category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	99/745	238/9376	5.23503468501495	F13A1/CCL2/C1QA/RPS23/CYBB/C1QC/C1QB/RPLP1/RPS18/RPS4X/RPS12/RPS11/RPS27A/RPL30/RPL26/NRP1/RPL32/RPL15/RPL13/RPL23A/RPS2/CFD/RPS19/RPL27A/RPL10/RPL39/RPL21/RPS14/RPL23/RPL28/RPL13A/RPS15/FAU/RPL35/RPL29/UBA52/RPL11/RPS15A/RPS24/RPL41/RPL19/RPL24/RPL18A/RPL37/RPL7A/FCGR2A/RPL37A/RPL18/RPS9/RPL35A/RPL17/RPL9/RPS16/RPL3/RPS3A/RPLP2/RPL10A/RPS7/RPL34/RPL36/RPS6/RPS20/RPL14/RPL27/RPS13/RPS25/RPL12/RPL36A/RPS28/RPS5/RPL8/PRKCB/RPL22/RPL38/C2/JUN/AGTR1/C1R/RPL7/SYK/RPS21/RPS10/PRKCA/RPL5/NLRP3/MMP1/C3AR1/NFKB1/TLR4/RPS3/RPL36AL/RPS27/CASP1/MAPK10/TNFRSF1A/RPS27L/TLR2/TNF/TLR7	19.4425439564912
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	61/745	138/9376	5.56303861492073	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-ND1/MT-CO1/MT-ND2/ATP5F1E/COX6C/MT-ND4/UQCRB/MT-ND5/MT-ND3/COX5B/COX4I2/NDUFA4/COX4I1/UQCR10/COX6B1/NDUFA13/COX7C/NDUFA4L2/ATP5MC2/ATP5MG/COX8A/NDUFA1/UQCR11/COX7B/ATP6V0B/NDUFB2/UQCRH/ATP6V1F/NDUFC2/COX7A2/ATP6V1G1/ATP6V0C/NDUFB11/ATP5ME/NDUFS5/UQCRQ/ATP5PF/NDUFS6/ATP5MF/NDUFA2/NDUFA11/ATP5MC3/ATP5F1D/COX6A1/NDUFB3/NDUFB8/NDUFB7/NDUFB1/ATP6V0D1/NDUFC1/ATP6V0E1/NDUFB5/NDUFV2/NDUFA3/ATP5PD/ATP6V1A/NDUFB10	15.8649213902897
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	74/745	205/9376	4.54296284170895	MT-CO2/MT-ATP6/MT-CYB/CD36/CYBA/CYBB/MT-CO3/MT-ND1/COL3A1/MT-CO1/COL1A1/MT-ND2/COL1A2/RYR2/ATP5F1E/COX6C/MT-ND4/UQCRB/MT-ND5/MT-ND3/COX5B/COX4I2/NDUFA4/COX4I1/UQCR10/MMP2/COX6B1/PRKCB/NDUFA13/COX7C/AGTR1/NCF4/NDUFA4L2/ATP5MC2/COX8A/PLCB1/NDUFA1/PRKCA/UQCR11/COX7B/NDUFB2/UQCRH/NFKB1/NDUFC2/TBC1D4/RAC2/COX7A2/SLC25A5/NDUFB11/NDUFS5/UQCRQ/CTSD/ATP5PF/NDUFS6/NDUFA2/NDUFA11/ATP5MC3/SLC25A6/ATP5F1D/COX6A1/NDUFB3/NDUFB8/NDUFB7/NDUFB1/MAPK10/NDUFC1/PLCB2/NDUFB5/PLCB4/NDUFV2/TGFB3/NDUFA3/ATP5PD/NDUFB10	15.0684436232639
Genetic Information Processing	Translation	hsa03010	Ribosome	74/745	222/9376	4.19507829977629	RPS23/RPLP1/RPS18/RPS4X/RPS12/RPS11/RPS27A/RPL30/RPL26/RPL32/RPL15/RPL13/RPL23A/RPS2/RPS19/RPL27A/RPL10/RPL39/RPL21/RPS14/RPL23/RPL28/RPL13A/RPS15/FAU/RPL35/RPL29/UBA52/RPL11/RPS15A/RPS24/RPL41/RPL19/RPL24/RPL18A/RPL37/RPL7A/RPL37A/RPL18/RPS9/RPL35A/RPL17/RPL9/RPS16/RPL3/RPS3A/RPLP2/RPL10A/RPS7/RPL34/RPL36/RPS6/RPS20/RPL14/RPL27/RPS13/RPS25/RPL12/RACK1/RPL36A/RPS28/RPS5/RPL8/RPL22/RPL38/RPL7/RPS21/RPS10/RPL5/RPS3/RPL36AL/RPS27/MRPS21/RPS27L	14.154213920593
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	80/745	275/9376	3.66115924344112	MT-CO2/MT-ATP6/MT-CYB/C1QA/CYBA/CYBB/MT-CO3/MT-ND1/C1QC/C1QB/MT-CO1/MT-ND2/RYR2/ATP5F1E/COX6C/MT-ND4/EGR1/UQCRB/TUBA1B/MT-ND5/HSPA1A/MT-ND3/COX5B/COX4I2/NDUFA4/COX4I1/UQCR10/ITPR2/COX6B1/NDUFA13/COX7C/NCF4/NDUFA4L2/ATP5MC2/COX8A/NDUFA1/UQCR11/COX7B/NDUFB2/UQCRH/NDUFC2/RAC2/COX7A2/SLC25A5/NDUFB11/PRKACB/NDUFS5/UQCRQ/ATP5PF/NDUFS6/RYR1/NDUFA2/NDUFA11/ATP5MC3/PSMA7/GRIN2C/SLC25A6/ATP5F1D/COX6A1/NDUFB3/NDUFB8/NDUFB7/NDUFB1/CAV1/TUBA1A/MAPK10/CREB1/NCAM2/HSPA8/NDUFC1/PPP3R1/TNF/NDUFB5/PRNP/NDUFV2/NDUFA3/ATP5PD/PSMB1/NDUFB10/BAX	13.1590903702512
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	66/745	227/9376	3.65914318658901	MT-CO2/MT-ATP6/MT-CYB/CYBA/MT-CO3/MT-ND1/HGF/MT-CO1/MT-ND2/ATP5F1E/COX6C/MT-ND4/UQCRB/MT-ND5/MT-ND3/COX5B/COX4I2/NDUFA4/COX4I1/UQCR10/COX6B1/NDUFA13/COX7C/JUN/NDUFA4L2/ATP5MC2/PLD1/COX8A/NDUFA1/PTPRJ/UQCR11/COX7B/NDUFB2/UQCRH/NFKB1/NDUFC2/COX7A2/MGST2/SLC25A5/NDUFB11/NDUFS5/GSTA4/UQCRQ/ATP5PF/NDUFS6/NDUFA2/NDUFA11/ATP5MC3/SLC25A6/HIF1A/ATP5F1D/COX6A1/NDUFB3/NDUFB8/HMOX1/NDUFB7/NDUFB1/MAPK10/SLC26A2/NDUFC1/NDUFB5/NDUFV2/MGST3/NDUFA3/ATP5PD/NDUFB10	11.9151922613899
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	71/745	268/9376	3.33414805168787	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-ND1/MT-CO1/RPS27A/MT-ND2/ATP5F1E/COX6C/MT-ND4/UBA52/UBB/UQCRB/TUBA1B/MT-ND5/GNAI2/MT-ND3/COX5B/COX4I2/NDUFA4/COX4I1/UQCR10/ITPR2/COX6B1/NDUFA13/COX7C/NDUFA4L2/ATP5MC2/COX8A/NDUFA1/UQCR11/COX7B/NDUFB2/CALM2/UQCRH/NDUFC2/COX7A2/SLC25A5/NDUFB11/PRKACB/PRKN/NDUFS5/UQCRQ/ATP5PF/NDUFS6/NDUFA2/NDUFA11/ATP5MC3/CALM3/PSMA7/SLC25A6/ATP5F1D/COX6A1/NDUFB3/NDUFB8/NDUFB7/NDUFB1/TUBA1A/MAPK10/GNAS/NDUFC1/CALML4/NDUFB5/NDUFV2/NDUFA3/ATP5PD/PSMB1/LRRK2/NDUFB10/BAX	11.3898368070277
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	72/745	308/9376	2.94200296347947	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-ND1/MT-CO1/MT-ND2/ATP5F1E/COX6C/MT-ND4/UQCRB/TUBA1B/MT-ND5/MT-ND3/COX5B/COX4I2/NDUFA4/COX4I1/UQCR10/COX6B1/CLTA/NDUFA13/COX7C/NDUFA4L2/CLTC/ATP5MC2/COX8A/PLCB1/NDUFA1/UQCR11/COX7B/NDUFB2/UQCRH/NDUFC2/AP2S1/COX7A2/SLC25A5/NDUFB11/NDUFS5/UQCRQ/POLR2L/ATP5PF/NDUFS6/DCTN4/NDUFA2/NDUFA11/ATP5MC3/PSMA7/SLC25A6/AP2M1/ATP5F1D/COX6A1/SLC1A2/NDUFB3/NDUFB8/NDUFB7/NDUFB1/TUBA1A/MAPK10/CREB1/DNAH8/NDUFC1/GRIA4/PLCB2/NDUFB5/PLCB4/NDUFV2/NDUFA3/ATP5PD/PSMB1/NDUFB10/BAX	10.1812876367466
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	60/745	235/9376	3.21325146365843	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-ND1/MT-CO1/MT-ND2/ATP5F1E/COX6C/MT-ND4/PRKG1/UQCRB/MT-ND5/RPS6/ACTB/MT-ND3/COX5B/COX4I2/NDUFA4/COX4I1/UQCR10/COX6B1/NDUFA13/COX7C/NDUFA4L2/ATP5MC2/ATP5MG/COX8A/NDUFA1/UQCR11/COX7B/NDUFB2/UQCRH/NDUFC2/COX7A2/NDUFB11/PRKACB/ATP5ME/NDUFS5/UQCRQ/ATP5PF/NDUFS6/ATP5MF/NDUFA2/NDUFA11/ATP5MC3/ATP5F1D/COX6A1/NDUFB3/NDUFB8/NDUFB7/NDUFB1/CREB1/GNAS/NDUFC1/NDUFB5/NDUFV2/NDUFA3/ATP5PD/NDUFB10	10.0948774959476
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	93/745	480/9376	2.43838926174497	MT-CO2/MT-ATP6/MT-CYB/CYBB/MT-CO3/MT-ND1/WNT2/MT-CO1/RPS27A/MT-ND2/RYR2/ATP5F1E/COX6C/MT-ND4/UBA52/UBB/UQCRB/TUBA1B/MT-ND5/MT-ND3/COX5B/COX4I2/NDUFA4/COX4I1/UQCR10/ITPR2/COX6B1/PRKCB/NDUFA13/COX7C/NDUFA4L2/ATP5MC2/COX8A/PLCB1/NDUFA1/PRKCA/TNFRSF1B/UQCR11/COX7B/NDUFB2/CALM2/UQCRH/NFKB1/NDUFC2/COX7A2/SLC25A5/TANK/NDUFB11/PRKN/NDUFS5/UQCRQ/LRP6/ATP5PF/NDUFS6/RYR1/DCTN4/NDUFA2/NDUFA11/ATP5MC3/CALM3/PSMA7/GRIN2C/SLC25A6/CSF1/ATP5F1D/COX6A1/NDUFB3/NDUFB8/NDUFB7/NDUFB1/TUBA1A/MAPK10/TNFRSF1A/DNAH8/NDUFC1/GRIA4/PLCB2/CALML4/PPP3R1/C9orf72/TNF/FZD2/NDUFB5/ATXN1/PRNP/PLCB4/NDUFV2/NDUFA3/ATP5PD/PSMB1/LRRK2/NDUFB10/BAX	9.50457889558392
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	46/745	157/9376	3.68739366477151	MT-CO2/MT-CYB/MT-CO3/MT-CO1/COX6C/UQCRB/COX5B/COX4I2/NDUFA4/COX4I1/UQCR10/COX6B1/NDUFA13/COX7C/JUN/NDUFA4L2/COX8A/NDUFA1/UQCR11/COX7B/NDUFB2/UQCRH/NFKB1/NDUFC2/COX7A2/SOCS3/NDUFB11/NDUFS5/UQCRQ/NDUFS6/NDUFA2/NDUFA11/COX6A1/NDUFB3/NDUFB8/NDUFB7/NDUFB1/MAPK10/TNFRSF1A/NDUFC1/TNF/NDUFB5/NDUFV2/NDUFA3/NDUFB10/BAX	9.97636715818035
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	77/745	388/9376	2.4975852764132	MT-CO2/MT-ATP6/MT-CYB/CYBB/MT-CO3/MT-ND1/WNT2/MT-CO1/MT-ND2/ATP5F1E/COX6C/MT-ND4/UQCRB/TUBA1B/MT-ND5/MT-ND3/COX5B/COX4I2/NDUFA4/COX4I1/UQCR10/ITPR2/COX6B1/NDUFA13/COX7C/NDUFA4L2/ATP5MC2/COX8A/PLCB1/NDUFA1/UQCR11/COX7B/NDUFB2/CALM2/UQCRH/APOE/NFKB1/LRP1/NDUFC2/COX7A2/SLC25A5/NDUFB11/NDUFS5/UQCRQ/LRP6/ATP5PF/NDUFS6/NDUFA2/NDUFA11/ATP5MC3/CALM3/PSMA7/GRIN2C/SLC25A6/CSF1/ATP5F1D/COX6A1/NDUFB3/NDUFB8/NDUFB7/NDUFB1/TUBA1A/MAPK10/TNFRSF1A/NDUFC1/PLCB2/CALML4/PPP3R1/TNF/FZD2/NDUFB5/PLCB4/NDUFV2/NDUFA3/ATP5PD/PSMB1/NDUFB10	8.85134174290667
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	43/745	149/9376	3.63198054141705	MT-ND1/GNG2/MT-ND2/GNG11/MT-ND4/GNGT1/MT-ND5/GNAI2/MT-ND3/NDUFA4/ITPR2/GNG10/PRKCB/NDUFA13/NDUFA4L2/PLCB1/NDUFA1/PRKCA/NDUFB2/NDUFC2/GNB4/GNG5/NDUFB11/PRKACB/KCNJ5/NDUFS5/NDUFS6/NDUFA2/NDUFA11/NDUFB3/NDUFB8/NDUFB7/NDUFB1/MAPK10/NDUFC1/GRIA4/PLCB2/NDUFB5/PLCB4/NDUFV2/NDUFA3/GABRA3/NDUFB10	9.51434212987435
