category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	122/1784	250/9376	2.56473542600897	CTSL/GAA/PSAP/CTSC/CTSD/HEXA/CTSV/NAGLU/VPS13C/ATP6AP1/CTSA/MANBA/LGMN/FUCA1/SLC38A9/GNS/GLB1/VPS13A/GUSB/SUMF1/LAMP2/HGSNAT/GNPTAB/CLTC/HEXB/MCOLN3/SLC29A3/LAMP1/ATP6V1B1/NEU1/ASAH1/ABCA5/TPP1/TLR3/CLN5/CTSF/CLN3/CTSO/SMPD1/IGF2R/NPC1/PLA2G15/SCARB2/ATP6V0A1/PPT1/NAGA/DNASE2/CTBS/SLC17A5/AP2A2/GGA1/SGSH/SORT1/ACP2/GM2A/SLC29A1/TMEM175/SLC11A2/GLA/AP3D1/SLC15A4/HYAL2/LIPA/CLCN7/TCIRG1/FUCA2/NAGPA/ATP6V0B/ARSA/ENTPD4/AP2A1/PIKFYVE/CTSH/OSTM1/CLN8/SLC29A2/GALC/AP2B1/SPG11/MFSD8/PPT2/MTOR/GNPTG/TPCN1/CTSB/TELO2/AP4E1/AGA/BORCS6/ROGDI/AP3S2/MCOLN1/CTSZ/M6PR/AP1M1/AP1B1/LAPTM4A/DMXL1/CLN6/ATP6V1C2/VPS39/ARSG/ACP5/AP1S3/TFE3/ATP6V1A/IDS/OSBP/VPS11/ATP6V0A2/VPS35/ATP6V1E2/TFEB/ATP6V1H/MLST8/NCOA7/BLOC1S6/GGA3/AP1S1/AP1G1/CD164/GALNS	12.1555790184419
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	87/1784	174/9376	2.62780269058296	RRBP1/HSP90B1/HSPA5/GANAB/LMAN1/RPN2/P4HB/PDIA3/SEC62/CKAP4/PDIA4/SIL1/OS9/PPP1R15A/CANX/ERP29/DDOST/CALR/MOGS/SEL1L/SEC61A1/ATF6/MAN1A2/LMAN2/MBTPS1/SEC63/EDEM3/UBXN4/PRKCSH/ATF6B/STT3B/DDIT3/RPN1/XBP1/MAN1B1/WFS1/TUSC3/DNAJC3/UGGT1/EDEM2/HSPA1B/UGGT2/DNAJC1/ERO1B/HYOU1/SAR1B/PDIA6/DNAJB1/HSPA1A/STT3A/SYVN1/MAGT1/MAN1C1/DNAJB11/SSR1/DNAJC10/ERLEC1/BCAP31/AMFR/UBE2G2/HSPA8/TRAM1/UBE4B/SEC31A/SEC24D/UBXN8/DERL2/MBTPS2/STUB1/UBXN2A/NPLOC4/SVIP/DERL1/HSPA4L/DNAJB12/ERN1/BCAP29/MAP2K7/BCL2/SSR2/CAPN1/SEC24B/CUL1/PLAA/SEC23A/NFE2L2/MAN1A1	10.5060686712953
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	31/1784	56/9376	2.90935297885971	GANAB/RPN2/MAN2A1/DDOST/MOGS/MAN1A2/STT3B/FUT8/RPN1/MAN1B1/TUSC3/ALG5/ALG8/MGAT1/B4GALT1/STT3A/MAGT1/MAN1C1/DPM3/MAN2A2/DOLK/ALG10B/ALG1/ALG2/DPAGT1/MGAT3/ALG14/ALG6/ALG11/MGAT2/MAN1A1	6.94667920749289
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	46/1784	108/9376	2.23849858827437	TPR/RANBP2/PNN/UPF2/THOC2/KPNB1/DDX39B/POM121C/TNPO1/RANBP17/POM121/UPF3A/AHCTF1/TMEM33/NXF1/IPO9/UPF3B/UPF1/NUP210/KPNA6/IPO7/TNPO2/XPO6/XPO1/NUP153/SUMO4/NUP214/PHAX/AAAS/NUP107/SRRM1/NUP133/NUP188/DDX19A/NUP205/NUP155/NDC1/XPO7/ACIN1/NUP160/IPO8/XPO4/TNPO3/NUP98/NUP58/RNPS1	6.27508112179089
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	29/1784	55/9376	2.77113738279658	PSAP/HEXA/PLPP3/GLB1/DEGS1/B4GALT5/HEXB/NEU1/ASAH1/SMPD1/SGPP1/GM2A/GLA/KDSR/ARSA/CERS5/SPTLC3/SPTLC2/CERS6/GALC/SGPL1/SMPD4/UGCG/CERS2/SGMS1/SAMD8/ACER3/GBA2/SPTLC1	6.38568224375031
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	31/1784	62/9376	2.62780269058296	TLE4/NCSTN/JAG1/NOTCH3/MAML2/ADAM17/MAML3/HES1/EP300/DVL3/APH1A/SPEN/TLE1/CREBBP/RBPJ/DTX4/PSEN2/RFNG/NUMB/PSEN1/NOTCH2/ATXN1/JAG2/CTBP1/MAML1/DVL1/DTX2/ATXN1L/HDAC2/TLE3/ITCH	6.23353573424972
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	23/1784	44/9376	2.74724826742764	RPN2/HEXA/MAN2A1/DDOST/MAN1A2/HEXB/STT3B/FUT8/RPN1/MAN1B1/TUSC3/MGAT1/B4GALT1/STT3A/MAGT1/MAN1C1/MAN2A2/ALG1/ALG2/ALG14/ALG11/MGAT2/MAN1A1	5.63116891978176
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	79/1784	250/9376	1.66077130044843	EGFR/TFRC/IGF1R/EEA1/FOLR1/KIF5B/CLTC/ZFYVE16/LDLR/FGFR2/IGF2R/HSPA1B/WWP1/AP2A2/HSPA1A/PARD3/EPN3/HGS/WIPF2/IST1/TGFBR1/ARFGEF1/PRKCI/GIT2/VPS36/HSPA8/CYTH3/HLA-E/EPN2/ARFGEF2/MVB12B/TGFBR2/ARFGAP2/AGAP1/EHD3/AP2A1/VPS37C/PSD4/USP8/RABEP1/PIP5K1A/RAB11FIP4/PSD3/GBF1/SH3KBP1/ACAP2/AP2B1/RAB5B/ZFYVE27/SH3GLB2/CBL/RAB11FIP2/SMAD2/DNAJC6/ACTR2/PIP5K1C/CHMP6/WASL/RAB11FIP1/LDLRAP1/EHD1/MDM2/NEDD4/HRAS/ARFGAP1/CBLB/ARPC1B/VPS25/IQSEC1/VPS35/SMURF2/PIP5K1B/AGAP3/PARD6B/ITCH/ZFYVE9/EPS15L1/CHMP1A/HLA-C	5.13317307335858
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	14/1784	21/9376	3.50373692077728	CHPF/B3GAT3/CHST14/XYLT1/CHST12/DSE/CHSY1/CHST11/CHPF2/B4GALT7/B3GALT6/XYLT2/DSEL/CHST3	5.5677715632924
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	45/1784	122/9376	1.93854296846284	ITGAV/SLC2A1/SLC9A1/ATP1A1/NCOA3/ATP2A2/NOTCH3/NCOR1/SLC16A2/MED13/EP300/KRAS/BMP4/SIN3A/PDPK1/NCOA2/MED16/PIK3R1/MED12/CREBBP/RXRA/PIK3CA/PIK3R3/AKT2/GSK3B/NCOA1/WNT4/NOTCH2/PLCB1/MTOR/MED13L/PIK3CB/MED1/MED24/MED14/ATP1B3/MDM2/PRKACB/MED12L/HRAS/RXRB/THRB/HDAC2/TSC2/RCAN1	5.05794720192126
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	55/1784	169/9376	1.71040411813092	CTSL/CTSD/IGF1R/LAMP2/RB1CC1/LAMP1/ATG9A/BIRC6/WDFY3/IRS2/EIF2AK4/VMP1/KRAS/PDPK1/SUPT20H/MTMR3/CFLAR/PIK3R1/C9orf72/PIK3CA/PIK3R3/UVRAG/EPG5/NBR1/AKT2/ATG2B/ATG2A/ATG9B/MTOR/ATG14/CTSB/WIPI2/PIK3CB/ATG4D/ERN1/MTMR4/DAPK1/BCL2/VPS39/GORASP1/PRKACB/HRAS/WDR45B/WIPI1/ATG10/PRKAA1/VPS11/MLST8/ATG12/PIK3C3/PTEN/TSC1/TSC2/BCL2L1/NRBF2	4.51746414824725
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	35/1784	93/9376	1.97791600366459	LAMA5/LAMB1/ITGAV/ITGA6/ITGB1/LAMC1/COL4A2/GADD45B/CDK6/FN1/COL4A1/LAMB2/NFKBIA/XIAP/GADD45G/ITGA3/TRAF4/PIK3R1/RXRA/PIK3CA/PIK3R3/AKT2/BIRC2/PIK3CB/IKBKB/BCL2/RXRB/NFKB1/POLK/LAMB4/CDKN1A/PTK2/FHIT/PTEN/BCL2L1	4.59413566739382
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	94/1784	333/9376	1.48356428177056	EGFR/ITGB4/LAMA5/LAMB1/ITGAV/ITGA6/ITGB1/LAMC1/COL4A2/ATP6AP1/CDK6/ITGB5/FN1/COL4A1/CREB3L2/DLG1/ITGB8/JAG1/NOTCH3/UBR4/MAML2/TCF7L2/ATP6V1B1/LAMB2/TLR3/MAML3/FZD6/FZD5/HES1/ATM/ATP6V0A1/CHD4/EP300/DVL3/KRAS/PARD3/PRKCI/BCAP31/ITGA3/TCIRG1/FZD3/PIK3R1/UBE3A/HLA-E/FZD10/CREBBP/ATP6V0B/RBPJ/PIK3CA/PIK3R3/AKT2/APC/RFNG/GSK3B/SCRIB/ATR/PSEN1/WNT4/NOTCH2/MTOR/DLG2/PIK3CB/IKBKB/MAML1/PXN/TNFRSF1A/CREB1/MAGI1/PPP2R2D/ATP6V1C2/MDM2/PRKACB/HRAS/ATP6V1A/NFKB1/DVL1/LAMB4/ATP6V0A2/CDKN1A/ATP6V1E2/HDAC2/ATP6V1H/PTK2/IRF3/RBL2/EIF2AK2/PTEN/TSC1/TSC2/PARD6B/PPP2R3B/SOS2/IRF1/HLA-C	4.35536973845153
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	32/1784	83/9376	2.02625749635313	JARID2/PHC3/EP300/OGT/MGA/MTF2/DCAF7/KDM2A/FOXK1/BAP1/CREBBP/HCFC1/CBX4/SUZ12/ASXL2/FBRS/AEBP2/YY1/BCORL1/YAF2/USP7/PCGF3/SFMBT2/TEX10/ASXL1/SFMBT1/BMI1/AUTS2/HDAC2/RYBP/LCOR/FOXK2	4.55221099694078
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	38/1784	106/9376	1.88408494796514	EGFR/HSP90B1/SPINT1/SLC19A1/IGF1R/FOLR1/CREB3L2/TCF7L2/FGFR2/EP300/NFKBIA/KRAS/SLC46A1/PDPK1/PIK3R1/ERBB2/CREBBP/PIK3CA/PIK3R3/AKT2/PLAU/GSK3B/MTOR/PIK3CB/IKBKB/CREB1/PDGFA/BCL2/MDM2/HRAS/NFKB1/PDGFD/PDGFC/CDKN1A/PTEN/PDGFB/SOS2/ETV5	4.43723086864279
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	36/1784	99/9376	1.91112922951488	EGFR/JUN/FOS/PLPP3/SLC44A2/WASF2/SLC44A1/KRAS/PDPK1/PIK3R1/SLC44A5/GPCPD1/PIK3CA/DGKD/PIK3R3/CHPT1/AKT2/PIP5K1A/SP1/RAC3/MTOR/SLC22A5/PIK3CB/DGKH/PIP5K1C/PDGFA/HRAS/PDGFD/PDGFC/PIP5K1B/DGKA/PDGFB/TSC1/TSC2/SLC44A3/SOS2	4.41772585338761
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	47/1784	142/9376	1.73953135855492	HERC2/DDB1/UBE4A/BIRC6/UBR5/HUWE1/WWP1/CUL5/SIAH1/SYVN1/XIAP/MAP3K1/FBXW11/SOCS1/UBE2G2/PPIL2/TRIP12/PIAS1/UBE3A/UBE4B/UBE3C/HERC4/UBE2H/UBE3B/STUB1/BIRC2/RHOBTB1/CBL/UBA6/HERC1/ANAPC1/KLHL9/UBE2R2/MDM2/NEDD4/UBA1/ANAPC4/CBLB/SMURF2/MGRN1/CUL1/FBXW7/CDC23/UBOX5/UBE2Q1/ITCH/UBE2E2	4.30438188331248
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	62/1784	203/9376	1.60516026419846	EGFR/JUN/ITGB4/LAMA5/LAMB1/ITGAV/ITGA6/ITGB1/LAMC1/MET/COL4A2/FLT1/IGF1R/ITGB5/FN1/DIAPH1/COL4A1/ITGB8/ROCK1/ACTN4/FLNB/LAMB2/ARHGAP5/VCL/PPP1R12A/RAPGEF1/XIAP/PDPK1/ITGA3/ROCK2/PIK3R1/ERBB2/PPP1R12B/PIK3CA/PIK3R3/AKT2/PIP5K1A/GSK3B/RAC3/EMP2/BIRC2/SHC1/PIK3CB/TLN1/PIP5K1C/PXN/DOCK1/ACTN1/PDGFA/BCL2/PAK6/HRAS/PDGFD/PDGFC/LAMB4/VAV3/PIP5K1B/PTK2/ARHGAP35/PTEN/PDGFB/SOS2	4.22539865293036
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	34/1784	93/9376	1.9214041178456	EGFR/CDH1/MET/IQGAP1/PTPRF/IGF1R/LMO7/CTNND1/PTPRM/INSR/ROCK1/ACTN4/TCF7L2/WASF2/VCL/TJP1/EP300/SORBS1/PARD3/TGFBR1/KRIT1/ROCK2/ERBB2/CREBBP/TGFBR2/BAIAP2/PTPRJ/RAC3/YES1/ARHGAP29/ACTN1/WASL/SMAD4/SMURF2	4.32864939935055
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	57/1784	184/9376	1.62809514525249	SEMA6A/ITGB1/MET/SEMA6D/NRP1/EPHB4/PLXNB1/RASA1/PLXNA1/BMP7/ROCK1/SEMA4B/SEMA3F/BMPR2/NFATC3/PLXNB2/SEMA7A/KRAS/RYK/PLXNA2/ARHGEF12/PARD3/EPHA2/CAMK2G/EFNA5/SRGAP1/LIMK2/SEMA4C/PDPK1/EFNA1/FZD3/GNAI2/ROCK2/PIK3R1/EPHB3/SEMA3E/PIK3CA/LRIG2/PIK3R3/NFATC2/GSK3B/RAC3/NTN4/ROBO1/WNT4/SEMA4G/PIK3CB/UNC5B/DPYSL2/PAK6/PTPN11/HRAS/ABL1/PTK2/PARD6B/PPP3CA/SEMA3B	4.17094347023288
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	53/1784	170/9376	1.6385122658929	EGFR/MET/GADD45B/LRP5/IGF1R/CDK6/MGST3/ARID1A/TCF7L2/GAB1/FZD6/FZD5/SMARCA2/DVL3/KRAS/SMARCC1/PBRM1/SMARCA4/GADD45G/TGFBR1/MGST2/FZD3/PIK3R1/BRD7/SMARCD2/FZD10/TGFBR2/PIK3CA/PIK3R3/ARID2/AKT2/LRP6/IGF2/APC/GSK3B/ARID1B/WNT4/MTOR/SHC1/SMAD2/PIK3CB/TXNRD2/FRAT2/SMAD4/HRAS/POLK/DVL1/CDKN1A/SMARCD1/PTEN/NFE2L2/BCL2L1/SOS2	4.0725196029243
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	11/1784	18/9376	3.21175884404584	HEXA/MANBA/FUCA1/GLB1/HEXB/NEU1/MAN2B2/FUCA2/MAN2C1/AGA/GBA2	4.5528932550939
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	13/1784	24/9376	2.84678624813154	EXTL2/B3GAT3/HS6ST2/XYLT1/EXT2/EXT1/B4GALT7/B3GALT6/NDST1/XYLT2/EXTL3/GLCE/HS2ST1	4.39111657892348
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	15/1784	30/9376	2.62780269058296	PGAP1/GPAA1/PIGT/PIGO/PIGS/PIGG/PIGM/PIGQ/PIGV/PIGK/PIGU/PGAP2/PIGX/B3GALT4/MPPE1	4.32866986309314
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	46/1784	144/9376	1.67887394120578	IL6ST/ZFHX3/IGF1R/RIF1/JARID2/ISL1/BMPR2/TBX3/FGFR2/FZD6/FZD5/DUSP9/REST/ID1/SMAD5/DVL3/ID4/KRAS/LIFR/BMP4/ACVR2B/ID2/KAT6A/FZD3/PIK3R1/FZD10/MAPK14/PIK3CA/ACVR2A/ID3/PIK3R3/BMPR1A/AKT2/APC/GSK3B/WNT4/SMAD2/PIK3CB/PCGF3/SMAD4/HRAS/BMI1/DVL1/SMARCAD1/STAT3/ACVR1	3.97949029693927
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	32/1784	90/9376	1.86865969108122	IGF1R/CREB3L2/INSR/RB1CC1/ATF6B/IRS2/KRAS/PIK3R1/ADCY6/PRKAB2/PIK3CA/PIK3R3/AKT2/ADCY7/CAT/MTOR/SESN2/PIK3CB/APPL1/FOXO3/CREB1/PRKACB/HRAS/NFKB1/EHMT2/PRKAA1/ADIPOR2/SESN1/ADCY2/TSC1/TSC2/EHMT1	4.01385378117937
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	43/1784	133/9376	1.69918068714387	EGFR/GADD45B/IGF1R/INSR/ATM/IRS2/EP300/HOMER1/KRAS/GADD45G/TGFBR1/PDPK1/PIK3R1/CREBBP/MAPK14/PRKAB2/TGFBR2/G6PC3/PIK3CA/PIK3R3/AKT2/FOXO4/CAT/PLK2/PIK3CB/STK4/IKBKB/USP7/FOXO3/SETD7/MDM2/SMAD4/HRAS/PRKAA1/CDKN1A/FOXO6/SGK3/ATG12/RBL2/PTEN/STAT3/FBXO25/SOS2	3.9365315011661
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	34/1784	98/9376	1.82337329550654	CDS1/ITPR2/SACM1L/INPPL1/CDIPT/MTMR3/IP6K2/PIK3R1/PI4KA/SYNJ1/PIK3CA/DGKD/PIK3R3/PIP5K1A/PIKFYVE/PIP4K2B/IP6K1/PLCB1/PIK3C2A/PIK3CB/DGKH/PIP5K1C/PI4KB/INPP4A/MTMR4/PPIP5K2/CDS2/PIP5K1B/INPP5F/PIK3C3/PTEN/DGKA/SYNJ2/PI4K2A	3.97180204119707
