ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0016758 hexosyltransferase activity 59/2022 197/18639 0.299492385786802 2.76075102803175 1.55825940507392e-13 1.96029033158299e-10 GO:0003712 transcription coregulator activity 105/2022 495/18639 0.212121212121212 1.95535473428649 8.35380365910571e-12 5.25454250157749e-09 GO:0016757 glycosyltransferase activity 67/2022 267/18639 0.250936329588015 2.31315640316074 3.05069343073816e-11 1.27925744528953e-08 GO:0019838 growth factor binding 42/2022 136/18639 0.308823529411765 2.84676645138768 1.66150897619449e-10 5.22544573013168e-08 GO:0008194 UDP-glycosyltransferase activity 41/2022 145/18639 0.282758620689655 2.60649749309322 5.11235761308501e-09 1.28626917545219e-06 GO:0001618 virus receptor activity 28/2022 81/18639 0.345679012345679 3.18650401142983 1.14620716820394e-08 2.40321436266759e-06 GO:0140272 exogenous protein binding 28/2022 82/18639 0.341463414634146 3.14764420641239 1.56160647222715e-08 2.80642991723108e-06 GO:0003714 transcription corepressor activity 50/2022 204/18639 0.245098039215686 2.25933845348228 2.18342090165177e-08 3.43342936784741e-06 GO:0045296 cadherin binding 69/2022 334/18639 0.206586826347305 1.90433820785728 9.48417243318987e-08 1.32567654677254e-05 GO:0005178 integrin binding 41/2022 161/18639 0.254658385093168 2.34746668632619 1.29218734738808e-07 1.6255716830142e-05 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 28/2022 91/18639 0.307692307692308 2.83633873544853 1.94968732337426e-07 2.22973332073165e-05 GO:0019199 transmembrane receptor protein kinase activity 25/2022 78/18639 0.320512820512821 2.95451951609222 3.65336902943341e-07 3.82994853252269e-05 GO:0140416 transcription regulator inhibitor activity 15/2022 33/18639 0.454545454545455 4.19004585918532 4.97305033426851e-07 4.8123825542383e-05 GO:0022804 active transmembrane transporter activity 84/2022 457/18639 0.183807439824945 1.69435552467713 8.36358721317903e-07 7.51528051012801e-05 GO:0017154 semaphorin receptor activity 9/2022 13/18639 0.692307692307692 6.38176215475919 9.73197202917604e-07 8.16188054180231e-05 GO:0050840 extracellular matrix binding 22/2022 67/18639 0.328358208955224 3.02683909827716 1.14159824097923e-06 8.97581616969922e-05 GO:0016798 hydrolase activity, acting on glycosyl bonds 33/2022 130/18639 0.253846153846154 2.33997945674504 2.27337663159515e-06 0.000168229870738041 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 20/2022 60/18639 0.333333333333333 3.0727002967359 2.6651933158171e-06 0.00018626739951655 GO:0008375 acetylglucosaminyltransferase activity 16/2022 43/18639 0.372093023255814 3.4299910289145 5.24030376060573e-06 0.000346963270044316 GO:0140303 intramembrane lipid transporter activity 16/2022 45/18639 0.355555555555556 3.27754698318497 1.03446897608022e-05 0.000632979288405149 GO:0038024 cargo receptor activity 20/2022 65/18639 0.307692307692308 2.83633873544853 1.05664269129635e-05 0.000632979288405149 GO:0015923 mannosidase activity 9/2022 16/18639 0.5625 5.18518175074184 1.14758226083433e-05 0.000656208401877087 GO:0030215 semaphorin receptor binding 11/2022 24/18639 0.458333333333333 4.22496290801187 1.54942051201421e-05 0.000818154379674787 GO:0015924 mannosyl-oligosaccharide mannosidase activity 7/2022 10/18639 0.7 6.4526706231454 1.56086686106478e-05 0.000818154379674787 GO:0015291 secondary active transmembrane transporter activity 55/2022 287/18639 0.191637630662021 1.76653501380287 1.88817489104111e-05 0.000950129605171889 GO:0043236 laminin binding 12/2022 29/18639 0.413793103448276 3.81438657525836 2.27198252733775e-05 0.00106487464635606 GO:0046332 SMAD binding 22/2022 79/18639 0.278481012658228 2.56706607069076 2.28550202318073e-05 0.00106487464635606 GO:0008013 beta-catenin binding 26/2022 106/18639 0.245283018867925 2.26104361457925 4.92197211514523e-05 0.00221137175744739 GO:0005518 collagen binding 20/2022 72/18639 0.277777777777778 2.56058358061325 5.52076639550015e-05 0.00239487038811696 GO:0004559 alpha-mannosidase activity 8/2022 15/18639 0.533333333333333 4.91632047477745 6.02848861582444e-05 0.00252794622623571 GO:0140103 catalytic activity, acting on a glycoprotein 10/2022 23/18639 0.434782608695652 4.00786995226422 6.65718424715429e-05 0.002701528317071 GO:0008238 exopeptidase activity 25/2022 102/18639 0.245098039215686 2.25933845348228 6.90941272327833e-05 0.00271626287683879 GO:0008378 galactosyltransferase activity 12/2022 32/18639 0.375 3.45678783382789 7.24560416947498e-05 0.00276211213490895 GO:0045499 chemorepellent activity 11/2022 28/18639 0.392857142857143 3.62139677829589 8.83089327588071e-05 0.00326743051207586 GO:0003713 transcription coactivator activity 48/2022 256/18639 0.1875 1.72839391691395 0.000108711883631595 0.00381222746480129 GO:0005024 transforming growth factor beta receptor activity 8/2022 16/18639 0.5 4.60905044510386 0.000109093949708145 0.00381222746480129 GO:0051213 dioxygenase activity 23/2022 93/18639 0.247311827956989 2.27974538144922 0.000114618095744983 0.00389701525532942 GO:0090482 vitamin transmembrane transporter activity 12/2022 34/18639 0.352941176470588 3.25344737301449 0.000143113396639365 0.00473780665716634 GO:0004714 transmembrane receptor protein tyrosine kinase activity 17/2022 60/18639 0.283333333333333 2.61179525222552 0.000150077624106991 0.00484096541350243 GO:0070123 transforming growth factor beta receptor activity, type III 7/2022 13/18639 0.538461538461538 4.96359278703492 0.000165991360277296 0.00522042828072097 GO:0008514 organic anion transmembrane transporter activity 49/2022 269/18639 0.182156133828996 1.67913361940587 0.000191965624791617 0.00589006721921595 GO:0140457 protein demethylase activity 11/2022 31/18639 0.354838709677419 3.27093902555758 0.000255963930449609 0.00766672915489543 GO:0002020 protease binding 29/2022 136/18639 0.213235294117647 1.96562445452959 0.000269921369861719 0.00777518018332413 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 9/2022 22/18639 0.409090909090909 3.77104127326679 0.000271945888764914 0.00777518018332413 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 8/2022 18/18639 0.444444444444444 4.09693372898121 0.000303812340435434 0.00830860704929949 GO:0030228 lipoprotein particle receptor activity 8/2022 18/18639 0.444444444444444 4.09693372898121 0.000303812340435434 0.00830860704929949 GO:0031267 small GTPase binding 50/2022 283/18639 0.176678445229682 1.62863973325225 0.000352454438652987 0.00943378050692463 GO:0070577 lysine-acetylated histone binding 9/2022 23/18639 0.391304347826087 3.6070829570378 0.000403972061382082 0.0105874344420554 GO:0030165 PDZ domain binding 20/2022 83/18639 0.240963855421687 2.22122913017053 0.000450501686068313 0.0106714857501442 GO:0051020 GTPase binding 54/2022 315/18639 0.171428571428571 1.58024586689275 0.000450677297590036 0.0106714857501442 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 6/2022 11/18639 0.545454545454545 5.02805503102239 0.000460810621166235 0.0106714857501442 GO:0048185 activin binding 6/2022 11/18639 0.545454545454545 5.02805503102239 0.000460810621166235 0.0106714857501442 GO:0003756 protein disulfide isomerase activity 8/2022 19/18639 0.421052631578947 3.8813056379822 0.000475042290944416 0.0106714857501442 GO:0005520 insulin-like growth factor binding 8/2022 19/18639 0.421052631578947 3.8813056379822 0.000475042290944416 0.0106714857501442 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 8/2022 19/18639 0.421052631578947 3.8813056379822 0.000475042290944416 0.0106714857501442 GO:0046527 glucosyltransferase activity 8/2022 19/18639 0.421052631578947 3.8813056379822 0.000475042290944416 0.0106714857501442 GO:0030246 carbohydrate binding 49/2022 280/18639 0.175 1.61316765578635 0.00050232138750559 0.010722593125013 GO:0030695 GTPase regulator activity 77/2022 489/18639 0.157464212678937 1.45152099907156 0.000502745652602734 0.010722593125013 GO:0005041 low-density lipoprotein particle receptor activity 7/2022 15/18639 0.466666666666667 4.30178041543027 0.00051141143680507 0.010722593125013 GO:0015929 hexosaminidase activity 7/2022 15/18639 0.466666666666667 4.30178041543027 0.00051141143680507 0.010722593125013 GO:0060589 nucleoside-triphosphatase regulator activity 77/2022 490/18639 0.157142857142857 1.44855871131836 0.000534613247122225 0.0110253027029469 GO:0050431 transforming growth factor beta binding 9/2022 24/18639 0.375 3.45678783382789 0.000584521776720658 0.0116718792875331 GO:0140033 acetylation-dependent protein binding 9/2022 24/18639 0.375 3.45678783382789 0.000584521776720658 0.0116718792875331 GO:0035250 UDP-galactosyltransferase activity 10/2022 29/18639 0.344827586206897 3.17865547938197 0.000633110854072358 0.0124445852253598 GO:0042626 ATPase-coupled transmembrane transporter activity 22/2022 98/18639 0.224489795918367 2.06936958759765 0.000683817460203768 0.0131630256686642 GO:0019787 ubiquitin-like protein transferase activity 75/2022 479/18639 0.156576200417537 1.44333521245424 0.000696594398013046 0.0131630256686642 GO:0046915 transition metal ion transmembrane transporter activity 13/2022 45/18639 0.288888888888889 2.66300692383778 0.000717628458734553 0.0131630256686642 GO:0004842 ubiquitin-protein transferase activity 71/2022 449/18639 0.158129175946548 1.45765069756069 0.000724106210998257 0.0131630256686642 GO:0005010 insulin-like growth factor receptor activity 14/2022 51/18639 0.274509803921569 2.53045906790016 0.000798159371346154 0.0131630256686642 GO:0005021 vascular endothelial growth factor receptor activity 14/2022 51/18639 0.274509803921569 2.53045906790016 0.000798159371346154 0.0131630256686642 GO:0140327 flippase activity 7/2022 16/18639 0.4375 4.03291913946587 0.000824325037880457 0.0131630256686642 GO:0000030 mannosyltransferase activity 9/2022 25/18639 0.36 3.31851632047478 0.000826059760125263 0.0131630256686642 GO:0015662 P-type ion transporter activity 9/2022 25/18639 0.36 3.31851632047478 0.000826059760125263 0.0131630256686642 GO:0140358 P-type transmembrane transporter activity 9/2022 25/18639 0.36 3.31851632047478 0.000826059760125263 0.0131630256686642 GO:0005025 transforming growth factor beta receptor activity, type I 6/2022 12/18639 0.5 4.60905044510386 0.000837076354128087 0.0131630256686642 GO:0005026 transforming growth factor beta receptor activity, type II 6/2022 12/18639 0.5 4.60905044510386 0.000837076354128087 0.0131630256686642 GO:0016361 activin receptor activity, type I 6/2022 12/18639 0.5 4.60905044510386 0.000837076354128087 0.0131630256686642 GO:0016362 activin receptor activity, type II 6/2022 12/18639 0.5 4.60905044510386 0.000837076354128087 0.0131630256686642 GO:0017002 activin receptor activity 6/2022 12/18639 0.5 4.60905044510386 0.000837076354128087 0.0131630256686642 GO:0045295 gamma-catenin binding 6/2022 12/18639 0.5 4.60905044510386 0.000837076354128087 0.0131630256686642 GO:0032452 histone demethylase activity 10/2022 30/18639 0.333333333333333 3.0727002967359 0.000858187087209928 0.013328387107532 GO:0015101 organic cation transmembrane transporter activity 19/2022 81/18639 0.234567901234568 2.16227057918453 0.000881049473640417 0.0135165882663371 GO:0051087 protein-folding chaperone binding 27/2022 134/18639 0.201492537313433 1.85737853757917 0.00108004746853704 0.0163698760893928 GO:0061659 ubiquitin-like protein ligase activity 60/2022 372/18639 0.161290322580645 1.48679046616253 0.00110563951352257 0.0165582679525166 GO:0016755 aminoacyltransferase activity 76/2022 496/18639 0.153225806451613 1.41245094285441 0.0012007683085167 0.0177713709660472 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 7/2022 17/18639 0.411764705882353 3.79568860185024 0.00127081542818578 0.0181668841892922 GO:0019198 transmembrane receptor protein phosphatase activity 7/2022 17/18639 0.411764705882353 3.79568860185024 0.00127081542818578 0.0181668841892922 GO:0038191 neuropilin binding 7/2022 17/18639 0.411764705882353 3.79568860185024 0.00127081542818578 0.0181668841892922 GO:0036121 double-stranded DNA helicase activity 13/2022 48/18639 0.270833333333333 2.49656899109792 0.00139188907630809 0.0193115588634126 GO:0005096 GTPase activator activity 46/2022 271/18639 0.169741697416974 1.56469609206478 0.00140977720506971 0.0193115588634126 GO:0031994 insulin-like growth factor I binding 6/2022 13/18639 0.461538461538462 4.25450810317279 0.00141229206314305 0.0193115588634126 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 6/2022 13/18639 0.461538461538462 4.25450810317279 0.00141229206314305 0.0193115588634126 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 14/2022 54/18639 0.259259259259259 2.38987800857237 0.00146871341849498 0.0196557604304967 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 14/2022 54/18639 0.259259259259259 2.38987800857237 0.00146871341849498 0.0196557604304967 GO:0005385 zinc ion transmembrane transporter activity 9/2022 27/18639 0.333333333333333 3.0727002967359 0.0015509466697025 0.0203238636508932 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 9/2022 27/18639 0.333333333333333 3.0727002967359 0.0015509466697025 0.0203238636508932 GO:0042887 amide transmembrane transporter activity 11/2022 38/18639 0.289473684210526 2.66839762611276 0.00178077706590127 0.0230950262773588 GO:0140297 DNA-binding transcription factor binding 74/2022 488/18639 0.151639344262295 1.39782677433478 0.00183338089002402 0.0235346240780635 GO:0017128 phospholipid scramblase activity 7/2022 18/18639 0.388888888888889 3.58481701285856 0.00188618102948145 0.0237281573508767 GO:0034185 apolipoprotein binding 7/2022 18/18639 0.388888888888889 3.58481701285856 0.00188618102948145 0.0237281573508767 GO:0071889 14-3-3 protein binding 10/2022 33/18639 0.303030303030303 2.79336390612355 0.00195255900406321 0.0243199923476388 GO:0141052 histone H3 demethylase activity 9/2022 28/18639 0.321428571428571 2.96296100042391 0.00206815160597471 0.0253355825828271 GO:0005006 epidermal growth factor receptor activity 13/2022 50/18639 0.26 2.39670623145401 0.00208409426584193 0.0253355825828271 GO:0004175 endopeptidase activity 63/2022 405/18639 0.155555555555556 1.43392680514342 0.0020945155712353 0.0253355825828271 GO:0042813 Wnt receptor activity 6/2022 14/18639 0.428571428571429 3.95061466723188 0.00224584682562292 0.0266535406286192 GO:0098821 BMP receptor activity 6/2022 14/18639 0.428571428571429 3.95061466723188 0.00224584682562292 0.0266535406286192 GO:0061630 ubiquitin protein ligase activity 56/2022 353/18639 0.158640226628895 1.46236161431057 0.00231675106570173 0.0272380639313343 GO:0008239 dipeptidyl-peptidase activity 5/2022 10/18639 0.5 4.60905044510386 0.00235626599781384 0.0274461354189797 GO:0051082 unfolded protein binding 24/2022 121/18639 0.198347107438017 1.82838364764451 0.0024719667427656 0.0285296712146709 GO:0008376 acetylgalactosaminyltransferase activity 10/2022 34/18639 0.294117647058824 2.71120614417874 0.00250096817249242 0.0286019814635951 GO:0005030 neurotrophin receptor activity 13/2022 51/18639 0.254901960784314 2.34971199162157 0.00252401936132732 0.0286055527617097 GO:0015932 nucleobase-containing compound transmembrane transporter activity 14/2022 57/18639 0.245614035087719 2.26409495548961 0.00255436967725416 0.0286910451248726 GO:0015297 antiporter activity 26/2022 135/18639 0.192592592592593 1.77533794922519 0.00257841867208823 0.028704873358292 GO:0032451 demethylase activity 11/2022 40/18639 0.275 2.53497774480712 0.00279251858224113 0.0308156875128012 GO:0015294 solute:monoatomic cation symporter activity 23/2022 116/18639 0.198275862068966 1.82772690064463 0.00301972674331808 0.0330331847225578 GO:0019955 cytokine binding 27/2022 144/18639 0.1875 1.72839391691395 0.00319959083085952 0.0346990109070799 GO:0140318 protein transporter activity 11/2022 41/18639 0.268292682926829 2.47314901932402 0.00344862914924195 0.0370801322200545 GO:0061749 forked DNA-dependent helicase activity 12/2022 47/18639 0.25531914893617 2.35355767409559 0.0035933252669323 0.0378972467785509 GO:1990518 single-stranded 3'-5' DNA helicase activity 12/2022 47/18639 0.25531914893617 2.35355767409559 0.0035933252669323 0.0378972467785509 GO:1901505 carbohydrate derivative transmembrane transporter activity 13/2022 53/18639 0.245283018867925 2.26104361457925 0.00363207286535563 0.0378972467785509 GO:0046943 carboxylic acid transmembrane transporter activity 33/2022 188/18639 0.175531914893617 1.61807090094072 0.00364512469014679 0.0378972467785509 GO:0015095 magnesium ion transmembrane transporter activity 7/2022 20/18639 0.35 3.2263353115727 0.00378223717794159 0.0386833688605734 GO:0031418 L-ascorbic acid binding 7/2022 20/18639 0.35 3.2263353115727 0.00378223717794159 0.0386833688605734 GO:0015293 symporter activity 27/2022 146/18639 0.184931506849315 1.70471728791513 0.00389928814158356 0.0389862336884676 GO:0035252 UDP-xylosyltransferase activity 5/2022 11/18639 0.454545454545455 4.19004585918532 0.00393581214502018 0.0389862336884676 GO:0042285 xylosyltransferase activity 5/2022 11/18639 0.454545454545455 4.19004585918532 0.00393581214502018 0.0389862336884676 GO:0048407 platelet-derived growth factor binding 5/2022 11/18639 0.454545454545455 4.19004585918532 0.00393581214502018 0.0389862336884676 GO:0005342 organic acid transmembrane transporter activity 33/2022 189/18639 0.174603174603175 1.60950967924262 0.00396767834777869 0.0389948387617624 GO:0008235 metalloexopeptidase activity 15/2022 66/18639 0.227272727272727 2.09502292959266 0.00408028827020459 0.0397907181699021 GO:0016887 ATP hydrolysis activity 63/2022 417/18639 0.151079136690647 1.39266272441987 0.00416513094718258 0.0401075441310292 GO:0005201 extracellular matrix structural constituent 30/2022 168/18639 0.178571428571429 1.64608944467995 0.004176540764042 0.0401075441310292 GO:0042277 peptide binding 41/2022 249/18639 0.164658634538153 1.51783990561653 0.00432475717781398 0.0406234235950442 GO:0009378 four-way junction helicase activity 12/2022 48/18639 0.25 2.30452522255193 0.00432713733047371 0.0406234235950442 GO:0043138 3'-5' DNA helicase activity 12/2022 48/18639 0.25 2.30452522255193 0.00432713733047371 0.0406234235950442 GO:0005160 transforming growth factor beta receptor binding 8/2022 26/18639 0.307692307692308 2.83633873544853 0.00491440518608909 0.0428397457636474 GO:0052742 phosphatidylinositol kinase activity 8/2022 26/18639 0.307692307692308 2.83633873544853 0.00491440518608909 0.0428397457636474 GO:0070006 metalloaminopeptidase activity 8/2022 26/18639 0.307692307692308 2.83633873544853 0.00491440518608909 0.0428397457636474 GO:0005324 long-chain fatty acid transmembrane transporter activity 6/2022 16/18639 0.375 3.45678783382789 0.00494882431300746 0.0428397457636474 GO:0140328 floppase activity 6/2022 16/18639 0.375 3.45678783382789 0.00494882431300746 0.0428397457636474 GO:0015026 coreceptor activity 14/2022 61/18639 0.229508196721311 2.11562971250669 0.00495042604924848 0.0428397457636474 GO:0003678 DNA helicase activity 16/2022 74/18639 0.216216216216216 1.99310289518005 0.00517379260168334 0.0428397457636474 GO:0048029 monosaccharide binding 16/2022 74/18639 0.216216216216216 1.99310289518005 0.00517379260168334 0.0428397457636474 GO:0005004 GPI-linked ephrin receptor activity 12/2022 49/18639 0.244897959183673 2.25749409556107 0.0051761854976744 0.0428397457636474 GO:0005008 hepatocyte growth factor receptor activity 12/2022 49/18639 0.244897959183673 2.25749409556107 0.0051761854976744 0.0428397457636474 GO:0005009 insulin receptor activity 