ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0019838 growth factor binding 30/993 136/18639 0.220588235294118 4.14052781233339 2.13949389108459e-11 2.3042349206981e-08 GO:0019199 transmembrane receptor protein kinase activity 20/993 78/18639 0.256410256410256 4.81292121775505 2.91787440829238e-09 1.15679277538374e-06 GO:0045296 cadherin binding 46/993 334/18639 0.137724550898204 2.58514391157263 3.22226399828339e-09 1.15679277538374e-06 GO:0005201 extracellular matrix structural constituent 30/993 168/18639 0.178571428571429 3.35185584807941 4.74415348783648e-09 1.27736332659997e-06 GO:0005178 integrin binding 28/993 161/18639 0.173913043478261 3.26441613030343 2.79457035022576e-08 6.01950453438629e-06 GO:0050840 extracellular matrix binding 17/993 67/18639 0.253731343283582 4.76263696622627 5.28683931157946e-08 9.48987656428512e-06 GO:0005518 collagen binding 16/993 72/18639 0.222222222222222 4.17119838872105 9.17568886341195e-07 0.000141174527227067 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 17/993 91/18639 0.186813186813187 3.50655688722154 5.38609627168875e-06 0.0006508661175166 GO:0003779 actin binding 47/993 443/18639 0.106094808126411 1.99144121718849 5.43899262548691e-06 0.0006508661175166 GO:0005024 transforming growth factor beta receptor activity 7/993 16/18639 0.4375 8.21204682779456 8.92574882327616e-06 0.000961303148266842 GO:0015291 secondary active transmembrane transporter activity 34/993 287/18639 0.118466898954704 2.22367022116488 1.09687137649529e-05 0.00106478013723122 GO:0043236 laminin binding 9/993 29/18639 0.310344827586207 5.82529430148974 1.26877197488745e-05 0.00106478013723122 GO:0004714 transmembrane receptor protein tyrosine kinase activity 13/993 60/18639 0.216666666666667 4.06691842900302 1.28524993351958e-05 0.00106478013723122 GO:0046332 SMAD binding 15/993 79/18639 0.189873417721519 3.56399862327431 1.55183248772297e-05 0.00119380256376974 GO:0016758 hexosyltransferase activity 26/993 197/18639 0.131979695431472 2.47731071817443 1.80541488394028e-05 0.00129628788666912 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 7/993 18/18639 0.388888888888889 7.29959718026183 2.25992396696314e-05 0.00152121132026206 GO:0022804 active transmembrane transporter activity 46/993 457/18639 0.100656455142232 1.88936119576643 2.63228776638169e-05 0.00158515518836886 GO:0017154 semaphorin receptor activity 6/993 13/18639 0.461538461538462 8.6632581919591 2.79646690612891e-05 0.00158515518836886 GO:0070123 transforming growth factor beta receptor activity, type III 6/993 13/18639 0.461538461538462 8.6632581919591 2.79646690612891e-05 0.00158515518836886 GO:0008201 heparin binding 23/993 172/18639 0.133720930232558 2.50999437925947 4.38152677679898e-05 0.00235945216930625 GO:0031267 small GTPase binding 32/993 283/18639 0.113074204946996 2.12244723666371 4.96580553973849e-05 0.00254674884109445 GO:0004713 protein tyrosine kinase activity 20/993 140/18639 0.142857142857143 2.68148467846353 5.29169886059221e-05 0.00259052712402628 GO:0003735 structural constituent of ribosome 23/993 175/18639 0.131428571428571 2.46696590418645 5.75979764301148e-05 0.00264123265615167 GO:0016798 hydrolase activity, acting on glycosyl bonds 19/993 130/18639 0.146153846153846 2.74336509412038 5.88575522262211e-05 0.00264123265615167 GO:0008375 acetylglucosaminyltransferase activity 10/993 43/18639 0.232558139534884 4.36520761610342 6.75160793150224e-05 0.00284099683024028 GO:1901681 sulfur compound binding 31/993 275/18639 0.112727272727273 2.11593518264213 6.858488169568e-05 0.00284099683024028 GO:0051020 GTPase binding 34/993 315/18639 0.107936507936508 2.02601064595022 7.49166335686181e-05 0.00298834127234821 GO:0030020 extracellular matrix structural constituent conferring tensile strength 10/993 44/18639 0.227272727272727 4.26599835210107 8.3241036850955e-05 0.00313548469903799 GO:0015924 mannosyl-oligosaccharide mannosidase activity 5/993 10/18639 0.5 9.38519637462236 8.55097201505661e-05 0.00313548469903799 GO:0015101 organic cation transmembrane transporter activity 14/993 81/18639 0.172839506172839 3.2442654134497 8.73394066584397e-05 0.00313548469903799 GO:0005539 glycosaminoglycan binding 28/993 242/18639 0.115702479338843 2.17178097925145 9.65892641951512e-05 0.00335569798510251 GO:0015923 mannosidase activity 6/993 16/18639 0.375 7.03889728096677 0.000113647569067009 0.00382495099641151 GO:0038024 cargo receptor activity 12/993 65/18639 0.184615384615385 3.46530327678364 0.000143802716670897 0.00469319775316835 GO:0016757 glycosyltransferase activity 29/993 267/18639 0.108614232209738 2.03873179673444 0.000221306959605315 0.00630426684366497 GO:0019955 cytokine binding 19/993 144/18639 0.131944444444444 2.47664904330312 0.000234279494203156 0.00630426684366497 GO:0005025 transforming growth factor beta receptor activity, type I 5/993 12/18639 0.416666666666667 7.82099697885196 0.000245683575740541 0.00630426684366497 GO:0005026 transforming growth factor beta receptor activity, type II 5/993 12/18639 0.416666666666667 7.82099697885196 0.000245683575740541 0.00630426684366497 GO:0016361 activin receptor activity, type I 5/993 12/18639 0.416666666666667 7.82099697885196 0.000245683575740541 0.00630426684366497 GO:0016362 activin receptor activity, type II 5/993 12/18639 0.416666666666667 7.82099697885196 0.000245683575740541 0.00630426684366497 GO:0017002 activin receptor activity 5/993 12/18639 0.416666666666667 7.82099697885196 0.000245683575740541 0.00630426684366497 GO:0015662 P-type ion transporter activity 7/993 25/18639 0.28 5.25570996978852 0.000245848846271057 0.00630426684366497 GO:0140358 P-type transmembrane transporter activity 7/993 25/18639 0.28 5.25570996978852 0.000245848846271057 0.00630426684366497 GO:0005021 vascular endothelial growth factor receptor activity 10/993 51/18639 0.196078431372549 3.68046916651857 0.000305574095467123 0.00765356513530445 GO:0001618 virus receptor activity 13/993 81/18639 0.160493827160494 3.01253216963187 0.000331534908959417 0.00802889209852699 GO:0005520 insulin-like growth factor binding 6/993 19/18639 0.315789473684211 5.92749244712991 0.000335469029186364 0.00802889209852699 GO:0140272 exogenous protein binding 13/993 82/18639 0.158536585365854 2.97579397244124 0.000375113201701486 0.00856569271106321 GO:0031994 insulin-like growth factor I binding 5/993 13/18639 0.384615384615385 7.21938182663258 0.000381757892415073 0.00856569271106321 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 5/993 13/18639 0.384615384615385 7.21938182663258 0.000381757892415073 0.00856569271106321 GO:0015294 solute:monoatomic cation symporter activity 16/993 116/18639 0.137931034482759 2.58901968955099 0.000430560102816998 0.00946353532110015 GO:0046915 transition metal ion transmembrane transporter activity 9/993 45/18639 0.2 3.75407854984894 0.000520840577804218 0.0111167677305653 GO:0045499 chemorepellent activity 7/993 28/18639 0.25 4.69259818731118 0.000526420756043483 0.0111167677305653 GO:0098821 BMP receptor activity 5/993 14/18639 0.357142857142857 6.70371169615883 0.000567883764061458 0.0117617464210421 GO:0003712 transcription coregulator activity 44/993 495/18639 0.0888888888888889 1.66847935548842 0.000627834260712551 0.0127580660148569 GO:0008194 UDP-glycosyltransferase activity 18/993 145/18639 0.124137931034483 2.3301177205959 0.000710855552218001 0.0141776190692368 GO:0004559 alpha-mannosidase activity 5/993 15/18639 0.333333333333333 6.25679758308157 0.000814637202854385 0.0156672190620388 GO:0005041 low-density lipoprotein particle receptor activity 5/993 15/18639 0.333333333333333 6.25679758308157 0.000814637202854385 0.0156672190620388 GO:0002020 protease binding 17/993 136/18639 0.125 2.34629909365559 0.000913303510112884 0.017256629480554 GO:0046873 metal ion transmembrane transporter activity 40/993 450/18639 0.0888888888888889 1.66847935548842 0.00108614041147659 0.0201685038475911 GO:0140327 flippase activity 5/993 16/18639 0.3125 5.86574773413897 0.00113326885457592 0.0206869585826824 GO:0005006 epidermal growth factor receptor activity 9/993 50/18639 0.18 3.37867069486405 0.00116015733357408 0.0208248241376548 GO:0030215 semaphorin receptor binding 6/993 24/18639 0.25 4.69259818731118 0.00132393208554279 0.0226049226762875 GO:0050431 transforming growth factor beta binding 6/993 24/18639 0.25 4.69259818731118 0.00132393208554279 0.0226049226762875 GO:0005010 insulin-like growth factor receptor activity 9/993 51/18639 0.176470588235294 3.31242224986671 0.00134328231316843 0.0226049226762875 GO:0005030 neurotrophin receptor activity 9/993 51/18639 0.176470588235294 3.31242224986671 0.00134328231316843 0.0226049226762875 GO:0030165 PDZ domain binding 12/993 83/18639 0.144578313253012 2.71379172278237 0.00143619642197435 0.0237966699456366 GO:0005003 ephrin receptor activity 9/993 53/18639 0.169811320754717 3.18742518383401 0.00177920623455783 0.0286000763375938 GO:0005005 transmembrane-ephrin receptor activity 9/993 53/18639 0.169811320754717 3.18742518383401 0.00177920623455783 0.0286000763375938 GO:0090482 vitamin transmembrane transporter activity 7/993 34/18639 0.205882352941176 3.8644926248445 0.00180950595602918 0.0286593810976974 GO:0002162 dystroglycan binding 4/993 11/18639 0.363636363636364 6.82559736336171 0.00195424865608871 0.0288318603096924 GO:0048185 activin binding 4/993 11/18639 0.363636363636364 6.82559736336171 0.00195424865608871 0.0288318603096924 GO:0048407 platelet-derived growth factor binding 4/993 11/18639 0.363636363636364 6.82559736336171 0.00195424865608871 0.0288318603096924 GO:0050998 nitric-oxide synthase binding 4/993 11/18639 0.363636363636364 6.82559736336171 0.00195424865608871 0.0288318603096924 GO:0097493 structural molecule activity conferring elasticity 4/993 11/18639 0.363636363636364 6.82559736336171 0.00195424865608871 0.0288318603096924 GO:0015293 symporter activity 17/993 146/18639 0.116438356164384 2.18559367628192 0.0020010990252932 0.0291241033816321 GO:0030228 lipoprotein particle receptor activity 5/993 18/18639 0.277777777777778 5.21399798590131 0.00203374890593195 0.0292046342891829 GO:0070006 metalloaminopeptidase activity 6/993 26/18639 0.230769230769231 4.33162909597955 0.00206737349052559 0.0292968585433692 GO:0098631 cell adhesion mediator activity 11/993 76/18639 0.144736842105263 2.71676737160121 0.00221497764947839 0.0308042176889744 GO:0015297 antiporter activity 16/993 135/18639 0.118518518518519 2.22463914065123 0.0022309461278923 0.0308042176889744 GO:0140303 intramembrane lipid transporter activity 8/993 45/18639 0.177777777777778 3.33695871097684 0.00234242561420166 0.0319340808417113 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 6/993 27/18639 0.222222222222222 4.17119838872105 0.0025398607401229 0.0341928752139045 GO:0016500 protein-hormone receptor activity 10/993 67/18639 0.149253731343284 2.80155115660369 0.00274929144130705 0.0365553936084901 GO:0003714 transcription corepressor activity 21/993 204/18639 0.102941176470588 1.93224631242225 0.00298040700041109 0.0391084953240978 GO:0043394 proteoglycan binding 7/993 37/18639 0.189189189189189 3.55115538499224 0.00301393232302704 0.0391084953240978 GO:0005516 calmodulin binding 21/993 207/18639 0.101449275362319 1.904242742677 0.00354250772307591 0.0454200097351519 GO:0046975 histone H3K36 methyltransferase activity 4/993 13/18639 0.307692307692308 5.77550546130607 0.00388709710908401 0.045583519073568 GO:0051015 actin filament binding 21/993 209/18639 0.100478468899522 1.88602032408679 0.00396439662302675 0.045583519073568 GO:0005004 GPI-linked ephrin receptor activity 8/993 49/18639 0.163265306122449 3.06455391824403 0.00406315490349353 0.045583519073568 GO:0005008 hepatocyte growth factor receptor activity 8/993 49/18639 0.163265306122449 3.06455391824403 0.00406315490349353 0.045583519073568 GO:0005009 insulin receptor activity 8/993 49/18639 0.163265306122449 3.06455391824403 0.00406315490349353 0.045583519073568 GO:0005011 macrophage colony-stimulating factor receptor activity 8/993 49/18639 0.163265306122449 3.06455391824403 0.00406315490349353 0.045583519073568 GO:0005018 platelet-derived growth factor alpha-receptor activity 8/993 49/18639 0.163265306122449 3.06455391824403 0.00406315490349353 0.045583519073568 GO:0005020 stem cell factor receptor activity 8/993 49/18639 0.163265306122449 3.06455391824403 0.00406315490349353 0.045583519073568 GO:0008288 boss receptor activity 8/993 49/18639 0.163265306122449 3.06455391824403 0.00406315490349353 0.045583519073568 GO:0036332 placental growth factor receptor activity 8/993 49/18639 0.163265306122449 3.06455391824403 0.00406315490349353 0.045583519073568 GO:0038062 protein tyrosine kinase collagen receptor activity 8/993 49/18639 0.163265306122449 3.06455391824403 0.00406315490349353 0.045583519073568 GO:0060175 brain-derived neurotrophic factor receptor activity 8/993 49/18639 0.163265306122449 3.06455391824403 0.00406315490349353 0.045583519073568 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 9/993 60/18639 0.15 2.81555891238671 0.00425928254035057 0.0472912092366759 GO:0001968 fibronectin binding 6/993 30/18639 0.2 3.75407854984894 0.0044463789566976 0.0488647973098298 GO:0005007 fibroblast growth factor receptor activity 8/993 50/18639 0.16 3.00326283987915 0.00461610682157342 0.049223238087471 GO:0005017 platelet-derived growth factor receptor activity 8/993 50/18639 0.16 3.00326283987915 0.00461610682157342 0.049223238087471 GO:0005019 platelet-derived growth factor beta-receptor activity 8/993 50/18639 0.16 3.00326283987915 0.00461610682157342 0.049223238087471 GO:0004177 aminopeptidase activity 7/993 40/18639 0.175 3.28481873111782 0.00475195530551262 0.0501750574905597 GO:0008514 organic anion transmembrane transporter activity 25/993 269/18639 0.0929368029739777 1.74446029268074 0.00497637715613152 0.0520345456034335 GO:0005545 1-phosphatidylinositol binding 4/993 14/18639 0.285714285714286 5.36296935692706 0.00521478244709303 0.0534887685287542 GO:0015926 glucosidase activity 4/993 14/18639 0.285714285714286 5.36296935692706 0.00521478244709303 0.0534887685287542 GO:0070325 lipoprotein particle receptor binding 6/993 31/18639 0.193548387096774 3.6329792417893 0.00526950408517518 0.0535401499974874 GO:0004674 protein serine/threonine kinase activity 36/993 433/18639 0.0831408775981524 1.5605869260342 0.00559495338597064 0.0563155588475737 GO:0019902 phosphatase binding 19/993 190/18639 0.1 1.87703927492447 0.00625697651845077 0.0610172802208221 GO:0048487 beta-tubulin binding 7/993 42/18639 0.166666666666667 3.12839879154079 0.00627139004437537 0.0610172802208221 GO:0016922 nuclear receptor binding 15/993 137/18639 0.109489051094891 2.05515249079322 0.00635733091013647 0.0610172802208221 GO:0005158 insulin receptor binding 5/993 23/18639 0.217391304347826 4.08052016287929 0.00640199876040194 0.0610172802208221 GO:0017134 fibroblast growth factor binding 5/993 23/18639 0.217391304347826 4.08052016287929 0.00640199876040194 0.0610172802208221 GO:0140103 catalytic activity, acting on a glycoprotein 5/993 23/18639 0.217391304347826 4.08052016287929 0.00640199876040194 0.0610172802208221 GO:0038064 collagen receptor activity 8/993 53/18639 0.150943396226415 2.83326683007467 0.00662477995246074 0.0625867369193002 GO:0015929 hexosaminidase activity 4/993 15/18639 0.266666666666667 5.00543806646526 0.00681483526317982 0.0628200422704321 GO:0048531 beta-1,3-galactosyltransferase activity 4/993 15/18639 0.266666666666667 5.00543806646526 0.00681483526317982 0.0628200422704321 GO:0005319 lipid transporter activity 18/993 178/18639 0.101123595505618 1.89812960385621 0.00683965136551761 0.0628200422704321 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 30/993 349/18639 0.0859598853868195 1.61350080939066 0.00688279014662116 0.0628200422704321 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 8/993 54/18639 0.148148148148148 2.78079892581403 0.00742282750586757 0.067179707763188 GO:0140297 DNA-binding transcription factor binding 39/993 488/18639 0.0799180327868853 1.50009286315685 0.00770086632074622 0.0691152752286973 GO:0008238 exopeptidase activity 12/993 102/18639 0.117647058823529 2.20828149991114 0.00798733889837891 0.0709360237629139 GO:0008235 metalloexopeptidase activity 9/993 66/18639 0.136363636363636 2.55959901126064 0.00803546415884447 0.0709360237629139 GO:0043014 alpha-tubulin binding 7/993 44/18639 0.159090909090909 2.98619884647075 0.00812584520508245 0.0711506933810878 GO:0005324 long-chain fatty acid transmembrane transporter activity 4/993 16/18639 0.25 4.69259818731118 0.00870869073271444 