category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	63/1060	174/9376	3.20260247234873	RRBP1/GANAB/HSP90B1/HSPA5/LMAN1/P4HB/CKAP4/RPN2/MOGS/MAN1B1/MAN1A2/OS9/SIL1/SEL1L/SEC62/SEC61A1/EDEM3/DDIT3/ATF6B/ERP29/CANX/PDIA4/UGGT1/PDIA3/STT3B/WFS1/MBTPS1/AMFR/ATF6/PRKCSH/UGGT2/ERO1B/TUSC3/PPP1R15A/XBP1/STT3A/DDOST/HSPA1A/HYOU1/UBE2G2/UBE4B/CALR/SYVN1/RPN1/DNAJC3/BCL2/MAGT1/DNAJB11/MAN1C1/DNAJC10/EDEM2/SEC24D/LMAN2/DNAJB2/SEC63/NPLOC4/SSR1/MBTPS2/DNAJB1/SEC31A/SEC24A/ERLEC1/HSPA1B	10.4701032039993
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	75/1060	250/9376	2.65358490566038	GAA/PSAP/CTSD/NAGLU/CTSL/HEXA/MANBA/GNS/GUSB/ATP6AP1/CTSA/CTSC/LGMN/MCOLN3/CTSF/GLB1/TPP1/SLC38A9/NEU1/VPS13A/SUMF1/SLC17A5/VPS13C/ASAH1/PLA2G15/CTSV/SMPD1/SGSH/GNPTAB/ATP6V1B1/SLC11A2/ABCA5/NPC1/CLTC/SLC29A3/FUCA1/IGF2R/ARSA/HGSNAT/GLA/CTSO/HYAL2/LIPA/LAMP2/LAMP1/CTSB/ACP2/CLN5/TMEM175/HEXB/AP3D1/SORT1/SCARB2/SLC29A2/ATP6V0A1/NAGPA/CLCN7/TCIRG1/GM2A/MFSD8/TLR3/PPT1/CLN6/PIKFYVE/ATP6V1E2/NAGA/CLN8/DNASE2/AP2A2/ATP6V0B/PPT2/SLC15A4/SPG11/CTBS/IDS	9.46101218694614
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	26/1060	56/9376	4.10673854447439	GANAB/RPN2/MOGS/MAN1B1/MAN1A2/MAN2A1/STT3B/MGAT1/TUSC3/ALG8/FUT8/B4GALT1/STT3A/DDOST/MGAT3/DPAGT1/RPN1/DPM3/ALG10B/MAGT1/ALG2/MAN1C1/ALG6/DOLPP1/MAN2A2/DOLK	8.32476712420094
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	47/1060	184/9376	2.25939294503692	SEMA6D/SEMA6A/MET/ITGB1/PLXNB1/PLXNA1/EPHB4/SEMA3F/NRP1/EFNA5/PLXNB2/NFATC3/ROCK1/PLXNA2/SEMA4C/BMPR2/RASA1/SEMA4B/BMP7/SEMA7A/EPHA2/SRGAP1/PAK6/CAMK2G/FZD3/SEMA3B/ARHGEF12/PIK3R3/SEMA3E/EPHA1/ROBO1/UNC5B/PRKCZ/LRIG2/NTN4/SEMA4G/PARD3/PPP3CA/PIK3CA/LIMK2/PTCH1/RAC3/EFNA1/EPHB3/KRAS/NFATC2/WNT4	6.15951461845684
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	49/1060	203/9376	2.13506831489915	LAMA5/COL4A2/ITGB4/EGFR/LAMB1/LAMC1/FN1/JUN/ITGAV/ITGA6/MET/ITGB1/COL4A1/ITGB5/IGF1R/ITGB8/FLT1/DIAPH1/FLNB/VCL/ROCK1/XIAP/ARHGAP5/LAMB2/PAK6/ACTN4/ITGA3/BCL2/PPP1R12B/PDGFD/PIK3R3/SHC1/SPP1/ITGB6/LAMB4/ERBB2/COL1A1/COL1A2/PIP5K1A/CRKL/COL6A1/RAPGEF1/PIK3CA/RAC3/AKT2/PXN/BRAF/PPP1R12A/LAMA1	5.83708010455112
NA	NA	hsa04518	Integrin signaling	40/1060	154/9376	2.29747610879686	FBN1/LAMA5/COL4A2/ITGB4/EGFR/LAMB1/LAMC1/FN1/ITGAV/CDH1/ITGA6/FRAS1/MET/ITGB1/COL4A1/ITGB5/IGF1R/ITGB8/FLT1/FLNB/FREM2/VCL/FERMT1/LAMB2/ACTN4/ITGA3/PDGFD/PIK3R3/SPP1/ITGB6/LAMB4/ERBB2/COL1A1/COL1A2/COL6A1/PIK3CA/RAC3/AKT2/PXN/LAMA1	5.79600166622368
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	12/1060	21/9376	5.0544474393531	CHPF/CHST12/B3GAT3/XYLT1/CHPF2/CHST14/DSE/B4GALT7/CHSY1/XYLT2/CHST11/B3GALT6	6.64049962758567
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	18/1060	44/9376	3.61852487135506	HEXA/RPN2/MAN1B1/MAN1A2/MAN2A1/STT3B/MGAT1/TUSC3/FUT8/B4GALT1/STT3A/DDOST/HEXB/RPN1/MAGT1/ALG2/MAN1C1/MAN2A2	6.21551339837078
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	20/1060	55/9376	3.21646655231561	PSAP/PLPP3/HEXA/GLB1/NEU1/ASAH1/SMPD1/ARSA/GLA/DEGS1/SAMD8/HEXB/SPTLC3/GM2A/SMPD4/B4GALT5/SGPP1/CERS6/CERS5/GBA2	5.88562520929547
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	66/1060	333/9376	1.75311915689274	LAMA5/COL4A2/ITGB4/EGFR/LAMB1/LAMC1/FN1/ITGAV/ITGA6/ITGB1/COL4A1/ITGB5/ITGB8/ATP6AP1/NOTCH3/JAG1/CREB3L2/TCF7L2/CDK6/MAML2/ATP6V1B1/DLG1/UBR4/FZD10/FZD6/HES1/PRKCI/LAMB2/ITGA3/ATP6V0A1/FZD3/RFNG/TCIRG1/SCRIB/PIK3R3/DLG2/SPP1/ITGB6/TLR3/LAMB4/NOTCH2/HLA-C/TNFRSF1A/COL1A1/COL1A2/PRKCZ/HLA-E/CHD4/HLA-G/TSC2/ATP6V1E2/COL6A1/DVL3/ATR/FZD5/PARD3/ATP6V0B/PIK3CA/APC/AKT2/PXN/KRAS/PSEN1/CREB5/LAMA1/WNT4	4.99586709829654
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	26/1060	89/9376	2.58401526393894	LAMA5/COL4A2/ITGB4/LAMB1/LAMC1/FN1/DAG1/ITGAV/ITGA6/FRAS1/ITGB1/COL4A1/ITGB5/ITGB8/FREM2/HSPG2/LAMB2/ITGA3/SPP1/ITGB6/LAMB4/COL1A1/COL1A2/COL6A1/SDC1/LAMA1	5.36040956279293
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	50/1060	233/9376	1.89812940319054	FBN1/FBN2/COL4A2/ITGB4/FN1/DAG1/ITGAV/ITGA6/FBLN1/PLEC/ITGB1/SPTBN1/COL4A1/ITGB5/SYNE2/DSG2/SPTAN1/ITGB8/DSC2/MYH10/DIAPH1/ANK3/VCL/ATP1A1/DAAM1/BGN/HSPG2/DMD/COL5A2/SSPN/INF2/FMNL2/DIAPH2/SGCE/SUN1/SUN2/ITGA3/COL3A1/ITGB6/COL1A1/COL1A2/DSP/COL6A1/VIM/TMEM43/LBR/SDC1/JUP/PKP2/LAMA1	4.95625731676832
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	10/1060	19/9376	4.65541211519364	NAGLU/HEXA/GNS/GUSB/GLB1/SGSH/HGSNAT/HYAL2/HEXB/IDS	5.69411407037293
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	36/1060	157/9376	2.02821776228819	CDH1/DLG5/TCF7L2/SERPINE1/DLG1/BMPR2/TEAD1/FRMD6/BMP7/LATS2/FZD10/FZD6/AMOT/RASSF6/TGFBR1/PRKCI/BMP4/FZD3/SCRIB/DLG2/ID1/WWC1/PRKCZ/TGFBR2/LATS1/TEAD3/BMPR1A/DVL3/FZD5/PARD3/YAP1/ID2/APC/FBXW11/SMAD7/WNT4	4.63846571821011
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	18/1060	62/9376	2.56798539257456	NCSTN/TLE4/NOTCH3/JAG1/MAML2/TLE1/HES1/ADAM17/RFNG/NOTCH2/DTX4/SPEN/DTX2/DVL3/CTBP1/ATXN1/PSEN1/APH1A	4.4223292245137
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	32/1060	144/9376	1.96561844863732	IL6ST/IGF1R/ZFHX3/LIFR/TBX3/BMPR2/RIF1/ID4/FZD10/FZD6/JARID2/FGFR2/SMAD5/ACVR2B/BMP4/FZD3/ACVR2A/PIK3R3/REST/ID1/ISL1/BMPR1A/DVL3/FZD5/ID2/PIK3CA/APC/AKT2/KRAS/DUSP9/WNT4/ID3	4.16888805341825
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	10/1060	24/9376	3.68553459119497	EXTL2/B3GAT3/XYLT1/HS6ST2/EXT2/B4GALT7/XYLT2/EXT1/B3GALT6/GLCE	4.70289684612616
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	26/1060	110/9376	2.09070325900515	FBN1/LTBP1/TFRC/ROCK1/BMPR2/BMP7/ZFYVE16/ID4/SMAD5/TGFBR1/LEMD3/ACVR2B/BMP4/ACVR2A/ID1/SIN3A/TGFBR2/BMPR1A/RGMB/HAMP/BAMBI/ID2/NCOR1/SMAD7/SKI/ID3	4.10807284479946
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	23/1060	93/9376	2.18754311219314	EGFR/CDH1/MET/PTPRF/IQGAP1/IGF1R/LMO7/PTPRM/TCF7L2/VCL/CTNND1/INSR/ROCK1/SORBS1/TGFBR1/PTPRJ/ACTN4/BAIAP2/ERBB2/WASF2/TGFBR2/PARD3/RAC3	4.10892311200688
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	15/1060	49/9376	2.70773969965345	GALNT11/C1GALT1/GXYLT1/B4GALT1/GALNT18/C1GALT1C1/GALNT6/RFNG/OGT/PLOD3/POGLUT1/GALNT2/XXYLT1/POFUT1/GALNT7	4.27887950429298
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	11/1060	30/9376	3.24327044025157	GPAA1/PGAP1/PIGT/PIGQ/PIGO/PIGG/PIGM/PGAP3/PIGV/PIGS/PIGL	4.39350073273476
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	40/1060	204/9376	1.73436921938587	EGFR/FN1/ITGAV/CTSL/MET/ITGB1/IQGAP1/ITGB5/IGF1R/GPC1/ERBB3/SLC9A1/GPC3/TIMP3/ANK3/ITPR2/ROCK1/HSPG2/FZD10/FZD6/CAMK2G/FZD3/GAB1/PPP1R12B/ARHGEF12/PIK3R3/ERBB2/COL1A1/COL1A2/FZD5/PLAU/PIK3CA/SDC1/PTCH1/AKT2/PXN/KRAS/BRAF/PPP1R12A/WNT4	3.78598471774467
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	8/1060	18/9376	3.93123689727463	HEXA/MANBA/GLB1/NEU1/FUCA1/MAN2B2/HEXB/GBA2	4.44402999323748
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	15/1060	52/9376	2.55152394775036	LRP2/LRP1/APOE/ABCA1/LRPAP1/APOC1/NCEH1/LDLR/NPC1/LIPA/SORT1/LCAT/LIPG/MYLIP/STARD3	4.00534890351222
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	21/1060	86/9376	2.1598946906538	ITGB4/DAG1/ITGAV/ITGA6/ITGB1/ITGB5/DSG2/GJA1/ITGB8/DSC2/TCF7L2/ATP2A2/DMD/SSPN/SGCE/ITGA3/ITGB6/DSP/JUP/PKP2/LAMA1	3.85781377613674
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	22/1060	93/9376	2.09243254209779	LAMA5/COL4A2/LAMB1/LAMC1/FN1/ITGAV/ITGA6/ITGB1/COL4A1/GADD45B/CDK6/XIAP/LAMB2/ITGA3/BCL2/PIK3R3/LAMB4/GADD45G/PIK3CA/TRAF4/AKT2/LAMA1	3.77983862181164
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	32/1060	157/9376	1.80286023314505	LRP1/ITGAV/SLC2A1/ITGB5/ABCA1/PBX1/BSG/PLA2G15/NFATC3/ADAM10/DNMT3A/ATP2A2/LIPA/CPT1A/XKR8/P2RY6/ANO6/ADAM17/CAMK2G/CALR/RAB5B/ATP11B/TMEM30A/SLC16A1/TMEM30B/ATP11C/CRKL/VPS8/ADAM9/DUSP16/TGFBRAP1/NFATC2	3.62183946294613
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	43/1060	232/9376	1.63942745608328	ITGB4/EGFR/FN1/ITGAV/ITGA6/ITGB1/IQGAP1/ITGB5/IQGAP2/ITGB8/SLC9A1/MYH10/DIAPH1/VCL/ROCK1/GNA12/SCIN/FGFR2/DIAPH2/PAK6/ACTN4/ITGA3/BAIAP2/PPP1R12B/ARHGEF12/PDGFD/PIK3R3/ITGB6/WASF2/PIP5K1A/PIKFYVE/CRKL/PFN2/PIK3CA/APC/LIMK2/NCKAP1/RAC3/AKT2/PXN/KRAS/BRAF/PPP1R12A	3.52085787599492
