category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
NA	NA	hsa04518	Integrin signaling	22/314	154/9376	4.26569608735214	FN1/FBN1/CDH1/ITGB4/MET/LAMA5/COL4A1/COL4A2/LAMB1/EGFR/LAMC1/FRAS1/ITGB8/ITGB5/ICAM3/FERMT1/ITGA6/ITGA4/FERMT2/ITGAM/ARHGEF6/ITGA3	7.60609947055922
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	27/314	233/9376	3.46015691205817	FN1/FBN1/FBN2/ITGB4/FBLN1/COL4A1/COL4A2/SYNE2/BGN/DSG2/DAG1/MYH10/HSPG2/ITGB8/ITGB5/COL5A2/ITGA6/ITGA4/ANK3/CAPZA2/DIAPH1/DIAPH3/DMD/FMNL2/FMNL1/ITGA3/COL3A1	7.07839577627984
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	15/314	89/9376	5.03256279968511	FN1/ITGB4/LAMA5/COL4A1/COL4A2/LAMB1/LAMC1/FRAS1/DAG1/HSPG2/ITGB8/ITGB5/ITGA6/ITGA4/ITGA3	7.11503192848904
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	24/314	238/9376	3.0110795910721	RPL39/RPS29/RPS27/RPL34/RPS28/RPL37/RPL37A/RPS15A/RPL36/EGFR/RPL21/RPL38/IL6ST/RPLP2/C5AR1/RPS24/NRP1/RPS21/TLR2/TNFRSF1A/RPS27A/IL6R/RPS17/NFKB1	5.8496595876139
NA	NA	hsa04517	IgSF CAM signaling	26/314	299/9376	2.59651066186652	CDH1/NRP2/PTPRF/MYH10/CADM1/ICAM3/LMO7/TJP1/ITGA4/ANK3/LCP2/CSK/DOK2/NRP1/JAM3/BCAR1/JAML/PLXNA1/ITGAM/TUBA1B/PARD3/NLGN4X/SORBS1/LYN/MPDZ/BAIAP2	5.22245471678162
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	21/314	232/9376	2.70283329672743	FN1/ITGB4/EGFR/MYH10/ITGB8/ITGB5/ITGA6/ITGA4/FGFR2/BCAR1/DIAPH1/NCKAP1L/ITGAM/DIAPH3/ARHGEF6/BAIAP2/ITGA3/APC/DOCK1/PPP1R12A/SLC9A1	4.88862191961681
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	19/314	203/9376	2.7947664020583	FN1/ITGB4/MET/LAMA5/COL4A1/COL4A2/LAMB1/EGFR/LAMC1/ITGB8/ITGB5/ITGA6/ITGA4/BCAR1/DIAPH1/CAPN2/ITGA3/DOCK1/PPP1R12A	4.81214479408419
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	27/314	362/9376	2.22711757046838	FN1/ITGB4/MET/LAMA5/COL4A1/COL4A2/LAMB1/EGFR/LAMC1/ITGB8/ITGB5/JAK2/ERBB3/ITGA6/CSF3R/ITGA4/FGFR2/PKN1/PRLR/TLR2/EIF4B/CDK6/EFNA5/IL6R/ITGA3/NFKB1/GNG2	4.43220782664224
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	16/314	160/9376	2.9859872611465	CDH1/PTPRF/CADM1/ITGB8/ICAM3/ITGA6/ITGA4/SELPLG/CLDN4/CDH3/JAM3/JAML/ITGAM/OCLN/NLGN4X/CD58	4.71632419138385
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/314	71/9376	4.20561586076971	MET/EGFR/TJP1/CSK/JAM3/ATP6V1C2/ATP6V1A/LYN/NFKB1/ATP6V1B1	5.04685581201342
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/314	86/9376	3.81928603169901	ITGB4/GJA1/DSG2/DAG1/ITGB8/ITGB5/ITGA6/ITGA4/SLC8A1/DMD/ITGA3	4.88898766522553
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	25/314	333/9376	2.24173217803791	FN1/ITGB4/LAMA5/COL4A1/COL4A2/LAMB1/EGFR/LAMC1/ITGB8/ITGB5/ITGA6/ITGA4/PARD3/RB1/TNFRSF1A/CDK6/ATP6V1C2/PRKACA/ATP6V1A/CASP8/ITGA3/APC/WNT4/NFKB1/ATP6V1B1	4.29469394727711
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	12/314	103/9376	3.47882011007359	FN1/LAMA5/COL4A1/COL4A2/LAMB1/LAMC1/PLCB2/ITGAM/TLR2/PRKACA/COL3A1/NFKB1	4.70860139113249
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	16/314	170/9376	2.81034095166729	MYH10/TJP1/CLDN4/AMOT/RUNX1/JAM3/OCLN/AMOTL1/TUBA1B/AMOTL2/PARD3/MARVELD2/MAP3K5/PRKACA/MPDZ/MARVELD3	4.43391929983861
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/314	17/9376	8.78231547396028	NRP2/PCDH11X/DAG1/MYH10/LAMP2	5.97801502583671
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/314	93/9376	3.53181288952811	FN1/LAMA5/COL4A1/COL4A2/LAMB1/LAMC1/ITGA6/RB1/CDK6/ITGA3/NFKB1	4.56738203043077
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	12/314	112/9376	3.1992720655141	LAMA5/LAMB1/LAMC1/JAK2/ITGA6/GNAI3/ALOX5/TLR2/TNFRSF1A/CASP8/NFKB1/LY96	4.35840043700768
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	16/314	184/9376	2.59651066186652	MET/SEMA6D/BMP7/PLXNB1/SEMA6A/EPHB4/GNAI3/SEMA3F/SEMA4C/NRP1/PLXNA1/PARD3/FES/EFNA5/SEMA7A/WNT4	4.07112240339597
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	11/314	103/9376	3.18891843423412	COL14A1/COL4A1/COL4A2/DPP4/MME/COL21A1/SLC7A7/COL5A2/KCNN4/SLC8A1/COL3A1	4.15792349861337
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/314	105/9376	3.1281771307249	ITGB4/ADRB1/DAG1/ITGB8/ITGB5/ITGA6/ITGA4/SLC8A1/DMD/PRKACA/ITGA3	4.08204289708744
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/314	93/9376	3.2107389904801	CDH1/MET/EGFR/PTPRF/LMO7/TJP1/PARD3/SORBS1/BAIAP2/PTPRJ	3.98816578462615
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	16/314	204/9376	2.34195079305608	FN1/MET/EGFR/TIMP3/HSPG2/ITGB5/ERBB3/ANK3/GPC1/TLR2/EIF4B/PRKACA/GPC3/WNT4/PPP1R12A/SLC9A1	3.60709919305475
NA	NA	hsa04519	Cadherin signaling	25/314	404/9376	1.84776439427382	CDH1/MET/DSC3/EGFR/GJA1/GABRE/TEAD1/PCDH11X/DSG2/FAT1/LRP5/TJP1/TMC5/CDH3/NCKAP1L/TAOK3/AMOTL1/AMOTL2/YAP1/LRP6/MPDZ/APC/WNT4/NFKB1/MYO7A	3.24234822529399
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/314	29/9376	5.14825389852844	TEAD1/RASSF6/FRMD6/YAP1/RASSF4	4.16453619436668
Genetic Information Processing	Translation	hsa03010	Ribosome	16/314	222/9376	2.15206289091639	RPL39/RPS29/RPS27/RPL34/RPS28/RPL37/RPL37A/RPS15A/RPL36/RPL21/RPL38/RPLP2/RPS24/RPS21/RPS27A/RPS17	3.23359522079109
