category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	164/2885	250/9376	2.1319431542461	CTSC/PSAP/GAA/SLC38A9/CLTC/LGMN/HEXA/FUCA1/GNS/CTSD/ASAH1/HEXB/MANBA/CTSV/VPS13C/GLB1/GNPTAB/MCOLN3/CTSL/GUSB/VPS13A/HGSNAT/ATP6AP1/SCARB2/NAGLU/CTSA/SLC17A5/ATP6V1B1/AP2A2/LAMP2/CTSO/LAMP1/SLC29A3/CTSF/SUMF1/SLC11A2/GM2A/CLN5/LIPA/SMPD1/TLR3/TPP1/CTBS/NPC1/SPG11/SORT1/AP2A1/NEU1/ABCA5/SLC29A1/AP3D1/ATP6V0A1/ACP2/DMXL1/CTSB/FUCA2/CLN3/ENTPD4/AP2B1/ATP6V1H/IGF2R/PPT1/PLA2G15/AP1S3/BLOC1S6/VPS35/PIKFYVE/DNASE2/AP1B1/NAGA/ATP6V0B/CD164/AP3B1/AP4E1/SGSH/GGA1/MTOR/OSTM1/ATP6V1C2/AP3S2/OSBP/IDS/GLA/RRAGC/CLN8/OSBPL3/TPCN1/STX17/HYAL2/ATP6V1A/VPS39/ARSG/GNPTG/TMEM175/M6PR/AP1G1/CTSZ/DMXL2/MFSD8/AGA/GALC/LAPTM4A/PPT2/GGA3/CLCN7/AP5M1/TCIRG1/AP3M1/NCOA7/CLN6/AP3M2/SLC15A4/RRAGB/AP1M1/VPS41/OSBPL2/SLC29A2/TFEB/ATP6V1E2/SLC15A3/ARSA/TFE3/ATP6V0A2/NAGPA/ARL8A/PLEKHM1/FIG4/VPS11/WDR7/ACP5/OSBPL1A/RPTOR/ATP6V0A4/ATP6V1B2/AP1G2/ROGDI/AP5S1/BORCS6/MCOLN1/SLC36A4/TTI1/VAMP7/BLOC1S5/TELO2/ABCB9/VPS33A/BORCS5/ARSB/AP5B1/VPS26B/AP5Z1/GALNS/VPS18/GPR155/ZFYVE26/CTNS/HYAL4/AP4M1/SPAM1/MCOLN2/LAMP3/TPCN2/AP4B1/VPS16	12.093642653377
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	111/2885	174/9376	2.07322058208331	RRBP1/LMAN1/HSPA5/RPN2/GANAB/CANX/SEC62/TUSC3/PDIA4/SIL1/HSP90B1/PDIA3/CKAP4/P4HB/MAN1A2/UBXN4/STT3B/SEL1L/MBTPS1/EDEM3/CALR/ERP29/OS9/SEC31A/ATF6/ERLEC1/DDOST/SEC63/SEC61A1/MOGS/DNAJC3/RPN1/BCL2/UBE4B/PRKCSH/PPP1R15A/ERO1B/NFE2L2/STT3A/TRAM1/DNAJB1/PDIA6/UGGT2/UBE2G2/SEC24D/HSPA4L/AMFR/ATF6B/DNAJC10/XBP1/UGGT1/SSR1/LMAN2/MAGT1/MAN1B1/WFS1/DDIT3/UBXN2A/DNAJC1/HYOU1/EDEM2/MAN1A1/MAN1C1/HSPA1B/UBQLN1/NPLOC4/HSPA8/DNAJB11/SEC24A/HSPH1/CUL1/SEC24B/SVIP/HSPA1A/MAPK8/MBTPS2/BCAP29/SAR1B/BCAP31/CAPN1/SYVN1/SAR1A/SEC23A/VCP/DERL2/DERL1/STUB1/MAP2K7/DNAJB12/UBXN8/EIF2AK3/ERN1/SEC61A2/UBQLN2/DNAJC5/PLAA/ATXN3/PREB/SEC23B/YOD1/SEC31B/SEC24C/EDEM1/DNAJB2/UBXN6/TRAM1L1/CAPN2/TXNDC5/UBQLN4/RNF185/MAP3K5	9.52632173528438
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	99/2885	169/9376	1.90379539138371	IGF1R/CTSD/BIRC6/CTSL/RB1CC1/LAMP2/C9orf72/KRAS/LAMP1/UVRAG/BCL2/EIF2AK4/CFLAR/PIK3R1/WDFY3/ATG9A/VMP1/PDPK1/PIK3CA/NBR1/IRS2/CTSB/PIK3R3/PIK3CB/SUPT20H/MTMR3/AKT3/RPS6KB1/ATG14/MTOR/ULK2/OPTN/AKT2/PTEN/RRAGC/MAPK8/WIPI2/WDR45B/ATG12/MRAS/WIPI1/STX17/VPS39/ATG2B/ATG2A/STX7/MAP3K7/RAB7B/TSC2/PRKACB/TSC1/EPG5/GORASP2/MAPK1/PIK3C3/HRAS/ATG4D/DAPK1/GABARAPL1/BCL2L1/EIF2AK3/ATG10/ERN1/RRAGB/MTMR4/CAMKK2/NRBF2/PRKAA1/VPS41/ATG4B/RAF1/PIK3R4/ATG9B/PLEKHM1/BECN1/GORASP1/ULK1/VPS11/RPTOR/HIF1A/TBK1/SMCR8/ATG7/PRKACA/VPS33A/ATG13/ZFYVE1/STK11/PRKAA2/IRS1/RAB33B/VPS18/ITPR1/TRAF6/ATG16L2/AMBRA1/ATG4A/VPS16/TP53INP2	7.90418589298507
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	57/2885	83/9376	2.23186820070577	JARID2/EP300/MTF2/CBX4/SUZ12/KDM2A/DCAF7/AEBP2/PHC3/TEX10/MGA/CREBBP/YY1/OGT/YAF2/USP7/LCOR/SFMBT2/FOXK1/HCFC1/HDAC2/BMI1/ASXL2/ASXL1/RBBP4/USP16/PHC1/L3MBTL3/MBD6/SFMBT1/BAP1/FOXK2/EZH1/CBX6/BCORL1/PCGF3/AUTS2/EED/FBRS/EZH2/FBRSL1/MAX/L3MBTL2/BCOR/MBD5/L3MBTL1/E2F6/KDM2B/CBX7/SCML1/WDR5B/USP45/YY2/SCML2/SCMH1/CBX8/PHF1	7.51498407370518
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	68/2885	108/9376	2.04624173566981	TPR/PNN/TNPO1/RANBP2/UPF2/KPNB1/THOC2/RANBP17/IPO7/KPNA6/UPF3A/TMEM33/POM121/XPO1/AHCTF1/UPF1/POM121C/DDX39B/IPO9/IPO8/NUP210/NUP58/NUP153/NUP205/NUP98/CASC3/NUP155/NXF1/UPF3B/XPO6/NUP133/DDX19A/KPNA4/NUP160/SRRM1/NUP214/ACIN1/IPO5/PHAX/NUP107/NCBP1/XPO7/NDC1/XPOT/TNPO3/RNPS1/KPNA3/TNPO2/NUP50/XPO4/KPNA1/SUMO4/NUP88/THOC1/NUP188/SENP2/IPO13/AAAS/NUP62/KPNA5/IPO11/NMD3/NUP43/SEH1L/NUP85/XPO5/GLE1/IPO4	7.29043845513039
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	83/2885	142/9376	1.89959723680035	DDB1/BIRC6/HUWE1/UBR5/UBE2H/WWP1/HERC2/SIAH1/UBE4A/HERC4/UBE4B/TRIP12/RHOBTB1/MDM2/MAP3K1/CUL5/FBXW11/SKP2/UBE2G2/UBE3A/XIAP/NEDD4/KLHL9/PIAS1/BIRC2/UBA6/UBA1/HERC1/ANAPC5/CBL/SMURF2/UBE3C/SOCS1/PPIL2/ANAPC4/UBE2E2/CUL1/NEDD4L/ITCH/TRIM37/ANAPC1/UBE2Q1/FBXW7/MGRN1/SYVN1/UBE2R2/UBE2Z/UBA3/BRCA1/CDC23/VHL/UBE3B/CDC16/STUB1/CDC27/FBXW8/CUL3/CUL2/RHOBTB2/BTRC/FANCL/UBE2W/CUL7/CUL4B/HERC3/WWP2/CUL4A/UBOX5/UBE2O/SMURF1/FZR1/ANAPC7/KEAP1/FBXO4/PIAS4/UBA7/PIAS3/TRAF6/TRIM32/MID1/PML/PIAS2/ANAPC2	7.20112073215307
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	52/2885	78/9376	2.16660889659157	ISYNA1/SACM1L/PIK3C2A/SYNJ1/PIP5K1A/PIK3CA/INPPL1/PIK3CB/PIKFYVE/PI4KA/MTMR3/IP6K2/PLCG2/PPIP5K2/CDIPT/IP6K1/MINPP1/PIP5K1B/PTEN/INPP1/INPP4A/INPP5F/PIP4K2B/PI4KB/PIK3C3/PLCB1/PLCE1/MTMR6/MTMR4/INPP5A/PI4K2A/PI4K2B/PIP5K1C/FIG4/PIK3C2B/SYNJ2/MTMR1/IPMK/IMPA1/PPIP5K1/PIP4K2C/ALDH6A1/ITPKC/OCRL/INPP5B/MTM1/INPP5K/INPP5E/IPPK/MTMR2/ITPK1/PLCG1	6.89732288052953
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	91/2885	170/9376	1.73965949638087	EGFR/MET/CDK6/SMARCA2/IGF1R/LRP5/TCF7L2/GADD45B/GAB1/ARID1A/PBRM1/DVL3/KRAS/FZD5/TGFBR1/FZD6/NFE2L2/BRD7/PIK3R1/GSK3B/SMARCC1/TGFBR2/FZD3/PIK3CA/SMAD2/MGST3/ARID2/SMAD4/PIK3R3/PIK3CB/APC/SMARCA4/ARID1B/SOS1/SMARCD1/CSNK1A1/FZD10/AKT3/RPS6KB1/PLCG2/POLK/SHC1/MTOR/MGST2/CDKN1A/CCND1/AKT2/BRAF/PTEN/SMARCD2/SOS2/E2F3/CTNNB1/WNT4/TXNRD1/PHF10/SMARCE1/GADD45A/MAPK1/SMARCC2/GADD45G/LRP6/HRAS/TP53/BCL2L1/WNT5A/AXIN2/RAF1/RB1/TXNRD2/DVL1/GSTM3/WNT2B/MYC/ARAF/SMAD3/GSTM2/FZD1/WNT3/KEAP1/PRKCA/FZD8/TCF7/DVL2/TXNRD3/FRAT2/AXIN1/GSTO2/TCF7L1/WNT7A/PLCG1	6.48818994021572
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	122/2885	250/9376	1.58595771230503	EGFR/TFRC/CLTC/EEA1/IGF1R/KIF5B/ZFYVE16/AP2A2/WWP1/FOLR1/FGFR2/RAB11FIP1/ARFGEF1/PRKCI/TGFBR1/EPN2/CYTH3/PARD3/MDM2/USP8/VPS36/RABEP1/SH3KBP1/DAB2/WIPF2/NEDD4/RAB11FIP4/TGFBR2/LDLR/AP2A1/IST1/PIP5K1A/DNAJC6/PSD3/SMAD2/RAB5B/RAB31/RAB11FIP2/AP2B1/WASL/IGF2R/CBL/ACTR2/ARFGEF2/SMURF2/VPS35/ZFYVE9/GBF1/HSPA1B/MVB12B/HGS/EPN3/EPS15/PSD4/ASAP1/IQSEC1/HSPA8/PARD6B/GIT2/ACAP2/PIP5K1B/NEDD4L/ITCH/AGAP1/EHD1/HSPA1A/EHD3/SH3GLB2/LDLRAP1/PDCD6IP/CHMP4C/HLA-E/CHMP1B/ARFGAP2/RAB10/RUFY2/VPS4B/PRKCZ/SPG21/HRAS/VPS45/AGAP3/RBSN/VPS37C/PIP5K1C/ZFYVE27/PLD2/ACTR3C/EPN1/ARRB1/SNX12/ACAP3/GIT1/SMURF1/ARAP1/RAB22A/PLD1/SMAD3/AGAP9/EPS15L1/STAM2/DNM2/GRK5/CHMP1A/ARFGAP1/CYTH2/AGAP4/VPS26B/RNF41/CHMP7/RAB11FIP3/AGAP6/TRAF6/PARD6G/VPS37B/AGAP5/SRC/GRK4/PML/ACTR3B/IQSEC2/CXCR2	6.26035252391003
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	39/2885	56/9376	2.26333250804655	RPN2/GANAB/TUSC3/B4GALT1/MAN1A2/FUT8/STT3B/MAN2A1/DDOST/MOGS/RPN1/STT3A/MAGT1/MAN2A2/MAN1B1/ALG10B/ALG8/MAN1A1/MAN1C1/ALG2/DPM3/MGAT1/ALG5/MGAT3/ALG6/DPAGT1/DOLK/ALG11/MGAT2/ALG1/ALG14/ALG9/ALG12/DOLPP1/ALG10/MGAT4A/SRD5A3/MGAT5/B4GALT3	6.32130101050664
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	38/2885	54/9376	2.28697605751332	REV3L/REV1/BRCA2/HES1/ATR/POLK/FANCM/POLI/USP1/ERCC4/TOP3A/FAN1/BRCA1/RPA1/WDR48/FANCE/FANCA/FANCL/FANCB/TOP3B/FANCF/FANCD2/RPA4/MLH1/TELO2/POLH/FANCI/RMI1/MUS81/BLM/FANCC/PALB2/SLX4/FAAP100/EME2/PMS2/SLX1A/BRIP1	6.32288874920489
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	49/2885	77/9376	2.06812667401922	CDK6/GADD45B/KRAS/TGFBR1/MDM2/PIK3R1/TGFBR2/PIK3CA/SMAD4/PIK3R3/PIK3CB/CBL/NFKBIA/PTPN11/SOS1/AKT3/NFKB1/POLK/SHC1/HDAC2/CDKN1A/CCND1/AKT2/BRAF/CRK/SOS2/E2F3/IKBKB/BCR/CTBP1/CDKN1B/GADD45A/MAPK1/GADD45G/HRAS/TP53/BCL2L1/CTBP2/CRKL/RAF1/ABL1/RB1/STAT5B/CHUK/MYC/ARAF/SMAD3/IKBKG/GAB2	6.27411885847787
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	84/2885	158/9376	1.7278020314591	ATRX/PRKDC/CDK6/NIPBL/TFDP2/GADD45B/PDS5A/EP300/WAPL/STAG1/MDM2/SMC1A/ATM/SKP2/GSK3B/PDS5B/STAG2/MCM6/CREBBP/SMC3/ESCO1/SMAD2/RAD21/MCM2/SMAD4/ANAPC5/ATR/ANAPC4/MAU2/WEE1/CDC14B/MCM3/HDAC2/E2F4/CDKN1A/CUL1/CCND1/PPP2R5E/CDK7/ANAPC1/RBL1/E2F3/YWHAG/MCM5/PPP2R5C/CDKN1B/ORC2/GADD45A/CDC23/CDKN1C/GADD45G/CDC16/PPP2R1A/ORC5/TP53/CDC27/ABL1/RB1/DBF4B/CCND3/ORC4/RBL2/MYC/DDX11/E2F5/CDC7/PPP2R5A/FZR1/CDC14A/SMAD3/HDAC8/CCND2/ANAPC7/CCNH/CDKN2B/PPP2R5D/PPP2R1B/MTBP/TICRR/ZBTB17/SMC1B/CDC25A/ESPL1/ANAPC2	6.15072340463937
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	152/2885	333/9376	1.48344392919783	ITGA6/ITGB4/EGFR/LAMB1/ITGAV/LAMC1/LAMA5/ITGB1/COL4A2/CDK6/ITGB5/DLG1/ITGB8/CREB3L2/COL4A1/TCF7L2/MAML2/UBR4/ATP6AP1/ATP6V1B1/DVL3/JAG1/CHD4/KRAS/EP300/FZD5/PRKCI/RBPJ/PARD3/MDM2/FZD6/NOTCH3/MAML3/ATM/TLR3/PIK3R1/GSK3B/UBE3A/CREBBP/ATP6V0A1/FZD3/PIK3CA/PIK3R3/PTK2/MAGI1/PIK3CB/APC/ATP6V1H/ITGB6/PSEN1/SOS1/HES1/LAMB4/ATR/CSNK1A1/CASP3/ATP6V0B/FZD10/AKT3/LAMB2/RPS6KB1/PARD6B/PPP2R2A/NFKB1/CREB1/MTOR/EIF2AK2/HDAC2/CDKN1A/IFNAR1/CCND1/ATP6V1C2/AKT2/PTEN/PPP2R5E/PXN/FN1/MAML1/RBL1/SOS2/CTNNB1/WNT4/ITGA3/ATP6V1A/NOTCH2/IKBKB/BCAP31/DLG2/PPP2R5C/HLA-E/PPP2R3A/PPP2R2B/IRF3/RFNG/TSC2/PRKACB/TSC1/CDKN1B/MAPK1/PRKCZ/PPP2R3B/TCIRG1/PPP2R2D/HRAS/PPP2R1A/NFX1/TP53/JAK1/SCRIB/IFNAR2/WNT5A/AXIN2/RAF1/DLG3/RB1/ATP6V1E2/CCND3/ATP6V0A2/RBL2/STAT2/DVL1/ATP6V0A4/TBK1/CHUK/ATP6V1B2/TBP/WNT2B/CREB5/PPP2R5A/LAMA1/TYK2/PRKACA/THBS1/CCND2/FZD1/WNT3/TRAF3/FZD8/TCF7/VWF/DVL2/PPP2R5D/PPP2R1B/IKBKG/PARD6G/AXIN1/IKBKE/CREB3L4/TCF7L1/WNT7A/TUBG2/COL2A1	5.98845381810875
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	58/2885	98/9376	1.92341810207619	CDS1/ITPR2/SACM1L/PIK3R1/PIK3C2A/SYNJ1/PIP5K1A/PIK3CA/DGKH/PIK3R3/INPPL1/PIK3CB/PIKFYVE/PI4KA/DGKA/MTMR3/IP6K2/DGKD/PLCG2/PPIP5K2/CDIPT/IP6K1/PIP5K1B/PTEN/INPP1/INPP4A/INPP5F/PIP4K2B/PI4KB/PIK3C3/PLCB1/PLCE1/MTMR6/MTMR4/INPP5A/PI4K2A/PI4K2B/PIP5K1C/CDS2/PIK3C2B/SYNJ2/MTMR1/IPMK/DGKZ/IMPA1/PPIP5K1/PIP4K2C/ITPKC/OCRL/PRKCA/INPP5B/MTM1/ITPR1/INPP5E/IPPK/MTMR2/ITPK1/PLCG1	6.12614088284919
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	94/2885	184/9376	1.6602818174968	SEMA6A/MET/ITGB1/NRP1/SEMA6D/BMP7/EPHB4/RASA1/ROCK1/PLXNB1/SEMA3F/PLXNB2/KRAS/PLXNA1/CAMK2G/SEMA4B/BMPR2/SRGAP1/PARD3/LIMK2/EFNA5/ROCK2/NFATC3/PIK3R1/GSK3B/RYK/NTN4/EFNA1/ARHGEF12/SEMA7A/PDPK1/FZD3/PIK3CA/PPP3CA/PIK3R3/PTK2/PIK3CB/PLXNA2/PAK6/PTPN11/DPYSL2/PARD6B/PLCG2/GNAI1/SEMA4G/GNAI2/NFATC2/LRIG2/SEMA3E/NCK2/ROBO1/ENAH/EPHA2/NCK1/SEMA3C/WNT4/SSH2/SEMA4C/LRRC4/MAPK1/PRKCZ/ABLIM1/HRAS/SRGAP2/SEMA4D/RAC3/EFNB2/WNT5A/EPHB3/RAF1/ABL1/PTCH1/PPP3CB/SRGAP3/SSH1/PAK4/UNC5B/SSH3/EFNA4/PPP3CC/EPHB2/SEMA3A/PRKCA/NEO1/BOC/EPHA1/PARD6G/TRPC6/RGMA/PLXNA3/SRC/SEMA3G/NTN1/PLCG1	6.03025925808734
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	53/2885	87/9376	1.97983226757505	EGFR/FOS/JUN/PMAIP1/TCF7L2/GADD45B/KRAS/BCL2/TGFBR1/PIK3R1/GSK3B/TGFBR2/PIK3CA/SMAD2/SMAD4/PIK3R3/PIK3CB/APC/APPL1/SOS1/CASP3/AKT3/RPS6KB1/POLK/MTOR/CDKN1A/CCND1/AKT2/BRAF/MSH3/MSH6/MAPK8/SOS2/CTNNB1/GADD45A/MAPK1/GADD45G/HRAS/TP53/RAC3/BCL2L11/AXIN2/RAF1/MSH2/RALGDS/MYC/MLH1/ARAF/SMAD3/TCF7/AXIN1/TCF7L1/BBC3	6.12110211526862
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	55/2885	93/9376	1.92199176310542	ITGA6/LAMB1/ITGAV/LAMC1/LAMA5/ITGB1/COL4A2/CDK6/COL4A1/GADD45B/BCL2/PIK3R1/SKP2/XIAP/BIRC2/PIK3CA/PIK3R3/PTK2/PIK3CB/NFKBIA/LAMB4/CASP3/AKT3/RXRA/LAMB2/TRAF4/NFKB1/POLK/CDKN1A/CCND1/AKT2/PTEN/FN1/E2F3/ITGA3/IKBKB/CDKN1B/GADD45A/GADD45G/TP53/BCL2L1/TRAF5/FHIT/RB1/MAX/RXRB/CHUK/MYC/LAMA1/TRAF3/APAF1/CDKN2B/TRAF6/IKBKG/ZBTB17	5.95699290172162
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	82/2885	158/9376	1.68666388785293	CLIP1/SLC38A9/IGF1R/LRP5/SLC3A2/RICTOR/ATP6V1B1/DVL3/KRAS/FZD5/FZD6/PIK3R1/SKP2/GSK3B/LPIN2/PDPK1/FZD3/PIK3CA/INSR/PIK3R3/PIK3CB/ATP6V1H/SOS1/FZD10/AKT3/RPS6KB1/MTOR/RPS6KA3/ULK2/ATP6V1C2/FNIP2/AKT2/BRAF/PTEN/PRR5/RRAGC/CAB39/SESN2/FNIP1/SOS2/WNT4/ATP6V1A/LPIN1/IKBKB/TSC2/TSC1/MAPK1/LRP6/HRAS/NPRL3/MIOS/RRAGB/PRKAA1/WNT5A/RAF1/ATP6V1E2/WDR59/ULK1/DVL1/STRADB/RPTOR/CHUK/ATP6V1B2/WNT2B/TTI1/DEPDC5/STRADA/TELO2/SEH1L/FZD1/WNT3/GRB10/STK11/PRKCA/WDR24/FZD8/PRKAA2/IRS1/DVL2/FLCN/WNT7A/RPS6KA6	5.80306108471618
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	66/2885	122/9376	1.75814984231611	ITGAV/SLC2A1/NCOA3/SLC9A1/SLC16A2/ATP2A2/NCOR1/KRAS/ATP1A1/MED13/EP300/NCOA2/MDM2/NOTCH3/PIK3R1/GSK3B/SIN3A/NCOA1/CREBBP/PDPK1/PIK3CA/MED12L/MED16/MED13L/PIK3R3/MED12/PIK3CB/MED1/AKT3/RXRA/RCAN1/PLCG2/MTOR/HDAC2/BMP4/CCND1/AKT2/CTNNB1/WNT4/MED17/MED24/NOTCH2/THRB/ATP1B3/TSC2/PRKACB/MED14/KAT2B/MAPK1/PLCB1/HRAS/TP53/PLCE1/RAF1/RXRB/TBC1D4/HIF1A/MYC/ATP1A4/PRKACA/KAT2A/PRKCA/SRC/SLC16A10/PLCG1/PFKFB2	5.61918019386043
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	52/2885	90/9376	1.87772771037936	IGF1R/CREB3L2/RB1CC1/KRAS/ADCY7/CAT/PIK3R1/ATF6B/PIK3CA/IRS2/INSR/PIK3R3/PRKAB2/PIK3CB/APPL1/SESN1/AKT3/RPS6KB1/NFKB1/CREB1/MTOR/EHMT1/AKT2/FOXO3/SESN2/ADCY6/ADIPOR1/PPARG/ADCY2/ATF2/TSC2/PRKACB/TSC1/ADIPOR2/SESN3/HRAS/EHMT2/TP53/CAMKK2/PRKAA1/ULK1/RPTOR/SIRT1/CREB5/PRKACA/ATG13/ADCY9/STK11/PRKAA2/IRS1/PRKAB1/CREB3L4	5.57788385467209
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	88/2885	178/9376	1.60669873230386	LGR5/TLE4/LGR4/JUN/RNF43/TBL1X/LRP5/SERPINF1/ZNRF3/TCF7L2/DVL3/CAMK2G/EP300/FZD5/SIAH1/DAAM1/TLE1/FZD6/CHD8/ROCK2/TBL1XR1/NFATC3/FBXW11/NOTUM/GSK3B/RYK/CREBBP/FZD3/SMAD4/PPP3CA/APC/PSEN1/CSNK1A1/FZD10/CUL1/NFATC2/CCND1/MAPK8/APCDD1/CTNNB1/WNT4/TLE3/MAP3K7/PRKACB/CTBP1/CSNK2A1/PRICKLE1/PLCB1/LRP6/PPARD/TP53/RAC3/CTBP2/WNT5A/AXIN2/VANGL1/BTRC/NLK/CCND3/SENP2/DVL1/SIRT1/BAMBI/WNT2B/MYC/PPP3CB/CELSR2/CCAR2/PRICKLE2/LGR6/SMAD3/PRKACA/CCND2/FZD1/WNT3/INVS/PPP3CC/PRICKLE4/PRKCA/FZD8/LZTS2/TCF7/DVL2/FRAT2/AXIN1/ANKRD6/TCF7L1/WNT7A	5.44802545906624
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	39/2885	62/9376	2.04430032984849	TLE4/NCSTN/MAML2/DVL3/JAG1/EP300/RBPJ/SPEN/TLE1/NOTCH3/MAML3/ADAM17/CREBBP/DTX4/PSEN1/NUMB/HES1/HDAC2/ATXN1/ITCH/APH1A/MAML1/NOTCH2/TLE3/RFNG/CTBP1/KAT2B/PSEN2/CTBP2/ATXN1L/DVL1/DTX2/KAT2A/JAG2/DVL2/NCOR2/DTX3L/NUMBL/APH1B	5.49991383352807
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	66/2885	125/9376	1.71595424610052	ORMDL1/DEGS1/CTSD/ASAH1/GNA12/ROCK1/GNAQ/KRAS/BCL2/MAPK14/ROCK2/SMPD1/SGPP1/PIK3R1/S1PR2/SPTLC3/PDPK1/PIK3CA/SGMS1/PIK3R3/PIK3CB/S1PR3/AKT3/ORMDL3/PPP2R2A/NFKB1/CERS6/GNAI1/GNAI2/AKT2/PTEN/PPP2R5E/MAPK8/CERS2/PPP2R5C/PPP2R3A/PPP2R2B/NSMAF/GNA13/SPTLC2/MAPK1/SPTLC1/PRKCZ/CERS5/PPP2R3B/PLCB1/PPP2R2D/SGMS2/HRAS/PPP2R1A/TP53/RAC3/SGPL1/RAF1/PLD2/ABCC1/SPHK2/PPP2R5A/PLD1/PRKCA/PPP2R5D/PPP2R1B/GAB2/PRKCE/S1PR1/MAP3K5	5.37215676702767
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	69/2885	133/9376	1.68604526915208	EGFR/IGF1R/GADD45B/HOMER1/KRAS/EP300/TGFBR1/MDM2/MAPK14/CAT/ATM/PLK2/PIK3R1/SKP2/FOXO4/TGFBR2/CREBBP/PDPK1/PIK3CA/IRS2/INSR/SMAD4/PIK3R3/PRKAB2/PIK3CB/SETD7/USP7/G6PC3/SOS1/AKT3/STK4/CDKN1A/CCND1/AKT2/BRAF/PTEN/FOXO3/MAPK8/ATG12/SOS2/IKBKB/CCNG2/SGK3/CDKN1B/FBXO25/GADD45A/MAPK1/GADD45G/HRAS/GABARAPL1/PRKAA1/BCL2L11/STAT3/RAF1/NLK/RBL2/CHUK/SIRT1/FOXO6/ARAF/SMAD3/CCND2/STK11/PRKAA2/IRS1/CDKN2B/PRKAB1/S1PR1/TNFSF10	5.3122054150921