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	24/1060	108/9376	1.96561844863732	NUP210/RANBP2/THOC2/RANBP17/KPNA6/TNPO1/TMEM33/UPF2/TPR/POM121C/TNPO2/AHCTF1/POM121/IPO7/PNN/NUP155/NUP205/UPF3B/SUMO4/UPF1/DDX39B/NDC1/XPO6/UPF3A	3.60334421103701
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	33/1060	170/9376	1.71702552719201	EGFR/MET/LRP5/GADD45B/IGF1R/TCF7L2/CDK6/MGST3/ARID1A/FZD10/FZD6/TGFBR1/FZD3/ARID1B/GAB1/PIK3R3/SHC1/ARID2/PBRM1/TGFBR2/MGST2/SMARCA2/DVL3/FZD5/GADD45G/SMARCD2/PIK3CA/APC/AKT2/KRAS/BRAF/LRP6/WNT4	3.36825469173335
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	34/1060	178/9376	1.68954844180623	JUN/LGR5/LGR4/ZNRF3/LRP5/RNF43/SERPINF1/TLE4/TCF7L2/NOTUM/DAAM1/NFATC3/TBL1X/SIAH1/FZD10/TLE1/FZD6/CAMK2G/FZD3/APCDD1/DVL3/PRICKLE1/FZD5/BAMBI/PPP3CA/APC/RAC3/FBXW11/CTBP1/PSEN1/LRP6/CHD8/NFATC2/WNT4	3.31596097262257
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	7/1060	17/9376	3.64217536071032	DAG1/NRP2/TFRC/MYH10/PCDH11X/LAMP2/LAMP1	3.89271587170551
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	29/1060	148/9376	1.73319734829169	EGFR/JUN/FOS/LRP5/GADD45B/IGF1R/NOTCH3/JAG1/TCF7L2/CDK6/NCOA3/FZD10/FZD6/HES1/FZD3/PIK3R3/SHC1/ERBB2/NOTCH2/DVL3/FZD5/GADD45G/PIK3CA/APC/AKT2/KRAS/BRAF/LRP6/WNT4	3.20980966846869
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	25/1060	122/9376	1.81255799566966	ITGAV/SLC2A1/SLC9A1/NOTCH3/ATP1A1/MED13/NCOA3/ATP2A2/SLC16A2/MED16/NCOA2/MED12/BMP4/PIK3R3/NOTCH2/SIN3A/TSC2/MED12L/NCOR1/PIK3CA/MED13L/AKT2/KRAS/DIO2/WNT4	3.22515704142177
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	29/1060	150/9376	1.71008805031447	EGFR/CDH1/MET/LRP5/GADD45B/TCF7L2/ABCB1/FZD10/FZD6/FGFR2/TGFBR1/FZD3/GAB1/BCL2/PIK3R3/SHC1/ERBB2/TGFBR2/DVL3/FZD5/GADD45G/PIK3CA/JUP/APC/AKT2/KRAS/BRAF/LRP6/WNT4	3.12991424797646
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	9/1060	28/9376	2.84312668463612	GCNT2/B3GNT3/B3GNT2/B4GALT1/A4GALT/FUT4/ST3GAL6/B3GNT5/B4GALT4	3.48703399369391
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	43/1060	250/9376	1.52138867924528	EGFR/IGF1R/FOLR1/TFRC/LDLR/EEA1/CLTC/KIF5B/IGF2R/ZFYVE16/HSPA1A/FGFR2/GBF1/WIPF2/TGFBR1/PRKCI/CYTH3/WWP1/PSD4/RAB5B/RAB11FIP4/PSD3/MVB12B/HLA-C/SH3GLB2/ARFGEF1/PRKCZ/HLA-E/TGFBR2/HLA-G/PIP5K1A/ACAP3/AP2A2/PARD3/ACAP2/HGS/ARFGEF2/EPN3/IQSEC1/USP8/CHMP6/EPN2/HSPA1B	2.98313357335914
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	29/1060	155/9376	1.65492391965916	ITGAV/CTSL/DYNC1H1/ITGB1/ITGB5/ATP6AP1/TFRC/SEC61A1/CANX/EEA1/ATP6V1B1/COLEC12/OLR1/LAMP2/LAMP1/HLA-DRB1/CALR/RAB5B/ATP6V0A1/TCIRG1/PLA2R1/HLA-C/MSR1/HLA-E/HLA-G/PIKFYVE/ATP6V1E2/HGS/ATP6V0B	2.9352765226278
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	10/1060	36/9376	2.45702306079665	GALNT11/C1GALT1/B3GNT3/GCNT4/GALNT18/C1GALT1C1/GALNT6/GALNT2/B4GALT5/GALNT7	3.12698334658285
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	8/1060	26/9376	2.72162554426705	SLC19A1/SLC19A3/SLC52A3/SLC5A6/LMBRD1/SLC46A1/SLC19A2/ABCD4	3.13834653727956
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	22/1060	115/9376	1.69214109926169	EGFR/FOS/EGR1/LRP5/MMP15/GNAQ/JUND/CREB3L2/MMP14/ATF6B/AKAP13/ITPR2/PDE4B/GNA12/ADCY7/WNK1/GATA3/BCL2/GNA11/BRAF/LRP6/CREB5	2.66621978567769
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	17/1060	82/9376	1.83377818683847	CTSL/HSPA5/LGMN/CD74/CANX/PDIA3/HLA-DRB1/HSPA1A/CTSB/TAPBP/CALR/HLA-C/TAPBPL/HLA-E/B2M/HLA-G/HSPA1B	2.70730665993911
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	14/1060	63/9376	1.96561844863732	GADD45B/TCF7L2/GLI3/PTCH2/FZD10/FZD6/BMP4/FZD3/DVL3/FZD5/GADD45G/APC/PTCH1/WNT4	2.74544253777998
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	28/1060	158/9376	1.5675185096728	CLIP1/LRP5/IGF1R/SLC3A2/SLC38A9/INSR/RICTOR/ATP6V1B1/FZD10/FZD6/FZD3/PIK3R3/TNFRSF1A/FNIP1/FNIP2/TSC2/ATP6V1E2/DVL3/FZD5/PIK3CA/PRR5/LPIN1/NPRL3/AKT2/KRAS/BRAF/LRP6/WNT4	2.56845258448037
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	25/1060	138/9376	1.60240634399781	PTPRF/INSR/FASN/INPPL1/SORBS1/G6PC3/PHKB/PRKCI/IRS2/PDE3B/PIK3R3/SHC1/SOCS1/PHKA2/PRKCZ/TSC2/CRKL/RAPGEF1/PIK3CA/AKT2/KRAS/PRKAR2A/BRAF/SREBF1/PRKAB2	2.54519716934008
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	23/1060	125/9376	1.6275320754717	CTSD/GNAQ/ASAH1/SMPD1/ROCK1/GNA12/ORMDL1/DEGS1/SPTLC3/BCL2/PIK3R3/S1PR2/TNFRSF1A/S1PR3/PRKCZ/FCER1G/SGPP1/PIK3CA/CERS6/RAC3/AKT2/KRAS/CERS5	2.52161004374053
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	16/1060	78/9376	1.81441702951137	INPPL1/ISYNA1/PIK3C2A/IP6K1/PIK3C2B/PIP5K1A/PIKFYVE/SACM1L/PI4K2A/PI4KA/IP6K2/MTMR4/PIK3CA/MINPP1/SYNJ1/CDIPT	2.57858057755267
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	8/1060	29/9376	2.44007807417046	TEAD1/FRMD6/LATS2/RASSF6/WWC1/LATS1/TEAD3/YAP1	2.77287470633365
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	55/1060	362/9376	1.34389659126446	LAMA5/COL4A2/CSF3R/ITGB4/EGFR/LAMB1/LAMC1/FN1/ITGAV/HSP90B1/ITGA6/MET/ITGB1/COL4A1/ITGB5/IGF1R/ITGB8/ERBB3/PRLR/FLT1/PKN2/CREB3L2/EFNA5/CDK6/ATF6B/INSR/FGFR2/EPHA2/G6PC3/GHR/GNG5/LAMB2/CSH2/ITGA3/BCL2/PDGFD/PIK3R3/SPP1/THEM4/ITGB6/LAMB4/ERBB2/COL1A1/COL1A2/TSC2/COL6A1/IL4R/PHLPP1/PIK3CA/EFNA1/MCL1/AKT2/KRAS/CREB5/LAMA1	2.38234530604617
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	19/1060	99/9376	1.69757956927768	EGFR/JUN/FOS/PLPP3/SLC44A5/SLC44A2/PDGFD/SLC44A1/PIK3R3/GPCPD1/WASF2/PIP5K1A/TSC2/SLC22A5/PIK3CA/RAC3/AKT2/KRAS/DGKA	2.49108703822759
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	20/1060	106/9376	1.6689213243147	EGFR/SPINT1/HSP90B1/SLC19A1/IGF1R/FOLR1/CREB3L2/TCF7L2/SLC46A1/FGFR2/BCL2/PDGFD/PIK3R3/ERBB2/PLAU/PIK3CA/AKT2/KRAS/BRAF/CREB5	2.47268865908074
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	16/1060	80/9376	1.76905660377358	EGFR/MET/IGF1R/ERBB3/NF1/FGFR2/GAB1/BCL2/PDGFD/PIK3R3/SHC1/ERBB2/PIK3CA/AKT2/KRAS/BRAF	2.46624701268798
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	17/1060	87/9376	1.72838863587074	EGFR/JUN/FOS/GADD45B/TCF7L2/TGFBR1/BCL2/PIK3R3/PMAIP1/TGFBR2/GADD45G/PIK3CA/APC/RAC3/AKT2/KRAS/BRAF	2.43679860179474
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/1060	101/9376	1.66396413226228	COL4A2/FN1/JUN/EGR1/COL4A1/DIAPH1/SERPINE1/TGFBR1/COL3A1/BCL2/PIK3R3/COL1A1/COL1A2/PRKCZ/TGFBR2/EDN1/PIK3CA/AKT2/KRAS	2.39513323674485
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	46/1060	300/9376	1.35627672955975	EGFR/JUN/FOS/MET/GADD45B/DUSP1/IGF1R/ERBB3/FLT1/JUND/EFNA5/DDIT3/INSR/NFATC3/DUSP6/NF1/GNA12/RASA1/TAOK1/RPS6KA5/HSPA1A/FGFR2/EPHA2/RAPGEF2/TGFBR1/PDGFD/ERBB2/TNFRSF1A/TAOK3/TGFBR2/MAP3K4/MAPKAPK5/MAP3K9/CRKL/GADD45G/PPP3CA/MAP3K1/DUSP16/RAC3/EFNA1/AKT2/KRAS/BRAF/STK4/HSPA1B/DUSP9	2.23914475910637
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	24/1060	137/9376	1.54953863104256	JUN/FOS/CTSD/CTSL/GADD45B/SPTAN1/CTSC/CTSF/DDIT3/ITPR2/CTSV/XIAP/CTSO/CTSB/BCL2/PIK3R3/PMAIP1/TNFRSF1A/GADD45G/PIK3CA/MCL1/AKT2/KRAS/NOL3	2.31327549903933
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/1060	75/9376	1.76905660377358	GADD45B/CDK6/STEAP3/SERPINE1/SIAH1/PPP1R13L/MDM4/BCL2/PMAIP1/TSC2/SESN3/ATR/ZMAT3/GADD45G/SHISA5	2.38729146709451
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	6/1060	20/9376	2.65358490566038	DHCR24/LIPA/DHCR7/MSMO1/TM7SF2/LBR	2.64288168336524
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	19/1060	103/9376	1.63165414911156	COL4A2/COL14A1/SLC38A2/KCNN4/COL4A1/SLC1A5/SLC3A2/DPP4/COL21A1/ATP1A1/MME/COL5A2/PRCP/KCNK5/COL3A1/COL1A1/COL1A2/COL6A1/COL8A1	2.30127842658012
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	19/1060	103/9376	1.63165414911156	LAMA5/COL4A2/LAMB1/LAMC1/FN1/COL4A1/GNAQ/VCL/LAMB2/ACTN4/RAB5B/COL3A1/PIK3R3/LAMB4/COL1A1/COL1A2/GNA11/PIK3CA/LAMA1	2.30127842658012