NA	NA	hsa03272	Virion - Hepatitis viruses	6/314	48/9376	3.73248407643312	DPP4/EGFR/HSPG2/CLDN4/OCLN/LAMP2	3.53282742465991
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	9/314	99/9376	2.71453387376954	ITGB4/DAG1/ITGB8/ITGB5/ITGA6/ITGA4/SLC8A1/DMD/ITGA3	3.19226048538631
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	9/314	101/9376	2.6607807277543	FN1/COL4A1/COL4A2/JAK2/PLCB2/DIAPH1/PRKCD/COL3A1/NFKB1	3.12359311985452
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	13/314	178/9376	2.18077721319688	NOTUM/LGR5/RNF43/LGR4/ZNRF3/LRP5/TLE1/PLCB2/SERPINF1/PRKACA/LRP6/APC/WNT4	2.96053156139943
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	8/314	89/9376	2.68403349316539	EGFR/GJA1/ADRB1/PLCB2/TJP1/GNAI3/TUBA1B/PRKACA	2.97129956003471
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	9/314	109/9376	2.46549406883656	PTPRF/SLC27A2/SLC2A1/SLC27A6/RPS6KA1/PRKCD/TNFRSF1A/PYGL/NFKB1	2.86461436796349
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/314	73/9376	2.8632754558939	MET/EGFR/RASSF5/RB1/CDK6/STK4/KIF5B	2.97485235510129
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/314	115/9376	2.33685959567987	EGFR/LRP5/PLCB2/GNAI3/WNK2/MMP15/PRKACA/LRP6/MEF2A	2.68499949938339
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	11/314	155/9376	2.11908773371687	COLEC12/ITGB5/ITGAM/DYNC1LI1/TUBA1B/PLA2R1/TLR2/ATP6V1C2/ATP6V1A/LAMP2/ATP6V1B1	2.6150464463911
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	11/314	157/9376	2.09209298551665	CDH1/TEAD1/BMP7/DLG5/RASSF6/AMOT/FRMD6/PARD3/YAP1/APC/WNT4	2.56865613712879
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	10/314	138/9376	2.16375888488877	FN1/ITGA4/LCP2/RPS6KA1/SKAP2/BCAR1/PKN1/BAIAP2/NFKB1/DOCK1	2.56361029667133
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	11/314	168/9376	1.95511070670306	EGFR/JAK2/CSF3R/IL6ST/LIFR/PRLR/IL15/STAT6/IL6R/IL27RA/CSF2RB	2.32522044195753
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	13/314	212/9376	1.83102992428795	CDH1/MET/EGFR/PLCB2/GNAI3/LCP2/FGFR2/BCAR1/RASGRP2/ITGAM/PARD3/RASSF5/EFNA5	2.27814040084397
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/314	51/9376	2.92743849132009	TJP1/ATP6V1C2/PRKACA/ATP6V1A/ATP6V1B1	2.56909183457071
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	12/314	193/9376	1.85657239035015	JAK2/PLCB2/GNAI3/DOCK2/BCAR1/RASGRP2/PRKCD/PARD3/PRKACA/LYN/NFKB1/GNG2	2.23814834072865
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	10/314	150/9376	1.99065817409766	CDH1/MET/EGFR/LRP5/ABCB1/FGFR2/RB1/LRP6/APC/WNT4	2.27667566271753
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/314	109/9376	2.19155028341027	JAK2/IL6ST/RUNX1/AHR/STAT6/IL6R/IL27RA/NFKB1	2.32913399964686
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	9/314	130/9376	2.0672219500245	COL4A1/COL4A2/EGFR/PLCB2/GNAI3/PRKACA/COL3A1/NFKB1/GNG2	2.28080372666834
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/314	71/9376	2.52336951646183	MET/EGFR/SLC2A1/G6PD/FGFR2/PGAM1	2.3983616976968
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	10/314	155/9376	1.92644339428806	EGFR/PBX1/PLCB2/GNAI3/AHR/RB1/CDK6/PRKACA/APC/WNT4	2.16488165585456
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	12/314	200/9376	1.7915923566879	MYH10/TJP1/CLDN4/NCKAP1L/OCLN/TUBA1B/MYO6/TNFRSF1A/CASP8/BAIAP2/NFKB1/CYTH4	2.10633925146984
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/314	56/9376	2.66606005459509	LRP2/GLI3/GAS1/PRKACA/CSNK1G2	2.3276364126963
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/314	116/9376	2.05930155941138	ITGA4/GNAI3/CLDN4/JAM3/BCAR1/ITGAM/OCLN/RASSF5	2.13688694690774
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/314	100/9376	2.09019108280255	MME/ITGA6/CSF3R/ITGA4/ITGAM/IL6R/ITGA3	2.04014337197512
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/314	80/9376	2.23949044585987	MET/EGFR/JAK2/ERBB3/FGFR2/IL6R	2.07242371252835
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/314	26/9376	3.4453699167075	SLC19A3/SLC52A3/SLC19A1	2.32414846488174
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/314	170/9376	1.75646309479206	MET/EGFR/LRP5/ARID1A/RB1/CDK6/SMARCD3/LRP6/APC/WNT4	1.85274288388885
Organismal Systems	Immune system	hsa04611	Platelet activation	8/314	126/9376	1.89586492771206	PLCB2/GNAI3/LCP2/RASGRP2/PRKACA/LYN/COL3A1/PPP1R12A	1.88449666927131
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	12/314	217/9376	1.65123719510405	EGFR/ADRB1/JAK2/EPHX2/GNAI3/RPS6KA1/AHR/RB1/KLF5/PRKACA/CYP1B1/NFKB1	1.80668928069045
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/314	106/9376	1.9718783800024	SPINT1/EGFR/FOLR1/FGFR2/RB1/SLC19A1/NFKB1	1.87311059318153
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/314	28/9376	3.1992720655141	ATP6V1C2/ATP6V1A/ATP6V1B1	2.16938710879967
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/314	30/9376	2.9859872611465	FOLR1/SLC19A1/NFKB1	2.02797515818078
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	15/314	300/9376	1.49299363057325	MET/EGFR/ERBB3/RPS6KA1/FGFR2/RASGRP2/TAOK3/TNFRSF1A/EFNA5/MAP3K5/MAPKAPK3/MAP3K3/PRKACA/STK4/NFKB1	1.61544852954098
