category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	107/1666	250/9376	2.40872028811525	PSAP/GAA/CTSC/CLTC/GNS/VPS13C/MANBA/MCOLN3/CTSD/VPS13A/GNPTAB/GLB1/HEXA/ASAH1/HGSNAT/TPP1/LGMN/CTSL/ATP6V1B1/SLC17A5/SLC11A2/SLC38A9/NAGLU/CTSO/ATP6V0A1/AP2A2/LIPA/GUSB/CTSF/CTSV/NPC1/SPG11/ABCA5/TLR3/FUCA1/SMPD1/ATP6AP1/CLN5/SCARB2/AP3D1/GM2A/CTSA/SLC29A3/SLC29A1/ENTPD4/LAMP2/PIKFYVE/GGA1/ACP2/AP2A1/AP1S3/IGF2R/VPS35/AP2B1/CTSB/BLOC1S6/SORT1/CLN8/PLA2G15/IDS/ATP6V1A/SUMF1/TPCN1/PPT1/ARSG/AP1B1/CTBS/LAMP1/AP3S2/SGSH/OSTM1/MTOR/AP4E1/NEU1/ATP6V1H/TCIRG1/DMXL2/ATP6V0B/OSBPL3/MFSD8/DMXL1/CLCN7/AP3M1/OSBP/RRAGC/STX17/GALC/AP3B1/PLEKHM1/CLN3/GGA3/AP1S1/RRAGB/SLC15A3/AP5M1/SLC15A4/AP3M2/AGA/VPS39/FUCA2/TFE3/AP1G2/RPTOR/WDR7/DNASE2/NCOA7/TMEM175	10.494227844214
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	79/1666	174/9376	2.55517379365539	RRBP1/HSP90B1/LMAN1/GANAB/HSPA5/SEC62/RPN2/CKAP4/SEL1L/EDEM3/SEC31A/MAN1A2/P4HB/CANX/TUSC3/UBXN4/STT3B/MBTPS1/ATF6/PDIA3/MOGS/PPP1R15A/UBE4B/PDIA4/SEC63/SEC24D/ERLEC1/BCL2/SEC61A1/UBE2G2/XBP1/DNAJC3/ERO1B/SIL1/STT3A/UGGT1/UGGT2/OS9/PRKCSH/HYOU1/ATF6B/DNAJB1/WFS1/TRAM1/HSPA4L/MAN1C1/UBQLN1/DNAJC10/MAN1B1/AMFR/SEC24A/DDIT3/MAGT1/UBXN2A/SEC24B/MAN1A1/NPLOC4/HSPA1A/HSPA1B/NFE2L2/SSR1/DNAJC1/HSPH1/ERP29/RPN1/SEC23A/ERN1/DDOST/SVIP/MAP2K7/SYVN1/CUL1/MBTPS2/MAPK8/EDEM2/SAR1B/SEC61A2/DERL1/BCAP29	9.62516951097083
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	38/1666	77/9376	2.77738108230305	CDK6/GADD45B/PIK3R1/KRAS/TGFBR1/PIK3CA/NFKBIA/POLK/CDKN1A/CTBP1/CBL/PTPN11/BRAF/NFKB1/TGFBR2/MDM2/PIK3R3/SOS1/PIK3CB/SOS2/IKBKB/AKT3/SMAD4/CCND1/SHC1/CRK/MAPK1/BCR/AKT2/STAT5B/CRKL/HDAC2/E2F3/BCL2L1/RB1/HRAS/ABL1/GADD45A	7.27953669939939
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	63/1666	169/9376	2.09795634230023	IGF1R/BIRC6/RB1CC1/CTSD/CTSL/C9orf72/CFLAR/EIF2AK4/PIK3R1/UVRAG/BCL2/KRAS/WDFY3/ATG9A/IRS2/PIK3CA/NBR1/LAMP2/MTMR3/CTSB/SUPT20H/PDPK1/ATG12/PIK3R3/ATG2A/PTEN/PIK3CB/ULK2/TSC1/RPS6KB1/DAPK1/LAMP1/AKT3/TSC2/MTOR/MTMR4/ERN1/VMP1/ATG9B/ATG14/PIK3R4/MAPK1/EPG5/MAPK8/AKT2/RRAGC/PRKAA1/STX17/MAP3K7/ATG13/PLEKHM1/CAMKK2/BCL2L1/RRAGB/WIPI1/MRAS/ATG4B/HRAS/VPS39/WIPI2/ATG4D/TBK1/RPTOR	6.69522690652997
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	48/1666	122/9376	2.21423651427784	ITGAV/SLC2A1/NCOA3/SLC9A1/NCOR1/ATP2A2/NOTCH3/MED13/SLC16A2/EP300/SIN3A/PIK3R1/ATP1A1/NCOA2/KRAS/MED16/CREBBP/RXRA/MED13L/PIK3CA/MED12L/NCOA1/MED1/MED12/GSK3B/PDPK1/MDM2/PIK3R3/PIK3CB/THRB/AKT3/TSC2/MTOR/NOTCH2/PLCG2/RCAN1/MED24/CCND1/MAPK1/BMP4/MED14/AKT2/MED17/HDAC2/HRAS/KAT2B/PLCB1/WNT4	6.27500973934642
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	44/1666	108/9376	2.29282824240807	RANBP2/PNN/TPR/TNPO1/UPF2/THOC2/KPNB1/IPO7/RANBP17/XPO1/UPF3A/DDX39B/KPNA6/UPF1/POM121/POM121C/IPO9/AHCTF1/IPO8/NUP58/NUP210/TMEM33/NUP153/XPO6/NUP214/NUP160/IPO5/NUP98/SRRM1/NUP133/XPO4/NUP155/NCBP1/CASC3/DDX19A/KPNA3/TNPO3/NDC1/XPOT/TNPO2/NUP107/NXF1/KPNA5/NUP205	6.28138833662517
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	39/1666	93/9376	2.36006660728808	ITGA6/LAMC1/LAMB1/LAMA5/ITGAV/ITGB1/COL4A2/CDK6/COL4A1/GADD45B/PIK3R1/SKP2/BCL2/XIAP/RXRA/PIK3CA/NFKBIA/LAMB2/POLK/CDKN1A/BIRC2/NFKB1/LAMB4/TRAF4/PIK3R3/PTEN/PIK3CB/FN1/IKBKB/AKT3/PTK2/CCND1/ITGA3/AKT2/TRAF5/E2F3/BCL2L1/RB1/GADD45A	6.12707821859586
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	37/1666	87/9376	2.39345393329746	EGFR/JUN/FOS/GADD45B/TCF7L2/PIK3R1/PMAIP1/BCL2/KRAS/TGFBR1/SMAD2/PIK3CA/APPL1/APC/POLK/CDKN1A/BRAF/TGFBR2/GSK3B/MSH6/PIK3R3/SOS1/PIK3CB/SOS2/RPS6KB1/AKT3/SMAD4/MTOR/MSH3/CCND1/MAPK1/MAPK8/AKT2/HRAS/MSH2/RAC3/GADD45A	6.06965083442924
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	67/1666	203/9376	1.85746811039687	EGFR/ITGA6/ITGB4/LAMC1/LAMB1/LAMA5/ITGAV/MET/ITGB1/COL4A2/JUN/IGF1R/ITGB8/ARHGAP5/ROCK1/ITGB5/COL4A1/FLT1/ACTN4/DIAPH1/TLN1/PPP1R12A/VCL/PIK3R1/ROCK2/BCL2/XIAP/PPP1R12B/PIK3CA/PDGFD/LAMB2/RAPGEF1/PAK6/PIP5K1A/BIRC2/BRAF/GSK3B/LAMB4/VAV3/PDPK1/PIK3R3/SOS1/PTEN/DOCK1/PIK3CB/ERBB2/ITGB6/SOS2/FN1/AKT3/FLNB/PXN/PTK2/CCND1/SHC1/CRK/BCAR1/MAPK1/ITGA3/MYLK3/MAPK8/AKT2/CRKL/ARHGAP35/HRAS/RAC3/PPP1CB	5.74124720939198
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	74/1666	232/9376	1.79509044997309	EGFR/ITGA6/ITGB4/ITGAV/ITGB1/IQGAP2/IQGAP1/MYH10/ITGB8/DIAPH2/ROCK1/ITGB5/WASF2/SLC9A1/GNA12/SCIN/ACTN4/DIAPH1/PPP1R12A/FGFR2/VCL/PIK3R1/ROCK2/NCKAP1/RDX/KRAS/CYFIP2/PPP1R12B/PIK3CA/PDGFD/APC/ABI2/LIMK2/PIKFYVE/ARHGEF12/PAK6/PIP5K1A/PFN2/CYFIP1/GNG12/BRAF/VAV3/ARHGEF7/WASL/PIK3R3/SOS1/DOCK1/PIK3CB/BAIAP2/ITGB6/ACTR2/SOS2/FN1/AKT3/ENAH/PXN/PTK2/CRK/BCAR1/MAPK1/TIAM1/PIP4K2B/ITGA3/MYLK3/AKT2/CRKL/GNA13/ARHGAP35/MRAS/HRAS/ARPC1B/RAC3/MYH9/PPP1CB	5.70017735547114
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	49/1666	133/9376	2.0734188412207	EGFR/IGF1R/GADD45B/MAPK14/EP300/PIK3R1/SKP2/HOMER1/ATM/KRAS/CREBBP/IRS2/CAT/TGFBR1/PIK3CA/INSR/STK4/CDKN1A/BRAF/TGFBR2/PDPK1/FOXO4/ATG12/MDM2/USP7/PIK3R3/SOS1/PTEN/PIK3CB/SETD7/SOS2/PRKAB2/IKBKB/AKT3/SMAD4/PLK2/FBXO25/CCND1/G6PC3/SGK3/MAPK1/FOXO3/MAPK8/CSNK1E/AKT2/PRKAA1/HRAS/RBL2/GADD45A	5.79541453488122
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	62/1666	184/9376	1.89634114515371	MET/ITGB1/SEMA6A/SEMA6D/NRP1/RASA1/EPHB4/ROCK1/PLXNB1/BMP7/SEMA3F/PLXNB2/PLXNA1/SEMA4B/BMPR2/NFATC3/SRGAP1/RYK/EFNA5/PIK3R1/ROCK2/CAMK2G/KRAS/PPP3CA/FZD3/PIK3CA/LIMK2/PARD3/SEMA7A/ARHGEF12/PAK6/NTN4/DPYSL2/PTPN11/LRIG2/PLXNA2/NFATC2/GSK3B/EPHA2/PDPK1/PARD6B/PIK3R3/PIK3CB/ROBO1/SEMA4G/SEMA3E/PLCG2/ENAH/PTK2/SEMA4C/MAPK1/SEMA4D/SEMA3B/LRRC4/NCK1/HRAS/ABL1/ABLIM1/RAC3/SEMA3C/WNT4/NCK2	5.70785831103282
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	36/1666	86/9376	2.35584466344677	EGFR/JUN/GAB1/ERBB3/PIK3R1/CAMK2G/KRAS/PIK3CA/PAK6/CDKN1A/CBL/BRAF/GSK3B/PIK3R3/SOS1/PIK3CB/ERBB2/SOS2/RPS6KB1/AKT3/MTOR/PLCG2/PTK2/SHC1/CRK/ABL2/MAPK1/MAP2K7/MAPK8/AKT2/STAT5B/CRKL/NCK1/HRAS/ABL1/NCK2	5.8714754917047
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	97/1666	333/9376	1.63934402589865	EGFR/ITGA6/ITGB4/LAMC1/LAMB1/LAMA5/ITGAV/ITGB1/COL4A2/CDK6/ITGB8/DLG1/MAML2/ITGB5/COL4A1/UBR4/CREB3L2/JAG1/TCF7L2/NOTCH3/ATP6V1B1/RBPJ/CHD4/FZD5/PRKCI/EP300/ATP6V0A1/DVL3/PIK3R1/ATM/KRAS/CREBBP/TLR3/ATP6AP1/FZD3/ATR/PIK3CA/FZD6/MAML3/UBE3A/APC/LAMB2/CSNK1A1/PARD3/CDKN1A/MAGI1/NFKB1/CREB1/PPP2R5E/PSEN1/GSK3B/ATP6V1A/LAMB4/MDM2/PARD6B/PIK3R3/SOS1/PTEN/PIK3CB/MAML1/ITGB6/PPP2R3A/TSC1/SOS2/FN1/RPS6KB1/FZD10/IKBKB/AKT3/TSC2/MTOR/NOTCH2/PPP2R2A/PXN/PTK2/ATP6V1H/TCIRG1/CCND1/HES1/NFX1/ATP6V0B/EIF2AK2/MAPK1/ITGA3/AKT2/TYK2/RBL1/SCRIB/JAK1/HDAC2/RB1/RFNG/HRAS/TBK1/RBL2/PPP2R3B/WNT4	5.52200010394629
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	27/1666	56/9376	2.71342822843423	GANAB/RPN2/MAN2A1/MAN1A2/FUT8/TUSC3/STT3B/MOGS/STT3A/B4GALT1/MAN2A2/MAN1C1/MAN1B1/ALG2/MGAT1/MAGT1/MAN1A1/ALG10B/MGAT3/RPN1/DDOST/ALG8/DPM3/ALG11/MGAT2/MGAT4A/ALG9	5.97789004574954
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	33/1666	77/9376	2.41193620305265	EGFR/CDK6/GADD45B/PIK3R1/KRAS/TGFBR1/SMAD2/PIK3CA/POLK/CDKN1A/BRAF/NFKB1/TGFBR2/PIK3R3/PIK3CB/ERBB2/RPS6KB1/IKBKB/AKT3/SMAD4/MTOR/RALBP1/CCND1/MAPK1/MAPK8/AKT2/BRCA2/JAK1/E2F3/BCL2L1/RB1/RAC3/GADD45A	5.78280117284376
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	39/1666	99/9376	2.21703226745244	EGFR/JUN/FOS/IGF1R/NCOA3/NCOR1/JAG1/NOTCH3/MAPK14/ADCY7/PIK3R1/BCL2/KRAS/PIK3CA/CDKN1A/MED1/BRAF/MDM2/PIK3R3/SOS1/PIK3CB/ERBB2/SP1/SOS2/RPS6KB1/AKT3/MTOR/NOTCH2/PTK2/CCND1/SHC1/MAPK1/MAPK8/AKT2/ADCY6/CARM1/E2F3/RB1/HRAS	5.65863732160333
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	49/1666	138/9376	1.99829497016198	PTPRF/PHKB/SORBS1/PRKCI/FLOT2/PIK3R1/KRAS/FASN/IRS2/PDE3B/PIK3CA/INSR/RAPGEF1/CBL/BRAF/INPPL1/PRKAR2A/GSK3B/PDPK1/PIK3R3/SOS1/PIK3CB/TSC1/SOS2/RPS6KB1/PRKAB2/IKBKB/AKT3/TSC2/MTOR/SOCS1/ACACA/SHC1/G6PC3/CRK/MAPK1/PHKA2/MAPK8/AKT2/PRKAA1/CRKL/RHOQ/MKNK1/PTPN1/HRAS/INPP5A/RPTOR/SOCS4/PPP1CB	5.49168217411796
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	37/1666	93/9376	2.23903755050407	EGFR/CDH1/MET/IQGAP1/PTPRF/IGF1R/CTNND1/ROCK1/LMO7/WASF2/ACTN4/SORBS1/TCF7L2/PTPRM/EP300/VCL/ROCK2/CREBBP/KRIT1/TJP1/TGFBR1/INSR/ARHGAP29/PARD3/TGFBR2/SMURF2/WASL/ERBB2/BAIAP2/YES1/SMAD4/MAPK1/MAP3K7/PTPN1/PTPN6/RAC3/FER	5.581844261917
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	54/1666	158/9376	1.92344279483945	CLIP1/LRP5/IGF1R/RICTOR/ATP6V1B1/FZD5/SLC38A9/DVL3/PIK3R1/SKP2/KRAS/SLC3A2/FZD3/PIK3CA/INSR/FZD6/LPIN2/BRAF/FNIP2/GSK3B/ATP6V1A/RPS6KA3/PDPK1/PIK3R3/SOS1/PTEN/PIK3CB/FNIP1/ULK2/TSC1/SOS2/RPS6KB1/LPIN1/FZD10/IKBKB/AKT3/SESN2/TSC2/MTOR/ATP6V1H/MAPK1/LRP6/NPRL3/AKT2/RRAGC/PRKAA1/MIOS/STRADB/RRAGB/HRAS/CAB39/RPTOR/PRR5/WNT4	5.44146871198477
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	36/1666	90/9376	2.25114045618247	IGF1R/RB1CC1/CREB3L2/ADCY7/PIK3R1/KRAS/IRS2/CAT/PIK3CA/INSR/APPL1/ATF6B/NFKB1/CREB1/EHMT1/PIK3R3/PIK3CB/TSC1/RPS6KB1/PRKAB2/AKT3/SESN2/TSC2/MTOR/ATF2/SESN1/FOXO3/SESN3/AKT2/PRKAA1/ADCY6/ADIPOR2/ATG13/CAMKK2/HRAS/RPTOR	5.54381756548426
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	31/1666	73/9376	2.3899093884129	EGFR/MET/CDK6/KIF5B/EML4/GADD45B/PIK3R1/KRAS/RXRA/PIK3CA/POLK/STK4/CDKN1A/BRAF/PDPK1/PIK3R3/SOS1/PIK3CB/ERBB2/SOS2/AKT3/PLCG2/CCND1/MAPK1/FOXO3/AKT2/STAT5B/E2F3/RB1/HRAS/GADD45A	5.54156403121631
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	40/1666	106/9376	2.1237174114929	EGFR/HSP90B1/SPINT1/IGF1R/SLC19A1/CREB3L2/TCF7L2/EP300/FGFR2/PIK3R1/BCL2/KRAS/CREBBP/PIK3CA/PDGFD/NFKBIA/FOLR1/CDKN1A/BRAF/NFKB1/CREB1/GSK3B/PDPK1/MDM2/PIK3R3/SOS1/PTEN/PIK3CB/ERBB2/SOS2/IKBKB/AKT3/MTOR/SLC46A1/CCND1/MAPK1/AKT2/E2F3/RB1/HRAS	5.40836661608864
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	22/1666	44/9376	2.81392557022809	RPN2/MAN2A1/MAN1A2/HEXA/FUT8/TUSC3/STT3B/STT3A/B4GALT1/MAN2A2/MAN1C1/MAN1B1/ALG2/MGAT1/MAGT1/MAN1A1/RPN1/DDOST/ALG11/MGAT2/MGAT4A/ALG9	5.60601665688466
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	56/1666	170/9376	1.85388037567968	EGFR/MET/CDK6/LRP5/IGF1R/SMARCA2/ARID1A/GAB1/PBRM1/GADD45B/TCF7L2/FZD5/DVL3/BRD7/PIK3R1/KRAS/FZD3/TGFBR1/SMAD2/PIK3CA/FZD6/APC/CSNK1A1/ARID1B/POLK/CDKN1A/SMARCC1/BRAF/TGFBR2/GSK3B/ARID2/PIK3R3/SOS1/PTEN/SMARCA4/PIK3CB/SMARCD1/SOS2/NFE2L2/RPS6KB1/FZD10/AKT3/SMAD4/MTOR/PLCG2/CCND1/SHC1/MAPK1/LRP6/AKT2/E2F3/BCL2L1/RB1/HRAS/GADD45A/WNT4	5.22254217222547
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	49/1666	142/9376	1.94200497100249	DDB1/BIRC6/UBR5/HUWE1/HERC2/HERC4/UBE4A/UBE4B/FBXW11/TRIP12/SKP2/WWP1/RHOBTB1/XIAP/CUL5/UBE2G2/MAP3K1/UBE2H/SIAH1/UBA1/PPIL2/UBA6/PIAS1/KLHL9/UBE3A/UBE3C/BIRC2/CBL/NEDD4/HERC1/SMURF2/MGRN1/MDM2/FBXW7/TRIM37/ITCH/ANAPC5/ANAPC1/ANAPC4/SOCS1/UBE2R2/UBE2E2/SYVN1/CUL1/UBA3/WWP2/VHL/FBXW8/UBE2Q1	5.25773120274941