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	71/745	368/9376	2.42812955938138	MT-CO2/MT-ATP6/MT-CYB/MT-CO3/MT-ND1/MT-CO1/MT-ND2/ATP5F1E/COX6C/MT-ND4/UQCRB/TUBA1B/MT-ND5/ACTB/MT-ND3/COX5B/COX4I2/NDUFA4/COX4I1/UQCR10/COX6B1/NDUFA13/COX7C/NDUFA4L2/ATP5MC2/COX8A/NDUFA1/TNFRSF1B/UQCR11/COX7B/NDUFB2/UQCRH/PFN1/NDUFC2/COX7A2/TANK/NDUFB11/PRKN/NDUFS5/UQCRQ/ATP5PF/NDUFS6/DCTN4/NDUFA2/NDUFA11/ATP5MC3/PSMA7/GRIN2C/CASP1/CHCHD10/ATP5F1D/COX6A1/SLC1A2/NDUFB3/NDUFB8/NDUFB7/NDUFB1/TUBA1A/TNFRSF1A/DNAH8/NDUFC1/PPP3R1/C9orf72/TNF/NDUFB5/NDUFV2/NDUFA3/ATP5PD/PSMB1/NDUFB10/BAX	8.21127401654071
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	28/745	95/9376	3.70933239138114	CCL2/CCL3/CD86/CD28/ITGB2/CCL3L1/JUN/MMP1/ICAM1/ATP6V0B/ANGPT1/TLR4/ATP6V1F/TNFSF13B/ATP6V1G1/ATP6V0C/TNFRSF11A/CSF1/TEK/ATP6V0D1/TLR2/ATP6V0E1/ITGAL/TNF/TGFB3/LTB/CXCL12/ATP6V1A	7.79758148430545
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	37/745	155/9376	3.0042173630656	CD14/CD36/CYBA/CYBB/FCGR3A/HLA-C/MRC1/FCGR2A/TUBA1B/ACTB/FCGR1A/ITGB2/CTSS/CLEC7A/NCF4/C1R/CORO1A/COLEC12/CD209/HLA-A/MSR1/ATP6V0B/TLR4/ATP6V1F/HLA-E/ATP6V1G1/ITGAM/ATP6V0C/SEC61G/ITGB5/SEC61B/TUBA1A/ATP6V0D1/TLR2/ATP6V0E1/FCGR2B/ATP6V1A	7.39187943224657
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	19/745	50/9376	4.78238926174497	CCL2/CD36/HBB/HGF/CR1/HBA1/HBA2/VCAM1/PECAM1/CD81/GYPC/ITGB2/ICAM1/TLR4/LRP1/TLR2/ITGAL/TNF/TGFB3	7.87837655975551
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	27/745	97/9376	3.50310662146267	GNG2/GNG11/GUCY1A2/RYR2/PRKG1/GNGT1/GNAI2/GNG10/PRKCB/PLCB1/PRKCA/GUCY1A1/CALM2/GNB4/GNG5/PRKACB/KCNJ5/RYR1/GUCY1B1/CALM3/GRIN2C/CREB1/GNAS/GRIA4/PLCB2/CALML4/PLCB4	7.28027601825161
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	24/745	87/9376	3.47178893774589	MT-CO2/MT-CYB/MT-CO3/MT-CO1/RYR2/COX6C/UQCRB/COX5B/COX4I2/COX4I1/UQCR10/ATP1B3/COX6B1/COX7C/ATP1B1/COX8A/UQCR11/COX7B/CACNB4/UQCRH/TPM3/COX7A2/UQCRQ/COX6A1	6.80486862944242
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	22/745	78/9376	3.54968163827224	CD14/C1QA/C1QC/C1QB/LY96/GNAI2/PYCARD/ITGB2/C2/JUN/C1R/NLRP3/CFL1/CALM2/NFKB1/TLR4/ITGAM/CALM3/CASP1/MAPK10/CALML4/TNF	6.64311396613003
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	45/745	250/9376	2.26534228187919	LGMN/CTSC/NPC2/CD68/LAPTM5/CD63/CTSZ/CLTA/AP1S2/CTSS/CLTC/ATP6V0B/LAMTOR4/CTSB/BLOC1S1/ASAH1/ATP6V1F/AP2S1/MANBA/ATP6V1G1/LAMTOR2/ATP6V0C/AP1B1/SUMF1/CTSD/MAN2B1/DMXL2/FUCA1/CTBS/AP2M1/VAMP8/ARSB/NEU1/LAMTOR1/MCOLN2/ATP6V0D1/HYAL2/ATP6V0E1/SLC15A3/MCOLN1/DMXL1/GLA/CTSO/ATP6V1A/TLR7	5.9575954448967
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	31/745	142/9376	2.74748085830419	CCL2/MEF2C/CYBA/VCAM1/PECAM1/ACTB/KLF2/MMP2/JUN/BMP4/MEF2A/ICAM1/CALM2/NFKB1/KDR/RAC2/CDH5/MGST2/SUMO2/GSTA4/CALM3/ACVR2A/HMOX1/CAV1/MAPK10/TNFRSF1A/CALML4/TNF/SUMO1/MGST3/MAP2K5	6.16445775325841
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	38/745	196/9376	2.43999452129845	GNG2/RPS27A/GNG11/HLA-C/UBA52/UBB/GNGT1/CD86/LYN/ITPR2/GNG10/JUN/HCK/RB1/CD200R1/SYK/HLA-A/CDK6/ICAM1/CALM2/NFKB1/CCR1/HLA-E/GNB4/GNG5/PREX1/CALM3/NFATC2/HIF1A/PIK3CG/MAPK10/TNFRSF1A/CREB1/CALML4/PPP3R1/LEF1/BAX/PIK3R5	5.98550435460115
NA	NA	hsa04517	IgSF CAM signaling	50/745	299/9376	2.10455433099145	NRP1/MTSS1/CADM3/MAGI1/PTPRD/TUBA1B/CD86/LYN/ACTB/ROBO2/SLIT3/CD28/EPB41L2/SLIT2/PRKCB/ANK2/ITGB2/ARPC3/LCP2/UNC5C/ROBO1/CD209/MYL6/PRKCA/IL1RAPL1/DOK2/ARPC1B/PMP22/ICAM1/NRP2/INPP5D/KDR/VAV1/DYNLL1/ITGAM/LMO7/MYL12A/ACTR2/MSN/TUBA1A/EPB41L3/MAPK10/ICAM2/NCAM2/RAPGEF6/JAM3/ITGAL/ITGA4/KIRREL1/ARPC4	5.70275515266179
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	25/745	103/9376	3.05466866488565	CD14/LAMA2/COL3A1/COL1A1/COL1A2/PRKCB/ITGB2/LAMA4/PLCB1/PRKCA/NFKB1/GNA14/TLR4/ITGAM/PRKACB/SERPINB9/GNA15/SERPINB6/GNAS/TLR2/PLCB2/TNF/LAMC3/PLCB4/TGFB3	6.16003949179359
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	37/745	193/9376	2.41271342629621	CXCL14/CCL2/CCL3/CCL4/CCL4L2/GNG2/GNG11/GNGT1/LYN/GNAI2/GNG10/PRKCB/CCL3L1/DOCK2/HCK/PLCB1/ELMO1/ARRB2/CCL8/NFKB1/GRK3/CCR1/RAC2/VAV1/GNB4/GNG5/WAS/PREX1/PRKACB/CCL13/JAK3/PIK3CG/CX3CR1/PLCB2/PLCB4/CXCL12/PIK3R5	5.82604253866378
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	14/745	37/9376	4.76198077271903	HBB/HBA1/HBA2/VCAM1/IDO2/PRKCB/LAMA4/PLCB1/PRKCA/ICAM1/PLCB2/TNF/PLCB4/IDO1	6.73597493048873
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	41/745	227/9376	2.27310410075984	CCL2/CCL3/B2M/CCL4/CCL4L2/GNG2/GNG11/HLA-C/GNGT1/GNAI2/ITPR2/GNG10/PRKCB/CCL3L1/RB1/PLCB1/PRKCA/HLA-A/CDK6/CALM2/NFKB1/CCR1/RAC2/HLA-E/GNB4/GNG5/PRKACB/IL10RA/CALM3/NFATC2/PTGER4/TNFRSF1A/CREB1/GNAS/PLCB2/CALML4/PPP3R1/TNF/PLCB4/CXCL12/BAX	5.70457439291777
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	39/745	212/9376	2.31520830695201	HGF/MAGI1/IGF1/FYB1/DOCK4/ACTB/GNAI2/PRKCB/ITGB2/LCP2/CSF1R/KITLG/PLCB1/PRKCA/PDGFC/FGF7/CALM2/ANGPT1/PFN1/KDR/P2RY1/RAC2/VAV1/ITGAM/EVL/SIPA1L2/CALM3/MAGI3/CSF1/TEK/RAPGEF5/GNAS/RAPGEF6/PLCB2/CALML4/ITGAL/PLCB4/ID1/FPR1	5.69053566658233
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	35/745	181/9376	2.43360895843376	CD14/FCER1G/FCGR3A/CR1/MRC1/FCGR2A/FCGR1A/ITGB2/CTSS/CLEC7A/SYK/CORO1A/CD209/ATP6V0B/CALM2/NFKB1/TLR4/TLR1/ITGAM/ATP6V0C/CTSD/LSP1/IL10RA/CALM3/MAPK10/TNFRSF1A/CREB1/ATP6V0D1/TLR2/CALML4/PPP3R1/TNF/TGFB3/FCGR2B/BAX	5.72172977412514
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	39/745	216/9376	2.27233407904549	CD14/CCL2/CD36/CCL3/CYBA/CYBB/VCAM1/LY96/LYN/HSPA1A/PYCARD/CCL3L1/JUN/NCF4/PLCB1/PRKCA/NLRP3/MMP1/ICAM1/CALM2/NFKB1/TLR4/VAV1/POU2F2/TANK/CALM3/NFATC2/CASP1/TNFRSF10B/MAPK10/TNFRSF1A/TLR2/HSPA8/PLCB2/CALML4/PPP3R1/TNF/PLCB4/BAX	5.55793565751767
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	26/745	116/9376	2.82082851191854	CYBA/CYBB/VCAM1/PECAM1/ACTB/GNAI2/MMP2/PRKCB/ITGB2/NCF4/THY1/PRKCA/ICAM1/RAC2/VAV1/CDH5/ITGAM/TXK/MYL12A/MSN/CLDN5/JAM3/ITGAL/ARHGAP5/ITGA4/CXCL12	5.79729983849663
Organismal Systems	Immune system	hsa04611	Platelet activation	27/745	126/9376	2.69683604985618	FCER1G/COL3A1/COL1A1/COL1A2/GUCY1A2/PRKG1/FCGR2A/LYN/ACTB/GNAI2/ITPR2/TBXAS1/LCP2/SYK/PLCB1/GUCY1A1/P2RY1/FERMT3/PRKACB/MYL12A/GUCY1B1/VAMP8/PIK3CG/GNAS/PLCB2/PLCB4/PIK3R5	5.63361941981651
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	23/745	98/9376	2.95367757841392	FCGR3A/MARCKS/PTPRC/FCGR2A/LYN/FCGR1A/PRKCB/ARPC3/HCK/BIN1/SYK/PLD1/PRKCA/ARPC1B/PLPP3/CFL1/INPP5D/RAC2/VAV1/WAS/ACTR2/FCGR2B/ARPC4	5.71178645640277
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	16/745	53/9376	3.79931619602381	ATP1B3/CLTA/PRKCB/ATP1B1/ATP2B1/CLTC/PLCB1/PRKCA/AP2S1/PRKACB/KL/AP2M1/GNAS/RAB11A/PLCB2/PLCB4	6.00406334857193
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	28/745	138/9376	2.55352592160296	CCL2/FCGR2A/FYB1/ACTB/PYCARD/CD4/ARPC3/JUN/LCP2/ELMO1/ARPC1B/NLRP3/NFKB1/TLR4/SKAP2/RAC2/VAV1/WAS/ACTR2/WIPF1/NFATC2/CASP1/GIT2/MAPK10/TNF/PKN2/ITGA4/ARPC4	5.40134956198182
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	28/745	140/9376	2.51704697986577	SPP1/MEF2C/GNG2/GNG11/RYR2/EGR1/GNGT1/RPS6/GNAI2/KLF2/ITPR2/GNG10/AGTR1/PLCB1/MEF2A/CALM2/GNB4/GNG5/PRKACB/RYR1/CALM3/PIK3CG/PLCB2/CALML4/APLNR/PLCB4/APLN/PIK3R5	5.31317722292728
Organismal Systems	Endocrine system	hsa04924	Renin secretion	18/745	69/9376	3.28310475634666	GUCY1A2/GNAI2/ITPR2/AGTR1/PLCB1/GUCY1A1/CTSB/CALM2/PRKACB/GUCY1B1/CALM3/PTGER4/CREB1/GNAS/PLCB2/CALML4/PPP3R1/PLCB4	5.5921491163535
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	37/745	214/9376	2.17595182838863	B2M/GNG2/GNG11/HLA-C/GNGT1/GNAI2/BST2/ITPR2/GNG10/CD4/PRKCB/AP1S2/JUN/ELOB/PRKCA/TNFRSF1B/HLA-A/CFL1/CALM2/NFKB1/TLR4/RAC2/HLA-E/GNB4/GNG5/AP1B1/CALM3/NFATC2/APOBEC3C/MAPK10/TNFRSF1A/TLR2/CALML4/PPP3R1/TNF/BAX/RBX1	5.11251377207522