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	36/1060	227/9376	1.40277616158258	EGFR/ITGAV/GNAQ/CREB3L2/IL10RB/CDK6/ATF6B/AKAP13/ITPR2/NFATC3/ROCK1/PDIA3/GNA12/ADCY7/TAPBP/GNG5/CALR/ARHGEF12/PIK3R3/HLA-C/TNFRSF1A/TAPBPL/HLA-E/B2M/HLA-G/TSC2/CRKL/GNA11/PPP3CA/PIK3CA/RAC3/AKT2/PXN/KRAS/CREB5/NFATC2	2.19316448289705
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	16/1060	83/9376	1.70511479881791	PHC3/JARID2/MGA/HCFC1/MTF2/OGT/FOXK1/LCOR/DCAF7/KDM2A/AUTS2/CBX4/SFMBT2/YAF2/BCORL1/AEBP2	2.30357436966538
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	19/1060	104/9376	1.61596516690856	PLPP3/PLD3/PLA2G15/AGPAT1/SAMD8/LCAT/GPD1L/CDS1/PISD/GPCPD1/PNPLA6/MBOAT7/CEPT1/PTDSS2/ETNK1/LPIN1/LPCAT3/DGKA/CDIPT	2.25510850039239
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/1060	70/9376	1.76905660377358	DAG1/EIF4G1/DMD/HLA-DRB1/ABL2/SSPN/SGCE/CD55/HLA-C/HLA-E/HLA-G/EIF4G3/RAC3/LAMA1	2.30572300207252
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	18/1060	98/9376	1.62464381979207	ITPR2/INPPL1/CDS1/PIK3C2A/PIK3R3/IP6K1/PIK3C2B/PIP5K1A/PIKFYVE/SACM1L/PI4K2A/PI4KA/IP6K2/MTMR4/PIK3CA/SYNJ1/DGKA/CDIPT	2.21921629022592
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/1060	16/9376	2.76415094339623	HEXA/GLA/HEXB/A4GALT/NAGA	2.52138484843596
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	18/1060	99/9376	1.6082332761578	EGFR/JUN/FOS/IGF1R/NOTCH3/JAG1/NCOA3/ADCY7/BCL2/PIK3R3/SHC1/ERBB2/NOTCH2/NCOR1/PIK3CA/AKT2/KRAS/BRAF	2.17202753232051
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	24/1060	142/9376	1.49497741163965	JUN/ITGAV/FOS/HSP90B1/CTSL/DUSP1/GPC1/MGST3/BMPR2/ACVR2B/BMP4/BCL2/ACVR2A/PIK3R3/TNFRSF1A/PRKCZ/MGST2/BMPR1A/SUMO4/EDN1/PIK3CA/SDC1/RAC3/AKT2	2.12185619916693
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	12/1060	59/9376	1.79904061400704	EGFR/CDH1/GADD45B/TCF7L2/PIK3R3/ERBB2/GADD45G/PIK3CA/APC/AKT2/KRAS/BRAF	2.1980529136833
NA	NA	hsa04519	Cadherin signaling	58/1060	404/9376	1.2698673640949	EGFR/CDH1/MET/GABRE/LRP5/NCSTN/DSG2/DSC3/GJA1/IGF1R/FAT1/DSC2/TMC5/TCF7L2/PCDH11X/VCL/CTNND1/DAAM1/ROCK1/ADAM10/CDH3/TEAD1/TAOK1/LATS2/FZD10/FZD6/KRT80/MYO1C/AMOTL2/MPDZ/EVL/ACTN4/FZD3/RERE/ERBB2/TAOK3/WWC1/MYO7A/TMC4/LATS1/TEAD3/DSP/DVL3/VIM/PRICKLE1/FZD5/YAP1/AMOTL1/JUP/APC/NCKAP1/RAC3/PKP2/KRAS/PSEN1/LRP6/APH1A/WNT4	1.97960137932975
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	22/1060	130/9376	1.49689404934688	COL4A2/EGFR/JUN/FOS/COL4A1/CREB3L2/ATF6B/ADCY7/GNG5/TGFBR1/COL3A1/PIK3R3/SHC1/COL1A1/COL1A2/PRKCZ/TGFBR2/EDN1/PIK3CA/AKT2/KRAS/CREB5	2.03676000296871
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	19/1060	109/9376	1.54183832438982	SLC2A1/PTPRF/SLC27A2/SLC27A3/CREB3L2/INSR/CPT1A/G6PC3/IRS2/PIK3R3/SLC27A6/OGT/TNFRSF1A/PRKCZ/PIK3CA/AKT2/SREBF1/CREB5/PRKAB2	2.03139658269345
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	26/1060	160/9376	1.43735849056604	GLG1/ITGAV/CDH1/ITGA6/PTPRF/ITGB1/CLDN4/ITGB8/CADM1/PTPRM/F11R/JAM3/NRCAM/CDH3/NLGN4X/HLA-DRB1/OCLN/HLA-C/HLA-E/NLGN1/HLA-G/CD276/ALCAM/SDC1/CD99L2/NRXN3	1.9920840160242
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	6/1060	23/9376	2.30746513535685	ENPEP/CTSA/LNPEP/ATP6AP2/MME/PRCP	2.24129952046351
NA	NA	hsa03272	Virion - Hepatitis viruses	10/1060	48/9376	1.84276729559748	EGFR/CLDN4/DPP4/TGOLN2/LDLR/HSPG2/LAMP2/LAMP1/OCLN/CD81	2.08985115005882
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	14/1060	75/9376	1.65111949685535	LRP2/HSP90B1/HSPA5/GNAQ/CREB3L2/ATF6B/ATP1A1/CANX/ITPR2/PDIA4/ADCY7/DUOX1/TTF1/CREB5	2.02119325323324
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/1060	42/9376	1.89541778975741	SLC3A2/SLC40A1/TFRC/FTL/STEAP3/SLC11A2/PCBP2/ACSL3/LPCAT3	2.07633677452247
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	25/1060	155/9376	1.42665855143031	EGFR/GNAQ/PBX1/CREB3L2/TCF7L2/CDK6/ATF6B/ITPR2/NCEH1/KMT2A/LDLR/ADCY7/FZD10/FZD6/CAMK2G/FZD3/RASD1/DVL3/GNA11/FZD5/APC/USP8/BRAF/CREB5/WNT4	1.91222337679091
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	19/1060	112/9376	1.50053908355795	LAMA5/LAMB1/LAMC1/ITGA6/ITGB1/IL10RB/LDLR/XIAP/HLA-DRB1/HSPA1A/LAMB2/BCL2/LAMB4/SOCS1/TNFRSF1A/IFNGR1/AKT2/LAMA1/HSPA1B	1.90251926333255
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/1060	70/9376	1.64269541778976	JUN/SLC2A1/MET/EPAS1/PAK6/GAB1/PIK3R3/CRKL/RAPGEF1/PIK3CA/AKT2/KRAS/BRAF	1.9268771646368
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/1060	78/9376	1.58761490082245	FN1/CDH1/MET/ITGB1/VCL/CLTC/GAB1/PIK3R3/SHC1/WASF2/ELMO3/CRKL/PIK3CA/PXN	1.86048709130062
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13/1060	71/9376	1.61955886260962	EGFR/JUN/MET/ATP6AP1/F11R/JAM3/ATP6V1B1/ADAM10/ADAM17/ATP6V0A1/TCIRG1/ATP6V1E2/ATP6V0B	1.87083243151317
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	20/1060	122/9376	1.45004639653573	FOS/GNAQ/CREB3L2/ATF6B/ITPR2/ADCY7/JUNB/GHR/CSH2/IRS2/PIK3R3/SHC1/SOCS1/CRKL/GNA11/MAP3K1/PIK3CA/AKT2/KRAS/CREB5	1.78629748582743
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	15/1060	86/9376	1.54278192189557	EGFR/JUN/ERBB3/ABL2/PAK6/CAMK2G/GAB1/PIK3R3/SHC1/ERBB2/CRKL/PIK3CA/AKT2/KRAS/BRAF	1.80529456044532
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	32/1060	214/9376	1.32265914300829	JUN/FOS/GNAQ/DDB1/ITPR2/NFATC3/PDIA3/TAPBP/GNG5/PAK6/CALR/BCL2/PIK3R3/HLA-C/TNFRSF1A/TAPBPL/HLA-E/B2M/HLA-G/CRKL/ATR/GNA11/PPP3CA/PIK3CA/LIMK2/RAC3/FBXW11/CUL5/AKT2/PXN/KRAS/NFATC2	1.70465716965677
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	26/1060	169/9376	1.36081277213353	CTSD/CTSL/IGF1R/ATG9A/RB1CC1/BIRC6/WDFY3/LAMP2/LAMP1/CTSB/EIF2AK4/IRS2/BCL2/VMP1/PIK3R3/C9orf72/ATG9B/ATG2A/ATG4D/TSC2/NBR1/MTMR4/PIK3CA/ATG14/AKT2/KRAS	1.68984750031593
Human Diseases	Cancer: specific types	hsa05218	Melanoma	13/1060	73/9376	1.57518738692169	EGFR/CDH1/MET/GADD45B/IGF1R/CDK6/PDGFD/PIK3R3/GADD45G/PIK3CA/AKT2/KRAS/BRAF	1.76132947990031
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	13/1060	73/9376	1.57518738692169	EGFR/MET/GADD45B/CDK6/KIF5B/PIK3R3/ERBB2/GADD45G/PIK3CA/AKT2/KRAS/BRAF/STK4	1.76132947990031
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1060	14/9376	2.52722371967655	B3GNT2/FUT8/B4GALT1/B4GALT4	2.04156725091966
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	33/1060	224/9376	1.30309973045822	JUN/FOS/SLC2A1/EGR1/NRP1/CREB3L2/ATF6B/CANX/NFATC3/DLG1/ADCY7/XIAP/HLA-DRB1/TGFBR1/LTBR/CALR/PIK3R3/HLA-C/TNFRSF1A/TRRAP/HLA-E/TGFBR2/B2M/HLA-G/ATR/PPP3CA/MAP3K1/PIK3CA/ZFP36/AKT2/KRAS/CREB5/NFATC2	1.63920354306329
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	26/1060	170/9376	1.35280799112098	JUN/ITGB1/CLDN4/MYH10/ROCK1/F11R/JAM3/DLG1/MARVELD3/AMOT/OCLN/RAPGEF2/AMOTL2/MPDZ/PRKCI/SYNPO/ACTN4/SCRIB/DLG2/ERBB2/PRKCZ/MARVELD2/PARD3/AMOTL1/MAP3K1/PRKAB2	1.657328960139
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	19/1060	119/9376	1.41227207864278	JUN/FOS/JAG1/CREB3L2/MMP14/ATF6B/XIAP/JUNB/RPS6KA5/ADAM17/PIK3R3/TNFRSF1A/TAB3/BAG4/RHBDF1/EDN1/PIK3CA/AKT2/CREB5	1.61585952378571
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	24/1060	157/9376	1.35214517485879	GADD45B/ZFP36L1/CDK6/ITPR2/NFATC3/SERPINE1/HIPK2/TGFBR1/TRPM7/PIK3R3/HLA-C/HLA-E/TGFBR2/HLA-G/TSC2/RAD9A/ATR/GADD45G/PPP3CA/PIK3CA/FBXW11/AKT2/KRAS/NFATC2	1.58858695241816
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	22/1060	142/9376	1.37039596066968	DDB1/UBE4A/SIAH1/BIRC6/HUWE1/XIAP/RHOBTB1/HERC2/HERC1/UBR5/UBE2G2/WWP1/UBE4B/SYVN1/SOCS1/UBA1/UBE2H/KLHL9/UBA6/MAP3K1/FBXW11/CUL5	1.58780369934439
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	15/1060	90/9376	1.47421383647799	IGF1R/CREB3L2/ATF6B/INSR/RB1CC1/ADCY7/IRS2/PIK3R3/TSC2/SESN3/PIK3CA/AKT2/KRAS/CREB5/PRKAB2	1.61384740077789
NA	NA	hsa04517	IgSF CAM signaling	42/1060	299/9376	1.24248122673061	CDH1/NRP2/APP/PTPRF/ITGB1/IQGAP1/SPTBN1/SPTAN1/PLXNA1/NRP1/MYH10/CADM1/LMO7/ANK3/VCL/F11R/PLXNA2/JAM3/SORBS1/NRCAM/NLGN4X/RASA1/RAPGEF2/ERC1/MPDZ/SRGAP1/PRKCI/PAK6/ACTN4/BAIAP2/PPFIA1/PIK3R3/MTSS1/ROBO1/UNC5B/TRIO/NLGN1/PARD3/EPB41L2/PIK3CA/AKT2/PXN	1.52133156925481
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1060	15/9376	2.35874213836478	HEXA/GLB1/HEXB/SLC33A1	1.8801949492082
