category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	41/996	174/9376	2.21815999630707	RRBP1/LMAN1/RPN2/HSPA8/SEC62/P4HB/HSP90B1/SIL1/NFE2L2/CKAP4/GANAB/MAN1A2/UBXN4/TUSC3/BCL2/ERP29/HSPA4L/ERO1B/PDIA3/SEL1L/EDEM3/BAG2/PDIA4/UBE2G2/UGGT2/UBE4B/MBTPS1/ERLEC1/DNAJB1/SVIP/SEC63/MAPK8/DDIT3/ATF6/HSPH1/DDOST/MAN1C1/PRKCSH/AMFR/SEC31A/MOGS	5.59153620371407
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	25/996	93/9376	2.53055231679406	MET/EGFR/CDH1/CTNND1/PTPRF/SORBS1/ROCK1/IQGAP1/TCF7L2/IGF1R/TJP1/WASF2/SMURF2/LMO7/ROCK2/PARD3/ARHGAP29/KRIT1/BAIAP2/TGFBR2/EP300/PTPN1/SMAD4/ACTN4/WASL	5.11374156600152
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	47/996	250/9376	1.76976706827309	CTSC/GNS/PSAP/LGMN/GAA/CTSL/SLC29A3/CLTC/SLC38A9/HEXA/HGSNAT/ATP6V1B1/ASAH1/TFEB/VPS13C/AP1S3/CTSA/GLB1/CTSV/SLC17A5/AP2A2/MANBA/MCOLN3/GUSB/CTSO/GNPTAB/CLN5/LIPA/CTSF/CTBS/DMXL1/NAGLU/SLC11A2/ATP6V1H/FUCA2/FUCA1/SLC29A1/AP2A1/VPS13A/ATP6V1C2/SUMF1/LAMP1/ACP2/ROGDI/AP2B1/AP4E1/SCARB2	4.2528728404071
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	44/996	232/9376	1.78534828971057	ITGB1/ITGB4/IQGAP2/MYH10/ITGA6/ITGAV/EGFR/ITGB8/GNA12/SCIN/DIAPH2/ROCK1/GNG12/IQGAP1/HRAS/KRAS/SLC9A1/WASF2/ITGB5/ROCK2/FGFR2/PFN2/PPP1R12B/PPP1R12A/PIP5K1A/MRAS/PAK6/SSH2/ARPC5/PDGFD/PIP5K1B/LIMK2/BAIAP2/DOCK1/PIK3R3/RDX/CYFIP1/TIAM1/ARPC1B/PTK2/NCKAP1/DIAPH1/ACTN4/WASL	4.17572110075438
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	31/996	144/9376	2.02655064703257	LIFR/ZFHX3/IL6ST/TBX3/DUSP9/ISL1/HRAS/KRAS/IGF1R/GSK3B/BMP4/SMAD5/DVL3/ID2/RIF1/FGFR2/REST/JARID2/ID1/BMPR1A/FZD5/PIK3R3/FZD6/FZD10/SMAD4/SMARCAD1/KAT6A/SMAD2/ID4/ACVR2B/WNT4	4.27963792341496
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	37/996	184/9376	1.89296315697573	ITGB1/SEMA6D/MET/SEMA6A/EPHB4/BMP7/NRP1/PLXNB1/ROCK1/CAMK2G/RASA1/HRAS/SEMA7A/KRAS/SEMA3F/GSK3B/PLXNB2/SEMA4B/SRGAP1/EFNA1/NFATC3/ROCK2/EFNA5/NTN4/PLXNA1/PARD3/PAK6/SSH2/DPYSL2/LIMK2/PIK3R3/EPHA2/NCK1/PPP3CA/PTK2/LRRC4/WNT4	4.21726355052142
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	16/996	54/9376	2.78923099806634	DNMT3A/MTR/CDO1/LDHB/GCLM/AHCYL2/AHCYL1/MAT2A/MAT2B/DNMT1/AMD1/CISD1/APIP/MTAP/GOT2/TST	4.5457133127499
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	33/996	158/9376	1.96614305322556	TFDP2/PRKDC/GADD45B/CDK6/ATRX/MDM2/STAG1/NIPBL/GSK3B/MCM6/WAPL/PDS5A/SKP2/MCM2/GADD45A/CDKN1A/ANAPC5/SMC3/ATR/MCM3/E2F4/MCM5/CCND1/EP300/ANAPC1/SMAD4/MCM7/RAD21/ATM/SMAD2/DBF4/ORC6/CDC14B	4.22225953605749
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	43/996	227/9376	1.78320329777259	SLC26A2/MT-ND3/MT-ND6/MT-CO2/MET/EGFR/MT-ND4L/MT-ND4/FOS/MT-CO3/JUN/MT-CYB/MT-ND2/MT-ND1/NFE2L2/MT-ND5/COX6A1/CAT/CBR1/HRAS/MT-CO1/KRAS/NDUFB9/SOD1/NDUFB1/NDUFS8/MT-ATP8/MGST3/NDUFB7/NDUFS1/NDUFS6/MT-ATP6/NDUFS7/MAPK8/PIK3R3/SLC25A4/GSTM3/NDUFA5/PTPN1/MGST2/PTK2/EPHX2/NDUFB10	4.11807185615798
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	46/996	250/9376	1.7321124497992	TFRC/EGFR/KIF5B/HSPA8/CLTC/RAB11FIP1/MDM2/EPN2/HRAS/IGF1R/VPS36/NEDD4/CYTH3/AP2A2/SH3KBP1/WWP1/SMURF2/RABEP1/DNAJC6/LDLR/ZFYVE16/FGFR2/MVB12B/EEA1/PIP5K1A/PARD3/PRKCI/ZFYVE9/FOLR1/ARPC5/AP2A1/RAB31/PIP5K1B/PSD3/TGFBR2/LDLRAP1/SNX4/CBL/ARPC1B/SH3GLB2/RAB11FIP2/SMAD2/PSD4/AP2B1/IST1/WASL	4.04483548622048
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	30/996	142/9376	1.98880027150857	DDB1/BIRC6/MDM2/SOCS1/NEDD4/WWP1/HUWE1/SMURF2/UBE2F/FBXW11/SKP2/HERC4/UBE2G2/CUL5/UBE4B/UBR5/ANAPC5/MAP3K1/HERC2/UBE3A/TRIP12/UBE2Q1/UBE4A/KLHL9/UBE2H/RNF7/TRIM37/ANAPC1/CBL/UBE2S	4.09308828506134
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	39/996	204/9376	1.79966926529648	ITGB1/ITGAV/MET/EGFR/CTSL/GPC3/ROCK1/GAB1/DDX5/CAMK2G/MDM2/IQGAP1/ANK3/ITPR2/HRAS/KRAS/GPC1/IGF1R/SLC9A1/CASP3/ITGB5/ROCK2/CDKN1A/PPP1R12B/PPP1R12A/MRAS/CCND1/FZD5/PIK3R3/FRS2/RDX/FZD6/FZD10/TIAM1/CBL/SMAD2/ERBB3/PTK2/WNT4	3.98095037003439
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	34/996	170/9376	1.88273092369478	MET/EGFR/LRP5/NFE2L2/GADD45B/CDK6/GAB1/TCF7L2/BRD7/HRAS/KRAS/IGF1R/GSK3B/DVL3/TXNRD1/SMARCA2/SMARCD1/PBRM1/GADD45A/MGST3/CDKN1A/ARID1A/CCND1/FZD5/TGFBR2/PIK3R3/GSTM3/FZD6/FZD10/SMAD4/MGST2/SMAD2/WNT4/SMARCE1	4.00415254674495
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	38/996	203/9376	1.76216194828575	ITGB1/ITGB4/ITGA6/LAMC1/ITGAV/MET/LAMB1/EGFR/LAMA5/PGF/ITGB8/JUN/COL4A2/ROCK1/ARHGAP5/HRAS/BCL2/IGF1R/GSK3B/ITGB5/ROCK2/PPP1R12B/PPP1R12A/PIP5K1A/PAK6/PDGFD/PIP5K1B/RAPGEF1/DOCK1/CCND1/MAPK8/COL4A1/PIK3R3/TLN1/PTK2/DIAPH1/ACTN4/LAMB4	3.78471239646852
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	38/996	205/9376	1.74497012440004	MT-ND3/MT-ND6/MT-CO2/MT-ND4L/MT-ND4/MT-CO3/MT-CYB/MT-ND2/MT-ND1/PARP1/MT-ND5/COX6A1/CAMK2G/SLC2A1/MT-CO1/NDUFB9/GSK3B/CPT2/MPC2/NDUFB1/ATP2A2/NDUFS8/MT-ATP8/NDUFB7/PDK2/NDUFS1/GFPT1/NDUFS6/GSR/MT-ATP6/NDUFS7/MAPK8/TGFBR2/PIK3R3/SLC25A4/NDUFA5/SMAD2/NDUFB10	3.71792597379873
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	20/996	87/9376	2.16405853298251	EGFR/PMAIP1/FOS/JUN/GADD45B/TCF7L2/HRAS/KRAS/BCL2/GSK3B/CASP3/GADD45A/CDKN1A/APPL1/CCND1/MAPK8/TGFBR2/PIK3R3/SMAD4/SMAD2	3.76047981344627
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	18/996	75/9376	2.25927710843373	PMAIP1/GADD45B/CDK6/MDM2/BCL2/CASP3/STEAP3/PPP1R13L/GADD45A/CDKN1A/SHISA5/ATR/SIVA1/CCND1/ATM/MDM4/EI24/PIDD1	3.77468240100011
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	51/996	308/9376	1.55875449851353	MT-ND3/MT-ND6/MT-CO2/MT-ND4L/MT-ND4/KIF5B/MT-CO3/PSMD1/MT-CYB/MT-ND2/MT-ND1/GNAQ/MT-ND5/CLTC/COX6A1/TFAM/GPX8/POLR2J3/RCOR1/MT-CO1/NDUFB9/SOD1/POLR2A/CASP3/AP2A2/NDUFB1/NDUFS8/MT-ATP8/REST/NDUFB7/POLR2L/NDUFS1/NDUFS6/MT-ATP6/AP2A1/PPARG/NDUFS7/POLR2F/MAPK8/ULK2/SLC25A4/EP300/POLR2I/NDUFA5/AP2B1/CREB3L2/POLR2B/DNAH14/HTT/WIPI2/NDUFB10	3.43743055666365
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	8/996	21/9376	3.58615414037101	CHPF/B3GAT3/XYLT1/CHST12/CHSY1/CHST14/CHST11/CHPF2	4.09011440385575
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	41/996	235/9376	1.642382295138	MT-ND3/MT-ND6/MT-CO2/MT-ND4L/MT-ND4/MT-CO3/MT-CYB/MT-ND2/MT-ND1/MT-ND5/COX6A1/ACSL3/HRAS/MT-CO1/KRAS/NDUFB9/CPT2/ADCY7/NDUFB1/SMARCA2/SMARCD1/NDUFS8/MT-ATP8/NDUFB7/NDUFS1/CPT1A/NDUFS6/MT-ATP6/ARID1A/PPARG/NDUFS7/MGLL/FRS2/ACSL4/NDUFA5/COX17/NDUFAF4/CREB3L2/COX19/SMARCE1/NDUFB10	3.43814301185707
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	11/996	37/9376	2.79865407576251	CDH1/GADD45B/TCF7L2/HRAS/KRAS/TPR/GADD45A/CDKN1A/PPARG/CCDC6/CCND1	3.77912814577373
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	27/996	138/9376	1.84180199057098	MT-ND3/MT-ND6/MT-CO2/MT-ND4L/MT-ND4/MT-CO3/MT-CYB/MT-ND2/MT-ND1/MT-ND5/COX6A1/ATP6V1B1/MT-CO1/NDUFB9/NDUFB1/NDUFS8/MT-ATP8/NDUFB7/ATP6V1H/NDUFS1/NDUFS6/MT-ATP6/NDUFS7/ATP6V1C2/NDUFA5/COX17/NDUFB10	3.43442321195309
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	20/996	93/9376	2.02444185343525	ITGB1/ITGA6/LAMC1/ITGAV/LAMB1/LAMA5/COL4A2/GADD45B/CDK6/BCL2/CASP3/TRAF4/SKP2/GADD45A/CDKN1A/CCND1/COL4A1/PIK3R3/PTK2/LAMB4	3.42277152527309
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	60/996	388/9376	1.45571978636194	MT-ND3/MT-ND6/MT-CO2/LRP1/SLC39A10/APP/MT-ND4L/MT-ND4/KIF5B/MT-CO3/LRP5/PSMD1/MT-CYB/MT-ND2/MT-ND1/GNAQ/MT-ND5/COX6A1/ITPR2/HRAS/MT-CO1/RTN4/KRAS/NDUFB9/GSK3B/CASP3/DVL3/NDUFB1/ATP2A2/NDUFS8/MT-ATP8/NDUFB7/SLC11A2/NDUFS1/IDE/NCSTN/NDUFS6/MT-ATP6/NAE1/IRS2/SLC39A1/NDUFS7/MME/ADAM10/MAPK8/FZD5/DDIT3/ATF6/ULK2/PIK3R3/SLC25A4/PSEN2/FZD6/FZD10/NDUFA5/PPP3CA/CALM2/WNT4/WIPI2/NDUFB10	3.16064350815508
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	15/996	62/9376	2.27749708511465	TLE4/RBPJ/TLE1/MAML3/HES1/DVL3/JAG1/NCSTN/SNW1/EP300/PSEN2/TLE3/SPEN/NOTCH3/DTX4	3.47921241139355