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	33/1666	83/9376	2.23757936909704	JARID2/MTF2/KDM2A/EP300/PHC3/YY1/SUZ12/CREBBP/TEX10/MGA/OGT/SFMBT2/HCFC1/CBX4/AEBP2/DCAF7/BMI1/USP16/LCOR/USP7/YAF2/MBD6/EZH1/FOXK2/ASXL2/FOXK1/RBBP4/FBRS/PHC1/HDAC2/RYBP/MBD5/PCGF3	5.26417218640701
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	27/1666	62/9376	2.45083839987608	TLE4/MAML2/JAG1/NOTCH3/RBPJ/SPEN/NCSTN/EP300/DVL3/CREBBP/ADAM17/TLE1/DTX4/MAML3/CTBP1/PSEN1/MAML1/ITCH/NOTCH2/ATXN1/HES1/NUMB/TLE3/HDAC2/RFNG/KAT2B/PSEN2	5.32773625541646
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	26/1666	59/9376	2.48006999409933	EGFR/CDH1/GADD45B/TCF7L2/PIK3R1/KRAS/PIK3CA/APC/POLK/CDKN1A/BRAF/GSK3B/PDPK1/PIK3R3/SOS1/PTEN/PIK3CB/ERBB2/SOS2/AKT3/CCND1/MAPK1/FOXO3/AKT2/HRAS/GADD45A	5.30110199059946
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	37/1666	99/9376	2.10333830501898	EGFR/JUN/FOS/PLPP3/WASF2/SLC44A2/PIK3R1/KRAS/SLC22A5/SLC44A1/LYPLA1/SLC44A5/PIK3CA/PDGFD/GPCPD1/CHPT1/PIP5K1A/DGKH/DGKA/PDPK1/PIK3R3/SOS1/PIK3CB/SP1/TSC1/SOS2/RPS6KB1/AKT3/TSC2/MTOR/DGKD/MAPK1/DGKZ/MAPK8/AKT2/HRAS/RAC3	5.13001296523056
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	49/1666	148/9376	1.86327503974563	EGFR/JUN/CDK6/FOS/LRP5/IGF1R/NCOA3/GADD45B/JAG1/TCF7L2/NOTCH3/FZD5/DVL3/PIK3R1/KRAS/FZD3/PIK3CA/FZD6/APC/CSNK1A1/NCOA1/POLK/CDKN1A/BRAF/GSK3B/PIK3R3/SOS1/PTEN/PIK3CB/ERBB2/SP1/SOS2/RPS6KB1/FZD10/AKT3/MTOR/NOTCH2/CCND1/SHC1/HES1/MAPK1/LRP6/AKT2/BRCA2/E2F3/RB1/HRAS/GADD45A/WNT4	4.92064684278231
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	48/1666	144/9376	1.87595038015206	IL6ST/IGF1R/ZFHX3/RIF1/LIFR/JARID2/SMAD5/TBX3/BMPR2/MAPK14/FZD5/DVL3/FGFR2/REST/PIK3R1/KRAS/FZD3/KAT6A/SMAD2/PIK3CA/FZD6/BMPR1A/APC/ACVR2B/SMARCAD1/ID2/BMI1/ISL1/GSK3B/PIK3R3/PIK3CB/FZD10/ID4/ID1/AKT3/SMAD4/ACVR2A/ID3/ACVR1/MAPK1/BMP4/AKT2/JAK1/HRAS/PCGF3/SETDB1/KLF4/WNT4	4.92389520502048
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	36/1666	98/9376	2.06737388833084	ITPR2/CDS1/SACM1L/PIK3R1/SYNJ1/PIK3C2A/PIK3CA/PPIP5K2/PIKFYVE/MTMR3/PIP5K1A/IP6K1/INPPL1/DGKH/PI4KA/DGKA/PIK3R3/PTEN/PIK3CB/INPP5F/PI4KB/PLCG2/DGKD/MTMR4/INPP1/SYNJ2/PIP4K2B/IP6K2/DGKZ/CDIPT/INPP4A/IMPA1/PI4K2A/MTMR1/INPP5A/PLCB1	4.93740071628222
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	62/1666	204/9376	1.71042534660923	EGFR/ITGAV/MET/ITGB1/IQGAP1/IGF1R/ANK3/ROCK1/ITGB5/SLC9A1/GAB1/ERBB3/ITPR2/GPC1/CTSL/PPP1R12A/MAPK14/FZD5/PIK3R1/ROCK2/DDX5/RDX/CAMK2G/KRAS/PPP1R12B/FZD3/SMAD2/PIK3CA/GPC3/FZD6/ARHGEF12/CDKN1A/CBL/PTPN11/BRAF/VAV3/PDPK1/MDM2/PIK3R3/SOS1/PIK3CB/ERBB2/SOS2/FN1/RPS6KB1/FZD10/AKT3/MTOR/PLCG2/PXN/PTK2/CCND1/MAPK1/TIAM1/FRS2/AKT2/MRAS/HRAS/PTPN6/PPP1CB/HSPG2/WNT4	4.76867204966964
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	46/1666	138/9376	1.87595038015206	ITGB1/JUN/FOS/ROCK1/PKN2/GNAQ/WASF2/MAPK14/NFATC3/PIK3R1/ROCK2/WIPF2/TAB2/PIK3CA/NFKBIA/ARHGEF12/PIP5K1A/NFKB1/NFATC2/GSK3B/VAV3/ARHGEF7/RPS6KA3/WASL/GIT2/PIK3R3/DOCK1/PIK3CB/BAIAP2/ACTR2/FN1/IKBKB/AKT3/PXN/PTK2/CRK/BCAR1/MAPK1/MAP2K7/MAPK8/AKT2/CRKL/MAP3K7/ARPC1B/TBK1/RAC3	4.81865704212895
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	31/1666	80/9376	2.18079231692677	EGFR/MET/IGF1R/NF1/GAB1/ERBB3/FGFR2/PIK3R1/BCL2/KRAS/PIK3CA/PDGFD/BRAF/GSK3B/PIK3R3/SOS1/PTEN/PIK3CB/ERBB2/SOS2/RPS6KB1/AKT3/MTOR/PLCG2/SHC1/MAPK1/FOXO3/AKT2/JAK1/BCL2L1/HRAS	4.93022117174042
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	28/1666	70/9376	2.25114045618247	MET/SLC2A1/JUN/GAB1/EPAS1/EP300/PIK3R1/KRAS/CREBBP/PIK3CA/RAPGEF1/PAK6/CDKN1A/PTPN11/BRAF/ARNT/PIK3R3/SOS1/PIK3CB/SOS2/AKT3/CRK/MAPK1/AKT2/CRKL/HRAS/TFE3/VHL	4.88393090354302
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	41/1666	120/9376	1.92284913965586	JUN/MAGED1/KIDINS220/RPS6KA5/GAB1/MAPK14/PIK3R1/CAMK2G/BCL2/KRAS/MAP3K1/PIK3CA/NFKBIA/RAPGEF1/PTPN11/BRAF/NFKB1/SORT1/PSEN1/GSK3B/RPS6KA3/PDPK1/PIK3R3/SOS1/PIK3CB/SOS2/IKBKB/AKT3/PLCG2/SHC1/CRK/MAPK1/MAP2K7/FOXO3/FRS2/MAPK8/AKT2/CRKL/HRAS/ABL1/PSEN2	4.7293952346444
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	30/1666	78/9376	2.16455813094469	SACM1L/SYNJ1/ISYNA1/PIK3C2A/PIK3CA/PPIP5K2/PIKFYVE/MTMR3/PIP5K1A/IP6K1/INPPL1/PI4KA/PTEN/PIK3CB/INPP5F/PI4KB/PLCG2/MINPP1/MTMR4/INPP1/SYNJ2/PIP4K2B/IP6K2/CDIPT/INPP4A/IMPA1/PI4K2A/MTMR1/INPP5A/PLCB1	4.80075618501641
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	48/1666	150/9376	1.80091236494598	EGFR/CDH1/MET/LRP5/GAB1/GADD45B/TCF7L2/FZD5/ABCB1/DVL3/FGFR2/PIK3R1/BCL2/KRAS/RXRA/FZD3/TGFBR1/SMAD2/PIK3CA/FZD6/APC/CSNK1A1/POLK/CDKN1A/BRAF/TGFBR2/GSK3B/PIK3R3/SOS1/PIK3CB/ERBB2/SOS2/RPS6KB1/FZD10/AKT3/SMAD4/MTOR/CCND1/SHC1/JUP/MAPK1/LRP6/AKT2/E2F3/RB1/HRAS/GADD45A/WNT4	4.59642153480057
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	38/1666	110/9376	1.94416675761214	FBN1/LTBP1/ROCK1/BMP7/TFRC/NCOR1/ZFYVE16/SMAD5/BMPR2/EP300/SIN3A/CREBBP/TGFBR1/SMAD2/BMPR1A/ACVR2B/LEMD3/ID2/TGFBR2/SMURF2/SP1/RPS6KB1/ID4/ID1/SMAD4/ACVR2A/ZFYVE9/ID3/ACVR1/MAPK1/SKI/BMP4/CUL1/SMAD7/RBL1/HDAC2/E2F4/RGMB	4.63014773125392
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	23/1666	55/9376	2.35346502237259	PSAP/PLPP3/B4GALT5/GLB1/HEXA/ASAH1/DEGS1/SPTLC3/SGPP1/SMPD1/GM2A/SGMS1/KDSR/CERS6/NEU1/GBA2/SAMD8/ACER3/UGCG/SGPL1/GALC/SMPD4/CERS2	4.67943129542019
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	41/1666	125/9376	1.84593517406963	ORMDL1/ROCK1/GNAQ/GNA12/CTSD/ASAH1/DEGS1/MAPK14/SPTLC3/SGPP1/PIK3R1/ROCK2/BCL2/KRAS/SMPD1/PIK3CA/SGMS1/NFKB1/PPP2R5E/PDPK1/S1PR3/PIK3R3/PTEN/PIK3CB/S1PR2/PPP2R3A/AKT3/PPP2R2A/CERS6/ORMDL3/NSMAF/MAPK1/SGPL1/MAPK8/AKT2/GNA13/HRAS/CERS2/RAC3/PLCB1/PPP2R3B	4.42581949118986
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	37/1666	109/9376	1.91037148804476	SLC2A1/PTPRF/SLC27A2/CREB3L2/PIK3R1/IRS2/GFPT1/PIK3CA/INSR/NFKBIA/SLC27A6/OGT/CPT1A/PTPN11/NFKB1/CREB1/GSK3B/RPS6KA3/PDPK1/PIK3R3/PTEN/PIK3CB/SLC27A3/RPS6KB1/PRKAB2/IKBKB/AKT3/MTOR/PPARA/G6PC3/MAPK8/PPARGC1B/AKT2/PRKAA1/MLXIP/PTPN1/PPP1CB	4.44383845417986
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	70/1666	250/9376	1.57579831932773	EGFR/IGF1R/CLTC/EEA1/TFRC/KIF5B/ZFYVE16/ARFGEF1/PRKCI/AP2A2/FGFR2/CYTH3/IST1/USP8/WWP1/EPN2/VPS36/WIPF2/LDLR/TGFBR1/SMAD2/RAB11FIP4/RAB5B/RAB11FIP2/DNAJC6/ASAP1/EPN3/FOLR1/IQSEC1/PARD3/RAB11FIP1/PIP5K1A/AP2A1/DAB2/PSD3/IGF2R/VPS35/SH3KBP1/GBF1/AP2B1/CBL/NEDD4/HGS/TGFBR2/ARFGEF2/SMURF2/RABEP1/EHD3/MDM2/WASL/GIT2/PARD6B/HSPA1A/MVB12B/AGAP1/HSPA1B/ACTR2/CHMP4C/ITCH/PSD4/ZFYVE9/EPS15/RAB31/ZFYVE27/SH3GLB2/ACAP2/EHD1/RUFY2/HRAS/ARPC1B	4.28939570638622
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	40/1666	122/9376	1.84519709523154	FOS/GNAQ/CREB3L2/ITPR2/MAPK14/EP300/ADCY7/PIK3R1/KRAS/CREBBP/MAP3K1/IRS2/PIK3CA/ATF6B/JUNB/GHR/CREB1/GSK3B/PIK3R3/SOS1/PIK3CB/SOS2/AKT3/MTOR/SOCS1/PLCG2/ATF2/PTK2/SHC1/CRK/BCAR1/GNA11/MAPK1/MAPK8/AKT2/STAT5B/CRKL/ADCY6/HRAS/PLCB1	4.36786403792137
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	11/1666	18/9376	3.43924236361211	MANBA/GLB1/HEXA/FUCA1/MAN2B2/NEU1/GBA2/MAN2C1/AGA/FUCA2/ENGASE	4.81499270942381
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	48/1666	157/9376	1.72061690918406	ZFP36L1/CDK6/GADD45B/ITPR2/RAD50/TRPM7/MAPK14/NFATC3/FBXW11/PIK3R1/ATM/HIPK2/KRAS/PPP3CA/ATR/TGFBR1/SMAD2/PIK3CA/HIPK1/CDKN1A/NFKB1/TGFBR2/NFATC2/MDM2/PIK3R3/PTEN/PIK3CB/TRPV4/TSC1/HIPK3/AKT3/TSC2/MTOR/CCND1/RAD9A/MAPK1/RBBP4/FOXO3/AKT2/RBL1/E2F3/RB1/MRAS/E2F4/HRAS/RBL2/GADD45A/PPP1CB	4.23261059765867
Human Diseases	Cancer: specific types	hsa05214	Glioma	28/1666	76/9376	2.0734188412207	EGFR/CDK6/IGF1R/GADD45B/PIK3R1/CAMK2G/KRAS/PIK3CA/POLK/CDKN1A/BRAF/MDM2/PIK3R3/SOS1/PTEN/PIK3CB/SOS2/AKT3/MTOR/PLCG2/CCND1/SHC1/MAPK1/AKT2/E2F3/RB1/HRAS/GADD45A	4.36747556171802
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	48/1666	158/9376	1.70972692874618	ATRX/CDK6/PRKDC/NIPBL/TFDP2/GADD45B/PDS5A/EP300/PDS5B/SKP2/STAG1/ATM/CREBBP/STAG2/WAPL/ATR/SMAD2/SMC3/MCM6/MAU2/ESCO1/SMC1A/CDKN1A/PPP2R5E/GSK3B/MDM2/MCM2/CDC14B/ANAPC5/ANAPC1/SMAD4/ANAPC4/CCND1/RAD21/CUL1/YWHAG/RBL1/ORC4/HDAC2/E2F3/RB1/MCM3/E2F4/WEE1/ORC2/ABL1/RBL2/GADD45A	4.18212898341669
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	24/1666	62/9376	2.17852302211207	IGF1R/ADCY7/PIK3R1/KRAS/IRS2/CAT/PIK3CA/INSR/HSPA1A/PIK3R3/PIK3CB/HSPA1B/RPS6KB1/EIF4EBP2/PRKAB2/AKT3/MTOR/FOXO3/AKT2/PRKAA1/ADCY6/HDAC2/HRAS/RPTOR	4.32774582840222
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	38/1666	117/9376	1.82784908835329	BPTF/SMARCA2/ARID1A/BAZ1B/PBRM1/RSF1/BAZ2B/CHD4/BAZ2A/BRD7/EPC1/YY1/BRD9/SMARCA5/BAZ1A/ARID1B/TRRAP/EP400/SMARCC1/INO80D/ARID2/SMARCA4/SMARCD1/DPF2/ING3/INO80/BRD8/RBBP4/DMAP1/CHD3/CECR2/NFRKB/HDAC2/ACTR6/PHF6/SS18/EPC2/MTA3	4.18849509701146
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	63/1666	227/9376	1.56191463369489	EGFR/ITGAV/CDK6/AKAP13/ROCK1/GNAQ/GNA12/CREB3L2/ITPR2/PDIA3/MAPK14/NFATC3/ADCY7/PIK3R1/ROCK2/IL10RB/KRAS/PPP3CA/PIK3CA/NFKBIA/ATF6B/ARHGEF12/TAPBP/CDKN1A/GNG12/NFKB1/CREB1/NFATC2/GNB4/GSK3B/MDM2/PIK3R3/SOS1/PIK3CB/SP1/TSC1/SOS2/RPS6KB1/IKBKB/AKT3/TSC2/MTOR/ATF2/PXN/PTK2/CCND1/CRK/BCAR1/GNA11/MAPK1/AKT2/CRKL/ADCY6/TRAF5/GNA13/JAK1/E2F3/RB1/HRAS/TBK1/RAC3/PLCB1/ARHGEF11	3.98375301247092
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	26/1666	71/9376	2.06090323453325	FOS/PRLR/MAPK14/PIK3R1/KRAS/SOCS7/PIK3CA/NFKB1/GSK3B/PIK3R3/SOS1/PIK3CB/SOS2/SOCS5/AKT3/SOCS1/CCND1/SHC1/MAPK1/FOXO3/MAPK8/AKT2/STAT5B/SOCS6/HRAS/SOCS4	4.17102417355075
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	48/1666	163/9376	1.65728131743495	JUN/FOS/DDB1/CREB3L2/MAPK14/NFATC3/EP300/PIK3R1/BCL2/KRAS/CREBBP/TLR3/ATP6AP1/MAP3K1/TAB2/TGFBR1/PIK3CA/MAVS/NFKBIA/ATF6B/CDKN1A/BRAF/NFKB1/CREB1/TGFBR2/NFATC2/PIK3R3/SOS1/PIK3CB/SOS2/IKBKB/AKT3/SMAD4/ATF2/DDX3X/MAPK1/MAP2K7/MAPK8/AKT2/STAT5B/TYK2/MAP3K7/JAK1/E2F3/RB1/HRAS/TBK1/HSPG2	3.93496163462
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	46/1666	157/9376	1.64892453796805	CDH1/DLG5/DLG1/TEAD1/FRMD6/BMP7/RASSF6/AMOT/LATS2/TCF7L2/BMPR2/FZD5/PRKCI/DVL3/FBXW11/FZD3/TGFBR1/SMAD2/FZD6/BMPR1A/APC/WWC1/PARD3/ID2/BIRC2/YAP1/TGFBR2/GSK3B/TEAD3/PARD6B/SAV1/FZD10/LATS1/ID1/SMAD4/PPP2R2A/CCND1/BMP4/YWHAG/CSNK1E/SMAD7/SCRIB/LIMD1/WWTR1/PPP1CB/WNT4	3.81151877159575
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	61/1666	224/9376	1.53258446235637	SLC2A1/JUN/FOS/NRP1/DLG1/CREB3L2/TLN1/CANX/EGR1/NFATC3/EP300/XPO1/ADCY7/PIK3R1/ATM/KRAS/XIAP/CREBBP/MAP3K1/PPP3CA/ATR/TGFBR1/SMAD2/PIK3CA/NFKBIA/ATF6B/TRRAP/CDKN1A/NFKB1/CREB1/TGFBR2/NFATC2/ELK4/LTBR/PIK3R3/PTEN/PIK3CB/GPS2/ANAPC5/IKBKB/ANAPC1/AKT3/SMAD4/ANAPC4/ATF2/CCND1/CRTC3/MAPK1/MAPK8/AKT2/STAT5B/ADCY6/JAK1/E2F3/BCL2L1/RB1/ZFP36/HRAS/KAT2B/ETS2/SRF	3.75016557896775
