category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	80/826	222/9376	4.09048273455053	RPS21/RPS29/RPS5/RPSA/RPS7/RPL37A/RPS17/RPS18/RPL18/RPS3/RPS16/RPS23/RPLP0/RPS27/RPS14/RPL5/RPL27A/RPS12/RPS4Y1/MRPS26/RPLP1/RPL37/RPL7A/RPL23/RPS19/RPL23A/RPL3/RPL10A/MRPL12/RPL13A/RPL36/RPL35/RPLP2/RPS27A/RPS15A/RPS2/RPL21/MRPS15/RPL31/RPS6/RPL14/MRPL20/MRPL51/MRPL11/MRPS34/MRPL14/RPS8/RPL15/RPL7/MRPL27/MRPL1/MRPL16/RPL8/RPS25/MRPS33/RPS20/MRPL19/MRPS25/MRPL37/MRPL43/MRPS10/MRPS6/MRPL17/MRPS7/MRPL36/MRPL2/RPL27/RPL6/RPL34/MRPL3/RPS28/MRPS31/MRPL4/MRPS5/RPS4X/MRPS21/MRPL55/MRPL46/RPS15/MRPS16	14.4840481321763
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	77/826	268/9376	3.26132051606375	TUBB/TUBA1B/GNAS/SOD1/TUBB4B/PSMD7/COX6A1/SLC25A5/SLC39A10/MT-ND3/TUBA1C/UQCRQ/PSMC3/HSPA5/UBB/PSMA3/SLC39A1/NDUFB9/NDUFA10/RPS27A/MT-ND6/PSMB6/NDUFB7/PSMB5/SLC25A4/PSMB1/PSMB2/CALM2/PSMD11/NDUFA6/MT-CO2/MT-CYB/PSMC1/PSMD14/PSMD1/NDUFB4/TXN/NDUFB11/NDUFAB1/NDUFV1/CYC1/PSMC2/PARK7/COX6C/NDUFS6/NDUFS8/SLC39A7/GNAI1/PSMD2/COX5A/VDAC1/UQCR10/CAMK2G/COX7A2/NDUFC2/NDUFV2/PSMD12/PSMA1/NDUFA11/VDAC3/PSMB7/NDUFB10/MT-CO3/TRAP1/PSMC5/NDUFA13/NDUFA4/UQCRC2/PSMD3/SLC25A6/COX4I1/ADRM1/TXN2/NDUFS7/PSMD4/PSMD6/UQCRFS1	11.6737560496585
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	77/826	308/9376	2.83777239709443	TUBB/TUBA1B/POLR2L/TGM2/SOD1/TUBB4B/TFAM/PSMD7/COX6A1/GPX8/SLC25A5/MT-ND3/TUBA1C/UQCRQ/PSMC3/PSMA3/NDUFB9/NDUFA10/MT-ND6/POLR2H/PSMB6/NDUFB7/PSMB5/SLC25A4/PSMB1/PSMB2/PSMD11/NDUFA6/MT-CO2/MT-CYB/PSMC1/PSMD14/CLTA/PSMD1/NDUFB4/NDUFB11/NDUFAB1/NDUFV1/POLR2F/CYC1/HDAC2/POLR2I/PSMC2/COX6C/NDUFS6/NDUFS8/PSMD2/COX5A/VDAC1/UQCR10/COX7A2/NDUFC2/NDUFV2/PSMD12/PSMA1/NDUFA11/VDAC3/PSMB7/NDUFB10/MT-CO3/PSMC5/NDUFA13/POLR2K/NDUFA4/AP2A2/UQCRC2/PSMD3/SLC25A6/COX4I1/ADRM1/PPARG/AP2M1/NDUFS7/RCOR1/PSMD4/PSMD6/UQCRFS1	10.1930447589454
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	23/826	36/9376	7.25208501479688	PCNA/MCM7/MCM3/MCM6/FEN1/RPA3/MCM5/MCM4/RFC3/RFC4/RFC2/LIG1/RNASEH2A/RPA2/MCM2/RFC1/POLD3/PRIM1/RPA1/POLA1/POLE3/POLD2/POLE2	11.6814106544128
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	69/826	275/9376	2.8480915694475	TUBB/TUBA1B/SOD1/TUBB4B/PSMD7/COX6A1/LAMC1/SLC25A5/MT-ND3/TUBA1C/UQCRQ/PSMC3/HSPA5/PSMA3/NDUFB9/NDUFA10/MT-ND6/HSPA8/PSMB6/NDUFB7/PSMB5/SLC25A4/PSMB1/PSMB2/PSMD11/NDUFA6/MT-CO2/MT-CYB/PSMC1/PSMD14/PSMD1/NDUFB4/NDUFB11/NDUFAB1/NDUFV1/CYC1/PSMC2/COX6C/NDUFS6/NDUFS8/PSMD2/COX5A/VDAC1/UQCR10/BAD/COX7A2/NDUFC2/NDUFV2/PSMD12/PSMA1/NDUFA11/VDAC3/PSMB7/NDUFB10/MT-CO3/PSMC5/NDUFA13/NDUFA4/UQCRC2/PSMD3/SLC25A6/COX4I1/ADRM1/MAPK14/NDUFS7/PSMD4/PSMD6/MAPK13/UQCRFS1	9.66802756811407
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	49/826	158/9376	3.52027461918043	PCNA/MCM7/MCM3/ORC6/MCM6/MCM5/PRKDC/CDK1/SMC3/TFDP2/CDC6/MCM4/CCND1/MAD2L1/ANAPC11/CCNE1/CDKN1C/WEE1/CDT1/CHEK1/CCND3/MCM2/CCNA2/CDCA5/PKMYT1/CCNE2/FBXO5/ESCO2/RAD21/CDK4/CDC45/HDAC2/BUB3/CDK6/DBF4/CDKN2A/NDC80/TTK/RBL1/CDK2/YWHAE/AURKB/SKP2/CCNB2/E2F1/STAG1/TFDP1/BUB1B/CCNB1	9.93003231705599
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	76/826	368/9376	2.34424676281714	TUBB/TUBA1B/SOD1/FUS/TUBB4B/PSMD7/COX6A1/GPX8/MT-ND3/HNRNPA1/TUBA1C/UQCRQ/HNRNPA3/PSMC3/HSPA5/PSMA3/NDUFB9/NDUFA10/MT-ND6/PSMB6/NDUFB7/TOMM40/PSMB5/PSMB1/PSMB2/PSMD11/NDUFA6/MT-CO2/MT-CYB/PSMC1/HNRNPA2B1/PSMD14/PSMD1/NDUFB4/NDUFB11/NDUFAB1/NXT1/NDUFV1/CYC1/PSMC2/COX6C/NDUFS6/NDUFS8/PSMD2/COX5A/VDAC1/UQCR10/BAD/COX7A2/NDUFC2/NDUFV2/PSMD12/PSMA1/NDUFA11/TPR/PSMB7/SIGMAR1/NDUFB10/SRSF7/NUP54/MT-CO3/PSMC5/VCP/NDUFA13/NDUFA4/UQCRC2/PSMD3/COX4I1/ADRM1/MAPK14/NDUFS7/PSMD4/PSMD6/MAPK13/UQCRFS1/ALYREF	8.1767613860599
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	55/826	238/9376	2.62315095529737	EGFR/RPS21/RPS29/RPS5/RPSA/RPS7/RPL37A/RPS17/RPS18/RPL18/RPS3/RPS16/RPS23/RPLP0/RPS27/RPS14/RPL5/RPL27A/RPS12/RPS4Y1/RPLP1/RPL37/RPL7A/RPL23/RPS19/RPL23A/RPL3/RPL10A/RPL13A/RPL36/RPL35/RPLP2/RPS27A/RPS15A/RPS2/NRP1/RPL21/RPL31/RPS6/RPL14/RPS8/RPL15/IL6ST/RPL7/RPL8/RPS25/RPS20/RPL27/RPL6/RPL34/RPS28/RPS4X/MAPK14/MAPK13/RPS15	7.88341551725542
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	75/826	388/9376	2.1941539152792	TUBB/TUBA1B/APP/MME/TUBB4B/PSMD7/COX6A1/SLC25A5/SLC39A10/MT-ND3/TUBA1C/UQCRQ/PSMC3/NAE1/PSMA3/SLC39A1/NDUFB9/NDUFA10/HRAS/MT-ND6/PSMB6/NDUFB7/PSMB5/SLC25A4/PSMB1/PSMB2/CALM2/PSMD11/NDUFA6/MT-CO2/MT-CYB/PSMC1/PSMD14/PSMD1/LRP5/NDUFB4/NDUFB11/NDUFAB1/NDUFV1/CYC1/PSMC2/COX6C/NDUFS6/NDUFS8/SLC39A7/PSMD2/COX5A/VDAC1/UQCR10/BAD/COX7A2/NDUFC2/NDUFV2/PSMD12/PSMA1/NDUFA11/CAPN1/VDAC3/PSMB7/INSR/NDUFB10/MT-CO3/PSMC5/NDUFA13/NDUFA4/UQCRC2/PSMD3/BACE2/SLC25A6/COX4I1/ADRM1/NDUFS7/PSMD4/PSMD6/UQCRFS1	7.46684682541066
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	21/826	46/9376	5.18201915991157	PSMD7/PSMC3/PSMA3/PSMB6/PSMB5/PSMB1/PSMB2/PSMD11/PSMC1/PSMD14/PSMD1/PSMC2/PSMD2/PSMD12/PSMA1/PSMB7/PSMC5/PSMD3/ADRM1/PSMD4/PSMD6	8.83724136400983
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	47/826	205/9376	2.60244493001831	PARP1/SLC2A1/MPC2/COX6A1/SLC25A5/MT-ND3/UQCRQ/NDUFB9/NDUFA10/MT-ND6/NDUFB7/SLC25A4/NDUFA6/MT-CO2/MT-CYB/NDUFB4/NDUFB11/NDUFAB1/PDHA1/NDUFV1/CYC1/COX6C/NDUFS6/NDUFS8/COX5A/VDAC1/UQCR10/CAMK2G/COX7A2/NDUFC2/NDUFV2/NDUFA11/GFPT1/VDAC3/INSR/NDUFB10/MT-CO3/NDUFA13/NDUFA4/UQCRC2/SLC25A6/COX4I1/MAPK14/NDUFS7/MAPK13/UQCRFS1/CPT2	7.21015003002605
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	14/826	23/9376	6.90935887988209	PCNA/RPA3/RFC3/RFC4/RFC2/MSH2/LIG1/RPA2/MSH6/RFC1/POLD3/RPA1/POLD2/EXO1	8.81904220808024
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	82/826	480/9376	1.93914447134786	TUBB/TUBA1B/APP/SOD1/FUS/TUBB4B/PSMD7/COX6A1/GPX8/SLC25A5/MT-ND3/TUBA1C/UQCRQ/PSMC3/HSPA5/UBB/PSMA3/NDUFB9/NDUFA10/HRAS/RPS27A/MT-ND6/PSMB6/NDUFB7/TOMM40/PSMB5/SLC25A4/PSMB1/PSMB2/CALM2/PSMD11/NDUFA6/MT-CO2/MT-CYB/PSMC1/PSMD14/PSMD1/LRP5/NDUFB4/NDUFB11/NDUFAB1/NDUFV1/CYC1/PSMC2/PARK7/COX6C/NDUFS6/NDUFS8/PSMD2/COX5A/VDAC1/UQCR10/BAD/CAMK2G/COX7A2/NDUFC2/NDUFV2/PSMD12/PSMA1/NDUFA11/CAPN1/VDAC3/PSMB7/SIGMAR1/NDUFB10/MT-CO3/TRAP1/PSMC5/VCP/NDUFA13/NDUFA4/UQCRC2/PSMD3/SLC25A6/COX4I1/ADRM1/MAPK14/NDUFS7/PSMD4/PSMD6/MAPK13/UQCRFS1	6.56520425449021
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	49/826	227/9376	2.45023519749123	EGFR/MGST3/MET/SOD1/SLC26A2/COX6A1/SLC25A5/MT-ND3/UQCRQ/NDUFB9/NDUFA10/HRAS/MT-ND6/NDUFB7/SLC25A4/NDUFA6/MT-CO2/MT-CYB/NDUFB4/NDUFB11/NDUFAB1/NDUFV1/CYC1/COX6C/NDUFS6/NDUFS8/COX5A/VDAC1/UQCR10/BAD/COX7A2/NDUFC2/NDUFV2/NDUFA11/VDAC3/PTK2/NDUFB10/MT-CO3/NDUFA13/ACP1/NDUFA4/UQCRC2/SLC25A6/COX4I1/MAPK14/NDUFS7/MAPK13/UQCRFS1/GSTA4	6.87475397226771
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	35/826	138/9376	2.87889953328421	COX6A1/MT-ND3/UQCRQ/NDUFB9/NDUFA10/ATP6V1C2/MT-ND6/NDUFB7/NDUFA6/MT-CO2/MT-CYB/NDUFB4/NDUFB11/NDUFAB1/NDUFV1/CYC1/COX6C/NDUFS6/NDUFS8/ATP6V1B1/COX5A/UQCR10/COX7A2/NDUFC2/NDUFV2/NDUFA11/NDUFB10/PPA1/MT-CO3/NDUFA13/NDUFA4/UQCRC2/COX4I1/NDUFS7/UQCRFS1	6.91109284304841
