category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	76/1390	158/9376	3.24458610326928	ORC6/MCM6/CDC6/MCM7/MAD2L1/CDK1/MCM3/WEE1/CDT1/PKMYT1/MCM4/TFDP2/CCND1/CHEK1/CCNE1/CCNE2/CDCA5/MCM2/PCNA/NDC80/CCNA2/CDC45/ESCO2/SKP2/CDKN1C/MCM5/CDKN2A/TTK/E2F1/CCNB2/FBXO5/BUB1B/AURKB/PRKDC/CDK6/CDC25A/CCNB1/CDK2/RBL1/ORC1/CDC7/DDX11/CDC20/TRIP13/CDK7/SMC3/DBF4/BUB1/CDK4/EP300/TICRR/PLK1/E2F2/RBL2/RB1/CDC25C/TFDP1/NIPBL/CREBBP/PPP2R5C/E2F5/E2F4/STAG2/CDC14B/PPP2R5E/PTTG1/HDAC2/CHEK2/ANAPC11/YWHAE/STAG1/YWHAG/GADD45A/CDC23/ESPL1/ANAPC4	11.8706594718255
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	28/1390	36/9376	5.24636290967226	MCM6/MCM7/FEN1/MCM3/MCM4/RFC3/MCM2/PCNA/RFC4/LIG1/MCM5/POLE2/RNASEH2A/RPA3/PRIM1/DNA2/RFC2/POLA1/POLE/POLD2/RFC5/POLA2/RFC1/PRIM2/RPA1/POLD1/POLD3/RPA2	10.6493550205382
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	17/1390	23/9376	4.9856740694401	RFC3/PCNA/RFC4/LIG1/MSH2/EXO1/RPA3/RFC2/MSH6/POLD2/RFC5/RFC1/RPA1/MLH3/POLD1/POLD3/RPA2	7.98396487067445
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	22/1390	44/9376	3.3726618705036	FEN1/UNG/RFC3/PCNA/RFC4/LIG1/PARP1/POLE2/RFC2/PARP2/HMGB1/POLE/POLD2/RFC5/RFC1/POLD1/MUTYH/PNKP/NEIL1/POLD3/NEIL3/LIG3	6.58117152007006
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	21/1390	41/9376	3.45492191612564	RAD51/BRCA1/XRCC2/RAD51C/BLM/BRCA2/RPA3/POLD2/EME1/RAD54L/BRIP1/BARD1/TOPBP1/RAD54B/RPA1/POLD1/RAD50/XRCC3/RAD51D/POLD3/RPA2	6.57204964863209
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	85/1390	333/9376	1.72177933329012	EGFR/LAMB1/ITGB4/LAMA5/COL4A2/LAMC1/ITGA6/COL4A1/PARD3/ATP6V1C2/CCND1/ITGB5/CCNE1/CCNE2/ATP6V1B1/PARD6B/CCNA2/ITGB1/ITGB8/E2F1/FZD6/GNAS/PTK2/NOTCH3/CDK6/DLG3/FZD3/PPP2R2B/HRAS/CDK2/WNT4/PRKCZ/NOTCH2/TUBG1/RBL1/DLG1/FN1/CREB5/PPP2R3B/MAGI1/FZD10/ITGAV/ITGA3/FZD5/TLR3/AXIN2/CDK4/LAMB4/PARD6G/LAMC2/CRB3/EP300/DLG2/DVL3/PRKCI/RBL2/RB1/ATP6V0A4/MAPK1/PSEN1/TCF7/CREBBP/LAMB2/LAMA1/ITGB6/PPP2R5C/ATP6V0A1/SOS2/ATP6V1C1/BAD/JAG1/FZD2/COL1A1/PIK3R3/WNT3/HES6/PPP2R5E/COL1A2/ATP6V0E2/COL6A1/HDAC2/FZD8/AKT3/PPP2R3A/IKBKG	5.59498181717233
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	54/1390	184/9376	1.97960588051298	MET/BMP7/SEMA6A/SEMA6D/EPHB4/NRP1/PARD3/RASA1/PLXNB1/PARD6B/EFNA1/ITGB1/SEMA3F/PAK6/PTK2/GNAI1/RAC3/FZD3/EFNA5/CAMK2G/HRAS/ENAH/EPHA2/PLXNC1/WNT4/PRKCZ/NTN4/SEMA4C/PLXNA1/PLXNA2/PARD6G/SRGAP1/SEMA7A/RHOD/SEMA3E/MAPK1/ARHGEF12/PTCH1/EPHB3/PLXNB2/SEMA4G/NCK2/NEO1/LIMK2/SEMA3A/RGMA/PIK3R3/PAK4/EFNB2/NFATC2/SSH2/LRRC4/PPP3R1/SRGAP2	5.59865456576613
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	48/1390	157/9376	2.06226458323787	CDK1/MYBL2/CCND1/CHEK1/CCNE1/CCNE2/SLC25A4/CCNA2/CDKN2A/E2F1/CCNB2/FOXM1/CDK6/HRAS/CDC25A/RRAS2/CCNB1/CDK2/RBL1/SLC25A5/LIN9/CDK4/TGFBR2/E2F2/TRPV4/RBL2/RAD1/RB1/MAPK1/RAD9A/SERPINE1/HIPK3/E2F5/MAPK13/FOXO3/E2F4/HIPK1/CALM2/RAD50/PIK3R3/RBBP4/CHEK2/NFATC2/BTRC/GADD45A/PPP3R1/AKT3/SIRT1	5.5997547407877
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	33/1390	93/9376	2.39350197261546	LAMB1/LAMA5/COL4A2/LAMC1/ITGA6/COL4A1/CCND1/CCNE1/CCNE2/SKP2/ITGB1/TRAF4/E2F1/PTK2/CKS1B/CDK6/CDK2/CKS2/FN1/ITGAV/ITGA3/CDK4/LAMB4/LAMC2/E2F2/RB1/LAMB2/LAMA1/FHIT/PIK3R3/GADD45A/AKT3/IKBKG	5.63421314171555
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	36/1390	106/9376	2.29086466675716	EGFR/SPINT1/FOLR1/CCND1/CCNE1/CCNE2/HSP90B1/SLC19A1/IGF1R/E2F1/FGFR2/HRAS/ETV5/GSTP1/CDK2/HSP90AA1/PDGFA/CREB5/ERBB2/IGF1/EP300/PDGFD/SLC46A1/HSP90AB1/E2F2/RB1/MAPK1/TCF7/CREBBP/SOS2/BAD/FOLR3/PIK3R3/AKT3/FOLR2/IKBKG	5.57599228911783
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	57/1390	204/9376	1.8847228099873	EGFR/MET/TIMP3/CTSL/ANK3/CCND1/ITGB5/GPC1/ERBB3/ITGB1/IGF1R/FZD6/GPC3/PTK2/FZD3/CAMK2G/IGF2/SLC9A1/HRAS/RRAS2/GAB1/WNT4/PRKCB/FN1/FZD10/CTTN/ITGAV/FZD5/VAV3/SDC4/ERBB2/ARHGEF1/IGF1/CAV2/HSPG2/SDC1/MAPK1/RDX/ARHGEF12/TWIST1/TIAM1/PTCH1/MAPK13/SOS2/EIF4B/FZD2/COL1A1/PIK3R3/WNT3/PLCE1/IQGAP1/COL1A2/PPP1R12B/CAV1/FZD8/FGF2/AKT3	5.32989520969766
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	87/1390	362/9376	1.6211137167614	EGFR/MET/LAMB1/ITGB4/LAMA5/COL4A2/LAMC1/ITGA6/COL4A1/FLT1/CCND1/ITGB5/CCNE1/CCNE2/GNG12/BRCA1/HSP90B1/EFNA1/ERBB3/ITGB1/IGF1R/ITGB8/PTK2/PRLR/CDK6/EFNA5/FGFR2/PPP2R2B/IGF2/HRAS/EPHA2/PHLPP1/CDK2/HSP90AA1/PDGFA/FN1/CREB5/PPP2R3B/MAGI1/LPAR6/ITGAV/ITGA3/PRKAA2/CSH2/CDK4/LAMB4/LAMC2/GHR/ERBB2/PIK3R5/IGF1/PDGFD/IRS1/HSP90AB1/RBL2/GNG2/ANGPT1/MAPK1/BDNF/CSF3R/LAMB2/JAK3/LAMA1/ITGB6/PPP2R5C/NTF4/SOS2/BAD/FGF1/FOXO3/EIF4B/INSR/CSF1R/COL1A1/PIK3R3/PPP2R5E/COL1A2/COL6A1/THEM4/YWHAE/FGF2/YWHAG/PCK2/GNG7/AKT3/PPP2R3A/IKBKG	5.02799704954654
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	46/1390	157/9376	1.97633689226962	CDH1/BMP7/FRMD6/DLG5/RASSF6/TEAD1/AMOT/BIRC5/PARD3/CCND1/YAP1/PARD6B/ID1/FZD6/DLG3/FZD3/PPP2R2B/WWC1/BMPR1A/TEAD4/TEAD3/WWTR1/WNT4/PRKCZ/BMP4/DLG1/WTIP/FZD10/FZD5/AXIN2/TGFBR2/PARD6G/DLG2/DVL3/PRKCI/TCF7/SERPINE1/FGF1/FZD2/AJUBA/WNT3/CSNK1E/FZD8/YWHAE/BTRC/YWHAG	5.14678473457916
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	22/1390	54/9376	2.74809485744738	RAD51/UBE2T/RMI2/FANCI/BRCA1/RAD51C/FANCD2/BLM/BRCA2/RPA3/FANCB/EME1/FANCE/FANCA/BRIP1/FANCL/FANCG/RPA1/USP1/RPA2/FANCM/REV3L	5.37447084390098
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	27/1390	75/9376	2.42831654676259	PERP/CDK1/RRM2/CCND1/CHEK1/CCNE1/CCNE2/GTSE1/CDKN2A/CCNB2/PPP1R13L/CDK6/CCNB1/CDK2/SIAH1/EI24/CDK4/PIDD1/IGF1/STEAP3/SESN1/SERPINE1/PMAIP1/SIVA1/CHEK2/SESN2/GADD45A	5.18106048458352
Genetic Information Processing	Translation	hsa03010	Ribosome	58/1390	222/9376	1.76229178819107	RPS29/RPS27/RPL37A/RPS28/RPL39/RPL36/RPL37/RPS21/RPS17/RPLP0/RPSA/RPL34/RPLP2/RPL21/RPS15A/RPS12/RPL35/RPS5/MRPS26/RPS27A/RPS4Y1/RPS19/RPLP1/RPS23/MRPL1/RPS18/RPS8/MRPL37/MRPL12/RPL31/RPS15/RPL18/MRPL4/RPL12/RPS7/MRPL15/RPL22/RPL32/RPS14/MRPL19/MRPS33/MRPL46/RPL23/MRPS2/MRPS34/RPS16/RPL5/MRPS27/RPL38/RPL27A/MRPL27/MRPL17/RPL13A/MRPS15/RPL23A/RPS3/MRPL48/MRPS21	4.79535385627901
NA	NA	hsa04518	Integrin signaling	44/1390	154/9376	1.92723535457348	FBN1/CDH1/EGFR/MET/LAMB1/ITGB4/LAMA5/COL4A2/LAMC1/ITGA6/FRAS1/COL4A1/FERMT1/FLT1/CCND1/ITGB5/FERMT2/ITGB1/IGF1R/ITGB8/PTK2/RAC3/FREM2/PARVA/PDGFA/FN1/ITGAV/ITGA3/LAMB4/NPNT/LAMC2/ERBB2/IGF1/PDGFD/LAMB2/LAMA1/ITGB6/NCK2/COL1A1/PIK3R3/COL1A2/FLNB/COL6A1/AKT3	4.84023189747336
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	29/1390	89/9376	2.19791447740684	LAMB1/ITGB4/LAMA5/COL4A2/LAMC1/ITGA6/DAG1/FRAS1/COL4A1/ITGB5/HMMR/ITGB1/ITGB8/FREM2/FN1/ITGAV/ITGA3/LAMB4/NPNT/LAMC2/SDC4/HSPG2/SDC1/LAMB2/LAMA1/ITGB6/COL1A1/COL1A2/COL6A1	4.73708829397549
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	46/1390	170/9376	1.82520524756665	MYH10/CLDN4/MARVELD3/JAM3/AMOT/PARD3/CCND1/TJP1/CLDN7/PCNA/PARD6B/ITGB1/MARVELD2/AMOTL1/MPDZ/AMOTL2/DLG3/PPP2R2B/TUBA1B/OCLN/PRKCZ/ARPC5L/DLG1/NEDD4/MAGI1/CTTN/CLDN3/PRKAA2/EPB41L4B/MAP3K1/CDK4/RUNX1/PARD6G/ERBB2/CRB3/CLDN19/TUBA1C/DLG2/PRKCI/RDX/TIAM1/ACTR3C/CGN/PRKAB2/TJP2/SYNPO	4.52980327928959
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	14/1390	30/9376	3.14781774580336	TYMS/GGH/FOLR1/DHFR/SLC19A1/ATIC/SHMT1/MTR/SLC46A1/FOLR3/ABCG2/GART/FOLR2/IKBKG	4.91556621601827
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	52/1390	203/9376	1.72786617996243	EGFR/MET/LAMB1/ITGB4/LAMA5/COL4A2/LAMC1/ITGA6/COL4A1/FLT1/CCND1/ITGB5/EMP2/ITGB1/IGF1R/ITGB8/BCAR1/PAK6/PTK2/RAC3/DOCK1/PARVA/HRAS/PRKCB/PDGFA/FN1/ITGAV/ITGA3/LAMB4/PIP5K1B/LAMC2/VAV3/ERBB2/IGF1/CAV2/PDGFD/ARHGAP5/MAPK1/LAMB2/LAMA1/ITGB6/SOS2/BAD/COL1A1/PIK3R3/COL1A2/FLNB/PAK4/PPP1R12B/COL6A1/CAV1/AKT3	4.37393422763508
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	57/1390	232/9376	1.65725626395435	EGFR/ITGB4/MYH10/ITGA6/DIAPH3/ITGB5/SCIN/GNG12/ITGB1/ITGB8/BCAR1/PFN2/PAK6/PTK2/NCKAP1/RAC3/FGFR2/SLC9A1/DOCK1/HRAS/RRAS2/ENAH/PDGFA/ARPC5L/BAIAP2/FN1/ITGAV/ITGA3/PIP5K1B/VAV3/WASF1/ARHGEF1/PDGFD/ABI2/GNA12/MAPK1/RDX/ARHGEF12/CYFIP2/TIAM1/ACTR3C/ITGB6/SOS2/FGF1/LIMK2/IQGAP3/PIK3R3/IQGAP1/PAK4/PPP1R12B/WASF2/GSN/SSH2/FGF2/WASL/AKT3/CHRM3	4.2290128325333
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	22/1390	63/9376	2.35550987781204	RFC3/POLR2L/PCNA/RFC4/LIG1/POLE2/DDB1/RPA3/RFC2/POLE/POLD2/CDK7/RFC5/POLR2I/RFC1/RPA1/MNAT1/POLR2H/POLD1/POLR2D/POLD3/RPA2	4.50356614115003
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	28/1390	93/9376	2.03085015858281	CDH1/EGFR/MET/PTPRF/LMO7/PARD3/TJP1/IGF1R/YES1/SORBS1/PTPRM/RAC3/ARHGAP29/BAIAP2/TGFBR2/ERBB2/WASF1/EP300/MAPK1/TCF7/PTPRJ/CREBBP/SSX2IP/CTNND1/INSR/IQGAP1/WASF2/WASL	4.16793777458799
NA	NA	hsa04519	Cadherin signaling	87/1390	404/9376	1.45258209274165	CDH1/EGFR/MET/DSC3/DSG2/GJA1/DSP/FAT1/KRT7/LRP5/TEAD1/GABRE/TMC5/TJP1/YAP1/KRT18/KRT8/PCDH11X/IGF1R/AMOTL1/MYO7A/CDH3/LIMA1/FZD6/PTK2/MPDZ/NCKAP1/AMOTL2/RAC3/FZD3/PKP3/WWC1/HRAS/DSC2/MYO1D/TEAD4/RRAS2/TEAD3/PKP2/CIB2/ENAH/WWTR1/MYO1C/GABRA4/KRT23/KRT80/WNT4/ARPC5L/WTIP/FZD10/TMC1/FZD5/AXIN2/VAV3/ERBB2/WASF1/LRP6/EP300/ABI2/PCDH11Y/DVL3/ATN1/PCDHGC3/MAPK1/PSEN1/TCF7/TMC4/CREBBP/TMC6/CYFIP2/ACTR3C/ADAM10/CTNND1/CDH4/MAPK13/DAAM1/KRT19/FZD2/RERE/AJUBA/WNT3/JUP/FZD8/YWHAE/TMC8/YWHAG/IKBKG	3.87946467578259
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	37/1390	138/9376	1.80852882911062	MAD2L1/CDK1/PKMYT1/CCNE1/CCNE2/IGF1R/CCNB2/FBXO5/CAMK2G/CCNB1/CDK2/CDC20/ADCY6/ADCY2/SMC3/BUB1/RPS6KA3/IGF1/PLK1/AURKA/CDC25C/MAPK1/ADCY7/PPP2R5C/MAPK13/CALM2/PPP2R5E/PTTG1/ANAPC11/YWHAE/BTRC/YWHAG/CPEB4/PPP3R1/CDC23/ESPL1/ANAPC4	3.99185225973435
