category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	39/498	250/9376	2.93706024096386	GLB1/GNS/MANBA/GAA/LGMN/SLC38A9/MCOLN3/CTSL/NAGLU/SMPD1/PSAP/SLC17A5/ENTPD4/CLTC/CTSC/GM2A/VPS13C/HGSNAT/CTBS/PLA2G15/ATP6V1B1/TLR3/SORT1/HEXA/CTSV/HEXB/NPC1/CTSO/OSBPL3/SLC29A3/HYAL2/SCARB2/SLC15A4/CTSF/AP3M1/ABCA5/LAMP1/AP4E1/CLN5	7.35217165978033
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	31/498	174/9376	3.35429072612288	RRBP1/GANAB/CANX/CKAP4/LMAN1/P4HB/HSP90B1/PDIA4/RPN2/MOGS/HSPA4L/ERLEC1/TUSC3/EDEM3/OS9/SEC63/STT3B/PRKCSH/WFS1/MAN1B1/UBXN4/MAN1A2/SEL1L/DDOST/SIL1/HSPA8/SEC31A/MAN1C1/PDIA3/HSPA5/CALR	7.42397226575752
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	36/498	238/9376	2.84782828794168	EGFR/RPL39/RPS29/RPS28/NRP1/RPS27/RPL34/RPL36/RPL28/FAU/IL6ST/RPS15/RPL37A/RPL18/RPS12/RPL12/RPS15A/RPLP2/RPS14/RPS27A/RPLP1/RPS23/RPL37/TLR3/RPL10/RPL41/RPL21/RPS21/RPL35A/RPS19/RPS24/RPL32/MAVS/RPS13/RPS18/PIK3CB	6.83860079196636
NA	NA	hsa04518	Integrin signaling	26/498	154/9376	3.17863662441976	FN1/FBN1/LAMC1/LAMB1/ITGA6/LAMA5/EGFR/MET/COL4A2/ITGB8/IGF1R/ITGB4/ITGB5/CDH1/ITGAV/FRAS1/FLT1/COL4A1/PDGFD/ITGB1/LAMB2/CTNNB1/CCND1/FERMT1/FREM2/PIK3CB	6.45617569987412
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	18/498	89/9376	3.80777040747259	FN1/LAMC1/LAMB1/ITGA6/LAMA5/DAG1/COL4A2/ITGB8/ITGB4/ITGB5/ITGAV/FRAS1/COL4A1/HSPG2/ITGB1/CD47/LAMB2/FREM2	6.30320761656146
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	12/498	44/9376	5.13472070098576	FUT8/MAN2A1/RPN2/B4GALT1/TUSC3/STT3B/MAN1B1/HEXA/HEXB/MAN1A2/DDOST/MAN1C1	6.51070309512027
Genetic Information Processing	Translation	hsa03010	Ribosome	30/498	222/9376	2.54423097796592	RPL39/RPS29/RPS28/RPS27/RPL34/RPL36/RPL28/FAU/RPS15/RPL37A/RPL18/RPS12/RPL12/RPS15A/RPLP2/RPS14/RPS27A/RPLP1/RPS23/RPL37/RPL10/RPL41/RPL21/RPS21/RPL35A/RPS19/RPS24/RPL32/RPS13/RPS18	5.51475258280023
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	28/498	204/9376	2.58414048350264	FN1/EGFR/MET/IGF1R/ITGB5/ITGAV/HSPG2/TIMP3/ITGB1/CTSL/ERBB3/SLC9A1/GPC3/ANK3/GPC1/CTNNB1/PPP1R12B/CCND1/FZD3/IQGAP1/GAB1/ITPR2/KRAS/RDX/PIK3CB/FZD5/IGF2/ROCK1	5.41775663456494
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	13/498	56/9376	4.37062535857717	GANAB/FUT8/MAN2A1/RPN2/B4GALT1/MOGS/TUSC3/STT3B/MAN1B1/MGAT3/MAN1A2/DDOST/MAN1C1	5.99155127616126
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	17/498	93/9376	3.44155115083992	EGFR/MET/IGF1R/CDH1/PTPRF/PTPRM/LMO7/TJP1/CTNND1/CTNNB1/IQGAP1/TCF7L2/SORBS1/SMURF2/TGFBR2/WASL/ROCK1	5.60409986145846
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	29/498	233/9376	2.34331316683041	FN1/FBN1/FBN2/ITGA6/DAG1/COL4A2/ITGB8/FBLN1/ITGB4/ITGB5/ITGAV/BGN/SYNE2/COL4A1/PLEC/DIAPH2/HSPG2/SUN1/DSC2/ITGB1/SPTAN1/DMD/COL5A2/ANK3/DSG2/SPTBN1/DSP/MYH10/INF2	4.91760465803829
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	26/498	203/9376	2.41137950818051	FN1/LAMC1/LAMB1/ITGA6/LAMA5/EGFR/MET/COL4A2/ITGB8/IGF1R/ITGB4/ITGB5/ITGAV/FLT1/COL4A1/ARHGAP5/PDGFD/ITGB1/LAMB2/CTNNB1/PPP1R12B/MYLK3/CCND1/RAPGEF1/PIK3CB/ROCK1	4.81480684263956
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	22/498	157/9376	2.63822167651498	CDH1/TEAD1/DLG5/FRMD6/BMPR1A/BMP7/RASSF6/AMOT/DVL3/BMPR2/CTNNB1/CCND1/FZD3/YAP1/TCF7L2/PRKCI/LATS1/LATS2/WWTR1/TGFBR2/FZD5/PARD6B	4.90256461215467
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	7/498	19/9376	6.93637708729655	GLB1/GNS/NAGLU/HGSNAT/HEXA/HEXB/HYAL2	6.13440867187678
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	24/498	184/9376	2.45573598742797	SEMA6D/MET/PLXNB1/SEMA6A/NRP1/PLXNA1/PLXNB2/ITGB1/SEMA3F/BMP7/EFNA4/EPHB4/NTN4/RASA1/BMPR2/LRIG2/ROBO1/FZD3/KRAS/SEMA3C/EFNA1/PIK3CB/PARD6B/ROCK1	4.72312306115167
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	37/498	362/9376	1.9243382369256	FN1/LAMC1/LAMB1/ITGA6/LAMA5/EGFR/MET/COL4A2/ITGB8/CSF3R/IGF1R/ITGB4/ITGB5/ITGAV/FLT1/COL4A1/CDK6/CREB3L2/PRLR/PDGFD/HSP90B1/ITGB1/ERBB3/LAMB2/EFNA4/FGFR2/CSH1/PHLPP1/CCND1/PKN2/KRAS/IL4R/SGK3/GNG12/EFNA1/PIK3CB/IGF2	4.24784994008923
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	27/498	232/9376	2.19110926464479	FN1/ITGA6/EGFR/ITGB8/ITGB4/ITGB5/ITGAV/SCIN/DIAPH2/PDGFD/ITGB1/IQGAP2/SLC9A1/FGFR2/PPP1R12B/MYLK3/IQGAP1/GNA12/MYH10/CYFIP1/KRAS/ARHGEF7/GNG12/RDX/WASL/PIK3CB/ROCK1	4.35081107799154
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	14/498	86/9376	3.06491080601476	ITGA6/DAG1/ITGB8/ITGB4/ITGB5/ITGAV/DSC2/ITGB1/DMD/GJA1/DSG2/CTNNB1/DSP/TCF7L2	4.55601772350989
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	6/498	17/9376	6.64493267186393	DAG1/NRP2/PCDH11X/TFRC/MYH10/LAMP1	5.51710491439449
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	14/498	93/9376	2.83421859480934	FN1/LAMC1/LAMB1/ITGA6/LAMA5/COL4A2/ITGAV/COL4A1/CDK6/ITGB1/LAMB2/CCND1/SKP2/PIK3CB	4.21008757875888
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	33/498	333/9376	1.86576938384167	FN1/LAMC1/LAMB1/ITGA6/LAMA5/EGFR/COL4A2/ITGB8/ITGB4/ITGB5/ITGAV/COL4A1/CDK6/CREB3L2/ITGB1/LAMB2/JAG1/DVL3/CTNNB1/NOTCH3/ATP6V1B1/TLR3/UBR4/CCND1/FZD3/TCF7L2/PRKCI/PSEN1/KRAS/PIK3CB/FZD5/MAML2/PARD6B	3.80987576713916
NA	NA	hsa04517	IgSF CAM signaling	30/498	299/9376	1.8890276826369	NRP2/APP/CDH1/NRCAM/NRP1/PTPRF/PLXNA1/LMO7/ITGB1/SPTAN1/ANK3/SPTBN1/RASA1/TJP1/CTNNB1/MYLK3/ROBO1/NLGN4X/CADM1/IQGAP1/MYH10/F11R/EPB41L3/SORBS1/PRKCI/RDX/WASL/PPFIA1/PIK3CB/PARD6B	3.70017657982248
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/498	21/9376	5.37923121055651	CHPF/B3GAT3/CHST12/CHST14/XYLT1/DSE	4.75804303697048
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	7/498	29/9376	4.54452291926326	TEAD1/FRMD6/RASSF6/YAP1/LATS1/LATS2/WWTR1	4.52755156988445