0.0756391928962375 GO:0015370 solute:sodium symporter activity 10/993 79/18639 0.126582278481013 2.37599908218288 0.00901697997996905 0.0776902995074133 GO:0000030 mannosyltransferase activity 5/993 25/18639 0.2 3.75407854984894 0.00925682026379893 0.0791237732072337 GO:0019903 protein phosphatase binding 15/993 144/18639 0.104166666666667 1.95524924471299 0.00992514674829375 0.0841683704560029 GO:0008013 beta-catenin binding 12/993 106/18639 0.113207547169811 2.12495012255601 0.0107337175862188 0.0903141706277943 GO:0050750 low-density lipoprotein particle receptor binding 5/993 26/18639 0.192307692307692 3.60969091331629 0.0109685933050545 0.0915749999189436 GO:0004190 aspartic-type endopeptidase activity 6/993 36/18639 0.166666666666667 3.12839879154079 0.0111261724464746 0.0921760594219475 GO:0046943 carboxylic acid transmembrane transporter activity 18/993 188/18639 0.0957446808510638 1.79716526322556 0.0117308976425955 0.0964440974127891 GO:0005342 organic acid transmembrane transporter activity 18/993 189/18639 0.0952380952380952 1.78765645230902 0.0123428424717432 0.100706373803541 GO:0004879 nuclear receptor activity 8/993 59/18639 0.135593220338983 2.54513799989759 0.012539538426684 0.101114021876669 GO:0019209 kinase activator activity 15/993 148/18639 0.101351351351351 1.90240467053156 0.0125805746810341 0.101114021876669 GO:0070001 aspartic-type peptidase activity 6/993 37/18639 0.162162162162162 3.04384747285049 0.0126962834381096 0.101288127872919 GO:0005044 scavenger receptor activity 5/993 27/18639 0.185185185185185 3.47599865726754 0.012884214342539 0.101338869138982 GO:0030695 GTPase regulator activity 38/993 489/18639 0.0777096114519427 1.45863992734417 0.0128908310789605 0.101338869138982 GO:0060589 nucleoside-triphosphatase regulator activity 38/993 490/18639 0.0775510204081633 1.45566311116592 0.0132840562494751 0.103673395512208 GO:0034185 apolipoprotein binding 4/993 18/18639 0.222222222222222 4.17119838872105 0.0134535342536423 0.104221992689533 GO:0005381 iron ion transmembrane transporter activity 3/993 10/18639 0.3 5.63111782477341 0.0136446619955656 0.104221992689533 GO:0031957 very long-chain fatty acid-CoA ligase activity 3/993 10/18639 0.3 5.63111782477341 0.0136446619955656 0.104221992689533 GO:0098531 ligand-modulated transcription factor activity 8/993 60/18639 0.133333333333333 2.50271903323263 0.0138134239476584 0.104768011208648 GO:0015081 sodium ion transmembrane transporter activity 16/993 164/18639 0.0975609756097561 1.83125782919461 0.0143033567718579 0.107725281421615 GO:0030246 carbohydrate binding 24/993 280/18639 0.0857142857142857 1.60889080707812 0.0150068331363905 0.111210148676504 GO:0097718 disordered domain specific binding 5/993 28/18639 0.178571428571429 3.35185584807941 0.0150136129527038 0.111210148676504 GO:0042626 ATPase-coupled transmembrane transporter activity 11/993 98/18639 0.112244897959184 2.10688081879277 0.0150972504721224 0.111210148676504 GO:0015026 coreceptor activity 8/993 61/18639 0.131147540983607 2.46169085235996 0.0151791010728376 0.111210148676504 GO:0015245 fatty acid transmembrane transporter activity 4/993 19/18639 0.210526315789474 3.95166163141994 0.0163370694057227 0.117300158333089 GO:0030506 ankyrin binding 4/993 19/18639 0.210526315789474 3.95166163141994 0.0163370694057227 0.117300158333089 GO:0042577 lipid phosphatase activity 4/993 19/18639 0.210526315789474 3.95166163141994 0.0163370694057227 0.117300158333089 GO:0048029 monosaccharide binding 9/993 74/18639 0.121621621621622 2.28288560463787 0.0164849111472578 0.117577809970838 GO:0015179 L-amino acid transmembrane transporter activity 8/993 62/18639 0.129032258064516 2.42198616119287 0.0166400164301699 0.117903274311138 GO:0008172 S-methyltransferase activity 3/993 11/18639 0.272727272727273 5.11919802252129 0.0180285669978694 0.124466452927598 GO:0008271 secondary active sulfate transmembrane transporter activity 3/993 11/18639 0.272727272727273 5.11919802252129 0.0180285669978694 0.124466452927598 GO:0034713 type I transforming growth factor beta receptor binding 3/993 11/18639 0.272727272727273 5.11919802252129 0.0180285669978694 0.124466452927598 GO:0047676 arachidonate-CoA ligase activity 3/993 11/18639 0.272727272727273 5.11919802252129 0.0180285669978694 0.124466452927598 GO:0005507 copper ion binding 8/993 63/18639 0.126984126984127 2.38354193641203 0.018199546272941 0.124846569018837 GO:0003713 transcription coactivator activity 22/993 256/18639 0.0859375 1.61308062688822 0.0187620471885074 0.127874310594132 GO:0005096 GTPase activator activity 23/993 271/18639 0.0848708487084871 1.59305916322003 0.0188783801155682 0.127874310594132 GO:0005326 neurotransmitter transmembrane transporter activity 4/993 20/18639 0.2 3.75407854984894 0.0195793913614834 0.130166694421714 GO:0016004 phospholipase activator activity 4/993 20/18639 0.2 3.75407854984894 0.0195793913614834 0.130166694421714 GO:0031418 L-ascorbic acid binding 4/993 20/18639 0.2 3.75407854984894 0.0195793913614834 0.130166694421714 GO:0035925 mRNA 3'-UTR AU-rich region binding 5/993 30/18639 0.166666666666667 3.12839879154079 0.0199499574140246 0.13181658978469 GO:0019208 phosphatase regulator activity 12/993 117/18639 0.102564102564103 1.92516848710202 0.0220683180858636 0.144655578543501 GO:0072349 modified amino acid transmembrane transporter activity 5/993 31/18639 0.161290322580645 3.02748270149108 0.0227731215157264 0.144655578543501 GO:0004300 enoyl-CoA hydratase activity 3/993 12/18639 0.25 4.69259818731118 0.0231019122650716 0.144655578543501 GO:0005095 GTPase inhibitor activity 3/993 12/18639 0.25 4.69259818731118 0.0231019122650716 0.144655578543501 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 3/993 12/18639 0.25 4.69259818731118 0.0231019122650716 0.144655578543501 GO:0008504 monoamine transmembrane transporter activity 3/993 12/18639 0.25 4.69259818731118 0.0231019122650716 0.144655578543501 GO:0017166 vinculin binding 3/993 12/18639 0.25 4.69259818731118 0.0231019122650716 0.144655578543501 GO:0031543 peptidyl-proline dioxygenase activity 3/993 12/18639 0.25 4.69259818731118 0.0231019122650716 0.144655578543501 GO:0045295 gamma-catenin binding 3/993 12/18639 0.25 4.69259818731118 0.0231019122650716 0.144655578543501 GO:0042393 histone binding 21/993 247/18639 0.0850202429149798 1.59586335115036 0.0236554909383832 0.147265686362074 GO:0004857 enzyme inhibitor activity 32/993 416/18639 0.0769230769230769 1.44387636532652 0.024025116776185 0.148707188321559 GO:0141003 histone H2AX kinase activity 28/993 354/18639 0.0790960451977401 1.48466383327359 0.0242335655636084 0.149140286354321 GO:0048156 tau protein binding 6/993 43/18639 0.13953488372093 2.61912456966205 0.0254602564385493 0.155799410138168 GO:0008378 galactosyltransferase activity 5/993 32/18639 0.15625 2.93287386706949 0.0258424280179707 0.15636120772671 GO:0042910 xenobiotic transmembrane transporter activity 5/993 32/18639 0.15625 2.93287386706949 0.0258424280179707 0.15636120772671 GO:0098632 cell-cell adhesion mediator activity 7/993 55/18639 0.127272727272727 2.3889590771766 0.0260496793068005 0.156734662644827 GO:0140996 histone H3 kinase activity 28/993 357/18639 0.0784313725490196 1.47218766660743 0.0266701776383159 0.159576562869257 GO:0015377 chloride:monoatomic cation symporter activity 4/993 22/18639 0.181818181818182 3.41279868168086 0.0271812859673255 0.16028122106491 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/993 22/18639 0.181818181818182 3.41279868168086 0.0271812859673255 0.16028122106491 GO:0019888 protein phosphatase regulator activity 11/993 107/18639 0.102803738317757 1.92966654431488 0.0272344136071296 0.16028122106491 GO:0008509 monoatomic anion transmembrane transporter activity 14/993 149/18639 0.0939597315436242 1.76366106368742 0.027998517792449 0.163882628600367 GO:0051011 microtubule minus-end binding 3/993 13/18639 0.230769230769231 4.33162909597955 0.0288663568118679 0.168049006953415 GO:0030296 protein tyrosine kinase activator activity 5/993 33/18639 0.151515151515152 2.84399890140071 0.0291639497962902 0.16870274229662 GO:0035173 histone kinase activity 28/993 360/18639 0.0777777777777778 1.45991943605237 0.0292919338992275 0.16870274229662 GO:0004867 serine-type endopeptidase inhibitor activity 10/993 95/18639 0.105263157894737 1.97583081570997 0.0297286063821922 0.170306963157559 GO:0015103 inorganic anion transmembrane transporter activity 15/993 165/18639 0.0909090909090909 1.70639934084043 0.0304513515688219 0.173524368463604 GO:0061134 peptidase regulator activity 19/993 226/18639 0.084070796460177 1.57804186829933 0.0334134813419503 0.189401681080423 GO:0019207 kinase regulator activity 23/993 287/18639 0.0801393728222996 1.50424750255271 0.0337647527484419 0.190390778586764 GO:0030295 protein kinase activator activity 13/993 139/18639 0.0935251798561151 1.75550435784303 0.0344867804484932 0.193077049341387 GO:0008195 phosphatidate phosphatase activity 3/993 14/18639 0.214285714285714 4.0222270176953 0.0353167861840792 0.193077049341387 GO:0015386 potassium:proton antiporter activity 3/993 14/18639 0.214285714285714 4.0222270176953 0.0353167861840792 0.193077049341387 GO:0042813 Wnt receptor activity 3/993 14/18639 0.214285714285714 4.0222270176953 0.0353167861840792 0.193077049341387 GO:0044548 S100 protein binding 3/993 14/18639 0.214285714285714 4.0222270176953 0.0353167861840792 0.193077049341387 GO:1901474 azole transmembrane transporter activity 3/993 14/18639 0.214285714285714 4.0222270176953 0.0353167861840792 0.193077049341387 GO:0048027 mRNA 5'-UTR binding 4/993 24/18639 0.166666666666667 3.12839879154079 0.0363193808780983 0.196562679425688 GO:0060229 lipase activator activity 4/993 24/18639 0.166666666666667 3.12839879154079 0.0363193808780983 0.196562679425688 GO:0140938 histone H3 methyltransferase activity 6/993 47/18639 0.127659574468085 2.39622035096741 0.0375454197789268 0.202182085509521 GO:0140693 molecular condensate scaffold activity 6/993 48/18639 0.125 2.34629909365559 0.0410520293585022 0.216791067779315 GO:0008139 nuclear localization sequence binding 4/993 25/18639 0.16 3.00326283987915 0.0414741543284411 0.216791067779315 GO:0015296 monoatomic anion:monoatomic cation symporter activity 4/993 25/18639 0.16 3.00326283987915 0.0414741543284411 0.216791067779315 GO:0015645 fatty acid ligase activity 4/993 25/18639 0.16 3.00326283987915 0.0414741543284411 0.216791067779315 GO:0120515 fatty acid-CoA ligase activity 4/993 25/18639 0.16 3.00326283987915 0.0414741543284411 0.216791067779315 GO:0033218 amide binding 20/993 247/18639 0.0809716599190283 1.51986985823844 0.0414893118869513 0.216791067779315 GO:0031406 carboxylic acid binding 16/993 187/18639 0.0855614973262032 1.60602290902629 0.0420104983499551 0.216791067779315 GO:0004467 long-chain fatty acid-CoA ligase activity 3/993 15/18639 0.2 3.75407854984894 0.042442273914304 0.216791067779315 GO:0015116 sulfate transmembrane transporter activity 3/993 15/18639 0.2 3.75407854984894 0.042442273914304 0.216791067779315 GO:0042809 nuclear vitamin D receptor binding 3/993 15/18639 0.2 3.75407854984894 0.042442273914304 0.216791067779315 GO:0001221 transcription coregulator binding 11/993 115/18639 0.0956521739130435 1.79542887166689 0.0428751136833743 0.216791067779315 GO:0035401 histone H3Y41 kinase activity 11/993 115/18639 0.0956521739130435 1.79542887166689 0.0428751136833743 0.216791067779315 GO:0140801 histone H2AXY142 kinase activity 11/993 115/18639 0.0956521739130435 1.79542887166689 0.0428751136833743 0.216791067779315 GO:0004175 endopeptidase activity 30/993 405/18639 0.0740740740740741 1.39039946290702 0.0431335261198196 0.21707854033199 GO:0004197 cysteine-type endopeptidase activity 9/993 88/18639 0.102272727272727 1.91969925844548 0.0444522266929138 0.22183492245001 GO:0042277 peptide binding 20/993 249/18639 0.0803212851405622 1.50766206821243 0.0444905694050159 0.22183492245001 GO:0001222 transcription corepressor binding 6/993 49/18639 0.122448979591837 2.29841543868303 0.0447585703352748 0.22214276613406 GO:0043177 organic acid binding 16/993 189/18639 0.0846560846560847 1.58902795760802 0.0455423668560609 0.224720115692034 GO:0003725 double-stranded RNA binding 8/993 75/18639 0.106666666666667 2.0021752265861 0.0456951767284637 0.224720115692034 GO:0005160 transforming growth factor beta receptor binding 4/993 26/18639 0.153846153846154 2.88775273065303 0.0470206199690567 0.230187307757609 GO:0106310 protein serine kinase activity 27/993 361/18639 0.074792243767313 1.40387979010972 0.0479618561180748 0.233732665335595 GO:0042887 amide transmembrane transporter activity 5/993 38/18639 0.131578947368421 2.46978851963746 0.0497073618192262 0.237840705295852 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 3/993 16/18639 0.1875 3.51944864048338 0.0502269469562093 0.237840705295852 GO:0015385 sodium:proton antiporter activity 3/993 16/18639 0.1875 3.51944864048338 0.0502269469562093 0.237840705295852 GO:0022858 alanine transmembrane transporter activity 3/993 16/18639 0.1875 3.51944864048338 0.0502269469562093 0.237840705295852 GO:0034450 ubiquitin-ubiquitin ligase activity 3/993 16/18639 0.1875 3.51944864048338 0.0502269469562093 0.237840705295852 GO:0140328 floppase activity 3/993 16/18639 0.1875 3.51944864048338 0.0502269469562093 0.237840705295852 GO:0015085 calcium ion transmembrane transporter activity 13/993 147/18639 0.0884353741496599 1.65996670571552 0.0503506785584533 0.237840705295852 GO:0005385 zinc ion transmembrane transporter activity 4/993 27/18639 0.148148148148148 2.78079892581403 0.052957386164973 0.247978716955113 GO:0016405 CoA-ligase activity 4/993 27/18639 0.148148148148148 2.78079892581403 0.052957386164973 0.247978716955113 GO:0019887 protein kinase regulator activity 20/993 255/18639 0.0784313725490196 1.47218766660743 0.0544318594627899 0.253779708404436 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/993 17/18639 0.176470588235294 3.31242224986671 0.0586507632661742 0.26670331393887 GO:0008484 sulfuric ester hydrolase activity 3/993 17/18639 0.176470588235294 3.31242224986671 0.0586507632661742 0.26670331393887 GO:0019198 transmembrane receptor protein phosphatase activity 3/993 17/18639 0.176470588235294 3.31242224986671 0.0586507632661742 0.26670331393887 GO:0038191 neuropilin binding 3/993 17/18639 0.176470588235294 3.31242224986671 0.0586507632661742 0.26670331393887 GO:1990226 histone methyltransferase binding 3/993 17/18639 0.176470588235294 3.31242224986671 0.0586507632661742 0.26670331393887 GO:0044325 transmembrane transporter binding 12/993 136/18639 0.0882352941176471 1.65621112493336 0.0592696708524872 0.26670331393887 GO:0046875 ephrin receptor binding 4/993 28/18639 0.142857142857143 2.68148467846353 0.0592813483670177 0.26670331393887 GO:0046966 nuclear thyroid hormone receptor binding 4/993 28/18639 0.142857142857143 2.68148467846353 0.0592813483670177 0.26670331393887 GO:0051213 dioxygenase activity 9/993 93/18639 0.0967741935483871 1.81648962089465 0.0594324933568512 0.26670331393887 GO:0030331 nuclear estrogen receptor binding 5/993 40/18639 0.125 2.34629909365559 0.0598067768217029 0.2672692889501 GO:1901505 carbohydrate derivative transmembrane transporter activity 6/993 53/18639 0.113207547169811 2.12495012255601 0.0616194318096712 0.274231934128165 GO:0005496 steroid binding 10/993 108/18639 0.0925925925925926 1.73799932863377 0.062119077340633 0.275317885991201 GO:0042562 hormone binding 9/993 94/18639 0.0957446808510638 1.79716526322556 0.0627736649173918 0.277078840639471 GO:0015175 neutral L-amino acid transmembrane transporter activity 5/993 41/18639 0.121951219512195 2.28907228649326 0.0652619450667846 0.281326702599607 GO:0042169 SH2 domain binding 5/993 41/18639 0.121951219512195 2.28907228649326 0.0652619450667846 0.281326702599607 GO:0140318 protein transporter activity 5/993 41/18639 0.121951219512195 2.28907228649326 0.0652619450667846 0.281326702599607 GO:0003785 actin monomer binding 4/993 29/18639 0.137931034482759 2.58901968955099 0.0659877996783587 0.281326702599607 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 4/993 29/18639 0.137931034482759 2.58901968955099 0.0659877996783587 0.281326702599607 GO:0035250 UDP-galactosyltransferase activity 4/993 29/18639 0.137931034482759 2.58901968955099 0.0659877996783587 0.281326702599607 GO:0097472 cyclin-dependent protein kinase activity 4/993 29/18639 0.137931034482759 2.58901968955099 0.0659877996783587 0.281326702599607 GO:0106222 lncRNA binding 4/993 29/18639 0.137931034482759 2.58901968955099 0.0659877996783587 0.281326702599607 GO:0015485 