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	11/1060	62/9376	1.56932440657334	IGF1R/INSR/ADCY7/HSPA1A/IRS2/PIK3R3/PIK3CA/AKT2/KRAS/HSPA1B/PRKAB2	1.60571646479703
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/1060	28/9376	1.89541778975741	HACD3/THEM4/PPT1/ELOVL1/HADHA/PPT2	1.69405190509669
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	16/1060	99/9376	1.42954068991805	ITGB4/DAG1/ITGAV/ITGA6/ITGB1/ITGB5/ITGB8/ATP2A2/DMD/SSPN/SGCE/ITGA3/ITGB6/EDN1/LAMA1/PRKAB2	1.53390852050635
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	13/1060	77/9376	1.49335947071796	EGFR/GADD45B/CDK6/TGFBR1/PIK3R3/ERBB2/TGFBR2/GADD45G/PIK3CA/RAC3/AKT2/KRAS/BRAF	1.5519296793862
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	13/1060	77/9376	1.49335947071796	GADD45B/CDK6/TGFBR1/PIK3R3/SHC1/TGFBR2/CRKL/GADD45G/PIK3CA/CTBP1/AKT2/KRAS/BRAF	1.5519296793862
Organismal Systems	Digestive system	hsa04970	Salivary secretion	15/1060	93/9376	1.42665855143031	ATP2B1/ATP2B4/KCNN4/ADRB1/SLC9A1/GNAQ/ATP1A1/ITPR2/TRPV6/ADCY7/SLC4A2/VAMP2/LYZ/CST3/SLC12A2	1.47624719044495
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	21/1060	139/9376	1.33633772227501	EGFR/JUN/FOS/HSP90B1/CTSD/GNAQ/CREB3L2/ATF6B/ITPR2/NCOA3/ADCY7/HSPA1A/NCOA2/BCL2/PIK3R3/SHC1/PIK3CA/AKT2/KRAS/CREB5/HSPA1B	1.42626044383534
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	10/1060	57/9376	1.55180403839788	HACD3/FASN/CPT1A/CPT2/PPT1/ELOVL1/ACSL3/HADHA/PPT2/ACADVL	1.49182876566178
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	5/1060	23/9376	1.92288761279737	B4GAT1/B4GALT1/FUT4/POMGNT1/B3GALNT2	1.58204414639318
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	17/1060	110/9376	1.36699828473413	EGFR/SLC2A1/IGF1R/FLT1/TFRC/INSR/SERPINE1/EPAS1/LTBR/CAMK2G/BCL2/PIK3R3/ERBB2/EDN1/PIK3CA/IFNGR1/AKT2	1.38227852090535
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	30/1060	212/9376	1.25169099323603	EGFR/CDH1/MET/ITGB1/IGF1R/GNAQ/FLT1/EFNA5/CTNND1/INSR/ADCY7/FGFR2/EPHA2/RAPGEF2/PRKCI/EVL/PDGFD/PIK3R3/ID1/PRKCZ/CRKL/PFN2/RAPGEF1/PARD3/PIK3CA/RAC3/EFNA1/AKT2/KRAS/BRAF	1.32334900539028
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/1060	51/9376	1.56093229744728	ATP6AP1/SEC61A1/PDIA4/ATP6V1B1/ATP6V0A1/TCIRG1/SLC12A2/ATP6V1E2/ATP6V0B	1.43401087515005
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	16/1060	103/9376	1.37402454662026	SMG1/PABPN1/UPF2/PCF11/GSPT2/MSI2/RNMT/CPSF7/PNN/SMG6/UPF3B/UPF1/DDX39B/FUS/WDR82/UPF3A	1.36266756318986
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/1060	37/9376	1.67343192248853	CDH1/GADD45B/TCF7L2/TPR/GADD45G/KRAS/BRAF	1.46529714728779
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	18/1060	120/9376	1.32679245283019	JUN/MAGED1/KIDINS220/RPS6KA5/SORT1/CAMK2G/GAB1/BCL2/PIK3R3/SHC1/CRKL/RAPGEF1/MAP3K1/PIK3CA/AKT2/KRAS/BRAF/PSEN1	1.28627046807095
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	8/1060	45/9376	1.57249475890985	ABCA1/ABCB1/ABCA5/ABCB8/ABCD4/ABCD3/ABCD1/ABCB10	1.37434259823571
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/1060	31/9376	1.71199026171637	HSPA5/SEC62/SEC61A1/TMEM208/SRPRB/SEC63	1.41757673862819
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	16/1060	105/9376	1.34785265049416	ITGB4/DAG1/ITGAV/ITGA6/ITGB1/ITGB5/ADRB1/ITGB8/ATP2A2/ADCY7/DMD/SSPN/SGCE/ITGA3/ITGB6/LAMA1	1.27969951794044
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1060	18/9376	1.96561844863732	LMBRD1/MTR/HCFC1/ABCD4	1.46396811249119
Human Diseases	Cancer: specific types	hsa05214	Glioma	12/1060	76/9376	1.39662363455809	EGFR/GADD45B/IGF1R/CDK6/CAMK2G/PIK3R3/SHC1/GADD45G/PIK3CA/AKT2/KRAS/BRAF	1.23943924222292
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1060	61/9376	1.45004639653573	ATP2B1/ATP2B4/SLC40A1/FTL/ATP1A1/ATP7B/TRPV6/SLC11A2/SLC46A1/TRPM7	1.25896050814394
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	20/1060	138/9376	1.28192507519825	FN1/JUN/FOS/ITGB1/GNAQ/PKN2/NFATC3/ROCK1/WIPF2/BAIAP2/ARHGEF12/PIK3R3/WASF2/PIP5K1A/CRKL/PIK3CA/RAC3/AKT2/PXN/NFATC2	1.19114765392176
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	10/1060	63/9376	1.40401317759808	KMT2C/KMT2A/PLOD1/NSD1/ASH1L/PLOD2/PLOD3/KMT2E/DHTKD1/HADHA	1.1486886618278
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	11/1060	71/9376	1.37039596066968	EGFR/SLC2A1/MET/SLC1A5/FGFR2/PIK3R3/ERBB2/IDH1/PIK3CA/AKT2/KRAS	1.11845510982373
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	9/1060	56/9376	1.42156334231806	LRP2/GLI3/PTCH2/BCL2/GAS1/KIF3A/MEGF8/PTCH1/FBXW11	1.12961441803317
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	23/1060	166/9376	1.22555126165038	ATP2B1/ATP2B4/ADRB1/GNAQ/CREB3L2/ATF6B/ATP1A1/INSR/ITPR2/NFATC3/ROCK1/ATP2A2/GNA12/ADCY7/IRS2/GTF2I/PDE3B/GNA11/PPP3CA/AKT2/PPP1R12A/CREB5/NFATC2	1.04676892189197
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	50/1060	388/9376	1.13985605913246	LRP1/SLC39A10/APP/COX6A1/LRP5/NCSTN/APOE/GNAQ/DDIT3/INSR/ITPR2/RTN4/MT-CO2/SLC11A2/ADAM10/ATF6/RB1CC1/KIF5B/ATP2A2/SLC39A7/MME/XBP1/FZD10/FZD6/MT-ND3/ADAM17/MT-ND6/IRS2/FZD3/PIK3R3/TNFRSF1A/SLC39A13/ATG2A/NDUFB9/DVL3/NDUFA4L2/SLC39A3/FZD5/PSMD1/PPP3CA/PIK3CA/APC/ATG14/AKT2/KRAS/BRAF/PSEN1/LRP6/APH1A/WNT4	1.00449307704514
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	10/1060	65/9376	1.36081277213353	GNAQ/PBX1/CREB3L2/ATF6B/ITPR2/NCEH1/LDLR/ADCY7/GNA11/CREB5	1.04212963934373
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	9/1060	59/9376	1.34928046050528	ADRB1/INSR/ADCY7/PNPLA2/IRS2/PDE3B/PIK3R3/PIK3CA/AKT2	0.960823418044063
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	11/1060	75/9376	1.29730817610063	MGST3/ATP7B/XIAP/REV3L/BCL2/PIK3R3/ERBB2/PMAIP1/MGST2/PIK3CA/AKT2	0.922898611649424
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	13/1060	93/9376	1.2364374112396	JUN/FOS/NOTCH3/JAG1/MAML2/NFATC3/HLA-DRB1/GATA3/NOTCH2/IL4R/PPP3CA/IFNGR1/NFATC2	0.818078210054467
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	19/1060	142/9376	1.18352378421472	JUN/FOSB/FOS/JUND/ITPR2/ATP2A2/JUNB/TYROBP/TGFBR1/PIK3R3/SOCS1/TNFRSF1A/TREM2/TGFBR2/PPP3CA/PIK3CA/IFNGR1/AKT2/NFATC2	0.786724949610588
Organismal Systems	Immune system	hsa04611	Platelet activation	17/1060	126/9376	1.19341120095837	ITGB1/GNAQ/ITPR2/ROCK1/ADCY7/STIM1/PRKCI/COL3A1/ARHGEF12/PIK3R3/COL1A1/COL1A2/PRKCZ/FCER1G/PIK3CA/AKT2/PPP1R12A	0.780328301171675
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/1060	23/9376	1.5383100902379	PCYOX1/HMGCR/ZMPSTE24/RCE1	0.922788772322849
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	12/1060	86/9376	1.23422553751645	SLC2A1/KCNN4/GNAQ/CREB3L2/ATF6B/ATP1A1/ADCY7/PCLO/CAMK2G/VAMP2/GNA11/CREB5	0.779034952599604
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/1060	71/9376	1.24581450969971	FOS/PRLR/SOCS7/PIK3R3/SHC1/SOCS1/PIK3CA/SOCS5/AKT2/KRAS	0.742266448979017
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1060	32/9376	1.38207547169811	GAA/GLB1/GLA/B4GALT1/G6PC3	0.772928039944087
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/1060	32/9376	1.38207547169811	BIRC6/XIAP/BCL2/PMAIP1/TNFRSF1A	0.772928039944087
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	21/1060	163/9376	1.13957633985415	JUN/FOS/ATP6AP1/CREB3L2/DDB1/ATF6B/NFATC3/HSPG2/TGFBR1/BCL2/PIK3R3/TLR3/TGFBR2/MAP3K1/PIK3CA/AKT2/KRAS/BRAF/CREB5/MAVS/NFATC2	0.641780330630096
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	14/1060	105/9376	1.17937106918239	JUN/ATG9A/AMFR/SIAH1/CITED2/HUWE1/MUL1/RAB5B/MON1B/ATG9B/NBR1/RHOT2/USP8/KRAS	0.659880183287607
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/1060	65/9376	1.22473149492017	KCNN4/GNAQ/ITPR2/PIK3R3/SPP1/GNA11/PIK3CA/AKT2/KRAS	0.649088307948445
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/1060	41/9376	1.29443166129774	EGFR/CDH1/RPS6KA5/ERBB2/KRAS/BRAF	0.67452897069458
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	14/1060	107/9376	1.15732675013225	SLC2A1/GNAQ/CREB3L2/ITPR2/CPT1A/G6PC3/PHKB/CAMK2G/PDE3B/PHKA2/PPP3CA/AKT2/CREB5/PRKAB2	0.584331568757781