12/2022 49/18639 0.244897959183673 2.25749409556107 0.0051761854976744 0.0428397457636474 GO:0005011 macrophage colony-stimulating factor receptor activity 12/2022 49/18639 0.244897959183673 2.25749409556107 0.0051761854976744 0.0428397457636474 GO:0005018 platelet-derived growth factor alpha-receptor activity 12/2022 49/18639 0.244897959183673 2.25749409556107 0.0051761854976744 0.0428397457636474 GO:0005020 stem cell factor receptor activity 12/2022 49/18639 0.244897959183673 2.25749409556107 0.0051761854976744 0.0428397457636474 GO:0008288 boss receptor activity 12/2022 49/18639 0.244897959183673 2.25749409556107 0.0051761854976744 0.0428397457636474 GO:0036332 placental growth factor receptor activity 12/2022 49/18639 0.244897959183673 2.25749409556107 0.0051761854976744 0.0428397457636474 GO:0038062 protein tyrosine kinase collagen receptor activity 12/2022 49/18639 0.244897959183673 2.25749409556107 0.0051761854976744 0.0428397457636474 GO:0060175 brain-derived neurotrophic factor receptor activity 12/2022 49/18639 0.244897959183673 2.25749409556107 0.0051761854976744 0.0428397457636474 GO:0005319 lipid transporter activity 31/2022 178/18639 0.174157303370787 1.60539959323842 0.00532203406576192 0.0437589467629313 GO:0005548 phospholipid transporter activity 15/2022 68/18639 0.220588235294118 2.03340460813405 0.00548670511937134 0.0448199677933062 GO:0004197 cysteine-type endopeptidase activity 18/2022 88/18639 0.204545454545455 1.8855206366334 0.00581201386077573 0.0471710544313282 GO:0005247 voltage-gated chloride channel activity 5/2022 12/18639 0.416666666666667 3.84087537091988 0.00614919485280025 0.0486793414045964 GO:0005007 fibroblast growth factor receptor activity 12/2022 50/18639 0.24 2.21234421364985 0.00615263536035836 0.0486793414045964 GO:0005017 platelet-derived growth factor receptor activity 12/2022 50/18639 0.24 2.21234421364985 0.00615263536035836 0.0486793414045964 GO:0005019 platelet-derived growth factor beta-receptor activity 12/2022 50/18639 0.24 2.21234421364985 0.00615263536035836 0.0486793414045964 GO:0098631 cell adhesion mediator activity 16/2022 76/18639 0.210526315789474 1.9406528189911 0.00677284929126074 0.0532515275525376 GO:0008484 sulfuric ester hydrolase activity 6/2022 17/18639 0.352941176470588 3.25344737301449 0.00695501097745563 0.0540086654915999 GO:0051787 misfolded protein binding 6/2022 17/18639 0.352941176470588 3.25344737301449 0.00695501097745563 0.0540086654915999 GO:0097110 scaffold protein binding 15/2022 70/18639 0.214285714285714 1.97530733361594 0.0072606308966346 0.0559361856627593 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 53/2022 349/18639 0.151862464183381 1.39988351627796 0.00729215774935813 0.0559361856627593 GO:0061775 cohesin loader activity 27/2022 153/18639 0.176470588235294 1.62672368650724 0.00744068885948051 0.0567296156680392 GO:0019902 phosphatase binding 32/2022 190/18639 0.168421052631579 1.55252225519288 0.00775997198776957 0.0588074985579164 GO:0046966 nuclear thyroid hormone receptor binding 8/2022 28/18639 0.285714285714286 2.63374311148792 0.00803557690147854 0.0605314715093413 GO:0017116 single-stranded DNA helicase activity 13/2022 58/18639 0.224137931034483 2.06612606159828 0.00817129269539165 0.0611874179214446 GO:0004713 protein tyrosine kinase activity 25/2022 140/18639 0.178571428571429 1.64608944467995 0.00839889288529072 0.0625195695248268 GO:0015035 protein-disulfide reductase activity 9/2022 34/18639 0.264705882352941 2.44008552976087 0.00864883927590731 0.0640014106417141 GO:0004177 aminopeptidase activity 10/2022 40/18639 0.25 2.30452522255193 0.00885762814270258 0.0646926324756265 GO:0015036 disulfide oxidoreductase activity 10/2022 40/18639 0.25 2.30452522255193 0.00885762814270258 0.0646926324756265 GO:1901681 sulfur compound binding 43/2022 275/18639 0.156363636363636 1.44137577555975 0.0089235968233333 0.0646926324756265 GO:0005158 insulin receptor binding 7/2022 23/18639 0.304347826086957 2.80550896658496 0.00894794757612004 0.0646926324756265 GO:0051011 microtubule minus-end binding 5/2022 13/18639 0.384615384615385 3.54542341931066 0.009109759096336 0.0654861539610896 GO:0070063 RNA polymerase binding 13/2022 59/18639 0.220338983050847 2.03110697580848 0.00946534632158847 0.0676557140486267 GO:0005003 ephrin receptor activity 12/2022 53/18639 0.226415094339623 2.08711718268854 0.0099748296039987 0.0701024337532422 GO:0005005 transmembrane-ephrin receptor activity 12/2022 53/18639 0.226415094339623 2.08711718268854 0.0099748296039987 0.0701024337532422 GO:0038064 collagen receptor activity 12/2022 53/18639 0.226415094339623 2.08711718268854 0.0099748296039987 0.0701024337532422 GO:0042393 histone binding 39/2022 247/18639 0.157894736842105 1.45548961424332 0.0105456287319714 0.0737022274712222 GO:0008201 heparin binding 29/2022 172/18639 0.168604651162791 1.55421468497688 0.0107074245813607 0.0744195586925515 GO:0140658 ATP-dependent chromatin remodeler activity 27/2022 158/18639 0.170886075949367 1.57524508883296 0.0113332019047995 0.0783360878914164 GO:0016500 protein-hormone receptor activity 14/2022 67/18639 0.208955223880597 1.92617033526728 0.011635212175441 0.0799841361568566 GO:0015399 primary active transmembrane transporter activity 28/2022 166/18639 0.168674698795181 1.55486039111937 0.0119279621014996 0.0815509582809049 GO:0016922 nuclear receptor binding 24/2022 137/18639 0.175182481751825 1.61484979098529 0.0121759786035023 0.0827966545038153 GO:0015245 fatty acid transmembrane transporter activity 6/2022 19/18639 0.315789473684211 2.91097922848665 0.0126186939473572 0.0853457902461042 GO:0015926 glucosidase activity 5/2022 14/18639 0.357142857142857 3.2921788893599 0.0129230436911766 0.0869368393770063 GO:0060590 ATPase regulator activity 11/2022 49/18639 0.224489795918367 2.06936958759765 0.0142026414635095 0.0943063516429267 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 17/2022 89/18639 0.191011235955056 1.76076084419698 0.0142434076408236 0.0943063516429267 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 17/2022 89/18639 0.191011235955056 1.76076084419698 0.0142434076408236 0.0943063516429267 GO:0015179 L-amino acid transmembrane transporter activity 13/2022 62/18639 0.209677419354839 1.9328276060113 0.0143226155773153 0.0943342952683907 GO:0008237 metallopeptidase activity 30/2022 184/18639 0.16304347826087 1.50295123209908 0.0150341520926788 0.0985050173572389 GO:0017147 Wnt-protein binding 8/2022 31/18639 0.258064516129032 2.37886474586006 0.0152180446622856 0.0991932652080582 GO:0005085 guanyl-nucleotide exchange factor activity 36/2022 230/18639 0.156521739130435 1.44283318281512 0.0154317730471154 0.100067889140573 GO:0140793 histone H2AXY142 phosphatase activity 17/2022 90/18639 0.188888888888889 1.74119683481701 0.0158383083585456 0.102177394436156 GO:0015605 organophosphate ester transmembrane transporter activity 11/2022 50/18639 0.22 2.0279821958457 0.016473156005424 0.105730766606242 GO:0016303 1-phosphatidylinositol-3-kinase activity 4/2022 10/18639 0.4 3.68724035608309 0.0169377155400868 0.107614374492067 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 4/2022 10/18639 0.4 3.68724035608309 0.0169377155400868 0.107614374492067 GO:0030020 extracellular matrix structural constituent conferring tensile strength 10/2022 44/18639 0.227272727272727 2.09502292959266 0.017411424990755 0.110068204212913 GO:0051117 ATPase binding 16/2022 84/18639 0.19047619047619 1.75582874099195 0.0175117264127335 0.110127916925194 GO:0004467 long-chain fatty acid-CoA ligase activity 5/2022 15/18639 0.333333333333333 3.0727002967359 0.0176834969943474 0.110127916925194 GO:0048531 beta-1,3-galactosyltransferase activity 5/2022 15/18639 0.333333333333333 3.0727002967359 0.0176834969943474 0.110127916925194 GO:0042162 telomeric DNA binding 9/2022 38/18639 0.236842105263158 2.18323442136499 0.0181185143645501 0.112281236801005 GO:0031406 carboxylic acid binding 30/2022 187/18639 0.160427807486631 1.47883971500659 0.0185421954109836 0.114343538367732 GO:0005543 phospholipid binding 69/2022 497/18639 0.138832997987928 1.27977658234272 0.0189613512944838 0.11635795087054 GO:0140104 molecular carrier activity 38/2022 249/18639 0.152610441767068 1.406778449108 0.0191280348518073 0.116811008949386 GO:0140597 protein carrier chaperone 30/2022 188/18639 0.159574468085106 1.47097354630974 0.0198460002643545 0.120609991944725 GO:0044325 transmembrane transporter binding 23/2022 136/18639 0.169117647058824 1.55894353290278 0.0205847864415437 0.123487282053622 GO:0000510 H3-H4 histone complex chaperone activity 25/2022 151/18639 0.165562913907285 1.52617564407412 0.0208351435651416 0.123487282053622 GO:0140584 chromatin extrusion motor activity 25/2022 151/18639 0.165562913907285 1.52617564407412 0.0208351435651416 0.123487282053622 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 25/2022 151/18639 0.165562913907285 1.52617564407412 0.0208351435651416 0.123487282053622 GO:0140849 ATP-dependent H2AZ histone chaperone activity 25/2022 151/18639 0.165562913907285 1.52617564407412 0.0208351435651416 0.123487282053622 GO:0051010 microtubule plus-end binding 6/2022 21/18639 0.285714285714286 2.63374311148792 0.0209084189804622 0.123487282053622 GO:0043177 organic acid binding 30/2022 189/18639 0.158730158730159 1.46319061749329 0.0212211717375125 0.124748757223321 GO:0044389 ubiquitin-like protein ligase binding 47/2022 322/18639 0.145962732919255 1.34549919826013 0.0214241594781708 0.125356244760646 GO:0015616 DNA translocase activity 25/2022 152/18639 0.164473684210526 1.5161350148368 0.0224512537011283 0.130155194267371 GO:0140674 ATP-dependent histone chaperone activity 25/2022 152/18639 0.164473684210526 1.5161350148368 0.0224512537011283 0.130155194267371 GO:0003689 DNA clamp loader activity 26/2022 160/18639 0.1625 1.49794139465875 0.0232623304199053 0.133278944677006 GO:0030276 clathrin binding 10/2022 46/18639 0.217391304347826 2.00393497613211 0.0234626113528459 0.133278944677006 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 5/2022 16/18639 0.3125 2.88065652818991 0.0234719845767748 0.133278944677006 GO:0034450 ubiquitin-ubiquitin ligase activity 5/2022 16/18639 0.3125 2.88065652818991 0.0234719845767748 0.133278944677006 GO:0002162 dystroglycan binding 4/2022 11/18639 0.363636363636364 3.35203668734826 0.0243673746229821 0.133278944677006 GO:0005114 type II transforming growth factor beta receptor binding 4/2022 11/18639 0.363636363636364 3.35203668734826 0.0243673746229821 0.133278944677006 GO:0008432 JUN kinase binding 4/2022 11/18639 0.363636363636364 3.35203668734826 0.0243673746229821 0.133278944677006 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 4/2022 11/18639 0.363636363636364 3.35203668734826 0.0243673746229821 0.133278944677006 GO:0032050 clathrin heavy chain binding 4/2022 11/18639 0.363636363636364 3.35203668734826 0.0243673746229821 0.133278944677006 GO:0032794 GTPase activating protein binding 4/2022 11/18639 0.363636363636364 3.35203668734826 0.0243673746229821 0.133278944677006 GO:0047676 arachidonate-CoA ligase activity 4/2022 11/18639 0.363636363636364 3.35203668734826 0.0243673746229821 0.133278944677006 GO:0050998 nitric-oxide synthase binding 4/2022 11/18639 0.363636363636364 3.35203668734826 0.0243673746229821 0.133278944677006 GO:0097493 structural molecule activity conferring elasticity 4/2022 11/18639 0.363636363636364 3.35203668734826 0.0243673746229821 0.133278944677006 GO:0016860 intramolecular oxidoreductase activity 11/2022 53/18639 0.207547169811321 1.91319075079783 0.0249123213564669 0.134864964540866 GO:0051018 protein kinase A binding 11/2022 53/18639 0.207547169811321 1.91319075079783 0.0249123213564669 0.134864964540866 GO:0050997 quaternary ammonium group binding 9/2022 40/18639 0.225 2.07407270029674 0.0249789640206851 0.134864964540866 GO:0031625 ubiquitin protein ligase binding 44/2022 302/18639 0.145695364238411 1.34303456678523 0.0260485034059305 0.140038535404532 GO:0043495 protein-membrane adaptor activity 10/2022 47/18639 0.212765957446809 1.96129806174632 0.026999120072914 0.14391903835477 GO:0140359 ABC-type transporter activity 10/2022 47/18639 0.212765957446809 1.96129806174632 0.026999120072914 0.14391903835477 GO:0004222 metalloendopeptidase activity 19/2022 110/18639 0.172727272727273 1.59221742649042 0.0272035907379203 0.144397118769214 GO:0004386 helicase activity 25/2022 155/18639 0.161290322580645 1.48679046616253 0.027887589998779 0.147405832850689 GO:0004674 protein serine/threonine kinase activity 60/2022 433/18639 0.138568129330254 1.27733499633363 0.0280591710818743 0.147692205945598 GO:0001727 lipid kinase activity 9/2022 41/18639 0.219512195121951 2.02348556126511 0.02902235394059 0.151494279075777 GO:0016877 ligase activity, forming carbon-sulfur bonds 9/2022 41/18639 0.219512195121951 2.02348556126511 0.02902235394059 0.151494279075777 GO:0008509 monoatomic anion transmembrane transporter activity 24/2022 149/18639 0.161073825503356 1.48479477426165 0.0311563761412054 0.161514389942786 GO:0005539 glycosaminoglycan binding 36/2022 242/18639 0.148760330578512 1.37128773573338 0.0311987255612854 0.161514389942786 GO:0098632 cell-cell adhesion mediator activity 11/2022 55/18639 0.2 1.84362017804154 0.0320497979441345 0.164684710835753 GO:0051861 glycolipid binding 7/2022 29/18639 0.241379310344828 2.22505883556738 0.0320729365300156 0.164684710835753 GO:0001540 amyloid-beta binding 15/2022 83/18639 0.180722891566265 1.6659218476279 0.0323655286166574 0.165511524389248 GO:0015103 inorganic anion transmembrane transporter activity 26/2022 165/18639 0.157575757575758 1.45254923118425 0.0328159550986435 0.165939290949231 GO:0019842 vitamin binding 24/2022 150/18639 0.16 1.47489614243323 0.0334125813096866 0.165939290949231 GO:0005078 MAP-kinase scaffold activity 4/2022 12/18639 0.333333333333333 3.0727002967359 0.0334764645080729 0.165939290949231 GO:0017166 vinculin binding 4/2022 12/18639 0.333333333333333 3.0727002967359 0.0334764645080729 0.165939290949231 GO:0031543 peptidyl-proline dioxygenase activity 4/2022 12/18639 0.333333333333333 3.0727002967359 0.0334764645080729 0.165939290949231 GO:0035497 cAMP response element binding 4/2022 12/18639 0.333333333333333 3.0727002967359 0.0334764645080729 0.165939290949231 GO:0070008 serine-type exopeptidase activity 4/2022 12/18639 0.333333333333333 3.0727002967359 0.0334764645080729 0.165939290949231 GO:0140030 modification-dependent protein binding 27/2022 173/18639 0.15606936416185 1.4386631447145 0.0335044355334695 0.165939290949231 GO:0004725 protein tyrosine phosphatase activity 17/2022 98/18639 0.173469387755102 1.59905831768909 0.0340457980392791 0.16795927032711 GO:0004190 aspartic-type endopeptidase activity 8/2022 36/18639 0.222222222222222 2.0484668644906 0.0359768662419639 0.176792569267151 GO:0005507 copper ion binding 12/2022 63/18639 0.19047619047619 1.75582874099195 0.0364980850411329 0.178655996037919 GO:0019903 protein phosphatase binding 23/2022 144/18639 0.159722222222222 1.47233555885262 0.0373505786211971 0.18212026319948 GO:0001968 fibronectin binding 7/2022 30/18639 0.233333333333333 2.15089020771513 0.0380463468564849 0.184796541874355 GO:0008308 voltage-gated monoatomic anion channel activity 5/2022 18/18639 0.277777777777778 2.56058358061325 0.0383789149707404 0.184983429245944 GO:0070064 proline-rich region binding 5/2022 18/18639 0.277777777777778 2.56058358061325 0.0383789149707404 0.184983429245944 GO:0015295 solute:proton symporter activity 6/2022 24/18639 0.25 2.30452522255193 0.0391885676339079 0.188164954517008 GO:0043394 proteoglycan binding 8/2022 37/18639 0.216216216216216 1.99310289518005 0.0416928908752267 0.198672942125134 GO:0070001 aspartic-type peptidase activity 8/2022 37/18639 0.216216216216216 1.99310289518005 0.0416928908752267 0.198672942125134 GO:0005496 steroid binding 18/2022 108/18639 0.166666666666667 1.53635014836795 0.0423075258389596 0.200841009454382 GO:0015370 solute:sodium symporter activity 14/2022 79/18639 0.177215189873418 1.63358749953048 0.0437539262359381 0.20675878269196 GO:0005338 nucleotide-sugar transmembrane transporter activity 4/2022 13/18639 0.307692307692308 2.83633873544853 0.0443061113577338 0.20675878269196 GO:0043560 insulin receptor substrate binding 4/2022 13/18639 0.307692307692308 2.83633873544853 0.0443061113577338 0.20675878269196 GO:0140333 glycerophospholipid flippase activity 4/2022 13/18639 0.307692307692308 2.83633873544853 0.0443061113577338 0.20675878269196 GO:0016878 acid-thiol ligase activity 7/2022 31/18639 0.225806451612903 2.08150665262755 0.0447046016631265 0.20675878269196 GO:0070325 lipoprotein particle receptor binding 7/2022 31/18639 0.225806451612903 2.08150665262755 0.0447046016631265 0.20675878269196 GO:0072349 modified amino acid transmembrane transporter activity 7/2022 31/18639 0.225806451612903 2.08150665262755 0.0447046016631265 0.20675878269196 GO:0008094 ATP-dependent activity, acting on DNA 31/2022 210/18639 0.147619047619048 1.36076727426876 0.0469398982139464 0.213420091779501 GO:0005537 D-mannose binding 6/2022 25/18639 0.24 2.21234421364985 0.0469931362662336 0.213420091779501 GO:0015645 fatty acid ligase activity 6/2022 25/18639 0.24 2.21234421364985 0.0469931362662336 0.213420091779501 GO:0017056 structural constituent of nuclear pore 6/2022 25/18639 0.24 2.21234421364985 0.0469931362662336 0.213420091779501 GO:0120515 fatty acid-CoA ligase activity 6/2022 25/18639 0.24 2.21234421364985 0.0469931362662336 0.213420091779501 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 5/2022 19/18639 0.263157894736842 2.42581602373887 0.0475789939076629 0.21530350480518 GO:0008234 cysteine-type peptidase activity 28/2022 187/18639 0.149732620320856 1.38025040067281 0.0487864015352878 0.219975961044416 GO:0140713 histone chaperone activity 25/2022 164/18639 0.152439024390244 1.4051983064341 0.0502677506565885 0.225845822592815 GO:0035091 phosphatidylinositol binding 40/2022 284/18639 0.140845070422535 1.29832406904334 0.051186080224771 0.229153341362142 GO:0071813 lipoprotein particle binding 7/2022 32/18639 0.21875 2.01645956973294 0.0520667965947789 0.231448869668664 GO:0071814 protein-lipid complex binding 7/2022 32/18639 0.21875 2.01645956973294 0.0520667965947789 0.231448869668664 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 6/2022 26/18639 0.230769230769231 2.1272540515864 0.0556922491758271 0.244114458059897 GO:0030507 spectrin binding 6/2022 26/18639 0.230769230769231 2.1272540515864 0.0556922491758271 0.244114458059897 GO:0034237 protein kinase A regulatory subunit binding 6/2022 26/18639 0.230769230769231 2.1272540515864 0.0556922491758271 0.244114458059897 GO:0050750 low-density lipoprotein particle receptor binding 6/2022 26/18639 0.230769230769231 2.1272540515864 0.0556922491758271 0.244114458059897 GO:0005545 1-phosphatidylinositol binding 4/2022 14/18639 0.285714285714286 2.63374311148792 0.0568593384243568 0.245804287758903 GO:0032454 histone H3K9 demethylase activity 4/2022 14/18639 0.285714285714286 2.63374311148792 0.0568593384243568 0.245804287758903 GO:0042043 neurexin family protein binding 4/2022 14/18639 0.285714285714286 2.63374311148792 0.0568593384243568 0.245804287758903 GO:1901474 azole transmembrane transporter activity 4/2022 14/18639 0.285714285714286 2.63374311148792 0.0568593384243568 0.245804287758903 GO:0003725 double-stranded RNA binding 13/2022 75/18639 0.173333333333333 1.59780415430267 0.0589557492139742 