category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	41/564	250/9376	2.72635460992908	MANBA/GNS/GLB1/GAA/SLC38A9/MCOLN3/VPS13C/LGMN/SMPD1/NAGLU/CTSL/CTBS/CLTC/PSAP/PLA2G15/GM2A/TLR3/NPC1/SORT1/ENTPD4/SLC17A5/HGSNAT/SLC15A4/HEXA/AP3M1/CTSV/VPS13A/CTSC/ABCA5/CLN5/ATP6V1B1/CTSF/AP4E1/DMXL2/AP1G1/SLC29A3/CTSO/HEXB/SLC11A2/OSBPL3/TMEM175	6.99918909535628
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	36/564	204/9376	2.93366708385482	FN1/EGFR/MET/IGF1R/HSPG2/ITGB5/ITGAV/ITGB1/TIMP3/ERBB3/GPC3/SLC9A1/CTSL/DCN/GAB1/GPC1/ROCK2/ANK3/PPP1R12A/CTNNB1/SMAD2/KRAS/CASP3/RDX/FZD3/COL1A2/IQGAP1/PPP1R12B/PTK2/SOS1/PIK3CB/FZD5/VAV3/STAT3/CCND1/ROCK1	7.06403286466072
NA	NA	hsa04518	Integrin signaling	30/564	154/9376	3.23846366399558	FN1/FBN1/LAMC1/LAMB1/LAMA5/ITGA6/EGFR/COL4A2/MET/ITGB8/FLT1/ITGB4/CDH1/IGF1R/ITGB5/FRAS1/COL4A1/ITGAV/ITGB1/PDGFD/LAMB2/COL6A1/FREM2/CTNNB1/COL1A2/PTK2/PIK3CB/FERMT1/CCND1/PDGFC	7.08574952746559
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	38/564	233/9376	2.71122880711046	FN1/FBN1/FBN2/ITGA6/COL4A2/DAG1/ITGB8/ITGB4/BGN/HSPG2/ITGB5/COL4A1/FBLN1/PLEC/ITGAV/SYNE2/ITGB1/DIAPH2/SPTBN1/SPTAN1/COL5A2/DMD/SUN1/DAAM1/DSC2/DCN/ATP1B1/DSG2/INF2/ANK3/COL6A1/COL5A3/AMPD2/JUP/COL1A2/MYH10/COL3A1/COL24A1	6.69159471047301
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	30/564	174/9376	2.86622646123747	RRBP1/CANX/GANAB/CKAP4/HSP90B1/STT3B/LMAN1/EDEM3/P4HB/HSPA4L/RPN2/MOGS/OS9/PDIA4/PRKCSH/SEC63/TUSC3/ERLEC1/NFE2L2/SEL1L/WFS1/UBXN4/MAN1B1/MAN1C1/HSPA5/SEC31A/MBTPS2/MAN1A2/STT3A/MBTPS1	6.28616532401418
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	33/564	203/9376	2.7024420920239	FN1/LAMC1/LAMB1/LAMA5/ITGA6/EGFR/COL4A2/MET/ITGB8/FLT1/ITGB4/IGF1R/ITGB5/COL4A1/ARHGAP5/ITGAV/ITGB1/PDGFD/LAMB2/ROCK2/COL6A1/PPP1R12A/CTNNB1/COL1A2/PPP1R12B/PTK2/MYLK3/SOS1/PIK3CB/VAV3/CCND1/PDGFC/ROCK1	6.20372612194447
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	20/564	89/9376	3.7357558371185	FN1/LAMC1/LAMB1/LAMA5/ITGA6/COL4A2/DAG1/ITGB8/ITGB4/HSPG2/ITGB5/FRAS1/COL4A1/ITGAV/ITGB1/CD47/LAMB2/COL6A1/FREM2/COL1A2	6.56028279580949
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	20/564	93/9376	3.5750781667048	EGFR/MET/CDH1/IGF1R/PTPRF/PTPRM/SORBS1/LMO7/CTNND1/TJP1/TCF7L2/ROCK2/CTNNB1/TGFBR2/KRIT1/IQGAP1/NLK/SMURF2/ROCK1/WASL	6.31357961906632
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	34/564	232/9376	2.43629249205185	FN1/ITGA6/EGFR/ITGB8/ITGB4/ITGB5/ITGAV/ITGB1/IQGAP2/DIAPH2/PDGFD/F2R/SLC9A1/SCIN/NCKAP1/ROCK2/PPP1R12A/FGFR2/GNA12/KRAS/RDX/ARHGEF7/IQGAP1/PPP1R12B/PTK2/MYLK3/SOS1/PIK3CB/MYH10/VAV3/PDGFC/ROCK1/WASL/CYFIP1	5.60411088736754
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	28/564	184/9376	2.52975639839655	SEMA6D/PLXNB1/MET/SEMA6A/NRP1/ITGB1/PLXNA1/PLXNB2/SEMA3F/BMPR2/RASA1/NTN4/ROCK2/EPHB4/EFNA4/BMP7/KRAS/NCK1/FZD3/PTK2/PIK3CB/ROBO1/LRIG2/SEMA4B/EFNA5/ROCK1/EPHA1/SEMA3C	5.30168753252043
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	25/564	157/9376	2.64715182725753	CDH1/TEAD1/DLG5/LATS1/BMPR1A/FRMD6/BMPR2/DVL3/RASSF6/TCF7L2/AMOT/BMP7/CTNNB1/TGFBR2/SMAD2/DLG1/FZD3/SAV1/FZD5/YWHAZ/CCND1/PRKCI/TGFB3/SERPINE1/YAP1	5.26537730326153
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	12/564	44/9376	4.53384912959381	MAN2A1/STT3B/FUT8/RPN2/B4GALT1/TUSC3/HEXA/MAN1B1/MAN1C1/MAN1A2/STT3A/HEXB	5.94394693250095
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	43/564	362/9376	1.97468751224482	FN1/LAMC1/LAMB1/LAMA5/ITGA6/EGFR/COL4A2/MET/ITGB8/FLT1/ITGB4/IGF1R/CDK6/ITGB5/COL4A1/CREB3L2/CSF3R/ITGAV/ITGB1/PRLR/PDGFD/HSP90B1/ERBB3/F2R/LAMB2/CSH1/PHLPP1/COL6A1/EFNA4/PKN2/FGFR2/KRAS/IL4R/COL1A2/PTK2/SOS1/PIK3CB/PPP2R3A/BCL2L1/YWHAZ/CCND1/EFNA5/PDGFC	4.78463547809968
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	13/564	56/9376	3.85916919959473	GANAB/MAN2A1/STT3B/FUT8/RPN2/B4GALT1/MOGS/TUSC3/MAN1B1/MGAT3/MAN1C1/MAN1A2/STT3A	5.42892522576294
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	39/564	333/9376	1.94696824484059	FN1/LAMC1/LAMB1/LAMA5/ITGA6/EGFR/COL4A2/ITGB8/ITGB4/CDK6/ITGB5/COL4A1/CREB3L2/ITGAV/ITGB1/LAMB2/UBR4/DVL3/NOTCH3/TCF7L2/TLR3/COL6A1/CTNNB1/MAML2/JAG1/KRAS/CASP3/DLG1/FZD3/COL1A2/PTK2/ATP6V1B1/SOS1/PIK3CB/FZD5/PPP2R3A/CCND1/PRKCI/PSEN1	4.45132406711831
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	16/564	93/9376	2.86006253336384	FN1/LAMC1/LAMB1/LAMA5/ITGA6/COL4A2/CDK6/COL4A1/ITGAV/ITGB1/LAMB2/CASP3/PTK2/PIK3CB/BCL2L1/CCND1	4.56050346458515
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	15/564	86/9376	2.89955467590302	ITGA6/DAG1/ITGB8/ITGB4/ITGB5/ITGAV/ITGB1/DMD/DSC2/GJA1/DSG2/TCF7L2/CTNNB1/JUP/ATP2A2	4.47693834214361
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	23/564	170/9376	2.24914476428869	EGFR/MET/IGF1R/CDK6/LRP5/SMARCA2/GAB1/DVL3/ARID1A/TCF7L2/NFE2L2/CTNNB1/TGFBR2/SMAD2/KRAS/FZD3/SOS1/PIK3CB/FZD5/BCL2L1/PBRM1/CCND1/TGFB3	4.15804986590107
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	29/564	238/9376	2.02562727218547	EGFR/RPL39/IL6ST/NRP1/RPS29/RPS28/RPS27/RPL34/RPL36/FAU/RPS15/RPL28/RPL37A/RPS15A/TLR3/RPL18/RPL12/RPL21/RPS27A/RPL41/RPLP2/RPL37/PIK3CB/RPL10/MAVS/RPS12/STAT3/RPL35A/RPS21	4.05452897296891
NA	NA	hsa04517	IgSF CAM signaling	34/564	299/9376	1.89036741858203	NRP2/CDH1/APP/NRCAM/NRP1/PTPRF/ITGB1/PLXNA1/SPTBN1/SPTAN1/TJP2/SORBS1/LMO7/MTSS1/RASA1/TJP1/ANK3/CTNNB1/NLGN4X/CD226/NLGN1/NCK1/RDX/IQGAP1/PTK2/MYLK3/PIK3CB/CADM1/MYH10/ROBO1/VAV3/PRKCI/WASL/F11R	3.95841780826381
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	14/564	80/9376	2.90921985815603	EGFR/MET/IGF1R/PDGFD/ERBB3/NF1/GAB1/FGFR2/KRAS/SOS1/PIK3CB/BCL2L1/STAT3/PDGFC	4.3385122178376
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/564	103/9376	2.58238655925084	COL4A2/COL14A1/COL4A1/SLC38A2/DPP4/COL5A2/COL21A1/MME/ATP1B1/SLC7A8/COL6A1/COL5A3/COL1A2/COL3A1/KCNK5/COL24A1	4.08515946337111
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	16/564	106/9376	2.50930014719657	EGFR/SPINT1/IGF1R/CREB3L2/SLC19A1/PDGFD/HSP90B1/TCF7L2/CTNNB1/FGFR2/KRAS/SOS1/PIK3CB/CCND1/FOLR1/PDGFC	3.95345341683265