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	24/996	122/9376	1.85186648232273	ITGAV/NCOA3/SLC2A1/MDM2/MED16/HRAS/SLC16A2/KRAS/NCOA2/GSK3B/SLC9A1/RCAN1/BMP4/ATP2A2/MED12L/ATP1A1/CCND1/NCOA1/PIK3R3/EP300/NCOR1/MED13/NOTCH3/WNT4	3.26497602537663
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	26/996	137/9376	1.78653299328702	CTSC/PMAIP1/FOS/JUN/CTSL/PARP1/GADD45B/ITPR2/HRAS/CTSV/KRAS/BCL2/CASP3/SPTAN1/CTSO/CFLAR/CTSF/GADD45A/DFFA/ENDOG/MAPK8/DDIT3/CASP2/PIK3R3/ATM/PIDD1	3.19711341756111
NA	NA	hsa04518	Integrin signaling	28/996	154/9376	1.71157356699525	FBN1/ITGB1/ITGB4/ITGA6/LAMC1/ITGAV/MET/LAMB1/EGFR/LAMA5/CDH1/PGF/ITGB8/COL4A2/FERMT1/FRAS1/IGF1R/GSK3B/ITGB5/FERMT2/PDGFD/CCND1/COL4A1/PIK3R3/TLN1/PTK2/ACTN4/LAMB4	3.06945242513258
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	30/996	170/9376	1.66123316796598	ITGB1/MYH10/JUN/JAM3/ROCK1/DLG1/CLDN4/TJP1/NEDD4/MARVELD3/AMOT/ROCK2/PARD3/PRKCI/F11R/MAP3K1/ARHGAP17/MAGI1/ARPC5/OCLN/SYMPK/CCND1/MAPK8/RDX/RAPGEF2/TIAM1/DLG2/MARVELD2/ARPC1B/ACTN4	2.99941737899136
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	43/996	268/9376	1.51039980818798	MT-ND3/MT-ND6/MT-CO2/SLC39A10/MT-ND4L/DUSP1/MT-ND4/KIF5B/MT-CO3/PSMD1/MT-CYB/MT-ND2/MAOA/MT-ND1/NFE2L2/MT-ND5/COX6A1/CAMK2G/ITPR2/MT-CO1/NDUFB9/SOD1/CASP3/NDUFB1/NDUFS8/MT-ATP8/NDUFB7/UBE2G2/SLC11A2/NDUFS1/NDUFS6/MT-ATP6/SLC39A1/NDUFS7/MAPK8/DDIT3/ATF6/SLC25A4/NDUFA5/GPR37/PINK1/CALM2/NDUFB10	2.92253476923077
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	31/996	178/9376	1.63945670321736	LGR5/LGR4/TLE4/RNF43/LRP5/ZNRF3/JUN/TBL1X/SERPINF1/TLE1/CAMK2G/TCF7L2/GSK3B/DVL3/FBXW11/NFATC3/ROCK2/CCND1/MAPK8/FZD5/RUVBL1/EP300/FZD6/FZD10/APCDD1/TLE3/TBL1XR1/SMAD4/NOTUM/PPP3CA/WNT4	2.96939341386003
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	28/996	157/9376	1.67886833960044	DLG5/RASSF6/CDH1/BMP7/FRMD6/LATS2/DLG1/TEAD1/TCF7L2/GSK3B/BMP4/DVL3/ID2/FBXW11/AMOT/PARD3/PRKCI/ID1/BMPR1A/CCND1/FZD5/TGFBR2/FZD6/FZD10/DLG2/SMAD4/SMAD2/WNT4	2.9572413609771
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	13/996	55/9376	2.22504563709383	PLPP3/PSAP/HEXA/ASAH1/GLB1/B4GALT5/SPTLC3/SGMS2/DEGS1/SGPP1/SGMS1/CERS6/KDSR	3.14120049195542
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	13/996	56/9376	2.18531267928858	RPN2/GANAB/MAN1A2/FUT8/TUSC3/B4GALT1/MAN2A1/DPM3/MAN2A2/DDOST/MAN1C1/ALG10B/MOGS	3.06698947416222
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	21/996	110/9376	1.79715224534502	FBN1/TFRC/BMP7/LTBP1/ROCK1/BMP4/SMAD5/SMURF2/ID2/ZFYVE16/ZFYVE9/ID1/E2F4/BMPR1A/TGFBR2/EP300/SMAD4/NCOR1/SMAD2/ID4/ACVR2B	2.899243995978
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	14/996	63/9376	2.09192324854975	KMT2C/HADHA/ASH1L/SMYD2/SETD2/SETD7/DHTKD1/KMT2A/NSD1/PRDM2/ALDH7A1/KMT5A/EZH2/PLOD1	2.99785680206071
NA	NA	hsa04517	IgSF CAM signaling	46/996	299/9376	1.44825455668829	ITGB1/NRP2/MYH10/APP/CDH1/NRP1/DYNLL2/PTPRF/SORBS1/JAM3/NRCAM/MTSS1/IQGAP1/RASA1/ANK3/TJP1/ERC1/SPTBN1/GSK3B/SRGAP1/SPTAN1/NLGN4X/LMO7/PPFIA1/GRIP1/PLXNA1/PARD3/PRKCI/F11R/MAGI1/PAK6/ARPC5/EPB41L3/BAIAP2/MAPK8/CNTNAP2/PIK3R3/RDX/RAPGEF2/TRIO/NCK1/ARPC1B/PTK2/ACTN4/CADM1/WASL	2.7157040350487
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	6/996	17/9376	3.32246633593196	NRP2/DAG1/MYH10/TFRC/PCDH11X/LAMP1	3.3040945208964
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	24/996	133/9376	1.69870459280732	EGFR/HOMER1/GADD45B/CAT/MDM2/HRAS/KRAS/IGF1R/PLK2/SETD7/SKP2/GADD45A/CDKN1A/G6PC3/FOXO4/IRS2/CCND1/MAPK8/TGFBR2/PIK3R3/EP300/SMAD4/ATM/USP7	2.79773283628075
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	50/996	333/9376	1.41346165442551	ITGB1/ITGB4/ITGA6/LAMC1/ITGAV/LAMB1/EGFR/LAMA5/ITGB8/RBPJ/COL4A2/CDK6/DLG1/MDM2/ATP6V1B1/MAML3/TCF7L2/HRAS/KRAS/GSK3B/CASP3/ITGB5/HES1/DVL3/CHD4/CDKN1A/UBR4/IRF3/PARD3/PRKCI/ATP6V1H/MAGI1/JAG1/UBE3A/ATR/ATP6V1C2/CCND1/FZD5/COL4A1/PIK3R3/EP300/FZD6/FZD10/DLG2/ATM/PTK2/CREB3L2/NOTCH3/WNT4/LAMB4	2.64846591167841
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	26/996	149/9376	1.64265114147867	MT-ND3/MT-ND6/MT-ND4L/MT-ND4/GABRE/MT-ND2/MT-ND1/GNAQ/MT-ND5/GNG12/ITPR2/NDUFB9/ADCY7/NDUFB1/NDUFS8/NDUFB7/NDUFS1/NDUFS6/GNG5/NDUFS7/MGLL/MAPK8/NDUFA5/NAPEPLD/GABRA4/NDUFB10	2.72603517424352
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	20/996	106/9376	1.77616124876866	SPINT1/EGFR/HSP90B1/MDM2/TCF7L2/HRAS/KRAS/BCL2/IGF1R/GSK3B/SLC19A1/FGFR2/CDKN1A/FOLR1/PDGFD/ETV5/CCND1/PIK3R3/EP300/CREB3L2	2.77050105374342
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	27/996	157/9376	1.61890875604328	LRP1/ITGAV/DNMT3A/PBX1/ANO6/CAMK2G/SLC2A1/CD47/ABCA1/CD24/P2RY6/CASP3/ITGB5/ATP2A2/SLC16A1/NFATC3/LIPA/TMEM30A/XKR8/CPT1A/TGFBRAP1/PPARG/ADAM10/DOCK1/BSG/DUSP16/PTK2	2.69604938878032
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	6/996	18/9376	3.13788487282463	HEXA/GLB1/MANBA/FUCA2/FUCA1/MAN2B2	3.12984149843041
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	6/996	19/9376	2.97273303741281	GNS/HEXA/HGSNAT/GLB1/GUSB/NAGLU	2.96735906742916
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	25/996	148/9376	1.5901443612287	EGFR/FOS/LRP5/JUN/NCOA3/GADD45B/CDK6/TCF7L2/HRAS/KRAS/IGF1R/GSK3B/HES1/DVL3/GADD45A/CDKN1A/JAG1/CCND1/FZD5/NCOA1/PIK3R3/FZD6/FZD10/NOTCH3/WNT4	2.49475915316343
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	10/996	43/9376	2.18922200429625	HADHA/ACSL3/ADH5/CPT2/ACADS/CPT1A/ECI1/ACSL4/ALDH7A1/ACADL	2.6945101840469
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	16/996	83/9376	1.81468040838051	CBX4/YAF2/MTF2/SUZ12/DCAF7/JARID2/KDM2A/LCOR/RBBP4/EP300/AEBP2/TEX10/EZH2/L3MBTL3/USP7/SFMBT1	2.57005044723723
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	13/996	63/9376	1.94250015936763	DDB1/POLR2J3/POLR2A/POLR2L/XPC/XPA/POLR2F/POLR2I/POLE4/POLR2B/ERCC4/RPA2/RFC1	2.58761823915392
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	13/996	63/9376	1.94250015936763	GADD45B/GLI3/TCF7L2/GSK3B/BMP4/DVL3/PTCH2/GADD45A/CDKN1A/FZD5/FZD6/FZD10/WNT4	2.58761823915392
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	26/996	157/9376	1.55894917248612	GADD45B/CDK6/MDM2/RAD50/ITPR2/HRAS/KRAS/HIPK2/FBXW11/NFATC3/TRPM7/GADD45A/CDKN1A/MRAS/ATR/E2F4/RBBP4/CCND1/TGFBR2/PIK3R3/SLC25A4/ATM/PPP3CA/SMAD2/CALM2/LIN9	2.43485741658355
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	6/996	20/9376	2.82409638554217	DHCR24/FDFT1/LBR/LIPA/SQLE/SOAT1	2.81521113858609
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	25/996	150/9376	1.56894243641232	MET/EGFR/CDH1/LRP5/ABCB1/GADD45B/GAB1/TCF7L2/HRAS/KRAS/BCL2/GSK3B/DVL3/FGFR2/GADD45A/CDKN1A/CCND1/FZD5/TGFBR2/PIK3R3/FZD6/FZD10/SMAD4/SMAD2/WNT4	2.42158953272688
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	10/996	44/9376	2.13946695874407	RPN2/MAN1A2/HEXA/FUT8/TUSC3/B4GALT1/MAN2A1/MAN2A2/DDOST/MAN1C1	2.6117644590386
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	18/996	99/9376	1.71157356699525	EGFR/FOS/JUN/NCOA3/MDM2/HRAS/KRAS/BCL2/IGF1R/ADCY7/CDKN1A/JAG1/CCND1/MAPK8/PIK3R3/NCOR1/PTK2/NOTCH3	2.45373085432262
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	18/996	99/9376	1.71157356699525	EGFR/PLPP3/FOS/JUN/CHPT1/GPCPD1/HRAS/KRAS/WASF2/PIP5K1A/SLC44A2/SLC44A1/PDGFD/PIP5K1B/DGKA/MAPK8/SLC22A5/PIK3R3	2.45373085432262
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	15/996	78/9376	1.81031819586036	ITGB1/MET/CDH1/CLTC/GAB1/WASF2/ARHGAP10/ARPC5/DOCK1/PIK3R3/ELMO3/CBL/ARPC1B/PTK2/WASL	2.47743015632448
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	44/996	300/9376	1.38066934404284	MAP3K4/MET/EGFR/DUSP1/FOS/PGF/HSPA8/JUN/DUSP6/GNA12/GADD45B/NF1/GNG12/RASA1/DUSP9/HRAS/KRAS/IGF1R/TAOK1/JUND/CASP3/RPS6KA5/EFNA1/NFATC3/FGFR2/EFNA5/GADD45A/NR4A1/MRAS/MAP3K1/PDGFD/TAOK3/MAPK8/TGFBR2/DDIT3/EPHA2/MAP3K2/RAPGEF2/PPM1B/DUSP16/PPP3CA/ERBB3/MAP4K4/ANGPT1	2.31022662961587
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	8/996	32/9376	2.35341365461847	ACSS1/HADHA/LDHB/ACADS/ECHDC1/BCKDHB/MCEE/SUCLG1	2.64382330272481