0.253994289421848 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 7/2022 33/18639 0.212121212121212 1.95535473428649 0.0601467028868508 0.257639181746303 GO:0033218 amide binding 35/2022 247/18639 0.1417004048583 1.30620862816709 0.0602113826974666 0.257639181746303 GO:0032934 sterol binding 12/2022 68/18639 0.176470588235294 1.62672368650724 0.0605576385005979 0.258242404182211 GO:0005516 calmodulin binding 30/2022 207/18639 0.144927536231884 1.33595665075474 0.0609640659550054 0.259097280308773 GO:0071949 FAD binding 8/2022 40/18639 0.2 1.84362017804154 0.0623190877149807 0.263964351331467 GO:0140463 chromatin-protein adaptor activity 10/2022 54/18639 0.185185185185185 1.70705572040884 0.0627717296030524 0.26498938201557 GO:0042578 phosphoric ester hydrolase activity 49/2022 363/18639 0.134986225895317 1.2443166490914 0.0632577561695784 0.26614801759642 GO:0016791 phosphatase activity 38/2022 273/18639 0.139194139194139 1.28310561841719 0.0647534944654256 0.271532986791685 GO:0005044 scavenger receptor activity 6/2022 27/18639 0.222222222222222 2.0484668644906 0.0652960299459843 0.271994720768372 GO:0016405 CoA-ligase activity 6/2022 27/18639 0.222222222222222 2.0484668644906 0.0652960299459843 0.271994720768372 GO:0015020 glucuronosyltransferase activity 7/2022 34/18639 0.205882352941176 1.89784430092512 0.0689526494644749 0.285783432817907 GO:0009931 calcium-dependent protein serine/threonine kinase activity 5/2022 21/18639 0.238095238095238 2.19478592623993 0.0695518441607815 0.285783432817907 GO:0008374 O-acyltransferase activity 10/2022 55/18639 0.181818181818182 1.67601834367413 0.0695988255272565 0.285783432817907 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 8/2022 41/18639 0.195121951219512 1.79865383223565 0.070391023175439 0.285783432817907 GO:0015175 neutral L-amino acid transmembrane transporter activity 8/2022 41/18639 0.195121951219512 1.79865383223565 0.070391023175439 0.285783432817907 GO:0000774 adenyl-nucleotide exchange factor activity 4/2022 15/18639 0.266666666666667 2.45816023738872 0.07110509894436 0.285783432817907 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 4/2022 15/18639 0.266666666666667 2.45816023738872 0.07110509894436 0.285783432817907 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 4/2022 15/18639 0.266666666666667 2.45816023738872 0.07110509894436 0.285783432817907 GO:0005402 carbohydrate:monoatomic cation symporter activity 4/2022 15/18639 0.266666666666667 2.45816023738872 0.07110509894436 0.285783432817907 GO:0061578 K63-linked deubiquitinase activity 4/2022 15/18639 0.266666666666667 2.45816023738872 0.07110509894436 0.285783432817907 GO:0120283 protein serine/threonine kinase binding 4/2022 15/18639 0.266666666666667 2.45816023738872 0.07110509894436 0.285783432817907 GO:1901682 sulfur compound transmembrane transporter activity 11/2022 63/18639 0.174603174603175 1.60950967924262 0.0748837071460706 0.300011794871837 GO:0051019 mitogen-activated protein kinase binding 6/2022 28/18639 0.214285714285714 1.97530733361594 0.0758058118385592 0.301783896496543 GO:0097718 disordered domain specific binding 6/2022 28/18639 0.214285714285714 1.97530733361594 0.0758058118385592 0.301783896496543 GO:0005343 organic acid:sodium symporter activity 7/2022 35/18639 0.2 1.84362017804154 0.0784874946032136 0.31147403221086 GO:0140097 catalytic activity, acting on DNA 45/2022 336/18639 0.133928571428571 1.23456708350996 0.0800028166029472 0.316489129831785 GO:0008093 cytoskeletal anchor activity 5/2022 22/18639 0.227272727272727 2.09502292959266 0.0823087824402845 0.322785743648414 GO:0019207 kinase regulator activity 39/2022 287/18639 0.13588850174216 1.2526339188784 0.0825039870477685 0.322785743648414 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 26/2022 181/18639 0.143646408839779 1.32414708920111 0.0832527386051616 0.322785743648414 GO:0005337 nucleoside transmembrane transporter activity 3/2022 10/18639 0.3 2.76543026706231 0.0854900280984102 0.322785743648414 GO:0005345 purine nucleobase transmembrane transporter activity 3/2022 10/18639 0.3 2.76543026706231 0.0854900280984102 0.322785743648414 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 3/2022 10/18639 0.3 2.76543026706231 0.0854900280984102 0.322785743648414 GO:0015643 toxic substance binding 3/2022 10/18639 0.3 2.76543026706231 0.0854900280984102 0.322785743648414 GO:0015658 branched-chain amino acid transmembrane transporter activity 3/2022 10/18639 0.3 2.76543026706231 0.0854900280984102 0.322785743648414 GO:0031957 very long-chain fatty acid-CoA ligase activity 3/2022 10/18639 0.3 2.76543026706231 0.0854900280984102 0.322785743648414 GO:0043121 neurotrophin binding 3/2022 10/18639 0.3 2.76543026706231 0.0854900280984102 0.322785743648414 GO:0043295 glutathione binding 3/2022 10/18639 0.3 2.76543026706231 0.0854900280984102 0.322785743648414 GO:0045322 unmethylated CpG binding 3/2022 10/18639 0.3 2.76543026706231 0.0854900280984102 0.322785743648414 GO:0051864 histone H3K36 demethylase activity 3/2022 10/18639 0.3 2.76543026706231 0.0854900280984102 0.322785743648414 GO:0070097 delta-catenin binding 3/2022 10/18639 0.3 2.76543026706231 0.0854900280984102 0.322785743648414 GO:1905394 retromer complex binding 3/2022 10/18639 0.3 2.76543026706231 0.0854900280984102 0.322785743648414 GO:0022853 active monoatomic ion transmembrane transporter activity 18/2022 118/18639 0.152542372881356 1.40615098325202 0.0858572800127581 0.322785743648414 GO:0017171 serine hydrolase activity 28/2022 198/18639 0.141414141414141 1.30356982285766 0.0867823214920472 0.322785743648414 GO:0005159 insulin-like growth factor receptor binding 4/2022 16/18639 0.25 2.30452522255193 0.0869828037335551 0.322785743648414 GO:0015562 efflux transmembrane transporter activity 4/2022 16/18639 0.25 2.30452522255193 0.0869828037335551 0.322785743648414 GO:0016722 oxidoreductase activity, acting on metal ions 4/2022 16/18639 0.25 2.30452522255193 0.0869828037335551 0.322785743648414 GO:0022858 alanine transmembrane transporter activity 4/2022 16/18639 0.25 2.30452522255193 0.0869828037335551 0.322785743648414 GO:0016409 palmitoyltransferase activity 7/2022 36/18639 0.194444444444444 1.79240850642928 0.0887486807593774 0.328370118809696 GO:0004721 phosphoprotein phosphatase activity 25/2022 175/18639 0.142857142857143 1.31687155574396 0.0923961195099221 0.340863103646575 GO:0017134 fibroblast growth factor binding 5/2022 23/18639 0.217391304347826 2.00393497613211 0.0962113501641525 0.353900229551181 GO:0031490 chromatin DNA binding 19/2022 128/18639 0.1484375 1.36831185089021 0.0976933908295778 0.357223149055515 GO:0003779 actin binding 57/2022 443/18639 0.128668171557562 1.18607618677616 0.0979194483259656 0.357223149055515 GO:0140789 histone phosphatase activity 20/2022 136/18639 0.147058823529412 1.35560307208937 0.0979959988562645 0.357223149055515 GO:0016790 thiolester hydrolase activity 8/2022 44/18639 0.181818181818182 1.67601834367413 0.0982505640486551 0.357223149055515 GO:0031210 phosphatidylcholine binding 6/2022 30/18639 0.2 1.84362017804154 0.0995063982933855 0.358679223647791 GO:0031624 ubiquitin conjugating enzyme binding 6/2022 30/18639 0.2 1.84362017804154 0.0995063982933855 0.358679223647791 GO:0035925 mRNA 3'-UTR AU-rich region binding 6/2022 30/18639 0.2 1.84362017804154 0.0995063982933855 0.358679223647791 GO:0015108 chloride transmembrane transporter activity 18/2022 121/18639 0.148760330578512 1.37128773573338 0.103152935945696 0.368597478715766 GO:0035591 signaling adaptor activity 19/2022 129/18639 0.147286821705426 1.35770478227866 0.103500464541231 0.368597478715766 GO:0008429 phosphatidylethanolamine binding 4/2022 17/18639 0.235294117647059 2.16896491534299 0.104407033525472 0.368597478715766 GO:0016805 dipeptidase activity 4/2022 17/18639 0.235294117647059 2.16896491534299 0.104407033525472 0.368597478715766 GO:0030169 low-density lipoprotein particle binding 4/2022 17/18639 0.235294117647059 2.16896491534299 0.104407033525472 0.368597478715766 GO:0032183 SUMO binding 4/2022 17/18639 0.235294117647059 2.16896491534299 0.104407033525472 0.368597478715766 GO:0005080 protein kinase C binding 9/2022 52/18639 0.173076923076923 1.5954405386898 0.105294756823718 0.368597478715766 GO:0008236 serine-type peptidase activity 27/2022 194/18639 0.139175257731959 1.28293156719386 0.105414160699916 0.368597478715766 GO:0005225 volume-sensitive anion channel activity 3/2022 11/18639 0.272727272727273 2.5140275155112 0.108411023151696 0.368597478715766 GO:0008046 axon guidance receptor activity 3/2022 11/18639 0.272727272727273 2.5140275155112 0.108411023151696 0.368597478715766 GO:0008172 S-methyltransferase activity 3/2022 11/18639 0.272727272727273 2.5140275155112 0.108411023151696 0.368597478715766 GO:0008271 secondary active sulfate transmembrane transporter activity 3/2022 11/18639 0.272727272727273 2.5140275155112 0.108411023151696 0.368597478715766 GO:0015173 aromatic amino acid transmembrane transporter activity 3/2022 11/18639 0.272727272727273 2.5140275155112 0.108411023151696 0.368597478715766 GO:0015205 nucleobase transmembrane transporter activity 3/2022 11/18639 0.272727272727273 2.5140275155112 0.108411023151696 0.368597478715766 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 3/2022 11/18639 0.272727272727273 2.5140275155112 0.108411023151696 0.368597478715766 GO:0019215 intermediate filament binding 3/2022 11/18639 0.272727272727273 2.5140275155112 0.108411023151696 0.368597478715766 GO:0034056 estrogen response element binding 3/2022 11/18639 0.272727272727273 2.5140275155112 0.108411023151696 0.368597478715766 GO:0034713 type I transforming growth factor beta receptor binding 3/2022 11/18639 0.272727272727273 2.5140275155112 0.108411023151696 0.368597478715766 GO:0042608 T cell receptor binding 3/2022 11/18639 0.272727272727273 2.5140275155112 0.108411023151696 0.368597478715766 GO:0045294 alpha-catenin binding 3/2022 11/18639 0.272727272727273 2.5140275155112 0.108411023151696 0.368597478715766 GO:1900750 oligopeptide binding 3/2022 11/18639 0.272727272727273 2.5140275155112 0.108411023151696 0.368597478715766 GO:0044183 protein folding chaperone 12/2022 75/18639 0.16 1.47489614243323 0.108955308137775 0.368837711715196 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 10/2022 60/18639 0.166666666666667 1.53635014836795 0.110541138913394 0.368837711715196 GO:0035035 histone acetyltransferase binding 5/2022 24/18639 0.208333333333333 1.92043768545994 0.111217345566848 0.368837711715196 GO:0042625 ATPase-coupled ion transmembrane transporter activity 5/2022 24/18639 0.208333333333333 1.92043768545994 0.111217345566848 0.368837711715196 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 5/2022 24/18639 0.208333333333333 1.92043768545994 0.111217345566848 0.368837711715196 GO:0046961 proton-transporting ATPase activity, rotational mechanism 5/2022 24/18639 0.208333333333333 1.92043768545994 0.111217345566848 0.368837711715196 GO:0050699 WW domain binding 5/2022 24/18639 0.208333333333333 1.92043768545994 0.111217345566848 0.368837711715196 GO:0070840 dynein complex binding 5/2022 24/18639 0.208333333333333 1.92043768545994 0.111217345566848 0.368837711715196 GO:0005109 frizzled binding 7/2022 38/18639 0.184210526315789 1.69807121661721 0.111413617211268 0.368837711715196 GO:0043531 ADP binding 7/2022 38/18639 0.184210526315789 1.69807121661721 0.111413617211268 0.368837711715196 GO:0030145 manganese ion binding 11/2022 68/18639 0.161764705882353 1.49116337929831 0.114441928535819 0.377868624929293 GO:0001221 transcription coregulator binding 17/2022 115/18639 0.147826086956522 1.36267578376984 0.115628635579626 0.378804228018672 GO:0035401 histone H3Y41 kinase activity 17/2022 115/18639 0.147826086956522 1.36267578376984 0.115628635579626 0.378804228018672 GO:0140801 histone H2AXY142 kinase activity 17/2022 115/18639 0.147826086956522 1.36267578376984 0.115628635579626 0.378804228018672 GO:0046873 metal ion transmembrane transporter activity 57/2022 450/18639 0.126666666666667 1.16762611275964 0.120480263897168 0.393673173980877 GO:0000900 mRNA regulatory element binding translation repressor activity 4/2022 18/18639 0.222222222222222 2.0484668644906 0.123272210255396 0.400714316540796 GO:1990381 ubiquitin-specific protease binding 4/2022 18/18639 0.222222222222222 2.0484668644906 0.123272210255396 0.400714316540796 GO:0015485 cholesterol binding 9/2022 54/18639 0.166666666666667 1.53635014836795 0.125802816414444 0.405341606450984 GO:0050661 NADP binding 9/2022 54/18639 0.166666666666667 1.53635014836795 0.125802816414444 0.405341606450984 GO:0022884 macromolecule transmembrane transporter activity 6/2022 32/18639 0.1875 1.72839391691395 0.126641606305387 0.405341606450984 GO:0042910 xenobiotic transmembrane transporter activity 6/2022 32/18639 0.1875 1.72839391691395 0.126641606305387 0.405341606450984 GO:0140142 nucleocytoplasmic carrier activity 6/2022 32/18639 0.1875 1.72839391691395 0.126641606305387 0.405341606450984 GO:0004709 MAP kinase kinase kinase activity 5/2022 25/18639 0.2 1.84362017804154 0.127273397892002 0.405341606450984 GO:0008139 nuclear localization sequence binding 5/2022 25/18639 0.2 1.84362017804154 0.127273397892002 0.405341606450984 GO:0047617 fatty acyl-CoA hydrolase activity 5/2022 25/18639 0.2 1.84362017804154 0.127273397892002 0.405341606450984 GO:1990782 protein tyrosine kinase binding 17/2022 117/18639 0.145299145299145 1.33938218062847 0.129667661066588 0.411924034398403 GO:0008028 monocarboxylic acid transmembrane transporter activity 11/2022 70/18639 0.157142857142857 1.44855871131836 0.133057958494689 0.416386167202794 GO:0000340 RNA 7-methylguanosine cap binding 3/2022 12/18639 0.25 2.30452522255193 0.133389209366237 0.416386167202794 GO:0004300 enoyl-CoA hydratase activity 3/2022 12/18639 0.25 2.30452522255193 0.133389209366237 0.416386167202794 GO:0005049 nuclear export signal receptor activity 3/2022 12/18639 0.25 2.30452522255193 0.133389209366237 0.416386167202794 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 3/2022 12/18639 0.25 2.30452522255193 0.133389209366237 0.416386167202794 GO:0035014 phosphatidylinositol 3-kinase regulator activity 3/2022 12/18639 0.25 2.30452522255193 0.133389209366237 0.416386167202794 GO:0035251 UDP-glucosyltransferase activity 3/2022 12/18639 0.25 2.30452522255193 0.133389209366237 0.416386167202794 GO:0015144 carbohydrate transmembrane transporter activity 7/2022 40/18639 0.175 1.61316765578635 0.136825255272829 0.426054879042622 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 35/2022 268/18639 0.130597014925373 1.20385645954205 0.142058710033559 0.438527035994439 GO:0005346 purine ribonucleotide transmembrane transporter activity 4/2022 19/18639 0.210526315789474 1.9406528189911 0.143457067948125 0.438527035994439 GO:0008381 mechanosensitive monoatomic ion channel activity 4/2022 19/18639 0.210526315789474 1.9406528189911 0.143457067948125 0.438527035994439 GO:0008574 plus-end-directed microtubule motor activity 4/2022 19/18639 0.210526315789474 1.9406528189911 0.143457067948125 0.438527035994439 GO:0030506 ankyrin binding 4/2022 19/18639 0.210526315789474 1.9406528189911 0.143457067948125 0.438527035994439 GO:0042577 lipid phosphatase activity 4/2022 19/18639 0.210526315789474 1.9406528189911 0.143457067948125 0.438527035994439 GO:1990380 K48-linked deubiquitinase activity 4/2022 19/18639 0.210526315789474 1.9406528189911 0.143457067948125 0.438527035994439 GO:0005112 Notch binding 5/2022 26/18639 0.192307692307692 1.77271170965533 0.144316528538711 0.438527035994439 GO:0015145 monosaccharide transmembrane transporter activity 5/2022 26/18639 0.192307692307692 1.77271170965533 0.144316528538711 0.438527035994439 GO:0016289 acyl-CoA hydrolase activity 5/2022 26/18639 0.192307692307692 1.77271170965533 0.144316528538711 0.438527035994439 GO:0005253 monoatomic anion channel activity 15/2022 103/18639 0.145631067961165 1.34244187721472 0.145687223209725 0.440748853142174 GO:0004867 serine-type endopeptidase inhibitor activity 14/2022 95/18639 0.147368421052632 1.35845697329377 0.145748428384057 0.440748853142174 GO:0141003 histone H2AX kinase activity 45/2022 354/18639 0.127118644067797 1.17179248604335 0.146708639742547 0.442588654187349 GO:0001217 DNA-binding transcription repressor activity 36/2022 278/18639 0.129496402877698 1.1937109066456 0.149833095877669 0.450933097162936 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 60/2022 484/18639 0.12396694214876 1.14273977977782 0.150303980986868 0.45127066367895 GO:0032182 ubiquitin-like protein binding 17/2022 120/18639 0.141666666666667 1.30589762611276 0.152486360283949 0.456732955326687 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 30/2022 229/18639 0.131004366812227 1.20761147033289 0.159352095687565 0.472539270570067 GO:0005542 folic acid binding 3/2022 13/18639 0.230769230769231 2.1272540515864 0.160114138768788 0.472539270570067 GO:0008417 fucosyltransferase activity 3/2022 13/18639 0.230769230769231 2.1272540515864 0.160114138768788 0.472539270570067 GO:0035673 oligopeptide transmembrane transporter activity 3/2022 13/18639 0.230769230769231 2.1272540515864 0.160114138768788 0.472539270570067 GO:0046975 histone H3K36 methyltransferase activity 3/2022 13/18639 0.230769230769231 2.1272540515864 0.160114138768788 0.472539270570067 GO:0061459 L-arginine transmembrane transporter activity 3/2022 13/18639 0.230769230769231 2.1272540515864 0.160114138768788 0.472539270570067 GO:0140996 histone H3 kinase activity 45/2022 357/18639 0.126050420168067 1.16194549036232 0.160392900265038 0.472539270570067 GO:0001671 ATPase activator activity 5/2022 27/18639 0.185185185185185 1.70705572040884 0.16227573276433 0.475537347682837 GO:0008320 protein transmembrane transporter activity 5/2022 27/18639 0.185185185185185 1.70705572040884 0.16227573276433 0.475537347682837 GO:0160215 deacylase activity 10/2022 65/18639 0.153846153846154 1.41816936772426 0.162544562403514 0.475537347682837 GO:0035198 miRNA binding 7/2022 42/18639 0.166666666666667 1.53635014836795 0.1647893211132 0.47777569208395 GO:0043175 RNA polymerase core enzyme binding 7/2022 42/18639 0.166666666666667 1.53635014836795 0.1647893211132 0.47777569208395 GO:0000339 RNA cap binding 4/2022 20/18639 0.2 1.84362017804154 0.16482881586998 0.47777569208395 GO:0005326 neurotransmitter transmembrane transporter activity 4/2022 20/18639 0.2 1.84362017804154 0.16482881586998 0.47777569208395 GO:0035173 histone kinase activity 45/2022 360/18639 0.125 1.15226261127596 0.17479680936492 0.504378743935366 GO:0035064 methylated histone binding 11/2022 74/18639 0.148648648648649 1.37025824043628 0.174808531284435 0.504378743935366 GO:0031072 heat shock protein binding 18/2022 131/18639 0.137404580152672 1.26660928262396 0.175230003261477 0.504437858359127 GO:0019209 kinase activator activity 20/2022 148/18639 0.135135135135135 1.24568930948753 0.178566668928101 0.512179015296762 GO:0001216 DNA-binding transcription activator activity 60/2022 491/18639 0.122199592668024 1.12644817395614 0.178733376562225 0.512179015296762 GO:0017124 SH3 domain binding 16/2022 115/18639 0.139130434782609 1.28251838472455 0.179351680627252 0.512473500467028 GO:0004712 protein serine/threonine/tyrosine kinase activity 7/2022 43/18639 0.162790697674419 1.50062107515009 0.179650885298855 0.512473500467028 GO:0019789 SUMO transferase activity 5/2022 28/18639 0.178571428571429 1.64608944467995 0.181073541661237 