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	6/564	19/9376	5.24972004479283	GNS/GLB1/NAGLU/HGSNAT/HEXA/HEXB	4.69090624548221
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	20/564	150/9376	2.21654846335697	EGFR/MET/CDH1/LRP5/GAB1/DVL3/TCF7L2/CTNNB1/TGFBR2/SMAD2/FGFR2/JUP/KRAS/FZD3/SOS1/PIK3CB/FZD5/CCND1/TGFB3/ABCB1	3.79976085933394
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	16/564	110/9376	2.4180528691167	FBN1/LTBP1/BMPR1A/BMPR2/DCN/ACVR2B/BMP7/TGFBR2/SMAD2/ACVR2A/SP1/SMURF2/TFRC/ROCK1/TGFB3/ZFYVE16	3.7846921857571
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	15/564	101/9376	2.46892774383821	FN1/COL4A2/COL4A1/EDN1/TGFBR2/SMAD2/KRAS/CASP3/COL1A2/PIK3CB/COL3A1/STAT3/CCND1/TGFB3/SERPINE1	3.75484580538131
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/564	21/9376	4.74974670719352	CHPF/B3GAT3/DSE/CHST12/CHST14/XYLT1	4.35188719811747
NA	NA	hsa04519	Cadherin signaling	40/564	404/9376	1.64595182922548	EGFR/MET/DSC3/CDH1/IGF1R/LRP5/GABRE/TEAD1/TAOK1/FAT1/DAAM1/DSC2/LATS1/NCKAP1/PCDH11X/GJA1/CTNND1/TJP1/DVL3/DSG2/KRT80/TCF7L2/PSEN2/ROCK2/ADAM10/CTNNB1/TMC5/JUP/KRAS/FZD3/PTK2/SAV1/NCSTN/FZD5/VAV3/YWHAZ/ROCK1/PSEN1/CYFIP1/YAP1	3.35763998787156
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/564	55/9376	3.02256608639587	PLPP3/GLB1/SMPD1/PSAP/SGPP1/GM2A/DEGS1/HEXA/SAMD8/HEXB	3.80575439507212
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/564	99/9376	2.35088473386346	EGFR/PLPP3/SLC44A2/PDGFD/SLC44A1/SLC22A5/SLC44A5/DGKD/KRAS/SP1/SOS1/PIK3CB/PDGFC/DGKH	3.41837779522034
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	6/564	24/9376	4.15602836879433	EXTL2/HS6ST2/B3GAT3/EXT2/GLCE/XYLT1	3.91635648157913
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	18/564	144/9376	2.07801418439716	IL6ST/IGF1R/LIFR/ZFHX3/BMPR1A/BMPR2/DVL3/ACVR2B/CTNNB1/RIF1/SMAD2/ACVR2A/FGFR2/KRAS/FZD3/PIK3CB/FZD5/STAT3	3.297962927232
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	16/564	122/9376	2.18021160330194	ITGAV/MED13/SLC9A1/NCOA3/ATP1B1/MED12/NOTCH3/CTNNB1/SLC2A1/KRAS/THRB/PIK3CB/SLC16A2/RCAN1/CCND1/ATP2A2	3.31942601878351
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/564	17/9376	4.88944513975803	DAG1/NRP2/PCDH11X/TFRC/MYH10	4.06055440001448
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	19/564	157/9376	2.01183538871572	LRP1/ITGB5/ITGAV/ANO6/PBX1/CD47/ABCA1/DNMT3A/TMEM30B/ADAM9/PLA2G15/ADAM10/TMEM30A/SLC2A1/CASP3/PTK2/P2RY6/ATP2A2/RAB14	3.23448937870595
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/564	103/9376	2.25958823934449	FN1/LAMC1/LAMB1/LAMA5/COL4A2/COL4A1/LAMB2/GNAQ/CASP3/COL1A2/PTK2/PIK3CB/COL3A1/TGFB3	3.25180897539044
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	10/564	62/9376	2.6813086250286	TLE4/DVL3/NOTCH3/PSEN2/DTX4/MAML2/JAG1/SPEN/NCSTN/PSEN1	3.36018442756215
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	11/564	78/9376	2.34442625931988	FN1/MET/CDH1/ITGB1/CLTC/GAB1/DNM3/CTNNB1/PTK2/PIK3CB/WASL	3.01632034133542
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	6/564	29/9376	3.43947175348496	TEAD1/LATS1/FRMD6/RASSF6/SAV1/YAP1	3.32848510148083
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	17/564	148/9376	1.90952654782442	EGFR/IGF1R/CDK6/LRP5/NCOA3/DVL3/NOTCH3/TCF7L2/CTNNB1/JAG1/KRAS/FZD3/SP1/SOS1/PIK3CB/FZD5/CCND1	2.82150218394633
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	22/564	212/9376	1.72514385119764	EGFR/MET/FLT1/CDH1/IGF1R/ITGB1/PDGFD/F2R/GNAQ/LAT/CTNND1/EFNA4/CTNNB1/KRIT1/FGFR2/KRAS/PIK3CB/P2RY1/VAV3/EFNA5/PRKCI/PDGFC	2.70170237718909
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	19/564	178/9376	1.77448402263129	LGR5/RNF43/LRP5/LGR4/TLE4/TBL1X/ZNRF3/DAAM1/DVL3/SERPINF1/NOTUM/TCF7L2/ROCK2/CTNNB1/FZD3/NLK/FZD5/CCND1/PSEN1	2.6391477674875
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/564	73/9376	2.27727581851744	EGFR/MET/CDH1/IGF1R/CDK6/PDGFD/KRAS/PIK3CB/CCND1/PDGFC	2.77154896504812
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	9/564	63/9376	2.37487335359676	KMT2C/ASH1L/PLOD2/KMT2A/NSD1/PLOD1/HADHA/SETD2/KMT2E	2.76997668873179
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	13/564	108/9376	2.00105069608616	THOC2/UPF2/RANBP17/KPNB1/IPO7/PNN/NUP58/RANBP2/NUP210/UPF3A/KPNA3/TNPO1/TMEM33	2.64705450027826
Genetic Information Processing	Translation	hsa03010	Ribosome	22/564	222/9376	1.64743466871126	RPL39/RPS29/RPS28/RPS27/RPL34/RPL36/FAU/RPS15/RPL28/RPL37A/RPS15A/RPL18/RPL12/RPL21/RPS27A/RPL41/RPLP2/RPL37/RPL10/RPS12/RPL35A/RPS21	2.46976101103923
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	11/564	87/9376	2.10189940490748	EGFR/TCF7L2/CTNNB1/TGFBR2/SMAD2/KRAS/CASP3/SOS1/PIK3CB/CCND1/TGFB3	2.6121916648241
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/564	77/9376	2.15897577599705	EGFR/CDK6/TGFBR2/SMAD2/KRAS/PIK3CB/BCL2L1/STAT3/CCND1/TGFB3	2.58338743809123
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/564	26/9376	3.19694489907256	SLC19A3/SLC19A1/LMBRD1/SLC52A3/SLC5A6	2.83784047866014
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/564	18/9376	3.69424743892829	MANBA/GLB1/HEXA/HEXB	2.8944773588181
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/564	59/9376	2.25411708137997	EGFR/CDH1/TCF7L2/CTNNB1/KRAS/SOS1/PIK3CB/CCND1	2.4446347850914
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	17/564	170/9376	1.66241134751773	ITGB1/MAP3K1/TJP2/TJP1/CLDN4/MARVELD2/AMOT/ROCK2/DLG1/RDX/MYH10/MARVELD3/CCND1/SYNPO/PRKCI/ROCK1/F11R	2.20498015399029
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/564	61/9376	2.18021160330194	TRPV6/ATP2B1/ATP2B4/ATP1B1/ATP7B/SLC40A1/TRPM7/SLC11A2	2.33949065063938
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/564	73/9376	2.04954823666569	EGFR/MET/CDK6/EML4/KRAS/SOS1/PIK3CB/STAT3/CCND1	2.27740499501139
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	11/564	99/9376	1.84712371946414	EGFR/IGF1R/NCOA3/NOTCH3/JAG1/KRAS/PTK2/SP1/SOS1/PIK3CB/CCND1	2.14362398199504