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	9/996	39/9376	2.17238183503244	GLDC/MTR/AHCYL2/AHCYL1/MAT2A/MAT2B/GART/ALDH7A1/MTHFD2L	2.5292455993517
Human Diseases	Cancer: specific types	hsa05218	Melanoma	14/996	73/9376	1.80535841998129	MET/EGFR/CDH1/GADD45B/CDK6/MDM2/HRAS/KRAS/IGF1R/GADD45A/CDKN1A/PDGFD/CCND1/PIK3R3	2.38140039456666
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	7/996	28/9376	2.35341365461847	B3GNT2/B4GALT1/B3GNT5/ST3GAL6/GCNT2/B3GNT3/A4GALT	2.47254107871509
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	32/996	212/9376	1.42092899901493	ITGB1/MET/EGFR/CDH1/PGF/CTNND1/GNAQ/HRAS/KRAS/IGF1R/ADCY7/EFNA1/FGFR2/PFN2/EFNA5/PARD3/PRKCI/MRAS/MAGI1/KRIT1/EVL/PDGFD/ID1/MAGI3/RAPGEF1/PIK3R3/EPHA2/RAPGEF2/TIAM1/TLN1/CALM2/ANGPT1	2.13711323994344
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	15/996	83/9376	1.70126288285673	SLC27A2/IDH1/CAT/ACSL3/SOD1/PMVK/SLC25A17/GSTK1/FAR1/ACSL4/DHRS4/SCP2/CRAT/ABCD3/EPHX2	2.2122552195646
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/996	70/9376	1.74825014343087	MET/JUN/GAB1/SLC2A1/HRAS/KRAS/EPAS1/CDKN1A/PAK6/RAPGEF1/PIK3R3/EP300/EGLN2	2.1662451469281
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	64/996	480/9376	1.25515394912985	MT-ND3/MT-ND6/MT-CO2/APP/MT-ND4L/MT-ND4/KIF5B/MT-CO3/LRP5/FUS/PSMD1/MT-CYB/MT-ND2/MT-ND1/GNAQ/MT-ND5/COX6A1/CAT/CAMK2G/GPX8/ITPR2/HRAS/MT-CO1/KRAS/BCL2/NDUFB9/SOD1/GSK3B/CASP3/DVL3/NDUFB1/ATP2A2/NDUFS8/C9orf72/MT-ATP8/NDUFB7/UBE2G2/ATXN2/NDUFS1/NDUFS6/MT-ATP6/NDUFS7/MAPK8/FZD5/DDIT3/ATF6/ULK2/SLC25A4/PSEN2/FZD6/FZD10/NDUFA5/TARDBP/PPP3CA/GPR37/OPTN/PINK1/CALM2/WNT4/DNAH14/HTT/WIPI2/TOMM40/NDUFB10	1.97842150540707
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	8/996	36/9376	2.09192324854975	MCM6/MCM2/MCM3/MCM5/MCM7/POLE4/RPA2/RFC1	2.26288885340372
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	18/996	108/9376	1.56894243641232	TNPO1/UPF3A/RANBP2/PNN/UPF2/KPNB1/RANBP17/XPO1/TPR/KPNA6/UPF1/POM121/THOC2/IPO7/IPO8/SNUPN/POM121C/NCBP2	2.05012570760073
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	11/996	57/9376	1.81667018953005	HACD3/HADHA/ACSL3/CPT2/FASN/ACADS/CPT1A/ACSL4/HACD2/SCP2/ACADL	2.13202735753875
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	15/996	86/9376	1.64191650322219	EGFR/JUN/GAB1/CAMK2G/HRAS/KRAS/GSK3B/CDKN1A/PAK6/MAPK8/PIK3R3/CBL/NCK1/ERBB3/PTK2	2.0616417855583
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	15/996	86/9376	1.64191650322219	ITGB1/ITGB4/DAG1/ITGA6/ITGAV/GJA1/DSC2/ITGB8/DSG2/TCF7L2/SSPN/ITGB5/ATP2A2/DMD/SNTB2	2.0616417855583
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	17/996	101/9376	1.58447651994115	GNAQ/CAMK2G/TCF7L2/HRAS/KRAS/GSK3B/ADCY7/DVL3/FZD5/EDN1/EP300/FZD6/FZD10/CALM2/CREB3L2/WNT4/EDNRB	2.03593587394062
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	19/996	117/9376	1.52871314317097	BPTF/BRD7/BAZ2B/BAZ1B/SMARCA2/SMARCD1/PBRM1/CHD4/RSF1/BAZ2A/ARID1A/RBBP4/INO80D/RUVBL1/EPC1/YEATS4/ING3/ACTR6/SMARCE1	1.9839206299767
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	50/996	368/9376	1.27902916011874	MT-ND3/MT-ND6/MT-CO2/MT-ND4L/MT-ND4/KIF5B/MT-CO3/FUS/PSMD1/MT-CYB/MT-ND2/MT-ND1/MT-ND5/COX6A1/CAT/GPX8/MT-CO1/BCL2/NDUFB9/SOD1/RANBP2/CASP3/NDUFB1/SRSF7/NDUFS8/C9orf72/MT-ATP8/TPR/PFN2/NDUFB7/POM121/ATXN2/NDUFS1/NDUFS6/MT-ATP6/NDUFS7/DDIT3/ATF6/ULK2/NDUFA5/POM121C/TARDBP/PPP3CA/OPTN/PINK1/DNAH14/SETX/WIPI2/TOMM40/NDUFB10	1.88257640207628
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/996	31/9376	2.12566394610701	ACSS1/GLDC/GLUL/CAT/PGP/MCEE/ACO1	2.16417934823134
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	11/996	59/9376	1.755088149207	EGFR/CDH1/GADD45B/TCF7L2/HRAS/KRAS/GSK3B/GADD45A/CDKN1A/CCND1/PIK3R3	2.0057597427894
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	10/996	52/9376	1.81031819586036	LRP1/LRP2/LRPAP1/ABCA1/NCEH1/LDLR/LIPA/MYLIP/LDLRAP1/SOAT1	2.01999097307234
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	15/996	89/9376	1.58657100311358	ITGB1/ITGB4/DAG1/ITGA6/LAMC1/ITGAV/LAMB1/LAMA5/ITGB8/COL4A2/CD47/FRAS1/ITGB5/COL4A1/LAMB4	1.91677514256933
Human Diseases	Cancer: specific types	hsa05214	Glioma	13/996	76/9376	1.61023039526527	EGFR/GADD45B/CDK6/CAMK2G/MDM2/HRAS/KRAS/IGF1R/GADD45A/CDKN1A/CCND1/PIK3R3/CALM2	1.84141830398669
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	21/996	138/9376	1.43251265933298	ITGB1/FOS/JUN/GNAQ/ROCK1/PKN2/GSK3B/WASF2/NFATC3/ROCK2/IRF3/PIP5K1A/ARPC5/PIP5K1B/BAIAP2/DOCK1/MAPK8/PIK3R3/ARPC1B/PTK2/WASL	1.764585417135
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	13/996	77/9376	1.58931831220988	EGFR/GADD45B/CDK6/KRAS/RALBP1/GADD45A/CDKN1A/CCND1/MAPK8/TGFBR2/PIK3R3/SMAD4/SMAD2	1.79007189178072
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	13/996	77/9376	1.58931831220988	GADD45B/CDK6/MDM2/HRAS/KRAS/GADD45A/CDKN1A/CCND1/TGFBR2/PIK3R3/SMAD4/CBL/BCR	1.79007189178072
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/996	34/9376	1.93810536262698	POLR2J3/POLR2A/POLR2L/POLR2F/POLR2I/POLR2B/POLR3E	1.88914130501902
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/996	41/9376	1.8368106572632	EGFR/CDH1/MDM2/HRAS/KRAS/RPS6KA5/CDKN1A/CCND1	1.8512082107624
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	13/996	78/9376	1.56894243641232	HSPD1/BTG3/BTG2/DHX36/CNOT6L/XRN2/DDX6/CNOT1/LSM8/LSM1/PABPC4/DIS3L/PARN	1.7394588402202
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	10/996	56/9376	1.68100975329891	LRP2/GLI3/BCL2/GSK3B/SMURF2/FBXW11/PTCH2/CCND1/KIF3A/GAS1	1.76210866690734
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	19/996	125/9376	1.43087550200803	ORMDL1/GNA12/GNAQ/ROCK1/ASAH1/HRAS/KRAS/BCL2/ROCK2/S1PR2/SPTLC3/SGMS2/DEGS1/MAPK8/SGPP1/PIK3R3/SGMS1/CERS6/ORMDL3	1.67188255619111
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	23/996	157/9376	1.37907042181465	MT-CO2/FOS/MT-CO3/JUN/MT-CYB/COX6A1/MT-CO1/NDUFB9/GSK3B/CASP3/NDUFB1/NDUFS8/NDUFB7/NDUFS1/NDUFS6/IRS2/PPARG/NDUFS7/MAPK8/DDIT3/PIK3R3/NDUFA5/NDUFB10	1.65128149999321
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/996	71/9376	1.59104021720686	MET/EGFR/JUN/JAM3/ATP6V1B1/TJP1/CASP3/ATP6V1H/F11R/ATP6V1C2/ADAM10/MAPK8	1.72338106538496
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/996	42/9376	1.7930770701855	TFRC/ACSL3/GCLM/STEAP3/SLC40A1/SLC11A2/LPCAT3/ACSL4	1.7758220268091
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	21/996	142/9376	1.392160190056	ITGAV/DUSP1/FOS/JUN/HSP90B1/CTSL/NFE2L2/GPC1/BCL2/BMP4/MGST3/ASS1/BMPR1A/MAPK8/EDN1/PIK3R3/GSTM3/MGST2/PTK2/ACVR2B/CALM2	1.62332710258739
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	32/996	233/9376	1.29286243687195	FBN1/FBN2/ITGB1/ITGB4/FBLN1/DAG1/MYH10/ITGA6/ITGAV/SYNE2/DSC2/ITGB8/COL4A2/DIAPH2/DSG2/BGN/ANK3/SPTBN1/SSPN/SPTAN1/LBR/ITGB5/PLEC/DMD/ATP1A1/FMNL2/COL4A1/NID1/INF2/TLN1/DIAPH1/SNTB2	1.56059629128377
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	37/996	275/9376	1.26656443957649	MT-ND3/MT-ND6/MT-CO2/LAMC1/MT-ND4L/MT-ND4/KIF5B/MT-CO3/HSPA8/PSMD1/MT-CYB/MT-ND2/MT-ND1/MT-ND5/COX6A1/ITPR2/MT-CO1/NDUFB9/SOD1/GSK3B/CASP3/NDUFB1/NDUFS8/MT-ATP8/NDUFB7/NDUFS1/NDUFS6/MT-ATP6/NDUFS7/MAPK8/DDIT3/PIK3R3/SLC25A4/NDUFA5/PPP3CA/CREB3L2/NDUFB10	1.54673994232283
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	13/996	80/9376	1.52971887550201	MET/EGFR/NF1/GAB1/HRAS/KRAS/BCL2/IGF1R/GSK3B/FGFR2/PDGFD/PIK3R3/ERBB3	1.64034682563483
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	16/996	104/9376	1.44825455668829	PLPP3/PISD/CHPT1/CDS1/GPCPD1/LPIN2/GPD1L/PCYT2/PLD3/LPCAT3/AGPAT1/SGMS2/CDIPT/DGKA/AGPAT3/SGMS1	1.58470332553725
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	12/996	73/9376	1.54745007426968	MET/EGFR/KIF5B/GADD45B/CDK6/HRAS/KRAS/EML4/GADD45A/CDKN1A/CCND1/PIK3R3	1.61877965204814