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	43/1390	170/9376	1.70617012272535	EGFR/MET/LRP5/CCND1/MGST3/IGF1R/CDKN2A/E2F1/FZD6/CDK6/FZD3/IGF2/HRAS/GSTA4/SMARCA2/GAB1/GSTP1/WNT4/PRKCB/FZD10/FZD5/AXIN2/CDK4/TGFBR2/LRP6/GSTM3/DVL3/E2F2/RB1/MAPK1/TCF7/TXNRD3/BRD7/SOS2/BAD/ACTL6A/FZD2/PIK3R3/WNT3/ARID1A/FZD8/GADD45A/AKT3	3.87638317508306
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	53/1390	224/9376	1.59599177800617	SLC2A1/MAD2L1/NRP1/CCND1/CHEK1/CCNE1/CCNE2/MSX2/SLC25A4/CCNA2/CDKN2A/E2F1/CCNB2/BUB1B/HRAS/CDK2/DLG1/FDPS/CREB5/CDC20/ADCY6/SLC25A5/ADCY2/MAP3K1/CD4/CDK4/TGFBR2/RANBP1/EP300/CALR/E2F2/LTBR/RB1/MAPK1/CREBBP/ADCY7/NFYB/EGR2/JAK3/RAN/PIK3R3/PTTG1/CHEK2/ANAPC11/NFATC2/ETS2/PPP3R1/CDC23/MMP7/ESPL1/ANAPC4/AKT3/IKBKG	3.76647125493724
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	12/1390	28/9376	2.89085303186023	HACD3/ELOVL4/TECR/HADH/ACOT4/ECHS1/ACOT7/PPT2/MECR/ELOVL2/THEM4/ELOVL6	4.18028434267029
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	55/1390	238/9376	1.55879330149326	RPS29/EGFR/RPS27/RPL37A/RPS28/RPL39/RPL36/NRP1/RPL37/RPS21/RPS17/RPLP0/RPSA/RPL34/RPLP2/RPL21/IL6ST/RPS15A/RPS12/RPL35/RPS5/RPS27A/RPS4Y1/RPS19/RPLP1/RPS23/PRKCB/RPS18/TLR3/RPS8/RPL31/RPS15/RPL18/RPL12/RPS7/RPL22/RPL32/RPS14/MAPK1/RPL23/TAB2/MAPK13/RPS16/RPL5/RPL38/C1QB/RPL27A/PIK3R3/RPL13A/F13A1/RPL23A/C1QA/RPS3/IRAK4/IKBKG	3.64285997830419
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	37/1390	144/9376	1.73317346123102	ISL1/DUSP9/ID4/ID1/TBX3/IGF1R/FZD6/IL6ST/FZD3/FGFR2/BMPR1A/HRAS/LIFR/DLX5/WNT4/BMP4/FZD10/FZD5/AXIN2/ACVR2B/IGF1/PCGF2/ID3/DVL3/SMAD5/MAPK1/TCF7/JAK3/PCGF6/MAPK13/FZD2/PIK3R3/WNT3/FZD8/FGF2/SMARCAD1/AKT3	3.69886490666671
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	50/1390	212/9376	1.59087824080358	CDH1/EGFR/MET/FLT1/PARD3/PARD6B/ID1/EFNA1/ITGB1/IGF1R/BCAR1/PFN2/GNAS/GNAI1/RAC3/EFNA5/FGFR2/HRAS/ENAH/EPHA2/PRKCZ/PRKCB/PDGFA/MAGI3/MAGI1/ADCY6/ADCY2/PARD6G/VAV3/IGF1/PDGFD/PRKCI/ANGPT1/MAPK1/ADCY7/TIAM1/CTNND1/GNAQ/MAPK13/RALGDS/FGF1/CALM2/INSR/CSF1R/PIK3R3/PLCE1/PRKD3/RAPGEF5/FGF2/AKT3	3.63037738284345
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	12/1390	29/9376	2.7911684445547	FRMD6/RASSF6/TEAD1/YAP1/WWC1/TEAD4/TEAD3/WWTR1/WTIP/RASSF4/AJUBA/CSNK1E	4.03021015116113
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	30/1390	110/9376	1.83963374754742	MAD2L1/CDK1/PKMYT1/CCNA2/IGF1R/CCNB2/GNAI1/CDC25A/CCNB1/CDK2/HSP90AA1/ADCY6/ADCY2/BUB1/KIF22/RPS6KA3/IGF1/PLK1/HSP90AB1/AURKA/CDC25C/MAPK1/ADCY7/MAPK13/PIK3R3/ANAPC11/CPEB4/CDC23/ANAPC4/AKT3	3.695459661191
Human Diseases	Cancer: specific types	hsa05218	Melanoma	22/1390	73/9376	2.03283729181039	CDH1/EGFR/MET/CCND1/IGF1R/CDKN2A/E2F1/CDK6/HRAS/PDGFA/CDK4/IGF1/PDGFD/E2F2/RB1/MAPK1/BAD/FGF1/PIK3R3/FGF2/GADD45A/AKT3	3.69581492730033
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	53/1390	233/9376	1.53434402692438	FBN2/FBN1/FBLN1/ITGB4/SYNE2/COL4A2/MYH10/ITGA6/DSG2/DAG1/DSP/DIAPH3/COL4A1/ANK3/ITGB5/PDLIM1/CSRP2/ITGB1/ITGB8/DMD/SGCE/FHL2/BGN/COL5A2/SPTBN1/DSC2/PKP2/SGCB/SSPN/FN1/INF2/LMNB2/ITGAV/ITGA3/TPM1/SDC4/LMNA/HSPG2/SDC1/NEBL/TNNC1/SUN1/TMOD2/LAMA1/ITGB6/DAAM1/ATP1A4/TTN/CAPZA1/COL1A1/COL1A2/COL6A1/JUP	3.44574349614022
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	37/1390	148/9376	1.6863309352518	EGFR/LRP5/CCND1/BRCA1/IGF1R/E2F1/FZD6/NOTCH3/CDK6/FZD3/BRCA2/HRAS/WNT4/NOTCH2/FZD10/FZD5/AXIN2/CDK4/ERBB2/LRP6/IGF1/JAG2/DVL3/E2F2/RB1/MAPK1/TCF7/SOS2/FGF1/JAG1/FZD2/PIK3R3/WNT3/FZD8/FGF2/GADD45A/AKT3	3.5110662533446
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	34/1390	133/9376	1.7243684751447	EGFR/CCND1/SKP2/IGF1R/CCNB2/FOXO4/HOMER1/HRAS/CCNB1/CDK2/PLK2/PRKAA2/TGFBR2/IGF1/EP300/PLK1/PLK4/IRS1/BNIP3/RBL2/MAPK1/CREBBP/MAPK13/SOS2/FOXO3/PRKAB2/INSR/PIK3R3/FOXO6/CSNK1E/GADD45A/PCK2/AKT3/SIRT1	3.51000124666993
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	37/1390	150/9376	1.66384652278177	CDH1/EGFR/MET/LRP5/CCND1/CCNE1/CCNE2/E2F1/FZD6/ABCB1/FZD3/FGFR2/HRAS/GAB1/CDK2/WNT4/FZD10/FZD5/AXIN2/TGFBR2/ERBB2/LRP6/DVL3/E2F2/RB1/MAPK1/TCF7/SOS2/FGF1/FZD2/PIK3R3/WNT3/JUP/FZD8/FGF2/GADD45A/AKT3	3.41928242923769
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	42/1390	178/9376	1.59159324226012	LGR5/NOTUM/RNF43/LGR4/LRP5/CCND1/SERPINF1/ZNRF3/TLE1/FZD6/RAC3/FZD3/CAMK2G/CBY1/WNT4/PRKCB/SIAH1/BAMBI/FZD10/FZD5/AXIN2/TBL1X/LRP6/EP300/APCDD1/DVL3/PSEN1/TCF7/CREBBP/RUVBL1/DAAM1/TLE2/FZD2/WNT3/NFATC2/CSNK1E/FZD8/BTRC/PPP3R1/CTBP1/MMP7/SIRT1	3.32441236027339
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	17/1390	54/9376	2.12352784439115	CDO1/LDHB/GCLM/PHGDH/DNMT1/CISD1/PSAT1/MTAP/ADI1/DNMT3A/MTR/SRM/BCAT2/SMS/GOT2/LACC1/GOT1	3.45425628149756
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	21/1390	73/9376	1.9404355967281	EGFR/MET/CCND1/CDKN2A/E2F1/CDK6/HRAS/PRKCB/CDK4/ERBB2/E2F2/RB1/MAPK1/JAK3/FHIT/SOS2/BAD/FOXO3/PIK3R3/GADD45A/AKT3	3.36517275674664
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	26/1390	99/9376	1.77149916430492	EGFR/CCND1/IGF1R/CDKN2A/E2F1/GNAS/PTK2/NOTCH3/HRAS/NOTCH2/ADCY6/ADCY2/CDK4/ERBB2/IGF1/JAG2/E2F2/RB1/MAPK1/ADCY7/MAPK13/SOS2/BAD/JAG1/PIK3R3/AKT3	3.21942019771973
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	17/1390	56/9376	2.04768756423433	TUSC3/FUT8/RPN2/MGAT3/DDOST/ALG10B/GANAB/ALG14/ALG8/MAN1C1/STT3A/ALG6/KRTCAP2/ALG10/B4GALT2/DOLPP1/ST6GAL1	3.28054675439639
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	17/1390	57/9376	2.01176322100215	HACD3/ELOVL4/TECR/FASN/ACAT2/ACADL/HADH/ECHS1/CPT2/PPT2/MECR/ELOVL2/ACADVL/ACACA/ACADSB/ACADS/ELOVL6	3.19639207717089
NA	NA	hsa04981	Folate transport and metabolism	11/1390	31/9376	2.39350197261546	TYMS/FOLR1/DHFR/SLC19A1/SHMT1/MTR/MTHFD1/SLC46A1/FOLR3/ABCG2/FOLR2	3.242105681769
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	22/1390	86/9376	1.72554793374603	ITGB4/ITGA6/DSG2/DAG1/GJA1/DSP/ITGB5/ITGB1/ITGB8/DMD/SGCE/DSC2/PKP2/SGCB/SSPN/ITGAV/ITGA3/LMNA/TCF7/LAMA1/ITGB6/JUP	2.81991399990883
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	35/1390	155/9376	1.52313761893711	EGFR/PBX1/CCND1/CCNE1/CCNE2/CDKN2A/E2F1/FZD6/GNAS/GNAI1/CDK6/FZD3/CAMK2G/GNA11/CDK2/WNT4/CREB5/FZD10/FH/ADCY6/FZD5/ADCY2/AXIN2/CDK4/DVL3/E2F2/RB1/MAPK1/TCF7/ADCY7/GNAQ/FZD2/WNT3/WDR5/FZD8	2.73981459500041
Human Diseases	Cancer: specific types	hsa05214	Glioma	20/1390	76/9376	1.77508519500189	EGFR/CCND1/IGF1R/CDKN2A/E2F1/CDK6/CAMK2G/HRAS/PRKCB/PDGFA/CDK4/IGF1/E2F2/RB1/MAPK1/SOS2/CALM2/PIK3R3/GADD45A/AKT3	2.83036958520399
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	20/1390	77/9376	1.75203214052135	EGFR/RAD51/CCND1/CDKN2A/E2F1/CDK6/RAC3/BRCA2/CDK4/TGFBR2/ERBB2/E2F2/RB1/MAPK1/RALGDS/BAD/PIK3R3/GADD45A/AKT3/IKBKG	2.76434361574982
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	20/1390	77/9376	1.75203214052135	CCND1/CDKN2A/E2F1/CDK6/HRAS/CDK4/TGFBR2/RUNX1/E2F2/RB1/MAPK1/SOS2/BAD/BCR/PIK3R3/HDAC2/GADD45A/CTBP1/AKT3/IKBKG	2.76434361574982
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	35/1390	158/9376	1.49421728440033	LRP5/ATP6V1C2/ATP6V1B1/SKP2/IGF1R/FZD6/FZD3/SLC38A9/PRR5/HRAS/WNT4/PRKCB/FZD10/FZD5/PRKAA2/RPS6KA3/LRP6/IGF1/DVL3/IRS1/MAPK1/SOS2/ATP6V1C1/CAB39/EIF4B/FZD2/INSR/TTI1/CLIP1/PIK3R3/WNT3/SESN2/FZD8/CAB39L/AKT3	2.61370462895662
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	20/1390	78/9376	1.72957019000184	CDH1/MET/ITGB1/BCAR1/PTK2/DOCK1/GAB1/CLTC/ARPC5L/FN1/CTTN/WASF1/ELMO3/CAV2/ARHGAP10/ACTR3C/PIK3R3/WASF2/CAV1/WASL	2.69928036993446
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	12/1390	39/9376	2.07548422800221	GLDC/TYMS/ALDH7A1/DHFR/GCSH/CHDH/ATIC/SHMT1/MTR/MTHFD1/AMT/GART	2.80776693484092
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	24/1390	99/9376	1.63522999781993	EGFR/PLPP3/RAC3/SLC44A2/HRAS/PRKCB/SLC44A5/PDGFA/PIP5K1B/WASF1/CHPT1/PDGFD/DGKZ/SLC44A3/MAPK1/SLC44A1/SOS2/RALGDS/SLC22A5/DGKD/PIK3R3/WASF2/PLA2G4A/AKT3	2.6507770582246
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	26/1390	110/9376	1.59434924787443	FBN1/BMP7/LTBP1/ID4/ID1/BMPR1A/TFRC/BMP4/RBL1/BAMBI/THSD4/TGFBR2/ACVR2B/EP300/ID3/ZFYVE9/SMAD5/TFDP1/MAPK1/CREBBP/E2F5/RGMB/NEO1/E2F4/RGMA/HDAC2	2.61589493823331
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	22/1390	89/9376	1.66738339665346	EGFR/GJA1/ADRB1/CDK1/TJP1/GNAS/TUBB/GNAI1/HRAS/TUBA1B/GNA11/PRKCB/PDGFA/ADCY6/ADCY2/TUBB4B/PDGFD/TUBA1C/MAPK1/ADCY7/GNAQ/SOS2	2.63913170389628
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	16/1390	59/9376	1.82924033654432	TYMS/RRM2/TK1/RRM1/DUT/DTYMK/UMPS/ENTPD1/NME4/DCTPP1/CTPS1/NME6/NME1/UCK1/TK2/DHODH	2.66561094347467
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	21/1390	85/9376	1.66649174777825	TYMS/RRM2/TK1/RRM1/DUT/DTYMK/AK3/ENTPD1/NME4/DCTPP1/IMPDH2/ADK/PNP/CTPS1/NME6/NME1/GMPS/UCK1/AK5/TK2/LACC1	2.57514326053304
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	20/1390	80/9376	1.6863309352518	EGFR/MET/ERBB3/IGF1R/FGFR2/HRAS/GAB1/PRKCB/PDGFA/ERBB2/IGF1/NF1/PDGFD/MAPK1/SOS2/BAD/FOXO3/PIK3R3/FGF2/AKT3	2.57192852873793
NA	NA	hsa04517	IgSF CAM signaling	59/1390	299/9376	1.33101705926229	CDH1/MYH10/PTPRF/LMO7/CNTNAP2/JAM3/NRP1/PARD3/ANK3/APP/TJP1/NRP2/RASA1/PARD6B/CADM1/ITGB1/SORBS1/BCAR1/PAK6/PTK2/TUBB/MPDZ/NRCAM/SPTBN1/DYNLL2/TUBA1B/NLGN4X/INPP5D/PRKCB/GRIP1/ARPC5L/BAIAP2/MAGI1/PLXNA1/PLXNA2/TUBB4B/PARD6G/SRGAP1/VAV3/TUBA1C/PRKCI/NLGN1/CD84/MAPK1/IL1RAPL2/RDX/CD28/ACTR3C/SSX2IP/MAPK13/NCK2/CASKIN2/TJP2/PIK3R3/IQGAP1/PAK4/WASL/AKT3/SRGAP2	2.42685141870884