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	49/2885	86/9376	1.85169481278465	EGFR/JUN/GAB1/ERBB3/KRAS/CAMK2G/PIK3R1/GSK3B/PIK3CA/PIK3R3/PTK2/PIK3CB/PAK6/CBL/SOS1/AKT3/ERBB2/RPS6KB1/PLCG2/SHC1/MTOR/CDKN1A/NCK2/AKT2/BRAF/MAPK8/CRK/NCK1/SOS2/MAP2K4/CDKN1B/MAPK1/HRAS/MAP2K7/ABL2/ERBB4/CRKL/RAF1/ABL1/STAT5B/HBEGF/MYC/ARAF/PAK4/PRKCA/SRC/BTC/NRG4/PLCG1	5.2896643254861
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	37/2885	59/9376	2.03808125018359	CDH1/EGFR/TCF7L2/GADD45B/KRAS/PIK3R1/GSK3B/PDPK1/PIK3CA/PIK3R3/PIK3CB/APC/SOS1/AKT3/ERBB2/POLK/CDKN1A/CCND1/AKT2/BRAF/PTEN/FOXO3/SOS2/CTNNB1/GADD45A/MAPK1/GADD45G/HRAS/TP53/AXIN2/RAF1/MYC/MLH1/ARAF/TCF7/AXIN1/TCF7L1	5.33239174401668
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	78/2885	157/9376	1.61460662994403	CDH1/DLG5/BMP7/FRMD6/RASSF6/DLG1/TEAD1/AMOT/TCF7L2/LATS2/DVL3/FZD5/PRKCI/TGFBR1/BMPR2/PARD3/FZD6/ID2/YAP1/FBXW11/GSK3B/BMPR1A/TGFBR2/BIRC2/FZD3/SMAD2/SMAD4/WWC1/APC/SAV1/FZD10/PARD6B/PPP2R2A/TEAD3/BMP4/LATS1/CCND1/ID1/WWTR1/YWHAG/TP53BP2/CTNNB1/WNT4/DLG2/PPP2R2B/PRKCZ/CSNK1D/MOB1B/PPP2R2D/SMAD7/PPP2R1A/SCRIB/WNT5A/AXIN2/BTRC/DLG3/LIMD1/CCND3/SMAD1/DVL1/WNT2B/MYC/AJUBA/SMAD3/CCND2/FZD1/WNT3/NF2/FZD8/TCF7/DVL2/PPP2R1B/PARD6G/WTIP/AXIN1/TCF7L1/WNT7A/BBC3	5.17735449063355
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	96/2885	204/9376	1.52937098582934	EGFR/ITGAV/MET/ITGB1/IQGAP1/ITGB5/IGF1R/ROCK1/ANK3/SLC9A1/GAB1/ERBB3/ITPR2/CTSL/DDX5/TIMP3/GPC1/PPP1R12A/KRAS/CAMK2G/FZD5/GPC3/MDM2/FZD6/MAPK14/ROCK2/RDX/VAV3/PPP1R12B/PIK3R1/ARHGEF12/PDPK1/FZD3/PIK3CA/SMAD2/PIK3R3/PTK2/PIK3CB/CBL/FRS2/PTPN11/SOS1/CASP3/FZD10/AKT3/ERBB2/RPS6KB1/PLCG2/MTOR/CDKN1A/CCND1/AKT2/BRAF/PXN/FN1/TIAM1/SOS2/MRAS/HCLS1/CTNNB1/WNT4/PRKACB/MAPK1/HRAS/TP53/PLCE1/DROSHA/WNT5A/ERBB4/STAT3/RAF1/PTCH1/PLAU/HBEGF/HSPG2/CTTN/HIF1A/FGFR1/NUDT16L1/WNT2B/MYC/ARAF/PRKACA/THBS1/FZD1/WNT3/TWIST1/PRKCA/FZD8/ITPR1/PTPN6/SRC/ANK1/WNT7A/FGF2/PLCG1	5.09619382792362
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	57/2885	106/9376	1.74759491187339	EGFR/SPINT1/SLC19A1/IGF1R/HSP90B1/CREB3L2/TCF7L2/KRAS/FOLR1/EP300/FGFR2/BCL2/MDM2/PIK3R1/GSK3B/PDGFD/CREBBP/PDPK1/PIK3CA/PIK3R3/PIK3CB/NFKBIA/SOS1/AKT3/ERBB2/NFKB1/CREB1/SLC46A1/MTOR/CDKN1A/CCND1/AKT2/BRAF/PTEN/SOS2/E2F3/CTNNB1/IKBKB/CDKN1B/MAPK1/HRAS/TP53/ETV5/PDGFB/RAF1/RB1/PLAU/PDGFA/CHUK/PDGFC/FGFR1/CREB5/ARAF/TCF7/IKBKG/CREB3L4/TCF7L1	5.16038548334649
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	70/2885	138/9376	1.64850676914576	PTPRF/PHKB/SORBS1/KRAS/FLOT2/PRKCI/RAPGEF1/FASN/PIK3R1/GSK3B/PDPK1/PIK3CA/IRS2/INSR/PIK3R3/INPPL1/PRKAB2/PIK3CB/PDE3B/CBL/G6PC3/SOCS1/SOS1/PRKAR2A/ACACA/AKT3/RPS6KB1/PTPN1/SHC1/MTOR/PHKA2/AKT2/BRAF/RHOQ/MAPK8/CRK/SOS2/SOCS4/IKBKB/TSC2/PRKACB/TSC1/MAPK1/PRKCZ/HRAS/EXOC7/PRKAR1A/PRKAA1/SOCS2/PPP1R3D/INPP5A/CRKL/PPP1R3E/RAF1/MKNK2/MKNK1/RPTOR/PYGB/SREBF1/ARAF/PHKG2/PRKACA/PRKAA2/IRS1/PHKA1/PPP1R3B/PRKAB1/PHKG1/PPP1R3F/PRKAR1B	5.11643923061931
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	63/2885	122/9376	1.67823394039265	IGF1R/CREB3L2/HMGCR/FASN/PIK3R1/CPT1A/PDPK1/PIK3CA/IRS2/INSR/PIK3R3/PRKAB2/PIK3CB/G6PC3/ACACA/AKT3/RPS6KB1/PPP2R2A/CREB1/MTOR/CCND1/AKT2/PPP2R5E/FOXO3/CAB39/ADIPOR1/RAB14/PPARG/PPP2R5C/PPP2R3A/PPP2R2B/MAP3K7/RAB10/TSC2/TSC1/ADIPOR2/PPP2R3B/PPP2R2D/PPP2R1A/PFKFB4/CAMKK2/PRKAA1/TBC1D1/ULK1/EEF2K/STRADB/RPTOR/SIRT1/CREB5/MLYCD/SREBF1/PPP2R5A/STRADA/SCD5/STK11/PRKAA2/IRS1/PPP2R5D/PPP2R1B/PRKAB1/CREB3L4/CRTC2/PFKFB2	5.02686739736767
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	51/2885	93/9376	1.78221054397048	CDH1/EGFR/MET/IQGAP1/CTNND1/PTPRF/IGF1R/ACTN4/ROCK1/LMO7/TCF7L2/SORBS1/WASF2/VCL/TJP1/EP300/TGFBR1/PTPRM/PARD3/ROCK2/TGFBR2/KRIT1/CREBBP/YES1/BAIAP2/INSR/SMAD4/WASL/ARHGAP29/SMURF2/ERBB2/PTPN1/ACTN1/CTNNB1/MAP3K7/PTPRJ/CSNK2A1/MAPK1/RAC3/NLK/FARP2/FER/FGFR1/SMURF1/SMAD3/WASF1/TCF7/CDH5/PTPN6/SRC/TCF7L1	5.0538658202212
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	56/2885	105/9376	1.73328711727325	JUN/HUWE1/KRAS/SIAH1/USP8/ATG9A/AMFR/NBR1/RAB5B/ARIH1/CITED2/SMURF2/SP1/MON1B/RHOT1/OPTN/TBC1D15/BCL2L13/FOXO3/MAPK8/MUL1/OPA1/MRAS/MTX3/RAB7B/VCP/CSNK2A1/HRAS/USP15/TP53/GABARAPL1/BCL2L1/EIF2AK3/MFN2/TFEB/PINK1/TOMM20/TFE3/ATG9B/BECN1/ULK1/TBC1D17/HIF1A/TBK1/RHOT2/FUNDC1/MFN1/NLRX1/SMURF1/USP30/CCZ1B/RABGEF1/SRC/AMBRA1/TOMM40L/MON1A	5.03741993554939
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	44/2885	77/9376	1.85709333993563	EGFR/CDK6/GADD45B/KRAS/TGFBR1/PIK3R1/TGFBR2/BRCA2/PIK3CA/SMAD2/SMAD4/PIK3R3/PIK3CB/AKT3/ERBB2/RPS6KB1/RALBP1/NFKB1/POLK/MTOR/CDKN1A/CCND1/AKT2/BRAF/MAPK8/E2F3/IKBKB/GADD45A/MAPK1/GADD45G/TP53/JAK1/BCL2L1/RAC3/STAT3/RAF1/RB1/PLD2/RALGDS/CHUK/PLD1/ARAF/SMAD3/IKBKG	5.03452036014704
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	73/2885	148/9376	1.60299779849173	EGFR/FOS/NCOA3/JUN/CDK6/IGF1R/LRP5/TCF7L2/GADD45B/DVL3/JAG1/KRAS/FZD5/FZD6/NOTCH3/PIK3R1/GSK3B/NCOA1/BRCA2/FZD3/PIK3CA/PIK3R3/PIK3CB/APC/SOS1/HES1/CSNK1A1/FZD10/AKT3/ERBB2/RPS6KB1/POLK/SHC1/MTOR/SP1/CDKN1A/CCND1/AKT2/BRAF/PTEN/SOS2/E2F3/CTNNB1/WNT4/NOTCH2/BRCA1/GADD45A/MAPK1/GADD45G/LRP6/HRAS/TP53/WNT5A/AXIN2/RAF1/RB1/DVL1/FGFR1/WNT2B/MYC/ARAF/FZD1/WNT3/FZD8/TCF7/JAG2/ESR2/DVL2/FRAT2/AXIN1/TCF7L1/WNT7A/FGF2	4.92941671871619
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	34/2885	55/9376	2.00903734047582	PLPP3/PSAP/DEGS1/HEXA/ASAH1/HEXB/GLB1/B4GALT5/GM2A/SMPD1/SGPP1/SPTLC3/NEU1/KDSR/SGMS1/CERS6/GLA/CERS2/SMPD4/ACER3/GBA2/SAMD8/GALC/SPTLC2/SPTLC1/CERS5/UGCG/SGMS2/SGPL1/ARSA/SPHK2/NEU3/CERK/B4GALT6	5.00334063359183
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	71/2885	144/9376	1.60238782977085	IL6ST/ZFHX3/IGF1R/RIF1/LIFR/TBX3/DVL3/KRAS/JARID2/FZD5/FGFR2/REST/SMAD5/BMPR2/FZD6/ISL1/MAPK14/ID2/PIK3R1/GSK3B/BMPR1A/KAT6A/FZD3/PIK3CA/SMAD2/SMAD4/PIK3R3/PIK3CB/APC/ACVR2B/SMARCAD1/ID4/ACVR2A/FZD10/AKT3/BMP4/AKT2/ID1/BMI1/CTNNB1/WNT4/MAPK1/HRAS/JAK1/SETDB1/PCGF3/ACVR1/WNT5A/STAT3/AXIN2/RAF1/DUSP9/SMAD1/DVL1/FGFR1/WNT2B/MYC/KLF4/MEIS1/SMAD3/FZD1/WNT3/FZD8/TCF7/ACVR1C/DVL2/SKIL/AXIN1/JAK2/WNT7A/FGF2	4.85637572532521
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	73/2885	150/9376	1.58162449451184	CDH1/EGFR/MET/LRP5/TCF7L2/GADD45B/GAB1/ABCB1/DVL3/KRAS/FZD5/FGFR2/BCL2/TGFBR1/FZD6/PIK3R1/GSK3B/TGFBR2/FZD3/PIK3CA/SMAD2/SMAD4/PIK3R3/PIK3CB/APC/SOS1/CSNK1A1/FZD10/AKT3/ERBB2/RXRA/RPS6KB1/POLK/SHC1/MTOR/CDKN1A/JUP/CCND1/AKT2/BRAF/SOS2/E2F3/CTNNB1/WNT4/CDKN1B/GADD45A/MAPK1/GADD45G/LRP6/HRAS/TP53/WNT5A/AXIN2/RAF1/RB1/DVL1/RXRB/WNT2B/MYC/MLH1/ARAF/SMAD3/FZD1/WNT3/FZD8/CDKN2B/TCF7/DVL2/FRAT2/AXIN1/TCF7L1/WNT7A/FGF2	4.78723045669849
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	34/2885	56/9376	1.9731616736816	LRP2/GLI3/BCL2/FBXW11/GSK3B/PTCH2/SMURF2/CSNK1A1/CUL1/CCND1/GAS1/KIF3A/MGRN1/PRKACB/CSNK1G3/CSNK1D/CUL3/SPOP/BTRC/PTCH1/MEGF8/SPOPL/CSNK1G1/ARRB1/SMURF1/HHAT/SUFU/PRKACA/CCND2/IQCE/BOC/EFCAB7/DISP1/EVC2	4.86938144316572
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	52/2885	99/9376	1.70702519125396	EGFR/PLPP3/FOS/JUN/WASF2/SLC44A2/KRAS/SLC44A1/PIK3R1/SLC22A5/GPCPD1/CHPT1/PDGFD/PIP5K1A/PDPK1/SLC44A5/PIK3CA/DGKH/PIK3R3/LYPLA1/PIK3CB/SOS1/DGKA/AKT3/RPS6KB1/DGKD/MTOR/SP1/PIP5K1B/AKT2/MAPK8/SOS2/TSC2/TSC1/MAPK1/HRAS/RAC3/PDGFB/RAF1/PIP5K1C/PLD2/PDGFA/RALGDS/HIF1A/PDGFC/SLC44A3/DGKZ/PLD1/WASF1/PRKCA/PCYT1A/PLCG1	4.7146716211264
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	28/2885	44/9376	2.06812667401922	RPN2/TUSC3/HEXA/HEXB/B4GALT1/MAN1A2/FUT8/STT3B/MAN2A1/DDOST/RPN1/STT3A/MAGT1/MAN2A2/MAN1B1/MAN1A1/MAN1C1/ALG2/MGAT1/ALG11/MGAT2/ALG1/ALG14/ALG9/ALG12/MGAT4A/B4GALT3/ST3GAL3	4.73439485955754
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	21/2885	30/9376	2.27493934142114	PGAP1/GPAA1/PIGS/PIGT/PIGM/PIGG/PGAP2/PIGO/PIGU/MPPE1/PIGK/PIGX/PIGV/PIGN/PIGQ/PIGC/PIGL/B3GALT4/PIGB/PGAP3/PIGW	4.66272716592488
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	36/2885	63/9376	1.85709333993563	KMT2C/ASH1L/HADHA/NSD1/SETD2/KMT2A/PRDM2/PLOD1/DHTKD1/PLOD2/SETD7/KMT2B/SMYD2/EHMT1/KMT2E/PLOD3/KMT5B/KMT2D/SETD1B/EZH1/EHMT2/SETDB1/PHYKPL/SETDB2/KMT5A/EZH2/AASS/EHHADH/SETMAR/SETD1A/KMT5C/DOT1L/DLST/COLGALT1/GCDH/TMLHE	4.55047084368486
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	51/2885	99/9376	1.67419778372985	EGFR/FOS/NCOA3/JUN/IGF1R/NCOR1/JAG1/KRAS/BCL2/MDM2/ADCY7/MAPK14/NOTCH3/PIK3R1/PIK3CA/PIK3R3/PTK2/PIK3CB/SOS1/MED1/AKT3/ERBB2/RPS6KB1/SHC1/MTOR/SP1/CDKN1A/CCND1/AKT2/BRAF/MAPK8/SOS2/E2F3/ADCY6/NOTCH2/ADCY2/PRKACB/CDKN1B/MAPK1/HRAS/TP53/RAF1/RB1/CARM1/HBEGF/ARAF/PRKACA/ADCY9/JAG2/ESR2/SRC	4.49576789808564
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	55/2885	109/9376	1.63986453182389	SLC2A1/SLC27A2/PTPRF/CREB3L2/PIK3R1/GSK3B/GFPT1/CPT1A/PDPK1/PIK3CA/IRS2/INSR/OGT/PIK3R3/PRKAB2/PIK3CB/NFKBIA/PTPN11/G6PC3/AKT3/SLC27A6/RPS6KB1/PTPN1/NFKB1/CREB1/MTOR/RPS6KA3/AKT2/PTEN/MAPK8/SLC27A3/IKBKB/PPARA/PRKCZ/PRKAA1/PPARGC1B/PPP1R3D/STAT3/PPP1R3E/TBC1D4/PYGB/SLC27A4/CREB5/SREBF1/MLXIP/PRKAA2/IRS1/PPP1R3B/PRKAB1/PRKCE/CREB3L4/NR1H3/RPS6KA6/CRTC2/SLC27A1	4.4795506077989
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	76/2885	163/9376	1.51529701970208	FOS/JUN/DDB1/CREB3L2/ATP6AP1/KRAS/EP300/BCL2/TGFBR1/MAPK14/MAP3K1/NFATC3/TLR3/PIK3R1/TGFBR2/ATF6B/CREBBP/PIK3CA/MAVS/SMAD4/PIK3R3/PIK3CB/DDX3X/TAB2/NFKBIA/SOS1/CASP3/AKT3/NFKB1/CREB1/CDKN1A/NFATC2/IFNAR1/AKT2/BRAF/MAPK8/SOS2/E2F3/IKBKB/ATF2/IRF3/MAP3K7/MAP2K4/MAPK1/HRAS/MAP2K7/TP53/JAK1/STAT3/RAF1/RB1/STAT5B/IFIH1/IRAK4/STAT2/HSPG2/TAB1/TBK1/CHUK/MYC/CREB5/TYK2/ARAF/SMAD3/MYD88/MAP2K6/TRAF3/APAF1/PRKCA/TRAF6/IKBKG/IKBKE/JAK2/SRC/CREB3L4/TIRAP	4.42439242054375
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	43/2885	80/9376	1.74682842287695	EGFR/MET/NF1/IGF1R/GAB1/ERBB3/KRAS/FGFR2/BCL2/PIK3R1/GSK3B/PDGFD/PIK3CA/PIK3R3/PIK3CB/SOS1/AKT3/ERBB2/RPS6KB1/PLCG2/SHC1/MTOR/AKT2/BRAF/PTEN/FOXO3/SOS2/MAPK1/HRAS/JAK1/BCL2L1/PDGFB/BCL2L11/STAT3/RAF1/PDGFA/PDGFC/ARAF/PRKCA/JAK2/SRC/FGF2/PLCG1	4.47219278237032
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	40/2885	73/9376	1.78077443555471	EGFR/MET/CDK6/EML4/KIF5B/GADD45B/KRAS/PIK3R1/PDPK1/PIK3CA/PIK3R3/PIK3CB/SOS1/AKT3/ERBB2/RXRA/STK4/PLCG2/POLK/CDKN1A/CCND1/AKT2/BRAF/FOXO3/SOS2/E2F3/GADD45A/MAPK1/GADD45G/HRAS/TP53/FHIT/STAT3/RAF1/RB1/STAT5B/RXRB/ARAF/PRKCA/PLCG1	4.46455571427269
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	55/2885	110/9376	1.62495667244367	FBN1/TFRC/BMP7/ROCK1/LTBP1/ZFYVE16/NCOR1/EP300/SMAD5/TGFBR1/BMPR2/ID2/SIN3A/BMPR1A/TGFBR2/CREBBP/SMAD2/SMAD4/ACVR2B/ID4/SMURF2/ACVR2A/ZFYVE9/LEMD3/RPS6KB1/HDAC2/BMP4/SP1/E2F4/CUL1/ID1/RBL1/MAPK1/SMAD7/PPP2R1A/SKI/ACVR1/THSD4/RGMB/SMAD1/BAMBI/MYC/SMURF1/E2F5/SMAD3/THBS1/TGIF2/NEO1/CDKN2B/ACVR1C/PPP2R1B/SKIL/RGMA/HFE/PITX2	4.3954449609204
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	33/2885	57/9376	1.88152877861899	HACD3/HADHA/ACSL3/CPT2/FASN/CPT1A/PPT1/HSD17B12/ELOVL4/ACACA/ACOX1/HACD2/ELOVL1/ACADS/ACADVL/ACSL4/ACADL/PPT2/TECR/ACADSB/ACADM/ACSL1/CBR4/EHHADH/FADS1/HACD4/SCD5/ELOVL5/OXSM/ACSL5/ACSF3/ELOVL7/ELOVL6	4.4503278830509
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	52/2885	103/9376	1.64073295081691	MSI2/FUS/PNN/UPF2/SMG1/PABPN1/UPF3A/WDR82/CPSF2/UPF1/RNMT/DDX39B/PCF11/PABPC1/SYMPK/SMG6/CPSF7/PPP2R2A/GSPT2/CASC3/NXF1/UPF3B/SMG7/PPP2R5E/DDX19A/PABPC4/TARDBP/SMG5/SRRM1/ACIN1/WDR33/FIP1L1/NCBP1/PPP2R5C/PPP2R3A/PPP2R2B/PPP2R3B/RNPS1/PPP2R2D/PPP2R1A/CSTF3/PAPOLG/PAPOLA/RNGTT/PABPC1L/CSTF1/PPP2R5A/CPSF1/CSTF2T/GLE1/PPP2R5D/PPP2R1B	4.35901419978398
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	73/2885	157/9376	1.51110620494762	CDK6/ZFP36L1/GADD45B/ITPR2/RAD50/TRPM7/KRAS/TGFBR1/MDM2/HIPK2/MAPK14/ATM/NFATC3/FBXW11/PIK3R1/TGFBR2/PIK3CA/SMAD2/PPP3CA/PIK3R3/PIK3CB/HIPK1/ATR/AKT3/HIPK3/NFKB1/MTOR/E2F4/CDKN1A/NFATC2/CCND1/AKT2/TRPV4/PTEN/FOXO3/RBBP4/RBL1/E2F3/MRAS/HLA-E/CAPN1/TSC2/TSC1/RAD9A/GADD45A/MAPK1/GADD45G/LIN9/HRAS/TP53/NBN/BTRC/RAF1/RB1/CCND3/RBL2/SIRT1/MCU/MYC/PPP3CB/LIN54/E2F5/SMAD3/MAPKAPK2/CCND2/LIN52/MAP2K6/PPP3CC/CAPN2/CDKN2B/ITPR1/TRAF3IP2/CDC25A	4.3054823629501
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	16/2885	21/9376	2.4761244532475	CHPF/DSE/XYLT1/CHST12/B3GAT3/CHST11/CHST14/CHSY1/CHPF2/B4GALT7/XYLT2/CHST3/UST/B3GALT6/DSEL/CSGALNACT2	4.51453961788178
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	65/2885	137/9376	1.54192968918013	FOS/CTSC/JUN/CTSD/PMAIP1/CTSV/GADD45B/ITPR2/SPTAN1/CTSL/KRAS/CTSO/BCL2/CFLAR/CTSF/ATM/PARP1/PIK3R1/MCL1/XIAP/PDPK1/BIRC2/PIK3CA/DDIT3/CTSB/PIK3R3/PIK3CB/NFKBIA/CASP3/AKT3/NFKB1/AKT2/CASP2/MAPK8/IKBKB/CAPN1/CTSZ/AIFM1/GADD45A/MAPK1/DFFA/GADD45G/HRAS/TP53/BCL2L1/EIF2AK3/PARP2/ERN1/RIPK1/BCL2L11/PIDD1/RAF1/CHUK/DAXX/TNFRSF10B/NOL3/DFFB/CAPN2/APAF1/PARP4/ITPR1/IKBKG/TNFSF10/BBC3/MAP3K5	4.25984195460455
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	125/2885	300/9376	1.35413056036973	EGFR/MET/FOS/JUN/NF1/RASA1/IGF1R/GNA12/DUSP6/DUSP1/MAP3K4/GADD45B/RPS6KA5/ERBB3/JUND/TAOK1/KRAS/FGFR2/TGFBR1/TAOK3/MAPK14/EFNA5/MAP3K2/MAP3K1/GNG12/NFATC3/RAPGEF2/EFNA1/TGFBR2/PDGFD/MAP4K4/DDIT3/INSR/PPP3CA/RASA2/TAB2/MAP4K3/SOS1/HSPA1B/CASP3/AKT3/ELK4/ERBB2/HSPA8/STK4/NFKB1/RPS6KA3/AKT2/BRAF/PPM1B/HSPA1A/MAPK8/EPHA2/CRK/NR4A1/SOS2/MRAS/DUSP16/IKBKB/ATF2/MAP3K7/PRKACB/ANGPT1/MAP2K4/GADD45A/MAPK1/MAPKAPK5/GADD45G/HRAS/MAP2K7/TP53/PPM1A/RAC3/PDGFB/ERBB4/CRKL/RAF1/NLK/IRAK4/MKNK2/DUSP9/MKNK1/MAP3K11/MAX/PDGFA/TAB1/ARRB1/CHUK/BDNF/PDGFC/DAXX/MAP3K3/FGFR1/RPS6KA4/TAOK2/MYC/PPP3CB/MAPK8IP3/PPP5C/ARAF/PRKACA/MAPKAPK2/MYD88/MAP2K6/SRF/MAP3K9/EFNA4/PPP3CC/MAP3K12/PRKCA/TRAF6/IKBKG/MAPK7/PGF/IL1R1/MAP4K2/MAP2K5/NTF4/RPS6KA6/MAP3K10/MAPK8IP1/MAPK8IP2/CACNA2D3/FGF2/MAP3K5	4.15603821989434
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	65/2885	138/9376	1.53075628563535	ITGB1/FOS/JUN/PKN2/ROCK1/GNAQ/WASF2/MAPK14/ROCK2/VAV3/NFATC3/PIK3R1/GSK3B/WIPF2/ARHGEF12/PIP5K1A/DOCK1/PIK3CA/BAIAP2/PIK3R3/PTK2/PIK3CB/WASL/TAB2/NFKBIA/ACTR2/AKT3/ARHGEF7/GIT2/NFKB1/RPS6KA3/NFATC2/PIP5K1B/AKT2/MAPK8/CRK/PXN/FN1/IKBKB/IRF3/MAP3K7/MAP2K4/MAPK1/MAP2K7/RAC3/BCAR1/CRKL/IRAK4/PIP5K1C/SKAP2/ACTR3C/TAB1/TBK1/CHUK/MYD88/MAP2K6/ELMO2/PYCARD/TRAF6/IKBKG/SRC/LAT/ACTR3B/RPS6KA6/PLCG1	4.18743860653847
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	40/2885	75/9376	1.73328711727325	PMAIP1/BCL2/TOP2B/MDM2/REV3L/ATM/PIK3R1/XIAP/PDPK1/BIRC2/PIK3CA/MGST3/ATP7B/PIK3R3/PIK3CB/CASP3/AKT3/ERBB2/MGST2/CDKN1A/AKT2/MSH3/MSH6/SLC31A1/BRCA1/MAPK1/TP53/BCL2L1/XPA/MSH2/ATP7A/GSTM3/MLH1/POLH/GSTM2/APAF1/ABCC2/GSTO2/BBC3/MAP3K5	4.25052531501373
