category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	36/181	238/9376	7.83546125632573	RPS29/RPS27/RPL37A/RPL34/RPL23/RPS28/RPL31/RPS17/RPL37/RPLP2/RPL38/RPS21/RPL39/RPL36/RPS11/RPS20/FAU/RPS14/EGFR/RPL21/RPLP1/RPL12/RPL27A/UBA52/RPL30/RPL13A/RPS15A/PIK3R3/RPS18/RPS12/RPS23/RPL7/JUN/RPS24/RPL35A/RPL18	14.985794973891
Genetic Information Processing	Translation	hsa03010	Ribosome	35/181	222/9376	8.1668408740232	RPS29/RPS27/RPL37A/RPL34/RPL23/RPS28/RPL31/RPS17/RPL37/RPLP2/RPL38/RPS21/RPL39/RPL36/RPS11/RPS20/FAU/RPS14/RPL21/RPLP1/RPL12/RPL27A/UBA52/RPL30/RPL13A/RPS15A/RPS18/RPS12/RPS23/MRPS33/RPL7/MRPL33/RPS24/RPL35A/RPL18	15.1616984217456
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	23/181	227/9376	5.24857010733322	MT-ND6/MT-ND3/MT-ND4L/UQCRB/EGFR/COX4I1/MT-ND2/NDUFB1/SLC26A2/MT-ND5/PIK3R3/SLC25A5/UQCRQ/COX6C/SOD1/UQCR10/COX7C/MET/JUN/COX7A2/NDUFB2/NDUFB11/NDUFA3	9.09113198215745
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	17/181	138/9376	6.38129554007527	MT-ND6/MT-ND3/MT-ND4L/UQCRB/COX4I1/MT-ND2/NDUFB1/MT-ND5/UQCRQ/COX6C/ATP6V1B1/UQCR10/COX7C/COX7A2/NDUFB2/NDUFB11/NDUFA3	8.93483356836507
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	23/181	268/9376	4.44561721777851	MT-ND6/MT-ND3/MT-ND4L/UQCRB/COX4I1/MT-ND2/NDUFB1/MT-ND5/UBA52/UBB/ITPR2/SLC25A5/UQCRQ/COX6C/SOD1/UQCR10/COX7C/MAOA/SLC39A10/COX7A2/NDUFB2/NDUFB11/NDUFA3	8.02919441473571
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	20/181	205/9376	5.05376633876836	MT-ND6/MT-ND3/MT-ND4L/UQCRB/COX4I1/MT-ND2/NDUFB1/MT-ND5/MPC2/PIK3R3/SLC25A5/UQCRQ/COX6C/UQCR10/COX7C/PARP1/COX7A2/NDUFB2/NDUFB11/NDUFA3	8.23334577407411
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	20/181	275/9376	3.76735308890005	MT-ND6/MT-ND3/MT-ND4L/UQCRB/COX4I1/MT-ND2/NDUFB1/MT-ND5/ITPR2/PIK3R3/SLC25A5/UQCRQ/COX6C/SOD1/UQCR10/COX7C/COX7A2/NDUFB2/NDUFB11/NDUFA3	6.53484698989476
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	21/181	308/9376	3.5318935208438	MT-ND6/MT-ND3/MT-ND4L/UQCRB/COX4I1/MT-ND2/NDUFB1/POLR2L/MT-ND5/SLC25A5/UQCRQ/COX6C/GPX8/SOD1/UQCR10/AP2A2/COX7C/COX7A2/NDUFB2/NDUFB11/NDUFA3	6.33890289311146
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	18/181	235/9376	3.96774421065005	MT-ND6/MT-ND3/MT-ND4L/UQCRB/COX4I1/MT-ND2/NDUFB1/MT-ND5/UQCRQ/COX6C/UQCR10/COX7C/CPT1A/ADCY7/COX7A2/NDUFB2/NDUFB11/NDUFA3	6.46416750868313
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	25/181	480/9376	2.69797421731123	MT-ND6/MT-ND3/MT-ND4L/UQCRB/COX4I1/MT-ND2/NDUFB1/MT-ND5/UBA52/UBB/ITPR2/SLC25A5/UQCRQ/COX6C/C9orf72/GPX8/SOD1/UQCR10/COX7C/OPTN/COX7A2/NDUFB2/NDUFB11/NDUFA3/FUS	5.35800829815018
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	21/181	368/9376	2.95604131635839	MT-ND6/MT-ND3/MT-ND4L/UQCRB/COX4I1/MT-ND2/NDUFB1/MT-ND5/UQCRQ/COX6C/C9orf72/GPX8/SOD1/UQCR10/COX7C/OPTN/COX7A2/NDUFB2/NDUFB11/NDUFA3/FUS	5.37077307884373
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	13/181	157/9376	4.28926346905022	UQCRB/COX4I1/NDUFB1/PIK3R3/UQCRQ/COX6C/UQCR10/COX7C/JUN/COX7A2/NDUFB2/NDUFB11/NDUFA3	5.83116914631108
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	20/181	388/9376	2.67016005012246	MT-ND6/MT-ND3/MT-ND4L/UQCRB/COX4I1/MT-ND2/NDUFB1/MT-ND5/ITPR2/PIK3R3/SLC25A5/UQCRQ/COX6C/UQCR10/COX7C/SLC39A10/COX7A2/NDUFB2/NDUFB11/NDUFA3	4.71402065401781
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	11/181	149/9376	3.82424264896733	MT-ND6/MT-ND3/MT-ND4L/MT-ND2/NDUFB1/MT-ND5/ITPR2/ADCY7/NDUFB2/NDUFB11/NDUFA3	4.87544138815643
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/181	73/9376	4.96722924392644	EGFR/GADD45B/PDGFD/PIK3R3/CCND1/MET/CDH1	4.77404243579346
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/181	87/9376	4.16790499777735	UQCRB/COX4I1/UQCRQ/COX6C/UQCR10/COX7C/COX7A2	4.16482111698713
NA	NA	hsa04518	Integrin signaling	9/181	154/9376	3.0273373035804	FBN1/EGFR/ITGB8/ITGB1/PDGFD/PIK3R3/CCND1/MET/CDH1	3.55895807441861
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/181	78/9376	3.98470038249044	ITGB1/PIK3R3/WASF2/MET/CDH1/ARPC1B	3.71366163010298
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	8/181	137/9376	3.02488204218252	PMAIP1/CTSC/GADD45B/CTSL/ITPR2/PIK3R3/JUN/PARP1	3.34962807303719
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/181	59/9376	4.38992415020133	EGFR/GADD45B/PIK3R3/CCND1/CDH1	3.66460354904546
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	6/181	87/9376	3.57248999809488	PMAIP1/EGFR/GADD45B/PIK3R3/CCND1/JUN	3.38203344949447