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	19/1390	75/9376	1.70881534772182	TOP2A/BIRC5/BRCA1/MGST3/MSH2/CDKN2A/ATP7B/GSTA4/MSH6/GSTP1/ERBB2/GSTM3/MAPK1/PMAIP1/BAD/PIK3R3/ATP7A/AKT3/REV3L	2.571149369705
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	14/1390	50/9376	1.88869064748201	ALDH7A1/AOC1/CKMT1B/CKMT1A/ALDH18A1/GAMT/PYCR2/SRM/ALDH4A1/ARG2/SMS/GOT2/OAT/GOT1	2.62855029764498
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	12/1390	41/9376	1.97424109492893	CDH1/EGFR/CCND1/CDKN2A/E2F1/HRAS/CDK4/ERBB2/E2F2/RB1/MAPK1/RPS6KA5	2.60813217868677
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	16/1390	62/9376	1.7407287073567	IGF1R/HRAS/ADCY6/PRKAA2/ADCY2/SOD1/IGF1/IRS1/ADCY7/FOXO3/PRKAB2/INSR/PIK3R3/HDAC2/AKT3/SIRT1	2.44126705112146
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	20/1390	83/9376	1.62537921470053	EZH2/AURKB/RBBP7/TEX10/CBX4/AUTS2/SCML2/EP300/PCGF2/SUZ12/TFDP1/SFMBT1/CREBBP/PCGF6/EED/RBBP4/AEBP2/HDAC2/WDR5/EZH1	2.38744241824754
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	41/1390	200/9376	1.38279136690647	MYH10/CLDN4/TJP1/CLDN7/ITGB1/TUBB/NCKAP1/MYO6/MYO1D/TUBA1B/MYO1C/OCLN/ARPC5L/BAIAP2/CTTN/CLDN3/CYTH4/MYO5B/MYO5C/TLR5/TUBB4B/WASF1/BAIAP2L1/CYTH3/ARHGEF1/CLDN19/TUBA1C/GNA12/MAPK1/MYO5A/ARHGEF12/CYFIP2/TAB2/ACTR3C/MAPK13/NCK2/WASF2/RPS3/IRAK4/WASL/IKBKG	2.28285756543257
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	24/1390	105/9376	1.54178828365879	ITGB4/ITGA6/DAG1/ADRB1/ITGB5/ITGB1/ITGB8/DMD/SGCE/GNAS/SGCB/SSPN/ITGAV/ADCY6/ITGA3/TPM1/ADCY2/IGF1/LMNA/TNNC1/ADCY7/LAMA1/ITGB6/TTN	2.3291065323703
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	12/1390	43/9376	1.88241592772294	ALDH7A1/ACAT2/ACADL/HADH/ADH5/ECI2/ECI1/ECHS1/CPT2/ACADVL/ACADSB/ACADS	2.41949828635017
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	13/1390	48/9376	1.82685851318945	ALDH7A1/ACAT2/HADH/OXCT1/ECHS1/PCCB/BCAT2/HIBADH/MCCC2/HIBCH/AUH/ACADSB/ACADS	2.39599516623405
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	7/1390	20/9376	2.36086330935252	DHCR24/SQLE/LIPA/FDFT1/TM7SF2/MSMO1/SOAT1	2.54163265536485
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	23/1390	101/9376	1.53606382220956	FZD6/GNAS/GNAI1/FZD3/CAMK2G/HRAS/WNT4/PRKCB/FZD10/ADCY6/FZD5/ADCY2/EP300/DVL3/MAPK1/TCF7/CREBBP/ADCY7/GNAQ/CALM2/FZD2/WNT3/FZD8	2.25968868916651
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	47/1390	238/9376	1.33205973036697	EGFR/MET/FLT1/RASA1/GNG12/EFNA1/IGF1R/PAK6/FOXO4/RAC3/EFNA5/FGFR2/IGF2/HRAS/RRAS2/EPHA2/GAB1/PRKCB/PDGFA/IGF1/NF1/PDGFD/GNG2/ANGPT1/MAPK1/BDNF/TIAM1/NTF4/SOS2/RALGDS/BAD/FGF1/CALM2/INSR/CSF1R/PIK3R3/RASAL2/PLCE1/PAK4/PLA2G12A/ETS2/PLA2G4A/RAPGEF5/FGF2/GNG7/AKT3/IKBKG	2.16474875222694
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	15/1390	59/9376	1.7149128155103	GPX8/RRM2/RRM1/MGST3/GGCT/GCLM/GSTA4/GSTP1/IDH1/IDH2/GSTM3/SRM/GGT7/SMS/GPX7	2.29810266176396
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	30/1390	142/9376	1.42506839598744	BRCA1/UBE2C/SKP2/DDB1/RPS27A/RHOBTB1/UBE4B/WWP1/SIAH1/NEDD4/CDC20/MAP3K1/FANCL/SAE1/UBE2W/HERC2/TRIM37/UBA7/FBXO4/MID1/TRIP12/ANAPC11/PIAS1/PRPF19/BTRC/FBXW8/UBE2S/CDC23/ANAPC4/UBE2J1	2.12929796323255
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	30/1390	142/9376	1.42506839598744	CTSL/GPC1/HSP90B1/MGST3/ASS1/PTK2/RAC3/BMPR1A/GSTA4/GSTP1/PRKCZ/BMP4/HSP90AA1/PDGFA/ITGAV/PRKAA2/SDC4/ACVR2B/CAV2/GSTM3/HSP90AB1/TRPV4/SDC1/MEF2C/MAPK13/CALM2/PIK3R3/CAV1/AKT3/IKBKG	2.12929796323255
Cellular Processes	Cell motility	hsa04814	Motor proteins	39/1390	194/9376	1.35601869020248	MYH10/KIF23/KIF21A/MYO7A/TUBB/KIFC1/KIF4A/MYO6/DYNLL2/MYO1D/KIF2C/TUBA1B/KIF11/MYO1C/KIF15/TUBG1/KIF14/KIF20B/MYO5B/TPM1/MYO5C/TUBB4B/DNAH14/KIF22/TUBA1C/CENPE/KIFC3/KIF18A/KIF24/MYO5A/TNNC1/KIF18B/MYO19/HOOK3/CAPZA1/ACTA2/KIF20A/KIF26B/DYNC2LI1	2.09041928953396
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	32/1390	154/9376	1.40162571241708	GGH/QPRT/DHFR/GCLM/MOCS1/PSAT1/AK3/UMPS/ALAD/NME4/SHMT1/COQ4/MMAB/MTHFD1/CTPS1/MOCS2/BCAT2/COQ3/HMBS/GGCX/PTS/NME6/NME1/PMM1/PHOSPHO2/LIPT2/RDH13/UGP2/PANK1/AK5/PMM2/DHODH	2.09651365696771
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	6/1390	17/9376	2.38070249682607	MYH10/DAG1/NRP2/PCDH11X/TFRC/PCDH11Y	2.37704953851974
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/1390	31/9376	1.95831979577628	GLDC/ACSS1/GCSH/ACAT2/PGP/SHMT1/PCCB/ACO1/AMT	2.22961582824783
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	48/1390	250/9376	1.29510215827338	EGFR/FOLR1/PARD3/PARD6B/IGF1R/EPN2/FGFR2/DAB2/HRAS/TFRC/AGAP1/EPN3/SH3GLB2/CHMP4C/CLTC/PRKCZ/ACAP2/WWP1/ARPC5L/EHD3/NEDD4/CYTH4/MVB12B/DNAJC6/TGFBR2/PARD6G/PIP5K1B/CYTH3/CAV2/LDLRAP1/ARAP2/RAB11FIP4/PRKCI/ZFYVE9/GIT2/ACTR3C/ASAP2/PDCD6IP/BIN1/PSD3/EHD4/FOLR3/CAPZA1/CAV1/EPS15/AP2A2/WASL/FOLR2	1.97301570999377
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	10/1390	37/9376	1.82306047054249	ASS1/RIMKLB/PPAT/GFPT1/ALDH5A1/ALDH4A1/NIT2/GOT2/GLUD2/GOT1	2.09271845334017
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	15/1390	63/9376	1.60602946214457	ALDH7A1/EZH2/PLOD2/SMYD2/ACAT2/DHTKD1/HADH/SUV39H2/ECHS1/KMT5C/AASS/SETDB2/SETMAR/KMT5B/EZH1	2.01348128178828
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	15/1390	63/9376	1.60602946214457	GLI3/FZD6/FZD3/WNT4/BMP4/FZD10/FZD5/AXIN2/DVL3/TCF7/PTCH1/FZD2/WNT3/FZD8/GADD45A	2.01348128178828
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	14/1390	59/9376	1.60058529447628	CDH1/EGFR/CCND1/HRAS/AXIN2/ERBB2/MAPK1/TCF7/SOS2/BAD/FOXO3/PIK3R3/GADD45A/AKT3	1.93059438005325
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	16/1390	70/9376	1.54178828365879	MET/SLC2A1/EPAS1/PAK6/HRAS/GAB1/FH/EP300/MAPK1/CREBBP/SOS2/BAD/EGLN1/PIK3R3/PAK4/AKT3	1.89812797676397
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	24/1390	115/9376	1.40771973725368	EGFR/LRP5/GATA3/MMP15/GNAS/GNAI1/SLC34A2/WNK2/GNA11/PRKCB/CREB5/ADCY6/ADCY2/LRP6/ARHGEF1/GNA12/MEF2C/MAPK1/GCM1/ADCY7/PDE4D/GNAQ/WNK1/MMP14	1.83531282378843
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	21/1390	99/9376	1.43082624809244	ITGB4/ITGA6/DAG1/ITGB5/ITGB1/ITGB8/DMD/SGCE/SGCB/SSPN/ITGAV/ITGA3/PRKAA2/TPM1/IGF1/LMNA/TNNC1/LAMA1/ITGB6/TTN/PRKAB2	1.7978123489819
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	25/1390	122/9376	1.38223847151787	SLC2A1/CCND1/SLC16A2/NOTCH3/SLC9A1/HRAS/WNT4/BMP4/NOTCH2/PRKCB/MED12L/ITGAV/EP300/MED13L/THRB/MAPK1/CREBBP/ATP1A4/BAD/PIK3R3/PLCE1/HDAC2/MED16/TBC1D4/AKT3	1.77287431834415
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	25/1390	122/9376	1.38223847151787	BCAR1/GNAS/PTK2/GNAI1/HRAS/GNA11/PRKCB/CREB5/SOCS2/ADCY6/CSH2/ADCY2/MAP3K1/GHR/IGF1/EP300/IRS1/MAPK1/CREBBP/ADCY7/GNAQ/MAPK13/SOS2/PIK3R3/AKT3	1.77287431834415
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	31/1390	157/9376	1.33187921000779	SLC2A1/PBX1/CD24/ITGB5/TMEM30B/BCAR1/BSG/PTK2/SLC16A1/CAMK2G/DOCK1/DUSP5/RAB17/ITGAV/GULP1/PPARG/DUSP4/LIPA/DNMT3A/CALR/CX3CR1/MAPK1/ARG2/ADAM10/TYRO3/MAPK13/C1QB/NFATC2/TGFBRAP1/C1QA/SIRT1	1.74950968801512
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	26/1390	128/9376	1.37014388489209	RRM2/RRM1/PAICS/PPAT/AK3/PDE10A/ATIC/ENTPD1/NME4/ADCY6/ADCY2/IMPDH2/ADK/PNP/ADCY7/PDE4D/NME6/FHIT/NME1/GMPS/NUDT5/PAPSS2/PGM1/AK5/GART/LACC1	1.75905751068484
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	14/1390	62/9376	1.52313761893711	TLE1/NOTCH3/NOTCH2/DTX4/EP300/JAG2/DVL3/PSEN1/CREBBP/TLE2/JAG1/ATXN1/HDAC2/CTBP1	1.72413816236544
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	10/1390	41/9376	1.64520091244078	GLDC/ALDH7A1/GCSH/PHGDH/PSAT1/CHDH/GAMT/SHMT1/GCAT/AMT	1.72726162981003
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	27/1390	138/9376	1.31973725367532	ITGB1/BCAR1/PTK2/RAC3/DOCK1/ARPC5L/BAIAP2/FN1/CD4/PIP5K1B/VAV3/RPS6KA3/ARHGEF1/MAPK1/GIT2/ARHGEF12/TAB2/ACTR3C/GNAQ/MAPK13/PIK3R3/WASF2/NFATC2/IRAK4/WASL/AKT3/IKBKG	1.57860033266724
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/1390	21/9376	1.92723535457348	CHPF/CHST14/CHST3/DSEL/CHST12/XYLT1	1.77462305494888
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	7/1390	26/9376	1.81604869950194	SLC19A3/SLC19A1/SLC5A6/SLC52A3/SLC46A1/SLC19A2/PLB1	1.73830240469188
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	16/1390	75/9376	1.43900239808153	ASS1/PHGDH/RPIA/PSAT1/ALDH18A1/SHMT1/IDH1/IDH2/MTR/PYCR2/BCAT2/ARG2/GOT2/PC/ACO1/GOT1	1.59243270162556
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	38/1390	205/9376	1.25035269345499	CDK1/CCND1/CHEK1/SCIN/CCNE1/CCNE2/CCNA2/SKP2/CDKN2A/IL6ST/DDB1/CDK6/HRAS/CDK2/RBL1/DLG1/CREB5/CDC20/CDK4/RANBP1/EP300/RBL2/LTBR/RB1/MAPK1/DNAJA3/CREBBP/EGR2/JAK3/PMAIP1/BAD/PIK3R3/SND1/HDAC2/GSN/YWHAE/YWHAG/IKBKG	1.51199110900669
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	31/1390	163/9376	1.28285298141855	BIRC5/CCNE1/CCNE2/PCNA/CCNA2/E2F1/DDB1/HRAS/CDK2/PRKCB/CREB5/TLR3/MAP3K1/TGFBR2/EP300/HSPG2/E2F2/RB1/MAPK1/CREBBP/EGR2/TAB2/JAK3/MAPK13/SOS2/BAD/PIK3R3/NFATC2/IRAK4/AKT3/IKBKG	1.51978590643062
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	23/1390	116/9376	1.33743487968246	GLDC/ACSS1/GCSH/PHGDH/ACAT2/RPIA/PSAT1/PGP/FH/SHMT1/ADH5/IDH1/IDH2/ECHS1/PCCB/HIBCH/GOT2/GLUD2/PC/ACO1/ACADS/AMT/GOT1	1.52560414158773
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	18/1390	87/9376	1.39558422227735	EGFR/BIRC5/CCND1/MSH2/RAC3/HRAS/MSH6/AXIN2/TGFBR2/MAPK1/TCF7/PMAIP1/SOS2/RALGDS/BAD/PIK3R3/GADD45A/AKT3	1.54647353359847