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	40/2885	75/9376	1.73328711727325	CDK6/PMAIP1/GADD45B/MDM4/SIAH1/BCL2/MDM2/ATM/STEAP3/ZMAT3/PPP1R13L/PERP/SESN1/ATR/CASP3/SHISA5/RRM2B/CDKN1A/CCND1/PTEN/SESN2/EI24/CCNG2/TSC2/ZNF385A/GADD45A/GADD45G/SESN3/TP53/BCL2L1/PIDD1/PPM1D/CCND3/TNFRSF10B/THBS1/CCND2/CD82/APAF1/GORAB/BBC3	4.25052531501373
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	58/2885	120/9376	1.57079145002889	JUN/MAGED1/KIDINS220/RPS6KA5/GAB1/KRAS/CAMK2G/BCL2/MAPK14/MAP3K1/RAPGEF1/PIK3R1/GSK3B/SORT1/PDPK1/PIK3CA/PIK3R3/PIK3CB/FRS2/NFKBIA/PTPN11/PSEN1/SOS1/AKT3/NFKB1/PLCG2/SHC1/RPS6KA3/AKT2/BRAF/FOXO3/MAPK8/CRK/SOS2/IKBKB/MAPK1/HRAS/PSEN2/MAP2K7/TP53/SH2B1/CRKL/RAF1/ABL1/IRAK4/PRDM4/BDNF/MAP3K3/MAPKAPK2/IRS1/TRAF6/MAPK7/ZNF274/MAP2K5/NTF4/RPS6KA6/PLCG1/MAP3K5	4.19526261098615
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	56/2885	115/9376	1.58256649837993	EGFR/FOS/LRP5/GNA12/CREB3L2/AKAP13/GNAQ/ITPR2/JUND/WNK1/PDE4B/EGR1/MMP15/GATA3/MMP14/BCL2/ADCY7/ATF6B/WNK2/RXRA/CREB1/GNAI1/SP1/CDKN1A/GNAI2/BRAF/GNA11/ADCY6/MEF2A/SLC34A2/ADCY2/ATF2/PRKACB/GNA13/MAPK1/PLCB1/LRP6/RAF1/ARHGEF11/PLD2/HBEGF/RXRB/ARRB1/PDE4D/FGFR1/CREB5/PLD1/ARAF/MAFB/PRKACA/ADCY9/PRKCA/WNK3/ITPR1/MEF2D/CREB3L4	4.19052297935763
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	72/2885	157/9376	1.49040611994834	LRP1/ITGAV/SLC2A1/PBX1/ITGB5/ANO6/CD47/DNMT3A/ABCA1/CALR/ATP2A2/TMEM30A/ADAM10/CAMK2G/BSG/SLC16A1/MAPK14/LIPA/NFATC3/TMEM30B/ADAM17/ATP11B/CPT1A/DOCK1/RAB5B/PTK2/TGFBRAP1/P2RY6/PLA2G15/PTPN11/ADAM9/SIRPA/CASP3/RXRA/CREB1/VPS8/NFATC2/XKR8/CRK/ARNT/DUSP16/VPS39/RAB14/PPARG/RAB7B/MAPK1/PPARD/GULP1/BCAR1/ATP11C/VPS41/CRKL/VPS11/HIF1A/SIRT1/SPHK2/THBS1/MAPKAPK2/PANX1/VPS33A/VPS18/PTPN6/MERTK/JAK2/MFGE8/PLA2G6/S1PR1/NR1H3/TYRO3/P2RY2/AGER/VPS16	4.13110793741341
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	38/2885	71/9376	1.73939024092562	EGFR/MET/JUN/ATP6AP1/ADAM10/JAM3/ATP6V1B1/TJP1/F11R/MAPK14/ADAM17/ATP6V0A1/ATP6V1H/NFKBIA/PTPN11/CASP3/ATP6V0B/NFKB1/PLCG2/ATP6V1C2/MAPK8/ATP6V1A/IKBKB/MAP2K4/TCIRG1/ATP6V1E2/ATP6V0A2/HBEGF/ATP6V0A4/CHUK/ATP6V1B2/GIT1/PTPRZ1/IKBKG/NOD1/SRC/CXCR2/PLCG1	4.16914924557909
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	51/2885	104/9376	1.59370750566591	PLPP3/PISD/CDS1/PLD3/GPD1L/LPCAT3/GPCPD1/PTDSS1/CHPT1/LPIN2/ETNK1/AGPAT1/DGKH/SGMS1/LYPLA1/GPAM/PLA2G15/MBOAT7/DGKA/DGKD/AGPAT3/CDIPT/CEPT1/GPAT4/PLPP5/LPIN1/PNPLA6/SAMD8/GNPAT/GPD2/MBOAT2/PTDSS2/SGMS2/PCYT2/PLA2G12A/LCAT/CDS2/PLD2/AGPAT4/LCLAT1/PGS1/GDPD5/PEMT/DGKZ/PLD1/PCYT1A/AGPAT5/LPGAT1/ACHE/PLA2G6/ADPRM	4.05887091764738
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	58/2885	122/9376	1.54504077052021	FOS/CREB3L2/GNAQ/ITPR2/KRAS/EP300/ADCY7/MAPK14/MAP3K1/PIK3R1/GSK3B/ATF6B/CREBBP/GHR/PIK3CA/IRS2/PIK3R3/PTK2/PIK3CB/SOCS1/SOS1/AKT3/PLCG2/CREB1/SHC1/MTOR/GNAI1/GNAI2/AKT2/MAPK8/GNA11/CRK/SOS2/ADCY6/ADCY2/ATF2/JUNB/PRKACB/MAP2K4/MAPK1/PLCB1/HRAS/BCAR1/SOCS2/STAT3/CRKL/RAF1/STAT5B/CREB5/PRKACA/MAP2K6/ADCY9/PRKCA/IRS1/ITPR1/JAK2/CREB3L4/PLCG1	4.03967940321308
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	23/2885	37/9376	2.02021640357862	CDH1/TPR/TCF7L2/GADD45B/KRAS/NCOA4/RXRA/POLK/CDKN1A/CCND1/BRAF/CTNNB1/PPARG/CCDC6/GADD45A/MAPK1/GADD45G/HRAS/TP53/RXRB/MYC/TCF7/TCF7L1	4.14520218857311
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	76/2885	170/9376	1.45290243653787	ITGB1/MYH10/JUN/CLDN4/ACTN4/DLG1/AMOT/ROCK1/JAM3/TJP1/MARVELD3/PRKCI/F11R/PARD3/ROCK2/AMOTL1/RDX/MAP3K1/RAPGEF2/NEDD4/OCLN/MARVELD2/TJP2/MAGI1/PRKAB2/AMOTL2/ACTR2/SYMPK/MPDZ/ERBB2/PARD6B/PPP2R2A/NEDD4L/CCND1/ARHGAP17/MAPK8/MYH9/TIAM1/ACTN1/HCLS1/DLG2/SYNPO/PPP2R2B/PRKACB/RAP2C/PRKCZ/PPP2R2D/RAPGEF6/PPP2R1A/MAP2K7/SCRIB/PRKAA1/DLG3/WHAMM/EPB41L4B/TJAP1/CTTN/ACTR3C/CLDN19/CLDN12/CLDN3/PRKACA/NF2/STK11/CGN/CLDN1/PRKAA2/CLDN23/TJP3/PPP2R1B/PARD6G/PRKAB1/PRKCE/SRC/ACTR3B/MAP3K5	3.97279700594972
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	28/2885	49/9376	1.85709333993563	GALNT11/C1GALT1/B4GALT1/GXYLT1/GALNT1/GALNT18/OGT/GALNT6/C1GALT1C1/FUT10/POGLUT1/GALNT7/XXYLT1/POFUT1/PLOD3/RFNG/POFUT2/POMT1/GALNT12/POMT2/FUT11/GALNT3/GALNT2/B4GALT3/COLGALT1/EOGT/ST3GAL3/GALNT10	4.01012503846502
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	98/2885	232/9376	1.37280822327138	ITGA6/ITGB4/EGFR/ITGAV/IQGAP2/ITGB1/MYH10/IQGAP1/ITGB5/SCIN/DIAPH2/ACTN4/ITGB8/GNA12/ROCK1/SLC9A1/WASF2/VCL/PPP1R12A/KRAS/FGFR2/DIAPH1/NCKAP1/LIMK2/ROCK2/RDX/VAV3/GNG12/PPP1R12B/PIK3R1/ARHGEF12/PDGFD/PIP5K1A/DOCK1/PIK3CA/CYFIP2/CYFIP1/ABI2/BAIAP2/PIK3R3/PTK2/PIK3CB/WASL/APC/PAK6/ACTR2/ITGB6/PIKFYVE/SOS1/PFN2/AKT3/ARHGEF7/PIP5K1B/AKT2/BRAF/ENAH/MYH9/CRK/PXN/FN1/TIAM1/SOS2/ACTN1/MRAS/MYLK3/ITGA3/SSH2/ARHGAP35/GNA13/PIP4K2B/MAPK1/HRAS/RAC3/GSN/BCAR1/PDGFB/CRKL/RAF1/PIP5K1C/ACTR3C/PDGFA/DIAPH3/PDGFC/FGFR1/GIT1/ARAF/SSH1/PAK4/PIP4K2C/LPAR1/WASF1/SSH3/CHRM5/SRC/CHRM3/ACTR3B/FGF2/MYLK4	3.83322321277737
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	14/2885	19/9376	2.39467299096962	HEXA/GNS/HEXB/GLB1/GUSB/HGSNAT/NAGLU/SGSH/IDS/HYAL2/ARSB/GALNS/HYAL4/SPAM1	4.05680019691118
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	21/2885	34/9376	2.00729941890101	BHLHE41/FBXW11/CLOCK/PRKAB2/NR1D2/FBXL3/CREB1/CUL1/CSNK1D/PER3/PRKAA1/BTRC/DBP/CRY2/PRKAA2/NR1D1/PER2/RORA/PRKAB1/CRY1/PER1	3.92266167938485
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	33/2885	62/9376	1.72979258679488	IGF1R/KRAS/ADCY7/CAT/PIK3R1/PIK3CA/IRS2/INSR/PIK3R3/PRKAB2/PIK3CB/HSPA1B/AKT3/HSPA8/RPS6KB1/MTOR/HDAC2/EIF4EBP2/AKT2/HSPA1A/FOXO3/ADCY6/ADCY2/PRKACB/HRAS/PRKAA1/RPTOR/SIRT1/PRKACA/ADCY9/PRKAA2/IRS1/PRKAB1	3.84352683705626
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	20/2885	32/9376	2.03119584055459	ATG9A/MTOR/ULK2/WIPI2/ATG12/WIPI1/ATG2B/ATG2A/PIK3C3/ATG4D/GABARAPL1/ATG10/ATG4B/PIK3R4/ATG9B/BECN1/RPTOR/ATG7/ATG13/ATG4A	3.89540367127365
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	24/2885	41/9376	1.90238829944625	RAD50/ATM/TOPBP1/BRCA2/XRCC2/TOP3A/RBBP8/BRCA1/RPA1/NBN/BARD1/BRCC3/TOP3B/RAD51D/RPA4/UIMC1/POLD1/MUS81/BLM/PALB2/RAD52/XRCC3/RAD51B/BRIP1	3.86038807263898
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	94/2885	224/9376	1.36380292151523	NRP1/SLC2A1/FOS/JUN/CANX/DLG1/CREB3L2/CALR/EGR1/KRAS/EP300/TGFBR1/ADCY7/MAP3K1/ATM/NFATC3/PIK3R1/TLN1/XPO1/XIAP/TGFBR2/ATF6B/CREBBP/PIK3CA/SMAD2/SMAD4/PPP3CA/PIK3R3/PIK3CB/ANAPC5/NFKBIA/ATR/ANAPC4/TRRAP/AKT3/ELK4/NFKB1/CREB1/LTBR/CDKN1A/NFATC2/CCND1/AKT2/ETS2/PTEN/MAPK8/ANAPC1/E2F3/ADCY6/IKBKB/GPS2/ADCY2/HLA-E/ATF2/PRKACB/KAT2B/MAP2K4/CDC23/MAPK1/HRAS/CDC16/TP53/CRTC3/CDC27/JAK1/BCL2L1/RB1/STAT5B/CCND3/ZFP36/CHUK/MAP3K3/TBP/MYC/PPP3CB/CREB5/SMAD3/PRKACA/CCND2/ANAPC7/KAT2A/SRF/ADCY9/PPP3CC/CRTC1/CDKN2B/IKBKG/IL1R1/VAC14/CREB3L4/CRTC2/ESPL1/IL15RA/ANAPC2	3.67396426802997
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	44/2885	90/9376	1.58884652416715	EGFR/FOS/JUN/EML4/KRAS/MAPK14/NFATC3/PIK3R1/PIK3CA/PPP3CA/PIK3R3/PIK3CB/NFKBIA/PTPN11/IFNGR1/AKT3/RPS6KB1/NFKB1/MTOR/NFATC2/AKT2/PTEN/IKBKB/CSNK2A1/MAPK1/HRAS/JAK1/STAT3/RAF1/CD274/HIF1A/CHUK/MAP3K3/PPP3CB/MYD88/MAP2K6/PPP3CC/TRAF6/IKBKG/PTPN6/JAK2/LAT/TIRAP/PLCG1	3.74206884571541
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	36/2885	70/9376	1.67138400594206	MET/SLC2A1/JUN/EPAS1/GAB1/KRAS/EP300/RAPGEF1/PIK3R1/CREBBP/PIK3CA/PIK3R3/PIK3CB/PAK6/PTPN11/SOS1/AKT3/CDKN1A/AKT2/BRAF/CRK/SOS2/ARNT/MAPK1/VHL/HRAS/CUL2/PDGFB/CRKL/RAF1/TFE3/EGLN1/HIF1A/ARAF/PAK4/FLCN	3.75873085750348
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	33/2885	63/9376	1.70233556160766	GLI3/TCF7L2/GADD45B/DVL3/FZD5/FZD6/GSK3B/FZD3/PTCH2/APC/FZD10/POLK/BMP4/CDKN1A/CTNNB1/WNT4/GADD45A/GADD45G/TP53/WNT5A/AXIN2/PTCH1/DVL1/WNT2B/SUFU/FZD1/WNT3/FZD8/TCF7/DVL2/AXIN1/TCF7L1/WNT7A	3.7288324931083
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	102/2885	248/9376	1.33665790797786	AHNAK/FOS/JUN/DYNC1H1/HSP90B1/GCC2/KIF5B/TCF7L2/RHOB/BCL2/CYTH3/SNX18/NCKAP1/MAPK14/ROCK2/DYNLL2/DYNC1LI2/MYO6/PIK3C2A/TAB3/BIRC2/PIK3CA/CYFIP2/CYFIP1/ACBD3/RAB5B/PIK3CB/WASL/TAB2/NFKBIA/DCTN4/ACTR2/DCTN5/PFN2/DCTN1/CASP3/EXOC2/AKT3/NFKB1/EXOC4/AKT2/EXOC5/MAPK8/ABI1/KPNA4/DYNC1LI1/CTNNB1/IKBKB/VPS39/M6PR/MAP3K7/RAB7B/MAP2K4/MAPK1/NAIP/PIK3C3/KPNA3/HRAS/EXOC7/MAP2K7/FBXO22/FHOD1/KLC1/VPS41/RIPK1/KPNA1/RAF1/IRAK4/FYCO1/ARL8A/PLEKHM1/VPS11/SNX9/PIK3C2B/ACTR3C/TAB1/CHUK/TNFRSF10B/MYC/DNM2/VPS33A/MYD88/KLC4/MAP2K6/CYTH2/DYNC2H1/SNX33/ACTR1B/ELMO2/TCF7/VPS18/PLEKHM2/PYCARD/TRAF6/IKBKG/NOD1/KLC2/TCF7L1/TNFSF10/ACTR3B/TIRAP/VPS16	3.58203304047017
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	36/2885	71/9376	1.64784338614006	FOS/PRLR/KRAS/MAPK14/PIK3R1/GSK3B/PIK3CA/PIK3R3/PIK3CB/SOCS1/SOS1/AKT3/SOCS7/NFKB1/SHC1/SOCS5/CCND1/AKT2/FOXO3/MAPK8/SOCS6/SOS2/SOCS4/MAPK1/HRAS/ELF5/SOCS2/STAT3/RAF1/STAT5B/GALT/CCND2/ESR2/CISH/JAK2/SRC	3.65295024884018
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	13/2885	18/9376	2.3471596379742	HEXA/FUCA1/HEXB/MANBA/GLB1/MAN2B2/NEU1/FUCA2/GBA2/AGA/MAN2C1/ENGASE/NEU3	3.81387572112444
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	68/2885	155/9376	1.42576843517639	EGFR/PBX1/CDK6/CREB3L2/GNAQ/TCF7L2/ITPR2/DVL3/CAMK2G/FZD5/NCEH1/KMT2A/ADCY7/FZD6/USP8/GSK3B/ATF6B/LDLR/FZD3/APC/FZD10/CREB1/GNAI1/SP1/CDKN1A/GNAI2/CCND1/BRAF/GNA11/NR4A1/E2F3/ARNT/ADCY6/CTNNB1/WNT4/ADCY2/ATF2/PRKACB/KMT2D/CDKN1B/MAPK1/PLCB1/PDE8A/WNT5A/AXIN2/AHR/RB1/MEN1/DVL1/RBBP5/WNT2B/CREB5/ARMC5/PRKACA/FZD1/WNT3/ADCY9/FZD8/RASD1/CDKN2B/TCF7/WDR5B/DVL2/ITPR1/AXIN1/CREB3L4/TCF7L1/WNT7A	3.56330536587709
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	94/2885	227/9376	1.34577909435864	EGFR/ITGAV/CDK6/IL10RB/PDIA3/GNA12/CREB3L2/ROCK1/AKAP13/GNAQ/ITPR2/CALR/KRAS/MDM2/ADCY7/MAPK14/ROCK2/GNG12/NFATC3/PIK3R1/GSK3B/ARHGEF12/ATF6B/TAPBP/PIK3CA/PPP3CA/PIK3R3/PTK2/PIK3CB/NFKBIA/SOS1/CASP3/AKT3/RPS6KB1/NFKB1/CREB1/MTOR/GNAI1/SP1/CDKN1A/GNAI2/NFATC2/GNB4/CCND1/AKT2/GNA11/CRK/PXN/SOS2/E2F3/ADCY6/CTNNB1/IKBKB/ADCY2/HLA-E/ATF2/IRF3/GNB1/TSC2/PRKACB/TSC1/GNA13/MAPK1/TAPBPL/PLCB1/HRAS/TP53/JAK1/RAC3/BCAR1/TRAF5/RIPK1/STAT3/CRKL/RAF1/RB1/ARHGEF11/TBK1/CHUK/MYC/PPP3CB/CREB5/PRKACA/GNG10/MAP2K6/ADCY9/PPP3CC/PRKCA/ITPR1/IKBKG/IL1R1/SRC/CREB3L4/CXCR2	3.51582775016454
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	86/2885	205/9376	1.36337828126981	IL6ST/JUN/CDK6/DDB1/SCIN/ACTN4/DLG1/PMAIP1/CREB3L2/UBR4/CHD4/KRAS/EP300/RBPJ/MDM2/PIK3R1/SKP2/UBE3A/ATF6B/CREBBP/SND1/PIK3CA/REL/PIK3R3/RASA2/PIK3CB/DDX3X/NFKBIA/USP7/CASP3/NFKB1/CREB1/EIF2AK2/HDAC2/LTBR/CDKN1A/CCND1/PXN/RBL1/ACTN1/YWHAG/GTF2H3/HLA-E/ATF2/IRF3/PRKACB/KAT2B/CDKN1B/MAPK1/GTF2E2/HRAS/TP53/JAK1/SCRIB/GSN/GTF2A1/TRAF5/STAT3/HDAC11/RB1/STAT5B/HDAC7/CCND3/RBL2/HDAC6/DNAJA3/GTF2H2/TBP/CREB5/PRKACA/HDAC8/MAPKAPK2/CCND2/KAT2A/GTF2H2C/SRF/TRAF3/HDAC4/CDKN2B/IKBKG/VAC14/SRC/GTF2E1/CREB3L4/HDAC10/HDAC5	3.50695580276316
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	68/2885	156/9376	1.41662889392525	EGFR/CDK6/CLDN4/KRAS/CFLAR/TLR3/PIK3R1/GSK3B/OCLN/LDLR/PIAS1/PIK3CA/MAVS/PIK3R3/PIK3CB/NFKBIA/SOS1/CASP3/AKT3/RXRA/PPP2R2A/NFKB1/EIF2AK2/CDKN1A/IFNAR1/CCND1/AKT2/BRAF/SOS2/E2F3/YWHAG/CTNNB1/IKBKB/PPARA/PPP2R2B/IRF3/MAPK1/PPP2R2D/HRAS/PPP2R1A/TP53/JAK1/IFNAR2/RIPK1/STAT3/RAF1/RB1/STAT2/TBK1/RNASEL/CD81/CHUK/CLDN19/MYC/CLDN12/TYK2/ARAF/CLDN3/TRAF3/APAF1/CLDN1/CLDN23/PPP2R1B/TRAF6/IKBKG/IKBKE/NR1H3/RSAD2	3.49823488838594
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	15/2885	23/9376	2.1195087031874	B4GALT1/B4GAT1/B3GALNT2/FUT4/FKRP/POMT1/POMGNT1/POMT2/CHST10/POMGNT2/FKTN/B3GAT2/B4GALT3/POMK/ST3GAL3	3.58359289938956
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	84/2885	203/9376	1.3447917289189	ITGA6/ITGB4/EGFR/LAMB1/ITGAV/MET/LAMC1/LAMA5/ITGB1/COL4A2/JUN/ITGB5/IGF1R/ACTN4/ITGB8/ROCK1/COL4A1/ARHGAP5/VCL/PPP1R12A/DIAPH1/BCL2/ROCK2/VAV3/PPP1R12B/RAPGEF1/PIK3R1/TLN1/GSK3B/XIAP/PDGFD/PIP5K1A/DOCK1/PDPK1/BIRC2/PIK3CA/PIK3R3/PTK2/PIK3CB/PAK6/ITGB6/SOS1/LAMB4/AKT3/ERBB2/LAMB2/SHC1/PIP5K1B/CCND1/AKT2/BRAF/PTEN/MAPK8/CRK/PXN/FN1/SOS2/ACTN1/MYLK3/CTNNB1/ITGA3/ARHGAP35/MAPK1/HRAS/RAC3/BCAR1/PDGFB/CRKL/RAF1/PIP5K1C/CCND3/PDGFA/PDGFC/LAMA1/PAK4/THBS1/CCND2/CAPN2/PRKCA/VWF/PGF/SRC/COL2A1/MYLK4	3.31094452148152
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	24/2885	44/9376	1.77268000630219	GTF2I/TAF3/TAF2/TAF4B/TAF5L/CDK7/TAF11/GTF2H3/TAF1/GTF2E2/TAF8/GTF2A1/TAF6/ERCC3/GTF2H2/TBP/GTF2H2C/CCNH/TAF4/TAF6L/TAF5/TAF7L/GTF2E1/ERCC2	3.42484869903562
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	15/2885	24/9376	2.03119584055459	EXTL2/HS6ST2/XYLT1/GLCE/B3GAT3/EXT2/EXT1/B4GALT7/NDST1/XYLT2/EXTL3/HS2ST1/HS6ST1/B3GALT6/HS3ST3B1	3.37207532076555
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	33/2885	68/9376	1.57716382913651	DUSP6/TCF7L2/KRAS/PIK3R1/PIK3CA/PIK3R3/PIK3CB/SOS1/AKT3/RPS6KB1/NFKB1/MTOR/JUP/CCND1/AKT2/BRAF/SOS2/CEBPA/IKBKB/MAPK1/HRAS/PPARD/STAT3/RAF1/STAT5B/CHUK/MYC/ARAF/TCF7/PER2/IKBKG/TCF7L1/PML	3.18440368240617
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	13/2885	20/9376	2.11244367417678	DHCR24/LBR/LIPA/SQLE/MSMO1/SOAT1/TM7SF2/FDFT1/SC5D/DHCR7/HSD17B7/NSDHL/CYP2R1	3.32009617579475
Human Diseases	Cancer: specific types	hsa05214	Glioma	36/2885	76/9376	1.5394326370519	EGFR/CDK6/IGF1R/GADD45B/KRAS/CAMK2G/MDM2/PIK3R1/PIK3CA/PIK3R3/PIK3CB/SOS1/AKT3/PLCG2/POLK/SHC1/MTOR/CDKN1A/CCND1/AKT2/BRAF/PTEN/SOS2/E2F3/GADD45A/MAPK1/GADD45G/HRAS/TP53/PDGFB/RAF1/RB1/PDGFA/ARAF/PRKCA/PLCG1	3.14778660588136
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	53/2885	122/9376	1.41184760064778	FOS/JUN/DLG1/KRAS/MAPK14/VAV3/NFATC3/PIK3R1/GSK3B/PDPK1/PIK3CA/PPP3CA/PIK3R3/PIK3CB/PAK6/NFKBIA/PTPN11/SOS1/AKT3/PPP2R2A/NFKB1/NFATC2/NCK2/AKT2/PPP2R5E/MAPK8/NCK1/SOS2/IKBKB/PPP2R5C/PPP2R3A/PPP2R2B/MAP3K7/MAPK1/PPP2R3B/PPP2R2D/HRAS/PPP2R1A/MALT1/MAP2K7/RAF1/CHUK/PPP3CB/TEC1/PPP2R5A/PAK4/PPP3CC/PPP2R5D/PPP2R1B/IKBKG/PTPN6/LAT/PLCG1	3.05249140905848
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	18/2885	32/9376	1.82807625649913	ACSS1/HADHA/DBT/ACACA/ACOX1/ACADS/BCKDHB/PCCB/PCCA/ACSS2/SUCLG2/ABAT/HIBCH/MCEE/EHHADH/MLYCD/ALDH6A1/ACSS3	3.12810735148664
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	38/2885	83/9376	1.48791213380385	SLC27A2/IDH1/ACSL3/CAT/FAR1/ABCD3/ABCD4/ACOX1/PEX26/PEX1/EPHX2/SLC25A17/ACSL4/PEX11B/GNPAT/CRAT/GSTK1/PEX11A/NUDT12/NUDT19/ACSL1/ABCD1/HACL1/EHHADH/PEX16/PEX13/PEX6/PEX14/MLYCD/MVK/AGPS/MPV17L2/DECR2/PXMP4/PEX12/ACSL5/NUDT13/PEX5	2.97649692783911
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	33/2885	70/9376	1.53210200544689	SLC2A1/ACSL3/CPT1A/IRS2/PRKAB2/APPL1/NFKBIA/PTPN11/G6PC3/AKT3/RXRA/NFKB1/MTOR/AKT2/MAPK8/ADIPOR1/IKBKB/ACSL4/PPARA/ADIPOR2/CAMKK2/PRKAA1/STAT3/ACSL1/RXRB/CHUK/STK11/PRKAA2/IRS1/ACSL5/IKBKG/PRKAB1/JAK2	2.97896317087021