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	11/564	99/9376	1.84712371946414	ITGA6/DAG1/ITGB8/ITGB4/ITGB5/ITGAV/ITGB1/DMD/EDN1/ATP2A2/TGFB3	2.14362398199504
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/564	75/9376	1.99489361702128	CDK6/MDM4/CASP3/SESN1/BCL2L1/CCND1/RRM2B/PPP1R13L/SERPINE1	2.1884186136038
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/564	75/9376	1.99489361702128	LRP2/CREB3L2/CANX/HSP90B1/GNAQ/ATP1B1/PDIA4/GPX8/HSPA5	2.1884186136038
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	12/564	112/9376	1.78115501519757	LAMC1/LAMB1/LAMA5/ITGA6/ITGB1/IFNGR1/LAMB2/CASP3/BCL2L1/STAT3/TAB1/TGFB3	2.10394755256831
Organismal Systems	Immune system	hsa04611	Platelet activation	13/564	126/9376	1.71518631093099	ITGB1/F2R/GNAQ/ROCK2/PPP1R12A/COL1A2/MYLK3/PIK3CB/P2RY1/COL3A1/BTK/PRKCI/ROCK1	2.04466209255331
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	9/564	77/9376	1.94307819839735	CDK6/TGFBR2/KRAS/SOS1/PIK3CB/BCL2L1/CCND1/TGFB3/BCR	2.10214606839514
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	16/564	166/9376	1.60232419037854	ADRB1/CREB3L2/ATP2B1/ATP2B4/GNAQ/ATP1B1/ROCK2/PPP1R12A/MEF2A/GNA12/PDE5A/GTF2I/MYLK3/EDNRB/ROCK1/ATP2A2	1.98080845179804
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	14/564	142/9376	1.63899710318649	ITGAV/HSP90B1/BMPR1A/BMPR2/CTSL/ACVR2B/NFE2L2/EDN1/GPC1/CTNNB1/ACVR2A/MEF2A/PTK2/PIK3CB	1.94104709373085
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/564	14/9376	3.56231003039514	B3GNT2/FUT8/B4GALT1	2.4271651182536
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	13/564	130/9376	1.66241134751773	EGFR/COL4A2/COL4A1/CREB3L2/EDN1/TGFBR2/SMAD2/KRAS/COL1A2/SOS1/PIK3CB/COL3A1/EDNRB	1.92402380536452
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/564	105/9376	1.74157379263762	ITGA6/DAG1/ITGB8/ITGB4/ADRB1/ITGB5/ITGAV/ITGB1/DMD/ATP2A2/TGFB3	1.93318616450971
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	27/564	323/9376	1.38963177656281	EGFR/MET/CDK6/TIMP3/MDM4/ST14/ERBB3/DNMT3A/BMPR2/DICER1/NOTCH3/EFNA4/RPS6KA5/FOXP1/KRAS/CASP3/RDX/FZD3/ZEB2/SOS1/PIK3CB/HDAC5/STAT3/CCND1/EFNA5/ROCK1/ABCB1	1.80279902960033
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/564	15/9376	3.32482269503546	GLB1/HEXA/HEXB	2.2796191123042
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	15/564	160/9376	1.55851063829787	ITGA6/ITGB8/CDH1/NRCAM/ITGAV/PTPRF/ITGB1/PTPRM/GLG1/CLDN4/NLGN4X/CD226/NLGN1/CADM1/F11R	1.80263647335486
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/564	70/9376	1.89989868287741	MET/GAB1/EPAS1/SLC2A1/KRAS/SOS1/PIK3CB/TGFB3	1.91182905729927
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/564	36/9376	2.30890464933018	GALNT11/GALNT18/GCNT4/B3GNT3/C1GALT1	1.9905531057844
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	11/564	110/9376	1.66241134751773	EGFR/FLT1/IGF1R/IFNGR1/EPAS1/EDN1/SLC2A1/PIK3CB/TFRC/STAT3/SERPINE1	1.76793341440704
NA	NA	hsa03272	Virion - Hepatitis viruses	6/564	48/9376	2.07801418439716	EGFR/HSPG2/DPP4/TGOLN2/CLDN4/IST1	1.89425643478725
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/564	37/9376	2.24650182096991	CDH1/TCF7L2/CTNNB1/KRAS/CCND1	1.9219033225125
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/564	138/9376	1.56603967519786	FN1/ITGB1/GNAQ/LAT/ROCK2/PKN2/ARHGEF7/PTK2/PIK3CB/VAV3/ROCK1/TAB1/WASL	1.69467094387262
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/564	86/9376	1.73973280554181	EGFR/ERBB3/GAB1/ABL2/KRAS/NCK1/PTK2/SOS1/PIK3CB	1.74342871099367
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/564	101/9376	1.64595182922548	CREB3L2/GNAQ/DVL3/TCF7L2/EDN1/CTNNB1/KRAS/FZD3/FZD5/EDNRB	1.65117006375556
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	14/564	155/9376	1.50153283001601	EGFR/CDK6/CREB3L2/PBX1/AHR/GNAQ/DVL3/TCF7L2/CTNNB1/KMT2A/FZD3/SP1/FZD5/CCND1	1.59281065036883
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/564	28/9376	2.37487335359676	B3GNT2/B4GALT1/B3GNT5/B3GNT3	1.84319084548866
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	11/564	115/9376	1.59013259327783	EGFR/LRP5/CREB3L2/MMP15/GNAQ/MMP14/AKAP13/MEF2A/WNK2/GNA12/SP1	1.61085899155035
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/564	89/9376	1.68109012670332	EGFR/ADRB1/PDGFD/GNAQ/GJA1/TJP1/KRAS/SOS1/PDGFC	1.63323926060364
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	14/564	156/9376	1.49190761956719	EGFR/CDK6/CLDN4/TLR3/CTNNB1/KRAS/CASP3/CFLAR/SOS1/PIK3CB/MAVS/STAT3/YWHAZ/CCND1	1.56735846710358
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/564	116/9376	1.57642455368061	ARHGAP5/ITGB1/CTNND1/CLDN4/ROCK2/CTNNB1/PTK2/PIK3CB/VAV3/ROCK1/F11R	1.5803523231435
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/564	52/9376	1.91816693944354	LRP2/LRP1/APOE/ABCA1/NPC1/SORT1	1.67961651549278
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/564	53/9376	1.88197511039743	ATP2B1/ATP2B4/GNAQ/CLTC/ATP1B1/DNM3	1.6289372999174
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/564	41/9376	2.02733091160699	EGFR/CDH1/RPS6KA5/KRAS/CCND1	1.66775814013643
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	13/564	149/9376	1.45042600790138	EGFR/PLPP3/PDGFD/F2R/GAB1/DNM3/DGKD/GNA12/KRAS/SOS1/PIK3CB/PDGFC/DGKH	1.40208479266797
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	14/564	163/9376	1.42783796719314	HSPG2/CREB3L2/MAP3K1/TLR3/TGFBR2/KRAS/CASP3/SOS1/PIK3CB/MAVS/STAT3/YWHAZ/TAB1/TGFB3	1.39399281299089
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/564	68/9376	1.71130579891531	TCF7L2/JUP/KRAS/SOS1/PIK3CB/STAT3/CCND1	1.4892601348882
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/564	70/9376	1.66241134751773	DAG1/DMD/ABL2/EIF4G2/CASP3/CCND1/EIF4G1	1.40728871612504
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	20/564	254/9376	1.30898531300609	EGFR/MET/FLT1/ADRB1/ATP2B1/ATP2B4/PHKB/PDGFD/MCOLN3/ERBB3/F2R/ASPH/GNAQ/PHKA2/FGFR2/MYLK3/P2RX4/EDNRB/PDGFC/ATP2A2	1.26298329664959