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	24/1390	122/9376	1.32694893265715	CCND1/CCNA2/IGF1R/PPP2R2B/FASN/CREB5/PPP2R3B/PPARG/PRKAA2/IGF1/IRS1/PPP2R5C/ACACA/FOXO3/CAB39/PRKAB2/INSR/PIK3R3/PPP2R5E/CAB39L/PCK2/AKT3/PPP2R3A/SIRT1	1.51643387390116
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	9/1390	37/9376	1.64075442348824	GFPT1/UXS1/PGM3/GALE/GNPNAT1/PMM1/PGM1/UGP2/PMM2	1.62918601255308
NA	NA	hsa03272	Virion - Hepatitis viruses	11/1390	48/9376	1.54580335731415	EGFR/DPP4/CLDN4/CLDN7/OCLN/EPCAM/CLDN3/CLDN19/HSPG2/PDCD6IP/TGOLN2	1.58157917585519
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	45/1390	250/9376	1.21415827338129	CTSV/CTSL/ATP6V1C2/ATP6V1B1/MCOLN3/AP1S3/AP1M2/SLC29A1/SLC38A9/SLC29A2/CLTC/FUCA1/LGMN/CTSF/TLR3/LIPA/LAPTM4B/VPS13A/AP1S1/ABCA5/CLN6/SLC15A3/NAGLU/PPT2/ATP6V0A4/SMPD1/ATP6V0A1/AP3M2/CLCN7/ATP6V1C1/TPP1/GNPTG/GNS/TTI1/OSTM1/ARSB/CTBS/ATP6V0E2/HYAL2/AP3B1/CLN3/GGA1/SPG11/AP2A2/GPR155	1.43183513220869
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	7/1390	27/9376	1.74878763655742	ACAT2/HADH/OXCT1/ECHS1/ALDH5A1/ACADS/L2HGDH	1.6254976748897
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1390	27/9376	1.74878763655742	HACD3/ELOVL4/TECR/ACOT4/ACOT7/ELOVL2/ELOVL6	1.6254976748897
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	67/1390	388/9376	1.16478528517392	MME/MT-ND3/LRP5/APP/MT-ND6/SLC25A4/SLC39A10/FZD6/UQCRQ/TUBB/NAE1/FZD3/COX6C/HRAS/TUBA1B/BACE2/WNT4/COX6A1/SLC39A1/FZD10/PSMD1/FZD5/SLC25A5/AXIN2/PSMB5/COX7C/TUBB4B/UQCR10/PSMD7/PSMD14/LRP6/SLC39A7/TUBA1C/NDUFV1/DVL3/IRS1/NDUFA10/PSMC3/MAPK1/PSEN1/COX7A1/NDUFA6/COX7A2/NDUFB1/ADAM10/MT-CO2/GNAQ/PSMA8/BAD/CALM2/FZD2/INSR/PSMD11/PIK3R3/WNT3/GRIN2C/CSNK1E/FZD8/NDUFV3/MT-ND4L/PPP3R1/NDUFA3/PSMB6/PSMA3/AKT3/CHRM3/IKBKG	1.38302854632745
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	9/1390	38/9376	1.5975766755017	GFPT1/UXS1/PGM3/GALE/GNPNAT1/PMM1/PGM1/UGP2/PMM2	1.5398800296367
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/1390	28/9376	1.6863309352518	ATP6V1C2/ATP6V1B1/ATP6V0A4/ATP6V0A1/ATP6V1C1/SLC12A7/ATP6V0E2	1.51733551692316
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	18/1390	90/9376	1.34906474820144	IGF1R/HRAS/CREB5/ADCY6/PPARG/PRKAA2/ADCY2/IGF1/IRS1/SESN1/ADCY7/FOXO3/PRKAB2/INSR/PIK3R3/SESN2/AKT3/SIRT1	1.38816564603874
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/1390	23/9376	1.75964967156709	ACAT2/ICMT/PCYOX1/FDPS/PMVK/MVK	1.52170402951766
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	37/1390	205/9376	1.21744867520618	SLC2A1/MT-ND3/MT-ND6/SLC25A4/PARP1/UQCRQ/CAMK2G/COX6C/GFPT1/PRKCZ/PRKCB/COX6A1/MPC2/SLC25A5/COX7C/UQCR10/TGFBR2/CPT2/NDUFV1/IRS1/NDUFA10/COX7A1/NDUFA6/COX7A2/NDUFB1/MT-CO2/MAPK13/INSR/COL1A1/PIK3R3/COL1A2/PDK2/NDUFV3/MT-ND4L/TBC1D4/NDUFA3/AKT3	1.31326912860289
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	20/1390	103/9376	1.30977160019557	LAMB1/LAMA5/COL4A2/LAMC1/COL4A1/GNAS/PTK2/GNA11/PRKCB/FN1/LAMB4/LAMC2/PRDX1/ARG2/LAMB2/LAMA1/GNAQ/COL1A1/PIK3R3/COL1A2	1.31879856851289
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	26/1390	140/9376	1.25270298047276	CDH1/CCND1/GNG12/GNAI1/NOTCH3/SLC9A1/HRAS/RRAS2/TFAM/ADCY6/PRKAA2/ADCY2/PIK3R5/GNG2/MEF2C/MAPK1/ADCY7/SERPINE1/GNAQ/APELA/JAG1/PRKAB2/CALM2/ACTA2/GNG7/AKT3	1.2567844693547
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	19/1390	98/9376	1.30776684774629	SCIN/PLPP3/DOCK1/INPP5D/PRKCB/ARPC5L/PIP5K1B/VAV3/WASF1/MAPK1/ACTR3C/ASAP2/BIN1/LIMK2/PIK3R3/WASF2/GSN/PLA2G4A/AKT3	1.27772112595924
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	21/1390	110/9376	1.28774362328319	EGFR/SLC2A1/FLT1/EPAS1/IGF1R/LDHB/CAMK2G/TFRC/PRKCB/ERBB2/IGF1/EP300/LTBR/ANGPT1/MAPK1/CREBBP/SERPINE1/EGLN1/INSR/PIK3R3/AKT3	1.26643903453621
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	38/1390	214/9376	1.19776776709474	CDK1/WEE1/CHEK1/GNG12/AP1S3/AP1M2/PAK6/CCNB2/PTK2/GNAI1/DDB1/RAC3/HRAS/GNA11/CCNB1/PRKCB/CD4/AP1S1/CALR/GNG2/CDC25C/MAPK1/TAB2/GNAQ/MAPK13/BAD/LIMK2/CALM2/PDIA3/PIK3R3/PAK4/NFATC2/IRAK4/BTRC/PPP3R1/GNG7/AKT3/IKBKG	1.22094370062502
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	15/1390	75/9376	1.34906474820144	LRP2/GPX8/HSP90B1/GNAS/PRKCB/CREB5/ADCY6/ADCY2/HSPA5/PDIA4/ADCY7/GNAQ/ATP1A4/DUOX1/GPX7	1.26619381226575
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	11/1390	52/9376	1.42689540675152	HSD17B1/IGF1R/GNAS/ADCY6/ADCY2/ACOT4/IGF1/CYP2J2/ADCY7/INSR/PLA2G4A	1.28780588904938
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	18/1390	93/9376	1.30554653051752	EGFR/GNAS/CAMK2G/HRAS/GNA11/PRKCB/ADCY6/ADCY2/MAP3K1/MAP3K4/MAPK1/ADCY7/GNAQ/MAPK13/SOS2/CALM2/MMP14/PLA2G4A	1.23538704033286
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1390	19/9376	1.77508519500189	GLDC/GCSH/DHTKD1/LIPT2/AMT	1.41086777025181
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	29/1390	160/9376	1.22258992805755	CDH1/CLDN4/ITGA6/PTPRF/CNTNAP2/JAM3/CLDN7/CADM1/ITGB1/ITGB8/CDH3/PTPRM/NRCAM/OCLN/NLGN4X/NRXN3/ITGAV/CLDN3/CD4/SDC4/CLDN19/NLGN1/SDC1/SIGLEC1/CD28/CDH4/NEO1/CD276/LRRC4	1.18473891193853
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	24/1390	130/9376	1.24529053680133	EGFR/COL4A2/COL4A1/GNG12/GNAS/GNAI1/HRAS/PRKCZ/CREB5/ADCY6/ADCY2/TGFBR2/GNG2/MAPK1/RLN2/ADCY7/MAPK13/SOS2/COL1A1/PIK3R3/ACTA2/COL1A2/GNG7/AKT3	1.17490813445807
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	16/1390	82/9376	1.31616072995262	RRM2/TK1/RRM1/MGST3/DUT/GSTA4/UMPS/GSTP1/NME4/IMPDH2/GSTM3/NME6/NME1/GMPS/UCK1/TK2	1.19961504304159
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	10/1390	47/9376	1.43517526404408	ACSS1/ALDH7A1/LDHB/ACAT2/FH/ADH5/ACYP1/ACACA/PC/PCK2	1.24773963060088
NA	NA	hsa04382	Cornified envelope formation	38/1390	217/9376	1.18120876570633	ITGB4/LAMA5/COL4A2/CLDN4/ITGA6/DSG2/DSP/KRT7/COL4A1/PRSS8/TJP1/CLDN7/KRT18/KRT8/EPHX2/ELOVL4/PKP3/PPP2R2B/PCSK6/PKP2/OCLN/S100A13/KRT23/KRT80/SPTLC3/PPP2R3B/CLDN3/LAMC2/CLDN19/BLMH/PPP2R5C/KAZN/KRT19/SLC27A1/PPP2R5E/ABCA12/JUP/PPP2R3A	1.12671331076624
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	12/1390	59/9376	1.37193025240824	ADRB1/GNAS/GNAI1/ADCY6/ADCY2/MGLL/IRS1/ADCY7/PTGS1/INSR/PIK3R3/AKT3	1.19557781663183
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	46/1390	268/9376	1.15777944808332	MT-ND3/MT-ND6/SLC25A4/SLC39A10/GNAS/UQCRQ/TUBB/GNAI1/CAMK2G/COX6C/TUBA1B/RPS27A/GPR37/COX6A1/SLC39A1/PSMD1/TRAP1/SLC25A5/PSMB5/COX7C/TUBB4B/UQCR10/PSMD7/PSMD14/HSPA5/SOD1/SLC39A7/TUBA1C/NDUFV1/NDUFA10/PSMC3/COX7A1/NDUFA6/COX7A2/NDUFB1/MT-CO2/PSMA8/UBA7/CALM2/PSMD11/NDUFV3/MT-ND4L/NDUFA3/PSMB6/PSMA3/UBE2J1	1.09328830890261
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	51/1390	300/9376	1.14670503597122	EGFR/MET/FLT1/DUSP9/RASA1/GNG12/EFNA1/STMN1/ERBB3/IGF1R/RAC3/EFNA5/FGFR2/IGF2/HRAS/RRAS2/EPHA2/DUSP5/PRKCB/PDGFA/DUSP4/MAP3K1/TGFBR2/ERBB2/RPS6KA3/MAP3K4/DUSP3/IGF1/NF1/PDGFD/GNA12/ANGPT1/MEF2C/MAPK1/BDNF/TAB2/NTF4/RPS6KA5/MAPK13/SOS2/FGF1/INSR/CSF1R/MAP3K11/PLA2G4A/IRAK4/FGF2/GADD45A/PPP3R1/AKT3/IKBKG	1.07742436215027
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	22/1390	120/9376	1.23664268585132	MAGED1/CAMK2G/HRAS/GAB1/SH2B3/MAP3K1/RPS6KA3/IRS1/MAPK1/BDNF/PSEN1/NTF4/RPS6KA5/MAPK13/SOS2/BAD/FOXO3/CALM2/PIK3R3/YWHAE/IRAK4/AKT3	1.08842979379022
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/1390	60/9376	1.34906474820144	PTK2/RAC3/HRAS/PRKCB/MAPK1/MAPK13/BAD/PIK3R3/NFATC2/PLA2G4A/PPP3R1/AKT3	1.13160605495761
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	20/1390	108/9376	1.24913402611244	RANBP17/MAGOHB/CSE1L/IPO5/NUP155/NXT1/NDC1/AAAS/TNPO1/RAN/UPF3A/NUP160/NUP50/THOC3/NUP37/NUP35/NUP205/NUP107/IPO7/UPF1	1.086376336062
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	52/1390	308/9376	1.13882089133888	GPX8/MT-ND3/MT-ND6/POLR2L/SLC25A4/UQCRQ/TUBB/TGM2/COX6C/TUBA1B/TFAM/CLTC/COX6A1/CREB5/PSMD1/PPARG/SLC25A5/PSMB5/COX7C/TUBB4B/UQCR10/PSMD7/DNAH14/PSMD14/POLR2I/SOD1/EP300/TUBA1C/TAF4B/NDUFV1/NDUFA10/PSMC3/BDNF/COX7A1/CREBBP/NDUFA6/POLR2H/COX7A2/NDUFB1/MT-CO2/POLR2D/GNAQ/PSMA8/GPX7/PSMD11/HDAC2/NDUFV3/MT-ND4L/NDUFA3/AP2A2/PSMB6/PSMA3	1.03348176088764
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1390	37/9376	1.45844837643399	CDH1/CCND1/HRAS/PPARG/MAPK1/TCF7/TFG/GADD45A	1.16565357176599
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	39/1390	227/9376	1.15888821982062	EGFR/CCND1/GNG12/CDKN2A/BCAR1/E2F1/GNAS/PTK2/GNAI1/CDK6/RAC3/HRAS/GNA11/PRKCB/CREB5/ITGAV/ADCY6/ADCY2/CDK4/ARHGEF1/CALR/GNA12/E2F2/GNG2/RB1/MAPK1/ADCY7/ARHGEF12/GNAQ/MAPK13/SOS2/CALM2/PDIA3/PIK3R3/NFATC2/PPP3R1/GNG7/AKT3/IKBKG	1.01098846257452
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	39/1390	227/9376	1.15888821982062	EGFR/MET/SLC26A2/MT-ND3/MT-ND6/SLC25A4/MGST3/UQCRQ/PTK2/EPHX2/COX6C/HRAS/GSTA4/COX6A1/SLC25A5/COX7C/UQCR10/SOD1/NDUFV1/GSTM3/NDUFA10/MAPK1/PTPRJ/COX7A1/NDUFA6/COX7A2/NDUFB1/MT-CO2/MAPK13/SOS2/BAD/FOXO3/PIK3R3/PRKD3/NDUFV3/MT-ND4L/NDUFA3/AKT3/IKBKG	1.01098846257452
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	7/1390	32/9376	1.47553956834532	ACSS1/LDHB/ECHS1/PCCB/HIBCH/ACACA/ACADS	1.12414832809569
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	22/1390	122/9376	1.21636985493572	PAK6/PPP2R2B/HRAS/DLG1/PPP2R3B/CD4/CDK4/VAV3/MAPK1/CD28/PPP2R5C/MAPK13/SOS2/NCK2/PIK3R3/PPP2R5E/PAK4/NFATC2/PPP3R1/AKT3/PPP2R3A/IKBKG	1.00355298501518