cholesterol binding 6/993 54/18639 0.111111111111111 2.08559919436052 0.0663481731293409 0.281326702599607 GO:0140463 chromatin-protein adaptor activity 6/993 54/18639 0.111111111111111 2.08559919436052 0.0663481731293409 0.281326702599607 GO:0008237 metallopeptidase activity 15/993 184/18639 0.0815217391304348 1.53019506107973 0.0671326824208147 0.282567268089027 GO:0000900 mRNA regulatory element binding translation repressor activity 3/993 18/18639 0.166666666666667 3.12839879154079 0.0676902090686805 0.282567268089027 GO:0008525 phosphatidylcholine transporter activity 3/993 18/18639 0.166666666666667 3.12839879154079 0.0676902090686805 0.282567268089027 GO:0070064 proline-rich region binding 3/993 18/18639 0.166666666666667 3.12839879154079 0.0676902090686805 0.282567268089027 GO:0005548 phospholipid transporter activity 7/993 68/18639 0.102941176470588 1.93224631242225 0.0693425173112888 0.287238042862531 GO:0032934 sterol binding 7/993 68/18639 0.102941176470588 1.93224631242225 0.0693425173112888 0.287238042862531 GO:0008307 structural constituent of muscle 5/993 42/18639 0.119047619047619 2.23457056538627 0.0709857311533901 0.291800123863363 GO:0035198 miRNA binding 5/993 42/18639 0.119047619047619 2.23457056538627 0.0709857311533901 0.291800123863363 GO:0140313 molecular sequestering activity 6/993 55/18639 0.109090909090909 2.04767920900851 0.071282682576999 0.291906650705049 GO:0042826 histone deacetylase binding 11/993 127/18639 0.0866141732283465 1.62578204914718 0.0764055897080818 0.308416591880213 GO:0003756 protein disulfide isomerase activity 3/993 19/18639 0.157894736842105 2.96374622356495 0.0773189227554851 0.308416591880213 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 3/993 19/18639 0.157894736842105 2.96374622356495 0.0773189227554851 0.308416591880213 GO:0022821 solute:potassium antiporter activity 3/993 19/18639 0.157894736842105 2.96374622356495 0.0773189227554851 0.308416591880213 GO:0042800 histone H3K4 methyltransferase activity 3/993 19/18639 0.157894736842105 2.96374622356495 0.0773189227554851 0.308416591880213 GO:0043395 heparan sulfate proteoglycan binding 3/993 19/18639 0.157894736842105 2.96374622356495 0.0773189227554851 0.308416591880213 GO:0046624 sphingolipid transporter activity 3/993 19/18639 0.157894736842105 2.96374622356495 0.0773189227554851 0.308416591880213 GO:0097110 scaffold protein binding 7/993 70/18639 0.1 1.87703927492447 0.0784358379016996 0.310701497036919 GO:0051117 ATPase binding 8/993 84/18639 0.0952380952380952 1.78765645230902 0.0784687160576063 0.310701497036919 GO:0016878 acid-thiol ligase activity 4/993 31/18639 0.129032258064516 2.42198616119287 0.0805220147348988 0.316504415582066 GO:0017147 Wnt-protein binding 4/993 31/18639 0.129032258064516 2.42198616119287 0.0805220147348988 0.316504415582066 GO:0016504 peptidase activator activity 6/993 57/18639 0.105263157894737 1.97583081570997 0.0817661861369769 0.320226118070997 GO:0061980 regulatory RNA binding 6/993 58/18639 0.103448275862069 1.94176476716325 0.0873127039488344 0.334982587515359 GO:0001614 purinergic nucleotide receptor activity 3/993 20/18639 0.15 2.81555891238671 0.0875082518250148 0.334982587515359 GO:0015095 magnesium ion transmembrane transporter activity 3/993 20/18639 0.15 2.81555891238671 0.0875082518250148 0.334982587515359 GO:0016502 nucleotide receptor activity 3/993 20/18639 0.15 2.81555891238671 0.0875082518250148 0.334982587515359 GO:0061608 nuclear import signal receptor activity 3/993 20/18639 0.15 2.81555891238671 0.0875082518250148 0.334982587515359 GO:0071813 lipoprotein particle binding 4/993 32/18639 0.125 2.34629909365559 0.0883333842658886 0.334982587515359 GO:0071814 protein-lipid complex binding 4/993 32/18639 0.125 2.34629909365559 0.0883333842658886 0.334982587515359 GO:0120015 sterol transfer activity 4/993 32/18639 0.125 2.34629909365559 0.0883333842658886 0.334982587515359 GO:0140142 nucleocytoplasmic carrier activity 4/993 32/18639 0.125 2.34629909365559 0.0883333842658886 0.334982587515359 GO:0043539 protein serine/threonine kinase activator activity 7/993 73/18639 0.0958904109589041 1.79990067458511 0.0933120423776206 0.348317441324067 GO:0015171 amino acid transmembrane transporter activity 9/993 102/18639 0.0882352941176471 1.65621112493336 0.0937482923520076 0.348317441324067 GO:0005337 nucleoside transmembrane transporter activity 2/993 10/18639 0.2 3.75407854984894 0.0960541133456341 0.348317441324067 GO:0005345 purine nucleobase transmembrane transporter activity 2/993 10/18639 0.2 3.75407854984894 0.0960541133456341 0.348317441324067 GO:0008190 eukaryotic initiation factor 4E binding 2/993 10/18639 0.2 3.75407854984894 0.0960541133456341 0.348317441324067 GO:0008239 dipeptidyl-peptidase activity 2/993 10/18639 0.2 3.75407854984894 0.0960541133456341 0.348317441324067 GO:0015187 glycine transmembrane transporter activity 2/993 10/18639 0.2 3.75407854984894 0.0960541133456341 0.348317441324067 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/993 10/18639 0.2 3.75407854984894 0.0960541133456341 0.348317441324067 GO:0019911 structural constituent of myelin sheath 2/993 10/18639 0.2 3.75407854984894 0.0960541133456341 0.348317441324067 GO:0031419 cobalamin binding 2/993 10/18639 0.2 3.75407854984894 0.0960541133456341 0.348317441324067 GO:0045322 unmethylated CpG binding 2/993 10/18639 0.2 3.75407854984894 0.0960541133456341 0.348317441324067 GO:0140999 histone H3K4 trimethyltransferase activity 2/993 10/18639 0.2 3.75407854984894 0.0960541133456341 0.348317441324067 GO:1905394 retromer complex binding 2/993 10/18639 0.2 3.75407854984894 0.0960541133456341 0.348317441324067 GO:0030276 clathrin binding 5/993 46/18639 0.108695652173913 2.04026008143964 0.0965122813248313 0.348804452975984 GO:0015174 basic amino acid transmembrane transporter activity 3/993 21/18639 0.142857142857143 2.68148467846353 0.0982277487646249 0.350302269600997 GO:0036122 BMP binding 3/993 21/18639 0.142857142857143 2.68148467846353 0.0982277487646249 0.350302269600997 GO:0051010 microtubule plus-end binding 3/993 21/18639 0.142857142857143 2.68148467846353 0.0982277487646249 0.350302269600997 GO:0140312 cargo adaptor activity 3/993 21/18639 0.142857142857143 2.68148467846353 0.0982277487646249 0.350302269600997 GO:0035064 methylated histone binding 7/993 74/18639 0.0945945945945946 1.77557769249612 0.0985969491498446 0.350458462819745 GO:0043495 protein-membrane adaptor activity 5/993 47/18639 0.106382978723404 1.99685029247284 0.103532145794582 0.366789871778831 GO:0008376 acetylgalactosaminyltransferase activity 4/993 34/18639 0.117647058823529 2.20828149991114 0.104994922572014 0.368873858205409 GO:0015020 glucuronosyltransferase activity 4/993 34/18639 0.117647058823529 2.20828149991114 0.104994922572014 0.368873858205409 GO:0019905 syntaxin binding 6/993 61/18639 0.0983606557377049 1.84626813926997 0.105147887157902 0.368873858205409 GO:0008093 cytoskeletal anchor activity 3/993 22/18639 0.136363636363636 2.55959901126064 0.109445611311567 0.374614706030101 GO:0050321 tau-protein kinase activity 3/993 22/18639 0.136363636363636 2.55959901126064 0.109445611311567 0.374614706030101 GO:0140034 methylation-dependent protein binding 7/993 76/18639 0.0921052631578947 1.72885196374622 0.109647639905091 0.374614706030101 GO:0015108 chloride transmembrane transporter activity 10/993 121/18639 0.0826446280991736 1.55127212803675 0.111441555630863 0.374614706030101 GO:0004143 ATP-dependent diacylglycerol kinase activity 2/993 11/18639 0.181818181818182 3.41279868168086 0.113393123645137 0.374614706030101 GO:0005114 type II transforming growth factor beta receptor binding 2/993 11/18639 0.181818181818182 3.41279868168086 0.113393123645137 0.374614706030101 GO:0008046 axon guidance receptor activity 2/993 11/18639 0.181818181818182 3.41279868168086 0.113393123645137 0.374614706030101 GO:0008432 JUN kinase binding 2/993 11/18639 0.181818181818182 3.41279868168086 0.113393123645137 0.374614706030101 GO:0015205 nucleobase transmembrane transporter activity 2/993 11/18639 0.181818181818182 3.41279868168086 0.113393123645137 0.374614706030101 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/993 11/18639 0.181818181818182 3.41279868168086 0.113393123645137 0.374614706030101 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/993 11/18639 0.181818181818182 3.41279868168086 0.113393123645137 0.374614706030101 GO:0032050 clathrin heavy chain binding 2/993 11/18639 0.181818181818182 3.41279868168086 0.113393123645137 0.374614706030101 GO:0032794 GTPase activating protein binding 2/993 11/18639 0.181818181818182 3.41279868168086 0.113393123645137 0.374614706030101 GO:0034056 estrogen response element binding 2/993 11/18639 0.181818181818182 3.41279868168086 0.113393123645137 0.374614706030101 GO:0035252 UDP-xylosyltransferase activity 2/993 11/18639 0.181818181818182 3.41279868168086 0.113393123645137 0.374614706030101 GO:0042285 xylosyltransferase activity 2/993 11/18639 0.181818181818182 3.41279868168086 0.113393123645137 0.374614706030101 GO:0045294 alpha-catenin binding 2/993 11/18639 0.181818181818182 3.41279868168086 0.113393123645137 0.374614706030101 GO:0140537 transcription regulator activator activity 2/993 11/18639 0.181818181818182 3.41279868168086 0.113393123645137 0.374614706030101 GO:1990948 ubiquitin ligase inhibitor activity 2/993 11/18639 0.181818181818182 3.41279868168086 0.113393123645137 0.374614706030101 GO:0005343 organic acid:sodium symporter activity 4/993 35/18639 0.114285714285714 2.14518774277082 0.113822181893065 0.374882232106516 GO:0061135 endopeptidase regulator activity 14/993 184/18639 0.0760869565217391 1.42818205700775 0.114459941436622 0.375833405265982 GO:0030414 peptidase inhibitor activity 13/993 169/18639 0.0769230769230769 1.44387636532652 0.117475215430542 0.384561723461074 GO:1901682 sulfur compound transmembrane transporter activity 6/993 63/18639 0.0952380952380952 1.78765645230902 0.118007149455841 0.385132424133154 GO:0005283 amino acid:sodium symporter activity 3/993 23/18639 0.130434782608696 2.44831209772757 0.121129072096142 0.390586858226184 GO:0043274 phospholipase binding 3/993 23/18639 0.130434782608696 2.44831209772757 0.121129072096142 0.390586858226184 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 3/993 23/18639 0.130434782608696 2.44831209772757 0.121129072096142 0.390586858226184 GO:0070577 lysine-acetylated histone binding 3/993 23/18639 0.130434782608696 2.44831209772757 0.121129072096142 0.390586858226184 GO:0008234 cysteine-type peptidase activity 14/993 187/18639 0.0748663101604278 1.405270045398 0.125671110083143 0.404023240476255 GO:0031625 ubiquitin protein ligase binding 21/993 302/18639 0.0695364238410596 1.30522598587463 0.128886723789122 0.410013106928429 GO:0005078 MAP-kinase scaffold activity 2/993 12/18639 0.166666666666667 3.12839879154079 0.131451365921151 0.410013106928429 GO:0005247 voltage-gated chloride channel activity 2/993 12/18639 0.166666666666667 3.12839879154079 0.131451365921151 0.410013106928429 GO:0035497 cAMP response element binding 2/993 12/18639 0.166666666666667 3.12839879154079 0.131451365921151 0.410013106928429 GO:0070410 co-SMAD binding 2/993 12/18639 0.166666666666667 3.12839879154079 0.131451365921151 0.410013106928429 GO:0097371 MDM2/MDM4 family protein binding 2/993 12/18639 0.166666666666667 3.12839879154079 0.131451365921151 0.410013106928429 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/993 12/18639 0.166666666666667 3.12839879154079 0.131451365921151 0.410013106928429 GO:0004222 metalloendopeptidase activity 9/993 110/18639 0.0818181818181818 1.53575940675639 0.132222950690814 0.410013106928429 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 3/993 24/18639 0.125 2.34629909365559 0.133244742270149 0.410013106928429 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 3/993 24/18639 0.125 2.34629909365559 0.133244742270149 0.410013106928429 GO:0015149 hexose transmembrane transporter activity 3/993 24/18639 0.125 2.34629909365559 0.133244742270149 0.410013106928429 GO:0015295 solute:proton symporter activity 3/993 24/18639 0.125 2.34629909365559 0.133244742270149 0.410013106928429 GO:0035035 histone acetyltransferase binding 3/993 24/18639 0.125 2.34629909365559 0.133244742270149 0.410013106928429 GO:0055056 D-glucose transmembrane transporter activity 3/993 24/18639 0.125 2.34629909365559 0.133244742270149 0.410013106928429 GO:0140033 acetylation-dependent protein binding 3/993 24/18639 0.125 2.34629909365559 0.133244742270149 0.410013106928429 GO:0016597 amino acid binding 5/993 51/18639 0.0980392156862745 1.84023458325929 0.134001821521891 0.411167982276572 GO:0044389 ubiquitin-like protein ligase binding 22/993 322/18639 0.0683229813664596 1.28244919404778 0.139243463788475 0.426037529830077 GO:0005109 frizzled binding 4/993 38/18639 0.105263157894737 1.97583081570997 0.142135444056751 0.431355872542859 GO:0042162 telomeric DNA binding 4/993 38/18639 0.105263157894737 1.97583081570997 0.142135444056751 0.431355872542859 GO:0005080 protein kinase C binding 5/993 52/18639 0.0961538461538462 1.80484545665815 0.142183226325641 0.431355872542859 GO:0003707 nuclear steroid receptor activity 3/993 25/18639 0.12 2.25244712990937 0.145758913353109 0.435473853880741 GO:0005537 D-mannose binding 3/993 25/18639 0.12 2.25244712990937 0.145758913353109 0.435473853880741 GO:0017025 TBP-class protein binding 3/993 25/18639 0.12 2.25244712990937 0.145758913353109 0.435473853880741 GO:0120020 cholesterol transfer activity 3/993 25/18639 0.12 2.25244712990937 0.145758913353109 0.435473853880741 GO:0042054 histone methyltransferase activity 6/993 67/18639 0.0895522388059701 1.68093069396221 0.145922327643899 0.435473853880741 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/993 13/18639 0.153846153846154 2.88775273065303 0.150103185759202 0.435473853880741 GO:0005542 folic acid binding 2/993 13/18639 0.153846153846154 2.88775273065303 0.150103185759202 0.435473853880741 GO:0035673 oligopeptide transmembrane transporter activity 2/993 13/18639 0.153846153846154 2.88775273065303 0.150103185759202 0.435473853880741 GO:0043560 insulin receptor substrate binding 2/993 13/18639 0.153846153846154 2.88775273065303 0.150103185759202 0.435473853880741 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 2/993 13/18639 0.153846153846154 2.88775273065303 0.150103185759202 0.435473853880741 GO:0046974 histone H3K9 methyltransferase activity 2/993 13/18639 0.153846153846154 2.88775273065303 0.150103185759202 0.435473853880741 GO:0061459 L-arginine transmembrane transporter activity 2/993 13/18639 0.153846153846154 2.88775273065303 0.150103185759202 0.435473853880741 GO:0140333 glycerophospholipid flippase activity 2/993 13/18639 0.153846153846154 2.88775273065303 0.150103185759202 0.435473853880741 GO:0035591 signaling adaptor activity 10/993 129/18639 0.0775193798449612 1.45506920536781 0.150325052515865 0.435473853880741 GO:0017046 peptide hormone binding 5/993 53/18639 0.0943396226415094 1.77079176879667 0.150575288254388 0.435473853880741 GO:0051018 protein kinase A binding 5/993 53/18639 0.0943396226415094 1.77079176879667 0.150575288254388 0.435473853880741 GO:0004866 endopeptidase inhibitor activity 12/993 161/18639 0.0745341614906832 1.39903548441576 0.151227777360636 0.435473853880741 GO:0019787 ubiquitin-like protein transferase activity 31/993 479/18639 0.0647181628392484 1.21478533450227 0.152329868046192 0.435473853880741 GO:0001540 amyloid-beta binding 7/993 83/18639 0.0843373493975904 1.58304517162305 0.153144875015842 0.435473853880741 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 17/993 243/18639 0.0699588477366255 1.31315504830107 0.15320918804132 0.435473853880741 GO:0004112 cyclic-nucleotide phosphodiesterase activity 3/993 26/18639 0.115384615384615 2.16581454798977 0.158637821185811 0.435473853880741 GO:0005112 Notch binding 3/993 26/18639 0.115384615384615 2.16581454798977 0.158637821185811 0.435473853880741 GO:0015145 monosaccharide transmembrane transporter activity 3/993 26/18639 0.115384615384615 2.16581454798977 0.158637821185811 0.435473853880741 GO:0051139 metal cation:proton antiporter activity 3/993 26/18639 0.115384615384615 2.16581454798977 0.158637821185811 0.435473853880741 GO:0017124 SH3 domain binding 9/993 115/18639 0.0782608695652174 1.46898725863654 0.159882869945575 0.435473853880741 GO:0016279 protein-lysine N-methyltransferase activity 6/993 69/18639 0.0869565217391304 1.63220806515171 0.160907264732745 0.435473853880741 GO:0004676 3-phosphoinositide-dependent protein kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:0004711 