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	6/498	24/9376	4.70682730923695	EXTL2/HS6ST2/B3GAT3/EXT2/XYLT1/GLCE	4.30624232235486
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	14/498	106/9376	2.48662574827612	EGFR/SPINT1/IGF1R/CREB3L2/SLC19A1/PDGFD/HSP90B1/FGFR2/CTNNB1/FOLR1/CCND1/TCF7L2/KRAS/PIK3CB	3.6455029606954
NA	NA	hsa04519	Cadherin signaling	36/498	404/9376	1.67768102111416	EGFR/MET/LRP5/IGF1R/CDH1/DSC3/GABRE/TEAD1/DSC2/FAT1/PCDH11X/PSEN2/GJA1/DSG2/KRT80/TJP1/TAOK1/DVL3/CTNND1/CTNNB1/TMC5/DSP/NCSTN/FZD3/YAP1/MYO7A/TCF7L2/CYFIP1/PSEN1/LATS1/KRAS/LATS2/WWTR1/AMOTL1/FZD5/ROCK1	3.29772253832396
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	9/498	55/9376	3.08083242059146	PLPP3/GLB1/SMPD1/PSAP/SGPP1/GM2A/DEGS1/HEXA/HEXB	3.66547224860422
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	17/498	157/9376	2.03862584094339	LRP1/ITGB5/ITGAV/ANO6/ABCA1/CD47/DNMT3A/TMEM30B/SLC2A1/PLA2G15/ADAM9/TMEM30A/P2RY6/PBX1/XKR8/CALR/RAB7B	3.10820590770757
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	9/498	62/9376	2.73299650213758	TLE4/PSEN2/JAG1/DVL3/DTX4/NOTCH3/NCSTN/PSEN1/MAML2	3.24241166617553
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	16/498	150/9376	2.00824631860776	EGFR/MET/LRP5/CDH1/FGFR2/DVL3/CTNNB1/CCND1/FZD3/TCF7L2/GAB1/ABCB1/KRAS/TGFBR2/PIK3CB/FZD5	2.94814125796041
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/498	75/9376	2.51030789825971	LRP2/CREB3L2/CANX/HSP90B1/GPX8/PDIA4/GNAQ/ITPR2/ADCY7/HSPA5	3.1100977732923
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	17/498	170/9376	1.88273092369478	MAP3K1/ITGB1/CLDN4/TJP1/AMOT/MARVELD2/CCND1/SYNPO/MYH10/F11R/CGN/PRKCI/MARVELD3/RDX/AMOTL1/PARD6B/ROCK1	2.75080658710781
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	17/498	170/9376	1.88273092369478	EGFR/MET/LRP5/IGF1R/CDK6/SMARCA2/DVL3/CTNNB1/CCND1/FZD3/TCF7L2/GAB1/KRAS/TGFBR2/PIK3CB/FZD5/IGF2	2.75080658710781
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	20/498	212/9376	1.77616124876866	EGFR/MET/IGF1R/CDH1/FLT1/PDGFD/ITGB1/EFNA4/FGFR2/CTNND1/CTNNB1/PRKCI/RAPGEF1/GNAQ/KRAS/MAGI3/ADCY7/EFNA1/PIK3CB/PARD6B	2.70719840484755
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	15/498	144/9376	1.9611780455154	IGF1R/LIFR/IL6ST/BMPR1A/FGFR2/ZFHX3/DVL3/BMPR2/CTNNB1/FZD3/ACVR2A/KRAS/TBX3/PIK3CB/FZD5	2.75283340560405
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	10/498	80/9376	2.35341365461847	EGFR/MET/IGF1R/PDGFD/ERBB3/FGFR2/NF1/GAB1/KRAS/PIK3CB	2.87918936175198
Organismal Systems	Digestive system	hsa04970	Salivary secretion	11/498	93/9376	2.22688603877877	ADRB1/ATP2B1/TRPV6/ATP2B4/SLC9A1/SLC4A2/KCNN4/GNAQ/ITPR2/ADCY7/LYZ	2.81607529605929
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/498	26/9376	3.62063639172073	SLC19A3/SLC19A1/SLC5A6/SLC52A3/LMBRD1	3.16905936947906
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	15/498	148/9376	1.90817323347444	EGFR/LRP5/IGF1R/CDK6/JAG1/DVL3/CTNNB1/NOTCH3/NCOA3/CCND1/FZD3/TCF7L2/KRAS/PIK3CB/FZD5	2.63747591143837
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	13/498	122/9376	2.00618868918296	ITGAV/SLC9A1/MED12/SLC2A1/CTNNB1/NOTCH3/MED13/NCOA3/CCND1/RCAN1/SLC16A2/KRAS/PIK3CB	2.64933781266077
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/498	18/9376	4.18384649709951	GLB1/MANBA/HEXA/HEXB	3.20213466616017
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/498	73/9376	2.32117511140452	EGFR/MET/IGF1R/CDH1/CDK6/PDGFD/CCND1/KRAS/PIK3CB	2.68381788416652
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/498	28/9376	3.36201950659782	B4GALT1/B3GNT2/B3GNT3/B3GNT5/GCNT2	2.96446196742087
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	11/498	101/9376	2.0504990258062	CREB3L2/EDN1/DVL3/CTNNB1/FZD3/TCF7L2/GNAQ/KRAS/ADCY7/EDNRB/FZD5	2.51386598145263
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/498	52/9376	2.53444547420451	LRP2/LRP1/APOE/ABCA1/SORT1/NPC1/LRPAP1	2.62781470889691
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	11/498	103/9376	2.010683510742	COL14A1/COL4A2/COL4A1/DPP4/MME/COL21A1/COL5A2/SLC38A2/SLC7A8/KCNK5/KCNN4	2.44267901809126
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/498	78/9376	2.17238183503244	FN1/MET/CDH1/ITGB1/CLTC/CTNNB1/GAB1/WASL/PIK3CB	2.46243259070803
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	16/498	178/9376	1.69234240332115	LGR5/RNF43/LRP5/LGR4/TBL1X/ZNRF3/SERPINF1/TLE4/DVL3/NOTUM/CTNNB1/CCND1/FZD3/TCF7L2/PSEN1/FZD5	2.20865035322671
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	11/498	110/9376	1.88273092369478	FBN1/BMPR1A/BMP7/LTBP1/BMPR2/TFRC/ZFYVE16/ACVR2A/SMURF2/TGFBR2/ROCK1	2.20557217856044
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/498	14/9376	4.03442340791738	FUT8/B4GALT1/B3GNT2	2.69090656717816
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/498	59/9376	2.23374855353618	EGFR/CDH1/CTNNB1/CCND1/TCF7L2/KRAS/PIK3CB	2.25142432397821
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	14/498	155/9376	1.70053115688561	COLEC12/ITGB5/ITGAV/CANX/OLR1/ITGB1/CTSL/EEA1/ATP6V1B1/TFRC/DYNC1H1/LAMP1/CALR/RAB7B	2.08279742980645
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/498	36/9376	2.61490406068719	GALNT11/GALNT18/B3GNT3/GCNT4/C1GALT1	2.29914985102063
NA	NA	hsa03272	Virion - Hepatitis viruses	6/498	48/9376	2.35341365461847	EGFR/DPP4/HSPG2/CLDN4/TGOLN2/LAMP1	2.22638179936919
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	11/498	115/9376	1.80087305744718	EGFR/LRP5/CREB3L2/MMP15/MMP14/WNK2/GNA12/AKAP13/GNAQ/ITPR2/ADCY7	2.04656904458357
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/498	15/9376	3.76546184738956	GLB1/HEXA/HEXB	2.53860375095601