0.514199809051548 GO:0051119 sugar transmembrane transporter activity 5/2022 28/18639 0.178571428571429 1.64608944467995 0.181073541661237 0.514199809051548 GO:0016597 amino acid binding 8/2022 51/18639 0.156862745098039 1.44597661022866 0.183407907857824 0.518487973225039 GO:0030544 Hsp70 protein binding 8/2022 51/18639 0.156862745098039 1.44597661022866 0.183407907857824 0.518487973225039 GO:0005254 chloride channel activity 12/2022 83/18639 0.144578313253012 1.33273747810232 0.185461465631513 0.520548065690783 GO:0015174 basic amino acid transmembrane transporter activity 4/2022 21/18639 0.19047619047619 1.75582874099195 0.187246926860379 0.520548065690783 GO:0036122 BMP binding 4/2022 21/18639 0.19047619047619 1.75582874099195 0.187246926860379 0.520548065690783 GO:0004065 arylsulfatase activity 3/2022 14/18639 0.214285714285714 1.97530733361594 0.188274538862723 0.520548065690783 GO:0031404 chloride ion binding 3/2022 14/18639 0.214285714285714 1.97530733361594 0.188274538862723 0.520548065690783 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 3/2022 14/18639 0.214285714285714 1.97530733361594 0.188274538862723 0.520548065690783 GO:0044548 S100 protein binding 3/2022 14/18639 0.214285714285714 1.97530733361594 0.188274538862723 0.520548065690783 GO:0046030 inositol trisphosphate phosphatase activity 3/2022 14/18639 0.214285714285714 1.97530733361594 0.188274538862723 0.520548065690783 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 3/2022 14/18639 0.214285714285714 1.97530733361594 0.188274538862723 0.520548065690783 GO:0061665 SUMO ligase activity 3/2022 14/18639 0.214285714285714 1.97530733361594 0.188274538862723 0.520548065690783 GO:0000993 RNA polymerase II complex binding 6/2022 36/18639 0.166666666666667 1.53635014836795 0.190065678353689 0.5232004887723 GO:0044390 ubiquitin-like protein conjugating enzyme binding 6/2022 36/18639 0.166666666666667 1.53635014836795 0.190065678353689 0.5232004887723 GO:0004843 cysteine-type deubiquitinase activity 15/2022 108/18639 0.138888888888889 1.28029179030663 0.190723865701608 0.523865989197866 GO:0001046 core promoter sequence-specific DNA binding 7/2022 44/18639 0.159090909090909 1.46651605071486 0.19505094607592 0.534584074430299 GO:0140034 methylation-dependent protein binding 11/2022 76/18639 0.144736842105263 1.33419881305638 0.197772142939356 0.540863816995021 GO:1990841 promoter-specific chromatin binding 10/2022 68/18639 0.147058823529412 1.35560307208937 0.198554171224651 0.541824614751869 GO:0003785 actin monomer binding 5/2022 29/18639 0.172413793103448 1.58932773969099 0.200627532006077 0.545117570763811 GO:0016417 S-acyltransferase activity 5/2022 29/18639 0.172413793103448 1.58932773969099 0.200627532006077 0.545117570763811 GO:1901981 phosphatidylinositol phosphate binding 24/2022 185/18639 0.12972972972973 1.19586173710803 0.204456852941415 0.554324829742027 GO:0023023 MHC protein complex binding 6/2022 37/18639 0.162162162162162 1.49482717138503 0.20755031963524 0.56150172494867 GO:0015377 chloride:monoatomic cation symporter activity 4/2022 22/18639 0.181818181818182 1.67601834367413 0.210566514509289 0.567041655891572 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/2022 22/18639 0.181818181818182 1.67601834367413 0.210566514509289 0.567041655891572 GO:0042605 peptide antigen binding 7/2022 45/18639 0.155555555555556 1.43392680514342 0.210950313956483 0.567041655891572 GO:0015171 amino acid transmembrane transporter activity 14/2022 102/18639 0.137254901960784 1.26522953395008 0.213499396396012 0.572670022742395 GO:0010181 FMN binding 3/2022 15/18639 0.2 1.84362017804154 0.217566898842315 0.577424385535088 GO:0015116 sulfate transmembrane transporter activity 3/2022 15/18639 0.2 1.84362017804154 0.217566898842315 0.577424385535088 GO:0016846 carbon-sulfur lyase activity 3/2022 15/18639 0.2 1.84362017804154 0.217566898842315 0.577424385535088 GO:0042809 nuclear vitamin D receptor binding 3/2022 15/18639 0.2 1.84362017804154 0.217566898842315 0.577424385535088 GO:0140776 protein-containing complex destabilizing activity 3/2022 15/18639 0.2 1.84362017804154 0.217566898842315 0.577424385535088 GO:0050660 flavin adenine dinucleotide binding 12/2022 86/18639 0.13953488372093 1.28624663584294 0.21934408107389 0.580915482086219 GO:0015215 nucleotide transmembrane transporter activity 5/2022 30/18639 0.166666666666667 1.53635014836795 0.220851758748615 0.582456001060288 GO:0098918 structural constituent of synapse 5/2022 30/18639 0.166666666666667 1.53635014836795 0.220851758748615 0.582456001060288 GO:0106310 protein serine kinase activity 44/2022 361/18639 0.121883656509695 1.12353584257379 0.226291717048185 0.595554351561959 GO:0003925 G protein activity 8/2022 54/18639 0.148148148148148 1.36564457632707 0.22727685181604 0.596898287232939 GO:0000295 adenine nucleotide transmembrane transporter activity 4/2022 23/18639 0.173913043478261 1.60314798090569 0.23464128595037 0.611136102951482 GO:0004602 glutathione peroxidase activity 4/2022 23/18639 0.173913043478261 1.60314798090569 0.23464128595037 0.611136102951482 GO:0005283 amino acid:sodium symporter activity 4/2022 23/18639 0.173913043478261 1.60314798090569 0.23464128595037 0.611136102951482 GO:0016849 phosphorus-oxygen lyase activity 4/2022 23/18639 0.173913043478261 1.60314798090569 0.23464128595037 0.611136102951482 GO:0005310 dicarboxylic acid transmembrane transporter activity 5/2022 31/18639 0.161290322580645 1.48679046616253 0.241658091299378 0.624587768544503 GO:0005452 solute:inorganic anion antiporter activity 5/2022 31/18639 0.161290322580645 1.48679046616253 0.241658091299378 0.624587768544503 GO:0016411 acylglycerol O-acyltransferase activity 5/2022 31/18639 0.161290322580645 1.48679046616253 0.241658091299378 0.624587768544503 GO:0015081 sodium ion transmembrane transporter activity 21/2022 164/18639 0.128048780487805 1.18036657740465 0.24179192629664 0.624587768544503 GO:0140938 histone H3 methyltransferase activity 7/2022 47/18639 0.148936170212766 1.37290864322243 0.244080020719472 0.627927464495129 GO:0016776 phosphotransferase activity, phosphate group as acceptor 6/2022 39/18639 0.153846153846154 1.41816936772426 0.244083092319649 0.627927464495129 GO:0004708 MAP kinase kinase activity 3/2022 16/18639 0.1875 1.72839391691395 0.247701690021259 0.632066381433557 GO:0005521 lamin binding 3/2022 16/18639 0.1875 1.72839391691395 0.247701690021259 0.632066381433557 GO:0070411 I-SMAD binding 3/2022 16/18639 0.1875 1.72839391691395 0.247701690021259 0.632066381433557 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 3/2022 16/18639 0.1875 1.72839391691395 0.247701690021259 0.632066381433557 GO:0051015 actin filament binding 26/2022 209/18639 0.124401913875598 1.14674939304019 0.258007275505372 0.655084741216988 GO:0170055 lipid transmembrane transporter activity 8/2022 56/18639 0.142857142857143 1.31687155574396 0.258411252409015 0.655084741216988 GO:0015149 hexose transmembrane transporter activity 4/2022 24/18639 0.166666666666667 1.53635014836795 0.259326074027075 0.655084741216988 GO:0030552 cAMP binding 4/2022 24/18639 0.166666666666667 1.53635014836795 0.259326074027075 0.655084741216988 GO:0055056 D-glucose transmembrane transporter activity 4/2022 24/18639 0.166666666666667 1.53635014836795 0.259326074027075 0.655084741216988 GO:0032266 phosphatidylinositol-3-phosphate binding 7/2022 48/18639 0.145833333333333 1.34430637982196 0.261223051471659 0.65711571984905 GO:0015106 bicarbonate transmembrane transporter activity 5/2022 32/18639 0.15625 1.44032826409496 0.262957440372339 0.65711571984905 GO:0070717 poly-purine tract binding 5/2022 32/18639 0.15625 1.44032826409496 0.262957440372339 0.65711571984905 GO:0030331 nuclear estrogen receptor binding 6/2022 40/18639 0.15 1.38271513353116 0.263010945916146 0.65711571984905 GO:0140662 ATP-dependent protein folding chaperone 6/2022 40/18639 0.15 1.38271513353116 0.263010945916146 0.65711571984905 GO:0101005 deubiquitinase activity 15/2022 115/18639 0.130434782608696 1.20236098567927 0.263264167570685 0.65711571984905 GO:0019210 kinase inhibitor activity 12/2022 90/18639 0.133333333333333 1.22908011869436 0.268080112032398 0.667811447399517 GO:0019888 protein phosphatase regulator activity 14/2022 107/18639 0.130841121495327 1.20610665853185 0.268905623608597 0.668544020750228 GO:0016504 peptidase activator activity 8/2022 57/18639 0.140350877192982 1.29376854599407 0.274444090040159 0.680967781598658 GO:0019887 protein kinase regulator activity 31/2022 255/18639 0.12156862745098 1.12063187292721 0.276804283293518 0.684753942410243 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 3/2022 17/18639 0.176470588235294 1.62672368650724 0.278407687841785 0.684753942410243 GO:0015278 intracellularly gated calcium channel activity 3/2022 17/18639 0.176470588235294 1.62672368650724 0.278407687841785 0.684753942410243 GO:0032977 membrane insertase activity 3/2022 17/18639 0.176470588235294 1.62672368650724 0.278407687841785 0.684753942410243 GO:0001222 transcription corepressor binding 7/2022 49/18639 0.142857142857143 1.31687155574396 0.278691588643914 0.684753942410243 GO:0072341 modified amino acid binding 12/2022 91/18639 0.131868131868132 1.21557374376365 0.280798493909206 0.688585780385539 GO:0003707 nuclear steroid receptor activity 4/2022 25/18639 0.16 1.47489614243323 0.284478964719469 0.689546315254513 GO:0015296 monoatomic anion:monoatomic cation symporter activity 4/2022 25/18639 0.16 1.47489614243323 0.284478964719469 0.689546315254513 GO:0019706 protein-cysteine S-palmitoyltransferase activity 4/2022 25/18639 0.16 1.47489614243323 0.284478964719469 0.689546315254513 GO:0019707 protein-cysteine S-acyltransferase activity 4/2022 25/18639 0.16 1.47489614243323 0.284478964719469 0.689546315254513 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 4/2022 25/18639 0.16 1.47489614243323 0.284478964719469 0.689546315254513 GO:0120020 cholesterol transfer activity 4/2022 25/18639 0.16 1.47489614243323 0.284478964719469 0.689546315254513 GO:0019208 phosphatase regulator activity 15/2022 117/18639 0.128205128205128 1.18180780643689 0.285644116554837 0.690327613510833 GO:0043130 ubiquitin binding 13/2022 100/18639 0.13 1.198353115727 0.286982513250977 0.690327613510833 GO:0061980 regulatory RNA binding 8/2022 58/18639 0.137931034482759 1.27146219175279 0.29074053506303 0.690327613510833 GO:0052689 carboxylic ester hydrolase activity 12/2022 92/18639 0.130434782608696 1.20236098567927 0.29369788370363 0.690327613510833 GO:0000182 rDNA binding 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0004382 GDP phosphatase activity 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0004445 inositol-polyphosphate 5-phosphatase activity 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0005381 iron ion transmembrane transporter activity 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0005522 profilin binding 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0008190 eukaryotic initiation factor 4E binding 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0015203 polyamine transmembrane transporter activity 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0015279 store-operated calcium channel activity 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0019911 structural constituent of myelin sheath 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0031419 cobalamin binding 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0031956 medium-chain fatty acid-CoA ligase activity 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0043208 glycosphingolipid binding 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0070513 death domain binding 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0098505 G-rich strand telomeric DNA binding 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0099122 RNA polymerase II C-terminal domain binding 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0140999 histone H3K4 trimethyltransferase activity 2/2022 10/18639 0.2 1.84362017804154 0.296873798815072 0.690327613510833 GO:0004860 protein kinase inhibitor activity 11/2022 84/18639 0.130952380952381 1.20713225943196 0.300722561250908 0.697987051759487 GO:0052866 phosphatidylinositol phosphate phosphatase activity 5/2022 34/18639 0.147058823529412 1.35560307208937 0.306680569049836 0.70258289979014 GO:0051219 phosphoprotein binding 12/2022 93/18639 0.129032258064516 1.18943237293003 0.306761247736944 0.70258289979014 GO:0004706 JUN kinase kinase kinase activity 3/2022 18/18639 0.166666666666667 1.53635014836795 0.309434783359062 0.70258289979014 GO:0008525 phosphatidylcholine transporter activity 3/2022 18/18639 0.166666666666667 1.53635014836795 0.309434783359062 0.70258289979014 GO:0015172 acidic amino acid transmembrane transporter activity 3/2022 18/18639 0.166666666666667 1.53635014836795 0.309434783359062 0.70258289979014 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 3/2022 18/18639 0.166666666666667 1.53635014836795 0.309434783359062 0.70258289979014 GO:0070628 proteasome binding 3/2022 18/18639 0.166666666666667 1.53635014836795 0.309434783359062 0.70258289979014 GO:0005227 calcium-activated cation channel activity 4/2022 26/18639 0.153846153846154 1.41816936772426 0.309963044025062 0.70258289979014 GO:0008143 poly(A) binding 4/2022 26/18639 0.153846153846154 1.41816936772426 0.309963044025062 0.70258289979014 GO:0008157 protein phosphatase 1 binding 4/2022 26/18639 0.153846153846154 1.41816936772426 0.309963044025062 0.70258289979014 GO:0015216 purine nucleotide transmembrane transporter activity 4/2022 26/18639 0.153846153846154 1.41816936772426 0.309963044025062 0.70258289979014 GO:0050681 nuclear androgen receptor binding 4/2022 26/18639 0.153846153846154 1.41816936772426 0.309963044025062 0.70258289979014 GO:0070412 R-SMAD binding 4/2022 26/18639 0.153846153846154 1.41816936772426 0.309963044025062 0.70258289979014 GO:0005048 signal sequence binding 7/2022 51/18639 0.137254901960784 1.26522953395008 0.314422322603771 0.710131565234371 GO:0016830 carbon-carbon lyase activity 7/2022 51/18639 0.137254901960784 1.26522953395008 0.314422322603771 0.710131565234371 GO:0042562 hormone binding 12/2022 94/18639 0.127659574468085 1.17677883704779 0.319971293852932 0.7213689743136 GO:0061134 peptidase regulator activity 27/2022 226/18639 0.119469026548673 1.10127753998057 0.326717024401807 0.735259421641275 GO:0010485 histone H4 acetyltransferase activity 5/2022 35/18639 0.142857142857143 1.31687155574396 0.328930745210147 0.738568377301898 GO:0015085 calcium ion transmembrane transporter activity 18/2022 147/18639 0.122448979591837 1.12874704778054 0.329361573661657 0.738568377301898 GO:0016829 lyase activity 24/2022 200/18639 0.12 1.10617210682493 0.331292612381443 0.73992910377937 GO:0004364 glutathione transferase activity 4/2022 27/18639 0.148148148148148 1.36564457632707 0.335647793809537 0.73992910377937 GO:0023026 MHC class II protein complex binding 4/2022 27/18639 0.148148148148148 1.36564457632707 0.335647793809537 0.73992910377937 GO:0035255 ionotropic glutamate receptor binding 4/2022 27/18639 0.148148148148148 1.36564457632707 0.335647793809537 0.73992910377937 GO:0030295 protein kinase activator activity 17/2022 139/18639 0.122302158273381 1.12739363405418 0.337733381318336 0.73992910377937 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/2022 11/18639 0.181818181818182 1.67601834367413 0.338754415629157 0.73992910377937 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 2/2022 11/18639 0.181818181818182 1.67601834367413 0.338754415629157 0.73992910377937 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/2022 11/18639 0.181818181818182 1.67601834367413 0.338754415629157 0.73992910377937 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/2022 11/18639 0.181818181818182 1.67601834367413 0.338754415629157 0.73992910377937 GO:0050786 RAGE receptor binding 2/2022 11/18639 0.181818181818182 1.67601834367413 0.338754415629157 0.73992910377937 GO:0140537 transcription regulator activator activity 2/2022 11/18639 0.181818181818182 1.67601834367413 0.338754415629157 0.73992910377937 GO:0180030 inositol phosphate kinase activity 2/2022 11/18639 0.181818181818182 1.67601834367413 0.338754415629157 0.73992910377937 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/2022 19/18639 0.157894736842105 1.45548961424332 0.340555604998613 0.73992910377937 GO:0031420 alkali metal ion binding 3/2022 19/18639 0.157894736842105 1.45548961424332 0.340555604998613 0.73992910377937 GO:0042800 histone H3K4 methyltransferase activity 3/2022 19/18639 0.157894736842105 1.45548961424332 0.340555604998613 0.73992910377937 GO:0043395 heparan sulfate proteoglycan binding 3/2022 19/18639 0.157894736842105 1.45548961424332 0.340555604998613 0.73992910377937 GO:0046624 sphingolipid transporter activity 3/2022 19/18639 0.157894736842105 1.45548961424332 0.340555604998613 0.73992910377937 GO:0140036 ubiquitin-modified protein reader activity 3/2022 19/18639 0.157894736842105 1.45548961424332 0.340555604998613 0.73992910377937 GO:0019205 nucleobase-containing compound kinase activity 6/2022 44/18639 0.136363636363636 1.2570137577556 0.341702109636963 0.741140092971206 GO:0008081 phosphoric diester hydrolase activity 11/2022 87/18639 0.126436781609195 1.16550700910672 0.342588156066609 0.741782960984155 GO:0016407 acetyltransferase activity 12/2022 96/18639 0.125 1.15226261127596 0.346761412590171 0.749528963983565 GO:0004252 serine-type endopeptidase activity 21/2022 176/18639 0.119318181818182 1.09988703803615 0.355682643484065 0.767493594344688 GO:0036408 histone H3K14 acetyltransferase activity 4/2022 28/18639 0.142857142857143 1.31687155574396 0.361410169167588 0.774093121263078 GO:0046875 ephrin receptor binding 4/2022 28/18639 0.142857142857143 1.31687155574396 0.361410169167588 0.774093121263078 GO:0050698 proteoglycan sulfotransferase activity 4/2022 28/18639 0.142857142857143 1.31687155574396 0.361410169167588 0.774093121263078 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/2022 28/18639 0.142857142857143 1.31687155574396 0.361410169167588 0.774093121263078 GO:0141110 transporter inhibitor activity 6/2022 45/18639 0.133333333333333 1.22908011869436 0.361817770510882 0.774093121263078 GO:0004679 AMP-activated protein kinase activity 29/2022 248/18639 0.116935483870968 1.07792308796784 0.362676197429191 0.774612319806321 GO:0052745 inositol phosphate phosphatase activity 3/2022 20/18639 0.15 1.38271513353116 0.371566214844842 0.783316296323327 GO:0061608 nuclear import signal receptor activity 3/2022 20/18639 0.15 1.38271513353116 0.371566214844842 0.783316296323327 GO:0019213 deacetylase activity 5/2022 37/18639 0.135135135135135 1.24568930948753 0.373793651795384 0.783316296323327 GO:0030551 cyclic nucleotide binding 5/2022 37/18639 0.135135135135135 1.24568930948753 0.373793651795384 0.783316296323327 GO:0003995 acyl-CoA dehydrogenase activity 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:0005095 GTPase inhibitor activity 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:0005165 neurotrophin receptor binding 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:0008504 monoamine transmembrane transporter activity 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:0016208 AMP binding 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:0016801 hydrolase activity, acting on ether bonds 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:0016803 ether hydrolase activity 