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	19/1390	104/9376	1.23231876037631	CDS1/PLPP3/PCYT2/LPCAT3/PISD/LPGAT1/CHPT1/GPD1L/DGKZ/GPAM/DGKD/LCAT/PLD4/PTDSS2/PLA2G12A/PLA2G4A/SAMD8/MBOAT2/PLB1	0.993899850451322
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	9/1390	44/9376	1.37972531066056	TUSC3/FUT8/RPN2/DDOST/ALG14/MAN1C1/STT3A/KRTCAP2/B4GALT2	1.05326318555397
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	16/1390	86/9376	1.25494395181529	EGFR/ERBB3/PAK6/PTK2/CAMK2G/HRAS/GAB1/PRKCB/ERBB2/MAPK1/SOS2/BAD/NCK2/PIK3R3/PAK4/AKT3	0.990864952511433
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	13/1390	68/9376	1.28954718578079	CCND1/CCNA2/HRAS/RUNX1/MAPK1/TCF7/SOS2/BAD/CSF1R/PIK3R3/JUP/AKT3/IKBKG	0.99970992248427
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	46/1390	275/9376	1.12830869849575	LAMC1/MT-ND3/MT-ND6/SLC25A4/UQCRQ/TUBB/COX6C/TUBA1B/COX6A1/CREB5/PSMD1/SLC25A5/PSMB5/COX7C/TUBB4B/UQCR10/PSMD7/PSMD14/HSPA5/SOD1/CAV2/TUBA1C/NDUFV1/NDUFA10/PSMC3/MAPK1/COX7A1/NDUFA6/COX7A2/NDUFB1/MT-CO2/MAPK13/PSMA8/BAD/C1QB/PSMD11/PIK3R3/GRIN2C/C1QA/CAV1/NDUFV3/MT-ND4L/PPP3R1/NDUFA3/PSMB6/PSMA3	0.90096158670732
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	7/1390	33/9376	1.43082624809244	DHTKD1/IDH1/IDH2/BCAT2/GOT2/ACO1/GOT1	1.03429478690213
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	26/1390	149/9376	1.17703635749119	EGFR/PLPP3/GNAS/HRAS/RRAS2/GAB1/PDGFA/LPAR6/CYTH4/ADCY6/ADCY2/PIP5K1B/CYTH3/PIK3R5/PDGFD/GNA12/DGKZ/MAPK1/ADCY7/SOS2/RALGDS/DGKD/INSR/PIK3R3/PLA2G4A/AKT3	0.908769462035407
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	20/1390	112/9376	1.20452209660843	LAMB1/LAMA5/LAMC1/ITGA6/ITGB1/GNAI1/LY96/CIITA/LAMB4/LAMC2/PIK3R5/MAPK1/LAMB2/TAB2/LAMA1/MAPK13/BAD/IRAK4/AKT3/IKBKG	0.908402581404376
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	10/1390	51/9376	1.3226124982367	ATP6V1C2/TJP1/ATP6V1B1/GNAS/PDIA4/ATP6V0A4/ATP6V0A1/ATP6V1C1/TJP2/ATP6V0E2	0.963762982810541
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	22/1390	125/9376	1.18717697841727	GNAI1/DEGS1/RAC3/PPP2R2B/HRAS/PRKCZ/PRKCB/SPTLC3/PPP2R3B/S1PR2/ORMDL3/GNA12/ORMDL1/MAPK1/SMPD1/PPP2R5C/GNAQ/MAPK13/PIK3R3/PPP2R5E/AKT3/PPP2R3A	0.878904086284322
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/1390	28/9376	1.44542651593011	GGH/DHFR/MOCS1/AKR1B1/MOCS2/PTS	0.984745751773728
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	9/1390	46/9376	1.31973725367532	PSMD1/PSMB5/PSMD7/PSMD14/PSMC3/PSMA8/PSMD11/PSMB6/PSMA3	0.906900663666849
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13/1390	71/9376	1.23505927652244	EGFR/MET/JAM3/ATP6V1C2/TJP1/ATP6V1B1/ATP6V0A4/ATP6V0A1/ADAM10/MAPK13/ATP6V1C1/ATP6V0E2/IKBKG	0.829424321431881
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	13/1390	71/9376	1.23505927652244	EGFR/MET/SLC2A1/LDHB/FGFR2/HRAS/IDH1/SLC1A5/IDH2/ERBB2/MAPK1/PIK3R3/AKT3	0.829424321431881
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/1390	23/9376	1.46637472630591	ASS1/ARG2/GOT2/GLUD2/GOT1	0.934225771230682
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	19/1390	109/9376	1.17579037687281	SLC27A2/SLC2A1/PTPRF/GFPT1/SLC27A6/PRKCZ/PRKCB/CREB5/PRKAA2/RPS6KA3/IRS1/PYGL/PRKAB2/INSR/PIK3R3/SLC27A1/TBC1D4/PCK2/AKT3	0.770135512545178
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1390	12/9376	1.6863309352518	COQ4/COQ3/GGCX	0.992480266321692
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	18/1390	103/9376	1.17879444017601	GNAS/GNAI1/PPP2R2B/GNA11/TGFBR2/TLR6/CFLAR/CALR/MAPK1/SERPINE1/GNAQ/MAPK13/C1QB/PIK3R3/C1QA/IRAK4/AKT3/IKBKG	0.761186150096797
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	26/1390	154/9376	1.13882089133888	ADRB1/GNAS/GNAI1/PPP2R2B/CAMK2G/SLC9A1/ATP2B1/CREB5/PPP2R3B/ADCY6/TPM1/ADCY2/PIK3R5/MAPK1/TNNC1/ADCY7/PPP2R5C/RPS6KA5/ATP2B4/GNAQ/MAPK13/ATP1A4/CALM2/PPP2R5E/AKT3/PPP2R3A	0.724654536714891
Organismal Systems	Nervous system	hsa04730	Long-term depression	11/1390	60/9376	1.23664268585132	IGF1R/GNAS/GNAI1/HRAS/GNA11/PRKCB/IGF1/GNA12/MAPK1/GNAQ/PLA2G4A	0.767153651437326
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1390	18/9376	1.49896083133493	CD320/MTR/MMAB/PRDX1	0.883974164257054
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/1390	24/9376	1.4052757793765	EXTL2/HS6ST2/EXT2/GLCE/XYLT1	0.829339607415965
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	7/1390	36/9376	1.31159072741807	GALNT11/GALNT18/B3GNT3/GCNT4/C1GALT1/ST3GAL1/GALNT12	0.781431156019313
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/1390	30/9376	1.34906474820144	FH/IDH1/IDH2/PC/ACO1/PCK2	0.798881044173574
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	26/1390	156/9376	1.1242206235012	EGFR/CLDN4/CCND1/CLDN7/E2F1/CDK6/PPP2R2B/HRAS/OCLN/CDK2/CLDN3/TLR3/CDK4/CFLAR/CLDN19/E2F2/RB1/MAPK1/SOS2/BAD/PIK3R3/PIAS1/YWHAE/YWHAG/AKT3/IKBKG	0.652707989636775
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	9/1390	49/9376	1.23893701365438	GALNT11/GALNT18/GXYLT1/C1GALT1/FUT10/GALNT12/XXYLT1/B4GALT2/ST6GAL1	0.699582389345398
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1390	13/9376	1.55661317100166	FEN1/PRKDC/RAD50	0.837810943034917
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	23/1390	138/9376	1.1242206235012	MT-ND3/ATP6V1C2/MT-ND6/ATP6V1B1/UQCRQ/COX6C/COX6A1/COX7C/UQCR10/NDUFV1/NDUFA10/ATP6V0A4/COX7A1/NDUFA6/ATP6V0A1/COX7A2/NDUFB1/MT-CO2/ATP6V1C1/ATP6V0E2/NDUFV3/MT-ND4L/NDUFA3	0.613299561840393
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	38/1390	235/9376	1.0907332006735	MT-ND3/MT-ND6/GNAS/UQCRQ/COX6C/HRAS/SMARCA2/COX6A1/CREB5/ADCY6/PPARG/PRKAA2/COX20/ADCY2/COX7C/UQCR10/RPS6KA3/MGLL/CPT2/NDUFV1/NDUFA10/COX7A1/NDUFAF6/ADCY7/NDUFA6/COX7A2/NDUFB1/MT-CO2/ZNF516/MAPK13/SOS2/ACTL6A/PRKAB2/ARID1A/NDUFV3/MT-ND4L/COA4/NDUFA3	0.587667526804946
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/1390	19/9376	1.42006815600151	NAGLU/GNS/ARSB/HYAL2	0.764639327951812
Organismal Systems	Immune system	hsa04611	Platelet activation	21/1390	126/9376	1.1242206235012	ITGB1/GNAS/GNAI1/PRKCZ/ADCY6/ADCY2/ARHGEF1/PIK3R5/PRKCI/MAPK1/SNAP23/ADCY7/ARHGEF12/GNAQ/MAPK13/PTGS1/COL1A1/PIK3R3/COL1A2/PLA2G4A/AKT3	0.585647773260728
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	18/1390	107/9376	1.13472735830028	SLC2A1/GNAS/LDHB/CAMK2G/CREB5/PRKAA2/ADCY2/EP300/PYGL/CREBBP/ACACA/GNAQ/PRKAB2/CALM2/PPP3R1/PCK2/AKT3/SIRT1	0.584735723920264
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	17/1390	101/9376	1.13535152076359	COL4A2/COL4A1/CCND1/HRAS/PRKCZ/PRKCB/FN1/CDK4/TGFBR2/MAPK1/SERPINE1/MAPK13/COL1A1/PIK3R3/PLCE1/COL1A2/AKT3	0.57055202731327
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	75/1390	480/9376	1.05395683453237	GPX8/MT-ND3/LRP5/APP/MT-ND6/SLC25A4/FZD6/UQCRQ/TUBB/FZD3/CAMK2G/COX6C/HRAS/TUBA1B/RPS27A/WNT4/PRKCB/GPR37/COX6A1/FZD10/FUS/PSMD1/TRAP1/TOMM40/FZD5/SLC25A5/AXIN2/PSMB5/COX7C/TUBB4B/UQCR10/PSMD7/DNAH14/PSMD14/LRP6/HSPA5/SOD1/TUBA1C/NDUFV1/C9orf72/DVL3/NDUFA10/PSMC3/MAPK1/SIGMAR1/BDNF/PSEN1/COX7A1/NDUFA6/COX7A2/NDUFB1/MT-CO2/GNAQ/MAPK13/PSMA8/BAD/UBA7/CALM2/FZD2/GPX7/PSMD11/ATXN1/WNT3/GRIN2C/CSNK1E/FZD8/NDUFV3/MT-ND4L/SPG11/PPP3R1/NDUFA3/PSMB6/PSMA3/CHRM3/UBE2J1	0.506288520179511
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	11/1390	63/9376	1.17775493890602	PTGES/HPGD/EPHX2/LTA4H/CBR3/CYP2J2/PTGR1/PTGS1/PLA2G12A/PLA2G4A/PLB1	0.590575647867276
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1390	38/9376	1.24255963650133	PRKCB/IGF1/IRS1/MAPK1/ATP1A4/INSR/PIK3R3	0.625045714728978
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1390	14/9376	1.44542651593011	FUT8/ST3GAL1/B4GALT2	0.695799562848662
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	28/1390	174/9376	1.08545439510461	TUSC3/LMAN1/HSP90B1/RRBP1/BAG2/P4HB/RPN2/WFS1/HSPA4L/SVIP/PDIA6/UBE4B/DDOST/HSP90AA1/GANAB/HSPA5/PDIA4/CALR/HSP90AB1/MAN1C1/UBXN2A/STT3A/UGGT2/SIL1/ERLEC1/KRTCAP2/PDIA3/UBE2J1	0.474674934798701
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	17/1390	103/9376	1.11330586016624	COL14A1/COL4A2/DPP4/MME/COL4A1/COL21A1/KCNN4/COL5A2/KCNK5/KCNE3/SLC1A5/PRCP/COL8A1/ATP1A4/COL1A1/COL1A2/COL6A1	0.482379940888751
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	12/1390	71/9376	1.14005471678995	CCND1/PRLR/HRAS/SOCS2/ELF5/MAPK1/MAPK13/SOS2/SOCS7/FOXO3/PIK3R3/AKT3	0.494193593017995
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	24/1390	149/9376	1.08649509922264	MT-ND3/GABRE/MT-ND6/GNG12/GNAI1/GABRA4/PRKCB/ADCY6/ADCY2/MGLL/NDUFV1/NDUFA10/GNG2/MAPK1/ADCY7/NDUFA6/NDUFB1/GNAQ/MAPK13/DAGLB/NDUFV3/MT-ND4L/NDUFA3/GNG7	0.443999785711621
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	22/1390	137/9376	1.08319067373838	CTSV/CTSL/BIRC5/PARP1/HRAS/TUBA1B/PARP2/LMNB2/CTSF/PIDD1/CFLAR/TUBA1C/LMNA/DFFA/MAPK1/PMAIP1/CASP2/BAD/PIK3R3/GADD45A/AKT3/IKBKG	0.409214323774884
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1390	53/9376	1.14543233337858	GNAS/ATP2B1/CLTC/PRKCB/ADCY6/ATP2B4/GNAQ/ATP1A4/AP2A2	0.442944639533901
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	34/1390	217/9376	1.05687100089514	EGFR/ADRB1/CDC6/BIRC5/CCND1/HSP90B1/KLF5/MGST3/E2F1/GNAS/GNAI1/EPHX2/HRAS/CDC25A/GSTA4/NOTCH2/PRKCB/HSP90AA1/CREB5/ADCY6/ADCY2/RPS6KA3/GSTM3/HSP90AB1/RB1/MAPK1/ADCY7/SOS2/BAD/JAG1/PIK3R3/FGF2/PAQR7/AKT3	0.353610452868456
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/1390	34/9376	1.19035124841303	POLR2L/POLR2I/POLR3K/POLR2H/POLR2D/POLR3B	0.463877856730486