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	29/745	154/9376	2.3699468316918	MEF2C/GUCY1A2/RYR2/ACTB/GNAI2/ITPR2/PRKCB/JUN/MYL6/PLCB1/PRKCA/GUCY1A1/CACNB4/CALM2/TRPM2/PRKACB/KCNJ5/RYR1/GUCY1B1/CALM3/NFATC2/PIK3CG/GNAS/PLCB2/CALML4/PPP3R1/PLCB4/MAP2K5/PIK3R5	5.03598850405139
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	27/745	142/9376	2.39296719916816	CYBA/TYROBP/FCGR3A/FCGR2A/FCGR1A/ITPR2/JUN/LCP2/NCF4/CSF1R/LILRB5/SYK/SPI1/JUNB/NFKB1/SOCS3/TNFRSF11A/NFATC2/CSF1/SIRPA/TEC1/MAPK10/TNFRSF1A/CREB1/PPP3R1/TNF/FCGR2B	4.91386638665663
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	14/745	51/9376	3.45477036452165	ACTB/PRKCA/ATP6V0B/KCNQ1/ATP6V1F/ATP6V1G1/ATP6V0C/PRKACB/SEC61G/SEC61B/GNAS/ATP6V0D1/ATP6V0E1/ATP6V1A	5.1642202421676
Organismal Systems	Digestive system	hsa04970	Salivary secretion	20/745	93/9376	2.70650212888793	CST3/GUCY1A2/PRKG1/ITPR2/ATP1B3/LYZ/PRKCB/ATP1B1/ATP2B1/PLCB1/PRKCA/GUCY1A1/CALM2/PRKACB/GUCY1B1/CALM3/GNAS/PLCB2/CALML4/PLCB4	4.85889316067162
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	23/745	116/9376	2.49534829900486	GNG2/GNG11/GNGT1/GNAI2/ITPR2/GNG10/PRKCB/PLD1/PLCB1/PRKCA/GRK3/GNB4/GNG5/PRKACB/GRIN2C/SLC1A2/GNAS/DLGAP1/GRIA4/PLCB2/PPP3R1/PLCB4/TRPC1	4.7610098345741
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	21/745	101/9376	2.61673200877135	CCL2/CYBB/COL3A1/COL1A1/COL1A2/VCAM1/EGR1/MMP2/PRKCB/JUN/AGTR1/PLCB1/PRKCA/ICAM1/NFKB1/MAPK10/PLCB2/TNF/PLCB4/TGFB3/BAX	4.79926776079847
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	21/745	103/9376	2.56592167850394	CCL2/C1QA/CCL3/C1QC/C1QB/GNAI2/CCL3L1/JUN/PLCB1/NFKB1/GNA14/TLR4/GNA15/MAPK10/TNFRSF1A/GNAS/TLR2/PLCB2/TNF/PLCB4/TGFB3	4.69474205038157
Organismal Systems	Nervous system	hsa04730	Long-term depression	15/745	60/9376	3.14630872483221	GUCY1A2/IGF1/PRKG1/LYN/GNAI2/ITPR2/PRKCB/PLCB1/PRKCA/GUCY1A1/RYR1/GUCY1B1/GNAS/PLCB2/PLCB4	4.89988957212976
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	38/745	250/9376	1.91295570469799	DAB2/FOLR2/HLA-C/WWP1/PSD3/HSPA1A/CLTA/ARPC3/CYTH4/BIN1/CLTC/PLD1/SNX6/HLA-A/ARPC1B/ARRB2/EPS15/GRK3/AP2S1/HLA-E/SNX3/SNX2/CAPZA2/ARAP1/ACTR2/WIPF1/AP2M1/GIT2/CAV1/ACAP2/RAB11A/HSPA8/IL2RA/ARAP2/CAPZB/ZFYVE16/ARPC4/VPS45	4.29845807382927
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	17/745	76/9376	2.81511833274461	ACTB/GNAI2/ITPR2/ATP1B3/PRKCB/ATP1B1/PLCB1/PRKCA/CALM2/KCNQ1/HRH2/PRKACB/CALM3/GNAS/PLCB2/CALML4/PLCB4	4.66770586618656
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	24/745	130/9376	2.32342798141456	COL3A1/GNG2/COL1A1/GNG11/COL1A2/GNGT1/GNAI2/MMP2/GNG10/JUN/PLCB1/PRKCA/MMP1/ARRB2/NFKB1/GNB4/GNG5/PRKACB/GNA15/MAPK10/CREB1/GNAS/PLCB2/PLCB4	4.46404188290352
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	17/745	78/9376	2.74293581139219	CYBA/CYBB/FCGR3A/CR1/FCGR2A/FCGR1A/PRKCB/ITGB2/JUN/NCF4/NFKB1/TLR4/ITGAM/TLR2/TNF/TGFB3/ITGA4	4.54116351505502
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	49/745	362/9376	1.70352627090363	SPP1/LAMA2/HGF/GNG2/COL1A1/GNG11/CSH1/COL1A2/AREG/COL6A1/MAGI1/IGF1/GNGT1/CCND2/COL6A2/RPS6/GNG10/LPAR6/LAMA4/CSF1R/SYK/KITLG/PRKCA/CDK6/PDGFC/FGF7/ANGPT1/NFKB1/TLR4/KDR/GNB4/GNG5/PIK3AP1/JAK3/TNXB/ITGB5/YWHAB/CSF1/CSHL1/TEK/PIK3CG/CREB1/TLR2/IL2RA/LAMC3/SGK3/PKN2/ITGA4/PIK3R5	4.01059717953737
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	31/745	195/9376	2.00072965066254	CYBA/CYBB/FCGR3A/CR1/HDAC9/FCGR2A/ACTB/FCGR1A/PRKCB/ITGB2/CLEC7A/NCF4/SYK/PLCB1/ATG7/PRKCA/CLCN5/NFKB1/TLR4/RAC2/HDAC8/ITGAM/SLC25A5/SLC25A6/CASP1/TLR2/PLCB2/ITGAL/PLCB4/FPR1/TLR7	4.14879805630394
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	34/745	224/9376	1.91025886864813	B2M/NRP1/HLA-C/EGR1/CCND2/CD4/ITGB2/JUN/RB1/SPI1/HLA-A/ICAM1/NFKB1/TSPO/HLA-E/SLC25A5/PRKACB/JAK3/NFATC2/SLC25A6/MAP3K1/CDKN2C/MAPK10/TNFRSF1A/CREB1/EGR2/PPP3R1/IL2RA/ITGAL/TNF/TGFB3/RANBP1/CDC27/BAX	4.05101768068026
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	18/745	89/9376	2.54532840660584	GUCY1A2/PRKG1/TUBA1B/GNAI2/ITPR2/PRKCB/PLCB1/PRKCA/GUCY1A1/PDGFC/GJA1/PRKACB/GUCY1B1/TUBA1A/GNAS/PLCB2/PLCB4/MAP2K5	4.3033957319411
NA	NA	hsa04518	Integrin signaling	26/745	154/9376	2.12477991806851	SPP1/LAMA2/HGF/COL1A1/COL1A2/COL6A1/VCAM1/IGF1/CCND2/COL6A2/ACTB/FREM1/ITGB2/LAMA4/ICAM1/PDGFC/KDR/FERMT3/RAC2/ITGAM/TNXB/ITGB5/ICAM2/ITGAL/LAMC3/ITGA4	4.13474348488819
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	21/745	115/9376	2.29817332944266	MEF2C/EGR1/PDE4D/GNAI2/NACA/ITPR2/NR4A2/PDE4B/PRKCB/PLD1/PLCB1/PRKCA/MEF2A/ARRB2/PRKACB/LRP6/KL/CREB1/GNAS/PLCB2/PLCB4	4.11515195787843
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	19/745	100/9376	2.39119463087248	CXCL14/CCL2/CCL3/CCL4/CCL4L2/CCL3L1/CSF1R/TNFRSF1B/CCL8/CCR1/CCL13/IL10RA/CSF1/CX3CR1/TNFRSF10B/TNFRSF1A/IL2RA/TNF/CXCL12	4.10904350264454
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	23/745	133/9376	2.1763940051471	GNG2/GNG11/GNGT1/GNAI2/ITPR2/GNG10/PRKCB/PLCB1/PRKCA/ARRB2/CALM2/GNB4/GNG5/PRKACB/KCNJ5/CALM3/MAPK10/CREB1/GNAS/GRIA4/PLCB2/CALML4/PLCB4	4.01425875221492
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/745	70/9376	2.69683604985618	LAMA2/HLA-C/CD86/ACTB/CD28/ITGB2/DTNA/HLA-A/ICAM1/EIF4G3/RAC2/HLA-E/CAV1/ITGAL/SGCA	4.18639877371259
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	18/745	93/9376	2.43585191599913	CGA/EGR1/ITPR2/MMP2/PRKCB/JUN/PLD1/PLCB1/PRKCA/CALM2/PRKACB/CALM3/MAP3K1/MAPK10/GNAS/PLCB2/CALML4/PLCB4	4.08827562314961
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	13/745	56/9376	2.9215723873442	CD14/CR1/HSPA1A/PYCARD/ITGB2/NFKB1/TLR4/ITGAM/EEF1G/CASP1/TLR2/HSPA8/TNF	4.23717130963571
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	19/745	105/9376	2.27732821987856	CD14/CCL4/CCL4L2/VCAM1/LY96/EDA/LYN/PRKCB/SYK/ICAM1/NFKB1/TLR4/TNFSF13B/TNFRSF11A/CCL13/TNFRSF1A/TNF/LTB/CXCL12	3.86693687311405
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	19/745	105/9376	2.27732821987856	FCER1G/PYCARD/ITPR2/JUN/CLEC7A/SYK/CD209/NLRP3/CALM2/NFKB1/LSP1/CALM3/NFATC2/CASP1/MAPK10/EGR2/CALML4/PPP3R1/TNF	3.86693687311405
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	18/745	98/9376	2.31157375701959	ITPR2/ATP1B3/NR4A2/PRKCB/ATP1B1/ATP2B1/AGTR1/PLCB1/PRKCA/CALM2/PRKACB/KCNJ5/CALM3/CREB1/GNAS/PLCB2/CALML4/PLCB4	3.83452689670506
Human Diseases	Substance dependence	hsa05032	Morphine addiction	17/745	91/9376	2.35108783833616	GNG2/GNG11/GNGT1/PDE4D/GNAI2/GNG10/PDE4B/PRKCB/PRKCA/ARRB2/GRK3/GNB4/GNG5/PRKACB/KCNJ5/GNAS/GABRA3	3.80492887641913
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	28/745	187/9376	1.88442019882999	CCL2/CYBA/CYBB/IFI16/PYCARD/ITPR2/JUN/NAMPT/GABARAP/PLCB1/NLRP3/GPSM3/CTSB/NFKB1/TLR4/TRPM2/TANK/ANTXR1/CASP1/GABARAPL2/CARD8/CARD16/MAPK10/PLCB2/TNF/PLCB4/PKN2/NLRP1	3.58904204815123
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	25/745	160/9376	1.96644295302013	HLA-C/VCAM1/CADM3/PTPRC/VCAN/PTPRD/PECAM1/CD86/CD28/CD4/ITGB2/HLA-A/SIGLEC1/ICAM1/HLA-E/CDH5/ITGAM/CD34/LRRC4/CLDN5/ICAM2/NCAM2/JAM3/ITGAL/ITGA4	3.62241495580551
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	25/745	166/9376	1.89536670170615	MEF2C/GUCY1A2/PRKG1/GNAI2/ITPR2/ATP1B3/ATP1B1/ATP2B1/AGTR1/PLCB1/MEF2A/GUCY1A1/CALM2/SLC25A5/GUCY1B1/CALM3/NFATC2/SLC25A6/PIK3CG/CREB1/PLCB2/CALML4/PPP3R1/PLCB4/PIK3R5	3.41946674365337
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	29/745	204/9376	1.78907751019871	LUM/DCN/WNT2/HGF/COL1A1/COL1A2/IGF1/RPS6/CD63/ACTB/ITPR2/MMP2/PRKCB/ANK2/GPC3/PRKCA/TWIST1/TLR4/KDR/VAV1/PRKACB/MSN/ITGB5/HIF1A/CAV1/TLR2/TNF/FZD2/PLAUR	3.34761837108563
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	21/745	133/9376	1.98714235252561	TYROBP/HCST/FCER1G/FCGR3A/HLA-C/PRKCB/ITGB2/LCP2/SYK/PRKCA/HLA-A/ICAM1/RAC2/VAV1/HLA-E/NFATC2/TNFRSF10B/ICAM2/PPP3R1/ITGAL/TNF	3.36846737655082