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	49/826	235/9376	2.36682293544897	GNAS/COX6A1/MT-ND3/UQCRQ/NDUFB9/NDUFA10/HRAS/MT-ND6/COX20/NDUFB7/RPS6/RHEB/NDUFA6/MT-CO2/MT-CYB/NDUFB4/NDUFB11/NDUFAB1/NDUFV1/CYC1/SMARCA2/COA4/COX6C/NDUFS6/NDUFS8/SMARCC1/COX5A/UQCR10/COX7A2/NDUFC2/NDUFV2/NDUFA11/ACTL6A/NDUFB10/MT-CO3/MGLL/NDUFA13/NDUFAF6/NDUFA4/UQCRC2/COX4I1/ACSL3/PPARG/MAPK14/NDUFS7/MAPK13/SMARCA4/UQCRFS1/CPT2	6.59541213315551
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	17/826	44/9376	4.38564825005503	HMGB1/PCNA/PARP1/FEN1/UNG/RFC3/RFC4/RFC2/LIG1/RFC1/POLD3/PNKP/PARP2/POLE3/POLD2/POLE2/APEX1	6.99638037683613
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	16/826	41/9376	4.4296934979035	RPA3/RAD51/BRCA1/RAD51C/RPA2/BARD1/BLM/TOPBP1/POLD3/BRCA2/RAD50/RPA1/POLD2/BRCC3/XRCC2/RBBP8	6.84041864076621
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	20/826	63/9376	3.6035205042469	PCNA/POLR2L/RPA3/RFC3/RFC4/RFC2/LIG1/DDB1/RPA2/POLR2H/RFC1/POLD3/POLR2F/POLR2I/RPA1/POLE3/POLD2/POLE2/POLR2K/RAD23B	6.44434941650092
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	34/826	157/9376	2.45819774525377	COX6A1/UQCRQ/NDUFB9/NDUFA10/NDUFB7/NDUFA6/MT-CO2/MT-CYB/NDUFB4/NDUFB11/NDUFAB1/NDUFV1/CYC1/COX6C/NDUFS6/NDUFS8/COX5A/UQCR10/COX7A2/NDUFC2/NDUFV2/NDUFA11/INSR/NDUFB10/MT-CO3/NDUFA13/NDUFA4/UQCRC2/COX4I1/PPARG/MAPK14/NDUFS7/MAPK13/UQCRFS1	5.72686500024263
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	32/826	157/9376	2.31359787788591	CDK1/CCND1/SLC25A5/CCNE1/CHEK1/CCND3/HRAS/CCNA2/RBBP4/CCNE2/SLC25A4/CALM2/RHEB/MYBL2/CDK4/RAD50/CDK6/CDKN2A/VDAC1/RBL1/CDK2/CAPN1/VDAC3/CCNB2/FOXM1/E2F1/CCNB1/RRAS2/SLC25A6/RAD9A/MAPK14/MAPK13	5.1589695127039
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	16/826	54/9376	3.36328580396377	UBE2T/RPA3/RAD51/RMI2/BRCA1/RAD51C/RPA2/FANCI/USP1/BLM/BRCA2/FANCD2/RPA1/FANCL/FANCB/FANCA	5.41316395538527
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	19/826	75/9376	2.87560936238902	PERP/SIVA1/CDK1/CCND1/RRM2/CCNE1/CHEK1/CCND3/PMAIP1/CCNE2/GTSE1/CDK4/CDK6/CDKN2A/EI24/CDK2/SIAH1/CCNB2/CCNB1	5.06874923399724
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	28/826	144/9376	2.20715630885122	PSMD7/SLC25A5/PSMC3/PSMA3/NOP56/PSMB6/PSMB5/SLC25A4/PSMB1/PSMB2/PSMD11/PSMC1/PSMD14/PSMD1/PSMC2/PSMD2/VDAC1/AFG3L2/PSMD12/PSMA1/VDAC3/PSMB7/PSMC5/PSMD3/SLC25A6/ADRM1/PSMD4/PSMD6	4.53721606445887
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	20/826	93/9376	2.44109453513499	ITGA6/LAMB1/LAMA5/CKS1B/ITGB1/COL4A2/CCND1/LAMC1/CCNE1/CKS2/CCNE2/COL4A1/CDK4/CDK6/CDK2/SKP2/PTK2/E2F1/ITGAV/TRAF4	4.34092592355169
Genetic Information Processing	Transcription	hsa03040	Spliceosome	39/826	243/9376	1.82177981048038	SNRPG/SNRPD1/FUS/SNRPE/SRSF2/SNRPF/SNRPB/HNRNPA1/HNRNPA3/LSM2/LSM4/LSM3/HSPA8/SNRPD3/SF1/CTNNBL1/LSM7/SNU13/LSM5/SNRPA1/RBM17/MAGOH/SRSF10/MAGOHB/SNRPD2/USP39/TRA2B/SRSF7/RBMX/SNRNP70/LSM8/U2SURP/PRPF8/DDX46/SF3A3/RP9/SNRNP40/ALYREF/THOC3	4.03407975190061
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	30/826	174/9376	1.95708441178926	P4HB/LMAN1/HSP90B1/RRBP1/PDIA6/RPN2/TUSC3/DDOST/HSP90AA1/PDIA3/HSP90AB1/CALR/PDIA4/ERP29/HSPA5/HSPA8/SVIP/BAG2/SEC63/CKAP4/UBXN4/CAPN1/GANAB/VCP/DNAJC1/UBXN2A/UBE4B/SIL1/ERLEC1/RAD23B	3.96074020649704
NA	NA	hsa04518	Integrin signaling	27/826	154/9376	1.99012609666363	EGFR/FBN1/CDH1/ITGA6/LAMB1/MET/LAMA5/ITGB4/ITGB1/COL4A2/CCND1/LAMC1/FLT1/CCND3/FERMT1/FRAS1/ITGB5/COL4A1/FERMT2/IGF1R/VCL/PTK2/PDGFA/RAC3/ITGB8/ITGAV/ACTN4	3.85062222621893
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	11/826	43/9376	2.9037671040036	ECI1/ALDH7A1/ECHS1/ACADVL/ADH5/HADH/ACAT2/ECI2/ACSL3/ACADM/CPT2	3.88892902898924
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	25/826	149/9376	1.90454523294928	MT-ND3/NDUFB9/NDUFA10/MT-ND6/GNG12/NDUFB7/NDUFA6/NDUFB4/NDUFB11/NDUFAB1/NDUFV1/NDUFS6/NDUFS8/GNAI1/GABRE/NDUFC2/NDUFV2/NDUFA11/NDUFB10/MGLL/NDUFA13/NDUFA4/MAPK14/NDUFS7/MAPK13	3.45928041116802
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	13/826	59/9376	2.50108753642221	GGCT/MGST3/GSTP1/RRM1/GPX8/RRM2/IDH2/SMS/GCLM/PRDX6/SRM/IDH1/GSTA4	3.59489807584503
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	16/826	86/9376	2.11183062109353	ITGA6/DSP/DAG1/ITGB4/ITGB1/DSG2/GJA1/DSC2/ITGB5/SGCE/LMNA/DMD/ITGB8/ITGAV/PKP2/TCF7L2	3.21938268519057
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	5/826	13/9376	4.36580368783759	FEN1/PRKDC/XRCC5/RAD50/XRCC6	3.7743793796789
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	26/826	170/9376	1.73604899586953	PCNA/TUBA1B/MYH10/CLDN4/CLDN7/ARPC5L/ITGB1/CCND1/TUBA1C/AMOT/MARVELD3/PARD3/RDX/JAM3/TJP1/CDK4/ARPC1A/PARD6B/EZR/DLG1/AMOTL1/ACTN4/MARVELD2/AMOTL2/MPDZ/DLG3	3.01015115635146
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	8/826	31/9376	2.92931344216199	GCSH/PGP/ACSS1/GLDC/GRHPR/ACAT2/MDH1/SHMT1	3.34415646430401
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	18/826	106/9376	1.92754351500754	SPINT1/EGFR/GSTP1/HSP90B1/HSP90AA1/HSP90AB1/CCND1/CCNE1/HRAS/CCNE2/FOLR1/SLC19A1/BAD/IGF1R/CDK2/E2F1/PDGFA/TCF7L2	2.98496995014132
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	11/826	54/9376	2.31225899022509	LDHB/DNMT1/CDO1/CISD1/SMS/ADI1/MTAP/GCLM/SRM/MDH1/ENOPH1	3.00576132353632
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	16/826	93/9376	1.952875628108	EGFR/CDH1/MET/LMO7/PARD3/TJP1/PTPRF/YES1/IGF1R/VCL/INSR/WASF2/RAC3/ACP1/ACTN4/TCF7L2	2.87029227793659
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	29/826	205/9376	1.60576389299002	PDIA3/PSMD7/CCND1/CCNE1/CALR/PSMC3/CCND3/CCNA2/CCNE2/PSMD11/PSMC1/PSMD14/PSMD1/CDK4/HDAC2/CDK6/PSMC2/PSMD2/CDK2/PSMD12/SKP2/E2F1/PSMC5/PSMD3/ADRM1/MAPK14/PSMD4/PSMD6/MAPK13	2.72561538272693
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	32/826	233/9376	1.5589479263008	FBLN1/FBN2/SYNE2/FBN1/ITGA6/DSP/MYH10/CSRP2/PDLIM1/DAG1/DIAPH3/ITGB4/ITGB1/COL4A2/DSG2/DSC2/LMNB1/ITGB5/COL4A1/ANK3/SPTBN1/FHL2/INF2/SGCE/VCL/LMNA/DMD/ITGB8/ITGAV/DAAM1/LMNB2/PKP2	2.68532932387501
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	15/826	87/9376	1.95708441178926	COX6A1/UQCRQ/ASPH/MT-CO2/MT-CYB/CYC1/COX6C/SLC9A1/COX5A/UQCR10/COX7A2/MT-CO3/UQCRC2/COX4I1/UQCRFS1	2.78752000102312
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	28/826	203/9376	1.56566752943141	EGFR/ITGA6/LAMB1/MET/LAMA5/ITGB4/ITGB1/COL4A2/CCND1/LAMC1/FLT1/EMP2/CCND3/HRAS/ITGB5/COL4A1/VAV3/BAD/IGF1R/BCAR1/VCL/PAK6/PTK2/PDGFA/RAC3/ITGB8/ITGAV/ACTN4	2.53248088891579
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/826	23/9376	2.96115380566375	FDPS/ACAT2/PMVK/ICMT/PCYOX1/HMGCR	2.9267977356337
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	11/826	59/9376	2.1163048385111	DUT/TYMS/RRM1/DTYMK/RRM2/TK1/UMPS/NME4/DCTPP1/NME1/CTPS1	2.67339646666103
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/826	17/9376	3.33855576128757	MYH10/DAG1/NRP2/TFRC/PCDH11X	2.99950832316704
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	30/826	224/9376	1.52023521272916	SLC2A1/RANBP1/RAN/FDPS/CCND1/MAD2L1/ANAPC11/SLC25A5/CCNE1/CALR/CHEK1/CCND3/HRAS/CCNA2/NRP1/CCNE2/SLC25A4/MSX2/CDK4/BUB3/CDKN2A/NFYB/VDAC1/CDK2/DLG1/VDAC3/CCNB2/E2F1/BUB1B/SLC25A6	2.44939232413255