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/1060	91/9376	1.16641094754302	JUN/FOS/NFATC3/INPPL1/PIK3R3/CD81/PPP3CA/PIK3CA/RAC3/AKT2/KRAS/NFATC2	0.569499000361615
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	17/1060	133/9376	1.13060008511846	EGFR/GADD45B/IGF1R/INSR/G6PC3/TGFBR1/HOMER1/IRS2/PIK3R3/TGFBR2/GADD45G/PIK3CA/AKT2/KRAS/BRAF/STK4/PRKAB2	0.541556950985919
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	15/1060	117/9376	1.13401064344461	BPTF/BAZ2B/ARID1A/RSF1/BAZ2A/ARID1B/BRD9/ARID2/EPC1/TRRAP/PBRM1/CHD4/SMARCA2/BAZ1B/SMARCD2	0.520752677705932
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/1060	101/9376	1.13850177470577	GNAQ/CREB3L2/TCF7L2/ADCY7/FZD10/FZD6/CAMK2G/FZD3/DVL3/FZD5/EDN1/KRAS/WNT4	0.499620668989543
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/1060	93/9376	1.14132684114425	EGFR/JUN/EGR1/GNAQ/MMP14/ITPR2/ADCY7/CAMK2G/MAP3K4/GNA11/MAP3K1/KRAS	0.488993719859226
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/1060	68/9376	1.17069922308546	TCF7L2/DUSP6/PIK3R3/CEBPA/PIK3CA/JUP/AKT2/KRAS/BRAF	0.504358267274544
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1060	19/9376	1.39662363455809	GLDC/OGDH/DHTKD1	0.617829165907892
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/1060	60/9376	1.17937106918239	PIK3R3/PPP3CA/PIK3CA/RAC3/AKT2/PXN/KRAS/NFATC2	0.497616317056872
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/1060	44/9376	1.20617495711835	DYNC1H1/CREB3L2/RAB5B/VAMP2/DCTN5/CREB5	0.489391268494804
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	13/1060	103/9376	1.11639494412896	JUN/FOS/GNAQ/SERPINE1/TGFBR1/CALR/PIK3R3/TNFRSF1A/TGFBR2/GNA11/PIK3CA/IFNGR1/AKT2	0.424056699799607
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	22/1060	180/9376	1.08109014675052	CD74/PDIA3/HLA-DRB1/SRSF6/TAPBP/CALR/HCFC1/BCL2/PIK3R3/TLR3/HLA-C/TNFRSF1A/TAPBPL/HLA-E/B2M/POU2F1/HLA-G/TSC2/PIK3CA/IFNGR1/AKT2/MAVS	0.392180673606789
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/1060	28/9376	1.26361185983827	ATP6V1B1/ATP6V0A1/TCIRG1/ATP6V1E2	0.498730512698545
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1060	12/9376	1.47421383647799	CD46/NPC1	0.586834276328797
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	10/1060	79/9376	1.11965607833771	SLC6A4/ATP6V1B1/CLTC/ATP6V0A1/VAMP2/TCIRG1/SLC1A3/ATP6V1E2/AP2A2/ATP6V0B	0.381292467368347
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	15/1060	122/9376	1.08753479740179	IGF1R/CREB3L2/HMGCR/INSR/FASN/CPT1A/G6PC3/IRS2/PIK3R3/TSC2/PIK3CA/AKT2/SREBF1/CREB5/PRKAB2	0.347437930233102
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	17/1060	140/9376	1.07407008086253	CDH1/EGR1/SLC9A1/GNAQ/NOTCH3/JAG1/ITPR2/SERPINE1/ADCY7/GNG5/TGFBR1/PDE3B/SPP1/APELA/AKT2/KRAS/PRKAB2	0.315243546720338
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	18/1060	149/9376	1.0685576801317	EGFR/PLPP3/INSR/GNA12/ADCY7/AGPAT1/CYTH3/GAB1/PDGFD/PIK3R3/SHC1/FCER1G/PIP5K1A/TSC2/PIK3CA/AKT2/KRAS/DGKA	0.301162100703642
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	14/1060	115/9376	1.07681706316653	FOS/GNAQ/CREB3L2/ITPR2/ADCY7/GNG5/CAMK2G/BCL2/PIK3R3/GNA11/PIK3CA/AKT2/KRAS/CREB5	0.295909568021214
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/1060	98/9376	1.08309587986138	ATP2B1/ATP2B4/GNAQ/CREB3L2/ATF6B/ATP1A1/ITPR2/LDLR/ADCY7/CAMK2G/GNA11/CREB5	0.295220611164316
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/1060	38/9376	1.16385302879841	ATP1A1/INSR/PIK3R3/PIK3CA/KRAS	0.361327210018751
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/1060	90/9376	1.08109014675052	EGFR/JUN/FOS/NFATC3/PIK3R3/PPP3CA/PIK3CA/IFNGR1/AKT2/KRAS/NFATC2	0.27596647861224
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	14/1060	116/9376	1.06753415744958	ITGB1/CLDN4/VCL/CTNND1/ROCK1/F11R/JAM3/ARHGAP5/OCLN/ACTN4/PIK3R3/PIK3CA/CD99L2/PXN	0.26129332644801
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	28/1060	238/9376	1.04062153163152	EGFR/MET/IGF1R/FLT1/EFNA5/INSR/NF1/RASA1/FGFR2/ABL2/EPHA2/GNG5/PAK6/RAB5B/GAB1/PDGFD/PIK3R3/SHC1/PIK3CA/RAC3/EFNA1/RALGAPB/REL/RALGAPA2/AKT2/KRAS/STK4/RASAL2	0.226621195669818
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/1060	47/9376	1.12918506623846	INSR/IRS2/PIK3R3/SOCS1/PRKCZ/PIK3CA	0.31697501068909
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	9/1060	73/9376	1.09051434479194	RANBP2/AFF4/CCNT1/FURIN/SERINC3/ELL/CPSF7/HGS/CHMP6	0.277171557410393
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/1060	30/9376	1.17937106918239	SLC19A1/FOLR1/MTR/SLC46A1	0.351302682790163
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/1060	65/9376	1.08865021770682	PLPP3/GLA/PNPLA2/AGPAT1/LIPG/LPIN1/DGKA/TKFC	0.256046976553158
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	24/1060	205/9376	1.0355453290382	JUN/IL6ST/CREB3L2/CDK6/DDB1/ATF6B/DLG1/SCIN/UBR4/LTBR/ACTN4/SCRIB/PIK3R3/PMAIP1/HLA-C/HLA-E/CHD4/HLA-G/HDAC11/PIK3CA/REL/PXN/KRAS/CREB5	0.183709854453664
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	10/1060	83/9376	1.0656967492612	SLC27A2/CROT/ABCD4/EPHX2/ACSL3/PEX11A/ABCD3/IDH1/ABCD1/PEX26	0.214627955649396
NA	NA	hsa04981	Folate transport and metabolism	4/1060	31/9376	1.14132684114425	SLC19A1/FOLR1/MTR/SLC46A1	0.28138256001835
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	25/1060	216/9376	1.02375960866527	JUN/FOS/HSP90B1/HSPA5/ABCA1/DDIT3/NFATC3/VLDLR/LDLR/ATF6/OLR1/XBP1/HSPA1A/CAMK2G/BCL2/PIK3R3/MIB1/TNFRSF1A/POU2F1/PPP3CA/PIK3CA/AKT2/KRAS/HSPA1B/NFATC2	0.126124585662332
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	21/1060	181/9376	1.0262483060565	CTSD/ATP6AP1/CD74/IL10RB/EEA1/LAMP2/LAMP1/HLA-DRB1/CAMK2G/RAB5B/ATP6V0A1/BCL2/TCIRG1/ARHGEF12/PLA2R1/TNFRSF1A/FCER1G/ATP6V0B/PPP3CA/IFNGR1/AKT2	0.127305167442059
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/1060	32/9376	1.10566037735849	ATG9A/ATG9B/ATG2A/ATG4D	0.213748001169723
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	23/1060	201/9376	1.01214681310429	SPINT1/MET/GADD45B/IGF1R/FLT1/PBX1/DDIT3/KMT2A/DUSP6/CCNT1/FUT8/NFKBIZ/JMJD1C/SIN3A/TGFBR2/CEBPA/GADD45G/ID2/PLAU/NCOR1/JUP/FUS/REL	0.062149647830048
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	11/1060	95/9376	1.0241906653426	JUN/FOS/CTSL/ATP6AP1/FLT1/ATP6V1B1/HLA-DRB1/ATP6V0A1/TCIRG1/ATP6V1E2/ATP6V0B	0.0846045189010138
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/1060	60/9376	1.03194968553459	IGF1R/GNAQ/ITPR2/GNA12/GNA11/KRAS/BRAF	0.088635725478573
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/1060	69/9376	1.0255400601586	JUN/FOSB/FOS/CREB3L2/ATF6B/CAMK2G/PPP3CA/CREB5	0.0760191369647112
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	8/1060	70/9376	1.01088948787062	SLC2A1/CPT1A/G6PC3/IRS2/TNFRSF1A/ACSL3/AKT2/PRKAB2	0.0326479774581979
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1060	52/9376	1.02060957910015	IGF1R/INSR/LDLR/HSD17B1/ADCY7/HSD17B2	0.053204821730471
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/1060	43/9376	1.02852128126371	CPT1A/CPT2/ACSL3/HADHA/ACADVL	0.0669227774424636
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	22/1060	196/9376	0.99283788987293	JUN/FOS/IL6ST/TCF7L2/CDK6/ITPR2/NFATC3/GNG5/PIK3R3/TLR3/HLA-C/TNFRSF1A/HLA-E/HLA-G/PPP3CA/PIK3CA/ATG14/ZFP36/IFNGR1/AKT2/KRAS/NFATC2	-0.0361767059740884
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/1060	53/9376	1.00135279458882	ATP2B1/ATP2B4/GNAQ/ATP1A1/CLTC/AP2A2	0.00352592670842899
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	16/1060	144/9376	0.982809224318658	GNAQ/ITPR2/VLDLR/RB1CC1/PUM1/ATP2A2/XBP1/PIK3R3/PUM2/ATG2A/PSMD1/PIK3CA/CIC/ATG14/AKT2/ATXN1	-0.074218154663547
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	12/1060	109/9376	0.973792625930414	JUN/FOS/IL6ST/NFATC3/HLA-DRB1/GATA3/TGFBR1/TGFBR2/IL4R/PPP3CA/IFNGR1/NFATC2	-0.0982536076352271
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1060	17/9376	1.04062153163152	CSAD/GGT7	0.0598476858373611