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	37/1666	119/9376	1.74983606888133	JUN/FOS/RPS6KA5/CREB3L2/JAG1/MMP14/MAPK14/CFLAR/PIK3R1/XIAP/ADAM17/TAB3/TAB2/PIK3CA/NFKBIA/ATF6B/JUNB/BIRC2/NFKB1/CREB1/CYLD/PIK3R3/PIK3CB/DNM1L/ITCH/IKBKB/AKT3/BAG4/RHBDF1/ATF2/EDN1/MAPK1/MAP2K7/MAPK8/AKT2/TRAF5/MAP3K7	3.82649036140572
NA	NA	hsa04518	Integrin signaling	45/1666	154/9376	1.64450195662681	FBN1/EGFR/ITGA6/ITGB4/CDH1/LAMC1/LAMB1/LAMA5/ITGAV/MET/ITGB1/COL4A2/IGF1R/ITGB8/FRAS1/ITGB5/COL4A1/FLT1/FERMT1/ACTN4/TLN1/VCL/PIK3R1/PIK3CA/PDGFD/FREM2/LAMB2/GSK3B/LAMB4/PIK3R3/PIK3CB/ERBB2/ITGB6/FN1/AKT3/MTOR/FLNB/PXN/PTK2/CCND1/LIMS1/ITGA3/AKT2/RAC3/NCK2	3.74859040607253
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	67/1666	253/9376	1.4903795510299	EGFR/ITGB1/JUN/ROCK1/RPS6KA5/WASF2/ACTN4/ITPR2/DIAPH1/TLN1/MAPK14/FBXW11/VCL/PIK3R1/ROCK2/CYTH3/ATM/BCL2/TAB3/TAB2/PIK3CA/NFKBIA/PFN2/NFKB1/GSK3B/FOXO4/ATG12/MDM2/WASL/U2AF1/PIK3R3/DOCK1/PIK3CB/ACTR2/RPS6KB1/IKBKB/AKT3/MALT1/CAST/MTOR/PLCG2/PXN/PTK2/CRK/BCAR1/ATG14/PIK3R4/MAPK1/FOXO3/CUL1/NAIP/MAPK8/AKT2/RRAGC/CRKL/TECPR1/TRAF5/MAP3K7/BCL2L1/RRAGB/WIPI1/FNBP1L/WIPI2/ARPC1B/TBK1/RPTOR/PLCB1	3.67552789009781
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	37/1666	122/9376	1.70680731308917	IGF1R/CREB3L2/HMGCR/PIK3R1/FASN/IRS2/PIK3CA/INSR/CPT1A/CREB1/PPP2R5E/PDPK1/PIK3R3/PIK3CB/PPP2R3A/TSC1/RPS6KB1/PRKAB2/AKT3/TSC2/MTOR/ACACA/PPP2R2A/CCND1/G6PC3/FOXO3/AKT2/PRKAA1/MAP3K7/ADIPOR2/STRADB/CAMKK2/PFKFB4/CAB39/RPTOR/PPP2R3B/TBC1D1	3.65268439988698
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	37/1666	122/9376	1.70680731308917	JUN/FOS/DLG1/MAPK14/NFATC3/PIK3R1/KRAS/PPP3CA/PIK3CA/NFKBIA/PAK6/PTPN11/NFKB1/PPP2R5E/NFATC2/GSK3B/VAV3/PDPK1/PIK3R3/SOS1/PIK3CB/PPP2R3A/SOS2/IKBKB/AKT3/MALT1/PPP2R2A/MAPK1/MAP2K7/MAPK8/AKT2/MAP3K7/NCK1/HRAS/PTPN6/PPP2R3B/NCK2	3.65268439988698
Human Diseases	Cancer: specific types	hsa05218	Melanoma	25/1666	73/9376	1.92734628097814	EGFR/CDH1/MET/CDK6/IGF1R/GADD45B/PIK3R1/KRAS/PIK3CA/PDGFD/POLK/CDKN1A/BRAF/MDM2/PIK3R3/PTEN/PIK3CB/AKT3/CCND1/MAPK1/AKT2/E2F3/RB1/HRAS/GADD45A	3.69732648616665
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	40/1666	137/9376	1.64316821619159	JUN/FOS/CTSC/CTSD/SPTAN1/GADD45B/ITPR2/CTSL/CTSO/CFLAR/PARP1/PIK3R1/CTSF/CTSV/ATM/PMAIP1/BCL2/KRAS/XIAP/MCL1/PIK3CA/NFKBIA/BIRC2/CTSB/NFKB1/DDIT3/PDPK1/PIK3R3/PIK3CB/IKBKB/AKT3/CASP2/ERN1/MAPK1/PIDD1/MAPK8/AKT2/BCL2L1/HRAS/GADD45A	3.52507468093032
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	26/1666	78/9376	1.87595038015206	CDH1/MET/ITGB1/CLTC/WASF2/GAB1/VCL/PIK3R1/PIK3CA/CBL/CD2AP/WASL/PIK3R3/DOCK1/PIK3CB/ELMO3/ACTR2/FN1/PXN/PTK2/SHC1/CRK/BCAR1/ARHGAP10/CRKL/ARPC1B	3.6110041169617
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	32/1666	103/9376	1.74845860674367	FUS/MSI2/PNN/SMG1/UPF2/RNMT/PABPN1/PCF11/UPF3A/DDX39B/CPSF2/UPF1/PABPC1/WDR82/SYMPK/PPP2R5E/GSPT2/CPSF7/SMG6/PABPC4/PPP2R3A/SMG7/PPP2R2A/SRRM1/NCBP1/CASC3/DDX19A/SMG5/TARDBP/NXF1/PPP2R3B/PPP1CB	3.55035856976925
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	32/1666	104/9376	1.73164650475575	PLPP3/CDS1/PLD3/PISD/GPD1L/LYPLA1/AGPAT1/GPCPD1/GPAM/CHPT1/SGMS1/ETNK1/LPIN2/DGKH/PLA2G15/DGKA/PNPLA6/LPIN1/GPAT4/PTDSS1/DGKD/AGPAT3/MBOAT7/SAMD8/GPD2/DGKZ/CDIPT/GNPAT/PTDSS2/LPCAT3/CEPT1/GDPD5	3.48760432926605
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	22/1666	63/9376	1.96528135063549	ASH1L/KMT2C/SETD2/NSD1/KMT2A/HADHA/PRDM2/KMT2E/KMT2B/PLOD1/EHMT1/DHTKD1/PLOD2/SETD7/KMT2D/PLOD3/EZH1/KMT5B/SETD1B/SETDB2/SETDB1/PHYKPL	3.5733481926779
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	25/1666	75/9376	1.87595038015206	CDK6/GADD45B/MDM4/ZMAT3/ATM/PMAIP1/BCL2/PPP1R13L/SIAH1/ATR/STEAP3/CDKN1A/MDM2/PTEN/SESN2/TSC2/CCND1/SESN1/RRM2B/ZNF385A/SESN3/PIDD1/BCL2L1/SHISA5/GADD45A	3.54030976246565
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	9/1666	17/9376	2.97945060377092	NRP2/DAG1/MYH10/TFRC/PCDH11X/LAMP2/LAMP1/PCDH11Y/MYH9	3.79708529890984
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	87/1666	362/9376	1.35254985972289	EGFR/CSF3R/ITGA6/ITGB4/LAMC1/LAMB1/LAMA5/HSP90B1/ITGAV/MET/ITGB1/COL4A2/CDK6/IGF1R/PRLR/ITGB8/PKN2/ITGB5/COL4A1/FLT1/CREB3L2/ERBB3/FGFR2/EFNA5/PIK3R1/BCL2/KRAS/THEM4/MCL1/RXRA/PHLPP1/PIK3CA/PDGFD/INSR/ATF6B/LAMB2/GHR/CDKN1A/GNG12/MAGI1/NFKB1/CREB1/PPP2R5E/GNB4/GSK3B/EPHA2/LAMB4/PDPK1/MDM2/PIK3R3/SOS1/PTEN/PIK3CB/ERBB2/ITGB6/PPP2R3A/TSC1/SOS2/FN1/RPS6KB1/IKBKB/IL4R/AKT3/TSC2/MTOR/PPP2R2A/ATF2/PTK2/NR4A1/CCND1/G6PC3/SGK3/MAPK1/FOXO3/ANGPT1/ITGA3/YWHAG/PHLPP2/AKT2/PRKAA1/JAK1/BCL2L1/HRAS/ANGPT2/RBL2/RPTOR/PPP2R3B	3.17988930704738
NA	NA	hsa04519	Cadherin signaling	95/1666	404/9376	1.32338083748351	EGFR/CDH1/MET/DSC3/GJA1/LRP5/IGF1R/CTNND1/DSP/DSC2/GABRE/DSG2/ROCK1/TEAD1/TMC5/RERE/FAT1/PCDH11X/TAOK1/ACTN4/LATS2/TCF7L2/DAAM1/MYO1C/ADAM10/TAOK3/MAPK14/FZD5/NCSTN/EP300/RYK/DVL3/VCL/ROCK2/NCKAP1/KRAS/MYO7A/CREBBP/AMOTL1/LIMA1/CYFIP2/FZD3/TJP1/EVL/PKP2/NFKBIA/FZD6/APC/ABI2/WWC1/CSNK1A1/KRT80/CDH3/CYFIP1/YAP1/NFKB1/PSEN1/GSK3B/VAV3/MPDZ/TEAD3/ERBB2/ACTR2/SAV1/FZD10/LATS1/IKBKB/AMOTL2/FMN1/ENAH/PTK2/SHOC2/TMC1/JUP/MAPK1/ATN1/YWHAG/LRP6/PCDH11Y/MAPK8/MYO1D/ARHGAP35/GABRA4/TMC4/LIMD1/PCDHGC3/MRAS/HRAS/ARPC1B/PSEN2/WWTR1/RAC3/PRICKLE1/PPP1CB/WNT4	3.08856168295906
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	24/1666	75/9376	1.80091236494598	REV3L/PIK3R1/ATM/PMAIP1/BCL2/XIAP/TOP2B/PIK3CA/ATP7B/CDKN1A/BIRC2/PDPK1/MDM2/MSH6/PIK3R3/PIK3CB/ERBB2/AKT3/MSH3/MAPK1/AKT2/ATP7A/BCL2L1/MSH2	3.23703023452707
NA	NA	hsa04517	IgSF CAM signaling	73/1666	299/9376	1.37402385703445	NRP2/CDH1/ITGB1/APP/IQGAP1/MYH10/NRP1/PTPRF/RASA1/ANK3/SPTBN1/LMO7/SPTAN1/ACTN4/PLXNA1/SORBS1/CADM1/ERC1/PPFIA1/MTSS1/MAPK14/NRCAM/PRKCI/SRGAP1/RAPGEF2/VCL/PIK3R1/RDX/JAM3/TJP2/NLGN4X/GRIP1/TJP1/TRIO/PIK3CA/F11R/PARD3/PAK6/CNTNAP2/MAGI1/PTPN11/DYNLL2/PLXNA2/CD2AP/EPB41L3/GSK3B/VAV3/MPDZ/PDPK1/WASL/PARD6B/PIK3R3/PIK3CB/BAIAP2/ROBO1/ACTR2/RAPGEF6/AKT3/PLCG2/PXN/PTK2/EPB41L2/BCAR1/MAPK1/MYLK3/MAPK8/AKT2/NCK1/ABL1/ARPC1B/PTPN6/MYH9/NCK2	3.05534093433189
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	13/1666	32/9376	2.28631452581032	ATG9A/ATG12/ATG2A/ULK2/MTOR/ATG9B/PIK3R4/ATG13/WIPI1/ATG4B/WIPI2/ATG4D/RPTOR	3.38806470574926
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	53/1666	205/9376	1.45500541680087	IL6ST/JUN/CDK6/DDB1/DLG1/UBR4/CREB3L2/SCIN/ACTN4/RBPJ/CHD4/EP300/PIK3R1/SKP2/PMAIP1/KRAS/CREBBP/PIK3CA/NFKBIA/UBE3A/ATF6B/REL/CDKN1A/NFKB1/CREB1/RASA2/LTBR/MDM2/USP7/PIK3R3/PIK3CB/ATF2/PXN/CCND1/EIF2AK2/DDX3X/MAPK1/YWHAG/STAT5B/TRAF5/HDAC6/GTF2H3/RBL1/SCRIB/JAK1/HDAC2/RB1/GTF2H2/HRAS/KAT2B/RBL2/HDAC7/SRF	3.0618301724507
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	47/1666	178/9376	1.48600563821034	LGR5/RNF43/JUN/LGR4/TLE4/LRP5/ZNRF3/TBL1X/TCF7L2/DAAM1/SERPINF1/FZD5/CHD8/TBL1XR1/NFATC3/EP300/RYK/DVL3/FBXW11/ROCK2/CAMK2G/CREBBP/TLE1/PPP3CA/SIAH1/FZD3/FZD6/APC/CSNK1A1/CTBP1/NFATC2/PSEN1/GSK3B/FZD10/SMAD4/CCND1/CUL1/LRP6/MAPK8/CSNK1E/TLE3/MAP3K7/RAC3/PLCB1/PRICKLE1/WNT4/NOTUM	3.04299020092342
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	12/1666	29/9376	2.32876598915428	TEAD1/FRMD6/RASSF6/LATS2/WWC1/YAP1/TEAD3/SAV1/LATS1/CSNK1E/LIMD1/WWTR1	3.33125078552717
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	33/1666	115/9376	1.6149485881309	EGFR/FOS/LRP5/AKAP13/GNAQ/GNA12/JUND/CREB3L2/ITPR2/WNK1/EGR1/MMP15/MMP14/ADCY7/PDE4B/BCL2/GATA3/RXRA/ATF6B/WNK2/CDKN1A/BRAF/CREB1/SP1/ATF2/MEF2A/GNA11/MAPK1/LRP6/ADCY6/GNA13/PLCB1/ARHGEF11	3.08428665321639
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	22/1666	68/9376	1.82077536897112	DUSP6/TCF7L2/PIK3R1/KRAS/PIK3CA/BRAF/NFKB1/PIK3R3/SOS1/PIK3CB/SOS2/RPS6KB1/IKBKB/AKT3/MTOR/CCND1/JUP/MAPK1/AKT2/STAT5B/CEBPA/HRAS	3.1575230658084
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	14/1666	37/9376	2.12945718828072	CDH1/TPR/GADD45B/TCF7L2/KRAS/RXRA/POLK/CDKN1A/BRAF/NCOA4/CCND1/MAPK1/HRAS/GADD45A	3.19975256452541
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	42/1666	157/9376	1.50553979553605	LRP1/ITGAV/SLC2A1/PBX1/ABCA1/ITGB5/DNMT3A/ANO6/ATP2A2/ADAM10/MAPK14/NFATC3/LIPA/CAMK2G/TMEM30A/ADAM17/RXRA/ATP11B/SLC16A1/RAB5B/CD47/CPT1A/TMEM30B/PTPN11/CREB1/TGFBRAP1/PLA2G15/NFATC2/ARNT/VPS8/DOCK1/SIRPA/PTK2/CRK/BCAR1/MAPK1/GULP1/ADAM9/XKR8/CRKL/VPS39/PTPN6	2.96933511946991
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	36/1666	130/9376	1.55848185428017	EGFR/COL4A2/JUN/FOS/COL4A1/CREB3L2/MAPK14/ADCY7/PIK3R1/KRAS/TGFBR1/SMAD2/PIK3CA/NFKBIA/ATF6B/GNG12/NFKB1/CREB1/TGFBR2/GNB4/PIK3R3/SOS1/PIK3CB/SOS2/AKT3/ATF2/EDN1/SHC1/MAPK1/MAP2K7/MAPK8/AKT2/EDNRB/ADCY6/HRAS/PLCB1	2.9805728850874
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	15/1666	41/9376	2.05896992943519	EGFR/CDH1/RPS6KA5/KRAS/CDKN1A/BRAF/MDM2/ERBB2/TYMP/DAPK1/CCND1/MAPK1/E2F3/RB1/HRAS	3.15874336700712
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	54/1666	214/9376	1.42011197002165	JUN/FOS/DDB1/GNAQ/ITPR2/PDIA3/MAPK14/NFATC3/FBXW11/PIK3R1/ATM/BCL2/KRAS/CUL5/PPP3CA/ATR/TAB2/PIK3CA/NFKBIA/LIMK2/TAPBP/PAK6/AP1S3/GNG12/NFKB1/NFATC2/GNB4/PIK3R3/PIK3CB/RPS6KB1/AP1B1/IKBKB/AKT3/MTOR/PLCG2/PXN/PTK2/CRK/GNA11/MAPK1/MAP2K7/CUL1/MAPK8/AKT2/CRKL/TRAF5/MAP3K7/BCL2L1/AP1S1/HRAS/WEE1/TBK1/AP1G2/RAC3	2.88983300248163
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	27/1666	91/9376	1.66980198672876	JUN/FOS/NFATC3/PIK3R1/KRAS/PPP3CA/PIK3CA/NFKBIA/NFKB1/INPPL1/NFATC2/GSK3B/VAV3/PIK3R3/SOS1/PIK3CB/SOS2/IKBKB/AKT3/MALT1/PLCG2/MAPK1/AKT2/BLNK/HRAS/PTPN6/RAC3	2.98450369710615
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	31/1666	110/9376	1.58603077594674	EGFR/SLC2A1/IGF1R/FLT1/TFRC/EPAS1/EP300/PIK3R1/CAMK2G/BCL2/CREBBP/PIK3CA/INSR/CDKN1A/NFKB1/ARNT/LTBR/PIK3R3/PIK3CB/ERBB2/RPS6KB1/AKT3/MTOR/PLCG2/EDN1/MAPK1/ANGPT1/AKT2/MKNK1/ANGPT2/VHL	2.87386634386195
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	22/1666	71/9376	1.74384119845121	EGFR/MET/JUN/ADAM10/ATP6V1B1/MAPK14/ATP6V0A1/ADAM17/JAM3/ATP6AP1/TJP1/F11R/NFKBIA/PTPN11/NFKB1/ATP6V1A/IKBKB/PLCG2/ATP6V1H/TCIRG1/ATP6V0B/MAPK8	2.92446994130239
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	44/1666	170/9376	1.45662029517689	ITGB1/JUN/MYH10/DLG1/ROCK1/AMOT/ACTN4/CLDN4/PRKCI/RAPGEF2/ROCK2/RDX/JAM3/TJP2/AMOTL1/MAP3K1/TJP1/F11R/MARVELD3/MARVELD2/OCLN/PARD3/MAGI1/NEDD4/SYMPK/MPDZ/PARD6B/ERBB2/ACTR2/RAPGEF6/SYNPO/PRKAB2/ARHGAP17/AMOTL2/PPP2R2A/CCND1/MAP2K7/TIAM1/MAPK8/PRKAA1/EPB41L4B/SCRIB/ARPC1B/MYH9	2.79280191485505