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/181	89/9376	3.49220932398038	EGFR/GJA1/ADRB1/ITPR2/PDGFD/ADCY7	3.3142926665994
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	10/181	212/9376	2.44344834775357	EGFR/ITGB1/MAGI1/PDGFD/PIK3R3/EFNA5/ADCY7/MET/CTNND1/CDH1	2.98246734159251
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/181	93/9376	3.34200677241133	EGFR/SORBS1/WASF2/MET/CTNND1/CDH1	3.18445051476092
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/181	93/9376	3.34200677241133	EGFR/CGA/ITPR2/ADCY7/MAP3K4/JUN	3.18445051476092
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/181	71/9376	3.6479651388997	EGFR/ATP6V1B1/JAM3/MET/JUN	3.14218902715555
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/181	71/9376	3.6479651388997	IDH1/EGFR/LDHB/PIK3R3/MET	3.14218902715555
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/181	99/9376	3.13946090741671	EGFR/PDGFD/PIK3R3/WASF2/PLPP3/JUN	3.00239088716355
NA	NA	hsa04517	IgSF CAM signaling	12/181	299/9376	2.07897411260371	NRP2/ITGB1/NLGN4X/MAGI1/NRCAM/PIK3R3/SORBS1/JAM3/DYNLL2/MYLK3/CDH1/ARPC1B	2.66026260851698
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/181	73/9376	3.54802088851888	EGFR/GADD45B/PIK3R3/CCND1/MET	3.06621047112418
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/181	75/9376	3.45340699815838	CGA/ITPR2/GPX8/LRP2/ADCY7	2.99284667359851
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	6/181	105/9376	2.96006314127861	UBA52/UBB/FIS1/OPTN/JUN/TOMM7	2.83367787809886
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	9/181	203/9376	2.29660071306099	EGFR/ITGB8/ITGB1/PDGFD/PIK3R3/CCND1/MYLK3/MET/JUN	2.6202796088254
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/181	59/9376	3.51193932016106	CGA/ADRB1/PIK3R3/ADCY7	2.71547720237409
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/181	61/9376	3.39679376868037	FTL/ATP2B1/SLC40A1/ATOX1	2.63483372514247
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/181	37/9376	4.20008959235479	GADD45B/CCND1/CDH1	2.73628840756046
Organismal Systems	Immune system	hsa04611	Platelet activation	6/181	126/9376	2.46671928439884	ITGB1/ITPR2/PIK3R3/ADCY7/MYLK3/VAMP8	2.32546853250633
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	7/181	160/9376	2.26629834254144	ITGB8/ITGB1/NLGN4X/NRCAM/JAM3/NRXN3/CDH1	2.26659463029527
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	9/181	232/9376	2.00952562392837	SCIN/EGFR/ITGB8/ITGB1/PDGFD/PIK3R3/WASF2/MYLK3/ARPC1B	2.18445090928786
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/181	98/9376	2.64291351899876	SCIN/PIK3R3/WASF2/PLPP3/ARPC1B	2.29376866668022
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/181	17/9376	6.0942476438089	NRP2/DAG1	2.9494351329514
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/181	99/9376	2.61621742284726	EGFR/PIK3R3/CCND1/ADCY7/JUN	2.26810242019833
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	8/181	204/9376	2.03141588126964	EGFR/ITGB1/DDX5/CTSL/ITPR2/PIK3R3/CCND1/MET	2.08961334770069
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/181	41/9376	3.79032475407627	EGFR/CCND1/CDH1	2.51210956995448
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/181	169/9376	2.14560789826408	UBA52/CTSL/UBB/PIK3R3/C9orf72/OPTN/VAMP8	2.1084792857361
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/181	105/9376	2.46671928439884	ITGB8/ITGB1/ADRB1/ADCY7/DAG1	2.12044699073866
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/181	106/9376	2.44344834775357	EGFR/SPINT1/PDGFD/PIK3R3/CCND1	2.09683072698143
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	9/181	253/9376	1.84272705435329	EGFR/ITGB1/UBA52/UBB/ITPR2/PIK3R3/WASF2/JUN/ARPC1B	1.9064587744045
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/181	254/9376	1.83547222343063	EGFR/ATP2B1/ADRB1/ITPR2/PDGFD/SLC25A5/ADCY7/MYLK3/MET	1.89388192357304
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/181	76/9376	2.72637394591451	SLC27A2/DBI/SORBS1/CPT1A	2.12006537811924
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/181	76/9376	2.72637394591451	EGFR/GADD45B/PIK3R3/CCND1	2.12006537811924
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/181	77/9376	2.69096649207146	EGFR/GADD45B/PIK3R3/CCND1	2.09031289331062
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	7/181	184/9376	1.9706942109056	SEMA6D/ITGB1/PIK3R3/EFNA5/BMP7/MET/SEMA6A	1.8656724655699
