR1/PRKACB/PRKACA/ITPR1/CREB3L1/ADCY4/PLCB4	-0.593362509147428
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/1861	37/9376	0.816997545638061	NAGK/GPI/NANS/UAP1L1/FPGT/GALT	-0.555011422146887
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	18/1861	104/9376	0.871987765056008	PLD1/SGMS1/PLPP3/PLD4/PLA2G15/LPCAT2/AGPAT3/ETNK1/AGPAT2/CEPT1/GPAT2/PLAAT3/PLB1/PLA2G4C/PTDSS1/MBOAT1/GPD1L/PNPLA6	-0.653244512826662
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/1861	26/9376	0.77510023560534	ACAA1/PLAAT3/PLB1/PLA2G4C	-0.571431531912714
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1861	32/9376	0.787211176786674	AKR1B1/GLA/G6PC3/PFKM/GALT	-0.600000647934934
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	6/1861	38/9376	0.795497610226534	PTPRC/CD4/RFXANK/JAK3/BTK/BLNK	-0.628575693595158
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	54/1861	298/9376	0.912953633213001	CXCL14/CCL3/CCL2/CCL4/BMP5/CCL4L2/CCL3L1/EDA/CXCL8/IL12RB2/CCL8/CD4/BMP4/TNFRSF1B/TNFSF13B/TNFRSF1A/TNFSF12/CX3CR1/TNFRSF11A/CCR1/ACVR2A/IL10RA/CSF1R/CXCL16/CCL13/IL1B/IL33/CSF1/TNFRSF10B/CCL5/LTB/CNTFR/TNFRSF12A/IL2RA/TNF/TNFRSF14/CXCL12/TNFRSF25/CXCL1/IL10RB/LTBR/IL1RN/GDF6/TGFB3/IL6R/ACVRL1/TNFSF9/OSM/BMP7/TNFSF8/IL17RA/TNFSF13/CSHL1/BMPR1A	-0.759902763743603
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	17/1861	102/9376	0.839691921905785	RYR2/ATP1B3/ATP1B1/ATP2B1/PRKCB/PLCB1/PRKCA/RAB11A/KCNQ1/ITPR2/PLCB2/CD38/TRPC1/ITPR1/ADCY4/RAB3D/PLCB4	-0.810058306784181
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/1861	46/9376	0.766675233044413	FTL/BLVRB/BLVRA/UROD/FECH/UROS/HCCS	-0.789392992839801
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	12/1861	76/9376	0.795497610226534	CD36/PLTP/FABP5/DBI/SLC27A4/MMP1/GK/ME1/ACAA1/SCP2/PCK2/ACADM	-0.890754534001936
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/1861	47/9376	0.750362994043468	SOCS3/PIK3CD/TNF/PIK3R2/IRS1/PIK3R3/MAPK10	-0.853757791089913
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1861	35/9376	0.719735933062102	AKR1B1/PFKFB2/TIGAR/FPGT/PFKM	-0.826607018126449
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1861	16/9376	0.629768941429339	MIF/GOT1	-0.737546231024731
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1861	23/9376	0.657150199752354	GLUD1/ARG2/GOT1	-0.819193851284809
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1861	23/9376	0.657150199752354	ATP6AP2/AGTR1/NLN	-0.819193851284809
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1861	17/9376	0.592723709580554	GLUD1/CA1	-0.836359891744318
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	8/1861	55/9376	0.732822040935958	ASAH1/SGMS1/NEU1/PLPP3/GLA/ACER3/CERS2/GALC	-0.98888331906295
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/1861	37/9376	0.680831288031718	ASPA/GLUD1/NIT2/GOT1/ABAT	-0.967977622769791
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	16/1861	103/9376	0.782625480611217	SAP18/PPP1CA/MAGOH/PABPC4L/RNMT/RBM8A/PPP1CC/PNN/ALYREF/PPP2CB/MAGOHB/PPP2R5C/PYM1/PPP2R3C/PPP2R5B/PCF11	-1.10385352682345
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1861	18/9376	0.559794614603857	MMADHC/HCFC1	-0.930238726971805
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1861	26/9376	0.581325176704005	SLC46A1/PLB1/BTD	-1.06378055260869