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	17/745	99/9376	2.161100942309	C1QA/FCGR3A/C1QC/C1QB/CFD/FCGR2A/FCGR1A/ITGB2/C2/C1R/ICAM1/C3AR1/ITGAM/PTAFR/ITGAL/FCGR2B/FPR1	3.41206277566829
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	28/745	200/9376	1.76193288590604	FCGR2A/TUBA1B/ACTB/PYCARD/ARPC3/CYTH4/JUN/NCKAP1L/ARPC1B/NLRP3/NFKB1/TLR4/RPS3/MYO5A/MYO1F/MYO1B/ACTR2/BRK1/WIPF1/CASP1/CLDN5/TNFRSF10B/TUBA1A/MAPK10/TNFRSF1A/TNF/BAX/ARPC4	3.19991343845005
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	33/745	248/9376	1.6746481922494	CD14/LY96/PTPRC/TUBA1B/ACTB/PYCARD/ARPC3/CYTH4/JUN/NCKAP1L/ELMO1/ARPC1B/NLRP3/NFKB1/PFN1/TLR4/RPS3/DYNLL1/MYL12A/ACTR2/DCTN4/BRK1/CASP1/PIK3CG/TNFRSF10B/TUBA1A/MAPK10/TNFRSF1A/TLR2/LEF1/TNF/BAX/ARPC4	3.1633598776381
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	23/745	154/9376	1.87961300444522	RYR2/GNAI2/ATP1B3/CREM/ATP1B1/ATP2B1/AGTR1/PLCB1/PRKCA/SCN1B/CACNB4/CALM2/KCNQ1/TPM3/PRKACB/CALM3/PIK3CG/CREB1/GNAS/PLCB2/CALML4/PLCB4/PIK3R5	3.23349846572498
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	25/745	178/9376	1.76758917125405	WNT2/PRICKLE1/SERPINF1/CCND2/RSPO2/PRKCB/RSPO3/JUN/PLCB1/PRKCA/RAC2/FRZB/PRKACB/LRP6/NFATC2/NLK/BAMBI/INVS/MAPK10/PLCB2/PPP3R1/LEF1/FZD2/PLCB4/RBX1	3.03756341972375
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	15/745	88/9376	2.14521049420378	F13A1/C1QA/C1QC/C1QB/CR1/CFD/A2M/ITGB2/C2/VSIG4/C1R/PROS1/C3AR1/ITGAM/PLAUR	3.17101844365498
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	18/745	115/9376	1.969862853808	GNG2/GNG11/GNGT1/GNAI2/ITPR2/GNG10/PRKCB/PLCB1/PRKCA/KCNQ1/GNB4/GNG5/PRKACB/PIK3CG/CREB1/PLCB2/PLCB4/PIK3R5	3.07442229107806
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	12/745	65/9376	2.32342798141456	SPP1/KISS1/CGA/ITPR2/PRKCB/PLCB1/PRKCA/ARRB2/KCNJ5/PLCB2/PLCB4/TRPC1	3.14551705314724
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	37/745	300/9376	1.55217897091723	CD14/MEF2C/HGF/AREG/IGF1/HSPA1A/MKNK1/PRKCB/JUN/DUSP6/CSF1R/KITLG/PRKCA/ARRB2/PDGFC/CACNB4/FGF7/ANGPT1/NFKB1/KDR/RAC2/PRKACB/MAP3K8/NLK/CSF1/TEK/DUSP9/MECOM/MAP3K1/MAPK10/TNFRSF1A/HSPA8/PPP3R1/TNF/STMN1/TGFB3/MAP2K5	2.85579127921605
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	27/745	201/9376	1.69055394170089	CD14/MEF2C/MAF/IGF1/NR4A3/RUNX1T1/BMP2K/CCND2/CD86/FCGR1A/RUNX1/FLI1/DUSP6/CSF1R/SPI1/NFKB1/LMO2/ITGAM/PROM1/ETV5/TSPAN7/NUPR1/LYL1/CDKN2C/REL/HHEX/BAX	2.90754079612326
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/745	42/9376	2.69683604985618	FTL/CYBB/SLC40A1/ATG7/GPX4/NCOA4/SAT2/HMOX1/PRNP	3.23790308475289
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	17/745	109/9376	1.96283480081276	SPP1/CD14/CCL3/CCL4/CCL4L2/LY96/CD86/CCL3L1/JUN/NFKB1/TLR4/TLR1/MAP3K8/MAPK10/TLR2/TNF/TLR7	2.9704938858346
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	16/745	101/9376	1.9937005781115	WNT2/GNAI2/PRKCB/KITLG/PLCB1/PRKCA/CALM2/PRKACB/CALM3/CREB1/GNAS/PLCB2/CALML4/LEF1/FZD2/PLCB4	2.94979942411211
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	12/745	67/9376	2.25407192226786	ITPR2/PRKCB/PLCB1/PRKCA/CALM2/PRKACB/CALM3/GRIN2C/PLCB2/CALML4/PPP3R1/PLCB4	3.02650605341013
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	32/745	254/9376	1.58554140463986	HGF/RYR2/ITPR2/PRKCB/ATP2B1/AGTR1/HRH1/PLCB1/PRKCA/PDGFC/FGF7/CALM2/GNA14/KDR/HRH2/SLC25A5/PRKACB/PTAFR/RYR1/CALM3/NFATC2/GRIN2C/SLC25A6/GNA15/MCOLN2/GNAS/PLCB2/CALML4/PPP3R1/PLCB4/MCOLN1/PTGFR	2.77947422369567
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/745	103/9376	1.95498794552681	COL3A1/COL14A1/COL15A1/COL1A1/COL1A2/COL6A1/SLC16A10/COL6A2/ATP1B3/ATP1B1/ELN/COL5A2/KCNQ1/COL21A1/PRCP/SLC7A7	2.86312024861654
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	17/745	112/9376	1.91025886864813	LAMA2/LY96/HSPA1A/GNAI2/LAMA4/NFKB1/TLR4/IL10RA/PIK3CG/MAPK10/TNFRSF1A/TLR2/HSPA8/TNF/LAMC3/TGFB3/PIK3R5	2.84713377530538
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/745	69/9376	2.18873650423111	PRKCB/JUN/PRKCA/CALM2/PRKACB/CALM3/GRIN2C/CREB1/GNAS/GRIA4/CALML4/PPP3R1	2.91164554461809
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	30/745	238/9376	1.58637414697423	HGF/GNG2/GNG11/IGF1/GNGT1/RGL1/GNG10/PRKCB/CSF1R/PLD1/KITLG/PRKCA/PDGFC/FGF7/CALM2/ANGPT1/NFKB1/KDR/RAC2/GNB4/GNG5/PRKACB/RALGAPA2/CALM3/CSF1/TEK/RAPGEF5/MAPK10/REL/CALML4	2.69197444069013
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	13/745	79/9376	2.07098802140855	SYT1/CLTA/CLTC/ATP6V0B/ATP6V1F/AP2S1/ATP6V1G1/ATP6V0C/AP2M1/SLC1A2/ATP6V0D1/ATP6V0E1/ATP6V1A	2.8084064375748
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	17/745	115/9376	1.86042602859644	GNG2/GNG11/GNGT1/GNAI2/ITPR2/GNG10/PRKCB/PLCB1/PRKCA/GNB4/GNG5/PRKACB/KCNJ5/GNAS/PLCB2/PLCB4/TRPC1	2.7275124021446
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	19/745	134/9376	1.78447360512872	GUCY1A2/PRKG1/ITPR2/PRKCB/AGTR1/MYL6/PLCB1/PRKCA/GUCY1A1/PPP1R14A/CALM2/RAMP2/PRKACB/GUCY1B1/CALM3/GNAS/PLCB2/CALML4/PLCB4	2.68708230482581
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/745	71/9376	2.12708195481614	LYN/JUN/ATP6V0B/NFKB1/ATP6V1F/ATP6V1G1/ATP6V0C/MAPK10/ATP6V0D1/JAM3/ATP6V0E1/ATP6V1A	2.80065554877812
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	14/745	89/9376	1.97969987180454	GNG2/GNG11/GNGT1/GNAI2/GNG10/PRKCB/GABARAP/PRKCA/GNB4/GNG5/PRKACB/GABARAPL2/SLC12A5/GABRA3	2.72824613129775
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	26/745	203/9376	1.61190200681059	SPP1/LAMA2/HGF/COL1A1/COL1A2/COL6A1/IGF1/CCND2/COL6A2/ACTB/PRKCB/JUN/LAMA4/PRKCA/PDGFC/KDR/RAC2/VAV1/MYL12A/TNXB/ITGB5/CAV1/MAPK10/LAMC3/ARHGAP5/ITGA4	2.58944932269302
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	24/745	184/9376	1.64155237817333	EPHA3/NRP1/GNAI2/ROBO2/SLIT3/SLIT2/UNC5C/ROBO1/PRKCA/CFL1/RAC2/FES/EPHA7/MYL12A/NFATC2/EFNB2/LRRC4/SEMA3D/PPP3R1/ABLIM3/SEMA3G/TRPC1/EPHA5/CXCL12	2.58207729690347
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	15/745	99/9376	1.90685377262558	IGF1/ITPR2/PRKCB/HRH1/PLCB1/PRKCA/CALM2/PRKACB/CALM3/PTGER4/MAPK10/GNAS/PLCB2/CALML4/PLCB4	2.66492075563802
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/745	100/9376	1.88778523489933	CD14/CD36/CR1/FCGR1A/CD4/CSF1R/KITLG/ITGAM/CD34/CD37/CSF1/CD33/IL2RA/TNF/ITGA4	2.62216951550413
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	14/745	91/9376	1.93618998451213	LYN/CD81/PRKCB/JUN/LILRB5/SYK/INPP5D/NFKB1/RAC2/VAV1/PIK3AP1/NFATC2/PPP3R1/FCGR2B	2.63649498190384
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	35/745	298/9376	1.47813161569299	CXCL14/CCL2/BMP5/CCL3/CCL4/CCL4L2/CSH1/EDA/IL12RB2/CD4/CCL3L1/GDF15/CSF1R/BMP4/TNFRSF1B/CCL8/CCR1/TNFSF13B/TNFRSF11A/CCL13/TNFRSF25/TNFSF12/IL10RA/CSF1/CSHL1/ACVR2A/CX3CR1/IL33/TNFRSF10B/TNFRSF1A/IL2RA/TNF/TGFB3/LTB/CXCL12	2.46430081564275
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	21/745	157/9376	1.68337536870004	C1QA/CD36/C1QC/C1QB/PECAM1/GAS6/STAB1/PROS1/ELMO1/LRP1/ATP8A1/NFATC2/ITGB5/HIF1A/CASP1/HAVCR2/SIRPA/PTGER4/CX3CR1/CREB1/ADAM9	2.53688310513603
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	16/745	110/9376	1.83057962172056	BMP5/DCN/PITX2/BMP4/FMOD/SMAD6/ACVR2A/BAMBI/SMAD5/SMAD9/TNF/TGFB3/ID1/GREM2/ZFYVE16/RBX1	2.57433275409169
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	15/745	102/9376	1.8507698381366	RYR2/ITPR2/ATP1B3/PRKCB/ATP1B1/ATP2B1/PLCB1/PRKCA/KCNQ1/GNAS/RAB11A/PLCB2/PLCB4/TRPC1/CCK	2.53811818703046
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	12/745	75/9376	2.01363758389262	CGA/ITPR2/ATP1B3/PRKCB/ATP1B1/PLCB1/PRKCA/PRKACB/CREB1/GNAS/PLCB2/PLCB4	2.58929618125625
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	17/745	122/9376	1.7536802728573	CSH1/IGF1/GNAI2/ITPR2/PRKCB/PLCB1/PRKCA/JUNB/SOCS3/PRKACB/CSHL1/MAP3K1/MAPK10/CREB1/GNAS/PLCB2/PLCB4	2.46170230350981