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	14/1390	86/9376	1.09807595783838	SLC2A1/KCNN4/GNAS/CAMK2G/PCLO/GNA11/PRKCB/CREB5/ADCY6/ADCY2/ADCY7/GNAQ/ATP1A4/CHRM3	0.3811819367123
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	12/1390	73/9376	1.10882034098748	MLLT1/PSIP1/CD4/EP300/NELFCD/PPIA/CREBBP/FEZ1/ELL2/PDCD6IP/RAN/CPSF6	0.389393221763424
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/1390	28/9376	1.20452209660843	B3GNT3/A4GALT/GCNT2/ST3GAL4/B4GALT2	0.452155986624301
Organismal Systems	Digestive system	hsa04970	Salivary secretion	15/1390	93/9376	1.08795544209793	ADRB1/KCNN4/GNAS/TRPV6/SLC9A1/ATP2B1/PRKCB/ADCY6/ADCY2/ADCY7/ATP2B4/GNAQ/ATP1A4/CALM2/CHRM3	0.355621820056322
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	11/1390	67/9376	1.10744121121014	CAMK2G/HRAS/PRKCB/RPS6KA3/EP300/MAPK1/CREBBP/GNAQ/CALM2/GRIN2C/PPP3R1	0.368201172543212
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1390	61/9376	1.10579077721429	SLC40A1/TRPV6/SLC34A2/ATP7B/ATP2B1/SLC46A1/ATP2B4/ATP1A4/ATP7A/CYBRD1	0.345819661269196
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1390	16/9376	1.26474820143885	MIF/GOT2/GOT1	0.442164092013189
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1390	16/9376	1.26474820143885	A4GALT/ST3GAL1/GBGT1	0.442164092013189
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	56/1390	368/9376	1.02646230841414	GPX8/MT-ND3/MT-ND6/PFN2/UQCRQ/TUBB/COX6C/TUBA1B/COX6A1/FUS/PSMD1/TOMM40/PSMB5/COX7C/TUBB4B/UQCR10/PSMD7/DNAH14/PSMD14/HSPA5/SOD1/SETX/TUBA1C/NDUFV1/NUP155/C9orf72/NDUFA10/PSMC3/NXT1/NDC1/SIGMAR1/COX7A1/NDUFA6/COX7A2/NDUFB1/MT-CO2/MAPK13/PSMA8/BAD/NUP160/GPX7/HNRNPA3/NUP50/PSMD11/GRIN2C/NUP37/NUP35/NUP205/NDUFV3/MT-ND4L/NUP107/SPG11/PPP3R1/NDUFA3/PSMB6/PSMA3	0.216055751915514
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	18/1390	115/9376	1.05578980294026	GNG12/GNAI1/CAMK2G/HRAS/GNA11/PRKCB/CREB5/ADCY6/ADCY2/PIK3R5/GNG2/MAPK1/ADCY7/GNAQ/PIK3R3/GNG7/AKT3/CHRM3	0.251132656619899
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/1390	23/9376	1.17309978104473	B4GAT1/B3GALNT2/CHST10/B4GALT2	0.346747512943702
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1390	23/9376	1.17309978104473	MME/ENPEP/PRCP/ATP6AP2	0.346747512943702
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1390	23/9376	1.17309978104473	SLC25A10/GLUD2/ATP1A4/PCK2	0.346747512943702
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	9/1390	56/9376	1.08406988694758	LRP2/CCND1/GLI3/GAS1/SPOPL/PTCH1/EVC2/CSNK1E/BTRC	0.263241832950387
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/1390	76/9376	1.06505111700114	GNAS/GNAI1/CAMK2G/SLC9A1/PRKCB/ADCY6/ADCY2/ADCY7/GNAQ/ATP1A4/CALM2/CHRM3	0.237546406809011
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	16/1390	103/9376	1.04781728015646	MSI2/PPP2R2B/PPP2R3B/FUS/MAGOHB/PCF11/NXT1/PPP2R5C/UPF3A/PPP2R5E/CPSF6/RNMT/CSTF3/UPF1/CPSF4/PPP2R3A	0.203573731680705
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	5/1390	30/9376	1.1242206235012	PGAP2/PGAP1/GPAA1/PIGU/PIGO	0.284295397692987
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/1390	70/9376	1.05997944501542	DAG1/CCND1/DMD/SGCE/RAC3/SGCB/SSPN/CD28/LAMA1/EIF4G3/CAV1	0.210134966089888
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	18/1390	117/9376	1.03774211400111	SMARCA1/RBBP7/SMARCA2/MTA3/CECR2/BCL7A/MORF4L2/YEATS4/RUVBL1/EPC1/ACTR6/BRD7/ACTL6A/BAZ1B/RBBP4/ARID1A/HDAC2/RUVBL2	0.171382114301246
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1390	17/9376	1.19035124841303	MTR/TXNRD3/PAPSS2	0.327713137505725
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	15/1390	97/9376	1.04309130015575	GNG12/GNAS/GNAI1/CAMK2G/PRKCB/ADCY6/ADCY2/GNG2/MAPK1/ADCY7/RPS6KA5/GNAQ/CALM2/GRIN2C/GNG7	0.177972648334906
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	15/1390	98/9376	1.03244751137865	GNAS/CAMK2G/GNA11/ATP2B1/PRKCB/CREB5/ADCY6/ADCY2/ADCY7/ATP2B4/GNAQ/ATP1A4/CALM2/DAGLB/PRKD3	0.13470869613443
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	25/1390	166/9376	1.01586200918783	ADRB1/SLC25A4/GNAI1/GNA11/ATP2B1/CREB5/ADCY6/SLC25A5/ADCY2/PIK3R5/IRS1/GNA12/MEF2C/MAPK1/ADCY7/ADRA2C/ATP2B4/GNAQ/ATP1A4/BAD/CALM2/INSR/NFATC2/PPP3R1/AKT3	0.0860222527009872
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	10/1390	65/9376	1.03774211400111	ALDH7A1/PLPP3/LIPG/AKR1B1/MGLL/DGKZ/GPAM/DGKD/AGK/MBOAT2	0.127383483886789
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	15/1390	99/9376	1.02201874863745	GNAS/CAMK2G/PRKCB/ADCY6/ADCY2/IGF1/TRPV4/CYP2J2/ADCY7/GNAQ/MAPK13/CALM2/PIK3R3/HRH1/PLA2G4A	0.0918829304964942
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1390	18/9376	1.1242206235012	FASN/MECR/ACACA	0.220073029678863
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/1390	52/9376	1.03774211400111	LRP2/LIPG/LIPA/LRPAP1/LDLRAP1/MYLIP/SOAT1/LCAT	0.113855796776209
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	30/1390	201/9376	1.00676473746376	MET/SPINT1/PBX1/FLT1/CCNA2/IGF1R/MLLT1/FUT8/PTK2/HPGD/ETV5/ASPSCR1/PDGFA/FUS/MYCN/PROM1/SIX4/FLI1/PPARG/TGFBR2/RUNX1/IGF1/MEF2C/AFF1/CSF1R/HDAC2/JUP/BMP2K/GADD45A/MAF	0.0404458832726442
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	14/1390	93/9376	1.01542507929141	GATA3/NOTCH3/NOTCH2/CD4/JAG2/IL12RB2/MAPK1/JAK3/MAPK13/JAG1/NFATC2/PPP3R1/MAF/IKBKG	0.0623667466308097
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1390	32/9376	1.05395683453237	AKR1B1/GALE/B4GALT2/PGM1/UGP2	0.127550869299814
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/1390	87/9376	1.00792193831142	UQCRQ/ASPH/SLC9A1/COX6C/COX6A1/TPM1/COX7C/UQCR10/TNNC1/COX7A1/COX7A2/MT-CO2/ATP1A4	0.0309695565280183
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/1390	47/9376	1.00462268483086	PRKCZ/SOCS2/IRS1/MAPK1/MAFA/INSR/PIK3R3	0.0132542162659678
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	23/1390	157/9376	0.988168446134812	UQCRQ/COX6C/COX6A1/PPARG/PRKAA2/COX7C/UQCR10/NDUFV1/IRS1/NDUFA10/COX7A1/NDUFA6/COX7A2/NDUFB1/MT-CO2/MAPK13/PRKAB2/INSR/PIK3R3/MAP3K11/NDUFV3/NDUFA3/AKT3	-0.0623703368190299
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	17/1390	116/9376	0.988538824113123	SLC38A1/GNG12/GNAS/GNAI1/HOMER1/SHANK2/PRKCB/ADCY6/ADCY2/GNG2/MAPK1/ADCY7/GNAQ/GRIN2C/PLA2G4A/PPP3R1/GNG7	-0.0518180498024943
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	20/1390	138/9376	0.977583150870608	PTPRF/SORBS1/FASN/HRAS/PRKCZ/SOCS2/PRKAA2/PRKCI/IRS1/PYGL/MAPK1/ACACA/SOS2/BAD/PRKAB2/CALM2/INSR/PIK3R3/PCK2/AKT3	-0.110676016279742
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/1390	34/9376	0.991959373677529	PRKAA2/BHLHE41/PRKAB2/CSNK1E/BTRC	-0.019594662689816
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	10/1390	69/9376	0.977583150870608	RAC3/HRAS/INPP5D/VAV3/MAPK1/MAPK13/SOS2/PIK3R3/PLA2G4A/AKT3	-0.0779691218238612
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	12/1390	83/9376	0.975227528820317	SLC27A2/PXMP2/EPHX2/ECI2/SLC25A17/IDH1/IDH2/SOD1/PRDX1/PMVK/PEX3/MVK	-0.0945711771497084
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	20/1390	139/9376	0.970550178562186	EGFR/HSP90B1/KRT18/GNAS/GNAI1/HRAS/KRT23/HSP90AA1/CREB5/ADCY6/ADCY2/HSP90AB1/MAPK1/ADCY7/GNAQ/SOS2/KRT19/CALM2/PIK3R3/AKT3	-0.145932821599379
Human Diseases	Substance dependence	hsa05032	Morphine addiction	13/1390	91/9376	0.963617677286742	GABRE/GNG12/GNAS/GNAI1/GABRA4/PRKCB/PDE10A/ADCY6/ADCY2/GNG2/ADCY7/PDE4D/GNG7	-0.145495160948267
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/1390	42/9376	0.963617677286742	ALDH7A1/AOC1/ACAT2/DHTKD1/HADH/ECHS1	-0.0985847079201415
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	22/1390	154/9376	0.963617677286742	EGFR/CCND1/GNAS/GNAI1/CAMK2G/HRAS/PRKCB/ADCY6/PRKAA2/ADCY2/PIK3R5/MEF2C/MAPK1/ADCY7/GNAQ/PRKAB2/CALM2/PPP1R12B/NFATC2/PLA2G4A/PPP3R1/TRPM2	-0.189918210120324
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/1390	21/9376	0.963617677286742	BCAT2/VNN2/PANK1	-0.0696316295114059
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	19/1390	134/9376	0.956426500590572	MYH10/CALD1/GNAS/GNA11/PRKCB/ADCY6/ADCY2/ARHGEF1/GNA12/MAPK1/PPP1R14A/ADCY7/ARHGEF12/GNAQ/CALM2/ACTA2/PPP1R12B/PLA2G12A/PLA2G4A	-0.211943568471439
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/1390	36/9376	0.936850519584333	AGL/PYGL/GYG1/PGM1/UGP2	-0.158371116792011
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	29/1390	205/9376	0.954216529215652	CCND1/CCNE1/CCNE2/CCNA2/SKP2/E2F1/CDK6/CDK2/NEDD4/ENTPD1/PSMD1/CDK4/PSMD7/PSMD14/CALR/E2F2/PSMC3/RB1/TAB2/JAK3/MAPK13/PDIA3/PSMD11/PIK3R3/HDAC2/IRAK4/GADD45A/AKT3/IKBKG	-0.276506714627566
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	46/1390	323/9376	0.960634340824554	EGFR/MET/TIMP3/CCND1/CCNE1/CCNE2/CDCA5/BRCA1/KIF23/EFNA1/STMN1/ERBB3/EZH2/CDKN2A/E2F1/ABCB1/NOTCH3/TP63/CDK6/FZD3/EFNA5/DNMT1/HRAS/CDC25A/ZEB2/SOX4/NOTCH2/PRKCB/PDGFA/TPM1/ERBB2/DNMT3A/EP300/IRS1/E2F2/CDC25C/MAPK1/RDX/CREBBP/RPS6KA5/SOS2/PIK3R3/WNT3/PAK4/HDAC2/SIRT1	-0.300366099179506
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/1390	51/9376	0.925828748765693	PLPP3/CHPT1/ENPP2/PLD4/PLA2G12A/PLA2G4A/PLB1	-0.221576990101348
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	27/1390	193/9376	0.943646326462146	PARD3/GNG12/BCAR1/PTK2/GNAI1/RAC3/HRAS/PRKCZ/PRKCB/ADCY6/ADCY2/VAV3/PIK3R5/CX3CR1/GNG2/MAPK1/ADCY7/JAK3/TIAM1/GNAQ/SOS2/BAD/FOXO3/PIK3R3/GNG7/AKT3/IKBKG	-0.330017507182141