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/181	80/9376	2.59005524861878	EGFR/PDGFD/PIK3R3/MET	2.00381770499079
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/181	150/9376	2.07204419889503	EGFR/GADD45B/PIK3R3/CCND1/MET/CDH1	1.85695189924013
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	6/181	154/9376	2.0182248690536	EGFR/ITPR2/CCND1/ADCY7/MYLK3/JUN	1.78747740343566
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/181	52/9376	2.98852528686783	HSD17B1/CGA/ADCY7	2.0173475084315
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	6/181	157/9376	1.97966006263856	GADD45B/ITPR2/PIK3R3/SLC25A5/CCND1/HIPK2	1.73673029992355
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/181	157/9376	1.97966006263856	CCND1/ID2/BMP7/CDH1/RASSF6/FRMD6	1.73673029992355
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/181	86/9376	2.40935371964538	ITGB8/ITGB1/GJA1/DAG1	1.8420882548663
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/181	89/9376	2.32813954932026	ITGB8/ITGB1/CD47/DAG1	1.76624135307481
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/181	56/9376	2.7750591949487	CCND1/LRP2/PTCH2	1.86916636190808
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/181	57/9376	2.72637394591451	HACD3/HADHA/CPT1A	1.83415782902274
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/181	28/9376	3.70007892659826	HACD3/HADHA	2.00745205667241
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	6/181	166/9376	1.87232909538707	ATP2B1/ADRB1/ITPR2/SLC25A5/ADCY7/MYLK3	1.59093943086978
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/181	93/9376	2.22800451494089	ATP2B1/ADRB1/ITPR2/ADCY7	1.66973027396756
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/181	93/9376	2.22800451494089	ITGB1/GADD45B/PIK3R3/CCND1	1.66973027396756
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/181	59/9376	2.6339544901208	IDH1/GPX8/GGCT	1.76635085570272
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/181	29/9376	3.57248999809488	RASSF6/FRMD6	1.94655030322284
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	8/181	250/9376	1.65763535911602	CTSC/ASAH1/CTSL/LGMN/GNS/ATP6V1B1/AP2A2/VAMP8	1.47864523082799
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	6/181	170/9376	1.82827429314267	ITGB1/MAGI1/CCND1/JAM3/JUN/ARPC1B	1.52901665759586
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	5/181	133/9376	1.94740996136751	EGFR/GADD45B/PIK3R3/CCND1/PLK2	1.54385443435414
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/181	62/9376	2.5065050793085	PIK3R3/SOD1/ADCY7	1.66973437094388
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/181	32/9376	3.23756906077348	LDHB/HADHA	1.77882851009698
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	5/181	138/9376	1.8768516294339	ITGB1/PIK3R3/WASF2/JUN/ARPC1B	1.45588052445677
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/181	65/9376	2.39082022949426	CGA/ITPR2/PIK3R3	1.57862353317358
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/181	139/9376	1.86334909972574	EGFR/ITPR2/PIK3R3/ADCY7/JUN	1.43872379895409
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	5/181	140/9376	1.85003946329913	ITPR2/CCND1/ADCY7/MYLK3/CDH1	1.42170733140763
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/181	226/9376	1.60445900356916	ATP2B1/CGA/ADRB1/PDE4B/PIK3R3/ADCY7/JUN	1.29050467534362
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/181	70/9376	2.22004735595896	PIK3R3/MET/JUN	1.43745164046384
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/181	36/9376	2.87783916513198	GALNT11/C1GALT1	1.58374502552075
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/181	71/9376	2.18877908333982	CGA/PIK3R3/CCND1	1.41065625695305
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/181	148/9376	1.75003733014783	EGFR/GADD45B/PIK3R3/CCND1/JUN	1.29035438746227
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	5/181	149/9376	1.73829211316697	EGFR/PDGFD/PIK3R3/ADCY7/PLPP3	1.27450094502321
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	10/181	362/9376	1.43096975061811	CSF3R/EGFR/ITGB8/ITGB1/MAGI1/PDGFD/PIK3R3/EFNA5/CCND1/MET	1.17325214189429
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/181	75/9376	2.07204419889503	PMAIP1/GADD45B/CCND1	1.30775852397175
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	6/181	196/9376	1.58574811139926	UBA52/UBB/ITPR2/PIK3R3/CCND1/JUN	1.16269726510661
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/181	76/9376	2.04478045943588	ITPR2/ADCY7/MYLK3	1.2830377132529