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	36/2885	78/9376	1.49996000533262	DHX36/BTG2/CNOT1/CNOT6L/BTG3/DCP2/XRN1/BTG1/DDX6/PABPC1/XRN2/DCP1A/DIS3L/CNOT2/TOB2/PABPC4/PNPT1/TOB1/PARN/CNOT6/DIS3/CNOT4/LSM8/EXOSC10/PAN3/PAN2/CNOT7/ZCCHC7/CNOT3/PABPC1L/EDC3/EXOSC6/CNOT8/PATL1/DCP1B/ENO3	2.95590544029398
Human Diseases	Cancer: specific types	hsa05218	Melanoma	34/2885	73/9376	1.5136582702215	CDH1/EGFR/MET/CDK6/IGF1R/GADD45B/KRAS/MDM2/PIK3R1/PDGFD/PIK3CA/PIK3R3/PIK3CB/AKT3/POLK/CDKN1A/CCND1/AKT2/BRAF/PTEN/E2F3/GADD45A/MAPK1/GADD45G/HRAS/TP53/PDGFB/RAF1/RB1/PDGFA/PDGFC/FGFR1/ARAF/FGF2	2.93715554847998
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	98/2885	253/9376	1.2588597146204	EGFR/ITGB1/JUN/ACTN4/ROCK1/RPS6KA5/ITPR2/WASF2/VCL/DIAPH1/BCL2/CYTH3/MDM2/MAPK14/ROCK2/ATM/FBXW11/PIK3R1/TLN1/GSK3B/FOXO4/TAB3/DOCK1/PIK3CA/PIK3R3/PTK2/PIK3CB/FNBP1L/WASL/CAST/TAB2/NFKBIA/ACTR2/PFN2/AKT3/RPS6KB1/NFKB1/ATG14/PLCG2/U2AF1/MTOR/CUL1/AKT2/RRAGC/FOXO3/MAPK8/WIPI2/CRK/PXN/ATG12/ACTN1/HCLS1/WIPI1/IKBKB/CAPN1/IRF3/MAP3K7/MAPK1/NAIP/PIK3C3/PLCB1/MALT1/TP53/BCL2L1/PLCE1/BCAR1/RRAGB/TRAF5/RIPK1/BTRC/CRKL/TECPR1/PIK3R4/BECN1/CTTN/ACTR3C/RPTOR/TAB1/TBK1/CHUK/FOXO6/MYD88/FNBP1/WASF1/CYTH2/CAPN2/ELMO2/PYCARD/ITPR1/TRAF6/IKBKG/NOD1/IL1R1/PRKCE/SRC/ACTR3B/PLCG1/TNIP1	2.78265031465711
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	50/2885	117/9376	1.38885185678946	BPTF/SMARCA2/BAZ1B/ARID1A/RSF1/PBRM1/BAZ2B/CHD4/BAZ2A/BRD7/SMARCC1/SMARCA5/EPC1/BRD8/BRD9/BAZ1A/YY1/ARID2/INO80D/SMARCA4/ARID1B/SMARCD1/ING3/TRRAP/HDAC2/EP400/RBBP4/SS18/SMARCD2/EPC2/INO80/MTA3/ACTR6/PHF6/PHF10/NFRKB/DPF2/SMARCE1/DMAP1/SMARCC2/GATAD2A/CECR2/GATAD2B/CHD3/SS18L1/INO80E/BCL7A/YY2/SRCAP/MTA1	2.82161534343759
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	59/2885	142/9376	1.350316108087	ITGAV/FOS/JUN/HSP90B1/DUSP1/CTSL/GPC1/BCL2/BMPR2/MAPK14/NFE2L2/PIK3R1/BMPR1A/PIK3CA/MGST3/PIK3R3/PTK2/PIK3CB/ACVR2B/ACVR2A/AKT3/NFKB1/BMP4/MGST2/EDN1/AKT2/TRPV4/MAPK8/CTNNB1/IKBKB/MEF2A/MAP3K7/ASS1/MAP2K4/PRKCZ/MAP2K7/TP53/RAC3/PRKAA1/ACVR1/PDGFB/SUMO4/THBD/PDGFA/CHUK/GSTM3/GSTM2/MAP2K6/KEAP1/PRKAA2/PIAS4/CDH5/IKBKG/MAPK7/IL1R1/SRC/GSTO2/MAP2K5/MAP3K5	2.80422002820392
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	78/2885	196/9376	1.29333286174088	IL6ST/FOS/JUN/CDK6/TCF7L2/ITPR2/KRAS/EP300/MAPK14/GNG12/NFATC3/TLR3/PIK3R1/GSK3B/CREBBP/PIK3CA/PPP3CA/PIK3R3/PIK3CB/NFKBIA/IFNGR1/CASP3/AKT3/NFKB1/RCAN1/ATG14/PLCG2/CREB1/MTOR/EIF2AK2/CDKN1A/NFATC2/IFNAR1/GNB4/CCND1/AKT2/MAPK8/E2F3/CTNNB1/IKBKB/HLA-E/IRF3/GNB1/MAP2K4/MAPK1/PIK3C3/HRAS/MAP2K7/TP53/JAK1/IFNAR2/PDGFB/STAT3/RAF1/RB1/BECN1/STAT2/HIF1A/ZFP36/TBK1/CHUK/MYC/PPP3CB/TYK2/MAPKAPK2/GNG10/MAP2K6/TRAF3/PPP3CC/TCF7/ITPR1/IKBKG/IKBKE/JAK2/SRC/TCF7L1/FGF2/PLCG1	2.76675151656146
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	25/2885	51/9376	1.59309477690556	PDIA4/ATP6AP1/ATP6V1B1/TJP1/SEC61A1/TJP2/ATP6V0A1/ATP6V1H/ATP6V0B/PLCG2/ATP6V1C2/ATP6V1A/KDELR1/SLC12A2/PRKACB/TCIRG1/SEC61A2/ATP6V1E2/ATP6V0A2/ATP6V0A4/ATP6V1B2/PRKACA/ADCY9/PRKCA/PLCG1	2.8313105656805
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	21/2885	41/9376	1.66458976201547	CDH1/EGFR/RPS6KA5/KRAS/MDM2/ERBB2/CDKN1A/CCND1/BRAF/E2F3/MAPK1/HRAS/DAPK1/TP53/RAF1/RB1/HBEGF/MYC/ARAF/THBS1/SRC	2.84309359070464
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	50/2885	119/9376	1.3655098087762	FOS/JUN/CREB3L2/RPS6KA5/JAG1/MMP14/CFLAR/MAPK14/PIK3R1/XIAP/ADAM17/ATF6B/TAB3/BIRC2/PIK3CA/PIK3R3/PIK3CB/DNM1L/TAB2/NFKBIA/CASP3/AKT3/NFKB1/CREB1/EDN1/AKT2/ITCH/BAG4/MAPK8/IKBKB/ATF2/JUNB/CYLD/MAP3K7/MAP2K4/MAPK1/RHBDF1/MAP2K7/TRAF5/RIPK1/TAB1/CHUK/RPS6KA4/CREB5/MAP2K6/TRAF3/FRMD8/IKBKG/CREB3L4/MAP3K5	2.67510065276088
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	83/2885	214/9376	1.26048040946565	FOS/JUN/DDB1/PDIA3/GNAQ/ITPR2/CALR/KRAS/BCL2/LIMK2/MAPK14/GNG12/CUL5/ATM/NFATC3/FBXW11/PIK3R1/TAPBP/PIK3CA/PPP3CA/PIK3R3/PTK2/PIK3CB/PAK6/TAB2/NFKBIA/AP1S3/ATR/AP1B1/CASP3/AKT3/WEE1/RPS6KB1/NFKB1/PLCG2/MTOR/GNAI1/GNAI2/CUL1/NFATC2/GNB4/AKT2/MAPK8/GNA11/CRK/PXN/IKBKB/HLA-E/AP1G1/IRF3/MAP3K7/GNB1/MAPK1/TAPBPL/HRAS/MAP2K7/BCL2L1/RAC3/AP1M1/TRAF5/RIPK1/BTRC/CRKL/RAF1/IRAK4/TAB1/CUL4B/TBK1/CHUK/AP1G2/CUL4A/PPP3CB/PAK4/GNG10/MYD88/MAP2K6/TRIM5/PPP3CC/PRKCA/ITPR1/TRAF6/IKBKG/PLCG1	2.56974216881951
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	78/2885	200/9376	1.26746620450607	ITGB1/MYH10/FOS/JUN/CLDN4/GNA12/ROCK1/WASF2/TJP1/CYTH3/MYO1C/NCKAP1/MAPK14/ROCK2/MYO6/SEC24D/WIPF2/ARHGEF12/OCLN/TAB3/CYFIP2/CYFIP1/TMED10/BAIAP2/WASL/TAB2/NFKBIA/ACTR2/PTPN11/MYO5B/CASP3/NFKB1/TMBIM6/SEC24A/SEC24B/NCK2/MAPK8/ABI1/MYH9/NCK1/HCLS1/MYO1D/IKBKB/MAP3K7/GNA13/MAPK1/NAIP/RIPK1/ABL1/IRAK4/ARHGEF11/CTTN/ACTR3C/TAB1/CHUK/TNFRSF10B/CLDN19/CLDN12/MYO5C/SEC24C/CLDN3/LPAR1/MYD88/WASF1/CYTH2/CLDN1/MYO1B/CLDN23/PYCARD/TRAF6/IKBKG/PTPN6/MYO5A/IL1R1/SRC/TNFSF10/ACTR3B/TIRAP	2.54894199542888
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	16/2885	30/9376	1.73328711727325	SLC19A1/MTR/FOLR1/GGH/NFKB1/SLC46A1/IKBKB/GART/ABCG2/CHUK/ABCC1/MTHFR/ABCC5/FPGS/ABCC2/IKBKG	2.6817885769542
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	10/2885	16/9376	2.03119584055459	HEXA/HEXB/NAGA/GLA/B3GALNT1/A4GALT/GBGT1/ST3GAL2/FUT1/ST3GAL1	2.75211109972345
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	58/2885	144/9376	1.30899287502407	TRA2B/TCF7L2/MAPK14/FASN/GSK3B/TRA2A/TAB3/LPIN2/CPT1A/PRKAB2/TAB2/NFKBIA/CASP3/ACACA/AKT3/ACOX1/NFKB1/CCND1/AKT2/FOXO3/MAPK8/ACADVL/CTNNB1/ADIPOR1/LPIN1/IKBKB/PPARA/IRF3/MAP3K7/MAP2K4/ADIPOR2/MAP2K7/CAMKK2/PRKAA1/RIPK1/ACADM/IRAK4/TAB1/TBK1/CHUK/SIRT1/MLYCD/SREBF1/IL17RA/IL17RC/MYD88/MAP2K6/SCD5/TRAF3/PRKAA2/TCF7/TRAF6/IKBKG/PRKAB1/IKBKE/TCF7L1/TIRAP/MAP3K5	2.49106210883474
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	83/2885	216/9376	1.24880929456319	HSPA5/FOS/JUN/OLR1/HSP90B1/ABCA1/ATF6/MIB1/KRAS/CAMK2G/BCL2/MAPK14/ROCK2/NFE2L2/VAV3/NFATC3/PIK3R1/GSK3B/VLDLR/XBP1/LDLR/PDPK1/PIK3CA/DDIT3/PPP3CA/PIK3R3/PTK2/PIK3CB/TAB2/NFKBIA/HSPA1B/POU2F1/CASP3/AKT3/RXRA/HSPA8/NFKB1/NFATC2/AKT2/HSPA1A/MAPK8/IKBKB/PPARG/IRF3/MAP3K7/MAP2K4/MAPK1/PLCB1/HRAS/MAP2K7/TP53/BCL2L1/EIF2AK3/ERN1/STAT3/IRAK4/TAB1/RXRB/TBK1/CHUK/TNFRSF10B/PPP3CB/MIB2/ABCG1/MYD88/MAP2K6/TRAF3/PPP3CC/APAF1/PRKCA/PYCARD/SELP/ITPR1/TRAF6/IKBKG/IKBKE/JAK2/SRC/TNFSF10/TIRAP/AGER/PLCG1/MAP3K5	2.46631464071998
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	15/2885	28/9376	1.74102500618965	HACD3/HADHA/THEM4/PPT1/HSD17B12/ELOVL4/HACD2/ELOVL1/PPT2/TECR/HACD4/ELOVL5/MBLAC2/ELOVL7/ELOVL6	2.61791336247642
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	9/2885	14/9376	2.08923000742758	B4GALT1/B3GNT2/FUT8/B4GALT4/ST3GAL2/B4GALT3/ST3GAL1/ST3GAL3/CHST6	2.71895512058132
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	34/2885	78/9376	1.41662889392525	CDH1/MET/ITGB1/CLTC/GAB1/WASF2/VCL/PIK3R1/DOCK1/PIK3CA/PIK3R3/PTK2/CD2AP/PIK3CB/WASL/ARHGAP10/CBL/ACTR2/ELMO3/SHC1/CRK/PXN/FN1/HCLS1/CTNNB1/BCAR1/CRKL/CTTN/ACTR3C/DNM2/WASF1/ELMO2/SRC/ACTR3B	2.46322826026453
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	56/2885	140/9376	1.29996533795494	CDH1/GNAQ/SLC9A1/ITPR2/JAG1/EGR1/KRAS/TGFBR1/ADCY7/NOTCH3/GNG12/SMAD2/SMAD4/PRKAB2/PDE3B/TFAM/AKT3/RPS6KB1/APELA/MTOR/GNAI1/GNAI2/GNB4/CCND1/AKT2/MRAS/MYLK3/ADCY6/MEF2A/ADCY2/GNB1/PRKACB/GNA13/MAPK1/PIK3C3/PLCB1/HRAS/PRKAA1/RAF1/PIK3R4/BECN1/SPHK2/SMAD3/PRKACA/GNG10/ADCY9/HDAC4/PRKAA2/ITPR1/SLC8A1/MEF2D/PRKAB1/PRKCE/HDAC5/NRF1/MYLK4	2.38394302328735
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	16/2885	31/9376	1.67737462961928	HSPA5/SEC62/SEC63/SEC61A1/SRPRA/TMEM208/SPCS3/SRPRB/SPCS2/SEC11C/IMMP2L/BAG6/SEC61A2/OXA1L/IMMP1L/GET4	2.51838928560624
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	42/2885	101/9376	1.35144911371553	CREB3L2/GNAQ/TCF7L2/DVL3/KRAS/CAMK2G/EP300/FZD5/ADCY7/FZD6/GSK3B/CREBBP/FZD3/FZD10/CREB1/GNAI1/EDN1/EDNRB/GNAI2/ADCY6/CTNNB1/WNT4/ADCY2/PRKACB/MAPK1/PLCB1/HRAS/WNT5A/RAF1/DVL1/WNT2B/PRKACA/FZD1/WNT3/ADCY9/PRKCA/FZD8/TCF7/DVL2/CREB3L4/TCF7L1/WNT7A	2.36738516914131
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	131/2885	362/9376	1.17607361375758	CSF3R/ITGA6/ITGB4/EGFR/LAMB1/ITGAV/MET/LAMC1/LAMA5/ITGB1/COL4A2/CDK6/ITGB5/IGF1R/HSP90B1/PRLR/PKN2/ITGB8/CREB3L2/COL4A1/ERBB3/KRAS/FGFR2/BCL2/PHLPP1/MDM2/EFNA5/GNG12/PIK3R1/MCL1/GSK3B/EFNA1/ATF6B/PDGFD/GHR/PDPK1/PIK3CA/THEM4/INSR/PIK3R3/PTK2/MAGI1/PIK3CB/ITGB6/G6PC3/SOS1/LAMB4/AKT3/ERBB2/RXRA/LAMB2/RPS6KB1/PPP2R2A/NFKB1/CREB1/MTOR/CDKN1A/IFNAR1/GNB4/PHLPP2/IL4R/CCND1/AKT2/PTEN/PPP2R5E/FOXO3/EPHA2/NR4A1/FN1/SOS2/YWHAG/ITGA3/IKBKB/PPP2R5C/ATF2/PPP2R3A/PPP2R2B/SGK3/GNB1/TSC2/TSC1/ANGPT1/CDKN1B/BRCA1/MAPK1/PPP2R3B/PPP2R2D/HRAS/PPP2R1A/TP53/JAK1/BCL2L1/IFNAR2/PRKAA1/PDGFB/ERBB4/BCL2L11/RAF1/CCND3/RBL2/RPTOR/PDGFA/CHUK/BDNF/PDGFC/FGFR1/MYC/CREB5/PPP2R5A/LAMA1/THBS1/CCND2/LPAR1/GNG10/EFNA4/STK11/PRKCA/PRKAA2/IRS1/MAGI2/VWF/PPP2R5D/PPP2R1B/IKBKG/PGF/JAK2/CREB3L4/NTF4/CRTC2/COL2A1/FGF2	2.2776790574955
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	15/2885	29/9376	1.68098966114863	FRMD6/RASSF6/TEAD1/LATS2/YAP1/WWC1/SAV1/TEAD3/LATS1/WWTR1/MOB1B/LIMD1/AJUBA/NF2/WTIP	2.44853399717027
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	52/2885	130/9376	1.29996533795494	EGFR/COL4A2/FOS/JUN/CREB3L2/COL4A1/KRAS/TGFBR1/ADCY7/MAPK14/GNG12/PIK3R1/TGFBR2/ATF6B/PIK3CA/SMAD2/PIK3R3/PIK3CB/NFKBIA/SOS1/AKT3/NFKB1/CREB1/SHC1/GNAI1/EDN1/EDNRB/GNAI2/GNB4/AKT2/MAPK8/SOS2/ADCY6/ADCY2/ATF2/GNB1/PRKACB/MAP2K4/MAPK1/PRKCZ/PLCB1/HRAS/MAP2K7/RAF1/ARRB1/CREB5/PRKACA/GNG10/ADCY9/PRKCA/SRC/CREB3L4	2.29598236154975
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	43/2885	105/9376	1.33091689362053	GADD45B/ERC1/BCL2/CFLAR/ATM/PARP1/PPP1R13L/XIAP/TAB3/BIRC2/TAB2/NFKBIA/NFKB1/PLCG2/LTBR/IKBKB/EDARADD/CYLD/MAP3K7/CSNK2A1/GADD45A/GADD45G/MALT1/BCL2L1/TRAF5/RIPK1/PIDD1/IRAK4/BLNK/PLAU/TAB1/CHUK/MYD88/TRAF3/EDA2R/PIAS4/TRAF6/IKBKG/IL1R1/TRIM25/LAT/TIRAP/PLCG1	2.27328057137129
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	80/2885	212/9376	1.22638239429711	CDH1/EGFR/MET/ITGB1/CTNND1/IGF1R/GNAQ/KRAS/FGFR2/PRKCI/PARD3/ADCY7/MAPK14/EFNA5/VAV3/RAPGEF1/PIK3R1/TLN1/RAPGEF2/EFNA1/PDGFD/KRIT1/PIK3CA/MAGI3/INSR/PIK3R3/MAGI1/PIK3CB/EVL/PFN2/AKT3/PARD6B/GNAI1/GNAI2/AKT2/ID1/BRAF/ENAH/EPHA2/CRK/TIAM1/MRAS/ADCY6/CTNNB1/ADCY2/ANGPT1/MAPK1/PRKCZ/PLCB1/RAPGEF6/HRAS/PLCE1/RAC3/BCAR1/PDGFB/CRKL/RAF1/PRKD2/FARP2/PDGFA/RALGDS/SIPA1L1/PDGFC/FGFR1/THBS1/LPAR1/MAP2K6/ADCY9/EFNA4/PRKCA/SIPA1L3/MAGI2/ADORA2B/PARD6G/PGF/SRC/LAT/RAPGEF3/FGF2/PLCG1	2.22264847270383
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	58/2885	149/9376	1.26506693962058	EGFR/PLPP3/GNA12/GAB1/KRAS/CYTH3/ADCY7/PIK3R1/PDGFD/PIP5K1A/AGPAT1/PIK3CA/DGKH/INSR/PIK3R3/PIK3CB/PTPN11/SOS1/DGKA/AKT3/DGKD/PLCG2/AGPAT3/SHC1/MTOR/PIP5K1B/AKT2/SOS2/MRAS/ADCY6/ADCY2/TSC2/TSC1/GNA13/MAPK1/PLCB1/HRAS/PDGFB/RAF1/PIP5K1C/PLD2/AGPAT4/PDGFA/RALGDS/PDGFC/DGKZ/SPHK2/PLD1/DNM2/LPAR1/CYTH2/ADCY9/PRKCA/AGPAT5/GAB2/RAPGEF3/CXCR2/PLCG1	2.17430858273034
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	41/2885	101/9376	1.31927175386516	COL4A2/JUN/COL4A1/EGR1/KRAS/DIAPH1/BCL2/TGFBR1/MAPK14/PIK3R1/TGFBR2/PIK3CA/SMAD2/SMAD4/PIK3R3/PIK3CB/CASP3/AKT3/NFKB1/PLCG2/EDN1/CCND1/AKT2/MAPK8/FN1/CDKN1B/MAPK1/PRKCZ/PLCB1/HRAS/PLCE1/STAT3/STAT5B/F3/THBD/SMAD3/PRKCA/JAK2/PRKCE/AGER/PLCG1	2.15063628141031
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	14/2885	28/9376	1.62495667244367	B4GALT1/B3GNT2/GCNT2/B3GNT5/B3GNT3/ST3GAL6/B4GALT4/B3GALNT1/FUT4/A4GALT/ST3GAL4/FUT1/B4GALT3/ST3GAL3	2.20786398582124
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	12/2885	23/9376	1.69560696254992	PCYOX1/HMGCR/ZMPSTE24/ICMT/NUS1/HMGCS1/IDI1/RCE1/PDSS2/DHDDS/MVK/FNTB	2.22666618371305
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	17/2885	36/9376	1.53468130175236	GALNT11/C1GALT1/B4GALT5/GCNT4/GALNT1/B3GNT3/GALNT18/GALNT6/C1GALT1C1/GALNT7/GALNT12/GALNT3/ST3GAL2/ST6GALNAC2/GALNT2/ST3GAL1/GALNT10	2.14276997041552
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	44/2885	112/9376	1.27675167120574	ITGA6/LAMB1/LAMC1/LAMA5/ITGB1/IL10RB/BCL2/MAPK14/XIAP/LDLR/PDPK1/BIRC2/TAB2/NFKBIA/SOCS1/HSPA1B/LAMB4/IFNGR1/CASP3/AKT3/LAMB2/HSPA8/NFKB1/GNAI1/GNAI2/AKT2/HSPA1A/MAPK8/IKBKB/MAP3K7/MAPK1/JAK1/BCL2L1/STAT3/IRAK4/TAB1/CHUK/LAMA1/TYK2/MYD88/MAP2K6/TRAF6/IKBKG/JAK2	1.96427700530988
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	55/2885	144/9376	1.24128634700558	PUM1/PSMD1/GNAQ/ITPR2/ATP2A2/PUM2/RB1CC1/AFG3L2/RBPJ/ATXN2/PIK3R1/VLDLR/XBP1/PIK3CA/PIK3R3/PIK3CB/AKT3/ATG14/MTOR/SP1/ULK2/ATXN1/AKT2/MAPK8/WIPI2/OPA1/OMA1/WIPI1/ATG2B/ATG2A/NOP56/PIK3C3/PLCB1/PSMA6/ERN1/NRBF2/ATXN2L/PIK3R4/BECN1/ULK1/ATXN1L/ATXN3/TBP/MCU/CIC/ATG13/PRKCA/KCNC3/BEAN1/ITPR1/RORA/PSMA8/AMBRA1/NFYA/MAP3K5	1.94522050502925
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	19/2885	42/9376	1.47019889411571	TFRC/SLC40A1/SLC3A2/ACSL3/SLC11A2/LPCAT3/PCBP2/STEAP3/GCLM/NCOA4/ACSL4/PRNP/GCLC/TP53/SLC39A8/ACSL1/ATG7/SLC7A11/ACSL5	2.03598743129932
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	20/2885	45/9376	1.44440593106104	ABCA1/ABCB1/ABCA5/ABCD3/ABCD4/ABCB8/ABCB10/ABCC10/ABCB7/ABCG2/ABCD1/ABCC1/ABCB9/DEFB1/ABCG1/ABCC5/ABCB4/ABCC2/ABCC9/ABCA12	1.9921624550122
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	21/2885	48/9376	1.42183708838821	HADHA/MCCC2/DBT/BCAT1/ACADS/HMGCS1/IVD/BCKDHB/PCCB/ACADSB/MCCC1/ACADM/PCCA/ABAT/HIBCH/MCEE/EHHADH/ALDH6A1/ACAD8/OXCT1/ACSF3	1.95332205219591
NA	NA	hsa03272	Virion - Hepatitis viruses	21/2885	48/9376	1.42183708838821	EGFR/DPP4/CLDN4/TGOLN2/LAMP2/LAMP1/OCLN/LDLR/IST1/PDCD6IP/CHMP1B/VPS4B/HSPG2/CD81/CLDN19/CLDN12/CLDN3/CHMP1A/CLDN1/CLDN23/CHMP7	1.95332205219591
NA	NA	hsa04518	Integrin signaling	58/2885	154/9376	1.22399333768485	FBN1/CDH1/ITGA6/ITGB4/EGFR/LAMB1/ITGAV/MET/LAMC1/LAMA5/ITGB1/COL4A2/ITGB5/IGF1R/ACTN4/ITGB8/COL4A1/FERMT1/FRAS1/VCL/PIK3R1/TLN1/GSK3B/FREM2/PDGFD/PIK3CA/PIK3R3/PTK2/PIK3CB/ITGB6/LAMB4/FERMT2/AKT3/ERBB2/LAMB2/MTOR/NCK2/CCND1/AKT2/PXN/FN1/ACTN1/CTNNB1/ITGA3/LIMS1/RAC3/PDGFB/CCND3/PDGFA/PDGFC/NPNT/LAMA1/THBS1/CCND2/VWF/PGF/SRC/COL2A1	1.86846791664682
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	37/2885	93/9376	1.29297627699819	EGFR/JUN/MAP3K4/GNAQ/ITPR2/EGR1/KRAS/CAMK2G/MMP14/ADCY7/MAPK14/MAP3K2/MAP3K1/SOS1/MAPK8/GNA11/SOS2/ADCY6/ADCY2/PRKACB/MAP2K4/MAPK1/PLCB1/HRAS/MAP2K7/RAF1/PLD2/HBEGF/MAP3K3/PLD1/PRKACA/MAP2K6/ADCY9/PRKCA/ITPR1/MAPK7/SRC	1.89292103496971