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	20/498	250/9376	1.50618473895582	EGFR/IGF1R/EEA1/EPN3/CLTC/FGFR2/FOLR1/TFRC/ZFYVE16/HSPA8/PRKCI/CYTH3/SMURF2/WWP1/RAB31/TGFBR2/WASL/PSD3/PARD6B/GIT2	1.92123972897844
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/498	37/9376	2.54423097796592	CDH1/CTNNB1/CCND1/TCF7L2/KRAS	2.22897744517606
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/498	89/9376	1.90388520373629	EGFR/ADRB1/PDGFD/GJA1/TJP1/GNAQ/ITPR2/KRAS/ADCY7	2.02914600336439
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/498	103/9376	1.82789410067454	FN1/LAMC1/LAMB1/LAMA5/COL4A2/COL4A1/LAMB2/GNAQ/PIK3CB/RAB7B	2.00090288149114
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/498	105/9376	1.7930770701855	ITGA6/DAG1/ITGB8/ADRB1/ITGB4/ITGB5/ITGAV/ITGB1/DMD/ADCY7	1.93548358225397
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	18/498	227/9376	1.49291438883286	EGFR/ITGAV/CDK6/CREB3L2/CTNNB1/CCND1/GNA12/AKAP13/GNAQ/TAPBPL/ITPR2/KRAS/ADCY7/PDIA3/GNG12/CALR/PIK3CB/ROCK1	1.78049332562645
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/498	41/9376	2.296013321579	EGFR/CDH1/RPS6KA5/CCND1/KRAS	1.9696405289239
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	13/498	155/9376	1.57906464567949	EGFR/CDK6/CREB3L2/DVL3/CTNNB1/CCND1/FZD3/TCF7L2/PBX1/GNAQ/ITPR2/ADCY7/FZD5	1.72165697964805
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	8/498	82/9376	1.8368106572632	CANX/LGMN/CTSL/HSPA8/TAPBPL/PDIA3/HSPA5/CALR	1.80250108122985
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	7/498	70/9376	1.88273092369478	MET/EPAS1/SLC2A1/GAB1/RAPGEF1/KRAS/PIK3CB	1.75565256824362
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	9/498	99/9376	1.71157356699525	EGFR/IGF1R/JAG1/NOTCH3/NCOA3/CCND1/KRAS/ADCY7/PIK3CB	1.68568477805555
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	9/498	99/9376	1.71157356699525	EGFR/PLPP3/PDGFD/SLC44A2/SLC22A5/SLC44A5/SLC44A1/KRAS/PIK3CB	1.68568477805555
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	9/498	99/9376	1.71157356699525	ITGA6/DAG1/ITGB8/ITGB4/ITGB5/ITGAV/ITGB1/DMD/EDN1	1.68568477805555
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	19/498	254/9376	1.40834202953546	EGFR/MET/ADRB1/ATP2B1/FLT1/ATP2B4/PDGFD/ASPH/MCOLN3/ERBB3/FGFR2/PHKA2/MYLK3/PHKB/GNAQ/P2RX4/ITPR2/ADCY7/EDNRB	1.56256699425341
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/498	160/9376	1.52971887550201	ITGA6/ITGB8/CDH1/NRCAM/ITGAV/PTPRF/PTPRM/ITGB1/GLG1/CLDN4/NLGN4X/CADM1/F11R	1.6005783787474
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	11/498	130/9376	1.59308001235712	EGFR/COL4A2/COL4A1/CREB3L2/EDN1/KRAS/ADCY7/EDNRB/GNG12/TGFBR2/PIK3CB	1.61268950165908
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/498	73/9376	1.80535841998129	EGFR/MET/CDK6/EML4/CCND1/KRAS/PIK3CB	1.63599458697954
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/498	61/9376	1.85186648232273	ATP2B1/TRPV6/ATP2B4/SLC40A1/ATP7B/TRPM7	1.58083942322483
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	10/498	120/9376	1.56894243641232	MAP3K1/PSEN2/RPS6KA5/SORT1/GAB1/MAGED1/PSEN1/RAPGEF1/KRAS/PIK3CB	1.4855593856241
NA	NA	hsa04382	Cornified envelope formation	16/498	217/9376	1.38818869949845	ITGA6/LAMA5/COL4A2/DST/ITGB4/COL4A1/PLEC/PRSS8/ST14/CLDN4/DSG2/KRT80/S100A11/TJP1/DSP/EPHX2	1.37022366910357
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/498	63/9376	1.7930770701855	GLI3/DVL3/CTNNB1/FZD3/TCF7L2/FZD5	1.49583470812677
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/498	49/9376	1.92115400377018	GALNT11/B4GALT1/GXYLT1/GALNT18/C1GALT1	1.53109463586262
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	21/498	300/9376	1.31791164658635	EGFR/MET/IGF1R/FLT1/MAP3K1/PDGFD/ERBB3/EFNA4/FGFR2/RASA1/TAOK1/RPS6KA5/NF1/MAP3K4/GNA12/HSPA8/KRAS/GNG12/EFNA1/TGFBR2/IGF2	1.3254475949222
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/498	23/9376	2.45573598742797	ENPEP/MME/LNPEP	1.65544138639394
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	8/498	93/9376	1.6195534827482	EGFR/MAP3K1/MMP14/MAP3K4/GNAQ/ITPR2/KRAS/ADCY7	1.42206301335971
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	11/498	140/9376	1.47928858290304	CDH1/SLC9A1/JAG1/NOTCH3/MYLK3/CCND1/GNAQ/ITPR2/KRAS/ADCY7/GNG12	1.35319965617999
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/498	12/9376	3.13788487282463	CD46/NPC1	1.75503981786994
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	11/498	142/9376	1.45845353243962	ITGAV/HSP90B1/CTSL/BMPR1A/GPC1/EDN1/BMPR2/CTNNB1/ACVR2A/ASS1/PIK3CB	1.30372892092231
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	22/498	323/9376	1.28235542790356	EGFR/MET/CDK6/TIMP3/ST14/DNMT3A/ERBB3/EFNA4/MDM4/RPS6KA5/BMPR2/NOTCH3/DICER1/CCND1/FZD3/TP63/ABCB1/KRAS/RDX/EFNA1/PIK3CB/ROCK1	1.22304906820969
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/498	39/9376	1.93100607558439	GLDC/MTR/AHCYL1/AHCYL2	1.37982458421308
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	8/498	101/9376	1.49127201876814	FN1/COL4A2/COL4A1/EDN1/CCND1/KRAS/TGFBR2/PIK3CB	1.17562414174826
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/498	71/9376	1.59104021720686	EGFR/MET/FGFR2/SLC2A1/KRAS/PIK3CB	1.18394290212835
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/498	134/9376	1.40502307738416	EDN1/PPP1R12B/MYLK3/GNA12/MYH10/GNAQ/ITPR2/ADCY7/CALD1/ROCK1	1.11838652413745
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/498	87/9376	1.51484097308775	EGFR/CTNNB1/CCND1/TCF7L2/KRAS/TGFBR2/PIK3CB	1.14259149387191
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/498	28/9376	2.01721170395869	HACD3/HADHA/HACD2	1.27665559102191