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/564	71/9376	1.63899710318649	EGFR/MET/TJP1/ADAM10/CASP3/ATP6V1B1/F11R	1.3672811326036
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/564	140/9376	1.42492401215805	CDH1/SLC9A1/GNAQ/NOTCH3/SMAD2/MEF2A/JAG1/KRAS/MYLK3/HDAC5/CCND1/SERPINE1	1.28150786265075
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	23/564	300/9376	1.27451536643026	EGFR/MET/FLT1/IGF1R/MAP3K1/TAOK1/PDGFD/ERBB3/NF1/RASA1/EFNA4/TGFBR2/FGFR2/RPS6KA5/GNA12/KRAS/CASP3/SOS1/NLK/EFNA5/PDGFC/TAB1/TGFB3	1.22255382703933
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	18/564	227/9376	1.31821164120349	EGFR/CDK6/CREB3L2/ITGAV/GNAQ/ROCK2/CTNNB1/AKAP13/GNA12/KRAS/CASP3/PTK2/SP1/SOS1/PIK3CB/STAT3/CCND1/ROCK1	1.22780705422021
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	13/564	155/9376	1.39428048501487	COLEC12/ITGB5/ITGAV/CANX/ITGB1/EEA1/OLR1/CTSL/DYNC1H1/STX7/ATP6V1B1/TFRC/PLA2R1	1.25218952415183
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	16/564	200/9376	1.32992907801418	ITGB1/F2R/NCKAP1/MYO6/TJP1/CLDN4/ROCK2/GNA12/CASP3/NCK1/MYH10/ROCK1/TAB1/ABI1/WASL/CYFIP1	1.19315491542044
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/564	158/9376	1.36780680491965	IGF1R/LRP5/CLIP1/SLC38A9/DVL3/KRAS/LPIN1/FZD3/ATP6V1B1/SOS1/PIK3CB/FZD5/RICTOR	1.17955418973537
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/564	23/9376	2.16836262719704	ENPEP/MME/LNPEP	1.41923415217117
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/564	12/9376	2.77068557919622	CD46/NPC1	1.55270630593396
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/564	49/9376	1.69633810971197	GALNT11/GXYLT1/B4GALT1/GALNT18/C1GALT1	1.23633214678823
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/564	76/9376	1.53116834639791	EGFR/IGF1R/CDK6/KRAS/SOS1/PIK3CB/CCND1	1.17621158948649
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/564	63/9376	1.58324890239784	DVL3/GLI3/TCF7L2/CTNNB1/FZD3/FZD5	1.17507976945217
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/564	134/9376	1.36466603154441	GNAQ/EDN1/ROCK2/PPP1R12A/GNA12/PPP1R12B/MYLK3/MYH10/ROCK1/PPP1R14A/CALD1	1.07560465707156
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	18/564	238/9376	1.25728589308064	EGFR/MET/FLT1/IGF1R/PDGFD/LAT/NF1/GAB1/RASA1/EFNA4/ABL2/FGFR2/KRAS/SOS1/PIK3CB/BCL2L1/EFNA5/PDGFC	1.01710741915897
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/564	93/9376	1.43003126668192	ADRB1/TRPV6/ATP2B1/ATP2B4/SLC9A1/GNAQ/ATP1B1/LYZ	1.0543511556228
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	11/564	137/9376	1.33478283377336	SPTAN1/CTSL/CTSV/CTSC/KRAS/CASP3/CFLAR/CTSF/PIK3CB/BCL2L1/CTSO	0.998616935842228
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	13/564	168/9376	1.28638973319824	EGFR/IL6ST/CSF3R/LIFR/PRLR/IFNGR1/CSH1/IL4R/SOS1/PIK3CB/BCL2L1/STAT3/CCND1	0.947583252356385
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/564	125/9376	1.32992907801418	SMPD1/GNAQ/SGPP1/ROCK2/DEGS1/GNA12/KRAS/PIK3CB/PPP2R3A/ROCK1	0.939440340707064
NA	NA	hsa04382	Cornified envelope formation	16/564	217/9376	1.22574108572736	LAMA5/ITGA6/COL4A2/DST/ITGB4/COL4A1/PLEC/ST14/PRSS8/TJP1/CLDN4/DSG2/KRT80/JUP/SLC27A4/PPP2R3A	0.851146647469624
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/564	69/9376	1.44557508479803	LAT/KRAS/SOS1/PIK3CB/VAV3/BTK	0.939785051627783
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/564	28/9376	1.78115501519757	HACD3/HADHA/HACD2	1.04723665576401
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/564	42/9376	1.58324890239784	LPCAT3/SLC40A1/TFRC/SLC11A2	0.958368703729039
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/564	16/9376	2.07801418439716	HEXA/HEXB	1.09177837568913
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/564	71/9376	1.40485465987414	PRLR/KRAS/SOS1/PIK3CB/STAT3/CCND1	0.866279573306608
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/564	71/9376	1.40485465987414	EGFR/MET/SLC2A1/FGFR2/KRAS/PIK3CB	0.866279573306608
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/564	30/9376	1.66241134751773	SLC19A1/MTR/FOLR1	0.91931309954576
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	9/564	117/9376	1.27877795962902	BPTF/SMARCA2/ARID1A/RSF1/TRRAP/BAZ2A/EPC1/INO80D/PBRM1	0.767639422334354
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	10/564	133/9376	1.24993334399829	EGFR/IGF1R/TGFBR2/KRAS/SOS1/NLK/PIK3CB/STAT3/CCND1/TGFB3	0.734398007343688
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	8/564	103/9376	1.29119327962542	RNMT/UPF2/SMG1/PNN/CPSF7/UPF3A/GSPT1/PPP2R3A	0.751757511448432
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/564	103/9376	1.29119327962542	IFNGR1/GNAQ/TGFBR2/SMAD2/CFLAR/PIK3CB/TGFB3/SERPINE1	0.751757511448432
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	16/564	226/9376	1.17692838762317	ADRB1/CREB3L2/ATP2B1/ATP2B4/PDE10A/F2R/SLC9A1/ATP1B1/GLI3/EDN1/ROCK2/PPP1R12A/PIK3CB/VAV3/ROCK1/ATP2A2	0.681128634364002
NA	NA	hsa04981	Folate transport and metabolism	3/564	31/9376	1.60878517501716	SLC19A1/MTR/FOLR1	0.858901197160813
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	9/564	119/9376	1.25728589308064	CREB3L2/MMP14/EDN1/JAG1/RPS6KA5/CASP3/CFLAR/PIK3CB/TAB1	0.714565870581473
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	8/564	104/9376	1.27877795962902	PLPP3/LPCAT3/PLA2G15/DGKD/SAMD8/LPIN1/CDS1/DGKH	0.723229844574825
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/564	18/9376	1.84712371946414	MTR/LMBRD1	0.910079894919408
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/564	120/9376	1.2468085106383	MAP3K1/GAB1/PSEN2/SORT1/RPS6KA5/KRAS/SOS1/PIK3CB/PSEN1	0.688378071510796
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	7/564	90/9376	1.2929866036249	EGFR/IFNGR1/LAT/EML4/KRAS/PIK3CB/STAT3	0.706549550357909
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/564	32/9376	1.55851063829787	GLB1/GAA/B4GALT1	0.800622830094455
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/564	32/9376	1.55851063829787	ACSS1/ACACA/HADHA	0.800622830094455