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/826	30/9376	2.64858757062147	TYMS/GGH/DHFR/FOLR1/SLC19A1/SHMT1/ATIC	2.81094510734412
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	14/826	85/9376	1.86959122632104	DUT/TYMS/RRM1/DTYMK/RRM2/TK1/PNP/GMPS/NME4/ADK/DCTPP1/IMPDH2/NME1/CTPS1	2.50314487817312
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	13/826	78/9376	1.89184826472962	CDH1/MET/ARPC5L/ITGB1/CLTA/ARPC1A/BCAR1/VCL/ARHGAP10/GAB1/PTK2/WASF2/CD2AP	2.45830693638059
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	9/826	47/9376	2.17361289990212	LDHB/ACSS1/ALDH7A1/ADH5/FH/GRHPR/ACAT2/PDHA1/MDH1	2.50696840933071
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	27/826	205/9376	1.49502155554243	RANBP1/CDK1/CCND1/CCNE1/CHEK1/DDB1/CCND3/HRAS/PMAIP1/CCNA2/CCNE2/PSMC1/IL6ST/SCIN/CDK4/SND1/HDAC2/CDK6/CDKN2A/RBL1/BAD/CDK2/DLG1/YWHAE/SKP2/VDAC3/ACTN4	2.22733375524925
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	14/826	89/9376	1.78556465435155	ITGA6/LAMB1/DAG1/LAMA5/ITGB4/ITGB1/COL4A2/LAMC1/FRAS1/HMMR/ITGB5/COL4A1/ITGB8/ITGAV	2.31436482287686
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	14/826	89/9376	1.78556465435155	EGFR/TUBB/TUBA1B/GNAS/CDK1/TUBB4B/TUBA1C/GJA1/HRAS/ADRB1/TJP1/GNA11/GNAI1/PDGFA	2.31436482287686
Human Diseases	Cancer: specific types	hsa05218	Melanoma	12/826	73/9376	1.86593253507579	EGFR/CDH1/MET/CCND1/HRAS/CDK4/CDK6/CDKN2A/BAD/IGF1R/E2F1/PDGFA	2.30848247258521
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	10/826	57/9376	1.99141922603118	HACD3/TECR/ECHS1/ACADVL/HADH/ACAT2/FASN/ACSL3/ACADM/CPT2	2.33347264000531
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	16/826	108/9376	1.68164290198189	RAN/CSE1L/KPNB1/UPF3A/NXT1/MAGOH/RANBP17/MAGOHB/IPO5/PNN/TPR/NUP54/RNPS1/UBE2I/ALYREF/THOC3	2.21446278612722
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	17/826	117/9376	1.64930361540531	RBBP7/MORF4L2/RBBP4/BRD7/SMARCA1/BAZ1B/SMARCA2/HDAC2/SMARCC1/POLE3/CDK2AP2/ACTL6A/ACTR6/MBD3/RUVBL1/ING3/SMARCA4	2.19660169510025
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/826	28/9376	2.43237634036665	GGH/DHFR/AKR1B1/MOCS2/QDPR/PTS	2.35922524707357
NA	NA	hsa04517	IgSF CAM signaling	36/826	299/9376	1.36668637184481	CDH1/TUBB/TUBA1B/MYH10/APP/CADM1/TUBB4B/ARPC5L/NRP2/ITGB1/TUBA1C/RASA1/CNTNAP2/DYNLL2/LMO7/NRP1/PARD3/RDX/ANK3/JAM3/TJP1/PTPRF/ARPC1A/SPTBN1/PARD6B/VAV3/EZR/BCAR1/VCL/PAK6/PTK2/CD2AP/ACTN4/MPDZ/MAPK14/MAPK13	2.00286556725737
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	12/826	78/9376	1.74632147513503	BTG3/HSPD1/LSM2/EXOSC8/LSM4/LSM3/LSM7/LSM5/LSM8/EXOSC3/LSM1/HSPA9	2.05717422083056
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/826	37/9376	2.14750343563903	CDH1/CCND1/HRAS/TPR/TFG/TCF7L2/PPARG	2.17368832781442
NA	NA	hsa04519	Cadherin signaling	46/826	404/9376	1.29245079471628	EGFR/CDH1/DSP/KRT7/KRT18/MET/ARPC5L/DSG2/KRT8/DSC3/GJA1/FAT1/HRAS/DSC2/MYO1C/LRP5/KRT23/YAP1/TJP1/TMC5/ARPC1A/TEAD1/VAV3/GABRE/RERE/IGF1R/LIMA1/YWHAE/VCL/KRT19/PTK2/MYO7A/RAC3/KRT10/AMOTL1/DAAM1/CDH3/ACTN4/RRAS2/PKP2/TCF7L2/AMOTL2/MPDZ/MAPK14/PCDH11X/MAPK13	1.86763266200751
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/826	30/9376	2.27021791767555	IDH2/FH/PDHA1/MDH1/SUCLG1/IDH1	2.16580114067276
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/826	39/9376	2.03737505432421	TYMS/GCSH/ALDH7A1/DHFR/GLDC/SHMT1/ATIC	2.01770202073204
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	28/826	232/9376	1.36995908825248	EGFR/ITGA6/MYH10/DIAPH3/ITGB4/ARPC5L/ITGB1/IQGAP2/HRAS/GNG12/RDX/ITGB5/SCIN/ARPC1A/SLC9A1/VAV3/EZR/BCAR1/VCL/PAK6/PTK2/WASF2/PDGFA/RAC3/ITGB8/ITGAV/ACTN4/RRAS2	1.7734632309921
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	12/826	82/9376	1.66113506171381	DUT/MGST3/GSTP1/RRM1/RRM2/TK1/GMPS/UMPS/NME4/IMPDH2/NME1/GSTA4	1.86890999284336
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	15/826	110/9376	1.5478758529606	CDK1/HSP90AA1/HSP90AB1/MAD2L1/ANAPC11/CCNA2/PKMYT1/KIF22/GNAI1/IGF1R/CDK2/CCNB2/CCNB1/MAPK14/MAPK13	1.79649064054512
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	11/826	75/9376	1.66482647296207	MGST3/GSTP1/TOP2A/BIRC5/BRCA1/MSH2/MSH6/PMAIP1/CDKN2A/BAD/GSTA4	1.79666339011834
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/826	41/9376	1.93799090533278	EGFR/CDH1/CCND1/HRAS/CDK4/CDKN2A/E2F1	1.87079413295376
Human Diseases	Cancer: specific types	hsa05214	Glioma	11/826	76/9376	1.64292086147572	EGFR/CCND1/HRAS/CALM2/CDK4/CDK6/CDKN2A/CAMK2G/IGF1R/E2F1/PDGFA	1.74910324023916
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	21/826	170/9376	1.40219341974078	EGFR/MGST3/GSTP1/MET/CCND1/HRAS/BRD7/LRP5/CDK4/SMARCA2/CDK6/CDKN2A/SMARCC1/BAD/IGF1R/ACTL6A/GAB1/E2F1/TCF7L2/SMARCA4/GSTA4	1.64481304139194
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	18/826	142/9376	1.43887051120281	MGST3/CTSL/GSTP1/HSP90B1/HSP90AA1/HSP90AB1/CALM2/ASS1/TXN/GPC1/PTK2/PDGFA/RAC3/ITGAV/TXN2/MAPK14/MAPK13/GSTA4	1.63786552660796
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/826	34/9376	2.00313345677254	POLR2L/POLR2H/POLR3K/POLR2F/POLR2I/POLR2K	1.82125537668822
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/826	19/9376	2.38970307123742	GCSH/GLDC/DHTKD1/PDHA1	1.88461701401454
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	37/826	333/9376	1.26123217648641	EGFR/ITGA6/GNAS/LAMB1/LAMA5/ITGB4/ITGB1/COL4A2/CCND1/LAMC1/CCNE1/ATP6V1C2/CCND3/HRAS/CCNA2/CCNE2/PARD3/RHEB/PSMC1/ITGB5/COL4A1/CDK4/HDAC2/CDK6/ATP6V1B1/PARD6B/RBL1/BAD/CDK2/DLG1/PTK2/E2F1/ITGB8/ITGAV/TCF7L2/TUBG1/DLG3	1.50863828481792
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	15/826	116/9376	1.46781330884195	GCSH/PGP/ACSS1/ECHS1/GLDC/ADH5/IDH2/FH/ACAT2/RPIA/PDHA1/MDH1/SUCLG1/IDH1/SHMT1	1.57575494495417
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	24/826	204/9376	1.33542230451503	EGFR/CTSL/MET/TIMP3/ITGB1/CCND1/HRAS/RPS6/RDX/ITGB5/ANK3/SLC9A1/VAV3/GPC1/EZR/CAMK2G/IGF1R/GAB1/PTK2/ITGAV/GPC3/RRAS2/MAPK14/MAPK13	1.50545439403914
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/826	20/9376	2.27021791767555	DHCR24/SQLE/FDFT1/EBP	1.76742392812336
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	17/826	138/9376	1.39832263045233	CDK1/SMC3/MAD2L1/ANAPC11/CCNE1/PKMYT1/CCNE2/FBXO5/CALM2/CAMK2G/IGF1R/CDK2/YWHAE/CCNB2/CCNB1/MAPK14/MAPK13	1.46513670996101
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	9/826	63/9376	1.6215842269111	ALDH7A1/ECHS1/EZH2/DHTKD1/HADH/ACAT2/SMYD2/KMT5A/PLOD2	1.53857284529413
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/826	37/9376	1.84071723054774	UXS1/UGP2/GFPT1/PGM1/PMM1/GALE	1.5925505530329
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/826	73/9376	1.55494377922983	EGFR/MET/CCND1/HRAS/CDK4/CDK6/EML4/CDKN2A/BAD/E2F1	1.47942008843694
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	11/826	83/9376	1.50436127074885	SLC27A2/SOD1/PRDX5/PXMP2/IDH2/PMVK/PRDX1/ECI2/IDH1/SLC25A17/ACSL3	1.43448302170546
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/826	38/9376	1.79227730342806	UXS1/UGP2/GFPT1/PGM1/PMM1/GALE	1.52101915282158