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	8/498	104/9376	1.44825455668829	PLPP3/LPCAT3/PLA2G15/GPD1L/CDS1/PISD/PLD3/GPAM	1.0886728953529
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	16/498	238/9376	1.26570146130741	EGFR/MET/IGF1R/FLT1/PDGFD/EFNA4/FGFR2/RASA1/NF1/GAB1/ABL2/KRAS/GNG12/EFNA1/PIK3CB/IGF2	0.983330667454773
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	10/498	138/9376	1.36429777079332	PTPRF/PHKA2/INPPL1/PHKB/SORBS1/PRKCI/RAPGEF1/KRAS/FASN/PIK3CB	1.02105660070195
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	10/498	139/9376	1.35448267891711	EGFR/CREB3L2/HSP90B1/NCOA3/HSPA8/GNAQ/ITPR2/KRAS/ADCY7/PIK3CB	0.99719406870415
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/498	75/9376	1.50618473895582	CDK6/MDM4/CCND1/RRM2B/SHISA5/PPP1R13L	1.0423596614406
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/498	16/9376	2.35341365461847	HEXA/HEXB	1.28320298135987
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/498	30/9376	1.88273092369478	SLC19A1/MTR/FOLR1	1.14688221808645
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/498	60/9376	1.56894243641232	IGF1R/GNA12/GNAQ/ITPR2/KRAS	1.04706092539044
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	8/498	108/9376	1.39461549903317	RANBP17/KPNB1/NUP58/TMEM33/IPO7/NUP210/EEF1A1/RANBP2	0.976867684694769
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/498	76/9376	1.4863665187064	SLC9A1/MYLK3/SLC4A2/GNAQ/ITPR2/ADCY7	1.00825812797965
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/498	76/9376	1.4863665187064	EGFR/IGF1R/CDK6/CCND1/KRAS/PIK3CB	1.00825812797965
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	11/498	158/9376	1.31076203548371	LRP5/IGF1R/CLIP1/SLC38A9/DVL3/ATP6V1B1/FZD3/KRAS/SKP2/PIK3CB/FZD5	0.932998376898341
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	9/498	125/9376	1.35556626506024	SMPD1/SGPP1/DEGS1/GNA12/ORMDL1/GNAQ/KRAS/PIK3CB/ROCK1	0.947815824076343
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	6/498	77/9376	1.4670630574245	EGFR/CDK6/CCND1/KRAS/TGFBR2/PIK3CB	0.974642838189721
NA	NA	hsa04981	Folate transport and metabolism	3/498	31/9376	1.82199766809172	SLC19A1/MTR/FOLR1	1.08568670294391
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	8/498	110/9376	1.3692588535962	EGFR/IGF1R/FLT1/EPAS1/EDN1/SLC2A1/TFRC/PIK3CB	0.92262209504344
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/498	62/9376	1.51833139007643	IGF1R/HSPA8/KRAS/ADCY7/PIK3CB	0.96979061645872
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/498	32/9376	1.76506024096386	GLB1/GAA/B4GALT1	1.02670800098083
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/498	79/9376	1.42992222052768	SLC6A4/SLC1A3/CLTC/ATP6V1B1/SYT1/SLC6A2	0.908813483153121
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/498	63/9376	1.49423089182125	HADHA/PLOD2/KMT2C/PLOD1/ASH1L	0.932176391938499
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/498	18/9376	2.09192324854975	MTR/LMBRD1	1.0981953087728
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/498	65/9376	1.44825455668829	CREB3L2/PBX1/GNAQ/ITPR2/ADCY7	0.858867100814396
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/498	65/9376	1.44825455668829	KCNN4/GNAQ/ITPR2/KRAS/PIK3CB	0.858867100814396
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	11/498	166/9376	1.2475927807616	ADRB1/ATP2B1/CREB3L2/ATP2B4/MYLK3/GNA12/GNAQ/ITPR2/ADCY7/EDNRB/ROCK1	0.762263185854355
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/498	116/9376	1.2984351197895	ARHGAP5/ITGB1/CLDN4/CTNND1/CTNNB1/F11R/PIK3CB/ROCK1	0.765977777357038
NA	NA	hsa04081	Hormone signaling	14/498	219/9376	1.20357227998753	ADRB1/IGF1R/ITGAV/PRLR/BMPR1A/SLC40A1/CSH1/GNA12/SLC16A2/GNAQ/ADCY7/GNG12/PIK3CB/IGF2	0.721949517163881
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/498	102/9376	1.29207024175132	ATP2B1/ATP2B4/SLC9A1/SLC4A2/GNAQ/ITPR2/ADCY7	0.702419548318892
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	10/498	154/9376	1.22255254785375	EGFR/PPP1R12B/MYLK3/CCND1/RCAN1/GNAQ/ITPR2/KRAS/ADCY7/ROCK1	0.659512621468551
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	9/498	137/9376	1.23683053381409	SPTAN1/CTSL/CTSC/CTSV/CTSO/CTSF/ITPR2/KRAS/PIK3CB	0.661345241610673
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	6/498	86/9376	1.31353320257775	EGFR/ERBB3/GAB1/ABL2/KRAS/PIK3CB	0.691779433616296
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/498	86/9376	1.31353320257775	CREB3L2/SLC2A1/PCLO/KCNN4/GNAQ/ADCY7	0.691779433616296
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/498	53/9376	1.42092899901493	ATP2B1/ATP2B4/CLTC/GNAQ	0.727799375346511
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	9/498	138/9376	1.22786799371399	FN1/ITGB1/GNAQ/PKN2/ARHGEF7/WASL/PIK3CB/ROCK1/GIT2	0.638670169635428
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/498	122/9376	1.23457765488182	CREB3L2/MAP3K1/CSH1/GNAQ/ITPR2/KRAS/ADCY7/PIK3CB	0.617652988713625
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/498	54/9376	1.39461549903317	MTR/DNMT3A/AHCYL1/AHCYL2	0.688746188629318
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/498	71/9376	1.32586684767238	EGFR/MET/TJP1/ATP6V1B1/F11R	0.652760556910844
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/498	38/9376	1.4863665187064	HEXA/HEXB/UXS1	0.711494051307729
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	9/498	142/9376	1.19328016290514	MAP3K1/UBR5/BIRC6/RPS27A/HERC4/CUL5/SMURF2/WWP1/SKP2	0.54964117492801
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/498	90/9376	1.25515394912985	SLC9A1/SLC2A1/HMGCR/SLC4A2/ABCB1/ADCY7	0.576039080900158