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	4/181	115/9376	1.80177756425655	EGFR/ITPR2/PDE4B/ADCY7	1.21373237480352
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/181	77/9376	2.0182248690536	GADD45B/PIK3R3/CCND1	1.25869352352743
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/181	116/9376	1.78624499904744	ITGB1/PIK3R3/JAM3/CTNND1	1.19544735713739
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	6/181	201/9376	1.54630164096644	DDX5/GADD45B/SPINT1/ID2/MET/FUS	1.09844054799457
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/181	42/9376	2.46671928439884	HADHA/MAOA	1.33655491679331
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/181	42/9376	2.46671928439884	FTL/SLC40A1	1.33655491679331
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/181	43/9376	2.40935371964538	HADHA/CPT1A	1.29954900110465
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/181	44/9376	2.35459568056253	TUSC3/TMEM258	1.26356538042617
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/181	12/9376	4.31675874769797	CD46	1.61295727093872
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/181	82/9376	1.89516237703813	CD74/CTSL/LGMN	1.14223765186054
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/181	83/9376	1.87232909538707	SLC27A2/IDH1/SOD1	1.11992900997551
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	5/181	168/9376	1.54169955274928	CSF3R/EGFR/PIK3R3/CCND1/LIFR	0.993984292337606
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/181	86/9376	1.80701528973404	EGFR/PIK3R3/JUN	1.0548050258743
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	5/181	170/9376	1.52356191095223	EGFR/GADD45B/PIK3R3/CCND1/MET	0.966509391582408
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/181	14/9376	3.70007892659826	B3GNT2	1.41842121274087
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/181	217/9376	1.43228861674772	EGFR/ADRB1/PIK3R3/CCND1/ADCY7/JUN	0.903917294745598
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	4/181	130/9376	1.59388015299618	EGFR/PIK3R3/ADCY7/JUN	0.956626929256046
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/181	49/9376	2.11433081519901	GALNT11/C1GALT1	1.09721124761209
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/181	49/9376	2.11433081519901	MAOA/JUN	1.09721124761209
NA	NA	hsa04081	Hormone signaling	6/181	219/9376	1.41920835540755	SLC40A1/CGA/ADRB1/PIK3R3/ADCY7/SLC16A2	0.880692786812076
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/181	90/9376	1.72670349907919	EGFR/PIK3R3/JUN	0.971881298428684
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/181	178/9376	1.45508721832516	TLE4/LGR5/SERPINF1/CCND1/JUN	0.860016919453248
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/181	52/9376	1.99235019124522	LRPAP1/LRP2	1.00673358242948
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/181	136/9376	1.52356191095223	CD46/PIK3R3/CCND1/JUN	0.862880335083396
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/181	16/9376	3.23756906077348	MAOA	1.25674618095274
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/181	53/9376	1.95475867820286	ATP2B1/AP2A2	0.977918734210365
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	3/181	95/9376	1.63582436754871	CTSL/ATP6V1B1/JUN	0.873877672098589
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/181	55/9376	1.88367654445002	ASAH1/PLPP3	0.922130691973106
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/181	98/9376	1.58574811139926	ATP2B1/ITPR2/ADCY7	0.817797558397073
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/181	56/9376	1.85003946329913	TUSC3/TMEM258	0.895105456547357
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	6/181	233/9376	1.33393403362341	FBN1/ITGB8/ITGB1/FBLN1/FBN2/DAG1	0.724174691282248
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/181	99/9376	1.56973045370835	ITPR2/PIK3R3/ADCY7	0.799525486267905
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/181	99/9376	1.56973045370835	ITGB8/ITGB1/DAG1	0.799525486267905
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/181	101/9376	1.53864668234779	PIK3R3/CCND1/JUN	0.763583922943183
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/181	19/9376	2.72637394591451	GNS	1.05679905848747
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/181	102/9376	1.52356191095223	ATP2B1/ITPR2/ADCY7	0.745905214288411