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	20/1390	144/9376	0.936850519584333	SLC25A4/PRKCB/PSMD1/SLC25A5/PSMB5/PSMD7/NOP56/VLDLR/PSMD14/AFG3L2/PSMC3/GNAQ/PSMA8/PSMD11/ATXN1/PIK3R3/GRIN2C/PSMB6/PSMA3/AKT3	-0.318589541677573
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	16/1390	116/9376	0.930389481518234	CLDN4/JAM3/CLDN7/ITGB1/BCAR1/PTK2/GNAI1/OCLN/PRKCB/CLDN3/VAV3/CLDN19/ARHGAP5/CTNND1/MAPK13/PIK3R3	-0.314721748367532
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	14/1390	102/9376	0.925828748765693	GNAS/SLC9A1/ATP2B1/PRKCB/ADCY6/ADCY2/ADCY7/ATP2B4/GNAQ/ATP1A4/CLCA2/RAB27B/PLA2G12A/CHRM3	-0.314217617197069
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/1390	30/9376	0.899376498800959	CYP2J2/PLA2G12A/PLA2G4A/PLB1	-0.230290248787601
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1390	45/9376	0.899376498800959	ABCB1/ABCA5/ABCB8/ABCA6/ABCG2/ABCA12	-0.28227341152536
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/1390	38/9376	0.887542597500946	UNG/CIITA/CD4/JAK3/IKBKG	-0.289788600178749
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	11/1390	82/9376	0.904860501842428	CTSL/HSPA2/HSP90AA1/LGMN/CIITA/CD4/HSPA5/CALR/HSP90AB1/NFYB/PDIA3	-0.360989719356837
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1390	31/9376	0.870364353678348	ALDH7A1/ECHS1/HIBCH/ACADS	-0.301608805555102
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/1390	31/9376	0.870364353678348	HSPA5/IMMP1L/IMMP2L/SRPRB	-0.301608805555102
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	21/1390	155/9376	0.913882571362265	COLEC12/CTSL/ATP6V1C2/ITGB5/ATP6V1B1/ITGB1/TUBB/TFRC/PLA2R1/TUBA1B/ITGAV/MRC1/TUBB4B/TLR6/TUBA1C/CALR/MSR1/ATP6V0A4/ATP6V0A1/ATP6V1C1/ATP6V0E2	-0.451020495037154
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	14/1390	105/9376	0.899376498800959	E2F1/HRAS/RRAS2/RPS27A/SIAH1/TOMM40/MTX2/BNIP3/MUL1/ATG9B/FOXO3/RHOT1/ATG9A/NBR1	-0.432572761393001
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/1390	69/9376	0.879824835783547	GNAS/CAMK2G/PRKCB/CREB5/CALM2/GRIN2C/HDAC2/PPP3R1/SIRT1	-0.417987022391547
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/1390	91/9376	0.889493240572377	RAC3/HRAS/INPP5D/PRKCB/VAV3/MAPK1/SOS2/PIK3R3/NFATC2/PPP3R1/AKT3/IKBKG	-0.441923372389152
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	34/1390	248/9376	0.924762125783244	HSP90B1/PFN2/TUBB/NCKAP1/MYO6/DYNLL2/HRAS/TUBA1B/LY96/HSP90AA1/ARPC5L/CYTH4/TLR5/TUBB4B/TLR6/CYTH3/CSE1L/TUBA1C/HSP90AB1/MAPK1/TCF7/CYFIP2/TAB2/ACTR3C/PLEKHM2/FBXO22/PIK3C2B/MAPK13/DYNC2LI1/RPS3/IRAK4/WASL/AKT3/IKBKG	-0.500959857262192
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/1390	78/9376	0.864785095000922	ITGB1/GNAI1/LY96/MAPK1/C4BPB/MAPK13/CALM2/C1QB/C1QA/IRAK4	-0.500271178549168
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1390	17/9376	0.793567498942023	CDO1/GGT7	-0.355398996165613
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1390	17/9376	0.793567498942023	CA8/GLUD2	-0.355398996165613
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	19/1390	144/9376	0.890007993605116	CCND1/ALDH7A1/FASN/LY96/ADH5/PRKAA2/TCF7/TAB2/ACADVL/ACACA/MAPK13/FOXO3/PRKAB2/C1QB/C1QA/IRAK4/AKT3/SIRT1/IKBKG	-0.554910391580178
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	10/1390	79/9376	0.853838448228759	SLC6A4/ATP6V1C2/ATP6V1B1/CLTC/SYT1/ATP6V0A4/ATP6V0A1/ATP6V1C1/ATP6V0E2/AP2A2	-0.544256545467185
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	26/1390	196/9376	0.894787843194832	CCND1/GNG12/E2F1/IL6ST/CDK6/HRAS/RPS27A/TLR3/CDK4/PIK3R5/EP300/E2F2/GNG2/RB1/MAPK1/TCF7/CREBBP/MAPK13/CALM2/PIK3R3/NFATC2/FGF2/PPP3R1/GNG7/AKT3/IKBKG	-0.621013446755629
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1390	26/9376	0.77830658550083	PLA2G12A/PLA2G4A/PLB1	-0.472239212884558
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	3/1390	26/9376	0.77830658550083	MNX1/MAFA/RFX6	-0.472239212884558
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/1390	42/9376	0.803014731072285	SLC40A1/GCLM/TFRC/LPCAT3/STEAP3	-0.533768428004534
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/1390	65/9376	0.830193691200885	PBX1/GNAS/GNA11/CREB5/ADCY6/ADCY2/ADCY7/GNAQ	-0.573113609909417
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	8/1390	65/9376	0.830193691200885	KCNN4/HRAS/GNA11/PRKCB/MAPK1/GNAQ/PIK3R3/AKT3	-0.573113609909417
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	30/1390	226/9376	0.895396956770867	ADRB1/GLI3/GNAS/GNAI1/RAC3/CAMK2G/SLC9A1/RRAS2/ATP2B1/PDE10A/CREB5/ADCY6/ADCY2/VAV3/EP300/MAPK1/BDNF/CREBBP/ADCY7/TIAM1/PTCH1/PDE4D/ATP2B4/ATP1A4/BAD/CALM2/PIK3R3/PLCE1/GRIN2C/AKT3	-0.664073848124884
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	17/1390	133/9376	0.862184237572348	GNG12/GNAS/GNAI1/PPP2R2B/CAMK2G/PRKCB/CREB5/PPP2R3B/GNG2/PPP2R5C/GNAQ/MAPK13/CALM2/PPP2R5E/GNG7/AKT3/PPP2R3A	-0.667800317835748
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/1390	35/9376	0.770894141829394	ENOSF1/AKR1B1/PMM1/PMM2	-0.566502610725673
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1390	43/9376	0.784339969884557	PLPP3/ACAT2/GOT2/SLC27A1/PLA2G12A	-0.591318738596445
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	11/1390	89/9376	0.833691698326732	SLC38A1/GABRE/GNG12/GNAI1/GABRA4/PRKCB/ADCY6/ADCY2/GNG2/ADCY7/GNG7	-0.657657223371066
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/1390	90/9376	0.824428457234213	EGFR/HRAS/CD4/MAPK1/CD28/MAPK13/PIK3R3/NFATC2/PPP3R1/AKT3/IKBKG	-0.698215403718852
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1390	10/9376	0.674532374100719	PAPSS2	-0.429594887876371
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/1390	44/9376	0.76651406147809	GNAS/DYNLL2/CREB5/ADCY6/DYNC2LI1	-0.647631686604832
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1390	36/9376	0.749480415667466	DCXR/AKR1B1/UGP2/XYLB	-0.628272253197672
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	12/1390	98/9376	0.825958009102922	CDS1/INPP5D/PRKCB/PIP5K1B/DGKZ/MTMR6/PIK3C2B/DGKD/CALM2/PPIP5K2/PIK3R3/PLCE1	-0.722550626234175
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/1390	76/9376	0.798788337750852	SLC27A2/SORBS1/SLC27A6/ACADL/PPARG/DBI/CPT2/SLC27A1/PCK2	-0.734762285089106
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1390	20/9376	0.674532374100719	CYB5R1/UGP2	-0.607863508821663
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/1390	37/9376	0.729224188216994	ADH5/MIF/GOT2/GOT1	-0.688476191382357
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	33/1390	254/9376	0.876360958477313	EGFR/MET/ADRB1/FLT1/MCOLN3/SLC25A4/ERBB3/GNAS/FGFR2/ASPH/CAMK2G/GNA11/ATP2B1/PRKCB/PDGFA/SLC25A5/ADCY2/ERBB2/CYSLTR1/PDGFD/TNNC1/ADCY7/ATP2B4/GNAQ/FGF1/CALM2/PLCE1/HRH1/GRIN2C/NFATC2/FGF2/PPP3R1/CHRM3	-0.833404496727696
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/1390	69/9376	0.782066520696486	ADRB1/GNAS/GNAI1/ADCY6/GNAQ/CLCA2/CALM2/PPP3R1	-0.758004922959233
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	14/1390	115/9376	0.821169846731311	SLC6A4/APP/GNG12/GNAS/GNAI1/HRAS/PRKCB/GNG2/MAPK1/CYP2J2/GNAQ/PTGS1/PLA2G4A/GNG7	-0.804987454825792
NA	NA	hsa04081	Hormone signaling	28/1390	219/9376	0.862415820768043	ADRB1/SLC40A1/GNG12/SLC16A2/IGF1R/GNAS/PRLR/GNAI1/IGF2/BMPR1A/GNA11/ITGAV/ADCY6/CSH2/ADCY2/GHR/IGF1/THRB/IRS1/GNA12/GNG2/SMAD5/ADCY7/ADRA2C/GNAQ/INSR/PIK3R3/GNG7	-0.85949297841096
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	21/1390	168/9376	0.843165467625899	EGFR/CCND1/IL6ST/PRLR/HRAS/LIFR/PDGFA/SOCS2/CSH2/GHR/EP300/IL12RB2/CSF3R/CREBBP/JAK3/SOS2/SOCS7/CSF2RA/PIK3R3/PIAS1/AKT3	-0.855740456221806
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	13/1390	109/9376	0.804488152597188	GATA3/IL6ST/HSP90AA1/CD4/TGFBR2/RUNX1/HSP90AB1/MAPK1/JAK3/MAPK13/NFATC2/PPP3R1/IKBKG	-0.856535036142272
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/1390	55/9376	0.735853499018967	PLPP3/DEGS1/SPTLC3/SMPD1/SMPD4/SAMD8	-0.819640365540105
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1390	12/9376	0.562110311750599	CD46	-0.633217668170304
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	27/1390	216/9376	0.843165467625899	HSP90B1/PTK2/CAMK2G/HRAS/HSPD1/HSPA2/LY96/HSP90AA1/PPARG/VAV3/VLDLR/TLR6/ARHGEF1/HSPA5/HSP90AB1/MAPK1/CYP2J2/TAB2/MAPK13/BAD/CALM2/PIK3R3/NFATC2/IRAK4/PPP3R1/AKT3/IKBKG	-0.972857468994255
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1390	22/9376	0.613211249182472	ALDH7A1/AOC1	-0.757730690305676
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/1390	48/9376	0.702637889688249	PRKCB/SLC37A4/ATP1A4/PIK3R3/AKT3	-0.861668795281387
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/1390	88/9376	0.76651406147809	F5/SERPINE2/CD59/CD46/C4BPB/SERPINE1/C1QB/F13A1/A2M/C1QA	-0.918056370999781
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1390	49/9376	0.688298340919101	GNAS/GNAI1/CREB5/BDNF/GRIN2C	-0.912629600946467
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	12/1390	105/9376	0.770894141829394	PARP1/PPP1R13L/LY96/PRKCB/EDARADD/PIDD1/CFLAR/LTBR/TAB2/IRAK4/GADD45A/IKBKG	-0.984908620145661
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	12/1390	105/9376	0.770894141829394	HRAS/RRAS2/MAPK1/ARHGEF12/EGR2/MAPK13/CALM2/PIK3R3/NFATC2/PPP3R1/AKT3/IKBKG	-0.984908620145661
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	12/1390	109/9376	0.742604448551251	LY96/TLR1/TLR3/TLR5/TLR6/MAPK1/TAB2/MAPK13/PIK3R3/IRAK4/AKT3/IKBKG	-1.12764679425685