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	26/1666	90/9376	1.62582366279845	EGFR/JUN/FOS/EML4/MAPK14/NFATC3/PIK3R1/KRAS/PPP3CA/PIK3CA/NFKBIA/PTPN11/NFKB1/NFATC2/PIK3R3/PTEN/PIK3CB/RPS6KB1/IKBKB/AKT3/MTOR/MAPK1/AKT2/JAK1/HRAS/PTPN6	2.77303175480704
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	9/1666	21/9376	2.41193620305265	CHPF/DSE/XYLT1/CHST12/CHST14/B3GAT3/CHST11/CHPF2/CHSY1	3.0109169264164
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	23/1666	78/9376	1.65949456705759	XRN1/DHX36/CNOT6L/CNOT1/PABPC1/BTG2/DCP2/BTG1/XRN2/DIS3L/DDX6/PABPC4/TOB1/CNOT4/CNOT6/TOB2/PARN/PNPT1/CNOT2/DCP1A/DIS3/PAN2/LSM1	2.71869006592067
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	70/1666	300/9376	1.31316526610644	EGFR/MET/JUN/FOS/IGF1R/RASA1/NF1/FLT1/RPS6KA5/GNA12/TAOK1/DUSP6/JUND/ERBB3/GADD45B/MAP3K4/DUSP1/TAOK3/MAPK14/MAP3K2/NFATC3/FGFR2/EFNA5/RAPGEF2/KRAS/MAP3K1/PPP3CA/TAB2/TGFBR1/MAP4K4/PDGFD/INSR/MAP4K3/STK4/GNG12/BRAF/NFKB1/RASA2/TGFBR2/EPHA2/DDIT3/RPS6KA3/ELK4/HSPA1A/SOS1/ERBB2/HSPA1B/PPM1B/SOS2/IKBKB/AKT3/ATF2/NR4A1/CRK/MAPK1/MAP2K7/MAPKAPK5/ANGPT1/MAPK8/AKT2/PPM1A/CRKL/MAP3K7/MKNK1/MRAS/HRAS/ANGPT2/RAC3/GADD45A/SRF	2.56261237413406
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	29/1666	105/9376	1.55435888641171	JUN/HUWE1/USP8/KRAS/ATG9A/SIAH1/RAB5B/NBR1/RHOT1/AMFR/SMURF2/CITED2/ARIH1/SP1/ATG9B/MTX3/FOXO3/MAPK8/USP15/MON1B/BCL2L1/MRAS/HRAS/OPA1/MFN2/TFE3/TBK1/TOMM7/BCL2L13	2.6553288886345
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	21/1666	70/9376	1.68835534213685	SLC2A1/ACSL3/RXRA/IRS2/NFKBIA/APPL1/CPT1A/PTPN11/NFKB1/PRKAB2/IKBKB/AKT3/MTOR/PPARA/G6PC3/MAPK8/AKT2/PRKAA1/ADIPOR2/CAMKK2/ACSL1	2.68705237007442
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	16/1666	49/9376	1.8376656785163	GALNT11/C1GALT1/GXYLT1/B4GALT1/OGT/GALNT1/GALNT6/GALNT18/PLOD3/C1GALT1C1/POGLUT1/FUT10/GALNT7/POFUT1/RFNG/POMT2	2.73271110026506
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	28/1666	101/9376	1.56019635577003	COL4A2/JUN/COL4A1/DIAPH1/EGR1/MAPK14/PIK3R1/BCL2/KRAS/TGFBR1/SMAD2/PIK3CA/NFKB1/TGFBR2/PIK3R3/PIK3CB/FN1/AKT3/SMAD4/PLCG2/EDN1/CCND1/MAPK1/MAPK8/AKT2/STAT5B/HRAS/PLCB1	2.63111575265761
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	8/1666	19/9376	2.36962153282366	GNS/GLB1/HEXA/HGSNAT/NAGLU/GUSB/IDS/SGSH	2.77782580924563
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	51/1666	212/9376	1.35386984982672	EGFR/CDH1/MET/ITGB1/IGF1R/CTNND1/GNAQ/FLT1/TLN1/MAPK14/PRKCI/FGFR2/EFNA5/ADCY7/RAPGEF2/PIK3R1/KRAS/KRIT1/EVL/PIK3CA/PDGFD/INSR/PARD3/RAPGEF1/PFN2/MAGI3/MAGI1/BRAF/EPHA2/VAV3/PARD6B/PIK3R3/PIK3CB/RAPGEF6/ID1/AKT3/ENAH/CRK/PRKD2/BCAR1/MAPK1/TIAM1/ANGPT1/AKT2/CRKL/ADCY6/MRAS/HRAS/ANGPT2/RAC3/PLCB1	2.422506213632
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	54/1666	227/9376	1.33878397173848	EGFR/MT-ND3/MT-CO2/SLC26A2/MT-ND4/MT-CO3/MT-CYB/MT-CO1/MET/MT-ND1/MT-ND6/JUN/MT-ND2/MT-ND4L/FOS/MT-ATP6/MT-ND5/COX6A1/MAPK14/PIK3R1/KRAS/CAT/PIK3CA/NFKBIA/PTPN11/BRAF/NFKB1/ARNT/PDPK1/NDUFB9/CBR1/PIK3R3/SOS1/PTEN/PIK3CB/SOS2/NFE2L2/IKBKB/AKT3/PTK2/NDUFC1/PRKD2/ABL2/MAPK1/MAP2K7/MT-ATP8/FOXO3/NDUFS1/MAPK8/AKT2/NDUFB7/PTPN1/HRAS/ABL1	2.40184467009778
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	56/1666	238/9376	1.32420026834263	EGFR/MET/IGF1R/RASA1/NF1/FLT1/GAB1/FGFR2/EFNA5/PIK3R1/KRAS/RASAL2/PIK3CA/RAB5B/PDGFD/INSR/REL/RALGAPB/PAK6/STK4/GNG12/PTPN11/NFKB1/RASA2/KSR1/GNB4/RALGAPA1/EPHA2/FOXO4/PIK3R3/SOS1/PIK3CB/RALGAPA2/SOS2/IKBKB/AKT3/PLCG2/RALBP1/SHOC2/SHC1/ABL2/MAPK1/TIAM1/ANGPT1/MAPK8/AKT2/EXOC2/BCL2L1/RGL1/MRAS/HRAS/ABL1/ANGPT2/TBK1/RAC3/ETS2	2.35489864259483
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	36/1666	142/9376	1.42677916236917	JUN/FOS/FOSB/JUND/ATP2A2/ITPR2/MAPK14/PIK3R1/PPP3CA/TAB2/TGFBR1/PIK3CA/NFKBIA/TMEM64/JUNB/NFKB1/CREB1/TGFBR2/NFATC2/CYLD/PIK3R3/PIK3CB/IKBKB/AKT3/SOCS1/SIRPA/PLCG2/MAPK1/MAP2K7/MAPK8/AKT2/TYK2/MAP3K7/FOSL2/BLNK/JAK1	2.38203638807097
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	29/1666	112/9376	1.45721145601098	ITGA6/LAMC1/LAMB1/LAMA5/ITGB1/MAPK14/IL10RB/BCL2/XIAP/LDLR/TAB2/NFKBIA/LAMB2/BIRC2/NFKB1/LAMB4/PDPK1/HSPA1A/HSPA1B/IKBKB/AKT3/SOCS1/MAPK1/MAPK8/AKT2/TYK2/MAP3K7/JAK1/BCL2L1	2.26267818380009
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	38/1666	155/9376	1.37973124733764	EGFR/PBX1/CDK6/GNAQ/CREB3L2/ITPR2/TCF7L2/KMT2A/FZD5/DVL3/NCEH1/ADCY7/USP8/CAMK2G/FZD3/LDLR/FZD6/APC/ATF6B/CDKN1A/BRAF/CREB1/GSK3B/ARNT/SP1/FZD10/KMT2D/ATF2/NR4A1/CCND1/GNA11/MAPK1/ADCY6/E2F3/RB1/PLCB1/WNT4/MEN1	2.21589471476598
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	47/1666	200/9376	1.3225450180072	ITGB1/JUN/MYH10/FOS/ROCK1/WASF2/GNA12/MYO1C/CLDN4/MAPK14/ROCK2/CYTH3/SEC24D/NCKAP1/TAB3/CYFIP2/WIPF2/TJP1/TAB2/NFKBIA/MYO6/OCLN/ARHGEF12/CYFIP1/PTPN11/NFKB1/SEC24A/WASL/SEC24B/MYO5B/BAIAP2/ACTR2/IKBKB/ABI1/MAPK1/NAIP/MAPK8/MYO1D/GNA13/MAP3K7/NCK1/ABL1/ARPC1B/PTPN6/ARHGEF11/MYH9/NCK2	2.14325863094625
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	48/1666	205/9376	1.31774075483852	MT-ND3/MT-CO2/MT-ND4/MT-CO3/MT-CYB/MT-CO1/MT-ND1/SLC2A1/MT-ND6/MT-ND2/MT-ND4L/MT-ATP6/MT-ND5/COX6A1/CTSD/ATP2A2/MAPK14/PARP1/PIK3R1/CPT2/CAMK2G/GFPT1/TGFBR1/SMAD2/PIK3CA/INSR/NFKB1/TGFBR2/GSK3B/GSR/NDUFB9/PIK3R3/PTEN/PIK3CB/SP1/AKT3/MTOR/PPARA/NDUFC1/PDK2/MT-ATP8/NDUFS1/MAPK8/AKT2/NDUFB7/PDK4/PLCB1/PPP1CB	2.1381464797102
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	27/1666	105/9376	1.44716172183159	JUN/ITPR2/MAPK14/NFATC3/PIK3R1/KRAS/PPP3CA/PIK3CA/NFKBIA/ARHGEF12/PTPN11/NFKB1/NFATC2/KSR1/CYLD/MDM2/PIK3R3/PIK3CB/IKBKB/AKT3/MALT1/PLCG2/MAPK1/MAPK8/AKT2/MRAS/HRAS	2.14186417314711
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	84/1666	388/9376	1.2184007623668	MT-ND3/MT-CO2/MT-ND4/MT-CO3/LRP1/MT-CYB/MT-CO1/MT-ND1/APP/SLC39A10/MT-ND6/MT-ND2/MT-ND4L/LRP5/MT-ATP6/MT-ND5/MME/COX6A1/GNAQ/RTN4/RB1CC1/KIF5B/ATP2A2/ITPR2/ADAM10/ATF6/SLC11A2/FZD5/NCSTN/PSMD1/DVL3/PIK3R1/KRAS/ADAM17/XBP1/IRS2/PPP3CA/FZD3/PIK3CA/INSR/FZD6/APC/CSNK1A1/IDE/BRAF/NFKB1/SLC39A7/PSEN1/GSK3B/DDIT3/NDUFB9/PIK3R3/ATG2A/PIK3CB/ULK2/FZD10/IKBKB/AKT3/MTOR/ERN1/NDUFC1/EIF2AK2/ATG14/PIK3R4/MAPK1/MAP2K7/MT-ATP8/NDUFS1/LRP6/MAPK8/CSNK1E/SLC39A9/AKT2/NDUFB7/ATG13/SLC39A8/WIPI1/HRAS/WIPI2/PSEN2/KLC1/PLCB1/BACE1/WNT4	2.04237002859407
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	13/1666	42/9376	1.74195392442691	SLC40A1/TFRC/PCBP2/SLC11A2/ACSL3/GCLM/SLC3A2/STEAP3/NCOA4/SLC39A8/GCLC/ACSL1/LPCAT3	2.2400805279273
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	36/1666	149/9376	1.35974926883505	EGFR/PLPP3/GAB1/GNA12/ADCY7/PIK3R1/CYTH3/KRAS/PIK3CA/AGPAT1/PDGFD/INSR/PIP5K1A/PTPN11/DGKH/DGKA/PIK3R3/SOS1/PIK3CB/TSC1/SOS2/AKT3/TSC2/MTOR/PLCG2/DGKD/AGPAT3/SHC1/MAPK1/DGKZ/AKT2/ADCY6/GNA13/MRAS/HRAS/PLCB1	2.05758953092578
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	56/1666	248/9376	1.27080509623204	AHNAK/HSP90B1/JUN/FOS/DYNC1H1/GCC2/KIF5B/RHOB/SNX18/TCF7L2/MAPK14/ROCK2/CYTH3/NCKAP1/BCL2/TAB3/CYFIP2/DYNC1LI2/ACBD3/TAB2/PIK3C2A/PIK3CA/RAB5B/NFKBIA/MYO6/PFN2/CYFIP1/BIRC2/DYNLL2/NFKB1/EXOC4/WASL/DCTN4/EXOC5/PIK3CB/ACTR2/IKBKB/AKT3/DYNC1LI1/DCTN5/DCTN1/ABI1/MAPK1/MAP2K7/KPNA3/NAIP/MAPK8/AKT2/MAP3K7/PLEKHM1/EXOC2/HRAS/VPS39/ARPC1B/FHOD1/KLC1	2.00905027793269
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	16/1666	56/9376	1.60795746870177	LRP2/GLI3/FBXW11/BCL2/CSNK1A1/PTCH2/SMURF2/GSK3B/MGRN1/KIF3A/CCND1/MEGF8/CSNK1G3/CUL1/CSNK1E/SPOP	2.12107098510481
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	37/1666	156/9376	1.33481084741589	EGFR/CDK6/CLDN4/CFLAR/PIK3R1/KRAS/TLR3/RXRA/LDLR/PIK3CA/MAVS/PIAS1/NFKBIA/OCLN/CDKN1A/BRAF/NFKB1/GSK3B/PIK3R3/SOS1/PIK3CB/SOS2/IKBKB/AKT3/PPP2R2A/PPARA/CCND1/EIF2AK2/MAPK1/YWHAG/AKT2/TYK2/JAK1/E2F3/RB1/HRAS/TBK1	1.96016353826272
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	10/1666	31/9376	1.81543585176006	HSPA5/SEC62/SEC63/SEC61A1/SRPRA/TMEM208/SPCS3/SEC61A2/SRPRB/IMMP2L	2.1138635184358
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	45/1666	196/9376	1.29210868020678	IL6ST/JUN/CDK6/FOS/ITPR2/TCF7L2/MAPK14/NFATC3/EP300/PIK3R1/KRAS/CREBBP/TLR3/PPP3CA/PIK3CA/NFKBIA/CDKN1A/GNG12/NFKB1/CREB1/NFATC2/GNB4/GSK3B/PIK3R3/PIK3CB/IKBKB/AKT3/MTOR/PLCG2/RCAN1/CCND1/EIF2AK2/ATG14/MAPK1/MAP2K7/MAPK8/AKT2/TYK2/JAK1/E2F3/RB1/ZFP36/HRAS/ANGPT2/TBK1	1.9210873192227
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	46/1666	201/9376	1.28796593264171	MET/SPINT1/PBX1/FUS/IGF1R/FLT1/DUSP6/GADD45B/NCOR1/JMJD1C/FUT8/KMT2A/SIN3A/DDX5/ATM/CCNT1/RXRA/NFKBIZ/ETV6/REL/POLK/CDKN1A/ID2/BMI1/BIRC2/NFKB1/TGFBR2/DDIT3/ELK4/MDM2/EWSR1/SP1/KLF3/PTK2/ASPSCR1/CCNT2/JUP/KDM6A/SIX4/HDAC2/BCL2L1/CEBPA/SS18/TFE3/GADD45A/MEN1	1.91836857782381
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	22/1666	86/9376	1.43968284988414	ITGA6/ITGB4/DAG1/ITGAV/ITGB1/GJA1/DSP/DSC2/ITGB8/DSG2/ITGB5/ATP2A2/TCF7L2/DMD/SSPN/PKP2/ITGB6/JUP/ITGA3/SNTB1/SNTB2/SGCE	1.90404339583769
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	33/1666	139/9376	1.33610854413708	EGFR/HSP90B1/JUN/FOS/NCOA3/GNAQ/CTSD/CREB3L2/ITPR2/ADCY7/PIK3R1/NCOA2/BCL2/KRAS/PIK3CA/ATF6B/NCOA1/CREB1/HSPA1A/PIK3R3/SOS1/PIK3CB/SP1/HSPA1B/SOS2/AKT3/ATF2/SHC1/MAPK1/AKT2/ADCY6/HRAS/PLCB1	1.85574128095883
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	34/1666	144/9376	1.32879818594104	GNAQ/PUM1/RB1CC1/PUM2/ATP2A2/ITPR2/RBPJ/PSMD1/ATXN2/PIK3R1/VLDLR/XBP1/AFG3L2/PIK3CA/PIK3R3/ATG2A/PIK3CB/SP1/ULK2/AKT3/OMA1/MTOR/NOP56/ERN1/ATXN1/ATG14/PIK3R4/MAPK8/AKT2/ATG13/WIPI1/OPA1/WIPI2/PLCB1	1.8482414619119
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	9/1666	28/9376	1.80895215228949	GCNT2/B3GNT2/B4GALT1/ST3GAL6/B3GNT3/B3GNT5/B4GALT4/FUT4/B3GALNT1	1.99268405800135
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	33/1666	140/9376	1.32656491167896	CDH1/GNAQ/SLC9A1/JAG1/ITPR2/NOTCH3/EGR1/ADCY7/KRAS/PDE3B/TGFBR1/SMAD2/GNG12/GNB4/TFAM/RPS6KB1/PRKAB2/AKT3/SMAD4/MTOR/MEF2A/APELA/CCND1/PIK3R4/MAPK1/MYLK3/AKT2/PRKAA1/ADCY6/GNA13/MRAS/HRAS/PLCB1	1.80962056408766
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/1666	24/9376	1.87595038015206	EXTL2/HS6ST2/XYLT1/B3GAT3/GLCE/EXT1/EXT2/NDST1	1.99723342171529
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	48/1666	216/9376	1.25063358676804	HSP90B1/JUN/HSPA5/FOS/ABCA1/ATF6/MIB1/MAPK14/NFATC3/PIK3R1/ROCK2/VLDLR/CAMK2G/BCL2/KRAS/XBP1/RXRA/PPP3CA/LDLR/TAB2/PIK3CA/NFKBIA/OLR1/NFKB1/NFATC2/GSK3B/DDIT3/VAV3/PDPK1/POU2F1/HSPA1A/PIK3R3/PIK3CB/HSPA1B/NFE2L2/IKBKB/AKT3/ERN1/PTK2/MAPK1/MAP2K7/MAPK8/AKT2/MAP3K7/BCL2L1/HRAS/TBK1/PLCB1	1.73226509991074