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	14/1861	94/9376	0.750362994043468	CCL2/S100A9/JUN/CXCL8/MMP1/NFKB1/HSP90AB1/IL1B/TNF/CXCL1/TAB2/MAPK10/MAPK13/IL17RA	-1.2104488502565
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1861	19/9376	0.530331740151022	ARSB/HYAL2	-1.01975074112876
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/1861	19/9376	0.530331740151022	PDHB/DLD	-1.01975074112876
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	12/1861	83/9376	0.72840745032791	SCML1/CBX6/HDAC2/RBBP7/DCAF7/MAX/HCFC1/SCML2/CBX4/EED/UBE2D4/FBRS	-1.23672534775609
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1861	12/9376	0.419845960952893	GGCX	-1.00068542189076
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1861	28/9376	0.539801949796576	B3GNT5/FUT9/B3GALNT1	-1.2135530620357
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1861	36/9376	0.559794614603857	AKR1B1/AKR1A1/CRYL1/KL	-1.31682328035282
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1861	36/9376	0.559794614603857	ENPP1/PYGL/GPI/G6PC3	-1.31682328035282
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	17/1861	117/9376	0.732039111405044	ACTB/ACTG1/CDK2AP1/BAZ2B/MEAF6/EPC1/HDAC2/RBBP7/POLE3/MCRS1/BCL7C/TFPT/RUVBL1/ING3/ACTL6A/BCL7B/DPF2	-1.45136494876499
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1861	43/9376	0.585831573422641	CD36/SLC27A4/PLPP3/AGPAT2/ACAT1	-1.35454960914675
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/1861	37/9376	0.544665030425374	MIF/ADH5/GSTZ1/GOT1	-1.3809438233927
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	9/1861	70/9376	0.647762339755892	HPGDS/SULT1A1/GSTO1/MGST2/EPHX1/GSTK1/CBR1/NAT1/GSTA4	-1.47196544829832
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1861	30/9376	0.503815153143471	PLAAT3/PLB1/PLA2G4C	-1.35452045680959
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1861	23/9376	0.438100133168236	FUT9/RXYLT1	-1.34258475756395
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/1861	45/9376	0.559794614603857	ABCC5/ABCC4/ABCG2/ABCB7/ABCA2	-1.47296302734758
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1861	15/9376	0.335876768762314	ST6GALNAC6	-1.28093623607876
NA	NA	hsa04082	Neuroactive ligand signaling	30/1861	199/9376	0.759520331372067	GNG2/GNG11/GNAI2/GNG5/PRKCB/GNG10/OGFRL1/HRH1/SLC1A6/PLCB1/PRKCA/GNGT1/GNB4/GNB2/ADRB1/HRH2/PLCB2/GRIN2C/P2RY13/GABRA3/PRKACB/PRKACA/GRIA4/GNAI3/TAC3/P2RY1/ADRB2/GNG7/ADCY4/PLCB4	-1.70627437857773
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	6/1861	54/9376	0.559794614603857	CENPX/RPA3/RPA2/FANCL/POLK/UBE2T	-1.61432887248591
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	20/1861	143/9376	0.704636577823037	C1QA/C1QC/FCGR3A/C1QB/FCGR2A/CD86/FCGR1A/HLA-DRA/CD28/C1R/HLA-DPA1/C2/SNRPD1/HLA-DQA2/HLA-DMA/HLA-DMB/SNRPD3/SSB/TNF/C9	-1.77111860220147
NA	NA	hsa03272	Virion - Hepatitis viruses	5/1861	48/9376	0.524807451191116	CD81/CD63/CLDN5/CHMP4A/CLDN11	-1.64244299187807
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1861	17/9376	0.296361854790277	ADO	-1.44495207994725
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/1861	18/9376	0.279897307301928	CBR4	-1.52171562267828
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/1861	36/9376	0.419845960952893	GALNT1/GALNT11/GALNT10	-1.73546342264863
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/1861	79/9376	0.573966630163448	HPGDS/GSTO1/MGST2/AKR7A2/ADH5/EPHX1/GSTK1/CBR1/GSTA4	-1.89225682273606