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	12/314	227/9376	1.57849546844749	EGFR/PLCB2/GNAI3/BCAR1/RB1/TNFRSF1A/CDK6/PRKACA/CASP8/IL6R/NFKB1/GNG2	1.64234544165778
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	9/314	158/9376	1.70087881964041	LRP5/RPS6KA1/EIF4B/TNFRSF1A/ATP6V1C2/ATP6V1A/LRP6/WNT4/ATP6V1B1	1.65383264731155
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	8/314	137/9376	1.74364219628993	CTSV/CAPN2/TUBA1B/TNFRSF1A/MAP3K5/CASP8/NFKB1/CSF2RB	1.63211312845507
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/314	93/9376	1.92644339428806	ADRB1/PLCB2/KCNN4/TRPV6/PRKACA/SLC9A1	1.67130080140766
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/314	52/9376	2.296913277805	APOE/LRP2/APOC1/VAPA	1.74562080469688
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/314	73/9376	2.04519675420993	CDH1/MET/EGFR/RB1/CDK6	1.66873127425701
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	8/314	140/9376	1.70627843494086	CDH1/PLCB2/GNAI3/SLC8A1/PRKACA/MEF2A/GNG2/SLC9A1	1.56724334733031
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/314	144/9376	1.65888181174805	JAK2/ID4/IL6ST/LIFR/ISL1/FGFR2/APC/WNT4	1.48313027631348
NA	NA	hsa04382	Cornified envelope formation	11/314	217/9376	1.51363409551205	ITGB4/LAMA5/COL4A1/COL4A2/DSG2/PRSS8/ITGA6/TJP1/EPHX2/CLDN4/OCLN	1.42494504542309
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/314	122/9376	1.71327137934635	PLCB2/SLC2A1/SLC16A2/PRKACA/DIO2/WNT4/SLC9A1	1.47607491248027
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/314	77/9376	1.93895276697824	EGFR/RB1/CDK6/ARHGEF6/NFKB1	1.53995992136772
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/314	56/9376	2.13284804367607	ITGAM/TLR2/CASP8/NFKB1	1.58269106160945
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/314	36/9376	2.48832271762208	AGL/PYGL/GYG1	1.66538004458912
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/314	36/9376	2.48832271762208	GALNT11/B3GNT3/GCNT4	1.66538004458912
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/314	78/9376	1.91409439817083	FN1/CDH1/MET/BCAR1/DOCK1	1.50897488382016
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/314	78/9376	1.91409439817083	JAK2/ITGA4/ITGAM/TLR2/NFKB1	1.50897488382016
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	10/314	196/9376	1.52346288834005	JAK2/IL6ST/RB1/TNFRSF1A/CDK6/RPS27A/LYN/CASP8/NFKB1/GNG2	1.37857699065629
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	12/314	248/9376	1.44483254571605	PKN1/NCKAP1L/DYNC1LI1/TUBA1B/TLR2/MYO6/TNFRSF1A/CASP8/NFKB1/CYTH4/KIF5B/LY96	1.32151778567591
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/314	103/9376	1.73941005503679	PLCB2/GNAI3/TLR2/TNFRSF1A/CASP8/NFKB1	1.40453403601774
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	11/314	227/9376	1.4469541794102	MET/EGFR/SLC26A2/EPHX2/NDUFV3/PRKCD/AHR/MAP3K5/CYP1B1/PTPRJ/NFKB1	1.26890044818193
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	12/314	253/9376	1.41627854283628	EGFR/PLCB2/BCAR1/DIAPH1/CAPN2/PRKCD/TNFRSF1A/RPS27A/UBE2D3/NFKB1/CYTH4/DOCK1	1.2494356174204
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/314	61/9376	1.95802443353869	TRPV6/ATP7B/SLC40A1/SLC8A1	1.39729629244485
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	8/314	156/9376	1.53127551853667	EGFR/CLDN4/OCLN/RB1/TNFRSF1A/CDK6/CASP8/NFKB1	1.24553253336396
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/314	41/9376	2.18486872766817	CDH1/EGFR/RB1	1.41528348139145
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/314	86/9376	1.73603910531773	PCLO/PLCB2/SLC2A1/KCNN4/PRKACA	1.27638205792601
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/314	42/9376	2.13284804367607	AOC1/KYNU/CYP1B1	1.36962236538978
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/314	22/9376	2.71453387376954	AOC1/CNDP2	1.49863945011968
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/314	23/9376	2.59651066186652	ENPEP/MME	1.4269169844611
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	5/314	90/9376	1.65888181174805	EGFR/JAK2/TLR2/MAP3K3/NFKB1	1.16910324916372
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/314	115/9376	1.55790639711991	PLCB2/GNAI3/SLC6A4/ALOX5/PRKACA/GNG2	1.12052036115876
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/314	91/9376	1.64065234128928	GABRE/PDE10A/GNAI3/PRKACA/GNG2	1.14311676207827
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/314	24/9376	2.48832271762208	EXTL2/HS6ST2	1.35890443468467
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	6/314	116/9376	1.54447616955853	GLDC/G6PD/PGAM1/ACSS1/ESD/GLUD1	1.0983501433515
NA	NA	hsa04081	Hormone signaling	10/314	219/9376	1.36346450280662	ADRB1/JAK2/PLCB2/SLC16A2/GNAI3/SLC40A1/PRLR/PRKACA/DIO2/GNG2	1.01308500254105
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/314	69/9376	1.73100710791101	LCP2/ALOX5/ALOX5AP/LYN	1.13443527294079
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/314	69/9376	1.73100710791101	ADRB1/PLCB2/GNAI3/PRKACA	1.13443527294079
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/314	93/9376	1.60536949524005	EGFR/PLCB2/PRKCD/MAP3K3/PRKACA	1.09208455560304