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	11/1784	19/9376	3.04271890488553	HEXA/NAGLU/GNS/GLB1/GUSB/HGSNAT/HEXB/SGSH/HYAL2/IDS/GALNS	4.32038109920396
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	60/1784	204/9376	1.54576628857821	EGFR/ITGAV/CTSL/ITGB1/MET/IQGAP1/ANK3/IGF1R/SLC9A1/GPC1/ITGB5/FN1/TIMP3/ERBB3/ROCK1/GPC3/ITPR2/GAB1/FZD6/FZD5/PPP1R12A/KRAS/RDX/ARHGEF12/CAMK2G/PDPK1/FZD3/ROCK2/PIK3R1/ERBB2/PPP1R12B/FZD10/MAPK14/PIK3CA/PIK3R3/AKT2/PLAU/IGF2/WNT4/MTOR/CBL/SMAD2/PIK3CB/DDX5/TWIST1/PXN/HCLS1/NUDT16L1/FRS2/MDM2/PRKACB/HSPG2/PTPN11/HRAS/TIAM1/CDKN1A/VAV3/PTK2/STAT3/SOS2	3.82027591476749
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	28/1784	77/9376	1.91112922951488	GADD45B/CDK6/NFKBIA/KRAS/GADD45G/TGFBR1/PIK3R1/TGFBR2/PIK3CA/PIK3R3/AKT2/CBL/SHC1/PIK3CB/BCR/IKBKB/CTBP1/MDM2/SMAD4/PTPN11/HRAS/ABL1/NFKB1/POLK/CDKN1A/HDAC2/BCL2L1/SOS2	3.89145651235698
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	28/1784	78/9376	1.88662757272623	ISYNA1/SACM1L/INPPL1/CDIPT/MTMR3/IP6K2/PI4KA/SYNJ1/MINPP1/PIK3CA/PIP5K1A/PIKFYVE/PIP4K2B/IP6K1/PLCB1/PIK3C2A/PIK3CB/PIP5K1C/PI4KB/INPP4A/MTMR4/PPIP5K2/PIP5K1B/INPP5F/PIK3C3/PTEN/SYNJ2/PI4K2A	3.81152459897034
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	36/1784	109/9376	1.73579627267865	SLC2A1/SLC27A2/PTPRF/CREB3L2/INSR/IRS2/SLC27A3/OGT/NFKBIA/CPT1A/PDPK1/PIK3R1/PRKAB2/G6PC3/PIK3CA/PIK3R3/SLC27A6/AKT2/GSK3B/MTOR/PIK3CB/IKBKB/PPARGC1B/TNFRSF1A/CREB1/SLC27A4/PTPN11/NFKB1/PPARA/PRKAA1/PTEN/STAT3/RPS6KA3/SREBF1/PYGB/GFPT1	3.74546906515812
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	40/1784	125/9376	1.68179372197309	CTSD/ORMDL1/DEGS1/ROCK1/GNAQ/GNA12/ASAH1/SMPD1/KRAS/SGPP1/PDPK1/GNAI2/ROCK2/PIK3R1/MAPK14/CERS5/SPTLC3/PIK3CA/PIK3R3/SPTLC2/AKT2/RAC3/CERS6/SGPL1/S1PR2/PLCB1/S1PR3/ABCC1/CERS2/PIK3CB/SGMS1/NSMAF/TNFRSF1A/BCL2/PPP2R2D/HRAS/SPTLC1/NFKB1/PTEN/PPP2R3B	3.71979175459605
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	48/1784	158/9376	1.59663960946813	CLIP1/SLC3A2/LRP5/IGF1R/SLC38A9/RICTOR/INSR/ATP6V1B1/FZD6/FZD5/DVL3/KRAS/PDPK1/FZD3/PIK3R1/FZD10/FNIP1/PIK3CA/PIK3R3/AKT2/LRP6/GSK3B/LPIN1/PRR5/WNT4/MTOR/SESN2/TELO2/LPIN2/PIK3CB/IKBKB/FNIP2/NPRL3/TNFRSF1A/ATP6V1C2/HRAS/ATP6V1A/PRKAA1/DVL1/ATP6V1E2/CAB39/ATP6V1H/MLST8/PTEN/TSC1/TSC2/RPS6KA3/SOS2	3.66629356742343
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	65/1784	232/9376	1.47247564558528	EGFR/ITGB4/ITGAV/ITGA6/ITGB1/IQGAP2/IQGAP1/MYH10/SLC9A1/ITGB5/FN1/DIAPH1/ITGB8/ROCK1/ACTN4/GNA12/DIAPH2/SCIN/WASF2/FGFR2/VCL/PPP1R12A/KRAS/NCKAP1/RDX/ARHGEF12/LIMK2/ITGA3/ROCK2/PIK3R1/PPP1R12B/PIK3CA/BAIAP2/PIK3R3/AKT2/PIP5K1A/PIKFYVE/APC/RAC3/PIP4K2B/CYFIP2/PFN2/PIK3CB/GNG12/ACTR2/PIP5K1C/ABI2/PXN/DOCK1/ACTN1/WASL/PDGFA/PAK6/HRAS/PDGFD/PDGFC/ARPC1B/TIAM1/VAV3/PIP5K1B/PTK2/ARHGAP35/PDGFB/SOS2/MYH9	3.53232190379506
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	28/1784	80/9376	1.83946188340807	EGFR/MET/IGF1R/NF1/ERBB3/GAB1/FGFR2/KRAS/PIK3R1/ERBB2/PIK3CA/PIK3R3/AKT2/GSK3B/MTOR/SHC1/PIK3CB/FOXO3/PDGFA/BCL2/HRAS/PDGFD/PDGFC/PTEN/STAT3/PDGFB/BCL2L1/SOS2	3.65513044568532
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	34/1784	104/9376	1.71817868230424	PLPP3/PISD/PLD3/CDS1/PLA2G15/LPCAT3/ETNK1/CDIPT/PTDSS2/PNPLA6/GPCPD1/GPD1L/DGKD/CEPT1/PCYT2/PTDSS1/CHPT1/MBOAT7/PLPP5/AGPAT1/GPAM/AGPAT4/LPIN1/LPIN2/SGMS1/AGPAT3/DGKH/GPAT4/SAMD8/LCAT/PGS1/CDS2/AGPAT5/DGKA	3.56999355032603
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	23/1784	62/9376	1.9496600607551	IGF1R/INSR/HSPA1B/IRS2/HSPA1A/KRAS/HSPA8/PIK3R1/ADCY6/PRKAB2/PIK3CA/PIK3R3/AKT2/ADCY7/CAT/MTOR/PIK3CB/FOXO3/PRKACB/HRAS/PRKAA1/HDAC2/ADCY2	3.63664463657242
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	14/1784	31/9376	2.37349920439751	HSPA5/SEC62/SEC61A1/SEC63/SRPRA/SPCS2/TMEM208/SRPRB/SPCS3/IMMP2L/BAG6/SGTA/OXA1L/IMMP1L	3.71299675576143
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	42/1784	138/9376	1.59953207252876	JUN/FOS/ITGB1/PKN2/FN1/ROCK1/GNAQ/WASF2/NFATC3/NFKBIA/ARHGEF12/WIPF2/GIT2/ROCK2/PIK3R1/MAPK14/PIK3CA/BAIAP2/PIK3R3/NFATC2/AKT2/PIP5K1A/GSK3B/RAC3/TAB2/PIK3CB/ACTR2/PIP5K1C/IKBKB/PXN/DOCK1/MAP2K7/WASL/PYCARD/NFKB1/ARPC1B/VAV3/MAP2K3/PIP5K1B/PTK2/IRF3/RPS6KA3	3.43928328322816
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	23/1784	63/9376	1.91871307566375	KMT2C/ASH1L/KMT2A/NSD1/SETD2/PLOD1/HADHA/PRDM2/KMT2B/PLOD3/KMT2E/DHTKD1/AASS/SETD7/KMT2D/SETD1B/PLOD2/DOT1L/EHMT2/KMT5C/PHYKPL/EHMT1/TMLHE	3.54658468470288
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	32/1784	99/9376	1.69878153734656	EGFR/JUN/FOS/IGF1R/JAG1/NCOA3/NOTCH3/NCOR1/KRAS/PIK3R1/ERBB2/ADCY6/MAPK14/PIK3CA/PIK3R3/AKT2/SP1/ADCY7/NOTCH2/MTOR/SHC1/PIK3CB/MED1/JAG2/BCL2/MDM2/PRKACB/HRAS/CDKN1A/PTK2/ADCY2/SOS2	3.38813108328166
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	49/1784	170/9376	1.51485096280665	JUN/ITGB1/CLDN4/MYH10/JAM3/DLG1/ROCK1/ACTN4/MARVELD3/AMOT/TJP1/F11R/AMOTL1/OCLN/RDX/PARD3/MAP3K1/RAPGEF2/MARVELD2/PRKCI/ROCK2/ERBB2/MPDZ/AMOTL2/CLDN19/PRKAB2/CLDN23/TJP2/ARHGAP17/SCRIB/DLG2/CLDN3/ACTR2/ACTN1/HCLS1/MAP2K7/MAGI1/PPP2R2D/PRKACB/NEDD4/TJAP1/PRKAA1/ARPC1B/CLDN7/TIAM1/RAPGEF6/SYMPK/PARD6B/MYH9	3.28379069692954
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	37/1784	120/9376	1.62047832585949	JUN/KIDINS220/MAGED1/RPS6KA5/GAB1/NFKBIA/KRAS/SORT1/RAPGEF1/CAMK2G/MAP3K1/PDPK1/PIK3R1/MAPK14/PIK3CA/PIK3R3/AKT2/PSEN2/GSK3B/PSEN1/SHC1/PIK3CB/IKBKB/SH2B1/FOXO3/MAP2K7/BCL2/FRS2/PTPN11/HRAS/ABL1/NFKB1/BDNF/RPS6KA3/SOS2/PRDM4/NTF4	3.31596951434951
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	41/1784	137/9376	1.57284540604236	JUN/FOS/CTSL/CTSC/CTSD/GADD45B/CTSV/SPTAN1/ITPR2/PMAIP1/DDIT3/CTSF/CTSO/ATM/NFKBIA/KRAS/XIAP/MCL1/GADD45G/PDPK1/CFLAR/PIK3R1/PIK3CA/PIK3R3/AKT2/CTSH/PARP1/BIRC2/CTSB/PIK3CB/IKBKB/ERN1/CTSZ/TNFRSF1A/BCL2/PIDD1/HRAS/NFKB1/CAPN1/AIFM1/BCL2L1	3.27408686961187
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	25/1784	73/9376	1.79986485656367	EGFR/MET/GADD45B/CDK6/KIF5B/KRAS/GADD45G/PDPK1/PIK3R1/ERBB2/EML4/RXRA/PIK3CA/PIK3R3/AKT2/PIK3CB/STK4/FOXO3/HRAS/RXRB/POLK/CDKN1A/FHIT/STAT3/SOS2	3.32561138919599
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	9/1784	17/9376	2.78237931944078	NRP2/DAG1/TFRC/MYH10/PCDH11X/LAMP2/LAMP1/PCDH11Y/MYH9	3.56545397804777
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	34/1784	110/9376	1.62445984508765	FBN1/TFRC/LTBP1/BMP7/ROCK1/NCOR1/ZFYVE16/BMPR2/ID1/SMAD5/EP300/ID4/BMP4/SIN3A/ACVR2B/TGFBR1/ID2/CREBBP/E2F4/TGFBR2/LEMD3/ACVR2A/ID3/BMPR1A/SP1/BAMBI/SMAD2/THSD4/SMAD4/SMURF2/HDAC2/CUL1/ACVR1/ZFYVE9	3.19344672312363
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	43/1784	148/9376	1.52696642831172	EGFR/JUN/FOS/GADD45B/LRP5/IGF1R/CDK6/JAG1/NCOA3/NOTCH3/TCF7L2/FZD6/FZD5/HES1/DVL3/KRAS/GADD45G/FZD3/PIK3R1/ERBB2/FZD10/PIK3CA/PIK3R3/AKT2/LRP6/SP1/APC/GSK3B/NCOA1/WNT4/NOTCH2/MTOR/SHC1/PIK3CB/BRCA2/JAG2/FRAT2/HRAS/POLK/DVL1/CDKN1A/PTEN/SOS2	3.13231172808723
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	21/1784	59/9376	1.87063920346584	EGFR/CDH1/GADD45B/TCF7L2/KRAS/GADD45G/PDPK1/PIK3R1/ERBB2/PIK3CA/PIK3R3/AKT2/APC/GSK3B/PIK3CB/FOXO3/HRAS/POLK/CDKN1A/PTEN/SOS2	3.25185476212094
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	45/1784	157/9376	1.50638370797749	GADD45B/CDK6/ZFP36L1/ITPR2/RAD50/NFATC3/ATM/KRAS/TRPM7/GADD45G/TGFBR1/FBXW11/RAD9A/PIK3R1/HIPK2/HLA-E/E2F4/MAPK14/TGFBR2/PIK3CA/PIK3R3/NFATC2/AKT2/ATR/MTOR/SMAD2/PIK3CB/TRPV4/HIPK1/FOXO3/SERPINE1/MDM2/HIPK3/HRAS/NFKB1/CAPN1/CDKN1A/MAP2K3/RBL2/PTEN/TSC1/TSC2/LIN52/PPP3CA/HLA-C	3.10164869809099
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	45/1784	157/9376	1.50638370797749	CDH1/DLG5/DLG1/BMP7/FRMD6/TCF7L2/TEAD1/LATS2/BMPR2/FZD6/FZD5/RASSF6/AMOT/ID1/DVL3/PARD3/BMP4/TGFBR1/FBXW11/ID2/PRKCI/FZD3/FZD10/TGFBR2/BMPR1A/TEAD3/APC/GSK3B/SCRIB/BIRC2/WNT4/DLG2/SMAD2/LATS1/YAP1/SAV1/SERPINE1/PPP2R2D/WWC1/SMAD4/WWTR1/LIMD1/DVL1/MOB1B/PARD6B	3.10164869809099
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	25/1784	75/9376	1.75186846038864	GADD45B/CDK6/PMAIP1/MDM4/STEAP3/ATM/PPP1R13L/SIAH1/ZMAT3/GADD45G/SHISA5/EI24/ATR/PERP/SESN2/SERPINE1/BCL2/MDM2/PIDD1/CDKN1A/SESN1/PTEN/TSC2/ZNF385A/BCL2L1	3.16892995875662
NA	NA	hsa04518	Integrin signaling	44/1784	154/9376	1.50160153747598	EGFR/FBN1/ITGB4/CDH1/LAMA5/LAMB1/ITGAV/ITGA6/ITGB1/LAMC1/MET/COL4A2/FLT1/FRAS1/IGF1R/ITGB5/FN1/FERMT1/COL4A1/ITGB8/ACTN4/FLNB/LAMB2/VCL/FREM2/ITGA3/PIK3R1/ERBB2/PIK3CA/PIK3R3/AKT2/GSK3B/RAC3/MTOR/PIK3CB/TLN1/PXN/ACTN1/PDGFA/PDGFD/PDGFC/LAMB4/PTK2/PDGFB	3.04236715598261
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	18/1784	49/9376	1.9306305481834	GALNT11/GXYLT1/C1GALT1C1/C1GALT1/OGT/GALNT1/B4GALT1/GALNT6/PLOD3/GALNT7/GALNT18/XXYLT1/POFUT1/POGLUT1/RFNG/FUT10/POMT1/POFUT2	3.16598840074026
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	40/1784	138/9376	1.52336387859882	PTPRF/INSR/FASN/IRS2/FLOT2/PHKB/SORBS1/KRAS/RAPGEF1/INPPL1/SOCS1/PDPK1/PRKCI/PIK3R1/PRKAR2A/PDE3B/PRKAB2/G6PC3/PIK3CA/PIK3R3/AKT2/GSK3B/MTOR/CBL/SHC1/PIK3CB/IKBKB/ACACA/PHKA2/PRKACB/EXOC7/HRAS/CBLB/PRKAA1/MKNK1/TSC1/TSC2/SREBF1/PYGB/SOS2	3.00233585689283
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	35/1784	117/9376	1.57218964393852	BPTF/ARID1A/RSF1/BAZ1B/BAZ2A/BAZ2B/SMARCA2/CHD4/EPC1/SMARCC1/BRD9/PBRM1/SMARCA4/BRD8/EP400/BRD7/SMARCD2/ARID2/INO80/INO80D/ARID1B/BAZ1A/DMAP1/DPF2/YY1/ING3/NFRKB/CECR2/TRRAP/EPC2/INO80E/HDAC2/SS18L1/GATAD2B/SMARCD1	3.01894948074922
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	25/1784	77/9376	1.70636538349543	EGFR/GADD45B/CDK6/KRAS/GADD45G/TGFBR1/PIK3R1/ERBB2/TGFBR2/PIK3CA/PIK3R3/AKT2/RAC3/MTOR/SMAD2/PIK3CB/BRCA2/IKBKB/SMAD4/NFKB1/POLK/CDKN1A/STAT3/RALBP1/BCL2L1	3.01690482827599
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	60/1784	227/9376	1.38914679678394	EGFR/ITGAV/PDIA3/CDK6/IL10RB/CALR/CREB3L2/AKAP13/ROCK1/GNAQ/ITPR2/ATF6B/GNA12/TAPBP/NFATC3/NFKBIA/KRAS/TAPBPL/ARHGEF12/GNA11/GNAI2/ROCK2/PIK3R1/ADCY6/HLA-E/MAPK14/PIK3CA/PIK3R3/NFATC2/AKT2/SP1/ADCY7/GSK3B/B2M/RAC3/PLCB1/MTOR/PIK3CB/GNG12/GNG11/IKBKB/PXN/TNFRSF1A/CREB1/MDM2/PRKACB/HRAS/NFKB1/CDKN1A/PTK2/IRF3/ADCY2/STAT3/GNB4/TSC1/TSC2/SOS2/PPP3CA/GNG5/HLA-C	2.87703097898572
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	25/1784	78/9376	1.68448890421985	DHX36/BTG1/CNOT6L/DCP1A/CNOT1/XRN1/DDX6/DIS3L/PAN3/BTG2/PABPC4/TOB1/DCP2/TOB2/XRN2/LSM8/PNPT1/PARN/CNOT2/BTG3/CNOT6/PABPC1L/PABPC1/PAN2/EXOSC10	2.94255037448715
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	31/1784	103/9376	1.58178414384605	FUS/PNN/UPF2/SMG1/PABPN1/PCF11/DDX39B/UPF3A/NXF1/UPF3B/UPF1/RNMT/MSI2/CPSF7/GSPT2/WDR82/CPSF2/SMG6/SMG5/PABPC4/WDR33/SRRM1/PPP2R2D/DDX19A/ACIN1/PABPC1L/PABPC1/SYMPK/SMG7/RNPS1/PPP2R3B	2.87789753116731