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	16/996	105/9376	1.4344616561484	JUN/TFEB/HRAS/KRAS/HUWE1/SMURF2/MRAS/TBC1D15/ATG9A/MAPK8/MTX3/AMFR/OPTN/PINK1/TOMM40/ARIH1	1.54339152261578
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	5/996	23/9376	2.04644665618998	PCYOX1/PMVK/ZMPSTE24/ICMT/HMGCR	1.73220322773315
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	5/996	23/9376	2.04644665618998	ENPEP/ATP6AP2/CTSA/LNPEP/MME	1.73220322773315
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	10/996	59/9376	1.59553468109727	IDH1/GPX8/PGD/GCLM/MGST3/GSTK1/GGCT/GSR/GSTM3/MGST2	1.58193383121468
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	7/996	37/9376	1.78096168457614	GLUL/RIMKLB/ASS1/GFPT1/GLUD1/NIT2/GOT2	1.6408682040216
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	20/996	138/9376	1.36429777079332	PHKB/PTPRF/SORBS1/HRAS/FLOT2/KRAS/SOCS1/GSK3B/FASN/PRKCI/G6PC3/IRS2/INPPL1/RAPGEF1/MAPK8/PIK3R3/PTPN1/CBL/CALM2/SOCS4	1.48627911799865
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/996	75/9376	1.50618473895582	GLUL/IDH1/MTR/RPIA/MAT2A/MAT2B/ASS1/PC/ALDH18A1/GOT2/PYCR2/ACO1	1.51728846097096
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	12/996	75/9376	1.50618473895582	PMAIP1/MDM2/BCL2/CASP3/MGST3/CDKN1A/XPA/PIK3R3/GSTM3/TOP2B/MGST2/ATM	1.51728846097096
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	17/996	115/9376	1.39158372620918	EGFR/FOS/LRP5/GNA12/GNAQ/PDE4B/ITPR2/BCL2/AKAP13/JUND/MMP15/ADCY7/MMP14/CDKN1A/WNK1/CREB3L2/WNK2	1.45659196818594
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/996	24/9376	1.9611780455154	EXTL2/B3GAT3/GLCE/XYLT1/HS6ST2	1.62536353561654
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	17/996	116/9376	1.37958731477635	ACSS1/GLDC/IDH1/CAT/RPIA/ADH5/PGD/ACADS/PGP/PC/GLUD1/ME2/GOT2/OGDH/MCEE/SUCLG1/ACO1	1.41817063955106
NA	NA	hsa04519	Cadherin signaling	51/996	404/9376	1.18835738995586	MET/GJA1/EGFR/CDH1/DSC3/GABRE/LRP5/KRT80/DSC2/CTNND1/DSG2/PCDH11X/ROCK1/FAT1/LATS2/MYO7A/KRT7/TEAD1/TMC5/TCF7L2/HRAS/LIMA1/KRAS/IGF1R/TJP1/TAOK1/GSK3B/RERE/DVL3/MYO1C/ROCK2/MRAS/NCSTN/ARPC5/EVL/TAOK3/ADAM10/CDH26/MAPK8/FZD5/EP300/PSEN2/CYFIP1/FZD6/FZD10/ARPC1B/PTK2/NCKAP1/GABRA4/ACTN4/WNT4	1.33420330476222
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	15/996	101/9376	1.39806751759513	JUN/COL4A2/HRAS/KRAS/BCL2/CASP3/CCND1/MAPK8/EDN1/TGFBR2/COL4A1/PIK3R3/SMAD4/SMAD2/DIAPH1	1.38660820695419
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	14/996	93/9376	1.41710929740467	MAP3K4/EGFR/JUN/GNAQ/CAMK2G/ITPR2/HRAS/KRAS/ADCY7/MMP14/MAP3K1/MAPK8/MAP3K2/CALM2	1.39360747639897
Organismal Systems	Digestive system	hsa04970	Salivary secretion	14/996	93/9376	1.41710929740467	ATP2B1/ADRB1/KCNN4/GNAQ/ATP2B4/ITPR2/SLC9A1/ADCY7/SLC4A2/TRPV6/ATP1A1/CST3/VAMP2/CALM2	1.39360747639897
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/996	33/9376	1.71157356699525	IDH1/DHTKD1/GOT2/BCKDHB/OGDH/ACO1	1.41164957094883
NA	NA	hsa03272	Virion - Hepatitis viruses	8/996	48/9376	1.56894243641232	EGFR/CLDN4/TGOLN2/LDLR/DPP4/OCLN/LAMP1/IST1	1.36234774214154
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	17/996	120/9376	1.33360107095047	MAGED1/JUN/GAB1/CAMK2G/KIDINS220/HRAS/KRAS/BCL2/GSK3B/RPS6KA5/MAP3K1/RAPGEF1/MAPK8/PIK3R3/FRS2/PSEN2/CALM2	1.26794286545229
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/996	26/9376	1.81031819586036	SLC19A3/SLC52A3/SLC19A1/SLC5A6/SLC19A2	1.42636199224796
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/996	19/9376	1.98182202494187	GLDC/DHTKD1/BCKDHB/OGDH	1.47684376601398
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	27/996	205/9376	1.23984719365266	PMAIP1/DDB1/JUN/RBPJ/IL6ST/SCIN/CDK6/DLG1/MDM2/HRAS/KRAS/CASP3/SKP2/CHD4/CDKN1A/UBR4/IRF3/SNW1/UBE3A/CCND1/GTF2E2/PIK3R3/EP300/CREB3L2/ACTN4/USP7/SND1	1.19700654001677
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	21/996	155/9376	1.27539836766421	EGFR/PBX1/GNAQ/CDK6/CAMK2G/TCF7L2/ITPR2/GSK3B/NCEH1/ADCY7/DVL3/KMT2A/LDLR/CDKN1A/NR4A1/CCND1/FZD5/FZD6/FZD10/CREB3L2/WNT4	1.19187716139656
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	45/996	362/9376	1.17020568461692	ITGB1/CSF3R/ITGB4/ITGA6/LAMC1/ITGAV/MET/LAMB1/EGFR/LAMA5/PGF/ITGB8/HSP90B1/COL4A2/PHLPP1/CDK6/GNG12/MDM2/PKN2/GHR/HRAS/KRAS/BCL2/IGF1R/GSK3B/ITGB5/EFNA1/FGFR2/EFNA5/CDKN1A/NR4A1/PRLR/MAGI1/G6PC3/GNG5/PDGFD/CCND1/COL4A1/PIK3R3/EPHA2/ERBB3/PTK2/CREB3L2/LAMB4/ANGPT1	1.13857820792266
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/996	13/9376	2.17238183503244	PRKDC/RAD50/XRCC5	1.45823172822264
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	28/996	216/9376	1.22028856165402	HSPD1/FOS/HSPA8/JUN/HSP90B1/OLR1/NFE2L2/MIB1/CAMK2G/ABCA1/HRAS/KRAS/BCL2/GSK3B/CASP3/LDLR/NFATC3/ROCK2/IRF3/PPARG/VLDLR/MAPK8/DDIT3/ATF6/PIK3R3/PPP3CA/PTK2/CALM2	1.1291831376503
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	21/996	158/9376	1.25118194296172	LRP5/CLIP1/SLC38A9/PRR5/ATP6V1B1/HRAS/KRAS/IGF1R/LPIN2/GSK3B/DVL3/SKP2/ATP6V1H/ATP6V1C2/RICTOR/FZD5/ULK2/PIK3R3/FZD6/FZD10/WNT4	1.09772082965852
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	11/996	75/9376	1.38066934404284	LRP2/HSP90B1/GNAQ/GPX8/ITPR2/ADCY7/PDIA4/GSR/ATP1A1/DUOX1/CREB3L2	1.14105613763277
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/996	36/9376	1.56894243641232	GALNT11/C1GALT1/GCNT4/B4GALT5/B3GNT3/GALNT1	1.17906959055568
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/996	76/9376	1.36250264214754	SLC27A2/OLR1/DBI/SORBS1/ACSL3/CPT2/CPT1A/PPARG/ACSL4/SCP2/ACADL	1.09388028795884
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/996	14/9376	2.01721170395869	B3GNT2/FUT8/B4GALT1	1.31305931819558
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/996	44/9376	1.49762687112085	PARP1/TDG/HMGB1/MUTYH/APEX1/POLE4/RFC1	1.14060716362372
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/996	53/9376	1.42092899901493	ATP2B1/GNAQ/CLTC/ATP2B4/AP2A2/AP2A1/ATP1A1/AP2B1	1.0594055343517
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	27/996	214/9376	1.18770408737755	FOS/DDB1/JUN/GNAQ/GNG12/ITPR2/AP1S3/HRAS/KRAS/BCL2/CASP3/PDIA3/FBXW11/NFATC3/CUL5/IRF3/PAK6/GNG5/ATR/LIMK2/MAPK8/PIK3R3/RNF7/ATM/PPP3CA/PTK2/CALM2	0.957588167002045
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	14/996	103/9376	1.27952587047218	MSI2/FUS/UPF3A/PNN/UPF2/PABPN1/WDR82/UPF1/CPSF2/SYMPK/PABPC4/SMG1/TARDBP/NCBP2	0.983385474651119
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	28/996	224/9376	1.17670682730924	FOS/JUN/NRP1/SLC2A1/DLG1/HRAS/KRAS/ADCY7/NFATC3/XPO1/CDKN1A/ANAPC5/MAP3K1/ATR/CCND1/MAPK8/TGFBR2/PIK3R3/SLC25A4/EP300/ANAPC1/TLN1/SMAD4/ATM/PPP3CA/SMAD2/CREB3L2/ETS2	0.922810719978276
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/996	62/9376	1.36649825106879	HSPA8/CAT/HRAS/KRAS/IGF1R/SOD1/ADCY7/IRS2/PIK3R3	0.998143384223948
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/996	30/9376	1.56894243641232	IDH1/PC/OGDH/SUCLG1/ACO1	1.07599280021374
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	5/996	30/9376	1.56894243641232	PGAP1/PGAP2/PIGS/PIGP/GPAA1	1.07599280021374
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	17/996	130/9376	1.23101637318505	EGFR/FOS/JUN/COL4A2/GNG12/HRAS/KRAS/ADCY7/GNG5/MAPK8/EDN1/TGFBR2/COL4A1/PIK3R3/SMAD2/CREB3L2/EDNRB	0.914388575142226
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/996	71/9376	1.32586684767238	FOS/HRAS/KRAS/SOCS1/GSK3B/PRLR/CCND1/MAPK8/PIK3R3/SOCS4	0.950176889432746
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/996	71/9376	1.32586684767238	MET/EGFR/IDH1/SLC1A5/SLC2A1/HRAS/KRAS/LDHB/FGFR2/PIK3R3	0.950176889432746
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	18/996	139/9376	1.2190344110254	EGFR/FOS/HSPA8/JUN/HSP90B1/GNAQ/NCOA3/ITPR2/HRAS/KRAS/BCL2/NCOA2/ADCY7/NCOA1/PIK3R3/EBAG9/CALM2/CREB3L2	0.8969073349335