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/1390	94/9376	0.717587632022042	HSP90B1/TRAF4/HSP90AA1/HSP90AB1/MAPK4/IL17RB/MAPK1/TAB2/MAPK13/IKBKG	-1.14803530113065
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	4/1390	44/9376	0.613211249182472	CDK7/TAF4B/MNAT1/TAF6	-1.07285540464453
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1390	15/9376	0.44968824940048	ST3GAL1	-0.889859986180833
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1390	15/9376	0.44968824940048	AK5	-0.889859986180833
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/1390	70/9376	0.674532374100719	SLC2A1/PRKAA2/IRS1/PRKAB2/PCK2/AKT3/IKBKG	-1.14025944244938
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	10/1390	95/9376	0.710034078000757	CTSL/FLT1/ATP6V1C2/ATP6V1B1/ANGPT1/ATP6V0A4/CD28/ATP6V0A1/ATP6V1C1/ATP6V0E2	-1.18505842588827
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/1390	119/9376	0.73688410616045	RHBDF1/CREB5/RHBDF2/CFLAR/MAPK1/TAB2/RPS6KA5/MAPK13/JAG1/PIK3R3/MMP14/AKT3/IKBKG	-1.20507427953718
Human Diseases	Infectious disease: viral	hsa05162	Measles	15/1390	136/9376	0.743969530258146	CCND1/CCNE1/CCNE2/CDK6/CDK2/CD46/CDK4/CD28/TAB2/JAK3/BAD/PIK3R3/IRAK4/AKT3/IKBKG	-1.2547393177455
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	30/1390	253/9376	0.799840759803225	EGFR/ITGB1/FNBP1L/BCAR1/PFN2/PTK2/FOXO4/DOCK1/RPS27A/ARPC5L/CTTN/CYTH4/TLR5/WASF1/CYTH3/BNIP3/MAPK1/TAB2/ACTR3C/RPS6KA5/MAPK13/FOXO3/PIK3R3/PLCE1/WASF2/FOXO6/BTRC/WASL/AKT3/IKBKG	-1.34646618892286
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	19/1390	169/9376	0.758350006385424	CTSL/IGF1R/HRAS/RRAS2/RPS27A/HMGB1/PRKAA2/CFLAR/C9orf72/IRS1/BNIP3/MAPK1/ATG9B/BAD/ATG9A/PIK3R3/NBR1/VMP1/AKT3	-1.32251149075261
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/1390	90/9376	0.674532374100719	SLC2A1/GNAS/ABCB1/SLC9A1/ADCY6/ADCY2/ADCY7/ATP1A4/ABCG2	-1.29432427507816
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/1390	38/9376	0.532525558500568	QPRT/PNP/SIRT1	-1.20462291508647
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	10/1390	100/9376	0.674532374100719	MME/ITGA6/CD24/CD59/TFRC/ITGA3/CD4/CSF3R/CSF1R/CSF2RA	-1.36507279460191
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	20/1390	181/9376	0.745339639890298	CAMK2G/HSPD1/PLA2R1/TLR1/MRC1/CIITA/TLR6/EP300/ATP6V0A4/MAPK1/CREBBP/ARHGEF12/NFYB/ATP6V0A1/MAPK13/BAD/CALM2/IRAK4/PPP3R1/AKT3	-1.44328851229409
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/1390	18/9376	0.374740207833733	FUCA1	-1.10772923947752
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/1390	67/9376	0.604058842478256	ACSS1/ALDH7A1/LDHB/ADH5/PGM1/PCK2	-1.35689086911437
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1390	41/9376	0.493560273732234	GABRE/GABRA4/GRIN2C	-1.35578529125856
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/1390	78/9376	0.605349566500646	ISYNA1/INPP5D/PIP5K1B/MTMR6/PIK3C2B/PPIP5K2/PLCE1	-1.46013664309426
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	7/1390	78/9376	0.605349566500646	BTG3/HSPD1/EXOSC8/LSM2/LSM3/DIS3L/LSM5	-1.46013664309426
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/1390	31/9376	0.435182176839174	RPIA/PGM1	-1.31409865907628
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1390	79/9376	0.597686913760131	MGST3/GSTA4/GSTP1/ADH5/GSTM3/CBR3/AKR7A2	-1.49807885767285
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/1390	32/9376	0.42158273381295	ATG9B/ATG9A	-1.36734531889401
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/1390	32/9376	0.42158273381295	BIRC5/PMAIP1	-1.36734531889401
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/1390	33/9376	0.408807499454981	SNAP23/BNIP1	-1.41928985078495
NA	NA	hsa04082	Neuroactive ligand signaling	21/1390	199/9376	0.711818083221865	ADRB1/SLC6A4/GABRE/GNG12/GNAS/GNAI1/GNA11/GABRA4/PRKCB/GLRB/ADCY6/ADCY2/OGFRL1/GNG2/ADCY7/ADRA2C/GNAQ/HRH1/GRIN2C/GNG7/CHRM3	-1.71423865284011
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/1390	46/9376	0.439912417891774	ALAD/MMAB/HMBS	-1.58862876967507
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	17/1390	173/9376	0.662835280908221	SLC25A4/CDK6/PRKCB/FDPS/CIITA/SLC25A5/TLR3/CDK4/EP300/NXT1/MAPK1/CREBBP/PIK3R3/IRAK4/CPSF4/AKT3/IKBKG	-1.86736343120483
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/1390	37/9376	0.364612094108497	PRKCB/GNAQ	-1.61554107295653
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/1390	78/9376	0.518871057000553	ITGB1/PRKCB/MAPK1/TAB2/MAPK13/IRAK4	-1.78009179794262
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	16/1390	168/9376	0.642411784857828	SLC25A4/PARP1/CAMK2G/CHMP4C/HMGB1/HSP90AA1/SLC25A5/TLR3/CFLAR/HSP90AB1/PPIA/PYGL/SMPD1/JAK3/GLUD2/PLA2G4A	-1.95111814810905
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/1390	50/9376	0.404719424460432	MET/GYPC/SDC1	-1.76070822670436
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1390	73/9376	0.462008475411452	MGST3/GSTA4/GSTP1/ADH5/GSTM3	-1.92510197211241
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/1390	83/9376	0.487613764410159	POLR2L/POLR3K/POLR2H/G3BP1/POLR3B/IKBKG	-1.95608137369764
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1390	29/9376	0.232597370379558	CALM2	-1.72669068469043
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/1390	66/9376	0.408807499454981	GATA3/TLR5/IL12RB2/MAF	-2.01073310811559
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	12/1390	142/9376	0.570027358394974	FHL2/PPARG/TGFBR2/MAPK1/TAB2/MAPK13/CSF1R/PIK3R3/NFATC2/PPP3R1/AKT3/IKBKG	-2.15386483365459
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/1390	44/9376	0.306605624591236	HSPD1/CD28	-1.92330284072393
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/1390	56/9376	0.361356628982528	HSPD1/TLR5/BNIP3	-1.99973685813412
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1390	31/9376	0.217591088419587	ALDH7A1	-1.82034358583686
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1390	68/9376	0.396783749471011	ALDH1A3/ADH5/RDH10/RDH13	-2.08270465289254
Human Diseases	Immune disease	hsa05310	Asthma	1/1390	32/9376	0.210791366906475	PRG2	-1.86564404829195
Human Diseases	Substance dependence	hsa05034	Alcoholism	17/1390	191/9376	0.600369128780745	GNG12/SLC29A1/GNAS/GNAI1/HRAS/SLC29A2/CREB5/PKIA/HAT1/GNG2/MAPK1/BDNF/SOS2/CALM2/GRIN2C/HDAC2/GNG7	-2.32790106236146
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1390	70/9376	0.385447070914697	MGST3/GSTA4/GSTP1/GSTM3	-2.15305524885383
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/1390	50/9376	0.269812949640288	LTBR/CD28	-2.15973172891793
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/1390	86/9376	0.392169984942279	GABRA4/ADCY6/KCNK5/SCN9A/CHRM3	-2.3623916343838
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/1390	99/9376	0.408807499454981	KRT18/KRT23/FPR2/KRT19/C1QB/C1QA	-2.46701119723161
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/1390	66/9376	0.306605624591236	HSD17B1/STS/DHRS11	-2.35833679610312
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/1390	39/9376	0.172957019000184	CD28	-2.15916131104692
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	9/1390	133/9376	0.456450478714773	RAC3/HRAS/PRKCB/VAV3/MAPK1/SOS2/PIK3R3/NFATC2/PPP3R1	-2.63382458348548
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	14/1390	183/9376	0.516035696033337	POP7/REXO2/NOP56/RCL1/NXT1/TCOF1/NHP2/NVL/WDR43/RAN/EMG1/RPP30/GNL3/NOP58	-2.75828177903035
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/1390	72/9376	0.2810551558753	MAP3K1/MAPK13/IKBKG	-2.5547908748922
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/1390	45/9376	0.149896083133493	CD28	-2.38474839282642
Genetic Information Processing	Transcription	hsa03040	Spliceosome	20/1390	243/9376	0.555170678272197	FUS/MAGOHB/SNRPG/PRPF40B/SNRPA1/LSM2/PPIL1/USP39/SF3B1/LSM3/HNRNPA3/SNRPD1/THOC3/SF1/PRPF19/LSM5/SNRPF/PPIH/SRSF10/TCERG1	-2.93101607422824
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/1390	54/9376	0.124913402611244	CD28	-2.6904303181934
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/1390	100/9376	0.269812949640288	IL6ST/CX3CR1/LTBR/CSF1R	-3.06254262513077
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	12/1390	187/9376	0.432854999422922	HSP90AA1/NLRP1/CARD8/HSP90AB1/MAPK1/TAB2/TRIP6/MAPK13/YWHAE/IRAK4/IKBKG/TRPM2	-3.26820410389141
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	10/1390	180/9376	0.374740207833733	SRPK1/TLR3/CALR/TAB2/BAD/PDIA3/PIK3R3/IRAK4/AKT3/IKBKG	-3.53366730769263
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	22/1390	298/9376	0.497976920477041	BMP7/IL6ST/PRLR/BMPR1A/TNFRSF12A/LIFR/BMP4/CSH2/CD4/TGFBR2/GHR/ACVR2B/CX3CR1/LTBR/IL17RB/IL12RB2/CSF3R/TNFRSF21/GDF15/IL36RN/CSF1R/CSF2RA	-3.67421961778189
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	11/1390	195/9376	0.380505441800406	SLC25A4/PRKCB/HMGB1/SLC25A5/HAT1/FPR2/MAPK1/MAPK13/PIK3R3/HDAC2/AKT3	-3.64702040473253
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	26/1390	370/9376	0.473995722341046	ADRB1/TMEM97/GABRE/PRLR/CHRNA5/GABRA4/NMU/LPAR6/GLRB/CSH2/OGFRL1/GHR/CYSLTR1/S1PR2/FPR2/THRB/CHRNB1/NPFFR2/RLN2/NR3C1/ADRA2C/APELA/HRH1/GRIN2C/PGRMC2/CHRM3	-4.30677865664179
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/1390	143/9376	0.188680384363838	CD28/C1QB/SNRPD1/C1QA	-4.07865491788156
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/1390	449/9376	0.0450689782249924	CAMK2G/CALM2/GNG7	-8.6510892107437