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/181	20/9376	2.59005524861878	DHCR24	0.998691066047727
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/181	20/9376	2.59005524861878	NPL	0.998691066047727
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/181	105/9376	1.48003157063931	ITPR2/PIK3R3/JUN	0.693985216018251
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/181	107/9376	1.45236742913203	LDHB/ITPR2/CPT1A	0.660261287446292
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/181	63/9376	1.64447952293256	GADD45B/PTCH2	0.720084819059906
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/181	22/9376	2.35459568056253	MAOA	0.892424332125081
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	4/181	155/9376	1.33680270896453	ITGB1/CTSL/COLEC12/ATP6V1B1	0.593200451448491
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/181	155/9376	1.33680270896453	EGFR/ITPR2/CCND1/ADCY7	0.593200451448491
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/181	109/9376	1.42571848547823	SLC27A2/PIK3R3/CPT1A	0.627213265063291
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/181	110/9376	1.41275740833752	EGFR/LDHB/PIK3R3	0.610933767912968
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/181	110/9376	1.41275740833752	FBN1/ID2/BMP7	0.610933767912968
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/181	110/9376	1.41275740833752	CPEB4/PIK3R3/ADCY7	0.610933767912968
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/181	65/9376	1.59388015299618	ITPR2/ADCY7	0.67407215218993
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	7/181	300/9376	1.20869244935543	EGFR/GADD45B/PDGFD/EFNA5/MAP3K4/MET/JUN	0.515429390339331
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/181	23/9376	2.25222195532068	PCYOX1	0.8435655271852
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	5/181	205/9376	1.26344158469209	PMAIP1/SCIN/PIK3R3/CCND1/JUN	0.535059368690452
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/181	24/9376	2.15837937384899	EXTL2	0.7971742217917
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/181	68/9376	1.52356191095223	PIK3R3/CCND1	0.607915717453044
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/181	115/9376	1.35133317319241	ITPR2/PIK3R3/ADCY7	0.531848814005519
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/181	69/9376	1.50148130354712	ADRB1/ITPR2	0.586574924465253
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/181	69/9376	1.50148130354712	MAOA/JUN	0.586574924465253
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/181	70/9376	1.48003157063931	CCND1/DAG1	0.565569988180946
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/181	26/9376	1.99235019124522	SLC52A3	0.71087769076165
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/181	27/9376	1.91855944342132	HADHA	0.67058776813372
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/181	27/9376	1.91855944342132	HACD3	0.67058776813372
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/181	120/9376	1.29502762430939	MAGED1/PIK3R3/JUN	0.456342262289395
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/181	122/9376	1.27379766325514	PIK3R3/CCND1/CPT1A	0.427064983780355
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/181	122/9376	1.27379766325514	PIK3R3/CCND1/SLC16A2	0.427064983780355
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/181	122/9376	1.27379766325514	ITPR2/PIK3R3/ADCY7	0.427064983780355
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/181	28/9376	1.85003946329913	B3GNT2	0.63198651418772
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/181	28/9376	1.85003946329913	MOCS2	0.63198651418772
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/181	28/9376	1.85003946329913	ATP6V1B1	0.63198651418772
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/181	75/9376	1.38136279926335	PMAIP1/PIK3R3	0.46521444915837
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/181	125/9376	1.24322651933702	ORMDL1/ASAH1/PIK3R3	0.384079077459992
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	5/181	224/9376	1.15627466456196	PIK3R3/SLC25A5/CCND1/ADCY7/JUN	0.332126583219169
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/181	30/9376	1.72670349907919	IDH1	0.559311886673652
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/181	78/9376	1.32823346083015	BTG3/BTG2	0.408398784799877
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/181	78/9376	1.32823346083015	ITGB1/JUN	0.408398784799877