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	16/996	122/9376	1.23457765488182	FOS/GNAQ/GHR/ITPR2/HRAS/KRAS/SOCS1/GSK3B/ADCY7/MAP3K1/IRS2/MAPK8/PIK3R3/EP300/PTK2/CREB3L2	0.899073311570982
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/996	23/9376	1.63715732495198	GLUL/ASS1/GLUD1/GOT2	1.05469874486872
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/996	23/9376	1.63715732495198	B4GALT1/B4GAT1/FKRP/B3GALNT2	1.05469874486872
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	28/996	227/9376	1.16115563575889	ITGAV/EGFR/GNA12/GNAQ/ROCK1/CDK6/GNG12/MDM2/ITPR2/HRAS/KRAS/AKAP13/GSK3B/CASP3/ADCY7/PDIA3/NFATC3/ROCK2/CDKN1A/IRF3/GNG5/IL10RB/CCND1/PIK3R3/PPP3CA/PTK2/CALM2/CREB3L2	0.847354052220357
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/996	47/9376	1.40203366658122	ACSS1/ADH5/LDHB/PC/ME2/ALDH7A1/HAGH	0.952548512702447
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	18/996	140/9376	1.21032702237522	CDH1/GNAQ/APELA/TFAM/GNG12/ITPR2/HRAS/KRAS/SLC9A1/ADCY7/MRAS/JAG1/GNG5/CCND1/SMAD4/SMAD2/CALM2/NOTCH3	0.864391380052546
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	25/996	201/9376	1.1708525644868	SPINT1/MET/FUS/DUSP6/PBX1/GADD45B/DDX5/FUT8/MDM2/IGF1R/ETV6/ID2/KMT2A/ASPSCR1/GADD45A/CDKN1A/JMJD1C/PPARG/ETV5/TGFBR2/DDIT3/ATM/NCOR1/CCNT1/PTK2	0.844130888434789
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/996	32/9376	1.47088353413655	PMAIP1/BIRC6/BCL2/CASP3/MAPK8	0.919846534850102
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/996	17/9376	1.66123316796598	GLUL/GLUD1/CA8	0.940714125113317
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	14/996	110/9376	1.19810149689668	TFRC/EGFR/CAMK2G/SLC2A1/BCL2/IGF1R/LDHB/EPAS1/CDKN1A/EDN1/PIK3R3/EP300/EGLN2/ANGPT1	0.720495462222984
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/996	50/9376	1.31791164658635	MAOA/AMD1/OAT/ALDH18A1/GOT2/ALDH7A1/PYCR2	0.777028651927445
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	19/996	154/9376	1.16142492046107	EGFR/FOS/JUN/GNAQ/ROCK1/CAMK2G/ITPR2/HRAS/KRAS/RCAN1/ADCY7/NFATC3/ROCK2/CDKN1A/PPP1R12B/PPP1R12A/CCND1/PPP3CA/CALM2	0.696324507497276
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/996	10/9376	1.88273092369478	SUOX/TST	0.962818801430848
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/996	18/9376	1.56894243641232	ACSL3/FASN/ACSL4	0.832925884053177
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	20/996	166/9376	1.13417525523782	ATP2B1/ADRB1/GNA12/GNAQ/GTF2I/ROCK1/ATP2B4/ITPR2/ADCY7/ATP2A2/NFATC3/ROCK2/PPP1R12A/IRS2/ATP1A1/SLC25A4/PPP3CA/CALM2/CREB3L2/EDNRB	0.601298273861524
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	28/996	238/9376	1.10748877864399	MET/EGFR/PGF/NF1/GAB1/GNG12/RASA1/HRAS/KRAS/IGF1R/RALBP1/EFNA1/KSR1/FGFR2/EFNA5/MRAS/PAK6/GNG5/FOXO4/PDGFD/MAPK8/EXOC2/PIK3R3/EPHA2/TIAM1/CALM2/ETS2/ANGPT1	0.579054349277935
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/996	61/9376	1.23457765488182	ATP2B1/ATP2B4/TRPM7/SLC40A1/TRPV6/SLC11A2/ATP1A1/HMOX2	0.633655817227863
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	13/996	105/9376	1.16550009562058	ITGB1/ITGB4/DAG1/ADRB1/ITGA6/ITGAV/ITGB8/SSPN/ADCY7/ITGB5/ATP2A2/DMD/SNTB2	0.587926324355883
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/996	44/9376	1.28368017524644	DYNLL2/DYNC1H1/DYNC1LI2/DYNC1LI1/VAMP2/CREB3L2	0.65022139848542
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	20/996	169/9376	1.1140419666833	CTSL/BIRC6/HRAS/EIF2AK4/KRAS/BCL2/IGF1R/UVRAG/C9orf72/CFLAR/MRAS/HMGB1/IRS2/ATG9A/MAPK8/ULK2/PIK3R3/LAMP1/OPTN/WIPI2	0.515753610671316
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/996	89/9376	1.16348540228329	ADRB1/GJA1/EGFR/GNAQ/ITPR2/HRAS/KRAS/TJP1/ADCY7/PDGFD/MAP3K2	0.534231582547018
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	7/996	54/9376	1.22028856165402	HES1/RMI2/ATR/USP1/REV1/ERCC4/RPA2	0.559664262713659
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	12/996	99/9376	1.1410490446635	ITGB1/ITGB4/DAG1/ITGA6/ITGAV/ITGB8/SSPN/ITGB5/ATP2A2/DMD/EDN1/SNTB2	0.486381744511701
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	17/996	144/9376	1.11133422579206	PSMD1/RBPJ/GNAQ/AFG3L2/ITPR2/PUM1/ATP2A2/NOP56/PUM2/ATXN2/VLDLR/MAPK8/ULK2/PIK3R3/SLC25A4/OMA1/WIPI2	0.464146777610099
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	29/996	253/9376	1.07903550962744	ITGB1/EGFR/JUN/ROCK1/MDM2/ITPR2/BCL2/GSK3B/CYTH3/WASF2/RPS6KA5/FBXW11/ROCK2/PFN2/IRF3/ARPC5/FOXO4/FNBP1L/DOCK1/MAPK8/PIK3R3/TLN1/ATM/ARPC1B/PTK2/DIAPH1/ACTN4/WIPI2/WASL	0.439346306028742
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/996	12/9376	1.56894243641232	COQ4/GGCX	0.679863219970991
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	9/996	73/9376	1.16058755570226	RANBP2/FURIN/XPO1/PSIP1/AFF4/ELL/SERINC3/EP300/CCNT1	0.474848538270378
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/996	29/9376	1.2984351197895	RASSF6/FRMD6/LATS2/TEAD1	0.554888986793932
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	13/996	109/9376	1.12272944990973	SLC27A2/PTPRF/SLC2A1/GSK3B/GFPT1/G6PC3/CPT1A/IRS2/MAPK8/PIK3R3/SLC27A3/PTPN1/CREB3L2	0.444309657558542
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	23/996	200/9376	1.0825702811245	ITGB1/MYH10/FOS/JUN/GNA12/ROCK1/CLDN4/TJP1/CYTH3/WASF2/CASP3/MYO1C/ROCK2/MYO5B/ARPC5/OCLN/BAIAP2/MAPK8/CYFIP1/NCK1/ARPC1B/NCKAP1/WASL	0.406916552800693
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/996	65/9376	1.15860364535063	PBX1/GNAQ/ITPR2/NCEH1/ADCY7/LDLR/NR4A1/CREB3L2	0.442348926878175
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/996	21/9376	1.34480780263913	AASDHPPT/PANK3/COASY	0.545328423437989
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/996	30/9376	1.25515394912985	MTR/SLC19A1/FOLR1/GART	0.482551124048796
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	6/996	48/9376	1.17670682730924	HADHA/ACADS/IVD/ALDH7A1/BCKDHB/MCEE	0.423129181088667
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	13/996	112/9376	1.09265633964429	ITGB1/ITGA6/LAMC1/LAMB1/LAMA5/HSPA8/SOCS1/BCL2/CASP3/LDLR/IL10RB/MAPK8/LAMB4	0.340077716468747
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/996	94/9376	1.10159788088524	FOS/JUN/HSP90B1/FOSB/USP25/GSK3B/JUND/CASP3/TRAF4/ANAPC5/MAPK8	0.341288058222084
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/996	67/9376	1.12401846190733	GNAQ/CAMK2G/ITPR2/HRAS/KRAS/EP300/PPP3CA/CALM2	0.351208909959326
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	22/996	196/9376	1.0566347020736	FOS/JUN/IL6ST/CDK6/GNG12/TCF7L2/ITPR2/HRAS/KRAS/GSK3B/RCAN1/CASP3/NFATC3/CDKN1A/IRF3/GNG5/CCND1/MAPK8/PIK3R3/EP300/PPP3CA/CALM2	0.276237486330824
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	12/996	105/9376	1.0758462421113	JUN/MDM2/ITPR2/HRAS/KRAS/KSR1/NFATC3/MRAS/MAPK8/PIK3R3/PPP3CA/CALM2	0.269437924935918
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/996	32/9376	1.17670682730924	GAA/B4GALT1/GLB1/G6PC3	0.345187612225198
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/996	69/9376	1.09143821663465	FOS/JUN/MAOA/FOSB/CAMK2G/PPP3CA/CALM2/CREB3L2	0.262809302560536
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/996	79/9376	1.07244166539576	SLC6A4/CLTC/ATP6V1B1/AP2A2/ATP6V1H/AP2A1/ATP6V1C2/VAMP2/AP2B1	0.222907075591437
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/996	42/9376	1.12067316886594	MAOA/HADHA/CAT/DHTKD1/ALDH7A1	0.27020585939632
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/996	107/9376	1.05573696655782	PHKB/GNAQ/CAMK2G/SLC2A1/ITPR2/LDHB/G6PC3/CPT1A/EP300/PPP3CA/CALM2/CREB3L2	0.199899668876428
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	8/996	70/9376	1.0758462421113	SLC2A1/ACSL3/APPL1/G6PC3/CPT1A/IRS2/MAPK8/ACSL4	0.219581052310915
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	11/996	98/9376	1.0566347020736	PLPP3/SCIN/WASF2/PIP5K1A/ARPC5/INPPL1/PIP5K1B/LIMK2/DOCK1/PIK3R3/ARPC1B	0.194295065997578