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	13/826	105/9376	1.40537299665629	UBB/HRAS/PHB2/RPS27A/TOMM40/BNIP3/SIAH1/FIS1/MTX2/MTX1/E2F1/VCP/RRAS2	1.29831112620204
NA	NA	hsa04981	Folate transport and metabolism	5/826	31/9376	1.83082090135125	TYMS/DHFR/FOLR1/SLC19A1/SHMT1	1.44009523139961
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/826	77/9376	1.47416747901009	EGFR/CCND1/RAD51/BRCA2/CDK4/CDK6/CDKN2A/BAD/E2F1/RAC3	1.29852886381061
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/826	50/9376	1.58915254237288	ALDH7A1/SMS/OAT/SRM/PYCR2/CKMT1B/GAMT	1.29824798510914
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	6/826	41/9376	1.66113506171381	GCSH/ALDH7A1/GLDC/GRHPR/SHMT1/GAMT	1.31861363208571
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	18/826	157/9376	1.30139880631082	CDH1/BMP7/CCND1/ID1/BIRC5/AMOT/CCND3/FRMD6/PARD3/DLG5/YAP1/RASSF6/TEAD1/PARD6B/DLG1/YWHAE/TCF7L2/DLG3	1.18370109993275
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	12/826	99/9376	1.37588964707609	EGFR/GNAS/CCND1/HRAS/CDK4/CDKN2A/BAD/IGF1R/PTK2/E2F1/MAPK14/MAPK13	1.16860243750178
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	9/826	71/9376	1.43887051120281	EGFR/LDHB/SLC2A1/MET/IDH2/HRAS/PDHA1/SLC1A5/IDH1	1.15371885592356
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	15/826	133/9376	1.28019807387719	EGFR/CCND1/HRAS/FOXO4/BNIP3/IGF1R/CDK2/SKP2/CCNB2/INSR/PLK2/HOMER1/CCNB1/MAPK14/MAPK13	1.0115261019571
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	10/826	83/9376	1.36760115522623	RBBP7/EZH2/SUZ12/RBBP4/CBX3/CBX4/HDAC2/AURKB/TFDP1/ASXL1	1.04551567797504
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	17/826	154/9376	1.25304235715858	GGH/QPRT/DHFR/UMPS/GCLM/NME4/UGP2/COQ4/NME1/MOCS2/MMAB/SHMT1/VKORC1/CTPS1/PMM1/PTS/ALAD	0.984087307599446
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	17/826	155/9376	1.24495821291885	EGFR/GNAS/CCND1/CCNE1/CCNE2/PBX1/FH/CDK4/CDK6/CDKN2A/GNA11/GNAI1/CAMK2G/CDK2/E2F1/LDLR/TCF7L2	0.955787722582477
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/826	18/9376	1.89184826472962	PRDX1/MMAB/CD320	1.17714051687458
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	12/826	105/9376	1.29726738152888	ITGA6/GNAS/DAG1/ITGB4/ITGB1/ADRB1/ITGB5/SGCE/LMNA/DMD/ITGB8/ITGAV	0.952075131001223
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	17/826	157/9376	1.22909887262689	SLC2A1/CD24/BSG/CALR/PBX1/ITGB5/TMEM30B/SLC16A1/DUSP5/CAMK2G/BCAR1/PTK2/ITGAV/PPARG/MAPK14/MAPK13/UQCRFS1	0.899753356163386
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/826	116/9376	1.27210486766302	CLDN4/CLDN7/ITGB1/JAM3/GNAI1/VAV3/EZR/BCAR1/VCL/PTK2/ACTN4/MAPK14/MAPK13	0.916542096306558
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/826	37/9376	1.53393102545645	ASS1/NIT2/GFPT1/PPAT/RIMKLB	1.01141277825138
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	15/826	137/9376	1.24282002792457	CTSL/TUBA1B/PARP1/CTSV/TUBA1C/BIRC5/HRAS/PMAIP1/LMNB1/PARP2/BAD/LMNA/CAPN1/DFFA/LMNB2	0.889866605836233
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/826	28/9376	1.6215842269111	HACD3/TECR/ECHS1/HADH	1.02379323085999
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	10/826	87/9376	1.30472294119284	EGFR/CCND1/BIRC5/MSH2/HRAS/MSH6/PMAIP1/BAD/RAC3/TCF7L2	0.887509275966214
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	36/826	362/9376	1.1288376386232	EGFR/ITGA6/HSP90B1/LAMB1/MET/LAMA5/HSP90AA1/ITGB4/HSP90AB1/ITGB1/COL4A2/CCND1/LAMC1/FLT1/CCNE1/BRCA1/CCND3/HRAS/GNG12/CCNE2/RPS6/RHEB/ITGB5/EFNA1/COL4A1/CDK4/CDK6/BAD/IGF1R/CDK2/YWHAE/INSR/PTK2/PDGFA/ITGB8/ITGAV	0.777017623686884
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/826	29/9376	1.56566752943141	FRMD6/YAP1/RASSF6/TEAD1	0.948236639090295
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	22/826	214/9376	1.166934443665	CDK1/PDIA3/CALR/WEE1/CHEK1/DDB1/HRAS/GNG12/CALM2/AP1S1/AP1S3/GNA11/GNAI1/BAD/PAK6/CCNB2/PTK2/RAC3/CCNB1/AP1M2/MAPK14/MAPK13	0.767803878458421
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	11/826	99/9376	1.26123217648641	EGFR/HRAS/CHPT1/RHEB/PLPP3/DGKD/SLC44A2/WASF2/SLC44A1/PDGFA/RAC3	0.812144097531164
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	19/826	184/9376	1.17212338140857	MET/BMP7/ITGB1/SEMA6A/RASA1/HRAS/NRP1/PARD3/EPHB4/EFNA1/SEMA6D/GNAI1/PARD6B/CAMK2G/PAK6/PTK2/RAC3/SEMA3F/PLXNB1	0.732885918741485
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	4/826	30/9376	1.5134786117837	PGAP2/GPAA1/DPM2/PIGX	0.875513207330036
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/826	70/9376	1.29726738152888	SLC2A1/MET/EPAS1/HRAS/FH/BAD/PAK6/GAB1	0.775902869627662
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/826	21/9376	1.6215842269111	CHPF/CHST14/B3GAT3	0.886299167522737
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/826	12/9376	1.89184826472962	COQ4/VKORC1	0.96082323467519
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/826	71/9376	1.27899600995805	EGFR/MET/ATP6V1C2/JAM3/TJP1/ATP6V1B1/MAPK14/MAPK13	0.733434918044188
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	11/826	103/9376	1.21225228613743	GNAS/LAMB1/LAMA5/COL4A2/LAMC1/COL4A1/PRDX1/GNA11/VCL/PTK2/ACTN4	0.673214503382738
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	18/826	178/9376	1.14786299208314	SERPINF1/NOTUM/CCND1/LGR5/RNF43/CCND3/LGR4/LRP5/CACYBP/CAMK2G/TLE1/SIAH1/ZNRF3/TBL1X/RAC3/DAAM1/TCF7L2/RUVBL1	0.61903526882076
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/826	52/9376	1.30974110635128	LRP2/LRPAP1/VDAC1/VDAC3/MYLIP/LDLR	0.696132626975197
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/826	42/9376	1.35132018909259	ALDH7A1/ECHS1/DHTKD1/HADH/ACAT2	0.709228957358034
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/826	42/9376	1.35132018909259	SLC40A1/GCLM/VDAC3/TFRC/ACSL3	0.709228957358034
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/826	32/9376	1.41888619854722	AKR1B1/UGP2/PGM1/GALE	0.737729636002614
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/826	32/9376	1.41888619854722	LDHB/ACSS1/ECHS1/SUCLG1	0.737729636002614
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	21/826	212/9376	1.1244003837544	EGFR/CDH1/GNAS/MET/ITGB1/FLT1/ID1/HRAS/PARD3/CALM2/EFNA1/GNAI1/PARD6B/VAV3/IGF1R/BCAR1/INSR/PDGFA/RAC3/MAPK14/MAPK13	0.569429175130811
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/826	33/9376	1.37588964707609	IDH2/DHTKD1/PDHA1/IDH1	0.672305655122288
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	13/826	128/9376	1.15284503631961	RRM1/PAICS/RRM2/PNP/GMPS/NUDT5/NME4/ADK/IMPDH2/NME1/PPAT/PGM1/ATIC	0.541159165315237
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/826	24/9376	1.41888619854722	EXTL2/HS6ST2/B3GAT3	0.638619282850444
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/826	77/9376	1.17933398320808	CCND1/HRAS/CDK4/HDAC2/CDK6/CDKN2A/BAD/E2F1	0.491114139552484
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	14/826	142/9376	1.1191215087133	ANAPC11/UBB/BRCA1/UBE2C/DDB1/RPS27A/UBE2S/SAE1/SIAH1/FANCL/SKP2/UBE2N/UBE4B/UBE2I	0.444561681905478
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/826	56/9376	1.21618817018333	RPN2/TUSC3/DDOST/FUT8/GANAB/DPM2	0.504325104861245