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	11/745	69/9376	2.00634179554518	FCER1G/LYN/LCP2/SYK/PRKCA/INPP5D/RAC2/VAV1/ALOX5AP/MAPK10/TNF	2.46489494932886
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	17/745	125/9376	1.71159194630873	FCER1G/GNAI2/PRKCB/PLD1/PLCB1/PRKCA/NFKB1/ASAH1/RAC2/CTSD/SGMS1/MAPK10/TNFRSF1A/PLCB2/TNF/PLCB4/BAX	2.3530161417356
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	6/745	28/9376	2.69683604985618	ATP6V1F/ATP6V1G1/ATP6V0C/ATP6V0D1/ATP6V0E1/ATP6V1A	2.64175636464639
Human Diseases	Infectious disease: viral	hsa05162	Measles	18/745	136/9376	1.66569285432294	CCND2/HSPA1A/RACK1/CD28/JUN/CD209/CDK6/NFKB1/TLR4/JAK3/MSN/MAPK10/TLR2/HSPA8/IL2RA/FCGR2B/BAX/TLR7	2.29742096572501
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	13/745	89/9376	1.83829273810422	SPP1/CD36/LAMA2/COL1A1/COL1A2/COL6A1/COL6A2/FREM1/LAMA4/TNXB/ITGB5/LAMC3/ITGA4	2.33445873113692
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	18/745	137/9376	1.65353451232058	CTSC/TUBA1B/ACTB/CTSZ/ITPR2/CTSS/JUN/CTSB/NFKB1/CTSD/TNFRSF10B/TUBA1A/MAPK10/TNFRSF1A/TNF/CTSO/BAX/PMAIP1	2.26385988182803
NA	NA	hsa04081	Hormone signaling	26/745	219/9376	1.49413747663265	GNG2/GNG11/CSH1/SLC40A1/CGA/SLC16A10/IGF1/PRKG1/GNGT1/GNAI2/GNG10/AGTR1/PLCB1/GNA14/RAMP2/GNB4/GNG5/PRKACB/CSHL1/GNA15/SMAD5/GNAS/PLCB2/SMAD9/PLCB4/CCK	2.17383441364557
NA	NA	hsa04082	Neuroactive ligand signaling	24/745	199/9376	1.51781727429092	GNG2/GNG11/GNGT1/TAC3/GNAI2/GNG10/PRKCB/HRH1/PLCB1/PRKCA/P2RY1/GNB4/GNG5/HRH2/PRKACB/OGFRL1/GRIN2C/SLC1A2/GNAS/GRIA4/PLCB2/P2RY13/PLCB4/GABRA3	2.16913170853904
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	15/745	110/9376	1.71616839536303	CYBB/IGF1/RPS6/MKNK1/PRKCB/ELOB/LDHB/PRKCA/ANGPT1/NFKB1/TLR4/HIF1A/TEK/HMOX1/RBX1	2.21972187784857
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	12/745	82/9376	1.84174169258471	LGMN/B2M/HLA-C/HSPA1A/CD4/CTSS/HLA-A/CTSB/HLA-E/CREB1/HSPA8/TNF	2.24914599660087
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	21/745	173/9376	1.52768747332894	CCL2/ACTB/PYCARD/PRKCB/PRKCA/CDK6/NLRP3/ICAM1/NFKB1/TLR4/SOCS3/SLC25A5/SLC25A6/CASP1/IL33/TNFRSF10B/TNFRSF1A/RAB11A/TNF/BAX/TLR7	2.05810885630476
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	36/745	333/9376	1.36056593506258	SPP1/LAMA2/WNT2/COL1A1/COL1A2/COL6A1/HLA-C/RBPJ/MAGI1/CCND2/COL6A2/LAMA4/RB1/HLA-A/CDK6/ATP6V0B/NFKB1/ATP6V1F/HLA-E/ATP6V1G1/ATP6V0C/PRKACB/TNXB/ITGB5/PTGER4/TNFRSF1A/CREB1/GNAS/ATP6V0D1/ATP6V0E1/TNF/FZD2/LAMC3/ITGA4/ATP6V1A/BAX	1.96826586805811
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	14/745	105/9376	1.67803131991051	LAMA2/RYR2/IGF1/ACTB/DTNA/CACNB4/TPM3/PRKACB/ITGB5/GNAS/SGCA/TNF/TGFB3/ITGA4	2.05264729243783
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	12/745	86/9376	1.75607928827845	RYR2/ATP1B3/PRKCB/ATP1B1/PLCB1/PRKCA/PRKACB/CREB1/GNAS/PLCB2/PLCB4/CCK	2.06938799939083
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/745	68/9376	1.8507698381366	CD14/RUNX1T1/FCGR1A/RUNX1/DUSP6/CSF1R/SPI1/NFKB1/ITGAM/LEF1	2.06857642109556
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	28/745	253/9376	1.39283232087434	CD14/RPS27A/UBA52/UBB/ACTB/PYCARD/ITPR2/ARPC3/CYTH4/JUN/PLCB1/ELMO1/ARPC1B/NLRP3/NFKB1/PFN1/TLR4/MYL12A/ACTR2/CASP1/MAPK10/TNFRSF1A/PLCB2/TNF/PLCB4/BAX/RBX1/ARPC4	1.86093777744118
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	17/745	139/9376	1.5392013905654	HSPA1A/GNAI2/ITPR2/MMP2/JUN/PLCB1/CALM2/PRKACB/KCNJ5/CTSD/CALM3/CREB1/GNAS/HSPA8/PLCB2/CALML4/PLCB4	1.88159499043582
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	20/745	170/9376	1.48061587050928	MAGI1/TUBA1B/ACTB/RUNX1/ARPC3/JUN/MYL6/ARPC1B/WAS/PRKACB/MYL12A/ACTR2/MSN/CLDN5/MAP3K1/TUBA1A/MAPK10/RAPGEF6/JAM3/ARPC4	1.85789129253351
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/745	18/9376	2.79671886651752	MANBA/MAN2B1/FUCA1/NEU1	2.24159978634129
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	15/745	119/9376	1.58637414697423	CCL2/VCAM1/JUN/TNFRSF1B/JUNB/ICAM1/NFKB1/SOCS3/MAP3K8/CSF1/RHBDF2/MAPK10/TNFRSF1A/CREB1/TNF	1.89123884415808
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/745	44/9376	2.00219646125686	HLA-C/CD86/CD28/HLA-A/HLA-E/ICA1/TNF	1.95760494941351
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/745	44/9376	2.00219646125686	DYNLL1/PRKACB/DCTN4/CREB1/GNAS/RAB11A/ARHGDIB	1.95760494941351
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	23/745	205/9376	1.41200196431495	HLA-C/RBPJ/HDAC9/CCND2/LYN/JUN/RB1/SYK/HLA-A/CDK6/NFKB1/HLA-E/HDAC8/PRKACB/JAK3/YWHAB/CREB1/EGR2/ATP6V0D1/REL/RANBP1/BAX/PMAIP1	1.75227024649211
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/745	12/9376	3.14630872483221	CD209/NCAM2/FCGR2B	2.18567370655489
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	25/745	233/9376	1.35034709220267	LAMA2/DCN/COL3A1/COL1A1/COL1A2/COL6A1/VCAN/COL6A2/ACTB/ATP1B3/VIM/ANK2/ATP1B1/DTNA/ELN/COL5A2/TPM3/CAPZA2/TNNT3/ITGB5/TNNT1/SGCA/CAPZB/ITGA4/FBLN2	1.59098224923489
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/745	38/9376	1.98714235252561	IGF1/ATP1B3/PRKCB/ATP1B1/PRKCA/HSD11B2	1.79133934614412
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	13/745	107/9376	1.52904723075958	ITPR2/LDHB/PLCB1/CALM2/PRKACB/CALM3/CREB1/GNAS/PLCB2/CALML4/PPP3R1/PLCB4/PYGL	1.6169742708037
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	17/745	149/9376	1.43589928381604	FCER1G/LPAR6/CYTH4/AGTR1/SYK/PLD1/KITLG/PLCB1/PRKCA/PLPP3/PDGFC/PIK3CG/GNAS/PLCB2/PLCB4/PTGFR/PIK3R5	1.57573160406427
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/745	39/9376	1.93618998451213	HLA-C/CD86/CD28/HLA-A/HLA-E/TNF	1.72117817729272
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	7/745	49/9376	1.79789069990412	GNAI2/JUN/NFKB1/PRKACB/GRIN2C/CREB1/GNAS	1.64514306450423
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	12/745	99/9376	1.52548301810047	LAMA2/RYR2/IGF1/ACTB/DTNA/CACNB4/TPM3/ITGB5/SGCA/TNF/TGFB3/ITGA4	1.54420772559263
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/745	52/9376	1.69416623644812	CD36/PLTP/NPC2/APOE/TSPO/LRP1/MYLIP	1.47467813783089
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	11/745	93/9376	1.48857617088836	RBPJ/IL12RB2/MAF/CD4/JUN/NFKB1/JAK3/NFATC2/MAPK10/PPP3R1/IL2RA	1.3911142418226
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	23/745	226/9376	1.2807982419671	RYR2/CGA/PDE4D/GNAI2/ATP1B3/PDE4B/ATP1B1/JUN/ATP2B1/PLD1/CALM2/NFKB1/RAC2/VAV1/PRKACB/CALM3/GRIN2C/MAPK10/CREB1/GNAS/GRIA4/CALML4/ABCC4	1.25536863353026
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/745	65/9376	1.54895198760971	ITPR2/AGTR1/PLCB1/PRKACB/CREB1/GNAS/PLCB2/PLCB4	1.30474635766712
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	10/745	86/9376	1.4633994068987	LAMA2/RYR2/ACTB/DTNA/CACNB4/GJA1/ITGB5/LEF1/SGCA/ITGA4	1.26832355604463
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/745	45/9376	1.67803131991051	HLA-C/CD86/CD28/HLA-A/HLA-E/TNF	1.33944576636973
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/745	76/9376	1.49035676439421	CD36/PLTP/FABP5/SLC27A4/MMP1/DBI/GK/ME1/FABP4	1.26098728903596
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/745	76/9376	1.49035676439421	IGF1/PRKCB/RB1/PRKCA/CDK6/CALM2/CALM3/CALML4/BAX	1.26098728903596
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/745	17/9376	2.22092380576392	CD209/NRP2/PCDH11X	1.48023788429014
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	17/745	163/9376	1.31257051097295	PRKCB/JUN/RB1/PRKCA/NFKB1/TLR4/JAK3/NFATC2/YWHAB/MAP3K1/MAPK10/CREB1/EGR2/TLR2/TNF/TGFB3/BAX	1.18269969714513
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/745	66/9376	1.52548301810047	IL12RB2/MAF/JUN/NFKB1/TLR4/TLR2/TNF/TGFB3	1.25860377250872