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:0035197 siRNA binding 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:0036009 protein-glutamine N-methyltransferase activity 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:0042301 phosphate ion binding 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:0043047 single-stranded telomeric DNA binding 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:0070410 co-SMAD binding 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:0140829 bicarbonate:monoatomic anion antiporter activity 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:0140900 chloride:bicarbonate antiporter activity 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/2022 12/18639 0.166666666666667 1.53635014836795 0.37982745688174 0.783316296323327 GO:0004180 carboxypeptidase activity 6/2022 46/18639 0.130434782608696 1.20236098567927 0.38199428466673 0.786495597562597 GO:0141108 transporter regulator activity 20/2022 170/18639 0.117647058823529 1.0844824576715 0.385310073597899 0.789329533258823 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 4/2022 29/18639 0.137931034482759 1.27146219175279 0.387135391113429 0.789329533258823 GO:0005416 amino acid:monoatomic cation symporter activity 4/2022 29/18639 0.137931034482759 1.27146219175279 0.387135391113429 0.789329533258823 GO:0010484 histone H3 acetyltransferase activity 4/2022 29/18639 0.137931034482759 1.27146219175279 0.387135391113429 0.789329533258823 GO:0097472 cyclin-dependent protein kinase activity 4/2022 29/18639 0.137931034482759 1.27146219175279 0.387135391113429 0.789329533258823 GO:0106222 lncRNA binding 4/2022 29/18639 0.137931034482759 1.27146219175279 0.387135391113429 0.789329533258823 GO:0140313 molecular sequestering activity 7/2022 55/18639 0.127272727272727 1.17321284057189 0.387788892104852 0.789382566776544 GO:0043539 protein serine/threonine kinase activator activity 9/2022 73/18639 0.123287671232877 1.13647819194342 0.395299513567047 0.796716650381249 GO:0000146 microfilament motor activity 5/2022 38/18639 0.131578947368421 1.21290801186944 0.396250879137149 0.796716650381249 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 28/2022 243/18639 0.11522633744856 1.06216800380994 0.396938131410273 0.796716650381249 GO:0001784 phosphotyrosine residue binding 6/2022 47/18639 0.127659574468085 1.17677883704779 0.402176859878524 0.796716650381249 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 3/2022 21/18639 0.142857142857143 1.31687155574396 0.402286096175587 0.796716650381249 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 3/2022 21/18639 0.142857142857143 1.31687155574396 0.402286096175587 0.796716650381249 GO:0010314 phosphatidylinositol-5-phosphate binding 3/2022 21/18639 0.142857142857143 1.31687155574396 0.402286096175587 0.796716650381249 GO:0072542 protein phosphatase activator activity 3/2022 21/18639 0.142857142857143 1.31687155574396 0.402286096175587 0.796716650381249 GO:0019783 ubiquitin-like protein peptidase activity 15/2022 127/18639 0.118110236220472 1.08875207364658 0.404328970734356 0.796716650381249 GO:0022839 monoatomic ion-gated channel activity 4/2022 30/18639 0.133333333333333 1.22908011869436 0.412717488400323 0.796716650381249 GO:0043995 histone H4K5 acetyltransferase activity 4/2022 30/18639 0.133333333333333 1.22908011869436 0.412717488400323 0.796716650381249 GO:0043996 histone H4K8 acetyltransferase activity 4/2022 30/18639 0.133333333333333 1.22908011869436 0.412717488400323 0.796716650381249 GO:0043997 histone H4K12 acetyltransferase activity 4/2022 30/18639 0.133333333333333 1.22908011869436 0.412717488400323 0.796716650381249 GO:0043178 alcohol binding 11/2022 92/18639 0.119565217391304 1.10216423687266 0.414178347515601 0.796716650381249 GO:0004676 3-phosphoinositide-dependent protein kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:0004711 ribosomal protein S6 kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:0035175 histone H3S10 kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:0035979 histone H2AXS139 kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:0044022 histone H3S28 kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:0044023 histone H4S1 kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:0044024 histone H2AS1 kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:0044025 histone H2BS14 kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:0072354 histone H3T3 kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:0072371 histone H2AS121 kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:0072518 Rho-dependent protein serine/threonine kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:0140823 histone H2BS36 kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:0140855 histone H3S57 kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:0140995 histone H2A kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:0140997 histone H4 kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:0140998 histone H2B kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:1990244 histone H2AT120 kinase activity 28/2022 245/18639 0.114285714285714 1.05349724459517 0.414532026384956 0.796716650381249 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 15/2022 128/18639 0.1171875 1.08024619807122 0.416533628298456 0.796716650381249 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 5/2022 39/18639 0.128205128205128 1.18180780643689 0.418628494845605 0.796716650381249 GO:0004465 lipoprotein lipase activity 2/2022 13/18639 0.153846153846154 1.41816936772426 0.419775332902277 0.796716650381249 GO:0008035 high-density lipoprotein particle binding 2/2022 13/18639 0.153846153846154 1.41816936772426 0.419775332902277 0.796716650381249 GO:0019104 DNA N-glycosylase activity 2/2022 13/18639 0.153846153846154 1.41816936772426 0.419775332902277 0.796716650381249 GO:0046974 histone H3K9 methyltransferase activity 2/2022 13/18639 0.153846153846154 1.41816936772426 0.419775332902277 0.796716650381249 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/2022 13/18639 0.153846153846154 1.41816936772426 0.419775332902277 0.796716650381249 GO:0070700 BMP receptor binding 2/2022 13/18639 0.153846153846154 1.41816936772426 0.419775332902277 0.796716650381249 GO:0089720 caspase binding 2/2022 13/18639 0.153846153846154 1.41816936772426 0.419775332902277 0.796716650381249 GO:0097157 pre-mRNA intronic binding 2/2022 13/18639 0.153846153846154 1.41816936772426 0.419775332902277 0.796716650381249 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/2022 13/18639 0.153846153846154 1.41816936772426 0.419775332902277 0.796716650381249 GO:0140852 histone ubiquitin ligase activity 2/2022 13/18639 0.153846153846154 1.41816936772426 0.419775332902277 0.796716650381249 GO:0004677 DNA-dependent protein kinase activity 28/2022 246/18639 0.113821138211382 1.0492147354708 0.423357930845677 0.796716650381249 GO:0140857 histone H3T45 kinase activity 28/2022 246/18639 0.113821138211382 1.0492147354708 0.423357930845677 0.796716650381249 GO:0035402 histone H3T11 kinase activity 28/2022 247/18639 0.11336032388664 1.04496690253367 0.43219717254246 0.796716650381249 GO:0035403 histone H3T6 kinase activity 28/2022 247/18639 0.11336032388664 1.04496690253367 0.43219717254246 0.796716650381249 GO:0005243 gap junction channel activity 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0031683 G-protein beta/gamma-subunit complex binding 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0032931 histone H3K56 acetyltransferase activity 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0043992 histone H3K9 acetyltransferase activity 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0043993 histone H3K18 acetyltransferase activity 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0043994 histone H3K23 acetyltransferase activity 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0043999 histone H2AK5 acetyltransferase activity 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0044012 histone H2AK9 acetyltransferase activity 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0044014 histone H2BK5 acetyltransferase activity 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0044015 histone H2BK12 acetyltransferase activity 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0044016 histone H3K4 acetyltransferase activity 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0044017 histone H3K27 acetyltransferase activity 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0044018 histone H3K36 acetyltransferase activity 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0046972 histone H4K16 acetyltransferase activity 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0050321 tau-protein kinase activity 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0070034 telomerase RNA binding 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0140035 ubiquitin-like protein reader activity 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0140908 histone H3K122 acetyltransferase activity 3/2022 22/18639 0.136363636363636 1.2570137577556 0.432557609070265 0.796716650381249 GO:0016763 pentosyltransferase activity 6/2022 49/18639 0.122448979591837 1.12874704778054 0.442353331651912 0.813567969617114 GO:0008276 protein methyltransferase activity 11/2022 95/18639 0.115789473684211 1.0673590504451 0.457344799081958 0.822807015499745 GO:0005161 platelet-derived growth factor receptor binding 2/2022 14/18639 0.142857142857143 1.31687155574396 0.458358798575536 0.822807015499745 GO:0008174 mRNA methyltransferase activity 2/2022 14/18639 0.142857142857143 1.31687155574396 0.458358798575536 0.822807015499745 GO:0008195 phosphatidate phosphatase activity 2/2022 14/18639 0.142857142857143 1.31687155574396 0.458358798575536 0.822807015499745 GO:0008474 palmitoyl-(protein) hydrolase activity 2/2022 14/18639 0.142857142857143 1.31687155574396 0.458358798575536 0.822807015499745 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/2022 14/18639 0.142857142857143 1.31687155574396 0.458358798575536 0.822807015499745 GO:0030983 mismatched DNA binding 2/2022 14/18639 0.142857142857143 1.31687155574396 0.458358798575536 0.822807015499745 GO:0071933 Arp2/3 complex binding 2/2022 14/18639 0.142857142857143 1.31687155574396 0.458358798575536 0.822807015499745 GO:0098599 palmitoyl hydrolase activity 2/2022 14/18639 0.142857142857143 1.31687155574396 0.458358798575536 0.822807015499745 GO:0098847 sequence-specific single stranded DNA binding 2/2022 14/18639 0.142857142857143 1.31687155574396 0.458358798575536 0.822807015499745 GO:1901612 cardiolipin binding 2/2022 14/18639 0.142857142857143 1.31687155574396 0.458358798575536 0.822807015499745 GO:0016209 antioxidant activity 10/2022 86/18639 0.116279069767442 1.07187219653578 0.458396593291 0.822807015499745 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 7/2022 59/18639 0.11864406779661 1.0936729869738 0.461405424455921 0.822807015499745 GO:0031593 polyubiquitin modification-dependent protein binding 7/2022 59/18639 0.11864406779661 1.0936729869738 0.461405424455921 0.822807015499745 GO:0036002 pre-mRNA binding 7/2022 59/18639 0.11864406779661 1.0936729869738 0.461405424455921 0.822807015499745 GO:0045309 protein phosphorylated amino acid binding 7/2022 59/18639 0.11864406779661 1.0936729869738 0.461405424455921 0.822807015499745 GO:0042171 lysophosphatidic acid acyltransferase activity 3/2022 23/18639 0.130434782608696 1.20236098567927 0.462245057538249 0.822807015499745 GO:0044013 histone H2B acetyltransferase activity 3/2022 23/18639 0.130434782608696 1.20236098567927 0.462245057538249 0.822807015499745 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 3/2022 23/18639 0.130434782608696 1.20236098567927 0.462245057538249 0.822807015499745 GO:0071617 lysophospholipid acyltransferase activity 3/2022 23/18639 0.130434782608696 1.20236098567927 0.462245057538249 0.822807015499745 GO:0099186 structural constituent of postsynapse 3/2022 23/18639 0.130434782608696 1.20236098567927 0.462245057538249 0.822807015499745 GO:0017080 sodium channel regulator activity 5/2022 41/18639 0.121951219512195 1.12415864514728 0.462882008301555 0.822807015499745 GO:0042169 SH2 domain binding 5/2022 41/18639 0.121951219512195 1.12415864514728 0.462882008301555 0.822807015499745 GO:0120015 sterol transfer activity 4/2022 32/18639 0.125 1.15226261127596 0.463074218580143 0.822807015499745 GO:0030414 peptidase inhibitor activity 19/2022 169/18639 0.112426035502959 1.03635453795235 0.47077615850396 0.835312281238338 GO:0008080 N-acetyltransferase activity 8/2022 69/18639 0.115942028985507 1.06876532060379 0.477359985445348 0.845801213648236 GO:0004866 endopeptidase inhibitor activity 18/2022 161/18639 0.111801242236025 1.03059513058223 0.483402932939355 0.851390522449884 GO:0004402 histone acetyltransferase activity 5/2022 42/18639 0.119047619047619 1.09739296311997 0.484638654336726 0.851390522449884 GO:0008307 structural constituent of muscle 5/2022 42/18639 0.119047619047619 1.09739296311997 0.484638654336726 0.851390522449884 GO:0016859 cis-trans isomerase activity 5/2022 42/18639 0.119047619047619 1.09739296311997 0.484638654336726 0.851390522449884 GO:0019956 chemokine binding 4/2022 33/18639 0.121212121212121 1.11734556244942 0.487682956735336 0.851390522449884 GO:0030296 protein tyrosine kinase activator activity 4/2022 33/18639 0.121212121212121 1.11734556244942 0.487682956735336 0.851390522449884 GO:0016853 isomerase activity 20/2022 180/18639 0.111111111111111 1.0242334322453 0.490193642618221 0.851390522449884 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 3/2022 24/18639 0.125 1.15226261127596 0.491233483754131 0.851390522449884 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 3/2022 24/18639 0.125 1.15226261127596 0.491233483754131 0.851390522449884 GO:0004622 lysophospholipase activity 3/2022 24/18639 0.125 1.15226261127596 0.491233483754131 0.851390522449884 GO:0005315 phosphate transmembrane transporter activity 3/2022 24/18639 0.125 1.15226261127596 0.491233483754131 0.851390522449884 GO:0043998 histone H2A acetyltransferase activity 3/2022 24/18639 0.125 1.15226261127596 0.491233483754131 0.851390522449884 GO:0048027 mRNA 5'-UTR binding 3/2022 24/18639 0.125 1.15226261127596 0.491233483754131 0.851390522449884 GO:0070300 phosphatidic acid binding 3/2022 24/18639 0.125 1.15226261127596 0.491233483754131 0.851390522449884 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 3/2022 24/18639 0.125 1.15226261127596 0.491233483754131 0.851390522449884 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/2022 15/18639 0.133333333333333 1.22908011869436 0.495403706226801 0.851390522449884 GO:0031386 protein tag activity 2/2022 15/18639 0.133333333333333 1.22908011869436 0.495403706226801 0.851390522449884 GO:0033130 acetylcholine receptor binding 2/2022 15/18639 0.133333333333333 1.22908011869436 0.495403706226801 0.851390522449884 GO:0140161 monocarboxylate:sodium symporter activity 2/2022 15/18639 0.133333333333333 1.22908011869436 0.495403706226801 0.851390522449884 GO:0141047 molecular tag activity 2/2022 15/18639 0.133333333333333 1.22908011869436 0.495403706226801 0.851390522449884 GO:0141050 histone H3K deacetylase activity 2/2022 15/18639 0.133333333333333 1.22908011869436 0.495403706226801 0.851390522449884 GO:0141051 histone H4K deacetylase activity 2/2022 15/18639 0.133333333333333 1.22908011869436 0.495403706226801 0.851390522449884 GO:0019905 syntaxin binding 7/2022 61/18639 0.114754098360656 1.05781485625334 0.497535567388198 0.853887781411124 GO:0030159 signaling receptor complex adaptor activity 6/2022 52/18639 0.115384615384615 1.0636270257932 0.501443827455392 0.859422799644255 GO:0048156 tau protein binding 5/2022 43/18639 0.116279069767442 1.07187219653578 0.506077395210397 0.866184167584598 GO:0016831 carboxy-lyase activity 4/2022 34/18639 0.117647058823529 1.0844824576715 0.511816608426736 0.873629977477387 GO:0030332 cyclin binding 4/2022 34/18639 0.117647058823529 1.0844824576715 0.511816608426736 0.873629977477387 GO:0042826 histone deacetylase binding 14/2022 127/18639 0.110236220472441 1.01616860207014 0.516845216165934 0.881017997204261 GO:0019211 phosphatase activator activity 3/2022 25/18639 0.12 1.10617210682493 0.519427281804313 0.882738394769731 GO:0042974 nuclear retinoic acid receptor binding 3/2022 25/18639 0.12 1.10617210682493 0.519427281804313 0.882738394769731 GO:0017046 peptide hormone binding 6/2022 53/18639 0.113207547169811 1.04355859134427 0.520661278950032 0.882738394769731 GO:0034212 protein N-acetyltransferase activity 6/2022 53/18639 0.113207547169811 1.04355859134427 0.520661278950032 0.882738394769731 GO:0030971 receptor tyrosine kinase binding 9/2022 81/18639 0.111111111111111 1.0242334322453 0.522297357552054 0.884320425034298 GO:0016248 channel inhibitor activity 5/2022 44/18639 0.113636363636364 1.04751146479633 0.527151149771094 0.886517197275451 GO:0043014 alpha-tubulin binding 5/2022 44/18639 0.113636363636364 1.04751146479633 0.527151149771094 0.886517197275451 GO:0000062 fatty-acyl-CoA binding 2/2022 16/18639 0.125 1.15226261127596 0.530789708541878 0.886517197275451 GO:0008142 oxysterol binding 2/2022 16/18639 0.125 1.15226261127596 0.530789708541878 0.886517197275451 GO:0015378 sodium:chloride symporter activity 2/2022 16/18639 0.125 1.15226261127596 0.530789708541878 0.886517197275451 GO:0017070 U6 snRNA binding 2/2022 16/18639 0.125 1.15226261127596 0.530789708541878 0.886517197275451 GO:0022841 potassium ion leak channel activity 2/2022 16/18639 0.125 1.15226261127596 0.530789708541878 0.886517197275451 GO:0030275 LRR domain binding 2/2022 16/18639 0.125 1.15226261127596 0.530789708541878 0.886517197275451 GO:0043023 ribosomal large subunit binding 2/2022 16/18639 0.125 1.15226261127596 0.530789708541878 0.886517197275451 GO:0055102 lipase inhibitor activity 2/2022 16/18639 0.125 1.15226261127596 0.530789708541878 0.886517197275451 GO:0061135 endopeptidase regulator activity 20/2022 184/18639 0.108695652173913 1.00196748806606 0.531600605490373 0.886517197275451 GO:0004857 enzyme inhibitor activity 45/2022 416/18639 0.108173076923077 0.997150336681123 0.532051259096157 0.886517197275451 GO:0061631 ubiquitin conjugating enzyme activity 4/2022 35/18639 0.114285714285714 1.05349724459517 0.535414784325651 0.889764595352271 GO:0140566 histone reader activity 4/2022 35/18639 0.114285714285714 1.05349724459517 0.535414784325651 0.889764595352271 GO:0051287 NAD binding 6/2022 54/18639 0.111111111111111 1.0242334322453 0.539578920899515 0.895501691941412 GO:0004112 cyclic-nucleotide phosphodiesterase activity 3/2022 26/18639 0.115384615384615 1.0636270257932 0.546748704123345 0.901454613089343 GO:0008198 ferrous iron binding 3/2022 26/18639 0.115384615384615 1.0636270257932 0.546748704123345 0.901454613089343 GO:0030247 polysaccharide binding 3/2022 26/18639 0.115384615384615 1.0636270257932 0.546748704123345 0.901454613089343 GO:0043548 phosphatidylinositol 3-kinase binding 3/2022 26/18639 0.115384615384615 1.0636270257932 0.546748704123345 0.901454613089343 GO:0097602 cullin family protein binding 3/2022 26/18639 0.115384615384615 1.0636270257932 0.546748704123345 0.901454613089343 GO:0051539 4 iron, 4 sulfur cluster binding 5/2022 45/18639 0.111111111111111 1.0242334322453 0.547817822178621 0.902035105105635 GO:0140767 enzyme-substrate adaptor activity 15/2022 139/18639 0.107913669064748 0.994759088871336 0.549185205909679 0.90310456082925 GO:1902936 