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	17/1060	157/9376	0.95776949885831	JUN/FOS/COX6A1/DDIT3/INSR/MT-CO2/XBP1/IRS2/PIK3R3/TNFRSF1A/NDUFB9/CEBPA/NDUFA4L2/PIK3CA/AKT2/SREBF1/PRKAB2	-0.190508994293816
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1060	18/9376	0.982809224318658	FASN/ACSL3	-0.0260628278819535
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	18/1060	168/9376	0.947708894878706	CSF3R/EGFR/IL6ST/PRLR/LIFR/IL10RB/SOCS7/GHR/CSH2/BCL2/PIK3R3/SOCS1/IL4R/PIK3CA/SOCS5/MCL1/IFNGR1/AKT2	-0.244163721840325
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	22/1060	205/9376	0.94924988495168	JUN/GADD45B/CDK6/PDIA3/HLA-DRB1/HES1/TAPBP/CALR/BCL2/PIK3R3/HLA-C/TAPBPL/SIN3A/HLA-E/B2M/HLA-G/VIM/GADD45G/PSMD1/PIK3CA/AKT2/MAVS	-0.262293147969317
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	22/1060	205/9376	0.94924988495168	CTSD/SLC2A1/COX6A1/INSR/MT-CO2/ATP2A2/MT-ND3/TGFBR1/CPT2/CAMK2G/MT-ND6/COL3A1/PIK3R3/COL1A1/COL1A2/PRKCZ/TGFBR2/NDUFB9/PDK4/NDUFA4L2/PIK3CA/AKT2	-0.262293147969317
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/1060	48/9376	0.921383647798742	ATP1A1/G6PC3/PIK3R3/PIK3CA/AKT2	-0.194948801311457
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/1060	105/9376	0.926648697214735	JUN/ITPR2/NFATC3/ARHGEF12/PIK3R3/FCER1G/PPP3CA/PIK3CA/AKT2/KRAS/NFATC2	-0.269848818691646
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	14/1060	133/9376	0.931082423038729	TYROBP/PIK3R3/SHC1/HLA-C/HLA-E/FCER1G/HLA-G/PPP3CA/PIK3CA/RAC3/IFNGR1/KRAS/BRAF/NFATC2	-0.28577923831084
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/1060	39/9376	0.907208514755685	GLDC/MTR/AHCYL1/MAT2A	-0.207308963765826
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/1060	39/9376	0.907208514755685	HLA-DRB1/HLA-C/HLA-E/HLA-G	-0.207308963765826
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	24/1060	226/9376	0.939322090499249	ATP2B1/JUN/FOS/ATP2B4/ADRB1/SLC9A1/CREB3L2/GLI3/ATP1A1/ROCK1/PDE4B/ATP2A2/ADCY7/CAMK2G/PDE3B/PIK3R3/EDN1/PIK3CA/PTCH1/RAC3/AKT2/BRAF/PPP1R12A/CREB5	-0.329651922559087
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1060	49/9376	0.902579899884482	JUN/FOSB/CREB3L2/ATF6B/CREB5	-0.244093915352001
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	14/1060	134/9376	0.924134046747395	GNAQ/MYH10/ADM/ITPR2/ROCK1/GNA12/ADCY7/PPP1R12B/ARHGEF12/PRKCH/GNA11/EDN1/BRAF/PPP1R12A	-0.315789486225891
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/1060	30/9376	0.884528301886792	OGDH/PC/IDH1	-0.226154181487637
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	21/1060	200/9376	0.928754716981132	JUN/FOS/ITGB1/CLDN4/MYH10/ROCK1/GNA12/OCLN/MYO1C/WIPF2/CYTH3/BAIAP2/ARHGEF12/WASF2/TNFRSF1A/MYO6/SEC24D/TAB3/TMED10/NCKAP1/SEC24A	-0.363601563397105
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/1060	88/9376	0.904631217838765	F5/CD46/SERPINE1/SERPINE2/CFD/TFPI/CD55/A2M/PLAU	-0.320898583488278
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/1060	69/9376	0.897347552638775	ADRB1/GNAQ/ITPR2/CTSB/PDE3B/PPP3CA/EDN1	-0.305541584759663
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1060	20/9376	0.884528301886792	CYB5R3/CYB5R1	-0.184555407373292
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/1060	98/9376	0.902579899884482	PLPP3/INPPL1/SCIN/PIK3R3/WASF2/PIP5K1A/CRKL/PIK3CA/LIMK2/AKT2	-0.346111281856219
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/1060	89/9376	0.894466822132711	EGFR/GJA1/ADRB1/GNAQ/ITPR2/ADCY7/PDGFD/GNA11/KRAS	-0.357131063513253
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1060	10/9376	0.884528301886792	SUOX	-0.130430694369528
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/1060	90/9376	0.884528301886792	SLC2A1/SLC9A1/HMGCR/ABCB1/ATP1A1/NCEH1/LDLR/ADCY7/SLC4A2	-0.392973982470583
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/1060	21/9376	0.84240790655885	COASY/CSAD	-0.258109213020992
Human Diseases	Immune disease	hsa05310	Asthma	3/1060	32/9376	0.829245283018868	PRG2/HLA-DRB1/FCER1G	-0.345432037604642
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	10/1060	102/9376	0.867184609692934	ATP2B1/ATP2B4/SLC9A1/GNAQ/ATP1A1/ITPR2/ATP2A2/ADCY7/SLC4A2/SLC12A2	-0.481499980068612
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	26/1060	254/9376	0.905422671222701	ATP2B1/EGFR/MET/ATP2B4/ADRB1/ERBB3/GNAQ/FLT1/MCOLN3/ASPH/ITPR2/NFATC3/STIM2/ATP2A2/ADCY7/STIM1/FGFR2/PHKB/CAMK2G/PDGFD/ERBB2/PHKA2/ORAI3/GNA11/PPP3CA/NFATC2	-0.545557082962635
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/1060	33/9376	0.804116638078902	OGDH/DHTKD1/IDH1	-0.402432155816529
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/1060	33/9376	0.804116638078902	STX16/VAMP2/GOSR1	-0.402432155816529
NA	NA	hsa04382	Cornified envelope formation	22/1060	217/9376	0.896756803756195	LAMA5/COL4A2/ITGB4/ITGA6/PLEC/COL4A1/CLDN4/DSG2/DST/ST14/PRSS8/S100A8/FURIN/KRT80/OCLN/SPTLC3/ELOVL1/EPHX2/DSP/JUP/PKP2/GBA2	-0.549349342500621
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	22/1060	217/9376	0.896756803756195	EGFR/JUN/FOS/HSP90B1/ADRB1/JAG1/CREB3L2/MGST3/ATF6B/KPNA6/ADCY7/XIAP/BCL2/PIK3R3/NOTCH2/MGST2/EPHX2/PAQR7/PIK3CA/AKT2/KRAS/CREB5	-0.549349342500621
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	5/1060	54/9376	0.819007686932215	REV3L/HES1/REV1/ATR/TOP3A	-0.47619386009377
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	4/1060	44/9376	0.804116638078902	GTF2I/TAF3/TAF8/TAF6L	-0.464962419817858
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/1060	44/9376	0.804116638078902	HLA-DRB1/HLA-C/HLA-E/HLA-G	-0.464962419817858
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/1060	34/9376	0.780466148723641	CLOCK/FBXW11/PRKAB2	-0.457828004164047
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	33/1060	323/9376	0.903697645890531	EGFR/MET/ERBB3/ST14/NOTCH3/TIMP3/DICER1/EFNA5/CDK6/SOX4/ABCB1/ROCK1/BMPR2/DNMT3A/RPS6KA5/MDM4/FOXP1/IRS2/FZD3/BCL2/PIK3R3/SHC1/ERBB2/SOCS1/NOTCH2/CRKL/VIM/PLAU/PIK3CA/APC/EFNA1/MCL1/KRAS	-0.628815495287085
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/1060	105/9376	0.84240790655885	GADD45B/XIAP/PPP1R13L/ERC1/LTBR/BCL2/TNFRSF1A/TAB3/GADD45G/PLAU	-0.579758486018064
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1060	12/9376	0.737106918238994	GGCX	-0.325327224808272
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/1060	45/9376	0.786247379454927	HLA-DRB1/HLA-C/HLA-E/HLA-G	-0.513138901846027
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	15/1060	154/9376	0.861553540798824	ATP2B1/ATP2B4/ADRB1/SLC9A1/GNAQ/CREB3L2/ATF6B/ATP1A1/ATP2A2/ADCY7/RPS6KA5/CAMK2G/BCL2/AKT2/CREB5	-0.61845910130621
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	15/1060	154/9376	0.861553540798824	EGFR/JUN/FOS/GNAQ/ITPR2/NFATC3/ROCK1/ADCY7/CAMK2G/PPP1R12B/PPP3CA/KRAS/PPP1R12A/PRKAB2/NFATC2	-0.61845910130621
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/1060	76/9376	0.814697120158888	SLC27A2/SORBS1/OLR1/CPT1A/CPT2/SLC27A6/ACSL3	-0.579067007007504
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/1060	76/9376	0.814697120158888	SLC9A1/GNAQ/ATP1A1/ITPR2/ADCY7/SLC4A2/CAMK2G	-0.579067007007504
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/1060	67/9376	0.792114897212053	GNAQ/ITPR2/CAMK2G/PPP3CA/KRAS/BRAF	-0.609664047869146
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/1060	36/9376	0.737106918238994	GAA/AGL/G6PC3	-0.564206779369049
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1060	13/9376	0.680406386066764	PRKDC	-0.411664661693437
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/1060	69/9376	0.76915504511895	PIK3R3/FCER1G/PIK3CA/RAC3/AKT2/KRAS	-0.687102306484038
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	22/1060	227/9376	0.857252098744909	EGFR/SLC26A2/JUN/FOS/MET/COX6A1/MGST3/MT-CO2/ABL2/MT-ND3/PTPRJ/MT-ND6/PIK3R3/NDUFB9/MGST2/EPHX2/NDUFA4L2/PIK3CA/AKT2/KRAS/BRAF/CBR1	-0.777279434340541
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/1060	59/9376	0.749600255836265	CANT1/ENTPD6/NME3/TK2/NT5C3A	-0.688815909474914