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/181	78/9376	1.32823346083015	ITGB1/JUN	0.408398784799877
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	5/181	227/9376	1.14099350159418	EGFR/ITPR2/PIK3R3/CCND1/ADCY7	0.301699277459674
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/181	79/9376	1.31142037904749	ATP6V1B1/AP2A2	0.38997630314445
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/181	31/9376	1.67100338620567	HADHA	0.525006843789356
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/181	31/9376	1.67100338620567	PGP	0.525006843789356
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	7/181	333/9376	1.08891211653643	EGFR/ITGB8/ITGB1/MAGI1/PIK3R3/ATP6V1B1/CCND1	0.231779946801272
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/181	32/9376	1.61878453038674	PMAIP1	0.491922946002129
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/181	33/9376	1.56973045370835	IDH1	0.459972945958786
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/181	33/9376	1.56973045370835	VAMP8	0.459972945958786
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/181	134/9376	1.15972623072483	ITPR2/ADCY7/MYLK3	0.261273112568009
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/181	34/9376	1.52356191095223	POLR2L	0.4290783778309
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/181	34/9376	1.52356191095223	BHLHE41	0.4290783778309
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	5/181	238/9376	1.08825850782302	EGFR/PDGFD/PIK3R3/EFNA5/MET	0.193494462676285
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/181	86/9376	1.20467685982269	ADCY7/PCLO	0.267521796882305
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/181	138/9376	1.12611097766034	ITPR2/CPEB4/ADCY7	0.209388350472049
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/181	36/9376	1.43891958256599	AGL	0.370179043232212
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/181	88/9376	1.17729784028127	F5/CD46	0.23444055288666
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/181	37/9376	1.40002986411826	MAOA	0.342052010818649
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/181	142/9376	1.09438954166991	ITPR2/PIK3R3/JUN	0.159009170939113
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	3/181	142/9376	1.09438954166991	CTSL/PIK3R3/JUN	0.159009170939113
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/181	90/9376	1.15113566605279	PIK3R3/ADCY7	0.202126352148287
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/181	38/9376	1.36318697295725	PIK3R3	0.31473437946528
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/181	91/9376	1.1384858235687	PIK3R3/JUN	0.186244784164546
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/181	91/9376	1.1384858235687	PDE4B/ADCY7	0.186244784164546
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/181	144/9376	1.07918968692449	PIK3R3/ID2/LIFR	0.134354133694324
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/181	144/9376	1.07918968692449	ITPR2/PIK3R3/SLC25A5	0.134354133694324
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	5/181	250/9376	1.03602209944751	EGFR/DAB2/AP2A2/RAB31/ARPC1B	0.0809930682925471
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	4/181	200/9376	1.03602209944751	ITGB1/WASF2/JUN/ARPC1B	0.0722447637311851
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/181	41/9376	1.26344158469209	MAOA	0.237174588750713
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	4/181	205/9376	1.01075326775367	GADD45B/PIK3R3/CCND1/JUN	0.0218402749982087
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/181	98/9376	1.0571654075995	ITPR2/PIK3R3	0.0798120042554988
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/181	43/9376	1.20467685982269	PLPP3	0.188730199540497
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/181	154/9376	1.0091124345268	ATP2B1/ADRB1/ADCY7	0.0159967324527045
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/181	44/9376	1.17729784028127	PARP1	0.165383232959006
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/181	44/9376	1.17729784028127	DYNLL2	0.165383232959006
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	3/181	156/9376	0.99617509562261	EGFR/PIK3R3/CCND1	-0.00675875151233372
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	3/181	158/9376	0.983565284285614	TFDP2/GADD45B/CCND1	-0.0292295040493434
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/181	46/9376	1.12611097766034	FTL	0.12029291396788