phosphatidylinositol bisphosphate binding 12/2022 111/18639 0.108108108108108 0.996551447590023 0.550356019542329 0.903848397629569 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 9/2022 83/18639 0.108433734939759 0.99955310857674 0.552808087604034 0.905696850702948 GO:0016298 lipase activity 14/2022 130/18639 0.107692307692308 0.992718557406985 0.553507760357596 0.905696850702948 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 4/2022 36/18639 0.111111111111111 1.0242334322453 0.558425590286531 0.905696850702948 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 4/2022 36/18639 0.111111111111111 1.0242334322453 0.558425590286531 0.905696850702948 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 4/2022 36/18639 0.111111111111111 1.0242334322453 0.558425590286531 0.905696850702948 GO:0016247 channel regulator activity 18/2022 168/18639 0.107142857142857 0.987653666807969 0.559334583594856 0.905696850702948 GO:0031491 nucleosome binding 8/2022 74/18639 0.108108108108108 0.996551447590023 0.559438045342546 0.905696850702948 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/2022 17/18639 0.117647058823529 1.0844824576715 0.564440644635223 0.905696850702948 GO:0016018 cyclosporin A binding 2/2022 17/18639 0.117647058823529 1.0844824576715 0.564440644635223 0.905696850702948 GO:0017110 nucleoside diphosphate phosphatase activity 2/2022 17/18639 0.117647058823529 1.0844824576715 0.564440644635223 0.905696850702948 GO:0036041 long-chain fatty acid binding 2/2022 17/18639 0.117647058823529 1.0844824576715 0.564440644635223 0.905696850702948 GO:0045125 bioactive lipid receptor activity 2/2022 17/18639 0.117647058823529 1.0844824576715 0.564440644635223 0.905696850702948 GO:0046965 nuclear retinoid X receptor binding 2/2022 17/18639 0.117647058823529 1.0844824576715 0.564440644635223 0.905696850702948 GO:0070402 NADPH binding 2/2022 17/18639 0.117647058823529 1.0844824576715 0.564440644635223 0.905696850702948 GO:0070403 NAD+ binding 2/2022 17/18639 0.117647058823529 1.0844824576715 0.564440644635223 0.905696850702948 GO:0070492 oligosaccharide binding 2/2022 17/18639 0.117647058823529 1.0844824576715 0.564440644635223 0.905696850702948 GO:1901567 fatty acid derivative binding 2/2022 17/18639 0.117647058823529 1.0844824576715 0.564440644635223 0.905696850702948 GO:1990226 histone methyltransferase binding 2/2022 17/18639 0.117647058823529 1.0844824576715 0.564440644635223 0.905696850702948 GO:0005262 calcium channel activity 14/2022 131/18639 0.106870229007634 0.985140553151969 0.565512869758781 0.906261388734455 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 5/2022 46/18639 0.108695652173913 1.00196748806606 0.568040204802022 0.909153406667867 GO:0004722 protein serine/threonine phosphatase activity 11/2022 103/18639 0.106796116504854 0.984457376624125 0.569026154857798 0.909574209416911 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 13/2022 122/18639 0.10655737704918 0.982256652235248 0.57060894037498 0.910946760141782 GO:0004683 calcium/calmodulin-dependent protein kinase activity 3/2022 27/18639 0.111111111111111 1.0242334322453 0.573136317912572 0.911511362748439 GO:0008266 poly(U) RNA binding 3/2022 27/18639 0.111111111111111 1.0242334322453 0.573136317912572 0.911511362748439 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 3/2022 27/18639 0.111111111111111 1.0242334322453 0.573136317912572 0.911511362748439 GO:0099106 ion channel regulator activity 17/2022 160/18639 0.10625 0.97942321958457 0.574198398619992 0.912047456393876 GO:0016410 N-acyltransferase activity 10/2022 94/18639 0.106382978723404 0.980649030873161 0.575359037389694 0.912738548595505 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 14/2022 132/18639 0.106060606060606 0.977677367143243 0.577394604808151 0.914814121975635 GO:0061733 protein-lysine-acetyltransferase activity 5/2022 47/18639 0.106382978723404 0.980649030873161 0.587785841102438 0.930106400134424 GO:0004601 peroxidase activity 6/2022 57/18639 0.105263157894737 0.970326409495549 0.594235740553657 0.930727050417851 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/2022 18/18639 0.111111111111111 1.0242334322453 0.596316377294744 0.930727050417851 GO:0008409 5'-3' exonuclease activity 2/2022 18/18639 0.111111111111111 1.0242334322453 0.596316377294744 0.930727050417851 GO:0015373 monoatomic anion:sodium symporter activity 2/2022 18/18639 0.111111111111111 1.0242334322453 0.596316377294744 0.930727050417851 GO:0016854 racemase and epimerase activity 2/2022 18/18639 0.111111111111111 1.0242334322453 0.596316377294744 0.930727050417851 GO:0017075 syntaxin-1 binding 2/2022 18/18639 0.111111111111111 1.0242334322453 0.596316377294744 0.930727050417851 GO:0031690 adrenergic receptor binding 2/2022 18/18639 0.111111111111111 1.0242334322453 0.596316377294744 0.930727050417851 GO:0035615 clathrin adaptor activity 2/2022 18/18639 0.111111111111111 1.0242334322453 0.596316377294744 0.930727050417851 GO:0050811 GABA receptor binding 2/2022 18/18639 0.111111111111111 1.0242334322453 0.596316377294744 0.930727050417851 GO:0098641 cadherin binding involved in cell-cell adhesion 2/2022 18/18639 0.111111111111111 1.0242334322453 0.596316377294744 0.930727050417851 GO:1901611 phosphatidylglycerol binding 2/2022 18/18639 0.111111111111111 1.0242334322453 0.596316377294744 0.930727050417851 GO:0046625 sphingolipid binding 3/2022 28/18639 0.107142857142857 0.987653666807969 0.59854345576197 0.933045436615314 GO:0042054 histone methyltransferase activity 7/2022 67/18639 0.104477611940299 0.963085167633642 0.600255680557456 0.934556492749108 GO:0003724 RNA helicase activity 8/2022 77/18639 0.103896103896104 0.957724767813789 0.605917181161122 0.940873431631749 GO:0140693 molecular condensate scaffold activity 5/2022 48/18639 0.104166666666667 0.96021884272997 0.607026855390819 0.940873431631749 GO:0003777 microtubule motor activity 7/2022 68/18639 0.102941176470588 0.948922150462559 0.616298957522149 0.940873431631749 GO:0004181 metallocarboxypeptidase activity 3/2022 29/18639 0.103448275862069 0.953596643814591 0.622936693990648 0.940873431631749 GO:0004629 phospholipase C activity 3/2022 29/18639 0.103448275862069 0.953596643814591 0.622936693990648 0.940873431631749 GO:0099604 ligand-gated calcium channel activity 3/2022 29/18639 0.103448275862069 0.953596643814591 0.622936693990648 0.940873431631749 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 4/2022 39/18639 0.102564102564103 0.945446245149509 0.623533380169684 0.940873431631749 GO:0035254 glutamate receptor binding 5/2022 49/18639 0.102040816326531 0.940622539817114 0.625739755815695 0.940873431631749 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/2022 19/18639 0.105263157894737 0.970326409495549 0.626405879917818 0.940873431631749 GO:0005229 intracellularly calcium-gated chloride channel activity 2/2022 19/18639 0.105263157894737 0.970326409495549 0.626405879917818 0.940873431631749 GO:0022840 leak channel activity 2/2022 19/18639 0.105263157894737 0.970326409495549 0.626405879917818 0.940873431631749 GO:0022842 narrow pore channel activity 2/2022 19/18639 0.105263157894737 0.970326409495549 0.626405879917818 0.940873431631749 GO:0050145 nucleoside monophosphate kinase activity 2/2022 19/18639 0.105263157894737 0.970326409495549 0.626405879917818 0.940873431631749 GO:0097001 ceramide binding 2/2022 19/18639 0.105263157894737 0.970326409495549 0.626405879917818 0.940873431631749 GO:0120227 acyl-CoA binding 2/2022 19/18639 0.105263157894737 0.970326409495549 0.626405879917818 0.940873431631749 GO:0141147 intracellularly calcium-gated channel activity 2/2022 19/18639 0.105263157894737 0.970326409495549 0.626405879917818 0.940873431631749 GO:0004879 nuclear receptor activity 6/2022 59/18639 0.101694915254237 0.937433988834683 0.628683814364386 0.940873431631749 GO:0016279 protein-lysine N-methyltransferase activity 7/2022 69/18639 0.101449275362319 0.935169655528319 0.631985615659853 0.940873431631749 GO:0008186 ATP-dependent activity, acting on RNA 8/2022 79/18639 0.10126582278481 0.933478571160275 0.635457916094772 0.940873431631749 GO:0033293 monocarboxylic acid binding 8/2022 79/18639 0.10126582278481 0.933478571160275 0.635457916094772 0.940873431631749 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4/2022 40/18639 0.1 0.921810089020772 0.64383046982586 0.940873431631749 GO:0001098 basal transcription machinery binding 6/2022 60/18639 0.1 0.921810089020772 0.645253598184765 0.940873431631749 GO:0001099 basal RNA polymerase II transcription machinery binding 6/2022 60/18639 0.1 0.921810089020772 0.645253598184765 0.940873431631749 GO:0098531 ligand-modulated transcription factor activity 6/2022 60/18639 0.1 0.921810089020772 0.645253598184765 0.940873431631749 GO:0001965 G-protein alpha-subunit binding 3/2022 30/18639 0.1 0.921810089020772 0.646294383500684 0.940873431631749 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 3/2022 30/18639 0.1 0.921810089020772 0.646294383500684 0.940873431631749 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/2022 30/18639 0.1 0.921810089020772 0.646294383500684 0.940873431631749 GO:0008187 poly-pyrimidine tract binding 3/2022 30/18639 0.1 0.921810089020772 0.646294383500684 0.940873431631749 GO:0033612 receptor serine/threonine kinase binding 3/2022 30/18639 0.1 0.921810089020772 0.646294383500684 0.940873431631749 GO:0051721 protein phosphatase 2A binding 3/2022 30/18639 0.1 0.921810089020772 0.646294383500684 0.940873431631749 GO:0016278 lysine N-methyltransferase activity 7/2022 70/18639 0.1 0.921810089020772 0.647301999960703 0.940873431631749 GO:0048306 calcium-dependent protein binding 8/2022 80/18639 0.1 0.921810089020772 0.6497552304707 0.940873431631749 GO:0001972 retinoic acid binding 2/2022 20/18639 0.1 0.921810089020772 0.65472139825926 0.940873431631749 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 2/2022 20/18639 0.1 0.921810089020772 0.65472139825926 0.940873431631749 GO:0016408 C-acyltransferase activity 2/2022 20/18639 0.1 0.921810089020772 0.65472139825926 0.940873431631749 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/2022 20/18639 0.1 0.921810089020772 0.65472139825926 0.940873431631749 GO:0030742 GTP-dependent protein binding 2/2022 20/18639 0.1 0.921810089020772 0.65472139825926 0.940873431631749 GO:0042288 MHC class I protein binding 2/2022 20/18639 0.1 0.921810089020772 0.65472139825926 0.940873431631749 GO:0140939 histone H4 methyltransferase activity 2/2022 20/18639 0.1 0.921810089020772 0.65472139825926 0.940873431631749 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 6/2022 61/18639 0.0983606557377049 0.906698448217152 0.661368292453482 0.940873431631749 GO:0016836 hydro-lyase activity 6/2022 61/18639 0.0983606557377049 0.906698448217152 0.661368292453482 0.940873431631749 GO:0140299 molecular sensor activity 7/2022 71/18639 0.0985915492957746 0.908826848330338 0.662236433526172 0.940873431631749 GO:0042287 MHC protein binding 4/2022 41/18639 0.0975609756097561 0.899326916117826 0.663392465666326 0.940873431631749 GO:0061650 ubiquitin-like protein conjugating enzyme activity 4/2022 41/18639 0.0975609756097561 0.899326916117826 0.663392465666326 0.940873431631749 GO:0033192 calmodulin-dependent protein phosphatase activity 8/2022 81/18639 0.0987654320987654 0.910429717551379 0.663723216543976 0.940873431631749 GO:0140791 histone H2AXS140 phosphatase activity 8/2022 81/18639 0.0987654320987654 0.910429717551379 0.663723216543976 0.940873431631749 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 8/2022 81/18639 0.0987654320987654 0.910429717551379 0.663723216543976 0.940873431631749 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 8/2022 81/18639 0.0987654320987654 0.910429717551379 0.663723216543976 0.940873431631749 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 8/2022 81/18639 0.0987654320987654 0.910429717551379 0.663723216543976 0.940873431631749 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 8/2022 81/18639 0.0987654320987654 0.910429717551379 0.663723216543976 0.940873431631749 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 8/2022 81/18639 0.0987654320987654 0.910429717551379 0.663723216543976 0.940873431631749 GO:1990439 MAP kinase serine/threonine phosphatase activity 8/2022 81/18639 0.0987654320987654 0.910429717551379 0.663723216543976 0.940873431631749 GO:0070273 phosphatidylinositol-4-phosphate binding 3/2022 31/18639 0.0967741935483871 0.892074279697521 0.668605250878882 0.940873431631749 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 8/2022 82/18639 0.0975609756097561 0.899326916117826 0.677353234988195 0.940873431631749 GO:0033549 MAP kinase phosphatase activity 8/2022 82/18639 0.0975609756097561 0.899326916117826 0.677353234988195 0.940873431631749 GO:0001846 opsonin binding 2/2022 21/18639 0.0952380952380952 0.877914370495973 0.681293535320699 0.940873431631749 GO:0005123 death receptor binding 2/2022 21/18639 0.0952380952380952 0.877914370495973 0.681293535320699 0.940873431631749 GO:0009975 cyclase activity 2/2022 21/18639 0.0952380952380952 0.877914370495973 0.681293535320699 0.940873431631749 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/2022 21/18639 0.0952380952380952 0.877914370495973 0.681293535320699 0.940873431631749 GO:0061891 calcium ion sensor activity 2/2022 21/18639 0.0952380952380952 0.877914370495973 0.681293535320699 0.940873431631749 GO:0140312 cargo adaptor activity 2/2022 21/18639 0.0952380952380952 0.877914370495973 0.681293535320699 0.940873431631749 GO:0005200 structural constituent of cytoskeleton 11/2022 112/18639 0.0982142857142857 0.905349194573972 0.681677352161581 0.940873431631749 GO:0043022 ribosome binding 11/2022 112/18639 0.0982142857142857 0.905349194573972 0.681677352161581 0.940873431631749 GO:0019894 kinesin binding 4/2022 42/18639 0.0952380952380952 0.877914370495973 0.682208656332599 0.940873431631749 GO:0048487 beta-tubulin binding 4/2022 42/18639 0.0952380952380952 0.877914370495973 0.682208656332599 0.940873431631749 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0003796 lysozyme activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0004090 carbonyl reductase (NADPH) activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0004935 adrenergic receptor activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0005031 tumor necrosis factor receptor activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0005131 growth hormone receptor binding 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0008140 cAMP response element binding protein binding 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0008401 retinoic acid 4-hydroxylase activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0008519 ammonium channel activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0015187 glycine transmembrane transporter activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0019531 oxalate transmembrane transporter activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0031434 mitogen-activated protein kinase kinase binding 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0031720 haptoglobin binding 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0031996 thioesterase binding 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0032395 MHC class II receptor activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0035256 G protein-coupled glutamate receptor binding 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0035374 chondroitin sulfate binding 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0043422 protein kinase B binding 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0050308 sugar-phosphatase activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0050815 phosphoserine residue binding 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0051378 serotonin binding 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0051880 G-quadruplex DNA binding 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0140135 mechanosensitive monoatomic cation channel activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0140940 histone H2A methyltransferase activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0141109 transporter activator activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:1990259 histone H2AQ104 methyltransferase activity 1/2022 10/18639 0.1 0.921810089020772 0.682917346875223 0.940873431631749 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 12/2022 122/18639 0.0983606557377049 0.906698448217152 0.683591666543258 0.940873431631749 GO:0031369 translation initiation factor binding 3/2022 32/18639 0.09375 0.864196958456973 0.689867081806338 0.946684259070807 GO:0051059 NF-kappaB binding 3/2022 32/18639 0.09375 0.864196958456973 0.689867081806338 0.946684259070807 GO:0008135 translation factor activity, RNA binding 8/2022 83/18639 0.0963855421686747 0.888491652068214 0.690638050709172 0.946684259070807 GO:0005544 calcium-dependent phospholipid binding 5/2022 53/18639 0.0943396226415094 0.869632159453558 0.694981206204909 0.946684259070807 GO:0008146 sulfotransferase activity 5/2022 53/18639 0.0943396226415094 0.869632159453558 0.694981206204909 0.946684259070807 GO:0008200 ion channel inhibitor activity 4/2022 43/18639 0.0930232558139535 0.857497757228625 0.700273401063081 0.946684259070807 GO:0017018 myosin phosphatase activity 8/2022 84/18639 0.0952380952380952 0.877914370495973 0.703571777633561 0.946684259070807 GO:0180051 translation factor activity 8/2022 84/18639 0.0952380952380952 0.877914370495973 0.703571777633561 0.946684259070807 GO:0004407 histone deacetylase activity 2/2022 22/18639 0.0909090909090909 0.838009171837065 0.706167127945742 0.946684259070807 GO:0008970 phospholipase A1 activity 2/2022 22/18639 0.0909090909090909 0.838009171837065 0.706167127945742 0.946684259070807 GO:0016881 acid-amino acid ligase activity 2/2022 22/18639 0.0909090909090909 0.838009171837065 0.706167127945742 0.946684259070807 GO:0033558 protein lysine deacetylase activity 2/2022 22/18639 0.0909090909090909 0.838009171837065 0.706167127945742 0.946684259070807 GO:0061133 endopeptidase activator activity 2/2022 22/18639 0.0909090909090909 0.838009171837065 0.706167127945742 0.946684259070807 GO:0140517 protein-RNA adaptor activity 2/2022 22/18639 0.0909090909090909 0.838009171837065 0.706167127945742 0.946684259070807 GO:0140784 metal ion sensor activity 2/2022 22/18639 0.0909090909090909 0.838009171837065 0.706167127945742 0.946684259070807 GO:0005506 iron ion binding 15/2022 154/18639 0.0974025974025974 0.897866969825427 0.709189094279441 0.946684259070807 GO:0140311 protein sequestering activity 3/2022 33/18639 0.0909090909090909 0.838009171837065 0.710085494313438 0.946684259070807 GO:0000099 sulfur amino acid transmembrane transporter activity 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0004016 adenylate cyclase activity 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0005536 D-glucose binding 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0008199 ferric iron binding 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0008503 benzodiazepine receptor activity 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0016594 glycine binding 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0019107 myristoyltransferase activity 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0019203 carbohydrate phosphatase activity 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0019206 nucleoside kinase activity 