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/314	168/9376	1.42189869578405	JAK2/CAPN2/STAT6/TNFRSF1A/PYGL/CASP8/CYLD/GLUD1	1.02711388846076
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/314	194/9376	1.38525182218136	MYH10/CAPZA2/DYNC1LI1/TUBA1B/MYO6/KIFC3/KIF5B/MYO7A/DNAH14	1.00928857145646
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/314	70/9376	1.70627843494086	JAK2/SLC2A1/TNFRSF1A/NFKB1	1.10403254337309
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	6/314	119/9376	1.50553979553605	IL15/TNFRSF1A/MAP3K5/CASP8/CYLD/NFKB1	1.03307566291415
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	5/314	95/9376	1.57157224270868	IL15/TLR2/ATP6V1C2/ATP6V1A/ATP6V1B1	1.04225498164023
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/314	120/9376	1.49299363057325	MAGED1/RPS6KA1/PRKCD/MAP3K5/MAP3K3/NFKB1	1.01171617087072
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	11/314	250/9376	1.31383439490446	MCOLN3/CTSV/AP1S3/ATP6V1C2/ATP6V1A/BLOC1S6/LAMP2/ATP6V1B1/SLC11A1/VPS13C/AP1M2	0.936200231334993
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/314	49/9376	1.82815546600806	GNAI3/PRKACA/NFKB1	1.08187567851001
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	7/314	148/9376	1.41229127216388	EGFR/LRP5/RB1/CDK6/LRP6/APC/WNT4	0.941065038751475
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/314	50/9376	1.7915923566879	AOC1/SMS/CNDP2	1.04466566765309
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/314	75/9376	1.59252653927813	LRP2/PLCB2/GPX8/PRKACA	0.958985520705471
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/314	76/9376	1.57157224270868	SLC27A2/SLC27A6/SORBS1/FABP5	0.931268439699555
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/314	76/9376	1.57157224270868	PLCB2/GNAI3/PRKACA/SLC9A1	0.931268439699555
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/314	52/9376	1.72268495835375	ALOX5/PRKACA/CYP1B1	0.97272031995765
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/314	77/9376	1.5511622135826	RUNX1/RB1/CDK6/NFKB1	0.903951454151449
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/314	181/9376	1.31977337509237	JAK2/ITGAM/PLA2R1/TLR2/TNFRSF1A/CASP8/LAMP2/NFKB1	0.808619396711339
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/314	53/9376	1.69018146857349	PLCB2/SLC8A1/PRKACA	0.937911412266604
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/314	78/9376	1.53127551853667	GNAI3/ITGAM/NFKB1/LY96	0.87702256513614
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/314	79/9376	1.51189228412481	SLC6A4/ATP6V1C2/ATP6V1A/ATP6V1B1	0.85047029022935
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	7/314	157/9376	1.33133189987423	ITGB5/PBX1/JAK2/SLC2A1/BCAR1/ALOX5/DOCK1	0.779308840296104
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/314	105/9376	1.42189869578405	TNFRSF1A/LYN/CYLD/NFKB1/LY96	0.80924118089226
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	10/314	238/9376	1.25461649628004	MET/EGFR/FGFR2/RASGRP2/RASSF5/EFNA5/PRKACA/STK4/NFKB1/GNG2	0.740607102394787
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/314	31/9376	1.92644339428806	DPYD/CNDP2	0.961719709194208
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/314	31/9376	1.92644339428806	GLDC/ACSS1	0.961719709194208
NA	NA	hsa04981	Folate transport and metabolism	2/314	31/9376	1.92644339428806	FOLR1/SLC19A1	0.961719709194208
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/314	133/9376	1.34706192232173	PLCB2/GNAI3/COMT/PRKACA/GNG2/KIF5B	0.750351483006514
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/314	107/9376	1.39532115006846	PLCB2/SLC2A1/PGAM1/PRKACA/PYGL	0.765533025659106
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	9/314	214/9376	1.25578903506161	GNAI3/WEE1/AP1S3/TLR2/TNFRSF1A/CASP8/NFKB1/GNG2/AP1M2	0.704582901740741
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/314	32/9376	1.86624203821656	TNFRSF1A/CASP8	0.913663474650702
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/314	134/9376	1.33700922140888	MYH10/PLCB2/PRKCD/PRKACA/CALD1/PPP1R12A	0.731391038586676
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	9/314	216/9376	1.24416135881104	JAK2/PLCB2/TLR2/TNFRSF1A/MAP3K5/LYN/CASP8/NFKB1/LY96	0.675763149506843
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/314	163/9376	1.28232581767027	HSPG2/JAK2/TLR2/STAT6/RB1/CASP8/NFKB1	0.676834198975471
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	5/314	110/9376	1.35726693688477	EGFR/SLC2A1/EPAS1/IL6R/NFKB1	0.701586872731244
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/314	59/9376	1.51829860736263	GPX8/G6PD/SMS	0.743372401328958
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/314	59/9376	1.51829860736263	ADRB1/GNAI3/PRKACA	0.743372401328958
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/314	59/9376	1.51829860736263	CDH1/EGFR/APC	0.743372401328958
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	15/314	388/9376	1.15437651848447	APOE/MME/LRP5/PLCB2/NDUFV3/CAPN2/TUBA1B/TNFRSF1A/MAP3K5/CASP8/LRP6/APC/WNT4/NFKB1/KIF5B	0.578101380794078