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	13/2885	27/9376	1.5647730919828	HACD3/HSD17B12/ELOVL4/ACOX1/HACD2/ELOVL1/TECR/FADS1/HACD4/SCD5/ELOVL5/ELOVL7/ELOVL6	1.95918768208367
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	9/2885	17/9376	1.72054235905801	NRP2/DAG1/MYH10/TFRC/PCDH11X/LAMP2/LAMP1/MYH9/PCDH11Y	1.9823119385095
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	26/2885	63/9376	1.3412340788424	DDB1/POLR2J3/POLR2A/POLR2B/XPC/ERCC5/CDK7/ERCC4/RFC1/GTF2H3/RPA1/XPA/POLR2J2/POLE/ERCC3/GTF2H2/CUL4B/UVSSA/RPA4/CUL4A/ERCC6/GTF2H2C/CCNH/POLD1/POLR2M/ERCC2	1.81167634176298
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	66/2885	180/9376	1.19163489312536	PDIA3/CALR/BCL2/SRSF6/SRSF5/TLR3/PIK3R1/TAPBP/BIRC2/PIK3CA/MAVS/PIK3R3/PIK3CB/TAB2/NFKBIA/PTPN11/SRSF8/POU2F1/IFNGR1/CASP3/AKT3/CD74/NFKB1/HCFC1/MTOR/EIF2AK2/IFNAR1/SRSF7/NXF1/SRSF2/AKT2/SRSF4/IKBKB/HLA-E/IRF3/MAP3K7/TSC2/ZC3HAV1/TSC1/TAPBPL/TP53/JAK1/BCL2L1/IFNAR2/TRAF5/IFIH1/IRAK4/STAT2/TAB1/TBK1/RNASEL/CHUK/DAXX/EIF2B5/PILRB/TYK2/HCFC2/MYD88/TRAF3/APAF1/TRAF6/IKBKG/IKBKE/JAK2/SRC/PML	1.73066935015456
Human Diseases	Infectious disease: viral	hsa05162	Measles	51/2885	136/9376	1.21871750433276	CD46/FOS/JUN/CDK6/ADAR/BCL2/PIK3R1/GSK3B/PIK3CA/MAVS/PIK3R3/PIK3CB/TAB2/NFKBIA/HSPA1B/CASP3/AKT3/HSPA8/NFKB1/EIF2AK2/IFNAR1/CCND1/AKT2/HSPA1A/MAPK8/IKBKB/IRF3/MAP3K7/CSNK2A1/CDKN1B/TP53/JAK1/BCL2L1/IFNAR2/STAT3/STAT5B/IFIH1/IRAK4/CCND3/STAT2/TBK1/CHUK/TYK2/CCND2/MYD88/TRAF3/APAF1/TRAF6/IKBKG/IKBKE/BBC3	1.71285165922013
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	19/2885	44/9376	1.4033716716559	DYNC1H1/CREB3L2/DYNLL2/DYNC1LI2/VAMP2/RAB5B/DCTN4/DCTN5/DCTN1/CREB1/ADCY6/DYNC1LI1/PRKACB/NSF/CREB5/PRKACA/ADCY9/DYNC2H1/CREB3L4	1.78791599838322
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	53/2885	142/9376	1.21299582590866	FOS/JUN/FOSB/ITPR2/JUND/ATP2A2/TGFBR1/MAPK14/PIK3R1/TGFBR2/TMEM64/PIK3CA/PPP3CA/PIK3R3/PIK3CB/TAB2/NFKBIA/SIRPA/SOCS1/IFNGR1/AKT3/NFKB1/PLCG2/CREB1/NFATC2/IFNAR1/AKT2/MAPK8/IKBKB/FOSL2/PPARG/JUNB/CYLD/MAP3K7/MAPK1/MAP2K7/JAK1/IFNAR2/BLNK/STAT2/ACP5/TAB1/CHUK/PPP3CB/TEC1/TYK2/MAP2K6/PPP3CC/ITPR1/TRAF6/IKBKG/GAB2/IL1R1	1.70499485221663
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	38/2885	98/9376	1.2601704806706	PLPP3/SCIN/WASF2/LIMK2/VAV3/PIK3R1/PIP5K1A/DOCK1/PIK3CA/PIK3R3/INPPL1/PIK3CB/ACTR2/ASAP1/AKT3/RPS6KB1/PLCG2/PIP5K1B/AKT2/CRK/MAPK1/GSN/CRKL/RAF1/PIP5K1C/PLD2/ACTR3C/SPHK2/PLD1/DNM2/WASF1/PRKCA/GAB2/PRKCE/LAT/PLA2G6/ACTR3B/PLCG1	1.7260231465716
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	30/2885	75/9376	1.29996533795494	LRP2/HSPA5/CANX/PDIA4/HSP90B1/CREB3L2/GNAQ/ITPR2/GPX8/ATP1A1/ADCY7/ATF6B/GSR/CREB1/TTF1/ADCY6/ADCY2/ATF2/ATP1B3/PRKACB/DUOX1/PLCB1/CREB5/ATP1A4/TTF2/PRKACA/ADCY9/PRKCA/ITPR1/CREB3L4	1.73875993805166
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	74/2885	205/9376	1.17313945132519	JUN/CDK6/PDIA3/PSMD1/GADD45B/CALR/BCL2/RBPJ/MDM2/MAPK14/PIK3R1/SKP2/SIN3A/NEDD4/TAPBP/PIK3CA/MAVS/PIK3R3/PIK3CB/TAB2/NFKBIA/USP7/HES1/CASP3/AKT3/NFKB1/PLCG2/POLK/EIF2AK2/HDAC2/CDKN1A/IFNAR1/CCND1/AKT2/MAPK8/E2F3/IKBKB/HLA-E/IRF3/MAP3K7/MAP2K4/CDKN1B/GADD45A/GADD45G/TAPBPL/MAP2K7/TP53/JAK1/IFNAR2/TRAF5/RIPK1/BCL2L11/STAT3/RB1/IRAK4/CCND3/BLNK/STAT2/TAB1/TBK1/CHUK/MYC/TYK2/CCND2/MYD88/MAP2K6/TRAF3/APAF1/SAP30L/TRAF6/IKBKG/NCOR2/IKBKE/CD58	1.67096503783959
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	41/2885	107/9376	1.24529389850824	SLC2A1/CREB3L2/PHKB/GNAQ/ITPR2/CAMK2G/EP300/PPP4R3A/CREBBP/CPT1A/PPP3CA/PRKAB2/PDE3B/G6PC3/ACACA/AKT3/CREB1/PHKA2/AKT2/PPARA/ADCY2/ATF2/PRKACB/PPP4R3B/PLCB1/PRKAA1/PYGB/SIRT1/SIK2/PPP3CB/CREB5/PHKG2/PRKACA/PPP3CC/PRKAA2/ITPR1/PHKA1/PRKAB1/CREB3L4/CRTC2/PHKG1	1.7012374551403
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	134/2885	388/9376	1.1223927531312	LRP1/APP/SLC39A10/MT-ND6/MME/LRP5/KIF5B/RTN4/PSMD1/MT-ND4L/GNAQ/NCSTN/ITPR2/MT-ND1/MT-CO2/MT-ND4/COX6A1/MT-ND3/MT-ND2/MT-CYB/MT-CO3/MT-ND5/MT-CO1/ATP2A2/ATF6/ADAM10/RB1CC1/DVL3/SLC39A7/KRAS/FZD5/MT-ATP6/FZD6/SLC11A2/PIK3R1/GSK3B/ADAM17/XBP1/FZD3/PIK3CA/IRS2/DDIT3/NDUFS1/IDE/INSR/PPP3CA/PIK3R3/NDUFB9/MT-ATP8/PIK3CB/APC/PSEN1/CSNK1A1/CASP3/FZD10/AKT3/NFKB1/ATG14/SLC39A1/MTOR/EIF2AK2/ULK2/AKT2/APH1A/BRAF/MAPK8/WIPI2/WIPI1/CTNNB1/WNT4/IKBKB/ATG2B/ATG2A/CAPN1/CSNK2A1/SLC39A9/MAPK1/PIK3C3/PLCB1/LRP6/HRAS/BACE2/PSEN2/RTN3/MAP2K7/UQCRC1/PSMA6/EIF2AK3/ERN1/KLC1/NRBF2/WNT5A/AXIN2/RAF1/PIK3R4/SLC39A3/BECN1/ULK1/SLC39A8/DVL1/SLC39A13/CHUK/NDUFA3/BACE1/MCU/WNT2B/PPP3CB/ARAF/FZD1/WNT3/KLC4/ATG13/PPP3CC/CAPN2/APAF1/FZD8/IRS1/APOE/CHRM5/DVL2/ITPR1/SLC39A6/IKBKG/SLC39A11/PSMA8/FRAT2/AXIN1/KLC2/AMBRA1/WNT7A/CHRM3/AGER/APH1B/MAP3K5	1.64150714459841
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	14/2885	31/9376	1.46770280091687	GLDC/ACSS1/CAT/GLUL/ACO1/ACO2/CS/PGP/PCCB/AMT/PCCA/ACSS2/MCEE/GLYCTK	1.7388571569902
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	9/2885	18/9376	1.62495667244367	ACSL3/FASN/ACACA/ACSL4/ACSL1/CBR4/OXSM/ACSL5/ACSF3	1.76928332218435
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	24/2885	60/9376	1.29996533795494	KRAS/MAPK14/PIK3R1/PIK3CA/PPP3CA/PIK3R3/PTK2/PIK3CB/AKT3/PLCG2/NFATC2/AKT2/PXN/MAPK1/HRAS/RAC3/RAF1/PPP3CB/SPHK2/MAPKAPK2/PPP3CC/PRKCA/SRC/PLCG1	1.55394162801676
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	34/2885	89/9376	1.24153992950753	EGFR/GJA1/ADRB1/GNAQ/ITPR2/KRAS/TJP1/ADCY7/MAP3K2/PDGFD/SOS1/GNAI1/GNAI2/GNA11/SOS2/ADCY6/ADCY2/PRKACB/MAPK1/CSNK1D/PLCB1/HRAS/PDGFB/RAF1/PDGFA/PDGFC/PRKACA/LPAR1/ADCY9/PRKCA/ITPR1/MAPK7/SRC/MAP2K5	1.52633181976697
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	83/2885	238/9376	1.13337314128424	EGFR/MET/NF1/RASA1/IGF1R/GAB1/KRAS/FGFR2/EFNA5/GNG12/PIK3R1/EFNA1/FOXO4/PDGFD/KSR1/PIK3CA/RAB5B/RASAL2/REL/INSR/PIK3R3/RASA2/PIK3CB/PAK6/PTPN11/SOS1/RALGAPB/EXOC2/AKT3/STK4/RALBP1/NFKB1/PLCG2/SHC1/RALGAPA1/GNB4/SHOC2/AKT2/RALGAPA2/ETS2/MAPK8/EPHA2/TIAM1/SOS2/MRAS/IKBKB/GNB1/PRKACB/ANGPT1/MAPK1/HRAS/BCL2L1/PLCE1/RGL1/RAC3/PLA2G12A/ABL2/PDGFB/RAF1/ABL1/PLD2/PDGFA/RALGDS/TBK1/CHUK/BDNF/PDGFC/FGFR1/PLD1/PAK4/PRKACA/GNG10/EFNA4/BRAP/PRKCA/IKBKG/GAB2/PGF/LAT/PLA2G6/NTF4/FGF2/PLCG1	1.38942152947648
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	9/2885	19/9376	1.5394326370519	GLDC/DHTKD1/OGDH/DBT/BCKDHB/AMT/LIAS/DLST/DLAT	1.56909214015182
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	28/2885	73/9376	1.2465421048883	RANBP2/AFF4/SERINC3/EP300/FURIN/CCNT1/XPO1/CREBBP/HGS/ELL/CPSF7/NUP153/BICD2/SUPT5H/CCNT2/SERINC5/PDCD6IP/KAT2B/NELFA/VPS4B/TNPO3/MDFIC/NELFCD/MAP1S/KAT2A/TRIM5/NELFB/MLLT3	1.40975538268727
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	34/2885	91/9376	1.21425333765022	FOS/JUN/KRAS/VAV3/NFATC3/PIK3R1/GSK3B/PIK3CA/PPP3CA/PIK3R3/INPPL1/PIK3CB/NFKBIA/SOS1/AKT3/NFKB1/PLCG2/NFATC2/AKT2/SOS2/IKBKB/MAPK1/HRAS/MALT1/RAC3/RAF1/BLNK/CD81/CHUK/PPP3CB/PPP3CC/IKBKG/PTPN6/BANK1	1.36917853075169
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	8/2885	17/9376	1.52937098582934	MTR/TXNRD1/TXNRD2/SEPSECS/PAPSS1/TXNRD3/PSTK/MARS2	1.45637298337593
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	40/2885	110/9376	1.18178667086813	EGFR/TFRC/SLC2A1/EPAS1/IGF1R/CAMK2G/EP300/BCL2/PIK3R1/CREBBP/PIK3CA/INSR/PIK3R3/PIK3CB/IFNGR1/AKT3/ERBB2/RPS6KB1/NFKB1/PLCG2/MTOR/LTBR/EDN1/CDKN1A/AKT2/ARNT/ANGPT1/CDKN1B/MAPK1/VHL/CUL2/STAT3/MKNK2/MKNK1/EGLN1/HIF1A/PDK1/PRKCA/ENO3/PLCG1	1.27854192404325
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	75/2885	217/9376	1.12324193947719	EGFR/FOS/ADRB1/JUN/HSP90B1/CREB3L2/KPNB1/JAG1/KRAS/BCL2/KPNA6/ADCY7/PIK3R1/KLF5/XIAP/ATF6B/PIK3CA/MGST3/PIK3R3/PIK3CB/SOS1/AKT3/RXRA/RPS6KB1/NFKB1/CREB1/MTOR/GNAI1/RPS6KA3/MGST2/GNAI2/CCND1/AKT2/EPHX2/KPNA4/SOS2/ARNT/ADCY6/NOTCH2/PPARA/ADCY2/ATF2/PRKACB/MAPK1/KPNA3/HRAS/PAQR7/EPHX1/KPNA1/STAT3/AHR/RAF1/RB1/STAT5B/CCND3/KPNA5/RXRB/ARRB1/GSTM3/MYC/CREB5/KLF4/PRKACA/GSTM2/ADCY9/PRKCA/ESR2/IKBKE/JAK2/SRC/GSTO2/CREB3L4/RPS6KA6/CDC25A/FGF2	1.22452344334422
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	59/2885	168/9376	1.14133861516877	CSF3R/EGFR/IL6ST/IL10RB/PRLR/LIFR/EP300/BCL2/PIK3R1/MCL1/CSF2RA/PIAS1/CREBBP/GHR/PIK3CA/PIK3R3/PIK3CB/PTPN11/SOCS1/SOS1/IFNGR1/AKT3/SOCS7/MTOR/CDKN1A/IFNAR1/IL4R/SOCS5/CCND1/AKT2/SOCS6/SOS2/SOCS4/HRAS/JAK1/BCL2L1/IFNAR2/SOCS2/PDGFB/STAT3/RAF1/STAT5B/CCND3/PTPN2/STAT2/PDGFA/MYC/IL13RA1/TYK2/STAM2/IL11RA/CCND2/PIAS4/CISH/PIAS3/PTPN6/JAK2/PIAS2/IL15RA	1.23235422889117
NA	NA	hsa04519	Cadherin signaling	135/2885	404/9376	1.08598589494998	CDH1/EGFR/MET/DSC2/DSC3/GJA1/CTNND1/DSG2/DSP/IGF1R/LRP5/ACTN4/TEAD1/GABRE/ROCK1/RERE/TMC5/TCF7L2/NCSTN/LATS2/FAT1/PCDH11X/TAOK1/ADAM10/DVL3/VCL/KRAS/TJP1/LIMA1/EP300/FZD5/MYO7A/DAAM1/TAOK3/MYO1C/FZD6/NCKAP1/MAPK14/ROCK2/AMOTL1/YAP1/VAV3/GSK3B/RYK/KRT80/CREBBP/FZD3/CYFIP2/CYFIP1/ABI2/PTK2/WWC1/APC/AMOTL2/EVL/NFKBIA/ACTR2/GABRA4/PSEN1/MPDZ/CDH3/SAV1/CSNK1A1/FZD10/ERBB2/PKP2/ATN1/NFKB1/TEAD3/LATS1/JUP/SHOC2/APH1A/ENAH/MAPK8/WWTR1/TMC4/ACTN1/MRAS/YWHAG/TMC1/MYO1D/CTNNB1/WNT4/IKBKB/ARHGAP35/FMN1/MAPK1/PRICKLE1/PCDHGC3/MOB1B/LRP6/HRAS/PCDH11Y/PSEN2/RAC3/WNT5A/AXIN2/VANGL1/RAF1/FAT3/LIMD1/DVL1/ACTR3C/CDH26/CHUK/FGFR1/TAOK2/WNT2B/CELSR2/CDH12/AJUBA/PRICKLE2/FZD1/WNT3/NF2/WASF1/PCDHGA10/PRICKLE4/FZD8/MYO1B/LHFPL2/TCF7/CDH5/DVL2/CDH24/IKBKG/WTIP/AXIN1/ANKRD6/TCF7L1/WNT7A/ACTR3B/GABRB1/APH1B	1.17781209090486
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	27/2885	72/9376	1.21871750433276	ADAR/MAPK14/MAP3K1/MAVS/DDX3X/NFKBIA/NFKB1/MAPK8/ATG12/IKBKB/CYLD/IRF3/MAP3K7/RIPK1/SIKE1/IFIH1/OTUD5/ZNFX1/TBK1/CHUK/NLRX1/TRAF3/TKFC/TRAF6/IKBKG/IKBKE/TRIM25	1.24198880574321
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	15/2885	37/9376	1.31753243711649	RIMKLB/GFPT1/GLUL/GLUD1/GOT2/PPAT/ALDH4A1/ALDH5A1/ASS1/GOT1/GLUD2/ABAT/GLS/CAD/CPS1	1.29015388172673
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	38/2885	105/9376	1.17615911529256	JUN/ITPR2/KRAS/MDM2/MAPK14/NFATC3/PIK3R1/ARHGEF12/KSR1/PIK3CA/PPP3CA/PIK3R3/PIK3CB/NFKBIA/PTPN11/AKT3/NFKB1/PLCG2/NFATC2/AKT2/MAPK8/MRAS/IKBKB/CYLD/MAPK1/HRAS/MALT1/RAF1/STAT2/CHUK/PPP3CB/MAPKAPK2/PPP3CC/PYCARD/ITPR1/IKBKG/IKBKE/SRC	1.21015004668741
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	10/2885	23/9376	1.41300580212493	MLH3/MSH3/MSH6/RFC1/RPA1/MSH2/RPA4/MLH1/POLD1/PMS2	1.32204837326204
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	11/2885	26/9376	1.37496333822157	SLC19A1/SLC19A3/SLC52A3/LMBRD1/SLC5A6/SLC19A2/ABCD4/SLC46A1/BTD/ABCC1/MMACHC	1.27635774456815
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	7/2885	15/9376	1.5166262276141	HEXA/HEXB/GLB1/SLC33A1/B3GALT4/ST3GAL2/ST3GAL1	1.33494600361616
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	8/2885	18/9376	1.44440593106104	MTR/LMBRD1/ABCD4/HCFC1/ZNF76/MTRR/MMAA/MMACHC	1.25813522244933
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	15/2885	38/9376	1.28286053087659	KRAS/ATP1A1/PIK3R1/PDPK1/PIK3CA/INSR/PIK3R3/PIK3CB/NEDD4L/ATP1B3/MAPK1/ATP1A4/PRKCA/IRS1/NR3C2	1.16476941442744
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	17/2885	44/9376	1.25564833779738	PARP1/TDG/PNKP/NEIL1/MBD4/RFC1/LIG3/PARP2/POLE/POLL/MUTYH/POLG/PARG/POLG2/TDP1/POLD1/PARP4	1.13314291812226
NA	NA	hsa04517	IgSF CAM signaling	100/2885	299/9376	1.0869275400961	NRP2/CDH1/APP/ITGB1/MYH10/NRP1/IQGAP1/RASA1/PTPRF/CADM1/ACTN4/ANK3/LMO7/SPTBN1/SORBS1/SPTAN1/ERC1/NRCAM/PPFIA1/EPB41L3/JAM3/VCL/PLXNA1/TJP1/MTSS1/PRKCI/F11R/SRGAP1/PARD3/MAPK14/RDX/VAV3/DYNLL2/NLGN4X/PIK3R1/GSK3B/RAPGEF2/TRIO/TJP2/PDPK1/PIK3CA/GRIP1/BAIAP2/PIK3R3/PTK2/MAGI1/CD2AP/PIK3CB/WASL/PLXNA2/PAK6/ACTR2/PTPN11/MPDZ/AKT3/PARD6B/PLCG2/CNTNAP2/NCK2/AKT2/ROBO1/MAPK8/MYH9/PXN/NCK1/ACTN1/MYLK3/CTNNB1/EPB41L2/MAPK1/RAPGEF6/SRGAP2/IL1RAPL2/BCAR1/NLGN1/ABL1/ACTR3C/CASK/FGFR1/GIT1/SRGAP3/CASKIN2/PAK4/UNC5B/PRKCA/PTPRZ1/MAGI2/TRAF6/PTPN6/PARD6G/TRPC6/MAP2/PLXNA3/SRC/CABLES2/NTN1/PVR/ACTR3B/MYLK4/PLCG1	1.01841446416044
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	24/2885	65/9376	1.1999680042661	PLPP3/LPIN2/AGPAT1/DGKH/GPAM/DGKA/DGKD/AGPAT3/GPAT4/PLPP5/PNPLA2/GLA/LIPG/LPIN1/DGAT1/MBOAT2/AGK/AGPAT4/LCLAT1/DGKZ/TKFC/AGPAT5/GLYCTK/ABHD16A	1.07850402349044
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	26/2885	71/9376	1.19010911221227	EGFR/MET/SLC2A1/SLC1A5/IDH1/KRAS/FGFR2/PIK3R1/PIK3CA/PIK3R3/PIK3CB/AKT3/ERBB2/MTOR/AKT2/PTEN/MAPK1/HRAS/TP53/RAF1/HIF1A/PDK1/FGFR1/MYC/GLS/SIRT6	1.07195526514559
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	6/2885	13/9376	1.49996000533262	PRKDC/RAD50/DCLRE1C/POLL/LIG4/POLM	1.2025473091363
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	13/2885	33/9376	1.28026889344047	IDH1/DHTKD1/OGDH/DBT/BCAT1/GOT2/ACO1/ACO2/CS/BCKDHB/GOT1/DLST/DLAT	1.07520539966941
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	48/2885	139/9376	1.1222722342057	EGFR/FOS/NCOA3/JUN/HSP90B1/CTSD/CREB3L2/GNAQ/ITPR2/KRAS/BCL2/NCOA2/ADCY7/PIK3R1/NCOA1/ATF6B/PIK3CA/PIK3R3/PIK3CB/SOS1/HSPA1B/AKT3/HSPA8/CREB1/SHC1/GNAI1/SP1/GNAI2/AKT2/HSPA1A/SOS2/ADCY6/ADCY2/ATF2/PRKACB/EBAG9/MAPK1/PLCB1/HRAS/RAF1/HBEGF/CREB5/PRKACA/ADCY9/ESR2/ITPR1/SRC/CREB3L4	0.968216587197457
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	68/2885	201/9376	1.09947317140468	MET/PBX1/SPINT1/FUS/IGF1R/DUSP6/FUT8/GADD45B/DDX5/JMJD1C/NCOR1/KMT2A/MDM2/ID2/ATM/CCNT1/SIN3A/TGFBR2/BIRC2/DDIT3/REL/NFKBIZ/PTK2/ASPSCR1/ETV6/ELK4/RXRA/NFKB1/EWSR1/POLK/HDAC2/SP1/CDKN1A/JUP/BMI1/CCNT2/KLF3/SS18/CEBPA/PPARG/CDKN1B/GADD45A/GADD45G/SIX4/TP53/BCL2L1/ETV5/SS18L1/KDM6A/MEN1/TFE3/SMAD1/PLAU/MAX/PDGFA/RXRB/PROM1/MYC/DOT1L/MEIS1/CCND2/BMP2K/PER2/LDB1/MLLT3/ZBTB17/PML/NR4A3	0.950394028671056
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	25/2885	69/9376	1.17750483510411	KRAS/MAPK14/VAV3/PIK3R1/PDPK1/PIK3CA/PIK3R3/PIK3CB/SOS1/AKT3/PLCG2/AKT2/MAPK8/SOS2/MAP2K4/MAPK1/HRAS/MAP2K7/RAC3/RAF1/MAP2K6/PRKCA/GAB2/LAT/PLCG1	0.986580706581833
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	38/2885	109/9376	1.13299731289651	IL6ST/FOS/JUN/GATA3/TGFBR1/MAPK14/NFATC3/TGFBR2/SMAD2/SMAD4/PPP3CA/NFKBIA/IFNGR1/RXRA/NFKB1/MTOR/NFATC2/IL4R/MAPK8/IKBKB/MAPK1/JAK1/STAT3/AHR/STAT5B/RXRB/HIF1A/CHUK/PPP3CB/TYK2/SMAD3/PPP3CC/RORA/IKBKG/IL1R1/JAK2/LAT/PLCG1	0.931084884675464
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	36/2885	103/9376	1.13589204287325	FOS/JUN/GNAQ/CALR/TGFBR1/CFLAR/MAPK14/PIK3R1/TGFBR2/PIK3CA/SMAD2/PIK3R3/PIK3CB/NFKBIA/IFNGR1/AKT3/PPP2R2A/NFKB1/GNAI1/GNAI2/AKT2/MAPK8/GNA11/IKBKB/PPP2R2B/MAP2K4/MAPK1/PLCB1/PPP2R2D/PPP2R1A/IRAK4/CHUK/MYD88/PPP2R1B/TRAF6/IKBKG	0.924496459510796