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	12/1784	29/9376	2.1747332611721	FRMD6/TEAD1/LATS2/RASSF6/TEAD3/LATS1/YAP1/SAV1/WWC1/WWTR1/LIMD1/MOB1B	3.07119298108301
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	42/1784	150/9376	1.47156950672646	EGFR/CDH1/MET/GADD45B/LRP5/TCF7L2/GAB1/FGFR2/ABCB1/FZD6/FZD5/DVL3/KRAS/GADD45G/TGFBR1/FZD3/PIK3R1/ERBB2/FZD10/TGFBR2/RXRA/PIK3CA/PIK3R3/AKT2/JUP/LRP6/APC/GSK3B/WNT4/MTOR/SHC1/SMAD2/PIK3CB/FRAT2/BCL2/SMAD4/HRAS/RXRB/POLK/DVL1/CDKN1A/SOS2	2.82221166303
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	27/1784	87/9376	1.63104994587908	EGFR/JUN/FOS/GADD45B/TCF7L2/PMAIP1/KRAS/GADD45G/TGFBR1/PIK3R1/TGFBR2/PIK3CA/PIK3R3/AKT2/APC/GSK3B/RAC3/MTOR/SMAD2/PIK3CB/APPL1/BCL2/SMAD4/HRAS/POLK/CDKN1A/SOS2	2.86644651181212
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	23/1784	71/9376	1.70252005305375	EGFR/JUN/MET/JAM3/ATP6AP1/ADAM10/ATP6V1B1/ADAM17/ATP6V0A1/TJP1/F11R/NFKBIA/TCIRG1/ATP6V0B/MAPK14/IKBKB/ATP6V1C2/PTPN11/ATP6V1A/NFKB1/ATP6V0A2/ATP6V1E2/ATP6V1H	2.88027977324471
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	11/1784	26/9376	2.2235253535702	SLC19A1/SLC19A3/SLC52A3/LMBRD1/SLC5A6/ABCD4/SLC46A1/SLC19A2/BTD/SCARB1/ABCC1	3.02829936284861
NA	NA	hsa03272	Virion - Hepatitis viruses	17/1784	48/9376	1.86136023916293	EGFR/CLDN4/DPP4/TGOLN2/LAMP2/LAMP1/CD81/LDLR/OCLN/IST1/CLDN19/CLDN23/SCARB1/CLDN3/HSPG2/CLDN7/CHMP1A	2.9001211070896
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	48/1784	178/9376	1.41724190053912	JUN/LGR5/LGR4/SERPINF1/RNF43/LRP5/ZNRF3/TLE4/TCF7L2/TBL1X/CHD8/DAAM1/FZD6/FZD5/NFATC3/EP300/DVL3/NOTUM/SIAH1/RYK/CAMK2G/FBXW11/FZD3/ROCK2/FZD10/TLE1/CREBBP/NFATC2/LRP6/APC/GSK3B/BAMBI/RAC3/PSEN1/WNT4/PLCB1/CELSR2/TBL1XR1/FRAT2/CTBP1/PRKACB/SMAD4/DVL1/CUL1/VANGL1/PRICKLE1/TLE3/PPP3CA	2.72430781984248
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	18/1784	52/9376	1.81924801655743	LRP2/LRP1/LRPAP1/ABCA1/LDLR/NPC1/SORT1/LIPA/NCEH1/LIPG/APOE/MYLIP/SOAT1/SCARB1/LCAT/ANGPTL4/LDLRAP1/STARD3	2.87157987843673
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	35/1784	122/9376	1.50775564213776	FOS/CREB3L2/JUNB/GNAQ/ITPR2/ATF6B/IRS2/EP300/KRAS/MAP3K1/GHR/SOCS1/GNA11/GNAI2/PIK3R1/ADCY6/CREBBP/MAPK14/PIK3CA/PIK3R3/AKT2/ADCY7/GSK3B/PLCB1/MTOR/SHC1/PIK3CB/CREB1/PRKACB/HRAS/MAP2K3/PTK2/ADCY2/STAT3/SOS2	2.73637043343543
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	43/1784	158/9376	1.43032298348186	GADD45B/ATRX/CDK6/PRKDC/NIPBL/ATM/EP300/PDS5A/SMC1A/PDS5B/GADD45G/STAG2/STAG1/SMC3/CREBBP/E2F4/MAU2/GSK3B/CDKN1C/ATR/SMAD2/ESCO1/MCM6/WAPL/CDC14B/ORC5/ANAPC1/MDM2/MCM2/SMAD4/ABL1/MCM5/ANAPC4/RAD21/CDKN1A/DBF4B/HDAC2/CUL1/RBL2/CDC23/TFDP2/MCM3/MCM7	2.64429374318685
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	33/1784	115/9376	1.50813023981283	EGFR/FOS/JUND/MMP15/LRP5/EGR1/CREB3L2/AKAP13/GNAQ/ITPR2/ATF6B/GNA12/MMP14/PDE4B/GATA3/WNK1/GNA11/GNAI2/ADCY6/RXRA/LRP6/SP1/ADCY7/PLCB1/WNK2/SLC34A2/CREB1/BCL2/MAFB/PRKACB/RXRB/CDKN1A/ADCY2	2.65766344533791
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	55/1784	214/9376	1.35073970076694	JUN/FOS/PDIA3/CALR/DDB1/GNAQ/ITPR2/TAPBP/NFATC3/ATM/CUL5/NFKBIA/KRAS/TAPBPL/LIMK2/FBXW11/GNA11/GNAI2/PIK3R1/HLA-E/MAPK14/PIK3CA/PIK3R3/NFATC2/AKT2/B2M/RAC3/ATR/MTOR/TAB2/PIK3CB/GNG12/GNG11/IKBKB/PXN/TNFRSF1A/AP1M1/AP1B1/MAP2K7/BCL2/PAK6/AP1S3/HRAS/NFKB1/MAP2K3/CUL1/PTK2/IRF3/GNB4/AP1S1/AP1G1/BCL2L1/PPP3CA/GNG5/HLA-C	2.5159478423627
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	57/1784	224/9376	1.33736386931454	JUN/FOS/SLC2A1/NRP1/EGR1/CANX/CALR/CREB3L2/DLG1/ATF6B/NFATC3/ATM/EP300/NFKBIA/KRAS/LTBR/XIAP/MAP3K1/TGFBR1/PIK3R1/ADCY6/HLA-E/CREBBP/TGFBR2/PIK3CA/PIK3R3/NFATC2/AKT2/ADCY7/B2M/ATR/XPO1/ZFP36/SMAD2/PIK3CB/TLN1/IKBKB/ANAPC1/TNFRSF1A/CREB1/TRRAP/PRKACB/SMAD4/HRAS/ELK4/NFKB1/ANAPC4/CDKN1A/HLA-DRA/CDC23/PTEN/ADCY2/IL15RA/BCL2L1/ETS2/PPP3CA/HLA-C	2.47724828274367
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	11/1784	28/9376	2.06470211402947	GCNT2/B3GNT2/B3GNT3/B4GALT1/ST3GAL6/B4GALT4/ST3GAL4/A4GALT/B3GNT5/B3GALNT1/FUT4	2.73497111343439
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	42/1784	157/9376	1.40595812744566	LRP1/ITGAV/SLC2A1/PBX1/BSG/ITGB5/CALR/ABCA1/ATP2A2/SLC16A1/ADAM10/ANO6/ADAM17/DNMT3A/XKR8/NFATC3/PLA2G15/TMEM30A/CD47/CPT1A/CAMK2G/LIPA/MAPK14/ATP11B/RXRA/NFATC2/SIRPA/P2RY6/TMEM30B/ADAM9/RAB5B/ATP11C/TGFBRAP1/DUSP5/CREB1/DOCK1/VPS8/VPS39/PTPN11/VPS11/PTK2/RAB14	2.48653240148723
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	17/1784	51/9376	1.75186846038864	PDIA4/ATP6AP1/SEC61A1/ATP6V1B1/ATP6V0A1/TJP1/TCIRG1/ATP6V0B/TJP2/SLC12A2/KDELR1/ATP6V1C2/PRKACB/ATP6V1A/ATP6V0A2/ATP6V1E2/ATP6V1H	2.60980163341185
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	12/1784	32/9376	1.97085201793722	ATG9A/ATG2B/ATG2A/ATG9B/MTOR/WIPI2/ATG4D/WIPI1/ATG10/MLST8/ATG12/PIK3C3	2.66665342318211
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	33/1784	119/9376	1.45743678637374	JUN/FOS/CREB3L2/JUNB/JAG1/RPS6KA5/ATF6B/MMP14/ADAM17/NFKBIA/XIAP/RHBDF1/CFLAR/PIK3R1/MAPK14/PIK3CA/PIK3R3/AKT2/TAB3/BIRC2/TAB2/PIK3CB/IKBKB/TNFRSF1A/BAG4/CREB1/MAP2K7/NFKB1/RPS6KA4/MAP2K3/ITCH/CYLD/IRF1	2.43430168287959
Human Diseases	Cancer: specific types	hsa05218	Melanoma	22/1784	73/9376	1.58388107377603	EGFR/CDH1/MET/GADD45B/IGF1R/CDK6/KRAS/GADD45G/PIK3R1/PIK3CA/PIK3R3/AKT2/PIK3CB/PDGFA/MDM2/HRAS/POLK/PDGFD/PDGFC/CDKN1A/PTEN/PDGFB	2.42761203089685
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	51/1784	201/9376	1.33351181313165	SPINT1/MET/GADD45B/FLT1/PBX1/IGF1R/FUS/DUSP6/KMT2A/JMJD1C/FUT8/NCOR1/DDIT3/ATM/NFKBIZ/CCNT1/GADD45G/SIN3A/ID2/ASPSCR1/CEBPA/TGFBR2/RXRA/JUP/PLAU/SP1/ETV6/REL/BIRC2/DDX5/PDGFA/MDM2/RXRB/ELK4/TFE3/DOT1L/NFKB1/POLK/SIX4/BMI1/KLF3/EWSR1/CDKN1A/CCNT2/HDAC2/MEN1/SS18L1/PTK2/KDM6A/BCL2L1/ETV5	2.31692074001243
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	18/1784	57/9376	1.65966485721029	HACD3/CPT2/FASN/HADHA/PPT1/ELOVL1/ACSL3/CPT1A/HSD17B12/ACADVL/TECR/ACADS/ELOVL4/PPT2/HACD2/ACACA/ACADL/ACADSB	2.42148110019444
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	23/1784	78/9376	1.54972979188226	CDH1/ITGB1/MET/FN1/CLTC/GAB1/WASF2/VCL/ELMO3/PIK3R1/PIK3CA/PIK3R3/ARHGAP10/CBL/SHC1/PIK3CB/ACTR2/PXN/DOCK1/HCLS1/WASL/ARPC1B/PTK2	2.36323422483169
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	72/1784	300/9376	1.26134529147982	EGFR/JUN/FOS/MET/GADD45B/FLT1/JUND/DUSP1/IGF1R/DUSP6/NF1/RASA1/ERBB3/INSR/RPS6KA5/GNA12/DDIT3/FGFR2/NFATC3/DUSP9/HSPA1B/TAOK1/MAP3K2/HSPA1A/KRAS/MAP3K4/TAOK3/EPHA2/MAP3K1/EFNA5/RAPGEF2/GADD45G/TGFBR1/EFNA1/HSPA8/ERBB2/MAPK14/MAP4K4/TGFBR2/AKT2/IGF2/RAC3/MAPKAPK5/TAB2/GNG12/RASA2/STK4/DUSP5/IKBKB/TNFRSF1A/MAP2K7/MAP4K3/PDGFA/TAOK2/PRKACB/ANGPT2/HRAS/ELK4/NFKB1/PDGFD/PDGFC/PPM1B/BDNF/RPS6KA4/MAP3K11/MAP2K3/MKNK1/PDGFB/RPS6KA3/SOS2/NTF4/PPP3CA	2.23014462156636
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	21/1784	70/9376	1.57668161434978	JUN/SLC2A1/MET/EPAS1/GAB1/EP300/KRAS/RAPGEF1/PIK3R1/CREBBP/PIK3CA/PIK3R3/AKT2/PIK3CB/PAK6/PTPN11/HRAS/TFE3/CDKN1A/PDGFB/SOS2	2.34751602153067
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	22/1784	75/9376	1.541644245142	MGST3/PMAIP1/ATP7B/ATM/REV3L/XIAP/MGST2/PDPK1/PIK3R1/ERBB2/PIK3CA/PIK3R3/AKT2/TOP2B/BIRC2/PIK3CB/XPA/SLC31A1/BCL2/MDM2/CDKN1A/BCL2L1	2.2828895822168
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	7/1784	16/9376	2.29932735426009	HEXA/HEXB/NAGA/GLA/GBGT1/A4GALT/B3GALNT1	2.52142243091084
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	21/1784	71/9376	1.55447483104907	FOS/PRLR/KRAS/SOCS7/SOCS1/PIK3R1/MAPK14/PIK3CA/PIK3R3/AKT2/GSK3B/SHC1/PIK3CB/FOXO3/HRAS/NFKB1/SOCS5/ELF5/STAT3/SOS2/IRF1	2.2733054148445
NA	NA	hsa04519	Cadherin signaling	93/1784	404/9376	1.20982995160503	EGFR/CDH1/MET/DSC3/GJA1/DSG2/GABRE/DSC2/LRP5/IGF1R/FAT1/NCSTN/TMC5/DSP/CTNND1/RERE/PCDH11X/ROCK1/ACTN4/ADAM10/TCF7L2/TEAD1/LATS2/DAAM1/VCL/FZD6/FZD5/TAOK1/TJP1/CDH3/EP300/AMOTL1/DVL3/NFKBIA/KRAS/RYK/NCKAP1/TAOK3/APH1A/TMC4/MYO7A/FZD3/ROCK2/ERBB2/MPDZ/AMOTL2/MYO1C/FZD10/CREBBP/MAPK14/TMC1/JUP/LRP6/TEAD3/APC/PSEN2/GSK3B/LIMA1/RAC3/CYFIP2/PSEN1/WNT4/CELSR2/PCDH11Y/ACTR2/IKBKB/ABI2/LATS1/YAP1/SAV1/ACTN1/WWC1/PKP2/KRT80/TAOK2/CIB2/HRAS/NFKB1/WWTR1/ARPC1B/LIMD1/DVL1/PCDHGC3/VAV3/MAP2K3/VANGL1/PRICKLE1/EVL/PTK2/ATN1/ARHGAP35/MOB1B/PKP3	2.08986625780936
Human Diseases	Cancer: specific types	hsa05214	Glioma	22/1784	76/9376	1.52135945244277	EGFR/GADD45B/IGF1R/CDK6/KRAS/CAMK2G/GADD45G/PIK3R1/PIK3CA/PIK3R3/AKT2/MTOR/SHC1/PIK3CB/PDGFA/MDM2/HRAS/POLK/CDKN1A/PTEN/PDGFB/SOS2	2.21211416769556
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	8/1784	20/9376	2.10224215246637	DHCR24/MSMO1/SQLE/LBR/LIPA/TM7SF2/SOAT1/SC5D	2.39194875040091
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	30/1784	112/9376	1.40775144138373	LAMA5/LAMB1/ITGA6/ITGB1/LAMC1/IL10RB/LAMB2/LDLR/IFNGR1/HSPA1B/NFKBIA/HSPA1A/XIAP/SOCS1/PDPK1/HSPA8/GNAI2/MAPK14/AKT2/BIRC2/TAB2/IKBKB/TNFRSF1A/BCL2/NFKB1/LAMB4/HLA-DRA/MAP2K3/STAT3/BCL2L1	2.10431236238879
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	34/1784	130/9376	1.37454294584339	EGFR/JUN/FOS/COL4A2/COL4A1/CREB3L2/ATF6B/NFKBIA/KRAS/TGFBR1/GNAI2/PIK3R1/ADCY6/MAPK14/TGFBR2/PIK3CA/PIK3R3/AKT2/ADCY7/PLCB1/SHC1/SMAD2/PIK3CB/GNG12/GNG11/CREB1/MAP2K7/PRKACB/HRAS/NFKB1/ADCY2/GNB4/SOS2/GNG5	2.08449720470632
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	17/1784	56/9376	1.59545163356823	LRP2/GLI3/PTCH2/FBXW11/GAS1/GSK3B/KIF3A/SPOP/BCL2/MEGF8/PRKACB/SPOPL/CSNK1G3/SMURF2/MGRN1/CUL1/IQCE	2.1663943376496
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	10/1784	28/9376	1.87700192184497	HACD3/HADHA/PPT1/ELOVL1/HSD17B12/THEM4/TECR/ELOVL4/PPT2/HACD2	2.25281314939331
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	24/1784	86/9376	1.46668057148816	EGFR/JUN/ERBB3/GAB1/KRAS/CAMK2G/PIK3R1/ERBB2/PIK3CA/PIK3R3/AKT2/GSK3B/MTOR/CBL/SHC1/PIK3CB/MAP2K7/PAK6/HRAS/ABL1/CBLB/CDKN1A/PTK2/SOS2	2.10749257471863
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	83/1784	362/9376	1.20501449347174	EGFR/CSF3R/HSP90B1/ITGB4/LAMA5/LAMB1/ITGAV/ITGA6/ITGB1/LAMC1/MET/COL4A2/FLT1/PKN2/PRLR/IGF1R/CDK6/ITGB5/FN1/COL4A1/CREB3L2/ITGB8/ERBB3/INSR/ATF6B/LAMB2/FGFR2/KRAS/PHLPP1/IL4R/EPHA2/MCL1/EFNA5/GHR/PDPK1/EFNA1/THEM4/ITGA3/PIK3R1/ERBB2/RXRA/G6PC3/PIK3CA/PIK3R3/AKT2/IGF2/GSK3B/MTOR/PIK3CB/GNG12/GNG11/IKBKB/FOXO3/CREB1/MAGI1/PDGFA/BCL2/PPP2R2D/MDM2/ANGPT2/HRAS/NFKB1/PDGFD/PDGFC/PRKAA1/BDNF/LAMB4/CDKN1A/PHLPP2/MLST8/PTK2/SGK3/RBL2/PTEN/GNB4/PDGFB/TSC1/TSC2/PPP2R3B/BCL2L1/SOS2/NTF4/GNG5	1.92834633357142