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0019864 IgG binding 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0032404 mismatch repair complex binding 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0034511 U3 snoRNA binding 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0043522 leucine zipper domain binding 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0070697 activin receptor binding 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0070990 snRNP binding 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0140031 phosphorylation-dependent protein binding 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/2022 11/18639 0.0909090909090909 0.838009171837065 0.71733363999983 0.946684259070807 GO:0120013 lipid transfer activity 6/2022 65/18639 0.0923076923076923 0.850901620634558 0.721093560370942 0.946684259070807 GO:0015078 proton transmembrane transporter activity 18/2022 185/18639 0.0972972972972973 0.896896302831021 0.722708817525701 0.946684259070807 GO:0000149 SNARE binding 10/2022 106/18639 0.0943396226415094 0.869632159453558 0.725974223183465 0.946684259070807 GO:0004896 cytokine receptor activity 9/2022 96/18639 0.09375 0.864196958456973 0.726815639388606 0.946684259070807 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 8/2022 86/18639 0.0930232558139535 0.857497757228625 0.728368810436701 0.946684259070807 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 3/2022 34/18639 0.0882352941176471 0.813361843253622 0.729272805850861 0.946684259070807 GO:0003887 DNA-directed DNA polymerase activity 2/2022 23/18639 0.0869565217391304 0.801573990452845 0.729397801317884 0.946684259070807 GO:0004022 alcohol dehydrogenase (NAD+) activity 2/2022 23/18639 0.0869565217391304 0.801573990452845 0.729397801317884 0.946684259070807 GO:0005212 structural constituent of eye lens 2/2022 23/18639 0.0869565217391304 0.801573990452845 0.729397801317884 0.946684259070807 GO:0008171 O-methyltransferase activity 2/2022 23/18639 0.0869565217391304 0.801573990452845 0.729397801317884 0.946684259070807 GO:0031681 G-protein beta-subunit binding 2/2022 23/18639 0.0869565217391304 0.801573990452845 0.729397801317884 0.946684259070807 GO:0043274 phospholipase binding 2/2022 23/18639 0.0869565217391304 0.801573990452845 0.729397801317884 0.946684259070807 GO:0017022 myosin binding 7/2022 76/18639 0.0921052631578947 0.849035608308605 0.730899249149337 0.946684259070807 GO:0016874 ligase activity 16/2022 167/18639 0.0958083832335329 0.883171342774392 0.737366207335038 0.946684259070807 GO:0043021 ribonucleoprotein complex binding 17/2022 177/18639 0.096045197740113 0.885354322788312 0.73824180124963 0.946684259070807 GO:0030170 pyridoxal phosphate binding 5/2022 56/18639 0.0892857142857143 0.823044722339975 0.740783655251264 0.946684259070807 GO:0005154 epidermal growth factor receptor binding 3/2022 35/18639 0.0857142857142857 0.790122933446376 0.747446995368849 0.946684259070807 GO:0043015 gamma-tubulin binding 3/2022 35/18639 0.0857142857142857 0.790122933446376 0.747446995368849 0.946684259070807 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0004000 adenosine deaminase activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0004526 ribonuclease P activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0004859 phospholipase inhibitor activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0005436 sodium:phosphate symporter activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0008603 cAMP-dependent protein kinase regulator activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0015132 prostaglandin transmembrane transporter activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0015166 polyol transmembrane transporter activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0015269 calcium-activated potassium channel activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0016273 arginine N-methyltransferase activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0016274 protein-arginine N-methyltransferase activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0016423 tRNA (guanine) methyltransferase activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0035259 nuclear glucocorticoid receptor binding 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0070679 inositol 1,4,5 trisphosphate binding 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0097677 STAT family protein binding 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:1990459 transferrin receptor binding 1/2022 12/18639 0.0833333333333333 0.768175074183976 0.748016020283293 0.946684259070807 GO:0008170 N-methyltransferase activity 9/2022 98/18639 0.0918367346938776 0.846560285835403 0.749086329420521 0.947086032573885 GO:0030291 protein serine/threonine kinase inhibitor activity 4/2022 46/18639 0.0869565217391304 0.801573990452845 0.749968161062498 0.947248942386167 GO:0004806 triacylglycerol lipase activity 2/2022 24/18639 0.0833333333333333 0.768175074183976 0.751049102914589 0.947561305672059 GO:0016651 oxidoreductase activity, acting on NAD(P)H 8/2022 88/18639 0.0909090909090909 0.838009171837065 0.751721926121395 0.947561305672059 GO:0070279 vitamin B6 binding 5/2022 57/18639 0.087719298245614 0.808605341246291 0.754874800895264 0.949770904488957 GO:0004620 phospholipase activity 10/2022 109/18639 0.0917431192660551 0.845697329376855 0.757503846077151 0.949770904488957 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 6/2022 68/18639 0.0882352941176471 0.813361843253622 0.760801402103147 0.949770904488957 GO:0003727 single-stranded RNA binding 8/2022 89/18639 0.0898876404494382 0.828593338445637 0.762854878759648 0.949770904488957 GO:0004033 aldo-keto reductase (NADPH) activity 3/2022 36/18639 0.0833333333333333 0.768175074183976 0.764630759467242 0.949770904488957 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/2022 36/18639 0.0833333333333333 0.768175074183976 0.764630759467242 0.949770904488957 GO:0005484 SNAP receptor activity 3/2022 36/18639 0.0833333333333333 0.768175074183976 0.764630759467242 0.949770904488957 GO:0005504 fatty acid binding 4/2022 47/18639 0.0851063829787234 0.784519224698529 0.765054888500643 0.949770904488957 GO:0000287 magnesium ion binding 22/2022 230/18639 0.0956521739130435 0.881731389498129 0.765381790264933 0.949770904488957 GO:0016835 carbon-oxygen lyase activity 7/2022 79/18639 0.0886075949367089 0.816793749765241 0.76714930806361 0.949770904488957 GO:0015271 outward rectifier potassium channel activity 2/2022 25/18639 0.08 0.737448071216617 0.771190130837222 0.949770904488957 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 2/2022 25/18639 0.08 0.737448071216617 0.771190130837222 0.949770904488957 GO:0002039 p53 binding 6/2022 69/18639 0.0869565217391304 0.801573990452845 0.773069572240603 0.949770904488957 GO:0002161 aminoacyl-tRNA editing activity 1/2022 13/18639 0.0769230769230769 0.709084683862132 0.775369410898378 0.949770904488957 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/2022 13/18639 0.0769230769230769 0.709084683862132 0.775369410898378 0.949770904488957 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/2022 13/18639 0.0769230769230769 0.709084683862132 0.775369410898378 0.949770904488957 GO:0005035 death receptor activity 1/2022 13/18639 0.0769230769230769 0.709084683862132 0.775369410898378 0.949770904488957 GO:0008253 5'-nucleotidase activity 1/2022 13/18639 0.0769230769230769 0.709084683862132 0.775369410898378 0.949770904488957 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/2022 13/18639 0.0769230769230769 0.709084683862132 0.775369410898378 0.949770904488957 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/2022 13/18639 0.0769230769230769 0.709084683862132 0.775369410898378 0.949770904488957 GO:0030955 potassium ion binding 1/2022 13/18639 0.0769230769230769 0.709084683862132 0.775369410898378 0.949770904488957 GO:0035325 Toll-like receptor binding 1/2022 13/18639 0.0769230769230769 0.709084683862132 0.775369410898378 0.949770904488957 GO:0039706 co-receptor binding 1/2022 13/18639 0.0769230769230769 0.709084683862132 0.775369410898378 0.949770904488957 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/2022 13/18639 0.0769230769230769 0.709084683862132 0.775369410898378 0.949770904488957 GO:0045159 myosin II binding 1/2022 13/18639 0.0769230769230769 0.709084683862132 0.775369410898378 0.949770904488957 GO:0071714 icosanoid transmembrane transporter activity 1/2022 13/18639 0.0769230769230769 0.709084683862132 0.775369410898378 0.949770904488957 GO:0071837 HMG box domain binding 1/2022 13/18639 0.0769230769230769 0.709084683862132 0.775369410898378 0.949770904488957 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/2022 13/18639 0.0769230769230769 0.709084683862132 0.775369410898378 0.949770904488957 GO:1901338 catecholamine binding 1/2022 13/18639 0.0769230769230769 0.709084683862132 0.775369410898378 0.949770904488957 GO:0022829 wide pore channel activity 3/2022 37/18639 0.0810810810810811 0.747413585692517 0.780850660079538 0.955199401245951 GO:0015459 potassium channel regulator activity 5/2022 59/18639 0.0847457627118644 0.781194990695569 0.781319701019144 0.955199401245951 GO:0004529 DNA exonuclease activity 2/2022 26/18639 0.0769230769230769 0.709084683862132 0.789893583063378 0.960011061078552 GO:0051139 metal cation:proton antiporter activity 2/2022 26/18639 0.0769230769230769 0.709084683862132 0.789893583063378 0.960011061078552 GO:0005501 retinoid binding 3/2022 38/18639 0.0789473684210526 0.727744807121662 0.796136359986749 0.960011061078552 GO:0019840 isoprenoid binding 3/2022 38/18639 0.0789473684210526 0.727744807121662 0.796136359986749 0.960011061078552 GO:0005313 L-glutamate transmembrane transporter activity 1/2022 14/18639 0.0714285714285714 0.65843577787198 0.799754842615519 0.960011061078552 GO:0005344 oxygen carrier activity 1/2022 14/18639 0.0714285714285714 0.65843577787198 0.799754842615519 0.960011061078552 GO:0005347 ATP transmembrane transporter activity 1/2022 14/18639 0.0714285714285714 0.65843577787198 0.799754842615519 0.960011061078552 GO:0008191 metalloendopeptidase inhibitor activity 1/2022 14/18639 0.0714285714285714 0.65843577787198 0.799754842615519 0.960011061078552 GO:0008392 arachidonate epoxygenase activity 1/2022 14/18639 0.0714285714285714 0.65843577787198 0.799754842615519 0.960011061078552 GO:0008494 translation activator activity 1/2022 14/18639 0.0714285714285714 0.65843577787198 0.799754842615519 0.960011061078552 GO:0008559 ABC-type xenobiotic transporter activity 1/2022 14/18639 0.0714285714285714 0.65843577787198 0.799754842615519 0.960011061078552 GO:0015386 potassium:proton antiporter activity 1/2022 14/18639 0.0714285714285714 0.65843577787198 0.799754842615519 0.960011061078552 GO:0016530 metallochaperone activity 1/2022 14/18639 0.0714285714285714 0.65843577787198 0.799754842615519 0.960011061078552 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/2022 14/18639 0.0714285714285714 0.65843577787198 0.799754842615519 0.960011061078552 GO:0019763 immunoglobulin receptor activity 1/2022 14/18639 0.0714285714285714 0.65843577787198 0.799754842615519 0.960011061078552 GO:0019992 diacylglycerol binding 1/2022 14/18639 0.0714285714285714 0.65843577787198 0.799754842615519 0.960011061078552 GO:0034236 protein kinase A catalytic subunit binding 1/2022 14/18639 0.0714285714285714 0.65843577787198 0.799754842615519 0.960011061078552 GO:0043176 amine binding 1/2022 14/18639 0.0714285714285714 0.65843577787198 0.799754842615519 0.960011061078552 GO:0061783 peptidoglycan muralytic activity 1/2022 14/18639 0.0714285714285714 0.65843577787198 0.799754842615519 0.960011061078552 GO:0003743 translation initiation factor activity 4/2022 51/18639 0.0784313725490196 0.722988305114331 0.818355255159931 0.97678612055911 GO:0004129 cytochrome-c oxidase activity 1/2022 15/18639 0.0666666666666667 0.614540059347181 0.821494209500428 0.97678612055911 GO:0008020 G protein-coupled photoreceptor activity 1/2022 15/18639 0.0666666666666667 0.614540059347181 0.821494209500428 0.97678612055911 GO:0008242 omega peptidase activity 1/2022 15/18639 0.0666666666666667 0.614540059347181 0.821494209500428 0.97678612055911 GO:0008252 nucleotidase activity 1/2022 15/18639 0.0666666666666667 0.614540059347181 0.821494209500428 0.97678612055911 GO:0034483 heparan sulfate sulfotransferase activity 1/2022 15/18639 0.0666666666666667 0.614540059347181 0.821494209500428 0.97678612055911 GO:0047372 monoacylglycerol lipase activity 1/2022 15/18639 0.0666666666666667 0.614540059347181 0.821494209500428 0.97678612055911 GO:0050700 CARD domain binding 1/2022 15/18639 0.0666666666666667 0.614540059347181 0.821494209500428 0.97678612055911 GO:0050780 dopamine receptor binding 1/2022 15/18639 0.0666666666666667 0.614540059347181 0.821494209500428 0.97678612055911 GO:0051371 muscle alpha-actinin binding 1/2022 15/18639 0.0666666666666667 0.614540059347181 0.821494209500428 0.97678612055911 GO:0051393 alpha-actinin binding 2/2022 28/18639 0.0714285714285714 0.65843577787198 0.823287295699556 0.977037146753699 GO:0051959 dynein light intermediate chain binding 2/2022 28/18639 0.0714285714285714 0.65843577787198 0.823287295699556 0.977037146753699 GO:0071855 neuropeptide receptor binding 3/2022 40/18639 0.075 0.691357566765579 0.824035304217547 0.977037146753699 GO:0008137 NADH dehydrogenase (ubiquinone) activity 3/2022 41/18639 0.0731707317073171 0.674495187088369 0.836717633576854 0.983285265276695 GO:0140828 metal cation:monoatomic cation antiporter activity 3/2022 41/18639 0.0731707317073171 0.674495187088369 0.836717633576854 0.983285265276695 GO:0004536 DNA nuclease activity 5/2022 64/18639 0.078125 0.720164132047478 0.837737296593883 0.983285265276695 GO:0003688 DNA replication origin binding 1/2022 16/18639 0.0625 0.576131305637982 0.840874509564331 0.983285265276695 GO:0005149 interleukin-1 receptor binding 1/2022 16/18639 0.0625 0.576131305637982 0.840874509564331 0.983285265276695 GO:0008296 3'-5'-DNA exonuclease activity 1/2022 16/18639 0.0625 0.576131305637982 0.840874509564331 0.983285265276695 GO:0008391 arachidonate monooxygenase activity 1/2022 16/18639 0.0625 0.576131305637982 0.840874509564331 0.983285265276695 GO:0015385 sodium:proton antiporter activity 1/2022 16/18639 0.0625 0.576131305637982 0.840874509564331 0.983285265276695 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/2022 16/18639 0.0625 0.576131305637982 0.840874509564331 0.983285265276695 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/2022 16/18639 0.0625 0.576131305637982 0.840874509564331 0.983285265276695 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/2022 16/18639 0.0625 0.576131305637982 0.840874509564331 0.983285265276695 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/2022 16/18639 0.0625 0.576131305637982 0.840874509564331 0.983285265276695 GO:0004864 protein phosphatase inhibitor activity 4/2022 53/18639 0.0754716981132075 0.695705727562846 0.841029368392468 0.983285265276695 GO:0005246 calcium channel regulator activity 4/2022 53/18639 0.0754716981132075 0.695705727562846 0.841029368392468 0.983285265276695 GO:0140296 general transcription initiation factor binding 4/2022 53/18639 0.0754716981132075 0.695705727562846 0.841029368392468 0.983285265276695 GO:0004520 DNA endonuclease activity 3/2022 42/18639 0.0714285714285714 0.65843577787198 0.84860293951872 0.985526378473659 GO:0031492 nucleosomal DNA binding 3/2022 42/18639 0.0714285714285714 0.65843577787198 0.84860293951872 0.985526378473659 GO:0042056 chemoattractant activity 3/2022 42/18639 0.0714285714285714 0.65843577787198 0.84860293951872 0.985526378473659 GO:0051879 Hsp90 protein binding 3/2022 42/18639 0.0714285714285714 0.65843577787198 0.84860293951872 0.985526378473659 GO:0017069 snRNA binding 4/2022 54/18639 0.0740740740740741 0.682822288163534 0.851444631283347 0.985526378473659 GO:0016769 transferase activity, transferring nitrogenous groups 2/2022 30/18639 0.0666666666666667 0.614540059347181 0.851830487976373 0.985526378473659 GO:0008017 microtubule binding 25/2022 276/18639 0.0905797101449275 0.834972906721713 0.85664758020748 0.985526378473659 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/2022 17/18639 0.0588235294117647 0.542241228835748 0.8581516261224 0.985526378473659 GO:0004549 tRNA-specific ribonuclease activity 1/2022 17/18639 0.0588235294117647 0.542241228835748 0.8581516261224 0.985526378473659 GO:0004550 nucleoside diphosphate kinase activity 1/2022 17/18639 0.0588235294117647 0.542241228835748 0.8581516261224 0.985526378473659 GO:0004659 prenyltransferase activity 1/2022 17/18639 0.0588235294117647 0.542241228835748 0.8581516261224 0.985526378473659 GO:0005092 GDP-dissociation inhibitor activity 1/2022 17/18639 0.0588235294117647 0.542241228835748 0.8581516261224 0.985526378473659 GO:0008569 minus-end-directed microtubule motor activity 1/2022 17/18639 0.0588235294117647 0.542241228835748 0.8581516261224 0.985526378473659 GO:0009881 photoreceptor activity 1/2022 17/18639 0.0588235294117647 0.542241228835748 0.8581516261224 0.985526378473659 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/2022 17/18639 0.0588235294117647 0.542241228835748 0.8581516261224 0.985526378473659 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/2022 17/18639 0.0588235294117647 0.542241228835748 0.8581516261224 0.985526378473659 GO:0030548 acetylcholine receptor regulator activity 1/2022 17/18639 0.0588235294117647 0.542241228835748 0.8581516261224 0.985526378473659 GO:0031489 myosin V binding 1/2022 17/18639 0.0588235294117647 0.542241228835748 0.8581516261224 0.985526378473659 GO:0048038 quinone binding 1/2022 17/18639 0.0588235294117647 0.542241228835748 0.8581516261224 0.985526378473659 GO:0003774 cytoskeletal motor activity 13/2022 153/18639 0.0849673202614379 0.783237330540525 0.859236527398805 0.985526378473659 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/2022 43/18639 0.0697674418604651 0.643123317921468 0.859727654902893 0.985526378473659 GO:0005179 hormone activity 11/2022 132/18639 0.0833333333333333 0.768175074183976 0.86018121110022 0.985526378473659 GO:0047499 calcium-independent phospholipase A2 activity 2/2022 31/18639 0.0645161290322581 0.594716186465014 0.864466711224475 0.989535143512639 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 5/2022 67/18639 0.0746268656716418 0.687917976881173 0.865451784297367 0.989762131496443 GO:0001223 transcription coactivator binding 3/2022 44/18639 0.0681818181818182 0.628506878877799 0.870128291150011 0.990920247137264 GO:0003954 NADH dehydrogenase activity 3/2022 44/18639 0.0681818181818182 0.628506878877799 0.870128291150011 0.990920247137264 GO:0019212 phosphatase inhibitor activity 4/2022 56/18639 0.0714285714285714 0.65843577787198 0.870543694647925 0.990920247137264 GO:0003746 translation elongation factor activity 1/2022 18/18639 0.0555555555555556 0.512116716122651 0.873553699582851 0.990920247137264 GO:0015280 ligand-gated sodium channel activity 1/2022 18/18639 0.0555555555555556 0.512116716122651 0.873553699582851 0.990920247137264 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/2022 18/18639 0.0555555555555556 0.512116716122651 0.873553699582851 0.990920247137264 GO:0022851 GABA-gated chloride ion channel activity 1/2022 18/18639 0.0555555555555556 0.512116716122651 0.873553699582851 0.990920247137264 GO:0032393 MHC class I receptor activity 1/2022 18/18639 0.0555555555555556 0.512116716122651 0.873553699582851 