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	10/826	99/9376	1.14657470589674	ITGA6/DAG1/ITGB4/ITGB1/ITGB5/SGCE/LMNA/DMD/ITGB8/ITGAV	0.455685757560553
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	11/826	110/9376	1.13510895883777	EGFR/LDHB/SLC2A1/FLT1/EPAS1/RPS6/PDHA1/CAMK2G/IGF1R/INSR/TFRC	0.443023686286299
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/826	36/9376	1.26123217648641	GALNT11/C1GALT1/C1GALT1C1/GALNT18	0.488086825828771
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/826	112/9376	1.11483915600138	ITGA6/LAMB1/LAMA5/ITGB1/LAMC1/HSPA8/GNAI1/BAD/LDLR/MAPK14/MAPK13	0.380007645721528
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/826	26/9376	1.30974110635128	SLC19A1/SLC19A3/SLC5A6	0.491555226690405
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/826	80/9376	1.13510895883777	EGFR/MET/HRAS/RPS6/BAD/IGF1R/GAB1/PDGFA	0.377201740274512
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	5/826	48/9376	1.18240516545601	ALDH7A1/ECHS1/HADH/ACAT2/ACADM	0.393782205680104
NA	NA	hsa03272	Virion - Hepatitis viruses	5/826	48/9376	1.18240516545601	EGFR/CLDN4/DPP4/CLDN7/LDLR	0.393782205680104
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/826	59/9376	1.15434809373333	EGFR/CDH1/CCND1/HRAS/BAD/TCF7L2	0.369642443701046
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/826	70/9376	1.13510895883777	DAG1/CCND1/SGCE/DMD/RAC3/EIF4G1/CD55	0.352650291920601
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	10/826	103/9376	1.10204753285221	FUS/MSI2/UPF3A/NXT1/MAGOH/MAGOHB/PNN/WDR33/RNPS1/ALYREF	0.323670856039923
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/826	27/9376	1.26123217648641	ECHS1/HADH/ACAT2	0.422492083290246
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/826	49/9376	1.15827444779365	GALNT11/C1GALT1/GXYLT1/C1GALT1C1/GALNT18	0.345247436920643
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	8/826	82/9376	1.10742337447588	CTSL/HSP90AA1/PDIA3/HSP90AB1/CALR/HSPA5/HSPA8/NFYB	0.303666572307466
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/826	60/9376	1.13510895883777	HRAS/BAD/PTK2/RAC3/MAPK14/MAPK13	0.32631545022453
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	21/826	227/9376	1.05010079892481	EGFR/GNAS/PDIA3/CCND1/CALR/HRAS/GNG12/CALM2/RHEB/CDK4/CDK6/CDKN2A/GNA11/GNAI1/BCAR1/PTK2/E2F1/RAC3/ITGAV/MAPK14/MAPK13	0.237499866930527
Cellular Processes	Cell motility	hsa04814	Motor proteins	18/826	194/9376	1.05319387933402	TUBB/TUBA1B/MYH10/TUBB4B/TUBA1C/DYNLL2/KIF23/MYO1C/KIF21A/KIF22/KIF20B/DYNC1LI2/KIF4A/MYO7A/KIF11/KIFC1/TUBG1/KIF2C	0.232694698607443
NA	NA	hsa04382	Cornified envelope formation	20/826	217/9376	1.04618337220071	ITGA6/DSP/KRT7/KRT18/CLDN4/LAMA5/CLDN7/ITGB4/COL4A2/DSG2/KRT8/COL4A1/KRT23/TJP1/S100A13/CAPN1/KRT19/PRSS8/KRT10/PKP2	0.213936104109882
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	13/826	139/9376	1.0616126953159	EGFR/HSP90B1/GNAS/KRT18/HSP90AA1/HSP90AB1/HRAS/HSPA8/CALM2/KRT23/GNAI1/KRT19/KRT10	0.227459845969378
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/826	62/9376	1.09849254081075	SOD1/HRAS/HSPA8/HDAC2/IGF1R/INSR	0.241837516073016
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/826	51/9376	1.11285192042919	GNAS/PDIA4/ATP6V1C2/TJP1/ATP6V1B1	0.251166796414145
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/826	18/9376	1.26123217648641	FASN/ACSL3	0.34479741836658
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/826	52/9376	1.0914509219594	GNAS/HSD17B1/IGF1R/INSR/LDLR	0.205532844164054
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/826	75/9376	1.05943502824859	LRP2/HSP90B1/GNAS/GPX8/PDIA4/HSPA5/TTF2	0.160620468178889
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	18/826	200/9376	1.021598062954	TUBB/TUBA1B/MYH10/RPS3/CLDN4/TUBB4B/CLDN7/ARPC5L/ITGB1/TUBA1C/MYO1C/TJP1/ARPC1A/NCL/EZR/WASF2/MAPK14/MAPK13	0.0959612071580359
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	14/826	155/9376	1.0252597047567	CTSL/TUBB/TUBA1B/COLEC12/TUBB4B/ITGB1/CALR/TUBA1C/ATP6V1C2/ITGB5/ATP6V1B1/DYNC1LI2/TFRC/ITGAV	0.0985593232201941
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/826	53/9376	1.07085750833752	GNAS/ATP2B1/CLTA/AP2A2/AP2M1	0.160782424675191
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	10/826	110/9376	1.03191723530707	FBN1/BMP7/ID1/LTBP1/ID3/ID4/HDAC2/RBL1/TFRC/TFDP1	0.104656947721592
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/826	31/9376	1.09849254081075	HSPA5/SEC63/SPCS2	0.170721076130009
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/826	20/9376	1.13510895883777	UGP2/CYB5R1	0.187995149045527
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/826	67/9376	1.01651548552636	LDHB/ACSS1/ALDH7A1/ADH5/PDHA1/PGM1	0.0421667215835784
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/826	44/9376	1.03191723530707	RPN2/TUSC3/DDOST/FUT8	0.065956384802109
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	8/826	93/9376	0.976437814053998	EGFR/GNAS/HRAS/CALM2/GNA11/CAMK2G/MAPK14/MAPK13	-0.0709750132936038
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/826	59/9376	0.961956744777773	GNAS/ADRB1/GNAI1/INSR/MGLL	-0.0911083608909516
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/826	35/9376	0.972950536146662	AKR1B1/ENOSF1/PMM1	-0.0498297378075089
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/826	23/9376	0.987051268554585	MME/ENPEP	-0.0193245005895617
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/826	60/9376	0.94592413236481	GNAS/HRAS/GNA11/GNAI1/IGF1R	-0.1306041527183
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	12/826	144/9376	0.94592413236481	DUSP9/ID1/HRAS/ISL1/IL6ST/ID3/ID4/IGF1R/TBX3/RIF1/MAPK14/MAPK13	-0.203249482718126
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/826	36/9376	0.94592413236481	DCXR/AKR1B1/UGP2	-0.101035480938808
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/826	36/9376	0.94592413236481	AGL/UGP2/PGM1	-0.101035480938808
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/826	73/9376	0.932966267537895	RAN/PSIP1/PPIA/MLLT1/NELFCD/NELFE	-0.178704679859605
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/826	61/9376	0.930417179375223	SLC40A1/ATP2B1/MT2A/SLC34A2/TRPV6	-0.169460358879703
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	18/826	217/9376	0.941565034980641	EGFR/MGST3/HSP90B1/GNAS/HSP90AA1/HSP90AB1/CDC6/CCND1/BIRC5/CCND3/HRAS/ADRB1/KPNB1/KLF5/GNAI1/BAD/E2F1/GSTA4	-0.270689388070416
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	7/826	86/9376	0.92392589672842	EGFR/HRAS/BAD/CAMK2G/PAK6/GAB1/PTK2	-0.220277842881361
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/826	75/9376	0.908087167070218	IDH2/ASS1/RPIA/PYCR2/IDH1/SHMT1	-0.248390262305973
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/826	12/9376	0.94592413236481	CD46	-0.0582580603830205
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/826	76/9376	0.896138651714031	SLC27A2/DBI/ACSL3/PPARG/ACADM/CPT2	-0.282560781128823
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/826	76/9376	0.896138651714031	GNAS/CALM2/SLC9A1/GNAI1/EZR/CAMK2G	-0.282560781128823