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/181	103/9376	1.00584669849273	PIK3R3/JUN	0.0083708245564404
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	6/181	323/9376	0.962249627969827	EGFR/SOX4/PIK3R3/EFNA5/CCND1/MET	-0.0968668764499619
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/181	47/9376	1.10215116962501	LDHB	0.098497177326059
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/181	47/9376	1.10215116962501	PIK3R3	0.098497177326059
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/181	105/9376	0.986687713759537	GADD45B/PARP1	-0.0192456713419509
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/181	48/9376	1.07918968692449	HADHA	0.0771692065393664
NA	NA	hsa03272	Virion - Hepatitis viruses	1/181	48/9376	1.07918968692449	EGFR	0.0771692065393664
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/181	48/9376	1.07918968692449	PIK3R3	0.0771692065393664
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/181	50/9376	1.03602209944751	MAOA	0.0358307068934944
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/181	50/9376	1.03602209944751	MET	0.0358307068934944
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/181	109/9376	0.95047899031882	PIK3R3/JUN	-0.0729595618486527
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/181	51/9376	1.01570794063482	PLPP3	0.0157807986244529
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/181	51/9376	1.01570794063482	ATP6V1B1	0.0157807986244529
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	3/181	168/9376	0.925019731649566	FTL/SLC25A5/PARP1	-0.137584032693646
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/181	54/9376	0.959279721710661	LDHB	-0.0421019418271624
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/181	54/9376	0.959279721710661	CGA	-0.0421019418271624
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/181	115/9376	0.900888782128273	ITPR2/MAOA	-0.150034746792477
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/181	174/9376	0.893122499523719	TUSC3/TMEM258/SIL1	-0.199649789674
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/181	116/9376	0.893122499523719	IDH1/PGP	-0.162502051697135
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/181	116/9376	0.893122499523719	ITPR2/ADCY7	-0.162502051697135
NA	NA	hsa04519	Cadherin signaling	7/181	404/9376	0.897543898036212	EGFR/GJA1/TMC5/MET/CTNND1/CDH1/ARPC1B	-0.295347254220436
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/181	119/9376	0.870606806258415	PIK3R3/JUN	-0.199296118356034
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/181	122/9376	0.849198442170093	PIK3R3/JUN	-0.235217730067579
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/181	60/9376	0.863351749539595	PIK3R3	-0.148975214632971
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/181	60/9376	0.863351749539595	ITPR2	-0.148975214632971
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/181	62/9376	0.835501693102834	TLE4	-0.182321640172862
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	3/181	187/9376	0.831033769610305	ANTXR2/ITPR2/JUN	-0.327442955422191
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/181	63/9376	0.822239761466281	HADHA	-0.198613679171919
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/181	63/9376	0.822239761466281	POLR2L	-0.198613679171919
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/181	128/9376	0.80939226519337	PDE4B/ADCY7	-0.304628585105502
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/181	65/9376	0.796940076498088	PLPP3	-0.230479228793723
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/181	66/9376	0.784865226854177	HSD17B1	-0.246068940348434
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/181	66/9376	0.784865226854177	JUN	-0.246068940348434
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/181	67/9376	0.773150820483219	LDHB	-0.261440074052506
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/181	67/9376	0.773150820483219	ITPR2	-0.261440074052506
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/181	133/9376	0.778963984547003	ITPR2/MAOA	-0.36018982966626
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/181	69/9376	0.750740651773561	PIK3R3	-0.291554804384534
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/181	70/9376	0.740015785319653	CPT1A	-0.306311664101946
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/181	138/9376	0.750740651773561	PIK3R3/SORBS1	-0.41385773652031