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/314	60/9376	1.49299363057325	PLCB2/GNAI3/LYN	0.713083893081352
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	10/314	250/9376	1.1943949044586	EGFR/FOLR1/CAPZA2/EPN2/FGFR2/ARAP1/PARD3/VPS28/CYTH4/KIF5B	0.579899964692807
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	6/314	142/9376	1.26168475823091	LCP2/FOSL2/LILRA2/TNFRSF1A/CYLD/NFKB1	0.584879094315324
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/314	88/9376	1.35726693688477	SERPINE2/F5/C5AR1/ITGAM	0.626774750227308
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/314	115/9376	1.29825533093326	JAK2/PLCB2/GNAI3/PRKACA/GNG2	0.599027315083878
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	10/314	254/9376	1.17558553588445	MET/EGFR/MCOLN3/ADRB1/ERBB3/PLCB2/FGFR2/SLC8A1/PRKACA/ASPH	0.528079118837324
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/314	89/9376	1.3420167465827	GABRE/GNAI3/PRKACA/GNG2	0.603452492346516
NA	NA	hsa04082	Neuroactive ligand signaling	8/314	199/9376	1.20039688890311	GABRE/ADRB1/PLCB2/GNAI3/SLC6A4/PRKACA/P2RY13/GNG2	0.531870105197981
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	6/314	144/9376	1.24416135881104	C5AR1/TNFRSF1A/MAP3K5/CASP8/NFKB1/LY96	0.549602519149465
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/314	63/9376	1.42189869578405	GLI3/APC/WNT4	0.625420466865679
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/314	90/9376	1.32710544939844	ABCB1/SLC2A1/PRKACA/SLC9A1	0.580407649584824
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/314	13/9376	2.296913277805	XRCC6	0.870990733104117
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	8/314	201/9376	1.18845264125234	MET/SPINT1/PBX1/RUNX1/ITGAM/HHEX/NFKB1/JMJD1C	0.502730986332746
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/314	65/9376	1.378147966683	PBX1/PLCB2/PRKACA	0.569454091694545
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	8/314	205/9376	1.16526332142302	TLR2/RB1/CDK6/LYN/CASP8/CIR1/NFKB1/CD58	0.445331580441938
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	8/314	205/9376	1.16526332142302	IL6ST/RB1/CDK6/PRKACA/LYN/CASP8/NFKB1/GTF2A2	0.445331580441938
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/314	66/9376	1.35726693688477	HSD17B11/COMT/CYP1B1	0.54216114154648
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/314	66/9376	1.35726693688477	TLR2/STAT6/NFKB1	0.54216114154648
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/314	149/9376	1.20241097764288	GABRE/PLCB2/GNAI3/NDUFV3/PRKACA/GNG2	0.463591398809916
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/314	122/9376	1.22376527096168	JAK2/PLCB2/GNAI3/BCAR1/PRKACA	0.463069614616487
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/314	67/9376	1.33700922140888	PLCB2/RPS6KA1/PRKACA	0.51530707345418
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/314	68/9376	1.31734732109404	RUNX1/ITGAM/NFKB1	0.48887692484685
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/314	41/9376	1.45657915177878	GLDC/PGAM1	0.545367530065489
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/314	125/9376	1.1943949044586	PLCB2/GNAI3/TNFRSF1A/MAP3K5/NFKB1	0.407271458809461
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/314	97/9376	1.2313349530501	PLCB2/GNAI3/PRKACA/GNG2	0.426299643628487
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	6/314	154/9376	1.16337166018695	ADRB1/PLCB2/GNAI3/SLC8A1/PRKACA/SLC9A1	0.380507268531484
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/314	98/9376	1.21877031067204	PLPP3/PRKCD/LYN/DOCK1	0.405240339578239
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/314	70/9376	1.27970882620564	MET/SLC2A1/EPAS1	0.437232161598669
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/314	70/9376	1.27970882620564	DAG1/DMD/CASP8	0.437232161598669
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/314	71/9376	1.26168475823091	JAK2/PRLR/NFKB1	0.411991111959341
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	6/314	157/9376	1.14114162846363	CAPN2/RASSF5/RB1/MYBL2/CDK6/NFKB1	0.331972016087932
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	6/314	157/9376	1.14114162846363	NDUFV3/TNFRSF1A/MAP3K5/CASP8/IL6R/NFKB1	0.331972016087932
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/314	72/9376	1.24416135881104	CASP8/CYLD/NFKB1	0.387121029358316
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/314	44/9376	1.35726693688477	DYNC1LI1/PRKACA	0.442150614530326
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/314	101/9376	1.18256921233525	PLCB2/GNAI3/PRKACA/WNT4	0.343375814770414
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/314	17/9376	1.75646309479206	CDO1	0.581079983494503
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/314	17/9376	1.75646309479206	GLUD1	0.581079983494503
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/314	75/9376	1.1943949044586	ATP7B/MAP3K5/CASP8	0.314622023347402
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/314	75/9376	1.1943949044586	ZNF385A/CDK6/CASP8	0.314622023347402