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/498	56/9376	1.34480780263913	LRP2/GLI3/CCND1/SMURF2	0.612922947569858
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/498	23/9376	1.63715732495198	B4GALT1/B4GAT1	0.724565865293448
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/498	23/9376	1.63715732495198	PCYOX1/HMGCR	0.724565865293448
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	12/498	196/9376	1.15269240226211	CDK6/IL6ST/RPS27A/CTNNB1/TLR3/CCND1/RCAN1/TCF7L2/ITPR2/KRAS/GNG12/PIK3CB	0.511642794237309
Organismal Systems	Immune system	hsa04611	Platelet activation	8/498	126/9376	1.195384713457	ITGB1/MYLK3/PRKCI/GNAQ/ITPR2/ADCY7/PIK3CB/ROCK1	0.522935021228543
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/498	57/9376	1.32121468329458	HACD3/HADHA/HACD2/FASN	0.576090748148566
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/498	112/9376	1.17670682730924	LAMC1/LAMB1/ITGA6/LAMA5/ITGB1/LAMB2/HSPA8	0.445559601417575
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/498	42/9376	1.34480780263913	LPCAT3/SLC40A1/TFRC	0.530408617079468
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	5/498	77/9376	1.22255254785375	CDK6/CCND1/KRAS/TGFBR2/PIK3CB	0.464411054221724
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	9/498	149/9376	1.13722002102369	EGFR/PLPP3/PDGFD/GNA12/GAB1/CYTH3/KRAS/ADCY7/PIK3CB	0.399873933383932
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	10/498	169/9376	1.1140419666833	IGF1R/CTSL/BIRC6/RPS27A/WDFY3/KRAS/LAMP1/PIK3CB/C9orf72/RAB7B	0.354316778143883
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/498	133/9376	1.13246972853821	EGFR/IGF1R/CCND1/KRAS/SGK3/TGFBR2/SKP2/PIK3CB	0.364400303104116
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	7/498	115/9376	1.14601012746639	CREB3L2/GNAQ/ITPR2/KRAS/ADCY7/GNG12/PIK3CB	0.37311756749679
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/498	116/9376	1.13613072981582	SLC1A3/SLC38A1/SLC38A2/GNAQ/ITPR2/ADCY7/GNG12	0.34939960795451
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/498	98/9376	1.15269240226211	ATP2B1/CREB3L2/ATP2B4/GNAQ/ITPR2/ADCY7	0.359870312295231
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/498	27/9376	1.39461549903317	HACD3/HACD2	0.486313337024697
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/498	45/9376	1.25515394912985	ABCA1/ABCB1/ABCA5	0.40633777285768
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	9/498	156/9376	1.08619091751622	EGFR/CDK6/CLDN4/CTNNB1/TLR3/CCND1/KRAS/MAVS/PIK3CB	0.257099411033296
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/498	12/9376	1.56894243641232	GGCX	0.467058185719929
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	12/498	217/9376	1.04114152462384	EGFR/ADRB1/CREB3L2/HSP90B1/JAG1/CCND1/PAQR7/KPNB1/KRAS/ADCY7/PIK3CB/EPHX2	0.145220844644445
NA	NA	hsa04082	Neuroactive ligand signaling	11/498	199/9376	1.04070553571068	ADRB1/SLC6A4/GABRE/SLC1A3/P2RY6/GNAQ/P2RX4/ADCY7/SLC6A2/GNG12/TAC3	0.137458748740453
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/498	68/9376	1.10748877864399	CCND1/TCF7L2/KRAS/PIK3CB	0.210684281989914
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/498	31/9376	1.21466511206115	GLDC/ACSS1	0.283527638578103
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/498	31/9376	1.21466511206115	SEC63/HSPA5	0.283527638578103
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/498	50/9376	1.12963855421687	AOC1/ALDH18A1/ALDH4A1	0.217677837731904
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/498	69/9376	1.09143821663465	ADRB1/EDN1/GNAQ/ITPR2	0.180546957738766
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/498	107/9376	1.05573696655782	CREB3L2/PHKA2/SLC2A1/PHKB/GNAQ/ITPR2	0.137328765447001
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/498	13/9376	1.44825455668829	PRKDC	0.383028964802011
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/498	32/9376	1.17670682730924	ACSS1/HADHA	0.237139905738355
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/498	51/9376	1.10748877864399	PDIA4/TJP1/ATP6V1B1	0.182291548962651
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/498	70/9376	1.0758462421113	DAG1/DMD/CCND1/ABL2	0.150849648720789
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/498	89/9376	1.05771400207572	GABRE/SLC38A1/SLC38A2/ADCY7/GNG12	0.129563064165696
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/498	109/9376	1.03636564607052	PTPRF/CREB3L2/SLC27A2/SLC2A1/SLC27A6/PIK3CB	0.0904435737048147
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/498	90/9376	1.04596162427488	IGF1R/CREB3L2/KRAS/ADCY7/PIK3CB	0.103763597993558
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/498	71/9376	1.0606934781379	PRLR/CCND1/KRAS/PIK3CB	0.121578211693341
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	12/498	224/9376	1.00860585197935	NRP1/CREB3L2/CANX/MAP3K1/SLC2A1/CCND1/TRRAP/KRAS/ADCY7/TGFBR2/CALR/PIK3CB	0.0308746906330789
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/498	91/9376	1.03446754049164	GABRE/PDE10A/PDE7A/ADCY7/GNG12	0.0782497170500506
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/498	168/9376	1.00860585197935	EGFR/CSF3R/LIFR/PRLR/IL6ST/CSH1/CCND1/IL4R/PIK3CB	0.0266568357937316
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/498	15/9376	1.25515394912985	TPK1	0.234223000741706
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/498	75/9376	1.00412315930388	MTR/ALDH18A1/PC/ASS1	0.00849060551474935
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/498	36/9376	1.04596162427488	AGL/GAA	0.0654358758372822
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/498	115/9376	0.982294394971189	APP/SLC6A4/GNAQ/ITPR2/KRAS/GNG12	-0.0452453017749039