ribosomal protein S6 kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:0035175 histone H3S10 kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:0035979 histone H2AXS139 kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:0044022 histone H3S28 kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:0044023 histone H4S1 kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:0044024 histone H2AS1 kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:0044025 histone H2BS14 kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:0072354 histone H3T3 kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:0072371 histone H2AS121 kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:0072518 Rho-dependent protein serine/threonine kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:0140823 histone H2BS36 kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:0140855 histone H3S57 kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:0140995 histone H2A kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:0140997 histone H4 kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:0140998 histone H2B kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:1990244 histone H2AT120 kinase activity 17/993 245/18639 0.0693877551020408 1.30243541525371 0.160927199484248 0.435473853880741 GO:0015144 carbohydrate transmembrane transporter activity 4/993 40/18639 0.1 1.87703927492447 0.162395931715813 0.438346913428397 GO:0004677 DNA-dependent protein kinase activity 17/993 246/18639 0.0691056910569106 1.29714096234618 0.164862770209287 0.442391480064066 GO:0140857 histone H3T45 kinase activity 17/993 246/18639 0.0691056910569106 1.29714096234618 0.164862770209287 0.442391480064066 GO:0016278 lysine N-methyltransferase activity 6/993 70/18639 0.0857142857142857 1.60889080707812 0.168638960998155 0.442391480064066 GO:0035402 histone H3T11 kinase activity 17/993 247/18639 0.0688259109311741 1.29188937950267 0.168848756250344 0.442391480064066 GO:0035403 histone H3T6 kinase activity 17/993 247/18639 0.0688259109311741 1.29188937950267 0.168848756250344 0.442391480064066 GO:0004065 arylsulfatase activity 2/993 14/18639 0.142857142857143 2.68148467846353 0.169234252355056 0.442391480064066 GO:0004705 JUN kinase activity 2/993 14/18639 0.142857142857143 2.68148467846353 0.169234252355056 0.442391480064066 GO:0005161 platelet-derived growth factor receptor binding 2/993 14/18639 0.142857142857143 2.68148467846353 0.169234252355056 0.442391480064066 GO:0031404 chloride ion binding 2/993 14/18639 0.142857142857143 2.68148467846353 0.169234252355056 0.442391480064066 GO:0042043 neurexin family protein binding 2/993 14/18639 0.142857142857143 2.68148467846353 0.169234252355056 0.442391480064066 GO:0061665 SUMO ligase activity 2/993 14/18639 0.142857142857143 2.68148467846353 0.169234252355056 0.442391480064066 GO:0071933 Arp2/3 complex binding 2/993 14/18639 0.142857142857143 2.68148467846353 0.169234252355056 0.442391480064066 GO:1901612 cardiolipin binding 2/993 14/18639 0.142857142857143 2.68148467846353 0.169234252355056 0.442391480064066 GO:1990782 protein tyrosine kinase binding 9/993 117/18639 0.0769230769230769 1.44387636532652 0.171670260204941 0.447620107681097 GO:0004679 AMP-activated protein kinase activity 17/993 248/18639 0.0685483870967742 1.28668014813371 0.172884654463215 0.447620107681097 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/993 41/18639 0.0975609756097561 1.83125782919461 0.172896903245438 0.447620107681097 GO:0016877 ligase activity, forming carbon-sulfur bonds 4/993 41/18639 0.0975609756097561 1.83125782919461 0.172896903245438 0.447620107681097 GO:0016209 antioxidant activity 7/993 86/18639 0.0813953488372093 1.5278226656362 0.173908465832073 0.449159275062693 GO:0019842 vitamin binding 11/993 150/18639 0.0733333333333333 1.37649546827795 0.176901370634377 0.454788966675009 GO:0170055 lipid transmembrane transporter activity 5/993 56/18639 0.0892857142857143 1.67592792403971 0.176932754908848 0.454788966675009 GO:0019894 kinesin binding 4/993 42/18639 0.0952380952380952 1.78765645230902 0.183624395044601 0.469454377115742 GO:0050698 proteoglycan sulfotransferase activity 3/993 28/18639 0.107142857142857 2.01111350884765 0.185355858826984 0.469454377115742 GO:0051119 sugar transmembrane transporter activity 3/993 28/18639 0.107142857142857 2.01111350884765 0.185355858826984 0.469454377115742 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 18/993 268/18639 0.0671641791044776 1.26069802047166 0.18596722017853 0.469454377115742 GO:0015932 nucleobase-containing compound transmembrane transporter activity 5/993 57/18639 0.087719298245614 1.64652567975831 0.186083386521527 0.469454377115742 GO:1901981 phosphatidylinositol phosphate binding 13/993 185/18639 0.0702702702702703 1.31900057156855 0.188502073889722 0.469454377115742 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/993 15/18639 0.133333333333333 2.50271903323263 0.18874071057671 0.469454377115742 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/993 15/18639 0.133333333333333 2.50271903323263 0.18874071057671 0.469454377115742 GO:0005402 carbohydrate:monoatomic cation symporter activity 2/993 15/18639 0.133333333333333 2.50271903323263 0.18874071057671 0.469454377115742 GO:0030553 cGMP binding 2/993 15/18639 0.133333333333333 2.50271903323263 0.18874071057671 0.469454377115742 GO:0031386 protein tag activity 2/993 15/18639 0.133333333333333 2.50271903323263 0.18874071057671 0.469454377115742 GO:0055105 ubiquitin-protein transferase inhibitor activity 2/993 15/18639 0.133333333333333 2.50271903323263 0.18874071057671 0.469454377115742 GO:0120283 protein serine/threonine kinase binding 2/993 15/18639 0.133333333333333 2.50271903323263 0.18874071057671 0.469454377115742 GO:0141047 molecular tag activity 2/993 15/18639 0.133333333333333 2.50271903323263 0.18874071057671 0.469454377115742 GO:0005416 amino acid:monoatomic cation symporter activity 3/993 29/18639 0.103448275862069 1.94176476716325 0.199129096421056 0.494152158630132 GO:0016755 aminoacyltransferase activity 31/993 496/18639 0.0625 1.17314954682779 0.201736830554581 0.499472566683411 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 5/993 59/18639 0.0847457627118644 1.59071124993599 0.20487742324622 0.506084827605915 GO:0001046 core promoter sequence-specific DNA binding 4/993 44/18639 0.0909090909090909 1.70639934084043 0.20569600969909 0.506944170356796 GO:0004707 MAP kinase activity 2/993 16/18639 0.125 2.34629909365559 0.208528391093924 0.508111034407593 GO:0015378 sodium:chloride symporter activity 2/993 16/18639 0.125 2.34629909365559 0.208528391093924 0.508111034407593 GO:0015562 efflux transmembrane transporter activity 2/993 16/18639 0.125 2.34629909365559 0.208528391093924 0.508111034407593 GO:0022841 potassium ion leak channel activity 2/993 16/18639 0.125 2.34629909365559 0.208528391093924 0.508111034407593 GO:0070411 I-SMAD binding 2/993 16/18639 0.125 2.34629909365559 0.208528391093924 0.508111034407593 GO:0031210 phosphatidylcholine binding 3/993 30/18639 0.1 1.87703927492447 0.213135602174273 0.516997845814622 GO:0098918 structural constituent of synapse 3/993 30/18639 0.1 1.87703927492447 0.213135602174273 0.516997845814622 GO:0017022 myosin binding 6/993 76/18639 0.0789473684210526 1.48187311178248 0.218018513814732 0.527653796356104 GO:0043178 alcohol binding 7/993 92/18639 0.0760869565217391 1.42818205700775 0.218722660263582 0.528171087676856 GO:0004842 ubiquitin-protein transferase activity 28/993 449/18639 0.0623608017817372 1.17053674160101 0.219352708468994 0.528507532485696 GO:0005452 solute:inorganic anion antiporter activity 3/993 31/18639 0.0967741935483871 1.81648962089465 0.227344200828492 0.544120614920745 GO:0008429 phosphatidylethanolamine binding 2/993 17/18639 0.117647058823529 2.20828149991114 0.228512074804291 0.544120614920745 GO:0031489 myosin V binding 2/993 17/18639 0.117647058823529 2.20828149991114 0.228512074804291 0.544120614920745 GO:0032977 membrane insertase activity 2/993 17/18639 0.117647058823529 2.20828149991114 0.228512074804291 0.544120614920745 GO:0046965 nuclear retinoid X receptor binding 2/993 17/18639 0.117647058823529 2.20828149991114 0.228512074804291 0.544120614920745 GO:0001217 DNA-binding transcription repressor activity 18/993 278/18639 0.0647482014388489 1.21534917081441 0.228864102654687 0.544120614920745 GO:0140359 ABC-type transporter activity 4/993 47/18639 0.0851063829787234 1.59748023397827 0.240107771253654 0.568422328925618 GO:0015106 bicarbonate transmembrane transporter activity 3/993 32/18639 0.09375 1.75972432024169 0.241724630128071 0.568422328925618 GO:0022884 macromolecule transmembrane transporter activity 3/993 32/18639 0.09375 1.75972432024169 0.241724630128071 0.568422328925618 GO:0031369 translation initiation factor binding 3/993 32/18639 0.09375 1.75972432024169 0.241724630128071 0.568422328925618 GO:0043425 bHLH transcription factor binding 3/993 32/18639 0.09375 1.75972432024169 0.241724630128071 0.568422328925618 GO:0008276 protein methyltransferase activity 7/993 95/18639 0.0736842105263158 1.38308157099698 0.242538404020789 0.56909337936904 GO:0008308 voltage-gated monoatomic anion channel activity 2/993 18/18639 0.111111111111111 2.08559919436052 0.248614808021242 0.572132795382217 GO:0008409 5'-3' exonuclease activity 2/993 18/18639 0.111111111111111 2.08559919436052 0.248614808021242 0.572132795382217 GO:0015172 acidic amino acid transmembrane transporter activity 2/993 18/18639 0.111111111111111 2.08559919436052 0.248614808021242 0.572132795382217 GO:0015373 monoatomic anion:sodium symporter activity 2/993 18/18639 0.111111111111111 2.08559919436052 0.248614808021242 0.572132795382217 GO:0016854 racemase and epimerase activity 2/993 18/18639 0.111111111111111 2.08559919436052 0.248614808021242 0.572132795382217 GO:0017128 phospholipid scramblase activity 2/993 18/18639 0.111111111111111 2.08559919436052 0.248614808021242 0.572132795382217 GO:0035615 clathrin adaptor activity 2/993 18/18639 0.111111111111111 2.08559919436052 0.248614808021242 0.572132795382217 GO:1901611 phosphatidylglycerol binding 2/993 18/18639 0.111111111111111 2.08559919436052 0.248614808021242 0.572132795382217 GO:1990381 ubiquitin-specific protease binding 2/993 18/18639 0.111111111111111 2.08559919436052 0.248614808021242 0.572132795382217 GO:0004896 cytokine receptor activity 7/993 96/18639 0.0729166666666667 1.36867447129909 0.250654609911464 0.575597046641038 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 4/993 48/18639 0.0833333333333333 1.56419939577039 0.251863270857374 0.577142005773174 GO:0019956 chemokine binding 3/993 33/18639 0.0909090909090909 1.70639934084043 0.256247624583674 0.584700617958935 GO:0140311 protein sequestering activity 3/993 33/18639 0.0909090909090909 1.70639934084043 0.256247624583674 0.584700617958935 GO:0061659 ubiquitin-like protein ligase activity 23/993 372/18639 0.0618279569892473 1.16053503557158 0.259239217696214 0.590276189130703 GO:0005543 phospholipid binding 30/993 497/18639 0.0603621730382294 1.13302169512544 0.26445231181419 0.600875822413254 GO:0004725 protein tyrosine phosphatase activity 7/993 98/18639 0.0714285714285714 1.34074233923177 0.267124335303557 0.601792816060091 GO:0008170 N-methyltransferase activity 7/993 98/18639 0.0714285714285714 1.34074233923177 0.267124335303557 0.601792816060091 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/993 19/18639 0.105263157894737 1.97583081570997 0.268767265111331 0.601792816060091 GO:0008381 mechanosensitive monoatomic ion channel activity 2/993 19/18639 0.105263157894737 1.97583081570997 0.268767265111331 0.601792816060091 GO:0022840 leak channel activity 2/993 19/18639 0.105263157894737 1.97583081570997 0.268767265111331 0.601792816060091 GO:0022842 narrow pore channel activity 2/993 19/18639 0.105263157894737 1.97583081570997 0.268767265111331 0.601792816060091 GO:0050145 nucleoside monophosphate kinase activity 2/993 19/18639 0.105263157894737 1.97583081570997 0.268767265111331 0.601792816060091 GO:0015399 primary active transmembrane transporter activity 11/993 166/18639 0.0662650602409639 1.24382120627525 0.271243562920395 0.606077421712169 GO:0051087 protein-folding chaperone binding 9/993 134/18639 0.0671641791044776 1.26069802047166 0.285533647426389 0.634230023103441 GO:0005154 epidermal growth factor receptor binding 3/993 35/18639 0.0857142857142857 1.60889080707812 0.285609620431912 0.634230023103441 GO:0010485 histone H4 acetyltransferase activity 3/993 35/18639 0.0857142857142857 1.60889080707812 0.285609620431912 0.634230023103441 GO:0005048 signal sequence binding 4/993 51/18639 0.0784313725490196 1.47218766660743 0.28776921534605 0.635006135608502 GO:0030544 Hsp70 protein binding 4/993 51/18639 0.0784313725490196 1.47218766660743 0.28776921534605 0.635006135608502 GO:0016791 phosphatase activity 17/993 273/18639 0.0622710622710623 1.16885229574051 0.288057407479643 0.635006135608502 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/993 20/18639 0.1 1.87703927492447 0.288907155476477 0.635006135608502 GO:0030742 GTP-dependent protein binding 2/993 20/18639 0.1 1.87703927492447 0.288907155476477 0.635006135608502 GO:0004860 protein kinase inhibitor activity 6/993 84/18639 0.0714285714285714 1.34074233923177 0.290071536368067 0.636266893418346 GO:0022853 active monoatomic ion transmembrane transporter activity 8/993 118/18639 0.0677966101694915 1.27256899994879 0.293081796816203 0.641563201567175 GO:0030145 manganese ion binding 5/993 68/18639 0.0735294117647059 1.38017593744446 0.295698181494979 0.645977568904854 GO:0042578 phosphoric ester hydrolase activity 22/993 363/18639 0.0606060606060606 1.13759956056029 0.296354780636686 0.646101414465002 GO:0030159 signaling receptor complex adaptor activity 4/993 52/18639 0.0769230769230769 1.44387636532652 0.299901381097751 0.652512701903592 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 6/993 86/18639 0.0697674418604651 1.30956228483103 0.308843763567656 0.666560432094531 GO:0005123 death receptor binding 2/993 21/18639 0.0952380952380952 1.78765645230902 0.308978671972462 0.666560432094531 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/993 21/18639 0.0952380952380952 1.78765645230902 0.308978671972462 0.666560432094531 GO:0072542 protein phosphatase activator activity 2/993 21/18639 0.0952380952380952 1.78765645230902 0.308978671972462 0.666560432094531 GO:0005253 monoatomic anion channel activity 7/993 103/18639 0.0679611650485437 1.27565775965741 0.30945238258799 0.666560432094531 GO:0008146 sulfotransferase activity 4/993 53/18639 0.0754716981132075 1.41663341503734 0.312091266227821 0.669566322166063 GO:0016860 intramolecular oxidoreductase activity 4/993 53/18639 0.0754716981132075 1.41663341503734 0.312091266227821 0.669566322166063 GO:0015631 tubulin binding 23/993 385/18639 0.0597402597402597 1.12134813826657 0.314948019711925 0.670946477930909 GO:0030551 cyclic nucleotide binding 3/993 37/18639 0.0810810810810811 1.52192373642525 0.315218206881554 0.670946477930909 GO:0008028 monocarboxylic acid transmembrane transporter activity 5/993 70/18639 0.0714285714285714 1.34074233923177 0.316812549626173 0.670946477930909 GO:0140030 modification-dependent protein binding 11/993 173/18639 0.0635838150289017 1.19349318058781 0.316837879226317 0.670946477930909 GO:0070851 growth factor receptor binding 9/993 139/18639 0.0647482014388489 1.21534917081441 0.322441836596117 0.670946477930909 GO:0003925 G protein activity 4/993 54/18639 0.0740740740740741 1.39039946290702 0.324324976178961 0.670946477930909 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 4/993 54/18639 0.0740740740740741 1.39039946290702 0.324324976178961 0.670946477930909 GO:0005243 gap junction channel activity 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0031683 G-protein beta/gamma-subunit complex binding 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0032931 histone H3K56 acetyltransferase activity 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0043992 histone H3K9 acetyltransferase activity 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0043993 histone H3K18 acetyltransferase activity 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0043994 histone H3K23 acetyltransferase activity 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0043999 histone H2AK5 acetyltransferase activity 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0044012 histone H2AK9 acetyltransferase activity 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0044014 histone H2BK5 