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	28/1784	105/9376	1.40149476831091	JUN/MUL1/ATG9A/HUWE1/CITED2/SIAH1/KRAS/AMFR/NBR1/USP8/SP1/RAB5B/ATG9B/RHOT2/FOXO3/MON1B/ARIH1/HRAS/TFE3/TBC1D17/FUNDC1/SMURF2/TFEB/TBC1D15/BCL2L1/BCL2L13/USP30/NLRX1	2.00547020020131
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	20/1784	70/9376	1.50160153747598	SLC2A1/IRS2/ACSL3/NFKBIA/CPT1A/PRKAB2/RXRA/G6PC3/AKT2/MTOR/APPL1/IKBKB/TNFRSF1A/PTPN11/RXRB/NFKB1/PPARA/PRKAA1/ADIPOR2/STAT3	2.04188518646802
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	12/1784	37/9376	1.70452066416192	CDH1/GADD45B/TPR/TCF7L2/KRAS/GADD45G/RXRA/HRAS/RXRB/POLK/NCOA4/CDKN1A	2.08137039851272
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	16/1784	54/9376	1.55721640923435	HES1/REV3L/REV1/TOP3A/ATR/TELO2/BRCA2/ERCC4/POLI/FANCM/POLK/RPA1/FANCF/USP1/FANCE/WDR48	1.99054129363605
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	13/1784	42/9376	1.62673499893231	TFRC/SLC3A2/SLC40A1/STEAP3/ACSL3/LPCAT3/SLC11A2/PCBP2/GCLM/PRNP/FTL/NCOA4/SAT2	1.97323885354376
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	37/1784	149/9376	1.30508321545731	EGFR/PLPP3/INSR/GNA12/GAB1/KRAS/PIK3R1/CYTH3/ADCY6/PIK3CA/DGKD/PIK3R3/AKT2/PIP5K1A/AGPAT1/ADCY7/AGPAT4/PLCB1/MTOR/SHC1/PIK3CB/AGPAT3/DGKH/PIP5K1C/PDGFA/PTPN11/HRAS/AGPAT5/PDGFD/PDGFC/PIP5K1B/ADCY2/DGKA/PDGFB/TSC1/TSC2/SOS2	1.81964283805689
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	24/1784	90/9376	1.40149476831091	EGFR/JUN/FOS/NFATC3/IFNGR1/NFKBIA/KRAS/PIK3R1/MAPK14/EML4/PIK3CA/PIK3R3/NFATC2/AKT2/MTOR/PIK3CB/IKBKB/PTPN11/HRAS/NFKB1/MAP2K3/PTEN/STAT3/PPP3CA	1.85520441486425
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	50/1784	212/9376	1.2395295710297	EGFR/CDH1/ITGB1/MET/FLT1/IGF1R/CTNND1/INSR/GNAQ/FGFR2/ID1/KRAS/RAPGEF1/PARD3/EPHA2/EFNA5/RAPGEF2/PRKCI/EFNA1/GNAI2/KRIT1/PIK3R1/ADCY6/MAPK14/PIK3CA/PIK3R3/AKT2/ADCY7/RAC3/PLCB1/PFN2/PIK3CB/TLN1/ADORA2B/MAGI1/PDGFA/ANGPT2/HRAS/PDGFD/PDGFC/TIAM1/RAPGEF6/VAV3/MAP2K3/MAGI3/EVL/ADCY2/PDGFB/PARD6B/PRKD2	1.70997393463241
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	18/1784	65/9376	1.45539841324595	PLPP3/PNPLA2/GLA/LIPG/DGKD/PLPP5/AGPAT1/GPAM/AGPAT4/LPIN1/DGAT1/LPIN2/AGPAT3/DGKH/GPAT4/AGK/AGPAT5/DGKA	1.78589117648934
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	22/1784	83/9376	1.39305202874277	SLC27A2/ACSL3/ABCD4/IDH1/SLC25A17/CAT/PEX1/PEX26/EPHX2/FAR1/PEX11B/CRAT/DHRS4/PEX14/GSTK1/HACL1/PEX16/PEX11A/NUDT19/ABCD1/MPV17L2/ABCD3	1.7434764413132
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	55/1784	238/9376	1.21453065531145	EGFR/MET/FLT1/IGF1R/NF1/RASA1/INSR/GAB1/FGFR2/KRAS/EPHA2/EFNA5/EFNA1/PIK3R1/PIK3CA/PIK3R3/AKT2/FOXO4/IGF2/RASAL2/KSR1/RAC3/RALGAPB/REL/RAB5B/RALGAPA1/SHC1/PIK3CB/GNG12/RASA2/STK4/GNG11/IKBKB/RALGAPA2/PDGFA/PAK6/PRKACB/ANGPT2/PTPN11/EXOC2/HRAS/ABL1/NFKB1/PDGFD/PDGFC/BDNF/TIAM1/GNB4/PDGFB/RALBP1/BCL2L1/ETS2/SOS2/NTF4/GNG5	1.62501444016559
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	20/1784	75/9376	1.40149476831091	LRP2/HSP90B1/HSPA5/PDIA4/CANX/CREB3L2/ATP1A1/GPX8/GNAQ/ITPR2/ATF6B/ADCY6/DUOX1/TTF1/ADCY7/PLCB1/CREB1/ATP1B3/PRKACB/ADCY2	1.69219599785692
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	50/1784	216/9376	1.21657531971433	JUN/HSP90B1/HSPA5/FOS/ATF6/ABCA1/DDIT3/LDLR/XBP1/NFATC3/HSPA1B/NFKBIA/HSPA1A/KRAS/MIB1/OLR1/CAMK2G/PDPK1/HSPA8/ROCK2/PIK3R1/MIB2/MAPK14/RXRA/PIK3CA/PIK3R3/NFATC2/AKT2/GSK3B/PLCB1/TAB2/PIK3CB/POU2F1/IKBKB/ERN1/TNFRSF1A/MAP2K7/BCL2/PYCARD/HRAS/RXRB/NFKB1/VAV3/MAP2K3/PTK2/IRF3/STAT3/NFE2L2/BCL2L1/PPP3CA	1.56096464428309
NA	NA	hsa04517	IgSF CAM signaling	67/1784	299/9376	1.1776774599937	CDH1/NRP2/APP/ITGB1/CADM1/IQGAP1/NRP1/MYH10/JAM3/PTPRF/ANK3/SPTBN1/SPTAN1/LMO7/RASA1/PLXNA1/ERC1/ACTN4/VCL/CNTNAP2/NLGN4X/TRIO/TJP1/F11R/SORBS1/PLXNA2/MTSS1/RDX/PARD3/RAPGEF2/SRGAP1/PDPK1/PRKCI/PPFIA1/PIK3R1/MPDZ/MAPK14/GRIP1/PIK3CA/BAIAP2/PIK3R3/TJP2/AKT2/GSK3B/EPB41L3/NRCAM/ROBO1/PIK3CB/EPB41L2/ACTR2/UNC5B/DYNLL2/PXN/ACTN1/WASL/MAGI1/PAK6/PTPN11/ABL1/ARPC1B/RAPGEF6/VAV3/CASK/PTK2/PARD6B/NLGN1/MYH9	1.51356726733858
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	17/1784	63/9376	1.41817922983842	GADD45B/GLI3/TCF7L2/PTCH2/FZD6/FZD5/DVL3/BMP4/GADD45G/FZD3/FZD10/APC/GSK3B/WNT4/POLK/DVL1/CDKN1A	1.61433214710075
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	22/1784	86/9376	1.34445719053082	ITGB4/ITGAV/DAG1/ITGA6/ITGB1/GJA1/DSG2/DSC2/ITGB5/DSP/ITGB8/ATP2A2/SSPN/TCF7L2/DMD/SGCE/ITGA3/JUP/PKP2/SGCB/SNTB1/SNTB2	1.55554144676998
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	5/1784	13/9376	2.02138668506382	PRKDC/RAD50/DCLRE1C/POLL/POLM	1.7863202439185
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	34/1784	142/9376	1.25838438703973	JUN/HSP90B1/ITGAV/FOS/CTSL/DUSP1/GPC1/MGST3/BMPR2/BMP4/ACVR2B/MGST2/PIK3R1/MAPK14/PIK3CA/ACVR2A/PIK3R3/BMPR1A/AKT2/RAC3/SUMO4/PIK3CB/IKBKB/TRPV4/TNFRSF1A/MAP2K7/PDGFA/BCL2/NFKB1/PRKAA1/PTK2/PDGFB/ACVR1/NFE2L2	1.5039052254361
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	19/1784	73/9376	1.36789729098839	RANBP2/SERINC3/AFF4/FURIN/EP300/CCNT1/HGS/CREBBP/CPSF7/BICD2/ELL/XPO1/SERINC5/NUP153/CHMP6/SUPT5H/NELFA/TNPO3/CCNT2	1.52961267259771
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	57/1784	253/9376	1.18406919654726	EGFR/JUN/ITGB1/DIAPH1/ROCK1/ACTN4/RPS6KA5/ITPR2/WASF2/VCL/ATM/NFKBIA/FBXW11/ROCK2/PIK3R1/CYTH3/MAPK14/PIK3CA/PIK3R3/AKT2/FOXO4/GSK3B/TAB3/PLCB1/PFN2/MTOR/ATG14/TAB2/WIPI2/PIK3CB/TLN1/ACTR2/IKBKB/NAIP/PXN/TNFRSF1A/FOXO3/DOCK1/ACTN1/HCLS1/WASL/BCL2/MDM2/PYCARD/WIPI1/NFKB1/CAPN1/ARPC1B/TECPR1/CUL1/FOXO6/PTK2/IRF3/ATG12/PIK3C3/RBCK1/BCL2L1	1.43872404964997
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	45/1784	196/9376	1.20664409261462	JUN/FOS/IL6ST/CDK6/TCF7L2/ITPR2/TLR3/NFATC3/IFNGR1/EP300/NFKBIA/KRAS/PIK3R1/HLA-E/CREBBP/MAPK14/PIK3CA/PIK3R3/NFATC2/AKT2/GSK3B/MTOR/ATG14/ZFP36/PIK3CB/GNG12/GNG11/IKBKB/TNFRSF1A/CREB1/MAP2K7/ANGPT2/HRAS/NFKB1/CDKN1A/IRF3/PIK3C3/EIF2AK2/STAT3/GNB4/PDGFB/PPP3CA/RCAN1/GNG5/HLA-C	1.41721145213063
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	33/1784	139/9376	1.24773365164371	EGFR/JUN/HSP90B1/FOS/CTSD/CREB3L2/NCOA3/GNAQ/ITPR2/ATF6B/HSPA1B/HSPA1A/KRAS/NCOA2/HSPA8/GNAI2/PIK3R1/ADCY6/PIK3CA/PIK3R3/AKT2/SP1/ADCY7/NCOA1/PLCB1/SHC1/PIK3CB/CREB1/BCL2/PRKACB/HRAS/ADCY2/SOS2	1.42636901505783
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	9/1784	30/9376	1.57668161434978	SLC19A1/FOLR1/MTR/SLC46A1/ABCC1/IKBKB/GGH/NFKB1/MTHFR	1.5335177531509
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	36/1784	155/9376	1.22065673369015	ITGAV/CTSL/ITGB1/DYNC1H1/TFRC/COLEC12/ATP6AP1/EEA1/CANX/ITGB5/CALR/SEC61A1/LAMP2/LAMP1/ATP6V1B1/ATP6V0A1/PLA2R1/HGS/OLR1/TCIRG1/HLA-E/ATP6V0B/PIKFYVE/RAB5B/DYNC1LI2/SCARB1/M6PR/ATP6V1C2/ATP6V1A/ATP6V0A2/HLA-DRA/ATP6V1E2/ATP6V1H/PIK3C3/DYNC1LI1/HLA-C	1.34276182835819
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	6/1784	18/9376	1.75186846038864	MTR/LMBRD1/ABCD4/HCFC1/CD320/ZNF76	1.54771703580462
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	12/1784	44/9376	1.43334692213616	DYNC1H1/CREB3L2/VAMP2/ADCY6/RAB5B/DYNC1LI2/DCTN1/DYNLL2/CREB1/DCTN5/PRKACB/DYNC1LI1	1.39662448943724
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/1784	31/9376	1.52582091711269	GLDC/ACSS1/ACO2/CAT/AMT/PCCA/CS/PGP/ACSS2	1.42145794704506
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	36/1784	157/9376	1.20510696638199	JUN/FOS/COX6A1/MT-CO2/INSR/MT-CO3/DDIT3/XBP1/MT-CYB/IRS2/NDUFB9/PIK3R1/CEBPA/MAPK14/PRKAB2/RXRA/PIK3CA/PIK3R3/AKT2/GSK3B/NDUFS1/PIK3CB/IKBKB/ERN1/TNFRSF1A/MT-CO1/NFKB1/PPARA/PRKAA1/ADIPOR2/MAP3K11/CYC1/NDUFB7/SREBF1/ITCH/NDUFA3	1.25629980827973
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	7/1784	23/9376	1.59953207252876	B4GAT1/B4GALT1/POMGNT1/POMT1/FKRP/FUT4/POMGNT2	1.39542286649559
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	10/1784	36/9376	1.4598903836572	GALNT11/C1GALT1C1/C1GALT1/B4GALT5/B3GNT3/GALNT1/GALNT6/GALNT7/GALNT18/GCNT4	1.34009968256181
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	12/1784	45/9376	1.40149476831091	ABCA1/ABCA5/ABCB1/ABCB8/ABCD4/ABCB10/ABCC1/ABCC10/ABCB7/ABCA12/ABCD1/ABCD3	1.30866056683806
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	26/1784	110/9376	1.24223399918467	EGFR/SLC2A1/TFRC/FLT1/IGF1R/INSR/EPAS1/IFNGR1/EP300/LTBR/CAMK2G/PIK3R1/ERBB2/CREBBP/PIK3CA/PIK3R3/AKT2/MTOR/PIK3CB/SERPINE1/BCL2/ANGPT2/NFKB1/CDKN1A/MKNK1/STAT3	1.23876879676202
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	37/1784	163/9376	1.19299017854687	JUN/FOS/ATP6AP1/DDB1/CREB3L2/ATF6B/TLR3/NFATC3/EP300/NFKBIA/KRAS/MAP3K1/TGFBR1/PIK3R1/MAVS/CREBBP/MAPK14/TGFBR2/PIK3CA/PIK3R3/NFATC2/AKT2/TAB2/PIK3CB/IKBKB/CREB1/MAP2K7/BCL2/HSPG2/SMAD4/HRAS/NFKB1/CDKN1A/MAP2K3/IRF3/STAT3/SOS2	1.20485126520958
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	15/1784	59/9376	1.33617085961845	ADRB1/INSR/IRS2/PNPLA2/GNAI2/PIK3R1/ADCY6/PDE3B/PIK3CA/PIK3R3/AKT2/ADCY7/PIK3CB/PRKACB/ADCY2	1.25560485489838
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/1784	15/9376	1.75186846038864	HEXA/GLB1/HEXB/SLC33A1/B3GALT4	1.41263947380584
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	27/1784	116/9376	1.22328745940931	ITGB1/CLDN4/JAM3/CTNND1/ROCK1/ACTN4/ARHGAP5/VCL/F11R/OCLN/GNAI2/ROCK2/PIK3R1/MAPK14/CLDN19/CLDN23/PIK3CA/PIK3R3/PIK3CB/CLDN3/PXN/ACTN1/PTPN11/CLDN7/VAV3/PTK2/ARHGAP35	1.17298591459771
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	51/1784	233/9376	1.15036855982602	FBN2/FBN1/ITGB4/ITGAV/FBLN1/DAG1/ITGA6/ITGB1/SYNE2/COL4A2/PLEC/DSG2/DSC2/MYH10/ANK3/SPTBN1/SPTAN1/ITGB5/FN1/DIAPH1/COL4A1/DSP/ITGB8/ATP1A1/SSPN/FMNL2/DIAPH2/SUN1/DAAM1/BGN/VCL/DMD/INF2/SGCE/LBR/ITGA3/COL5A2/SUN2/TMEM43/JUP/TLN1/TTN/FBLN2/ATP1B3/PKP2/NEB/SGCB/HSPG2/SNTB1/SNTB2/MYH9	1.12666707867651
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	54/1784	248/9376	1.14436568783451	JUN/AHNAK/HSP90B1/FOS/RHOB/DYNC1H1/GCC2/KIF5B/TCF7L2/MYO6/NFKBIA/NCKAP1/ROCK2/CYTH3/SNX18/MAPK14/PIK3CA/AKT2/GSDMD/RAB5B/DYNC1LI2/TAB3/BIRC2/CYFIP2/PFN2/PIK3C2A/TAB2/PIK3CB/ACTR2/FHOD1/DCTN1/IKBKB/DYNLL2/NAIP/TNFRSF1A/M6PR/MAP2K7/WASL/BCL2/DCTN5/ACBD3/VPS39/PYCARD/EXOC7/EXOC2/HRAS/NFKB1/VPS11/EXOC4/ARPC1B/MAP2K3/ACTR1B/PIK3C3/DYNC1LI1	1.1168811792292
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	35/1784	155/9376	1.18674960219876	EGFR/PBX1/CDK6/CREB3L2/KMT2A/GNAQ/TCF7L2/ITPR2/ATF6B/LDLR/FZD6/FZD5/DVL3/CAMK2G/GNA11/FZD3/GNAI2/NCEH1/ADCY6/FZD10/USP8/SP1/ADCY7/APC/GSK3B/WNT4/PLCB1/SCARB1/CREB1/PRKACB/KMT2D/DVL1/CDKN1A/MEN1/ADCY2	1.13642685224231
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	22/1784	93/9376	1.24326148801774	EGFR/JUN/EGR1/GNAQ/ITPR2/MMP14/MAP3K2/KRAS/MAP3K4/CAMK2G/MAP3K1/GNA11/ADCY6/MAPK14/ADCY7/PLCB1/MAP2K7/PRKACB/HRAS/MAP2K3/ADCY2/SOS2	1.14281418283131