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/498	154/9376	0.978042038283002	ADRB1/ATP2B1/CREB3L2/ATP2B4/SLC9A1/RPS6KA5/GNAQ/ADCY7	-0.0650702633321447
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/498	76/9376	0.990911012470936	OLR1/SLC27A2/SLC27A6/SORBS1	-0.0188418511530312
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/498	37/9376	1.01769239118637	ALDH4A1/ASS1	0.0255375921532086
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	8/498	157/9376	0.959353336914537	CDK6/ZFP36L1/CCND1/TRPM7/ITPR2/KRAS/TGFBR2/PIK3CB	-0.121639760297203
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/498	98/9376	0.960577001885091	INPPL1/CDS1/IP6K2/ITPR2/PIK3CB	-0.0929133763896974
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/498	17/9376	1.10748877864399	MTR	0.105054728438983
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/498	38/9376	0.990911012470936	KRAS/PIK3CB	-0.0132960644094881
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	6/498	119/9376	0.949276095980561	CREB3L2/MMP14/EDN1/JAG1/RPS6KA5/PIK3CB	-0.131884500905421
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/498	59/9376	0.957320808658362	ADRB1/ADCY7/PIK3CB	-0.0778837545453428
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/498	100/9376	0.94136546184739	ITGA6/CSF3R/MME/TFRC/IL4R	-0.139609791321199
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	10/498	200/9376	0.94136546184739	ITGB1/CLDN4/MYO6/TJP1/GNA12/MYH10/CYFIP1/CYTH3/WASL/ROCK1	-0.198510984541312
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/498	18/9376	1.04596162427488	FASN	0.0462256300791166
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/498	122/9376	0.925933241161367	IGF1R/CREB3L2/CCND1/HMGCR/FASN/PIK3CB	-0.195020940865234
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	8/498	163/9376	0.924039717150812	CREB3L2/HSPG2/MAP3K1/TLR3/KRAS/MAVS/TGFBR2/PIK3CB	-0.231698156889913
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/498	19/9376	0.990911012470936	GLDC	-0.0093921870354531
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	10/498	205/9376	0.9184053286316	CDK6/CREB3L2/SCIN/IL6ST/UBR4/CCND1/KRAS/SND1/SKP2/PIK3CB	-0.279751948832655
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	11/498	226/9376	0.916373458435512	ADRB1/ATP2B1/CREB3L2/ATP2B4/PDE10A/SLC9A1/GLI3/EDN1/ADCY7/PIK3CB/ROCK1	-0.301391186612985
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/498	42/9376	0.896538535092752	AOC1/HADHA	-0.159152003239042
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/498	20/9376	0.94136546184739	DHCR24	-0.0621678916713835
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/498	43/9376	0.875688801718502	PLPP3/ABCA1	-0.19349804741058
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	19/498	388/9376	0.921955864695897	LRP1/APOE/LRP5/APP/MME/PSEN2/SLC39A10/DVL3/CTNNB1/NCSTN/FZD3/RTN4/PSEN1/GNAQ/ITPR2/KRAS/PIK3CB/FZD5/UQCR10	-0.371849621137294
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/498	44/9376	0.855786783497627	CREB3L2/DYNC1H1	-0.227084125613466
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/498	67/9376	0.843013846430498	GNAQ/ITPR2/KRAS	-0.305414726505301
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/498	22/9376	0.855786783497627	AOC1	-0.160383785656152
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/498	90/9376	0.836769299419902	EGFR/EML4/KRAS/PIK3CB	-0.368511884913043
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/498	23/9376	0.818578662475991	ASS1	-0.206309655807041
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/498	47/9376	0.801162095189268	ACSS1/PC	-0.323648277451036
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/498	93/9376	0.809776741374099	JAG1/NOTCH3/IL4R/MAML2	-0.436620030239738
Human Diseases	Infectious disease: viral	hsa05162	Measles	6/498	136/9376	0.830616583982991	CDK6/CD46/CCND1/HSPA8/MAVS/PIK3CB	-0.471245368617068
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/498	50/9376	0.753092369477912	LRP1/MET	-0.414585918951594
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/498	51/9376	0.738325852429325	PLPP3/PLD3	-0.44377642285926
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/498	97/9376	0.776383886059703	RPS6KA5/GNAQ/ADCY7/GNG12	-0.524301517765862
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/498	27/9376	0.697307749516585	HADHA	-0.373029642233418
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/498	52/9376	0.724127278344146	IGF1R/ADCY7	-0.472445849616457
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/498	98/9376	0.768461601508073	PLPP3/SCIN/INPPL1/PIK3CB	-0.545697065074625
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	11/498	248/9376	0.835082264542039	AHNAK/HSP90B1/MYO6/CTNNB1/TCF7L2/CYFIP1/CYTH3/DYNC1H1/WASL/PIK3CB/RAB7B	-0.623373199240276
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/498	99/9376	0.760699363109002	GNAQ/ITPR2/ADCY7/PIK3CB	-0.566892110241703
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/498	28/9376	0.672403901319564	ATP6V1B1	-0.411150785377051
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/498	78/9376	0.724127278344146	INPPL1/IP6K2/PIK3CB	-0.57943407206911
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/498	103/9376	0.731157640269817	GNAQ/TGFBR2/CALR/PIK3CB	-0.649753938109612
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/498	56/9376	0.672403901319564	HSPA8/EEF1A1	-0.58232779211712
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/498	30/9376	0.627576974564926	PC	-0.483868112028586
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/498	30/9376	0.627576974564926	PGAP1	-0.483868112028586