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/564	32/9376	1.55851063829787	BIRC6/CASP3/BCL2L1	0.800622830094455
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/564	122/9376	1.22636902685734	CREB3L2/MAP3K1/CSH1/GNAQ/KRAS/PTK2/SOS1/PIK3CB/STAT3	0.636678401987144
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	10/564	138/9376	1.20464590399836	PTPRF/PHKB/SORBS1/PHKA2/INPPL1/ACACA/KRAS/SOS1/PIK3CB/PRKCI	0.612691093018046
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	15/564	216/9376	1.15445232466509	VLDLR/HSP90B1/OLR1/ABCA1/NFE2L2/ROCK2/KRAS/CASP3/PTK2/PIK3CB/HSPA5/BCL2L1/VAV3/STAT3/TAB1	0.580980470513807
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	14/564	201/9376	1.15789845100737	SPINT1/MET/FLT1/IGF1R/PBX1/FUT8/TGFBR2/KMT2A/JUP/PTK2/SP1/BCL2L1/ASPSCR1/HHEX	0.572480644446174
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/564	109/9376	1.2201184201965	IL6ST/IFNGR1/AHR/LAT/TGFBR2/SMAD2/IL4R/STAT3	0.58477392683372
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	8/564	109/9376	1.2201184201965	CREB3L2/PTPRF/SLC27A2/SLC2A1/SLC27A4/SLC27A6/PIK3CB/STAT3	0.58477392683372
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	17/564	250/9376	1.13043971631206	EGFR/IGF1R/EEA1/CLTC/DNM3/EPN3/TGFBR2/SMAD2/FGFR2/SMURF2/TFRC/PSD3/FOLR1/PRKCI/WASL/IST1/ZFYVE16	0.528843978381835
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/564	34/9376	1.46683354192741	NR1D2/FBXL3/BHLHE41	0.689873599613317
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/564	79/9376	1.26259089684891	SLC6A4/SLC1A3/CLTC/DNM3/ATP6V1B1/SLC6A2	0.592938625907917
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	11/564	157/9376	1.16474680399331	CDK6/ZFP36L1/TGFBR2/SMAD2/TRPM7/KRAS/PIK3CB/HIPK2/CCND1/TGFB3/SERPINE1	0.52663881263184
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/564	66/9376	1.25940253599828	IFNGR1/SMAD2/IL4R/STAT3/TGFB3	0.53500678620982
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/564	51/9376	1.30385203726881	TJP2/PDIA4/TJP1/ATP6V1B1	0.550440988770366
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	6/564	83/9376	1.2017431427839	LCOR/PHC3/MTF2/PHC1/MGA/TEX10	0.467033255110233
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	13/564	196/9376	1.10261977131278	IL6ST/CDK6/IFNGR1/TCF7L2/TLR3/CTNNB1/KRAS/CASP3/RPS27A/PIK3CB/RCAN1/STAT3/CCND1	0.367304021668707
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/564	38/9376	1.31243001119821	ATP1B1/KRAS/PIK3CB	0.488208744361845
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/564	23/9376	1.44557508479803	B4GALT1/B4GAT1	0.541249234596817
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/564	23/9376	1.44557508479803	PCYOX1/HMGCR	0.541249234596817
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/564	102/9376	1.14087053261021	ATP2B1/ATP2B4/SLC9A1/RAB27B/GNAQ/ATP1B1/ATP2A2	0.361888383533832
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/564	39/9376	1.27877795962902	GLDC/MTR/AHCYL1	0.441341742379017
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	14/564	217/9376	1.07252345001144	EGFR/ADRB1/CREB3L2/HSP90B1/AHR/PAQR7/KPNB1/JAG1/KRAS/SOS1/PIK3CB/KPNA3/STAT3/CCND1	0.273446418232966
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/564	56/9376	1.18743667679838	LRP2/GLI3/SMURF2/CCND1	0.355900484325352
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/564	154/9376	1.07948788799853	ADRB1/CREB3L2/ATP2B1/ATP2B4/SLC9A1/GNAQ/ATP1B1/RPS6KA5/PPP2R3A/ATP2A2	0.251615102752862
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	10/564	154/9376	1.07948788799853	EGFR/GNAQ/ROCK2/PPP1R12A/KRAS/PPP1R12B/MYLK3/RCAN1/CCND1/ROCK1	0.251615102752862
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/564	57/9376	1.16660445439841	HACD3/ACACA/HADHA/HACD2	0.319173867883764
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	8/564	122/9376	1.09010580165097	IGF1R/CREB3L2/ACACA/HMGCR/PIK3CB/PPP2R3A/CCND1/RAB14	0.253428742444806
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	8/564	122/9376	1.09010580165097	LAT/KRAS/DLG1/NCK1/SOS1/PIK3CB/PPP2R3A/VAV3	0.253428742444806
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	9/564	139/9376	1.07638144803306	EGFR/CREB3L2/HSP90B1/NCOA3/GNAQ/KRAS/SP1/SOS1/PIK3CB	0.229518534220199
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	13/564	205/9376	1.05421207403563	IL6ST/CDK6/CREB3L2/SCIN/UBR4/KRAS/CASP3/DLG1/PIK3CB/HDAC5/STAT3/YWHAZ/CCND1	0.198542073196666
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/564	91/9376	1.09609539396773	INPPL1/KRAS/SOS1/PIK3CB/VAV3/BTK	0.233034520402068
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/564	75/9376	1.10827423167849	TOP2B/ATP7B/CASP3/PIK3CB/BCL2L1	0.238165508276433
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	14/564	224/9376	1.03900709219858	CREB3L2/NRP1/CANX/MAP3K1/TGFBR2/SMAD2/SLC2A1/KRAS/DLG1/TRRAP/PIK3CB/BCL2L1/CCND1/TGFB3	0.149484969178976
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	10/564	158/9376	1.05215908070742	CDK6/CDKN1C/PRKDC/SMAD2/NIPBL/PDS5B/PDS5A/YWHAZ/CCND1/TGFB3	0.167273855073529
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/564	43/9376	1.15982187036121	PLPP3/ABCA1/SLC27A4	0.265734382291634
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/564	76/9376	1.09369167599851	OLR1/SORBS1/SLC27A2/SLC27A4/SLC27A6	0.207469507351446
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/564	27/9376	1.2314158129761	HACD3/HACD2	0.3046353374585
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/564	93/9376	1.07252345001144	IFNGR1/LAT/NOTCH3/MAML2/JAG1/IL4R	0.177813078382209
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/564	93/9376	1.07252345001144	EGFR/MAP3K1/GNAQ/MMP14/KRAS/SOS1	0.177813078382209
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/564	60/9376	1.10827423167849	IGF1R/GNAQ/GNA12/KRAS	0.212850140821179
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/564	45/9376	1.10827423167849	ABCA1/ABCA5/ABCB1	0.184185407279675