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	40/1784	180/9376	1.16791230692576	PDIA3/CALR/TAPBP/TLR3/SRSF6/IFNGR1/SRSF5/NFKBIA/TAPBPL/NXF1/PIK3R1/HLA-E/MAVS/HCFC1/PIK3CA/PIK3R3/AKT2/B2M/SRSF7/BIRC2/MTOR/TAB2/PIK3CB/POU2F1/IKBKB/TNFRSF1A/BCL2/SRSF8/PILRB/PTPN11/NFKB1/HLA-DRA/IRF3/EIF2AK2/TSC1/TSC2/ZC3HAV1/BCL2L1/SRSF2/HLA-C	1.1026159312854
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	28/1784	122/9376	1.20620451371021	IGF1R/CREB3L2/INSR/HMGCR/FASN/IRS2/CPT1A/PDPK1/PIK3R1/PRKAB2/G6PC3/PIK3CA/PIK3R3/AKT2/MTOR/PIK3CB/FOXO3/CREB1/ACACA/PPP2R2D/PRKAA1/ADIPOR2/CAB39/RAB14/TSC1/TSC2/SREBF1/PPP2R3B	1.11126669549535
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	16/1784	65/9376	1.29368747844084	PBX1/CREB3L2/GNAQ/ITPR2/ATF6B/LDLR/GNA11/NCEH1/ADCY6/SP1/ADCY7/PLCB1/SCARB1/CREB1/PRKACB/ADCY2	1.15172530500153
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	44/1784	200/9376	1.1562331838565	JUN/FOS/ITGB1/CLDN4/MYH10/ROCK1/GNA12/WASF2/TMED10/MYO6/TJP1/NFKBIA/OCLN/NCKAP1/ARHGEF12/WIPF2/TMBIM6/ROCK2/CYTH3/MYO1C/SEC24D/MAPK14/CLDN19/CLDN23/BAIAP2/TAB3/CYFIP2/TAB2/CLDN3/ACTR2/IKBKB/NAIP/MYO5B/TNFRSF1A/HCLS1/WASL/PYCARD/PTPN11/ABL1/NFKB1/ARPC1B/CLDN7/SEC24B/MYH9	1.08259630926836
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	35/1784	156/9376	1.17914223295389	EGFR/CLDN4/CDK6/CD81/LDLR/TLR3/NFKBIA/KRAS/OCLN/CFLAR/PIK3R1/PIAS1/MAVS/CLDN19/CLDN23/RXRA/PIK3CA/PIK3R3/AKT2/GSK3B/SCARB1/PIK3CB/CLDN3/IKBKB/TNFRSF1A/PPP2R2D/HRAS/NFKB1/PPARA/CLDN7/CDKN1A/IRF3/EIF2AK2/STAT3/SOS2	1.09370396212763
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	9/1784	33/9376	1.43334692213616	OGDH/ACO2/IDH1/DHTKD1/GOT2/DBT/GOT1/CS/BCAT1	1.20880006683241
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	24/1784	103/9376	1.22460707910662	JUN/FOS/CALR/GNAQ/IFNGR1/NFKBIA/TGFBR1/GNA11/GNAI2/CFLAR/PIK3R1/MAPK14/TGFBR2/PIK3CA/PIK3R3/AKT2/PLCB1/SMAD2/PIK3CB/IKBKB/TNFRSF1A/SERPINE1/PPP2R2D/NFKB1	1.11105839731289
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	21/1784	89/9376	1.24008666297173	EGFR/GJA1/ADRB1/GNAQ/ITPR2/TJP1/MAP3K2/KRAS/GNA11/GNAI2/ADCY6/ADCY7/PLCB1/PDGFA/PRKACB/HRAS/PDGFD/PDGFC/ADCY2/PDGFB/SOS2	1.10313910307884
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1784	12/9376	1.75186846038864	GGCX/COQ4/COQ2/VKORC1L1	1.26330074225296
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	24/1784	105/9376	1.20128122998078	JUN/ITPR2/NFATC3/NFKBIA/KRAS/ARHGEF12/PIK3R1/MAPK14/PIK3CA/PIK3R3/NFATC2/AKT2/KSR1/PIK3CB/IKBKB/MDM2/PYCARD/PTPN11/HRAS/NFKB1/CBLB/CYLD/PPP3CA/IRF1	1.00540166509401
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	81/1784	388/9376	1.09717535019185	LRP1/SLC39A10/APP/COX6A1/MT-CO2/LRP5/MT-ND3/MME/NCSTN/RTN4/MT-ND6/SLC39A7/ATF6/KIF5B/INSR/ATP2A2/RB1CC1/GNAQ/ADAM10/MT-CO3/ITPR2/DDIT3/ADAM17/SLC39A1/XBP1/FZD6/FZD5/MT-CYB/IRS2/PSMD1/DVL3/KRAS/APH1A/SLC11A2/NDUFB9/FZD3/PIK3R1/FZD10/PIK3CA/APOE/PIK3R3/AKT2/LRP6/ATG2B/APC/PSEN2/GSK3B/SLC39A3/NDUFS1/ATG2A/SLC39A13/PSEN1/WNT4/PLCB1/MTOR/ATG14/WIPI2/MT-ND1/PIK3CB/IKBKB/FRAT2/ERN1/MT-ND4/TNFRSF1A/PSMD3/MAP2K7/MT-CO1/HRAS/IDE/WIPI1/NFKB1/CAPN1/DVL1/PIK3C3/EIF2AK2/SLC39A6/CYC1/NDUFB7/NRBF2/NDUFA3/PPP3CA	0.947644418060994
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	32/1784	144/9376	1.16791230692576	ATP2A2/RB1CC1/GNAQ/PUM2/ITPR2/PUM1/XBP1/PSMD1/ATXN2/PIK3R1/RBPJ/PIK3CA/PIK3R3/AKT2/ATG2B/SP1/ATG2A/PLCB1/MTOR/ATG14/WIPI2/PIK3CB/OMA1/ATXN1/AFG3L2/ERN1/PSMD3/WIPI1/ATXN1L/PIK3C3/NOP56/NRBF2	0.98428493949984
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	21/1784	91/9376	1.21283201103829	JUN/FOS/CD81/NFATC3/NFKBIA/KRAS/INPPL1/PIK3R1/PIK3CA/PIK3R3/NFATC2/AKT2/GSK3B/RAC3/PIK3CB/IKBKB/HRAS/NFKB1/VAV3/SOS2/PPP3CA	0.988943896167887
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	23/1784	101/9376	1.19682102739422	CREB3L2/GNAQ/TCF7L2/FZD6/FZD5/EP300/DVL3/KRAS/CAMK2G/FZD3/GNAI2/ADCY6/FZD10/CREBBP/ADCY7/GSK3B/WNT4/PLCB1/CREB1/PRKACB/HRAS/DVL1/ADCY2	0.964006996103537
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	23/1784	101/9376	1.19682102739422	JUN/COL4A2/EGR1/FN1/DIAPH1/COL4A1/KRAS/TGFBR1/PIK3R1/MAPK14/TGFBR2/PIK3CA/PIK3R3/AKT2/PLCB1/SMAD2/PIK3CB/SERPINE1/BCL2/SMAD4/HRAS/NFKB1/STAT3	0.964006996103537
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	31/1784	140/9376	1.16374119154388	CDH1/EGR1/SLC9A1/JAG1/NOTCH3/GNAQ/ITPR2/KRAS/TGFBR1/GNAI2/ADCY6/PDE3B/PRKAB2/AKT2/ADCY7/PLCB1/MTOR/SMAD2/GNG12/TFAM/GNG11/APELA/SERPINE1/PRKACB/SMAD4/HRAS/PRKAA1/PIK3C3/ADCY2/GNB4/GNG5	0.946204405219305
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	44/1784	205/9376	1.12803237449415	JUN/IL6ST/CDK6/DDB1/CREB3L2/DLG1/ACTN4/UBR4/ATF6B/PMAIP1/SCIN/CHD4/EP300/NFKBIA/KRAS/LTBR/PIK3R1/UBE3A/HLA-E/CREBBP/RBPJ/PIK3CA/PIK3R3/SCRIB/REL/PIK3CB/RASA2/USP7/PXN/HDAC7/CREB1/ACTN1/MDM2/PRKACB/HRAS/NFKB1/HDAC11/CDKN1A/HDAC2/IRF3/RBL2/EIF2AK2/STAT3/HLA-C	0.898448829712587
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/1784	68/9376	1.23661303086257	DUSP6/TCF7L2/KRAS/PIK3R1/CEBPA/PIK3CA/PIK3R3/AKT2/JUP/MTOR/PIK3CB/IKBKB/HRAS/NFKB1/STAT3/SOS2	0.949226580994762
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	24/1784	107/9376	1.17882737521479	SLC2A1/CREB3L2/GNAQ/ITPR2/PHKB/EP300/CPT1A/CAMK2G/CREBBP/PDE3B/PRKAB2/G6PC3/PPP4R3A/AKT2/PLCB1/CREB1/ACACA/PHKA2/PRKACB/PPARA/PRKAA1/ADCY2/PYGB/PPP3CA	0.901808684735245
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	27/1784	122/9376	1.1631257810777	JUN/FOS/DLG1/NFATC3/NFKBIA/KRAS/PDPK1/PIK3R1/MAPK14/PIK3CA/PIK3R3/NFATC2/AKT2/GSK3B/PIK3CB/IKBKB/MAP2K7/PAK6/PPP2R2D/PTPN11/HRAS/NFKB1/CBLB/VAV3/PPP2R3B/SOS2/PPP3CA	0.879109018646767
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	21/1784	93/9376	1.18674960219876	JUN/FOS/JAG1/NOTCH3/MAML2/GATA3/MAML3/NFATC3/IFNGR1/NFKBIA/IL4R/MAPK14/RBPJ/NFATC2/NOTCH2/IKBKB/JAG2/MAML1/NFKB1/HLA-DRA/PPP3CA	0.877327914788042
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	20/1784	89/9376	1.18103491711594	ITGB4/LAMA5/LAMB1/ITGAV/DAG1/ITGA6/ITGB1/LAMC1/COL4A2/FRAS1/ITGB5/FN1/COL4A1/ITGB8/LAMB2/CD47/FREM2/ITGA3/HSPG2/LAMB4	0.831810870380334
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	25/1784	115/9376	1.14252290894911	FOS/CREB3L2/GNAQ/ITPR2/KRAS/CAMK2G/GNA11/GNAI2/PIK3R1/ADCY6/PIK3CA/PIK3R3/AKT2/ADCY7/PLCB1/PIK3CB/GNG12/GNG11/CREB1/BCL2/PRKACB/HRAS/ADCY2/GNB4/GNG5	0.745434724327377
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/1784	23/9376	1.37102749073894	PCYOX1/HMGCR/ZMPSTE24/RCE1/NUS1/ICMT	0.863573891037761
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	6/1784	23/9376	1.37102749073894	ENPEP/CTSA/MME/ATP6AP2/LNPEP/PRCP	0.863573891037761
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	16/1784	71/9376	1.18436177603739	EGFR/SLC2A1/MET/SLC1A5/FGFR2/KRAS/PIK3R1/ERBB2/IDH1/PIK3CA/PIK3R3/AKT2/MTOR/PIK3CB/HRAS/PTEN	0.755869518843955
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1784	14/9376	1.50160153747598	FUT8/B3GNT2/B4GALT1/B4GALT4	0.910423631384212
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/1784	28/9376	1.31390134529148	ATP6V1B1/ATP6V0A1/TCIRG1/ATP6V1C2/ATP6V1A/ATP6V0A2/ATP6V1E2	0.806339257270068
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	47/1784	227/9376	1.08816499081409	EGFR/JUN/SLC26A2/FOS/MET/COX6A1/MT-CO2/MT-ND3/MGST3/MT-ND6/MT-CO3/MT-CYB/NFKBIA/KRAS/NDUFB9/MGST2/PDPK1/PIK3R1/MAPK14/EPHX1/PIK3CA/PIK3R3/PTPRJ/AKT2/NDUFS1/CAT/EPHX2/MT-ND1/PIK3CB/CBR1/IKBKB/MT-ND4/FOXO3/MAP2K7/MT-CO1/PTPN11/HRAS/ABL1/NFKB1/PTK2/PTEN/CYC1/NDUFB7/PRKD2/NFE2L2/SOS2/NDUFA3	0.651819344089206
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1784	19/9376	1.38305404767524	GLDC/OGDH/DHTKD1/DBT/AMT	0.810165051878454
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	9/1784	38/9376	1.24474864290772	ATP1A1/INSR/KRAS/PDPK1/PIK3R1/PIK3CA/PIK3R3/PIK3CB/ATP1B3	0.732807860910388
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	30/1784	142/9376	1.11033916503505	JUN/FOS/FOSB/JUND/JUNB/ATP2A2/ITPR2/IFNGR1/NFKBIA/TGFBR1/SOCS1/PIK3R1/MAPK14/TGFBR2/PIK3CA/PIK3R3/NFATC2/SIRPA/AKT2/TAB2/PIK3CB/TMEM64/IKBKB/TNFRSF1A/CREB1/MAP2K7/ACP5/NFKB1/CYLD/PPP3CA	0.642220099935682
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	12/1784	53/9376	1.18994838818851	ATP2B1/ATP2B4/ATP1A1/CLTC/GNAQ/AP2A2/ADCY6/AP2A1/AP2B1/PLCB1/ATP1B3/PRKACB	0.672203344423372
Organismal Systems	Digestive system	hsa04970	Salivary secretion	20/1784	93/9376	1.13023771637977	ATP2B1/KCNN4/ATP2B4/SLC9A1/ATP1A1/ADRB1/SLC4A2/GNAQ/TRPV6/ITPR2/VAMP2/CST3/ADCY6/ADCY7/PLCB1/SLC12A2/BST1/ATP1B3/PRKACB/ADCY2	0.611841646744772
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	22/1784	103/9376	1.12255648918107	LAMA5/LAMB1/LAMC1/COL4A2/FN1/COL4A1/ACTN4/GNAQ/LAMB2/VCL/GNA11/PIK3R1/PIK3CA/PIK3R3/RAB5B/PLCB1/PIK3CB/ACTN1/PRKACB/NFKB1/LAMB4/PTK2	0.606247216211628
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	8/1784	34/9376	1.23661303086257	POLR2J3/POLR2A/POLR2B/POLR3A/POLR1A/POLR3E/POLR2J2/POLR3B	0.669982021971103
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	8/1784	34/9376	1.23661303086257	BHLHE41/FBXW11/CLOCK/PRKAB2/NR1D2/CREB1/PRKAA1/CUL1	0.669982021971103
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	17/1784	79/9376	1.13095305670659	SLC6A4/CLTC/SLC1A3/ATP6V1B1/VAMP2/ATP6V0A1/AP2A2/TCIRG1/ATP6V0B/AP2A1/AP2B1/ATP6V1C2/ATP6V1A/ATP6V0A2/ATP6V1E2/ATP6V1H/SYT1	0.566581948798152
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	11/1784	50/9376	1.1562331838565	ALDH18A1/OAT/ALDH4A1/GOT2/PYCR2/AMD1/CKMT1B/MAOA/GOT1/SAT2/AOC1	0.53692737076015
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/1784	70/9376	1.12620115310698	DAG1/EIF4G1/CD55/SSPN/DMD/SGCE/HLA-E/EIF4G3/RAC3/SGCB/ABL1/SNTB1/HLA-DRA/SNTB2/HLA-C	0.51373101115479
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	13/1784	60/9376	1.13871449925262	KRAS/PIK3R1/MAPK14/PIK3CA/PIK3R3/NFATC2/AKT2/RAC3/PIK3CB/PXN/HRAS/PTK2/PPP3CA	0.52250169930884
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/1784	21/9376	1.25133461456331	CSAD/AASDHPPT/PANK3/COASY/BCAT1	0.558914040937753
Organismal Systems	Digestive system	hsa04978	Mineral absorption	13/1784	61/9376	1.1200470484452	ATP2B1/ATP2B4/SLC40A1/ATP1A1/TRPV6/ATP7B/SLC46A1/TRPM7/SLC11A2/FTL/SLC34A2/SLC31A1/ATP1B3	0.455963352396126
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	34/1784	168/9376	1.06363442237882	EGFR/CSF3R/IL6ST/PRLR/IL10RB/IFNGR1/EP300/IL4R/LIFR/CSF2RA/MCL1/SOCS7/GHR/SOCS1/PIK3R1/PIAS1/CREBBP/PIK3CA/PIK3R3/AKT2/MTOR/IL11RA/PIK3CB/PDGFA/BCL2/PTPN11/HRAS/SOCS5/CDKN1A/STAT3/PDGFB/IL15RA/BCL2L1/SOS2	0.403430803641886