acetyltransferase activity 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0044015 histone H2BK12 acetyltransferase activity 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0044016 histone H3K4 acetyltransferase activity 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0044017 histone H3K27 acetyltransferase activity 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0044018 histone H3K36 acetyltransferase activity 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0046972 histone H4K16 acetyltransferase activity 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0061133 endopeptidase activator activity 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0070034 telomerase RNA binding 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0140517 protein-RNA adaptor activity 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0140908 histone H3K122 acetyltransferase activity 2/993 22/18639 0.0909090909090909 1.70639934084043 0.328931978038551 0.670946477930909 GO:0043531 ADP binding 3/993 38/18639 0.0789473684210526 1.48187311178248 0.330053872266537 0.670972322428711 GO:0004721 phosphoprotein phosphatase activity 11/993 175/18639 0.0628571428571429 1.17985325852395 0.33019065077736 0.670972322428711 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 6/993 89/18639 0.0674157303370786 1.26541973590414 0.337356337433481 0.682956344766652 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 6/993 89/18639 0.0674157303370786 1.26541973590414 0.337356337433481 0.682956344766652 GO:0016776 phosphotransferase activity, phosphate group as acceptor 3/993 39/18639 0.0769230769230769 1.44387636532652 0.344880276936549 0.696549762142607 GO:0035091 phosphatidylinositol binding 17/993 284/18639 0.0598591549295775 1.12357984766606 0.345364506020569 0.696549762142607 GO:0019210 kinase inhibitor activity 6/993 90/18639 0.0666666666666667 1.25135951661631 0.346929149798896 0.69679848102287 GO:0140793 histone H2AXY142 phosphatase activity 6/993 90/18639 0.0666666666666667 1.25135951661631 0.346929149798896 0.69679848102287 GO:0004602 glutathione peroxidase activity 2/993 23/18639 0.0869565217391304 1.63220806515171 0.348722730985448 0.69679848102287 GO:0044013 histone H2B acetyltransferase activity 2/993 23/18639 0.0869565217391304 1.63220806515171 0.348722730985448 0.69679848102287 GO:0099186 structural constituent of postsynapse 2/993 23/18639 0.0869565217391304 1.63220806515171 0.348722730985448 0.69679848102287 GO:0015036 disulfide oxidoreductase activity 3/993 40/18639 0.075 1.40777945619335 0.359676304927419 0.712079743394908 GO:0050997 quaternary ammonium group binding 3/993 40/18639 0.075 1.40777945619335 0.359676304927419 0.712079743394908 GO:0061791 GTPase motor activity 3/993 40/18639 0.075 1.40777945619335 0.359676304927419 0.712079743394908 GO:0140662 ATP-dependent protein folding chaperone 3/993 40/18639 0.075 1.40777945619335 0.359676304927419 0.712079743394908 GO:1990606 membrane scission GTPase motor activity 3/993 40/18639 0.075 1.40777945619335 0.359676304927419 0.712079743394908 GO:0004601 peroxidase activity 4/993 57/18639 0.0701754385964912 1.31722054380665 0.361156056033879 0.71369738045594 GO:0016853 isomerase activity 11/993 180/18639 0.0611111111111111 1.14707955689829 0.364025266748867 0.718049839356282 GO:0043998 histone H2A acetyltransferase activity 2/993 24/18639 0.0833333333333333 1.56419939577039 0.368311639050474 0.72517666409024 GO:0001727 lipid kinase activity 3/993 41/18639 0.0731707317073171 1.37344337189595 0.374422047165471 0.734521939521333 GO:0140828 metal cation:monoatomic cation antiporter activity 3/993 41/18639 0.0731707317073171 1.37344337189595 0.374422047165471 0.734521939521333 GO:1902936 phosphatidylinositol bisphosphate binding 7/993 111/18639 0.0630630630630631 1.18371846166408 0.379322095711527 0.742781631056936 GO:0015459 potassium channel regulator activity 4/993 59/18639 0.0677966101694915 1.27256899994879 0.385692853778481 0.751002502577602 GO:0004709 MAP kinase kinase kinase activity 2/993 25/18639 0.08 1.50163141993958 0.38766404998068 0.751002502577602 GO:0019211 phosphatase activator activity 2/993 25/18639 0.08 1.50163141993958 0.38766404998068 0.751002502577602 GO:0042974 nuclear retinoic acid receptor binding 2/993 25/18639 0.08 1.50163141993958 0.38766404998068 0.751002502577602 GO:0005200 structural constituent of cytoskeleton 7/993 112/18639 0.0625 1.17314954682779 0.388140084125596 0.751002502577602 GO:0004402 histone acetyltransferase activity 3/993 42/18639 0.0714285714285714 1.34074233923177 0.389098789636306 0.751002502577602 GO:0016859 cis-trans isomerase activity 3/993 42/18639 0.0714285714285714 1.34074233923177 0.389098789636306 0.751002502577602 GO:0051879 Hsp90 protein binding 3/993 42/18639 0.0714285714285714 1.34074233923177 0.389098789636306 0.751002502577602 GO:0005262 calcium channel activity 8/993 131/18639 0.0610687022900763 1.14628352667143 0.398003926388178 0.756893059917768 GO:0031072 heat shock protein binding 8/993 131/18639 0.0610687022900763 1.14628352667143 0.398003926388178 0.756893059917768 GO:0016407 acetyltransferase activity 6/993 96/18639 0.0625 1.17314954682779 0.404652558520808 0.756893059917768 GO:0008143 poly(A) binding 2/993 26/18639 0.0769230769230769 1.44387636532652 0.406749569046919 0.756893059917768 GO:0030507 spectrin binding 2/993 26/18639 0.0769230769230769 1.44387636532652 0.406749569046919 0.756893059917768 GO:0034237 protein kinase A regulatory subunit binding 2/993 26/18639 0.0769230769230769 1.44387636532652 0.406749569046919 0.756893059917768 GO:0050681 nuclear androgen receptor binding 2/993 26/18639 0.0769230769230769 1.44387636532652 0.406749569046919 0.756893059917768 GO:0070412 R-SMAD binding 2/993 26/18639 0.0769230769230769 1.44387636532652 0.406749569046919 0.756893059917768 GO:0046982 protein heterodimerization activity 21/993 369/18639 0.0569105691056911 1.06823373369685 0.40938526368544 0.756893059917768 GO:0016836 hydro-lyase activity 4/993 61/18639 0.0655737704918033 1.23084542617998 0.410107073510878 0.756893059917768 GO:0001223 transcription coactivator binding 3/993 44/18639 0.0681818181818182 1.27979950563032 0.418176288094461 0.756893059917768 GO:0019205 nucleobase-containing compound kinase activity 3/993 44/18639 0.0681818181818182 1.27979950563032 0.418176288094461 0.756893059917768 GO:0061630 ubiquitin protein ligase activity 20/993 353/18639 0.056657223796034 1.06347834273341 0.421002873253643 0.756893059917768 GO:0001094 TFIID-class transcription factor complex binding 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0003796 lysozyme activity 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0004382 GDP phosphatase activity 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0004935 adrenergic receptor activity 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0005131 growth hormone receptor binding 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0005522 profilin binding 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0015203 polyamine transmembrane transporter activity 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0016427 tRNA (cytidine) methyltransferase activity 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0019531 oxalate transmembrane transporter activity 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0035256 G protein-coupled glutamate receptor binding 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0043121 neurotrophin binding 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0043208 glycosphingolipid binding 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0043295 glutathione binding 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0050815 phosphoserine residue binding 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0051378 serotonin binding 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0051880 G-quadruplex DNA binding 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0070513 death domain binding 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0140135 mechanosensitive monoatomic cation channel activity 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/993 10/18639 0.1 1.87703927492447 0.421667442851124 0.756893059917768 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/993 27/18639 0.0740740740740741 1.39039946290702 0.4255417045256 0.760047124003434 GO:0008266 poly(U) RNA binding 2/993 27/18639 0.0740740740740741 1.39039946290702 0.4255417045256 0.760047124003434 GO:0008320 protein transmembrane transporter activity 2/993 27/18639 0.0740740740740741 1.39039946290702 0.4255417045256 0.760047124003434 GO:0004715 non-membrane spanning protein tyrosine kinase activity 3/993 45/18639 0.0666666666666667 1.25135951661631 0.432545416896944 0.771102816660041 GO:0019789 SUMO transferase activity 2/993 28/18639 0.0714285714285714 1.34074233923177 0.444017538810109 0.771102816660041 GO:0036408 histone H3K14 acetyltransferase activity 2/993 28/18639 0.0714285714285714 1.34074233923177 0.444017538810109 0.771102816660041 GO:0051393 alpha-actinin binding 2/993 28/18639 0.0714285714285714 1.34074233923177 0.444017538810109 0.771102816660041 GO:0051959 dynein light intermediate chain binding 2/993 28/18639 0.0714285714285714 1.34074233923177 0.444017538810109 0.771102816660041 GO:0141052 histone H3 demethylase activity 2/993 28/18639 0.0714285714285714 1.34074233923177 0.444017538810109 0.771102816660041 GO:0004386 helicase activity 9/993 155/18639 0.0580645161290323 1.08989377253679 0.444455018459675 0.771102816660041 GO:0030291 protein serine/threonine kinase inhibitor activity 3/993 46/18639 0.0652173913043478 1.22415604886379 0.446782238045491 0.771102816660041 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0005225 volume-sensitive anion channel activity 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0005536 D-glucose binding 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0008503 benzodiazepine receptor activity 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0015173 aromatic amino acid transmembrane transporter activity 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0016594 glycine binding 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0034511 U3 snoRNA binding 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0050786 RAGE receptor binding 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0070990 snRNP binding 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0180030 inositol phosphate kinase activity 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:1900750 oligopeptide binding 1/993 11/18639 0.0909090909090909 1.70639934084043 0.452494874771723 0.771102816660041 GO:0005085 guanyl-nucleotide exchange factor activity 13/993 230/18639 0.0565217391304348 1.06093524234861 0.453901886662433 0.772278565458831 GO:0005254 chloride channel activity 5/993 83/18639 0.0602409638554217 1.13074655115932 0.455359489812101 0.773536546573553 GO:0120013 lipid transfer activity 4/993 65/18639 0.0615384615384615 1.15510109226121 0.458236164310971 0.77660188356732 GO:0061733 protein-lysine-acetyltransferase activity 3/993 47/18639 0.0638297872340425 1.19811017548371 0.460873678963116 0.77660188356732 GO:0004181 metallocarboxypeptidase activity 2/993 29/18639 0.0689655172413793 1.2945098447755 0.46215742343152 0.77660188356732 GO:0004629 phospholipase C activity 2/993 29/18639 0.0689655172413793 1.2945098447755 0.46215742343152 0.77660188356732 GO:0010484 histone H3 acetyltransferase activity 2/993 29/18639 0.0689655172413793 1.2945098447755 0.46215742343152 0.77660188356732 GO:0099604 ligand-gated calcium channel activity 2/993 29/18639 0.0689655172413793 1.2945098447755 0.46215742343152 0.77660188356732 GO:0016887 ATP hydrolysis activity 23/993 417/18639 0.0551558752997602 1.03529744180486 0.462550674518561 0.77660188356732 GO:0051082 unfolded protein binding 7/993 121/18639 0.0578512396694215 1.08589048962573 0.46713431732986 0.77660188356732 GO:0001965 G-protein alpha-subunit binding 2/993 30/18639 0.0666666666666667 1.25135951661631 0.479944696378466 0.77660188356732 GO:0008187 poly-pyrimidine tract binding 2/993 30/18639 0.0666666666666667 1.25135951661631 0.479944696378466 0.77660188356732 GO:0015215 nucleotide transmembrane transporter activity 2/993 30/18639 0.0666666666666667 1.25135951661631 0.479944696378466 0.77660188356732 GO:0032452 histone demethylase activity 2/993 30/18639 0.0666666666666667 1.25135951661631 0.479944696378466 0.77660188356732 GO:0043995 histone H4K5 acetyltransferase activity 2/993 30/18639 0.0666666666666667 1.25135951661631 0.479944696378466 0.77660188356732 GO:0043996 histone H4K8 acetyltransferase activity 2/993 30/18639 0.0666666666666667 1.25135951661631 0.479944696378466 0.77660188356732 GO:0043997 histone H4K12 acetyltransferase activity 2/993 30/18639 0.0666666666666667 1.25135951661631 0.479944696378466 0.77660188356732 GO:0051721 protein phosphatase 2A binding 2/993 30/18639 0.0666666666666667 1.25135951661631 0.479944696378466 0.77660188356732 GO:0000340 RNA 7-methylguanosine cap binding 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0005049 nuclear export signal receptor activity 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0005165 neurotrophin receptor binding 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0005436 sodium:phosphate symporter activity 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0015132 prostaglandin transmembrane transporter activity 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0015166 polyol transmembrane transporter activity 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0016208 AMP binding 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0034452 dynactin binding 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0035197 siRNA binding 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0035259 nuclear glucocorticoid receptor binding 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0042301 phosphate ion binding 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0070008 serine-type exopeptidase activity 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0140900 chloride:bicarbonate antiporter activity 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/993 12/18639 0.0833333333333333 1.56419939577039 0.481680648303593 0.77660188356732 GO:0015079 potassium ion transmembrane transporter activity 9/993 160/18639 0.05625 1.05583459214502 0.482451198336769 0.776681525573543 GO:0008081 phosphoric diester hydrolase activity 5/993 87/18639 0.0574712643678161 1.07875820397958 0.496810905204736 0.794944582381151 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/993 31/18639 0.0645161290322581 1.21099308059643 0.497365420209499 0.794944582381151 GO:0016411 acylglycerol O-acyltransferase activity 2/993 31/18639 0.0645161290322581 1.21099308059643 0.497365420209499 0.794944582381151 GO:0140457 protein demethylase activity 2/993 31/18639 0.0645161290322581 1.21099308059643 0.497365420209499 0.794944582381151 GO:0008083 growth factor activity 9/993 162/18639 0.0555555555555556 1.04279959718026 0.497486210329522 0.794944582381151 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 10/993 181/18639 0.0552486187845304 1.03703827343893 0.499317239259212 0.79496976157439 GO:0000149 SNARE binding 6/993 106/18639 0.0566037735849057 1.062475061278 0.499411725696294 0.79496976157439 GO:0015605 organophosphate ester transmembrane transporter activity 3/993 50/18639 0.06 1.12622356495468 0.502160371132256 0.79496976157439 GO:0032813 tumor necrosis factor receptor superfamily binding 3/993 50/18639 0.06 1.12622356495468 0.502160371132256 0.79496976157439 GO:0008080 N-acetyltransferase activity 4/993 69/18639 0.0579710144927536 1.08813871010114 0.504956407900706 0.79496976157439 GO:0002161 aminoacyl-tRNA editing activity 1/993 13/18639 0.0769230769230769 1.44387636532652 0.509312103515626 0.79496976157439 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/993 13/18639 0.0769230769230769 1.44387636532652 0.509312103515626 0.79496976157439 GO:0008035 high-density lipoprotein particle binding 1/993 13/18639 0.0769230769230769 1.44387636532652 0.509312103515626 0.79496976157439 GO:0008417 fucosyltransferase activity 1/993 13/18639 0.0769230769230769 1.44387636532652 0.509312103515626 0.79496976157439 GO:0009982 pseudouridine synthase activity 1/993 13/18639 0.0769230769230769 1.44387636532652 0.509312103515626 0.79496976157439 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/993 13/18639 0.0769230769230769 1.44387636532652 0.509312103515626 0.79496976157439 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/993 13/18639 0.0769230769230769 