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	15/564	248/9376	1.00549073438572	AHNAK/HSP90B1/NCKAP1/MYO6/DYNC1H1/TCF7L2/ROCK2/CTNNB1/CASP3/PIK3CB/KPNA3/TAB1/ABI1/WASL/CYFIP1	0.0221695259075404
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/564	98/9376	1.01780286582718	INPPL1/DGKD/PIK3CB/CDS1/IP6K2/DGKH	0.0448191605910959
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	6/564	98/9376	1.01780286582718	PLPP3/SCIN/LAT/INPPL1/PIK3CB/VAV3	0.0448191605910959
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/564	47/9376	1.06111362607515	ACSS1/PC/ACACA	0.10625695862299
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/564	30/9376	1.10827423167849	PGAP1/PIGM	0.150266024122754
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/564	13/9376	1.27877795962902	PRKDC	0.254454740137181
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/564	65/9376	1.02302236770322	PLPP3/DGKD/LPIN1/DGKH	0.0471190414500325
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/564	65/9376	1.02302236770322	CREB3L2/PBX1/GNAQ/SP1	0.0471190414500325
NA	NA	hsa04081	Hormone signaling	13/564	219/9376	0.986819521357557	IGF1R/ADRB1/ITGAV/PRLR/CSH1/BMPR1A/GNAQ/SLC40A1/GNA12/THRB/PIK3CB/SLC16A2/STAT3	-0.0499303462796886
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/564	31/9376	1.07252345001144	GLDC/ACSS1	0.10231930834272
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/564	31/9376	1.07252345001144	SEC63/HSPA5	0.10231930834272
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	10/564	169/9376	0.983675353560787	IGF1R/BIRC6/CTSL/WDFY3/KRAS/CFLAR/RPS27A/STX7/PIK3CB/BCL2L1	-0.0541771319854019
Human Diseases	Infectious disease: viral	hsa05162	Measles	8/564	136/9376	0.977889027951606	CDK6/CD46/CASP3/PIK3CB/MAVS/BCL2L1/STAT3/CCND1	-0.0657096645478551
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/564	50/9376	0.997446808510638	AOC1/ALDH18A1/ALDH4A1	-0.00457940053639297
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/564	50/9376	0.997446808510638	LRP1/MET/TGFB3	-0.00457940053639297
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/564	86/9376	0.966518225301006	CREB3L2/GNAQ/ATP1B1/SLC2A1/PCLO	-0.078911043106291
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/564	15/9376	1.10827423167849	TPK1	0.106168960080875
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/564	87/9376	0.955408820412489	SLC9A1/ASPH/ATP1B1/SLC9A7/ATP2A2	-0.105709021281259
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/564	105/9376	0.949949341438703	LAT/CFLAR/BCL2L1/BTK/TAB1/PPP1R13L	-0.130475539475516
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/564	88/9376	0.944551901998711	F5/CD46/F2R/SERPINE2/SERPINE1	-0.132207116173666
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	8/564	142/9376	0.936569773249426	MAP3K1/BIRC6/UBR5/HERC4/CUL5/RPS27A/UBE4A/SMURF2	-0.192678584417553
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/564	107/9376	0.932193278981905	CREB3L2/PHKB/GNAQ/PHKA2/ACACA/SLC2A1	-0.178458047501582
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/564	90/9376	0.923561859732072	IGF1R/CREB3L2/KRAS/SESN1/PIK3CB	-0.184333798775463
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/564	90/9376	0.923561859732072	SLC9A1/ATP1B1/SLC2A1/HMGCR/ABCB1	-0.184333798775463
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/564	54/9376	0.923561859732072	MTR/DNMT3A/AHCYL1	-0.142508375268289
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/564	36/9376	0.923561859732072	AGL/GAA	-0.11624542520234
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/564	73/9376	0.910910327406976	AFF4/RANBP2/CPSF7/MAP1S	-0.193314855172216
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/564	17/9376	0.977889027951606	MTR	-0.0230837051593658
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/564	18/9376	0.923561859732072	ACACA	-0.0821188370299372
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/564	38/9376	0.874953340798805	HEXA/HEXB	-0.195400154553427
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/564	76/9376	0.874953340798805	SLC9A1/GNAQ/ATP1B1/MYLK3	-0.276901533716074
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/564	19/9376	0.874953340798805	GLDC	-0.138028422682173
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/564	133/9376	0.874953340798805	IFNGR1/LAT/KRAS/CASP3/SOS1/PIK3CB/VAV3	-0.36743403610432
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/564	78/9376	0.852518639752682	ITGB1/IFNGR1/TAB1/TGFB3	-0.330885404683217
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/564	60/9376	0.831205673758865	KRAS/PTK2/PIK3CB	-0.331823145297645
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	5/564	98/9376	0.848169054855985	CREB3L2/ATP2B1/ATP2B4/GNAQ/ATP1B1	-0.382238206992355
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/564	20/9376	0.831205673758865	DHCR24	-0.191168213500352
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	21/564	388/9376	0.899758719017328	LRP1/APOE/APP/LRP5/MME/GNAQ/SLC39A10/DVL3/PSEN2/RTN4/ADAM10/CTNNB1/KRAS/CASP3/FZD3/PIK3CB/NCSTN/FZD5/SLC11A2/ATP2A2/PSEN1	-0.510174661200035
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/564	100/9376	0.831205673758865	ITGA6/CSF3R/MME/IL4R/TFRC	-0.429304479796536
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/564	42/9376	0.791624451198919	AOC1/HADHA	-0.342393451187503
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/564	62/9376	0.804392587508579	IGF1R/KRAS/PIK3CB	-0.390931784673512
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/564	82/9376	0.810932364642795	CANX/LGMN/CTSL/HSPA5	-0.435021509108668
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/564	22/9376	0.755641521598968	AOC1	-0.290287286474041
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/564	44/9376	0.755641521598968	CREB3L2/DYNC1H1	-0.411011838609353
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/564	65/9376	0.767266775777414	GNAQ/KRAS/PIK3CB	-0.476326613331372