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	12/1784	56/9376	1.12620115310698	HSPA1B/SAR1B/NFKBIA/HSPA1A/CLK1/HSPA8/CLK4/NAIP/PYCARD/NFKB1/RAB1B/BCL2L13	0.459149741277
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	9/1784	41/9376	1.15366947391447	EGFR/CDH1/RPS6KA5/KRAS/ERBB2/DAPK1/MDM2/HRAS/CDKN1A	0.477999382091111
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	47/1784	235/9376	1.05112107623318	COX6A1/MT-CO2/MT-ND3/MT-ND6/ARID1A/CREB3L2/MT-CO3/MT-CYB/SMARCA2/CPT2/ACSL3/KRAS/SMARCC1/CPT1A/SMARCA4/PNPLA2/NDUFB9/COX19/SMARCD2/ADCY6/MAPK14/PRKAB2/ADCY7/NDUFS1/SLC25A29/ARID1B/MTOR/MT-ND1/KDM3B/MT-ND4/CREB1/FRS2/PRKACB/MT-CO1/HRAS/PRKAA1/MAP2K3/MLST8/SMARCD1/ADCY2/TSC1/TSC2/RPS6KA3/CYC1/NDUFB7/SOS2/NDUFA3	0.384717576672753
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	17/1784	82/9376	1.08957672536367	HSPA5/CTSL/PDIA3/LGMN/CANX/CALR/TAPBP/HSPA1B/HSPA1A/TAPBPL/HSPA8/HLA-E/B2M/CTSB/CREB1/HLA-DRA/HLA-C	0.394916916706361
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	29/1784	144/9376	1.05842052815147	TRA2B/TCF7L2/FASN/NFKBIA/CPT1A/ACADVL/MAPK14/PRKAB2/AKT2/TRA2A/GSK3B/TAB3/LPIN1/TAB2/LPIN2/IL17RA/IKBKB/TNFRSF1A/FOXO3/MAP2K7/ACACA/NFKB1/IL17RC/PPARA/PRKAA1/ADIPOR2/MAP2K3/IRF3/SREBF1	0.342455220048535
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	20/1784	98/9376	1.07257252676856	ATP2B1/ATP2B4/CREB3L2/ATP1A1/GNAQ/ITPR2/ATF6B/LDLR/CAMK2G/GNA11/ADCY6/ADCY7/PLCB1/SCARB1/CREB1/ATP1B3/PRKACB/DAGLB/ADCY2/PRKD2	0.350076583157639
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	7/1784	32/9376	1.14966367713004	ACSS1/HADHA/ACADS/DBT/ACACA/PCCA/ACSS2	0.411083408769991
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1784	32/9376	1.14966367713004	PMAIP1/BIRC6/XIAP/BIRC2/TNFRSF1A/BCL2/BCL2L1	0.411083408769991
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/1784	27/9376	1.16791230692576	HACD3/ELOVL1/HSD17B12/TECR/ELOVL4/HACD2	0.42353255101494
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	22/1784	109/9376	1.06076438885918	JUN/FOS/IL6ST/GATA3/NFATC3/IFNGR1/NFKBIA/IL4R/TGFBR1/MAPK14/TGFBR2/RXRA/NFATC2/MTOR/SMAD2/IKBKB/SMAD4/RXRB/NFKB1/HLA-DRA/STAT3/PPP3CA	0.309312709490553
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	13/1784	63/9376	1.08448999928821	POLR2J3/DDB1/POLR2A/XPC/POLR2B/ERCC4/XPA/POLR2J2/RPA1/UVSSA/RFC1/MNAT1/ERCC5	0.326163788699335
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	10/1784	48/9376	1.0949177877429	ATP1A1/PIK3R1/G6PC3/PIK3CA/PIK3R3/AKT2/PLCB1/PIK3CB/ATP1B3/SLC37A4	0.31957950594393
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	21/1784	105/9376	1.05112107623318	GADD45B/ERC1/ATM/PPP1R13L/NFKBIA/LTBR/XIAP/GADD45G/CFLAR/PLAU/PARP1/TAB3/BIRC2/TAB2/IKBKB/TNFRSF1A/BCL2/PIDD1/NFKB1/BCL2L1/CYLD	0.255350263763533
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	21/1784	105/9376	1.05112107623318	ITGB4/ITGAV/DAG1/ITGA6/ITGB1/ITGB5/ITGB8/ADRB1/ATP2A2/SSPN/DMD/SGCE/ITGA3/ADCY6/ADCY7/TTN/PRKACB/SGCB/SNTB1/ADCY2/SNTB2	0.255350263763533
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	14/1784	69/9376	1.06635471501917	KRAS/PDPK1/PIK3R1/MAPK14/PIK3CA/PIK3R3/AKT2/RAC3/PIK3CB/MAP2K7/HRAS/VAV3/MAP2K3/SOS2	0.268161508631075
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	11/1784	54/9376	1.07058628134861	MTR/DNMT3A/AHCYL1/MAT2A/GCLM/GOT2/AMD1/GOT1/SDSL/MRI1/BCAT1	0.252155007390558
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	40/1784	205/9376	1.02548397681286	JUN/GADD45B/PDIA3/CDK6/CALR/TAPBP/HES1/PSMD1/NFKBIA/TAPBPL/GADD45G/SIN3A/PIK3R1/HLA-E/MAVS/MAPK14/RBPJ/PIK3CA/PIK3R3/AKT2/B2M/TAB2/PIK3CB/IKBKB/USP7/PSMD3/MAP2K7/BCL2/MDM2/NEDD4/NFKB1/POLK/CDKN1A/HLA-DRA/MAP2K3/HDAC2/IRF3/EIF2AK2/STAT3/HLA-C	0.178830153188991
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	40/1784	205/9376	1.02548397681286	SLC2A1/CTSD/COX6A1/MT-CO2/MT-ND3/MT-ND6/INSR/ATP2A2/MT-CO3/MT-CYB/CPT2/CAMK2G/NDUFB9/TGFBR1/PIK3R1/MAPK14/TGFBR2/PIK3CA/PIK3R3/AKT2/SP1/GSK3B/PARP1/NDUFS1/PLCB1/PDK2/MTOR/MT-ND1/SMAD2/PIK3CB/MT-ND4/PDK4/MT-CO1/NFKB1/PPARA/PTEN/CYC1/NDUFB7/GFPT1/NDUFA3	0.178830153188991
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	10/1784	49/9376	1.07257252676856	JUN/FOSB/CREB3L2/ATF6B/GNAI2/CREB1/MAOA/PRKACB/NFKB1/BDNF	0.246890431879932
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	9/1784	44/9376	1.07501019160212	GTF2I/TAF3/TAF4B/TAF1/TAF2/TAF11/TAF8/TAF5L/MNAT1	0.241748735706917
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	9/1784	44/9376	1.07501019160212	TDG/NEIL1/PNKP/PARP1/MBD4/POLL/RFC1/MUTYH/POLG	0.241748735706917
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	17/1784	86/9376	1.03889873813745	SLC2A1/KCNN4/CREB3L2/ATP1A1/GNAQ/ATF6B/PCLO/VAMP2/CAMK2G/GNA11/ADCY6/ADCY7/PLCB1/CREB1/ATP1B3/PRKACB/ADCY2	0.175663626898335
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	15/1784	76/9376	1.03729053575643	SLC27A2/CPT2/ACSL3/SORBS1/CPT1A/OLR1/PDPK1/RXRA/SLC27A6/SLC27A4/ANGPTL4/RXRB/PPARA/ME1/ACADL	0.158222742641874
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	70/1784	368/9376	0.999707545330474	HSPA5/COX6A1/MT-CO2/FUS/MT-ND3/TPR/MT-ND6/RANBP2/ATF6/KIF5B/RB1CC1/GPX8/MT-CO3/DDIT3/XBP1/MT-CYB/POM121C/PSMD1/ATXN2/POM121/NXF1/NDUFB9/NUP210/C9orf72/MAPK14/ATG2B/SRSF7/SETX/NDUFS1/SPG11/CAT/CCS/ATG2A/PFN2/MTOR/NUP153/ATG14/WIPI2/MT-ND1/DERL1/NUP214/DCTN1/NUP107/ERN1/MT-ND4/TNFRSF1A/PSMD3/SIGMAR1/NUP133/NUP188/BCL2/DCTN5/NUP205/MT-CO1/NUP155/NDC1/WIPI1/NUP160/MAP2K3/ACTR1B/ALS2/NUP98/PIK3C3/NUP58/CYC1/NDUFB7/BCL2L1/NRBF2/NDUFA3/PPP3CA	-0.00277442662836491
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	18/1784	94/9376	1.00639251979773	JUN/HSP90B1/FOS/FOSB/JUND/NFKBIA/TRAF4/USP25/MAPK14/GSK3B/TAB3/TAB2/IL17RA/IKBKB/MAPK6/S100A8/NFKB1/IL17RC	0.030193967968296
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	8/1784	41/9376	1.02548397681286	RAD50/ATM/TOPBP1/TOP3A/BRCA2/RPA1/RBBP8/RAD51D	0.0792696484179567
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	7/1784	36/9376	1.02192326856004	MCM6/MCM2/MCM5/RPA1/RFC1/MCM3/MCM7	0.0638834084861535
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/1784	47/9376	1.00639251979773	INSR/IRS2/SOCS1/PIK3R1/PIK3CA/PIK3R3/MTOR/PIK3CB/IKBKB	0.0212965094653849
NA	NA	hsa04981	Folate transport and metabolism	6/1784	31/9376	1.01721394474179	SLC19A1/FOLR1/MTR/SLC46A1/ABCC1/MTHFR	0.04653466181523
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	7/1784	37/9376	0.99430372076112	RIMKLB/ALDH4A1/GOT2/GOT1/GLUD1/CAD/GFPT1	-0.0168285581851192
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	9/1784	48/9376	0.98542600896861	HADHA/ACADS/MCCC2/DBT/PCCA/MCCC1/IVD/ACADSB/BCAT1	-0.0490692942197373
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	8/1784	43/9376	0.977787047658776	CPT2/HADHA/ACSL3/CPT1A/ACADVL/ACADS/ACADL/ACADSB	-0.0707676612570559
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	12/1784	65/9376	0.970265608830631	KCNN4/GNAQ/ITPR2/KRAS/GNA11/PIK3R1/PIK3CA/PIK3R3/AKT2/PLCB1/PIK3CB/HRAS	-0.11660643797408
Human Diseases	Infectious disease: viral	hsa05162	Measles	25/1784	136/9376	0.966103930361382	JUN/CD46/FOS/CDK6/HSPA1B/ADAR/NFKBIA/HSPA1A/HSPA8/PIK3R1/MAVS/PIK3CA/PIK3R3/AKT2/GSK3B/TAB2/PIK3CB/IKBKB/BCL2/NFKB1/CBLB/IRF3/EIF2AK2/STAT3/BCL2L1	-0.193013539674023
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1784	16/9376	0.98542600896861	GOT2/MAOA/GOT1	-0.028281701123245
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	40/1784	217/9376	0.968775185468372	EGFR/JUN/HSP90B1/FOS/MGST3/CREB3L2/ADRB1/JAG1/ATF6B/KPNB1/KRAS/XIAP/MGST2/GNAI2/KPNA6/PIK3R1/ADCY6/KLF5/EPHX1/RXRA/PIK3CA/PIK3R3/AKT2/ADCY7/NOTCH2/MTOR/EPHX2/PIK3CB/CREB1/BCL2/PRKACB/HRAS/RXRB/NFKB1/PPARA/PAQR7/ADCY2/STAT3/RPS6KA3/SOS2	-0.225585233732292
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	57/1784	308/9376	0.972628268592394	COX6A1/POLR2J3/MT-CO2/MT-ND3/MT-ND6/CREB3L2/KIF5B/RB1CC1/GPX8/CLTC/SLC1A3/GNAQ/MT-CO3/POLR2A/MT-CYB/REST/PSMD1/AP2A2/EP300/NDUFB9/SIN3A/RCOR1/TAF4B/CREBBP/TGM2/AP2A1/ATG2B/SP1/POLR2B/NDUFS1/AP2B1/ATG2A/PLCB1/MTOR/ATG14/WIPI2/MT-ND1/HTT/TFAM/DCTN1/ERN1/MT-ND4/CREB1/PSMD3/MAP2K7/DCTN5/MT-CO1/POLR2J2/WIPI1/BDNF/ACTR1B/HDAC2/PIK3C3/CYC1/NDUFB7/NRBF2/NDUFA3	-0.236770088100951
Organismal Systems	Immune system	hsa04611	Platelet activation	23/1784	126/9376	0.959356537831874	ITGB1/ROCK1/GNAQ/ITPR2/PPP1R12A/STIM1/ARHGEF12/PRKCI/GNAI2/ROCK2/PIK3R1/ADCY6/MAPK14/PIK3CA/PIK3R3/AKT2/ADCY7/PLCB1/PIK3CB/TLN1/PRKACB/ARHGAP35/ADCY2	-0.22264352300214
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	18/1784	99/9376	0.95556461475744	ITGB4/ITGAV/DAG1/ITGA6/ITGB1/ITGB5/ITGB8/ATP2A2/SSPN/DMD/SGCE/ITGA3/PRKAB2/TTN/SGCB/PRKAA1/SNTB1/SNTB2	-0.21545061208915
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	30/1784	166/9376	0.949808201415528	ATP2B1/ATP2B4/CREB3L2/ATP1A1/ADRB1/INSR/ROCK1/ATP2A2/GNAQ/ITPR2/ATF6B/GNA12/GTF2I/NFATC3/PPP1R12A/IRS2/GNA11/GNAI2/ROCK2/ADCY6/PDE3B/NFATC2/AKT2/ADCY7/PLCB1/CREB1/RGS2/ATP1B3/ADCY2/PPP3CA	-0.316272878319458
Organismal Systems	Digestive system	hsa04976	Bile secretion	16/1784	90/9376	0.934329845540608	SLC2A1/SLC9A1/ATP1A1/HMGCR/SLC4A2/LDLR/ABCB1/NCEH1/ADCY6/EPHX1/RXRA/ADCY7/SCARB1/ATP1B3/PRKACB/ADCY2	-0.303444951450867
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1784	23/9376	0.91401832715929	GOT2/GOT1/GLUD1/CAD	-0.200124059877905
Genetic Information Processing	Transcription	hsa03040	Spliceosome	44/1784	243/9376	0.951632250087656	SF1/FUS/PRPF38B/RBM25/TRA2B/THOC2/SF3B1/SRSF6/DDX39B/SRSF5/HSPA1B/PRPF8/DDX46/TCERG1/HSPA1A/HSPA8/U2SURP/TRA2A/SNRNP200/SRSF7/DDX42/PRPF40A/AQR/DDX5/SRSF10/CHERP/SF3A1/LSM8/CCDC12/SF3B3/CWC25/SRSF8/RBMXL1/DHX8/SF3A2/PRPF6/ACIN1/CDC40/GPKOW/PRPF40B/DHX15/ISY1/USP39/SRSF2	-0.370303021569287
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/1784	52/9376	0.909624008278717	IGF1R/INSR/LDLR/ADCY6/ADCY7/SCARB1/HSD17B1/PRKACB/ADCY2	-0.316780601326494
NA	NA	hsa04382	Cornified envelope formation	39/1784	217/9376	0.944555805831663	ITGB4/LAMA5/ITGA6/CLDN4/COL4A2/PLEC/DSG2/DST/PRSS8/ST14/COL4A1/DSP/FURIN/ELOVL1/TJP1/OCLN/KDSR/CLDN19/SPTLC3/CLDN23/SPTLC2/JUP/ELOVL4/UGCG/EPHX2/CLDN3/PCSK6/GBA2/ABCA12/SLC27A4/PPP2R2D/PKP2/KRT80/S100A8/SPTLC1/CAPN1/CLDN7/PPP2R3B/PKP3	-0.400559352815182
Organismal Systems	Endocrine system	hsa04924	Renin secretion	12/1784	69/9376	0.91401832715929	ADRB1/GNAQ/ITPR2/GNAI2/ADCY6/PDE3B/PLCB1/CTSB/CREB1/CLCA2/PRKACB/PPP3CA	-0.347480583662011
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1784	18/9376	0.87593423019432	FASN/ACSL3/ACACA	-0.255388695768953
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1784	12/9376	0.87593423019432	CD46/NPC1	-0.208457180133193
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/1784	30/9376	0.87593423019432	OGDH/ACO2/IDH1/PC/CS	-0.329916986810588