1.44387636532652 0.509312103515626 0.79496976157439 GO:0070700 BMP receptor binding 1/993 13/18639 0.0769230769230769 1.44387636532652 0.509312103515626 0.79496976157439 GO:0071714 icosanoid transmembrane transporter activity 1/993 13/18639 0.0769230769230769 1.44387636532652 0.509312103515626 0.79496976157439 GO:0071837 HMG box domain binding 1/993 13/18639 0.0769230769230769 1.44387636532652 0.509312103515626 0.79496976157439 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/993 13/18639 0.0769230769230769 1.44387636532652 0.509312103515626 0.79496976157439 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 26/993 484/18639 0.0537190082644628 1.00832688322389 0.511746267368576 0.797613212671427 GO:0070717 poly-purine tract binding 2/993 32/18639 0.0625 1.17314954682779 0.514408139548261 0.800603419499245 GO:0016782 transferase activity, transferring sulphur-containing groups 4/993 70/18639 0.0571428571428571 1.07259387138541 0.516359065977951 0.802480106866166 GO:0004843 cysteine-type deubiquitinase activity 6/993 108/18639 0.0555555555555556 1.04279959718026 0.517792592780988 0.80354844729845 GO:0071889 14-3-3 protein binding 2/993 33/18639 0.0606060606060606 1.13759956056029 0.53106365664275 0.815704777175739 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 9/993 167/18639 0.0538922155688623 1.01157805235451 0.534500155218327 0.815704777175739 GO:0005313 L-glutamate transmembrane transporter activity 1/993 14/18639 0.0714285714285714 1.34074233923177 0.535471938220285 0.815704777175739 GO:0008174 mRNA methyltransferase activity 1/993 14/18639 0.0714285714285714 1.34074233923177 0.535471938220285 0.815704777175739 GO:0008191 metalloendopeptidase inhibitor activity 1/993 14/18639 0.0714285714285714 1.34074233923177 0.535471938220285 0.815704777175739 GO:0008559 ABC-type xenobiotic transporter activity 1/993 14/18639 0.0714285714285714 1.34074233923177 0.535471938220285 0.815704777175739 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/993 14/18639 0.0714285714285714 1.34074233923177 0.535471938220285 0.815704777175739 GO:0019992 diacylglycerol binding 1/993 14/18639 0.0714285714285714 1.34074233923177 0.535471938220285 0.815704777175739 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/993 14/18639 0.0714285714285714 1.34074233923177 0.535471938220285 0.815704777175739 GO:0043176 amine binding 1/993 14/18639 0.0714285714285714 1.34074233923177 0.535471938220285 0.815704777175739 GO:0046030 inositol trisphosphate phosphatase activity 1/993 14/18639 0.0714285714285714 1.34074233923177 0.535471938220285 0.815704777175739 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/993 14/18639 0.0714285714285714 1.34074233923177 0.535471938220285 0.815704777175739 GO:0061783 peptidoglycan muralytic activity 1/993 14/18639 0.0714285714285714 1.34074233923177 0.535471938220285 0.815704777175739 GO:0072341 modified amino acid binding 5/993 91/18639 0.0549450549450549 1.03134026094751 0.537015190486692 0.81690022620645 GO:0004864 protein phosphatase inhibitor activity 3/993 53/18639 0.0566037735849057 1.062475061278 0.541763723956995 0.818749063991016 GO:0005544 calcium-dependent phospholipid binding 3/993 53/18639 0.0566037735849057 1.062475061278 0.541763723956995 0.818749063991016 GO:0034212 protein N-acetyltransferase activity 3/993 53/18639 0.0566037735849057 1.062475061278 0.541763723956995 0.818749063991016 GO:0140296 general transcription initiation factor binding 3/993 53/18639 0.0566037735849057 1.062475061278 0.541763723956995 0.818749063991016 GO:0001216 DNA-binding transcription activator activity 26/993 491/18639 0.0529531568228106 0.993951550876502 0.542031645891917 0.818749063991016 GO:0052689 carboxylic ester hydrolase activity 5/993 92/18639 0.0543478260869565 1.02013004071982 0.546835609472727 0.820987235632864 GO:0015035 protein-disulfide reductase activity 2/993 34/18639 0.0588235294117647 1.10414074995557 0.547324823755243 0.820987235632864 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/993 34/18639 0.0588235294117647 1.10414074995557 0.547324823755243 0.820987235632864 GO:0030332 cyclin binding 2/993 34/18639 0.0588235294117647 1.10414074995557 0.547324823755243 0.820987235632864 GO:0052866 phosphatidylinositol phosphate phosphatase activity 2/993 34/18639 0.0588235294117647 1.10414074995557 0.547324823755243 0.820987235632864 GO:0000774 adenyl-nucleotide exchange factor activity 1/993 15/18639 0.0666666666666667 1.25135951661631 0.560238454480541 0.824285267043091 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/993 15/18639 0.0666666666666667 1.25135951661631 0.560238454480541 0.824285267043091 GO:0005523 tropomyosin binding 1/993 15/18639 0.0666666666666667 1.25135951661631 0.560238454480541 0.824285267043091 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/993 15/18639 0.0666666666666667 1.25135951661631 0.560238454480541 0.824285267043091 GO:0017081 chloride channel regulator activity 1/993 15/18639 0.0666666666666667 1.25135951661631 0.560238454480541 0.824285267043091 GO:0033130 acetylcholine receptor binding 1/993 15/18639 0.0666666666666667 1.25135951661631 0.560238454480541 0.824285267043091 GO:0034483 heparan sulfate sulfotransferase activity 1/993 15/18639 0.0666666666666667 1.25135951661631 0.560238454480541 0.824285267043091 GO:0050700 CARD domain binding 1/993 15/18639 0.0666666666666667 1.25135951661631 0.560238454480541 0.824285267043091 GO:0050780 dopamine receptor binding 1/993 15/18639 0.0666666666666667 1.25135951661631 0.560238454480541 0.824285267043091 GO:0051371 muscle alpha-actinin binding 1/993 15/18639 0.0666666666666667 1.25135951661631 0.560238454480541 0.824285267043091 GO:0140161 monocarboxylate:sodium symporter activity 1/993 15/18639 0.0666666666666667 1.25135951661631 0.560238454480541 0.824285267043091 GO:0140776 protein-containing complex destabilizing activity 1/993 15/18639 0.0666666666666667 1.25135951661631 0.560238454480541 0.824285267043091 GO:0141050 histone H3K deacetylase activity 1/993 15/18639 0.0666666666666667 1.25135951661631 0.560238454480541 0.824285267043091 GO:0141051 histone H4K deacetylase activity 1/993 15/18639 0.0666666666666667 1.25135951661631 0.560238454480541 0.824285267043091 GO:0043015 gamma-tubulin binding 2/993 35/18639 0.0571428571428571 1.07259387138541 0.563186351229384 0.827492087686285 GO:0008374 O-acyltransferase activity 3/993 55/18639 0.0545454545454545 1.02383960450426 0.567129155869681 0.832150001187529 GO:0044183 protein folding chaperone 4/993 75/18639 0.0533333333333333 1.00108761329305 0.57140520986749 0.837056721739949 GO:0000993 RNA polymerase II complex binding 2/993 36/18639 0.0555555555555556 1.04279959718026 0.578644630155915 0.837056721739949 GO:0045505 dynein intermediate chain binding 2/993 36/18639 0.0555555555555556 1.04279959718026 0.578644630155915 0.837056721739949 GO:0055106 ubiquitin-protein transferase regulator activity 2/993 36/18639 0.0555555555555556 1.04279959718026 0.578644630155915 0.837056721739949 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 2/993 36/18639 0.0555555555555556 1.04279959718026 0.578644630155915 0.837056721739949 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 2/993 36/18639 0.0555555555555556 1.04279959718026 0.578644630155915 0.837056721739949 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 2/993 36/18639 0.0555555555555556 1.04279959718026 0.578644630155915 0.837056721739949 GO:0019212 phosphatase inhibitor activity 3/993 56/18639 0.0535714285714286 1.00555675442382 0.579483433296384 0.837056721739949 GO:0101005 deubiquitinase activity 6/993 115/18639 0.0521739130434783 0.979324839091029 0.579843746517599 0.837056721739949 GO:0000062 fatty-acyl-CoA binding 1/993 16/18639 0.0625 1.17314954682779 0.583685792039649 0.837056721739949 GO:0005149 interleukin-1 receptor binding 1/993 16/18639 0.0625 1.17314954682779 0.583685792039649 0.837056721739949 GO:0005521 lamin binding 1/993 16/18639 0.0625 1.17314954682779 0.583685792039649 0.837056721739949 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/993 16/18639 0.0625 1.17314954682779 0.583685792039649 0.837056721739949 GO:0030275 LRR domain binding 1/993 16/18639 0.0625 1.17314954682779 0.583685792039649 0.837056721739949 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/993 16/18639 0.0625 1.17314954682779 0.583685792039649 0.837056721739949 GO:0043023 ribosomal large subunit binding 1/993 16/18639 0.0625 1.17314954682779 0.583685792039649 0.837056721739949 GO:0055102 lipase inhibitor activity 1/993 16/18639 0.0625 1.17314954682779 0.583685792039649 0.837056721739949 GO:0140789 histone phosphatase activity 7/993 136/18639 0.0514705882352941 0.966123156211125 0.591734618992155 0.843071355126753 GO:0022829 wide pore channel activity 2/993 37/18639 0.0540540540540541 1.0146158242835 0.593697568628735 0.843071355126753 GO:0042805 actinin binding 2/993 37/18639 0.0540540540540541 1.0146158242835 0.593697568628735 0.843071355126753 GO:0043021 ribonucleoprotein complex binding 9/993 177/18639 0.0508474576271186 0.954426749961596 0.605211285712647 0.843071355126753 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0005092 GDP-dissociation inhibitor activity 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0008569 minus-end-directed microtubule motor activity 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0015278 intracellularly gated calcium channel activity 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0016018 cyclosporin A binding 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0016805 dipeptidase activity 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0017110 nucleoside diphosphate phosphatase activity 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0030169 low-density lipoprotein particle binding 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0030548 acetylcholine receptor regulator activity 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0032183 SUMO binding 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0036041 long-chain fatty acid binding 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0048038 quinone binding 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0051787 misfolded protein binding 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0070402 NADPH binding 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0070403 NAD+ binding 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:1901567 fatty acid derivative binding 1/993 17/18639 0.0588235294117647 1.10414074995557 0.605884149366858 0.843071355126753 GO:0000146 microfilament motor activity 2/993 38/18639 0.0526315789473684 0.987915407854985 0.608344440648857 0.845402532359766 GO:0016835 carbon-oxygen lyase activity 4/993 79/18639 0.0506329113924051 0.95039963287315 0.612806217741926 0.849410935016801 GO:0033293 monocarboxylic acid binding 4/993 79/18639 0.0506329113924051 0.95039963287315 0.612806217741926 0.849410935016801 GO:0045309 protein phosphorylated amino acid binding 3/993 59/18639 0.0508474576271186 0.954426749961596 0.615182337075235 0.849424842346189 GO:0070063 RNA polymerase binding 3/993 59/18639 0.0508474576271186 0.954426749961596 0.615182337075235 0.849424842346189 GO:0070888 E-box binding 3/993 59/18639 0.0508474576271186 0.954426749961596 0.615182337075235 0.849424842346189 GO:0043130 ubiquitin binding 5/993 100/18639 0.05 0.938519637462236 0.621499084627323 0.850341678129133 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 2/993 39/18639 0.0512820512820513 0.962584243551011 0.622585746795469 0.850341678129133 GO:0048306 calcium-dependent protein binding 4/993 80/18639 0.05 0.938519637462236 0.622760960235766 0.850341678129133 GO:0001098 basal transcription machinery binding 3/993 60/18639 0.05 0.938519637462236 0.626617156663898 0.850341678129133 GO:0001099 basal RNA polymerase II transcription machinery binding 3/993 60/18639 0.05 0.938519637462236 0.626617156663898 0.850341678129133 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/993 18/18639 0.0555555555555556 1.04279959718026 0.626899992975424 0.850341678129133 GO:0004706 JUN kinase kinase kinase activity 1/993 18/18639 0.0555555555555556 1.04279959718026 0.626899992975424 0.850341678129133 GO:0015280 ligand-gated sodium channel activity 1/993 18/18639 0.0555555555555556 1.04279959718026 0.626899992975424 0.850341678129133 GO:0017075 syntaxin-1 binding 1/993 18/18639 0.0555555555555556 1.04279959718026 0.626899992975424 0.850341678129133 GO:0022851 GABA-gated chloride ion channel activity 1/993 18/18639 0.0555555555555556 1.04279959718026 0.626899992975424 0.850341678129133 GO:0031690 adrenergic receptor binding 1/993 18/18639 0.0555555555555556 1.04279959718026 0.626899992975424 0.850341678129133 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/993 18/18639 0.0555555555555556 1.04279959718026 0.626899992975424 0.850341678129133 GO:0070628 proteasome binding 1/993 18/18639 0.0555555555555556 1.04279959718026 0.626899992975424 0.850341678129133 GO:0099602 neurotransmitter receptor regulator activity 1/993 18/18639 0.0555555555555556 1.04279959718026 0.626899992975424 0.850341678129133 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/993 40/18639 0.05 0.938519637462236 0.636423085841155 0.858931909086371 GO:0032451 demethylase activity 2/993 40/18639 0.05 0.938519637462236 0.636423085841155 0.858931909086371 GO:0071855 neuropeptide receptor binding 2/993 40/18639 0.05 0.938519637462236 0.636423085841155 0.858931909086371 GO:0071949 FAD binding 2/993 40/18639 0.05 0.938519637462236 0.636423085841155 0.858931909086371 GO:0004890 GABA-A receptor activity 1/993 19/18639 0.0526315789473684 0.987915407854985 0.64679625563454 0.86319648986171 GO:0005229 intracellularly calcium-gated chloride channel activity 1/993 19/18639 0.0526315789473684 0.987915407854985 0.64679625563454 0.86319648986171 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/993 19/18639 0.0526315789473684 0.987915407854985 0.64679625563454 0.86319648986171 GO:0008301 DNA binding, bending 1/993 19/18639 0.0526315789473684 0.987915407854985 0.64679625563454 0.86319648986171 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/993 19/18639 0.0526315789473684 0.987915407854985 0.64679625563454 0.86319648986171 GO:0031420 alkali metal ion binding 1/993 19/18639 0.0526315789473684 0.987915407854985 0.64679625563454 0.86319648986171 GO:0097001 ceramide binding 1/993 19/18639 0.0526315789473684 0.987915407854985 0.64679625563454 0.86319648986171 GO:0120227 acyl-CoA binding 1/993 19/18639 0.0526315789473684 0.987915407854985 0.64679625563454 0.86319648986171 GO:0141147 intracellularly calcium-gated channel activity 1/993 19/18639 0.0526315789473684 0.987915407854985 0.64679625563454 0.86319648986171 GO:0017080 sodium channel regulator activity 2/993 41/18639 0.0487804878048781 0.915628914597303 0.649859036542473 0.866210621728024 GO:0008135 translation factor activity, RNA binding 4/993 83/18639 0.0481927710843374 0.904597240927456 0.651637744545016 0.866727614321347 GO:0008168 methyltransferase activity 10/993 204/18639 0.0490196078431373 0.920117291629643 0.651856423027197 0.866727614321347 GO:0180051 translation factor activity 4/993 84/18639 0.0476190476190476 0.89382822615451 0.660928594137852 0.873186636317702 GO:0004520 DNA endonuclease activity 2/993 42/18639 0.0476190476190476 0.89382822615451 0.662897048887781 0.873186636317702 GO:0043175 RNA polymerase core enzyme binding 2/993 42/18639 0.0476190476190476 0.89382822615451 0.662897048887781 0.873186636317702 GO:0000339 RNA cap binding 1/993 20/18639 0.05 0.938519637462236 0.665632524063912 0.873186636317702 GO:0001972 retinoic acid binding 1/993 20/18639 0.05 0.938519637462236 0.665632524063912 0.873186636317702 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/993 20/18639 0.05 0.938519637462236 0.665632524063912 0.873186636317702 GO:0016408 C-acyltransferase activity 1/993 20/18639 0.05 0.938519637462236 0.665632524063912 0.873186636317702 GO:0016505 peptidase activator activity involved in apoptotic process 1/993 20/18639 0.05 0.938519637462236 0.665632524063912 0.873186636317702 GO:0043024 ribosomal small subunit binding 1/993 20/18639 0.05 0.938519637462236 0.665632524063912 0.873186636317702 GO:0052745 inositol phosphate phosphatase activity 1/993 20/18639 0.05 0.938519637462236 0.665632524063912 0.873186636317702 GO:0140939 histone H4 methyltransferase activity 1/993 20/18639 0.05 0.938519637462236 0.665632524063912 0.873186636317702 GO:0004536 DNA nuclease activity 3/993 64/18639 0.046875 0.879862160120846 0.669985073467685 0.877827158302551 GO:0008200 ion channel inhibitor activity 2/993 43/18639 