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	12/826	150/9376	0.908087167070218	EGFR/CDH1/MET/CCND1/CCNE1/HRAS/CCNE2/LRP5/CDK2/GAB1/E2F1/TCF7L2	-0.352701787743648
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	13/826	163/9376	0.905301623612947	PCNA/CCNE1/BIRC5/DDB1/HRAS/CCNA2/CCNE2/BAD/CDK2/VDAC3/E2F1/MAPK14/MAPK13	-0.379077845960701
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/826	65/9376	0.873160737567517	ALDH7A1/AKR1B1/PLPP3/DGKD/MGLL	-0.318936943168409
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	20/826	248/9376	0.915410450675623	TUBB/TUBA1B/HSP90B1/RPS3/TUBB4B/HSP90AA1/ARPC5L/HSP90AB1/TUBA1C/HRAS/DYNLL2/CSE1L/TXN/ARPC1A/ANXA2/DYNC1LI2/TCF7L2/TXN2/MAPK14/MAPK13	-0.419611459659376
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/826	103/9376	0.881638026281765	COL14A1/MME/DPP4/COL4A2/COL4A1/KCNN4/SLC1A5/COL21A1	-0.375416438645707
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/826	27/9376	0.840821450990943	HACD3/TECR	-0.257440249859316
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/826	79/9376	0.862108070003372	ATP6V1C2/SLC6A4/CLTA/ATP6V1B1/AP2A2/AP2M1	-0.382537120881992
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/826	28/9376	0.810792113455552	ATP6V1C2/ATP6V1B1	-0.311638785353597
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/826	93/9376	0.854383087297248	GNAS/ATP2B1/ADRB1/CALM2/KCNN4/SLC9A1/TRPV6	-0.438633424697378
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/826	14/9376	0.810792113455552	FUT8	-0.220197071401578
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/826	68/9376	0.834638940321891	CCND1/HRAS/CCNA2/BAD/TCF7L2	-0.425355566095162
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	20/826	253/9376	0.897319335049622	EGFR/ARPC5L/ITGB1/UBB/RPS27A/CBX3/FOXO4/ARPC1A/FNBP1L/BNIP3/VDAC1/BCAR1/VCL/CAPN1/PTK2/WASF2/UBE2N/ACTN4/MAPK14/MAPK13	-0.514603457860194
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	13/826	168/9376	0.878358122910181	HMGB1/PARP1/HSP90AA1/PPIA/HSP90AB1/SLC25A5/SLC25A4/VDAC1/CAMK2G/CAPN1/VDAC3/CHMP4C/SLC25A6	-0.494478830344542
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	12/826	156/9376	0.873160737567517	EGFR/CLDN4/CLDN7/CCND1/HRAS/CDK4/CDK6/BAD/CDK2/YWHAE/E2F1/LDLR	-0.496527322048319
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/826	69/9376	0.822542723795487	HRAS/VAV3/RAC3/MAPK14/MAPK13	-0.459839319912471
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/826	56/9376	0.810792113455552	HSPD1/HSPA8/BNIP3/VCP	-0.441385331774562
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/826	120/9376	0.851331719128329	MAGED1/HRAS/CALM2/BAD/CAMK2G/YWHAE/GAB1/MAPK14/MAPK13	-0.509436284222837
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/826	15/9376	0.756739305891848	ACP1	-0.293054944294149
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/826	44/9376	0.773937926480299	GNAS/DYNLL2/DYNC1LI2	-0.467153153046661
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	12/826	160/9376	0.851331719128329	CDH1/ITGA6/CLDN4/CADM1/CLDN7/ITGB1/CNTNAP2/JAM3/PTPRF/ITGB8/ITGAV/CDH3	-0.589521545769995
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	11/826	148/9376	0.843662064001047	EGFR/CCND1/BRCA1/HRAS/LRP5/BRCA2/CDK4/CDK6/IGF1R/E2F1/TCF7L2	-0.595846020697885
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/826	136/9376	0.834638940321891	CD46/CCND1/CCNE1/CCND3/HSPA8/CCNE2/CDK4/CDK6/BAD/CDK2	-0.603753025073136
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/826	31/9376	0.732328360540498	RPIA/PGM1	-0.463966001504791
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/826	31/9376	0.732328360540498	ALDH7A1/ECHS1	-0.463966001504791
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	19/826	250/9376	0.862682808716707	EGFR/ARPC5L/HRAS/HSPA8/PARD3/FOLR1/EPN2/SH3GLB2/CLTA/ARPC1A/SNX4/PARD6B/IGF1R/VPS25/CHMP4C/TFRC/LDLR/AP2A2/AP2M1	-0.683986119286374
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	10/826	138/9376	0.822542723795487	ARPC5L/ITGB1/ARPC1A/VAV3/BCAR1/PTK2/WASF2/RAC3/MAPK14/MAPK13	-0.652735119572975
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/826	32/9376	0.709443099273608	BIRC5/PMAIP1	-0.511719978730137
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	15/826	201/9376	0.847096237938636	SPINT1/MET/FUS/FLT1/HPGD/CCNA2/PBX1/FUT8/MLLT1/HDAC2/ASPSCR1/IGF1R/PTK2/PDGFA/PPARG	-0.681091982059993
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/826	100/9376	0.794576271186441	ITGA6/CD24/MME/CD59/CSF2RA/TFRC/CD55	-0.641893300152735
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/826	17/9376	0.667711152257513	CDO1	-0.426204575062349
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/826	101/9376	0.786709179392516	COL4A2/CCND1/HRAS/COL4A1/CDK4/MAPK14/MAPK13	-0.669836019437818
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	10/826	140/9376	0.810792113455552	CDH1/TFAM/CCND1/HRAS/GNG12/RPS6/CALM2/SLC9A1/GNAI1/RRAS2	-0.70105791174616
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	16/826	216/9376	0.840821450990943	HSPD1/HSP90B1/HSP90AA1/HSP90AB1/HSPA5/HRAS/HSPA8/CALM2/VAV3/BAD/CAMK2G/PTK2/LDLR/PPARG/MAPK14/MAPK13	-0.735624669067499
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	12/826	166/9376	0.820560693135739	ATP2B1/SLC25A5/ADRB1/SLC25A4/CALM2/GNA11/GNAI1/VDAC1/BAD/VDAC3/INSR/SLC25A6	-0.724994006700758
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/826	115/9376	0.789641014843668	EGFR/GNAS/GATA3/LRP5/GNA11/GNAI1/MMP15/SLC34A2	-0.705462039413022
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/826	18/9376	0.630616088243207	FUCA1	-0.487545680141416
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	9/826	130/9376	0.785844663810766	EGFR/GNAS/COL4A2/HRAS/GNG12/COL4A1/GNAI1/MAPK14/MAPK13	-0.764216194260465
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/826	104/9376	0.764015645371578	CHPT1/PLPP3/DGKD/CDS1/PISD/CDIPT/PCYT2	-0.752152275266336
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	10/826	144/9376	0.788270110304009	ALDH7A1/CCND1/ACADVL/ADH5/TRA2B/FASN/TCF7L2/MAPK14/MAPK13/ACADM	-0.795807676115251
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/826	19/9376	0.597425767809354	NAGLU	-0.545942700345889
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/826	78/9376	0.727633947972931	ITGB1/CALM2/GNAI1/MAPK14/MAPK13	-0.750754788019605
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	13/826	183/9376	0.806361555458527	RAN/POP7/NOP56/NHP2/NOP58/SNU13/TCOF1/NXT1/GNL3/FBL/IMP3/SBDS/REXO2	-0.822206876535551
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	11/826	158/9376	0.790265730836424	ATP6V1C2/HRAS/CLIP1/RPS6/RHEB/LRP5/ATP6V1B1/IGF1R/SKP2/INSR/SLC38A9	-0.826365529747585
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/826	65/9376	0.698528590054014	GNAS/PBX1/GNA11/LDLR	-0.758048951853725
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/826	79/9376	0.718423391669476	MGST3/GSTP1/AKR7A2/ADH5/GSTA4	-0.781144371981077
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/826	51/9376	0.667711152257513	CHPT1/PLPP3/PAFAH1B3	-0.739552548633826