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	17/1784	98/9376	0.911686647753272	PLPP3/SCIN/WASF2/INPPL1/LIMK2/PIK3R1/PIK3CA/PIK3R3/AKT2/PIP5K1A/PIK3CB/ACTR2/PIP5K1C/DOCK1/ARPC1B/VAV3/PIP5K1B	-0.426007443565096
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	13/1784	76/9376	0.898985130988907	SLC9A1/ATP1A1/SLC4A2/GNAQ/ITPR2/CAMK2G/GNAI2/ADCY6/ADCY7/PLCB1/ATP1B3/PRKACB/ADCY2	-0.428603378802037
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	19/1784	110/9376	0.907786384019568	IGF1R/KRAS/GNAI2/PIK3R1/ADCY6/MAPK14/PDE3B/PIK3CA/PIK3R3/CPEB4/AKT2/ADCY7/PIK3CB/ANAPC1/PRKACB/ANAPC4/CDC23/ADCY2/RPS6KA3	-0.47157438880439
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	34/1784	193/9376	0.925857942796069	ROCK1/GNAQ/NFKBIA/KRAS/PARD3/GNAI2/ROCK2/PIK3R1/ADCY6/PIK3CA/PIK3R3/AKT2/ADCY7/GSK3B/RAC3/PLCB1/SHC1/PIK3CB/GNG12/GNG11/IKBKB/PXN/FOXO3/PRKACB/HRAS/NFKB1/TIAM1/VAV3/PTK2/ADCY2/STAT3/GNB4/SOS2/GNG5	-0.504493944821399
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	24/1784	138/9376	0.91401832715929	COX6A1/MT-CO2/ATP6AP1/MT-ND3/MT-ND6/MT-CO3/ATP6V1B1/MT-CYB/ATP6V0A1/NDUFB9/TCIRG1/ATP6V0B/NDUFS1/MT-ND1/MT-ND4/ATP6V1C2/MT-CO1/ATP6V1A/ATP6V0A2/ATP6V1E2/ATP6V1H/CYC1/NDUFB7/NDUFA3	-0.493243553789795
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	20/1784	116/9376	0.90613885882171	GLDC/ACSS1/ADPGK/OGDH/ACO2/H6PD/IDH1/ACADS/CAT/GOT2/PC/GOT1/GLUD1/AMT/SDSL/ME1/PCCA/CS/PGP/ACSS2	-0.493076489031032
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	23/1784	133/9376	0.908864088472302	FOS/CREB3L2/KIF5B/GNAQ/ITPR2/ATF6B/CAMK2G/CLOCK/GNAI2/MAPK14/AKT2/GSK3B/PLCB1/GNG12/GNG11/CREB1/MAOA/PPP2R2D/PRKACB/GNB4/PPP2R3B/PPP3CA/GNG5	-0.513113982140714
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	7/1784	43/9376	0.855563666701429	PLPP3/ABCA1/AGPAT1/GOT2/SCARB1/DGAT1/SLC27A4	-0.46015591944142
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	12/1784	72/9376	0.87593423019432	ADAR/NFKBIA/MAP3K1/MAVS/MAPK14/IKBKB/NFKB1/OTUD5/IRF3/ATG12/CYLD/NLRX1	-0.512257511578775
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	16/1784	95/9376	0.885154590512155	JUN/FOS/CTSL/FLT1/ATP6AP1/ATP6V1B1/ATP6V0A1/TCIRG1/ATP6V0B/ATP6V1C2/ACP5/ATP6V1A/ATP6V0A2/HLA-DRA/ATP6V1E2/ATP6V1H	-0.545359672782705
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	11/1784	67/9376	0.862860584967539	GNAQ/ITPR2/EP300/KRAS/CAMK2G/CREBBP/PLCB1/PRKACB/HRAS/RPS6KA3/PPP3CA	-0.546076066159349
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1784	32/9376	0.821188340807175	GAA/GLB1/B4GALT1/GLA/G6PC3	-0.491144596994858
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/1784	38/9376	0.829832428605145	HEXA/HEXB/UXS1/NAGK/PGM3/GFPT1	-0.509502861828727
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1784	20/9376	0.788340807174888	CYB5R3/CYB5R1/NPL	-0.459316440272266
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/1784	39/9376	0.808554674025526	GLDC/MTR/AHCYL1/MAT2A/AMT/MTHFR	-0.580735473779514
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	26/1784	154/9376	0.887309999417623	EGFR/JUN/FOS/ROCK1/GNAQ/ITPR2/NFATC3/PPP1R12A/KRAS/CAMK2G/GNAI2/ROCK2/PPP1R12B/ADCY6/PRKAB2/NFATC2/ADCY7/PLCB1/RGS2/PRKACB/HRAS/PRKAA1/CDKN1A/ADCY2/PPP3CA/RCAN1	-0.683499413308528
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	27/1784	160/9376	0.886883408071749	CDH1/ITGAV/ITGA6/GLG1/ITGB1/CLDN4/CADM1/JAM3/PTPRF/ITGB8/PTPRM/CNTNAP2/NLGN4X/F11R/CDH3/OCLN/HLA-E/CLDN19/NRXN3/CLDN23/CD276/NRCAM/CLDN3/CLDN7/HLA-DRA/NLGN1/HLA-C	-0.699552050087357
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	11/1784	69/9376	0.837850133229349	JUN/FOS/FOSB/CREB3L2/ATF6B/CAMK2G/CREB1/MAOA/PRKACB/HDAC2/PPP3CA	-0.655301629808553
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	25/1784	149/9376	0.881812983417101	GABRE/MT-ND3/MT-ND6/GNAQ/ITPR2/FAAH/NDUFB9/GNAI2/ADCY6/MAPK14/ADCY7/NDUFS1/PLCB1/MT-ND1/GNG12/GNG11/MT-ND4/PRKACB/NAPEPLD/DAGLB/ADCY2/GNB4/NDUFB7/NDUFA3/GNG5	-0.704916387989483
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/1784	75/9376	0.840896860986547	MTR/ALDH18A1/ACO2/IDH1/MAT2A/GOT2/PYCR2/PC/GOT1/SDSL/CS/BCAT1	-0.670578339582614
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	16/1784	99/9376	0.84939076867328	GNAQ/ITPR2/CAMK2G/PIK3R1/ADCY6/MAPK14/PIK3CA/PIK3R3/ADCY7/PLCB1/PIK3CB/PRKCH/TRPV4/PRKACB/MAP2K3/ADCY2	-0.730247997142123
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	29/1784	173/9376	0.880997433837062	CDK6/PABPN1/TLR3/IFNGR1/DNAJC3/ADAR/EP300/DNAJB1/NFKBIA/NXF1/KPNA6/PIK3R1/HNRNPUL1/MAVS/CREBBP/PIK3CA/PIK3R3/AKT2/XPO1/PIK3CB/IKBKB/TNFRSF1A/PYCARD/NFKB1/HLA-DRA/NUP98/IRF3/EIF2AK2/NLRX1	-0.765807527011773
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	13/1784	83/9376	0.823167107893457	DNASE2/ADAR/NFKBIA/MAVS/GSDMD/POLR3A/IKBKB/POLR3E/PYCARD/NFKB1/G3BP1/IRF3/POLR3B	-0.784384658751628
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	84/1784	480/9376	0.919730941704036	HSPA5/APP/COX6A1/MT-CO2/LRP5/FUS/MT-ND3/MT-ND6/ATF6/KIF5B/ATP2A2/RB1CC1/GPX8/GNAQ/MT-CO3/ITPR2/DDIT3/XBP1/FZD6/FZD5/MT-CYB/PSMD1/ATXN2/DVL3/KRAS/CAMK2G/NDUFB9/UBE2G2/FZD3/C9orf72/FZD10/MAPK14/LRP6/ATG2B/APC/PSEN2/GSK3B/NDUFS1/SPG11/CAT/CCS/ATG2A/PRNP/PSEN1/WNT4/PLCB1/MTOR/ATG14/WIPI2/MT-ND1/DERL1/HTT/ATXN1/DCTN1/FRAT2/ERN1/MT-ND4/TNFRSF1A/PSMD3/SIGMAR1/MAP2K7/BCL2/DCTN5/TRAP1/MT-CO1/HRAS/WIPI1/NFKB1/CAPN1/UBA1/DVL1/GPR37/BDNF/ATXN1L/MAP2K3/ACTR1B/ALS2/PIK3C3/CYC1/NDUFB7/BCL2L1/NRBF2/NDUFA3/PPP3CA	-0.875137639190458
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	38/1784	226/9376	0.883685860550022	JUN/ATP2B1/FOS/ATP2B4/SLC9A1/CREB3L2/GLI3/ATP1A1/ADRB1/ROCK1/ATP2A2/PDE4B/PPP1R12A/EP300/NFKBIA/CAMK2G/GNAI2/ROCK2/PIK3R1/ADCY6/CREBBP/PDE3B/PIK3CA/PIK3R3/AKT2/PDE10A/ADCY7/RAC3/PIK3CB/CREB1/ATP1B3/PRKACB/NFKB1/PPARA/BDNF/TIAM1/VAV3/ADCY2	-0.857987870006385
Organismal Systems	Nervous system	hsa04730	Long-term depression	9/1784	60/9376	0.788340807174888	IGF1R/GNAQ/ITPR2/GNA12/KRAS/GNA11/GNAI2/PLCB1/HRAS	-0.797265523945385
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	16/1784	102/9376	0.824408687241713	ATP2B1/ATP2B4/SLC9A1/ATP1A1/ATP2A2/SLC4A2/GNAQ/ITPR2/ADCY6/ADCY7/PLCB1/SLC12A2/BST1/CLCA2/ATP1B3/ADCY2	-0.86431993398332
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1784	23/9376	0.685513745369468	MLH3/RPA1/RFC1	-0.731973035335738
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1784	23/9376	0.685513745369468	ATP1A1/ATP1B3/GLUD1	-0.731973035335738
Human Diseases	Substance dependence	hsa05032	Morphine addiction	14/1784	91/9376	0.808554674025526	GABRE/PDE4B/GNAI2/ADCY6/PDE3B/PDE7A/PDE10A/ADCY7/GNG12/GNG11/PRKACB/ADCY2/GNB4/GNG5	-0.889568658627516
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	15/1784	97/9376	0.812722481623596	FOS/RPS6KA5/GNAQ/CAMK2G/GNAI2/ADCY6/ADCY7/PLCB1/GNG12/GNG11/CREB1/PRKACB/ADCY2/GNB4/GNG5	-0.898723068106537
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/1784	103/9376	0.816404719404415	COL14A1/COL4A2/KCNN4/SLC38A2/SLC3A2/DPP4/SLC1A5/MME/COL4A1/ATP1A1/COL21A1/PRCP/COL5A2/KCNK5/COL8A1/ATP1B3	-0.908186327092162
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1784	17/9376	0.618306515431285	CSAD/GGT7	-0.763535874831304
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1784	17/9376	0.618306515431285	MTR/TXNRD2	-0.763535874831304
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1784	17/9376	0.618306515431285	CA8/GLUD1	-0.763535874831304
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	18/1784	116/9376	0.815524972939539	SLC38A2/SLC38A1/SLC1A3/GNAQ/ITPR2/HOMER1/SHANK2/GNAI2/ADCY6/ADCY7/PLCB1/GNG12/GNG11/PRKACB/ADCY2/GNB4/PPP3CA/GNG5	-0.969094318639245
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1784	38/9376	0.691527023837621	SIRT7/NT5C/BST1/NAPRT/NNT	-0.923606436075098
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1784	10/9376	0.525560538116592	SUOX	-0.727626808022308
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	24/1784	154/9376	0.819055384077806	ATP2B1/ATP2B4/SLC9A1/CREB3L2/ATP1A1/ADRB1/ATP2A2/RPS6KA5/GNAQ/ATF6B/CAMK2G/GNAI2/ADCY6/MAPK14/AKT2/ADCY7/PLCB1/CREB1/BCL2/PPP2R2D/ATP1B3/PRKACB/ADCY2/PPP2R3B	-1.09748458767421
NA	NA	hsa04081	Hormone signaling	35/1784	219/9376	0.839936933063046	ITGAV/PRLR/IGF1R/SLC40A1/ADRB1/INSR/GNAQ/GNA12/SLC16A2/SMAD5/IRS2/GHR/GNA11/GNAI2/PIK3R1/ADCY6/PIK3CA/PIK3R3/BMPR1A/IGF2/ADCY7/PLCB1/PIK3CB/GNG12/APPL1/GNG11/PRKACB/SMAD4/THRB/ADIPOR2/ADCY2/STAT3/GNB4/ACVR1/GNG5	-1.16182722195072
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/1784	33/9376	0.63704307650496	VAMP2/STX16/GOSR1/BET1L	-1.01245060473797
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	53/1784	323/9376	0.862374876785739	EGFR/MET/CDK6/SOX4/ST14/TIMP3/ERBB3/ROCK1/NOTCH3/RPS6KA5/FOXP1/DNMT3A/BMPR2/MDM4/ABCB1/DICER1/ATM/IRS2/EP300/TP63/KRAS/RDX/MCL1/EFNA5/SOCS1/EFNA1/FZD3/PIK3R1/ERBB2/CREBBP/PIK3CA/PIK3R3/PLAU/APC/NOTCH2/MTOR/SHC1/ABCC1/PIK3CB/IKBKB/PDGFA/BCL2/MDM2/HRAS/ABL1/NFKB1/BMI1/CDKN1A/HDAC2/PTEN/STAT3/PDGFB/SOS2	-1.22013443838072
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	16/1784	109/9376	0.771465010079401	JUN/FOS/TLR3/NFKBIA/PIK3R1/MAPK14/PIK3CA/PIK3R3/AKT2/TAB2/PIK3CB/IKBKB/MAP2K7/NFKB1/MAP2K3/IRF3	-1.16332572865269
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	6/1784	47/9376	0.670928346531819	ACSS1/HAGH/PC/ACACA/ME1/ACSS2	-1.09629344994199
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	28/1784	181/9376	0.813021826920695	CTSD/ATP6AP1/EEA1/IL10RB/LAMP2/LAMP1/IFNGR1/ATP6V0A1/EP300/PLA2R1/ARHGEF12/CAMK2G/TCIRG1/CREBBP/ATP6V0B/MAPK14/AKT2/KSR1/RAB5B/TNFRSF1A/CREB1/BCL2/NFKB1/ATP6V0A2/HLA-DRA/ATP6V1H/PIK3C3/PPP3CA	-1.23128700579069
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1784	27/9376	0.58395615346288	HADHA/ACADS/ACSM3	-1.04940557892426
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	20/1784	134/9376	0.784418713606854	MYH10/ADM/ROCK1/GNAQ/ITPR2/GNA12/PPP1R12A/ARHGEF12/GNA11/ROCK2/PPP1R12B/ADCY6/CALD1/ADCY7/PLCB1/PRKCH/ADORA2B/PRKACB/ADCY2/MYH9	-1.21838751388378
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	12/1784	87/9376	0.724911087057368	COX6A1/MT-CO2/SLC9A1/ASPH/ATP1A1/ATP2A2/MT-CO3/MT-CYB/ATP1B3/MT-CO1/SLC9A7/CYC1	-1.24954872445816
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/1784	42/9376	0.625667307281657	HADHA/DHTKD1/CAT/MAOA/AOC1	-1.17856480758508
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/1784	28/9376	0.563100576553491	MOCS1/CBR1/GGH	-1.12229259889426
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1784	36/9376	0.58395615346288	GAA/AGL/G6PC3/PYGB	-1.21233286558951