NA	NA	hsa04081	Hormone signaling	21/1060	219/9376	0.848177823727061	ITGAV/ADRB1/IGF1R/SLC40A1/GNAQ/PRLR/INSR/SLC16A2/GNA12/ADCY7/GHR/SMAD5/GNG5/CSH2/IRS2/PIK3R3/BMPR1A/GNA11/HAMP/PIK3CA/DIO2	-0.811637292198581
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	24/1060	248/9376	0.855995130858186	AHNAK/JUN/FOS/HSP90B1/RHOB/DYNC1H1/TCF7L2/GCC2/KIF5B/CYTH3/RAB5B/BCL2/PIK3C2A/TNFRSF1A/MYO6/PIK3C2B/TAB3/PFN2/DCTN5/PIK3CA/NCKAP1/FHOD1/AKT2/SNX18	-0.820533906840695
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/1060	27/9376	0.655206149545772	HACD3/ELOVL1	-0.640530986425581
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	11/1060	122/9376	0.797525518094649	JUN/FOS/NFATC3/DLG1/PAK6/PIK3R3/PPP3CA/PIK3CA/AKT2/KRAS/NFATC2	-0.803649714242363
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/1060	50/9376	0.707622641509434	AOC1/ALDH18A1/ALDH4A1/OAT	-0.740052219091254
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/1060	50/9376	0.707622641509434	LRP1/MET/CD81/SDC1	-0.740052219091254
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/1060	133/9376	0.798070648318911	FOS/GNAQ/CREB3L2/ATF6B/ITPR2/KIF5B/GNG5/CAMK2G/CLOCK/PPP3CA/AKT2/CREB5	-0.837336697842013
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1060	28/9376	0.631805929919137	MOCS1/CBR1	-0.696590879699603
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	8/1060	94/9376	0.752790044158972	JUN/FOSB/FOS/HSP90B1/JUND/S100A8/TAB3/TRAF4	-0.859984120831963
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/1060	63/9376	0.702006588799042	PTGES2/PTGES/EPHX2/LTC4S/CBR1	-0.847253683112426
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	14/1060	156/9376	0.793807450411224	EGFR/CLDN4/CDK6/LDLR/OCLN/PIK3R3/TLR3/TNFRSF1A/CD81/PIK3CA/AKT2/KRAS/BRAF/MAVS	-0.927152423595846
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	22/1060	235/9376	0.82806904857487	COX6A1/CREB3L2/MT-CO2/ADCY7/ARID1A/CPT1A/PNPLA2/MT-ND3/CPT2/MT-ND6/ARID1B/NDUFB9/TSC2/SMARCA2/COX19/KDM3B/ACSL3/NDUFA4L2/SMARCD2/KRAS/CREB5/PRKAB2	-0.952955176779574
Human Diseases	Infectious disease: viral	hsa05162	Measles	12/1060	136/9376	0.780466148723641	JUN/FOS/CD46/CDK6/HSPA1A/ADAR/BCL2/PIK3R3/PIK3CA/AKT2/MAVS/HSPA1B	-0.920696082708052
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	10/1060	116/9376	0.762524398178269	SLC38A2/GNAQ/SLC38A1/ITPR2/ADCY7/SHANK2/GNG5/HOMER1/SLC1A3/PPP3CA	-0.918806013039727
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	14/1060	158/9376	0.783759254836398	GADD45B/ATRX/CDK6/PRKDC/NIPBL/PDS5A/CDKN1C/MAU2/MCM6/DBF4B/MCM2/PDS5B/ATR/GADD45G	-0.978653720220744
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/1060	42/9376	0.631805929919137	AOC1/DHTKD1/HADHA	-0.853785681516466
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	12/1060	138/9376	0.76915504511895	COX6A1/ATP6AP1/ATP6V1B1/MT-CO2/MT-ND3/MT-ND6/ATP6V0A1/TCIRG1/NDUFB9/ATP6V1E2/NDUFA4L2/ATP6V0B	-0.975331570747571
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1060	17/9376	0.52031076581576	MTR	-0.706725951336269
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/1060	54/9376	0.655206149545772	MTR/DNMT3A/AHCYL1/MAT2A	-0.907158496410294
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1060	54/9376	0.655206149545772	HLA-DRB1/HLA-C/HLA-E/HLA-G	-0.907158496410294
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/1060	43/9376	0.617112768758227	PLPP3/ABCA1/AGPAT1	-0.898412547635287
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/1060	31/9376	0.570663420572124	CSAD/HADHA	-0.854811618591492
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/1060	31/9376	0.570663420572124	GLDC/ACSS1	-0.854811618591492
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/1060	66/9376	0.670097198399085	JUN/HLA-DRB1/GATA3/IL4R/IFNGR1	-0.960206101836762
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	9/1060	110/9376	0.723704974271012	IGF1R/ADCY7/PDE3B/PIK3R3/CPEB4/PIK3CA/AKT2/KRAS/BRAF	-1.04064976700053
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/1060	32/9376	0.552830188679245	ACSS1/HADHA	-0.904612076379006
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/1060	100/9376	0.707622641509434	CSF3R/ITGA6/TFRC/MME/HLA-DRB1/ITGA3/CD55/IL4R	-1.04940879251013
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/1060	56/9376	0.631805929919137	CLK4/HSPA1A/CLK1/HSPA1B	-0.986606966133826
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	12/1060	144/9376	0.737106918238994	TCF7L2/FASN/CPT1A/TNFRSF1A/TAB3/TRA2B/LPIN1/AKT2/TRA2A/SREBF1/ACADVL/PRKAB2	-1.134994706684
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/1060	34/9376	0.52031076581576	POLR2J3/POLR2A	-1.00037039130284
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/1060	47/9376	0.564592533119229	ACSS1/PC/HAGH	-1.0683377768595
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/1060	59/9376	0.599680204669012	MGST3/MGST2/GGT7/IDH1	-1.10122574135466
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/1060	82/9376	0.647215830648872	GUSB/MGST3/NME3/TK2/MGST2/CES2	-1.14550242052618
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/1060	36/9376	0.491404612159329	MCM6/MCM2	-1.09151965450503
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	22/1060	253/9376	0.76915504511895	EGFR/JUN/ITGB1/DIAPH1/VCL/ITPR2/ROCK1/RPS6KA5/CYTH3/ACTN4/BCL2/PIK3R3/WASF2/TNFRSF1A/TAB3/CRKL/PFN2/PIK3CA/FBXW11/ATG14/AKT2/PXN	-1.32890256945472
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/1060	22/9376	0.402058319039451	AOC1	-1.00242713950072
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/1060	85/9376	0.624372918978912	CANT1/ENTPD6/NME3/TK2/AK3/NT5C3A	-1.24198530889687
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/1060	97/9376	0.63831939311418	FOS/GNAQ/ADCY7/RPS6KA5/GNG5/CAMK2G/RASD1	-1.27832662066111
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1060	37/9376	0.478123406425293	ALDH4A1/RIMKLB	-1.135533167147
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	14/1060	173/9376	0.715803250081797	CDK6/KPNA6/HLA-DRB1/PABPN1/DNAJC3/ADAR/PIK3R3/TLR3/TNFRSF1A/PIK3CA/DNAJB1/IFNGR1/AKT2/MAVS	-1.34697265160265
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/1060	75/9376	0.589685534591195	MTR/PC/ALDH18A1/IDH1/MAT2A	-1.2736906715182
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/1060	23/9376	0.384577522559475	MLH3	-1.05497734988815
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/1060	23/9376	0.384577522559475	ATP1A1	-1.05497734988815
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/1060	51/9376	0.52031076581576	PLPP3/PLD3/CEPT1	-1.22631480063287
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/1060	87/9376	0.610019518542615	COX6A1/SLC9A1/ASPH/ATP1A1/MT-CO2/ATP2A2	-1.30466600540323
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/1060	38/9376	0.465541211519364	HEXA/HEXB	-1.1785836632248
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	33/1060	368/9376	0.793191140278917	COX6A1/HSPA5/NUP210/DDIT3/RANBP2/MT-CO2/ATF6/RB1CC1/KIF5B/XBP1/MT-ND3/TPR/POM121C/MT-ND6/BCL2/POM121/SETX/C9orf72/TNFRSF1A/ATG2A/NDUFB9/PFN2/CCS/NDUFA4L2/NUP155/NUP205/DCTN5/PSMD1/PPP3CA/SPG11/FUS/ATG14/NDC1	-1.4449745270801
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/1060	99/9376	0.625424051839146	GNAQ/ITPR2/ADCY7/CAMK2G/PIK3R3/PRKCH/PIK3CA	-1.33762703265737
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	23/1060	268/9376	0.759110109828217	SLC39A10/COX6A1/HSPA5/DUSP1/DDIT3/ITPR2/MT-CO2/SLC11A2/ATF6/KIF5B/SLC39A7/XBP1/MT-ND3/GPR37/UBE2G2/CAMK2G/MT-ND6/SLC39A13/UBA1/NDUFB9/NDUFA4L2/SLC39A3/PSMD1	-1.42841956529816
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	44/1060	480/9376	0.810817610062893	APP/COX6A1/HSPA5/LRP5/GNAQ/DDIT3/ITPR2/MT-CO2/ATF6/RB1CC1/KIF5B/ATP2A2/XBP1/FZD10/FZD6/MT-ND3/GPR37/UBE2G2/CAMK2G/MT-ND6/FZD3/BCL2/C9orf72/TNFRSF1A/UBA1/ATG2A/NDUFB9/CCS/DVL3/NDUFA4L2/FZD5/DCTN5/PSMD1/PPP3CA/APC/SPG11/FUS/ATG14/KRAS/BRAF/ATXN1/PSEN1/LRP6/WNT4	-1.51909617311715
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	5/1060	78/9376	0.567005321722303	DHX36/BTG1/BTG2/TOB1/DCP2	-1.37093359683357