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	18/1666	69/9376	1.468135080119	MAPK14/PIK3R1/KRAS/PIK3CA/VAV3/PDPK1/PIK3R3/SOS1/PIK3CB/SOS2/AKT3/PLCG2/MAPK1/MAP2K7/MAPK8/AKT2/HRAS/RAC3	1.81420693485279
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	16/1666	60/9376	1.50076030412165	MAPK14/PIK3R1/KRAS/PPP3CA/PIK3CA/NFATC2/PIK3R3/PIK3CB/AKT3/PLCG2/PXN/PTK2/MAPK1/AKT2/HRAS/RAC3	1.80878408237795
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	23/1666	93/9376	1.39183415301605	JUN/FOS/MAML2/JAG1/NOTCH3/RBPJ/MAPK14/NFATC3/GATA3/PPP3CA/NFKBIA/MAML3/NFKB1/NFATC2/MAML1/IKBKB/IL4R/NOTCH2/MAPK1/MAPK8/STAT5B/TYK2/JAK1	1.76520656516497
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	14/1666	51/9376	1.5449003130664	ATP6V1B1/ATP6V0A1/PDIA4/SEC61A1/TJP2/ATP6AP1/TJP1/ATP6V1A/PLCG2/ATP6V1H/TCIRG1/ATP6V0B/SLC12A2/SEC61A2	1.8137343284331
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	33/1666	142/9376	1.30788089883841	HSP90B1/ITGAV/JUN/FOS/DUSP1/GPC1/CTSL/BMPR2/MAPK14/PIK3R1/BCL2/PIK3CA/BMPR1A/ACVR2B/NFKB1/PIK3R3/PIK3CB/TRPV4/NFE2L2/IKBKB/AKT3/ACVR2A/MEF2A/PTK2/EDN1/ACVR1/MAP2K7/BMP4/MAPK8/AKT2/PRKAA1/MAP3K7/RAC3	1.71841450776056
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	19/1666	75/9376	1.42572228891557	LRP2/HSP90B1/HSPA5/GNAQ/CREB3L2/ITPR2/CANX/PDIA4/ADCY7/ATP1A1/GPX8/ATF6B/CREB1/GSR/ATF2/TTF1/DUOX1/ADCY6/PLCB1	1.72063259483415
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	10/1666	34/9376	1.65525033542829	BHLHE41/FBXW11/CLOCK/NR1D2/CREB1/FBXL3/PRKAB2/CUL1/CSNK1E/PRKAA1	1.77919162948339
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	51/1666	235/9376	1.22136343899262	MT-ND3/MT-CO2/MT-ND4/MT-CO3/MT-CYB/MT-CO1/MT-ND1/MT-ND6/MT-ND2/MT-ND4L/MT-ATP6/MT-ND5/COX6A1/SMARCA2/ARID1A/CREB3L2/MAPK14/ADCY7/ACSL3/CPT2/KRAS/ARID1B/CPT1A/SMARCC1/CREB1/RPS6KA3/NDUFB9/SOS1/SMARCA4/SMARCD1/COX19/TSC1/SOS2/RPS6KB1/PRKAB2/TSC2/PNPLA2/MTOR/ATF2/NDUFC1/MT-ATP8/NDUFS1/FRS2/KDM3B/NDUFB7/PRKAA1/ADCY6/ACSL1/HRAS/COX15/RPTOR	1.59749282979862
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	18/1666	71/9376	1.42677916236917	EGFR/MET/SLC2A1/SLC1A5/IDH1/FGFR2/PIK3R1/KRAS/PIK3CA/PIK3R3/PTEN/PIK3CB/ERBB2/AKT3/MTOR/MAPK1/AKT2/HRAS	1.67791570905402
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	25/1666	105/9376	1.33996455725147	GADD45B/ERC1/CFLAR/PARP1/ATM/BCL2/XIAP/TAB3/PPP1R13L/TAB2/NFKBIA/BIRC2/NFKB1/CYLD/LTBR/IKBKB/MALT1/PLCG2/PIDD1/TRAF5/MAP3K7/EDARADD/BLNK/BCL2L1/GADD45A	1.62839945765972
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	9/1666	30/9376	1.68835534213685	PGAP1/GPAA1/PIGS/PIGT/PIGM/PIGG/PIGO/MPPE1/B3GALT4	1.75532029403085
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	8/1666	26/9376	1.73164650475575	SLC19A3/SLC19A1/LMBRD1/SLC52A3/SLC5A6/SLC19A2/ABCD4/SLC46A1	1.73651331815216
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	12/1666	44/9376	1.53486849285169	DYNC1H1/CREB3L2/DYNC1LI2/VAMP2/RAB5B/DYNLL2/CREB1/DCTN4/DYNC1LI1/DCTN5/DCTN1/ADCY6	1.65303457285312
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	16/1666	63/9376	1.4292955277349	GLI3/GADD45B/TCF7L2/FZD5/DVL3/FZD3/FZD6/APC/POLK/CDKN1A/PTCH2/GSK3B/FZD10/BMP4/GADD45A/WNT4	1.58919717774129
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	50/1666	233/9376	1.2076933777803	FBN1/FBN2/SYNE2/ITGA6/ITGB4/DAG1/ITGAV/ITGB1/COL4A2/FBLN1/MYH10/PLEC/DSP/DSC2/ITGB8/ANK3/DSG2/DIAPH2/ITGB5/SPTBN1/COL4A1/FMNL2/SPTAN1/DMD/DAAM1/DIAPH1/TLN1/SSPN/SUN1/VCL/ATP1A1/COL5A2/PKP2/INF2/TMEM43/LBR/ITGB6/FN1/BGN/SUN2/JUP/ITGA3/PDLIM5/SNTB1/NID1/SNTB2/SGCE/TTN/MYH9/HSPG2	1.49228645752899
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	35/1666	157/9376	1.25461649628004	MT-CO2/MT-CO3/MT-CYB/MT-CO1/JUN/FOS/COX6A1/MAPK14/PIK3R1/XBP1/RXRA/IRS2/PIK3CA/INSR/NFKB1/GSK3B/DDIT3/NDUFB9/PIK3R3/PIK3CB/ITCH/PRKAB2/IKBKB/AKT3/ERN1/PPARA/NDUFC1/NDUFS1/MAPK8/AKT2/NDUFB7/PRKAA1/ADIPOR2/MLXIP/CEBPA	1.4955137282497
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	18/1666	73/9376	1.38768932230426	RANBP2/AFF4/FURIN/EP300/SERINC3/XPO1/CREBBP/CCNT1/HGS/NUP153/CPSF7/BICD2/CCNT2/NELFA/TNPO3/SERINC5/ELL/KAT2B	1.54571601694204
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	14/1666	54/9376	1.45907251789605	MTR/DNMT3A/AHCYL1/GCLM/AHCYL2/MAT2A/BCAT1/AMD1/DNMT1/GCLC/BCAT2/MAT2B/LACC1/MRI1	1.57260471372238
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	22/1666	93/9376	1.33131962462404	EGFR/JUN/GNAQ/MAP3K4/ITPR2/EGR1/MMP14/MAPK14/MAP3K2/ADCY7/CAMK2G/KRAS/MAP3K1/SOS1/SOS2/GNA11/MAPK1/MAP2K7/MAPK8/ADCY6/HRAS/PLCB1	1.49258958682554
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	10/1666	36/9376	1.56329198346005	GALNT11/C1GALT1/B4GALT5/GCNT4/B3GNT3/GALNT1/GALNT6/GALNT18/C1GALT1C1/GALNT7	1.57400943231187
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	7/1666	23/9376	1.71282426013884	B4GAT1/B4GALT1/B3GALNT2/FKRP/POMGNT1/FUT4/POMT2	1.59098787738683
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	21/1666	89/9376	1.32791993201775	ITGA6/ITGB4/LAMC1/LAMB1/LAMA5/DAG1/ITGAV/ITGB1/COL4A2/ITGB8/FRAS1/ITGB5/COL4A1/FREM2/LAMB2/CD47/LAMB4/ITGB6/FN1/ITGA3/HSPG2	1.44484428192309
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	22/1666	94/9376	1.317156649894	HSP90B1/JUN/FOS/FOSB/JUND/MAPK14/TAB3/USP25/TAB2/NFKBIA/NFKB1/GSK3B/TRAF4/ANAPC5/IKBKB/MAPK6/MAPK1/MAPK8/TRAF5/MAP3K7/MAPK4/TBK1	1.43652409295191
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	75/1666	368/9376	1.14698053134297	MT-ND3/MT-CO2/MT-ND4/MT-CO3/MT-CYB/MT-CO1/MT-ND1/MT-ND6/MT-ND2/MT-ND4L/HSPA5/FUS/MT-ATP6/MT-ND5/COX6A1/RANBP2/TPR/RB1CC1/KIF5B/ATF6/MAPK14/SETX/C9orf72/PSMD1/ATXN2/BCL2/SPG11/XBP1/POM121/POM121C/GPX8/PPP3CA/SRSF7/CAT/NUP58/PFN2/UBQLN1/NUP210/NUP153/DDIT3/DCTN4/NDUFB9/ATG2A/NUP214/ALS2/ULK2/NUP160/MTOR/NUP98/ERN1/DNAH14/NDUFC1/NUP133/NUP155/NCBP1/DCTN5/DCTN1/ATG14/PIK3R4/MT-ATP8/NDUFS1/TARDBP/NDC1/NDUFB7/HDAC6/ATG13/NUP107/NXF1/BCL2L1/WIPI1/WIPI2/TBK1/KLC1/DERL1/NUP205	1.3371049030774
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	36/1666	166/9376	1.22049783768929	ATP2B1/ADRB1/ATP2B4/ROCK1/GTF2I/GNAQ/GNA12/CREB3L2/ATP2A2/ITPR2/PPP1R12A/NFATC3/ADCY7/ROCK2/ATP1A1/IRS2/PPP3CA/PDE3B/INSR/ATF6B/CREB1/NFATC2/RGS2/AKT3/ATF2/MEF2A/GNA11/MAPK1/MYLK3/AKT2/EDNRB/ADCY6/GNA13/PLCB1/PPP1CB/SRF	1.33236897566588
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	12/1666	47/9376	1.43689816352073	PIK3R1/IRS2/PIK3CA/INSR/PIK3R3/PIK3CB/IKBKB/MTOR/SOCS1/MAPK1/MAPK8/SOCS4	1.39574971974045
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	63/1666	308/9376	1.15115136963876	MT-ND3/MT-CO2/MT-ND4/MT-CO3/MT-CYB/MT-CO1/MT-ND1/MT-ND6/MT-ND2/MT-ND4L/MT-ATP6/MT-ND5/POLR2J3/CLTC/COX6A1/GNAQ/RB1CC1/KIF5B/CREB3L2/SLC1A3/POLR2A/PSMD1/EP300/AP2A2/RCOR1/REST/SIN3A/CREBBP/GPX8/TAF4B/AP2A1/AP2B1/HTT/CREB1/POLR2B/DCTN4/NDUFB9/ATG2A/TFAM/SP1/ULK2/MTOR/ERN1/DNAH14/NDUFC1/DCTN5/DCTN1/TGM2/POLR2L/ATG14/PIK3R4/MAP2K7/MT-ATP8/NDUFS1/MAPK8/NDUFB7/ATG13/POLR2J2/HDAC2/WIPI1/WIPI2/KLC1/PLCB1	1.2537981857221
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	14/1666	57/9376	1.38227922748047	HACD3/HADHA/ACSL3/CPT2/FASN/CPT1A/PPT1/ACACA/ACOX1/ELOVL4/HACD2/ACSL1/HSD17B12/ACADSB	1.34564164546342
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	36/1666	168/9376	1.20596810152632	EGFR/CSF3R/IL6ST/PRLR/LIFR/EP300/PIK3R1/IL10RB/BCL2/CREBBP/MCL1/SOCS7/PIK3CA/PIAS1/GHR/CDKN1A/PTPN11/PIK3R3/SOS1/PIK3CB/SOS2/SOCS5/IL4R/AKT3/MTOR/SOCS1/CCND1/AKT2/STAT5B/TYK2/SOCS6/JAK1/BCL2L1/HRAS/PTPN6/SOCS4	1.25218327639657
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	24/1666	107/9376	1.26232175113036	SLC2A1/GNAQ/PHKB/CREB3L2/ITPR2/EP300/CAMK2G/CREBBP/PPP3CA/PPP4R3A/PDE3B/CPT1A/CREB1/PRKAB2/AKT3/ACACA/ATF2/PPARA/G6PC3/PHKA2/PPP4R3B/AKT2/PRKAA1/PLCB1	1.26854447543255
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	43/1666	205/9376	1.18047609287617	JUN/CDK6/GADD45B/RBPJ/PDIA3/MAPK14/PSMD1/SIN3A/PIK3R1/SKP2/BCL2/TAB2/PIK3CA/MAVS/NFKBIA/TAPBP/POLK/CDKN1A/NFKB1/NEDD4/MDM2/USP7/PIK3R3/PIK3CB/IKBKB/AKT3/PLCG2/CCND1/HES1/EIF2AK2/MAP2K7/MAPK8/AKT2/TYK2/TRAF5/MAP3K7/BLNK/JAK1/HDAC2/E2F3/RB1/TBK1/GADD45A	1.21446278696969
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	38/1666	180/9376	1.18810190742964	PDIA3/CD74/PIK3R1/BCL2/SRSF2/TLR3/SRSF6/SRSF7/SRSF5/TAB2/PIK3CA/MAVS/NFKBIA/HCFC1/TAPBP/BIRC2/PTPN11/NFKB1/POU2F1/PIK3R3/PIK3CB/TSC1/SRSF8/IKBKB/AKT3/TSC2/MTOR/EIF2AK2/AKT2/TYK2/TRAF5/MAP3K7/JAK1/NXF1/BCL2L1/SRSF4/TBK1/PPP1CB	1.18447505371283
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	22/1666	98/9376	1.26339515397996	PLPP3/WASF2/SCIN/PIK3R1/PIK3CA/ASAP1/LIMK2/PIP5K1A/INPPL1/VAV3/PIK3R3/DOCK1/PIK3CB/ACTR2/RPS6KB1/AKT3/PLCG2/CRK/MAPK1/AKT2/CRKL/ARPC1B	1.21839913468336
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1666	21/9376	1.60795746870177	CSAD/PANK3/BCAT1/AASDHPPT/BCAT2/DPYD	1.29645335893916
Human Diseases	Infectious disease: viral	hsa05162	Measles	29/1666	136/9376	1.20005649318551	CD46/JUN/CDK6/FOS/ADAR/PIK3R1/BCL2/TAB2/PIK3CA/MAVS/NFKBIA/NFKB1/GSK3B/HSPA1A/PIK3R3/PIK3CB/HSPA1B/IKBKB/AKT3/CCND1/EIF2AK2/MAPK8/AKT2/STAT5B/TYK2/MAP3K7/JAK1/BCL2L1/TBK1	1.09240094715951
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	15/1666	65/9376	1.29873487856681	PBX1/GNAQ/CREB3L2/ITPR2/NCEH1/ADCY7/LDLR/ATF6B/CREB1/SP1/ATF2/NR4A1/GNA11/ADCY6/PLCB1	1.12341545438082
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	22/1666	101/9376	1.22586856524788	GNAQ/CREB3L2/TCF7L2/FZD5/EP300/DVL3/ADCY7/CAMK2G/KRAS/CREBBP/FZD3/FZD6/CREB1/GSK3B/FZD10/EDN1/MAPK1/EDNRB/ADCY6/HRAS/PLCB1/WNT4	1.06085363450282
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	22/1666	103/9376	1.20206529213627	JUN/FOS/GNAQ/MAPK14/CFLAR/PIK3R1/TGFBR1/SMAD2/PIK3CA/NFKBIA/NFKB1/TGFBR2/PIK3R3/PIK3CB/IKBKB/AKT3/PPP2R2A/GNA11/MAPK1/MAPK8/AKT2/PLCB1	0.958508907673816
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	12/1666	52/9376	1.29873487856681	LRP2/LRP1/ABCA1/LRPAP1/LIPA/NCEH1/NPC1/MYLIP/LDLR/SORT1/SOAT1/LIPG	1.00411260366306
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	23/1666	109/9376	1.18752822229809	IL6ST/JUN/FOS/MAPK14/NFATC3/GATA3/RXRA/PPP3CA/TGFBR1/SMAD2/NFKBIA/NFKB1/TGFBR2/NFATC2/IKBKB/IL4R/SMAD4/MTOR/MAPK1/MAPK8/STAT5B/TYK2/JAK1	0.915390185694486
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/1666	23/9376	1.468135080119	PCYOX1/HMGCR/ZMPSTE24/NUS1/MVK/HMGCS1	1.04485394100333
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	6/1666	23/9376	1.468135080119	ENPEP/MME/LNPEP/CTSA/ATP6AP2/PRCP	1.04485394100333
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/1666	28/9376	1.40696278511405	HACD3/HADHA/THEM4/PPT1/ELOVL4/HACD2/HSD17B12	1.00246751529303