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	11/996	98/9376	1.0566347020736	ATP2B1/GNAQ/CAMK2G/ATP2B4/ITPR2/ADCY7/LDLR/NR4A1/ATP1A1/CALM2/CREB3L2	0.194295065997578
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/996	15/9376	1.25515394912985	HEXA/GLB1	0.340941682094855
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	10/996	90/9376	1.04596162427488	CAT/HRAS/KRAS/IGF1R/ADCY7/APPL1/IRS2/PPARG/PIK3R3/CREB3L2	0.151041253540898
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/996	119/9376	1.02838243731227	FOS/JUN/CASP3/RPS6KA5/MMP14/DNM1L/CFLAR/JAG1/MAPK8/EDN1/PIK3R3/CREB3L2/BAG4	0.107419056684373
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/996	44/9376	1.06973347937203	GTF2I/TAF11/GTF2E2/TAF3/TAF2	0.159835633347124
Genetic Information Processing	Transcription	hsa03040	Spliceosome	26/996	243/9376	1.00722230485729	FUS/HSPA8/SF1/DDX5/RBM25/TRA2B/SRSF6/SRSF7/TCERG1/PRPF38B/RBM17/SRSF10/PRPF40A/THOC2/SNW1/LSM8/PRPF8/RBMX/SRSF2/TRA2A/SF3B2/DDX42/NCBP2/SF3B1/DHX15/SF3A3	0.0393247094336078
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/996	16/9376	1.17670682730924	MAOA/GOT2	0.243875792924277
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/996	16/9376	1.17670682730924	HEXA/A4GALT	0.243875792924277
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	16/996	149/9376	1.01086224090995	EGFR/PLPP3/GNA12/GAB1/HRAS/KRAS/CYTH3/ADCY7/PIP5K1A/MRAS/AGPAT1/PDGFD/PIP5K1B/DGKA/AGPAT3/PIK3R3	0.0460760883789851
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/996	160/9376	1.00020080321285	ITGB1/ITGA6/ITGAV/GLG1/CDH1/ITGB8/PTPRF/JAM3/NRCAM/CLDN4/NLGN4X/NRXN3/F11R/OCLN/CNTNAP2/LRRC4/CADM1	0.000883187093049186
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	11/996	103/9376	1.005341755371	COL14A1/KCNN4/COL4A2/COL21A1/SLC1A5/KCNK5/SLC38A2/DPP4/ATP1A1/MME/COL4A1	0.0187925526610687
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	11/996	103/9376	1.005341755371	LAMC1/LAMB1/LAMA5/COL4A2/GNAQ/CASP3/COL4A1/PIK3R3/PTK2/ACTN4/LAMB4	0.0187925526610687
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/996	65/9376	1.0137781896818	PLPP3/LPIN2/AGPAT1/MGLL/DGKA/AGPAT3/ALDH7A1	0.0384276629115048
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/996	17/9376	1.10748877864399	MTR/TXNRD1	0.15292065985229
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	14/996	133/9376	0.990911012470936	KIF5B/FOS/MAOA/GNAQ/GNG12/CAMK2G/ITPR2/GSK3B/CLOCK/GNG5/MAPK8/PPP3CA/CALM2/CREB3L2	-0.0363938624711746
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/996	27/9376	1.04596162427488	HACD3/HACD2/SCP2	0.0824494890206177
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	26/996	248/9376	0.986915403549683	KIF5B/FOS/JUN/AHNAK/HSP90B1/DYNLL2/DYNC1H1/TCF7L2/HRAS/BCL2/CYTH3/CASP3/SNX18/ROCK2/PFN2/ARPC5/GCC2/MAPK8/EXOC2/RHOB/DYNC1LI2/CYFIP1/DYNC1LI1/ARPC1B/NCKAP1/WASL	-0.0719932294846172
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/996	76/9376	0.990911012470936	GNAQ/CAMK2G/ITPR2/SLC9A1/ADCY7/SLC4A2/ATP1A1/CALM2	-0.0274267360829329
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/996	47/9376	1.00145261898658	SOCS1/IRS2/MAPK8/PIK3R3/SOCS4	0.00344172682591762
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	17/996	163/9376	0.981792199472738	FOS/DDB1/JUN/HRAS/KRAS/BCL2/CASP3/NFATC3/CDKN1A/IRF3/MAP3K1/MAPK8/TGFBR2/PIK3R3/EP300/SMAD4/CREB3L2	-0.0808433034684624
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/996	86/9376	0.985149901933315	KCNN4/GNAQ/CAMK2G/SLC2A1/ADCY7/PCLO/ATP1A1/VAMP2/CREB3L2	-0.0476940264664298
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	12/996	115/9376	0.982294394971189	FOS/GNAQ/GNG12/CAMK2G/ITPR2/HRAS/KRAS/BCL2/ADCY7/GNG5/PIK3R3/CREB3L2	-0.0658603520797535
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/996	28/9376	1.00860585197935	HACD3/HADHA/HACD2	0.0157219653161196
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/996	28/9376	1.00860585197935	MOCS2/CBR1/PCBD1	0.0157219653161196
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	12/996	116/9376	0.973826339842127	ITGB1/CTNND1/JAM3/ROCK1/ARHGAP5/CLDN4/ROCK2/F11R/OCLN/PIK3R3/PTK2/ACTN4	-0.097787030600201
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/996	38/9376	0.990911012470936	HEXA/NAGK/UXS1/GFPT1	-0.0193541306816895
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/996	87/9376	0.973826339842127	MT-CO2/MT-CO3/MT-CYB/ASPH/COX6A1/MT-CO1/SLC9A1/ATP2A2/ATP1A1	-0.0845537555706086
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	16/996	155/9376	0.971732089648918	ITGB1/TFRC/ITGAV/COLEC12/CTSL/OLR1/DYNC1H1/ATP6V1B1/ITGB5/EEA1/ATP6V1H/ATP6V1C2/DYNC1LI2/LAMP1/DYNC1LI1/PLA2R1	-0.122338694428794
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/996	98/9376	0.960577001885091	CDS1/ITPR2/SACM1L/PIP5K1A/INPPL1/PIP5K1B/CDIPT/DGKA/PIK3R3/CALM2	-0.135247361425232
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/996	49/9376	0.960577001885091	GALNT11/C1GALT1/B4GALT1/GXYLT1/GALNT1	-0.0953827850229578
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	23/996	226/9376	0.958026797455308	ATP2B1/ADRB1/FOS/JUN/PDE4B/ROCK1/CAMK2G/ATP2B4/GLI3/SLC9A1/ADCY7/ATP2A2/ROCK2/PPP1R12A/ATP1A1/MAPK8/EDN1/PIK3R3/EP300/TIAM1/PDE10A/CALM2/CREB3L2	-0.220195823657873
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/996	60/9376	0.94136546184739	GNA12/GNAQ/ITPR2/HRAS/KRAS/IGF1R	-0.157075225563818
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/996	70/9376	0.94136546184739	DAG1/CD55/SSPN/CASP3/DMD/CCND1/SNTB2	-0.169751766612523
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/996	90/9376	0.94136546184739	ABCB1/SLC2A1/SLC9A1/NCEH1/ADCY7/LDLR/SLC4A2/ATP1A1/HMGCR	-0.192687579759942
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/996	90/9376	0.94136546184739	EGFR/FOS/JUN/HRAS/KRAS/EML4/NFATC3/PIK3R3/PPP3CA	-0.192687579759942
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	9/996	91/9376	0.931020786442473	FOS/JUN/HRAS/KRAS/GSK3B/NFATC3/INPPL1/PIK3R3/PPP3CA	-0.227950882989096
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/996	51/9376	0.922907315536657	ATP6V1B1/TJP1/PDIA4/ATP6V1H/ATP6V1C2	-0.190312421210469
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/996	41/9376	0.9184053286316	RAD50/TOPBP1/ATM/RPA2	-0.18050526039624
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/996	31/9376	0.910998834045861	HADHA/ACADS/ALDH7A1	-0.171111890002869
NA	NA	hsa04981	Folate transport and metabolism	3/996	31/9376	0.910998834045861	MTR/SLC19A1/FOLR1	-0.171111890002869
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	12/996	122/9376	0.925933241161367	FOS/JUN/DLG1/HRAS/KRAS/GSK3B/NFATC3/PAK6/MAPK8/PIK3R3/NCK1/PPP3CA	-0.283878045331843
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	9/996	93/9376	0.910998834045861	FOS/JUN/RBPJ/MAML3/NFATC3/JAG1/MAPK8/PPP3CA/NOTCH3	-0.297362564329462
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	8/996	83/9376	0.907340204190255	CASP3/POLR2L/ADAR/IRF3/G3BP1/POLR2F/ZCCHC3/POLR3E	-0.292311374143808
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/996	32/9376	0.882530120481928	ATG9A/ULK2/WIPI2	-0.229471310399705
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	15/996	154/9376	0.916914410890315	MOCS2/AK3/GCLM/COQ4/GUSB/MAT2A/MAT2B/DHRS3/NME6/NME3/PANK3/GGCX/COASY/PNPO/MTHFD2L	-0.358399011451749
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/996	43/9376	0.875688801718502	PLPP3/ABCA1/AGPAT1/GOT2	-0.281661278172184
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	11/996	115/9376	0.90043652872359	APP/DUSP1/SLC6A4/MAOA/GNAQ/GNG12/ITPR2/HRAS/KRAS/CASP3/GNG5	-0.370350816132893
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	32/996	323/9376	0.932622129384411	MET/EGFR/DNMT3A/ABCB1/SOX4/DICER1/ROCK1/CDK6/MDM2/HRAS/FOXP1/TP63/KRAS/SOCS1/BCL2/CASP3/RPS6KA5/EFNA1/EFNA5/CDKN1A/DNMT1/IRS2/CCND1/ST14/PIK3R3/EP300/RDX/ATM/EZH2/MDM4/ERBB3/NOTCH3	-0.424830394371979