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	7/564	142/9376	0.819498551593247	IFNGR1/TGFBR2/PIK3CB/BTK/FOSL2/TAB1/ATP2A2	-0.548299530775621
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/564	23/9376	0.722787542399013	ATP1B1	-0.336735682977535
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	5/564	105/9376	0.791624451198919	KRAS/RPS27A/SP1/SMURF2/BCL2L1	-0.543207880272562
NA	NA	hsa04082	Neuroactive ligand signaling	10/564	199/9376	0.835382586692327	ADRB1/GABRE/SLC6A4/GNAQ/SLC1A3/TAC3/P2RX4/P2RY1/P2RY6/SLC6A2	-0.593799587392501
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	7/564	144/9376	0.808116627265563	TCF7L2/CTNNB1/ACACA/CASP3/LPIN1/CCND1/TAB1	-0.587027757880841
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	6/564	128/9376	0.779255319148936	PDE10A/ENTPD4/PDE7A/AMPD2/PDE5A/RRM2B	-0.63614961354604
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/564	69/9376	0.722787542399013	ADRB1/GNAQ/EDN1	-0.584682879870849
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/564	48/9376	0.692671394799054	ATP1B1/PIK3CB	-0.540029246759523
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	15/564	298/9376	0.836784235327717	IL6ST/CSF3R/LIFR/PRLR/IFNGR1/CSH1/BMPR1A/BMPR2/TNFSF4/ACVR2B/BMP7/TGFBR2/ACVR2A/IL4R/TGFB3	-0.724374398753881
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/564	26/9376	0.639388979814512	HHEX	-0.465808928828992
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/564	27/9376	0.615707906488048	HADHA	-0.505881383316442
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/564	28/9376	0.593718338399189	ATP6V1B1	-0.5446717236853
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/564	94/9376	0.707409084050098	HSP90B1/USP25/CASP3/MAPK6	-0.721260135621418
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	9/564	193/9376	0.77521772682174	GNAQ/ROCK2/KRAS/PTK2/SOS1/PIK3CB/VAV3/STAT3/ROCK1	-0.798245294489495
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/564	115/9376	0.722787542399013	APP/SLC6A4/GNAQ/KRAS/CASP3	-0.756694656392395
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/564	95/9376	0.699962672639044	FLT1/CTSL/ATP6V1B1/TGFB3	-0.743579915125987
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/564	75/9376	0.664964539007092	MTR/ALDH18A1/PC	-0.736961044387252
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/564	30/9376	0.554137115839243	PC	-0.618781051300251
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/564	31/9376	0.536261725005719	HADHA	-0.654262580475374
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	8/564	180/9376	0.738849487785658	IFNGR1/SRSF6/TLR3/CASP3/PIK3CB/MAVS/BCL2L1/TAB1	-0.894984675669243
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/564	78/9376	0.639388979814512	INPPL1/PIK3CB/IP6K2	-0.809057654114451
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/564	78/9376	0.639388979814512	DHX36/DCP2/TOB2	-0.809057654114451
Human Diseases	Immune disease	hsa05310	Asthma	1/564	32/9376	0.519503546099291	PRG2	-0.688789799859039
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/564	33/9376	0.503761014399312	STX7	-0.722424759191218
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	6/564	144/9376	0.692671394799054	VLDLR/PUM2/GNAQ/SP1/PIK3CB/ATP2A2	-0.940208729254736
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	9/564	205/9376	0.729839128178516	TGFBR2/SMAD2/SLC2A1/COL1A2/SP1/PIK3CB/COL3A1/ATP2A2/TGFB3	-0.989416113332972
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/564	59/9376	0.563529270344993	ENTPD4/RRM2B	-0.850806949551123
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/564	59/9376	0.563529270344993	GPX8/RRM2B	-0.850806949551123
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/564	59/9376	0.563529270344993	ADRB1/PIK3CB	-0.850806949551123
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/564	34/9376	0.488944513975803	POLR2J3	-0.755223556323784
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	10/564	227/9376	0.732339800668604	SLC26A2/EGFR/MET/AHR/NFE2L2/ABL2/KRAS/PTK2/SOS1/PIK3CB	-1.03275631158611
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/564	85/9376	0.586733416770964	ENTPD4/AMPD2/RRM2B	-0.968269982406261
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/564	37/9376	0.449300364193981	ALDH4A1	-0.849089381143843
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/564	37/9376	0.449300364193981	GNAQ	-0.849089381143843
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	11/564	253/9376	0.722787542399013	EGFR/ITGB1/ROCK2/RPS6KA5/RPS27A/PTK2/PIK3CB/BCL2L1/ROCK1/TAB1/WASL	-1.13081643598675
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	9/564	214/9376	0.699144959236429	GNAQ/CUL5/KRAS/CASP3/PTK2/PIK3CB/AP1G1/BCL2L1/TAB1	-1.12630751361705
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/564	110/9376	0.604513217279175	IGF1R/CPEB2/KRAS/PIK3CB	-1.05552886548304
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/564	38/9376	0.437476670399403	BTK	-0.879009053468699
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/564	89/9376	0.560363375567774	GABRE/SLC38A2/SLC38A1	-1.05423903132682
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/564	91/9376	0.548047696983867	GABRE/PDE10A/PDE7A	-1.09599933804671
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/564	67/9376	0.496242193288875	GNAQ/KRAS	-1.04687691124494
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/564	115/9376	0.578230033919211	CREB3L2/GNAQ/KRAS/PIK3CB	-1.15128693104952
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/564	41/9376	0.405466182321398	GLDC	-0.965159913731086
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/564	41/9376	0.405466182321398	GABRE	-0.965159913731086
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/564	116/9376	0.573245292247493	SLC38A2/GNAQ/SLC1A3/SLC38A1	-1.17001052349826
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/564	70/9376	0.474974670719352	SLC2A1/STAT3	-1.11541298974609
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/564	43/9376	0.386607290120402	HADHA	-1.01988252605014