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	33/2885	94/9376	1.14092702533279	FOS/JUN/HSP90B1/FOSB/JUND/USP25/MAPK14/GSK3B/TAB3/ANAPC5/TAB2/NFKBIA/CASP3/TRAF4/NFKB1/MAPK6/MAPK8/IKBKB/MAP3K7/MAPK1/MAPK4/TRAF5/TBK1/CHUK/IL17RA/IL17RC/TRAF3/IL17RE/TRAF6/IKBKG/TRAF3IP2/MAPK7/IKBKE	0.915461684439637
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	38/2885	110/9376	1.12269733732472	IGF1R/KRAS/CPEB4/ADCY7/MAPK14/PIK3R1/PIK3CA/PIK3R3/PIK3CB/ANAPC5/PDE3B/ANAPC4/AKT3/GNAI1/RPS6KA3/GNAI2/AKT2/BRAF/MAPK8/ANAPC1/ADCY6/ADCY2/PRKACB/CDC23/MAPK1/CDC16/CDC27/RAF1/CPEB2/FZR1/ARAF/PRKACA/ANAPC7/ADCY9/CPEB3/RPS6KA6/CDC25A/ANAPC2	0.862954852459631
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	16/2885	43/9376	1.20927008181855	HADHA/ACSL3/CPT2/CPT1A/ACOX1/ACADS/ACADVL/ACSL4/ACADL/ACADSB/ACADM/ACSL1/EHHADH/ACSL5/CYP2U1/GCDH	0.916924297810178
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	56/2885	166/9376	1.09635630911862	ATP2B1/ADRB1/GTF2I/GNA12/CREB3L2/ROCK1/ATP2B4/GNAQ/ITPR2/ATP2A2/PPP1R12A/ATP1A1/ADCY7/ROCK2/NFATC3/ATF6B/IRS2/INSR/PPP3CA/PDE3B/RGS2/AKT3/CREB1/GNAI1/EDNRB/GNAI2/NFATC2/AKT2/GNA11/MYLK3/ADCY6/MEF2A/ADCY2/ATF2/ATP1B3/GNA13/MAPK1/PLCB1/RAF1/PPP3CB/CREB5/ATP1A4/SRF/ADCY9/PPP3CC/IRS1/CNGB1/ITPR1/SLC8A1/MEF2D/TRPC6/KCNMB3/PRKCE/CREB3L4/MYLK4/ADRA2B	0.835039707736608
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	120/2885	368/9376	1.0597543515937	HSPA5/MT-ND6/TPR/FUS/KIF5B/PSMD1/MT-ND4L/RANBP2/MT-ND1/MT-CO2/MT-ND4/COX6A1/MT-ND3/MT-ND2/MT-CYB/MT-CO3/MT-ND5/MT-CO1/ATF6/RB1CC1/GPX8/C9orf72/BCL2/ATXN2/SETX/MT-ATP6/MAPK14/CAT/POM121/POM121C/SPG11/XBP1/DDIT3/NDUFS1/PPP3CA/NDUFB9/MT-ATP8/NUP210/DCTN4/NUP58/DCTN5/PFN2/UBQLN1/DCTN1/CASP3/NUP153/NUP205/NUP98/ATG14/MTOR/ULK2/NUP155/SRSF7/NXF1/OPTN/WIPI2/NUP133/TARDBP/NUP160/DNAH14/NUP214/WIPI1/NUP107/ATG2B/ATG2A/NCBP1/NDC1/ALS2/VCP/DERL1/PIK3C3/TP53/UQCRC1/CCS/PSMA6/BCL2L1/EIF2AK3/ERN1/KLC1/NUP50/NRBF2/VAPB/ERBB4/PINK1/ATXN2L/PIK3R4/HDAC6/UBQLN2/NUP88/BECN1/FIG4/ULK1/NUP188/NUP62/TBK1/SMCR8/NDUFA3/DAXX/MCU/PPP3CB/NUP43/SIGMAR1/DNAL1/SEH1L/KLC4/NUP85/MAP2K6/ATG13/PPP3CC/APAF1/ACTR1B/GLE1/PSMA8/UBQLN4/NRG4/KLC2/AMBRA1/TOMM40L/SLC1A2/MAP3K5	0.779618257521748
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	23/2885	65/9376	1.14996933742168	PBX1/CREB3L2/GNAQ/ITPR2/NCEH1/ADCY7/ATF6B/LDLR/CREB1/SP1/GNA11/NR4A1/ADCY6/ADCY2/ATF2/PRKACB/PLCB1/PDE8A/CREB5/PRKACA/ADCY9/ITPR1/CREB3L4	0.808842066525016
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	75/2885	227/9376	1.07375991571168	SLC26A2/EGFR/MET/MT-ND6/FOS/JUN/MT-ND4L/MT-ND1/MT-CO2/MT-ND4/COX6A1/MT-ND3/MT-ND2/MT-CYB/MT-CO3/MT-ND5/MT-CO1/KRAS/MT-ATP6/MAPK14/NFE2L2/CAT/PIK3R1/PDPK1/PIK3CA/NDUFS1/MGST3/PIK3R3/PTK2/NDUFB9/MT-ATP8/PIK3CB/NFKBIA/PTPN11/SOS1/AKT3/CBR1/PTPN1/NFKB1/MGST2/AKT2/BRAF/PTEN/FOXO3/MAPK8/EPHX2/SOS2/ARNT/IKBKB/PTPRJ/MAP2K4/MAPK1/HRAS/MAP2K7/UQCRC1/EPHX1/ABL2/AHR/RAF1/ABL1/PRKD2/PLD2/HIF1A/CHUK/NDUFA3/GSTM3/PLD1/ARAF/GSTM2/KEAP1/IKBKG/SRC/GSTO2/SLC26A6/MAP3K5	0.749979286601831
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	9/2885	23/9376	1.27170522191244	GLUL/GLUD1/GOT2/ASS1/GOT1/GLUD2/GLS/CAD/CPS1	0.869739468036541
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	32/2885	93/9376	1.11824975307952	FOS/JUN/MAML2/JAG1/GATA3/RBPJ/MAPK14/NOTCH3/MAML3/NFATC3/PPP3CA/NFKBIA/IFNGR1/NFKB1/NFATC2/IL4R/MAPK8/MAML1/NOTCH2/IKBKB/MAPK1/JAK1/STAT5B/CHUK/PPP3CB/TYK2/PPP3CC/JAG2/IKBKG/JAK2/LAT/PLCG1	0.764012183094177
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	17/2885	47/9376	1.175500571555	PIK3R1/PIK3CA/IRS2/INSR/PIK3R3/PIK3CB/SOCS1/MTOR/MAPK8/SOCS4/IKBKB/MAPK1/PRKCZ/SOCS2/MAFA/IRS1/PRKCE	0.804104809994539
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	12/2885	32/9376	1.21871750433276	PMAIP1/BIRC6/BCL2/XIAP/BIRC2/CASP3/MAPK8/BCL2L1/BCL2L11/BECN1/APAF1/BBC3	0.826218392125605
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	39/2885	115/9376	1.10214452565745	FOS/CREB3L2/GNAQ/ITPR2/KRAS/CAMK2G/BCL2/ADCY7/GNG12/PIK3R1/PIK3CA/PIK3R3/PIK3CB/AKT3/CREB1/GNAI1/GNAI2/GNB4/AKT2/GNA11/ADCY6/ADCY2/GNB1/PRKACB/MAPK1/PLCB1/HRAS/KCNJ2/CREB5/PRKACA/GNG10/ADCY9/PRKCA/CHRM5/ITPR1/JAK2/ACHE/CREB3L4/CHRM3	0.7347469914138
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	62/2885	187/9376	1.07751137637976	JUN/PKN2/ITPR2/ANTXR2/TRPM7/BCL2/MAPK14/XIAP/TAB3/BIRC2/CTSB/MAVS/DNM1L/TAB2/NFKBIA/NEK7/TP53BP1/NFKB1/IFNAR1/MAPK8/DHX33/ATG12/IKBKB/IRF3/MAP3K7/MAPK1/NAIP/PLCB1/IFI16/CARD8/JAK1/GABARAPL1/BCL2L1/IFNAR2/TRAF5/MFN2/RIPK1/GBP3/IRAK4/BRCC3/STAT2/TAB1/P2RX7/TBK1/RNASEL/CHUK/MFN1/MCU/NLRX1/TYK2/GBP1/PANX1/MYD88/TRAF3/CARD6/PYCARD/ITPR1/TRAF6/IKBKG/NOD1/IKBKE/ANTXR1	0.71376437625721
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	37/2885	109/9376	1.10318159413607	FOS/JUN/MAPK14/TLR3/PIK3R1/PIK3CA/PIK3R3/PIK3CB/TAB2/NFKBIA/AKT3/NFKB1/IFNAR1/AKT2/MAPK8/IKBKB/IRF3/MAP3K7/MAP2K4/MAPK1/MAP2K7/JAK1/IFNAR2/RIPK1/IRAK4/STAT2/TAB1/TBK1/CHUK/TYK2/MYD88/MAP2K6/TRAF3/TRAF6/IKBKG/IKBKE/TIRAP	0.722351606844673
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	26/2885	76/9376	1.11181246009304	SLC27A2/OLR1/SORBS1/ACSL3/CPT2/CPT1A/PDPK1/ACOX1/RXRA/SLC27A6/HMGCS1/PPARG/ACSL4/PPARA/ACADL/PPARD/ACADM/ACSL1/RXRB/EHHADH/SLC27A4/ME1/SCD5/ACSL5/NR1H3/SLC27A1	0.652466573352054
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	5/2885	12/9376	1.35413056036973	GGCX/COQ4/VKORC1L1/COQ6/COQ7	0.81832547176052
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	44/2885	133/9376	1.07515930206799	FOS/KIF5B/CREB3L2/GNAQ/ITPR2/CAMK2G/MAPK14/GNG12/GSK3B/CLOCK/ATF6B/PPP3CA/AKT3/PPP2R2A/CREB1/GNAI1/GNAI2/GNB4/AKT2/PPP2R5E/MAPK8/PPP2R5C/ATF2/PPP2R3A/PPP2R2B/MAOA/GNB1/PRKACB/PPP2R3B/PLCB1/PPP2R2D/PPP2R1A/ARRB1/PPP3CB/CREB5/PPP2R5A/PRKACA/GNG10/PPP3CC/PRKCA/PPP2R5D/PPP2R1B/ITPR1/CREB3L4	0.581975664570375
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	29/2885	86/9376	1.09590101164806	ITGA6/ITGB4/DAG1/ITGAV/ITGB1/DSC2/GJA1/DSG2/ITGB5/DSP/ITGB8/TCF7L2/ATP2A2/DMD/SSPN/SGCE/ITGB6/SNTB1/PKP2/JUP/SNTB2/CTNNB1/ITGA3/SGCB/LAMA1/TCF7/SLC8A1/TCF7L1/CACNA2D3	0.595617294455721
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	18/2885	52/9376	1.12497000399947	LRP2/LRP1/LRPAP1/ABCA1/NCEH1/MYLIP/LIPA/NPC1/LDLR/SORT1/SOAT1/LIPG/LDLRAP1/VAPB/LCAT/STARD3/APOE/APOC1	0.602433432683143
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	20/2885	59/9376	1.10166554063978	ADRB1/ADCY7/PIK3R1/PIK3CA/IRS2/INSR/PIK3R3/PIK3CB/PDE3B/AKT3/GNAI1/GNAI2/AKT2/PNPLA2/ADCY6/ADCY2/PRKACB/PRKACA/ADCY9/IRS1	0.52223319654668
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	56/2885	173/9376	1.05199507117741	CDK6/ADAR/EP300/DNAJC3/PABPN1/KPNA6/DNAJB1/TLR3/PIK3R1/XPO1/CREBBP/PIK3CA/MAVS/PIK3R3/PIK3CB/NFKBIA/IFNGR1/CASP3/AKT3/NFKB1/NUP98/EIF2AK2/IFNAR1/NXF1/AKT2/HNRNPUL1/IKBKB/IRF3/MAPK1/JAK1/IFNAR2/KPNA1/RAF1/IFIH1/IRAK4/CCND3/STAT2/KPNA5/TBK1/RNASEL/CHUK/TNFRSF10B/NLRX1/TYK2/MYD88/TRAF3/APAF1/PRKCA/PYCARD/IKBKG/IKBKE/JAK2/TRIM25/PML/RSAD2/TNFSF10	0.460175253245202
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	18/2885	53/9376	1.1037441548674	ATP2B1/CLTC/ATP2B4/GNAQ/AP2A2/ATP1A1/AP2A1/AP2B1/ADCY6/ATP1B3/PRKACB/PLCB1/ATP1A4/PRKACA/DNM2/ADCY9/PRKCA/SLC8A1	0.504924532693746
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	13/2885	38/9376	1.11181246009304	SIRT7/NNT/NT5C2/NUDT12/NADSYN1/BST1/SIRT1/NADK2/NADK/NMNAT1/SIRT6/SIRT2/NUDT13	0.460423846567287
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	22/2885	67/9376	1.06713572518689	GNAQ/ITPR2/KRAS/CAMK2G/EP300/CREBBP/PPP3CA/RPS6KA3/BRAF/PRKACB/MAPK1/PLCB1/HRAS/RAF1/PPP3CB/ARAF/PRKACA/PPP3CC/PRKCA/ITPR1/RPS6KA6/RAPGEF3	0.367656554616335
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	8/2885	23/9376	1.13040464169995	MME/ENPEP/ATP6AP2/CTSA/LNPEP/PRCP/ACE2/ANPEP	0.417430562811037
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	74/2885	235/9376	1.02337696817729	MT-ND6/SMARCA2/CREB3L2/MT-ND4L/MT-ND1/MT-CO2/MT-ND4/COX6A1/MT-ND3/MT-ND2/MT-CYB/MT-CO3/MT-ND5/MT-CO1/ARID1A/ACSL3/KRAS/CPT2/MT-ATP6/ADCY7/MAPK14/SMARCC1/CPT1A/NDUFS1/NDUFB9/PRKAB2/MT-ATP8/COX19/FRS2/SMARCA4/ARID1B/SOS1/SMARCD1/RPS6KB1/CREB1/MTOR/RPS6KA3/PNPLA2/SMARCD2/SOS2/ADCY6/COX15/PPARG/ACSL4/ADCY2/ATF2/TSC2/PRKACB/TSC1/KDM3B/SMARCE1/SMARCC2/HRAS/UQCRC1/PRKAA1/ACSL1/RPTOR/COX10/NDUFA3/FGFR1/CREB5/NDUFAF7/COX18/PRKACA/ADCY9/PRKAA2/ACSL5/SLC25A29/SIRT6/PRKAB1/CREB3L4/RPS6KA6/SLC25A20/MAP3K5	0.24195132494789
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	37/2885	116/9376	1.03661029104165	GLDC/ACSS1/IDH1/CAT/OGDH/PC/PGD/ACOX1/GLUD1/GOT2/ACO1/ADPGK/ACO2/RPIA/H6PD/ACADS/CS/PGP/GOT1/GLUD2/PCCB/AMT/PCCA/ACSS2/ME2/SDSL/SUCLG2/HIBCH/MCEE/ME1/DLST/ALDH6A1/DLAT/TKFC/GLYCTK/ENO3/CPS1	0.264502283093082
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	37/2885	116/9376	1.03661029104165	ITGB1/CTNND1/CLDN4/ACTN4/ROCK1/ARHGAP5/JAM3/VCL/F11R/MAPK14/ROCK2/VAV3/PIK3R1/OCLN/PIK3CA/PIK3R3/PTK2/PIK3CB/PTPN11/PLCG2/GNAI1/GNAI2/PXN/ACTN1/CTNNB1/ARHGAP35/BCAR1/CD99L2/CLDN19/CLDN12/CLDN3/CLDN1/PRKCA/CLDN23/CDH5/RAPGEF3/PLCG1	0.264502283093082
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	6/2885	17/9376	1.14702823937201	GLUL/GLUD1/CA8/GLUD2/CA5B/CPS1	0.404495073108803
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	10/2885	30/9376	1.08330444829578	IDH1/OGDH/PC/ACO1/ACO2/ACLY/CS/SUCLG2/DLST/DLAT	0.30466227018939
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	9/2885	27/9376	1.08330444829578	HADHA/ACADS/HMGCS1/ALDH5A1/ABAT/EHHADH/ACSM3/OXCT1/L2HGDH	0.288981630464868
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	7/2885	21/9376	1.08330444829578	PANK3/AASDHPPT/BCAT1/CSAD/COASY/DPYD/PANK1	0.25477610058536
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	11/2885	34/9376	1.05144255275767	POLR2J3/POLR2A/POLR2B/POLR3A/POLR3E/POLR3B/POLR2J2/POLR1A/CRCP/POLR1B/POLR2M	0.20032944187778
Organismal Systems	Nervous system	hsa04730	Long-term depression	19/2885	60/9376	1.02913922588099	IGF1R/GNA12/GNAQ/ITPR2/KRAS/GNAI1/GNAI2/BRAF/GNA11/GNA13/MAPK1/PLCB1/HRAS/PPP2R1A/RAF1/ARAF/PRKCA/PPP2R1B/ITPR1	0.150952961476706
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	27/2885	86/9376	1.0203216315344	SLC2A1/KCNN4/CREB3L2/GNAQ/ATP1A1/CAMK2G/PCLO/ADCY7/ATF6B/VAMP2/CREB1/GNA11/ADCY6/ADCY2/ATF2/ATP1B3/PRKACB/PLCB1/CREB5/ATP1A4/PRKACA/ADCY9/PRKCA/KCNMB3/CCK/CREB3L4/CHRM3	0.126212591352683
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	43/2885	138/9376	1.01265415818954	IGF1R/SLK/ITPR2/CAMK2G/CPEB4/ADCY7/MAPK14/SMC1A/FBXW11/SMC3/PPP3CA/ANAPC5/ANAPC4/RPS6KA3/CUL1/PPP2R5E/ANAPC1/YWHAG/ADCY6/ADCY2/PPP2R5C/PRKACB/CDC23/MAPK1/CDC16/PPP2R1A/CDC27/BTRC/CPEB2/PPP3CB/PPP2R5A/PRKACA/ANAPC7/ADCY9/PPP3CC/CPEB3/PPP2R5D/PPP2R1B/ITPR1/SMC1B/RPS6KA6/ESPL1/ANAPC2	0.0998358605827499
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	10/2885	31/9376	1.04835914351205	HADHA/ACOX1/CSAD/ACADS/DPYD/ABAT/HIBCH/EHHADH/MLYCD/ALDH6A1	0.179792899758126
NA	NA	hsa04981	Folate transport and metabolism	10/2885	31/9376	1.04835914351205	SLC19A1/MTR/FOLR1/SLC46A1/ABCG2/ABCC1/MTHFR/ABCC5/FPGS/ABCC2	0.179792899758126
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	148/2885	480/9376	1.0020566146736	APP/HSPA5/MT-ND6/FUS/LRP5/KIF5B/PSMD1/MT-ND4L/GNAQ/ITPR2/MT-ND1/MT-CO2/MT-ND4/COX6A1/MT-ND3/MT-ND2/MT-CYB/MT-CO3/MT-ND5/MT-CO1/ATP2A2/ATF6/RB1CC1/GPX8/DVL3/C9orf72/KRAS/CAMK2G/FZD5/BCL2/ATXN2/MT-ATP6/FZD6/MAPK14/CAT/UBE2G2/GSK3B/SPG11/XBP1/FZD3/DDIT3/NDUFS1/PPP3CA/NDUFB9/UBA1/MT-ATP8/APC/DCTN4/DCTN5/PSEN1/HTT/GPR37/DCTN1/CSNK1A1/CASP3/FZD10/NFKB1/ATG14/MTOR/ULK2/OPTN/ATXN1/BRAF/MAPK8/WIPI2/TARDBP/DNAH14/WIPI1/CTNNB1/WNT4/ATG2B/ATG2A/CAPN1/ALS2/VCP/CSNK2A1/PRNP/MAPK1/DERL1/PIK3C3/PLCB1/LRP6/HRAS/PSEN2/MAP2K7/UQCRC1/CCS/PSMA6/BCL2L1/EIF2AK3/ERN1/KLC1/NRBF2/VAPB/MFN2/WNT5A/AXIN2/PINK1/RAF1/ATXN2L/PIK3R4/BECN1/FIG4/ULK1/ATXN1L/DVL1/TBK1/SMCR8/ATXN3/BDNF/NDUFA3/DAXX/MFN1/MCU/WNT2B/PPP3CB/SIGMAR1/ARAF/DNAL1/FZD1/WNT3/KLC4/MAP2K6/ATG13/PPP3CC/CAPN2/ZFYVE1/APAF1/PRKCA/FZD8/ACTR1B/CHRM5/UBA7/DVL2/ITPR1/HIP1/PSMA8/FRAT2/AXIN1/KLC2/AMBRA1/TOMM40L/WNT7A/CHRM3/MAP3K10/AGER/PLCG1/MAP3K5	0.030837481648419
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	17/2885	54/9376	1.02312086783491	MTR/DNMT3A/AHCYL1/GCLM/AHCYL2/MAT2A/MAT2B/BCAT1/GOT2/DNMT1/AMD1/GCLC/GOT1/LACC1/MRI1/SDSL/DNMT3B	0.113592381343635
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	9/2885	28/9376	1.04461500371379	ATP6V1B1/ATP6V0A1/ATP6V1C2/ATP6V1A/TCIRG1/ATP6V1E2/ATP6V0A2/ATP6V0A4/ATP6V1B2	0.157617102545356
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	59/2885	193/9376	0.993496825639138	ROCK1/GNAQ/KRAS/PARD3/ADCY7/ROCK2/VAV3/GNG12/PIK3R1/GSK3B/PIK3CA/PIK3R3/PTK2/PIK3CB/NFKBIA/SOS1/AKT3/NFKB1/PLCG2/SHC1/GNAI1/GNAI2/GNB4/AKT2/BRAF/FOXO3/CRK/PXN/TIAM1/SOS2/ADCY6/IKBKB/ADCY2/GNB1/PRKACB/MAPK1/PRKCZ/PLCB1/HRAS/RAC3/BCAR1/STAT3/CRKL/RAF1/STAT5B/STAT2/ARRB1/CHUK/PRKACA/GRK5/GNG10/ADCY9/IKBKG/JAK2/SRC/GRK4/XCR1/CXCR2/PLCG1	-0.0608575553912198
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	47/2885	154/9376	0.991856670192892	ATP2B1/ADRB1/CREB3L2/ATP2B4/GNAQ/SLC9A1/RPS6KA5/ATP2A2/ATP1A1/CAMK2G/BCL2/ADCY7/MAPK14/ATF6B/AKT3/PPP2R2A/CREB1/GNAI1/GNAI2/AKT2/PPP2R5E/ADCY6/ADCY2/PPP2R5C/ATF2/PPP2R3A/PPP2R2B/ATP1B3/PRKACB/MAPK1/PPP2R3B/PLCB1/PPP2R2D/PPP2R1A/CREB5/ATP1A4/PPP2R5A/PRKACA/ADCY9/PRKCA/PPP2R5D/PPP2R1B/SLC8A1/CREB3L4/TNNT2/RAPGEF3/CACNA2D3	-0.0679285850040017
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	47/2885	154/9376	0.991856670192892	EGFR/FOS/JUN/ROCK1/GNAQ/ITPR2/PPP1R12A/KRAS/CAMK2G/ADCY7/ROCK2/PPP1R12B/NFATC3/PPP3CA/PRKAB2/RGS2/RCAN1/GNAI1/CDKN1A/GNAI2/NFATC2/CCND1/MYLK3/ADCY6/ADCY2/PRKACB/MAPK1/PLCB1/HRAS/KCNJ2/CAMKK2/PRKAA1/RAF1/EEF2K/PPP3CB/PRKACA/ADCY9/PPP3CC/PRKCA/PRKAA2/ITPR1/MAPK7/PRKAB1/SRC/MAP2K5/CACNA2D3/MYLK4	-0.0679285850040017
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	12/2885	39/9376	0.999973336888415	GLDC/MTR/AHCYL1/AHCYL2/MAT2A/MAT2B/GART/MTHFD2L/AMT/CHDH/MTHFR/DMGDH	-0.000111235188906436
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	15/2885	49/9376	0.994871432108372	JUN/CREB3L2/FOSB/ATF6B/NFKB1/CREB1/GNAI1/GNAI2/ATF2/MAOA/PRKACB/BDNF/CREB5/PRKACA/CREB3L4	-0.0239952844753523
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	18/2885	59/9376	0.991498986575801	IDH1/GPX8/GCLM/MGST3/GSR/PGD/RRM2B/MGST2/GGT7/TXNDC12/GCLC/GSTK1/LANCL1/GSTM3/GSTM2/ANPEP/GGT1/GSTO2	-0.0436678090380268
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	24/2885	79/9376	0.987315446548055	SLC6A4/CLTC/ATP6V1B1/AP2A2/SLC1A3/AP2A1/VAMP2/ATP6V0A1/AP2B1/ATP6V1H/ATP6V0B/ATP6V1C2/ATP6V1A/TCIRG1/ATP6V1E2/ATP6V0A2/SYT1/NSF/ATP6V0A4/ATP6V1B2/STX2/UNC13B/DNM2/SLC1A2	-0.0754779429314484