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/826	107/9376	0.742594645968636	LDHB/SLC2A1/GNAS/CALM2/PDHA1/CAMK2G/PHKB	-0.832310988208436
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/826	94/9376	0.724537633300706	HSP90B1/HSP90AA1/HSP90AB1/TRAF4/MAPK14/MAPK13	-0.834253473888576
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/826	37/9376	0.61357241018258	COMT/ADH5	-0.732000546093195
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	17/826	238/9376	0.810792113455552	EGFR/MET/FLT1/RASA1/HRAS/GNG12/CALM2/EFNA1/FOXO4/BAD/IGF1R/PAK6/INSR/GAB1/PDGFA/RAC3/RRAS2	-0.918956048975945
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	8/826	122/9376	0.744333743500179	CCND1/CCNA2/RHEB/IGF1R/INSR/FASN/PPARG/HMGCR	-0.883448392281106
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	8/826	122/9376	0.744333743500179	SLC2A1/CCND1/HRAS/RHEB/HDAC2/SLC9A1/BAD/ITGAV	-0.883448392281106
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/826	122/9376	0.744333743500179	GNAS/HRAS/GNA11/GNAI1/BCAR1/PTK2/MAPK14/MAPK13	-0.883448392281106
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	10/826	149/9376	0.761818093179713	EGFR/GNAS/HRAS/RHEB/PLPP3/DGKD/INSR/GAB1/PDGFA/RRAS2	-0.910886459344441
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/826	38/9376	0.597425767809354	QPRT/PNP	-0.772864645932664
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	18/826	254/9376	0.804407923585823	EGFR/GNAS/MET/ATP2B1/FLT1/SLC25A5/ASPH/ADRB1/SLC25A4/CALM2/MCOLN3/GNA11/VDAC1/CAMK2G/VDAC3/PDGFA/PHKB/SLC25A6	-0.98223563499297
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/826	83/9376	0.683800577613116	POLR2L/POLR2H/POLR3K/POLR2F/POLR2K	-0.899321040677047
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/826	69/9376	0.65803417903639	GNAS/ADRB1/CALM2/GNAI1	-0.886125009402221
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/826	69/9376	0.65803417903639	GNAS/CALM2/HDAC2/CAMK2G	-0.886125009402221
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	9/826	138/9376	0.740288451415939	HRAS/RPS6/CALM2/RHEB/PTPRF/BAD/INSR/PHKB/FASN	-0.955288238077831
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/826	22/9376	0.515958617653533	ALDH7A1	-0.706460289036185
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	6/826	98/9376	0.694964668676187	ARPC5L/SCIN/PLPP3/ARPC1A/VAV3/WASF2	-0.943471104235581
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/826	98/9376	0.694964668676187	GNAS/ATP2B1/CALM2/GNA11/CAMK2G/LDLR	-0.943471104235581
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/826	23/9376	0.493525634277292	ASS1	-0.755855059645378
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/826	23/9376	0.493525634277292	B4GAT1	-0.755855059645378
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/826	23/9376	0.493525634277292	MDH1	-0.755855059645378
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/826	56/9376	0.608094085091664	LRP2/CCND1/GLI3	-0.914240550092465
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/826	71/9376	0.639498004979027	CCND1/HRAS/MAPK14/MAPK13	-0.947700833473305
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	23/826	323/9376	0.808281921153832	EGFR/STMN1/MET/DNMT1/TIMP3/CCND1/CCNE1/BRCA1/EZH2/HRAS/CDCA5/KIF23/CCNE2/RDX/EFNA1/SOX4/HDAC2/CDK6/CDKN2A/EZR/E2F1/PDGFA/UBE2I	-1.08983480610573
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/826	86/9376	0.659947069091728	SLC2A1/GNAS/KCNN4/GNA11/CAMK2G	-0.984646849119568
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	11/826	169/9376	0.738828316403284	HMGB1/CTSL/UBB/HRAS/RPS27A/RHEB/EIF2AK4/BNIP3/BAD/IGF1R/RRAS2	-1.06488564805777
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/826	101/9376	0.674322153765013	GNAS/HRAS/CALM2/GNAI1/CAMK2G/TCF7L2	-1.02278546971594
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	13/826	196/9376	0.75287839106587	CCND1/UBB/HRAS/RPS27A/GNG12/CALM2/IL6ST/CDK4/CDK6/E2F1/TCF7L2/MAPK14/MAPK13	-1.08670088922845
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/826	73/9376	0.62197751169193	MGST3/GSTP1/ADH5/GSTA4	-1.00776706400788
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/826	103/9376	0.661228519711324	GNAS/CALR/GNA11/GNAI1/MAPK14/MAPK13	-1.07450373333134
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/826	43/9376	0.527957655273382	ACAT2/PLPP3	-0.964266676033506
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/826	90/9376	0.630616088243207	HRAS/RHEB/IGF1R/INSR/PPARG	-1.09440355644918
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/826	90/9376	0.630616088243207	SLC2A1/GNAS/SLC9A1/LDLR/HMGCR	-1.09440355644918
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	5/826	90/9376	0.630616088243207	EGFR/HRAS/EML4/MAPK14/MAPK13	-1.09440355644918
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	8/826	133/9376	0.682772306067833	GNAS/COMT/GNG12/CALM2/GNAI1/CAMK2G/MAPK14/MAPK13	-1.14520449136525
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/826	122/9376	0.651292025562656	HRAS/CDK4/VAV3/DLG1/PAK6/MAPK14/MAPK13	-1.20495173516372
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/826	46/9376	0.493525634277292	MMAB/ALAD	-1.07025722346762
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/826	28/9376	0.405396056727776	GCNT2	-0.97935479346039
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/826	109/9376	0.624830619543728	HSP90AA1/HSP90AB1/GATA3/IL6ST/MAPK14/MAPK13	-1.22451372715453
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/826	29/9376	0.391416882357853	CALM2	-1.02017665864637
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/826	125/9376	0.635661016949153	ORMDL1/HRAS/DEGS1/GNAI1/RAC3/MAPK14/MAPK13	-1.27455597223899
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	9/826	154/9376	0.663375365554542	GNAS/ATP2B1/ADRB1/CALM2/SLC9A1/GNAI1/CAMK2G/MAPK14/MAPK13	-1.30914062729614
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/826	65/9376	0.52389644254051	HRAS/KCNN4/GNA11	-1.19716096053904
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	16/826	250/9376	0.726469733656174	CTSL/CTSV/SLC29A1/ATP6V1C2/FUCA1/MCOLN3/CLTA/AP1S1/AP1S3/ATP6V1B1/NAGLU/AP2A2/SLC38A9/AP1M2/AP2M1/CLN6	-1.36247256177781
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/826	97/9376	0.58510771074112	GNAS/GNG12/CALM2/GNAI1/CAMK2G	-1.27662471464889
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/826	49/9376	0.463309779117458	GNAS/GNAI1	-1.17069385338592
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/826	66/9376	0.515958617653533	HSD17B1/COMT/STS	-1.22651319374119
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/826	98/9376	0.579137223896823	CALM2/IMPA2/DGKD/CDS1/CDIPT	-1.30172418512465
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/826	67/9376	0.508257742763182	HRAS/CALM2/CAMK2G	-1.25549798815701
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/826	31/9376	0.366164180270249	ALDH7A1	-1.09865307913959
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/826	99/9376	0.57328735294837	GNAS/CALM2/CAMK2G/MAPK14/MAPK13	-1.3266059422925
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/826	115/9376	0.592230761132751	APP/GNAS/HRAS/SLC6A4/GNG12/GNAI1	-1.36749908090401