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	20/996	205/9376	0.9184053286316	JUN/PSMD1/RBPJ/GADD45B/CDK6/MDM2/BCL2/NEDD4/CASP3/HES1/PDIA3/SKP2/GADD45A/CDKN1A/IRF3/SNW1/CCND1/MAPK8/PIK3R3/USP7	-0.407214917844472
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/996	22/9376	0.855786783497627	MAOA/ALDH7A1	-0.233459214036158
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/996	33/9376	0.855786783497627	GOSR1/STX16/VAMP2	-0.28609624449707
Human Diseases	Infectious disease: viral	hsa05162	Measles	13/996	136/9376	0.89983463264824	CD46/FOS/HSPA8/JUN/CDK6/BCL2/GSK3B/CASP3/ADAR/IRF3/CCND1/MAPK8/PIK3R3	-0.405643344504667
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/996	65/9376	0.868952734012975	KCNN4/GNAQ/ITPR2/HRAS/KRAS/PIK3R3	-0.365493601055165
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/996	34/9376	0.830616583982991	BHLHE41/FBXW11/CLOCK	-0.341101565272889
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/996	23/9376	0.818578662475991	RPA2/RFC1	-0.300310220860127
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/996	23/9376	0.818578662475991	GLUD1/ATP1A1	-0.300310220860127
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/996	45/9376	0.836769299419902	ABCB1/ABCA1/ABCD3/ABCB8	-0.37838795636368
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/996	56/9376	0.840504876649455	HSPD1/HSPA8/CASP3/CLK4/CLK1	-0.412692678517473
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/996	67/9376	0.843013846430498	ACSS1/ADH5/LDHB/G6PC3/MINPP1/ALDH7A1	-0.444570389165526
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/996	78/9376	0.84481515806817	ISYNA1/SACM1L/PIP5K1A/MINPP1/INPPL1/PIP5K1B/CDIPT	-0.474455108092641
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/996	78/9376	0.84481515806817	ITGB1/FOS/JUN/CASP3/IRF3/MAPK8/CALM2	-0.474455108092641
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/996	12/9376	0.784471218206158	CD46	-0.257548184506658
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/996	89/9376	0.846171201660575	GABRE/GLUL/SLC38A1/GNG12/ADCY7/SLC38A2/GNG5/GABRA4	-0.502676087469717
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/996	68/9376	0.830616583982991	RDH10/ADH5/ALDH1A3/DHRS3/DHRS4L2/DHRS4	-0.483270687806472
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/996	68/9376	0.830616583982991	DUSP6/TCF7L2/HRAS/KRAS/CCND1/PIK3R3	-0.483270687806472
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/996	36/9376	0.784471218206158	AGL/GAA/G6PC3	-0.446659303716386
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	13/996	142/9376	0.861813450987047	FOS/JUN/FOSB/ITPR2/SOCS1/JUND/ATP2A2/TMEM64/PPARG/MAPK8/TGFBR2/PIK3R3/PPP3CA	-0.572016170722776
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/996	69/9376	0.818578662475991	ADRB1/GNAQ/ITPR2/EDN1/PPP3CA/CALM2	-0.521436407435512
Human Diseases	Substance dependence	hsa05032	Morphine addiction	8/996	91/9376	0.82757403239331	GABRE/PDE4B/GNG12/ADCY7/PDE7A/GNG5/PDE10A/GABRA4	-0.569804286524888
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/996	59/9376	0.797767340548635	ENTPD6/NME6/CANT1/NME3/TK2	-0.537195726658912
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/996	59/9376	0.797767340548635	ADRB1/ADCY7/IRS2/MGLL/PIK3R3	-0.537195726658912
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/996	37/9376	0.763269293389775	MAOA/ADH5/GOT2	-0.497391737730524
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/996	37/9376	0.763269293389775	NAGK/UXS1/GFPT1	-0.497391737730524
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	9/996	102/9376	0.830616583982991	ATP2B1/GNAQ/ATP2B4/ITPR2/SLC9A1/ADCY7/ATP2A2/SLC4A2/ATP1A1	-0.592967274242975
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	13/996	144/9376	0.849843819723338	TCF7L2/ADH5/TRA2B/LPIN2/GSK3B/FASN/CASP3/IRF3/CPT1A/CCND1/MAPK8/TRA2A/ALDH7A1	-0.625993549762719
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	12/996	134/9376	0.843013846430498	MYH10/GNA12/GNAQ/ROCK1/ITPR2/ADCY7/ROCK2/PPP1R12B/PPP1R12A/EDN1/CALM2/RAMP1	-0.63099230615465
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/996	60/9376	0.784471218206158	HRAS/KRAS/PIK3R3/PPP3CA/PTK2	-0.577376970679787
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/996	49/9376	0.768461601508073	JUN/MAOA/FOSB/CREB3L2	-0.560200348627559
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/996	82/9376	0.80360466255265	GUSB/MGST3/NME6/NME3/TK2/GSTM3/MGST2	-0.615786357931345
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	20/996	217/9376	0.867617937186534	ADRB1/EGFR/FOS/JUN/HSP90B1/HRAS/KRAS/BCL2/ADCY7/KLF5/KPNB1/KPNA6/MGST3/JAG1/CCND1/PIK3R3/GSTM3/MGST2/CREB3L2/EPHX2	-0.680186925358355
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/996	38/9376	0.743183259353202	KRAS/ATP1A1/PIK3R3	-0.546866715773321
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	14/996	156/9376	0.84481515806817	EGFR/CDK6/CLDN4/HRAS/KRAS/GSK3B/CASP3/LDLR/CFLAR/CDKN1A/IRF3/OCLN/CCND1/PIK3R3	-0.673813076472399
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/996	27/9376	0.697307749516585	HADHA/ACADS	-0.542992589504715
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/996	105/9376	0.806884681583477	PARP1/GADD45B/BCL2/ERC1/PPP1R13L/CFLAR/GADD45A/ATM/PIDD1	-0.686027273323978
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	15/996	168/9376	0.840504876649455	CSF3R/EGFR/LIFR/IL6ST/GHR/HRAS/SOCS1/BCL2/CDKN1A/PRLR/IL10RB/CCND1/PIK3R3/EP300/SOCS4	-0.719138752637448
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	10/996	116/9376	0.811521949868439	GLUL/GNAQ/SLC38A1/HOMER1/GNG12/ITPR2/ADCY7/SLC38A2/GNG5/PPP3CA	-0.704170098660706
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/996	73/9376	0.773725037134841	MAOA/ADH5/MGST3/GSTK1/GSTM3/MGST2	-0.669082575507388
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/996	51/9376	0.738325852429325	PLPP3/CHPT1/PAFAH1B2/PLD3	-0.645973621738904
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	12/996	138/9376	0.818578662475991	CPEB4/CAMK2G/ITPR2/IGF1R/ADCY7/FBXW11/SLK/ANAPC5/SMC3/ANAPC1/PPP3CA/CALM2	-0.740171275092152
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/996	85/9376	0.775242145050791	PNP/AK3/ENTPD6/NME6/CANT1/NME3/TK2	-0.717606575479907
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	11/996	128/9376	0.8089859437751	PNP/PDE4B/AK3/ADCY7/ENTPD6/NME6/CANT1/PDE7A/GART/NME3/PDE10A	-0.750135466422314
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/996	28/9376	0.672403901319564	ATP6V1B1/ATP6V1C2	-0.598482813033624
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/996	52/9376	0.724127278344146	IGF1R/ADCY7/LDLR/HSD17B1	-0.687705657244987
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/996	97/9376	0.776383886059703	FOS/GNAQ/GNG12/CAMK2G/ADCY7/RPS6KA5/GNG5/CALM2	-0.763188247208505
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/996	41/9376	0.6888039964737	GLDC/MAOA/ALDH7A1	-0.6884336281859
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/996	109/9376	0.777274234552891	FOS/JUN/IL6ST/NFATC3/MAPK8/TGFBR2/SMAD4/PPP3CA/SMAD2	-0.806319987973998
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	13/996	154/9376	0.794659156104939	ATP2B1/ADRB1/GNAQ/CAMK2G/ATP2B4/BCL2/SLC9A1/ADCY7/RPS6KA5/ATP2A2/ATP1A1/CALM2/CREB3L2	-0.885760770926262
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	10/996	122/9376	0.771611034301139	IGF1R/FASN/G6PC3/CPT1A/IRS2/PPARG/CCND1/PIK3R3/HMGCR/CREB3L2	-0.875353723783255
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/996	17/9376	0.553744389321994	SCP2	-0.634872805408737
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/996	17/9376	0.553744389321994	CDO1	-0.634872805408737
NA	NA	hsa04081	Hormone signaling	19/996	219/9376	0.81670976142011	ADRB1/ITGAV/GNA12/GNAQ/GNG12/GHR/SLC16A2/IGF1R/ADCY7/SMAD5/SLC40A1/PRLR/APPL1/GNG5/IRS2/BMPR1A/PIK3R3/SMAD4/RAMP1	-0.946189414225594