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/745	78/9376	1.4521424883841	ACTB/CLTA/ARPC3/CLTC/ELMO1/ARPC1B/ACTR2/CAV1/ARPC4	1.178042793335
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	15/745	144/9376	1.31096196868009	RBPJ/ITPR2/PRKCB/PLCB1/PRKCA/SLC25A5/RYR1/PSMA7/GRIN2C/SLC25A6/MAPK10/PLCB2/ATXN1/PLCB4/PSMB1	1.10477500895263
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	13/745	122/9376	1.34104962042029	PTPRC/CD28/CD4/JUN/LCP2/NFKB1/VAV1/MAP3K8/NFATC2/TEC1/MAPK10/PPP3R1/TNF	1.11395065843621
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	13/745	122/9376	1.34104962042029	SLC16A10/ACTB/ATP1B3/PRKCB/ATP1B1/BMP4/PLCB1/PRKCA/TBC1D4/PRKACB/HIF1A/PLCB2/PLCB4	1.11395065843621
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/745	48/9376	1.57315436241611	ATP1B3/PRKCB/ATP1B1/PLCB1/PLCB2/PLCB4	1.16958332687874
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	17/745	168/9376	1.27350591243209	FTL/CYBB/PYCARD/NLRP3/TLR4/SLC25A5/PPIA/JAK3/SLC25A6/CASP1/IL33/TNFRSF10B/MAPK10/TNFRSF1A/TNF/PYGL/BAX	1.05092547772358
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	16/745	157/9376	1.28257170948574	HLA-C/CCND2/ITPR2/RB1/HLA-A/CDK6/CALM2/NFKB1/HLA-E/SLC25A5/CALM3/NFATC2/SLC25A6/CALML4/PPP3R1/TGFB3	1.04898629452717
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	9/745	80/9376	1.4158389261745	HGF/IGF1/RPS6/GAS6/PRKCB/PRKCA/PDGFC/KDR/BAX	1.09737558339688
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/745	29/9376	1.73589446887295	GNGT1/CALM2/CALM3/CALML4	1.16603512366201
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	20/745	205/9376	1.22782779505647	B2M/HLA-C/RBPJ/CCND2/LYN/VIM/JUN/RB1/SYK/HLA-A/CDK6/ICAM1/NFKB1/HLA-E/JAK3/MAPK10/TLR2/ITGAL/TNF/BAX	0.968965930211417
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/745	93/9376	1.35325106444396	ACTB/PTPRJ/PTPRB/RAC2/WAS/CDH5/LMO7/MYL12A/NLK/LEF1	1.0058054730616
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/745	61/9376	1.44420728352954	FTL/SLC40A1/ATP1B3/ATP1B1/ATP2B1/ATOX1/HMOX1	1.02256842741367
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	9/745	83/9376	1.36466402522843	CCL4/CCL4L2/IFI16/PYCARD/NLRP3/NFKB1/POLR2L/CASP1/IL33	0.980363684519746
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/745	30/9376	1.67803131991051	FOLR2/NFKB1/ABCC4/TNF	1.09277489901691
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	22/745	232/9376	1.19342744735015	TMSB4X/ACTB/ITGB2/ARPC3/NCKAP1L/ARPC1B/CFL1/PDGFC/FGF7/PFN1/RAC2/VAV1/ITGAM/MYL12A/ACTR2/MSN/BRK1/ITGB5/ITGAL/ITGA4/CXCL12/ARPC4	0.876450111300876
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	8/745	73/9376	1.37920382458398	HGF/RARB/PRKCB/RB1/PRKCA/CDK6/JAK3/BAX	0.955555342029071
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/745	52/9376	1.4521424883841	CGA/IGF1/HSD17B2/HSD17B1/PRKACB/GNAS	0.96052589105481
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/745	31/9376	1.62390127733276	SRP14/SEC61G/SEC61B/SEC11A	1.02221037631612
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/745	32/9376	1.57315436241611	MAPK10/TNFRSF1A/BAX/PMAIP1	0.954142833791161
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	11/745	109/9376	1.27006957699649	CD36/PRKCB/SLC27A4/NFKB1/TBC1D4/SOCS3/MAPK10/TNFRSF1A/CREB1/TNF/PYGL	0.833206305526988
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	15/745	155/9376	1.21792595799957	WNT2/GNAI2/ITPR2/AGTR1/RB1/PLCB1/CDK6/PRKACB/CDKN2C/CREB1/GNAS/PLCB2/LEF1/FZD2/PLCB4	0.803746358242135
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/745	98/9376	1.28420764278866	ITPR2/PRKCB/PLCB1/PRKCA/INPP5D/CALM2/CALM3/PLCB2/CALML4/PLCB4	0.830911601188726
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/745	54/9376	1.39835943325876	HLA-C/CGA/CD86/CD28/HLA-A/HLA-E	0.862483216591097
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	10/745	99/9376	1.27123584841706	PRKCB/JUN/PLD1/PRKCA/PLPP3/PDGFC/RAC2/WAS/HIF1A/MAPK10	0.797065705562363
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	8/745	77/9376	1.30755687265754	RB1/PLD1/CDK6/NFKB1/RAC2/MAPK10/TGFB3/BAX	0.796133486238104
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	15/745	158/9376	1.19480078158185	WNT2/IGF1/RPS6/PRKCB/PRKCA/LAMTOR4/ATP6V1F/ATP6V1G1/LAMTOR2/LRP6/LAMTOR1/TNFRSF1A/TNF/FZD2/ATP6V1A	0.725494464075837
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/745	23/9376	1.64155237817333	AGTR1/ATP6AP2/PRCP	0.905010850833073
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	16/745	170/9376	1.18449269640742	WNT2/HGF/ACTB/PRKCB/RB1/PRKCA/CDK6/MGST2/GSTA4/LRP6/HMOX1/LEF1/FZD2/TGFB3/MGST3/BAX	0.713183636296007
Cellular Processes	Cell motility	hsa04814	Motor proteins	18/745	194/9376	1.16770220715422	TUBA1B/ACTB/MYL6/KIF1B/MYO5A/TPM3/CAPZA2/DYNLL1/MYO1F/MYO1B/MYL12A/TNNT3/DCTN4/TNNT1/TUBA1A/DNAH8/CAPZB/MYO7A	0.69343253678539
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/745	56/9376	1.34841802492809	DISP1/CCND2/ARRB2/GRK3/PRKACB/GAS1	0.768280637621802
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/745	90/9376	1.25852348993289	CD28/CD4/JUN/NFKB1/TLR4/NFATC2/HIF1A/TLR2/PPP3R1	0.72400262592043
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/745	46/9376	1.36796031514444	PSMB8/PSMA7/POMP/PSMB1/PSMB9	0.734974535397929
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/745	70/9376	1.25852348993289	CD36/TNFRSF1B/NFKB1/SOCS3/MAPK10/TNFRSF1A/TNF	0.637823802318828
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	10/745	105/9376	1.19859379993608	RPS27A/UBA52/UBB/TOMM7/JUN/GABARAP/PRKN/HIF1A/GABARAPL2/MAPK10	0.601215627896864
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/745	59/9376	1.27985439654192	HPGDS/LAP3/GPX4/MGST2/GSTA4/MGST3	0.633509757578758
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/745	59/9376	1.27985439654192	CGA/PRKG1/GNAI2/PRKACB/FABP4/GNAS	0.633509757578758
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	13/745	142/9376	1.15216939219208	RPS27A/WWP1/UBA52/UBB/ELOB/PIAS2/SOCS3/PRKN/UBE2W/RHOBTB1/MAP3K1/CDC27/RBX1	0.53679660355043
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/745	37/9376	1.36056593506258	NCOA4/TPM3/LEF1/BAX	0.645607525956157
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/745	60/9376	1.25852348993289	PRKCB/PRKCA/KDR/RAC2/NFATC2/PPP3R1	0.590193077918819
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	11/745	120/9376	1.15364653243848	JUN/CALM2/NFKB1/SH2B3/CALM3/MAP3K1/MAPK10/CALML4/ARHGDIB/MAP2K5/BAX	0.497662514641176
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	13/745	144/9376	1.13616703952274	CD14/C1QA/C1QC/C1QB/LY96/C2/C3AR1/NFKB1/TLR4/MAPK10/TNFRSF1A/LEF1/TNF	0.483769584255994
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/745	73/9376	1.20680334651099	BST2/CD4/BICD1/PPIA/FEZ1/SERINC5/APOBEC3C	0.521123548067738
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/745	73/9376	1.20680334651099	HGF/IGF1/RB1/CDK6/PDGFC/FGF7/BAX	0.521123548067738
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/745	50/9376	1.25852348993289	CD86/CD28/TNFSF13B/ITGA4/CXCL12	0.538481172160954
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/745	109/9376	1.15460870636045	RUNX1/CD4/JUN/NFKB1/JAK3/NFATC2/HIF1A/MAPK10/PPP3R1/IL2RA	0.476991708809053
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/745	51/9376	1.23384655875773	ENPP2/PLD1/PLPP3/PLD3/LPCAT2	0.491954420564808
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	7/745	75/9376	1.17462192393736	IGF1/CCND2/CDK6/TNFRSF10B/SESN3/BAX/PMAIP1	0.446064636907273
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	8/745	87/9376	1.15726297924863	AREG/JUN/RAC2/MAPK10/LEF1/TGFB3/BAX/PMAIP1	0.43294712494246