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	11/826	187/9376	0.667711152257513	HSP90AA1/HSP90AB1/TXN/VDAC1/YWHAE/VDAC3/BRCC3/TRIP6/TXN2/MAPK14/MAPK13	-1.42657644137009
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/826	70/9376	0.486475268073331	MGST3/GSTP1/GSTA4	-1.34036001890764
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/826	88/9376	0.515958617653533	F5/CD46/CD59/CD55	-1.41793175819431
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/826	89/9376	0.510161329814729	SLC38A1/GNG12/GNAI1/GABRE	-1.4431216843601
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/826	105/9376	0.540528075637034	HRAS/CALM2/RRAS2/MAPK14/MAPK13	-1.4715768354045
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/826	55/9376	0.412766894122826	DEGS1/PLPP3	-1.35754184954868
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/826	91/9376	0.498948992895724	GNAS/GNG12/GNAI1/GABRE	-1.49280914189971
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	5/826	109/9376	0.520692182953107	SLC2A1/SLC27A2/PTPRF/GFPT1/INSR	-1.56441072241183
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/826	38/9376	0.298712883904677	INSR	-1.34633559562122
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/826	38/9376	0.298712883904677	UNG	-1.34633559562122
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/826	95/9376	0.477940614247483	CTSL/FLT1/ATP6V1C2/ATP6V1B1	-1.58956001204942
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/826	78/9376	0.436580368783759	ISYNA1/IMPA2/CDIPT	-1.55302021911965
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/826	78/9376	0.436580368783759	ITGB1/MAPK14/MAPK13	-1.55302021911965
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	18/826	300/9376	0.681065375302663	EGFR/STMN1/DUSP9/MET/FLT1/RASA1/HRAS/HSPA8/GNG12/EFNA1/DUSP5/IGF1R/INSR/PDGFA/RAC3/RRAS2/MAPK14/MAPK13	-1.74504913026858
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	9/826	173/9376	0.590519111534101	FDPS/SLC25A5/CCND3/SLC25A4/NXT1/CDK4/CDK6/VDAC1/SLC25A6	-1.6896026498406
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/826	62/9376	0.366164180270249	HDAC2/TLE1	-1.55631359471255
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/826	41/9376	0.276855843618969	GABRE	-1.44228887225454
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/826	115/9376	0.493525634277292	HRAS/GNG12/GNA11/GNAI1/CAMK2G	-1.69851760164951
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/826	63/9376	0.36035205042469	HPGD/PTGES	-1.58328497274656
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/826	63/9376	0.36035205042469	GLI3/TCF7L2	-1.58328497274656
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/826	99/9376	0.458629882358696	KRT18/KRT23/KRT19/KRT10	-1.68306428226311
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/826	116/9376	0.489271102947316	GNAS/SLC38A1/GNG12/GNAI1/HOMER1	-1.7203092982839
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/826	195/9376	0.582107158378345	HMGB1/SLC25A5/HAT1/SLC25A4/HDAC2/VDAC1/VDAC3/SLC25A6/MAPK14/MAPK13	-1.83286234226274
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	12/826	226/9376	0.602712721506782	GNAS/ATP2B1/ADRB1/CALM2/SLC9A1/GNAI1/VAV3/BAD/CAMK2G/GLI3/RAC3/RRAS2	-1.87906124645618
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/826	44/9376	0.257979308826766	HSPD1	-1.5333722287442
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/826	154/9376	0.515958617653533	EGFR/GNAS/CCND1/HRAS/CALM2/GNAI1/CAMK2G	-1.88244761102004
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/826	47/9376	0.241512544433569	INSR	-1.62021403321083
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/826	70/9376	0.324316845382221	SLC2A1/ACSL3	-1.7636125966147
Organismal Systems	Immune system	hsa04611	Platelet activation	5/826	126/9376	0.450440063030862	GNAS/ITGB1/GNAI1/MAPK14/MAPK13	-1.93028784410043
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/826	91/9376	0.374211744671793	HRAS/VAV3/RAC3	-1.86444576540488
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/826	72/9376	0.315308044121603	MAPK14/MAPK13	-1.81267200455799
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/826	50/9376	0.227021791767554	MET	-1.70332355238469
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	9/826	193/9376	0.529325421219687	HRAS/GNG12/PARD3/GNAI1/VAV3/BAD/BCAR1/PTK2/RAC3	-2.05352365265109
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/826	93/9376	0.366164180270249	GATA3/MAPK14/MAPK13	-1.90926707031248
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	8/826	180/9376	0.504492870594565	SRSF2/PDIA3/CALR/RHEB/SRPK1/BAD/SRSF7/ALYREF	-2.08631213093987
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/826	181/9376	0.501705617165866	HSPD1/CALM2/NFYB/BAD/CAMK2G/MAPK14/HSPA9/MAPK13	-2.10398198359992
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/826	134/9376	0.423548118969318	MYH10/GNAS/CALD1/CALM2/GNA11	-2.08893574903177
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/826	168/9376	0.472962066182405	EGFR/CCND1/CCND3/HRAS/IL6ST/CSF2RA/PDGFA	-2.14242913128427
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/826	102/9376	0.333855576128757	GNAS/ATP2B1/SLC9A1	-2.1024590294537
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/826	191/9376	0.475438307366606	GNAS/SLC29A1/HRAS/HAT1/GNG12/CALM2/HDAC2/GNAI1	-2.27649279342366
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/826	66/9376	0.171986205884511	GATA3	-2.09810541024244
NA	NA	hsa04081	Hormone signaling	9/826	219/9376	0.466483133768948	GNAS/SLC40A1/ADRB1/GNG12/GNA11/GNAI1/IGF1R/INSR/ITGAV	-2.48305425068246
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/826	68/9376	0.166927788064378	ADH5	-2.14289811032782
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	4/826	142/9376	0.319749002489513	FHL2/PPARG/MAPK14/MAPK13	-2.53869792985072
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/826	143/9376	0.317512995479097	SNRPD1/SNRPB/SNRPD3/ACTN4	-2.55613385060036
NA	NA	hsa04082	Neuroactive ligand signaling	7/826	199/9376	0.399284558385146	GNAS/ADRB1/SLC6A4/GNG12/GNA11/GNAI1/GABRE	-2.66218095765584
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/826	105/9376	0.216211230254814	PARP1/UBE2I	-2.51028482100695
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/826	109/9376	0.208276873181243	MAPK14/MAPK13	-2.58410170818371
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/826	133/9376	0.256039614775437	HRAS/VAV3/RAC3	-2.68572634373835
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/826	119/9376	0.190774614930718	MAPK14/MAPK13	-2.7612164451591
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/826	100/9376	0.113510895883777	IL6ST	-2.77003742399717
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	4/826	298/9376	0.152363618635943	BMP7/TNFRSF12A/IL6ST/CSF2RA	-4.62184350356028
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/826	370/9376	0.184071723054774	TMEM97/ADRB1/GABRE/PGRMC2/CHRNB1/CHRNA5	-4.97713567459446
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/826	449/9376	0.0505616462733974	CALM2/CAMK2G	-6.40810735993616