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/996	31/9376	0.607332556030574	RPIA/PGD	-0.754934699561421
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/996	31/9376	0.607332556030574	GUSB/ALDH7A1	-0.754934699561421
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/996	31/9376	0.607332556030574	SEC62/SEC63	-0.754934699561421
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/996	79/9376	0.71496111026384	CBR1/ADH5/MGST3/GSTK1/GSTM3/MGST2	-0.87708068269557
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/996	18/9376	0.522980812137439	MTR	-0.698351192198311
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/996	103/9376	0.731157640269817	FOS/JUN/GNAQ/CFLAR/MAPK8/TGFBR2/PIK3R3/SMAD2	-0.945800369328981
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	22/996	254/9376	0.815355911836322	ATP2B1/ADRB1/MET/EGFR/PHKB/GNAQ/ASPH/CAMK2G/ATP2B4/TFEB/ITPR2/ADCY7/MCOLN3/ATP2A2/NFATC3/FGFR2/PDGFD/SLC25A4/PPP3CA/ERBB3/CALM2/EDNRB	-1.02849108047152
Organismal Systems	Immune system	hsa04611	Platelet activation	10/996	126/9376	0.747115445910627	ITGB1/GNAQ/ROCK1/ITPR2/ADCY7/ROCK2/PPP1R12A/PRKCI/PIK3R3/TLN1	-0.985212715161809
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/996	70/9376	0.672403901319564	CBR1/MGST3/GSTK1/GSTM3/MGST2	-0.948417404459399
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/996	95/9376	0.693637708729655	FOS/JUN/CTSL/ATP6V1B1/ATP6V1H/ATP6V1C2/ANGPT1	-1.03464895473962
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/996	20/9376	0.470682730923695	NPL	-0.81691948054964
NA	NA	hsa04382	Cornified envelope formation	18/996	217/9376	0.780856143467881	ITGB4/ITGA6/LAMA5/DST/KRT80/COL4A2/DSG2/CLDN4/KRT7/TJP1/PLEC/FURIN/SPTLC3/OCLN/COL4A1/ST14/KDSR/EPHX2	-1.12597419029334
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/996	48/9376	0.588353413654618	G6PC3/ATP1A1/PIK3R3	-0.985698660490646
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/996	36/9376	0.522980812137439	GUSB/DCXR	-0.988568935140406
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	8/996	110/9376	0.684629426798101	CPEB4/KRAS/IGF1R/ADCY7/ANAPC5/MAPK8/PIK3R3/ANAPC1	-1.1470032809956
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/996	99/9376	0.665611942720376	GNAQ/CAMK2G/ITPR2/ADCY7/MAPK8/PIK3R3/CALM2	-1.1530758469974
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	14/996	181/9376	0.728127981539417	HSPD1/CAMK2G/BCL2/CASP3/KSR1/EEA1/ATP6V1H/IL10RB/MAPK8/EP300/LAMP1/PPP3CA/CALM2/PLA2R1	-1.27327212166769
Cellular Processes	Cell motility	hsa04814	Motor proteins	15/996	194/9376	0.727859893180971	MYH10/KIF5B/HOOK3/DYNLL2/DYNC1H1/MYO7A/MYO1C/MYO5B/KIF3A/DYNC1LI2/MYO9A/KIF13B/DYNC1LI1/KIFC3/DNAH14	-1.32043816922139
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/996	41/9376	0.4592026643158	GABRE/GABRA4	-1.19636199597556
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/996	69/9376	0.545719108317327	HRAS/KRAS/MAPK8/PIK3R3	-1.30568211743156
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/996	26/9376	0.362063639172073	HES1	-1.12292699732826
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/996	72/9376	0.522980812137439	ADAR/IRF3/MAP3K1/MAPK8	-1.40074971935021
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/996	29/9376	0.324608779947376	CALM2	-1.25577428705058
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/996	100/9376	0.564819277108434	CSF3R/ITGA6/TFRC/CD55/CD24/MME	-1.50828210147208
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/996	46/9376	0.409289331237995	GUSB/HMOX2	-1.38454223004744
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/996	88/9376	0.534866739686017	F5/CD46/CD55/SERPINB2/TFPI	-1.51130084980253
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	11/996	168/9376	0.616370242876267	GLUL/PARP1/CAMK2G/BCL2/TRPM7/DNM1L/CFLAR/GLUD1/HMGB1/MAPK8/SLC25A4	-1.72972702372988
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/996	50/9376	0.376546184738956	LRP1/MET	-1.52382425372936
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	13/996	193/9376	0.634080362902387	GNAQ/ROCK1/GNG12/HRAS/KRAS/GSK3B/ADCY7/ROCK2/PARD3/GNG5/PIK3R3/TIAM1/PTK2	-1.77078313459484
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/996	82/9376	0.4592026643158	LGMN/HSPA8/CTSL/PDIA3	-1.69563914321145
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	11/996	173/9376	0.598556074007011	CDK6/CASP3/PABPN1/XPO1/KPNA6/ADAR/IRF3/DNAJB1/PIK3R3/SLC25A4/EP300	-1.83728500222336
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/996	37/9376	0.254423097796592	GNAQ	-1.56652170860659
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/996	38/9376	0.247727753117734	PNP	-1.60189188595659
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/996	78/9376	0.362063639172073	ITGB1/FOS/JUN	-1.9503977403012
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/996	109/9376	0.43181901919605	FOS/JUN/IRF3/MAPK8/PIK3R3	-2.05694963350654
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/996	44/9376	0.213946695874407	HSPD1	-1.80170742720606
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/996	63/9376	0.298846178364251	CBR1/EPHX2	-1.9250059528207
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/996	46/9376	0.204644665618998	PSMD1	-1.86420037181971
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/996	66/9376	0.285262261165876	JUN/SMAD2	-2.00880203306993
NA	NA	hsa04082	Neuroactive ligand signaling	11/996	199/9376	0.520352767855341	ADRB1/GABRE/SLC6A4/GNAQ/GNG12/P2RY6/ADCY7/GNG5/OGFRL1/GLRB/GABRA4	-2.35771557869649
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	10/996	187/9376	0.503403990292722	JUN/ANTXR2/PKN2/ITPR2/BCL2/TRPM7/DNM1L/IRF3/NEK7/MAPK8	-2.36473893033302
Human Diseases	Substance dependence	hsa05034	Alcoholism	10/996	191/9376	0.492861498349419	SLC29A3/MAOA/FOSB/GNG12/HRAS/KRAS/GNG5/SLC29A1/CALM2/CREB3L2	-2.44116415632993
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	13/996	238/9376	0.514191218656137	EGFR/FOS/RPS21/JUN/IL6ST/NRP1/ADAR/IRF3/MAPK8/PIK3R3/RPL22L1/RPL26L1/RPL36AL	-2.61710749069258
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/996	133/9376	0.353896790168192	HRAS/KRAS/CASP3/PIK3R3/PPP3CA	-2.58710789134791
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	8/996	180/9376	0.418384649709951	BCL2/CASP3/PDIA3/SRSF6/SRSF7/IRF3/SRSF2/PIK3R3	-2.71622617176326
Genetic Information Processing	Translation	hsa03010	Ribosome	11/996	222/9376	0.466442345960418	RPS21/MRPL33/MRPL1/MRPS26/MRPS10/MRPL16/MRPS5/MRPS33/RPL22L1/RPL26L1/RPL36AL	-2.77361185962861
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/996	86/9376	0.218922200429625	KCNK5/GABRA4	-2.50858580716195
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/996	66/9376	0.142631130582938	HSD17B1	-2.40967313519115
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	7/996	183/9376	0.360085149340532	NOP56/XRN2/XPO1/LSG1/UTP14C/POP5/WDR43	-3.01378593654521
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/996	100/9376	0.188273092369478	IL6ST/IL10RB	-2.8133442077292
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	13/996	298/9376	0.410662785369667	CSF3R/LIFR/BMP7/IL6ST/GHR/BMP4/PRLR/IL10RB/BMPR1A/TGFBR2/GDF15/ACVR2B/TNFRSF21	-3.56426681475601
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/996	195/9376	0.241375759448049	HMGB1/PIK3R3/SLC25A4/CLCN5/CLCN3	-3.69056047134576
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/996	143/9376	0.0658297525767405	ACTN4	-3.88075236021075
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/996	370/9376	0.330750027135569	ADRB1/GABRE/APELA/NR3C1/GHR/P2RY6/PRLR/S1PR2/EDN1/OGFRL1/GLRB/GABRA4/EDNRB	-4.52810564777285
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/996	449/9376	0.0419316464074561	CAMK2G/CALM2	-7.17232889222995