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/1060	78/9376	0.567005321722303	JUN/FOS/ITGB1/HLA-DRB1/IFNGR1	-1.37093359683357
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/1060	66/9376	0.536077758719268	STS/HSD17B1/HSD17B2/HSD11B1L	-1.35027942986196
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1060	79/9376	0.559828039168856	MGST3/MGST2/HSD11B1L/CYP2S1/CBR1	-1.40263875720532
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/1060	91/9376	0.583205473771511	GABRE/PDE4B/ADCY7/GNG5/PDE3B/PDE7A	-1.42637290122965
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1060	26/9376	0.340203193033382	HES1	-1.20274181069574
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/1060	115/9376	0.61532403609516	APP/DUSP1/SLC6A4/GNAQ/ITPR2/GNG5/KRAS/BRAF	-1.48182309522114
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1060	68/9376	0.52031076581576	RDH11/DHRS3/RETSAT/CYP2S1	-1.41731887591715
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	15/1060	193/9376	0.687457229445694	GNAQ/ROCK1/ADCY7/GNG5/PIK3R3/SHC1/PRKCZ/CRKL/PARD3/PIK3CA/RAC3/AKT2/PXN/KRAS/BRAF	-1.56630794371335
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1060	27/9376	0.327603074772886	HADHA	-1.24912629740311
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1060	70/9376	0.50544474393531	MGST3/MGST2/HSD11B1L/CBR1	-1.48273537228469
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/1060	44/9376	0.402058319039451	TDG/NEIL1	-1.41931610813052
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/1060	72/9376	0.491404612159329	ADAR/MAP3K1/TKFC/MAVS	-1.54662542526284
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/1060	109/9376	0.568045698459408	JUN/FOS/PIK3R3/SPP1/TLR3/PIK3CA/AKT2	-1.61943231501285
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/1060	46/9376	0.384577522559475	GUSB/FTL	-1.49380111293063
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/1060	46/9376	0.384577522559475	PSMD1/PSME4	-1.49380111293063
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/1060	31/9376	0.285331710286062	H6PD	-1.42290870789641
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1060	31/9376	0.285331710286062	GUSB	-1.42290870789641
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/1060	48/9376	0.368553459119497	HADHA/MCCC2	-1.56582877213362
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/1060	89/9376	0.496926012295951	GABRE/SLC38A2/SLC38A1/ADCY7/GNG5	-1.70243474029118
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	10/1060	149/9376	0.59364315562872	GABRE/GNAQ/ITPR2/ADCY7/MT-ND3/GNG5/MT-ND6/FAAH/NDUFB9/NDUFA4L2	-1.78505574650533
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/1060	63/9376	0.421203953279425	POLR2J3/DDB1/POLR2A	-1.64563062108852
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	18/1060	238/9376	0.668970984620263	EGFR/RPS21/JUN/FOS/IL6ST/NRP1/RPS28/FAU/RPL39/RPS27/CFD/ADAM17/ADAR/PIK3R3/TLR3/TNFRSF1A/PIK3CA/MAVS	-1.84675929867075
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	8/1060	128/9376	0.552830188679245	CANT1/PDE4B/ADCY7/PDE3B/ENTPD6/NME3/AK3/PDE7A	-1.81859034556275
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	7/1060	116/9376	0.533767078724789	GLDC/ACSS1/OGDH/PC/IDH1/H6PD/TKFC	-1.80388051765553
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/1060	50/9376	0.353811320754717	HLA-DRB1/LTBR	-1.63560327822904
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	21/1060	275/9376	0.675457975986278	LAMC1/COX6A1/HSPA5/EGR1/CREB3L2/DDIT3/ATF6B/ITPR2/MT-CO2/KIF5B/HSPA1A/MT-ND3/MT-ND6/PIK3R3/NDUFB9/NDUFA4L2/PSMD1/PPP3CA/PIK3CA/CREB5/HSPA1B	-1.95017713653646
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/1060	35/9376	0.252722371967655	TKFC	-1.5812503956926
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/1060	67/9376	0.396057448606026	ACSS1/G6PC3/MINPP1	-1.77118059748059
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/1060	36/9376	0.245702306079665	GUSB	-1.61883252964102
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/1060	37/9376	0.239061703212647	GNAQ	-1.65569923003395
Cellular Processes	Cell motility	hsa04814	Motor proteins	13/1060	194/9376	0.592725150748882	DYNC1H1/MYH10/KIF5B/MYO1C/MYO9B/KIFC3/KIF3A/KIF21A/MYO7A/MYO6/DCTN5/KIF20B/KIF13B	-2.04645002198989
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/1060	38/9376	0.232770605759682	SIRT7	-1.69188728763931
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	23/1060	308/9376	0.660524381279098	COX6A1/POLR2J3/GNAQ/CREB3L2/MT-CO2/RB1CC1/CLTC/KIF5B/POLR2A/MT-ND3/MT-ND6/SLC1A3/REST/SIN3A/ATG2A/NDUFB9/NDUFA4L2/AP2A2/DCTN5/PSMD1/ATG14/RCOR1/CREB5	-2.16276594009037
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/1060	41/9376	0.215738610216291	GLDC	-1.79670564529182
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/1060	41/9376	0.215738610216291	TOP3A	-1.79670564529182
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1060	41/9376	0.215738610216291	GABRE	-1.79670564529182
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	9/1060	154/9376	0.516932124479294	GUSB/RDH11/DHRS3/COASY/NME3/GGCX/AK3/MOCS1/MAT2A	-2.15792968551338
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	10/1060	168/9376	0.526504941599281	FTL/SMPD1/XIAP/CAMK2G/BCL2/TRPM7/TLR3/TNFRSF1A/IFNGR1/CHMP6	-2.21089830601119
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/1060	78/9376	0.340203193033382	JUN/FOS/ITGB1	-2.08902708308562
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	21/1060	298/9376	0.623325313410156	CSF3R/IL6ST/PRLR/LIFR/IL10RB/BMPR2/BMP7/GHR/TGFBR1/LTBR/CSH2/TNFRSF21/ACVR2B/BMP4/ACVR2A/GDF15/TNFRSF1A/TGFBR2/BMPR1A/IL4R/IFNGR1	-2.35917853932786
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	11/1060	187/9376	0.52031076581576	JUN/PKN2/ANTXR2/ITPR2/XIAP/CTSB/BCL2/TRPM7/DHX33/TAB3/MAVS	-2.36552738208804
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	7/1060	138/9376	0.448673776319387	IGF1R/ITPR2/ADCY7/CAMK2G/CPEB4/PPP3CA/FBXW11	-2.3293810861659
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/1060	83/9376	0.319709024778359	ADAR/DNASE2/MAVS	-2.22247619403592
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/1060	191/9376	0.509414205275116	FOSB/CREB3L2/ATF6B/SLC29A3/SLC29A2/GNG5/SHC1/HDAC11/KRAS/BRAF/CREB5	-2.44553229598878
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/1060	100/9376	0.353811320754717	IL6ST/IL10RB/LTBR/TNFRSF1A	-2.3193180385833
Genetic Information Processing	Transcription	hsa03040	Spliceosome	15/1060	243/9376	0.546005124621477	PRPF38B/RBM25/SF1/THOC2/HSPA1A/SRSF6/PRPF8/SF3B1/TRA2B/CHERP/DDX39B/FUS/TRA2A/PRPF40B/HSPA1B	-2.5599335319973
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/1060	73/9376	0.242336521064875	MGST3/MGST2	-2.32010480694696
NA	NA	hsa04082	Neuroactive ligand signaling	10/1060	199/9376	0.44448658386271	GABRE/ADRB1/SLC6A4/GNAQ/TAC3/ADCY7/P2RY6/GNG5/SLC1A3/GNA11	-2.82782190854659
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/1060	99/9376	0.178692586239756	HLA-DRB1/CFD	-2.93292456219277
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/1060	86/9376	0.102852128126371	KCNK5	-2.98391694283468
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/1060	195/9376	0.272162554426705	CLCN3/CLCN5/PIK3R3/HDAC11/PIK3CA/AKT2	-3.66680688193779
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/1060	143/9376	0.123710252012139	HLA-DRB1/ACTN4	-3.76986381903139
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/1060	183/9376	0.145004639653573	UTP14C/LSG1/TCOF1	-4.17005711523827
Genetic Information Processing	Translation	hsa03010	Ribosome	5/1060	222/9376	0.199218086010539	RPS21/RPS28/FAU/RPL39/RPS27	-4.31088680705616
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/1060	370/9376	0.310780214176441	GABRE/ADRB1/PRLR/ADM/NR3C1/TAC3/P2RY6/GHR/CSH2/S1PR2/S1PR3/EDN1/APELA	-4.82918627565984
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/1060	449/9376	0.0196999621801067	CAMK2G	-7.59995031393145