NA	NA	hsa04519	Cadherin signaling	34/745	404/9376	1.05915343212174	WNT2/PRICKLE1/CDH11/ACTB/VIM/PCDH10/ARPC3/NCKAP1L/ARPC1B/PCDH12/SCN1B/GJA1/NFKB1/KDR/RAC2/VAV1/CDH5/PCDH18/MYO1F/MYO1B/EVL/LRP6/ACTR2/BRK1/PCDH11X/TMC8/YWHAB/KRT1/MAPK10/LEF1/FZD2/MYO7A/GABRA3/ARPC4	0.357074810281911
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	9/745	99/9376	1.14411226357535	IGF1/MMP2/JUN/RB1/PRKACB/CDKN2C/MAPK10/GNAS/BAX	0.423494695547231
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/745	41/9376	1.22782779505647	MMP2/RB1/MMP1/TYMP	0.429511395293966
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/745	77/9376	1.14411226357535	RUNX1/RB1/CDK6/NFKB1/MECOM/TGFB3/BAX	0.373045147125229
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	11/745	128/9376	1.08154362416107	GUCY1A2/PDE4D/PDE4B/ENPP1/GUCY1A1/NME2/GUCY1B1/APRT/NME3/PDE9A/IMPDH1	0.272900480334968
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/745	55/9376	1.14411226357535	PLPP3/ASAH1/SGMS1/NEU1/GLA	0.314908401007806
Human Diseases	Substance dependence	hsa05034	Alcoholism	16/745	191/9376	1.05426051512702	GNG2/GNG11/HDAC9/GNGT1/GNAI2/GNG10/CALM2/GNB4/GNG5/HDAC8/PRKACB/CALM3/GRIN2C/CREB1/GNAS/CALML4	0.222584148265998
NA	NA	hsa04981	Folate transport and metabolism	3/745	31/9376	1.21792595799957	FOLR2/SLCO2B1/ABCC4	0.357053565410441
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/745	19/9376	1.32476156835041	ARSB/HYAL2	0.41629992443571
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	8/745	93/9376	1.08260085155517	LAMA2/RARB/LAMA4/RB1/CDK6/NFKB1/LAMC3/BAX	0.235187935539592
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/745	56/9376	1.12368168744008	ST6GAL1/MAN1A1/KRTCAP2/TMEM258/DAD1	0.272724827334102
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/745	44/9376	1.14411226357535	MAN1A1/KRTCAP2/TMEM258/DAD1	0.281496584105364
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/745	32/9376	1.17986577181208	GABARAP/ATG7/GABARAPL2	0.299426556740083
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	14/745	169/9376	1.04256383781423	RPS27A/UBA52/UBB/GABARAP/ATG7/CTSB/TANK/PRKACB/CTSD/HIF1A/GABARAPL2/VAMP8/MAPK10/C9orf72	0.164043216686544
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/745	82/9376	1.07434932067442	NME2/MGST2/GSTA4/NME3/IMPDH1/MGST3/TYMP	0.198662461914378
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/745	70/9376	1.07873441994247	HGF/JUN/ELOB/HIF1A/TGFB3/RBX1	0.194251930894608
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/745	71/9376	1.06354097740807	CGA/CCND2/NFKB1/SOCS3/TNFRSF11A/MAPK10	0.157891260872624
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/745	21/9376	1.19859379993608	CHSY3/CSGALNACT2	0.267661959789832
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/745	34/9376	1.11046190288196	BHLHE41/CREB1/RBX1	0.189568102799508
Organismal Systems	Sensory system	hsa04742	Taste transduction	7/745	86/9376	1.02437958482909	SCN9A/PLCB1/P2RY1/PRKACB/PLCB2/PLCB4/GABRA3	0.0667268910253186
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/745	22/9376	1.14411226357535	HNMT/ASPA	0.198813931560068
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/745	36/9376	1.04876957494407	KL/AKR1B1/CRYL1	0.0861311010480318
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/745	23/9376	1.09436825211555	ATP1B3/ATP1B1	0.133121308632501
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/745	10/9376	1.25852348993289	SELENBP1	0.240301316210501
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/745	63/9376	0.998828166613401	PTGDS/HPGDS/TBXAS1/LTC4S/GPX4	-0.00274172919628165
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/745	63/9376	0.998828166613401	WNT2/BMP4/LEF1/FZD2/BAX	-0.00274172919628165
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	14/745	180/9376	0.978851603281133	CCL2/B2M/HLA-C/BST2/SYK/HLA-A/NFKB1/POU2F2/HLA-E/SOCS3/TNFRSF1A/TLR2/TNF/BAX	-0.0841680830621765
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	7/745	90/9376	0.978851603281133	IGF1/NFKB1/PRKACB/KL/CREB1/SESN3/BAX	-0.0592267061010251
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	11/745	143/9376	0.968094992256066	C1QA/FCGR3A/C1QC/C1QB/FCGR2A/CD86/FCGR1A/CD28/C2/C1R/TNF	-0.112950633636331
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/745	38/9376	0.993571176262805	PTPRC/CD4/JAK3	-0.0116662048593082
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	12/745	157/9376	0.961928782114308	BMP5/WNT2/AREG/CCND2/ACTB/ITGB2/BMP4/YWHAB/LEF1/FZD2/TGFB3/ID1	-0.141331153959925
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/745	106/9376	0.949829049005952	FOLR2/IGF1/RB1/PDGFC/NFKB1/ETV5/CREB1/LEF1	-0.152615489865257
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/745	94/9376	0.937198343567043	CCL2/S100A9/JUN/MMP1/NFKB1/MAPK10/TNF	-0.179782518382302
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	13/745	174/9376	0.940276170639513	HSPA1A/MAN1A1/KRTCAP2/PRKN/SSR4/TMEM258/SEC61G/DAD1/SEC61B/MAPK10/HSPA8/BAX/RBX1	-0.23362234124552
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/745	41/9376	0.920870846292355	GRIN2C/GRIA4/GABRA3	-0.149177905219933
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/745	27/9376	0.932239622172508	ELOVL2/HACD4	-0.10358773506883
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/745	42/9376	0.898945349952061	IDO2/INMT/IDO1	-0.192832515048568
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/745	70/9376	0.898945349952061	HPGDS/SULT1A1/MGST2/GSTA4/MGST3	-0.249319940529612
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/745	28/9376	0.898945349952061	ELOVL2/HACD4	-0.157329145007192
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	10/745	138/9376	0.911973543429628	IGF1/ITPR2/CALM2/PRKACB/CALM3/YWHAB/CALML4/PPP3R1/CDC27/RBX1	-0.306053253458818
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	10/745	138/9376	0.911973543429628	RPS6/MKNK1/CALM2/SOCS3/PRKACB/CALM3/MAPK10/CALML4/PYGL/PRKAR1A	-0.306053253458818
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/745	43/9376	0.878039644139223	CD36/SLC27A4/PLPP3	-0.23549163991506
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/745	85/9376	0.888369522305567	ENPP1/NME2/APRT/NME3/IMPDH1/TYMP	-0.30373457537501
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/745	72/9376	0.873974645786726	NFKB1/TANK/MAP3K1/MAPK10/TNF	-0.315371570180023
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/745	59/9376	0.853236264361279	ENPP1/NME2/NME3/TYMP	-0.332230830513013
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	11/745	156/9376	0.887420409568061	CD81/RB1/CDK6/NFKB1/EIF3E/SOCS3/YWHAB/CLDN5/TNFRSF1A/TNF/BAX	-0.416571658430101
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	27/745	370/9376	0.918382006167241	KISS1/CSH1/SPX/CGA/TAC3/LPAR6/AGTR1/HRH1/C3AR1/TSPO/P2RY1/HRH2/OGFRL1/PTAFR/NPB/LYPD6/GRIN2C/CSHL1/PTGER4/GRIA4/P2RY13/APLNR/CCK/APLN/PTGFR/GABRA3/FPR1	-0.470602275314829
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/745	144/9376	0.873974645786726	WNT2/IGF1/BMP4/JAK3/ACVR2A/DUSP9/SMAD5/SMAD9/FZD2/ID1	-0.447738552788954
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/745	46/9376	0.820776189086665	FTL/BLVRB/HMOX1	-0.357986803839341
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/745	75/9376	0.839015659955257	MGST2/GSTA4/MGST3/BAX/PMAIP1	-0.411227980832317
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/745	104/9376	0.847083118224058	PLD1/PLPP3/SGMS1/PLD3/PHOSPHO1/LPCAT2/ETNK1	-0.460700419710384
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/745	47/9376	0.803312865914608	LDHB/ME1/ME2	-0.397137183076962
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/745	47/9376	0.803312865914608	SOCS3/MAPK10/TNF	-0.397137183076962
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/745	16/9376	0.786577181208054	GLA	-0.251012954086431