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	9/498	214/9376	0.791802724918365	CUL5/GNAQ/TAPBPL/ITPR2/KRAS/PDIA3/GNG12/CALR/PIK3CB	-0.72967509493319
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/498	105/9376	0.717230828074202	RPS27A/SMURF2/KRAS/RAB7B	-0.690090673913847
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/498	31/9376	0.607332556030574	HADHA	-0.518631425787707
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/498	128/9376	0.735441767068273	PDE10A/ENTPD4/PDE7A/RRM2B/ADCY7	-0.713748312801992
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/498	83/9376	0.680505153142691	MTF2/TEX10/PHC1	-0.692416924517622
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/498	32/9376	0.588353413654618	BIRC6	-0.552428189504122
Human Diseases	Immune disease	hsa05310	Asthma	1/498	32/9376	0.588353413654618	PRG2	-0.552428189504122
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/498	59/9376	0.638213872438908	ENTPD4/RRM2B	-0.66021077417623
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/498	59/9376	0.638213872438908	GPX8/RRM2B	-0.66021077417623
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/498	60/9376	0.627576974564926	KRAS/PIK3CB	-0.685393763396756
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/498	110/9376	0.684629426798101	IGF1R/KRAS/ADCY7/PIK3CB	-0.78797801631256
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/498	34/9376	0.553744389321994	POLR2J3	-0.617370616723213
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	8/498	201/9376	0.749345641271554	SPINT1/MET/IGF1R/FLT1/FUT8/ASPSCR1/PBX1/TGFBR2	-0.850771616709693
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/498	87/9376	0.649217559894751	ASPH/SLC9A1/UQCR10	-0.778494823090889
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	7/498	180/9376	0.732173136992414	TLR3/TAPBPL/SRSF6/PDIA3/MAVS/CALR/PIK3CB	-0.859277905624325
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/498	158/9376	0.71496111026384	CDK6/CDKN1C/PRKDC/PDS5A/CCND1/SKP2	-0.85576998188598
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/498	88/9376	0.64184008762322	F5/CD46/SERPINE2	-0.799465905086352
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/498	63/9376	0.597692356728501	PTGES/EPHX2	-0.758798556626321
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	8/498	205/9376	0.73472426290528	CDK6/CCND1/TAPBPL/PDIA3/MAVS/SKP2/CALR/PIK3CB	-0.909512878545734
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/498	65/9376	0.579301822675317	PLPP3/GPAM	-0.806068378972463
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/498	37/9376	0.508846195593184	UXS1	-0.708942358854409
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/498	37/9376	0.508846195593184	GNAQ	-0.708942358854409
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/498	91/9376	0.620680524294982	INPPL1/KRAS/PIK3CB	-0.861147654347226
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/498	68/9376	0.553744389321994	RDH10/ALDH1A3	-0.874687052041642
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/498	144/9376	0.653726015171798	VLDLR/PUM2/GNAQ/ITPR2/PIK3CB	-0.991735711582517
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	3/498	95/9376	0.594546607482562	FLT1/CTSL/ATP6V1B1	-0.94069339386728
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/498	69/9376	0.545719108317327	KRAS/PIK3CB	-0.896988545608572
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/498	41/9376	0.4592026643158	GLDC	-0.821886883847695
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/498	41/9376	0.4592026643158	GABRE	-0.821886883847695
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	8/498	216/9376	0.697307749516585	VLDLR/OLR1/HSP90B1/ABCA1/HSPA8/KRAS/HSPA5/PIK3CB	-1.06591648846784
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/498	72/9376	0.522980812137439	MAP3K1/MAVS	-0.962298890937687
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/498	149/9376	0.631788900568718	GABRE/GNAQ/ITPR2/ADCY7/GNG12	-1.07300683636965
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/498	43/9376	0.437844400859251	HADHA	-0.875029862783082
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/498	75/9376	0.502061579651941	ATP7B/PIK3CB	-1.0253784504111
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	8/498	227/9376	0.66351750614794	SLC26A2/EGFR/MET/ABL2/KRAS/PIK3CB/EPHX2/UQCR10	-1.2154338523416
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/498	105/9376	0.537923121055651	ITPR2/KRAS/PIK3CB	-1.12768638327515
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/498	47/9376	0.400581047594634	PIK3CB	-0.975673685568979
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/498	78/9376	0.482751518896097	DHX36/DCP2	-1.08641184919863
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/498	78/9376	0.482751518896097	ITGB1/EEF1A1	-1.08641184919863
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/498	298/9376	0.69496779062559	CSF3R/LIFR/PRLR/IL6ST/BMPR1A/BMP7/CSH1/BMPR2/ACVR2A/IL4R/TGFBR2	-1.2673643379286
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	9/498	253/9376	0.669746178389447	EGFR/ITGB1/RPS27A/RPS6KA5/CYTH3/ITPR2/WASL/PIK3CB/ROCK1	-1.26119434348239
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/498	48/9376	0.392235609103079	HADHA	-0.999779759558469
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/498	48/9376	0.392235609103079	PIK3CB	-0.999779759558469
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/498	133/9376	0.566234864269107	CREB3L2/GNAQ/ITPR2/GNG12	-1.19320956327573
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/498	49/9376	0.384230800754036	CREB3L2	-1.02349977749229
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/498	109/9376	0.51818282303526	IL6ST/IL4R/TGFBR2	-1.19830862546896