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	11/2885	36/9376	0.993029077604468	MCM6/MCM2/MCM3/RFC1/MCM5/RPA1/POLE/POLA1/RPA4/PRIM2/POLD1	-0.0279364232979332
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	27/2885	89/9376	0.985928767550095	ITGA6/ITGB4/LAMB1/DAG1/ITGAV/LAMC1/LAMA5/ITGB1/COL4A2/ITGB5/ITGB8/CD47/COL4A1/FRAS1/FREM2/ITGB6/LAMB4/LAMB2/FN1/ITGA3/HSPG2/NPNT/SV2B/LAMA1/THBS1/VWF/COL2A1	-0.0889185066643779
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	17/2885	56/9376	0.986580836840802	CLK4/CLK1/NFKBIA/HSPA1B/CASP3/HSPA8/NFKB1/BCL2L13/HSPA1A/SAR1B/SAR1A/VCP/NAIP/RAB1B/MYD88/APAF1/PYCARD	-0.0671450857934115
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	30/2885	99/9376	0.984822225723439	GNAQ/ITPR2/CAMK2G/ADCY7/MAPK14/PIK3R1/PIK3CA/PIK3R3/PIK3CB/PLCG2/PRKCH/TRPV4/MAPK8/ADCY6/ADCY2/PRKACB/PLCB1/PRKACA/MAP2K6/ADCY9/PRKCA/TRPV1/F2RL1/ITPR1/IL1R1/PRKCE/SRC/PLA2G6/P2RY2/PLCG1	-0.10121028577023
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	23/2885	76/9376	0.983526407005382	GNAQ/SLC9A1/ITPR2/ATP1A1/CAMK2G/ADCY7/SLC4A2/GNAI1/GNAI2/MYLK3/ADCY6/ADCY2/ATP1B3/PRKACB/PLCB1/KCNJ2/ATP1A4/PRKACA/ADCY9/PRKCA/ITPR1/CHRM3/MYLK4	-0.0961294364067389
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	10/2885	33/9376	0.984822225723439	STX16/VAMP2/GOSR1/STX17/STX7/BET1L/STX6/STX2/VAMP7/VTI1A	-0.0582270285396053
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	47/2885	157/9376	0.972903994966276	FOS/JUN/MT-CO2/COX6A1/MT-CYB/MT-CO3/MT-CO1/MAPK14/PIK3R1/GSK3B/XBP1/PIK3CA/IRS2/DDIT3/NDUFS1/INSR/PIK3R3/NDUFB9/PRKAB2/PIK3CB/CASP3/AKT3/RXRA/NFKB1/AKT2/ITCH/MAPK8/CEBPA/ADIPOR1/IKBKB/PPARG/PPARA/ADIPOR2/UQCRC1/EIF2AK3/ERN1/PRKAA1/BCL2L11/MAP3K11/NDUFA3/SREBF1/MLXIP/PRKAA2/IRS1/PRKAB1/NR1H3/MAP3K5	-0.228252701003817
Organismal Systems	Digestive system	hsa04978	Mineral absorption	18/2885	61/9376	0.958990823081513	ATP2B1/ATP2B4/SLC40A1/TRPM7/ATP1A1/TRPV6/SLC11A2/ATP7B/SLC46A1/SLC31A1/SLC34A2/ATP1B3/ATP7A/SLC30A1/ATP1A4/TRPM6/SLC8A1/SLC26A6	-0.214218652462946
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	29/2885	98/9376	0.961709051038093	ATP2B1/CREB3L2/ATP2B4/GNAQ/ITPR2/ATP1A1/CAMK2G/ADCY7/ATF6B/LDLR/CREB1/GNA11/NR4A1/ADCY6/ADCY2/ATF2/ATP1B3/PRKACB/PLCB1/PRKD2/CREB5/ATP1A4/PRKACA/ADCY9/PRKCA/ITPR1/DAGLB/PRKCE/CREB3L4	-0.254029834753312
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/2885	10/9376	0.974974003466204	SUOX/PAPSS1/BPNT1	-0.05278579244055
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	5/2885	17/9376	0.955856866143338	CSAD/GGT7/ADO/GGT1/FMO4	-0.121443882024762
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	19/2885	65/9376	0.949974670043994	KCNN4/GNAQ/ITPR2/KRAS/PIK3R1/PIK3CA/PIK3R3/PIK3CB/AKT3/AKT2/GNA11/MAPK1/PLCB1/HRAS/RAF1/ARRB1/PRKCA/ESR2/ITPR1	-0.26980576133667
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	39/2885	134/9376	0.945870301870198	MYH10/GNA12/ROCK1/GNAQ/ITPR2/PPP1R12A/ADCY7/ROCK2/PPP1R12B/ARHGEF12/CALD1/ADM/EDN1/PRKCH/BRAF/GNA11/MYH9/MYLK3/ADCY6/ADCY2/PRKACB/GNA13/MAPK1/PLCB1/PLA2G12A/RAF1/ARHGEF11/RAMP1/ARAF/PRKACA/CALCRL/ADCY9/PRKCA/ADORA2B/ITPR1/KCNMB3/PRKCE/PLA2G6/MYLK4	-0.420734150474838
Organismal Systems	Immune system	hsa04611	Platelet activation	36/2885	126/9376	0.928546669967814	ITGB1/ROCK1/GNAQ/ITPR2/PPP1R12A/PRKCI/ADCY7/MAPK14/ROCK2/PIK3R1/TLN1/ARHGEF12/STIM1/PIK3CA/PIK3R3/PIK3CB/AKT3/PLCG2/GNAI1/GNAI2/AKT2/MYLK3/ADCY6/ADCY2/ARHGAP35/PRKACB/GNA13/MAPK1/PRKCZ/PLCB1/PRKACA/ADCY9/VWF/ITPR1/SRC/MYLK4	-0.538318892932389
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	25/2885	89/9376	0.912897006990828	SLC38A1/SLC38A2/GABRE/ADCY7/GNG12/GABRA4/GLUL/TRAK2/GNAI1/GNAI2/GNB4/ADCY6/ADCY2/GNB1/PRKACB/GABARAPL1/ABAT/NSF/PRKACA/GNG10/GLS/ADCY9/PRKCA/SRC/GABRB1	-0.550418599930476
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	90/2885	308/9376	0.949650003376173	MT-ND6/CLTC/KIF5B/PSMD1/CREB3L2/MT-ND4L/POLR2J3/GNAQ/MT-ND1/MT-CO2/MT-ND4/COX6A1/MT-ND3/MT-ND2/MT-CYB/MT-CO3/MT-ND5/MT-CO1/RB1CC1/GPX8/RCOR1/AP2A2/POLR2A/EP300/REST/SLC1A3/MT-ATP6/SIN3A/POLR2B/AP2A1/CREBBP/NDUFS1/NDUFB9/AP2B1/MT-ATP8/TGM2/DCTN4/DCTN5/TFAM/HTT/DCTN1/CASP3/TAF4B/ATG14/CREB1/MTOR/HDAC2/SP1/ULK2/MAPK8/WIPI2/DNAH14/WIPI1/ATG2B/PPARG/ATG2A/PIK3C3/PLCB1/MAP2K7/TP53/UQCRC1/PSMA6/ERN1/KLC1/NRBF2/POLR2J2/PIK3R4/BECN1/ULK1/BDNF/NDUFA3/TBP/CREB5/DNAL1/KLC4/ATG13/APAF1/ACTR1B/TAF4/ITPR1/HIP1/PSMA8/KLC2/CREB3L4/AMBRA1/NRF1/SLC1A2/BBC3/MAP3K10/MAP3K5	-0.598993060051232
Organismal Systems	Digestive system	hsa04970	Salivary secretion	26/2885	93/9376	0.908577924377108	ATP2B1/ADRB1/KCNN4/ATP2B4/GNAQ/SLC9A1/ITPR2/ATP1A1/TRPV6/ADCY7/SLC4A2/VAMP2/CST3/ADCY6/ADCY2/SLC12A2/ATP1B3/PRKACB/PLCB1/BST1/ATP1A4/PRKACA/ADCY9/PRKCA/ITPR1/CHRM3	-0.590678439156462
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6/2885	23/9376	0.847803481274961	ATP1A1/GLUD1/ATP1B3/GLUD2/ATP1A4/GLS	-0.48718724763997
Organismal Systems	Endocrine system	hsa04924	Renin secretion	19/2885	69/9376	0.894903674679125	ADRB1/GNAQ/ITPR2/CTSB/PPP3CA/PDE3B/CREB1/GNAI1/EDN1/GNAI2/ADCY6/PRKACB/PLCB1/KCNJ2/CLCA2/PPP3CB/PRKACA/PPP3CC/ITPR1	-0.584130605982695
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	19/2885	69/9376	0.894903674679125	FOS/JUN/CREB3L2/FOSB/CAMK2G/ATF6B/PPP3CA/CREB1/HDAC2/ATF2/MAOA/PRKACB/SIRT1/PPP3CB/CREB5/PRKACA/PPP3CC/PRKCA/CREB3L4	-0.584130605982695
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/2885	20/9376	0.812478336221837	NPL/CYB5R1/GNE/CYB5R3/TGDS	-0.559659759177715
Human Diseases	Substance dependence	hsa05032	Morphine addiction	25/2885	91/9376	0.892833336507513	GABRE/PDE4B/ADCY7/PDE7A/GNG12/PDE10A/PDE3B/GABRA4/GNAI1/GNAI2/GNB4/ADCY6/ADCY2/GNB1/PRKACB/PDE8A/ARRB1/PDE4D/PRKACA/GRK5/GNG10/ADCY9/PRKCA/GRK4/GABRB1	-0.684844849911978
Cellular Processes	Cell motility	hsa04814	Motor proteins	55/2885	194/9376	0.921367185406207	MYH10/DYNC1H1/KIF5B/HOOK3/MYO7A/MYO1C/DYNLL2/DYNC1LI2/MYO6/KIFC3/MYO9A/DCTN4/DCTN5/MYO5B/MYO9B/DCTN1/KIF13B/KIF21A/KIF16B/KIF26B/MYH9/KIF3A/DNAH14/KIF1B/MYO1D/DYNC1LI1/KIF20B/CENPE/KIFAP3/KIF3B/KLC1/MYO5C/KIF14/DNAL1/MYO19/KIF1C/KLC4/DYNC2H1/KIF27/MYO1B/ACTR1B/TNNC2/KIF23/MYO5A/KIF20A/TUBE1/TUBD1/KIF11/KLC2/KIF15/KIF24/TUBG2/TNNT2/MYO18A/KIF18B	-0.737800226593114
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	32/2885	116/9376	0.896527819279269	SLC38A1/SLC38A2/GNAQ/ITPR2/HOMER1/SLC1A3/ADCY7/GNG12/SHANK2/PPP3CA/GLUL/GNAI1/GNAI2/GNB4/ADCY6/ADCY2/GNB1/PRKACB/MAPK1/PLCB1/PLD2/PPP3CB/PLD1/PRKACA/GNG10/GLS/ADCY9/PPP3CC/PRKCA/NCDN/ITPR1/SLC1A2	-0.747566524563111
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	66/2885	233/9376	0.920576312285687	FBN1/FBN2/ITGA6/ITGB4/DAG1/SYNE2/ITGAV/ITGB1/COL4A2/MYH10/DSC2/DSG2/ITGB5/DSP/DIAPH2/ITGB8/ANK3/COL4A1/FMNL2/FBLN1/PLEC/SPTBN1/SPTAN1/DMD/VCL/ATP1A1/DIAPH1/SSPN/DAAM1/LBR/SUN1/COL5A2/TLN1/INF2/BGN/SGCE/ITGB6/TMEM43/SNTB1/PKP2/JUP/MYH9/FN1/SNTB2/ITGA3/ATP1B3/SUN2/NID1/TTN/FBLN2/HSPG2/DIAPH3/SGCB/PDLIM5/ATP1A4/LAMA1/THBS1/NEB/NEBL/AMPD2/TNNC2/SYNE3/SDC3/ENO3/FMNL3/TNNT2	-0.818439141022904
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	8/2885	32/9376	0.812478336221837	GAA/B4GALT1/GLB1/G6PC3/GLA/GALT/GALM/GANC	-0.708374247448419
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	28/2885	103/9376	0.883471588901415	LAMB1/LAMC1/LAMA5/COL4A2/ACTN4/COL4A1/GNAQ/VCL/PIK3R1/PIK3CA/RAB5B/PIK3R3/PTK2/PIK3CB/LAMB4/CASP3/LAMB2/NFKB1/GNA11/FN1/ACTN1/RAB7B/PRKACB/PLCB1/LAMA1/PRKACA/PRKCA/IL1R1	-0.792762410625798
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	13/2885	51/9376	0.828409283990893	PLPP3/PLD3/CHPT1/PAFAH1B2/CEPT1/PAFAH1B1/PLA2G12A/PLD2/PAFAH2/PLD1/AGPS/GDPD3/PLA2G6	-0.819138232415466
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	50/2885	181/9376	0.897766117372196	EEA1/IL10RB/CTSD/ATP6AP1/LAMP2/CAMK2G/EP300/LAMP1/BCL2/MAPK14/PLA2R1/ARHGEF12/CREBBP/KSR1/ATP6V0A1/RAB5B/PPP3CA/ATP6V1H/IFNGR1/CASP3/ATP6V0B/AKT3/CD74/NFKB1/CREB1/AKT2/MAPK8/NFYC/MAPK1/PIK3C3/TCIRG1/MALT1/JAK1/RAF1/IRAK4/ATP6V0A2/CEBPG/ATP6V0A4/PPP3CB/SPHK2/MYD88/RFX5/PPP3CC/APAF1/RFXAP/TRAF6/JAK2/SRC/NFYA/TIRAP	-0.925893462631951
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	28/2885	105/9376	0.866643558636626	ITGA6/ITGB4/DAG1/ITGAV/ITGB1/ADRB1/ITGB5/ITGB8/ATP2A2/DMD/SSPN/ADCY7/SGCE/ITGB6/SNTB1/SNTB2/ADCY6/ITGA3/ADCY2/PRKACB/TTN/SGCB/LAMA1/PRKACA/ADCY9/SLC8A1/TNNT2/CACNA2D3	-0.916111002680349
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	12/2885	48/9376	0.812478336221837	ATP1A1/PIK3R1/PIK3CA/PIK3R3/PIK3CB/G6PC3/AKT3/AKT2/ATP1B3/PLCB1/SLC37A4/ATP1A4	-0.868321471025461
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	15/2885	59/9376	0.826249155479834	CANT1/ENTPD4/NME3/ENTPD6/RRM2B/NT5C3A/TK2/NT5C2/ENTPD5/DPYD/AK9/CAD/UCK1/DHODH/CDADC1	-0.892519317415086
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	18/2885	70/9376	0.835692002971032	DAG1/CD55/EIF4G1/DMD/SSPN/EIF4G2/SGCE/EIF4G3/CASP3/SNTB1/CCND1/SNTB2/HLA-E/RAC3/ABL2/ABL1/SGCB/LAMA1	-0.919875262296111
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	26/2885	99/9376	0.853512595626981	ITGA6/ITGB4/DAG1/ITGAV/ITGB1/ITGB5/ITGB8/ATP2A2/DMD/SSPN/PRKAB2/SGCE/ITGB6/SNTB1/EDN1/SNTB2/ITGA3/PRKAA1/TTN/SGCB/LAMA1/PRKAA2/SLC8A1/PRKAB1/TNNT2/CACNA2D3	-0.976825177933254
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	9/2885	38/9376	0.769716318525951	HEXA/HEXB/UXS1/GFPT1/NAGK/GNE/PGM3/GALT/FPGT	-0.948267289153021
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	25/2885	97/9376	0.837606532187461	FOS/GNAQ/RPS6KA5/CAMK2G/ADCY7/GNG12/CREB1/GNAI1/GNAI2/GNB4/ADCY6/ADCY2/GNB1/PRKACB/MAPK1/PLCB1/PER3/PRKACA/GNG10/ADCY9/PRKCA/RASD1/PER2/ITPR1/PER1	-1.07178229398608
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	21/2885	83/9376	0.822267231838968	ADAR/MAVS/G3BP1/NFKBIA/DNASE2/CASP3/NFKB1/POLR3A/POLR3E/POLR3B/IKBKB/ZCCHC3/IRF3/IFI16/RIPK1/TBK1/CHUK/PYCARD/IKBKG/IKBKE/ZDHHC1	-1.08425472898842
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	41/2885	155/9376	0.859654497679879	ITGAV/ITGB1/TFRC/COLEC12/CANX/EEA1/ITGB5/DYNC1H1/OLR1/CALR/CTSL/ATP6AP1/ATP6V1B1/LAMP2/SEC61A1/LAMP1/PLA2R1/DYNC1LI2/ATP6V0A1/RAB5B/ATP6V1H/PIKFYVE/HGS/ATP6V0B/ATP6V1C2/DYNC1LI1/ATP6V1A/STX7/M6PR/HLA-E/RAB7B/PIK3C3/TCIRG1/STX12/SEC61A2/ATP6V1E2/ATP6V0A2/ATP6V0A4/ATP6V1B2/THBS1/DYNC2H1	-1.17456777012327
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/2885	28/9376	0.69641000247586	GGH/MOCS2/CBR1/MOCS1/FPGS/PCBD2	-1.07253102742018
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	89/2885	323/9376	0.895486958807969	EGFR/MET/CDK6/DICER1/ROCK1/SOX4/DNMT3A/RPS6KA5/ERBB3/TIMP3/FOXP1/ABCB1/ST14/MDM4/KRAS/EP300/BCL2/BMPR2/MDM2/TP63/NOTCH3/EFNA5/RDX/ATM/PIK3R1/MCL1/EFNA1/CREBBP/FZD3/PIK3CA/IRS2/PIK3R3/PIK3CB/APC/SOCS1/SOS1/CASP3/ERBB2/NFKB1/PLCG2/SHC1/MTOR/HDAC2/CDKN1A/CCND1/DNMT1/BMI1/PTEN/CRK/SOS2/E2F3/NOTCH2/IKBKB/CDKN1B/BRCA1/MAPK1/SPRY2/HRAS/TP53/PDGFB/BCL2L11/STAT3/CRKL/RAF1/ABL1/PLAU/EZH2/BCL2L2/RPTOR/PDGFA/ABCC1/SIRT1/MYC/PAK4/THBS1/CCND2/WNT3/GLS/EFNA4/HDAC4/PRKCA/IRS1/KIF23/DNMT3B/MAPK7/PRKCE/HDAC5/CDC25A/PLCG1	-1.2743192060675
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/2885	16/9376	0.609358752166378	GOT2/MAOA/GOT1	-1.04256444013053
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	19/2885	78/9376	0.791645558369995	ITGB1/FOS/JUN/MAPK14/CASP3/NFKB1/GNAI1/GNAI2/SERPING1/MAPK8/IRF3/MAPK1/IRAK4/MYD88/PYCARD/TRAF6/NOD1/C1S/TIRAP	-1.2318505899563
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	12/2885	52/9376	0.749980002666311	IGF1R/ADCY7/LDLR/HSD17B1/INSR/ADCY6/ADCY2/PRKACB/PRKACA/HSD17B7/ADCY9/HSD17B2	-1.20525246389371
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	40/2885	154/9376	0.844133336334376	GUSB/AK3/GCLM/GGH/PANK3/MAT2A/MAT2B/BCAT1/DHRS3/GGCX/MOCS2/NME3/COQ4/MOCS1/ALAD/TPK1/RDH11/COASY/COX15/GCLC/VKORC1L1/MTHFD2L/PNPO/NADSYN1/COQ6/CPOX/COX10/COQ7/FECH/LIAS/NADK2/EARS2/AK9/NADK/NMNAT1/PANK1/CAD/OXSM/FPGS/DHODH	-1.30018090423634
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/2885	37/9376	0.702683966462129	UXS1/GFPT1/NAGK/GNE/PGM3/GALT/TGDS/FPGT	-1.20801338676386
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	18/2885	75/9376	0.779979202772964	MTR/IDH1/ALDH18A1/PC/MAT2A/MAT2B/BCAT1/GLUL/GOT2/ACO1/ACO2/RPIA/CS/ASS1/GOT1/SDSL/ENO3/CPS1	-1.27535851430283
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/2885	12/9376	0.541652224147891	CD46/NPC1	-1.05915078188384
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	25/2885	102/9376	0.796547388452782	ATP2B1/ATP2B4/GNAQ/SLC9A1/ITPR2/ATP2A2/ATP1A1/ADCY7/SLC4A2/ADCY6/ADCY2/SLC12A2/ATP1B3/PLCB1/PLA2G12A/CLCA2/RAB27B/BST1/ATP1A4/ADCY9/PRKCA/ITPR1/CCK/CHRM3/TPCN2	-1.37731269778924
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	11/2885	50/9376	0.714980935875217	ALDH18A1/OAT/GOT2/ALDH4A1/AOC1/MAOA/AMD1/GOT1/CKMT1B/CKMT1A/L3HYPDH	-1.34714377525987
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	67/2885	254/9376	0.857260606722253	ATP2B1/EGFR/MET/ADRB1/ASPH/ATP2B4/PHKB/GNAQ/ERBB3/ITPR2/MCOLN3/ATP2A2/CAMK2G/FGFR2/ADCY7/NFATC3/P2RX4/PDGFD/STIM2/STIM1/PPP3CA/ERBB2/PLCG2/EDNRB/NFATC2/PHKA2/GNA11/TPCN1/MYLK3/ADCY2/PRKACB/PLCB1/PLCE1/PDGFB/ORAI3/ERBB4/TFEB/PDGFA/P2RX7/PDGFC/FGFR1/MCU/MCOLN1/PPP3CB/SPHK2/PHKG2/PRKACA/ITPKC/CASQ1/ADCY9/PPP3CC/PRKCA/CHRM5/ADORA2B/TNNC2/ITPR1/SLC8A1/PHKA1/MCOLN2/CHRM3/TPCN2/MST1/PHKG1/TACR1/FGF2/MYLK4/PLCG1	-1.53751164285372
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	53/2885	205/9376	0.840221498922095	MT-ND6/SLC2A1/CTSD/MT-ND4L/MT-ND1/MT-CO2/MT-ND4/COX6A1/MT-ND3/MT-ND2/MT-CYB/MT-CO3/MT-ND5/MT-CO1/ATP2A2/CAMK2G/CPT2/TGFBR1/MT-ATP6/MAPK14/PARP1/PIK3R1/GSK3B/GFPT1/TGFBR2/PIK3CA/SMAD2/NDUFS1/INSR/PIK3R3/NDUFB9/MT-ATP8/PIK3CB/GSR/AKT3/NFKB1/MTOR/SP1/AKT2/PTEN/MAPK8/PDK2/PPARA/PDK4/PRKCZ/PLCB1/UQCRC1/TBC1D4/NDUFA3/SMAD3/PRKCA/IRS1/AGER	-1.54201880077665
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	19/2885	82/9376	0.753028701864142	HSPA5/CANX/LGMN/PDIA3/CALR/CTSL/TAPBP/CTSB/HSPA1B/CD74/HSPA8/CREB1/HSPA1A/HLA-E/NFYC/TAPBPL/RFX5/RFXAP/NFYA	-1.49745858150577
Organismal Systems	Digestive system	hsa04976	Bile secretion	21/2885	90/9376	0.758313113807048	SLC2A1/SLC9A1/ABCB1/ATP1A1/NCEH1/HMGCR/ADCY7/SLC4A2/LDLR/RXRA/ADCY6/ADCY2/ATP1B3/PRKACB/EPHX1/ABCG2/ATP1A4/PRKACA/ADCY9/ABCB4/ABCC2	-1.53589930503502
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	58/2885	226/9376	0.834048557537461	ATP2B1/FOS/ADRB1/JUN/CREB3L2/ROCK1/ATP2B4/GLI3/SLC9A1/ATP2A2/PDE4B/PPP1R12A/ATP1A1/CAMK2G/EP300/ADCY7/ROCK2/VAV3/PIK3R1/CREBBP/PIK3CA/PDE10A/PIK3R3/PIK3CB/PDE3B/NFKBIA/AKT3/ACOX1/NFKB1/CREB1/GNAI1/EDN1/GNAI2/AKT2/BRAF/MAPK8/TIAM1/ADCY6/PPARA/ADCY2/ATP1B3/PRKACB/MAPK1/PLCE1/RAC3/RAF1/PTCH1/PLD2/PDE4D/BDNF/CREB5/ATP1A4/PLD1/PRKACA/ADCY9/CNGB1/CREB3L4/RAPGEF3	-1.6835555337789