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/745	32/9376	0.786577181208054	AKR1B1/GLA	-0.355289720310994
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/745	32/9376	0.786577181208054	LDHB/ACSS3	-0.355289720310994
Human Diseases	Immune disease	hsa05310	Asthma	2/745	32/9376	0.786577181208054	FCER1G/TNF	-0.355289720310994
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/745	62/9376	0.811950638666378	IGF1/HSPA1A/PRKACB/HSPA8	-0.436448300781922
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	9/745	133/9376	0.85163243679669	IGF1/CCND2/KLF2/GABARAP/NLK/GABARAPL2/MAPK10/SGK3/TGFB3	-0.506280877433761
NA	NA	hsa03272	Virion - Hepatitis viruses	3/745	48/9376	0.786577181208054	CD81/CD63/CLDN5	-0.435512292678499
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/745	63/9376	0.799062533290721	PRDM6/SMYD3/MECOM/CAMKMT	-0.470131782729706
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	10/745	148/9376	0.850353709414112	WNT2/IGF1/JUN/RB1/CDK6/FGF7/LRP6/LEF1/FZD2/BAX	-0.539108571760303
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/745	33/9376	0.762741509050234	VAMP5/VAMP8	-0.40111488226923
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/745	78/9376	0.806745826880055	PLCB1/INPP5D/PIK3CG/PLCB2/PLCB4	-0.503517567525008
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/745	17/9376	0.740307935254639	INMT	-0.314848502970334
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	10/745	150/9376	0.839015659955257	WNT2/HGF/RARB/RB1/FGF7/LRP6/LEF1/FZD2/TGFB3/BAX	-0.583923228967423
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/745	65/9376	0.774475993804853	PLPP3/GK/AKR1B1/GLA	-0.536024337812988
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/745	50/9376	0.755114093959732	LAP3/GATM/SAT2	-0.510075311781124
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/745	36/9376	0.699179716629381	ENPP1/PYGL	-0.531273488727463
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/745	20/9376	0.629261744966443	NPL	-0.487607648258522
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/745	38/9376	0.662380784175203	ENPP1/NAMPT	-0.612668055193783
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/745	86/9376	0.731699703449352	AREG/PRKCB/JUN/PRKCA/MAPK10	-0.734337552320887
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/745	21/9376	0.599296899968041	ENPP1	-0.540062061770987
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	14/745	217/9376	0.811950638666378	GNAI2/PRKCB/JUN/RB1/PRKCA/ARRB2/FGF7/NFKB1/MGST2/PRKACB/GSTA4/CREB1/GNAS/MGST3	-0.823400102006456
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/745	73/9376	0.689601912291992	HPGDS/MGST2/GSTA4/MGST3	-0.782171833816262
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/745	90/9376	0.699179716629381	ATP1B3/ATP1B1/PRKACB/GNAS/ABCC4	-0.84245603812248
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/745	24/9376	0.524384787472036	HS2ST1	-0.685397198730129
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/745	79/9376	0.637227083510322	HPGDS/MGST2/GSTA4/MGST3	-0.95128402342677
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/745	26/9376	0.484047496128033	HHEX	-0.773969433226039
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	9/745	158/9376	0.716880468949112	CCND2/RB1/CDK6/HDAC8/YWHAB/CDKN2C/TGFB3/CDC27/RBX1	-1.05441903662413
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/745	27/9376	0.466119811086254	HMGCLL1	-0.816161912622282
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/745	28/9376	0.449472674976031	AKR1B1	-0.857100522420587
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/745	66/9376	0.572056131787675	HSD17B2/HSD17B1/HSD11B2	-1.02498415438999
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/745	29/9376	0.433973617218237	RASSF4	-0.896876754969667
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/745	49/9376	0.513683057115464	ST6GAL1/GXYLT2	-1.00271997885617
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/745	31/9376	0.405975319333189	PGLS	-0.973260056400921
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/745	31/9376	0.405975319333189	KL	-0.973260056400921
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/745	168/9376	0.674209012464046	CSH1/IL12RB2/CCND2/PIAS2/SOCS3/JAK3/IL10RA/CSHL1/IL2RA	-1.25182686608018
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/745	34/9376	0.370153967627319	POLR2L	-1.08090404291042
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/745	110/9376	0.572056131787675	IGF1/GNAI2/PRKACB/MAPK10/CDC27	-1.32638688458254
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/745	35/9376	0.359578139980825	AKR1B1	-1.11515875931369
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/745	57/9376	0.441587189450135	ELOVL2/HACD4	-1.24234255325331
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/745	37/9376	0.340141483765645	ASPA	-1.18150269540362
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/745	59/9376	0.426618132180639	LEF1/BAX	-1.29797141860478
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/745	62/9376	0.405975319333189	RBPJ/ATXN1	-1.37868621653861
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/745	63/9376	0.399531266645361	POLR2L/RBX1	-1.40491188979655
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/745	41/9376	0.306956948764118	GATM	-1.30655650624773
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/745	45/9376	0.279671886651752	ABCC4	-1.42300276327758
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/745	71/9376	0.354513659136024	LDHB/HIF1A	-1.60395159773104
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/745	48/9376	0.262192393736018	HMGCLL1	-1.50557603904999
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/745	78/9376	0.322698330752022	BTG3/PABPC4L	-1.76468783817001
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/745	54/9376	0.233059905543127	LDHB	-1.66049277203929
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/745	108/9376	0.349589858314691	SUMO2/SUMO1/SAP18	-1.99728199027377
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/745	116/9376	0.325480212913677	ME1/PGLS/ME2	-2.14759019157608
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/745	67/9376	0.187839326855655	LDHB	-1.96002250745552
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/745	68/9376	0.18507698381366	DHRS4L2	-1.98141784149673
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/745	122/9376	0.309472989327759	CD36/IGF1/CREB1	-2.2554284542478
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/745	103/9376	0.244373493190852	SAP18/PABPC4L	-2.26542079632555
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/745	154/9376	0.326889218164386	IDO2/NME2/NME3/IDO1	-2.47438665564198
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/745	83/9376	0.151629336136492	MBD5	-2.28076183095576
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/745	83/9376	0.151629336136492	HMGCLL1	-2.28076183095576
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	12/745	323/9376	0.467562906476614	ZEB2/MARCKS/CCND2/VIM/PRKCB/FSCN1/PRKCA/CDK6/NFKB1/TNXB/HMOX1/STMN1	-2.86092531943213
NA	NA	hsa04382	Cornified envelope formation	6/745	217/9376	0.347978845142733	S100A9/S100A4/S100A6/SLC27A4/KRT1/CLDN5	-2.8549646838064
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/745	117/9376	0.107566110250674	ACTB	-2.85377782599703
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/745	183/9376	0.137543550812337	NOP10/RPP25	-3.46152366568214
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/745	243/9376	0.10358218024139	HSPA1A/HSPA8	-4.1594902005528
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/745	449/9376	0.196206334733412	PRKG1/ARRB2/CALM2/GRK3/PRKACB/CALM3/CALML4	-5.12800214956648