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/314	105/9376	1.13751895662724	PRKCD/CASP8/CYLD/NFKB1	0.263774228193063
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/314	76/9376	1.17867918203151	EGFR/RB1/CDK6	0.291123799624553
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/314	19/9376	1.57157224270868	GLDC	0.464213802286919
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	8/314	224/9376	1.06642402183803	SLC2A1/NRP1/IL15/RB1/TNFRSF1A/MAP3K3/PRKACA/NFKB1	0.187296475263401
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	6/314	166/9376	1.07927250402885	ADRB1/PLCB2/GNAI3/SLC8A1/MEF2A/PPP1R12A	0.191816180512538
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	8/314	226/9376	1.0569866411138	ADRB1/PDE10A/GLI3/GNAI3/PRKACA/NFKB1/PPP1R12A/SLC9A1	0.161419190691702
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	5/314	138/9376	1.08187944244438	NDUFV3/ATP6V1C2/ATP6V1A/COX17/ATP6V1B1	0.180369820984173
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/314	138/9376	1.08187944244438	PTPRF/SORBS1/PRKACA/PYGL/RHOQ	0.180369820984173
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/314	20/9376	1.49299363057325	DHCR24	0.410818159757843
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	4/314	109/9376	1.09577514170514	TLR2/CASP8/NFKB1/LY96	0.187212526380325
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/314	139/9376	1.07409613710306	EGFR/PLCB2/GNAI3/PRKCD/PRKACA	0.163823397665592
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/314	50/9376	1.1943949044586	ITGA4/IL15	0.25654325858362
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/314	50/9376	1.1943949044586	MET/TLR2	0.25654325858362
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/314	110/9376	1.08581354950782	FBN1/LTBP1/BMP7/ID4	0.168517300711135
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/314	21/9376	1.42189869578405	CHPF	0.360275199728204
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/314	21/9376	1.42189869578405	DPYD	0.360275199728204
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	5/314	142/9376	1.05140396519243	GPC1/TNFRSF1A/MAP3K5/NFKB1/MEF2A	0.114890545438012
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	7/314	205/9376	1.01960540624515	PLCB2/SLC2A1/G6PD/NDUFV3/PRKCD/COL3A1/NFKB1	0.0528302739723375
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/314	23/9376	1.29825533093326	GLUD1	0.266572349048501
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/314	23/9376	1.29825533093326	B4GAT1	0.266572349048501
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/314	23/9376	1.29825533093326	GLUD1	0.266572349048501
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	10/314	298/9376	1.00200914803574	BMP7/CSF3R/IL6ST/LIFR/PRLR/IL15/TNFRSF1A/IL6R/IL27RA/CSF2RB	0.00656089992281272
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/314	54/9376	1.10592120783204	SMS/CDO1	0.145299355649864
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	16/314	480/9376	0.995329087048832	LRP5/PLCB2/GPX8/NDUFV3/CAPN2/TUBA1B/TNFRSF1A/MAP3K5/RPS27A/CASP8/LRP6/APC/WNT4/NFKB1/KIF5B/DNAH14	-0.0195552529766181
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/314	116/9376	1.02965077970569	PLCB2/GNAI3/PRKACA/GNG2	0.0598133397952612
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/314	87/9376	1.02965077970569	SLC8A1/ASPH/SLC9A1	0.0517189496589529
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/314	26/9376	1.1484566389025	HHEX	0.141097372241869
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/314	154/9376	0.969476383489122	EGFR/PLCB2/GNAI3/PRKACA/PPP1R12A	-0.0710922440952494
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/314	91/9376	0.98439140477357	LILRA2/LYN/NFKB1	-0.0278504356979628
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/314	187/9376	0.958070778977486	PLCB2/PKN1/PRKCD/CASP8/NFKB1/NLRP12	-0.107805744914848
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/314	27/9376	1.10592120783204	HACD3	0.102593692248587
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/314	93/9376	0.963221697144031	JAK2/STAT6/NFKB1	-0.0663479360062036
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/314	28/9376	1.06642402183803	HACD3	0.0655214145396672
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/314	28/9376	1.06642402183803	B3GNT3	0.0655214145396672
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/314	28/9376	1.06642402183803	MOCS1	0.0655214145396672
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/314	62/9376	0.963221697144031	TLE1/CIR1	-0.0540826353699555
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/314	63/9376	0.947932463856031	EPHX2/ALOX5	-0.0771846490380601
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/314	195/9376	0.918765311121999	PLCB2/SELPLG/C5AR1/ITGAM/TLR2/NFKB1	-0.213379290529768
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/314	65/9376	0.918765311121999	PLCB2/KCNN4	-0.122331547555008
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	10/314	323/9376	0.924454260416872	MET/EGFR/TIMP3/ABCB1/ERBB3/CDK6/EFNA5/CYP1B1/APC/NFKB1	-0.257189605055879