0.0465116279069767 0.873041523220684 0.675541344131785 0.882256220422392 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/993 43/18639 0.0465116279069767 0.873041523220684 0.675541344131785 0.882256220422392 GO:0019783 ubiquitin-like protein peptidase activity 6/993 127/18639 0.047244094488189 0.886790208625734 0.675823010072863 0.882256220422392 GO:0001846 opsonin binding 1/993 21/18639 0.0476190476190476 0.89382822615451 0.683465216668484 0.886857877532479 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/993 21/18639 0.0476190476190476 0.89382822615451 0.683465216668484 0.886857877532479 GO:0010314 phosphatidylinositol-5-phosphate binding 1/993 21/18639 0.0476190476190476 0.89382822615451 0.683465216668484 0.886857877532479 GO:0035613 RNA stem-loop binding 1/993 21/18639 0.0476190476190476 0.89382822615451 0.683465216668484 0.886857877532479 GO:0061891 calcium ion sensor activity 1/993 21/18639 0.0476190476190476 0.89382822615451 0.683465216668484 0.886857877532479 GO:0008094 ATP-dependent activity, acting on DNA 10/993 210/18639 0.0476190476190476 0.89382822615451 0.687110877011319 0.890333147068497 GO:0016248 channel inhibitor activity 2/993 44/18639 0.0454545454545455 0.853199670420214 0.687796822990706 0.890333147068497 GO:0042605 peptide antigen binding 2/993 45/18639 0.0444444444444444 0.834239677744209 0.699668981413672 0.900088936435706 GO:0141110 transporter inhibitor activity 2/993 45/18639 0.0444444444444444 0.834239677744209 0.699668981413672 0.900088936435706 GO:0004407 histone deacetylase activity 1/993 22/18639 0.0454545454545455 0.853199670420214 0.700347751841338 0.900088936435706 GO:0008970 phospholipase A1 activity 1/993 22/18639 0.0454545454545455 0.853199670420214 0.700347751841338 0.900088936435706 GO:0033558 protein lysine deacetylase activity 1/993 22/18639 0.0454545454545455 0.853199670420214 0.700347751841338 0.900088936435706 GO:0140784 metal ion sensor activity 1/993 22/18639 0.0454545454545455 0.853199670420214 0.700347751841338 0.900088936435706 GO:0003727 single-stranded RNA binding 4/993 89/18639 0.0449438202247191 0.843613157269425 0.70482813153176 0.902140172555653 GO:1990841 promoter-specific chromatin binding 3/993 68/18639 0.0441176470588235 0.828105562466679 0.709543229634453 0.902140172555653 GO:0005126 cytokine receptor binding 13/993 275/18639 0.0472727272727273 0.887327657237023 0.710639629487178 0.902140172555653 GO:0004180 carboxypeptidase activity 2/993 46/18639 0.0434782608695652 0.816104032575857 0.711163833384953 0.902140172555653 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/993 46/18639 0.0434782608695652 0.816104032575857 0.711163833384953 0.902140172555653 GO:0008236 serine-type peptidase activity 9/993 194/18639 0.0463917525773196 0.870791416202074 0.71165046375489 0.902140172555653 GO:0016741 transferase activity, transferring one-carbon groups 10/993 215/18639 0.0465116279069767 0.873041523220684 0.714774099977349 0.902140172555653 GO:0008017 microtubule binding 13/993 276/18639 0.0471014492753623 0.884112701957179 0.715423873065469 0.902140172555653 GO:0000295 adenine nucleotide transmembrane transporter activity 1/993 23/18639 0.0434782608695652 0.816104032575857 0.716330707334788 0.902140172555653 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/993 23/18639 0.0434782608695652 0.816104032575857 0.716330707334788 0.902140172555653 GO:0005212 structural constituent of eye lens 1/993 23/18639 0.0434782608695652 0.816104032575857 0.716330707334788 0.902140172555653 GO:0016493 C-C chemokine receptor activity 1/993 23/18639 0.0434782608695652 0.816104032575857 0.716330707334788 0.902140172555653 GO:0016917 GABA receptor activity 1/993 23/18639 0.0434782608695652 0.816104032575857 0.716330707334788 0.902140172555653 GO:0031681 G-protein beta-subunit binding 1/993 23/18639 0.0434782608695652 0.816104032575857 0.716330707334788 0.902140172555653 GO:0042171 lysophosphatidic acid acyltransferase activity 1/993 23/18639 0.0434782608695652 0.816104032575857 0.716330707334788 0.902140172555653 GO:0071617 lysophospholipid acyltransferase activity 1/993 23/18639 0.0434782608695652 0.816104032575857 0.716330707334788 0.902140172555653 GO:0043022 ribosome binding 5/993 112/18639 0.0446428571428571 0.837963962019853 0.718562906858687 0.902140172555653 GO:0001784 phosphotyrosine residue binding 2/993 47/18639 0.0425531914893617 0.798740116989137 0.722287840248145 0.902140172555653 GO:0061749 forked DNA-dependent helicase activity 2/993 47/18639 0.0425531914893617 0.798740116989137 0.722287840248145 0.902140172555653 GO:0099095 ligand-gated monoatomic anion channel activity 2/993 47/18639 0.0425531914893617 0.798740116989137 0.722287840248145 0.902140172555653 GO:1990518 single-stranded 3'-5' DNA helicase activity 2/993 47/18639 0.0425531914893617 0.798740116989137 0.722287840248145 0.902140172555653 GO:0004252 serine-type endopeptidase activity 8/993 176/18639 0.0454545454545455 0.853199670420214 0.726493186279629 0.902140172555653 GO:0140375 immune receptor activity 7/993 156/18639 0.0448717948717949 0.842261213107135 0.731321913518265 0.902140172555653 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/993 24/18639 0.0416666666666667 0.782099697885196 0.731461971173236 0.902140172555653 GO:0004622 lysophospholipase activity 1/993 24/18639 0.0416666666666667 0.782099697885196 0.731461971173236 0.902140172555653 GO:0005315 phosphate transmembrane transporter activity 1/993 24/18639 0.0416666666666667 0.782099697885196 0.731461971173236 0.902140172555653 GO:0019957 C-C chemokine binding 1/993 24/18639 0.0416666666666667 0.782099697885196 0.731461971173236 0.902140172555653 GO:0030552 cAMP binding 1/993 24/18639 0.0416666666666667 0.782099697885196 0.731461971173236 0.902140172555653 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/993 24/18639 0.0416666666666667 0.782099697885196 0.731461971173236 0.902140172555653 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/993 24/18639 0.0416666666666667 0.782099697885196 0.731461971173236 0.902140172555653 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/993 24/18639 0.0416666666666667 0.782099697885196 0.731461971173236 0.902140172555653 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/993 24/18639 0.0416666666666667 0.782099697885196 0.731461971173236 0.902140172555653 GO:0009378 four-way junction helicase activity 2/993 48/18639 0.0416666666666667 0.782099697885196 0.733047846077623 0.902140172555653 GO:0032266 phosphatidylinositol-3-phosphate binding 2/993 48/18639 0.0416666666666667 0.782099697885196 0.733047846077623 0.902140172555653 GO:0036121 double-stranded DNA helicase activity 2/993 48/18639 0.0416666666666667 0.782099697885196 0.733047846077623 0.902140172555653 GO:0038187 pattern recognition receptor activity 2/993 48/18639 0.0416666666666667 0.782099697885196 0.733047846077623 0.902140172555653 GO:0043138 3'-5' DNA helicase activity 2/993 48/18639 0.0416666666666667 0.782099697885196 0.733047846077623 0.902140172555653 GO:0017171 serine hydrolase activity 9/993 198/18639 0.0454545454545455 0.853199670420214 0.733774179348887 0.902140172555653 GO:0051219 phosphoprotein binding 4/993 93/18639 0.043010752688172 0.807328720397622 0.736870962122302 0.904518552553031 GO:0140658 ATP-dependent chromatin remodeler activity 7/993 158/18639 0.0443037974683544 0.831599678764006 0.743264883411765 0.904518552553031 GO:0016763 pentosyltransferase activity 2/993 49/18639 0.0408163265306122 0.766138479561009 0.743451018654541 0.904518552553031 GO:0035254 glutamate receptor binding 2/993 49/18639 0.0408163265306122 0.766138479561009 0.743451018654541 0.904518552553031 GO:0060590 ATPase regulator activity 2/993 49/18639 0.0408163265306122 0.766138479561009 0.743451018654541 0.904518552553031 GO:0016410 N-acyltransferase activity 4/993 94/18639 0.0425531914893617 0.798740116989137 0.744457620175016 0.904518552553031 GO:0015271 outward rectifier potassium channel activity 1/993 25/18639 0.04 0.750815709969789 0.745786884556259 0.904518552553031 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/993 25/18639 0.04 0.750815709969789 0.745786884556259 0.904518552553031 GO:0017056 structural constituent of nuclear pore 1/993 25/18639 0.04 0.750815709969789 0.745786884556259 0.904518552553031 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/993 25/18639 0.04 0.750815709969789 0.745786884556259 0.904518552553031 GO:0019707 protein-cysteine S-acyltransferase activity 1/993 25/18639 0.04 0.750815709969789 0.745786884556259 0.904518552553031 GO:0047617 fatty acyl-CoA hydrolase activity 1/993 25/18639 0.04 0.750815709969789 0.745786884556259 0.904518552553031 GO:0099106 ion channel regulator activity 7/993 160/18639 0.04375 0.821204682779456 0.754829144283049 0.908686891354704 GO:0001637 G protein-coupled chemoattractant receptor activity 1/993 26/18639 0.0384615384615385 0.721938182663258 0.759348377176633 0.908686891354704 GO:0004529 DNA exonuclease activity 1/993 26/18639 0.0384615384615385 0.721938182663258 0.759348377176633 0.908686891354704 GO:0004950 chemokine receptor activity 1/993 26/18639 0.0384615384615385 0.721938182663258 0.759348377176633 0.908686891354704 GO:0005227 calcium-activated cation channel activity 1/993 26/18639 0.0384615384615385 0.721938182663258 0.759348377176633 0.908686891354704 GO:0008198 ferrous iron binding 1/993 26/18639 0.0384615384615385 0.721938182663258 0.759348377176633 0.908686891354704 GO:0015216 purine nucleotide transmembrane transporter activity 1/993 26/18639 0.0384615384615385 0.721938182663258 0.759348377176633 0.908686891354704 GO:0016289 acyl-CoA hydrolase activity 1/993 26/18639 0.0384615384615385 0.721938182663258 0.759348377176633 0.908686891354704 GO:0030247 polysaccharide binding 1/993 26/18639 0.0384615384615385 0.721938182663258 0.759348377176633 0.908686891354704 GO:0043548 phosphatidylinositol 3-kinase binding 1/993 26/18639 0.0384615384615385 0.721938182663258 0.759348377176633 0.908686891354704 GO:0052742 phosphatidylinositol kinase activity 1/993 26/18639 0.0384615384615385 0.721938182663258 0.759348377176633 0.908686891354704 GO:0097602 cullin family protein binding 1/993 26/18639 0.0384615384615385 0.721938182663258 0.759348377176633 0.908686891354704 GO:0003678 DNA helicase activity 3/993 74/18639 0.0405405405405405 0.760961868212624 0.761889482453401 0.91028187359724 GO:0003743 translation initiation factor activity 2/993 51/18639 0.0392156862745098 0.736093833303714 0.763216835523034 0.91028187359724 GO:0005272 sodium channel activity 2/993 51/18639 0.0392156862745098 0.736093833303714 0.763216835523034 0.91028187359724 GO:0019003 GDP binding 3/993 75/18639 0.04 0.750815709969789 0.769826327144481 0.914407746155613 GO:0001671 ATPase activator activity 1/993 27/18639 0.037037037037037 0.695199731453508 0.772187095355519 0.914407746155613 GO:0004364 glutathione transferase activity 1/993 27/18639 0.037037037037037 0.695199731453508 0.772187095355519 0.914407746155613 GO:0015252 proton channel activity 1/993 27/18639 0.037037037037037 0.695199731453508 0.772187095355519 0.914407746155613 GO:0023026 MHC class II protein complex binding 1/993 27/18639 0.037037037037037 0.695199731453508 0.772187095355519 0.914407746155613 GO:0035255 ionotropic glutamate receptor binding 1/993 27/18639 0.037037037037037 0.695199731453508 0.772187095355519 0.914407746155613 GO:0032182 ubiquitin-like protein binding 5/993 120/18639 0.0416666666666667 0.782099697885196 0.772619358404464 0.914407746155613 GO:0015078 proton transmembrane transporter activity 8/993 185/18639 0.0432432432432432 0.811692659426798 0.775189429170024 0.916442387723509 GO:0140104 molecular carrier activity 11/993 249/18639 0.0441767068273092 0.829214137516835 0.779384117265815 0.920391112165881 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 10/993 229/18639 0.0436681222707424 0.819667805643874 0.78354300258444 0.92102389235967 GO:0016866 intramolecular transferase activity 1/993 28/18639 0.0357142857142857 0.670371169615883 0.78434152337572 0.92102389235967 GO:0046625 sphingolipid binding 1/993 28/18639 0.0357142857142857 0.670371169615883 0.78434152337572 0.92102389235967 GO:0051019 mitogen-activated protein kinase binding 1/993 28/18639 0.0357142857142857 0.670371169615883 0.78434152337572 0.92102389235967 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/993 28/18639 0.0357142857142857 0.670371169615883 0.78434152337572 0.92102389235967 GO:0003724 RNA helicase activity 3/993 77/18639 0.038961038961039 0.731314003217327 0.785051005743897 0.92102389235967 GO:0000287 magnesium ion binding 10/993 230/18639 0.0434782608695652 0.816104032575857 0.787960072056393 0.923430900549222 GO:0016874 ligase activity 7/993 167/18639 0.0419161676646707 0.78678292960906 0.792342373854805 0.927557322436549 GO:0140097 catalytic activity, acting on DNA 15/993 336/18639 0.0446428571428571 0.837963962019853 0.794840792201976 0.927628140636909 GO:0016417 S-acyltransferase activity 1/993 29/18639 0.0344827586206897 0.647254922387749 0.795848098373727 0.927628140636909 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/993 29/18639 0.0344827586206897 0.647254922387749 0.795848098373727 0.927628140636909 GO:0051861 glycolipid binding 1/993 29/18639 0.0344827586206897 0.647254922387749 0.795848098373727 0.927628140636909 GO:0016247 channel regulator activity 7/993 168/18639 0.0416666666666667 0.782099697885196 0.797329994378429 0.928350706968181 GO:0008186 ATP-dependent activity, acting on RNA 3/993 79/18639 0.0379746835443038 0.712799724654863 0.799432501262812 0.929793524686878 GO:0001664 G protein-coupled receptor binding 13/993 297/18639 0.0437710437710438 0.821599682626873 0.804219811769124 0.930592236007154 GO:0000049 tRNA binding 3/993 80/18639 0.0375 0.703889728096677 0.806315808056074 0.930592236007154 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/993 30/18639 0.0333333333333333 0.625679758308157 0.806741319132184 0.930592236007154 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/993 30/18639 0.0333333333333333 0.625679758308157 0.806741319132184 0.930592236007154 GO:0022839 monoatomic ion-gated channel activity 1/993 30/18639 0.0333333333333333 0.625679758308157 0.806741319132184 0.930592236007154 GO:0033612 receptor serine/threonine kinase binding 1/993 30/18639 0.0333333333333333 0.625679758308157 0.806741319132184 0.930592236007154 GO:0048019 receptor antagonist activity 1/993 30/18639 0.0333333333333333 0.625679758308157 0.806741319132184 0.930592236007154 GO:0141108 transporter regulator activity 7/993 170/18639 0.0411764705882353 0.7728985249689 0.807031706992276 0.930592236007154 GO:0005164 tumor necrosis factor receptor binding 1/993 31/18639 0.032258064516129 0.605496540298217 0.817053849096273 0.93813112524167 GO:0008327 methyl-CpG binding 1/993 31/18639 0.032258064516129 0.605496540298217 0.817053849096273 0.93813112524167 GO:0047499 calcium-independent phospholipase A2 activity 1/993 31/18639 0.032258064516129 0.605496540298217 0.817053849096273 0.93813112524167 GO:0070273 phosphatidylinositol-4-phosphate binding 1/993 31/18639 0.032258064516129 0.605496540298217 0.817053849096273 0.93813112524167 GO:0017116 single-stranded DNA helicase activity 2/993 58/18639 0.0344827586206897 0.647254922387749 0.822303376148413 0.942937649848353 GO:0005216 monoatomic ion channel activity 20/993 448/18639 0.0446428571428571 0.837963962019853 0.822991077862073 0.942937649848353 GO:0030515 snoRNA binding 1/993 32/18639 0.03125 0.586574773413897 0.826816613920403 0.945309440756129 GO:0047498 calcium-dependent phospholipase A2 activity 1/993 32/18639 0.03125 0.586574773413897 0.826816613920403 0.945309440756129 GO:0001786 phosphatidylserine binding 2/993 59/18639 0.0338983050847458 0.636284499974397 0.829570781028174 0.945775099546972 GO:0036002 pre-mRNA binding 2/993 59/18639 0.0338983050847458 0.636284499974397 0.829570781028174 0.945775099546972 GO:0003774 cytoskeletal motor activity 6/993 153/18639 0.0392156862745098 0.736093833303714 0.8307365312641 0.945775099546972 GO:0061775 cohesin loader activity 6/993 153/18639 0.0392156862745098 0.736093833303714 0.8307365312641 0.945775099546972 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/993 33/18639 0.0303030303030303 0.568799780280143 0.83605889383533 0.947408000917121 GO:0019239 deaminase activity 1/993 33/18639 0.0303030303030303 0.568799780280143 0.83605889383533 0.947408000917121 GO:0042923 neuropeptide binding 1/993 33/18639 0.0303030303030303 0.568799780280143 0.83605889383533 0.947408000917121 GO:0140416 transcription regulator inhibitor activity 1/993 33/18639 0.0303030303030303 0.568799780280143 