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/498	83/9376	0.453670102095128	SLC27A2/EPHX2	-1.18401930860646
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/498	138/9376	0.545719108317327	IGF1R/SLK/ITPR2/ADCY7	-1.27326198569719
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/498	85/9376	0.442995511457595	ENTPD4/RRM2B	-1.22174245856141
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	6/498	193/9376	0.585304950371434	GNAQ/KRAS/ADCY7/GNG12/PIK3CB/ROCK1	-1.37866246767635
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/498	116/9376	0.486913169921064	GLDC/ACSS1/PC	-1.3169130696556
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/498	144/9376	0.522980812137439	CTNNB1/CCND1/TCF7L2/FASN	-1.36619262330117
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/498	117/9376	0.482751518896097	SMARCA2/BPTF/TRRAP	-1.33337667018881
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/498	94/9376	0.400581047594634	HSP90B1/USP25	-1.38329992797468
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/498	63/9376	0.298846178364251	POLR2J3	-1.32245687281459
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/498	66/9376	0.285262261165876	STS	-1.38002381284308
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/498	66/9376	0.285262261165876	IL4R	-1.38002381284308
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	5/498	187/9376	0.503403990292722	ANTXR2/TRPM7/ITPR2/PKN2/MAVS	-1.62454835334341
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/498	67/9376	0.281004615476833	ACSS1	-1.39879711509396
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/498	69/9376	0.272859554158664	CREB3L2	-1.43575629728224
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/498	70/9376	0.268961560527826	SLC2A1	-1.45395327080204
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/498	73/9376	0.257908345711614	RANBP2	-1.5074753045814
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/498	109/9376	0.34545521535684	TLR3/PIK3CB	-1.62789269186022
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/498	142/9376	0.397760054301714	ITPR2/TGFBR2/PIK3CB	-1.71262206305488
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/498	173/9376	0.435313508368735	CDK6/TLR3/MAVS/PIK3CB	-1.77545013179651
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/498	78/9376	0.241375759448049	ITGB1	-1.59338962632816
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	16/498	480/9376	0.627576974564926	LRP5/APP/GPX8/PSEN2/RPS27A/DVL3/CTNNB1/FZD3/PSEN1/GNAQ/ITPR2/KRAS/HSPA5/FZD5/C9orf72/UQCR10	-1.98382105213223
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/498	82/9376	0.2296013321579	RRM2B	-1.65944878893512
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/498	83/9376	0.226835051047564	MAVS	-1.6756216926953
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/498	122/9376	0.308644413720456	KRAS/PIK3CB	-1.82036880002295
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/498	86/9376	0.218922200429625	KCNK5	-1.7233694975672
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	7/498	275/9376	0.479240598758671	LAMC1/CREB3L2/HSPA8/ITPR2/HSPA5/PIK3CB/UQCR10	-2.07587714749864
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/498	191/9376	0.394289198679535	CREB3L2/SLC29A3/KRAS/GNG12	-2.00301942395574
Cellular Processes	Cell motility	hsa04814	Motor proteins	4/498	194/9376	0.388191943029851	MYO6/MYH10/MYO7A/DYNC1H1	-2.03934241498752
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2/498	133/9376	0.283117432134553	KRAS/PIK3CB	-1.97201449646566
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	3/498	168/9376	0.336201950659782	SMPD1/TLR3/TRPM7	-2.05613060088983
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	2/498	138/9376	0.272859554158664	ATP6V1B1/UQCR10	-2.03803484783024
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	4/498	205/9376	0.36736213145264	SLC2A1/TGFBR2/PIK3CB/UQCR10	-2.16903473797189
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	5/498	235/9376	0.400581047594634	CREB3L2/SMARCA2/KRAS/ADCY7/UQCR10	-2.2039933826122
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/498	100/9376	0.188273092369478	IL6ST	-1.93273500149595
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/498	103/9376	0.182789410067454	RNMT	-1.97508234790999
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/498	105/9376	0.17930770701855	PPP1R13L	-2.00287780199776
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	7/498	308/9376	0.427893391748813	CREB3L2/GPX8/SLC1A3/POLR2J3/CLTC/GNAQ/UQCR10	-2.4179054043903
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/498	154/9376	0.244510509570751	TPK1/GGCX	-2.23881891773423
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/498	370/9376	0.457961576033865	ADRB1/GABRE/PRLR/EDN1/CSH1/P2RY6/P2RX4/EDNRB/TAC3	-2.51946136969878
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	2/498	157/9376	0.239838334228634	PIK3CB/UQCR10	-2.27487020563372
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	5/498	268/9376	0.351255769346041	SLC39A10/RPS27A/ITPR2/HSPA5/UQCR10	-2.55194984056338
Genetic Information Processing	Transcription	hsa03040	Spliceosome	4/498	243/9376	0.309914555340704	SF1/SF3B1/HSPA8/SRSF6	-2.58132099984244
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	2/498	181/9376	0.208036566154119	EEA1/LAMP1	-2.5480696200019
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/498	195/9376	0.193100607558439	CLCN5/PIK3CB	-2.69671120507486
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	7/498	368/9376	0.358128164833246	GPX8/NUP58/NUP210/HSPA5/C9orf72/UQCR10/RANBP2	-2.97509459821413