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/314	99/9376	0.904844624589847	EGFR/RB1/PRKACA	-0.177168121050934
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/314	99/9376	0.904844624589847	PLCB2/PRKCD/PRKACA	-0.177168121050934
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/314	99/9376	0.904844624589847	SELPLG/C5AR1/ITGAM	-0.177168121050934
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/314	31/9376	0.963221697144031	G6PD	-0.0381787154459444
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/314	31/9376	0.963221697144031	OXA1L	-0.0381787154459444
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/314	100/9376	0.895796178343949	IL6ST/TNFRSF1A/IL6R	-0.195003187459178
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/314	67/9376	0.891339480939253	PGAM1/ACSS1	-0.166148373754056
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/314	32/9376	0.93312101910828	ACSS1	-0.0705401947340615
Human Diseases	Immune disease	hsa05310	Asthma	1/314	32/9376	0.93312101910828	PRG2	-0.0705401947340615
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/314	136/9376	0.878231547396028	TLR2/CDK6/CASP8/NFKB1	-0.266260466811071
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	5/314	169/9376	0.883428183771153	VMP1/PRKCD/PRKACA/RPS27A/LAMP2	-0.284653335427618
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/314	33/9376	0.904844624589847	VTI1B	-0.101926134900564
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	7/314	235/9376	0.889443013958531	RPS6KA1/NDUFV3/ARID1A/MAP3K5/SMARCD3/PRKACA/COX17	-0.319493259897402
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/314	104/9376	0.861342479176874	PLPP3/CDS1/MBOAT7	-0.264674329951436
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/314	70/9376	0.853139217470428	SULT1A1/CYP1B1	-0.229568220175749
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/314	34/9376	0.878231547396028	POLR2J	-0.1324014518986
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	5/314	173/9376	0.863002098597253	JAK2/TNFRSF1A/CDK6/CASP8/NFKB1	-0.338540544478069
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	5/314	174/9376	0.858042316421407	HERPUD1/TUSC3/CAPN2/MAP3K5/UBE2D3	-0.35182836253028
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	9/314	308/9376	0.87252874514021	PLCB2/GPX8/NDUFV3/TUBA1B/MAP3K5/CASP8/KIF5B/POLR2J/DNAH14	-0.42341895597139
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/314	37/9376	0.807023584093648	GLUD1	-0.218923984448823
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/314	37/9376	0.807023584093648	COMT	-0.218923984448823
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/314	37/9376	0.807023584093648	PLCB2	-0.218923984448823
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/314	37/9376	0.807023584093648	CDH1	-0.218923984448823
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/314	110/9376	0.814360162130863	GNAI3/RPS6KA1/PRKACA	-0.364552271308974
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	5/314	180/9376	0.829440905874027	JAK2/TLR2/TNFRSF1A/CASP8/NFKB1	-0.430080830122721
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/314	39/9376	0.765637759268333	GLDC	-0.272995003898841
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/314	149/9376	0.80160731842859	EGFR/PLPP3/PLCB2/CYTH4	-0.454388105992993
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/314	78/9376	0.765637759268333	PLCB2/ISYNA1	-0.386882072231897
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/314	41/9376	0.728289575889389	XRCC2	-0.324548421260476
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/314	41/9376	0.728289575889389	GABRE	-0.324548421260476
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/314	42/9376	0.710949347892023	SLC40A1	-0.349464555345771
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/314	82/9376	0.728289575889389	DPYD/TPMT	-0.459992049904588
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/314	43/9376	0.694415642127092	PLPP3	-0.373846352882764
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/314	83/9376	0.719515002685903	SLC27A2/EPHX2	-0.477759297478231
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/314	83/9376	0.719515002685903	CASP8/NFKB1	-0.477759297478231
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/314	44/9376	0.678633468442386	TUSC3	-0.39772056898595
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/314	44/9376	0.678633468442386	GTF2A2	-0.39772056898595
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/314	158/9376	0.755946142062404	ORC6/WEE1/RB1/CDK6	-0.575883058025087
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/314	45/9376	0.663552724699222	ABCB1	-0.42111199397632
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/314	86/9376	0.694415642127092	EGFR/ERBB3	-0.529920745723757
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/314	86/9376	0.694415642127092	PLCB2/PRKACA	-0.529920745723757
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/314	87/9376	0.686433853137126	EGFR/APC	-0.54694385528221
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/314	47/9376	0.635316438541808	ACSS1	-0.466536904174327