0.83605889383533 0.947408000917121 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/993 60/18639 0.0333333333333333 0.625679758308157 0.836569181868321 0.947408000917121 GO:0004620 phospholipase activity 4/993 109/18639 0.036697247706422 0.688821752265861 0.838992650708778 0.949154500854364 GO:0008175 tRNA methyltransferase activity 1/993 34/18639 0.0294117647058824 0.552070374977786 0.844808411110484 0.952731579859676 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/993 34/18639 0.0294117647058824 0.552070374977786 0.844808411110484 0.952731579859676 GO:0051427 hormone receptor binding 1/993 34/18639 0.0294117647058824 0.552070374977786 0.844808411110484 0.952731579859676 GO:0003924 GTPase activity 14/993 331/18639 0.0422960725075529 0.793913892717299 0.847203319787529 0.954433028672771 GO:0004623 phospholipase A2 activity 1/993 35/18639 0.0285714285714286 0.536296935692706 0.853091412871692 0.958059907886145 GO:0061631 ubiquitin conjugating enzyme activity 1/993 35/18639 0.0285714285714286 0.536296935692706 0.853091412871692 0.958059907886145 GO:0140566 histone reader activity 1/993 35/18639 0.0285714285714286 0.536296935692706 0.853091412871692 0.958059907886145 GO:0004033 aldo-keto reductase (NADPH) activity 1/993 36/18639 0.0277777777777778 0.521399798590131 0.860932749520715 0.961851214972832 GO:0004869 cysteine-type endopeptidase inhibitor activity 1/993 36/18639 0.0277777777777778 0.521399798590131 0.860932749520715 0.961851214972832 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/993 36/18639 0.0277777777777778 0.521399798590131 0.860932749520715 0.961851214972832 GO:0005484 SNAP receptor activity 1/993 36/18639 0.0277777777777778 0.521399798590131 0.860932749520715 0.961851214972832 GO:0016409 palmitoyltransferase activity 1/993 36/18639 0.0277777777777778 0.521399798590131 0.860932749520715 0.961851214972832 GO:0019843 rRNA binding 2/993 65/18639 0.0307692307692308 0.577550546130607 0.867802800797942 0.964690554600962 GO:0160215 deacylase activity 2/993 65/18639 0.0307692307692308 0.577550546130607 0.867802800797942 0.964690554600962 GO:0019213 deacetylase activity 1/993 37/18639 0.027027027027027 0.507307912141749 0.868355948989936 0.964690554600962 GO:0023023 MHC protein complex binding 1/993 37/18639 0.027027027027027 0.507307912141749 0.868355948989936 0.964690554600962 GO:0030280 structural constituent of skin epidermis 1/993 37/18639 0.027027027027027 0.507307912141749 0.868355948989936 0.964690554600962 GO:0140767 enzyme-substrate adaptor activity 5/993 139/18639 0.0359712230215827 0.675193983785781 0.868848503215351 0.964690554600962 GO:0009055 electron transfer activity 4/993 116/18639 0.0344827586206897 0.647254922387749 0.871936793527038 0.96696184631416 GO:0005261 monoatomic cation channel activity 14/993 341/18639 0.0410557184750733 0.770631960379548 0.874790091537921 0.96696184631416 GO:0005501 retinoid binding 1/993 38/18639 0.0263157894736842 0.493957703927492 0.875383287053209 0.96696184631416 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/993 38/18639 0.0263157894736842 0.493957703927492 0.875383287053209 0.96696184631416 GO:0019840 isoprenoid binding 1/993 38/18639 0.0263157894736842 0.493957703927492 0.875383287053209 0.96696184631416 GO:0008173 RNA methyltransferase activity 2/993 67/18639 0.0298507462686567 0.560310231320738 0.878685296460183 0.968864108935797 GO:0140597 protein carrier chaperone 7/993 188/18639 0.0372340425531915 0.698897602365495 0.878904581643708 0.968864108935797 GO:0000217 DNA secondary structure binding 1/993 39/18639 0.0256410256410256 0.481292121775505 0.882035853902096 0.970329534885146 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/993 39/18639 0.0256410256410256 0.481292121775505 0.882035853902096 0.970329534885146 GO:0004532 RNA exonuclease activity 1/993 40/18639 0.025 0.469259818731118 0.88833361718571 0.976260516029602 GO:0004812 aminoacyl-tRNA ligase activity 1/993 41/18639 0.024390243902439 0.457814457298652 0.894295481701791 0.978817310765071 GO:0008227 G protein-coupled amine receptor activity 1/993 41/18639 0.024390243902439 0.457814457298652 0.894295481701791 0.978817310765071 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/993 41/18639 0.024390243902439 0.457814457298652 0.894295481701791 0.978817310765071 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/993 41/18639 0.024390243902439 0.457814457298652 0.894295481701791 0.978817310765071 GO:0003730 mRNA 3'-UTR binding 10/993 262/18639 0.0381679389312977 0.716427204169646 0.896681576028678 0.980432545566382 GO:0140299 molecular sensor activity 2/993 71/18639 0.028169014084507 0.528743457725203 0.898008052411178 0.980887091731074 GO:0042056 chemoattractant activity 1/993 42/18639 0.0238095238095238 0.446914113077255 0.899939345916767 0.982000684450211 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/993 43/18639 0.0232558139534884 0.436520761610342 0.905282155483076 0.98264484667401 GO:0005245 voltage-gated calcium channel activity 1/993 43/18639 0.0232558139534884 0.436520761610342 0.905282155483076 0.98264484667401 GO:0004521 RNA endonuclease activity 2/993 73/18639 0.0273972602739726 0.514257335595745 0.906556643138381 0.98264484667401 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 2/993 73/18639 0.0273972602739726 0.514257335595745 0.906556643138381 0.98264484667401 GO:0000510 H3-H4 histone complex chaperone activity 5/993 151/18639 0.033112582781457 0.621536183749825 0.909873264992838 0.98264484667401 GO:0140584 chromatin extrusion motor activity 5/993 151/18639 0.033112582781457 0.621536183749825 0.909873264992838 0.98264484667401 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 5/993 151/18639 0.033112582781457 0.621536183749825 0.909873264992838 0.98264484667401 GO:0140849 ATP-dependent H2AZ histone chaperone activity 5/993 151/18639 0.033112582781457 0.621536183749825 0.909873264992838 0.98264484667401 GO:0016790 thiolester hydrolase activity 1/993 44/18639 0.0227272727272727 0.426599835210107 0.910339953913131 0.98264484667401 GO:0030547 signaling receptor inhibitor activity 1/993 44/18639 0.0227272727272727 0.426599835210107 0.910339953913131 0.98264484667401 GO:0031491 nucleosome binding 2/993 74/18639 0.027027027027027 0.507307912141749 0.91057517537963 0.98264484667401 GO:0015616 DNA translocase activity 5/993 152/18639 0.0328947368421053 0.617447129909366 0.912722438064025 0.98264484667401 GO:0140674 ATP-dependent histone chaperone activity 5/993 152/18639 0.0328947368421053 0.617447129909366 0.912722438064025 0.98264484667401 GO:0031490 chromatin DNA binding 4/993 128/18639 0.03125 0.586574773413897 0.91496720834473 0.98264484667401 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 4/993 128/18639 0.03125 0.586574773413897 0.91496720834473 0.98264484667401 GO:0051539 4 iron, 4 sulfur cluster binding 1/993 45/18639 0.0222222222222222 0.417119838872105 0.915127930560847 0.98264484667401 GO:0005506 iron ion binding 5/993 154/18639 0.0324675324675325 0.609428336014439 0.918184375178831 0.984944792896017 GO:0016298 lipase activity 4/993 130/18639 0.0307692307692308 0.577550546130607 0.920729053683596 0.985710925265639 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 4/993 130/18639 0.0307692307692308 0.577550546130607 0.920729053683596 0.985710925265639 GO:0005504 fatty acid binding 1/993 47/18639 0.0212765957446809 0.399370058494568 0.923951175310285 0.988178168628776 GO:0005179 hormone activity 4/993 132/18639 0.0303030303030303 0.568799780280143 0.926138403064231 0.989534781845413 GO:0008188 neuropeptide receptor activity 1/993 48/18639 0.0208333333333333 0.391049848942598 0.928012948272682 0.990554950733081 GO:0003689 DNA clamp loader activity 5/993 160/18639 0.03125 0.586574773413897 0.93280130624928 0.994680204782648 GO:0030971 receptor tyrosine kinase binding 2/993 81/18639 0.0246913580246914 0.463466487635672 0.934475322435071 0.995479646154868 GO:0099094 ligand-gated monoatomic cation channel activity 4/993 136/18639 0.0294117647058824 0.552070374977786 0.935970559601619 0.996087245742039 GO:0140713 histone chaperone activity 5/993 164/18639 0.0304878048780488 0.572268071623314 0.941203167276022 0.999555837439691 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/993 52/18639 0.0192307692307692 0.360969091331629 0.94220520506205 0.999555837439691 GO:0004527 exonuclease activity 2/993 84/18639 0.0238095238095238 0.446914113077255 0.942744360562312 0.999555837439691 GO:0050660 flavin adenine dinucleotide binding 2/993 86/18639 0.0232558139534884 0.436520761610342 0.947695038540175 0.999555837439691 GO:0050661 NADP binding 1/993 54/18639 0.0185185185185185 0.347599865726754 0.948215714818021 0.999555837439691 GO:0051287 NAD binding 1/993 54/18639 0.0185185185185185 0.347599865726754 0.948215714818021 0.999555837439691 GO:0030170 pyridoxal phosphate binding 1/993 56/18639 0.0178571428571429 0.335185584807941 0.953601710699696 0.999555837439691 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/993 56/18639 0.0178571428571429 0.335185584807941 0.953601710699696 0.999555837439691 GO:0022836 gated channel activity 11/993 318/18639 0.0345911949685535 0.649290315225446 0.955195558231607 0.999555837439691 GO:0070279 vitamin B6 binding 1/993 57/18639 0.0175438596491228 0.329305135951662 0.956081046720533 0.999555837439691 GO:0005244 voltage-gated monoatomic ion channel activity 5/993 173/18639 0.0289017341040462 0.542496900267188 0.95674668966139 0.999555837439691 GO:0016829 lyase activity 6/993 200/18639 0.03 0.563111782477341 0.958808797625827 0.999555837439691 GO:0004540 RNA nuclease activity 3/993 121/18639 0.0247933884297521 0.465381638411026 0.95956301656499 0.999555837439691 GO:0022832 voltage-gated channel activity 5/993 175/18639 0.0285714285714286 0.536296935692706 0.959646292940231 0.999555837439691 GO:0031593 polyubiquitin modification-dependent protein binding 1/993 59/18639 0.0169491525423729 0.318142249987199 0.960649699989807 0.999555837439691 GO:0008528 G protein-coupled peptide receptor activity 3/993 122/18639 0.0245901639344262 0.461567034817493 0.961181054739522 0.999555837439691 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/993 122/18639 0.0245901639344262 0.461567034817493 0.961181054739522 0.999555837439691 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 1/993 60/18639 0.0166666666666667 0.312839879154079 0.962752759618984 0.999555837439691 GO:0005267 potassium channel activity 3/993 124/18639 0.0241935483870968 0.454122405223662 0.964236276143164 0.999555837439691 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 1/993 61/18639 0.0163934426229508 0.307711356544995 0.964743529288953 0.999555837439691 GO:0019001 guanyl nucleotide binding 14/993 400/18639 0.035 0.656963746223565 0.967211659109877 0.999555837439691 GO:0032561 guanyl ribonucleotide binding 14/993 400/18639 0.035 0.656963746223565 0.967211659109877 0.999555837439691 GO:0004519 endonuclease activity 3/993 127/18639 0.0236220472440945 0.443395104312867 0.968397439941913 0.999555837439691 GO:0030594 neurotransmitter receptor activity 2/993 97/18639 0.0206185567010309 0.387018407200922 0.968398693974981 0.999555837439691 GO:0022824 transmitter-gated monoatomic ion channel activity 1/993 63/18639 0.0158730158730159 0.297942742051503 0.968411838924159 0.999555837439691 GO:0022835 transmitter-gated channel activity 1/993 63/18639 0.0158730158730159 0.297942742051503 0.968411838924159 0.999555837439691 GO:0005125 cytokine activity 7/993 234/18639 0.0299145299145299 0.561507475404756 0.968962504261657 0.999555837439691 GO:0001653 peptide receptor activity 3/993 128/18639 0.0234375 0.439931080060423 0.969679765500246 0.999555837439691 GO:0015276 ligand-gated monoatomic ion channel activity 5/993 186/18639 0.0268817204301075 0.504580450248514 0.972643689948605 0.999555837439691 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3/993 132/18639 0.0227272727272727 0.426599835210107 0.974333120351809 0.999555837439691 GO:0022834 ligand-gated channel activity 5/993 188/18639 0.0265957446808511 0.49921257311821 0.974541879854003 0.999555837439691 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/993 67/18639 0.0149253731343284 0.280155115660369 0.974644071664467 0.999555837439691 GO:0003777 microtubule motor activity 1/993 68/18639 0.0147058823529412 0.276035187488893 0.975999791933538 0.999555837439691 GO:0140223 general transcription initiation factor activity 1/993 68/18639 0.0147058823529412 0.276035187488893 0.975999791933538 0.999555837439691 GO:0004722 protein serine/threonine phosphatase activity 2/993 103/18639 0.0194174757281553 0.364473645616402 0.976092427177602 0.999555837439691 GO:0098960 postsynaptic neurotransmitter receptor activity 1/993 69/18639 0.0144927536231884 0.272034677525286 0.977283094211821 0.999555837439691 GO:0003684 damaged DNA binding 1/993 74/18639 0.0135135135135135 0.253653956070874 0.982741612837804 0.999555837439691 GO:0051536 iron-sulfur cluster binding 1/993 76/18639 0.0131578947368421 0.246978851963746 0.984538509161481 0.999555837439691 GO:0051540 metal cluster binding 1/993 77/18639 0.012987012987013 0.243771334405776 0.985365598554502 0.999555837439691 GO:0033192 calmodulin-dependent protein phosphatase activity 1/993 81/18639 0.0123456790123457 0.231733243817836 0.98825491600827 0.999555837439691 GO:0140791 histone H2AXS140 phosphatase activity 1/993 81/18639 0.0123456790123457 0.231733243817836 0.98825491600827 0.999555837439691 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 1/993 81/18639 0.0123456790123457 0.231733243817836 0.98825491600827 0.999555837439691 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 1/993 81/18639 0.0123456790123457 0.231733243817836 0.98825491600827 0.999555837439691 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 1/993 81/18639 0.0123456790123457 0.231733243817836 0.98825491600827 0.999555837439691 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 1/993 81/18639 0.0123456790123457 0.231733243817836 0.98825491600827 0.999555837439691 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 1/993 81/18639 0.0123456790123457 0.231733243817836 0.98825491600827 0.999555837439691 GO:1990439 MAP kinase serine/threonine phosphatase activity 1/993 81/18639 0.0123456790123457 0.231733243817836 0.98825491600827 0.999555837439691 GO:0004518 nuclease activity 5/993 209/18639 0.0239234449760766 0.449052458115902 0.988281873494272 0.999555837439691 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 1/993 82/18639 0.0121951219512195 0.228907228649326 0.988883371035955 0.999555837439691 GO:0033549 MAP kinase phosphatase activity 1/993 82/18639 0.0121951219512195 0.228907228649326 0.988883371035955 0.999555837439691 GO:0046906 tetrapyrrole binding 3/993 152/18639 0.0197368421052632 0.370468277945619 0.989063717615523 0.999555837439691 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 1/993 83/18639 0.0120481927710843 0.226149310231864 0.989478230795685 0.999555837439691 GO:0003697 single-stranded DNA binding 2/993 121/18639 0.0165289256198347 0.310254425607351 0.989797961989794 0.999555837439691 GO:0017018 myosin phosphatase activity 1/993 84/18639 0.0119047619047619 0.223457056538628 0.990041289473195 0.999555837439691 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 2/993 122/18639 0.0163934426229508 0.307711356544995 0.990274910443965 0.999555837439691 GO:0005525 GTP binding 11/993 378/18639 0.0291005291005291 0.546228360427756 0.991879063472771 0.999917669468613 GO:0005249 voltage-gated potassium channel activity 1/993 98/18639 0.0102040816326531 0.191534619890252 0.995390383292352 0.999917669468613 GO:0140101 catalytic activity, acting on a tRNA 2/993 139/18639 0.0143884892086331 0.270077593514312 0.9957239651839 0.999917669468613 GO:0022843 voltage-gated monoatomic cation channel activity 2/993 143/18639 0.013986013986014 0.262522975513912 0.99648250724632 0.999917669468613 GO:0140098 catalytic activity, acting on RNA 9/993 387/18639 0.0232558139534884 0.436520761610342 0.998966416251238 0.999917669468613 GO:0003823 antigen binding 2/993 174/18639 0.0114942528735632 0.215751640795916 0.999241378611455 0.999917669468613 GO:0016779 nucleotidyltransferase activity 1/993 136/18639 0.00735294117647059 0.138017593744446 0.999432034914847 0.999917669468613 GO:0020037 heme binding 1/993 142/18639 0.00704225352112676 0.132185864431301 0.999592088779115 0.999917669468613 GO:0045182 translation regulator activity 7/993 356/18639 0.0196629213483146 0.369080756305374 0.999623553143846 0.999917669468613 GO:0030371 translation repressor activity 5/993 329/18639 0.0151975683890578 0.28526432749612 0.999917669468613 0.999917669468613