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	8/1666	33/9376	1.3643275492015	IDH1/OGDH/DHTKD1/BCAT1/DBT/CS/BCAT2/ACO1	0.974544681207968
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	9/1666	38/9376	1.33291211221331	PIK3R1/ATP1A1/KRAS/PIK3CA/INSR/PDPK1/PIK3R3/PIK3CB/MAPK1	0.955851459091683
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1666	14/9376	1.60795746870177	B3GNT2/FUT8/B4GALT1/B4GALT4	1.05815392024284
Organismal Systems	Immune system	hsa04611	Platelet activation	26/1666	126/9376	1.16130261628461	ITGB1/ROCK1/GNAQ/ITPR2/TLN1/PPP1R12A/MAPK14/PRKCI/ADCY7/PIK3R1/ROCK2/PIK3CA/STIM1/ARHGEF12/PIK3R3/PIK3CB/AKT3/PLCG2/MAPK1/MYLK3/AKT2/ADCY6/GNA13/ARHGAP35/PLCB1/PPP1CB	0.847328404948759
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	24/1666	116/9376	1.16438299457714	ITGB1/CTNND1/ARHGAP5/ROCK1/ACTN4/CLDN4/MAPK14/VCL/PIK3R1/ROCK2/JAM3/PIK3CA/F11R/OCLN/PTPN11/VAV3/PIK3R3/PIK3CB/PLCG2/PXN/PTK2/BCAR1/CD99L2/ARHGAP35	0.828087705420993
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1666	19/9376	1.48101345801478	GLDC/OGDH/DHTKD1/DBT/AMT	0.975577242505283
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	13/1666	59/9376	1.24003499704967	ADRB1/ADCY7/PIK3R1/IRS2/PDE3B/PIK3CA/INSR/PIK3R3/PIK3CB/AKT3/PNPLA2/AKT2/ADCY6	0.859722854828802
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	12/1666	54/9376	1.25063358676804	REV3L/REV1/ATR/POLK/FANCM/HES1/USP1/ERCC4/TOP3A/BRCA2/FAN1/POLI	0.858573634019664
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	9/1666	39/9376	1.29873487856681	GLDC/MTR/AHCYL1/AHCYL2/MAT2A/AMT/MTHFD2L/MTHFR/MAT2B	0.86898144474546
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	14/1666	65/9376	1.21215255332902	PLPP3/AGPAT1/GPAM/LPIN2/DGKH/DGKA/LPIN1/GPAT4/PNPLA2/DGKD/AGPAT3/DGKZ/DGAT1/LIPG	0.797815970601084
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	14/1666	65/9376	1.21215255332902	GNAQ/KCNN4/ITPR2/PIK3R1/KRAS/PIK3CA/PIK3R3/PIK3CB/AKT3/GNA11/MAPK1/AKT2/HRAS/PLCB1	0.797815970601084
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	29/1666	144/9376	1.13338668800854	TRA2B/TCF7L2/MAPK14/TRA2A/FASN/TAB3/TAB2/NFKBIA/LPIN2/CPT1A/NFKB1/GSK3B/LPIN1/PRKAB2/IKBKB/AKT3/ACACA/ACOX1/PPARA/CCND1/MAP2K7/FOXO3/MAPK8/AKT2/PRKAA1/MAP3K7/ADIPOR2/CAMKK2/TBK1	0.749793696515985
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1666	15/9376	1.50076030412165	GLB1/HEXA/SLC33A1/B3GALT4	0.902215635357472
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	5/1666	20/9376	1.40696278511405	DHCR24/LIPA/LBR/SOAT1/SQLE	0.846877385274774
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/1666	30/9376	1.31316526610644	MTR/SLC19A1/FOLR1/NFKB1/IKBKB/SLC46A1/MTHFR	0.79857787589149
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	42/1666	217/9376	1.08926151105604	EGFR/HSP90B1/JUN/FOS/ADRB1/CREB3L2/JAG1/KPNB1/ADCY7/PIK3R1/KPNA6/BCL2/KRAS/XIAP/RXRA/PIK3CA/ATF6B/NFKB1/CREB1/ARNT/RPS6KA3/KLF5/PIK3R3/SOS1/PIK3CB/SOS2/RPS6KB1/AKT3/MTOR/NOTCH2/ATF2/PPARA/CCND1/MAPK1/KPNA3/AKT2/STAT5B/ADCY6/RB1/HRAS/KPNA5/KLF4	0.618395071409012
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/1666	31/9376	1.27080509623204	GLDC/ACSS1/CAT/CS/AMT/ACO1/PGP	0.702011092958234
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	13/1666	63/9376	1.16130261628461	POLR2J3/DDB1/POLR2A/XPC/POLR2B/RFC1/ERCC5/POLR2L/ERCC4/ERCC6/GTF2H3/POLR2J2/GTF2H2	0.597121670272982
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	37/1666	193/9376	1.07891446734134	ROCK1/GNAQ/ADCY7/PIK3R1/ROCK2/KRAS/PIK3CA/NFKBIA/PARD3/GNG12/BRAF/NFKB1/GNB4/GSK3B/VAV3/PIK3R3/SOS1/PIK3CB/SOS2/IKBKB/AKT3/PLCG2/PXN/PTK2/SHC1/CRK/BCAR1/MAPK1/TIAM1/FOXO3/AKT2/STAT5B/CRKL/ADCY6/HRAS/RAC3/PLCB1	0.51491902649794
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1666	32/9376	1.23109243697479	BIRC6/PMAIP1/BCL2/XIAP/BIRC2/MAPK8/BCL2L1	0.60868171335206
NA	NA	hsa03272	Virion - Hepatitis viruses	10/1666	48/9376	1.17246898759504	EGFR/TGOLN2/DPP4/CLDN4/IST1/LDLR/LAMP2/OCLN/LAMP1/HSPG2	0.556843701546836
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/1666	70/9376	1.12557022809124	DAG1/DMD/EIF4G1/SSPN/EIF4G2/EIF4G3/CCND1/ABL2/CD55/SNTB1/SNTB2/ABL1/SGCE/RAC3	0.490173836605833
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1666	12/9376	1.40696278511405	GGCX/COQ4/VKORC1L1	0.655708124841353
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	20/1666	103/9376	1.09278662921479	LAMC1/LAMB1/LAMA5/COL4A2/GNAQ/COL4A1/ACTN4/VCL/PIK3R1/PIK3CA/RAB5B/LAMB2/NFKB1/LAMB4/PIK3R3/PIK3CB/FN1/PTK2/GNA11/PLCB1	0.44013897525473
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	21/1666	109/9376	1.08426489862	JUN/FOS/MAPK14/PIK3R1/TLR3/TAB2/PIK3CA/NFKBIA/NFKB1/PIK3R3/PIK3CB/IKBKB/AKT3/MAPK1/MAP2K7/MAPK8/AKT2/TYK2/MAP3K7/JAK1/TBK1	0.411326147339432
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	9/1666	44/9376	1.15115136963876	GTF2I/TAF3/TAF4B/TAF2/TAF8/TAF5L/GTF2H3/TAF1/GTF2H2	0.467139947643659
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	22/1666	115/9376	1.07663239208727	FOS/GNAQ/CREB3L2/ITPR2/ADCY7/PIK3R1/CAMK2G/BCL2/KRAS/PIK3CA/GNG12/CREB1/GNB4/PIK3R3/PIK3CB/AKT3/GNA11/MAPK1/AKT2/ADCY6/HRAS/PLCB1	0.384351259082
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	5/1666	23/9376	1.22344590009917	MLH3/MSH6/RFC1/MSH3/MSH2	0.498720004619831
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	19/1666	99/9376	1.08009264311785	ITGA6/ITGB4/DAG1/ITGAV/ITGB1/ITGB8/ITGB5/ATP2A2/DMD/SSPN/ITGB6/PRKAB2/EDN1/ITGA3/SNTB1/PRKAA1/SNTB2/SGCE/TTN	0.372393757875654
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	35/1666	187/9376	1.05334112254527	JUN/PKN2/ITPR2/TRPM7/MAPK14/ANTXR2/BCL2/XIAP/TAB3/TAB2/MAVS/NFKBIA/NEK7/BIRC2/CTSB/NFKB1/ATG12/DNM1L/TP53BP1/DHX33/IKBKB/IFI16/MAPK1/NAIP/MAPK8/TYK2/TRAF5/MAP3K7/JAK1/BCL2L1/CARD8/MFN2/BRCC3/TBK1/PLCB1	0.342487540112359
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1666	18/9376	1.25063358676804	ACSL3/FASN/ACACA/ACSL1	0.494743331383351
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1666	18/9376	1.25063358676804	MTR/LMBRD1/HCFC1/ABCD4	0.494743331383351
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	26/1666	138/9376	1.06031978008595	MT-ND3/MT-CO2/MT-ND4/MT-CO3/MT-CYB/MT-CO1/MT-ND1/MT-ND6/MT-ND2/MT-ND4L/MT-ATP6/MT-ND5/COX6A1/ATP6V1B1/ATP6V0A1/ATP6AP1/ATP6V1A/NDUFB9/ATP6V1H/NDUFC1/TCIRG1/ATP6V0B/MT-ATP8/NDUFS1/NDUFB7/COX15	0.331822828868872
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	13/1666	67/9376	1.09197111680493	GNAQ/ITPR2/EP300/CAMK2G/KRAS/CREBBP/PPP3CA/BRAF/RPS6KA3/MAPK1/HRAS/PLCB1/PPP1CB	0.351182846007508
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	25/1666	133/9376	1.05786675572485	FOS/GNAQ/KIF5B/CREB3L2/ITPR2/MAPK14/CAMK2G/PPP3CA/CLOCK/ATF6B/GNG12/CREB1/PPP2R5E/GNB4/GSK3B/PPP2R3A/AKT3/MAOA/PPP2R2A/ATF2/MAPK8/AKT2/PLCB1/PPP2R3B/PPP1CB	0.312424027169878
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	17/1666	89/9376	1.07498280210961	EGFR/GJA1/ADRB1/GNAQ/ITPR2/MAP3K2/ADCY7/KRAS/TJP1/PDGFD/SOS1/SOS2/GNA11/MAPK1/ADCY6/HRAS/PLCB1	0.330380871342622
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1666	13/9376	1.29873487856681	PRKDC/RAD50/POLL	0.501009595228468
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	15/1666	79/9376	1.06857933046636	CLTC/SLC6A4/ATP6V1B1/SLC1A3/ATP6V0A1/AP2A2/VAMP2/AP2A1/AP2B1/ATP6V1A/ATP6V1H/TCIRG1/ATP6V0B/STX2/SYT1	0.284532132424646
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/1666	30/9376	1.12557022809124	IDH1/PC/OGDH/CS/ACLY/ACO1	0.320206666821811
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	8/1666	41/9376	1.09811729569877	RAD50/ATM/TOPBP1/RBBP8/TOP3A/RAD51D/BRCA2/BRCC3	0.292668704145792
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/1666	53/9376	1.06185870574645	ATP2B1/CLTC/ATP2B4/GNAQ/AP2A2/ATP1A1/AP2A1/AP2B1/ADCY6/PLCB1	0.209921475136719
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	28/1666	154/9376	1.02324566190112	EGFR/JUN/FOS/ROCK1/GNAQ/ITPR2/PPP1R12A/NFATC3/ADCY7/ROCK2/CAMK2G/KRAS/PPP3CA/PPP1R12B/CDKN1A/NFATC2/RGS2/PRKAB2/RCAN1/CCND1/MAPK1/MYLK3/PRKAA1/ADCY6/CAMKK2/HRAS/PLCB1/PPP1CB	0.135202793861829
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	11/1666	59/9376	1.04926038211895	CANT1/ENTPD4/TYMP/NME3/RRM2B/NT5C/TK2/NT5C3A/DPYD/AK9/ENTPD6	0.176433757017931
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	86/1666	480/9376	1.00832332933173	MT-ND3/MT-CO2/MT-ND4/MT-CO3/MT-CYB/MT-CO1/MT-ND1/APP/MT-ND6/MT-ND2/MT-ND4L/HSPA5/LRP5/FUS/MT-ATP6/MT-ND5/COX6A1/GNAQ/RB1CC1/KIF5B/ATP2A2/ITPR2/ATF6/MAPK14/FZD5/C9orf72/PSMD1/DVL3/ATXN2/CAMK2G/BCL2/KRAS/SPG11/UBE2G2/XBP1/GPX8/PPP3CA/UBA1/FZD3/CAT/FZD6/APC/CSNK1A1/HTT/BRAF/NFKB1/PSEN1/GSK3B/DDIT3/DCTN4/NDUFB9/ATG2A/ALS2/ULK2/FZD10/GPR37/MTOR/ERN1/DNAH14/NDUFC1/ATXN1/DCTN5/DCTN1/ATG14/PIK3R4/MAPK1/MAP2K7/MT-ATP8/NDUFS1/TARDBP/LRP6/MAPK8/CSNK1E/NDUFB7/ATG13/BCL2L1/WIPI1/HRAS/MFN2/WIPI2/PSEN2/TBK1/KLC1/PLCB1/DERL1/WNT4	0.0870194347870708
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	9/1666	48/9376	1.05522208883553	PIK3R1/ATP1A1/PIK3CA/PIK3R3/PIK3CB/AKT3/G6PC3/AKT2/PLCB1	0.178293342954672
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	20/1666	110/9376	1.02324566190112	IGF1R/MAPK14/ADCY7/PIK3R1/KRAS/PDE3B/CPEB4/PIK3CA/BRAF/RPS6KA3/PIK3R3/PIK3CB/ANAPC5/ANAPC1/AKT3/ANAPC4/MAPK1/MAPK8/AKT2/ADCY6	0.113995592246005
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	19/1666	105/9376	1.01837306351112	ITGA6/ITGB4/DAG1/ITGAV/ITGB1/ADRB1/ITGB8/ITGB5/ATP2A2/DMD/SSPN/ADCY7/ITGB6/ITGA3/SNTB1/SNTB2/ADCY6/SGCE/TTN	0.0880053111975504
Organismal Systems	Nervous system	hsa04730	Long-term depression	11/1666	60/9376	1.03177270908363	IGF1R/GNAQ/GNA12/ITPR2/KRAS/BRAF/GNA11/MAPK1/GNA13/HRAS/PLCB1	0.114765427633698
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	15/1666	83/9376	1.01708153140774	SLC27A2/IDH1/ACSL3/FAR1/CAT/ABCD3/PEX1/PEX26/ABCD4/ACOX1/MVK/GNPAT/PEX11A/ACSL1/CRAT	0.0726580652386687
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	24/1666	134/9376	1.00797333858917	MYH10/ROCK1/GNAQ/GNA12/ITPR2/PPP1R12A/ADCY7/ROCK2/PPP1R12B/CALD1/ARHGEF12/BRAF/PRKCH/EDN1/GNA11/MAPK1/MYLK3/ADCY6/GNA13/ADM/PLCB1/ARHGEF11/MYH9/PPP1CB	0.0432121198227292
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	13/1666	72/9376	1.01613978924903	MAPK14/ADAR/MAP3K1/MAVS/NFKBIA/NFKB1/CYLD/ATG12/IKBKB/DDX3X/MAPK8/MAP3K7/TBK1	0.0639035823091773
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	5/1666	27/9376	1.04219465564003	HACD3/ACOX1/ELOVL4/HACD2/HSD17B12	0.102059326196551