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	8/564	205/9376	0.648745891714236	CDK6/CASP3/PIK3CB/MAVS/BTK/STAT3/CCND1/TAB1	-1.28640565996538
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/564	44/9376	0.377820760799484	GTF2I	-1.04650771572038
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/564	72/9376	0.461780929866036	MAP3K1/MAVS	-1.15978750323647
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	6/564	168/9376	0.593718338399189	IFNGR1/SMPD1/TLR3/TRPM7/CFLAR/STAT3	-1.34427199597256
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/564	47/9376	0.353704542025049	PIK3CB	-1.12370013279572
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/564	48/9376	0.346335697399527	HADHA	-1.14860066714622
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/564	49/9376	0.339267621942394	CREB3L2	-1.17311499690049
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/564	78/9376	0.426259319876341	ITGB1/CASP3	-1.28722990354568
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	6/564	173/9376	0.57655884885008	CDK6/IFNGR1/TLR3/CASP3/PIK3CB/MAVS	-1.42213016415713
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/564	105/9376	0.474974670719352	KRAS/CLEC1B/PIK3CB	-1.36867256186665
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/564	51/9376	0.325963009317202	PLPP3	-1.22104689820136
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/564	52/9376	0.319694489907256	IGF1R	-1.2444930450502
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/564	109/9376	0.457544407573687	TLR3/PIK3CB/TAB1	-1.44110559503775
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/564	83/9376	0.400581047594634	CASP3/MAVS	-1.38764857458631
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/564	86/9376	0.386607290120402	P2RY1/KCNK5	-1.44566585868126
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/564	56/9376	0.296859169199595	CASP3	-1.33510776282051
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/564	138/9376	0.481858361599342	IGF1R/SLK/CPEB2/YWHAZ	-1.5512686086911
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/564	187/9376	0.533394015246331	ANTXR2/PKN2/TRPM7/MAVS/BCL2L1/TAB1	-1.63051548731951
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/564	116/9376	0.42993396918562	GLDC/ACSS1/PC	-1.56291950158994
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/564	63/9376	0.263874817066306	PTGES	-1.48308176268052
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/564	63/9376	0.263874817066306	POLR2J3	-1.48308176268052
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/564	97/9376	0.342765226292316	GNAQ/RPS6KA5	-1.64605279007347
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/564	66/9376	0.251880507199656	STS	-1.54296489046925
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/564	67/9376	0.248121096644437	ACSS1	-1.56250613586316
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/564	99/9376	0.335840676266208	GNAQ/PIK3CB	-1.68063745768085
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/564	68/9376	0.244472256987902	RDH10	-1.58184756849416
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/564	69/9376	0.240929180799671	CREB3L2	-1.60099483420327
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	5/564	181/9376	0.459229654010423	EEA1/IFNGR1/CASP3/TGFB3/PLA2R1	-1.85850714447764
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/564	133/9376	0.374980003199488	CREB3L2/GNAQ/PPP2R3A	-1.83654342736833
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/564	370/9376	0.584090473452176	ADRB1/GABRE/PRLR/F2R/CSH1/EDN1/THRB/TAC3/NR3C1/P2RX4/P2RY1/P2RY6/EDNRB	-2.06500783988765
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/564	191/9376	0.435186216627678	CREB3L2/KRAS/SOS1/HDAC5/SLC29A3	-1.99512603401825
Cellular Processes	Cell motility	hsa04814	Motor proteins	5/564	194/9376	0.428456532865394	MYO6/DYNC1H1/HOOK3/KIFAP3/MYH10	-2.03502351411014
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	8/564	268/9376	0.496242193288875	SLC39A10/NFE2L2/CASP3/RPS27A/HSPA5/BCL2L1/GPR37/SLC11A2	-2.11673076239147
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/564	82/9376	0.202733091160699	RRM2B	-1.83441366466775
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/564	83/9376	0.200290523797317	SLC27A2	-1.85131903201045
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	17/564	480/9376	0.588770685579196	APP/LRP5/GNAQ/DVL3/GPX8/PSEN2/CTNNB1/KRAS/CASP3/RPS27A/FZD3/HSPA5/FZD5/BCL2L1/GPR37/ATP2A2/PSEN1	-2.33988893241844
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	9/564	308/9376	0.485769549599337	CREB3L2/POLR2J3/GNAQ/SLC1A3/CLTC/GPX8/CASP3/SP1/RCOR1	-2.3214820954561
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/564	100/9376	0.166241134751773	IL6ST	-2.12054767415465
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	5/564	235/9376	0.353704542025049	CREB3L2/SMARCA2/ARID1A/KRAS/SOS1	-2.53837701411198
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	2/564	149/9376	0.223142462754058	GABRE/GNAQ	-2.41819992614752
Genetic Information Processing	Transcription	hsa03040	Spliceosome	5/564	243/9376	0.342059948048916	SF1/THOC2/SF3B1/SRSF6/RBM25	-2.62887949339625
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	2/564	157/9376	0.211772146180603	CASP3/PIK3CB	-2.51969307420153
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/564	195/9376	0.255755591925805	CLCN5/PIK3CB/HDAC5	-2.65690385027816
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/564	138/9376	0.120464590399836	ATP6V1B1	-2.63324845954567
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	5/564	275/9376	0.302256608639587	LAMC1/CREB3L2/CASP3/PIK3CB/HSPA5	-2.971019261957
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	8/564	368/9376	0.361393771199507	GPX8/SETX/CASP3/NUP58/RANBP2/NUP210/HSPA5/BCL2L1	-3.16177394848868
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/564	154/9376	0.107948788799853	TPK1	-2.82374538836786