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/314	47/9376	0.635316438541808	PRKCD	-0.466536904174327
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	7/314	268/9376	0.779922045821846	GNAI3/NDUFV3/TUBA1B/MAP3K5/PRKACA/RPS27A/KIF5B	-0.680410269126757
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/314	48/9376	0.62208067940552	PLCB2	-0.488611718406732
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/314	90/9376	0.663552724699222	PRKACA/NFKB1	-0.596983549572967
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/314	49/9376	0.60938515533602	GALNT11	-0.510286676176828
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/314	51/9376	0.585487698264019	PLPP3	-0.552505397456112
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/314	94/9376	0.635316438541808	CASP8/NFKB1	-0.661451134213509
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/314	54/9376	0.552960603916018	RMI2	-0.61323447429063
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/314	98/9376	0.60938515533602	CDS1/PLCB2	-0.723557469062751
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/314	98/9376	0.60938515533602	PLCB2/PRKACA	-0.723557469062751
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/314	55/9376	0.542906774753908	PLPP3	-0.632839106322265
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/314	99/9376	0.603229749726565	EGFR/PLPP3	-0.738739555457141
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/314	56/9376	0.533212010919017	TUSC3	-0.652144991651122
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/314	57/9376	0.523857414236227	HACD3	-0.671163347393365
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	3/314	142/9376	0.630842379115457	RPS27A/UBE2D3/RHOBTB1	-0.825086552316613
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/314	102/9376	0.585487698264019	PLCB2/SLC9A1	-0.783506127589206
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/314	103/9376	0.579803351678931	MSI2/WDR82	-0.798177534058757
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/314	59/9376	0.506099535787542	DPYD	-0.70837924100812
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/314	60/9376	0.497664543524416	MAPKAPK3	-0.726596249367131
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/314	62/9376	0.481610848572016	PRKACA	-0.762293234851384
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/314	63/9376	0.473966231928015	POLR2J	-0.7797897649418
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/314	65/9376	0.459382655560999	PLPP3	-0.814117186804562
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	6/314	275/9376	0.65148812970469	LAMC1/NDUFV3/PRKCD/TUBA1B/PRKACA/KIF5B	-1.09188725761294
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/314	69/9376	0.432751776977753	PRKACA	-0.880301143101551
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/314	117/9376	0.510425172845555	ARID1A/SMARCD3	-0.991901167400912
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/314	122/9376	0.489506108384672	LCP2/NFKB1	-1.05643833217919
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/314	75/9376	0.398131634819533	PGAM1	-0.974104971368737
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/314	78/9376	0.382818879634166	LSM3	-1.01883439091592
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	8/314	368/9376	0.64912766546663	GPX8/NDUFV3/ANXA11/TUBA1B/TNFRSF1A/MAP3K5/KIF5B/DNAH14	-1.27819548855538
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/314	79/9376	0.377973071031202	CYP1B1	-1.03345066768301
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/314	133/9376	0.449020640773909	EGFR/STK4	-1.19122310086794
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2/314	133/9376	0.449020640773909	LCP2/SH3BP2	-1.19122310086794
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/314	83/9376	0.359757501342951	UBE2D3	-1.09054605167192
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/314	138/9376	0.432751776977753	RPS6KA1/PRKACA	-1.24957446442812
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/314	144/9376	0.414720452937013	PLCB2/MAP3K5	-1.31745299517857
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/314	191/9376	0.469003234735052	GNAI3/PRKACA/GNG2	-1.38009000964162
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/314	154/9376	0.387790553395649	KYNU/MOCS1	-1.42589078197545
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/314	105/9376	0.284379739156809	RPS27A	-1.37262662990453
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/314	108/9376	0.276480301958009	RANBP17	-1.40769204997434
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/314	128/9376	0.23328025477707	PDE10A	-1.62575895671465
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/314	370/9376	0.403511792046824	GABRE/ADRB1/C5AR1/PRLR/P2RY13	-2.1790900943983
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/314	243/9376	0.245760268407119	LSM3/PRPF40A	-2.21740104357396
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/314	449/9376	0.133006114082249	SLC8A1/PRKACA	-3.50449037265637