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	24/2885	103/9376	0.757261361915499	COL14A1/COL4A2/MME/DPP4/KCNN4/SLC38A2/SLC1A5/COL4A1/COL21A1/SLC3A2/ATP1A1/COL5A2/KCNK5/PRCP/ATP1B3/COL8A1/SLC7A8/SLC36A4/ATP1A4/ACE2/SLC8A1/COL7A1/SLC16A10/COL2A1	-1.6513918456941
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	32/2885	133/9376	0.781934037867633	KRAS/VAV3/PIK3R1/PIK3CA/PPP3CA/PIK3R3/PIK3CB/PTPN11/SOS1/IFNGR1/CASP3/PLCG2/SHC1/NFATC2/IFNAR1/BRAF/SOS2/HLA-E/MAPK1/HRAS/RAC3/IFNAR2/RAF1/TNFRSF10B/PPP3CB/ARAF/PPP3CC/PRKCA/PTPN6/LAT/TNFSF10/PLCG1	-1.68853461568005
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	36/2885	149/9376	0.785213962523118	MT-ND6/GABRE/MT-ND4L/GNAQ/ITPR2/MT-ND1/MT-ND4/MT-ND3/MT-ND2/MT-ND5/ADCY7/MAPK14/GNG12/NDUFS1/NDUFB9/GABRA4/GNAI1/GNAI2/GNB4/MAPK8/ADCY6/NAPEPLD/ADCY2/GNB1/PRKACB/MAPK1/PLCB1/FAAH/NDUFA3/PRKACA/GNG10/ADCY9/PRKCA/ITPR1/DAGLB/GABRB1	-1.76186108084665
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	8/2885	42/9376	0.619031113311876	HADHA/CAT/DHTKD1/AOC1/MAOA/EHHADH/DLST/GCDH	-1.6496165233903
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	17/2885	78/9376	0.708314446962627	ITGB1/FOS/JUN/MAPK14/TAB2/NFKBIA/IFNGR1/NFKB1/MAP3K7/MAPK1/JAK1/IRAK4/TAB1/MYD88/TRAF6/PTPN6/JAK2	-1.72452776998574
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	41/2885	168/9376	0.793133613930841	TRPM7/CAMK2G/BCL2/CFLAR/SMPD1/PARP1/TLR3/XIAP/BIRC2/DNM1L/GLUL/IFNGR1/GLUD1/EIF2AK2/IFNAR1/MAPK8/CHMP4C/CYLD/CAPN1/CHMP1B/AIFM1/VPS4B/GLUD2/JAK1/IFNAR2/TRAF5/RIPK1/STAT3/STAT5B/STAT2/PYGB/TNFRSF10B/TYK2/CHMP1A/CAPN2/CHMP7/PYCARD/SPATA2/USP21/JAK2/TNFSF10	-1.80370145401064
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	9/2885	47/9376	0.622323831999705	ACSS1/PC/ACACA/HAGH/ACSS2/ME2/ME1/DLAT/ACYP2	-1.73042868532295
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	8/2885	43/9376	0.604635040909274	PLPP3/ABCA1/AGPAT1/GOT2/DGAT1/PLA2G12A/SLC27A4/SLC27A1	-1.73230561360101
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	68/2885	268/9376	0.824604878553506	SLC39A10/HSPA5/MT-ND6/KIF5B/PSMD1/MT-ND4L/DUSP1/ITPR2/MT-ND1/MT-CO2/MT-ND4/COX6A1/MT-ND3/MT-ND2/MT-CYB/MT-CO3/MT-ND5/MT-CO1/ATF6/SLC39A7/CAMK2G/MT-ATP6/SLC11A2/NFE2L2/UBE2G2/XBP1/DDIT3/NDUFS1/NDUFB9/UBA1/MT-ATP8/GPR37/CASP3/SLC39A1/GNAI1/GNAI2/MAPK8/MAOA/PRKACB/SLC39A9/TP53/UQCRC1/PSMA6/BCL2L1/EIF2AK3/ERN1/KLC1/MFN2/PINK1/SLC39A3/SLC39A8/SLC39A13/NDUFA3/DAXX/MFN1/MCU/PRKACA/KLC4/KEAP1/APAF1/UBA7/ITPR1/SLC39A6/SLC39A11/PSMA8/KLC2/PLCG1/MAP3K5	-1.94212034531916
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	26/2885	115/9376	0.734763017104966	APP/SLC6A4/DUSP1/GNAQ/ITPR2/KRAS/GNG12/CASP3/GNAI1/GNAI2/GNB4/BRAF/MAOA/GNB1/PRKACB/MAPK1/PLCB1/HRAS/RAF1/ARAF/PRKACA/GNG10/PRKCA/ITPR1/GABRB1/RAPGEF3	-1.90790523466089
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/2885	31/9376	0.524179571756024	PGD/RPIA/H6PD/SHPK/GLYCTK	-1.76903742178197
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	32/2885	138/9376	0.753603094466632	MT-ND6/MT-ND4L/MT-ND1/MT-CO2/MT-ND4/COX6A1/MT-ND3/MT-ND2/MT-CYB/MT-CO3/MT-ND5/MT-CO1/ATP6AP1/ATP6V1B1/MT-ATP6/ATP6V0A1/NDUFS1/NDUFB9/MT-ATP8/ATP6V1H/ATP6V0B/ATP6V1C2/ATP6V1A/COX15/TCIRG1/UQCRC1/ATP6V1E2/ATP6V0A2/ATP6V0A4/COX10/ATP6V1B2/NDUFA3	-1.94396551239511
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/2885	22/9376	0.443170001575547	AOC1/MAOA/CARNMT1	-1.74316310090667
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	29/2885	128/9376	0.73630849220104	PDE4B/ADCY7/AK3/PDE7A/CANT1/PDE10A/ENTPD4/PDE3B/NME3/ENTPD6/RRM2B/PPAT/ADCY6/ADCY2/NT5C2/GART/LACC1/PDE8A/FHIT/ENTPD5/NUDT9/PDE4D/PFAS/ENPP4/PAPSS1/AK9/ADCY9/AMPD2/ADPRM	-2.00253428459918
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/2885	41/9376	0.554863254005157	GLDC/MAOA/AMT/SDSL/CHDH/DMGDH/GLYCTK	-1.90428065832226
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/2885	37/9376	0.527012974846597	GNAQ/APOL1/PLCB1/MYD88/PRKCA/F2RL1	-1.92177546347546
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	36/2885	160/9376	0.731230502599653	CDH1/ITGA6/ITGAV/ITGB1/GLG1/CLDN4/PTPRF/CADM1/ITGB8/NRCAM/JAM3/PTPRM/F11R/NLGN4X/OCLN/NRXN3/CDH3/CNTNAP2/CD276/ALCAM/HLA-E/LRRC4/NLGN1/CD99L2/CD274/CLDN19/CLDN12/CLDN3/CLDN1/NEO1/CLDN23/CDH5/SELP/SDC3/PVR/CD58	-2.28597501745923
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/2885	35/9376	0.464273334983907	ENOSF1/PFKFB4/TKFC/FPGT/PFKFB2	-2.11681713237629
NA	NA	hsa04382	Cornified envelope formation	51/2885	217/9376	0.763804518844492	ITGA6/ITGB4/LAMA5/COL4A2/DST/CLDN4/DSG2/DSP/COL4A1/PLEC/PRSS8/ST14/TJP1/FURIN/SPTLC3/KRT80/OCLN/KDSR/ELOVL4/PKP2/PPP2R2A/JUP/ELOVL1/PCSK6/PPP2R5E/EPHX2/GBA2/PPP2R5C/PPP2R3A/PPP2R2B/CAPN1/SPTLC2/SPTLC1/PPP2R3B/UGCG/PPP2R2D/PPP2R1A/CLDN19/SLC27A4/CLDN12/PPP2R5A/CLDN3/CLDN1/CLDN23/PPP2R5D/PPP2R1B/TMEM79/COL7A1/ABCA12/KAZN/SLC27A1	-2.34682207302011
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	17/2885	87/9376	0.635040538656149	ASPH/SLC9A1/MT-CO2/COX6A1/MT-CYB/MT-CO3/MT-CO1/ATP2A2/ATP1A1/ATP1B3/UQCRC1/SLC9A7/ATP1A4/SLC9A6/SLC8A1/TNNT2/CACNA2D3	-2.27993525498795
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/2885	36/9376	0.451376853456576	AGL/GAA/G6PC3/PYGB/GANC	-2.19864281701138
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/2885	26/9376	0.374990001333156	ACOX1/PLA2G12A/PLA2G6	-2.12750493425457
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	3/2885	26/9376	0.374990001333156	HES1/MAFA/RFX6	-2.12750493425457
NA	NA	hsa04081	Hormone signaling	51/2885	219/9376	0.756829135110752	ITGAV/ADRB1/IGF1R/PRLR/GNA12/SLC40A1/GNAQ/SLC16A2/SMAD5/ADCY7/GNG12/PIK3R1/BMPR1A/GHR/PIK3CA/IRS2/INSR/SMAD4/PIK3R3/PIK3CB/APPL1/GNAI1/GNAI2/GNB4/GNA11/ADCY6/ADIPOR1/ADCY2/THRB/GNB1/PRKACB/GNA13/ADIPOR2/PLCB1/ACVR1/STAT3/STAT5B/SMAD1/RAMP1/PRKACA/GNG10/ADCY9/STK11/IRS1/ESR2/CCK/JAK2/SRC/SLC16A10/RAPGEF3/ADRA2B	-2.42750275886256
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/2885	46/9376	0.494552030743727	GUSB/ALAD/COX15/CPOX/COX10/FECH/EARS2	-2.29095887037024
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/2885	15/9376	0.216660889659157	TPK1	-2.02412374543025
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/2885	38/9376	0.427620176958862	DCLRE1C/BLNK/RFX5/RFXAP/IKBKG	-2.35695842487333
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/2885	29/9376	0.336197932229726	GNB1/SLC24A1/CNGB1	-2.3867351048854
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	10/2885	63/9376	0.51585926109323	CBR1/PTGES/EPHX2/PTGES2/PLA2G12A/PTGR2/GGT1/CBR3/CYP2U1/PLA2G6	-2.57039486131203
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	17/2885	95/9376	0.581563440664052	FOS/JUN/CTSL/ATP6AP1/ATP6V1B1/ATP6V0A1/ATP6V1H/ATP6V0B/ATP6V1C2/ATP6V1A/ANGPT1/TCIRG1/ATP6V1E2/ATP6V0A2/ACP5/ATP6V0A4/ATP6V1B2	-2.73273035582214
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	15/2885	88/9376	0.553962501969434	F5/CD46/CD55/TFPI/SERPING1/CLU/CD59/F3/SERPINE2/PLAU/THBD/CFD/VWF/SERPINB2/C1S	-2.80255630213242
Genetic Information Processing	Transcription	hsa03040	Spliceosome	54/2885	243/9376	0.722202965530522	SF1/RBM25/FUS/TRA2B/PRPF38B/SF3B1/DDX5/THOC2/TCERG1/PRPF8/SRSF6/SRSF5/PRPF40A/TRA2A/SNRNP200/DDX46/DDX39B/AQR/DDX42/U2SURP/DHX15/HSPA1B/SRSF8/HNRNPU/HSPA8/SRSF10/U2AF1/CASC3/SRSF7/SRSF2/PRPF6/HSPA1A/CDC40/SRSF4/ACIN1/CHERP/RBMXL1/NCBP1/SF3B3/DHX8/EFTUD2/LSM8/CWC25/PRPF40B/CRNKL1/SF3A1/USP39/DDX23/DHX38/THOC1/DHX16/SNIP1/PRPF3/GPKOW	-2.92500596185673
Human Diseases	Substance dependence	hsa05034	Alcoholism	40/2885	191/9376	0.680610124583738	CREB3L2/FOSB/KRAS/SLC29A3/GNG12/ATF6B/SLC29A1/SOS1/CREB1/SHC1/GNAI1/HDAC2/GNAI2/GNB4/BRAF/SOS2/ATF2/MAOA/GNB1/PRKACB/MAPK1/HRAS/CAMKK2/SLC29A2/HDAC11/RAF1/HDAC7/HDAC6/BDNF/CREB5/ARAF/PRKACA/HDAC8/GNG10/HDAC4/ADORA2B/PKIA/CREB3L4/HDAC10/HDAC5	-2.97304163148821
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	14/2885	85/9376	0.535279845040269	AK3/CANT1/ENTPD4/NME3/ENTPD6/RRM2B/NT5C3A/TK2/NT5C2/LACC1/ENTPD5/AK9/AMPD2/UCK1	-2.8692770424332
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	13/2885	82/9376	0.51523016443336	GUSB/MGST3/NME3/RRM2B/MGST2/TK2/CES2/DPYD/GSTM3/GSTM2/UCK1/GSTO2/CDADC1	-2.93930005552741
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/2885	50/9376	0.389989601386482	LRP1/MET/CD81/THBS1/MYD88/SELP	-2.88321665029471
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	10/2885	70/9376	0.464273334983907	MGST3/CBR1/MGST2/GSTK1/EPHX1/GSTM3/GSTM2/SULT1A3/GSTO2/HSD11B1L	-2.99925575998482
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	9/2885	66/9376	0.443170001575547	JUN/GATA3/SMAD2/IFNGR1/NFKB1/IL4R/STAT3/SMAD3/RORA	-3.02637327997828
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/2885	30/9376	0.216660889659157	PLA2G12A/PLA2G6	-2.8648394721637
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/2885	37/9376	0.263506487423299	GOT2/MAOA/GOT1	-2.99241857854285
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	59/2885	275/9376	0.697254135812195	LAMC1/HSPA5/MT-ND6/KIF5B/PSMD1/CREB3L2/MT-ND4L/ITPR2/MT-ND1/MT-CO2/MT-ND4/COX6A1/MT-ND3/MT-ND2/MT-CYB/MT-CO3/MT-ND5/MT-CO1/EGR1/MT-ATP6/MAPK14/PIK3R1/GSK3B/ATF6B/PIK3CA/DDIT3/NDUFS1/PPP3CA/PIK3R3/NDUFB9/MT-ATP8/PIK3CB/HSPA1B/CASP3/HSPA8/CREB1/HSPA1A/MAPK8/ATF2/PRKACB/CSNK2A1/PRNP/MAPK1/UQCRC1/PSMA6/EIF2AK3/KLC1/NDUFA3/MCU/PPP3CB/CREB5/PRKACA/KLC4/PPP3CC/APAF1/ITPR1/PSMA8/KLC2/CREB3L4	-3.39705635085824
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	11/2885	79/9376	0.452519579667859	MGST3/CBR1/MGST2/GSTK1/EPHX1/CYP2S1/GSTM3/GSTM2/CBR3/GSTO2/HSD11B1L	-3.25771782810211
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8/2885	66/9376	0.393928890289376	STS/HSD17B1/HSD17B12/HSD17B11/SRD5A3/HSD17B7/HSD17B2/HSD11B1L	-3.29399891777538
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/2885	67/9376	0.388049354613415	ACSS1/G6PC3/MINPP1/ADPGK/ACSS2/GALM/DLAT/ENO3	-3.35123610047796
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	48/2885	238/9376	0.655444708212575	EGFR/IL6ST/NRP1/FOS/JUN/RPS21/ADAR/MAPK14/TLR3/PIK3R1/ADAM17/PIK3CA/MAVS/PIK3R3/PIK3CB/TAB2/NFKBIA/NFKB1/PLCG2/EIF2AK2/IFNAR1/MAPK8/IKBKB/IRF3/MAP3K7/MAPK1/JAK1/IFNAR2/STAT3/IFIH1/IRAK4/HBEGF/STAT2/TBK1/CHUK/CFD/TYK2/ACE2/MYD88/TRAF3/PRKCA/VWF/SELP/TRAF6/IKBKG/IKBKE/C1S/PLCG1	-3.58942239715439
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/2885	46/9376	0.282601160424987	PSMD1/PSME4/PSMA6/PSMA8	-3.25163287832775
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	8/2885	68/9376	0.382342746457335	RDH10/DHRS3/ALDH1A3/RDH11/RETSAT/DGAT1/DHRS4L2/CYP2S1	-3.40781929385418
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/2885	41/9376	0.237798537430782	GABRE/GABRA4/GABRB1	-3.26067330090138
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8/2885	73/9376	0.356154887110942	MGST3/MGST2/MAOA/GSTK1/GSTM3/GSTM2/GSTO2/FMO4	-3.68157850328843
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/2885	31/9376	0.104835914351205	GUSB	-3.32810167901405
Human Diseases	Immune disease	hsa05310	Asthma	1/2885	32/9376	0.10155979202773	PRG2	-3.39391136670296
Organismal Systems	Sensory system	hsa04742	Taste transduction	10/2885	86/9376	0.377896900568296	KCNK5/GABRA4/ADCY6/PRKACB/PLCB1/SCN2A/PRKACA/TAS2R14/TAS2R4/CHRM3	-3.86372738502314
NA	NA	hsa04082	Neuroactive ligand signaling	35/2885	199/9376	0.571592799352046	ADRB1/SLC6A4/GABRE/GNAQ/SLC1A3/ADCY7/GNG12/P2RX4/P2RY6/GABRA4/GNAI1/GNAI2/GNB4/GLRB/GNA11/ADCY6/ADCY2/GNB1/PRKACB/PLCB1/PRKACA/GNG10/ADCY9/PRKCA/OGFR/CHRM5/ADORA2B/TAC3/ACHE/CHRM3/P2RY2/GABRB1/SLC1A2/TACR1/ADRA2B	-4.07226167009249
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	12/2885	100/9376	0.389989601386482	CSF3R/ITGA6/TFRC/MME/CD55/CSF2RA/IL4R/CD59/ITGA3/IL11RA/ANPEP/IL1R1	-4.08845865937168
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/2885	44/9376	0.147723333858516	HLA-E/ICA1	-3.77765518383493
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/2885	36/9376	0.0902753706913152	GUSB	-3.64578041282035
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	29/2885	183/9376	0.515013590173405	LSG1/XPO1/XRN1/UTP14C/WDR43/XRN2/REXO1/MPHOSPH10/NXF1/TCOF1/MDN1/HEATR1/WDR36/BMS1/NOP56/CSNK2A1/WDR75/GTPBP4/RBM28/NVL/UTP6/DROSHA/GNL3L/NAT10/RCL1/TBL3/NMD3/WDR3/NOL6	-4.41701858162828
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/2885	39/9376	0.0833311114073679	HLA-E	-3.82422871620335
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	31/2885	195/9376	0.516652890725681	MAPK14/CLCN3/PIK3R1/PIK3CA/CLCN5/PIK3R3/PIK3CB/AKT3/NFKB1/PLCG2/MTOR/HDAC2/AKT2/MAP3K7/MAPK1/PLCB1/HDAC11/RAF1/HDAC7/HDAC6/ATG7/HDAC8/HDAC4/PRKCA/VWF/SELP/SRC/HDAC10/HDAC5/AGER/PLCG1	-4.54709659315562
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/2885	50/9376	0.129996533795494	LTBR/IL15RA	-4.11207495032258
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/2885	45/9376	0.0722202965530522	HLA-E	-4.15900815571133
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	8/2885	100/9376	0.259993067590988	IL6ST/IL10RB/LTBR/TNFRSF10B/TNFRSF10C/TNFSF10/XCR1/CXCR2	-4.95973143683989
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/2885	54/9376	0.0601835804608768	HLA-E	-4.6173000894078
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/2885	99/9376	0.131309630096459	CFD/DEFB1/SELP/C1S	-5.79270708482988
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	40/2885	298/9376	0.43622997917951	CSF3R/IL6ST/BMP7/IL10RB/PRLR/LIFR/TGFBR1/BMPR2/CSF2RA/BMPR1A/TGFBR2/GHR/ACVR2B/ACVR2A/IFNGR1/TNFRSF21/BMP4/LTBR/IFNAR1/IL4R/IFNAR2/ACVR1/TNFSF15/TNFRSF10B/IL13RA1/IL17RA/IL11RA/IL17RC/IL36RN/EDA2R/ACVR1C/IL17RE/TNFRSF10C/TNFRSF25/IL1R1/GDF11/TNFSF10/XCR1/IL15RA/CXCR2	-6.59352660948941
Genetic Information Processing	Translation	hsa03010	Ribosome	4/2885	222/9376	0.0585569972051775	RPS21/MRPS5/MRPL1/MRPS27	-9.46384911276249
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	34/2885	370/9376	0.298640685746405	ADRB1/PRLR/GABRE/NR3C1/S1PR2/P2RX4/GHR/S1PR3/P2RY6/GABRA4/PGRMC2/ADM/APELA/EDN1/EDNRB/GLRB/THRB/CHRNB1/P2RX7/CALCRL/LPAR1/TRPV1/F2RL1/OGFR/CHRM5/ADORA2B/CCK/TAC3/S1PR1/CHRM3/P2RY2/GABRB1/TACR1/ADRA2B	-9.17652394156798
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	9/2885	449/9376	0.0651430291848244	CAMK2G/RGS2/GNB1/PRKACB/ARRB1/ANO2/PRKACA/CNGB1/SLC8A1	-13.5337551865
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/2885	143/9376	0.0681800002423919	ACTN4/ACTN1/C1S	-7.48568194816581