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/1784	89/9376	0.708620950269562	SLC38A2/GABRE/SLC38A1/GNAI2/ADCY6/ADCY7/GNG12/GNG11/PRKACB/ADCY2/GNB4/GNG5	-1.33881499120776
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/1784	37/9376	0.56817355472064	UXS1/NAGK/PGM3/GFPT1	-1.27574793220382
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1784	22/9376	0.47778230737872	MAOA/AOC1	-1.18869162446648
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/1784	78/9376	0.673795561687938	JUN/FOS/ITGB1/GNAI2/MAPK14/SERPING1/PYCARD/NFKB1/IRF3/IRF1	-1.40232074792878
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	7/1784	59/9376	0.623546401155279	NME3/ENTPD6/CANT1/ENTPD4/NT5C/NT5C3A/CAD	-1.40606168806504
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/1784	59/9376	0.623546401155279	MGST3/GPX8/MGST2/GGT7/IDH1/GCLM/GSTK1	-1.40606168806504
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/1784	66/9376	0.63704307650496	JUN/GATA3/IFNGR1/IL4R/SMAD2/NFKB1/HLA-DRA/STAT3	-1.43435673139802
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/1784	31/9376	0.508606972370895	HADHA/CSAD/ACADS	-1.3283886234146
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	41/1784	268/9376	0.804029181447025	HSPA5/SLC39A10/COX6A1/MT-CO2/DUSP1/MT-ND3/MT-ND6/SLC39A7/ATF6/KIF5B/MT-CO3/ITPR2/DDIT3/SLC39A1/XBP1/MT-CYB/PSMD1/CAMK2G/SLC11A2/NDUFB9/UBE2G2/GNAI2/SLC39A3/NDUFS1/SLC39A13/MT-ND1/ERN1/MT-ND4/PSMD3/MAOA/TRAP1/PRKACB/MT-CO1/UBA1/GPR37/SLC39A6/CYC1/NDUFB7/NFE2L2/BCL2L1/NDUFA3	-1.57780110613172
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1784	15/9376	0.350373692077728	TPK1	-1.22054297279526
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	19/1784	138/9376	0.723597842334438	IGF1R/ITPR2/SLK/SMC1A/CAMK2G/FBXW11/SMC3/ADCY6/MAPK14/CPEB4/ADCY7/ANAPC1/PRKACB/ANAPC4/CUL1/CDC23/ADCY2/RPS6KA3/PPP3CA	-1.58561211962812
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	27/1784	187/9376	0.758830723483849	JUN/PKN2/ITPR2/ANTXR2/NFKBIA/XIAP/TRPM7/MAVS/MAPK14/GSDMD/TAB3/BIRC2/PLCB1/CTSB/TAB2/IKBKB/DHX33/NAIP/BCL2/PYCARD/NFKB1/TP53BP1/IRF3/ATG12/RBCK1/BCL2L1/NLRX1	-1.61478096590647
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	8/1784	68/9376	0.618306515431285	DHRS4L2/RDH11/RETSAT/RDH10/DGAT1/DHRS3/DHRS4/ALDH1A3	-1.53124956822678
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	11/1784	88/9376	0.65695067264574	F5/CD46/CD55/SERPINE2/TFPI/PLAU/CFD/SERPINE1/SERPING1/CD59/CLU	-1.56726259383697
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	15/1784	115/9376	0.685513745369468	APP/SLC6A4/DUSP1/GNAQ/ITPR2/KRAS/GNAI2/PLCB1/GNG12/GNG11/MAOA/PRKACB/HRAS/GNB4/GNG5	-1.64485117693579
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/1784	41/9376	0.512741988406431	GLDC/MAOA/AMT/SDSL	-1.51564928627466
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	9/1784	78/9376	0.606416005519145	JUN/FOS/ITGB1/IFNGR1/NFKBIA/MAPK14/TAB2/NFKB1/HLA-DRA	-1.69197882275651
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	23/1784	168/9376	0.719517403373906	TLR3/SMPD1/IFNGR1/XIAP/TRPM7/CAMK2G/CFLAR/PARP1/BIRC2/FTL/CHMP6/TNFRSF1A/BCL2/PYCARD/GLUD1/CAPN1/AIFM1/RBCK1/EIF2AK2/STAT3/PYGB/CYLD/CHMP1A	-1.77820926370342
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	37/1784	254/9376	0.765580311429681	EGFR/ATP2B1/MET/FLT1/ATP2B4/ASPH/ADRB1/ERBB3/ATP2A2/GNAQ/MCOLN3/ITPR2/STIM2/FGFR2/NFATC3/PHKB/STIM1/CAMK2G/GNA11/ERBB2/NFATC2/ADCY7/PLCB1/TPCN1/MCOLN1/P2RX4/ORAI3/ADORA2B/PDGFA/PHKA2/PRKACB/PDGFD/PDGFC/TFEB/ADCY2/PDGFB/PPP3CA	-1.83599237202336
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/1784	44/9376	0.47778230737872	HLA-E/HLA-DRA/HLA-C/ICA1	-1.68304418717696
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/1784	37/9376	0.42613016604048	GOT2/MAOA/GOT1	-1.69538772354339
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/1784	37/9376	0.42613016604048	GNAQ/APOL1/PLCB1	-1.69538772354339
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/1784	39/9376	0.404277337012763	HLA-E/HLA-DRA/HLA-C	-1.80708137516616
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/1784	31/9376	0.33907131491393	H6PD/SHPK	-1.78669638515787
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	16/1784	133/9376	0.632253278937253	IFNGR1/KRAS/PIK3R1/HLA-E/PIK3CA/PIK3R3/NFATC2/RAC3/SHC1/PIK3CB/PTPN11/HRAS/VAV3/SOS2/PPP3CA/HLA-C	-2.0704899012981
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	11/1784	100/9376	0.578116591928251	CSF3R/ITGA6/TFRC/MME/CD55/IL4R/CSF2RA/ITGA3/IL11RA/HLA-DRA/CD59	-2.05597125885881
Human Diseases	Immune disease	hsa05310	Asthma	2/1784	32/9376	0.32847533632287	PRG2/HLA-DRA	-1.84448660564213
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	19/1784	154/9376	0.648418845728263	GUSB/NME3/RDH11/MOCS1/AK3/MAT2A/GCLM/GGCX/DHRS3/TPK1/COQ4/NAPRT/PANK3/GGH/COQ2/COASY/CAD/VKORC1L1/BCAT1	-2.13244752358842
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	15/1784	128/9376	0.615891255605381	PDE4B/NME3/ENTPD6/CANT1/ADCY6/PDE3B/ENTPD4/AK3/PDE7A/PDE10A/ADCY7/NT5C/GMPR/FHIT/ADCY2	-2.12099786798995
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/1784	51/9376	0.412204343620856	PLPP3/PLD3/CEPT1/CHPT1	-2.04029048290939
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	37/1784	275/9376	0.707117814920506	HSPA5/LAMC1/COX6A1/MT-CO2/EGR1/MT-ND3/MT-ND6/CREB3L2/KIF5B/MT-CO3/ITPR2/ATF6B/DDIT3/MT-CYB/HSPA1B/PSMD1/HSPA1A/NDUFB9/HSPA8/PIK3R1/MAPK14/PIK3CA/PIK3R3/GSK3B/NDUFS1/PRNP/MT-ND1/PIK3CB/MT-ND4/CREB1/PSMD3/PRKACB/MT-CO1/CYC1/NDUFB7/NDUFA3/PPP3CA	-2.38956973575476
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/1784	45/9376	0.350373692077728	HLA-E/HLA-DRA/HLA-C	-2.11743813234483
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	8/1784	85/9376	0.494645212345028	NME3/ENTPD6/CANT1/ENTPD4/AK3/NT5C/NT5C3A/GMPR	-2.26871311081136
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/1784	46/9376	0.342756872684734	PSMD1/PSME4/PSMD3	-2.16605315956491
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1784	26/9376	0.202138668506382	HES1	-1.97475512440622
Human Diseases	Substance dependence	hsa05034	Alcoholism	23/1784	191/9376	0.632873946423121	FOSB/CREB3L2/ATF6B/SLC29A3/KRAS/SLC29A1/GNAI2/SLC29A2/SHC1/GNG12/GNG11/HDAC7/CREB1/MAOA/ADORA2B/PRKACB/HRAS/HDAC11/BDNF/HDAC2/GNB4/SOS2/GNG5	-2.48483338094686
Cellular Processes	Cell motility	hsa04814	Motor proteins	23/1784	194/9376	0.623087235911423	DYNC1H1/MYH10/KIF5B/MYO6/MYO7A/KIFC3/MYO9A/HOOK3/MYO1C/MYO9B/DYNC1LI2/KIF21A/KIF3A/DCTN1/DYNLL2/MYO5B/KIFAP3/DCTN5/KIF13B/KIF26B/ACTR1B/DYNC1LI1/MYH9	-2.57144967479241
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/1784	67/9376	0.392209356803427	ACSS1/ADPGK/MINPP1/G6PC3/ACSS2	-2.42016435177796
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1784	50/9376	0.315336322869955	LTBR/HLA-DRA/IL15RA	-2.3529871115861
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/1784	50/9376	0.315336322869955	LRP1/MET/CD81	-2.3529871115861
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1784	31/9376	0.169535657456965	GUSB	-2.24500414690115
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/1784	70/9376	0.375400384368994	MGST3/MGST2/EPHX1/CBR1/GSTK1	-2.54257733947168
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/1784	63/9376	0.333689230550217	PTGES/PTGES2/EPHX2/CBR1	-2.57221501770386
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/1784	54/9376	0.29197807673144	HLA-E/HLA-DRA/HLA-C	-2.52926305060223
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	20/1784	183/9376	0.574383101766767	LSG1/REXO1/UTP14C/MPHOSPH10/NXF1/MDN1/TCOF1/XRN1/WDR43/XPO1/POP5/XRN2/RPP25L/HEATR1/WDR36/NOP56/NOL6/GTPBP4/TBL3/WDR75	-2.81851753266404
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/1784	46/9376	0.228504581789823	GUSB/FTL	-2.54259043381737
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/1784	35/9376	0.150160153747598	ENOSF1	-2.44162739764203
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/1784	36/9376	0.14598903836572	GUSB	-2.48854913966517
NA	NA	hsa04082	Neuroactive ligand signaling	21/1784	199/9376	0.554611623138112	GABRE/SLC6A4/ADRB1/SLC1A3/GNAQ/GNA11/GNAI2/GLRB/ADCY6/P2RY6/ADCY7/PLCB1/GNG12/GNG11/P2RX4/ADORA2B/PRKACB/TAC3/ADCY2/GNB4/GNG5	-3.07836430878806
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/1784	38/9376	0.138305404767524	DCLRE1C	-2.58002073306058
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1784	79/9376	0.332633251972527	MGST3/MGST2/EPHX1/CBR1/GSTK1	-2.88743128392712
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/1784	82/9376	0.32046374275402	MGST3/GUSB/NME3/MGST2/CES2	-2.99587155494093
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/1784	73/9376	0.287978377050187	MGST3/MGST2/MAOA/GSTK1	-2.96038411889799
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1784	41/9376	0.128185497101608	GABRE	-2.71183848729413
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/1784	66/9376	0.23889115368936	STS/HSD17B12/HSD17B1	-3.00779934577324
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	24/1784	238/9376	0.529977013226815	EGFR/JUN/FOS/RPS21/IL6ST/NRP1/ADAM17/TLR3/ADAR/NFKBIA/PIK3R1/MAVS/MAPK14/PIK3CA/PIK3R3/TAB2/PIK3CB/IKBKB/CFD/TNFRSF1A/NFKB1/IRF3/EIF2AK2/STAT3	-3.56030302339458
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1784	86/9376	0.244446761914694	ADCY6/KCNK5/PLCB1/PRKACB	-3.41201870476793
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	15/1784	195/9376	0.404277337012763	CLCN3/PIK3R1/MAPK14/PIK3CA/PIK3R3/AKT2/CLCN5/GSDMD/PLCB1/MTOR/PIK3CB/HDAC7/NFKB1/HDAC11/HDAC2	-4.0749416814078
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/1784	100/9376	0.210224215246637	IL6ST/IL10RB/LTBR/TNFRSF1A	-3.84882714828033
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	27/1784	298/9376	0.476179011045234	CSF3R/IL6ST/PRLR/IL10RB/BMP7/BMPR2/IFNGR1/IL4R/LTBR/LIFR/CSF2RA/BMP4/ACVR2B/TGFBR1/GHR/GDF15/TGFBR2/ACVR2A/BMPR1A/IL11RA/TNFRSF21/IL17RA/TNFRSF1A/IL17RC/TNFSF15/ACVR1/IL15RA	-4.45451989050186
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/1784	99/9376	0.10617384608416	CFD/HLA-DRA	-4.33382969251294
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/1784	143/9376	0.110257455548935	ACTN4/ACTN1/HLA-DRA	-5.19715802269499
Genetic Information Processing	Translation	hsa03010	Ribosome	6/1784	222/9376	0.14204338868016	RPS21/MRPL32/MRPL1/MRPS5/MRPS26/MRPL43	-6.27106528322268
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	17/1784	370/9376	0.241473760756272	GABRE/PRLR/ADRB1/ADM/NR3C1/GHR/GLRB/P2RY6/S1PR2/S1PR3/PGRMC2/P2RX4/APELA/ADORA2B/THRB/CHRNB1/TAC3	-7.21623159602715
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/1784	449/9376	0.0351154034376342	CAMK2G/RGS2/PRKACB	-10.1566559203838