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	40/1666	226/9376	0.996079847868351	ATP2B1/JUN/FOS/ADRB1/ATP2B4/ROCK1/SLC9A1/GLI3/CREB3L2/ATP2A2/PPP1R12A/EP300/ADCY7/PIK3R1/ROCK2/PDE4B/ATP1A1/CAMK2G/CREBBP/PDE3B/PIK3CA/NFKBIA/PDE10A/BRAF/NFKB1/CREB1/VAV3/PIK3R3/PIK3CB/AKT3/ACOX1/PPARA/EDN1/MAPK1/TIAM1/MAPK8/AKT2/ADCY6/RAC3/PPP1CB	-0.0277295321023795
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/1666	33/9376	1.02324566190112	STX16/VAMP2/GOSR1/STX17/STX2/BET1L	0.0621801349267991
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	57/1666	323/9376	0.993150201256974	EGFR/MET/CDK6/DICER1/ROCK1/RPS6KA5/SOX4/DNMT3A/ERBB3/MDM4/NOTCH3/FOXP1/ST14/BMPR2/ABCB1/EP300/EFNA5/PIK3R1/ATM/RDX/BCL2/KRAS/CREBBP/MCL1/IRS2/FZD3/PIK3CA/APC/TP63/CDKN1A/BMI1/NFKB1/MDM2/PIK3R3/SOS1/PTEN/PIK3CB/ERBB2/SOS2/IKBKB/MTOR/NOTCH2/SOCS1/PLCG2/CCND1/SHC1/CRK/MAPK1/DNMT1/CRKL/BCL2L2/HDAC2/E2F3/HRAS/ABL1/RPTOR/SPRY2	-0.0582342866888305
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	10/1666	56/9376	1.0049734179386	CLK1/NFKBIA/CLK4/NFKB1/HSPA1A/HSPA1B/NAIP/SAR1B/RAB1B/BCL2L13	0.0173514974804059
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	8/1666	45/9376	1.00050686941443	ABCA1/ABCB1/ABCA5/ABCD3/ABCB8/ABCD4/ABCC10/ABCB10	0.00158428822962109
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	15/1666	86/9376	0.981601943102823	SLC2A1/GNAQ/KCNN4/CREB3L2/ADCY7/ATP1A1/CAMK2G/VAMP2/PCLO/ATF6B/CREB1/ATF2/GNA11/ADCY6/PLCB1	-0.079672652095818
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/1666	34/9376	0.993150201256974	POLR2J3/POLR2A/POLR2B/POLR2L/POLR3B/POLR2J2	-0.0185991581053875
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	27/1666	155/9376	0.980335359950432	ITGAV/ITGB1/DYNC1H1/COLEC12/EEA1/ITGB5/TFRC/CTSL/CANX/ATP6V1B1/ATP6V0A1/SEC61A1/ATP6AP1/DYNC1LI2/PLA2R1/RAB5B/LAMP2/PIKFYVE/OLR1/HGS/ATP6V1A/LAMP1/DYNC1LI1/ATP6V1H/TCIRG1/ATP6V0B/SEC61A2	-0.11475160987968
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/1666	69/9376	0.978756720079336	JUN/FOS/FOSB/CREB3L2/CAMK2G/PPP3CA/ATF6B/CREB1/MAOA/ATF2/HDAC2/PPP1CB	-0.0823260366244937
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	17/1666	98/9376	0.976259891711787	ATP2B1/ATP2B4/GNAQ/CREB3L2/ITPR2/ADCY7/ATP1A1/CAMK2G/LDLR/ATF6B/CREB1/ATF2/NR4A1/PRKD2/GNA11/ADCY6/PLCB1	-0.109815715887655
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/1666	17/9376	0.993150201256974	CSAD/GGT7/ADO	-0.0131396408973729
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	13/1666	76/9376	0.96265874770961	SLC27A2/SORBS1/ACSL3/CPT2/RXRA/SLC27A6/OLR1/CPT1A/PDPK1/ACOX1/PPARA/HMGCS1/ACSL1	-0.15193231249487
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	26/1666	154/9376	0.950156686051044	ATP2B1/ADRB1/ATP2B4/GNAQ/RPS6KA5/SLC9A1/CREB3L2/ATP2A2/MAPK14/ADCY7/ATP1A1/CAMK2G/BCL2/ATF6B/CREB1/PPP2R5E/PPP2R3A/AKT3/PPP2R2A/ATF2/MAPK1/AKT2/ADCY6/PLCB1/PPP2R3B/PPP1CB	-0.289901631104136
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1666	12/9376	0.93797519007603	CD46/NPC1	-0.0999358499020744
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/1666	49/9376	0.918832839258152	JUN/FOSB/CREB3L2/ATF6B/NFKB1/CREB1/MAOA/ATF2	-0.264791081722622
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1666	61/9376	0.922598547615768	ATP2B1/SLC40A1/ATP2B4/TRPM7/SLC11A2/TRPV6/ATP1A1/ATP7B/SLC46A1/ATP7A	-0.281915234577027
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/1666	43/9376	0.916161813562634	HADHA/ACSL3/CPT2/CPT1A/ACOX1/ACSL1/ACADSB	-0.256130571064641
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	6/1666	37/9376	0.912624509263165	RIMKLB/GFPT1/PPAT/ALDH4A1/GLUD1/ALDH5A1	-0.247534792343424
NA	NA	hsa04981	Folate transport and metabolism	5/1666	31/9376	0.907717925880029	MTR/SLC19A1/FOLR1/SLC46A1/MTHFR	-0.239223857360142
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	29/1666	173/9376	0.943397011983984	CDK6/ADAR/PABPN1/EP300/XPO1/PIK3R1/KPNA6/CREBBP/TLR3/DNAJC3/PIK3CA/MAVS/NFKBIA/DNAJB1/NFKB1/PIK3R3/PIK3CB/IKBKB/AKT3/NUP98/EIF2AK2/MAPK1/AKT2/TYK2/JAK1/NXF1/TBK1/KPNA5/HNRNPUL1	-0.34929602713287
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	30/1666	181/9376	0.932793006705445	EEA1/CTSD/MAPK14/CD74/EP300/ATP6V0A1/IL10RB/CAMK2G/BCL2/CREBBP/ATP6AP1/PPP3CA/PLA2R1/RAB5B/LAMP2/ARHGEF12/NFKB1/CREB1/KSR1/LAMP1/AKT3/MALT1/ATP6V1H/TCIRG1/ATP6V0B/MAPK1/MAPK8/AKT2/JAK1/NFYC	-0.424398494603105
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/1666	32/9376	0.879351740696279	ACSS1/HADHA/DBT/ACACA/ACOX1	-0.317779284113673
Organismal Systems	Digestive system	hsa04970	Salivary secretion	15/1666	93/9376	0.907717925880029	ATP2B1/ADRB1/ATP2B4/GNAQ/SLC9A1/KCNN4/ITPR2/TRPV6/SLC4A2/ADCY7/ATP1A1/VAMP2/SLC12A2/ADCY6/PLCB1	-0.415729261550466
Organismal Systems	Endocrine system	hsa04924	Renin secretion	11/1666	69/9376	0.897193660072725	ADRB1/GNAQ/ITPR2/PPP3CA/PDE3B/CTSB/CREB1/EDN1/ADCY6/CLCA2/PLCB1	-0.398414865204041
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	16/1666	99/9376	0.909551699467666	GNAQ/ITPR2/MAPK14/ADCY7/PIK3R1/CAMK2G/PIK3CA/PIK3R3/PIK3CB/TRPV4/PRKCH/PLCG2/MAPK8/ADCY6/PLCB1/PPP1CB	-0.420542776683498
Genetic Information Processing	Transcription	hsa03040	Spliceosome	40/1666	243/9376	0.926395249457808	SF1/RBM25/FUS/PRPF38B/TRA2B/TCERG1/THOC2/SF3B1/PRPF40A/DDX46/DDX5/DDX39B/TRA2A/SRSF2/SRSF6/SRSF7/SRSF5/SNRNP200/PRPF8/U2SURP/AQR/RBMXL1/U2AF1/HSPA1A/SRSF10/HSPA1B/SRSF8/SF3B3/HNRNPU/DHX15/CHERP/CDC40/NCBP1/CASC3/PRPF40B/DDX42/PRPF6/SF3A1/SRSF4/EFTUD2	-0.540378673429177
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	24/1666	149/9376	0.9064995125567	MT-ND3/MT-ND4/MT-ND1/MT-ND6/MT-ND2/MT-ND4L/MT-ND5/GABRE/GNAQ/ITPR2/MAPK14/ADCY7/GNG12/GNB4/NDUFB9/NDUFC1/NAPEPLD/MAPK1/NDUFS1/MAPK8/NDUFB7/ADCY6/GABRA4/PLCB1	-0.534776970423813
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	9/1666	59/9376	0.858485767188231	IDH1/GCLM/GPX8/GSR/GGT7/RRM2B/PGD/GCLC/LANCL1	-0.50685534079294
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/1666	28/9376	0.803978734350883	ATP6V1B1/ATP6V0A1/ATP6V1A/TCIRG1	-0.482857298769461
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/1666	103/9376	0.874229303371834	COL14A1/COL4A2/MME/SLC38A2/SLC1A5/COL4A1/KCNN4/DPP4/COL21A1/ATP1A1/COL5A2/SLC3A2/KCNK5/SLC7A8/COL8A1/PRCP	-0.596600889583442
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/1666	48/9376	0.820728291316527	HADHA/MCCC2/BCAT1/DBT/HMGCS1/BCAT2/ACADSB	-0.578807374229658
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1666	16/9376	0.703481392557023	HEXA/B3GALNT1	-0.551785096937535
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	12/1666	82/9376	0.823587971774075	HSPA5/LGMN/CTSL/CANX/PDIA3/CD74/TAPBP/CTSB/CREB1/HSPA1A/HSPA1B/NFYC	-0.745812628767257
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	21/1666	138/9376	0.856412130069419	IGF1R/ITPR2/MAPK14/SLK/FBXW11/ADCY7/CAMK2G/PPP3CA/CPEB4/SMC3/SMC1A/PPP2R5E/RPS6KA3/ANAPC5/ANAPC1/ANAPC4/MAPK1/CUL1/YWHAG/ADCY6/PPP1CB	-0.789885724446148
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/1666	44/9376	0.767434246425843	PARP1/TDG/PNKP/RFC1/NEIL1/POLL	-0.718754677565803
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	12/1666	83/9376	0.813665225126195	ADAR/MAVS/NFKBIA/NFKB1/IKBKB/IFI16/POLR2L/POLR3B/ZCCHC3/G3BP1/TBK1/DNASE2	-0.792594288289389
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1666	31/9376	0.726174340704024	HADHA/CSAD/ACOX1/DPYD	-0.70984133251933
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/1666	38/9376	0.740506729007392	HEXA/UXS1/GFPT1/GNE/NAGK	-0.745052560730602
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	42/1666	268/9376	0.881976671265521	MT-ND3/MT-CO2/MT-ND4/MT-CO3/MT-CYB/MT-CO1/MT-ND1/SLC39A10/MT-ND6/MT-ND2/MT-ND4L/HSPA5/MT-ATP6/MT-ND5/COX6A1/KIF5B/DUSP1/ITPR2/ATF6/SLC11A2/PSMD1/CAMK2G/UBE2G2/XBP1/UBA1/SLC39A7/DDIT3/NDUFB9/NFE2L2/GPR37/MAOA/ERN1/NDUFC1/MT-ATP8/NDUFS1/MAPK8/SLC39A9/NDUFB7/SLC39A8/BCL2L1/MFN2/KLC1	-0.911212551046063
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	11/1666	78/9376	0.793671314679718	ITGB1/JUN/FOS/MAPK14/TAB2/NFKBIA/NFKB1/MAPK1/MAP3K7/JAK1/PTPN6	-0.850566138243465
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/1666	32/9376	0.703481392557023	GAA/GLB1/B4GALT1/G6PC3	-0.78100978284654
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	12/1666	85/9376	0.794520161005579	CANT1/AK3/ENTPD4/TYMP/NME3/RRM2B/NT5C/TK2/NT5C3A/LACC1/AK9/ENTPD6	-0.884592794108405
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1666	10/9376	0.562785114045618	SUOX	-0.643004202019035
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	10/1666	75/9376	0.750380152060824	MTR/IDH1/PC/MAT2A/BCAT1/ALDH18A1/CS/BCAT2/ACO1/MAT2B	-1.0088831566131
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1666	27/9376	0.62531679338402	HADHA/HMGCS1/ALDH5A1	-0.906273911336495
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/1666	42/9376	0.669982278625736	HADHA/CAT/AOC1/DHTKD1/MAOA	-0.996377601334796
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/1666	76/9376	0.740506729007392	GNAQ/SLC9A1/ITPR2/SLC4A2/ADCY7/ATP1A1/CAMK2G/MYLK3/ADCY6/PLCB1	-1.05581388733745
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1666	20/9376	0.562785114045618	GNE/NPL	-0.909831102410243
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/1666	50/9376	0.675342136854742	AOC1/ALDH18A1/OAT/AMD1/MAOA/ALDH4A1	-1.06993937457144
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/1666	36/9376	0.62531679338402	MCM6/MCM2/RFC1/MCM3	-1.04697904223633
Cellular Processes	Cell motility	hsa04814	Motor proteins	28/1666	194/9376	0.812267174911202	MYH10/DYNC1H1/KIF5B/MYO1C/HOOK3/MYO7A/DYNC1LI2/MYO6/DYNLL2/MYO9A/DCTN4/KIFC3/MYO5B/KIF13B/KIF21A/MYO9B/KIF3A/KIF16B/DYNC1LI1/DNAH14/KIF3B/DCTN5/DCTN1/KIF1B/MYO1D/KIF26B/KLC1/MYH9	-1.22819799513632
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	41/1666	275/9376	0.839061442758922	MT-ND3/MT-CO2/MT-ND4/MT-CO3/MT-CYB/LAMC1/MT-CO1/MT-ND1/MT-ND6/MT-ND2/MT-ND4L/HSPA5/MT-ATP6/MT-ND5/COX6A1/KIF5B/CREB3L2/ITPR2/EGR1/MAPK14/PSMD1/PIK3R1/PPP3CA/PIK3CA/ATF6B/CREB1/GSK3B/DDIT3/NDUFB9/HSPA1A/PIK3R3/PIK3CB/HSPA1B/ATF2/NDUFC1/MAPK1/MT-ATP8/NDUFS1/MAPK8/NDUFB7/KLC1	-1.25915107660675
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/1666	37/9376	0.608416339508776	UXS1/GFPT1/GNE/NAGK	-1.10935663156063
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1666	22/9376	0.511622830950562	AOC1/MAOA	-1.06601657753791
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	18/1666	133/9376	0.761664064121889	PIK3R1/KRAS/PPP3CA/PIK3CA/PTPN11/BRAF/NFATC2/VAV3/PIK3R3/SOS1/PIK3CB/SOS2/PLCG2/SHC1/MAPK1/HRAS/PTPN6/RAC3	-1.28678153757926