Human Diseases	Substance dependence	hsa05034	Alcoholism	27/1861	191/9376	0.712199431145221	GNG2/HDAC9/CALM2/GNG11/GNAI2/GNG5/GNG10/CALM3/CALM1/GNGT1/GNB4/GNB2/PPP1CA/CREB1/CALML4/BDNF/GRIN2C/HDAC8/PRKACB/PRKACA/GNAI3/PPP1CC/HDAC2/HRAS/GNG7/CREB3L1/KRAS	-1.99969188237185
Organismal Systems	Sensory system	hsa04742	Taste transduction	10/1861	86/9376	0.585831573422641	SCN9A/PLCB1/PLCB2/GABRA3/PRKACB/PRKACA/PDE1C/P2RY1/ADCY4/PLCB4	-1.92005066644042
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	23/1861	168/9376	0.689746935851181	CCND2/IL12RB2/CCND1/PIAS2/SOCS3/IL10RA/PIK3CD/CNTFR/IL2RA/JAK3/PIK3R2/AKT1/IL10RB/HRAS/PIK3R3/IL6R/STAT5A/IRF9/BCL2L1/OSM/PDGFRB/CSHL1/AKT2	-2.01921422576423
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1861	41/9376	0.368645234007418	GRIN2C/GABRA3/GRIA4	-2.0160558672941
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/1861	90/9376	0.503815153143471	ATP1B3/ATP1B1/ABCC4/PRKACB/PRKACA/ABCG2/EPHX1/AQP1/ADCY4	-2.35366551592785
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1861	26/9376	0.193775058901335	HHEX	-2.04847859400064
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/1861	73/9376	0.414094646419291	HPGDS/GSTO1/MGST2/ADH5/GSTK1/GSTA4	-2.5007582958594
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	22/1861	183/9376	0.605679419079583	NOP10/RAN/SNU13/RPP25/NHP2/POP7/IMP3/FBL/RRP7A/XRN1/RPP30/POP5/RPP25L/AK6/NOP56/POP4/EMG1/MPHOSPH10/IMP4/NMD3/RIOK2/DKC1	-2.6806535688633
NA	NA	hsa04519	Cadherin signaling	57/1861	404/9376	0.710828310128165	WNT2/CDH11/VIM/PRICKLE1/ARPC3/YWHAB/PCDH10/ACTB/ARPC5/NCKAP1L/GJA1/PCDH12/ACTG1/BRK1/YWHAH/KRT10/MYO1F/NFKB1/SCN1B/VAV1/TMC8/PPP1CA/MAP2K2/PCDH18/ENAH/ACTR2/MOB1A/PSENEN/RAC2/LRP6/ARPC4/CDH5/ARPC1B/MYO1B/KDR/MYO7A/LEF1/KRT1/GABRA3/FZD2/CYFIP1/PPP1CC/TMC6/HRAS/ABI2/KRT24/DCHS1/MAPK10/PDGFRB/MAPK13/PCDH11X/MOB1B/FZD7/FZD1/FAT4/TCF7/KRAS	-2.95662439103696
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1861	68/9376	0.296361854790277	DHRS4L2/ADH5/PNPLA4/RDH11	-2.89781046505046
NA	NA	hsa04382	Cornified envelope formation	23/1861	217/9376	0.533997627755753	S100A9/S100A6/S100A10/S100A4/SLC27A4/KRT10/S100A11/S100A16/CLDN5/S100A13/KRT1/PPP2CB/FURIN/PPP2R5C/S100A12/KRT24/ABHD5/S100A2/PPP2R3C/CLDN11/CAPN1/PPP2R5B/BLMH	-3.45611589391706
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/1861	66/9376	0.229006887792487	HSD17B2/HSD17B1/HSD17B12	-3.12782148012411
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	38/1861	323/9376	0.592723709580554	ZEB2/MARCKS/CCND2/VIM/CDK6/CCND1/PRKCB/STMN1/FSCN1/PRKCA/PLAU/NFKB1/ZFPM2/TNXB/MAP2K2/PIK3CD/EFNA5/UBE2I/ATM/CDKN2A/PIK3R2/IRS1/HDAC2/TP53/HRAS/NOTCH3/PIK3R3/CDKN1B/NOTCH1/DNMT3A/PDGFRB/CCNG1/RASSF1/CDC25B/FGFR3/SIRT1/KRAS/SPRY2	-3.70670873666088
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	34/1861	370/9376	0.462965275861568	SPX/LPAR6/C3AR1/OGFRL1/KISS1/HRH1/TSPO/NR3C1/FPR1/PTAFR/ADRB1/HRH2/PTGER4/CGA/APLNR/CYSLTR1/GRIN2C/P2RY13/LYPD6/APLN/AGTR1/GABRA3/GRIA4/S1PR1/PTGFR/TAC3/THRA/P2RY1/ADRB2/CYSLTR2/GZMA/S1PR2/NMB/CSHL1	-5.24483210930992
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	16/1861	449/9376	0.179533239427518	PRKG1/CALM2/SLC8A1/ARRB2/CALM3/CALM1/ARRB1/CALML4/CAMK2D/GRK2/RGS2/PRKACB/PRKACA/PDE1C/GNG7/SLC24A4	-8.86595916460677