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/181	73/9376	0.709604177703776	MAOA	-0.349453458214379
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/181	142/9376	0.729593027779939	UBA52/UBB	-0.455529158296305
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/181	75/9376	0.690681399631676	IDH1	-0.377329625655012
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	2/181	144/9376	0.719459791282996	CCND1/CPT1A	-0.475967744948108
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/181	78/9376	0.664116730415073	ISYNA1	-0.417916926525899
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	3/181	214/9376	0.726183714566014	ITPR2/PIK3R3/JUN	-0.568486395970015
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/181	83/9376	0.624109698462358	POLR2L	-0.482582153325579
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	2/181	157/9376	0.659886687546187	CPT1A/CD47	-0.602949040869324
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/181	158/9376	0.655710189523743	PIK3R3/ATP6V1B1	-0.612327014616668
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/181	89/9376	0.582034887330064	ADCY7	-0.55583561721209
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/181	163/9376	0.63559638002915	PIK3R3/JUN	-0.658453344684594
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/181	90/9376	0.575567833026397	ADCY7	-0.56762859413211
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/181	93/9376	0.557001128735223	JUN	-0.60235008722249
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	1/181	94/9376	0.551075584812507	JUN	-0.613713150261566
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/181	97/9376	0.534032010024492	ADCY7	-0.647202851628024
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	2/181	173/9376	0.598856704882956	PIK3R3/SLC25A5	-0.747148513980537
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/181	243/9376	0.639519814473774	DDX5/CTNNBL1/FUS	-0.79877941571962
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/181	100/9376	0.518011049723757	CSF3R	-0.679838524084313
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/181	101/9376	0.512882227449264	ADCY7	-0.690536694811521
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	3/181	248/9376	0.626626269827125	DYNLL2/JUN/ARPC1B	-0.836047287459629
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	2/181	180/9376	0.575567833026397	CD74/PIK3R3	-0.806666684753401
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/181	103/9376	0.502923349246366	FUS	-0.711673680408562
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/181	103/9376	0.502923349246366	COL14A1	-0.711673680408562
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/181	103/9376	0.502923349246366	PIK3R3	-0.711673680408562
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/181	104/9376	0.498087547811305	PLPP3	-0.722116032667428
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/181	109/9376	0.47523949515941	JUN	-0.773132388760596
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	1/181	112/9376	0.462509865824783	ITGB1	-0.802840539342782
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	2/181	193/9376	0.536799015257779	PIK3R3/ADCY7	-0.912231144054305
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/181	195/9376	0.531293384332058	PIK3R3/SLC25A5	-0.927945466491211
NA	NA	hsa04082	Neuroactive ligand signaling	2/181	199/9376	0.520614120325384	ADRB1/ADCY7	-0.958982029473665
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	2/181	216/9376	0.47963986085533	PIK3R3/JUN	-1.08550597608121
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/181	133/9376	0.389481992273501	PIK3R3	-0.994871251006394
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	3/181	298/9376	0.521487633950091	CSF3R/BMP7/LIFR	-1.17775584238578
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/181	154/9376	0.336370811508933	MOCS2	-1.16499038153593
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	1/181	181/9376	0.286193950123623	CD74	-1.36048169872319
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3/181	370/9376	0.420008959235479	CGA/ADRB1/NR3C1	-1.59700117087262
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/181	191/9376	0.27120997367736	MAOA	-1.42767246238953
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/181	194/9376	0.267016005012246	DYNLL2	-1.44735735144536
NA	NA	hsa04382	Cornified envelope formation	1/181	217/9376	0.238714769457953	DST	-1.59185058190636