0.990920247137264 GO:0099602 neurotransmitter receptor regulator activity 1/2022 18/18639 0.0555555555555556 0.512116716122651 0.873553699582851 0.990920247137264 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/2022 32/18639 0.0625 0.576131305637982 0.876106686519018 0.991135082410903 GO:0043425 bHLH transcription factor binding 2/2022 32/18639 0.0625 0.576131305637982 0.876106686519018 0.991135082410903 GO:0047498 calcium-dependent phospholipase A2 activity 2/2022 32/18639 0.0625 0.576131305637982 0.876106686519018 0.991135082410903 GO:0004715 non-membrane spanning protein tyrosine kinase activity 3/2022 45/18639 0.0666666666666667 0.614540059347181 0.879841144890799 0.994465552805593 GO:0004890 GABA-A receptor activity 1/2022 19/18639 0.0526315789473684 0.485163204747774 0.887284134008686 0.995225404419027 GO:0008301 DNA binding, bending 1/2022 19/18639 0.0526315789473684 0.485163204747774 0.887284134008686 0.995225404419027 GO:0016918 retinal binding 1/2022 19/18639 0.0526315789473684 0.485163204747774 0.887284134008686 0.995225404419027 GO:0022821 solute:potassium antiporter activity 1/2022 19/18639 0.0526315789473684 0.485163204747774 0.887284134008686 0.995225404419027 GO:0034987 immunoglobulin receptor binding 1/2022 19/18639 0.0526315789473684 0.485163204747774 0.887284134008686 0.995225404419027 GO:0042834 peptidoglycan binding 1/2022 19/18639 0.0526315789473684 0.485163204747774 0.887284134008686 0.995225404419027 GO:0070003 threonine-type peptidase activity 1/2022 19/18639 0.0526315789473684 0.485163204747774 0.887284134008686 0.995225404419027 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 4/2022 58/18639 0.0689655172413793 0.635731095876394 0.887487419966531 0.995225404419027 GO:0015631 tubulin binding 35/2022 385/18639 0.0909090909090909 0.838009171837065 0.887633468806159 0.995225404419027 GO:0016782 transferase activity, transferring sulphur-containing groups 5/2022 70/18639 0.0714285714285714 0.65843577787198 0.889066936881682 0.995944974708064 GO:0009055 electron transfer activity 9/2022 116/18639 0.0775862068965517 0.715197482860943 0.894063756782184 0.996228662630289 GO:0001786 phosphatidylserine binding 4/2022 59/18639 0.0677966101694915 0.624955992556455 0.89520870861725 0.996228662630289 GO:0070888 E-box binding 4/2022 59/18639 0.0677966101694915 0.624955992556455 0.89520870861725 0.996228662630289 GO:0099095 ligand-gated monoatomic anion channel activity 3/2022 47/18639 0.0638297872340425 0.588389418523897 0.897346175437374 0.996228662630289 GO:0001614 purinergic nucleotide receptor activity 1/2022 20/18639 0.05 0.460905044510386 0.899524277995498 0.996228662630289 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/2022 20/18639 0.05 0.460905044510386 0.899524277995498 0.996228662630289 GO:0016004 phospholipase activator activity 1/2022 20/18639 0.05 0.460905044510386 0.899524277995498 0.996228662630289 GO:0016502 nucleotide receptor activity 1/2022 20/18639 0.05 0.460905044510386 0.899524277995498 0.996228662630289 GO:0016505 peptidase activator activity involved in apoptotic process 1/2022 20/18639 0.05 0.460905044510386 0.899524277995498 0.996228662630289 GO:0030627 pre-mRNA 5'-splice site binding 1/2022 20/18639 0.05 0.460905044510386 0.899524277995498 0.996228662630289 GO:0043024 ribosomal small subunit binding 1/2022 20/18639 0.05 0.460905044510386 0.899524277995498 0.996228662630289 GO:0140664 ATP-dependent DNA damage sensor activity 1/2022 20/18639 0.05 0.460905044510386 0.899524277995498 0.996228662630289 GO:0070851 growth factor receptor binding 11/2022 139/18639 0.079136690647482 0.729489998505647 0.899615072136732 0.996228662630289 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 3/2022 48/18639 0.0625 0.576131305637982 0.905207848911279 0.997672696369844 GO:0016879 ligase activity, forming carbon-nitrogen bonds 3/2022 48/18639 0.0625 0.576131305637982 0.905207848911279 0.997672696369844 GO:0004623 phospholipase A2 activity 2/2022 35/18639 0.0571428571428571 0.526748622297584 0.905707761352263 0.997672696369844 GO:0016229 steroid dehydrogenase activity 2/2022 35/18639 0.0571428571428571 0.526748622297584 0.905707761352263 0.997672696369844 GO:0034061 DNA polymerase activity 2/2022 35/18639 0.0571428571428571 0.526748622297584 0.905707761352263 0.997672696369844 GO:0004521 RNA endonuclease activity 5/2022 73/18639 0.0684931506849315 0.631376773301898 0.909024321509507 0.997672696369844 GO:0005248 voltage-gated sodium channel activity 1/2022 21/18639 0.0476190476190476 0.438957185247986 0.910435815129237 0.997672696369844 GO:0008373 sialyltransferase activity 1/2022 21/18639 0.0476190476190476 0.438957185247986 0.910435815129237 0.997672696369844 GO:0015125 bile acid transmembrane transporter activity 1/2022 21/18639 0.0476190476190476 0.438957185247986 0.910435815129237 0.997672696369844 GO:0035613 RNA stem-loop binding 1/2022 21/18639 0.0476190476190476 0.438957185247986 0.910435815129237 0.997672696369844 GO:0070182 DNA polymerase binding 1/2022 21/18639 0.0476190476190476 0.438957185247986 0.910435815129237 0.997672696369844 GO:1904047 S-adenosyl-L-methionine binding 1/2022 21/18639 0.0476190476190476 0.438957185247986 0.910435815129237 0.997672696369844 GO:0045505 dynein intermediate chain binding 2/2022 36/18639 0.0555555555555556 0.512116716122651 0.91400640852197 0.999999999971532 GO:0003697 single-stranded DNA binding 9/2022 121/18639 0.0743801652892562 0.68564386786669 0.918924301737627 0.999999999971532 GO:0032813 tumor necrosis factor receptor superfamily binding 3/2022 50/18639 0.06 0.553086053412463 0.919316189622378 0.999999999971532 GO:0034062 5'-3' RNA polymerase activity 1/2022 22/18639 0.0454545454545455 0.419004585918533 0.920162895471309 0.999999999971532 GO:0097747 RNA polymerase activity 1/2022 22/18639 0.0454545454545455 0.419004585918533 0.920162895471309 0.999999999971532 GO:0030280 structural constituent of skin epidermis 2/2022 37/18639 0.0540540540540541 0.498275723795012 0.921615308432966 0.999999999971532 GO:0042805 actinin binding 2/2022 37/18639 0.0540540540540541 0.498275723795012 0.921615308432966 0.999999999971532 GO:0140375 immune receptor activity 12/2022 156/18639 0.0769230769230769 0.709084683862132 0.925372585042198 0.999999999971532 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 13/2022 167/18639 0.0778443113772455 0.717576716004193 0.925410011867385 0.999999999971532 GO:0005272 sodium channel activity 3/2022 51/18639 0.0588235294117647 0.542241228835748 0.92562624802628 0.999999999971532 GO:0051536 iron-sulfur cluster binding 5/2022 76/18639 0.0657894736842105 0.606454005934718 0.925763933728612 0.999999999971532 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/2022 23/18639 0.0434782608695652 0.400786995226422 0.928834036114646 0.999999999971532 GO:0016917 GABA receptor activity 1/2022 23/18639 0.0434782608695652 0.400786995226422 0.928834036114646 0.999999999971532 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/2022 23/18639 0.0434782608695652 0.400786995226422 0.928834036114646 0.999999999971532 GO:0046982 protein heterodimerization activity 32/2022 369/18639 0.0867208672086721 0.799401703215845 0.929025394696336 0.999999999971532 GO:0051540 metal cluster binding 5/2022 77/18639 0.0649350649350649 0.598577979883618 0.930702421433038 0.999999999971532 GO:0001664 G protein-coupled receptor binding 25/2022 297/18639 0.0841750841750842 0.775934418367653 0.930931214750572 0.999999999971532 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 3/2022 52/18639 0.0576923076923077 0.531813512896599 0.931480495930796 0.999999999971532 GO:0005540 hyaluronic acid binding 1/2022 24/18639 0.0416666666666667 0.384087537091988 0.936563815818996 0.999999999971532 GO:0019957 C-C chemokine binding 1/2022 24/18639 0.0416666666666667 0.384087537091988 0.936563815818996 0.999999999971532 GO:0060229 lipase activator activity 1/2022 24/18639 0.0416666666666667 0.384087537091988 0.936563815818996 0.999999999971532 GO:0140612 DNA damage sensor activity 1/2022 24/18639 0.0416666666666667 0.384087537091988 0.936563815818996 0.999999999971532 GO:0016251 RNA polymerase II general transcription initiation factor activity 3/2022 53/18639 0.0566037735849057 0.521779295672135 0.936907563583096 0.999999999971532 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 2/2022 40/18639 0.05 0.460905044510386 0.940806910036236 0.999999999971532 GO:0001848 complement binding 1/2022 25/18639 0.04 0.368724035608309 0.943454386026571 0.999999999971532 GO:0008483 transaminase activity 1/2022 25/18639 0.04 0.368724035608309 0.943454386026571 0.999999999971532 GO:0017025 TBP-class protein binding 1/2022 25/18639 0.04 0.368724035608309 0.943454386026571 0.999999999971532 GO:0000049 tRNA binding 5/2022 80/18639 0.0625 0.576131305637982 0.943803189808732 0.999999999971532 GO:0001530 lipopolysaccharide binding 2/2022 41/18639 0.0487804878048781 0.449663458058913 0.946144821649537 0.999999999971532 GO:0140223 general transcription initiation factor activity 4/2022 68/18639 0.0588235294117647 0.542241228835748 0.946147774346793 0.999999999971532 GO:0046906 tetrapyrrole binding 11/2022 152/18639 0.0723684210526316 0.66709940652819 0.948502941563949 0.999999999971532 GO:0019865 immunoglobulin binding 1/2022 26/18639 0.0384615384615385 0.354542341931066 0.949596818145098 0.999999999971532 GO:0120014 phospholipid transfer activity 1/2022 26/18639 0.0384615384615385 0.354542341931066 0.949596818145098 0.999999999971532 GO:0015252 proton channel activity 1/2022 27/18639 0.037037037037037 0.341411144081767 0.955072304832393 0.999999999971532 GO:0005245 voltage-gated calcium channel activity 2/2022 43/18639 0.0465116279069767 0.428748878614312 0.955475294334282 0.999999999971532 GO:0008168 methyltransferase activity 15/2022 204/18639 0.0735294117647059 0.677801536044685 0.963907336374758 0.999999999971532 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/2022 29/18639 0.0344827586206897 0.317865547938197 0.964304129313902 0.999999999971532 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/2022 60/18639 0.05 0.460905044510386 0.965070635509423 0.999999999971532 GO:0003684 damaged DNA binding 4/2022 74/18639 0.0540540540540541 0.498275723795012 0.966225488300957 0.999999999971532 GO:0048019 receptor antagonist activity 1/2022 30/18639 0.0333333333333333 0.30727002967359 0.968182530739334 0.999999999971532 GO:0070566 adenylyltransferase activity 1/2022 30/18639 0.0333333333333333 0.30727002967359 0.968182530739334 0.999999999971532 GO:0019003 GDP binding 4/2022 75/18639 0.0533333333333333 0.491632047477745 0.968800724992261 0.999999999971532 GO:0005164 tumor necrosis factor receptor binding 1/2022 31/18639 0.032258064516129 0.297358093232507 0.971639724723163 0.999999999971532 GO:0008327 methyl-CpG binding 1/2022 31/18639 0.032258064516129 0.297358093232507 0.971639724723163 0.999999999971532 GO:0008188 neuropeptide receptor activity 2/2022 48/18639 0.0416666666666667 0.384087537091988 0.972508917947633 0.999999999971532 GO:0038187 pattern recognition receptor activity 2/2022 48/18639 0.0416666666666667 0.384087537091988 0.972508917947633 0.999999999971532 GO:0030515 snoRNA binding 1/2022 32/18639 0.03125 0.288065652818991 0.974721435632974 0.999999999971532 GO:0020037 heme binding 9/2022 142/18639 0.0633802816901408 0.584245831069503 0.976400151312611 0.999999999971532 GO:0019239 deaminase activity 1/2022 33/18639 0.0303030303030303 0.279336390612355 0.977468426397209 0.999999999971532 GO:0042923 neuropeptide binding 1/2022 33/18639 0.0303030303030303 0.279336390612355 0.977468426397209 0.999999999971532 GO:0016741 transferase activity, transferring one-carbon groups 15/2022 215/18639 0.0697674418604651 0.643123317921468 0.979526544013098 0.999999999971532 GO:0008175 tRNA methyltransferase activity 1/2022 34/18639 0.0294117647058824 0.271120614417874 0.979917036621053 0.999999999971532 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/2022 34/18639 0.0294117647058824 0.271120614417874 0.979917036621053 0.999999999971532 GO:0019825 oxygen binding 1/2022 34/18639 0.0294117647058824 0.271120614417874 0.979917036621053 0.999999999971532 GO:0051427 hormone receptor binding 1/2022 34/18639 0.0294117647058824 0.271120614417874 0.979917036621053 0.999999999971532 GO:0008173 RNA methyltransferase activity 3/2022 67/18639 0.0447761194029851 0.412750786128704 0.981059593245985 0.999999999971532 GO:0005216 monoatomic ion channel activity 36/2022 448/18639 0.0803571428571429 0.740740250105977 0.981345380980334 0.999999999971532 GO:0005126 cytokine receptor binding 20/2022 275/18639 0.0727272727272727 0.670407337469652 0.98262068404195 0.999999999971532 GO:0015079 potassium ion transmembrane transporter activity 10/2022 160/18639 0.0625 0.576131305637982 0.983649946316485 0.999999999971532 GO:0055106 ubiquitin-protein transferase regulator activity 1/2022 36/18639 0.0277777777777778 0.256058358061325 0.984045183902604 0.999999999971532 GO:0099094 ligand-gated monoatomic cation channel activity 8/2022 136/18639 0.0588235294117647 0.542241228835748 0.984328383910216 0.999999999971532 GO:0008083 growth factor activity 10/2022 162/18639 0.0617283950617284 0.569018573469612 0.985573563667902 0.999999999971532 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/2022 38/18639 0.0263157894736842 0.242581602373887 0.987325103488085 0.999999999971532 GO:0004519 endonuclease activity 7/2022 127/18639 0.0551181102362205 0.508084301035071 0.987891044109375 0.999999999971532 GO:0000217 DNA secondary structure binding 1/2022 39/18639 0.0256410256410256 0.236361561287377 0.988702913323421 0.999999999971532 GO:0003924 GTPase activity 24/2022 331/18639 0.0725075528700906 0.668381937658566 0.989793375725202 0.999999999971532 GO:0004532 RNA exonuclease activity 1/2022 40/18639 0.025 0.230452522255193 0.989931015971811 0.999999999971532 GO:0061791 GTPase motor activity 1/2022 40/18639 0.025 0.230452522255193 0.989931015971811 0.999999999971532 GO:1990606 membrane scission GTPase motor activity 1/2022 40/18639 0.025 0.230452522255193 0.989931015971811 0.999999999971532 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 7/2022 130/18639 0.0538461538461538 0.496359278703492 0.990236893237034 0.999999999971532 GO:0019001 guanyl nucleotide binding 30/2022 400/18639 0.075 0.691357566765579 0.990792894266868 0.999999999971532 GO:0032561 guanyl ribonucleotide binding 30/2022 400/18639 0.075 0.691357566765579 0.990792894266868 0.999999999971532 GO:0005525 GTP binding 28/2022 378/18639 0.0740740740740741 0.682822288163534 0.99084887684608 0.999999999971532 GO:0004812 aminoacyl-tRNA ligase activity 1/2022 41/18639 0.024390243902439 0.224831729029456 0.991025670829867 0.999999999971532 GO:0008227 G protein-coupled amine receptor activity 1/2022 41/18639 0.024390243902439 0.224831729029456 0.991025670829867 0.999999999971532 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/2022 41/18639 0.024390243902439 0.224831729029456 0.991025670829867 0.999999999971532 GO:0004540 RNA nuclease activity 6/2022 121/18639 0.0495867768595041 0.457095911911126 0.992921112685964 0.999999999971532 GO:0030547 signaling receptor inhibitor activity 1/2022 44/18639 0.0227272727272727 0.209502292959266 0.993646194259383 0.999999999971532 GO:0003730 mRNA 3'-UTR binding 17/2022 262/18639 0.0648854961832061 0.598121050127981 0.994394997981674 0.999999999971532 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/2022 46/18639 0.0217391304347826 0.200393497613211 0.994952910822773 0.999999999971532 GO:0004527 exonuclease activity 3/2022 84/18639 0.0357142857142857 0.32921788893599 0.99599176692862 0.999999999971532 GO:0005261 monoatomic cation channel activity 23/2022 341/18639 0.0674486803519062 0.621748740395242 0.996506660269115 0.999999999971532 GO:0005244 voltage-gated monoatomic ion channel activity 9/2022 173/18639 0.0520231213872832 0.4795543815715 0.997068418762949 0.999999999971532 GO:0003823 antigen binding 9/2022 174/18639 0.0517241379310345 0.476798321907296 0.997270932635419 0.999999999971532 GO:0022834 ligand-gated channel activity 10/2022 188/18639 0.0531914893617021 0.490324515436581 0.997436940845301 0.999999999971532 GO:0022832 voltage-gated channel activity 9/2022 175/18639 0.0514285714285714 0.474073760067825 0.997460064771436 0.999999999971532 GO:0016779 nucleotidyltransferase activity 6/2022 136/18639 0.0441176470588235 0.406680921626811 0.997834024282162 0.999999999971532 GO:0005267 potassium channel activity 5/2022 124/18639 0.0403225806451613 0.371697616540634 0.998247958297267 0.999999999971532 GO:0140101 catalytic activity, acting on a tRNA 6/2022 139/18639 0.0431654676258993 0.397903635548534 0.998302470577408 0.999999999971532 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/2022 56/18639 0.0178571428571429 0.164608944467995 0.998404469334579 0.999999999971532 GO:0008408 3'-5' exonuclease activity 1/2022 58/18639 0.0172413793103448 0.158932773969099 0.998732804089917 0.999999999971532 GO:0015276 ligand-gated monoatomic ion channel activity 9/2022 186/18639 0.0483870967741935 0.44603713984876 0.998864629127573 0.999999999971532 GO:0022836 gated channel activity 19/2022 318/18639 0.059748427672956 0.550767034320587 0.999130149075519 0.999999999971532 GO:0022824 transmitter-gated monoatomic ion channel activity 1/2022 63/18639 0.0158730158730159 0.146319061749329 0.999287737087569 0.999999999971532 GO:0022835 transmitter-gated channel activity 1/2022 63/18639 0.0158730158730159 0.146319061749329 0.999287737087569 0.999999999971532 GO:0019843 rRNA binding 1/2022 65/18639 0.0153846153846154 0.141816936772426 0.999434361486484 0.999999999971532 GO:0004518 nuclease activity 10/2022 209/18639 0.0478468899521531 0.441057458861613 0.999435327957516 0.999999999971532 GO:0004497 monooxygenase activity 3/2022 106/18639 0.0283018867924528 0.260889647836067 0.999514231863045 0.999999999971532 GO:0098960 postsynaptic neurotransmitter receptor activity 1/2022 69/18639 0.0144927536231884 0.133595665075474 0.999643300929403 0.999999999971532 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/2022 73/18639 0.0136986301369863 0.12627535466038 0.9997750845633 0.999999999971532 GO:0030594 neurotransmitter receptor activity 2/2022 97/18639 0.0206185567010309 0.190063935880571 0.999818448032254 0.999999999971532 GO:0005249 voltage-gated potassium channel activity 2/2022 98/18639 0.0204081632653061 0.188124507963423 0.99983669908769 0.999999999971532 GO:0140098 catalytic activity, acting on RNA 22/2022 387/18639 0.0568475452196382 0.524026407195271 0.999877153953139 0.999999999971532 GO:0008528 G protein-coupled peptide receptor activity 3/2022 122/18639 0.0245901639344262 0.226674612054288 0.999900477444773 0.999999999971532 GO:0005125 cytokine activity 10/2022 234/18639 0.0427350427350427 0.393935935478962 0.999916486664778 0.999999999971532 GO:0001653 peptide receptor activity 3/2022 128/18639 0.0234375 0.216049239614243 0.999945551057535 0.999999999971532 GO:0003735 structural constituent of ribosome 5/2022 175/18639 0.0285714285714286 0.263374311148792 0.999982220044023 0.999999999971532 GO:0022843 voltage-gated monoatomic cation channel activity 3/2022 143/18639 0.020979020979021 0.1933867319624 0.999988151580119 0.999999999971532 GO:0045182 translation regulator activity 8/2022 356/18639 0.0224719101123595 0.207148334611409 0.999999999915271 0.999999999971532 GO:0030371 translation repressor activity 6/2022 329/18639 0.0182370820668693 0.168111262435399 0.999999999971532 0.999999999971532