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	22/1666	160/9376	0.773829531812725	ITGA6/CDH1/ITGAV/ITGB1/GLG1/PTPRF/ITGB8/CADM1/CLDN4/PTPRM/NRCAM/JAM3/NLGN4X/F11R/OCLN/CDH3/CNTNAP2/ALCAM/NRXN3/CD276/CD99L2/LRRC4	-1.34128356475289
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	12/1666	95/9376	0.710886459847097	JUN/FOS/FLT1/CTSL/ATP6V1B1/ATP6V0A1/ATP6AP1/ATP6V1A/ATP6V1H/TCIRG1/ATP6V0B/ANGPT1	-1.31652404547314
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/1666	102/9376	0.717275145352259	ATP2B1/ATP2B4/GNAQ/SLC9A1/ATP2A2/ITPR2/SLC4A2/ADCY7/ATP1A1/SLC12A2/ADCY6/CLCA2/PLCB1	-1.33452427273572
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1666	23/9376	0.489378360039668	ATP1A1/GLUD1	-1.13968180453067
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	8/1666	68/9376	0.662100134171316	RDH10/DHRS3/RDH11/ALDH1A3/DHRS4L2/RETSAT/CYP2S1/DGAT1	-1.29990087498006
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	15/1666	116/9376	0.727739371610713	GLDC/ACSS1/IDH1/CAT/PC/OGDH/CS/ACOX1/H6PD/AMT/PGD/GLUD1/ADPGK/ACO1/PGP	-1.37152677878466
Organismal Systems	Digestive system	hsa04976	Bile secretion	11/1666	90/9376	0.687848472722422	SLC2A1/SLC9A1/ABCB1/HMGCR/NCEH1/SLC4A2/ADCY7/ATP1A1/RXRA/LDLR/ADCY6	-1.3831469612088
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1666	16/9376	0.351740696278511	MAOA	-1.20633179087558
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	33/1666	238/9376	0.780332300987622	EGFR/RPS21/IL6ST/JUN/FOS/NRP1/MAPK14/ADAR/RPS27/PIK3R1/RPS29/ADAM17/TLR3/TAB2/PIK3CA/MAVS/NFKBIA/RPS28/RPL36/NFKB1/PIK3R3/PIK3CB/IKBKB/PLCG2/EIF2AK2/MAPK1/RPL39/MAPK8/CFD/TYK2/MAP3K7/JAK1/TBK1	-1.59560375711804
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	20/1666	154/9376	0.730889758500803	GUSB/GCLM/AK3/MAT2A/DHRS3/PANK3/BCAT1/MOCS1/RDH11/NME3/GGCX/COQ4/GCLC/MTHFD2L/BCAT2/VKORC1L1/ALAD/MAT2B/AK9/COX15	-1.56521490600203
NA	NA	hsa04081	Hormone signaling	30/1666	219/9376	0.770938512391258	ITGAV/IGF1R/SLC40A1/ADRB1/PRLR/GNAQ/GNA12/SMAD5/SLC16A2/ADCY7/PIK3R1/IRS2/PIK3CA/INSR/APPL1/BMPR1A/GHR/GNG12/GNB4/PIK3R3/PIK3CB/THRB/SMAD4/GNA11/ACVR1/STAT5B/ADCY6/GNA13/ADIPOR2/PLCB1	-1.59438600970321
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	16/1666	128/9376	0.703481392557023	PDE7A/ADCY7/PDE4B/CANT1/AK3/PDE3B/ENTPD4/PDE10A/PPAT/NME3/RRM2B/NT5C/ADCY6/LACC1/AK9/ENTPD6	-1.57010600229893
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1666	43/9376	0.523521036321505	PLPP3/ABCA1/AGPAT1/DGAT1	-1.4556711476391
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/1666	51/9376	0.55175011180943	PLPP3/PLD3/CHPT1/PAFAH1B2/CEPT1	-1.49202742305721
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1666	17/9376	0.331050067085658	MTR	-1.28321462083311
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1666	17/9376	0.331050067085658	GLUD1	-1.28321462083311
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	14/1666	116/9376	0.679223413503332	SLC38A2/SLC38A1/GNAQ/ITPR2/SLC1A3/ADCY7/HOMER1/SHANK2/PPP3CA/GNG12/GNB4/MAPK1/ADCY6/PLCB1	-1.61592838814084
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/1666	52/9376	0.541139532736171	IGF1R/ADCY7/LDLR/INSR/ADCY6	-1.54232937483826
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/1666	36/9376	0.468987595038015	AGL/GAA/G6PC3	-1.48381045466103
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	11/1666	97/9376	0.638209923144516	FOS/GNAQ/RPS6KA5/ADCY7/CAMK2G/GNG12/CREB1/GNB4/MAPK1/ADCY6/PLCB1	-1.66489894605008
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1666	28/9376	0.401989367175442	MOCS1/CBR1	-1.47307384147779
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/1666	37/9376	0.456312254631582	GNAQ/APOL1/PLCB1	-1.54026755116924
Human Diseases	Substance dependence	hsa05032	Morphine addiction	10/1666	91/9376	0.61844518026991	GABRE/PDE7A/ADCY7/PDE4B/PDE3B/PDE10A/GNG12/GNB4/ADCY6/GABRA4	-1.70013196839661
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/1666	38/9376	0.444304037404435	SIRT7/NT5C/NNT	-1.59550457064174
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/1666	47/9376	0.478966054506909	ACSS1/PC/ACACA/HAGH	-1.66453659941453
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	13/1666	115/9376	0.636191868051568	APP/GNAQ/SLC6A4/DUSP1/ITPR2/KRAS/GNG12/BRAF/GNB4/MAOA/MAPK1/HRAS/PLCB1	-1.82468679066432
NA	NA	hsa04382	Cornified envelope formation	28/1666	217/9376	0.726174340704024	ITGA6/ITGB4/LAMA5/COL4A2/DST/PLEC/DSP/DSG2/COL4A1/CLDN4/ST14/FURIN/SPTLC3/PRSS8/TJP1/PKP2/OCLN/KRT80/PPP2R5E/PPP2R3A/KDSR/PPP2R2A/PCSK6/GBA2/JUP/UGCG/ELOVL4/PPP2R3B	-1.89703754877793
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/1666	87/9376	0.582191497288571	MT-CO2/MT-CO3/MT-CYB/MT-CO1/COX6A1/ASPH/SLC9A1/ATP2A2/ATP1A1	-1.81990352642158
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/1666	31/9376	0.363087170352012	H6PD/PGD	-1.65107628283771
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/1666	41/9376	0.411793985887038	GLDC/MAOA/AMT	-1.7545274836123
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	9/1666	89/9376	0.569108542293322	GABRE/SLC38A2/SLC38A1/ADCY7/TRAK2/GNG12/GNB4/ADCY6/GABRA4	-1.89854594981832
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/1666	23/9376	0.244689180019834	GLUD1	-1.68581574091417
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	32/1666	254/9376	0.709020616120464	EGFR/ATP2B1/MET/ADRB1/ATP2B4/ASPH/GNAQ/PHKB/FLT1/MCOLN3/ERBB3/ATP2A2/ITPR2/NFATC3/FGFR2/ADCY7/STIM2/CAMK2G/PPP3CA/PDGFD/STIM1/NFATC2/TPCN1/ERBB2/P2RX4/PLCG2/GNA11/PHKA2/MYLK3/EDNRB/ORAI3/PLCB1	-2.18539523611256
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/1666	78/9376	0.505063563887093	ITGB1/JUN/FOS/MAPK14/NFKB1/MAPK1/MAPK8	-2.04031820629818
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/1666	35/9376	0.321591493740353	ENOSF1/PFKFB4	-1.86906570391363
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	19/1666	168/9376	0.636483164694449	TRPM7/CFLAR/PARP1/CAMK2G/BCL2/XIAP/TLR3/SMPD1/BIRC2/CYLD/DNM1L/CHMP4C/EIF2AK2/MAPK8/STAT5B/TYK2/TRAF5/GLUD1/JAK1	-2.21000095881371
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/1666	46/9376	0.367033770029751	GUSB/ALAD/COX15	-2.00038957159402
Human Diseases	Substance dependence	hsa05034	Alcoholism	22/1666	191/9376	0.648234162775058	FOSB/CREB3L2/KRAS/SLC29A3/SLC29A1/ATF6B/GNG12/BRAF/CREB1/GNB4/SOS1/SOS2/MAOA/ATF2/SHC1/MAPK1/HDAC6/CAMKK2/HDAC2/HRAS/HDAC7/PPP1CB	-2.28310933833623
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1666	26/9376	0.216455813094469	ACOX1	-1.8596889441526
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1666	26/9376	0.216455813094469	HES1	-1.8596889441526
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/1666	82/9376	0.480426316868211	GUSB/TYMP/NME3/RRM2B/TK2/CES2/DPYD	-2.19658839792116
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/1666	66/9376	0.426352359125468	JUN/GATA3/SMAD2/NFKB1/IL4R	-2.17389361455407
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1666	29/9376	0.194063832429524	SLC24A1	-2.02050286748586
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1666	41/9376	0.274529323924692	GABRE/GABRA4	-2.16396672116392
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1666	31/9376	0.181543585176006	GUSB	-2.12169375799689
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/1666	46/9376	0.244689180019834	PSMD1/PSME4	-2.38704028123502
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/1666	67/9376	0.335991112863056	ACSS1/MINPP1/G6PC3/ADPGK	-2.53545394315064
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	18/1666	183/9376	0.553559128569461	XRN1/XPO1/UTP14C/REXO1/WDR43/XRN2/LSG1/MPHOSPH10/MDN1/NOP56/GTPBP4/HEATR1/WDR36/BMS1/TBL3/NXF1/TCOF1/NVL	-2.83502445643439
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/1666	36/9376	0.156329198346005	GUSB	-2.35747327951043
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/1666	37/9376	0.152104084877194	MAOA	-2.40208939038645
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/1666	50/9376	0.225114045618247	LRP1/MET	-2.5537068018724
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/1666	38/9376	0.148101345801478	BLNK	-2.44595658055289
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/1666	100/9376	0.393949579831933	CSF3R/ITGA6/MME/TFRC/IL4R/CD55/ITGA3	-2.83220271247603
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	18/1666	195/9376	0.519493951426724	MAPK14/PIK3R1/CLCN3/PIK3CA/CLCN5/NFKB1/PIK3R3/PIK3CB/AKT3/MTOR/PLCG2/MAPK1/AKT2/MAP3K7/HDAC6/HDAC2/PLCB1/HDAC7	-3.15186145105114
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/1666	88/9376	0.319764269344101	F5/CD46/TFPI/CD55/CFD	-2.98013282269407
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/1666	63/9376	0.178661940966863	CBR1/PTGES2	-3.04048852377748
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1666	86/9376	0.261760518160753	KCNK5/ADCY6/GABRA4/PLCB1	-3.1969407274199
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/1666	50/9376	0.112557022809124	LTBR	-2.92464865869764
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/1666	66/9376	0.170540943650187	STS/HSD17B12	-3.14331589228533
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/1666	79/9376	0.142477244062182	CBR1/CYP2S1	-3.55781802899517
NA	NA	hsa04082	Neuroactive ligand signaling	14/1666	199/9376	0.395929225961741	ADRB1/GABRE/GNAQ/SLC6A4/SLC1A3/ADCY7/GNG12/GNB4/P2RX4/GNA11/GLRB/ADCY6/GABRA4/PLCB1	-4.00368540067035
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/1666	70/9376	0.0803978734350883	CBR1	-3.58974343983584
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/1666	100/9376	0.168835534213685	IL6ST/IL10RB/LTBR	-3.8842086007644
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/1666	73/9376	0.0770938512391258	MAOA	-3.679623694032
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/1666	99/9376	0.0568469812167291	CFD	-4.38522544947926
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	18/1666	298/9376	0.339937317208763	CSF3R/IL6ST/PRLR/BMP7/LIFR/BMPR2/IL10RB/TGFBR1/BMPR1A/ACVR2B/GHR/TGFBR2/LTBR/IL4R/ACVR2A/TNFRSF21/ACVR1/BMP4	-5.38262557759501
Genetic Information Processing	Translation	hsa03010	Ribosome	9/1666	222/9376	0.228156127315791	RPS21/RPS27/RPS29/RPS28/RPL36/MRPS5/MRPS26/RPL39/MRPL1	-5.40998974324032
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/1666	143/9376	0.0393556023808125	ACTN4	-5.38090349292234
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	15/1666	370/9376	0.228156127315791	ADRB1/PRLR/GABRE/NR3C1/GHR/S1PR3/S1PR2/THRB/P2RX4/APELA/EDN1/GLRB/EDNRB/GABRA4/ADM	-7.04142080730455
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/1666	449/9376	0.0250683792447937	CAMK2G/RGS2	-9.84102890174226